Anatomical and pharmacological characterization of excitatory amino acid receptors

International Nuclear Information System (INIS)

Monaghan, D.T.

1985-01-01

The majority of the excitatory neurotransmission in the vertebrate Central Nervous System is thought to be mediated by acidic amino acid neurotransmitters. However, relatively little is known about the excitatory amino acid receptors and their distribution within the CNS. By analyzing radioligand binding to purified synaptic plasma membranes and to thin tissue sections processed for autoradiography, multiple distinct binding sites were found. These binding sites exhibited the pharmacological properties indicative of the excitatory amino acid receptors, which had been identified by electrophysiological techniques. Specifically, L-[ 3 H]-glutamate and D-[ 3 H]-amino-5-phosphonopentanoate appear to label N-methyl-D-aspartate receptors, L-[ 3 H]-glutamate and [ 3 H]-kainic acid appear to label kainic acid receptors, and L-[ 3 H]-glutamate and [ 3 H]-amino-3-hydroxy-5-methyl-4-isoxazolepropionate appear to label quisqualate receptors. Together, these results confirm the three receptor scheme proposed for excitatory amino acid neurotransmission. These results also show that these transmitter-receptor systems are differentially distributed in the brain, and that the total distribution is consistent with that found by other markers for excitatory amino acid-using neurons

IMPROVED DISTANCES TO TYPE Ia SUPERNOVAE WITH TWO SPECTROSCOPIC SUBCLASSES

International Nuclear Information System (INIS)

Wang, X.; Filippenko, A. V.; Ganeshalingam, M.; Li, W.; Silverman, J. M.; Chornock, R.; Foley, R. J.; Macomber, B.; Serduke, F. J. D.; Steele, T. N.; Wong, D. S.; Wang, L.; Gates, E. L.

2009-01-01

We study the observables of 158 relatively normal Type Ia supernovae (SNe Ia) by dividing them into two groups in terms of the expansion velocity inferred from the absorption minimum of the Si II λ6355 line in their spectra near B-band maximum brightness. One group ('Normal') consists of normal SNe Ia populating a narrow strip in the Si II velocity distribution, with an average expansion velocity (v) = 10, 600 ± 400 km s -1 near B maximum; the other group ('HV') consists of objects with higher velocities, v ∼> 11, 800 km s -1 . Compared with the Normal group, the HV one shows a narrower distribution in both the peak luminosity and the luminosity decline rate Δm 15 . In particular, their B-V colors at maximum brightness are found to be on average redder by ∼ 0.1 mag, suggesting that they either are associated with dusty environments or have intrinsically red B-V colors. The HV SNe Ia are also found to prefer a lower extinction ratio R V ∼ 1.6 (versus ∼ 2.4 for the Normal ones). Applying such an absorption-correction dichotomy to SNe Ia of these two groups remarkably reduces the dispersion in their peak luminosity from 0.178 mag to only 0.125 mag.

Irregular persistent activity induced by synaptic excitatory feedback

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Francesca Barbieri

2007-11-01

Full Text Available Neurophysiological experiments on monkeys have reported highly irregular persistent activity during the performance of an oculomotor delayed-response task. These experiments show that during the delay period the coefficient of variation (CV of interspike intervals (ISI of prefrontal neurons is above 1, on average, and larger than during the fixation period. In the present paper, we show that this feature can be reproduced in a network in which persistent activity is induced by excitatory feedback, provided that (i the post-spike reset is close enough to threshold , (ii synaptic efficacies are a non-linear function of the pre-synaptic firing rate. Non-linearity between presynaptic rate and effective synaptic strength is implemented by a standard short-term depression mechanism (STD. First, we consider the simplest possible network with excitatory feedback: a fully connected homogeneous network of excitatory leaky integrate-and-fire neurons, using both numerical simulations and analytical techniques. The results are then confirmed in a network with selective excitatory neurons and inhibition. In both the cases there is a large range of values of the synaptic efficacies for which the statistics of firing of single cells is similar to experimental data.

THE ULTRAVIOLET BRIGHTEST TYPE Ia SUPERNOVA 2011de

International Nuclear Information System (INIS)

Brown, Peter J.

2014-01-01

We present and discuss the ultraviolet (UV)/optical photometric light curves and absolute magnitudes of the Type Ia supernova (SN Ia) 2011de from the Swift Ultraviolet/Optical Telescope. We find it to be the UV brightest SN Ia yet observed—more than a factor of 10 brighter than normal SNe Ia in the mid-ultraviolet. We find that the UV/optical brightness and broad light curve evolution can be modeled with additional flux from the shock of the ejecta hitting a relatively large red giant companion separated by 6 × 10 13 cm. However, the post-maximum behavior of other UV-bright SNe Ia can also be modeled in a similar manner, including objects with UV spectroscopy or pre-maximum photometry which is inconsistent with this model. This suggests that similar UV luminosities can be intrinsic or caused by other forms of shock interaction. The high velocities reported for SN 2011de make it distinct from the UV-bright ''super-Chandrasekhar'' SNe Ia and the NUV-blue group of normal SNe Ia. SN 2011de is an extreme example of the UV variations in SNe Ia

Association between platelet glycoprotein Ia C807T gene polymorphism and ischemic stroke: a meta-analysis in a separate ethnic group.

Science.gov (United States)

Huang, Xiao-Yun; Fu, Wen-Jin; Mei, Zhi-Zhong; Yu, Ying-Li; Huang, Yi-Hong; Lin, Han; Chen, Jian-Jun; Wang, Ming-Xia; Guan, Shao-Bing; Fang, Hao-Wei

2017-11-30

Many studies have been examined the association of platelet glycoprotein (GP) Ia C807T polymorphism with ischemic stroke (IS) susceptibility. However, the results of these studies are inconsistent. To further assess the effects of GP Ia C807T polymorphism on the risk of IS, a meta-analysis was performed in a separate ethnic group. Relevant studies were identified using PubMed and Chinese databases through January 2017. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. Finally, 13 studies contained 2438 IS cases and 2308 controls included. In the total analyses, a significantly elevated risk of IS was associated with all variants of GP Ia C807T in the Chinese population (T vs C: OR = 1.24, 95% CI = 1.09-1.40; TT vs CC: OR = 1.59, 95% CI = 1.17-2.15; TT and CT combined vs CC: OR = 1.32, 95% CI = 1.09-1.59; TT vs CC and CT: OR = 1.35, 95% CI = 1.04-1.76). In the subgroup analyses stratified by ethnicity and geographic areas, it revealed the significant results in Chinese Han and in South China. This meta-analysis provides the evidence that GP Ia C807T polymorphism may contribute to the IS development in the Chinese population, especially in South China, and further studies in other ethic groups are required for definite conclusions.

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding

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Ji Won Um

2016-02-01

Full Text Available The four members of the LRRTM family (LRRTM1-4 are postsynaptic adhesion molecules essential for excitatory synapse development. They have also been implicated in neuropsychiatric diseases. Here, we focus on LRRTM3, showing that two distinct LRRTM3 variants generated by alternative splicing regulate LRRTM3 interaction with PSD-95, but not its excitatory synapse-promoting activity. Overexpression of either LRRTM3 variant increased excitatory synapse density in dentate gyrus (DG granule neurons, whereas LRRTM3 knockdown decreased it. LRRTM3 also controlled activity-regulated AMPA receptor surface expression in an alternative splicing-dependent manner. Furthermore, Lrrtm3-knockout mice displayed specific alterations in excitatory synapse density, excitatory synaptic transmission and excitability in DG granule neurons but not in CA1 pyramidal neurons. Lastly, LRRTM3 required only specific splice variants of presynaptic neurexins for their synaptogenic activity. Collectively, our data highlight alternative splicing and differential presynaptic ligand utilization in the regulation of LRRTMs, revealing key regulatory mechanisms for excitatory synapse development.

Cataclysmic Variables as Supernova Ia Progenitors

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Stella Kafka

2012-06-01

Full Text Available Although the identification of the progenitors of type Ia supernovae (SNeIa remains controversial, it is generally accepted that they originate from binary star systems in which at least one component is a carbon-oxygen white dwarf (WD; those systems are grouped under the wide umbrella of cataclysmic variables. Current theories for SNeIa progenitors hold that, either via Roche lobe overflow of the companion or via a wind, the WD accumulates hydrogen or helium rich material which is then burned to C and O onto the WD’s surface. However, the specifics of this scenario are far from being understood or defined, allowing for a wealth of theories fighting for attention and a dearth of observations to support them. I discuss the latest attempts to identify and study those controversial SNeIa progenitors. I also introduce the most promising progenitor in hand and I present observational diagnostics that can reveal more members of the category.

Surface-bound capsular polysaccharide of type Ia group B Streptococcus mediates C1 binding and activation of the classic complement pathway

International Nuclear Information System (INIS)

Levy, N.J.; Kasper, D.L.

1986-01-01

The role of surface-bound type Ia group B Streptococcus (GBS) capsular polysaccharide in anti-body-independent binding of C1 and activation of the classic component pathway was investigated. In a radiolabeled bacterial-polymorphonuclear leukocyte (PMN) association assay, a measure of bacterial opsonization, preincubation of 3 H-type Ia GBS with purified F(ab') 2 to the organism blocked the association of the bacteria with PMN', and the inhibitory effect was dose dependent. The specificity of F(ab') 2 blocking was shown after adsorption of F(ab') 2 with type Ia polysaccharide-sensitized erythrocytes. Polysaccharide-adsorbed F(ab') 2 had a 70% decrease in ability to block the association of bacteria with PMN. Neuraminidase digestion removed 80% of the terminal sialic acid residues from the native polysaccharide. These neuraminidase-digested organisms had a 72% decrease in binding and transfer of purified C1 compared with non-enzyme-treated organisms. Type Ia capsular polysaccharide bound to sheep erythrocytes promoted classic complement pathway-mediated hemolysis of the cells. The role of C1 inhibitor (INH) in modulation of C1 activation by the organisms was investigated. The possibility existed that the C1 INH could be bound by the bacteria, allowing C1 activation to occur in the fluid phase. The inhibitor was purified from human serum, and its activity was measured before and after incubation with type Ia GBS. The organisms had no effect on C1 INH activity. Thus surface-bound capsular polysacchardie of type Ia GBS mediates C1 binding and classic pathway activation, and this does not involve the C1 INH

Cervical Cancer Stage IA

Science.gov (United States)

... historical Searches are case-insensitive Cervical Cancer Stage IA Add to My Pictures View /Download : Small: 720x576 ... Large: 3000x2400 View Download Title: Cervical Cancer Stage IA Description: Stage IA1 and IA2 cervical cancer; drawing ...

Constraining the Single-degenerate Channel of Type Ia Supernovae with Stable Iron-group Elements in SNR 3C 397

Energy Technology Data Exchange (ETDEWEB)

Dave, Pranav; Kashyap, Rahul; Fisher, Robert [Department of Physics, University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02740 (United States); Timmes, Frank [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287 (United States); Townsley, Dean [Department of Physics and Astronomy, Box 870324, University of Alabama, Tuscaloosa, AL 35487 (United States); Byrohl, Chris [Institut für Astrophysik, Georg August Universität Göttingen, Friedrich-Hund-Platz 1, D-37077 Göttingen (Germany)

2017-05-20

Recent Suzaku X-ray spectra of supernova remnant (SNR) 3C 397 indicate enhanced stable iron group element abundances of Ni, Mn, Cr, and Fe. Seeking to address key questions about the progenitor and explosion mechanism of 3C 397, we compute nucleosynthetic yields from a suite of multidimensional hydrodynamics models in the near-Chandrasekhar-mass, single-degenerate paradigm for Type Ia supernovae (SNe Ia). Varying the progenitor white dwarf (WD) internal structure, composition, ignition, and explosion mechanism, we find that the best match to the observed iron peak elements of 3C 397 are dense (central density ≥6 × 10{sup 9} g cm{sup −3}), low-carbon WDs that undergo a weak, centrally ignited deflagration, followed by a subsequent detonation. The amount of {sup 56}Ni produced is consistent with a normal or bright normal SNe Ia. A pure deflagration of a centrally ignited, low central density (≃2 × 10{sup 9} g cm{sup −3}) progenitor WD, frequently considered in the literature, is also found to produce good agreement with 3C 397 nucleosynthetic yields, but leads to a subluminous SN Ia event, in conflict with X-ray line width data. Additionally, in contrast to prior work that suggested a large supersolar metallicity for the WD progenitor for SNR 3C 397, we find satisfactory agreement for solar- and subsolar-metallicity progenitors. We discuss a range of implications our results have for the single-degenerate channel.

Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex

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Satoshi Kuroki

2018-03-01

Full Text Available Summary: Multisensory integration (MSI is a fundamental emergent property of the mammalian brain. During MSI, perceptual information encoded in patterned activity is processed in multimodal association cortex. The systems-level neuronal dynamics that coordinate MSI, however, are unknown. Here, we demonstrate intrinsic hub-like network activity in the association cortex that regulates MSI. We engineered calcium reporter mouse lines based on the fluorescence resonance energy transfer sensor yellow cameleon (YC2.60 expressed in excitatory or inhibitory neurons. In medial and parietal association cortex, we observed spontaneous slow waves that self-organized into hubs defined by long-range excitatory and local inhibitory circuits. Unlike directional source/sink-like flows in sensory areas, medial/parietal excitatory and inhibitory hubs had net-zero balanced inputs. Remarkably, multisensory stimulation triggered rapid phase-locking mainly of excitatory hub activity persisting for seconds after the stimulus offset. Therefore, association cortex tends to form balanced excitatory networks that configure slow-wave phase-locking for MSI. Video Abstract: : Kuroki et al. performed cell-type-specific, wide-field FRET-based calcium imaging to visualize cortical network activity induced by multisensory inputs. They observed phase-locking of cortical slow waves in excitatory neuronal hubs in association cortical areas that may underlie multisensory integration. Keywords: wide-field calcium imaging, multisensory integration, cortical slow waves, association cortex, phase locking, fluorescence resonance energy transfer, spontaneous activity, excitatory neuron, inhibitory neuron, mouse

Excitatory amino acid neurotoxicity and neurodegenerative disease.

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Meldrum, B; Garthwaite, J

1990-09-01

The progress over the last 30 years in defining the role of excitatory amino acids in normal physiological function and in the abnormal neuronal activity of epilepsy has been reviewed in earlier articles in this series. In the last five years it has become clear that excitatory amino acids also play a role in a wide range of neurodegenerative processes. The evidence is clearest where the degenerative process is acute, but is more controversial for slow degenerative processes. In this article Brian Meldrum and John Garthwaite review in vivo and in vitro studies of the cytotoxicity of amino acids and summarize the contribution of such toxicity to acute and chronic neurodegenerative disorders.

Computer simulations of neural mechanisms explaining upper and lower limb excitatory neural coupling

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Ferris Daniel P

2010-12-01

Full Text Available Abstract Background When humans perform rhythmic upper and lower limb locomotor-like movements, there is an excitatory effect of upper limb exertion on lower limb muscle recruitment. To investigate potential neural mechanisms for this behavioral observation, we developed computer simulations modeling interlimb neural pathways among central pattern generators. We hypothesized that enhancement of muscle recruitment from interlimb spinal mechanisms was not sufficient to explain muscle enhancement levels observed in experimental data. Methods We used Matsuoka oscillators for the central pattern generators (CPG and determined parameters that enhanced amplitudes of rhythmic steady state bursts. Potential mechanisms for output enhancement were excitatory and inhibitory sensory feedback gains, excitatory and inhibitory interlimb coupling gains, and coupling geometry. We first simulated the simplest case, a single CPG, and then expanded the model to have two CPGs and lastly four CPGs. In the two and four CPG models, the lower limb CPGs did not receive supraspinal input such that the only mechanisms available for enhancing output were interlimb coupling gains and sensory feedback gains. Results In a two-CPG model with inhibitory sensory feedback gains, only excitatory gains of ipsilateral flexor-extensor/extensor-flexor coupling produced reciprocal upper-lower limb bursts and enhanced output up to 26%. In a two-CPG model with excitatory sensory feedback gains, excitatory gains of contralateral flexor-flexor/extensor-extensor coupling produced reciprocal upper-lower limb bursts and enhanced output up to 100%. However, within a given excitatory sensory feedback gain, enhancement due to excitatory interlimb gains could only reach levels up to 20%. Interconnecting four CPGs to have ipsilateral flexor-extensor/extensor-flexor coupling, contralateral flexor-flexor/extensor-extensor coupling, and bilateral flexor-extensor/extensor-flexor coupling could enhance

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

DEFF Research Database (Denmark)

Jensen, Anders A.; Fahlke, Christoph; Bjørn-Yoshimoto, Walden Emil

2015-01-01

The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the ......The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations...

TYPE Ia SUPERNOVA CARBON FOOTPRINTS

International Nuclear Information System (INIS)

Thomas, R. C.; Nugent, P.; Aldering, G.; Aragon, C.; Bailey, S.; Childress, M.; Fakhouri, H. K.; Hsiao, E. Y.; Loken, S.; Antilogus, P.; Bongard, S.; Canto, A.; Baltay, C.; Buton, C.; Kerschhaggl, M.; Kowalski, M.; Paech, K.; Chotard, N.; Copin, Y.; Gangler, E.

2011-01-01

We present convincing evidence of unburned carbon at photospheric velocities in new observations of five Type Ia supernovae (SNe Ia) obtained by the Nearby Supernova Factory. These SNe are identified by examining 346 spectra from 124 SNe obtained before +2.5 days relative to maximum. Detections are based on the presence of relatively strong C II λ6580 absorption 'notches' in multiple spectra of each SN, aided by automated fitting with the SYNAPPS code. Four of the five SNe in question are otherwise spectroscopically unremarkable, with ions and ejection velocities typical of SNe Ia, but spectra of the fifth exhibit high-velocity (v > 20, 000 km s –1 ) Si II and Ca II features. On the other hand, the light curve properties are preferentially grouped, strongly suggesting a connection between carbon-positivity and broadband light curve/color behavior: three of the five have relatively narrow light curves but also blue colors and a fourth may be a dust-reddened member of this family. Accounting for signal to noise and phase, we estimate that 22 +10 –6% of SNe Ia exhibit spectroscopic C II signatures as late as –5 days with respect to maximum. We place these new objects in the context of previously recognized carbon-positive SNe Ia and consider reasonable scenarios seeking to explain a physical connection between light curve properties and the presence of photospheric carbon. We also examine the detailed evolution of the detected carbon signatures and the surrounding wavelength regions to shed light on the distribution of carbon in the ejecta. Our ability to reconstruct the C II λ6580 feature in detail under the assumption of purely spherical symmetry casts doubt on a 'carbon blobs' hypothesis, but does not rule out all asymmetric models. A low volume filling factor for carbon, combined with line-of-sight effects, seems unlikely to explain the scarcity of detected carbon in SNe Ia by itself.

Effects of Neuromodulation on Excitatory-Inhibitory Neural Network Dynamics Depend on Network Connectivity Structure

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Rich, Scott; Zochowski, Michal; Booth, Victoria

2018-01-01

Acetylcholine (ACh), one of the brain's most potent neuromodulators, can affect intrinsic neuron properties through blockade of an M-type potassium current. The effect of ACh on excitatory and inhibitory cells with this potassium channel modulates their membrane excitability, which in turn affects their tendency to synchronize in networks. Here, we study the resulting changes in dynamics in networks with inter-connected excitatory and inhibitory populations (E-I networks), which are ubiquitous in the brain. Utilizing biophysical models of E-I networks, we analyze how the network connectivity structure in terms of synaptic connectivity alters the influence of ACh on the generation of synchronous excitatory bursting. We investigate networks containing all combinations of excitatory and inhibitory cells with high (Type I properties) or low (Type II properties) modulatory tone. To vary network connectivity structure, we focus on the effects of the strengths of inter-connections between excitatory and inhibitory cells (E-I synapses and I-E synapses), and the strengths of intra-connections among excitatory cells (E-E synapses) and among inhibitory cells (I-I synapses). We show that the presence of ACh may or may not affect the generation of network synchrony depending on the network connectivity. Specifically, strong network inter-connectivity induces synchronous excitatory bursting regardless of the cellular propensity for synchronization, which aligns with predictions of the PING model. However, when a network's intra-connectivity dominates its inter-connectivity, the propensity for synchrony of either inhibitory or excitatory cells can determine the generation of network-wide bursting.

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

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Sonsalla, P K; Nicklas, W J; Heikkila, R E

1989-01-20

The systemic administration of either methamphetamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to experimental animals produces degenerative changes in nigrostriatal dopaminergic neurons or their axon terminals. This study was conducted to determine if excitatory amino acids, which appear to be involved in various neurodegenerative disorders, might also contribute to the dopaminergic neurotoxicity produced in mice by either methamphetamine or MPTP. MK-801, phencyclidine, and ketamine, noncompetitive antagonists of one subtype of excitatory amino acid receptor, the N-methyl-D-aspartate receptor, provided substantial protection against neurotoxicity produced by methamphetamine but not that produced by MPTP. These findings indicate that excitatory amino acids play an important role in the nigrostriatal dopaminergic damage induced by methamphetamine.

Type Ia Supernova Cosmology

Science.gov (United States)

Leibundgut, B.; Sullivan, M.

2018-03-01

The primary agent for Type Ia supernova cosmology is the uniformity of their appearance. We present the current status, achievements and uncertainties. The Hubble constant and the expansion history of the universe are key measurements provided by Type Ia supernovae. They were also instrumental in showing time dilation, which is a direct observational signature of expansion. Connections to explosion physics are made in the context of potential improvements of the quality of Type Ia supernovae as distance indicators. The coming years will see large efforts to use Type Ia supernovae to characterise dark energy.

Prepubertal growth in congenital disorder of glycosylation type Ia (CDG-Ia)

OpenAIRE

Kjaergaard, S; Muller, J; Skovby, F

2002-01-01

Aims: To delineate the pattern of growth in prepubertal children with congenital disorder of glycosylation type Ia (CDG-Ia) in order to identify critical period(s) and possible cause(s) of growth failure.

Rates and progenitors of type Ia supernovae

Energy Technology Data Exchange (ETDEWEB)

Wood-Vasey, William Michael [Univ. of California, Berkeley, CA (United States)

2004-01-01

The remarkable uniformity of Type Ia supernovae has allowed astronomers to use them as distance indicators to measure the properties and expansion history of the Universe. However, Type Ia supernovae exhibit intrinsic variation in both their spectra and observed brightness. The brightness variations have been approximately corrected by various methods, but there remain intrinsic variations that limit the statistical power of current and future observations of distant supernovae for cosmological purposes. There may be systematic effects in this residual variation that evolve with redshift and thus limit the cosmological power of SN Ia luminosity-distance experiments. To reduce these systematic uncertainties, we need a deeper understanding of the observed variations in Type Ia supernovae. Toward this end, the Nearby Supernova Factory has been designed to discover hundreds of Type Ia supernovae in a systematic and automated fashion and study them in detail. This project will observe these supernovae spectrophotometrically to provide the homogeneous high-quality data set necessary to improve the understanding and calibration of these vital cosmological yardsticks. From 1998 to 2003, in collaboration with the Near-Earth Asteroid Tracking group at the Jet Propulsion Laboratory, a systematic and automated searching program was conceived and executed using the computing facilities at Lawrence Berkeley National Laboratory and the National Energy Research Supercomputing Center. An automated search had never been attempted on this scale. A number of planned future large supernovae projects are predicated on the ability to find supernovae quickly, reliably, and efficiently in large datasets. A prototype run of the SNfactory search pipeline conducted from 2002 to 2003 discovered 83 SNe at a final rate of 12 SNe/month. A large, homogeneous search of this scale offers an excellent opportunity to measure the rate of Type Ia supernovae. This thesis presents a new method for

Rates and progenitors of type Ia supernovae

International Nuclear Information System (INIS)

Wood-Vasey, William Michael

2004-01-01

The remarkable uniformity of Type Ia supernovae has allowed astronomers to use them as distance indicators to measure the properties and expansion history of the Universe. However, Type Ia supernovae exhibit intrinsic variation in both their spectra and observed brightness. The brightness variations have been approximately corrected by various methods, but there remain intrinsic variations that limit the statistical power of current and future observations of distant supernovae for cosmological purposes. There may be systematic effects in this residual variation that evolve with redshift and thus limit the cosmological power of SN Ia luminosity-distance experiments. To reduce these systematic uncertainties, we need a deeper understanding of the observed variations in Type Ia supernovae. Toward this end, the Nearby Supernova Factory has been designed to discover hundreds of Type Ia supernovae in a systematic and automated fashion and study them in detail. This project will observe these supernovae spectrophotometrically to provide the homogeneous high-quality data set necessary to improve the understanding and calibration of these vital cosmological yardsticks. From 1998 to 2003, in collaboration with the Near-Earth Asteroid Tracking group at the Jet Propulsion Laboratory, a systematic and automated searching program was conceived and executed using the computing facilities at Lawrence Berkeley National Laboratory and the National Energy Research Supercomputing Center. An automated search had never been attempted on this scale. A number of planned future large supernovae projects are predicated on the ability to find supernovae quickly, reliably, and efficiently in large datasets. A prototype run of the SNfactory search pipeline conducted from 2002 to 2003 discovered 83 SNe at a final rate of 12 SNe/month. A large, homogeneous search of this scale offers an excellent opportunity to measure the rate of Type Ia supernovae. This thesis presents a new method for

European freshwater VHSV genotype Ia isolates divide into two distinct subpopulations

DEFF Research Database (Denmark)

Kahns, Søren; Skall, Helle Frank; Kaas, Rolf Sommer

2012-01-01

Viral haemorrhagic septicaemia (VHS), caused by the novirhabdovirus VHSV, often leads to significant economic losses to European rainbow trout production. The virus isolates are divided into 4 distinct genotypes with additional subgroups including sublineage Ia, isolates of which are the main...... detected in Denmark since January 2009. Full-length G-genes of all Danish VHSV isolates that were submitted for diagnostic analyses in the period 2004−2009 were sequenced and analysed. All 58 Danish isolates from rainbow trout grouped with sublineage Ia isolates. Furthermore, VHSV isolates from infected...... Danish freshwater catchments appear to have evolved into a distinct clade within sublineage Ia, herein designated clade Ia-1, whereas trout isolates originating from other continental European countries cluster in another distinct clade, designated clade Ia-2. In addition, phylogenetic analyses indicate...

Maturation- and sex-sensitive depression of hippocampal excitatory transmission in a rat schizophrenia model.

Science.gov (United States)

Patrich, Eti; Piontkewitz, Yael; Peretz, Asher; Weiner, Ina; Attali, Bernard

2016-01-01

Schizophrenia is associated with behavioral and brain structural abnormalities, of which the hippocampus appears to be one of the most consistent region affected. Previous studies performed on the poly I:C model of schizophrenia suggest that alterations in hippocampal synaptic transmission and plasticity take place in the offspring. However, these investigations yielded conflicting results and the neurophysiological alterations responsible for these deficits are still unclear. Here we performed for the first time a longitudinal study examining the impact of prenatal poly I:C treatment and of gender on hippocampal excitatory neurotransmission. In addition, we examined the potential preventive/curative effects of risperidone (RIS) treatment during the peri-adolescence period. Excitatory synaptic transmission was determined by stimulating Schaffer collaterals and monitoring fiber volley amplitude and slope of field-EPSP (fEPSP) in CA1 pyramidal neurons in male and female offspring hippocampal slices from postnatal days (PNDs) 18-20, 34, 70 and 90. Depression of hippocampal excitatory transmission appeared at juvenile age in male offspring of the poly I:C group, while it expressed with a delay in female, manifesting at adulthood. In addition, a reduced hippocampal size was found in both adult male and female offspring of poly I:C treated dams. Treatment with RIS at the peri-adolescence period fully restored in males but partly repaired in females these deficiencies. A maturation- and sex-dependent decrease in hippocampal excitatory transmission occurs in the offspring of poly I:C treated pregnant mothers. Pharmacological intervention with RIS during peri-adolescence can cure in a gender-sensitive fashion early occurring hippocampal synaptic deficits. Copyright © 2015 Elsevier Inc. All rights reserved.

Bioengineered human IAS reconstructs with functional and molecular properties similar to intact IAS

Science.gov (United States)

Singh, Jagmohan

2012-01-01

Because of its critical importance in rectoanal incontinence, we determined the feasibility to reconstruct internal anal sphincter (IAS) from human IAS smooth muscle cells (SMCs) with functional and molecular attributes similar to the intact sphincter. The reconstructs were developed using SMCs from the circular smooth muscle layer of the human IAS, grown in smooth muscle differentiation media under sterile conditions in Sylgard-coated tissue culture plates with central Sylgard posts. The basal tone in the reconstructs and its changes were recorded following 0 Ca2+, KCl, bethanechol, isoproterenol, protein kinase C (PKC) activator phorbol 12,13-dibutyrate, and Rho kinase (ROCK) and PKC inhibitors Y-27632 and Gö-6850, respectively. Western blot (WB), immunofluorescence (IF), and immunocytochemical (IC) analyses were also performed. The reconstructs developed spontaneous tone (0.68 ± 0.26 mN). Bethanechol (a muscarinic agonist) and K+ depolarization produced contraction, whereas isoproterenol (β-adrenoceptor agonist) and Y-27632 produced a concentration-dependent decrease in the tone. Maximal decrease in basal tone with Y-27632 and Gö-6850 (each 10−5 M) was 80.45 ± 3.29 and 17.76 ± 3.50%, respectively. WB data with the IAS constructs′ SMCs revealed higher levels of RhoA/ROCK, protein kinase C-potentiated inhibitor or inhibitory phosphoprotein for myosin phosphatase (CPI-17), phospho-CPI-17, MYPT1, and 20-kDa myosin light chain vs. rectal smooth muscle. WB, IF, and IC studies of original SMCs and redispersed from the reconstructs for the relative distribution of different signal transduction proteins confirmed the feasibility of reconstruction of IAS with functional properties similar to intact IAS and demonstrated the development of myogenic tone with critical dependence on RhoA/ROCK. We conclude that it is feasible to bioengineer IAS constructs using human IAS SMCs that behave like intact IAS. PMID:22790596

Spatial distribution of excitatory synapses on the dendrites of ganglion cells in the mouse retina.

Directory of Open Access Journals (Sweden)

Yin-Peng Chen

Full Text Available Excitatory glutamatergic inputs from bipolar cells affect the physiological properties of ganglion cells in the mammalian retina. The spatial distribution of these excitatory synapses on the dendrites of retinal ganglion cells thus may shape their distinct functions. To visualize the spatial pattern of excitatory glutamatergic input into the ganglion cells in the mouse retina, particle-mediated gene transfer of plasmids expressing postsynaptic density 95-green fluorescent fusion protein (PSD95-GFP was used to label the excitatory synapses. Despite wide variation in the size and morphology of the retinal ganglion cells, the expression of PSD95 puncta was found to follow two general rules. Firstly, the PSD95 puncta are regularly spaced, at 1-2 µm intervals, along the dendrites, whereby the presence of an excitatory synapse creates an exclusion zone that rules out the presence of other glutamatergic synaptic inputs. Secondly, the spatial distribution of PSD95 puncta on the dendrites of diverse retinal ganglion cells are similar in that the number of excitatory synapses appears to be less on primary dendrites and to increase to a plateau on higher branch order dendrites. These observations suggest that synaptogenesis is spatially regulated along the dendritic segments and that the number of synaptic contacts is relatively constant beyond the primary dendrites. Interestingly, we also found that the linear puncta density is slightly higher in large cells than in small cells. This may suggest that retinal ganglion cells with a large dendritic field tend to show an increased connectivity of excitatory synapses that makes up for their reduced dendrite density. Mapping the spatial distribution pattern of the excitatory synapses on retinal ganglion cells thus provides explicit structural information that is essential for our understanding of how excitatory glutamatergic inputs shape neuronal responses.

PROMPT Ia SUPERNOVAE ARE SIGNIFICANTLY DELAYED

International Nuclear Information System (INIS)

Raskin, Cody; Scannapieco, Evan; Rhoads, James; Della Valle, Massimo

2009-01-01

The time delay between the formation of a population of stars and the onset of type Ia supernovae (SNe Ia) sets important limits on the masses and nature of SN Ia progenitors. Here, we use a new observational technique to measure this time delay by comparing the spatial distributions of SNe Ia to their local environments. Previous work attempted such analyses encompassing the entire host of each SN Ia, yielding inconclusive results. Our approach confines the analysis only to the relevant portions of the hosts, allowing us to show that even so-called prompt SNe Ia that trace star formation on cosmic timescales exhibit a significant delay time of 200-500 million years. This implies that either the majority of Ia companion stars have main-sequence masses less than 3 M sun , or that most SNe Ia arise from double white dwarf binaries. Our results are also consistent with a SNe Ia rate that traces the white dwarf formation rate, scaled by a fixed efficiency factor.

Degree of synchronization modulated by inhibitory neurons in clustered excitatory-inhibitory recurrent networks

Science.gov (United States)

Li, Huiyan; Sun, Xiaojuan; Xiao, Jinghua

2018-01-01

An excitatory-inhibitory recurrent neuronal network is established to numerically study the effect of inhibitory neurons on the synchronization degree of neuronal systems. The obtained results show that, with the number of inhibitory neurons and the coupling strength from an inhibitory neuron to an excitatory neuron increasing, inhibitory neurons can not only reduce the synchronization degree when the synchronization degree of the excitatory population is initially higher, but also enhance it when it is initially lower. Meanwhile, inhibitory neurons could also help the neuronal networks to maintain moderate synchronized states. In this paper, we call this effect as modulation effect of inhibitory neurons. With the obtained results, it is further revealed that the ratio of excitatory neurons to inhibitory neurons being nearly 4 : 1 is an economic and affordable choice for inhibitory neurons to realize this modulation effect.

Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development

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Cameron David A

2012-08-01

Full Text Available Abstract Background Cortical neurons display dynamic patterns of gene expression during the coincident processes of differentiation and migration through the developing cerebrum. To identify genes selectively expressed by the Eomes + (Tbr2 lineage of excitatory cortical neurons, GFP-expressing cells from Tg(Eomes::eGFP Gsat embryos were isolated to > 99% purity and profiled. Results We report the identification, validation and spatial grouping of genes selectively expressed within the Eomes + cortical excitatory neuron lineage during early cortical development. In these neurons 475 genes were expressed ≥ 3-fold, and 534 genes ≤ 3-fold, compared to the reference population of neuronal precursors. Of the up-regulated genes, 328 were represented at the Genepaint in situ hybridization database and 317 (97% were validated as having spatial expression patterns consistent with the lineage of differentiating excitatory neurons. A novel approach for quantifying in situ hybridization patterns (QISP across the cerebral wall was developed that allowed the hierarchical clustering of genes into putative co-regulated groups. Forty four candidate genes were identified that show spatial expression with Intermediate Precursor Cells, 49 candidate genes show spatial expression with Multipolar Neurons, while the remaining 224 genes achieved peak expression in the developing cortical plate. Conclusions This analysis of differentiating excitatory neurons revealed the expression patterns of 37 transcription factors, many chemotropic signaling molecules (including the Semaphorin, Netrin and Slit signaling pathways, and unexpected evidence for non-canonical neurotransmitter signaling and changes in mechanisms of glucose metabolism. Over half of the 317 identified genes are associated with neuronal disease making these findings a valuable resource for studies of neurological development and disease.

Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7.

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Terauchi, Akiko; Timmons, Kendall M; Kikuma, Koto; Pechmann, Yvonne; Kneussel, Matthias; Umemori, Hisashi

2015-01-15

Specific formation of excitatory and inhibitory synapses is crucial for proper functioning of the brain. Fibroblast growth factor 22 (FGF22) and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and inhibitory presynaptic differentiation, respectively, in the hippocampus. For the establishment of specific synaptic networks, these FGFs must localize to appropriate synaptic locations - FGF22 to excitatory and FGF7 to inhibitory postsynaptic sites. Here, we show that distinct motor and adaptor proteins contribute to intracellular microtubule transport of FGF22 and FGF7. Excitatory synaptic targeting of FGF22 requires the motor proteins KIF3A and KIF17 and the adaptor protein SAP102 (also known as DLG3). By contrast, inhibitory synaptic targeting of FGF7 requires the motor KIF5 and the adaptor gephyrin. Time-lapse imaging shows that FGF22 moves with SAP102, whereas FGF7 moves with gephyrin. These results reveal the basis of selective targeting of the excitatory and inhibitory presynaptic organizers that supports their different synaptogenic functions. Finally, we found that knockdown of SAP102 or PSD95 (also known as DLG4), which impairs the differentiation of excitatory synapses, alters FGF7 localization, suggesting that signals from excitatory synapses might regulate inhibitory synapse formation by controlling the distribution of the inhibitory presynaptic organizer. © 2015. Published by The Company of Biologists Ltd.

Effect of calcium on excitatory neuromuscular transmission in the crayfish

Science.gov (United States)

Bracho, H.; Orkand, R. K.

1970-01-01

1. The effects of varying the external Ca concentration from 1·8 to 30 mM/l. (⅛-2 times normal) have been studied at the in vitro crayfish excitatory neuromuscular junction. Electrophysiological techniques were used to record transmembrane junctional potentials from muscle fibres and extracellular junctional currents from the vicinity of nerve terminals. 2. The excitatory junctional potential amplitude was proportional to [Ca]0n, where n varied between 0·68 and 0·94 (mean 0·82) when [Ca]0 was varied from 1·8 to 15 mM/l. 3. The increase in junctional potential amplitude on raising [Ca]0 resulted primarily from an increase in the average number of quanta of excitatory transmitter released from the presynaptic nerve terminal by the nerve impulse. 4. The size of the quanta, synaptic delay, presynaptic potential and electrical properties of the muscle membrane were little affected by changes in calcium concentration in the range studied. PMID:5498460

Excitatory components of the mammalian locomotor CPG

DEFF Research Database (Denmark)

Kiehn, Ole; Quinlan, Katharina A.; Restrepo, Carlos Ernesto

2008-01-01

Locomotion in mammals is to a large degree controlled directly by intrinsic spinal networks, called central pattern generators (CPGs). The overall function of these networks is governed by interaction between inhibitory and excitatory neurons. In the present review, we will discuss recent finding...

Do personality traits predict individual differences in excitatory and inhibitory learning?

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Zhimin eHe

2013-05-01

Full Text Available Conditioned inhibition (CI is demonstrated in classical conditioning when a stimulus is used to signal the omission of an otherwise expected outcome. This basic learning ability is involved in a wide range of normal behaviour - and thus its disruption could produce a correspondingly wide range of behavioural deficits. The present study employed a computer-based task to measure conditioned excitation and inhibition in the same discrimination procedure. Conditioned inhibition by summation test was clearly demonstrated. Additionally summary measures of excitatory and inhibitory learning (difference scores were calculated in order to explore how performance related to individual differences in a large sample of normal participants (n=176 following exclusion of those not meeting the basic learning criterion. The individual difference measures selected derive from two biologically-based personality theories, Gray’s reinforcement sensitivity theory (1982 and Eysenck’s psychoticism, extraversion and neuroticism theory (1991. Following the behavioural tasks, participants completed the behavioural inhibition system/behavioural activation system scales (BIS/BAS and the Eysenck personality questionnaire revised short scale (EPQ-RS. Analyses of the relationship between scores on each of the scales and summary measures of excitatory and inhibitory learning suggested that those with higher BAS (specifically the drive sub-scale and higher EPQ-RS neuroticism showed reduced levels of excitatory conditioning. Inhibitory conditioning was similarly attenuated in those with higher EPQ-RS neuroticism, as well as in those with higher BIS scores. Thus the findings are consistent with higher levels of neuroticism being accompanied by generally impaired associative learning, both inhibitory and excitatory. There was also evidence for some dissociation in the effects of behavioural activation and behavioural inhibition on excitatory and inhibitory learning respectively.

Modulation of macrophage Ia expression by lipopolysaccharide: Stem cell requirements, accessory lymphocyte involvement, and IA-inducing factor production

International Nuclear Information System (INIS)

Wentworth, P.A.; Ziegler, H.K.

1989-01-01

The mechanism of induction of murine macrophage Ia expression by lipopolysaccharide (LPS) was studied. Intraperitoneal injection of 1 microgram of LPS resulted in a 3- to 10-fold increase in the number of IA-positive peritoneal macrophages (flow cytometry and immunofluorescence) and a 6-to 16-fold increase by radioimmunoassay. The isolated lipid A moiety of LPS was a potent inducer of macrophage Ia expression. Ia induction required a functional myelopoietic system as indicated by the finding that the response to LPS was eliminated in irradiated (900 rads) mice and reinstated by reconstitution with bone marrow cells. Comparison of LPS-induced Ia expression in normal and LPS-primed mice revealed a faster secondary response to LPS. The memory response could be adoptively transferred to normal mice with nonadherent spleen cells prepared 60 days after LPS injection. Spleen cells prepared 5 days after LPS injection caused Ia induction in LPS-nonresponder mice; such induction was not observed in irradiated (900 rads) recipients. The cell responsible for this phenomenon was identified as a Thy-1+, immunoglobulin-negative nonadherent cell. The biosynthesis and expression of Ia were not increased by direct exposure of macrophages to LPS in vitro. Small amounts of LPS inhibited Ia induction by gamma interferon. LPS showed positive regulatory effects on Ia expression by delaying the loss of Ia expression on cultured macrophages and by stimulating the production of Ia-inducing factors. Supernatants from cultured spleen cells stimulated with LPS in vitro contained antiviral and Ia-inducing activity that was acid labile, indicating that the active factor is gamma interferon. We conclude that induction of Ia expression by LPS in vivo is a bone-marrow-dependent, radiation-sensitive process which involves the stimulation of a gamma interferon-producing accessory lymphocyte and a delay in Ia turnover

Electrical field stimulation-induced excitatory responses of ...

African Journals Online (AJOL)

effect of the endothelium on electrical field stimulation (EFS)-induced excitatory responses of pulmonary artery segments from pulmonary hypertensive rats. Methods: Pulmonary hypertension was induced in rats with a single dose of monocrotaline (60 mg/kg) and 21 days later, arterial rings were set up for isometric tension ...

Ia Afferent input alters the recruitment thresholds and firing rates of single human motor units.

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Grande, G; Cafarelli, E

2003-06-01

Vibration of the patellar tendon recruits motor units in the knee extensors via excitation of muscle spindles and subsequent Ia afferent input to the alpha-motoneuron pool. Our first purpose was to determine if the recruitment threshold and firing rate of the same motor unit differed when recruited involuntarily via reflex or voluntarily via descending spinal pathways. Although Ia input is excitatory to the alpha-motoneuron pool, it has also been shown paradoxically to inhibit itself. Our second purpose was to determine if vibration of the patellar tendon during a voluntary knee extension causes a change in the firing rate of already recruited motor units. In the first protocol, 10 subjects voluntarily reproduced the same isometric force profile of the knee extensors that was elicited by vibration of the patellar tendon. Single motor unit recordings from the vastus lateralis (VL) were obtained with tungsten microelectrodes and unitary behaviour was examined during both reflex and voluntary knee extensions. Recordings from 135 single motor units showed that both recruitment thresholds and firing rates were lower during reflex contractions. In the second protocol, 7 subjects maintained a voluntary knee extension at 30 N for approximately 40-45 s. Three bursts of patellar tendon vibration were superimposed at regular intervals throughout the contraction and changes in the firing rate of already recruited motor units were examined. A total of 35 motor units were recorded and each burst of superimposed vibration caused a momentary reduction in the firing rates and recruitment of additional units. Our data provide evidence that Ia input modulates the recruitment thresholds and firing rates of motor units providing more flexibility within the neuromuscular system to grade force at low levels of force production.

Sequential dynamics in the motif of excitatory coupled elements

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Korotkov, Alexander G.; Kazakov, Alexey O.; Osipov, Grigory V.

2015-11-01

In this article a new model of motif (small ensemble) of neuron-like elements is proposed. It is built with the use of the generalized Lotka-Volterra model with excitatory couplings. The main motivation for this work comes from the problems of neuroscience where excitatory couplings are proved to be the predominant type of interaction between neurons of the brain. In this paper it is shown that there are two modes depending on the type of coupling between the elements: the mode with a stable heteroclinic cycle and the mode with a stable limit cycle. Our second goal is to examine the chaotic dynamics of the generalized three-dimensional Lotka-Volterra model.

Dark Matter Ignition of Type Ia Supernovae.

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Bramante, Joseph

2015-10-02

Recent studies of low redshift type Ia supernovae (SN Ia) indicate that half explode from less than Chandrasekhar mass white dwarfs, implying ignition must proceed from something besides the canonical criticality of Chandrasekhar mass SN Ia progenitors. We show that 1-100 PeV mass asymmetric dark matter, with imminently detectable nucleon scattering interactions, can accumulate to the point of self-gravitation in a white dwarf and collapse, shedding gravitational potential energy by scattering off nuclei, thereby heating the white dwarf and igniting the flame front that precedes SN Ia. We combine data on SN Ia masses with data on the ages of SN Ia-adjacent stars. This combination reveals a 2.8σ inverse correlation between SN Ia masses and ignition ages, which could result from increased capture of dark matter in 1.4 vs 1.1 solar mass white dwarfs. Future studies of SN Ia in galactic centers will provide additional tests of dark-matter-induced type Ia ignition. Remarkably, both bosonic and fermionic SN Ia-igniting dark matter also resolve the missing pulsar problem by forming black holes in ≳10  Myr old pulsars at the center of the Milky Way.

Excitatory amino acid transporters as potential drug targets

DEFF Research Database (Denmark)

Bunch, Lennart; Erichsen, Mette Navy; Jensen, Anders Asbjørn

2009-01-01

BACKGROUND: Excitatory amino acid transporters (EAATs) are transmembrane proteins responsible for the uptake of (S)-glutamate (Glu) from the synaptic cleft, thereby terminating the glutamatergic neurotransmitter signal. Today five subtypes have been identified. Except for EAAT2, their individual...

The 'grey' assessment practice of IA screening

DEFF Research Database (Denmark)

Bidstrup, Morten

2017-01-01

Research focusing on the practices surrounding screening in Impact Assessment (IA) is limited. Yet, it has been found that development proposals sometimes are adjusted through an informal dialog with IA practitioners prior to or during screening. Such practice is often referred to as ‘grey IA......’ in Denmark. This article explores the prevalence, influence and applied rationale of grey IA. Through a questionnaire, data was collected from 121 IA practitioners working within the fields of environmental impact assessment and strategic environmental assessment. It was found that grey IA is a common...... practice, which influences the outcomes of formal screening procedures through consideration of impacts on neighbours and spatial zones of protection. Grey IA is to some extent motivated by the opportunity to save the resources required for full-scale IA, but an additional ‘green’ rationale also exists...

The importance of the excitatory amino acid transporter 3 (EAAT3)

DEFF Research Database (Denmark)

E. Bjørn-Yoshimoto, Walden; Underhill, Suzanne M.

2016-01-01

Abstract The neuronal excitatory amino acid transporter 3 (EAAT3) is fairly ubiquitously expressed in the brain, though it does not necessarily maintain the same function everywhere. It is important in maintaining low local concentrations of glutamate, where its predominant post-synaptic localiza......Abstract The neuronal excitatory amino acid transporter 3 (EAAT3) is fairly ubiquitously expressed in the brain, though it does not necessarily maintain the same function everywhere. It is important in maintaining low local concentrations of glutamate, where its predominant post...

An Analysis of Department of Defense Instruction 8500.2 'Information Assurance (IA) Implementation.'

Energy Technology Data Exchange (ETDEWEB)

Campbell, Philip LaRoche

2012-01-01

The Department of Defense (DoD) provides its standard for information assurance in its Instruction 8500.2, dated February 6, 2003. This Instruction lists 157 'IA Controls' for nine 'baseline IA levels.' Aside from distinguishing IA Controls that call for elevated levels of 'robustness' and grouping the IA Controls into eight 'subject areas' 8500.2 does not examine the nature of this set of controls, determining, for example, which controls do not vary in robustness, how this set of controls compares with other such sets, or even which controls are required for all nine baseline IA levels. This report analyzes (1) the IA Controls, (2) the subject areas, and (3) the Baseline IA levels. For example, this report notes that there are only 109 core IA Controls (which this report refers to as 'ICGs'), that 43 of these core IA Controls apply without variation to all nine baseline IA levels and that an additional 31 apply with variations. This report maps the IA Controls of 8500.2 to the controls in NIST 800-53 and ITGI's CoBIT. The result of this analysis and mapping, as shown in this report, serves as a companion to 8500.2. (An electronic spreadsheet accompanies this report.)

Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites.

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Bardia F Behabadi

Full Text Available Neocortical pyramidal neurons (PNs receive thousands of excitatory synaptic contacts on their basal dendrites. Some act as classical driver inputs while others are thought to modulate PN responses based on sensory or behavioral context, but the biophysical mechanisms that mediate classical-contextual interactions in these dendrites remain poorly understood. We hypothesized that if two excitatory pathways bias their synaptic projections towards proximal vs. distal ends of the basal branches, the very different local spike thresholds and attenuation factors for inputs near and far from the soma might provide the basis for a classical-contextual functional asymmetry. Supporting this possibility, we found both in compartmental models and electrophysiological recordings in brain slices that the responses of basal dendrites to spatially separated inputs are indeed strongly asymmetric. Distal excitation lowers the local spike threshold for more proximal inputs, while having little effect on peak responses at the soma. In contrast, proximal excitation lowers the threshold, but also substantially increases the gain of distally-driven responses. Our findings support the view that PN basal dendrites possess significant analog computing capabilities, and suggest that the diverse forms of nonlinear response modulation seen in the neocortex, including uni-modal, cross-modal, and attentional effects, could depend in part on pathway-specific biases in the spatial distribution of excitatory synaptic contacts onto PN basal dendritic arbors.

THE AGES OF TYPE Ia SUPERNOVA PROGENITORS

International Nuclear Information System (INIS)

Brandt, Timothy D.; Aubourg, Eric; Strauss, Michael A.; Tojeiro, Rita; Heavens, Alan; Jimenez, Raul

2010-01-01

Using light curves and host galaxy spectra of 101 Type Ia supernovae (SNe Ia) with redshift z ∼ 2.4 Gyr. We find that each channel contributes roughly half of the Type Ia rate in our reference sample. We also construct the average spectra of high-stretch and low-stretch SN Ia host galaxies, and find that the difference of these spectra looks like a main-sequence B star with nebular emission lines indicative of star formation. This supports our finding that there are two populations of SNe Ia, and indicates that the progenitors of high-stretch supernovae are at the least associated with very recent star formation in the last few tens of Myr. Our results provide valuable constraints for models of Type Ia progenitors and may help improve the calibration of SNe Ia as standard candles.

The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning.

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Carmona, G N; Nishimura, T; Schindler, C W; Panlilio, L V; Notkins, A L

2014-06-06

The islet-antigens IA-2 and IA-2β are major autoantigens in type-1 diabetes and transmembrane proteins in dense core vesicles (DCV). Recently we showed that deletion of both IA-2 and IA-2β alters the secretion of hormones and neurotransmitters and impairs behavior and learning. The present study was designed to evaluate the contribution to learning of each of these genes by using single knockout (SKO) and double knockout (DKO) mice in an active avoidance test. After 5 days of training, wild-type (WT) mice showed 60-70% active avoidance responses, whereas the DKO mice showed only 10-15% active avoidance responses. The degree of active avoidance responses in the IA-2 SKO mice was similar to that of the DKO mice, but in contrast, the IA-2β SKO mice behaved like WT mice showing 60-70% active avoidance responses. Molecular studies revealed a marked decrease in the phosphorylation of the cAMP response element-binding protein (CREB) and Ca(2+)/calmodulin-dependent protein kinase II (CAMKII) in the striatum and hippocampus of the IA-2 SKO and DKO mice, but not in the IA-2β SKO mice. To evaluate the role of CREB and CAMKII in the SKO and DKO mice, GBR-12909, which selectively blocks the dopamine uptake transporter and increases CREB and CAMKII phosphorylation, was administered. GBR-12909 restored the phosphorylation of CREB and CAMKII and increased active avoidance learning in the DKO and IA-2 SKO to near the normal levels found in the WT and IA-2β SKO mice. We conclude that in the absence of the DCV protein IA-2, active avoidance learning is impaired. Published by Elsevier Ltd.

Constraining cosmological parameter with SN Ia

International Nuclear Information System (INIS)

Putri, A N Indra; Wulandari, H R Tri

2016-01-01

A type I supemovae (SN Ia) is an exploding white dwarf, whose mass exceeds Chandrasekar limit (1.44 solar mass). If a white dwarf is in a binary system, it may accrete matter from the companion, resulting in an excess mass that cannot be balanced by the pressure of degenerated electrons in the core. SNe Ia are highly luminous objects, that they are visible from very high distances. After some corrections (stretch (s), colour (c), K-corrections, etc.), the variations in the light curves of SNe Ia can be suppressed to be no more than 10%. Their high luminosity and almost uniform intrinsic brightness at the peak light, i.e. M B ∼ -19, make SNe Ia ideal standard candle. Because of their visibility from large distances, SNe Ia can be employed as a cosmological measuring tool. It was analysis of SNe Ia data that indicated for the first time, that the universe is not only expanding, but also accelerating. This work analyzed a compilation of SNe Ia data to determine several cosmological parameters (H 0 , Ω m , Ω a , and w ). It can be concluded from the analysis, that our universe is a flat, dark energy dominated universe, and that the cosmological constant A is a suitable candidate for dark energy. (paper)

Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models

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Cheryl L Gatto

2010-06-01

Full Text Available Proper brain function requires stringent balance of excitatory and inhibitory synapse formation during neural circuit assembly. Mutation of genes that normally sculpt and maintain this balance results in severe dysfunction, causing neurodevelopmental disorders including autism, epilepsy and Rett syndrome. Such mutations may result in defective architectural structuring of synaptic connections, molecular assembly of synapses and/or functional synaptogenesis. The affected genes often encode synaptic components directly, but also include regulators that secondarily mediate the synthesis or assembly of synaptic proteins. The prime example is Fragile X syndrome (FXS, the leading heritable cause of both intellectual disability and autism spectrum disorders. FXS results from loss of mRNA-binding FMRP, which regulates synaptic transcript trafficking, stability and translation in activity-dependent synaptogenesis and plasticity mechanisms. Genetic models of FXS exhibit striking excitatory and inhibitory synapse imbalance, associated with impaired cognitive and social interaction behaviors. Downstream of translation control, a number of specific synaptic proteins regulate excitatory versus inhibitory synaptogenesis, independently or combinatorially, and loss of these proteins is also linked to disrupted neurodevelopment. The current effort is to define the cascade of events linking transcription, translation and the role of specific synaptic proteins in the maintenance of excitatory versus inhibitory synapses during neural circuit formation. This focus includes mechanisms that fine-tune excitation and inhibition during the refinement of functional synaptic circuits, and later modulate this balance throughout life. The use of powerful new genetic models has begun to shed light on the mechanistic bases of excitation/inhibition imbalance for a range of neurodevelopmental disease states.

Physics of type Ia supernovae

International Nuclear Information System (INIS)

Hoeflich, Peter

2006-01-01

The last decade has witnessed an explosive growth of high-quality data for thermonuclear explosions of a white dwarf star, the type Ia supernovae (SNe Ia). Advances in computational methods provide new insights into the physics of the phenomenon and a direct, quantitative link between observables and explosion physics. Both trends combined provided spectacular results, allowed to address, to identify specific problems and to narrow down the range of scenarios. Current topics include the relation between SNe Ia and their progenitors, the influence of the metallicities and accretion on the explosion, and details of the burning front. How can we understand the apparent homogeneity and probe for the diversity of SNe Ia? Here, we want give an overview of the current status of our understanding of supernovae physics in light of recent results

Miniature excitatory synaptic currents in cultured hippocampal neurons.

Science.gov (United States)

Finch, D M; Fisher, R S; Jackson, M B

1990-06-04

We performed patch clamp recordings in the whole cell mode from cultured embryonic mouse hippocampal neurons. In bathing solutions containing tetrodotoxin (TTX), the cells showed spontaneous inward currents (SICs) ranging in size from 1 to 100 pA. Several observations indicated that the SICs were miniature excitatory synaptic currents mediated primarily by non-NMDA (N-methyl-D-aspartate) excitatory amino acid receptors: the rising phase of SICs was fast (1 ms to half amplitude at room temperature) and smooth, suggesting unitary events. The SICs were blocked by the broad-spectrum glutamate receptor antagonist gamma-D-glutamylglycine (DGG), but not by the selective NMDA-receptor antagonist D-2-amino-5-phosphonovaleric acid (5-APV). SICs were also blocked by desensitizing concentrations of quisqualate. Incubating cells in tetanus toxin, which blocks exocytotic transmitter release, eliminated SICs. The presence of SICs was consistent with the morphological arrangement of glutamatergic innervation in the cell cultures demonstrated immunohistochemically. Spontaneous outward currents (SOCs) were blocked by bicuculline and presumed to be mediated by GABAA receptors. This is consistent with immunohistochemical demonstration of GABAergic synapses. SIC frequency was increased in a calcium dependent manner by bathing the cells in a solution high in K+, and application of the dihydropyridine L-type calcium channel agonist BAY K 8644 increased the frequency of SICs. Increases in SIC frequency produced by high K+ solutions were reversed by Cd2+ and omega-conotoxin GVIA, but not by the selective L-type channel antagonist nimodipine. This suggested that presynaptic L-type channels were in a gating mode that was not blocked by nimodipine, and/or that another class of calcium channel makes a dominant contribution to excitatory transmitter release.

Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse.

Science.gov (United States)

Caldeira, Vanessa; Dougherty, Kimberly J; Borgius, Lotta; Kiehn, Ole

2017-01-27

Rhythm generating neurons are thought to be ipsilaterally-projecting excitatory neurons in the thoracolumbar mammalian spinal cord. Recently, a subset of Shox2 interneurons (Shox2 non-V2a INs) was found to fulfill these criteria and make up a fraction of the rhythm-generating population. Here we use Hb9::Cre mice to genetically manipulate Hb9::Cre-derived excitatory interneurons (INs) in order to determine the role of these INs in rhythm generation. We demonstrate that this line captures a consistent population of spinal INs which is mixed with respect to neurotransmitter phenotype and progenitor domain, but does not overlap with the Shox2 non-V2a population. We also show that Hb9::Cre-derived INs include the comparatively small medial population of INs which continues to express Hb9 postnatally. When excitatory neurotransmission is selectively blocked by deleting Vglut2 from Hb9::Cre-derived INs, there is no difference in left-right and/or flexor-extensor phasing between these cords and controls, suggesting that excitatory Hb9::Cre-derived INs do not affect pattern generation. In contrast, the frequencies of locomotor activity are significantly lower in cords from Hb9::Cre-Vglut2 Δ/Δ mice than in cords from controls. Collectively, our findings indicate that excitatory Hb9::Cre-derived INs constitute a distinct population of neurons that participates in the rhythm generating kernel for spinal locomotion.

Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs.

Science.gov (United States)

Spiegel, Ivo; Mardinly, Alan R; Gabel, Harrison W; Bazinet, Jeremy E; Couch, Cameron H; Tzeng, Christopher P; Harmin, David A; Greenberg, Michael E

2014-05-22

The nervous system adapts to experience by inducing a transcriptional program that controls important aspects of synaptic plasticity. Although the molecular mechanisms of experience-dependent plasticity are well characterized in excitatory neurons, the mechanisms that regulate this process in inhibitory neurons are only poorly understood. Here, we describe a transcriptional program that is induced by neuronal activity in inhibitory neurons. We find that, while neuronal activity induces expression of early-response transcription factors such as Npas4 in both excitatory and inhibitory neurons, Npas4 activates distinct programs of late-response genes in inhibitory and excitatory neurons. These late-response genes differentially regulate synaptic input to these two types of neurons, promoting inhibition onto excitatory neurons while inducing excitation onto inhibitory neurons. These findings suggest that the functional outcomes of activity-induced transcriptional responses are adapted in a cell-type-specific manner to achieve a circuit-wide homeostatic response. Copyright © 2014 Elsevier Inc. All rights reserved.

Imprints of explosion conditions on late-time spectra of type Ia supernovae

Science.gov (United States)

Diamond, Tiara R.

Type Ia supernovae (SNe Ia) play a vital role in the discrimination of different cosmological models. These events have been shown to be standardizable based on properties of their light curves during the early-time photospheric phase. However, the distribution of types of progenitor system, the explosion trigger, and the physics of the explosion are still an active topic of discussion. The details of the progenitors and explosion may provide insight into the variation seen in Type Ia supernova light curves and spectra, and therefore, allow for additional methods of standardization among the group. Late-time near-infrared spectral observations for SNe Ia show numerous strong emission features of forbidden line transitions of cobalt and iron, tracing the central distribution of iron-group burning products. As the spectrum ages, the cobalt features fade as expected from the decay of 56Co to 56Fe. This work will show that the strong and isolated [Fe II] emission line at 1.644 mum provides a unique tool to analyze near-infrared spectra of SNe Ia. Several new methods of analysis will be demonstrated to determine some of the initial conditions of the system. The initial central density, rhoc, and the extent of mixing in the central regions of the explosion have signatures in the line profiles of late-time spectra. An embedded magnetic field, B, of the white dwarf can be determined using the evolution of the lines profiles. Currently magnetic field effects are not included in the hydrodynamics and radiation transport of simulations of SNe Ia. Normalization of spectra to the 1.644 mum line allows separation of features produced by stable versus unstable isotopes of iron group elements. Implications for potential progenitor systems, explosion mechanisms, and the origins and morphology of magnetic fields in SNe Ia, in addition to limitations of the method, are discussed. Observations of the late-time near-infrared emission spectrum at multiple epochs allow for the first ever

Type Ia supernovae, standardizable candles, and gravity

Science.gov (United States)

Wright, Bill S.; Li, Baojiu

2018-04-01

Type Ia supernovae (SNe Ia) are generally accepted to act as standardizable candles, and their use in cosmology led to the first confirmation of the as yet unexplained accelerated cosmic expansion. Many of the theoretical models to explain the cosmic acceleration assume modifications to Einsteinian general relativity which accelerate the expansion, but the question of whether such modifications also affect the ability of SNe Ia to be standardizable candles has rarely been addressed. This paper is an attempt to answer this question. For this we adopt a semianalytical model to calculate SNe Ia light curves in non-standard gravity. We use this model to show that the average rescaled intrinsic peak luminosity—a quantity that is assumed to be constant with redshift in standard analyses of Type Ia supernova (SN Ia) cosmology data—depends on the strength of gravity in the supernova's local environment because the latter determines the Chandrasekhar mass—the mass of the SN Ia's white dwarf progenitor right before the explosion. This means that SNe Ia are no longer standardizable candles in scenarios where the strength of gravity evolves over time, and therefore the cosmology implied by the existing SN Ia data will be different when analysed in the context of such models. As an example, we show that the observational SN Ia cosmology data can be fitted with both a model where (ΩM,ΩΛ)=(0.62 ,0.38 ) and Newton's constant G varies as G (z )=G0(1 +z )-1/4 and the standard model where (ΩM,ΩΛ)=(0.3 ,0.7 ) and G is constant, when the Universe is assumed to be flat.

Growth, immune responses and protection of Nile tilapia Oreochromis niloticus immunized with formalin-killed Streptococcus agalactiae serotype Ia and III vaccines

Directory of Open Access Journals (Sweden)

Atchariya Suwannasang

2017-08-01

Full Text Available The protective efficacy of formalin-killed Streptococcus agalactiae (Group B Streptococcus, GBS serotype Ia (GBS-Ia and III (GBS-III vaccines were assessed in Nile tilapia (Oreochromis niloticus. The fish with an average weight of 34.45± 0.08 g were immunized by intraperitoneal (i.p. injection with 4 different formalin-killed vaccines prepared from GBS-Ia (1x1010 CFU/mL, GBS-III (1x1010 CFU/mL, and combined GBS-Ia and GBS-III in an equal volume at final concentrations 1x1010 CFU/mL and 2x1010 CFU/mL in comparison with the non-immunized control group. At 2 and 4 weeks post vaccination, no significant differences were observed (p>0.05 among treatments in growth performance or haemato-immunological parameters, except the increased red blood cell at 2 weeks. Significantly increased antibody titers (p<0.05 against GBS-Ia and GBS-III antigens were noted in the groups immunized with homologous GBS vaccines, whereas the group reacted with heterologous GBS antigen showed less antibody titer as compared with the control group. The vaccination experiment indicated that i.p. injection of Nile tilapia with formalin-killed cells prepared from GBS-Ia or GBS-III provides significant protection, with relative percent survival (RPS value of 52.17 to 71.42%, against a challenge with the homologous serotype isolate, whereas the RPS in fish challenged with a heterologous serotype isolate varied from 20.00 to 53.57%. These results suggested that vaccines from either GBS-Ia or GBS-III have insufficient cross-protective efficacy against the other serotypes. However, a mixed vaccine produced from both GBS serotypes Ia and III provided significant protection with 65.00 to 95.66% RPS which could be an excellent vaccine to protect fish against streptococcosis caused by both GBS serotypes Ia and III.

THE LOCAL HOSTS OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Neill, James D.; Martin, D. Christopher; Barlow, Tom A.; Foster, Karl; Friedman, Peter G.; Morrissey, Patrick; Wyder, Ted K.; Sullivan, Mark; Howell, D. Andrew; Conley, Alex; Seibert, Mark; Madore, Barry F.; Neff, Susan G.; Schiminovich, David; Bianchi, Luciana; Donas, Jose; Milliard, Bruno; Heckman, Timothy M.; Lee, Young-Wook; Rich, R. Michael

2009-01-01

We use multi-wavelength, matched aperture, integrated photometry from the Galaxy Evolution Explorer (GALEX), the Sloan Digital Sky Survey, and the RC3 to estimate the physical properties of 166 nearby galaxies hosting 168 well-observed Type Ia supernovae (SNe Ia). The ultraviolet (UV) imaging of local SN Ia hosts from GALEX allows a direct comparison with higher-redshift hosts measured at optical wavelengths that correspond to the rest-frame UV. Our data corroborate well-known features that have been seen in other SN Ia samples. Specifically, hosts with active star formation produce brighter and slower SNe Ia on average, and hosts with luminosity-weighted ages older than 1 Gyr produce on average more faint, fast, and fewer bright, slow SNe Ia than younger hosts. New results include that in our sample, the faintest and fastest SNe Ia occur only in galaxies exceeding a stellar mass threshold of ∼10 10 M sun , leading us to conclude that their progenitors must arise in populations that are older and/or more metal rich than the general SN Ia population. A low host extinction subsample hints at a residual trend in peak luminosity with host age, after correcting for light-curve shape, giving the appearance that older hosts produce less-extincted SNe Ia on average. This has implications for cosmological fitting of SNe Ia, and suggests that host age could be useful as a parameter in the fitting. Converting host mass to metallicity and computing 56 Ni mass from the supernova light curves, we find that our local sample is consistent with a model that predicts a shallow trend between stellar metallicity and the 56 Ni mass that powers the explosion, but we cannot rule out the absence of a trend. We measure a correlation between 56 Ni mass and host age in the local universe that is shallower and not as significant as that seen at higher redshifts. The details of the age- 56 Ni mass correlations at low and higher redshift imply a luminosity-weighted age threshold of ∼3 Gyr

Pregnancies in glycogen storage disease type Ia

NARCIS (Netherlands)

Martens, Danielle H. J.; Rake, Jan Peter; Schwarz, Martin; Ullrich, Kurt; Weinstein, David A.; Merkel, Martin; Sauer, Pieter J. J.; Smit, G. Peter A.

OBJECTIVE: Reports on pregnancies in women with glycogen storage disease type Ia (GSD-Ia) are scarce. Because of improved life expectancy, pregnancy is becoming an important issue. We describe 15 pregnancies by focusing on dietary treatment, biochemical parameters, and GSD-Ia complications. STUDY

A COMPREHENSIVE PROGENITOR MODEL FOR SNe Ia

International Nuclear Information System (INIS)

Meng, X.; Yang, W.

2010-01-01

Although the nature of the progenitor of Type Ia supernovae (SNe Ia) is still unclear, the single-degenerate (SD) channel for the progenitor is currently accepted, in which a carbon-oxygen white dwarf (CO WD) accretes hydrogen-rich material from its companion, increases its mass to the Chandrasekhar mass limit, and then explodes as an SN Ia. The companion may be a main sequence or a slightly evolved star (WD + MS), or a red giant star (WD + RG). Incorporating the effect of mass stripping and accretion-disk instability on the evolution of the WD binary, we carried out binary stellar evolution calculations for more than 1600 close WD binaries. As a result, the initial parameter spaces for SNe Ia are presented in an orbital period-secondary mass (log P i , M i 2 ) plane. We confirmed that in a WD + MS system, the initial companion leading to SNe Ia may have mass from 1 M sun to 5 M sun . The initial WD mass for SNe Ia from WD + MS channel is as low as 0.565 M sun , while the lowest WD mass from the WD + RG channel is 1.0 M sun . Adopting the above results, we studied the birth rate of SNe Ia via a binary population synthesis approach. We found that the Galactic SNe Ia birth rate from SD model is (2.55-2.9) x 10 -3 yr -1 (including WD + He star channel), which is slightly smaller than that from observation. If a single starburst is assumed, the distribution of the delay time of SNe Ia from the SD model may be a weak bimodality, where WD + He channel contributes to SNe Ia with delay time shorter than 10 8 yr and WD + RG channel to those with age longer than 6 Gyr.

Schaffer collateral inputs to CA1 excitatory and inhibitory neurons follow different connectivity rules.

Science.gov (United States)

Kwon, Osung; Feng, Linqing; Druckmann, Shaul; Kim, Jinhyun

2018-05-04

Neural circuits, governed by a complex interplay between excitatory and inhibitory neurons, are the substrate for information processing, and the organization of synaptic connectivity in neural network is an important determinant of circuit function. Here, we analyzed the fine structure of connectivity in hippocampal CA1 excitatory and inhibitory neurons innervated by Schaffer collaterals (SCs) using mGRASP in male mice. Our previous study revealed spatially structured synaptic connectivity between CA3-CA1 pyramidal cells (PCs). Surprisingly, parvalbumin-positive interneurons (PVs) showed a significantly more random pattern spatial structure. Notably, application of Peters' Rule for synapse prediction by random overlap between axons and dendrites enhanced structured connectivity in PCs, but, by contrast, made the connectivity pattern in PVs more random. In addition, PCs in a deep sublayer of striatum pyramidale appeared more highly structured than PCs in superficial layers, and little or no sublayer specificity was found in PVs. Our results show that CA1 excitatory PCs and inhibitory PVs innervated by the same SC inputs follow different connectivity rules. The different organizations of fine scale structured connectivity in hippocampal excitatory and inhibitory neurons provide important insights into the development and functions of neural networks. SIGNIFICANCE STATEMENT Understanding how neural circuits generate behavior is one of the central goals of neuroscience. An important component of this endeavor is the mapping of fine-scale connection patterns that underlie, and help us infer, signal processing in the brain. Here, using our recently developed synapse detection technology (mGRASP and neuTube), we provide detailed profiles of synaptic connectivity in excitatory (CA1 pyramidal) and inhibitory (CA1 parvalbumin-positive) neurons innervated by the same presynaptic inputs (CA3 Schaffer collaterals). Our results reveal that these two types of CA1 neurons follow

Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse

DEFF Research Database (Denmark)

Caldeira, Vanessa; Dougherty, Kimberly J.; Borgius, Lotta

2017-01-01

Rhythm generating neurons are thought to be ipsilaterally-projecting excitatory neurons in the thoracolumbar mammalian spinal cord. Recently, a subset of Shox2 interneurons (Shox2 non-V2a INs) was found to fulfill these criteria and make up a fraction of the rhythm-generating population. Here we...... than in cords from controls. Collectively, our findings indicate that excitatory Hb9::Cre-derived INs constitute a distinct population of neurons that participates in the rhythm generating kernel for spinal locomotion....... use Hb9::Cre mice to genetically manipulate Hb9::Cre-derived excitatory interneurons (INs) in order to determine the role of these INs in rhythm generation. We demonstrate that this line captures a consistent population of spinal INs which is mixed with respect to neurotransmitter phenotype...

The Evolution of the Type Ia Supernova Luminosity Function

NARCIS (Netherlands)

Shen, K.J.; Toonen, S.; Graur, O.

2017-01-01

Type Ia supernovae (SNe Ia) exhibit a wide diversity of peak luminosities and light curve shapes: the faintest SNe Ia are 10 times less luminous and evolve more rapidly than the brightest SNe Ia. Their differing characteristics also extend to their stellar age distributions, with fainter SNe Ia

Progenitor's Signatures in Type Ia Supernova Remnants

NARCIS (Netherlands)

Chiotellis, A.; Kosenko, D.; Schure, K.M.; Vink, J.

2013-01-01

The remnants of Type Ia supernovae (SNe Ia) can provide important clues about their progenitor histories. We discuss two well-observed supernova remnants (SNRs) that are believed to have resulted from SNe Ia, and use various tools to shed light on the possible progenitor histories. We find that

Mass-accreting white dwarfs and type Ia supernovae

Science.gov (United States)

Wang, Bo

2018-05-01

Type Ia supernovae (SNe Ia) play a prominent role in understanding the evolution of the Universe. They are thought to be thermonuclear explosions of mass-accreting carbon-oxygen white dwarfs (CO WDs) in binaries, although the mass donors of the accreting WDs are still not well determined. In this article, I review recent studies on mass-accreting WDs, including H- and He-accreting WDs. I also review currently most studied progenitor models of SNe Ia, i.e., the single-degenerate model (including the WD+MS channel, the WD+RG channel and the WD+He star channel), the double-degenerate model (including the violent merger scenario) and the sub-Chandrasekhar mass model. Recent progress on these progenitor models is discussed, including the initial parameter space for producing SNe Ia, the binary evolutionary paths to SNe Ia, the progenitor candidates for SNe Ia, the possible surviving companion stars of SNe Ia, some observational constraints, etc. Some other potential progenitor models of SNe Ia are also summarized, including the hybrid CONe WD model, the core-degenerate model, the double WD collision model, the spin-up/spin-down model and the model of WDs near black holes. To date, it seems that two or more progenitor models are needed to explain the observed diversity among SNe Ia.

The optimal protocol to reduce blood loss and blood transfusion after unilateral total knee replacement: Low-dose IA-TXA plus 30-min drain clamping versus drainage clamping for the first 3 h without IA-TXA.

Science.gov (United States)

Park, Joo Hyun; Choi, Sung Wook; Shin, Eun Ho; Park, Myung Hoon; Kim, Myung Ku

2017-01-01

Although intraarticular tranexamic acid (IA-TXA) administration or drainage clamping are popular methods used to reduce blood loss after total knee replacement (TKR), the protocol remains controversial. We aimed (1) to establish new protocols through investigating whether two methods, that is, low-dose (500 mg) IA-TXA plus 30-min drain clamping and drainage clamping for the first 3 h without IA-TXA, can reduce blood loss and blood transfusion after unilateral TKR and (2) to make recommendations related to clinical application. This study, conducted from September 2014 to June 2016 related to enrolled 95 patients with primary osteoarthritis who were to have a unilateral cemented TKR, was nonrandomized and retrospective. In group A, the drain was released following tourniquet deflation. In group B, 500-mg TXA was injected into the knee joint via a drain tube after fascia closure and the drain was clamped for the first 30 min to prevent leakage. In group C, the drain was clamped for the first 3-h postoperation. Demographic characteristics and clinical data were collected, including the levels of hematocrit (Hct), the total blood loss (TBL), drained blood volume (BV), the amount of blood transfused, and any complications that developed. We found a significantly lower postoperative TBL, drained BV, decreasing Hct level, and less transfused BV in the IA-TXA injection group (group B) and the 3-h drainage clamping group (group C) compared to the conventional negative drainage group (group A; p optimal than drainage clamping in patients with high bleeding tendency or lateral retinacular release during TKR, who would be concerned about postoperative wound complication.

Cloud Infrastructure & Applications - CloudIA

Science.gov (United States)

Sulistio, Anthony; Reich, Christoph; Doelitzscher, Frank

The idea behind Cloud Computing is to deliver Infrastructure-as-a-Services and Software-as-a-Service over the Internet on an easy pay-per-use business model. To harness the potentials of Cloud Computing for e-Learning and research purposes, and to small- and medium-sized enterprises, the Hochschule Furtwangen University establishes a new project, called Cloud Infrastructure & Applications (CloudIA). The CloudIA project is a market-oriented cloud infrastructure that leverages different virtualization technologies, by supporting Service-Level Agreements for various service offerings. This paper describes the CloudIA project in details and mentions our early experiences in building a private cloud using an existing infrastructure.

Identification of EhTIF-IA: The putative E. histolytica orthologue of the human ribosomal RNA transcription initiation factor-IA.

Science.gov (United States)

Srivastava, Ankita; Bhattacharya, Alok; Bhattacharya, Sudha; Jhingan, Gagan Deep

2016-03-01

Initiation of rDNA transcription requires the assembly of a specific multi-protein complex at the rDNA promoter containing the RNA Pol I with auxiliary factors. One of these factors is known as Rrn3P in yeast and Transcription Initiation Factor IA (TIF-IA) in mammals. Rrn3p/TIF-IA serves as a bridge between RNA Pol I and the pre-initiation complex at the promoter. It is phosphorylated at multiple sites and is involved in regulation of rDNA transcription in a growth-dependent manner. In the early branching parasitic protist Entamoeba histolytica, the rRNA genes are present exclusively on circular extra chromosomal plasmids. The protein factors involved in regulation of rDNA transcription in E. histolytica are not known. We have identified the E. histolytica equivalent of TIF-1A (EhTIF-IA) by homology search within the database and was further cloned and expressed. Immuno-localization studies showed that EhTIF-IA co-localized partially with fibrillarin in the peripherally localized nucleolus. EhTIF-IA was shown to interact with the RNA Pol I-specific subunit RPA12 both in vivo and in vitro. Mass spectroscopy data identified RNA Pol I-specific subunits and other nucleolar proteins to be the interacting partners of EhTIF-IA. Our study demonstrates for the first time a conserved putative RNA Pol I transcription factor TIF-IA in E. histolytica.

Genetics Home Reference: hereditary sensory neuropathy type IA

Science.gov (United States)

... sensory neuropathy type IA Hereditary sensory neuropathy type IA Printable PDF Open All Close All Enable Javascript ... expand/collapse boxes. Description Hereditary sensory neuropathy type IA is a condition characterized by nerve abnormalities in ...

Evidence for an excitatory amino acid pathway in the brainstem and for its involvement in cardiovascular control.

Science.gov (United States)

Somogyi, P; Minson, J B; Morilak, D; Llewellyn-Smith, I; McIlhinney, J R; Chalmers, J

1989-09-04

The source and possible role of excitatory amino acid projections to areas of the ventrolateral medulla (VLM) involved in cardiovascular control were studied. Following the injection of [3H]D-aspartate ([3H]D-Asp), a selective tracer for excitatory amino acid pathways, into vasopressor or vasodepressor areas of the VLM in rats, more than 90% of retrogradely labelled neurones were found in the nucleus of the solitary tract (NTS). Very few of the [3H]D-Asp-labelled cells were immunoreactive for tyrosine hydroxylase, none for phenylethanolamine-N-methyltransferase or gamma-aminobutyric acid. The density of labelled cells in the NTS was similar to that obtained with the non-selective tracers wheat germ agglutinin-horseradish peroxidase (WGA-HRP) and WGA-colloidal gold, but these tracers also labelled other cell groups in the medulla. Furthermore, the decrease in blood pressure, caused by pharmacological activation of neurones in the NTS of rats, or by electrical stimulation of the aortic depressor nerve in rabbits could be blocked by the selective N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate injected into the caudal vasodepressor area of the VLM. This area corresponds to the termination of [3H]D-Asp transporting NTS neurones. These results provide evidence that a population of NTS neurones projecting to the VLM use excitatory amino acids as transmitters. Among other possible functions, this pathway may mediate tonic and reflex control of blood pressure via NMDA receptors in the VLM.

THE SPECTROSCOPIC DIVERSITY OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Blondin, S.; Matheson, T.; Kirshner, R. P.; Mandel, K. S.; Challis, P.; Berlind, P.; Calkins, M.; Garnavich, P. M.; Jha, S. W.; Modjaz, M.; Riess, A. G.; Schmidt, B. P.

2012-01-01

We present 2603 spectra of 462 nearby Type Ia supernovae (SNe Ia), including 2065 previously unpublished spectra, obtained during 1993-2008 through the Center for Astrophysics Supernova Program. There are on average eight spectra for each of the 313 SNe Ia with at least two spectra. Most of the spectra were obtained with the FAST spectrograph at the Fred Lawrence Whipple Observatory 1.5 m telescope and reduced in a consistent manner, making this data set well suited for studies of SN Ia spectroscopic diversity. Using additional data from the literature, we study the spectroscopic and photometric properties of SNe Ia as a function of spectroscopic class using the classification schemes of Branch et al. and Wang et al. The width-luminosity relation appears to be steeper for SNe Ia with broader lines, although the result is not statistically significant with the present sample. Based on the evolution of the characteristic Si II λ6355 line, we propose improved methods for measuring velocity gradients, revealing a larger range than previously suspected, from ∼0 to ∼400 km s −1 day −1 considering the instantaneous velocity decline rate at maximum light. We find a weaker and less significant correlation between Si II velocity and intrinsic B – V color at maximum light than reported by Foley et al., owing to a more comprehensive treatment of uncertainties and host galaxy dust. We study the extent of nuclear burning and the presence of unburnt carbon in the outermost layers of the ejecta and report new detections of C II λ6580 in 23 early-time SN Ia spectra. The frequency of C II detections is not higher in SNe Ia with bluer colors or narrower light curves, in conflict with the recent results of Thomas et al. Based on nebular spectra of 27 SNe Ia, we find no relation between the FWHM of the iron emission feature at ∼4700 Å and Δm 15 (B) after removing the two low-luminosity SN 1986G and SN 1991bg, suggesting that the peak luminosity is not strongly dependent

Clinical outcome and imaging changes after intraarticular (IA) application of etanercept or methylprednisolone in rheumatoid arthritis: Magnetic resonance imaging and ultrasound-Doppler show no effect of IA injections in the wrist after 4 weeks

DEFF Research Database (Denmark)

Boesen, M.; Boesen, L.; Jensen, K.E.

2008-01-01

Objective. To assess the magnetic resonance imaging (MRI) and ultrasound (US) changes in the wrist of patients with rheumatoid arthritis (RA) 4 weeks after an US guided intraarticular (IA) injection. Methods. Contrast enhanced MRI and US-Doppler were performed at baseline and 4 weeks after IA....... Conclusion. In contrast to the clinical evaluation, imaging measures of relevance for the estimation of inflammation, US-Doppler, US RI, MRI synovitis, and bone-marrow edema did not change 4 weeks after a single IA injection of either methylprednisolone or etanercept in the wrist. Within the same period...... target joint score (p 4 weeks. Baseline MRI synovitis score was mean 5.08 (range 3-9) and was unchanged at followup in the whole group (p = 0.52) and between treatment groups (p = 0.43). MRI edema score (mean 4.46, range 0...

Excitatory and inhibitory synaptic mechanisms at the first stage of integration in the electroreception system of the shark

DEFF Research Database (Denmark)

Rotem, Naama; Sestieri, Emanuel; Hounsgaard, Jørn Dybkjær

2014-01-01

High impulse rate in afferent nerves is a common feature in many sensory systems that serve to accommodate a wide dynamic range. However, the first stage of integration should be endowed with specific properties that enable efficient handling of the incoming information. In elasmobranches...... of this afferent pathway. We found that stimulating the afferent nerve activates a mixture of excitatory and inhibitory synapses mediated by AMPA-like and GABAA receptors, respectively. The excitatory synapses that are extremely efficient in activating the postsynaptic neurons display unusual voltage dependence......, enabling them to operate as a current source. The inhibitory input is powerful enough to completely eliminate the excitatory action of the afferent nerve but is ineffective regarding other excitatory inputs. These observations can be explained by the location and efficiency of the synapses. We conclude...

Why do pathological stage IA lung adenocarcinomas vary from prognosis?: a clinicopathologic study of 176 patients with pathological stage IA lung adenocarcinoma based on the IASLC/ATS/ERS classification.

Science.gov (United States)

Zhang, Jie; Wu, Jie; Tan, Qiang; Zhu, Lei; Gao, Wen

2013-09-01

Patients with pathological stage IA adenocarcinoma (AC) have a variable prognosis, even if treated in the same way. The postoperative treatment of pathological stage IA patients is also controversial. We identified 176 patients with pathological stage IA AC who had undergone a lobectomy and mediastinal lymph node dissection at the Shanghai Chest Hospital, Shanghai, China, between 2000 and 2006. No patient had preoperative treatment. The histologic subtypes of all patients were classified according to the 2011 International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) international multidisciplinary lung AC classification. Patients' 5-year overall survival (OS) and 5-year disease-free survival (DFS) were calculated using Kaplan-Meier and Cox regression analyses. One hundred seventy-six patients with pathological stage IA AC had an 86.6% 5-year OS and 74.6% 5-year DFS. The 10 patients with micropapillary predominant subtype had the lowest 5-year DFS (40.0%).The 12 patients with solid predominant with mucin production subtype had the lowest 5-year OS (66.7%). Univariate and multivariate analysis showed that sex and prognositic groups of the IASLC/ATS/ERS histologic classification were significantly associated with 5-year DFS of pathological stage IA AC. Our study revealed that sex was an independent prognostic factor of pathological stage IA AC. The IASLC/ATS/ERS classification of lung AC identifies histologic categories with prognostic differences that could be helpful in clinical therapy.

Frequency of islet cell autoantibodies (IA-2 and GAD in young Brazilian type 1 diabetes patients

Directory of Open Access Journals (Sweden)

Pardini V.C.

1999-01-01

Full Text Available Type 1 diabetes, as an autoimmune disease, presents several islet cell-specific autoantibodies such as islet cell antibody (ICA, anti-insulin, anti-glutamic acid decarboxylase (GAD and the antibody (Ab against tyrosine phosphatase (PTP-like protein known as ICA-512 (IA-2. In order to determine the frequency of the anti-GAD and anti-IA-2 autoantibodies in Brazilian type 1 diabetes patients we studied 35 diabetes mellitus (DM type 1 patients with recent-onset disease (£12 months and 37 type 1 diabetes patients with long-duration diabetes (>12 months who were compared to 12 children with normal fasting glucose. Anti-GAD65 and anti-IA-2 autoantibodies were detected with commercial immunoprecipitation assays. The frequency of positive results in recent-onset DM type 1 patients was 80.0% for GADAb, 62.9% for IA-2Ab and 82.9% for GADAb and/or IA-2Ab. The long-duration type 1 diabetes subjects presented frequencies of 54.1% for GADAb and IA-2Ab, and 67.5% for GAD and/or IA-2 antibodies. The control group showed no positive cases. Anti-GAD and IA-2 assays showed a high frequency of positivity in these Brazilian type 1 diabetes patients, who presented the same prevalence as a Caucasian population.

Bistability Analysis of Excitatory-Inhibitory Neural Networks in Limited-Sustained-Activity Regime

International Nuclear Information System (INIS)

Ni Yun; Wu Liang; Wu Dan; Zhu Shiqun

2011-01-01

Bistable behavior of neuronal complex networks is investigated in the limited-sustained-activity regime when the network is composed of excitatory and inhibitory neurons. The standard stability analysis is performed on the two metastable states separately. Both theoretical analysis and numerical simulations show consistently that the difference between time scales of excitatory and inhibitory populations can influence the dynamical behaviors of the neuronal networks dramatically, leading to the transition from bistable behaviors with memory effects to the collapse of bistable behaviors. These results may suggest one possible neuronal information processing by only tuning time scales. (interdisciplinary physics and related areas of science and technology)

LINKING TYPE Ia SUPERNOVA PROGENITORS AND THEIR RESULTING EXPLOSIONS

International Nuclear Information System (INIS)

Foley, Ryan J.; Kirshner, Robert P.; Simon, Joshua D.; Burns, Christopher R.; Gal-Yam, Avishay; Hamuy, Mario; Morrell, Nidia I.; Phillips, Mark M.; Shields, Gregory A.; Sternberg, Assaf

2012-01-01

Comparing the ejecta velocities at maximum brightness and narrow circumstellar/interstellar Na D absorption line profiles of a sample of 23 Type Ia supernovae (SNe Ia), we determine that the properties of SN Ia progenitor systems and explosions are intimately connected. As demonstrated by Sternberg et al., half of all SNe Ia with detectable Na D absorption at the host-galaxy redshift in high-resolution spectroscopy have Na D line profiles with significant blueshifted absorption relative to the strongest absorption component, which indicates that a large fraction of SN Ia progenitor systems have strong outflows. In this study, we find that SNe Ia with blueshifted circumstellar/interstellar absorption systematically have higher ejecta velocities and redder colors at maximum brightness relative to the rest of the SN Ia population. This result is robust at a 98.9%-99.8% confidence level, providing the first link between the progenitor systems and properties of the explosion. This finding is further evidence that the outflow scenario is the correct interpretation of the blueshifted Na D absorption, adding additional confirmation that some SNe Ia are produced from a single-degenerate progenitor channel. An additional implication is that either SN Ia progenitor systems have highly asymmetric outflows that are also aligned with the SN explosion or SNe Ia come from a variety of progenitor systems where SNe Ia from systems with strong outflows tend to have more kinetic energy per unit mass than those from systems with weak or no outflows.

Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn.

Science.gov (United States)

Gutierrez-Mecinas, Maria; Watanabe, Masahiko; Todd, Andrew J

2014-12-11

Gastrin-releasing peptide (GRP) and its receptor have been shown to play an important role in the sensation of itch. However, although GRP immunoreactivity has been detected in the spinal dorsal horn, there is debate about whether this originates from primary afferents or local excitatory interneurons. We therefore examined the relation of GRP immunoreactivity to that seen with antibodies that label primary afferent or excitatory interneuron terminals. We tested the specificity of the GRP antibody by preincubating with peptides with which it could potentially cross-react. We also examined tissue from a mouse line in which enhanced green fluorescent protein (EGFP) is expressed under control of the GRP promoter. GRP immunoreactivity was seen in both primary afferent and non-primary glutamatergic axon terminals in the superficial dorsal horn. However, immunostaining was blocked by pre-incubation of the antibody with substance P, which is present at high levels in many nociceptive primary afferents. EGFP+ cells in the GRP-EGFP mouse did not express Pax2, and their axons contained the vesicular glutamate transporter 2 (VGLUT2), indicating that they are excitatory interneurons. In most cases, their axons were also GRP-immunoreactive. Multiple-labelling immunocytochemical studies indicated that these cells did not express either of the preprotachykinin peptides, and that they generally lacked protein kinase Cγ, which is expressed by a subset of the excitatory interneurons in this region. These results show that GRP is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway. They also suggest that the GRP immunoreactivity seen in primary afferents in previous studies may have resulted from cross-reaction of the GRP antibody with substance P or the closely related peptide neurokinin A.

Clues on Type Ia Supernovae Progenitors

International Nuclear Information System (INIS)

Piersanti, Luciano; Tornambe, Amedeo

2005-01-01

We show that in the framework of canonical stellar evolution it is hard, if not impossible, to determine the growth in mass of a CO White Dwarf, up to the Chandrasekhar limit by means of mass transfer from its companion in a binary system. This is the case either if matter is accreted from a normal companion with an H-rich envelope or if direct CO accretion occurs from a CO WD companion. At variance, we show that if the effects of rotation are taken into account in modeling the accretion process, a CO WD can increase its mass at the expenses of the degenerate CO companion up and beyond 1.4 M· , so that an explosive event of the type Ia class is naturally produced. This theoretical finding revives the Double Degenerate scenario for type Ia SNe progenitors. In such a case the internal spread in the observational properties of type Ia SNe may be interpreted as a consequence of different total masses; hence differences between SNe Ia in nearby elliptical galaxies and the majority of those in spirals should be expected and the current use of type Ia SNe as cosmological distance indicators should be justified

EVOLVING TO TYPE Ia SUPERNOVAE WITH SHORT DELAY TIMES

International Nuclear Information System (INIS)

Wang Bo; Chen Xuefei; Han Zhanwen; Meng Xiangcun

2009-01-01

The single-degenerate model is currently a favorable progenitor model for Type Ia supernovae (SNe Ia). Recent investigations on the white dwarf (WD) + He star channel of the single-degenerate model imply that this channel is noteworthy for producing SNe Ia. In this paper, we studied SN Ia birthrates and delay times of this channel via a detailed binary population synthesis approach. We found that the Galactic SN Ia birthrate from the WD + He star channel is ∼0.3 x 10 -3 yr -1 according to our standard model, and that this channel can explain SNe Ia with short delay times (∼4.5 x 10 7 -1.4 x 10 8 yr). Meanwhile, these WD + He star systems may be related to the young supersoft X-ray sources prior to SN Ia explosions.

New approaches for modeling type Ia supernovae

International Nuclear Information System (INIS)

Zingale, Michael; Almgren, Ann S.; Bell, John B.; Day, Marcus S.; Rendleman, Charles A.; Woosley, Stan

2007-01-01

Type Ia supernovae (SNe Ia) are the largest thermonuclear explosions in the Universe. Their light output can be seen across great distances and has led to the discovery that the expansion rate of the Universe is accelerating. Despite the significance of SNe Ia, there are still a large number of uncertainties in current theoretical models. Computational modeling offers the promise to help answer the outstanding questions. However, even with today's supercomputers, such calculations are extremely challenging because of the wide range of length and timescales. In this paper, we discuss several new algorithms for simulations of SNe Ia and demonstrate some of their successes

Instrument ampersand controls section (IA) improvements

International Nuclear Information System (INIS)

Kramer, C.; Paul, J.

1993-01-01

This portion of the panel session briefly delineates improvements in the Instrument and Controls (IA) Section over the past few years. These improvements are listed briefly in summary form. The status of publication of the IA Section of AG-1 is reviewed

Type Ia Supernovae: Energetics, Neutronization and Nucleosynthesis

International Nuclear Information System (INIS)

Truran, James W.; Calder, Alan C.; Townsley, Dean M.; Seitenzahl, Ivo R.; Peng, Fang; Vladimirova, Natalia; Lamb, Donald Q.; Brown, Edward F.

2007-01-01

The utility of Type Ia supernovae, not simply as probes of the distance scale but also as a means of constraining the properties of dark energy, demands a significant improvement in theoretical predictions of their properties in outburst. To this end, we have given substantial effort to quantifying the energetics and nucleosynthesis properties of deflagration fronts in the interiors of the putative carbon-oxygen white dwarf progenitors of Type Ia thermonuclear supernovae. We briefly review some essential features of our flame model and its properties in this paper and discuss its implications both for our multidimensional numerical simulations of SNe Ia and for nucleosynthesis (specifically 56Ni production) in SNe Ia and Galactic chemical evolution

Loss of MeCP2 From Forebrain Excitatory Neurons Leads to Cortical Hyperexcitation and Seizures

Science.gov (United States)

Zhang, Wen; Peterson, Matthew; Beyer, Barbara; Frankel, Wayne N.

2014-01-01

Mutations of MECP2 cause Rett syndrome (RTT), a neurodevelopmental disorder leading to loss of motor and cognitive functions, impaired social interactions, and seizure at young ages. Defects of neuronal circuit development and function are thought to be responsible for the symptoms of RTT. The majority of RTT patients show recurrent seizures, indicating that neuronal hyperexcitation is a common feature of RTT. However, mechanisms underlying hyperexcitation in RTT are poorly understood. Here we show that deletion of Mecp2 from cortical excitatory neurons but not forebrain inhibitory neurons in the mouse leads to spontaneous seizures. Selective deletion of Mecp2 from excitatory but not inhibitory neurons in the forebrain reduces GABAergic transmission in layer 5 pyramidal neurons in the prefrontal and somatosensory cortices. Loss of MeCP2 from cortical excitatory neurons reduces the number of GABAergic synapses in the cortex, and enhances the excitability of layer 5 pyramidal neurons. Using single-cell deletion of Mecp2 in layer 2/3 pyramidal neurons, we show that GABAergic transmission is reduced in neurons without MeCP2, but is normal in neighboring neurons with MeCP2. Together, these results suggest that MeCP2 in cortical excitatory neurons plays a critical role in the regulation of GABAergic transmission and cortical excitability. PMID:24523563

HOW TO FIND GRAVITATIONALLY LENSED TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Goldstein, Daniel A.; Nugent, Peter E.

2017-01-01

Type Ia supernovae (SNe Ia) that are multiply imaged by gravitational lensing can extend the SN Ia Hubble diagram to very high redshifts ( z ≳ 2), probe potential SN Ia evolution, and deliver high-precision constraints on H _0, w , and Ω_m via time delays. However, only one, iPTF16geu, has been found to date, and many more are needed to achieve these goals. To increase the multiply imaged SN Ia discovery rate, we present a simple algorithm for identifying gravitationally lensed SN Ia candidates in cadenced, wide-field optical imaging surveys. The technique is to look for supernovae that appear to be hosted by elliptical galaxies, but that have absolute magnitudes implied by the apparent hosts’ photometric redshifts that are far brighter than the absolute magnitudes of normal SNe Ia (the brightest type of supernovae found in elliptical galaxies). Importantly, this purely photometric method does not require the ability to resolve the lensed images for discovery. Active galactic nuclei, the primary sources of contamination that affect the method, can be controlled using catalog cross-matches and color cuts. Highly magnified core-collapse SNe will also be discovered as a byproduct of the method. Using a Monte Carlo simulation, we forecast that the Large Synoptic Survey Telescope can discover up to 500 multiply imaged SNe Ia using this technique in a 10 year z -band search, more than an order of magnitude improvement over previous estimates. We also predict that the Zwicky Transient Facility should find up to 10 multiply imaged SNe Ia using this technique in a 3 year R -band search—despite the fact that this survey will not resolve a single system.

A Model for Forecasting Enlisted Student IA Billet Requirements

Science.gov (United States)

2016-03-01

IA execution ........................................... 4   Figure 2.   Learning center to resource sponsor alignment...initial entry training” [3]. 4 Figure 1. Training that counts as student IA execution The second type of chargeable training is the...Reference [ 4 ] describes the process the Navy uses to build the student IA program. It comprises three steps. The first is to forecast student IA E

Intelligent Autonomous Systems 11: IAS-11

NARCIS (Netherlands)

Christensen, H.I.; Groen, F.; Petriu, E.

2010-01-01

This volume contains the proceedings of the eleventh International Conference on Intelligent Autonomous Systems (IAS-11) at the University of Ottawa in Canada. As ever, the purpose of the IAS conference is to bring together leading international researchers with an interest in all aspects of the

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

Science.gov (United States)

Krashes, Michael J; Shah, Bhavik P; Madara, Joseph C; Olson, David P; Strochlic, David E; Garfield, Alastair S; Vong, Linh; Pei, Hongjuan; Watabe-Uchida, Mitsuko; Uchida, Naoshige; Liberles, Stephen D; Lowell, Bradford B

2014-03-13

Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently induce intense hunger and subsequent food intake. Consistent with their obligatory role in regulating appetite, genetic ablation or chemogenetic inhibition of AgRP neurons decreases feeding. Excitatory input to AgRP neurons is important in caloric-deficiency-induced activation, and is notable for its remarkable degree of caloric-state-dependent synaptic plasticity. Despite the important role of excitatory input, its source(s) has been unknown. Here, through the use of Cre-recombinase-enabled, cell-specific neuron mapping techniques in mice, we have discovered strong excitatory drive that, unexpectedly, emanates from the hypothalamic paraventricular nucleus, specifically from subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1). Chemogenetic stimulation of these afferent neurons in sated mice markedly activates AgRP neurons and induces intense feeding. Conversely, acute inhibition in mice with caloric-deficiency-induced hunger decreases feeding. Discovery of these afferent neurons capable of triggering hunger advances understanding of how this intense motivational state is regulated.

Search for surviving companions in type Ia supernova remnants

International Nuclear Information System (INIS)

Pan, Kuo-Chuan; Ricker, Paul M.; Taam, Ronald E.

2014-01-01

The nature of the progenitor systems of type Ia supernovae (SNe Ia) is still unclear. One way to distinguish between the single-degenerate scenario and double-degenerate scenario for their progenitors is to search for the surviving companions (SCs). Using a technique that couples the results from multi-dimensional hydrodynamics simulations with calculations of the structure and evolution of main-sequence- (MS-) and helium-rich SCs, the color and magnitude of MS- and helium-rich SCs are predicted as functions of time. The SC candidates in Galactic type Ia supernova remnants (Ia SNR) and nearby extragalactic Ia SNRs are discussed. We find that the maximum detectable distance of MS SCs (helium-rich SCs) is 0.6-4 Mpc (0.4-16 Mpc), if the apparent magnitude limit is 27 in the absence of extinction, suggesting that the Large and Small Magellanic Clouds and the Andromeda Galaxy are excellent environments in which to search for SCs. However, only five Ia SNRs have been searched for SCs, showing little support for the standard channels in the singe-degenerate scenario. To better understand the progenitors of SNe Ia, we encourage the search for SCs in other nearby Ia SNRs.

Two populations of progenitors for Type Ia supernovae?

Science.gov (United States)

Mannucci, F.; Della Valle, M.; Panagia, N.

2006-08-01

We use recent observations of the evolution of the Type Ia supernova (SN Ia) rate with redshift, the dependence of the SN Ia rate on the colours of the parent galaxies, and the enhancement of the SN Ia rate in radio-loud early-type galaxies to derive on robust empirical grounds, the delay time distribution (DTD) between the formation of the progenitor star and its explosion as an SN. Our analysis finds: (i) delay times as long as 3-4 Gyr, derived from observations of SNe Ia at high redshift, cannot reproduce the dependence of the SN Ia rate on the colours and on the radio-luminosity of the parent galaxies, as observed in the local Universe; (ii) the comparison between observed SN rates and a grid of theoretical `single-population' DTDs shows that only a few of them are possibly consistent with observations. The most successful models are all predicting a peak of SN explosions soon after star formation and an extended tail in the DTD, and can reproduce the data but only at a modest statistical confidence level; (iii) present data are best matched by a bimodal DTD, in which about 50 per cent of SNe Ia (dubbed `prompt' SNe Ia) explode soon after their stellar birth, in a time of the order of 108 yr, while the remaining 50 per cent (`tardy' SNe Ia) have a much wider distribution, well described by an exponential function with a decay time of about 3 Gyr. The presence in the DTD of both a strong peak at early times and a prolonged exponential tail, coupled with the well-established bimodal distribution of the decay rate (Δm15) and the systematic difference observed in the expansion velocities of the ejecta of SNe Ia in ellipticals and spirals, suggests the existence of two classes of progenitors. We discuss the cosmological implications of this result and make simple predictions, which are testable with future instrumentation.

MEASURING EJECTA VELOCITY IMPROVES TYPE Ia SUPERNOVA DISTANCES

International Nuclear Information System (INIS)

Foley, Ryan J.; Kasen, Daniel

2011-01-01

We use a sample of 121 spectroscopically normal Type Ia supernovae (SNe Ia) to show that their intrinsic color is correlated with their ejecta velocity, as measured from the blueshift of the Si II λ6355 feature near maximum brightness, v SiII . The SN Ia sample was originally used by Wang et al. to show that the relationship between color excess and peak magnitude, which in the absence of intrinsic color differences describes a reddening law, was different for two subsamples split by v SiII (defined as 'Normal' and 'High Velocity'). We verify this result, but find that the two subsamples have the same reddening law when extremely reddened events (E(B - V)>0.35 mag) are excluded. We also show that (1) the High-Velocity subsample is offset by ∼0.06 mag to the red from the Normal subsample in the (B max - V max )-M V plane, (2) the B max - V max cumulative distribution functions of the two subsamples have nearly identical shapes, but the High-Velocity subsample is offset by ∼0.07 mag to the red in B max - V max , and (3) the bluest High-Velocity SNe Ia are ∼0.10 mag redder than the bluest Normal SNe Ia. Together, this evidence indicates a difference in intrinsic color for the subsamples. Accounting for this intrinsic color difference reduces the scatter in Hubble residuals from 0.190 mag to 0.130 mag for SNe Ia with A V ∼ V found in large SN Ia samples. We explain the correlation between ejecta velocity and color as increased line blanketing in the High-Velocity SNe Ia, causing them to become redder. We discuss some implications of this result, and stress the importance of spectroscopy for future SN Ia cosmology surveys, with particular focus on the design of WFIRST.

HOW TO FIND GRAVITATIONALLY LENSED TYPE Ia SUPERNOVAE

Energy Technology Data Exchange (ETDEWEB)

Goldstein, Daniel A.; Nugent, Peter E. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States)

2017-01-01

Type Ia supernovae (SNe Ia) that are multiply imaged by gravitational lensing can extend the SN Ia Hubble diagram to very high redshifts ( z ≳ 2), probe potential SN Ia evolution, and deliver high-precision constraints on H {sub 0}, w , and Ω{sub m} via time delays. However, only one, iPTF16geu, has been found to date, and many more are needed to achieve these goals. To increase the multiply imaged SN Ia discovery rate, we present a simple algorithm for identifying gravitationally lensed SN Ia candidates in cadenced, wide-field optical imaging surveys. The technique is to look for supernovae that appear to be hosted by elliptical galaxies, but that have absolute magnitudes implied by the apparent hosts’ photometric redshifts that are far brighter than the absolute magnitudes of normal SNe Ia (the brightest type of supernovae found in elliptical galaxies). Importantly, this purely photometric method does not require the ability to resolve the lensed images for discovery. Active galactic nuclei, the primary sources of contamination that affect the method, can be controlled using catalog cross-matches and color cuts. Highly magnified core-collapse SNe will also be discovered as a byproduct of the method. Using a Monte Carlo simulation, we forecast that the Large Synoptic Survey Telescope can discover up to 500 multiply imaged SNe Ia using this technique in a 10 year z -band search, more than an order of magnitude improvement over previous estimates. We also predict that the Zwicky Transient Facility should find up to 10 multiply imaged SNe Ia using this technique in a 3 year R -band search—despite the fact that this survey will not resolve a single system.

The effect of STDP temporal kernel structure on the learning dynamics of single excitatory and inhibitory synapses.

Directory of Open Access Journals (Sweden)

Yotam Luz

Full Text Available Spike-Timing Dependent Plasticity (STDP is characterized by a wide range of temporal kernels. However, much of the theoretical work has focused on a specific kernel - the "temporally asymmetric Hebbian" learning rules. Previous studies linked excitatory STDP to positive feedback that can account for the emergence of response selectivity. Inhibitory plasticity was associated with negative feedback that can balance the excitatory and inhibitory inputs. Here we study the possible computational role of the temporal structure of the STDP. We represent the STDP as a superposition of two processes: potentiation and depression. This allows us to model a wide range of experimentally observed STDP kernels, from Hebbian to anti-Hebbian, by varying a single parameter. We investigate STDP dynamics of a single excitatory or inhibitory synapse in purely feed-forward architecture. We derive a mean-field-Fokker-Planck dynamics for the synaptic weight and analyze the effect of STDP structure on the fixed points of the mean field dynamics. We find a phase transition along the Hebbian to anti-Hebbian parameter from a phase that is characterized by a unimodal distribution of the synaptic weight, in which the STDP dynamics is governed by negative feedback, to a phase with positive feedback characterized by a bimodal distribution. The critical point of this transition depends on general properties of the STDP dynamics and not on the fine details. Namely, the dynamics is affected by the pre-post correlations only via a single number that quantifies its overlap with the STDP kernel. We find that by manipulating the STDP temporal kernel, negative feedback can be induced in excitatory synapses and positive feedback in inhibitory. Moreover, there is an exact symmetry between inhibitory and excitatory plasticity, i.e., for every STDP rule of inhibitory synapse there exists an STDP rule for excitatory synapse, such that their dynamics is identical.

Type Ia Supernova Light Curve Inference: Hierarchical Models for Nearby SN Ia in the Optical and Near Infrared

Science.gov (United States)

Mandel, Kaisey; Kirshner, R. P.; Narayan, G.; Wood-Vasey, W. M.; Friedman, A. S.; Hicken, M.

2010-01-01

I have constructed a comprehensive statistical model for Type Ia supernova light curves spanning optical through near infrared data simultaneously. The near infrared light curves are found to be excellent standard candles (sigma(MH) = 0.11 +/- 0.03 mag) that are less vulnerable to systematic error from dust extinction, a major confounding factor for cosmological studies. A hierarchical statistical framework incorporates coherently multiple sources of randomness and uncertainty, including photometric error, intrinsic supernova light curve variations and correlations, dust extinction and reddening, peculiar velocity dispersion and distances, for probabilistic inference with Type Ia SN light curves. Inferences are drawn from the full probability density over individual supernovae and the SN Ia and dust populations, conditioned on a dataset of SN Ia light curves and redshifts. To compute probabilistic inferences with hierarchical models, I have developed BayeSN, a Markov Chain Monte Carlo algorithm based on Gibbs sampling. This code explores and samples the global probability density of parameters describing individual supernovae and the population. I have applied this hierarchical model to optical and near infrared data of over 100 nearby Type Ia SN from PAIRITEL, the CfA3 sample, and the literature. Using this statistical model, I find that SN with optical and NIR data have a smaller residual scatter in the Hubble diagram than SN with only optical data. The continued study of Type Ia SN in the near infrared will be important for improving their utility as precise and accurate cosmological distance indicators.

Host galaxies of type ia supernovae from the nearby supernova factory

Science.gov (United States)

Childress, Michael Joseph

Type Ia Supernovae (SNe Ia) are excellent distance indicators, yet the full details of the underlying physical mechanism giving rise to these dramatic stellar deaths remain unclear. As large samples of cosmological SNe Ia continue to be collected, the scatter in brightnesses of these events is equally affected by systematic errors as statistical. Thus we need to understand the physics of SNe Ia better, and in particular we must know more about the progenitors of these SNe so that we can derive better estimates for their true intrinsic brightnesses. The host galaxies of SNe Ia provide important indirect clues as to the nature of SN Ia progenitors. In this Thesis we utilize the host galaxies of SNe Ia discovered by the Nearby Supernova Factory (SNfactory) to pursue several key investigations into the nature of SN Ia progenitors and their effects on SN Ia brightnesses. We first examine the host galaxy of SN 2007if, an important member of the subclass of SNe Ia whose extreme brightnesses indicate a progenitor that exceeded the canonical Chandrasekhar-mass value presumed for normal SNe Ia, and show that the host galaxy of this SN is composed of very young stars and has extremely low metallicity, providing important constraints on progenitor scenarios for this SN. We then utilize the full sample of SNfactory host galaxy masses (measured from photometry) and metallicities (derived from optical spectroscopy) to examine several global properties of SN Ia progenitors: (i) we show that SN Ia hosts show tight agreement with the normal galaxy mass-metallicity relation; (ii) comparing the observed distribution of SN Ia host galaxy masses to a theoretical model that couples galaxy physics to the SN Ia delay time distribution (DTD), we show the power of the SN Ia host mass distribution in constraining the SN Ia DTD; and (iii) we show that the lack of ultra-low metallicities in the SNfactory SN Ia host sample gives provisional support for the theorized low-metallicity inhibition of

Abundance Tomography of Type Ia Supernovae

International Nuclear Information System (INIS)

Stehle, M.; Mazzali, P.A.; Hillebrandt, W.

2005-01-01

An analysis of early time spectra of Type Ia Supernovae is presented. A new method to derive a detailed abundance distribution of the SN ejecta through comparison with synthetic spectra, called 'Abundance Tomography' is introduced and applied to the normal SN Ia 2002bo. Conclusions regarding the explosion mechanism are drawn

NEAR-ULTRAVIOLET PROPERTIES OF A LARGE SAMPLE OF TYPE Ia SUPERNOVAE AS OBSERVED WITH THE Swift UVOT

International Nuclear Information System (INIS)

Milne, Peter A.; Brown, Peter J.; Roming, Peter W. A.; Vanden Berk, Daniel; Holland, Stephen T.; Immler, Stefan; Bufano, Filomena; Gehrels, Neil; Filippenko, Alexei V.; Ganeshalingam, Mohan; Li Weidong; Stritzinger, Maximilian; Phillips, Mark M.; Hicken, Malcolm; Kirshner, Robert P.; Challis, Peter J.; Mazzali, Paolo; Schmidt, Brian P.

2010-01-01

We present ultraviolet (UV) and optical photometry of 26 Type Ia supernovae (SNe Ia) observed from 2005 March to 2008 March with the NASA Swift Ultraviolet and Optical Telescope (UVOT). The dataset consists of 2133 individual observations, making it by far the most complete study of the UV emission from SNe Ia to date. Grouping the SNe into three subclasses as derived from optical observations, we investigate the evolution of the colors of these SNe, finding a high degree of homogeneity within the normal subclass, but dramatic differences between that group and the subluminous and SN 2002cx-like groups. For the normal events, the redder UV filters on UVOT (u, uvw1) show more homogeneity than do the bluer UV filters (uvm2, uvw2). Searching for purely UV characteristics to determine existing optically based groupings, we find the peak width to be a poor discriminant, but we do see a variation in the time delay between peak emission and the late, flat phase of the light curves. The UV light curves peak a few days before the B band for most subclasses (as was previously reported by Jha et al.), although the SN 2002cx-like objects peak at a very early epoch in the UV. That group also features the bluest emission observed among SNe Ia. As the observational campaign is ongoing, we discuss the critical times to observe, as determined by this study, in order to maximize the scientific output of future observations.

The Connection between IAS/IFRS and Social Responsibility

Directory of Open Access Journals (Sweden)

Stefano AMELIO

2016-05-01

Full Text Available The aim of the paper is to evaluate the degree of social responsibility arising from the statement of comprehensive income prepared according to IAS/IFRS, to demonstrate whether the values obtained from prospects and from the calculation of the indicators are sufficient to analyze the Company's performance from the perspective of social responsibility and sustainable value or not. In order to achieve the objective of harmonization, the European Union adopted the IAS/IFRS developed by the International Accounting Standards Board (IASB. The research is divided into two sections and the approach used is mainly theoretical and qualitative. In the first part, the financial statements to be prepared according to IAS 1 and IAS 7 and, in particular, the so called statement of profit or loss and other comprehensive income for the period are analyzed by underling the function of the same and by presenting some financial performance indicators. Then, the research highlights how these values obtained are not useful to communicate the company's strategy in terms of social responsibility and sustainable value. In the second part the analyses exposes the concept of social balance. According to the social responsibility view the IAS/IFRS financial statements should be accompanied by the social balance. It becomes crucial to complete the set of financial statements stated from IAS 1 with a social balance as well as the same IAS 1 contemplates. For this reason it is possible to say that the connection between IAS/IFRS and social responsibility is weak.

Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures

Science.gov (United States)

Koizumi, Schuichi; Fujishita, Kayoko; Tsuda, Makoto; Shigemoto-Mogami, Yukari; Inoue, Kazuhide

2003-09-01

Originally ascribed passive roles in the CNS, astrocytes are now known to have an active role in the regulation of synaptic transmission. Neuronal activity can evoke Ca2+ transients in astrocytes, and Ca2+ transients in astrocytes can evoke changes in neuronal activity. The excitatory neurotransmitter glutamate has been shown to mediate such bidirectional communication between astrocytes and neurons. We demonstrate here that ATP, a primary mediator of intercellular Ca2+ signaling among astrocytes, also mediates intercellular signaling between astrocytes and neurons in hippocampal cultures. Mechanical stimulation of astrocytes evoked Ca2+ waves mediated by the release of ATP and the activation of P2 receptors. Mechanically evoked Ca2+ waves led to decreased excitatory glutamatergic synaptic transmission in an ATP-dependent manner. Exogenous application of ATP does not affect postsynaptic glutamatergic responses but decreased presynaptic exocytotic events. Finally, we show that astrocytes exhibit spontaneous Ca2+ waves mediated by extracellular ATP and that inhibition of these Ca2+ responses enhanced excitatory glutamatergic transmission. We therefore conclude that ATP released from astrocytes exerts tonic and activity-dependent down-regulation of synaptic transmission via presynaptic mechanisms.

Dynamic excitatory and inhibitory gain modulation can produce flexible, robust and optimal decision-making.

Directory of Open Access Journals (Sweden)

Ritwik K Niyogi

Full Text Available Behavioural and neurophysiological studies in primates have increasingly shown the involvement of urgency signals during the temporal integration of sensory evidence in perceptual decision-making. Neuronal correlates of such signals have been found in the parietal cortex, and in separate studies, demonstrated attention-induced gain modulation of both excitatory and inhibitory neurons. Although previous computational models of decision-making have incorporated gain modulation, their abstract forms do not permit an understanding of the contribution of inhibitory gain modulation. Thus, the effects of co-modulating both excitatory and inhibitory neuronal gains on decision-making dynamics and behavioural performance remain unclear. In this work, we incorporate time-dependent co-modulation of the gains of both excitatory and inhibitory neurons into our previous biologically based decision circuit model. We base our computational study in the context of two classic motion-discrimination tasks performed in animals. Our model shows that by simultaneously increasing the gains of both excitatory and inhibitory neurons, a variety of the observed dynamic neuronal firing activities can be replicated. In particular, the model can exhibit winner-take-all decision-making behaviour with higher firing rates and within a significantly more robust model parameter range. It also exhibits short-tailed reaction time distributions even when operating near a dynamical bifurcation point. The model further shows that neuronal gain modulation can compensate for weaker recurrent excitation in a decision neural circuit, and support decision formation and storage. Higher neuronal gain is also suggested in the more cognitively demanding reaction time than in the fixed delay version of the task. Using the exact temporal delays from the animal experiments, fast recruitment of gain co-modulation is shown to maximize reward rate, with a timescale that is surprisingly near the

SINGLE-DEGENERATE TYPE Ia SUPERNOVAE ARE PREFERENTIALLY OVERLUMINOUS

International Nuclear Information System (INIS)

Fisher, Robert; Jumper, Kevin

2015-01-01

Recent observational and theoretical progress has favored merging and helium-accreting sub-Chandrasekhar mass white dwarfs (WDs) in the double-degenerate and the double-detonation channels, respectively, as the most promising progenitors of normal Type Ia supernovae (SNe Ia). Thus the fate of rapidly accreting Chandrasekhar mass WDs in the single-degenerate channel remains more mysterious then ever. In this paper, we clarify the nature of ignition in Chandrasekhar-mass single-degenerate SNe Ia by analytically deriving the existence of a characteristic length scale which establishes a transition from central ignitions to buoyancy-driven ignitions. Using this criterion, combined with data from three-dimensional simulations of convection and ignition, we demonstrate that the overwhelming majority of ignition events within Chandrasekhar-mass WDs in the single-degenerate channel are buoyancy-driven, and consequently lack a vigorous deflagration phase. We thus infer that single-degenerate SNe Ia are generally expected to lead to overluminous 1991T-like SNe Ia events. We establish that the rates predicted from both the population of supersoft X-ray sources (SSSs) and binary population synthesis models of the single-degenerate channel are broadly consistent with the observed rates of overluminous SNe Ia, and suggest that the population of SSSs are the dominant stellar progenitors of SNe 1991T-like events. We further demonstrate that the single-degenerate channel contribution to the normal and failed 2002cx-like rates is not likely to exceed 1% of the total SNe Ia rate. We conclude with a range of observational tests of overluminous SNe Ia which will either support or strongly constrain the single-degenerate scenario

Reddened, Redshifted, or Intrinsically Red? Understanding Near-ultraviolet Colors of Type Ia Supernovae

Energy Technology Data Exchange (ETDEWEB)

Brown, Peter J.; Landez, Nancy J. [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Texas A. and M. University, Department of Physics and Astronomy, 4242 TAMU, College Station, TX 77843 (United States); Milne, Peter A. [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Stritzinger, Maximilian D., E-mail: pbrown@physics.tamu.edu [Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark)

2017-02-20

The intrinsic colors of Type Ia supernovae (SNe Ia) are important to understanding their use as cosmological standard candles. Understanding the effects of reddening and redshift on the observed colors are complicated and dependent on the intrinsic spectrum, the filter curves, and the wavelength dependence of reddening. We present ultraviolet and optical data of a growing sample of SNe Ia observed with the Ultraviolet/Optical Telescope on the Swift spacecraft and use this sample to re-examine the near-UV (NUV) colors of SNe Ia. We find that a small amount of reddening ( E ( B − V ) = 0.2 mag) could account for the difference between groups designated as NUV-blue and NUV-red, and a moderate amount of reddening ( E ( B − V ) = 0.5 mag) could account for the whole NUV-optical differences. The reddening scenario, however, is inconsistent with the mid-UV colors and color evolution. The effect of redshift alone only accounts for part of the variation. Using a spectral template of SN2011fe, we can forward model the effects of redshift and reddening and directly compare those with the observed colors. We find that some SNe are consistent with reddened versions of SN2011fe, but most SNe Ia are much redder in the uvw 1 − v color than SN2011fe reddened to the same b − v color. The absolute magnitudes show that two out of five NUV-blue SNe Ia are blue because their near-UV luminosity is high, and the other three are optically fainter. We also show that SN 2011fe is not a “normal” SN Ia in the UV, but has colors placing it at the blue extreme of our sample.

Parallel prefrontal pathways reach distinct excitatory and inhibitory systems in memory-related rhinal cortices.

Science.gov (United States)

Bunce, Jamie G; Zikopoulos, Basilis; Feinberg, Marcia; Barbas, Helen

2013-12-15

To investigate how prefrontal cortices impinge on medial temporal cortices we labeled pathways from the anterior cingulate cortex (ACC) and posterior orbitofrontal cortex (pOFC) in rhesus monkeys to compare their relationship with excitatory and inhibitory systems in rhinal cortices. The ACC pathway terminated mostly in areas 28 and 35 with a high proportion of large terminals, whereas the pOFC pathway terminated mostly through small terminals in area 36 and sparsely in areas 28 and 35. Both pathways terminated in all layers. Simultaneous labeling of pathways and distinct neurochemical classes of inhibitory neurons, followed by analyses of appositions of presynaptic and postsynaptic fluorescent signal, or synapses, showed overall predominant association with spines of putative excitatory neurons, but also significant interactions with presumed inhibitory neurons labeled for calretinin, calbindin, or parvalbumin. In the upper layers of areas 28 and 35 the ACC pathway was associated with dendrites of neurons labeled with calretinin, which are thought to disinhibit neighboring excitatory neurons, suggesting facilitated hippocampal access. In contrast, in area 36 pOFC axons were associated with dendrites of calbindin neurons, which are poised to reduce noise and enhance signal. In the deep layers, both pathways innervated mostly dendrites of parvalbumin neurons, which strongly inhibit neighboring excitatory neurons, suggesting gating of hippocampal output to other cortices. These findings suggest that the ACC, associated with attention and context, and the pOFC, associated with emotional valuation, have distinct contributions to memory in rhinal cortices, in processes that are disrupted in psychiatric diseases. Copyright © 2013 Wiley Periodicals, Inc.

Manganese in Dwarf Galaxies as a Probe of Type Ia Supernovae

Science.gov (United States)

De Los Reyes, Mithi; Kirby, Evan N.

2018-06-01

Despite the importance of thermonuclear or Type Ia supernovae (SNe) as standard candles in astrophysics, the physical mechanisms behind Type Ia SNe are still poorly constrained. Theoretically, the nucleosynthetic yields from Type Ia SNe can distinguish among different models of Type Ia explosions. For example, neutron-rich elements such as manganese (Mn) are sensitive probes of the physics of Type Ia SNe because their abundances are correlated to the density of the progenitor white dwarf. Since dwarf galaxies' chemical evolution is dominated by Type Ia SNe at late times, Type Ia nucleosynthetic yields can be indirectly inferred from stellar abundances in dwarf galaxies. However, previous measurements of Mn in dwarf galaxies are too incomplete to draw definitive conclusions on the Type Ia explosion mechanism. In this work, we therefore use medium-resolution stellar spectroscopy from Keck/DEIMOS to measure Mn abundances in red giants in several Milky Way satellite galaxies. We report average Type Ia Mn yields computed from these abundances, and we discuss the implications for Type Ia supernova physics.

Type-Ia Supernova Rates and the Progenitor Problem: A Review

Science.gov (United States)

Maoz, D.; Mannucci, F.

2012-01-01

The identity of the progenitor systems of type-Ia supernovae (SNe Ia) is a major unsolved problem in astrophysics. SN Ia rates are providing some striking clues. We review the basics of SN rate measurement, preach about some sins of SN rate measurement and analysis, and illustrate one of these sins with an analogy about Martian scientists. We review the recent progress in measuring SN Ia rates in various environments and redshifts, and their use to reconstruct the SN Ia delay-time distribution (DTD) - the SN rate versus time that would follow a hypothetical brief burst of star formation. A good number of DTD measurements, using a variety of methods, appear to be converging. At delays 1measurements show a similar, ~t-1, power-law shape. The DTD peaks at the shortest delays probed. This result supports the idea of a double-degenerate progenitor origin for SNe Ia. Single-degenerate progenitors may still play a role in producing short-delay SNe Ia, or perhaps all SNe Ia, if the red-giant donor channel is more efficient than is found by most theoretical models. The DTD normalization enjoys fairly good agreement (though perhaps some tension), among the various measurements, with a Hubble time-integrated DTD value of about 2+/-1 SNe Ia per 1000Msolar (stellar mass formed with a low-mass turnover initial mass function). The local WD binary population suggests that the WD merger rate can explain the Galactic SN Ia rate, but only if sub-Chandra mergers lead to SN Ia events. We point to some future directions that should lead to progress in the field, including measurement of the bivariate (delay and stretch) SN Ia response function.

Three-dimensional Modeling of Type Ia Supernova Explosions

Science.gov (United States)

Khokhlov, Alexei

2001-06-01

A deflagration explosion of a Type Ia Supernova (SNIa) is studied using three-dimensional, high-resolution, adaptive mesh refinement fluid dynamic calculations. Deflagration speed in an exploding Chandrasekhar-mass carbon-oxygen white dwarf (WD) grows exponentially, reaches approximately 30the speed of sound, and then declines due to a WD expansion. Outermost layers of the WD remain unburned. The explosion energy is comparable to that of a Type Ia supernova. The freezing of turbulent motions by expansion appears to be a crucial physical mechanism regulating the strength of a supernova explosion. In contrast to one-dimensional models, three-dimensional calculations predict the formation of Si-group elements and pockets of unburned CO in the middle and in central regions of a supernova ejecta. This, and the presence of unburned outer layer of carbon-oxygen may pose problems for SNIa spectra. Explosion sensitivity to initial conditions and its relation to a diversity of SNIa is discussed.

Spectral Sequences of Type Ia Supernovae. I. Connecting Normal and Subluminous SNe Ia and the Presence of Unburned Carbon

Energy Technology Data Exchange (ETDEWEB)

Heringer, E.; Kerkwijk, M. H. van [Department of Astronomy and Astrophysics, University of Toronto, 50 Saint George Street, Toronto, ON M5S 3H4 (Canada); Sim, S. A. [Astrophysics Research Centre, School of Mathematics and Physics, Queens University Belfast, Belfast BT7 1NN (United Kingdom); Kerzendorf, W. E. [European Southern Observatory (ESO), Karl-Schwarzschild-Straße 2, D-85748 Garching (Germany)

2017-09-01

Type Ia supernovae (SNe Ia) are generally agreed to arise from thermonuclear explosions of carbon–oxygen white dwarfs. The actual path to explosion, however, remains elusive, with numerous plausible parent systems and explosion mechanisms suggested. Observationally, SNe Ia have multiple subclasses, distinguished by their light curves and spectra. This raises the question of whether these indicate that multiple mechanisms occur in nature or that explosions have a large but continuous range of physical properties. We revisit the idea that normal and 91bg-like SNe can be understood as part of a spectral sequence in which changes in temperature dominate. Specifically, we find that a single ejecta structure is sufficient to provide reasonable fits of both the normal SN Ia SN 2011fe and the 91bg-like SN 2005bl, provided that the luminosity and thus temperature of the ejecta are adjusted appropriately. This suggests that the outer layers of the ejecta are similar, thus providing some support for a common explosion mechanism. Our spectral sequence also helps to shed light on the conditions under which carbon can be detected in premaximum SN Ia spectra—we find that emission from iron can “fill in” the carbon trough in cool SNe Ia. This may indicate that the outer layers of the ejecta of events in which carbon is detected are relatively metal-poor compared to events in which carbon is not detected.

Penerapan PSAK Adopsi IAS 41 Agriculture

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Stefanus Ariyanto

2014-05-01

Full Text Available This study aims to determine whether the application of PSAK adopted from IAS 41: Agriculture should be applied to State-Owned Enterprises, especially the plantation SOE. So that the SOE financial information produced becomes more useful for decision-making. Furthermore, this study wants to answer what benefits can be obtained from the implementation of this standard on the plantation-based SOE. The main characteristic of IAS is the use of fair value model for biological assets owned by the agriculture-based entity. The use of this model raises a lot of controversy, primarily, associated with relevant quality and reliability of the information it produces. Research used qualitative method with data collection through literature study, survey, interview, and observation. Survey and interview were divided into two major parts, which were: on the compilers of financial statements and the stakeholders. From this study it can be concluded that the PSAK based on IAS 41 have not to be implemented yet in the near future due to IAS 41 will undergo quite significant revision. Currently, the State-Owned Enterprises could use the PSAK plantation SOE that has been issued.

Adoption of IFRS/IAS impacting the companies

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Michaela Baranová

2013-11-01

Full Text Available In recent time, there were done marked changes in IAS/IFRS, changes in existing rules. Fifteen standards of IAS have been amended just before the end of 2003 and in course of the first quarter of the year 2004 updating of other standards IAS has been done. The requirement of changes hangs together, among others, also with the recent affairs about the bankruptcies of big companies. In this connection, accelerated and turning changes are proceeding in EU. Since 2005 every EU listed company has to prepare the consolidated financial statements in accordance with IFRS/IAS. Vast survey on the impacts of IFRS adoption was carried by Mazars in 2005. 25 Czech companies have been also interviewed within the study. These Czech companies have exhibit a strong mastery and readiness for the conversion and transition process. Such a summary is quite unwonted in a number of perspectives. But the aim of the author is not to question the study. In the Czech environment, the specific facts in the field of financial reporting and accounting are given. Following these specifics, the truth is that preparing the financial statements in accordance with IFRS/IAS brings undoubtedly valuation and technical entanglements for which the process is costly.

A Hubble Diagram of Distant Type IA Supernovae

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Hamuy, M.; Phillips, M. M.; Suntzeff, N. B.; Aviles, R.; Maza, J.

1993-12-01

Due to their extreme luminosities at maximum light, type Ia supernovae (SNe Ia) have long been considered among the most attractive cosmological standard candles. Although nearly all work to date has been devoted to attempts to use these objects to determine the local rate of expansion of the universe (Ho), SNe Ia also provide one of the few direct techniques for measuring the deceleration parameter qo. However, in a recent study of nine well-observed events based largely on data obtained at CTIO, Phillips (1993, ApJ, 413, L105) found clear evidence for a significant intrinsic dispersion in SNe Ia absolute magnitudes amounting to ~ 0.8 mag in B, ~ 0.7 mag in V, and ~ 0.5 mag in I. Such a range in peak luminosity could introduce a subtantial Malmquist bias into searches for distant (z rate of the B light curve. Interestingly, the most luminous SNe in our sample all occurred in spiral galaxies, which is true for Phillips' sample of nearby SNe Ia as well. This is opposite to what one would expect if dust extinction were important. These findings are consistent with recent speculations that the progenitors of SNe Ia are white dwarfs covering a range of masses, and also suggest that the brightest events may be found in galaxies which are still actively forming stars. The implications for the use of SNe Ia to measure qo are briefly discussed. This research has been supported by Grant 92/0312 from Fondo Nacional de Ciencias y Tecnología (FONDECYT-Chile).

Network models predict that reduced excitatory fluctuations can give rise to hippocampal network hyper-excitability in MeCP2-null mice.

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Ernest C Y Ho

Full Text Available Rett syndrome is a severe pediatric neurological disorder caused by loss of function mutations within the gene encoding methyl CpG-binding protein 2 (MeCP2. Although MeCP2 is expressed near ubiquitously, the primary pathophysiology of Rett syndrome stems from impairments of nervous system function. One alteration within different regions of the MeCP2-deficient brain is the presence of hyper-excitable network responses. In the hippocampus, such responses exist despite there being an overall decrease in spontaneous excitatory drive within the network. In this study, we generated and used mathematical, neuronal network models to resolve this apparent paradox. We did this by taking advantage of previous mathematical modelling insights that indicated that decreased excitatory fluctuations, but not mean excitatory drive, more critically explain observed changes in hippocampal network oscillations from MeCP2-null mouse slices. Importantly, reduced excitatory fluctuations could also bring about hyper-excitable responses in our network models. Therefore, these results indicate that diminished excitatory fluctuations may be responsible for the hyper-excitable state of MeCP2-deficient hippocampal circuitry.

IAS 25, Bilanzierung von Finanzinvestitionen (Accounting for Investments)

OpenAIRE

Steiner, Manfred

1997-01-01

IAS 25, Bilanzierung von Finanzinvestitionen (Accounting for Investments). - In: Rechnungslegung nach International Accounting Standards (IAS) / hrsg. von Jörg Baetge ... - Stuttgart : Schäffer-Poeschel, 1997. - S. 923-953

The Number of Positive Pelvic Lymph Nodes and Multiple Groups of Pelvic Lymph Node Metastasis Influence Prognosis in Stage IA-IIB Cervical Squamous Cell Carcinoma

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Yu Liu

2015-01-01

Full Text Available Background: Pelvic lymph node metastasis (LNM is an important prognostic factor in cervical cancer. Cervical squamous cell carcinoma accounts for approximately 75-80% of all cervical cancers. Analyses of the effects of the number of positive lymph nodes (LNs, unilateral versus bilateral pelvic LNM and a single group versus multiple groups of pelvic LNM on survival and recurrence of cervical squamous cell carcinoma are still lacking. The study aimed to analyze the effects of the number of positive pelvic LNs and a single group versus multiple groups of pelvic LNM on survival and recurrence. Methods: We performed a retrospective review of 296 patients diagnosed with Stage IA-IIB cervical squamous cell carcinoma who received extensive/sub-extensive hysterectomy with pelvic lymphadenectomy/pelvic LN sampling at Peking University People′s Hospital from November 2004 to July 2013. Ten clinicopathological variables were evaluated as risk factors for pelvic LNM: Age at diagnosis, gravidity, clinical stage, histological grade, tumor diameter, lymph-vascular space involvement (LVSI, depth of cervical stromal invasion, uterine invasion, parametrial invasion, and neoadjuvant chemotherapy. Results: The incidence of pelvic LNM was 20.27% (60/296 cases. Pelvic LNM (P = 0.00 was significantly correlated with recurrence. Pelvic LNM (P = 0.00, the number of positive pelvic LNs (P = 0.04 and a single group versus multiple groups of pelvic LNM (P = 0.03 had a significant influence on survival. Multivariate analysis revealed that LVSI (P = 0.00, depth of cervical stromal invasion (P = 0.00 and parametrial invasion (P = 0.03 were independently associated with pelvic LNM. Conclusions: Patients with pelvic LNM had a higher recurrence rate and poor survival outcomes. Furthermore, more than 2 positive pelvic LNs and multiple groups of pelvic LNM appeared to identify patients with worse survival outcomes in node-positive IA-IIB cervical squamous cell carcinoma. LVSI

Unsupervised discrimination of patterns in spiking neural networks with excitatory and inhibitory synaptic plasticity.

Science.gov (United States)

Srinivasa, Narayan; Cho, Youngkwan

2014-01-01

A spiking neural network model is described for learning to discriminate among spatial patterns in an unsupervised manner. The network anatomy consists of source neurons that are activated by external inputs, a reservoir that resembles a generic cortical layer with an excitatory-inhibitory (EI) network and a sink layer of neurons for readout. Synaptic plasticity in the form of STDP is imposed on all the excitatory and inhibitory synapses at all times. While long-term excitatory STDP enables sparse and efficient learning of the salient features in inputs, inhibitory STDP enables this learning to be stable by establishing a balance between excitatory and inhibitory currents at each neuron in the network. The synaptic weights between source and reservoir neurons form a basis set for the input patterns. The neural trajectories generated in the reservoir due to input stimulation and lateral connections between reservoir neurons can be readout by the sink layer neurons. This activity is used for adaptation of synapses between reservoir and sink layer neurons. A new measure called the discriminability index (DI) is introduced to compute if the network can discriminate between old patterns already presented in an initial training session. The DI is also used to compute if the network adapts to new patterns without losing its ability to discriminate among old patterns. The final outcome is that the network is able to correctly discriminate between all patterns-both old and new. This result holds as long as inhibitory synapses employ STDP to continuously enable current balance in the network. The results suggest a possible direction for future investigation into how spiking neural networks could address the stability-plasticity question despite having continuous synaptic plasticity.

Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex

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Yan-he Ju

2016-01-01

Full Text Available Pudendal nerve plays an important role in urine storage and voiding. Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury. We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve. This study explored the excitatory pudendal-to-bladder reflex in beagle dogs, with intact or injured spinal cord, by electrical stimulation of the pudendal nerve trunk. The optimal stimulation frequency was approximately 15-25 Hz. This excitatory effect was dependent to some extent on the bladder volume. We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function.

TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning

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Sarah X. Luo

2016-12-01

Full Text Available Neural circuits involving midbrain dopaminergic (DA neurons regulate reward and goal-directed behaviors. Although local GABAergic input is known to modulate DA circuits, the mechanism that controls excitatory/inhibitory synaptic balance in DA neurons remains unclear. Here, we show that DA neurons use autocrine transforming growth factor β (TGF-β signaling to promote the growth of axons and dendrites. Surprisingly, removing TGF-β type II receptor in DA neurons also disrupts the balance in TGF-β1 expression in DA neurons and neighboring GABAergic neurons, which increases inhibitory input, reduces excitatory synaptic input, and alters phasic firing patterns in DA neurons. Mice lacking TGF-β signaling in DA neurons are hyperactive and exhibit inflexibility in relinquishing learned behaviors and re-establishing new stimulus-reward associations. These results support a role for TGF-β in regulating the delicate balance of excitatory/inhibitory synaptic input in local microcircuits involving DA and GABAergic neurons and its potential contributions to neuropsychiatric disorders.

Traveling wave front solutions in lateral-excitatory neuronal networks

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Sittipong Ruktamatakul

2008-05-01

Full Text Available In this paper, we discuss the shape of traveling wave front solutions to a neuronal model with the connection function to be of lateral excitation type. This means that close connecting cells have an inhibitory influence, while cells that aremore distant have an excitatory influence. We give results on the shape of the wave fronts solutions, which exhibit different shapes depend ing on the size of a threshold parameter.

GABAergic activities control spike timing- and frequency-dependent long-term depression at hippocampal excitatory synapses

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Makoto Nishiyama

2010-06-01

Full Text Available GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and post-synaptic sites of hippocampal CA1 pyramidal cells differentially contribute to synaptic function and plasticity during their repetitive pre- and post-synaptic spiking at θ and γ oscillations is largely unknown. We show here that activities mediated by postsynaptic GABAARs and presynaptic GABABRs determine, respectively, the spike timing- and frequency-dependence of activity-induced synaptic modifications at Schaffer collateral-CA1 excitatory synapses. We demonstrate that both feedforward and feedback GABAAR-mediated inhibition in the postsynaptic cell controls the spike timing-dependent long-term depression of excitatory inputs (“e-LTD” at the θ frequency. We also show that feedback postsynaptic inhibition specifically causes e-LTD of inputs that induce small postsynaptic currents (<70 pA with LTP timing, thus enforcing the requirement of cooperativity for induction of long-term potentiation at excitatory inputs (“e-LTP”. Furthermore, under spike-timing protocols that induce e-LTP and e-LTD at excitatory synapses, we observed parallel induction of LTP and LTD at inhibitory inputs (“i-LTP” and “i-LTD” to the same postsynaptic cells. Finally, we show that presynaptic GABABR-mediated inhibition plays a major role in the induction of frequency-dependent e-LTD at α and β frequencies. These observations demonstrate the critical influence of GABAergic interneuronal network activities in regulating the spike timing and frequency dependences of long-term synaptic modifications in the hippocampus.

REVEALING TYPE Ia SUPERNOVA PHYSICS WITH COSMIC RATES AND NUCLEAR GAMMA RAYS

International Nuclear Information System (INIS)

Horiuchi, Shunsaku; Beacom, John F.

2010-01-01

Type Ia supernovae (SNe Ia) remain mysterious despite their central importance in cosmology and their rapidly increasing discovery rate. The progenitors of SNe Ia can be probed by the delay time between progenitor birth and explosion as SNe Ia. The explosions and progenitors of SNe Ia can be probed by MeV nuclear gamma rays emitted in the decays of radioactive nickel and cobalt into iron. We compare the cosmic star formation and SN Ia rates, finding that their different redshift evolution requires a large fraction of SNe Ia to have large delay times. A delay-time distribution of the form t -α with α = 1.0 ± 0.3 provides a good fit, implying that 50% of SNe Ia explode more than ∼1 Gyr after progenitor birth. The extrapolation of the cosmic SN Ia rate to z = 0 agrees with the rate we deduce from catalogs of local SNe Ia. We investigate prospects for gamma-ray telescopes to exploit the facts that escaping gamma rays directly reveal the power source of SNe Ia and uniquely provide tomography of the expanding ejecta. We find large improvements relative to earlier studies by Gehrels et al. in 1987 and Timmes and Woosley in 1997 due to larger and more certain SN Ia rates and advances in gamma-ray detectors. The proposed Advanced Compton Telescope, with a narrow-line sensitivity ∼60 times better than that of current satellites, would, on an annual basis, detect up to ∼100 SNe Ia (3σ) and provide revolutionary model discrimination for SNe Ia within 20 Mpc, with gamma-ray light curves measured with ∼10σ significance daily for ∼100 days. Even more modest improvements in detector sensitivity would open a new and invaluable astronomy with frequent SN Ia gamma-ray detections.

CIRCUMSTELLAR SHELLS IN ABSORPTION IN TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Borkowski, Kazimierz J.; Blondin, John M.; Reynolds, Stephen P.

2009-01-01

Progenitors of Type Ia supernovae (SNe) have been predicted to modify their ambient circumstellar (CSM) and interstellar environments through the action of their powerful winds. While there is X-ray and optical evidence for circumstellar interaction in several remnants of Type Ia SNe, widespread evidence for such interaction in Type Ia SNe themselves has been lacking. We consider prospects for the detection of CSM shells that have been predicted to be common around Type Ia SNe. Such shells are most easily detected in Na I absorption lines. Variable (declining) absorption is expected to occur soon after the explosion, primarily during the SN rise time, for shells located within ∼1-10 pc of a SN. The distance of the shell from the SN can be determined by measuring the timescale for line variability.

Low-z Type Ia Supernova Calibration

Science.gov (United States)

Hamuy, Mario

The discovery of acceleration and dark energy in 1998 arguably constitutes one of the most revolutionary discoveries in astrophysics in recent years. This paradigm shift was possible thanks to one of the most traditional cosmological tests: the redshift-distance relation between galaxies. This discovery was based on a differential measurement of the expansion rate of the universe: the current one provided by nearby (low-z) type Ia supernovae and the one in the past measured from distant (high-z) supernovae. This paper focuses on the first part of this journey: the calibration of the type Ia supernova luminosities and the local expansion rate of the universe, which was made possible thanks to the introduction of digital CCD (charge-coupled device) digital photometry. The new technology permitted us in the early 1990s to convert supernovae as precise tools to measure extragalactic distances through two key surveys: (1) the "Tololo Supernova Program" which made possible the critical discovery of the "peak luminosity-decline rate" relation for type Ia supernovae, the key underlying idea today behind precise cosmology from supernovae, and (2) the Calán/Tololo project which provided the low - z type Ia supernova sample for the discovery of acceleration.

Tratamento das cefaléias Treatment of headaches

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José Luiz Dias Gherpelli

2002-08-01

Full Text Available Objetivo: realizar revisão bibliográfica sobre o tema tratamento da cefaléia na infância e adolescência. Fontes dos dados: revisão bibliográfica através do banco de dados Medline, utilizando os termos: cefaléia, enxaqueca ou migrânea, infância ou adolescência e tratamento, no período de 1966 a 2001, excluindo artigos de revisão e registros de casos. Foram selecionados artigos científicos que relataram estudos sobre a eficácia da terapêutica farmacológica e não farmacológica no tratamento das cefaléias primárias. Síntese dos dados: foram encontrados 104 artigos científicos, sendo selecionados aqueles que relataram estudos do tipo caso-controle, ou droga versus placebo, cegos ou abertos, e que estudassem crianças ou adolescentes. Conclusões: é digna de nota a pobreza de estudos controlados sobre o tema na faixa etária pediátrica, apesar da importância que as cefaléias primárias apresentam na prática clínica. Apenas algumas drogas foram estudadas de forma cientificamente adequada e, mesmo assim, o número de estudos é pequeno. Tanto o tratamento da crise álgica aguda quanto a profilaxia da cefaléia foram abordados.Objective: to perform a bibliographic review about headache treatment in childhood and adolescence. Sources: articles were searched through Medline database using the terms: migraine, or headache, childhood, or adolescence, and treatment, during the period between 1966 and 2001. Review articles and case reports were excluded. Only articles dealing with pharmacological, and non-pharmacological treatment of primary headaches were selected. Summary of the findings: a total of 104 articles were found; only those reporting results of the case-control studies, or drug vs. placebo, either blind, or open, and that included children, or adolescents were selected. Conclusions: only a few controlled studies about the headache treatment were found in the pediatric age group, although primary headaches are

Thematic trip: "Save Roşia MontanÄă"

Science.gov (United States)

Eugenia, Marcu

2015-04-01

The name Roşia Montană, situated in Transylvania, became well known after a Romanian-Canadian company, Roşia Montană Gold Company (RMGC), obtained the concession license on exploitation for gold and silver minerals in the Roşia Montană area. The project consists of opening the largest surface gold mines in Europe using cyanide, which will include four open pits and a processing plant for gold and silver in The Roşia Valley and a tailings facility with an area of 367 hectares in the Corna Valley. One of the main fears is related to a possible ecological accident like the one in Baia Mare in 2000, when a tailing facility dam break led to cyanide pollution of Tisa and Danube rivers that resulted in the death of 1,200 tons of fish and contamination of water resources for 2 million people. This thematic trip is important for the scientific preparation of students and an opportunity to educate them in the spirit of environmental protection. The training and education of students will require assimilation and understanding, actively and consciously, using the knowledge acquired during the compulsory curriculum and training skills. REASON: The continuous degradation of the environment is a major crisis due to human intervention in nature, and the proposed Roşia Montană mining project will continue this trend. The company proposes to extract gold from mines by using the gold separation technique using cyanide, a process that involves destroying a total area of 16 km² which includes 5 mountains, 7 churches, 11 cemeteries and the ruins of Alburnus Maior Citadel, as well as creating pollution that would last for hundreds of years. The extraction of gold from low-grade ores using cyanide processes was estimated to result in a worldwide emission of 45,300 tons of hydrogen cyanide. Environmental education for a healthy life has children as target group, because they are the trustees and beneficiaries of tomorrow's natural resources and can influence the attitudes of

77 FR 4459 - Amendment of Class E Airspace; Greenfield, IA

Science.gov (United States)

2012-01-30

...-0846; Airspace Docket No. 11-ACE-18] Amendment of Class E Airspace; Greenfield, IA AGENCY: Federal... Greenfield, IA. Decommissioning of the Greenfield non-directional beacon (NDB) at Greenfield Municipal... rulemaking to amend Class E airspace for Greenfield, IA, reconfiguring controlled airspace at Greenfield...

75 FR 23581 - Amendment of Class E Airspace; Emmetsburg, IA

Science.gov (United States)

2010-05-04

...-1153; Airspace Docket No. 09-ACE-13] Amendment of Class E Airspace; Emmetsburg, IA AGENCY: Federal... Emmetsburg, IA, adding additional controlled airspace to accommodate Area Navigation (RNAV) Standard Instrument Approach Procedures (SIAPs) at Emmetsburg Municipal Airport, Emmetsburg, IA. The FAA is taking...

Glucose rapidly induces different forms of excitatory synaptic plasticity in hypothalamic POMC neurons.

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Jun Hu

Full Text Available Hypothalamic POMC neurons are required for glucose and energy homeostasis. POMC neurons have a wide synaptic connection with neurons both within and outside the hypothalamus, and their activity is controlled by a balance between excitatory and inhibitory synaptic inputs. Brain glucose-sensing plays an essential role in the maintenance of normal body weight and metabolism; however, the effect of glucose on synaptic transmission in POMC neurons is largely unknown. Here we identified three types of POMC neurons (EPSC(+, EPSC(-, and EPSC(+/- based on their glucose-regulated spontaneous excitatory postsynaptic currents (sEPSCs, using whole-cell patch-clamp recordings. Lowering extracellular glucose decreased the frequency of sEPSCs in EPSC(+ neurons, but increased it in EPSC(- neurons. Unlike EPSC(+ and EPSC(- neurons, EPSC(+/- neurons displayed a bi-phasic sEPSC response to glucoprivation. In the first phase of glucoprivation, both the frequency and the amplitude of sEPSCs decreased, whereas in the second phase, they increased progressively to the levels above the baseline values. Accordingly, lowering glucose exerted a bi-phasic effect on spontaneous action potentials in EPSC(+/- neurons. Glucoprivation decreased firing rates in the first phase, but increased them in the second phase. These data indicate that glucose induces distinct excitatory synaptic plasticity in different subpopulations of POMC neurons. This synaptic remodeling is likely to regulate the sensitivity of the melanocortin system to neuronal and hormonal signals.

Glucose rapidly induces different forms of excitatory synaptic plasticity in hypothalamic POMC neurons.

Science.gov (United States)

Hu, Jun; Jiang, Lin; Low, Malcolm J; Rui, Liangyou

2014-01-01

Hypothalamic POMC neurons are required for glucose and energy homeostasis. POMC neurons have a wide synaptic connection with neurons both within and outside the hypothalamus, and their activity is controlled by a balance between excitatory and inhibitory synaptic inputs. Brain glucose-sensing plays an essential role in the maintenance of normal body weight and metabolism; however, the effect of glucose on synaptic transmission in POMC neurons is largely unknown. Here we identified three types of POMC neurons (EPSC(+), EPSC(-), and EPSC(+/-)) based on their glucose-regulated spontaneous excitatory postsynaptic currents (sEPSCs), using whole-cell patch-clamp recordings. Lowering extracellular glucose decreased the frequency of sEPSCs in EPSC(+) neurons, but increased it in EPSC(-) neurons. Unlike EPSC(+) and EPSC(-) neurons, EPSC(+/-) neurons displayed a bi-phasic sEPSC response to glucoprivation. In the first phase of glucoprivation, both the frequency and the amplitude of sEPSCs decreased, whereas in the second phase, they increased progressively to the levels above the baseline values. Accordingly, lowering glucose exerted a bi-phasic effect on spontaneous action potentials in EPSC(+/-) neurons. Glucoprivation decreased firing rates in the first phase, but increased them in the second phase. These data indicate that glucose induces distinct excitatory synaptic plasticity in different subpopulations of POMC neurons. This synaptic remodeling is likely to regulate the sensitivity of the melanocortin system to neuronal and hormonal signals.

Ciclos : estudo de casos de ecodesign de jóias

OpenAIRE

Luiz Marcelo Straliotto

2009-01-01

Esta dissertação demonstra a possibilidade de aplicação dos princípios ecológicos no design de jóias com o objetivo de contribuir para a sistematização do conhecimento sobre o ecodesign de jóias. Num primeiro momento, a fundamentação teórica foi realizada por meio de pesquisa exploratória e descritiva, apoiada pela revisão e discussão da literatura técnica e científica sobre jóia, design de jóias e ecodesign de produtos. Essa etapa forneceu os subsídios para o desenvolvimento das jóias ecológ...

Theoretical considerations about implementation of IAS 41 in Romania

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Liliana FELEAGĂ

2012-02-01

Full Text Available Although agriculture is an important part of the world economy, accounting in agriculture still has many shortcomings. The adoption of IAS 41 „Agricuture” has tried to improve this situation and increase the comparability of financial statements of entities in the agricultural sector. Although controversial, IAS 41 is the first step of a consistent transition to fair value assessment in the agricultural sector. The objective of our work is the analysis of IAS 41 and current accounting agricultural situation in Romania. Accounting regulations in Romania are in accordance with European directives and, in many respects, converged with IFRS referential. Provisions of IAS 41, however, are not reflected directly in Romanian regulations. With the increase of forest land transactions and foreign investments in animal farms, it is expected that recognition and measurement of biological assets under IAS 41 to become a necessity.

75 FR 23580 - Amendment of Class E Airspace; Mapleton, IA

Science.gov (United States)

2010-05-04

...-1155; Airspace Docket No. 09-ACE-14] Amendment of Class E Airspace; Mapleton, IA AGENCY: Federal... Mapleton, IA, adding additional controlled airspace to accommodate Area Navigation (RNAV) Standard Instrument Approach Procedures (SIAPs) at James G. Whiting Memorial Field Airport, Mapleton, IA. The FAA is...

76 FR 75449 - Establishment of Class E Airspace; Stuart, IA

Science.gov (United States)

2011-12-02

...-0831; Airspace Docket No. 11-ACE-17] Establishment of Class E Airspace; Stuart, IA AGENCY: Federal... for Stuart, IA, to accommodate new COPTER area navigation (RNAV) Standard Instrument Approach... Federal Register a notice of proposed rulemaking to establish Class E airspace for Stuart, IA, creating...

WD+RG systems as the progenitors of type Ia supernovae

International Nuclear Information System (INIS)

Wang Bo; Han Zhanwen

2010-01-01

Type Ia supernovae (SNe Ia) play an important role in the study of cosmic evolution, especially in cosmology. There are several progenitor models for SNe Ia proposed in the past years. By considering the effect of accretion disk instability on the evolution of white dwarf (WD) binaries, we performed detailed binary evolution calculations for the WD + red-giant (RG) channel of SNe Ia, in which a carbon-oxygen WD accretes material from a RG star to increase its mass to the Chandrasekhar mass limit. According to these calculations, we mapped out the initial and final parameters for SNe Ia in the orbital period-secondary mass (log P i - M i 2 ) plane for various WD masses for this channel. We discussed the influence of the variation of the duty cycle value on the regions for producing SNe Ia. Similar to previous studies, this work also indicates that the long-period dwarf novae offer possible ways for producing SNe Ia. Meanwhile, we find that the surviving companion stars from this channel have a low mass after the SN explosion, which may provide a means for the formation of the population of single low-mass WDs ( o-dot ).

The Influence of Host Galaxies in Type Ia Supernova Cosmology

Energy Technology Data Exchange (ETDEWEB)

Uddin, Syed A. [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing, Jiangshu (China); Mould, Jeremy [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Melbourne, VIC (Australia); Lidman, Chris; Zhang, Bonnie R. [Australian Research Council Centre of Excellence for All-sky Astrophysics (CAASTRO) (Australia); Ruhlmann-Kleider, Vanina, E-mail: saushuvo@gmail.com [CEA, Centre de Saclay, Irfu/SPP, F-91191 Gif-sur-Yvette, Paris (France)

2017-10-10

We use a sample of 1338 spectroscopically confirmed and photometrically classified Type Ia supernovae (SNe Ia) sourced from Carnegie Supernova Project, Center for Astrophysics Supernova Survey, Sloan Digital Sky Survey-II, and SuperNova Legacy Survey SN samples to examine the relationships between SNe Ia and the galaxies that host them. Our results provide confirmation with improved statistical significance that SNe Ia, after standardization, are on average more luminous in massive hosts (significance >5 σ ), and decline more rapidly in massive hosts (significance >9 σ ) and in hosts with low specific star formation rates (significance >8 σ ). We study the variation of these relationships with redshift and detect no evolution. We split SNe Ia into pairs of subsets that are based on the properties of the hosts and fit cosmological models to each subset. Including both systematic and statistical uncertainties, we do not find any significant shift in the best-fit cosmological parameters between the subsets. Among different SN Ia subsets, we find that SNe Ia in hosts with high specific star formation rates have the least intrinsic scatter ( σ {sub int} = 0.08 ± 0.01) in luminosity after standardization.

77 FR 68682 - Amendment of Class E Airspace; Guthrie, IA

Science.gov (United States)

2012-11-16

...-1436; Airspace Docket No. 11-ACE-29] Amendment of Class E Airspace; Guthrie, IA AGENCY: Federal... Guthrie, IA. Decommissioning of the Guthrie Center non-directional radio beacon (NDB) at Guthrie County... proposed rulemaking (NPRM) to amend Class E airspace for the Guthrie, IA, area, creating additional...

78 FR 76053 - Amendment of Class E Airspace; Chariton, IA

Science.gov (United States)

2013-12-16

...-0255; Airspace Docket No. 13-ACE-4] Amendment of Class E Airspace; Chariton, IA AGENCY: Federal... Chariton, IA. Decommissioning of the Chariton non-directional beacon (NDB) at Chariton Municipal Airport... Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Chariton, IA, area...

75 FR 37292 - Amendment of Class E Airspace; Cherokee, IA

Science.gov (United States)

2010-06-29

...-0085; Airspace Docket No. 10-ACE-1] Amendment of Class E Airspace; Cherokee, IA AGENCY: Federal... Cherokee, IA. Decommissioning of the Pilot Rock non-directional beacon (NDB) at Cherokee County Regional Airport, Cherokee, IA has made this action necessary to enhance the safety and management of Instrument...

IA-2 autoantibody affinity in children at risk for type 1 diabetes.

Science.gov (United States)

Krause, Stephanie; Chmiel, Ruth; Bonifacio, Ezio; Scholz, Marlon; Powell, Michael; Furmaniak, Jadwiga; Rees Smith, Bernard; Ziegler, Anette-G; Achenbach, Peter

2012-12-01

Autoantibodies to insulinoma-associated protein 2 (IA-2A) are associated with increased risk for type 1 diabetes. Here we examined IA-2A affinity and epitope specificity to assess heterogeneity in response intensity in relation to pathogenesis and diabetes risk in 50 children who were prospectively followed from birth. At first IA-2A appearance, affinity ranged from 10(7) to 10(11)L/mol and was high (>1.0×10(9)L/mol) in 41 (82%) children. IA-2A affinity was not associated with epitope specificity or HLA class II haplotype. On follow-up, affinity increased or remained high, and IA-2A were commonly against epitopes within the protein tyrosine phosphatase-like IA-2 domain and the homologue protein IA-2β. IA-2A were preceded or accompanied by other islet autoantibodies in 49 (98%) children, of which 34 progressed to diabetes. IA-2A affinity did not stratify diabetes risk. In conclusion, the IA-2A response in children is intense with rapid maturation against immunogenic epitopes and a strong association with diabetes development. Copyright © 2012 Elsevier Inc. All rights reserved.

77 FR 66067 - Amendment of Class E Airspace; Boone, IA

Science.gov (United States)

2012-11-01

...-1432; Airspace Docket No. 11-ACE-25] Amendment of Class E Airspace; Boone, IA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace at Boone, IA... proposed rulemaking (NPRM) to amend Class E airspace for the Boone, IA, area, creating additional...

77 FR 66069 - Amendment of Class E Airspace; Perry, IA

Science.gov (United States)

2012-11-01

...-1435; Airspace Docket No. 11-ACE-28] Amendment of Class E Airspace; Perry, IA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E airspace at Perry, IA... proposed rulemaking (NPRM) to amend Class E airspace for the Perry, IA, area, creating additional...

77 FR 42427 - Amendment of Class E Airspace; Grinnell, IA

Science.gov (United States)

2012-07-19

...-1430; Airspace Docket No. 11-ACE-23] Amendment of Class E Airspace; Grinnell, IA AGENCY: Federal... Class E airspace at Grinnell Regional Airport, Grinnell, IA, by removing reference to the Grinnell NDB... Regional Airport, Grinnell, IA, and amends the geographic coordinates of the airport to coincide with the...

76 FR 73501 - Amendment of Class E Airspace; Carroll, IA

Science.gov (United States)

2011-11-29

...-0845; Airspace Docket No. 11-ACE-19] Amendment of Class E Airspace; Carroll, IA AGENCY: Federal... Carroll, IA. Decommissioning of the Carroll non-directional beacon (NDB) at Arthur N. Neu Airport, Carroll, IA, has made this action necessary to enhance the safety and management of Instrument Flight Rule...

76 FR 75447 - Amendment of Class E Airspace; Centerville, IA

Science.gov (United States)

2011-12-02

...-0830; Airspace Docket No. 11-ACE-16] Amendment of Class E Airspace; Centerville, IA AGENCY: Federal... Centerville, IA. Decommissioning of the Centerville non-directional beacon (NDB) and cancellation of the NDB... Federal Register a notice of proposed rulemaking to amend Class E airspace for the Centerville, IA, area...

78 FR 18800 - Amendment of Class E Airspace; Decorah, IA

Science.gov (United States)

2013-03-28

...-1433; Airspace Docket No. 11-ACE-26] Amendment of Class E Airspace; Decorah, IA AGENCY: Federal... Decorah, IA. Decommissioning of the Decorah non-directional beacon (NDB) at Decorah Municipal Airport has... Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Decorah, IA, area...

Non-Local Thermodynamic Equilibrium Spectrum Synthesis of Type IA Supernovae

Science.gov (United States)

Nugent, Peter Edward

1997-09-01

Type Ia supernovae (SNe Ia) are valuable distance indicators for cosmology and the elements they eject are are important for nucleosynthesis. They appear to be thermonuclear disruptions of carbon-oxygen white dwarfs that accrete from companion stars until they approach the Chandrasekbar mass, and there is a suspicion that the propagation of the nuclear burning front involves a transition from a deflagration to a detonation. Detailed modeling of the atmospheres and spectra of SNe Ia is needed to advance our understanding of SNe Ia. Comparison of synthetic and observed spectra provides information on the temperature, density, velocity, and composition of the ejected matter and thus constrain hydrodynamical models. In addition, the expanding photosphere method yields distances to individual events that are independent of distances based on the decay of 56Ni in SNe Ia and of Cepheid variable stars in the parent galaxies. This thesis is broken down into 4 major sections, each highlighting a different way with which to use spectrum synthesis to analyze SNe Ia. Chapters 2 and 3 look at normal SNe Ia and their potential use as distance indicators using SEAM. Chapter 4 examines spectral correlations with luminosity in SNe Ia and provides a plausible explanation for these correlations via spectrum synthesis. In Chapter 5 the spectra of various hydrodynamical models are calculated in an effort to answer the question of which current progenitor/explosion model is the most plausible for a SN Ia. Finally, we look at the importance of NLTE calculations and line identifications in Chapter 6. Also included are two appendices which contain more technical information concerning γ-ray deposition and the thermalization parameter.

THE IMPACT OF METALLICITY ON THE RATE OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Kistler, Matthew D.; Stanek, K. Z.; Kochanek, Christopher S.; Thompson, Todd A.; Prieto, José L.

2013-01-01

The metallicity of a star strongly affects both its evolution and the properties of the stellar remnant that results from its demise. It is generally accepted that stars with initial masses below ∼8 M ☉ leave behind white dwarfs and that some sub-population of these lead to Type Ia supernovae (SNe Ia). However, it is often tacitly assumed that metallicity has no effect on the rate of SNe Ia. We propose that a consequence of the effects of metallicity is to significantly increase the SN Ia rate in lower-metallicity galaxies, in contrast to previous expectations. This is because lower-metallicity stars leave behind higher-mass white dwarfs, which should be easier to bring to explosion. We first model SN Ia rates in relation to galaxy masses and ages alone, finding that the elevation in the rate of SNe Ia in lower-mass galaxies measured by Lick Observatory SN Search is readily explained. However, we then see that models incorporating this effect of metallicity agree just as well. Using the same parameters to estimate the cosmic SN Ia rate, we again find good agreement with data up to z ≈ 2. We suggest that this degeneracy warrants more detailed examination of host galaxy metallicities. We discuss additional implications, including for hosts of high-z SNe Ia, the SN Ia delay time distribution, super-Chandrasekhar SNe, and cosmology.

Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes.

Directory of Open Access Journals (Sweden)

Gregory R Rompala

Full Text Available Pharmacological and genetic studies support a role for NMDA receptor (NMDAR hypofunction in the etiology of schizophrenia. We have previously demonstrated that NMDAR obligatory subunit 1 (GluN1 deletion in corticolimbic interneurons during early postnatal development is sufficient to confer schizophrenia-like phenotypes in mice. However, the consequence of NMDAR hypofunction in cortical excitatory neurons is not well delineated. Here, we characterize a conditional knockout mouse strain (CtxGluN1 KO mice, in which postnatal GluN1 deletion is largely confined to the excitatory neurons in layer II/III of the medial prefrontal cortex and sensory cortices, as evidenced by the lack of GluN1 mRNA expression in in situ hybridization immunocytochemistry as well as the lack of NMDA currents with in vitro recordings. Mutants were impaired in prepulse inhibition of the auditory startle reflex as well as object-based short-term memory. However, they did not exhibit impairments in additional hallmarks of schizophrenia-like phenotypes (e.g. spatial working memory, social behavior, saccharine preference, novelty and amphetamine-induced hyperlocomotion, and anxiety-related behavior. Furthermore, upon administration of the NMDA receptor antagonist, MK-801, there were no differences in locomotor activity versus controls. The mutant mice also showed negligible levels of reactive oxygen species production following chronic social isolation, and recording of miniature-EPSC/IPSCs from layer II/III excitatory neurons in medial prefrontal cortex suggested no alteration in GABAergic activity. All together, the mutant mice displayed cognitive deficits in the absence of additional behavioral or cellular phenotypes reflecting schizophrenia pathophysiology. Thus, NMDAR hypofunction in prefrontal and cortical excitatory neurons may recapitulate only a cognitive aspect of human schizophrenia symptoms.

Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes.

Science.gov (United States)

Rompala, Gregory R; Zsiros, Veronika; Zhang, Shuqin; Kolata, Stefan M; Nakazawa, Kazu

2013-01-01

Pharmacological and genetic studies support a role for NMDA receptor (NMDAR) hypofunction in the etiology of schizophrenia. We have previously demonstrated that NMDAR obligatory subunit 1 (GluN1) deletion in corticolimbic interneurons during early postnatal development is sufficient to confer schizophrenia-like phenotypes in mice. However, the consequence of NMDAR hypofunction in cortical excitatory neurons is not well delineated. Here, we characterize a conditional knockout mouse strain (CtxGluN1 KO mice), in which postnatal GluN1 deletion is largely confined to the excitatory neurons in layer II/III of the medial prefrontal cortex and sensory cortices, as evidenced by the lack of GluN1 mRNA expression in in situ hybridization immunocytochemistry as well as the lack of NMDA currents with in vitro recordings. Mutants were impaired in prepulse inhibition of the auditory startle reflex as well as object-based short-term memory. However, they did not exhibit impairments in additional hallmarks of schizophrenia-like phenotypes (e.g. spatial working memory, social behavior, saccharine preference, novelty and amphetamine-induced hyperlocomotion, and anxiety-related behavior). Furthermore, upon administration of the NMDA receptor antagonist, MK-801, there were no differences in locomotor activity versus controls. The mutant mice also showed negligible levels of reactive oxygen species production following chronic social isolation, and recording of miniature-EPSC/IPSCs from layer II/III excitatory neurons in medial prefrontal cortex suggested no alteration in GABAergic activity. All together, the mutant mice displayed cognitive deficits in the absence of additional behavioral or cellular phenotypes reflecting schizophrenia pathophysiology. Thus, NMDAR hypofunction in prefrontal and cortical excitatory neurons may recapitulate only a cognitive aspect of human schizophrenia symptoms.

Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex

Science.gov (United States)

Kunz, Portia A; Burette, Alain C; Weinberg, Richard J; Philpot, Benjamin D

2012-01-01

Glycine receptors (GlyRs) are found in most areas of the brain, and their dysfunction can cause severe neurological disorders. While traditionally thought of as inhibitory receptors, presynaptic-acting GlyRs (preGlyRs) can also facilitate glutamate release under certain circumstances, although the underlying molecular mechanisms are unknown. In the current study, we sought to better understand the role of GlyRs in the facilitation of excitatory neurotransmitter release in mouse visual cortex. Using whole-cell recordings, we found that preGlyRs facilitate glutamate release in developing, but not adult, visual cortex. The glycinergic enhancement of neurotransmitter release in early development depends on the high intracellular to extracellular Cl− gradient maintained by the Na+–K+–2Cl− cotransporter and requires Ca2+ entry through voltage-gated Ca2+ channels. The glycine transporter 1, localized to glial cells, regulates extracellular glycine concentration and the activation of these preGlyRs. Our findings demonstrate a developmentally regulated mechanism for controlling excitatory neurotransmitter release in the neocortex. PMID:22988142

Nearby Type Ia Supernova Follow-up at the Thacher Observatory

Science.gov (United States)

Swift, Jonathan; O'Neill, Katie; Kilpatrick, Charles; Foley, Ryan

2018-06-01

Type Ia supernovae (SN Ia) provide an effective way to study the expansion of the universe through analyses of their photometry and spectroscopy. The interpretation of high-redshift SN Ia is dependent on accurate characterization of nearby, low-redshift targets. To help build up samples of nearby SN Ia, the Thacher Observatory has begun a photometric follow-up program in 4 photometric bands. Here we present the observations and analysis of multi-band photometry for several recent supernovae as well as FLOYDS spectra from the Las Cumbres Observatory.

IAS 41 Implementation Challenges – The Case of Romania

OpenAIRE

Liliana Feleagă; Niculae Feleagă; Vasile Răileanu

2012-01-01

Although agriculture is an important part of the world economy, accounting in agriculture still has many shortcomings. The adoption of IAS 41 "Agriculture" has tried to improve this situation and increase the comparability of financial statements of entities in the agricultural sector. Although controversial, IAS 41 is the first step of a consistent transition to fair value assessment in the agricultural sector. The objective of our work is the analysis of IAS 41 and curr...

Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain

NARCIS (Netherlands)

van de Lagemaat, Louie N; Nijhof, Bonnie; Bosch, Daniëlle G M; Kohansal-Nodehi, Mahdokht; Keerthikumar, Shivakumar; Heimel, J.A.

2014-01-01

Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social interaction and communication, and restricted behavior and interests. A disruption in the balance of excitatory and inhibitory neurotransmission has been hypothesized to underlie these disorders. Here

IAS 39 og konverterbar gæld

DEFF Research Database (Denmark)

Fredslund Møller, Peder; Thinggaard, Frank

, at der er en betydelig beholdning af konverterbare realkreditlån, som der skal aflægges regnskab for. Denne artikel har til formål at belyse de alternativer, der findes i IAS39 til regnskabsmæssig behandling af konverterbar gæld. I juli 2008 kom der en tilføjelse til IAS 39, "Eligible Hedged Items". Den......: 1. dagsværdimetode, hvor "hele det konverterbare lån", dvs. både den "rene gæld" og den indbyggede indfrielsesoption, der iflg. IAS 39 udgør de to komponenter i et konverterbart lån, føres til dagsværdi, 2. udskillelsesmetode, hvor der anvendes amortiseret kostpris for den "rene gæld" og dagsværdi...

Penerapan PSAK Adopsi IAS 41 Agriculture

OpenAIRE

Ariyanto, Stefanus; Sukendar, Heri; Kurniawati, Heny

2014-01-01

This study aims to determine whether the application of PSAK adopted from IAS 41: Agriculture should be applied to State-Owned Enterprises, especially the plantation SOE. So that the SOE financial information produced becomes more useful for decision-making. Furthermore, this study wants to answer what benefits can be obtained from the implementation of this standard on the plantation-based SOE. The main characteristic of IAS is the use of fair value model for biological assets owned by the a...

Asymmetric Explosion of Type Ia Supernovae and Their Observational Signatures

International Nuclear Information System (INIS)

Maeda, Keiichi

2010-01-01

The nature of Type Ia supernova (SN Ia) explosions has not yet been clarified, despite their importance in astrophysics and cosmology. Recent theoretical investigations suggest that asymmetric distribution of initial thermonuclear sparks may be a key in the SN Ia explosion mechanism. In this paper, the first observational evidence of the asymmetry in SN Ia explosions is presented: We have found that late-time nebular spectra of various SNe Ia show a diversity in wavelengths of emission lines. This feature is inconsistent with any spherically symmetric explosion models, and indicates that the innermost region, a likely product of the deflagration wave propagation, shows an off-set with respect to the explosion center. The diversity in the emission-line wavelengths could naturally be explained by a combination of different viewing angles.

Intrinsically-generated fluctuating activity in excitatory-inhibitory networks

Science.gov (United States)

Mastrogiuseppe, Francesca; Ostojic, Srdjan

2017-01-01

Recurrent networks of non-linear units display a variety of dynamical regimes depending on the structure of their synaptic connectivity. A particularly remarkable phenomenon is the appearance of strongly fluctuating, chaotic activity in networks of deterministic, but randomly connected rate units. How this type of intrinsically generated fluctuations appears in more realistic networks of spiking neurons has been a long standing question. To ease the comparison between rate and spiking networks, recent works investigated the dynamical regimes of randomly-connected rate networks with segregated excitatory and inhibitory populations, and firing rates constrained to be positive. These works derived general dynamical mean field (DMF) equations describing the fluctuating dynamics, but solved these equations only in the case of purely inhibitory networks. Using a simplified excitatory-inhibitory architecture in which DMF equations are more easily tractable, here we show that the presence of excitation qualitatively modifies the fluctuating activity compared to purely inhibitory networks. In presence of excitation, intrinsically generated fluctuations induce a strong increase in mean firing rates, a phenomenon that is much weaker in purely inhibitory networks. Excitation moreover induces two different fluctuating regimes: for moderate overall coupling, recurrent inhibition is sufficient to stabilize fluctuations; for strong coupling, firing rates are stabilized solely by the upper bound imposed on activity, even if inhibition is stronger than excitation. These results extend to more general network architectures, and to rate networks receiving noisy inputs mimicking spiking activity. Finally, we show that signatures of the second dynamical regime appear in networks of integrate-and-fire neurons. PMID:28437436

The first IA-64 microprocessor

CERN Document Server

Rusu, S

2000-01-01

The first implementation of the IA-64 architecture achieves high performance by using a highly parallel execution core, while maintaining binary compatibility with the IA-32 instruction set. Explicitly parallel instruction computing (EPIC) design maximizes performance through hardware and software synergy. The processor contains 25.4 million transistors and operates at 800 MHz. The chip is fabricated in a 0.18- mu m CMOS process with six metal layers and packaged in a 1012-pad organic land grid array using C4 (flip chip) assembly technology. A core speed back-side bus connects the processor to a 4-MB L3 cache. (6 refs).

Dynamics of excitatory and inhibitory networks are differentially altered by selective attention

Science.gov (United States)

Snyder, Adam C.; Morais, Michael J.

2016-01-01

Inhibition and excitation form two fundamental modes of neuronal interaction, yet we understand relatively little about their distinct roles in service of perceptual and cognitive processes. We developed a multidimensional waveform analysis to identify fast-spiking (putative inhibitory) and regular-spiking (putative excitatory) neurons in vivo and used this method to analyze how attention affects these two cell classes in visual area V4 of the extrastriate cortex of rhesus macaques. We found that putative inhibitory neurons had both greater increases in firing rate and decreases in correlated variability with attention compared with putative excitatory neurons. Moreover, the time course of attention effects for putative inhibitory neurons more closely tracked the temporal statistics of target probability in our task. Finally, the session-to-session variability in a behavioral measure of attention covaried with the magnitude of this effect. Together, these results suggest that selective targeting of inhibitory neurons and networks is a critical mechanism for attentional modulation. PMID:27466133

Dynamics of excitatory and inhibitory networks are differentially altered by selective attention.

Science.gov (United States)

Snyder, Adam C; Morais, Michael J; Smith, Matthew A

2016-10-01

Inhibition and excitation form two fundamental modes of neuronal interaction, yet we understand relatively little about their distinct roles in service of perceptual and cognitive processes. We developed a multidimensional waveform analysis to identify fast-spiking (putative inhibitory) and regular-spiking (putative excitatory) neurons in vivo and used this method to analyze how attention affects these two cell classes in visual area V4 of the extrastriate cortex of rhesus macaques. We found that putative inhibitory neurons had both greater increases in firing rate and decreases in correlated variability with attention compared with putative excitatory neurons. Moreover, the time course of attention effects for putative inhibitory neurons more closely tracked the temporal statistics of target probability in our task. Finally, the session-to-session variability in a behavioral measure of attention covaried with the magnitude of this effect. Together, these results suggest that selective targeting of inhibitory neurons and networks is a critical mechanism for attentional modulation. Copyright © 2016 the American Physiological Society.

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons

Science.gov (United States)

Hu, Jun; Jiang, Lin; Low, Malcolm J.; Rui, Liangyou

2014-01-01

Hypothalamic POMC neurons are required for glucose and energy homeostasis. POMC neurons have a wide synaptic connection with neurons both within and outside the hypothalamus, and their activity is controlled by a balance between excitatory and inhibitory synaptic inputs. Brain glucose-sensing plays an essential role in the maintenance of normal body weight and metabolism; however, the effect of glucose on synaptic transmission in POMC neurons is largely unknown. Here we identified three types of POMC neurons (EPSC(+), EPSC(−), and EPSC(+/−)) based on their glucose-regulated spontaneous excitatory postsynaptic currents (sEPSCs), using whole-cell patch-clamp recordings. Lowering extracellular glucose decreased the frequency of sEPSCs in EPSC(+) neurons, but increased it in EPSC(−) neurons. Unlike EPSC(+) and EPSC(−) neurons, EPSC(+/−) neurons displayed a bi-phasic sEPSC response to glucoprivation. In the first phase of glucoprivation, both the frequency and the amplitude of sEPSCs decreased, whereas in the second phase, they increased progressively to the levels above the baseline values. Accordingly, lowering glucose exerted a bi-phasic effect on spontaneous action potentials in EPSC(+/−) neurons. Glucoprivation decreased firing rates in the first phase, but increased them in the second phase. These data indicate that glucose induces distinct excitatory synaptic plasticity in different subpopulations of POMC neurons. This synaptic remodeling is likely to regulate the sensitivity of the melanocortin system to neuronal and hormonal signals. PMID:25127258

IAS 41 Agriculture: Fair Value Accounting

Directory of Open Access Journals (Sweden)

Viorel Lefter

2007-05-01

Full Text Available Issuing this standard that had to be applied for the first time for the financial statements started after 1.01.2003 meant a change of direction from two points of view: on one hand, through IAS 41 was issued for the first time an extensive standard typical for this sector and, on the other hand, for the first time were included in the income statement, independently from the sales transactions, incomes from variations of the fair value of an asset. Because of this last aspect, IAS 41 can be considered an important standard, because it represents the starting point of a consistent transition from the purchase cost principle towards a fair value accounting. IASC has dedicated to the thematic field of agriculture a specific standard, because this economic branch has a great importance for the developing countries. On the other hand, IAS 41 is also applied for the agricultural activities of the enterprises from other sectors.

THE IMPACT OF METALLICITY ON THE RATE OF TYPE Ia SUPERNOVAE

Energy Technology Data Exchange (ETDEWEB)

Kistler, Matthew D. [California Institute of Technology, Mail Code 350-17, Pasadena, CA 91125 (United States); Stanek, K. Z.; Kochanek, Christopher S.; Thompson, Todd A. [Center for Cosmology and Astro-Particle Physics, Ohio State University, Columbus, OH 43210 (United States); Prieto, Jose L. [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States)

2013-06-20

The metallicity of a star strongly affects both its evolution and the properties of the stellar remnant that results from its demise. It is generally accepted that stars with initial masses below {approx}8 M{sub Sun} leave behind white dwarfs and that some sub-population of these lead to Type Ia supernovae (SNe Ia). However, it is often tacitly assumed that metallicity has no effect on the rate of SNe Ia. We propose that a consequence of the effects of metallicity is to significantly increase the SN Ia rate in lower-metallicity galaxies, in contrast to previous expectations. This is because lower-metallicity stars leave behind higher-mass white dwarfs, which should be easier to bring to explosion. We first model SN Ia rates in relation to galaxy masses and ages alone, finding that the elevation in the rate of SNe Ia in lower-mass galaxies measured by Lick Observatory SN Search is readily explained. However, we then see that models incorporating this effect of metallicity agree just as well. Using the same parameters to estimate the cosmic SN Ia rate, we again find good agreement with data up to z Almost-Equal-To 2. We suggest that this degeneracy warrants more detailed examination of host galaxy metallicities. We discuss additional implications, including for hosts of high-z SNe Ia, the SN Ia delay time distribution, super-Chandrasekhar SNe, and cosmology.

The distribution of excitatory amino acid receptors on acutely dissociated dorsal horn neurons from postnatal rats.

Science.gov (United States)

Arancio, O; Yoshimura, M; Murase, K; MacDermott, A B

1993-01-01

Excitatory amino acid receptor distribution was mapped on acutely dissociated neurons from postnatal rat spinal cord dorsal horn. N-methyl D-aspartate, quisqualate and kainate were applied to multiple locations along the somal and dendritic surfaces of voltage-clamped neurons by means of a pressure application system. To partially compensate for the decrement of response amplitude due to current loss between the site of activation on the dendrite and the recording electrode at the soma, a solution containing 0.15 M KCl was applied on the cell bodies and dendrites of some cells to estimate an empirical length constant. In the majority of the cells tested, the dendritic membrane had regions of higher sensitivity to excitatory amino acid agonists than the somatic membrane, with dendritic response amplitudes reaching more than seven times those at the cell body. A comparison of the relative changes in sensitivity between each combination of two of the three excitatory amino acid agonists along the same dendrite showed different patterns of agonist sensitivity along the dendrite in the majority of the cells. These data were obtained from dorsal horn neurons that had developed and formed synaptic connections in vivo. They demonstrate that in contrast to observations made on ventral horn neurons, receptor density for all the excitatory amino acid receptors on dorsal horn neurons, including the N-methyl-D-aspartate receptor, are generally higher on the dendrites than on the soma. Further, these results are similar to those obtained from dorsal horn neurons grown in culture.

Theoretical considerations about implementation of IAS 41 in Romania

OpenAIRE

Liliana FELEAGĂ; Niculae FELEAGĂ; Vasile RĂILEANU

2012-01-01

Although agriculture is an important part of the world economy, accounting in agriculture still has many shortcomings. The adoption of IAS 41 „Agricuture” has tried to improve this situation and increase the comparability of financial statements of entities in the agricultural sector. Although controversial, IAS 41 is the first step of a consistent transition to fair value assessment in the agricultural sector. The objective of our work is the analysis of IAS 41 and current accounting agricul...

78 FR 47237 - Proposed Amendment of Class E Airspace; Chariton, IA

Science.gov (United States)

2013-08-05

...-0255; Airspace Docket No. 13-ACE-4] Proposed Amendment of Class E Airspace; Chariton, IA AGENCY... action proposes to amend Class E airspace at Chariton, IA. Decommissioning of the Chariton non... for standard instrument approach procedures at Chariton Municipal Airport, Chariton, IA. Airspace...

Dynamical responses to external stimuli for both cases of excitatory and inhibitory synchronization in a complex neuronal network.

Science.gov (United States)

Kim, Sang-Yoon; Lim, Woochang

2017-10-01

For studying how dynamical responses to external stimuli depend on the synaptic-coupling type, we consider two types of excitatory and inhibitory synchronization (i.e., synchronization via synaptic excitation and inhibition) in complex small-world networks of excitatory regular spiking (RS) pyramidal neurons and inhibitory fast spiking (FS) interneurons. For both cases of excitatory and inhibitory synchronization, effects of synaptic couplings on dynamical responses to external time-periodic stimuli S ( t ) (applied to a fraction of neurons) are investigated by varying the driving amplitude A of S ( t ). Stimulated neurons are phase-locked to external stimuli for both cases of excitatory and inhibitory couplings. On the other hand, the stimulation effect on non-stimulated neurons depends on the type of synaptic coupling. The external stimulus S ( t ) makes a constructive effect on excitatory non-stimulated RS neurons (i.e., it causes external phase lockings in the non-stimulated sub-population), while S ( t ) makes a destructive effect on inhibitory non-stimulated FS interneurons (i.e., it breaks up original inhibitory synchronization in the non-stimulated sub-population). As results of these different effects of S ( t ), the type and degree of dynamical response (e.g., synchronization enhancement or suppression), characterized by the dynamical response factor [Formula: see text] (given by the ratio of synchronization degree in the presence and absence of stimulus), are found to vary in a distinctly different way, depending on the synaptic-coupling type. Furthermore, we also measure the matching degree between the dynamics of the two sub-populations of stimulated and non-stimulated neurons in terms of a "cross-correlation" measure [Formula: see text]. With increasing A , based on [Formula: see text], we discuss the cross-correlations between the two sub-populations, affecting the dynamical responses to S ( t ).

Theoretical uncertainties of the Type Ia supernova rate

NARCIS (Netherlands)

Claeys, J.S.W.; Pols, O.R.; Izzard, R.G.; Vink, J.; Verbunt, F.W.M.

2014-01-01

It is thought that Type Ia supernovae (SNe Ia) are explosions of carbon-oxygen white dwarfs (CO WDs). Two main evolutionary channels are proposed for the WD to reach the critical density required for a thermonuclear explosion: the single degenerate (SD) scenario, in which a CO WD accretes from a

A CATALOG OF NEAR-INFRARED SPECTRA FROM TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Marion, G. H.; Wheeler, J. C.; Robinson, E. L.; Hoeflich, P.; Gerardy, C. L.; Vacca, W. D.

2009-01-01

We present 41 near-infrared (NIR, 0.7-2.5 μm) spectra from normal Type Ia supernovae (SNe Ia) obtained at epochs ranging from 14 days before to 75 days with respect to the maximum light date in the V band. All data were obtained at the Infrared Telescope Facility using the SpeX instrument. We identify many spectral features, measure the Doppler velocities, and discuss the chemical distribution of explosion products in SNe Ia. We describe procedures for smoothing data, fitting continua, and measuring absorption features to ensure consistency for measurement and analysis. This sample provides the first opportunity to examine and compare a large number of SNe Ia in this wavelength region. NIR data are a rich source of information about explosion products whose signatures are blended or obscured in other spectral regions and NIR observations probe a greater radial depth than optical wavelengths. We analyze similarities and differences in the spectra and we show that the progressive development of spectral features for normal SNe Ia in the NIR is consistent with time. We confirm the presence of O I, Mg II, Ca II, Si II, Fe II, and Co II in these SNe. Possible identifications are made for S I, Si III, Mn II, and Fe III. There is no evidence in these data for H I, He I, C I, or C II. As the explosion products expand and cool, progressively deeper layers are revealed. Thus, a time sequence of spectra examines the chemical structure and provides direct evidence of the physical properties of SNe Ia from the outer layers to deep inside the SN. Measured Doppler velocities indicate that burning products in SNe Ia are distributed in distinct layers with no large-scale mixing. Carbon is not detected in these data, in agreement with previous results with NIR data establishing very low limits on carbon abundance in SNe Ia. Carbon burning products, O and Mg, are plentiful in the outer layers suggesting that the entire progenitor is burned in the explosion. The data provide a

75 FR 17637 - Proposed Amendment of Class E Airspace; Cherokee, IA

Science.gov (United States)

2010-04-07

...-0085; Airspace Docket No. 10-ACE-1] Proposed Amendment of Class E Airspace; Cherokee, IA AGENCY... action proposes to amend Class E airspace at Cherokee, IA. Decommissioning of the Pilot Rock non... for standard instrument approach procedures at Cherokee County Regional Airport, Cherokee, IA...

76 FR 53358 - Proposed Amendment of Class E Airspace; Centerville, IA

Science.gov (United States)

2011-08-26

...-0830; Airspace Docket No. 11-ACE-16] Proposed Amendment of Class E Airspace; Centerville, IA AGENCY... action proposes to amend Class E airspace at Centerville, IA. Decommissioning of the Centerville non... Centerville Municipal Airport, Centerville, IA. Decommissioning of the Centerville NDB and cancellation of the...

77 FR 71362 - Proposed Amendment of Class E Airspace; Decorah, IA

Science.gov (United States)

2012-11-30

...-1433; Airspace Docket No. 11-ACE-26] Proposed Amendment of Class E Airspace; Decorah, IA AGENCY... action proposes to amend Class E airspace at Decorah, IA. Decommissioning of the Decorah non-directional... instrument approach procedures at Decorah Municipal Airport, Decorah, IA. Airspace reconfiguration is...

HOST GALAXIES OF TYPE Ia SUPERNOVAE FROM THE NEARBY SUPERNOVA FACTORY

International Nuclear Information System (INIS)

Childress, M.; Aldering, G.; Aragon, C.; Bailey, S.; Fakhouri, H. K.; Hsiao, E. Y.; Kim, A. G.; Loken, S.; Antilogus, P.; Bongard, S.; Canto, A.; Cellier-Holzem, F.; Guy, J.; Baltay, C.; Buton, C.; Kerschhaggl, M.; Kowalski, M.; Chotard, N.; Copin, Y.; Gangler, E.

2013-01-01

We present photometric and spectroscopic observations of galaxies hosting Type Ia supernovae (SNe Ia) observed by the Nearby Supernova Factory. Combining Galaxy Evolution Explorer (GALEX) UV data with optical and near-infrared photometry, we employ stellar population synthesis techniques to measure SN Ia host galaxy stellar masses, star formation rates (SFRs), and reddening due to dust. We reinforce the key role of GALEX UV data in deriving accurate estimates of galaxy SFRs and dust extinction. Optical spectra of SN Ia host galaxies are fitted simultaneously for their stellar continua and emission lines fluxes, from which we derive high-precision redshifts, gas-phase metallicities, and Hα-based SFRs. With these data we show that SN Ia host galaxies present tight agreement with the fiducial galaxy mass-metallicity relation from Sloan Digital Sky Survey (SDSS) for stellar masses log(M * /M ☉ ) > 8.5 where the relation is well defined. The star formation activity of SN Ia host galaxies is consistent with a sample of comparable SDSS field galaxies, though this comparison is limited by systematic uncertainties in SFR measurements. Our analysis indicates that SN Ia host galaxies are, on average, typical representatives of normal field galaxies.

Comparison of recent SnIa datasets

International Nuclear Information System (INIS)

Sanchez, J.C. Bueno; Perivolaropoulos, L.; Nesseris, S.

2009-01-01

We rank the six latest Type Ia supernova (SnIa) datasets (Constitution (C), Union (U), ESSENCE (Davis) (E), Gold06 (G), SNLS 1yr (S) and SDSS-II (D)) in the context of the Chevalier-Polarski-Linder (CPL) parametrization w(a) = w 0 +w 1 (1−a), according to their Figure of Merit (FoM), their consistency with the cosmological constant (ΛCDM), their consistency with standard rulers (Cosmic Microwave Background (CMB) and Baryon Acoustic Oscillations (BAO)) and their mutual consistency. We find a significant improvement of the FoM (defined as the inverse area of the 95.4% parameter contour) with the number of SnIa of these datasets ((C) highest FoM, (U), (G), (D), (E), (S) lowest FoM). Standard rulers (CMB+BAO) have a better FoM by about a factor of 3, compared to the highest FoM SnIa dataset (C). We also find that the ranking sequence based on consistency with ΛCDM is identical with the corresponding ranking based on consistency with standard rulers ((S) most consistent, (D), (C), (E), (U), (G) least consistent). The ranking sequence of the datasets however changes when we consider the consistency with an expansion history corresponding to evolving dark energy (w 0 ,w 1 ) = (−1.4,2) crossing the phantom divide line w = −1 (it is practically reversed to (G), (U), (E), (S), (D), (C)). The SALT2 and MLCS2k2 fitters are also compared and some peculiar features of the SDSS-II dataset when standardized with the MLCS2k2 fitter are pointed out. Finally, we construct a statistic to estimate the internal consistency of a collection of SnIa datasets. We find that even though there is good consistency among most samples taken from the above datasets, this consistency decreases significantly when the Gold06 (G) dataset is included in the sample

Cúpulas comerciais para produção de geléia real e rainhas em colméias de abelhas Apis mellifera

Directory of Open Access Journals (Sweden)

Garcia Regina Conceição

2000-01-01

Full Text Available O objetivo do presente ensaio foi testar quatro tipos comerciais de cúpulas distintas quanto à coloração, altura, volume e diâmetro, na aceitação das larvas transferidas e na produção de geléia real e rainhas. A cúpula que apresentou maior aceitação foi a alaranjada (55,6%, seguida da amarela (37,3%, azul (36,5% e branca (26,9%. As cúpulas que apresentaram maior peso de geléia real foram branca (347,7 mg, alaranjada (312,3 mg, amarela (284,0 mg e azul (202,8 mg. O peso das larvas retiradas no momento da coleta de geléia real não apresentou diferença nas cúpulas de diferentes colorações sendo, em média, 42,0 ± 49,6 mg. O peso das rainhas recém-emergidas foi maior na cúpula branca (190,2 mg, seguida da alaranjada (181,0 mg, amarela (175,4 mg e azul (147,5 mg. O volume das realeiras não apresentou diferença nas cúpulas de diferentes colorações sendo, em média, 822,5 mm³. Com relação às cúpulas de cera, tanto a porcentagem de aceitação quanto a quantidade de geléia real produzida não apresentaram diferença entre os tratamentos. A porcentagem de aceitação nas cúpulas de cera maiores foi 18,2% e nas cúpulas menores, 12,1%. A quantidade de geléia real produzida nas cúpulas de cera menores foi 151,4 mg e nas maiores foi 137,5 mg. As cúpulas branca, alaranjada e amarela apresentaram maior quantidade de geléia real por cúpula (347,7 mg, 312,3 mg e 284,0 mg, respectivamente, entretanto, a maior quantidade total de geléia real produzida por colméia, foi obtida com as cúpulas alaranjadas (1389,40 mg. Para a produção de rainhas também sugere-se o uso das cúpulas alaranjadas

76 FR 53360 - Proposed Establishment of Class E Airspace; Stuart, IA

Science.gov (United States)

2011-08-26

...-0831; Airspace Docket No. 11-ACE-17] Proposed Establishment of Class E Airspace; Stuart, IA AGENCY... action proposes to establish Class E airspace at Stuart, IA. Controlled airspace is necessary to... surface for new standard instrument approach procedures at the City of Stuart Helistop, Stuart, IA...

76 FR 53356 - Proposed Amendment of Class E Airspace; Greenfield, IA

Science.gov (United States)

2011-08-26

...-0846; Airspace Docket No. 11-ACE-18] Proposed Amendment of Class E Airspace; Greenfield, IA AGENCY... action proposes to amend Class E airspace at Greenfield, IA. Decommissioning of the Greenfield non-directional beacon (NDB) at Greenfield Municipal Airport, Greenfield, IA, has made this action necessary for...

77 FR 50650 - Proposed Amendment of Class E Airspace; Boone, IA

Science.gov (United States)

2012-08-22

...-1432; Airspace Docket No. 11-ACE-25] Proposed Amendment of Class E Airspace; Boone, IA AGENCY: Federal... proposes to amend Class E airspace at Boone, IA. Decommissioning of the Boone non-directional beacon (NDB... instrument approach procedures at Boone Municipal Airport, Boone, IA. Airspace reconfiguration is necessary...

78 FR 48840 - Proposed Amendment of Class E Airspace; Hampton, IA

Science.gov (United States)

2013-08-12

...-0585; Airspace Docket No. 13-ACE-7] Proposed Amendment of Class E Airspace; Hampton, IA AGENCY: Federal... proposes to amend Class E airspace at Hampton, IA. Decommissioning of the Hampton non-directional beacon... for standard instrument approach procedures at Hampton Municipal Airport, Hampton, IA. A segment would...

77 FR 50647 - Proposed Amendment of Class E Airspace; Perry, IA

Science.gov (United States)

2012-08-22

...-1435; Airspace Docket No. 11-ACE-28] Proposed Amendment of Class E Airspace; Perry, IA AGENCY: Federal... proposes to amend Class E airspace at Perry, IA. Decommissioning of the Perry non-directional beacon (NDB) at Perry Municipal Airport, Perry, IA, has made reconfiguration necessary for standard instrument...

Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: Design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs

DEFF Research Database (Denmark)

Erichsen, Mette Norman; Hansen, J; Artacho Ruiz, Jose

2014-01-01

Uptake of the major excitatory neurotransmitter in the CNS, (S)-glutamate, is mediated by a family of excitatory amino acid transporters (EAAT). Previously we have explored the structure-activity relationship (SAR) of a series of EAAT1 selective inhibitors, leading to the development of the potent...... were designed, synthesized and characterized pharmacologically at EAAT1-3 in a [(3)H]-D-aspartate uptake assay. Most notably, the potent EAAT1 inhibition displayed of UCPH-101 and UCPH-102 was retained in analog 1d in which the napht-1-yl group in the 7-position of UCPH-102 has been replaced by an o...

75 FR 6592 - Proposed Amendment of Class E Airspace; Emmetsburg, IA

Science.gov (United States)

2010-02-10

...-1153; Airspace Docket No. 09-ACE-13] Proposed Amendment of Class E Airspace; Emmetsburg, IA AGENCY... action proposes to amend Class E airspace at Emmetsburg, IA. Additional controlled airspace is necessary..., Emmetsburg, IA. The FAA is taking this action to enhance the safety and management of Instrument Flight Rules...

77 FR 68683 - Amendment of Class E Airspace; Forest City, IA

Science.gov (United States)

2012-11-16

...-0654; Airspace Docket No. 12-ACE-3] Amendment of Class E Airspace; Forest City, IA AGENCY: Federal... Forest City, IA. Additional controlled airspace is necessary to accommodate new Area Navigation (RNAV... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the Forest City, IA...

77 FR 45987 - Proposed Amendment of Class E Airspace; Guthrie, IA

Science.gov (United States)

2012-08-02

...-1436; Airspace Docket No. 11-ACE-29] Proposed Amendment of Class E Airspace; Guthrie, IA AGENCY... action proposes to amend Class E airspace at Guthrie, IA. Decommissioning of the Guthrie Center non-directional radio beacon (NDB) at Guthrie County Regional Airport, Guthrie, IA, has made this action necessary...

75 FR 13668 - Amendment of Class E Airspace; Cedar Rapids, IA

Science.gov (United States)

2010-03-23

...-0916; Airspace Docket No. 09-ACE-12] Amendment of Class E Airspace; Cedar Rapids, IA AGENCY: Federal... Cedar Rapids, IA, to accommodate Area Navigation (RNAV) Standard Instrument Approach Procedures (SIAPs) at The Eastern Iowa Airport, Cedar Rapids, IA. The FAA is taking this action to enhance the safety...

76 FR 5472 - Establishment of Class E Airspace; New Hampton, IA

Science.gov (United States)

2011-02-01

...-1035; Airspace Docket No. 10-ACE-12] Establishment of Class E Airspace; New Hampton, IA AGENCY: Federal... at New Hampton, IA, to accommodate new Area Navigation (RNAV) Standard Instrument Approach Procedures (SIAP) at Mercy Medical Center Heliport, New Hampton, IA. The FAA is taking this action to enhance the...

Emergent spatial patterns of excitatory and inhibitory synaptic strengths drive somatotopic representational discontinuities and their plasticity in a computational model of primary sensory cortical area 3b

Directory of Open Access Journals (Sweden)

Kamil A. Grajski

2016-07-01

Full Text Available Mechanisms underlying the emergence and plasticity of representational discontinuities in the mammalian primary somatosensory cortical representation of the hand are investigated in a computational model. The model consists of an input lattice organized as a three-digit hand forward-connected to a lattice of cortical columns each of which contains a paired excitatory and inhibitory cell. Excitatory and inhibitory synaptic plasticity of feedforward and lateral connection weights is implemented as a simple covariance rule and competitive normalization. Receptive field properties are computed independently for excitatory and inhibitory cells and compared within and across columns. Within digit representational zones intracolumnar excitatory and inhibitory receptive field extents are concentric, single-digit, small, and unimodal. Exclusively in representational boundary-adjacent zones, intracolumnar excitatory and inhibitory receptive field properties diverge: excitatory cell receptive fields are single-digit, small, and unimodal; and the paired inhibitory cell receptive fields are bimodal, double-digit, and large. In simulated syndactyly (webbed fingers, boundary-adjacent intracolumnar receptive field properties reorganize to within-representation type; divergent properties are reacquired following syndactyly release. This study generates testable hypotheses for assessment of cortical laminar-dependent receptive field properties and plasticity within and between cortical representational zones. For computational studies, present results suggest that concurrent excitatory and inhibitory plasticity may underlie novel emergent properties.

Inhibitory neurons modulate spontaneous signaling in cultured cortical neurons: density-dependent regulation of excitatory neuronal signaling

International Nuclear Information System (INIS)

Serra, Michael; Guaraldi, Mary; Shea, Thomas B

2010-01-01

Cortical neuronal activity depends on a balance between excitatory and inhibitory influences. Culturing of neurons on multi-electrode arrays (MEAs) has provided insight into the development and maintenance of neuronal networks. Herein, we seeded MEAs with murine embryonic cortical/hippocampal neurons at different densities ( 1000 cells mm −2 ) and monitored resultant spontaneous signaling. Sparsely seeded cultures displayed a large number of bipolar, rapid, high-amplitude individual signals with no apparent temporal regularity. By contrast, densely seeded cultures instead displayed clusters of signals at regular intervals. These patterns were observed even within thinner and thicker areas of the same culture. GABAergic neurons (25% of total neurons in our cultures) mediated the differential signal patterns observed above, since addition of the inhibitory antagonist bicuculline to dense cultures and hippocampal slice cultures induced the signal pattern characteristic of sparse cultures. Sparsely seeded cultures likely lacked sufficient inhibitory neurons to modulate excitatory activity. Differential seeding of MEAs can provide a unique model for analyses of pertubation in the interaction between excitatory and inhibitory function during aging and neuropathological conditions where dysregulation of GABAergic neurons is a significant component

Diarréia por parasitas Parasites induced diarrheas

Directory of Open Access Journals (Sweden)

Maria Eugênia Farias Almeida Motta

2002-08-01

Full Text Available A diarréia é uma causa importante de morbimortalidade nos países em desenvolvimento. Os agentes etiológicos mais comuns são os vírus e as bactérias. Este artigo tem o objetivo de analisar a ocorrência de diarréia como manifestação clínica de parasitose. Discute-se quais os protozoários e os helmintos que podem causar diarréia, as bases científicas atuais que explicam os mecanismos fisiopatológicos que desencadeiam a diarréia, bem como os exames complementares e o tratamento adequado para cada parasita implicado.Diarrhea is an important cause of morbidity and mortality in developing countries. The most common etiological agents are viruses and bacteria. This article has the objective of analyzing diarrhea as a clinical symptom of parasitosis. Protozoa and helminthes that may cause diarrhea are discussed, current scientific basis clarifying the pathological and physiological mechanisms causing diarrhea as well as supplementary tests and adequate treatment for each parasite involved are focused.

The ‘grey’ assessment practice of IA screening: Prevalence, influence and applied rationale

International Nuclear Information System (INIS)

Bidstrup, Morten

2017-01-01

Research focusing on the practices surrounding screening in Impact Assessment (IA) is limited. Yet, it has been found that development proposals sometimes are adjusted through an informal dialog with IA practitioners prior to or during screening. Such practice is often referred to as ‘grey IA’ in Denmark. This article explores the prevalence, influence and applied rationale of grey IA. Through a questionnaire, data was collected from 121 IA practitioners working within the fields of environmental impact assessment and strategic environmental assessment. It was found that grey IA is a common practice, which influences the outcomes of formal screening procedures through consideration of impacts on neighbours and spatial zones of protection. Grey IA is to some extent motivated by the opportunity to save the resources required for full-scale IA, but an additional ‘green’ rationale also exists. Grey IA may influence the effectiveness of IA systems, but further research is needed before any conclusions can be made. - Highlights: • Screening procedures may function as an informal, ‘grey’ assessment. • Grey assessment is common and influences formal screening outcomes. • Grey assessment is motivated by an opportunity to cut IA costs. • Yet, an environmental, ‘green’ rationale for grey assessment also exists.

The ‘grey’ assessment practice of IA screening: Prevalence, influence and applied rationale

Energy Technology Data Exchange (ETDEWEB)

Bidstrup, Morten, E-mail: Bidstrup@plan.aau.dk

2017-01-15

Research focusing on the practices surrounding screening in Impact Assessment (IA) is limited. Yet, it has been found that development proposals sometimes are adjusted through an informal dialog with IA practitioners prior to or during screening. Such practice is often referred to as ‘grey IA’ in Denmark. This article explores the prevalence, influence and applied rationale of grey IA. Through a questionnaire, data was collected from 121 IA practitioners working within the fields of environmental impact assessment and strategic environmental assessment. It was found that grey IA is a common practice, which influences the outcomes of formal screening procedures through consideration of impacts on neighbours and spatial zones of protection. Grey IA is to some extent motivated by the opportunity to save the resources required for full-scale IA, but an additional ‘green’ rationale also exists. Grey IA may influence the effectiveness of IA systems, but further research is needed before any conclusions can be made. - Highlights: • Screening procedures may function as an informal, ‘grey’ assessment. • Grey assessment is common and influences formal screening outcomes. • Grey assessment is motivated by an opportunity to cut IA costs. • Yet, an environmental, ‘green’ rationale for grey assessment also exists.

SN 2014J at M82 - I. A middle-class Type Ia supernova by all spectroscopic metrics

Science.gov (United States)

Galbany, L.; Moreno-Raya, M. E.; Ruiz-Lapuente, P.; González Hernández, J. I.; Méndez, J.; Vallely, P.; Baron, E.; Domínguez, I.; Hamuy, M.; López-Sánchez, A. R.; Mollá, M.; Catalán, S.; Cooke, E. A.; Fariña, C.; Génova-Santos, R.; Karjalainen, R.; Lietzen, H.; McCormac, J.; Riddick, F. C.; Rubiño-Martín, J. A.; Skillen, I.; Tudor, V.; Vaduvescu, O.

2016-03-01

We present the intensive spectroscopic follow up of the Type Ia supernova (SN Ia) 2014J in the starburst galaxy M82. Twenty-seven optical spectra have been acquired from 2014 January 22 to September 1 with the Isaac Newton and William Herschel Telescopes. After correcting the observations for the recession velocity of M82 and for Milky Way and host galaxy extinction, we measured expansion velocities from spectral line blueshifts and pseudo-equivalent width of the strongest features in the spectra, which gives an idea on how elements are distributed within the ejecta. We position SN 2014J in the Benetti, Branch et al. and Wang et al. diagrams. These diagrams are based on properties of the Si II features and provide dynamical and chemical information about the SN ejecta. The nearby SN 2011fe, which showed little evidence for reddening in its host galaxy, is shown as a reference for comparisons. SN 2014J is a border-line object between the Core-normal and Broad-line groups, which corresponds to an intermediate position between low-velocity gradient and high-velocity gradient objects. SN 2014J follows the R(Si II)-Δm15 correlation, which confirms its classification as a relatively normal SN Ia. Our description of the SN Ia in terms of the evolution of the pseudo-equivalent width of various ions as well as the position in the various diagrams put this specific SN Ia into the overall sample of SN Ia.

Detection of non-aggressive stage IA lung cancer using chest computed tomography and positron emission tomography/computed tomography.

Science.gov (United States)

Shiono, Satoshi; Yanagawa, Naoki; Abiko, Masami; Sato, Toru

2014-10-01

In contrast to lung cancer with ground-glass opacity, the radiological investigation of solid lung cancer has not been well examined. The aim of this study was to explore chest computed tomography (CT) and positron emission tomography (PET)/CT findings with regard to outcomes after lung cancer surgery in order to radiologically classify clinical stage IA lung cancers by tumour aggressiveness. Three hundred and fifteen clinical stage IA patients were analysed. Four groups were defined by tumour solidity on CT and by the standardized uptake value (SUV) index on PET-CT (tumour maximum SUV/mean right liver lobe SUV). We analysed the association between radiological findings and both pathological invasiveness and postoperative outcome. Group A (n = 84) had an SUV index <1.0 and non-solid tumours, Group B (n = 24) had an SUV index <1.0 and solid tumours, Group C (n = 54) had an SUV index ≥1.0 and non-solid tumours, while Group D (n = 153) had an SUV index ≥1.0 and solid tumours. Invasive lung cancer was found in 2/84 (2.4%) patients in Group A, 1/24 (4.2%) in Group B, 13/54 (24.1%) in Group C and 58/153 (37.9%) in Group D (P < 0.01). The 5-year recurrence-free rate was 100% in Groups A and B, 90.3% in C and 65.7% in D (P < 0.01). The cancer-specific survival rate was 100% in A and B, 94.6% in C and 81.7% in D (P < 0.01). The present results suggest that preoperative PET/CT and thin-section CT findings provide important information for a selection of surgical procedures for clinical stage IA lung cancers. In clinical stage IA lung cancers displaying solid or non-solid density in thin-section findings, an SUV index <1.0 may be a better criterion for detecting non-aggressive lung cancer even in solid lung cancers. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

76 FR 53353 - Proposed Amendment of Class E Airspace; Carroll, IA

Science.gov (United States)

2011-08-26

...-0845; Airspace Docket No. 11-ACE-19] Proposed Amendment of Class E Airspace; Carroll, IA AGENCY... action proposes to amend Class E airspace at Carroll, IA. Decommissioning of the Carroll non-directional beacon (NDB) at Arthur N. Neu Airport, Carroll, IA, has made this action necessary for the safety and...

75 FR 6595 - Proposed Amendment of Class E Airspace; Mapleton, IA

Science.gov (United States)

2010-02-10

...-1155; Airspace Docket No. 09-ACE-14] Proposed Amendment of Class E Airspace; Mapleton, IA AGENCY... action proposes to amend Class E airspace at Mapleton, IA. Additional controlled airspace is necessary to..., Mapleton, IA. The FAA is taking this action to enhance the safety and management of Instrument Flight Rules...

78 FR 18798 - Amendment of Class E Airspace; West Union, IA

Science.gov (United States)

2013-03-28

...-1434; Airspace Docket No. 11-ACE-27] Amendment of Class E Airspace; West Union, IA AGENCY: Federal... West Union, IA. Decommissioning of the West Union non-directional beacon (NDB) at George L. Scott... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace for the West Union, IA...

Scholarship for Service: IA Tutorials and Workshops for Educators

National Research Council Canada - National Science Library

Irvine, Cynthia E; Falby, Naomi B

2005-01-01

... of Information Assurance (IA) and computer security. The target audience of the workshops has been 2-year college, 4-year college, and university-level educators who have responsibility for teaching curricula that are, or could be, related to IA issues...

SHOCK BREAKOUT FROM TYPE Ia SUPERNOVA

International Nuclear Information System (INIS)

Piro, Anthony L.; Chang, Philip; Weinberg, Nevin N.

2010-01-01

The mode of explosive burning in Type Ia supernovae (SNe Ia) remains an outstanding problem. It is generally thought to begin as a subsonic deflagration, but this may transition into a supersonic detonation (the delayed detonation transition, DDT). We argue that this transition leads to a breakout shock, which would provide the first unambiguous evidence that DDTs occur. Its main features are a hard X-ray flash (∼20 keV) lasting ∼10 -2 s with a total radiated energy of ∼10 40 erg, followed by a cooling tail. This creates a distinct feature in the visual light curve, which is separate from the nickel decay. This cooling tail has a maximum absolute visual magnitude of M V ∼ -9 to -10 at ∼1 day, which depends most sensitively on the white dwarf radius at the time of the DDT. As the thermal diffusion wave moves in, the composition of these surface layers may be imprinted as spectral features, which would help to discern between SN Ia progenitor models. Since this feature should accompany every SNe Ia, future deep surveys (e.g., m = 24) will see it out to a distance of ∼80 Mpc, giving a maximum rate of ∼60 yr -1 . Archival data sets can also be used to study the early rise dictated by the shock heating (at ∼20 days before maximum B-band light). A similar and slightly brighter event may also accompany core bounce during the accretion-induced collapse to a neutron star, but with a lower occurrence rate.

RATES AND DELAY TIMES OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Ruiter, Ashley J.; Belczynski, Krzysztof; Fryer, Chris

2009-01-01

We analyze the evolution of binary stars to calculate synthetic rates and delay times of the most promising Type Ia Supernovae (SNe Ia) progenitors. We present and discuss evolutionary scenarios in which a white dwarf (WD) reaches the Chandrasekhar mass and potentially explodes in a SNe Ia. We consider Double Degenerate (DDS; merger of two WDs), Single Degenerate (SDS; WD accreting from H-rich companion), and AM Canum Venaticorum (AM CVn; WD accreting from He-rich companion) scenarios. The results are presented for two different star formation histories: burst (elliptical-like galaxies) and continuous (spiral-like galaxies). It is found that delay times for the DDS in our standard model (with common envelope efficiency α CE = 1) follow a power-law distribution. For the SDS we note a wide range of delay times, while AM CVn progenitors produce a short burst of SNe Ia at early times. The DDS median delay time falls between ∼0.5 and 1 Gyr; the SDS between ∼2 and 3 Gyr; and the AM CVn between ∼0.8 and 0.6 Gyr depending on the assumed α CE . For a Milky-Way-like (MW-like) galaxy, we estimate the rates of SNe Ia arising from different progenitors as: ∼10 -4 yr -1 for the SDS and AM CVn, and ∼10 -3 yr -1 for the DDS. We point out that only the rates for two merging carbon-oxygen WDs, the only systems found in the DDS, are consistent with the observed rates for typical MW-like spirals. We also note that DDS progenitors are the dominant population in elliptical galaxies. The fact that the delay time distribution for the DDS follows a power law implies more SNe Ia (per unit mass) in young rather than in aged populations. Our results do not exclude other scenarios, but strongly indicate that the DDS is the dominant channel generating SNe Ia in spiral galaxies, at least in the framework of our adopted evolutionary models. Since it is believed that WD mergers cannot produce a thermonuclear explosion given the current understanding of accreting WDs, either the

Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1

Directory of Open Access Journals (Sweden)

Neugebauer Volker

2010-12-01

Full Text Available Abstract Neuroplasticity in the central nucleus of the amygdala (CeA, particularly its latero-capsular division (CeLC, is an important contributor to the emotional-affective aspects of pain. Previous studies showed synaptic plasticity of excitatory transmission to the CeLC in different pain models, but pain-related changes of inhibitory transmission remain to be determined. The CeLC receives convergent excitatory inputs from the parabrachial nucleus in the brainstem and from the basolateral amygdala (BLA. In addition, feedforward inhibition of CeA neurons is driven by glutamatergic projections from the BLA area to a cluster of GABAergic neurons in the intercalated cell masses (ITC. Using patch-clamp in rat brain slices we measured monosynaptic excitatory postsynaptic currents (EPSCs and polysynaptic inhibitory currents (IPSCs that were evoked by electrical stimulation in the BLA. In brain slices from arthritic rats, input-output functions of excitatory synaptic transmission were enhanced whereas inhibitory synaptic transmission was decreased compared to control slices from normal untreated rats. A non-NMDA receptor antagonist (NBQX blocked the EPSCs and reduced the IPSCs, suggesting that non-NMDA receptors mediate excitatory transmission and also contribute to glutamate-driven feed-forward inhibition of CeLC neurons. IPSCs were blocked by a GABAA receptor antagonist (bicuculline. Bicuculline increased EPSCs under normal conditions but not in slices from arthritic rats, which indicates a loss of GABAergic control of excitatory transmission. A metabotropic glutamate receptor subtype 1 (mGluR1 antagonist (LY367385 reversed both the increase of excitatory transmission and the decrease of inhibitory transmission in the arthritis pain model but had no effect on basal synaptic transmission in control slices from normal rats. The inhibitory effect of LY367385 on excitatory transmission was blocked by bicuculline suggesting the involvement of a GABAergic

75 FR 26709 - Clarke County Water Supply Project, Clarke County, IA

Science.gov (United States)

2010-05-12

... Project, Clarke County, IA AGENCY: Natural Resources Conservation Service. ACTION: Notice of intent to... Conservationist for Planning, 210 Walnut Street, Room 693, Des Moines, IA 50309-2180, telephone: 515-284- 4769... available at the Iowa NRCS Web site at http://www.ia.nrcs.usda.gov . A map of the Clarke County Water Supply...

High-resolution mapping of Rsn1, a locus controlling sensitivity of rice to a necrosis-inducing phytotoxin from Rhizoctonia solani AG1-IA

Science.gov (United States)

Rhizoctonia solani is a necrotrophic fungal pathogen that causes disease on all major crop-plant species. Anastomosis group 1-IA is the causal agent of sheath blight of rice (Oryza sativa), one of the most important rice diseases worldwide. R. solani AG-IA produces a necrosis-inducing phytotoxin a...

Enhanced excitatory input to MCH neurons during developmental period of high food intake is mediated by GABA

Science.gov (United States)

Li, Ying; van den Pol, Anthony N.

2010-01-01

In contrast to the local axons of GABA neurons of the cortex and hippocampus, lateral hypothalamic neurons containing melanin concentrating hormone (MCH) and GABA send long axons throughout the brain and play key roles in energy homeostasis and mental status. In adults, MCH neurons maintain a hyperpolarized membrane potential and most of the synaptic input is inhibitory. In contrast, we found that developing MCH neurons received substantially more excitatory synaptic input. Based on gramicidicin-perforated patch recordings in hypothalamic slices from MCH-GFP transgenic mice, we found that GABA was the primary excitatory synaptic transmitter in embryonic and neonatal ages up to postnatal day 10. Surprisingly, glutamate assumed only a minor excitatory role, if any. GABA plays a complex role in developing MCH neurons, with its actions conditionally dependent on a number of factors. GABA depolarization could lead to an increase in spikes either independently or in summation with other depolarizing stimuli, or alternately, depending on the relative timing of other depolarizing events, could lead to shunting inhibition. The developmental shift from depolarizing to hyperpolarizing occurred later in the dendrites than in the cell body. Early GABA depolarization was based on a Cl− dependent inward current. An interesting secondary depolarization in mature neurons that followed an initial hyperpolarization was based on a bicarbonate mechanism. Thus during the early developmental period when food consumption is high, MCH neurons are more depolarized than in the adult, and an increased level of excitatory synaptic input to these orexigenic cells is mediated by GABA. PMID:19955372

How is IFRS/IAS implemented in China

OpenAIRE

Wei, Fei

2007-01-01

Mastergradsoppgave i bedriftsøkonomi - Høgskolen i Bodø, 2007 The thesis investigates how IFRS/IAS is implemented in China. The main idea of the study is to find out the answers of following questions: How has the environment of Chinese accounting changed? What are the reasons for convergence with IFRS/IAS in China? What is the new finding in new accounting standards from perspective of accounting as technology? How can we understand the process of accounting institutionaliz...

Dexmedetomidine decreases inhibitory but not excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

Science.gov (United States)

Sharp, Douglas B; Wang, Xin; Mendelowitz, David

2014-07-29

Dexmedetomidine, an α2 adrenergic agonist, is a useful sedative but can also cause significant bradycardia. This decrease in heart rate may be due to decreased central sympathetic output as well as increased parasympathetic output from brainstem cardiac vagal neurons. In this study, using whole cell voltage clamp methodology, the actions of dexmedetomidine on excitatory glutamatergic and inhibitory GABAergic and glycinergic neurotransmission to parasympathetic cardiac vagal neurons in the rat nucleus ambiguus was determined. The results indicate that dexmedetomidine decreases both GABAergic and glycinergic inhibitory input to cardiac vagal neurons, with no significant effect on excitatory input. These results provide a mechanism for dexmedetomidine induced bradycardia and has implications for the management of this potentially harmful side effect. Copyright © 2014 Elsevier B.V. All rights reserved.

THE PRODUCTION RATE OF SN Ia EVENTS IN GLOBULAR CLUSTERS

International Nuclear Information System (INIS)

Washabaugh, Pearce C.; Bregman, Joel N.

2013-01-01

In globular clusters, dynamical evolution produces luminous X-ray emitting binaries at a rate about 200 times greater than in the field. If globular clusters also produce SN Ia at a high rate, it would account for many of the SN Ia production in early-type galaxies and provide insight into their formation. Here we use archival Hubble Space Telescope (HST) images of nearby galaxies that have hosted an SN Ia to examine the rate at which globular clusters produce these events. The location of the SN Ia is registered on an HST image obtained before the event or after the supernova (SN) faded. Of the 36 nearby galaxies examined, 21 had sufficiently good data to search for globular cluster hosts. None of the 21 SNe have a definite globular cluster counterpart, although there are some ambiguous cases. This places an upper limit to the enhancement rate of SN Ia production in globular clusters of about 42 at the 95% confidence level, which is an order of magnitude lower than the enhancement rate for luminous X-ray binaries. Even if all of the ambiguous cases are considered as having a globular cluster counterpart, the upper bound for the enhancement rate is 82 at the 95% confidence level, still a factor of several below that needed to account for half of the SN Ia events. Barring unforeseen selection effects, we conclude that globular clusters are not responsible for producing a significant fraction of the SN Ia events in early-type galaxies.

ON THE PROGENITORS OF SUPER-CHANDRASEKHAR MASS TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Chen Wencong; Li Xiangdong

2009-01-01

Type Ia supernovae (SNe Ia) can be used as the standard candle to determine the cosmological distances because they are thought to have a uniform fuel amount. Recent observations of several overluminous SNe Ia suggest that the white dwarf masses at supernova explosion may significantly exceed the canonical Chandrasekhar mass limit. These massive white dwarfs may be supported by rapid differential rotation. Based on a single-degenerate model and the assumption that the white dwarf would differentially rotate when the accretion rate M-dot>3 x 10 -7 M-odot yr -1 , we have calculated the evolutions of close binaries consisting of a white dwarf and a normal companion. To include the effect of rotation, we introduce an effective mass M eff for white dwarfs. For the donor stars with two different metallicities Z = 0.02 and 0.001, we present the distribution of the initial donor star masses and the orbital periods of the progenitors of super-Chandrasekhar mass SNe Ia. The calculation results indicate that, for an initial massive white dwarf of 1.2 M sun , a considerable fraction of SNe Ia may result from super-Chandrasekhar mass white dwarfs, but very massive (> 1.7 M sun ) white dwarfs are difficult to form, and none of them could be found in old populations. However, super-Chandrasekhar mass SNe Ia are very rare when the initial mass of white dwarfs is 1.0 M sun . Additionally, SNe Ia in low metallicity environment are more likely to be homogeneous.

The Implementation of IAS 16 and IAS 41 at Andrew Peller Limited

Science.gov (United States)

Lapointe-Antunes, Pascale; Moore, James

2013-01-01

This case asks students to play the role of Doug Grodeckie, Manager of Financial Reporting at Andrew Peller Limited (APL). Doug was asked to prepare a report analyzing Andrew Peller Limited's current tangible long-lived assets disclosures and making recommendations on how best to comply with International Accounting Standard (IAS) 16 Property,…

An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex

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Yonglu Tian

2018-02-01

Full Text Available Short-term memory (STM is crucial for animals to hold information for a small period of time. Persistent or recurrent neural activity, together with neural oscillations, is known to encode the STM at the cellular level. However, the coding mechanisms at the microcircuitry level remain a mystery. Here, we performed two-photon imaging on behaving mice to monitor the activity of neuronal microcircuitry. We discovered a neuronal subpopulation in the medial prefrontal cortex (mPFC that exhibited emergent properties in a context-dependent manner underlying a STM-like behavior paradigm. These neuronal subpopulations exclusively comprise excitatory neurons and mainly represent a group of neurons with stronger functional connections. Microcircuitry plasticity was maintained for minutes and was absent in an animal model of Alzheimer’s disease (AD. Thus, these results point to a functional coding mechanism that relies on the emergent behavior of a functionally defined neuronal assembly to encode STM.

A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold.

Science.gov (United States)

Marsden, Kurt C; Jain, Roshan A; Wolman, Marc A; Echeverry, Fabio A; Nelson, Jessica C; Hayer, Katharina E; Miltenberg, Ben; Pereda, Alberto E; Granato, Michael

2018-04-17

Sensory experiences dynamically modify whether animals respond to a given stimulus, but it is unclear how innate behavioral thresholds are established. Here, we identify molecular and circuit-level mechanisms underlying the innate threshold of the zebrafish startle response. From a forward genetic screen, we isolated five mutant lines with reduced innate startle thresholds. Using whole-genome sequencing, we identify the causative mutation for one line to be in the fragile X mental retardation protein (FMRP)-interacting protein cyfip2. We show that cyfip2 acts independently of FMRP and that reactivation of cyfip2 restores the baseline threshold after phenotype onset. Finally, we show that cyfip2 regulates the innate startle threshold by reducing neural activity in a small group of excitatory hindbrain interneurons. Thus, we identify a selective set of genes critical to establishing an innate behavioral threshold and uncover a circuit-level role for cyfip2 in this process. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

The Carnegie Supernova Project: Intrinsic colors of type Ia supernovae

International Nuclear Information System (INIS)

Burns, Christopher R.; Persson, S. E.; Freedman, Wendy L.; Madore, Barry F.; Stritzinger, Maximilian; Contreras, Carlos; Phillips, M. M.; Hsiao, E. Y.; Boldt, Luis; Campillay, Abdo; Castellón, Sergio; Morrell, Nidia; Salgado, Francisco; Folatelli, Gaston; Suntzeff, Nicholas B.

2014-01-01

We present an updated analysis of the intrinsic colors of Type Ia supernova (SNe Ia) using the latest data release of the Carnegie Supernova Project. We introduce a new light-curve parameter very similar to stretch that is better suited for fast-declining events, and find that these peculiar types can be seen as extensions to the population of 'normal' SNe Ia. With a larger number of objects, an updated fit to the Lira relation is presented along with evidence for a dependence on the late-time slope of the B – V light-curves with stretch and color. Using the full wavelength range from u to H band, we place constraints on the reddening law for the sample as a whole and also for individual events/hosts based solely on the observed colors. The photometric data continue to favor low values of R V , though with large variations from event to event, indicating an intrinsic distribution. We confirm the findings of other groups that there appears to be a correlation between the derived reddening law, R V , and the color excess, E(B – V), such that larger E(B – V) tends to favor lower R V . The intrinsic u-band colors show a relatively large scatter that cannot be explained by variations in R V or by the Goobar power-law for circumstellar dust, but rather is correlated with spectroscopic features of the supernova and is therefore likely due to metallicity effects.

The double-degenerate model for the progenitors of Type Ia supernovae

Science.gov (United States)

Liu, D.; Wang, B.; Han, Z.

2018-02-01

The double-degenerate (DD) model, involving the merging of massive double carbon-oxygen white dwarfs (CO WDs) driven by gravitational wave radiation, is one of the classical pathways for the formation of Type Ia supernovae (SNe Ia). Recently, it has been proposed that the WD+He subgiant channel has a significant contribution to the production of massive double WDs, in which the primary WD accumulates mass by accreting He-rich matter from an He subgiant. We evolved about 1800 CO WD+He star systems and obtained a large and dense grid for producing SNe Ia through the DD model. We then performed a series of binary population synthesis simulations for the DD model, in which the WD+He subgiant channel is calculated by interpolations in the SN Ia production grid. According to our standard model, the Galactic birth rate of SNe Ia is about 2.4 × 10- 3 yr- 1 for the WD+He subgiant channel of the DD model; the total birth rate is about 3.7 × 10- 3 yr- 1 for all channels, reproducing that of observations. Previous theoretical models still have deficit with the observed SNe Ia with delay times 8 Gyr. After considering the WD+He subgiant channel, we found that the delay time distributions are comparable with the observed results. Additionally, some recent studies proposed that the violent WD mergers are more likely to produce SNe Ia based on the DD model. We estimated that the violent mergers through the DD model may contribute to at most 16 per cent of all SNe Ia.

Consolidated Financial Statements – in IAS 27 perspective

Directory of Open Access Journals (Sweden)

Mihai Deju

2012-12-01

Full Text Available The aspects concerning the preparation and publication of the consolidated financial statements have been the subject of the settlement by the Committee for International Accounting Standards (IAS even since 1976 with the publication of IAS 3 “Consolidated financial statements”. Subsequently, the standard has been amended and revised successively, on several occasions. The latest version issued in 2008 includes changes on the accounting of interests that do not control and the loss of control on a subsidiary. The actual version also includes the subsequent amendments resulting from IFRS issued until 31st of December 2010. This paper presents the essential aspects of IAS 27 (the actual version and a practical example of how to elaborate consolidated accounts in accordance with this standard.

A Significantly off-center 56Ni Distribution for the Low-Luminosity Type Ia Supernova SN 2016brx from the 100IAS survey

Science.gov (United States)

Dong, Subo; Katz, Boaz; Kollmeier, Juna A.; Kushnir, Doron; Elias-Rosa, N.; Bose, Subhash; Morrell, Nidia; Prieto, J. L.; Chen, Ping; Kochanek, C. S.; Brandt, G. M.; Holoien, T. W.-S.; Gal-Yam, Avishay; Morales-Garoffolo, Antonia; Parker, Stuart; Phillips, M. M.; Piro, Anthony L.; Shappee, B. J.; Simon, Joshua D.; Stanek, K. Z.

2018-06-01

We present nebular-phase spectra of the Type Ia supernova (SN Ia) 2016brx, a member of the 1991bg-like subclass that lies at the faint end of the SN Ia luminosity function. Nebular spectra are available for only three other 1991bg-like SNe, and their Co line centers are all within ≲ 500 km/s of each other. In contrast, the nebular Co line center of SN 2016brx is blue-shifted by >1500 km/s compared to them and by ≈1200 km/s compared to the rest frame. This is a significant shift relative to the narrow nebular line velocity dispersion of ≲ 2000 km/s of these SNe. The large range of nebular line shifts implies that the 56Ni in the ejecta of SN 1991bg-like events is off-center by ˜1000 km/s rather than universally centrally confined as previously suggested. With the addition of SN 2016brx, the Co nebular line shapes of 1991bg-like objects appear to connect with the brighter SNe Ia that show double-peaked profiles, hinting at a continuous distribution of line profiles among SNe Ia. One class of models to produce both off-center and bi-modal 56Ni distributions is collisions of white dwarfs with unequal and equal masses.

Type Ia supernova rate studies from the SDSS-II Supernova Study

Energy Technology Data Exchange (ETDEWEB)

Dilday, Benjamin [Univ. of Chicago, IL (United States)

2008-08-01

The author presents new measurements of the type Ia SN rate from the SDSS-II Supernova Survey. The SDSS-II Supernova Survey was carried out during the Fall months (Sept.-Nov.) of 2005-2007 and discovered ~ 500 spectroscopically confirmed SNe Ia with densely sampled (once every ~ 4 days), multi-color light curves. Additionally, the SDSS-II Supernova Survey has discovered several hundred SNe Ia candidates with well-measured light curves, but without spectroscopic confirmation of type. This total, achieved in 9 months of observing, represents ~ 15-20% of the total SNe Ia discovered worldwide since 1885. The author describes some technical details of the SN Survey observations and SN search algorithms that contributed to the extremely high-yield of discovered SNe and that are important as context for the SDSS-II Supernova Survey SN Ia rate measurements.

Critical analysis of IAS 2 „Stocks”, version of 2005

Directory of Open Access Journals (Sweden)

Mircea UNTARU

2016-09-01

Full Text Available This research paper aims to achieving a comparative analysis of the two versions of IAS 2 „Stocks” (variants of 1993 and 2005. The research is part of a larger study regarding the accounting processes carried out for the acknowledgement and assessment of the company stock, and the purpose of the study is to develop a new framework methodology for the acknowledgement and assessment of stocks. The research is based on a series of work hypotheses: (I1 IAS 2 variant of 1993 needs to be reviewed according to the regulations and normatives in force; (I2 the necessity to review IAS variant of 1993 derives from the critics raised by the regulating authorities for stock and shares, by the professional accountants and by other interested parties, with regard to the reduction or elimination of alternatives, redundancies and conflicts from standards, and the solving of convergence issues; (I3 the 2005 variant of IAS 2 is the result of a limited reviewing of the 1993 variant of IAS 2, and needs to be further modified.

A problem with the analysis of type Ia supernovae

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Crawford David F.

2017-12-01

Full Text Available Type Ia supernovae have light curves that have widths and magnitudes that can be used for testing cosmologies and they provide one of the few direct measurements of time dilation. It is shown that the standard analysis that calibrates the light curve against a rest-frame average (such as SALT2 removes all the cosmological information from the calibrated light curves. Consequently type Ia supernovae calibrated with these methods cannot be used to investigate cosmology. The major evidence that supports the hypothesis of a static universe is that the measurements of the widths of the rawlight curves of type Ia supernovae do not show any time dilation. The intrinsicwavelength dependence shown by the SALT2 calibration templates is also consistent with no time dilation. Using a static cosmological model the peak absolute magnitudes of raw type Ia supernovae observations are also independent of redshift. These results support the hypothesis of a static universe.

Molecular profiling identifies prognostic markers of stage IA lung adenocarcinoma.

Science.gov (United States)

Zhang, Jie; Shao, Jinchen; Zhu, Lei; Zhao, Ruiying; Xing, Jie; Wang, Jun; Guo, Xiaohui; Tu, Shichun; Han, Baohui; Yu, Keke

2017-09-26

We previously showed that different pathologic subtypes were associated with different prognostic values in patients with stage IA lung adenocarcinoma (AC). We hypothesize that differential gene expression profiles of different subtypes may be valuable factors for prognosis in stage IA lung adenocarcinoma. We performed microarray gene expression profiling on tumor tissues micro-dissected from patients with acinar and solid predominant subtypes of stage IA lung adenocarcinoma. These patients had undergone a lobectomy and mediastinal lymph node dissection at the Shanghai Chest Hospital, Shanghai, China in 2012. No patient had preoperative treatment. We performed the Gene Set Enrichment Analysis (GSEA) analysis to look for gene expression signatures associated with tumor subtypes. The histologic subtypes of all patients were classified according to the 2015 WHO lung Adenocarcinoma classification. We found that patients with the solid predominant subtype are enriched for genes involved in RNA polymerase activity as well as inactivation of the p53 pathway. Further, we identified a list of genes that may serve as prognostic markers for stage IA lung adenocarcinoma. Validation in the TCGA database shows that these genes are correlated with survival, suggesting that they are novel prognostic factors for stage IA lung adenocarcinoma. In conclusion, we have uncovered novel prognostic factors for stage IA lung adenocarcinoma using gene expression profiling in combination with histopathology subtyping.

Gonorréia Gonorrhea

Directory of Open Access Journals (Sweden)

Gerson Oliveira Penna

2000-10-01

Full Text Available A gonorréia é uma infecção bacteriana freqüente, causada pela Neisseria gonorrhoeae, um diplococo Gram-negativo de transmissão quase que exclusiva através de contato sexual ou perinatal. Primariamente afeta membranas mucosas do trato genital inferior, e mais raramente, as mucosas do reto, orofaringe e conjuntiva. A infecção genital ascendente na mulher leva a uma complicação séria, a salpingite aguda, uma das principais causas de infertilidade feminina. A partir dos anos 90, deu-se início a um novo tempo no que se refere a descobertas sobre a patogenia da gonorréia e seu agente etiológico. O controle da gonorréia tem sido difícil na maioria das populações, e essa permanece um exemplo da influência que os fatores sociais, comportamentais e demográficos exercem na epidemiologia de uma doença infecciosa. O manejo da gonorréia e de outras doenças sexualmente transmissíveis requer tanto o tratamento do paciente e de seu parceiro sexual como medidas de saúde pública para interromper a transmissão da infecção e evitar complicações a longo prazo.Gonorrhea is a common bacterial infection caused by Neisseria gonorrhoeae, a Gram-negative diplococcus that is transmitted almost exclusively by sexual contact or perinatally. It primarily affects the mucous membranes of the lower genital tract and less frequently those of the rectum, oropharynx, and conjunctivae. Ascending genital infection in women leads to the predominant complication, acute salpingitis, one of the most common causes of female infertility in the world. Since the 1990s, a remarkable surge of information ensued regarding the pathogenesis of gonorrhea and its agent. Gonorrohea has proven difficult to control in most populations and remains a prime example of the influence that social, behavioral, and demographic factors can have on the epidemiology of an infectious disease. The management of gonorrhea and other sexually transmitted infections requires both

Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives

DEFF Research Database (Denmark)

Achenbach, P; Bonifacio, E; Williams, A J K

2008-01-01

-positive participants (median age 12.1 years; 57% male), 113 developed diabetes (5 year cumulative risk 56%), and 148 were also GADA-positive and IAA-positive (4Ab-positive). IA2betaA were detected in 137 (65%) ICA/IA2A-positive participants and were associated with an increased 5 year diabetes risk (IA2beta......A-positive 65 vs 39% in IA2betaA-negative, p=0.0002). The effect was most marked in 4Ab-positive relatives (72% vs 52%, p=0.003). Metabolic testing further refined risk assessment. Among 101 4Ab-positive relatives with IA2betaA, the 5 year risk was 94% in those with a low FPIR (vs 50% in those with a normal...... FPIR, p4Ab/IA2betaA-positive participants with a low FPIR was 1.5 years. Multivariate analysis confirmed IA2betaA status, antibody number, young...

HISTÓRIA DAS IDÉIAS PEDAGÓGICAS NO BRASIL

OpenAIRE

Aline Perazzoli; Maristela Ferreira da Rocha; Sandino Hoff

2015-01-01

A interrogação sobre a história da educação no Brasil, as idéias educacionais componentes e o lugar a ela conferida na pesquisa e no ensino universitário constitui-se no tema central do livro História das idéias Pedagógicas no Brasil, elaborado a partir dos resultados da investigação conduzida pelo autor com Bolsa de Produtividade em Pesquisa do CNPq. Cobre o conjunto de idéias pedagógicas no Brasil desde 1549 até nossos dias. O professor Saviani é formado em Filosofia pela PUC − SP, é dou...

Polarisation Spectral Synthesis For Type Ia Supernova Explosion Models

Science.gov (United States)

Bulla, Mattia

2017-02-01

Despite their relevance across a broad range of astrophysical research topics, Type Ia supernova explosions are still poorly understood and answers to the questions of when, why and how these events are triggered remain unclear. In this respect, polarisation offers a unique opportunity to discriminate between the variety of possible scenarios. The observational evidence that Type Ia supernovae are associated with rather low polarisation signals (smaller than a few per cent) places strong constraints for models and calls for modest asphericities in the progenitor system and/or explosion mechanism.The goal of this thesis is to assess the validity of contemporary Type Ia supernova explosion models by testing whether their predicted polarisation signatures can account for the small signals usually observed. To this end, we have implemented and tested an innovative Monte Carlo scheme in the radiative transfer code artis. Compared to previous Monte Carlo approaches, this technique produces synthetic observables (light curves, flux and polarisation spectra) with a substantial reduction in the Monte Carlo noise and therefore in the required computing time. This improvement is particularly crucial for our study as we aim to extract very weak polarisation signals, comparable to those detected in Type Ia supernovae. We have also demonstrated the applicability of this method to other classes of supernovae via a preliminary study of the first spectropolarimetry observations of superluminous supernovae.Using this scheme, we have calculated synthetic spectropolarimetry for three multi-dimensional explosion models recently proposed as promising candidates to explain Type Ia supernovae. Our findings highlight the power of spectropolarimetry in testing and discriminating between different scenarios. While all the three models predict light curves and flux spectra that are similar to each others and reproduce those observed in Type Ia supernovae comparably well, polarisation does

77 FR 49399 - Proposed Amendment of Class E Airspace; Forest City, IA

Science.gov (United States)

2012-08-16

...-0654; Airspace Docket No. 12-ACE-3] Proposed Amendment of Class E Airspace; Forest City, IA AGENCY... action proposes to amend Class E airspace at Forest City, IA. Additional controlled airspace is necessary... accommodate new standard instrument approach procedures at Forest City Municipal Airport, Forest City, IA. The...

77 FR 71361 - Proposed Amendment of Class E Airspace; West Union, IA

Science.gov (United States)

2012-11-30

...-1434; Airspace Docket No. 11-ACE-27] Proposed Amendment of Class E Airspace; West Union, IA AGENCY... action proposes to amend Class E airspace at West Union, IA. Decommissioning of the West Union non... instrument approach procedures at George L. Scott Municipal Airport, West Union, IA. Airspace reconfiguration...

75 FR 68558 - Proposed Establishment of Class E Airspace; New Hampton, IA

Science.gov (United States)

2010-11-08

...-1035; Airspace Docket No. 10-ACE-12] Proposed Establishment of Class E Airspace; New Hampton, IA AGENCY... action proposes to establish Class E airspace at New Hampton, IA, to accommodate new Standard Instrument... Mercy Medical Center Heliport, New Hampton, IA. Controlled airspace is needed for the safety and...

Binary Paths to Type Ia Supernovae Explosions: the Highlights

Science.gov (United States)

Ferrario, Lilia

2013-01-01

This symposium was focused on the hunt for the progenitors of Type Ia supernovae (SNe Ia). Is there a main channel for the production of SNe Ia? If so, are these elusive progenitors single degenerate or double degenerate systems? Although most participants seemed to favor the single degenerate channel, there was no general agreement on the type of binary system at play. An observational puzzle that was highlighted was the apparent paucity of supersoft sources in our Galaxy and also in external galaxies. The single degenerate channel (and as it was pointed out, quite possibly also the double degenerate channel) requires the binary system to pass through a phase of steady nuclear burning. However, the observed number of supersoft sources falls short by a factor of up to 100 in explaining the estimated birth rates of SNe Ia. Thus, are these supersoft sources somehow hidden away and radiating at different wavelengths, or are we missing some important pieces of this puzzle that may lead to the elimination of a certain class of progenitor? Another unanswered question concerns the dependence of SNe Ia luminosities on the age of their host galaxy. Several hypotheses were put forward, but none was singled out as the most likely explanation. It is fair to say that at the end of the symposium the definitive answer to the vexed progenitor question remained well and truly wide open.

Patterned sensory nerve stimulation enhances the reactivity of spinal Ia inhibitory interneurons.

Science.gov (United States)

Kubota, Shinji; Hirano, Masato; Morishita, Takuya; Uehara, Kazumasa; Funase, Kozo

2015-03-25

Patterned sensory nerve stimulation has been shown to induce plastic changes in the reciprocal Ia inhibitory circuit. However, the mechanisms underlying these changes have not yet been elucidated in detail. The aim of the present study was to determine whether the reactivity of Ia inhibitory interneurons could be altered by patterned sensory nerve stimulation. The degree of reciprocal Ia inhibition, the conditioning effects of transcranial magnetic stimulation (TMS) on the soleus (SOL) muscle H-reflex, and the ratio of the maximum H-reflex amplitude versus maximum M-wave (H(max)/M(max)) were examined in 10 healthy individuals. Patterned electrical nerve stimulation was applied to the common peroneal nerve every 1 s (100 Hz-5 train) at the motor threshold intensity of tibialis anterior muscle to induce activity changes in the reciprocal Ia inhibitory circuit. Reciprocal Ia inhibition, the TMS-conditioned H-reflex amplitude, and H(max)/M(max) were recorded before, immediately after, and 15 min after the electrical stimulation. The patterned electrical nerve stimulation significantly increased the degree of reciprocal Ia inhibition and decreased the amplitude of the TMS-conditioned H-reflex in the short-latency inhibition phase, which was presumably mediated by Ia inhibitory interneurons. However, it had no effect on H(max)/M(max). Our results indicated that patterned sensory nerve stimulation could modulate the activity of Ia inhibitory interneurons, and this change may have been caused by the synaptic modification of Ia inhibitory interneuron terminals. These results may lead to a clearer understanding of the spinal cord synaptic plasticity produced by repetitive sensory inputs. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

X-RAY AND GAMMA-RAY FLASHES FROM TYPE Ia SUPERNOVAE?

International Nuclear Information System (INIS)

Hoeflich, Peter; Schaefer, Bradley E.

2009-01-01

We investigate two potential mechanisms that will produce X-ray and γ-ray flashes from Type Ia supernovae (SN-Ia). The first mechanism is the breakout of the thermonuclear burning front as it reaches the surface of the white dwarf (WD). The second mechanism is the interaction of the rapidly expanding envelope with material within an accretion disk in the progenitor system. Our study is based on the delayed detonation scenario because this can account for the majority of light curves, spectra, and statistical properties of 'Branch-normal' SN-Ia. Based on detailed radiation-hydro calculations which include nuclear networks, we find that both mechanisms produce brief flashes of high-energy radiation with peak luminosities of 10 48 -10 50 erg s -1 . The breakout from the WD surface produces flashes with a rapid exponential decay by 3-4 orders of magnitude on timescales of a few tenths of a second and with most of the radiation in the X-ray and soft γ-ray range. The shocks produced in gases in and around the binary will produce flashes with a characteristic duration of a few seconds with most of the radiation coming out as X-rays and γ-rays. In both mechanisms, we expect a fast rise and slow decline and, after the peak, an evolution from hard to softer radiation due to adiabatic expansion. In many cases, flashes from both mechanisms will be superposed. The X- and γ-ray visibility of an SN-Ia will depend strongly on self-absorption within the progenitor system, specifically on the properties of the accretion disk and its orientation toward the observer. Such X-ray and γ-ray flashes could be detected as triggered events by gamma-ray burst (GRB) detectors on satellites, with events in current GRB catalogs. We have searched through the GRB catalogs (for the BATSE, HETE, and Swift experiments) for GRBs that occur at the extrapolated time of explosion and in the correct direction for known Type Ia supernovae with radial velocity of less than 3000 km s -1 . For the Burst

THE RISE TIME OF NORMAL AND SUBLUMINOUS TYPE Ia SUPERNOVAE

Energy Technology Data Exchange (ETDEWEB)

Gonzalez-Gaitan, S.; Perrett, K.; Carlberg, R. [Department of Astronomy and Astrophysics, University of Toronto, 50 St. george Street, Toronto, ON M5S 3H4 (Canada); Conley, A. [Center for Astrophysics and Space Astronomy, University of Colorado, 593 UCB, Boulder, CO 80309-0593 (United States); Bianco, F. B.; Howell, D. A.; Graham, M. L. [Department of Physics, University of California, Santa Barbara, Broida Hall, Mail Code 9530, Santa Barbara, CA 93106-9530 (United States); Sullivan, M.; Hook, I. M. [Department of Physics (Astrophysics), University of Oxford, DWB, Keble Road, Oxford, OX1 3RH (United Kingdom); Astier, P.; Balland, C.; Fourmanoit, N.; Guy, J.; Hardin, D.; Pain, R. [LPNHE, Universite Pierre et Marie Curie Paris 6, Universite Paris Diderot Paris 7, CNRS-IN2P3, 4 Place Jussieu, 75252 Paris Cedex 05 (France); Balam, D. [Dominion Astrophysical Observatory, Herzberg Institute of Astrophysics, 5071 West Saanich Road, Victoria, BC V9E 2E7 (Canada); Basa, S. [Laboratoire d' Astrophysique de Marseille, Pole de l' Etoile Site de Chateau-Gombert, 38, rue Frederic Joliot-Curie, 13388 Marseille cedex 13 (France); Fouchez, D. [CPPM, CNRS-IN2P3 and University Aix Marseille II, Case 907, 13288 Marseille cedex 9 (France); Lidman, C. [Australian Astronomical Observatory, P.O. Box 296, Epping, NSW 1710 (Australia); Palanque-Delabrouille, N., E-mail: gonzalez@astro.utoronto.ca [DSM/IRFU/SPP, CEA-Saclay, F-91191 Gif-sur-Yvette (France); and others

2012-01-20

We calculate the average stretch-corrected rise time of Type Ia supernovae (SNe Ia) in the Supernova Legacy Survey. We use the aggregate light curves of spectroscopic and photometrically identified SNe Ia to fit the rising part of the light curve with a simple quadratic model. We obtain a light curve shape corrected, i.e., stretch-corrected, fiducial rise time of 17.02{sup +0.18}{sub -0.28} (stat) days. The measured rise time differs from an earlier finding by the SNLS (Conley et al.) due to the use of different SN Ia templates. We compare it to nearby samples using the same methods and find no evolution in the early part of the light curve of SNe Ia up to z = 1. We search for variations among different populations, particularly subluminous objects, by dividing the sample in stretch. Bright and slow decliners (s > 1.0) have consistent stretch-corrected rise times compared to fainter and faster decliners (0.8 < s {<=} 1.0); they are shorter by 0.57{sup +0.47}{sub -0.50} (stat) days. Subluminous SNe Ia (here defined as objects with s {<=} 0.8), although less constrained, are also consistent, with a rise time of 18.03{sup +0.81}{sub -1.37} (stat) days. We study several systematic biases and find that the use of different fiducial templates may affect the average rise time but not the intrinsic differences between populations. Based on our results, we estimate that subluminous SNe Ia are powered by 0.05-0.35 M{sub Sun} of {sup 56}Ni synthesized in the explosion. Our conclusions are the same for the single-stretch and two-stretch parameterizations of the light curve.

THE ABSENCE OF EX-COMPANIONS IN TYPE Ia SUPERNOVA REMNANTS

Energy Technology Data Exchange (ETDEWEB)

Di Stefano, R. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Kilic, Mukremin, E-mail: rd@cfa.harvard.edu, E-mail: kilic@ou.edu [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, 440 West Brooks Street, Norman, OK 73019 (United States)

2012-11-01

Type Ia supernovae (SNe Ia) play important roles in our study of the expansion and acceleration of the universe, but because we do not know the exact nature or natures of the progenitors, there is a systematic uncertainty that must be resolved if SNe Ia are to become more precise cosmic probes. No progenitor system has ever been identified either in the pre- or post-explosion images of a Ia event. There have been recent claims for and against the detection of ex-companion stars in several SNe Ia remnants. These studies, however, usually ignore the angular momentum gain of the progenitor white dwarf (WD), which leads to a spin-up phase and a subsequent spin-down phase before explosion. For spin-down timescales greater than 10{sup 5} years, the donor star could be too dim to detect by the time of explosion. Here we revisit the current limits on ex-companion stars to SNR 0509-67.5, a 400-year-old remnant in the Large Magellanic Cloud. If the effects of possible angular momentum gain on the WD are included, a wide range of single-degenerate progenitor models are allowed for this remnant. We demonstrate that the current absence of evidence for ex-companion stars in this remnant, as well as other SNe Ia remnants, does not necessarily provide the evidence of absence for ex-companions. We discuss potential ways to identify such ex-companion stars through deep imaging observations.

THE ABSENCE OF EX-COMPANIONS IN TYPE Ia SUPERNOVA REMNANTS

International Nuclear Information System (INIS)

Di Stefano, R.; Kilic, Mukremin

2012-01-01

Type Ia supernovae (SNe Ia) play important roles in our study of the expansion and acceleration of the universe, but because we do not know the exact nature or natures of the progenitors, there is a systematic uncertainty that must be resolved if SNe Ia are to become more precise cosmic probes. No progenitor system has ever been identified either in the pre- or post-explosion images of a Ia event. There have been recent claims for and against the detection of ex-companion stars in several SNe Ia remnants. These studies, however, usually ignore the angular momentum gain of the progenitor white dwarf (WD), which leads to a spin-up phase and a subsequent spin-down phase before explosion. For spin-down timescales greater than 10 5 years, the donor star could be too dim to detect by the time of explosion. Here we revisit the current limits on ex-companion stars to SNR 0509-67.5, a 400-year-old remnant in the Large Magellanic Cloud. If the effects of possible angular momentum gain on the WD are included, a wide range of single-degenerate progenitor models are allowed for this remnant. We demonstrate that the current absence of evidence for ex-companion stars in this remnant, as well as other SNe Ia remnants, does not necessarily provide the evidence of absence for ex-companions. We discuss potential ways to identify such ex-companion stars through deep imaging observations.

Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons.

Science.gov (United States)

Li, Ying; Xu, Youfen; van den Pol, Anthony N

2013-03-01

In mature neurons, GABA is the primary inhibitory neurotransmitter. In contrast, in developing neurons, GABA exerts excitatory actions, and in some neurons GABA-mediated excitatory synaptic activity is more prevalent than glutamate-mediated excitation. Hypothalamic neuropeptides that modulate cognitive arousal and energy homeostasis, hypocretin/orexin and neuropeptide Y (NPY), evoked reversed effects on synaptic actions that were dependent on presynaptic GABA release onto melanin-concentrating hormone (MCH) neurons. MCH neurons were identified by selective green fluorescent protein (GFP) expression in transgenic mice. In adults, hypocretin increased GABA release leading to reduced excitation. In contrast, in the developing brain as studied here with analysis of miniature excitatory postsynaptic currents, paired-pulse ratios, and evoked potentials, hypocretin acted presynaptically to enhance the excitatory actions of GABA. The ability of hypocretin to enhance GABA release increases inhibition in adult neurons but paradoxically enhances excitation in developing MCH neurons. In contrast, NPY attenuation of GABA release reduced inhibition in mature neurons but enhanced inhibition during development by attenuating GABA excitation. Both hypocretin and NPY also evoked direct actions on developing MCH neurons. Hypocretin excited MCH cells by activating a sodium-calcium exchanger and by reducing potassium currents; NPY reduced activity by increasing an inwardly rectifying potassium current. These data for the first time show that both hypocretin and NPY receptors are functional presynaptically during early postnatal hypothalamic development and that both neuropeptides modulate GABA actions during development with a valence of enhanced excitation or inhibition opposite to that of the adult state, potentially allowing neuropeptide modulation of use-dependent synapse stabilization.

Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell

Directory of Open Access Journals (Sweden)

Regina A. Mangieri

2017-08-01

Full Text Available Anaplastic lymphoma kinase (ALK is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD. Ethanol induces adaptations in glutamatergic synapses onto nucleus accumbens shell (NAcSh medium spiny neurons (MSNs, and putative targets for treating AUD may be validated for further development by assessing how their manipulation modulates accumbal glutamatergic synaptic transmission and plasticity. Here, we report that Alk knockout (AlkKO mice consumed greater doses of ethanol, relative to wild-type (AlkWT mice, in an operant self-administration model. Using ex vivo electrophysiology to examine excitatory synaptic transmission and plasticity at NAcSh MSNs that express dopamine D1 receptors (D1MSNs, we found that the amplitude of spontaneous excitatory post-synaptic currents (EPSCs in NAcSh D1MSNs was elevated in AlkKO mice and in the presence of an ALK inhibitor, TAE684. Furthermore, when ALK was absent or inhibited, glutamatergic synaptic plasticity – long-term depression of evoked EPSCs – in D1MSNs was attenuated. Thus, loss of ALK activity in mice is associated with elevated ethanol consumption and enhanced excitatory transmission in NAcSh D1MSNs. These findings add to the mounting evidence of a relationship between excitatory synaptic transmission onto NAcSh D1MSNs and ethanol consumption, point toward ALK as one important molecular mediator of this interaction, and further validate ALK as a target for therapeutic intervention in the treatment of AUD.

ON THE RATES OF TYPE Ia SUPERNOVAE IN DWARF AND GIANT HOSTS WITH ROTSE-IIIb

International Nuclear Information System (INIS)

Quimby, Robert M.; Yuan Fang; Akerlof, Carl; Wheeler, J. Craig; Warren, Michael S.

2012-01-01

We present a sample of 23 spectroscopically confirmed Type Ia supernovae (SNe Ia) that were discovered in the background of galaxy clusters targeted by ROTSE-IIIb and use up to 18 of these to determine the local (z-bar 0.05) volumetric rate. Since our survey is flux limited and thus biased against fainter objects, the pseudo-absolute magnitude distribution (pAMD) of SNe Ia in a given volume is an important concern, especially the relative frequency of high- to low-luminosity SNe Ia. We find that the pAMD derived from the volume-limited Lick Observatory Supernova Search (LOSS) sample is incompatible with the distribution of SNe Ia in a volume-limited (z B > –16) galaxies, whereas only 1 out of 79 nearby SDSS-II SNe Ia have such faint hosts. It is possible that previous works have undercounted either low-luminosity SNe Ia, SNe Ia in low-luminosity hosts, or peculiar SNe Ia (sometimes explicitly), and the total SNe Ia rate may be higher than the canonical value.

The Carnegie Supernova Project: Intrinsic colors of type Ia supernovae

Energy Technology Data Exchange (ETDEWEB)

Burns, Christopher R.; Persson, S. E.; Freedman, Wendy L.; Madore, Barry F. [Observatories of the Carnegie Institution for Science, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Stritzinger, Maximilian; Contreras, Carlos [Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark); Phillips, M. M.; Hsiao, E. Y.; Boldt, Luis; Campillay, Abdo; Castellón, Sergio; Morrell, Nidia; Salgado, Francisco [Carnegie Institution of Washington, Las Campanas Observatory, Colina El Pino, Casilla 601 (Chile); Folatelli, Gaston [Kavli Institute for the Physics and Mathematics of the Universe, Todai Institutes for Advanced Study, the University of Tokyo, 277-8583 Kashiwa (Japan); Suntzeff, Nicholas B. [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Texas A and M University, Department of Physics and Astronomy, College Station, TX 77843 (United States)

2014-07-01

We present an updated analysis of the intrinsic colors of Type Ia supernova (SNe Ia) using the latest data release of the Carnegie Supernova Project. We introduce a new light-curve parameter very similar to stretch that is better suited for fast-declining events, and find that these peculiar types can be seen as extensions to the population of 'normal' SNe Ia. With a larger number of objects, an updated fit to the Lira relation is presented along with evidence for a dependence on the late-time slope of the B – V light-curves with stretch and color. Using the full wavelength range from u to H band, we place constraints on the reddening law for the sample as a whole and also for individual events/hosts based solely on the observed colors. The photometric data continue to favor low values of R{sub V} , though with large variations from event to event, indicating an intrinsic distribution. We confirm the findings of other groups that there appears to be a correlation between the derived reddening law, R{sub V} , and the color excess, E(B – V), such that larger E(B – V) tends to favor lower R{sub V} . The intrinsic u-band colors show a relatively large scatter that cannot be explained by variations in R{sub V} or by the Goobar power-law for circumstellar dust, but rather is correlated with spectroscopic features of the supernova and is therefore likely due to metallicity effects.

Treatment outcomes using CBT-IA with Internet-addicted patients.

Science.gov (United States)

Young, Kimberly S

2013-12-01

Internet Gaming Disorder, a subtype of Internet Addiction, is now classified in Section 3 of the DSM-5. Cognitive behavioral therapy (CBT) has been suggested in treating Internet addiction as this modality has been shown to be an effective treatment for similar impulse control disorders. Given the daily and necessary use of the Internet and technology in general compared to other compulsive syndromes, a specialized form of CBT has been developed called Cognitive-Behavioral Therapy for Internet Addiction (CBT-IA). CBT-IA is a comprehensive three phase approach that includes behavior modification to control compulsive Internet use, cognitive restructuring to identify, challenge, and modify cognitive distortions that lead to addictive use, and harm reduction techniques to address and treat co-morbid issues associated with the disorder. As the first model of its kind, this study examines 128 clients to measure treatment outcomes using CBT-IA. Clients were evaluated using the Internet Addiction Test (IAT) to classify subjects and were administered twelve weekly sessions of CBT-IA. Treatment outcomes were measured at the end of the twelve weeks, one-month, three months and at six month post-treatment. RESULTS showed that over 95% of clients were able to manage symptoms at the end of the twelve weeks and 78% sustained recovery six months following treatment. RESULTS found that CBT-IA was effective at ameliorating symptoms associated with Internet addiction after twelve weekly sessions and consistently over one-month, three months, and six months after therapy. Further research implications such as investigating long-term outcome effects of the model with larger client populations and treatment differences among the subtypes of Internet addiction or with other cultural populations using CBT-IA are discussed.

TYPE Ia SUPERNOVA COLORS AND EJECTA VELOCITIES: HIERARCHICAL BAYESIAN REGRESSION WITH NON-GAUSSIAN DISTRIBUTIONS

International Nuclear Information System (INIS)

Mandel, Kaisey S.; Kirshner, Robert P.; Foley, Ryan J.

2014-01-01

We investigate the statistical dependence of the peak intrinsic colors of Type Ia supernovae (SNe Ia) on their expansion velocities at maximum light, measured from the Si II λ6355 spectral feature. We construct a new hierarchical Bayesian regression model, accounting for the random effects of intrinsic scatter, measurement error, and reddening by host galaxy dust, and implement a Gibbs sampler and deviance information criteria to estimate the correlation. The method is applied to the apparent colors from BVRI light curves and Si II velocity data for 79 nearby SNe Ia. The apparent color distributions of high-velocity (HV) and normal velocity (NV) supernovae exhibit significant discrepancies for B – V and B – R, but not other colors. Hence, they are likely due to intrinsic color differences originating in the B band, rather than dust reddening. The mean intrinsic B – V and B – R color differences between HV and NV groups are 0.06 ± 0.02 and 0.09 ± 0.02 mag, respectively. A linear model finds significant slopes of –0.021 ± 0.006 and –0.030 ± 0.009 mag (10 3 km s –1 ) –1 for intrinsic B – V and B – R colors versus velocity, respectively. Because the ejecta velocity distribution is skewed toward high velocities, these effects imply non-Gaussian intrinsic color distributions with skewness up to +0.3. Accounting for the intrinsic-color-velocity correlation results in corrections to A V extinction estimates as large as –0.12 mag for HV SNe Ia and +0.06 mag for NV events. Velocity measurements from SN Ia spectra have the potential to diminish systematic errors from the confounding of intrinsic colors and dust reddening affecting supernova distances

Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1.

Science.gov (United States)

Park, Kellie A; Ribic, Adema; Laage Gaupp, Fabian M; Coman, Daniel; Huang, Yuegao; Dulla, Chris G; Hyder, Fahmeed; Biederer, Thomas

2016-07-13

Select adhesion proteins control the development of synapses and modulate their structural and functional properties. Despite these important roles, the extent to which different synapse-organizing mechanisms act across brain regions to establish connectivity and regulate network properties is incompletely understood. Further, their functional roles in different neuronal populations remain to be defined. Here, we applied diffusion tensor imaging (DTI), a modality of magnetic resonance imaging (MRI), to map connectivity changes in knock-out (KO) mice lacking the synaptogenic cell adhesion protein SynCAM 1. This identified reduced fractional anisotropy in the hippocampal CA3 area in absence of SynCAM 1. In agreement, mossy fiber refinement in CA3 was impaired in SynCAM 1 KO mice. Mossy fibers make excitatory inputs onto postsynaptic specializations of CA3 pyramidal neurons termed thorny excrescences and these structures were smaller in the absence of SynCAM 1. However, the most prevalent targets of mossy fibers are GABAergic interneurons and SynCAM 1 loss unexpectedly reduced the number of excitatory terminals onto parvalbumin (PV)-positive interneurons in CA3. SynCAM 1 KO mice additionally exhibited lower postsynaptic GluA1 expression in these PV-positive interneurons. These synaptic imbalances in SynCAM 1 KO mice resulted in CA3 disinhibition, in agreement with reduced feedforward inhibition in this network in the absence of SynCAM 1-dependent excitatory drive onto interneurons. In turn, mice lacking SynCAM 1 were impaired in memory tasks involving CA3. Our results support that SynCAM 1 modulates excitatory mossy fiber inputs onto both interneurons and principal neurons in the hippocampal CA3 area to balance network excitability. This study advances our understanding of synapse-organizing mechanisms on two levels. First, the data support that synaptogenic proteins guide connectivity and can function in distinct brain regions even if they are expressed broadly

Adiponectin levels correlate with the severity of hypertriglyceridaemia in glycogen storage disease Ia

NARCIS (Netherlands)

Bandsma, R. H. J.; Smit, G. P. A.; Reijngoud, D. -J.; Kuipers, F.

2009-01-01

Glycogen storage disease type Ia (GSD Ia) is characterized by severe hypercholesterolaemia and hypertriglyceridaemia. Little is known about the aetiology of the hyperlipidaemia in GSD Ia. Adipokines play an important regulatory role in lipid metabolism. We investigated whether adipokine

Measurement of insulin and C-peptide excitatory test levels in gestational diabetes mellitus

International Nuclear Information System (INIS)

Du Tongxin; Wang Zizheng

2001-01-01

To investigate the function of islet β cells in patients with gestational diabetes mellitus (GDM), serum insulin and C-peptide (C-P) excitatory test levels were measured dynamically by radioimmunoassay in 41 patients with GDM and 30 normal pregnant controls. The results showed that there were significant difference in insulin and C-peptide excitatory test levels between normal pregnancy for 32-40 weeks and patients with GDM (P < 0.001). The secretory peak of insulin occurred at 60 min in normal pregnancy, while at 120 min in patients with GDM, and the recovery postponed in patients with GDM. The peak time for C-P was just as same as that of insulin, but the peak error for C-P between normal pregnant controls and patients with GDM was more larger than that for insulin and it recovered more slowly. It suggested that majority of islet β cells in patients with GDM were good enough for response to islet resistance factors and big stress from pregnancy, and also suggested a relation between pregnancy and islet β cells function

New players tip the scales in the balance between excitatory and inhibitory synapses

Directory of Open Access Journals (Sweden)

El-Husseini Alaa

2005-03-01

Full Text Available Abstract Synaptogenesis is a highly controlled process, involving a vast array of players which include cell adhesion molecules, scaffolding and signaling proteins, neurotransmitter receptors and proteins associated with the synaptic vesicle machinery. These molecules cooperate in an intricate manner on both the pre- and postsynaptic sides to orchestrate the precise assembly of neuronal contacts. This is an amazing feat considering that a single neuron receives tens of thousands of synaptic inputs but virtually no mismatch between pre- and postsynaptic components occur in vivo. One crucial aspect of synapse formation is whether a nascent synapse will develop into an excitatory or inhibitory contact. The tight control of a balance between the types of synapses formed regulates the overall neuronal excitability, and is thus critical for normal brain function and plasticity. However, little is known about how this balance is achieved. This review discusses recent findings which provide clues to how neurons may control excitatory and inhibitory synapse formation, with focus on the involvement of the neuroligin family and PSD-95 in this process.

A Role for Excitatory Amino Acids in Diabetic Eye Disease

Directory of Open Access Journals (Sweden)

Jose E. Pulido

2007-01-01

Full Text Available Diabetic retinopathy is a leading cause of vision loss. The primary clinical hallmarks are vascular changes that appear to contribute to the loss of sight. In a number of neurodegenerative disorders there is an appreciation that increased levels of excitatory amino acids are excitotoxic. The primary amino acid responsible appears to be the neurotransmitter glutamate. This review examines the nature of glutamatergic signaling at the retina and the growing evidence from clinical and animal model studies that glutamate may be playing similar excitotoxic roles at the diabetic retina.

Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors

Directory of Open Access Journals (Sweden)

Gesche eBorn

2015-02-01

Full Text Available Human genetics has identified rare copy number variations and deleterious mutations for all neurexin genes (NRXN1-3 in patients with neurodevelopmental diseases, and electrophysiological recordings in animal brains have shown that Nrxns are important for synaptic transmission. While several mouse models for Nrxn1α inactivation have previously been studied for behavioral changes, very little information is available for other variants. Here, we validate that mice lacking Nrxn2α exhibit behavioral abnormalities, characterized by social interaction deficits and increased anxiety-like behavior, which partially overlap, partially differ from Nrxn1α mutant behaviors. Using patch-clamp recordings in Nrxn2α knockout brains, we observe reduced spontaneous transmitter release at excitatory synapses in the neocortex. We also analyse at this cellular level a novel NRXN2 mouse model that carries a combined deletion of Nrxn2α and Nrxn2β. Electrophysiological analysis of this Nrxn2-mutant mouse shows surprisingly similar defects of excitatory release to Nrxn2α, indicating that the β-variant of Nrxn2 has no strong function in basic transmission at these synapses. Inhibitory transmission as well as synapse densities and ultrastructure remain unchanged in the neocortex of both models. Furthermore, at Nrxn2α and Nrxn2-mutant excitatory synapses we find an altered facilitation and N-methyl-D-aspartate receptor (NMDAR function because NMDAR-dependent decay time and NMDAR-mediated responses are reduced. As Nrxn can indirectly be linked to NMDAR via neuroligin and PSD-95, the trans-synaptic nature of this complex may help to explain occurrence of presynaptic and postsynaptic effects. Since excitatory/inhibitory imbalances and impairment of NMDAR function are alledged to have a role in autism and schizophrenia, our results support the idea of a related pathomechanism in these disorders.

A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2 beta)

DEFF Research Database (Denmark)

Drake, P.G.; Peters, Günther H.j.; Andersen, H.S.

2003-01-01

into highly selective and potent inhibitors of PTP1B. However. since wild-type IA-2 and IA-2beta lack conventional PTP activity, a novel strategy was designed whereby catalytically active species were generated by 'back-mutating key non-consensus catalytic region residues to those of PTP1B. These mutants were...... then used as tools with which to test the potency and selectivity of OBA and a variety of its derivatives. Catalytically competent IA-2 and IA-2beta species were generated by 'back-mutation' of only three key residues (equivalent to Tyr(46). Asp(181) and Ala(217) using the human PTP1B numbering) to those...... of PTP1B. Importantly, enzyme kinetic analyses indicated that the overall fold of both mutant and wild-type IA-2 and IA-2beta was similar to that of classic PTPs. In particular, one derivative of OBA, namely 7-(1,1-dioxo-1H-benzo[d]isothiazol-3-yloxy-methyl) -2-(oxalylamino)-4,7-dihydro-5H-thieno [2,3-c...

NEUTRONIZATION DURING CARBON SIMMERING IN TYPE IA SUPERNOVA PROGENITORS

Energy Technology Data Exchange (ETDEWEB)

Martínez-Rodríguez, Héctor; Badenes, Carles [Department of Physics and Astronomy and Pittsburgh Particle Physics, Astrophysics and Cosmology Center (PITT PACC), University of Pittsburgh, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Piro, Anthony L. [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Schwab, Josiah, E-mail: hector.mr@pitt.edu [Department of Physics, University of California, Berkeley, CA 94720 (United States)

2016-07-01

When a Type Ia supernova (SN Ia) progenitor first ignites carbon in its core, it undergoes ∼10{sup 3}–10{sup 4} years of convective burning prior to the onset of thermonuclear runaway. This carbon simmering phase is important for setting the thermal profile and composition of the white dwarf. Using the MESA stellar evolution code, we follow this convective burning and examine the production of neutron-rich isotopes. The neutron content of the SN fuel has important consequences for the ensuing nucleosynthesis, and in particular, for the production of secondary Fe-peak nuclei like Mn and stable Ni. These elements have been observed in the X-ray spectra of SN remnants like Tycho, Kepler, and 3C 397, and their yields can provide valuable insights into the physics of SNe Ia and the properties of their progenitors. We find that weak reactions during simmering can at most generate a neutron excess of ≈ 3 × 10{sup −4}. This is ≈ 70% lower than that found in previous studies that do not take the full density and temperature profile of the simmering region into account. Our results imply that the progenitor metallicity is the main contributor to the neutron excess in SN Ia fuel for Z ≳ 1/3 Z {sub ⊙}. Alternatively, at lower metallicities, this neutron excess provides a floor that should be present in any centrally-ignited SN Ia scenario.

NEUTRONIZATION DURING CARBON SIMMERING IN TYPE IA SUPERNOVA PROGENITORS

International Nuclear Information System (INIS)

Martínez-Rodríguez, Héctor; Badenes, Carles; Piro, Anthony L.; Schwab, Josiah

2016-01-01

When a Type Ia supernova (SN Ia) progenitor first ignites carbon in its core, it undergoes ∼10 3 –10 4 years of convective burning prior to the onset of thermonuclear runaway. This carbon simmering phase is important for setting the thermal profile and composition of the white dwarf. Using the MESA stellar evolution code, we follow this convective burning and examine the production of neutron-rich isotopes. The neutron content of the SN fuel has important consequences for the ensuing nucleosynthesis, and in particular, for the production of secondary Fe-peak nuclei like Mn and stable Ni. These elements have been observed in the X-ray spectra of SN remnants like Tycho, Kepler, and 3C 397, and their yields can provide valuable insights into the physics of SNe Ia and the properties of their progenitors. We find that weak reactions during simmering can at most generate a neutron excess of ≈ 3 × 10 −4 . This is ≈ 70% lower than that found in previous studies that do not take the full density and temperature profile of the simmering region into account. Our results imply that the progenitor metallicity is the main contributor to the neutron excess in SN Ia fuel for Z ≳ 1/3 Z ⊙ . Alternatively, at lower metallicities, this neutron excess provides a floor that should be present in any centrally-ignited SN Ia scenario.

Bimodal effect of oxidative stress in internal anal sphincter smooth muscle

Science.gov (United States)

Singh, Jagmohan; Kumar, Sumit

2015-01-01

Changes in oxidative stress may affect basal tone and relaxation of the internal anal sphincter (IAS) smooth muscle in aging. We examined this issue by investigating the effects of the oxidative stress inducer 6-anilino-5,8-quinolinedione (LY-83583) in basal as well as U-46619-stimulated tone, and nonadrenergic, noncholinergic (NANC) relaxation in rat IAS. LY-83583, which works via generation of reactive oxygen species in living cells, produced a bimodal effect in IAS tone: lower concentrations (0.1 nM to 10 μM) produced a concentration-dependent increase, while higher concentrations (50–100 μM) produced a decrease in IAS tone. An increase in IAS tone by lower concentrations was associated with an increase in RhoA/Rho kinase (ROCK) activity. This was evident by the increase in RhoA/ROCK in the particulate fractions, in ROCK activity, and in the levels of phosphorylated (p) Thr696-myosin phosphatase target subunit 1 and pThr18/Ser19-20-kDa myosin light chain. Conversely, higher concentrations of LY-83583 produced inhibitory effects on RhoA/ROCK. Interestingly, both the excitatory and inhibitory effects of LY-83583 in the IAS were reversed by superoxide dismutase. The excitatory effects of LY-83583 were found to resemble those with neuronal nitric oxide synthase (nNOS) inhibition by l-NNA, since it produced a significant increase in the IAS tone and attenuated NANC relaxation. These effects of LY-83583 and l-NNA were reversible by l-arginine. This suggests the role of nNOS inhibition and RhoA/ROCK activation in the increase in IAS tone by LY-83583. These data have important implications in the pathophysiology and therapeutic targeting of rectoanal disorders, especially associated with IAS dysfunction. PMID:26138467

Excitatory amino acids in epilepsy and potential novel therapies.

Science.gov (United States)

Meldrum, B S

1992-07-01

Evidence that an abnormality of excitatory neurotransmission may contribute to the epileptic phenomena in various animal and human syndromes is reviewed. Altered glutamate transport or metabolism may be a contributory factor in some genetic syndromes and enhanced responsiveness to activation of NMDA receptors may be significant in various acquired forms of epilepsy. Decreasing glutamatergic neurotransmission provides a rational therapeutic approach to epilepsy. Potent anticonvulsant effects are seen with the acute administration of NMDA antagonists in a wide range of animal models. Some competitive antagonists acting at the NMDA/glutamate site show prolonged anticonvulsant activity following oral administration at doses free of motor side effects and appear suitable for clinical trial.

Accounting standards and investor perception of earnings quality: IAS/IFRS vs. German Gaap

OpenAIRE

Ferrari Mascia; Momentè Francesco; Reggiani Francesco

2011-01-01

We analyze the earnings quality under the IAS/IFRS and German GAAP by evaluating the earnings management degree in IAS and HGB adopters and by investigating what is the level of uncertainty (reliability) that investors perceive from the earnings announced. Our results show that IAS and HGB adopters do not present any significant differences in earnings management, if we examine the working capital accruals, while IAS/IFRS sub-sample is less engaged in earnings management, considering the tota...

Autologous peptides constitutively occupy the antigen binding site on Ia

DEFF Research Database (Denmark)

Buus, S; Sette, A; Colon, S M

1988-01-01

Low molecular weight material associated with affinity-purified class II major histocompatibility complex (MHC) molecules of mouse (Ia) had the expected properties of peptides bound to the antigen binding site of Ia. Thus, the low molecular weight material derived from the I-Ad isotype...

CfA3: 185 TYPE Ia SUPERNOVA LIGHT CURVES FROM THE CfA

International Nuclear Information System (INIS)

Hicken, Malcolm; Challis, Peter; Kirshner, Robert P.; Bakos, Gaspar; Berlind, Perry; Brown, Warren R.; Caldwell, Nelson; Calkins, Mike; Cho, Richard; Contreras, Maria; Jha, Saurabh; Matheson, Tom; Modjaz, Maryam; Rest, Armin; Michael Wood-Vasey, W.; Barton, Elizabeth J.; Bragg, Ann; Briceno, Cesar; Ciupik, Larry; Dendy, Kristi-Concannon

2009-01-01

We present multiband photometry of 185 type-Ia supernovae (SNe Ia), with over 11,500 observations. These were acquired between 2001 and 2008 at the F. L. Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics (CfA). This sample contains the largest number of homogeneously observed and reduced nearby SNe Ia (z ∼< 0.08) published to date. It more than doubles the nearby sample, bringing SN Ia cosmology to the point where systematic uncertainties dominate. Our natural system photometry has a precision of ∼<0.02 mag in BVRIr'i' and ∼<0.04 mag in U for points brighter than 17.5 mag. We also estimate a systematic uncertainty of 0.03 mag in our SN Ia standard system BVRIr'i' photometry and 0.07 mag for U. Comparisons of our standard system photometry with published SN Ia light curves and comparison stars, where available for the same SN, reveal agreement at the level of a few hundredths mag in most cases. We find that 1991bg-like SNe Ia are sufficiently distinct from other SNe Ia in their color and light-curve-shape/luminosity relation that they should be treated separately in light-curve/distance fitter training samples. The CfA3 sample will contribute to the development of better light-curve/distance fitters, particularly in the few dozen cases where near-infrared photometry has been obtained and, together, can help disentangle host-galaxy reddening from intrinsic supernova color, reducing the systematic uncertainty in SN Ia distances due to dust.

Prenatal ethanol exposure reduces the effects of excitatory amino acids in the rat hippocampus

International Nuclear Information System (INIS)

Noble, E.P.; Ritchie, T.

1989-01-01

Chronic alcohol ingestion during pregnancy can lead to the Fetal Alcohol Syndrome (FAS), a disorder marked by learning disabilities. A rat model of FAS was used by introducing pregnant Sprague-Dawley rats to a liquid diet containing 35% ethanol-derived calories (E), while a second group was pair-fed an isocaloric liquid diet without ethanol (P). A third group of pregnant dams received ad libitum lab chow (C). At parturition, pups from the E and P groups were cross fostered by C mothers and all groups received lab chow. During adulthood, male offspring were sacrificed and hippocampal and prefrontal cortical slices were prelabeled with [3H]inositol. Phosphoinositide (PI) hydrolysis was determined by measuring the accumulation of [3H]inositol phosphates in the presence of LiCl in response to activation of various excitatory amino acid (EAA) receptors. In hippocampal slices, ibotenate- and quisqualate-induced PI hydrolysis was reduced in E compared to P and C animals. Moreover, the inhibitory effect of N-methyl-D-aspartate (NMDA) on carbachol-induced PI hydrolysis, evident in P and C animals, was completely abolished in the hippocampus of E animals. In contrast, in the prefrontal cerebral cortex, this inhibitory effect of NMDA prevailed even in the E animals. The evidence suggests that prenatal ethanol exposure alters the activity of EAA receptors in the hippocampal generation of 2nd messengers

Rotation of the accreting white dwarfs and diversity of type Ia supernovae

International Nuclear Information System (INIS)

Uenishi, Tatsuhiro; Nomoto, Kenichi; Hachisu, Izumi

2003-01-01

We consider rotation of progenitor white dwarfs for a possible source of the diversity of Type Ia supernovae (SNe Ia). Hydrostatic structure of rotating white dwarfs with different masses are calculated. Evolutionary sequences of white dwarfs are explored and the effect of 'supercritical' rotation in binary system is examined. Possible effects of rotation to cause diversity of SNe Ia are discussed

Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit

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Lisa eMapelli

2015-05-01

Full Text Available The way long-term potentiation (LTP and depression (LTD are integrated within the different synapses of brain neuronal circuits is poorly understood. In order to progress beyond the identification of specific molecular mechanisms, a system in which multiple forms of plasticity can be correlated with large-scale neural processing is required. In this paper we take as an example the cerebellar network , in which extensive investigations have revealed LTP and LTD at several excitatory and inhibitory synapses. Cerebellar LTP and LTD occur in all three main cerebellar subcircuits (granular layer, molecular layer, deep cerebellar nuclei and correspondingly regulate the function of their three main neurons: granule cells (GrCs, Purkinje cells (PCs and deep cerebellar nuclear (DCN cells. All these neurons, in addition to be excited, are reached by feed-forward and feed-back inhibitory connections, in which LTP and LTD may either operate synergistically or homeostatically in order to control information flow through the circuit. Although the investigation of individual synaptic plasticities in vitro is essential to prove their existence and mechanisms, it is insufficient to generate a coherent view of their impact on network functioning in vivo. Recent computational models and cell-specific genetic mutations in mice are shedding light on how plasticity at multiple excitatory and inhibitory synapses might regulate neuronal activities in the cerebellar circuit and contribute to learning and memory and behavioral control.

Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia

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Colin Kehrer

2008-04-01

Full Text Available Schizophrenia is a common psychiatric disorder of high incidence, affecting approximately 1% of the world population. The essential neurotransmitter pathology of schizophrenia remains poorly defined, despite huge advances over the past half-century in identifying neurochemical and pathological abnormalities in the disease. The dopamine/serotonin hypothesis has originally provided much of the momentum for neurochemical research in schizophrenia. In recent years, the attention has, however, shifted to the glutamate system, the major excitatory neurotransmitter in the CNS and towards a concept of functional imbalance between excitatory and inhibitory transmission at the network level in various brain regions in schizophrenia. The evidence indicating a central role for the NMDAreceptor subtype in the etiology of schizophrenia has led to the NMDA-hypofunction model of this disease and the use of phencyclidines as a means to induce the NMDA-hypofunction state in animal models. The purpose of this review is to discuss recent findings highlighting the importance of the NMDA-hypofunction model of schizophrenia, both from a clinical perspective, as well as in opening a line of research, which enables electrophysiological studies at the cellular and network level in vitro. In particular, changes in excitation-inhibition (E/I balance in the NMDA-hypofunction model of the disease and the resulting changes in network behaviours, particularly in gamma frequency oscillatory activity, will be discussed.

Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit.

Science.gov (United States)

Mapelli, Lisa; Pagani, Martina; Garrido, Jesus A; D'Angelo, Egidio

2015-01-01

The way long-term potentiation (LTP) and depression (LTD) are integrated within the different synapses of brain neuronal circuits is poorly understood. In order to progress beyond the identification of specific molecular mechanisms, a system in which multiple forms of plasticity can be correlated with large-scale neural processing is required. In this paper we take as an example the cerebellar network, in which extensive investigations have revealed LTP and LTD at several excitatory and inhibitory synapses. Cerebellar LTP and LTD occur in all three main cerebellar subcircuits (granular layer, molecular layer, deep cerebellar nuclei) and correspondingly regulate the function of their three main neurons: granule cells (GrCs), Purkinje cells (PCs) and deep cerebellar nuclear (DCN) cells. All these neurons, in addition to be excited, are reached by feed-forward and feed-back inhibitory connections, in which LTP and LTD may either operate synergistically or homeostatically in order to control information flow through the circuit. Although the investigation of individual synaptic plasticities in vitro is essential to prove their existence and mechanisms, it is insufficient to generate a coherent view of their impact on network functioning in vivo. Recent computational models and cell-specific genetic mutations in mice are shedding light on how plasticity at multiple excitatory and inhibitory synapses might regulate neuronal activities in the cerebellar circuit and contribute to learning and memory and behavioral control.

Coréia aguda na gravidez

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Walter C. Pereira

1967-12-01

Full Text Available São apresentados doze casos de coréia aguda observados entre 150.000 gestantes (1/12.500. A maioria dos surtos ocorreu no segundo trimestre da primeira gravidez. A duração média dos sintomas foi de três meses, não tendo sido registrado caso algum de óbito materno. Todos os partos foram espontâneos e normais. Houve apenas um óbito fetal conseqüente a choque hemorrágico. São tecidas considerações a propósito dos aspectos clínico, laboratorial e prognóstico da coréia gravídica, sendo focalizado mais pormenorizadamente o problema fisiopatogênico dessa afecção.

SPECTROSCOPIC OBSERVATIONS OF SN 2012fr: A LUMINOUS, NORMAL TYPE Ia SUPERNOVA WITH EARLY HIGH-VELOCITY FEATURES AND A LATE VELOCITY PLATEAU

International Nuclear Information System (INIS)

Childress, M. J.; Scalzo, R. A.; Sim, S. A.; Tucker, B. E.; Yuan, F.; Schmidt, B. P.; Cenko, S. B.; Filippenko, A. V.; Silverman, J. M.; Contreras, C.; Hsiao, E. Y.; Phillips, M.; Morrell, N.; Jha, S. W.; McCully, C.; Anderson, J. P.; De Jaeger, T.; Forster, F.; Benetti, S.; Bufano, F.

2013-01-01

We present 65 optical spectra of the Type Ia SN 2012fr, 33 of which were obtained before maximum light. At early times, SN 2012fr shows clear evidence of a high-velocity feature (HVF) in the Si II λ6355 line that can be cleanly decoupled from the lower velocity ''photospheric'' component. This Si II λ6355 HVF fades by phase –5; subsequently, the photospheric component exhibits a very narrow velocity width and remains at a nearly constant velocity of ∼12,000 km s –1 until at least five weeks after maximum brightness. The Ca II infrared triplet exhibits similar evidence for both a photospheric component at v ≈ 12,000 km s –1 with narrow line width and long velocity plateau, as well as an HVF beginning at v ≈ 31,000 km s –1 two weeks before maximum. SN 2012fr resides on the border between the ''shallow silicon'' and ''core-normal'' subclasses in the Branch et al. classification scheme, and on the border between normal and high-velocity Type Ia supernovae (SNe Ia) in the Wang et al. system. Though it is a clear member of the ''low velocity gradient'' group of SNe Ia and exhibits a very slow light-curve decline, it shows key dissimilarities with the overluminous SN 1991T or SN 1999aa subclasses of SNe Ia. SN 2012fr represents a well-observed SN Ia at the luminous end of the normal SN Ia distribution and a key transitional event between nominal spectroscopic subclasses of SNe Ia.

Audit Fees and IAS/IFRS Adoption: Evidence from the Banking Industry

OpenAIRE

Perotti, Pietro; Cameran, Mara

2014-01-01

The adoption of International Accounting Standards/International Financial Reporting Standards (IAS/IFRS) has two opposite effects on audit fees: on the one hand, greater effort is required from auditors, which is likely to be reflected by higher fees; on the other hand, if IAS/IFRS improve the quality of financial reporting, expected liability costs could decrease and lower fees may be demanded. We consider a large sample of Italian banks and we examine the effect of IAS/IFRS adoption on aud...

Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons

NARCIS (Netherlands)

Caillé, S.; Guillem, K.; Cador, M.; Manzoni, O.; Georges, F.

2009-01-01

Active response to either natural or pharmacological reward causes synaptic modifications to excitatory synapses on dopamine (DA) neurons of the ventral tegmental area (VTA). Here, we examine these modifications using nicotine, the main addictive component of tobacco, which is a potent regulator of

Excitatory and inhibitory pathways modulate kainate excitotoxicity in hippocampal slice cultures

DEFF Research Database (Denmark)

Casaccia-Bonnefil, P; Benedikz, Eirikur; Rai, R

1993-01-01

In organotypic hippocampal slice cultures, kainate (KA) specifically induces cell loss in the CA3 region while N-methyl-D-aspartate induces cell loss in the CA1 region. The sensitivity of slice cultures to KA toxicity appears only after 2 weeks in vitro which parallels the appearance of mossy...... fibers. KA toxicity is potentiated by co-application with the GABA-A antagonist, picrotoxin. These data suggest that the excitotoxicity of KA in slice cultures is modulated by both excitatory and inhibitory synapses....

Enhanced excitatory input to melanin concentrating hormone neurons during developmental period of high food intake is mediated by GABA.

Science.gov (United States)

Li, Ying; van den Pol, Anthony N

2009-12-02

In contrast to the local axons of GABA neurons of the cortex and hippocampus, lateral hypothalamic neurons containing melanin concentrating hormone (MCH) and GABA send long axons throughout the brain and play key roles in energy homeostasis and mental status. In adults, MCH neurons maintain a hyperpolarized membrane potential and most of the synaptic input is inhibitory. In contrast, we found that developing MCH neurons received substantially more excitatory synaptic input. Based on gramicidin-perforated patch recordings in hypothalamic slices from MCH-green fluorescent protein transgenic mice, we found that GABA was the primary excitatory synaptic transmitter in embryonic and neonatal ages up to postnatal day 10. Surprisingly, glutamate assumed only a minor excitatory role, if any. GABA plays a complex role in developing MCH neurons, with its actions conditionally dependent on a number of factors. GABA depolarization could lead to an increase in spikes either independently or in summation with other depolarizing stimuli, or alternately, depending on the relative timing of other depolarizing events, could lead to shunting inhibition. The developmental shift from depolarizing to hyperpolarizing occurred later in the dendrites than in the cell body. Early GABA depolarization was based on a Cl(-)-dependent inward current. An interesting secondary depolarization in mature neurons that followed an initial hyperpolarization was based on a bicarbonate mechanism. Thus during the early developmental period when food consumption is high, MCH neurons are more depolarized than in the adult, and an increased level of excitatory synaptic input to these orexigenic cells is mediated by GABA.

Excitatory inputs to four types of spinocerebellar tract neurons in the cat and the rat thoraco-lumbar spinal cord

Science.gov (United States)

Shrestha, Sony Shakya; Bannatyne, B Anne; Jankowska, Elzbieta; Hammar, Ingela; Nilsson, Elin; Maxwell, David J

2012-01-01

The cerebellum receives information from the hindlimbs through several populations of spinocerebellar tract neurons. Although the role of these neurons has been established in electrophysiological experiments, the relative contribution of afferent fibres and central neurons to their excitatory input has only been estimated approximately so far. Taking advantage of differences in the immunohistochemistry of glutamatergic terminals of peripheral afferents and of central neurons (with vesicular glutamate transporters VGLUT1 or VGLUT2, respectively), we compared sources of excitatory input to four populations of spinocerebellar neurons in the thoraco-lumbar spinal cord: dorsal spinocerebellar tract neurons located in Clarke's column (ccDSCT) and in the dorsal horn (dhDSCT) and ventral spinocerebellar tract (VSCT) neurons including spinal border (SB) neurons. This was done on 22 electrophysiologically identified intracellularly labelled neurons in cats and on 80 neurons labelled by retrograde transport of cholera toxin b subunit injected into the cerebellum of rats. In both species distribution of antibodies against VGLUT1 and VGLUT2 on SB neurons (which have dominating inhibitory input from limb muscles), revealed very few VGLUT1 contacts and remarkably high numbers of VGLUT2 contacts. In VSCT neurons with excitatory afferent input, the number of VGLUT1 contacts was relatively high although VGLUT2 contacts likewise dominated, while the proportions of VGLUT1 and VGLUT2 immunoreactive terminals were the reverse on the two populations of DSCT neurons. These findings provide morphological evidence that SB neurons principally receive excitatory inputs from central neurons and provide the cerebellum with information regarding central neuronal activity. PMID:22371473

IAS 12 needs methodical approach

NARCIS (Netherlands)

Hafkenscheid, R.P.F.M.; Janssen, C.M.L.

2009-01-01

The article describes a methodology used to establish the expected value of uncertain tax positions. The Project Update on Income Taxes released by the International Accounting Standards Board (IASB) in September 2008 aims to reduce the differences between IAS 12 Income Taxes and the SFAS 109

Cortical Divergent Projections in Mice Originate from Two Sequentially Generated, Distinct Populations of Excitatory Cortical Neurons with Different Initial Axonal Outgrowth Characteristics.

Science.gov (United States)

Hatanaka, Yumiko; Namikawa, Tomohiro; Yamauchi, Kenta; Kawaguchi, Yasuo

2016-05-01

Excitatory cortical neurons project to various subcortical and intracortical regions, and exhibit diversity in their axonal connections. Although this diversity may develop from primary axons, how many types of axons initially occur remains unknown. Using a sparse-labeling in utero electroporation method, we investigated the axonal outgrowth of these neurons in mice and correlated the data with axonal projections in adults. Examination of lateral cortex neurons labeled during the main period of cortical neurogenesis (E11.5-E15.5) indicated that axonal outgrowth commonly occurs in the intermediate zone. Conversely, the axonal direction varied; neurons labeled before E12.5 and the earliest cortical plate neurons labeled at E12.5 projected laterally, whereas neurons labeled thereafter projected medially. The expression of Ctip2 and Satb2 and the layer destinations of these neurons support the view that lateral and medial projection neurons are groups of prospective subcortical and callosal projection neurons, respectively. Consistently, birthdating experiments demonstrated that presumptive lateral projection neurons were generated earlier than medial projection neurons, even within the same layer. These results suggest that the divergent axonal connections of excitatory cortical neurons begin from two types of primary axons, which originate from two sequentially generated distinct subpopulations: early-born lateral (subcortical) and later-born medial (callosal) projection neuron groups. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

VELOCITY EVOLUTION AND THE INTRINSIC COLOR OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Foley, Ryan J.; Sanders, Nathan E.; Kirshner, Robert P.

2011-01-01

To understand how best to use observations of Type Ia supernovae (SNe Ia) to obtain precise and accurate distances, we investigate the relations between spectra of SNe Ia and their intrinsic colors. Using a sample of 1630 optical spectra of 255 SNe, based primarily on data from the CfA Supernova Program, we examine how the velocity evolution and line strengths of Si II λ6355 and Ca II H and K are related to the B – V color at peak brightness. We find that the maximum-light velocity of Si II λ6355 and Ca II H and K and the maximum-light pseudo-equivalent width of Si II λ6355 are correlated with intrinsic color, with intrinsic color having a linear relation with the Si II λ6355 measurements. Ca II H and K does not have a linear relation with intrinsic color, but lower-velocity SNe tend to be intrinsically bluer. Combining the spectroscopic measurements does not improve intrinsic color inference. The intrinsic color scatter is larger for higher-velocity SNe Ia—even after removing a linear trend with velocity—indicating that lower-velocity SNe Ia are more 'standard crayons'. Employing information derived from SN Ia spectra has the potential to improve the measurements of extragalactic distances and the cosmological properties inferred from them.

Boracéia Biological Station: an ornithological review

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Vagner Cavarzere

2010-01-01

Full Text Available Boracéia Biological Station, near the city of Salesópolis, SP, is located in one of the most well-defined centers of endemism in eastern Brazil - the Serra do Mar Center. While the station was established only in 1954 under the auspices of the Museu de Zoologia da Universidade de São Paulo, the avifauna of this locality had already attracted the attention of ornithologists by the 1940s, when the first specimens were collected. Here we describe the ornithological history of the Boracéia Biological Station with a review of all the bird species recorded during more than 68 years, including recent transect and mist-netting records. Boracéia's records were found in museums, literature and unpublished reports that totaled 323 bird species when recent data is also considered. Of these, 117 are endemic to the Atlantic forest and 28 are threatened in the state. Although there are a few doubtful records that need to be checked, some species are the only sightings in the state. Boracéia includes a recently discovered species near the station site and is extremely important for the conservation of Atlantic forest birds.A Estação Biológica de Boracéia, localizada em Salesópolis, SP, situa-se na Serra do Mar, importante região biogeográfica e um dos centros de endemismo mais bem definidos do Brasil. Apesar de instituída em 1954, quando passou a pertencer ao Museu de Zoologia da Universidade de São Paulo, a avifauna desta localidade já era objeto de pesquisas desde a década de 1940, época em que foram realizadas as primeiras coletas de aves. Aqui é apresentada pela primeira vez uma revisão de todos os registros avifaunísticos realizados nessa localidade ao longo de mais de 68 anos assim como a adição de novos registros com base em dados coletados recentemente com transectos lineares e redes de neblina. Os registros para Boracéia estiveram representados em museus, na literatura e em dados não publicados que, somados aos registros

The Impact of Microlensing on the Standardisation of Strongly Lensed Type Ia Supernovae

Science.gov (United States)

Foxley-Marrable, Max; Collett, Thomas E.; Vernardos, Georgios; Goldstein, Daniel A.; Bacon, David

2018-05-01

We investigate the effect of microlensing on the standardisation of strongly lensed Type Ia supernovae (GLSNe Ia). We present predictions for the amount of scatter induced by microlensing across a range of plausible strong lens macromodels. We find that lensed images in regions of low convergence, shear and stellar density are standardisable, where the microlensing scatter is ≲ 0.15 magnitudes, comparable to the intrinsic dispersion of for a typical SN Ia. These standardisable configurations correspond to asymmetric lenses with an image located far outside the Einstein radius of the lens. Symmetric and small Einstein radius lenses (≲ 0.5 arcsec) are not standardisable. We apply our model to the recently discovered GLSN Ia iPTF16geu and find that the large discrepancy between the observed flux and the macromodel predictions from More et al. (2017) cannot be explained by microlensing alone. Using the mock GLSNe Ia catalogue of Goldstein et al. (2017), we predict that ˜ 22% of GLSNe Ia discovered by LSST will be standardisable, with a median Einstein radius of 0.9 arcseconds and a median time-delay of 41 days. By breaking the mass-sheet degeneracy the full LSST GLSNe Ia sample will be able to detect systematics in H0 at the 0.5% level.

A Second Ladder: Testing for Bias in the Type Ia Distance Scale with SBF

Science.gov (United States)

Milne, Peter

2016-10-01

We propose obtaining Surface Brightness Fluctuation (SBF) distances to the hosts galaxies of 20 nearby type Ia supernovae (SNe Ia), resulting in a sample of 29 SNe Ia in 27 galaxies when combined with HST-SBF distances from the literature. This sample can then be compared with the existing 18 SN Ia distances from Cepheids. Through these comparisons, we will determine if there are any discrepancies between the SBF distance scale, which is extended into the Hubble flow using early-type galaxies, and the SNIa distance scale, for which local calibrators are scarce and host galaxy types and SN environments are heterogenous. Since recent measurements of UV-optical colors suggest that SN Ia properties do depend on galaxy type and environment, it is essential that SNe Ia in all galaxy types are included when extending SN Ia distances to the distant Hubble flow. Since the conclusion that universal expansion is accelerating was originally based on SNe Ia distances, and because recent measurements of UV-optical colors suggest that SN Ia properties do depend on galaxy type and environment, it is essential to measure the same types of SNe in the same types of galaxies. To meet this goal, we propose to measure high-precision SBF distances to all early-type galaxies that have hosted SNIa within 80 Mpc. We will therefore be able to distinguish between systematic offsets in the derived Hubble constant between galaxies and/or SNe of different types and correct for them. SBF is the only distance measurement technique with statistical uncertainties comparable to SN Ia that can be applied to the early-type of galaxies in which the majority of the high-redshift SNIa occur.

Double-detonation model of type Ia supernovae with a variable helium layer ignition mass

International Nuclear Information System (INIS)

Zhou Wei-Hong; Zhao Gang; Wang Bo

2014-01-01

Although Type Ia supernovae (SNe Ia) play an important role in the study of cosmology, their progenitors are still poorly understood. Thermonuclear explosions from the helium double-detonation sub-Chandrasekhar mass model have been considered as an alternative method for producing SNe Ia. By adopting the assumption that a double detonation occurs when a He layer with a critical ignition mass accumulates on the surface of a carbon—oxygen white dwarf (CO WD), we perform detailed binary evolution calculations for the He double-detonation model, in which a He layer from a He star accumulates on a CO WD. According to these calculations, we obtain the initial parameter spaces for SNe Ia in the orbital period and secondary mass plane for various initial WD masses. We implement these results into a detailed binary population synthesis approach to calculate SN Ia birthrates and delay times. From this model, the SN Ia birthrate in our Galaxy is ∼0.4 − 1.6 × 10 −3 yr −1 . This indicates that the double-detonation model only produces part of the SNe Ia. The delay times from this model are ∼ 70 – 710 Myr, which contribute to the young population of SNe Ia in the observations. We found that the CO WD + sdB star system CD–30 11223 could produce an SN Ia via the double-detonation model in its future evolution. (research papers)

3D Simulations of Supernova Remnants from Type Ia Supernova Models

Science.gov (United States)

Johnson, Heather; Reynolds, S. P.; Frohlich, C.; Blondin, J. M.

2014-01-01

Type Ia supernovae (SNe) originate from thermonuclear explosions of white dwarfs. A great deal is still unknown about the explosion mechanisms, particularly the degree of asymmetry. However, Type Ia supernova remnants (SNRs) can bear the imprint of asymmetry long after the explosion. A SNR of interest is G1.9+0.3, the youngest Galactic SNR, which demonstrates an unusual spatial distribution of elements in the ejecta. While its X-ray spectrum is dominated by synchrotron emission, spectral lines of highly ionized Si, S, and Fe are seen in a few locations, with Fe near the edge of the remnant and with strongly varying Fe/Si ratios. An asymmetric explosion within the white dwarf progenitor may be necessary to explain these unusual features of G1.9+0.3, in particular the shocked Fe at large radii. We use the VH-1 hydrodynamics code to evolve initial Type Ia explosion models in 1, 2, and 3 dimensions at an age of 100 seconds provided by other researchers to study asymmetry, the ignition properties, and the nucleosynthesis resulting from these explosions. We follow the evolution of these models interacting with a uniform external medium to a few hundred years in age. We find the abundance and location of ejecta elements from our models to be inconsistent with the observations of G1.9+0.3; while our models show asymmetric element distributions, we find no tendency for iron-group elements to be found beyond intermediate-mass elements, or for significant iron to be reverse-shocked at all at the age of G1.9+0.3. We compare the amounts of shocked iron-group and intermediate-mass elements as a function of time in the different models. Some new kind of explosion asymmetry may be required to explain G1.9+0.3. This work was performed as part of NC State University's Undergraduate Research in Computational Astrophysics (URCA) program, an REU program supported by the National Science Foundation through award AST-1032736.

Enhanced quantal release of excitatory transmitter in anterior cingulate cortex of adult mice with chronic pain

Directory of Open Access Journals (Sweden)

Zhao Ming-Gao

2009-01-01

Full Text Available Abstract The anterior cingulate cortex (ACC is a forebrain structure that plays important roles in emotion, learning, memory and persistent pain. Our previous studies have demonstrated that the enhancement of excitatory synaptic transmission was induced by peripheral inflammation and nerve injury in ACC synapses. However, little information is available on their presynaptic mechanisms, since the source of the enhanced synaptic transmission could include the enhanced probability of neurotransmitter release at existing release sites and/or increases in the number of available vesicles. The present study aims to perform quantal analysis of excitatory synapses in the ACC with chronic pain to examine the source of these increases. The quantal analysis revealed that both probability of transmitter release and number of available vesicles were increased in a mouse model of peripheral inflammation, whereas only probability of transmitter release but not number of available vesicles was enhanced in a mouse model of neuropathic pain. In addition, we compared the miniature excitatory postsynaptic potentials (mEPSCs in ACC synapses with those in other pain-related brain areas such as the amygdala and spinal cord. Interestingly, the rate and amplitude of mEPSCs in ACC synapses were significantly lower than those in the amygdala and spinal cord. Our studies provide strong evidences that chronic inflammatory pain increases both probability of transmitter release and number of available vesicles, whereas neuropathic pain increases only probability of transmitter release in the ACC synapses.

Cosmological parameter uncertainties from SALT-II type Ia supernova light curve models

International Nuclear Information System (INIS)

Mosher, J.; Sako, M.; Guy, J.; Astier, P.; Betoule, M.; El-Hage, P.; Pain, R.; Regnault, N.; Kessler, R.; Frieman, J. A.; Marriner, J.; Biswas, R.; Kuhlmann, S.; Schneider, D. P.

2014-01-01

We use simulated type Ia supernova (SN Ia) samples, including both photometry and spectra, to perform the first direct validation of cosmology analysis using the SALT-II light curve model. This validation includes residuals from the light curve training process, systematic biases in SN Ia distance measurements, and a bias on the dark energy equation of state parameter w. Using the SN-analysis package SNANA, we simulate and analyze realistic samples corresponding to the data samples used in the SNLS3 analysis: ∼120 low-redshift (z < 0.1) SNe Ia, ∼255 Sloan Digital Sky Survey SNe Ia (z < 0.4), and ∼290 SNLS SNe Ia (z ≤ 1). To probe systematic uncertainties in detail, we vary the input spectral model, the model of intrinsic scatter, and the smoothing (i.e., regularization) parameters used during the SALT-II model training. Using realistic intrinsic scatter models results in a slight bias in the ultraviolet portion of the trained SALT-II model, and w biases (w input – w recovered ) ranging from –0.005 ± 0.012 to –0.024 ± 0.010. These biases are indistinguishable from each other within the uncertainty; the average bias on w is –0.014 ± 0.007.

Cosmological Parameter Uncertainties from SALT-II Type Ia Supernova Light Curve Models

Energy Technology Data Exchange (ETDEWEB)

Mosher, J. [Pennsylvania U.; Guy, J. [LBL, Berkeley; Kessler, R. [Chicago U., KICP; Astier, P. [Paris U., VI-VII; Marriner, J. [Fermilab; Betoule, M. [Paris U., VI-VII; Sako, M. [Pennsylvania U.; El-Hage, P. [Paris U., VI-VII; Biswas, R. [Argonne; Pain, R. [Paris U., VI-VII; Kuhlmann, S. [Argonne; Regnault, N. [Paris U., VI-VII; Frieman, J. A. [Fermilab; Schneider, D. P. [Penn State U.

2014-08-29

We use simulated type Ia supernova (SN Ia) samples, including both photometry and spectra, to perform the first direct validation of cosmology analysis using the SALT-II light curve model. This validation includes residuals from the light curve training process, systematic biases in SN Ia distance measurements, and a bias on the dark energy equation of state parameter w. Using the SN-analysis package SNANA, we simulate and analyze realistic samples corresponding to the data samples used in the SNLS3 analysis: ~120 low-redshift (z < 0.1) SNe Ia, ~255 Sloan Digital Sky Survey SNe Ia (z < 0.4), and ~290 SNLS SNe Ia (z ≤ 1). To probe systematic uncertainties in detail, we vary the input spectral model, the model of intrinsic scatter, and the smoothing (i.e., regularization) parameters used during the SALT-II model training. Using realistic intrinsic scatter models results in a slight bias in the ultraviolet portion of the trained SALT-II model, and w biases (w (input) – w (recovered)) ranging from –0.005 ± 0.012 to –0.024 ± 0.010. These biases are indistinguishable from each other within the uncertainty, the average bias on w is –0.014 ± 0.007.

SPECTROSCOPY OF TYPE Ia SUPERNOVAE BY THE CARNEGIE SUPERNOVA PROJECT

International Nuclear Information System (INIS)

Folatelli, Gastón; Morrell, Nidia; Phillips, Mark M.; Hsiao, Eric; Campillay, Abdo; Contreras, Carlos; Castellón, Sergio; Roth, Miguel; Hamuy, Mario; Anderson, Joseph P.; Krzeminski, Wojtek; Stritzinger, Maximilian; Burns, Christopher R.; Freedman, Wendy L.; Madore, Barry F.; Murphy, David; Persson, S. E.; Prieto, José L.; Suntzeff, Nicholas B.; Krisciunas, Kevin

2013-01-01

This is the first release of optical spectroscopic data of low-redshift Type Ia supernovae (SNe Ia) by the Carnegie Supernova Project including 604 previously unpublished spectra of 93 SNe Ia. The observations cover a range of phases from 12 days before to over 150 days after the time of B-band maximum light. With the addition of 228 near-maximum spectra from the literature, we study the diversity among SNe Ia in a quantitative manner. For that purpose, spectroscopic parameters are employed such as expansion velocities from spectral line blueshifts and pseudo-equivalent widths (pW). The values of those parameters at maximum light are obtained for 78 objects, thus providing a characterization of SNe Ia that may help to improve our understanding of the properties of the exploding systems and the thermonuclear flame propagation. Two objects, namely, SNe 2005M and 2006is, stand out from the sample by showing peculiar Si II and S II velocities but otherwise standard velocities for the rest of the ions. We further study the correlations between spectroscopic and photometric parameters such as light-curve decline rate and color. In agreement with previous studies, we find that the pW of Si II absorption features are very good indicators of light-curve decline rate. Furthermore, we demonstrate that parameters such as pW2 (Si II 4130) and pW6 (Si II 5972) provide precise calibrations of the peak B-band luminosity with dispersions of ≈0.15 mag. In the search for a secondary parameter in the calibration of peak luminosity for SNe Ia, we find a ≈2σ-3σ correlation between B-band Hubble residuals and the velocity at maximum light of S II and Si II lines

SPECTROSCOPY OF TYPE Ia SUPERNOVAE BY THE CARNEGIE SUPERNOVA PROJECT

Energy Technology Data Exchange (ETDEWEB)

Folatelli, Gaston [Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), Todai Institutes for Advanced Study, the University of Tokyo, 277-8583 Kashiwa (Japan); Morrell, Nidia; Phillips, Mark M.; Hsiao, Eric; Campillay, Abdo; Contreras, Carlos; Castellon, Sergio; Roth, Miguel [Las Campanas Observatory, Carnegie Observatories, Casilla 601, La Serena (Chile); Hamuy, Mario; Anderson, Joseph P. [Departamento de Astronomia, Universidad de Chile, Casilla 36-D, Santiago (Chile); Krzeminski, Wojtek [N. Copernicus Astronomical Center, ul. Bartycka 18, 00-716 Warszawa (Poland); Stritzinger, Maximilian [Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark); Burns, Christopher R.; Freedman, Wendy L.; Madore, Barry F.; Murphy, David; Persson, S. E. [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Prieto, Jose L. [Department of Astrophysical Sciences, Princeton University, 4 Ivy Ln., Princeton, NJ 08544 (United States); Suntzeff, Nicholas B.; Krisciunas, Kevin, E-mail: gaston.folatelli@ipmu.jp [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States); and others

2013-08-10

This is the first release of optical spectroscopic data of low-redshift Type Ia supernovae (SNe Ia) by the Carnegie Supernova Project including 604 previously unpublished spectra of 93 SNe Ia. The observations cover a range of phases from 12 days before to over 150 days after the time of B-band maximum light. With the addition of 228 near-maximum spectra from the literature, we study the diversity among SNe Ia in a quantitative manner. For that purpose, spectroscopic parameters are employed such as expansion velocities from spectral line blueshifts and pseudo-equivalent widths (pW). The values of those parameters at maximum light are obtained for 78 objects, thus providing a characterization of SNe Ia that may help to improve our understanding of the properties of the exploding systems and the thermonuclear flame propagation. Two objects, namely, SNe 2005M and 2006is, stand out from the sample by showing peculiar Si II and S II velocities but otherwise standard velocities for the rest of the ions. We further study the correlations between spectroscopic and photometric parameters such as light-curve decline rate and color. In agreement with previous studies, we find that the pW of Si II absorption features are very good indicators of light-curve decline rate. Furthermore, we demonstrate that parameters such as pW2 (Si II 4130) and pW6 (Si II 5972) provide precise calibrations of the peak B-band luminosity with dispersions of Almost-Equal-To 0.15 mag. In the search for a secondary parameter in the calibration of peak luminosity for SNe Ia, we find a Almost-Equal-To 2{sigma}-3{sigma} correlation between B-band Hubble residuals and the velocity at maximum light of S II and Si II lines.

Interpersonal Attraction in Dyads and Groups: Effects of the Hearts of the Beholder and the Beheld.

Science.gov (United States)

Malloy, Thomas E

2018-04-01

Dyadic interpersonal attraction (IA) was studied within groups of very highly acquainted family members, friends and co-workers. IA was determined by the perceiver (i.e., the heart of the beholder), the target (i.e., the heart of the beheld), and in specific dyads, by the unique combination of the two. The consistency of one's attraction to others and others' attraction to the person across groups were addressed using the key person design . Attraction to a person in one group was independent of attraction to that person in another, although people predicted that members of different groups were similarly attracted to them. A new model (ARRMA) was specified to simultaneously study assumed reciprocity, actual reciprocity, and metaperception accuracy of attraction (i.e., accurate predictions of others' attraction to oneself). Assumed reciprocity of IA was substantial at the individual and dyadic levels. Reciprocity of attraction at the individual level, a heretofore unconfirmed "plausible hypothesis" (Newcomb, 1979), was supported; dyadic reciprocity was weak. Meta-accuracy of IA was observed among individuals but was weak in dyads. Perceived interpersonal similarity predicted IA among individuals and in specific dyads. Considering dyadic attraction within and between groups, and the use of componential analysis permitted the specification of new IA phenomena and resolved a long standing theoretical problem regarding the reciprocity of attraction.

A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields

Directory of Open Access Journals (Sweden)

Keith P. Johnson

2018-02-01

Full Text Available The spike trains of retinal ganglion cells (RGCs are the only source of visual information to the brain. Here, we genetically identify an RGC type in mice that functions as a pixel encoder and increases firing to light increments (PixON-RGC. PixON-RGCs have medium-sized dendritic arbors and non-canonical center-surround receptive fields. From their receptive field center, PixON-RGCs receive only excitatory input, which encodes contrast and spatial information linearly. From their receptive field surround, PixON-RGCs receive only inhibitory input, which is temporally matched to the excitatory center input. As a result, the firing rate of PixON-RGCs linearly encodes local image contrast. Spatially offset (i.e., truly lateral inhibition of PixON-RGCs arises from spiking GABAergic amacrine cells. The receptive field organization of PixON-RGCs is independent of stimulus wavelength (i.e., achromatic. PixON-RGCs project predominantly to the dorsal lateral geniculate nucleus (dLGN of the thalamus and likely contribute to visual perception.

Type Ia supernovae yielding distances with 3-4% precision

Energy Technology Data Exchange (ETDEWEB)

Kelly, Patrick L. [Univ. of California, Berkeley, CA (United States); Filippenko, Alexei V. [Univ. of California, Berkeley, CA (United States); Burke, David L. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Hicken, Malcolm [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Ganeshalingam, Mohan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Zheng, Weikang [Univ. of California, Berkeley, CA (United States)

2015-01-26

The luminosities of Type Ia supernovae (SN), the thermonuclear explosions of white dwarf stars, vary systematically with their intrinsic color and light-curve decline rate. These relationships have been used to calibrate their luminosities to within ~0.14–0.20 mag from broadband optical light curves, yielding individual distances accurate to ~7–10%. Here we identify a subset of SN Ia that erupt in environments having high ultraviolet surface brightness and star-formation surface density. When we apply a steep model extinction law, these SN can be calibrated to within ~0.065–0.075 mag, corresponding to ~3–4% in distance — the best yet with SN Ia by a substantial margin. The small scatter suggests that variations in only one or two progenitor properties account for their light-curve-width/color/luminosity relation.

Error Analysis of Ia Supernova and Query on Cosmic Dark Energy

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... Error Analysis of Ia Supernova and Query on Cosmic Dark Energy. Qiuhe Peng Yiming Hu Kun ... https://www.ias.ac.in/article/fulltext/joaa/035/03/0253-0256 ... Articles are also visible in Web of Science immediately. All these ...

Structural analysis of peptides capable of binding to more than one Ia antigen

DEFF Research Database (Denmark)

Sette, A; Buus, S; Colon, S

1989-01-01

The Ia binding regions were analyzed for three unrelated peptide Ag (sperm whale myoglobin 106-118, influenza hemagglutinin 130-142, and lambda repressor protein 12-26) for which binding to more than one Ia molecule has previously been demonstrated. By determining the binding profile of three...... separate series of truncated synthetic peptides, it was found that in all three cases the different Ia reactivities mapped to largely overlapping regions of the peptides; although, for two of the peptides, the regions involved in binding the different Ia specificities were distinct. Moreover, subtle...... differences were found to dramatically influence some, but not other, Ia reactivities. Using a large panel of synthetic peptides it was found that a significant correlation exists between the capacity of peptides to interact with different alleles of the same molecule (i.e., IAd and IAk), but no correlation...

Comparison of distance information given by SN Ia, BAO and CMB

International Nuclear Information System (INIS)

Li Hong

2011-01-01

The observations of Type Ia supernovae (SN Ia), Baryon Acoustic Oscillations (BAO) and Cosmic Microwave Background radiation (CMB) provide powerful tools for the measurement of cosmological parameters. One of the most useful information encodes in the distance measured by those probes. In this Letter, we test the coherence of the observational information provided by SN Ia, BAO and CMB experiments. We make two kinds of comparison: the first is the constraints on cosmological parameters of the equation of state parameter (EoS) of dark energy (DE) and matter budget parameter Ω m from the latest data by global fitting, and we find the large discrepancy from those different probes. The second comparison is performed among the derived distance information from these observations at certain appointed redshift, the results show that the distance provided by WMAP5 are larger than those from SN Ia and BAO on the whole.

The curious case of SN 2011dn: A very peculiar type Ia supernova?

Science.gov (United States)

Rachubo, Alisa

Type Ia supernovae (SNe Ia) are excellent cosmological distance indicators due to the uniformity in their light curves, which led to the major discovery of the accelerated expansion of the universe. However, SNe Ia are not so uniform as one may expect, as there are many peculiar SNe Ia that exhibit differences in their photometric and spectroscopic behavior from normal SNe Ia. One of the goals of supernova cosmology today is to produce a cleaner sample of SNe Ia without these peculiar SNe Ia. Here we consider SN 2011dn, a peculiar SN Ia candidate. In 2011, Salvo, et al. carried out a preliminary analysis of a subset of the data prescribed here, and identified spectral and photometric peculiarities in this object's evolution that warranted further analysis. Here, we present a complete re-reduction and reanalysis of B, V,R, and I photometry of SN 2011dn obtained at Mount Laguna Observatory, spanning from 7 days before maximum light in B to 88 days past maximum light. In addition, we also consider total flux spectra from 9 days before maximum light to 4 days after maximum light, along with ultraviolet (UV) photometry obtained with the Swift telescope. From SN 2011dn's optical spectra, we find that SN 2011dn most closely resembles a SN 1991T-like type Ia supernova ('91T-like SN Ia). Such SNe Ia are typically more luminous than normal SNe Ia, and possess broader (i.e., they decline less rapidly than normal from maximum light) light curves. Their Deltam15(B) (drop in B magnitude 15 days after maximum light) are typically significantly less than the canonical value of 1.1, and can be as low as 0.8. In the earlier preliminary analysis, Salvo et al. measured a surprisingly high Deltam15(B) value for SN 2011dn, of ˜ 1.1. Since SN 2011dn was embedded in UGC 11501 (its host galaxy), however, it is possible that some of the light from the host galaxy was included in the photometric aperture, resulting in inaccurate photometric measurements. Here, in order to better isolate the

THEORETICAL CLUES TO THE ULTRAVIOLET DIVERSITY OF TYPE Ia SUPERNOVAE

Energy Technology Data Exchange (ETDEWEB)

Brown, Peter J.; Wang, Lifan [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Texas A. and M. University, Department of Physics and Astronomy, 4242 TAMU, College Station, TX 77843 (United States); Baron, E. [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, 440 W. Brooks, Rm 100, Norman, OK 73019-2061 (United States); Milne, Peter [Steward Observatory, University of Arizona, Tucson, AZ 85719 (United States); Roming, Peter W. A., E-mail: pbrown@physics.tamu.edu [Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78238 (United States)

2015-08-10

The effect of metallicity on the observed light of Type Ia supernovae (SNe Ia) could lead to systematic errors as the absolute magnitudes of local and distant SNe Ia are compared to measure luminosity distances and determine cosmological parameters. The UV light may be especially sensitive to metallicity, though different modeling methods disagree as to the magnitude, wavelength dependence, and even the sign of the effect. The outer density structure, {sup 56}Ni, and to a lesser degree asphericity, also impact the UV. We compute synthetic photometry of various metallicity-dependent models and compare to UV/optical photometry from the Swift Ultra-Violet/Optical Telescope. We find that the scatter in the mid-UV to near-UV colors is larger than predicted by changes in metallicity alone and is not consistent with reddening. We demonstrate that a recently employed method to determine relative abundances using UV spectra can be done using UVOT photometry, but we warn that accurate results require an accurate model of the cause of the variations. The abundance of UV photometry now available should provide constraints on models that typically rely on UV spectroscopy for constraining metallicity, density, and other parameters. Nevertheless, UV spectroscopy for a variety of supernova explosions is still needed to guide the creation of accurate models. A better understanding of the influences affecting the UV is important for using SNe Ia as cosmological probes, as the UV light may test whether SNe Ia are significantly affected by evolutionary effects.

Theoretical Clues to the Ultraviolet Diversity of Type Ia Supernovae

Science.gov (United States)

Brown, Peter J.; Baron, E.; Milne, Peter; Roming, Peter W. A.; Wang, Lifan

2015-08-01

The effect of metallicity on the observed light of Type Ia supernovae (SNe Ia) could lead to systematic errors as the absolute magnitudes of local and distant SNe Ia are compared to measure luminosity distances and determine cosmological parameters. The UV light may be especially sensitive to metallicity, though different modeling methods disagree as to the magnitude, wavelength dependence, and even the sign of the effect. The outer density structure, 56Ni, and to a lesser degree asphericity, also impact the UV. We compute synthetic photometry of various metallicity-dependent models and compare to UV/optical photometry from the Swift Ultra-Violet/Optical Telescope. We find that the scatter in the mid-UV to near-UV colors is larger than predicted by changes in metallicity alone and is not consistent with reddening. We demonstrate that a recently employed method to determine relative abundances using UV spectra can be done using UVOT photometry, but we warn that accurate results require an accurate model of the cause of the variations. The abundance of UV photometry now available should provide constraints on models that typically rely on UV spectroscopy for constraining metallicity, density, and other parameters. Nevertheless, UV spectroscopy for a variety of supernova explosions is still needed to guide the creation of accurate models. A better understanding of the influences affecting the UV is important for using SNe Ia as cosmological probes, as the UV light may test whether SNe Ia are significantly affected by evolutionary effects.

THEORETICAL CLUES TO THE ULTRAVIOLET DIVERSITY OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Brown, Peter J.; Wang, Lifan; Baron, E.; Milne, Peter; Roming, Peter W. A.

2015-01-01

The effect of metallicity on the observed light of Type Ia supernovae (SNe Ia) could lead to systematic errors as the absolute magnitudes of local and distant SNe Ia are compared to measure luminosity distances and determine cosmological parameters. The UV light may be especially sensitive to metallicity, though different modeling methods disagree as to the magnitude, wavelength dependence, and even the sign of the effect. The outer density structure, 56 Ni, and to a lesser degree asphericity, also impact the UV. We compute synthetic photometry of various metallicity-dependent models and compare to UV/optical photometry from the Swift Ultra-Violet/Optical Telescope. We find that the scatter in the mid-UV to near-UV colors is larger than predicted by changes in metallicity alone and is not consistent with reddening. We demonstrate that a recently employed method to determine relative abundances using UV spectra can be done using UVOT photometry, but we warn that accurate results require an accurate model of the cause of the variations. The abundance of UV photometry now available should provide constraints on models that typically rely on UV spectroscopy for constraining metallicity, density, and other parameters. Nevertheless, UV spectroscopy for a variety of supernova explosions is still needed to guide the creation of accurate models. A better understanding of the influences affecting the UV is important for using SNe Ia as cosmological probes, as the UV light may test whether SNe Ia are significantly affected by evolutionary effects

Phosphatase activity of Poa pratensis seeds. II. Purification and characterization of acid phosphatase Ia2 and Ia3

Directory of Open Access Journals (Sweden)

I. Lorenc-Kubis

2015-01-01

Full Text Available Two acid phosphatases (Ia2, Ia3 have been isolated from Poa pratensis seeds and partially purified. Both enzymes showed maximal activity at pH 4,9. They exhibited high activity towards p-nitrophenyl phosphate, inorganic pyrophosphate and phenyl phosphate, much less activity towards glucose-6 phosphate, and mononucleotides. Phosphatases a2 and a3 differed in their activity towards ADP. Orthophosphate, fluoride and Zn2+ were effective inhibitors. EDTA, β-mercaptoethanol and Mg2+ activated phophatase a2 but had no effect on phosphatase a3. Zn2+ inhibited the activity of phosphatase a2 noncompetitively, whereas phosphatase a3 showed inhibition of mixed type. Trypsin, chymotrypsin and pronase had no effect on the enzyme activities of both molecular forms.

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis

International Nuclear Information System (INIS)

Massa, P.T.; ter Meulen, V.; Fontana, A.

1987-01-01

In search of a phenotypic marker determining genetically controlled susceptibility to delayed-type hypersensitivity (DTH) reactions in the brain-in particular, experimental autoimmune encephalomyelitis (EAE)- the authors have compared the γ-interferon (IFN-γ) induction of Ia molecules on astrocytes and macrophages from rat and mouse strains that are susceptible or resistant to this disease. They focused on Ia expression because DTH reactions to self or foreign antigens are largely mediated by lymphocytes restricted by class II (Ia) antigens of the major histocompatibility complex (MHC). The data demonstrate that Lewis (fully susceptible) and Brown Norway (BN) (fully resistant) rats are very different in that Lewis astrocytes express much higher levels of Ia than BN astrocytes. Similar data were obtained from an analysis of EAE-susceptible and -resistant mouse strains (SJL and BALB/c, respectively), which suggest that this phenomenon may be universal and not limited to only one mammalian species. At least one gene responsible for Ia hyperinduction is located outside the rat RT-1 or the mouse MHC locus. Animals congenic at the RT-1 or MHC locus of the resistant strain but with background genes of the susceptible strain exhibit intermediate levels of Ia compared to fully resistant and susceptible rodents, which fits well with the reduced EAE susceptibility of these congenic animals. Furthermore, hyperinduction of Ia is astrocyte specific, since peritoneal macrophages of susceptible and resistant strains exhibit identical profiles of Ia induction. Thus, astrocyte Ia hyperinducibility may be a major strain- and tissue-specific factor that contributes to Ia-restricted DTH reactions in the brain

Type Ia Supernova Properties as a Function of the Distance to the Host Galaxy in the SDSS-II SN Survey

Energy Technology Data Exchange (ETDEWEB)

Galbany, Lluis [Institut de Fisica d' Altes Energies (IFAE), Barcelona (Spain); et al.

2012-08-20

We use type-Ia supernovae (SNe Ia) discovered by the SDSS-II SN Survey to search for dependencies between SN Ia properties and the projected distance to the host galaxy center, using the distance as a proxy for local galaxy properties (local star-formation rate, local metallicity, etc.). The sample consists of almost 200 spectroscopically or photometrically confirmed SNe Ia at redshifts below 0.25. The sample is split into two groups depending on the morphology of the host galaxy. We fit light-curves using both MLCS2k2 and SALT2, and determine color (AV, c) and light-curve shape (delta, x1) parameters for each SN Ia, as well as its residual in the Hubble diagram. We then correlate these parameters with both the physical and the normalized distances to the center of the host galaxy and look for trends in the mean values and scatters of these parameters with increasing distance. The most significant (at the 4-sigma level) finding is that the average fitted AV from MLCS2k2 and c from SALT2 decrease with the projected distance for SNe Ia in spiral galaxies. We also find indications that SNe in elliptical galaxies tend to have narrower light-curves if they explode at larger distances, although this may be due to selection effects in our sample. We do not find strong correlations between the residuals of the distance moduli with respect to the Hubble flow and the galactocentric distances, which indicates a limited correlation between SN magnitudes after standardization and local host metallicity.

Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock.

Directory of Open Access Journals (Sweden)

Mika Shapiro-Reznik

Full Text Available The neurexin genes (NRXN1/2/3 encode two families (α and β of highly polymorphic presynaptic proteins that are involved in excitatory/inhibitory synaptic balance. Recent studies indicate that neuronal activation and memory formation affect NRXN1/2/3α expression and alternative splicing at splice sites 3 and 4 (SS#3/SS#4. Neurons in the biological clock residing in the suprachiasmatic nuclei of the hypothalamus (SCN act as self-sustained oscillators, generating rhythms in gene expression and electrical activity, to entrain circadian bodily rhythms to the 24 hours day/night cycles. Cell autonomous oscillations in NRXN1/2/3α expression and SS#3/SS#4 exons splicing and their links to rhythms in excitatory/inhibitory synaptic balance in the circadian clock were explored. NRXN1/2/3α expression and SS#3/SS#4 splicing, levels of neurexin-2α and the synaptic scaffolding proteins PSD-95 and gephyrin (representing excitatory and inhibitory synapses, respectively were studied in mRNA and protein extracts obtained from SCN of C3H/J mice at different times of the 24 hours day/night cycle. Further studies explored the circadian oscillations in these components and causality relationships in immortalized rat SCN2.2 cells. Diurnal rhythms in mNRXN1α and mNRXN2α transcription, SS#3/SS#4 exon-inclusion and PSD-95 gephyrin and neurexin-2α levels were found in the SCN in vivo. No such rhythms were found with mNRXN3α. SCN2.2 cells also exhibited autonomous circadian rhythms in rNRXN1/2 expression SS#3/SS#4 exon inclusion and PSD-95, gephyrin and neurexin-2α levels. rNRXN3α and rNRXN1/2β were not expressed. Causal relationships were demonstrated, by use of specific siRNAs, between rNRXN2α SS#3 exon included transcripts and gephyrin levels in the SCN2.2 cells. These results show for the first time dynamic, cell autonomous, diurnal rhythms in expression and splicing of NRXN1/2 and subsequent effects on the expression of neurexin-2α and postsynaptic

Enhanced Excitatory Connectivity and Disturbed Sound Processing in the Auditory Brainstem of Fragile X Mice.

Science.gov (United States)

Garcia-Pino, Elisabet; Gessele, Nikodemus; Koch, Ursula

2017-08-02

Hypersensitivity to sounds is one of the prevalent symptoms in individuals with Fragile X syndrome (FXS). It manifests behaviorally early during development and is often used as a landmark for treatment efficacy. However, the physiological mechanisms and circuit-level alterations underlying this aberrant behavior remain poorly understood. Using the mouse model of FXS ( Fmr1 KO ), we demonstrate that functional maturation of auditory brainstem synapses is impaired in FXS. Fmr1 KO mice showed a greatly enhanced excitatory synaptic input strength in neurons of the lateral superior olive (LSO), a prominent auditory brainstem nucleus, which integrates ipsilateral excitation and contralateral inhibition to compute interaural level differences. Conversely, the glycinergic, inhibitory input properties remained unaffected. The enhanced excitation was the result of an increased number of cochlear nucleus fibers converging onto one LSO neuron, without changing individual synapse properties. Concomitantly, immunolabeling of excitatory ending markers revealed an increase in the immunolabeled area, supporting abnormally elevated excitatory input numbers. Intrinsic firing properties were only slightly enhanced. In line with the disturbed development of LSO circuitry, auditory processing was also affected in adult Fmr1 KO mice as shown with single-unit recordings of LSO neurons. These processing deficits manifested as an increase in firing rate, a broadening of the frequency response area, and a shift in the interaural level difference function of LSO neurons. Our results suggest that this aberrant synaptic development of auditory brainstem circuits might be a major underlying cause of the auditory processing deficits in FXS. SIGNIFICANCE STATEMENT Fragile X Syndrome (FXS) is the most common inheritable form of intellectual impairment, including autism. A core symptom of FXS is extreme sensitivity to loud sounds. This is one reason why individuals with FXS tend to avoid social

Premaximum observations of the type Ia SN 1990N

International Nuclear Information System (INIS)

Leibundgut, B.; Kirshner, R.P.; Filippenko, A.V.; Shields, J.C.; Foltz, C.B.; Phillips, M.M.; Sonneborn, G.

1991-01-01

Spectroscopic and photometric observations of SN 1990N were obtained at ultraviolet and optical wavelengths, beginning 14 days before maximum light. The early observations reveal important differences from spectra of SN Ia's around maximum light. Photometry and spectroscopy obtained after maximum show that SN 1990N is a typical SN Ia and that most of the observed differences are due to the early epoch of the observations. The most significant characteristics are (1) the high velocities of Ca and Si up to 22,000 km/s; (2) the presence of Co and Fe 2 weeks before maximum; and (3) the more rapid increase in the UV flux compared to the optical. The most popular models for white dwarf deflagration that have provided the standard interpretation for SN Ia's at maximum light do not reproduce the high velocities of Ca II and Si II lines observed in SN 1990N. 37 refs

Single Degenerate Models for Type Ia Supernovae: Progenitor's Evolution and Nucleosynthesis Yields

Science.gov (United States)

Nomoto, Ken'ichi; Leung, Shing-Chi

2018-06-01

We review how the single degenerate models for Type Ia supernovae (SNe Ia) works. In the binary star system of a white dwarf (WD) and its non-degenerate companion star, the WD accretes either hydrogen-rich matter or helium and undergoes hydrogen and helium shell-burning. We summarize how the stability and non-linear behavior of such shell-burning depend on the accretion rate and the WD mass and how the WD blows strong wind. We identify the following evolutionary routes for the accreting WD to trigger a thermonuclear explosion. Typically, the accretion rate is quite high in the early stage and gradually decreases as a result of mass transfer. With decreasing rate, the WD evolves as follows: (1) At a rapid accretion phase, the WD increase its mass by stable H burning and blows a strong wind to keep its moderate radius. The wind is strong enough to strip a part of the companion star's envelope to control the accretion rate and forms circumstellar matter (CSM). If the WD explodes within CSM, it is observed as an "SN Ia-CSM". (X-rays emitted by the WD are absorbed by CSM.) (2) If the WD continues to accrete at a lower rate, the wind stops and an SN Ia is triggered under steady-stable H shell-burning, which is observed as a super-soft X-ray source: "SN Ia-SSXS". (3) If the accretion continues at a still lower rate, H shell-burning becomes unstable and many flashes recur. The WD undergoes recurrent nova (RN) whose mass ejection is smaller than the accreted matter. Then the WD evolves to an "SN Ia-RN". (4) If the companion is a He star (or a He WD), the accretion of He can trigger He and C double detonations at the sub-Chandrasekhar mass or the WD grows to the Chandrasekhar mass while producing a He-wind: "SN Ia-He CSM". (5) If the accreting WD rotates quite rapidly, the WD mass can exceed the Chandrasekhar mass of the spherical WD, which delays the trigger of an SN Ia. After angular momentum is lost from the WD, the (super-Chandra) WD contracts to become a delayed SN Ia

The WD+He star binaries as the progenitors of type Ia supernovae

Directory of Open Access Journals (Sweden)

Wang Bo

2017-12-01

Full Text Available Employing the MESA stellar evolution code, we computed He accretion onto carbon-oxygen white dwarfs (CO WDs.We found two possible outcomes for models in which the WD steadily grows in mass towards the Chandrasekhar limit. For relatively low He-accretion rates carbon ignition occurs in the center, leading to a type Ia supernova (SN Ia explosion, whereas for relatively high accretion rates carbon is ignited off-center, probably leading to collapse. Thus the parameter space producing SNe Ia is reduced compared to what was assumed in earlier papers, in which the possibility of off-center ignition was ignored. We then applied these results in binary population synthesis modelling, finding a modest reduction in the expected birthrate of SNe Ia resulting from the WD+He star channel.

The influence of single bursts vs. single spikes at excitatory dendrodendritic synapses

Science.gov (United States)

Masurkar, Arjun V.; Chen, Wei R.

2015-01-01

The synchronization of neuronal activity is thought to enhance information processing. There is much evidence supporting rhythmically bursting external tufted cells (ETCs) of the rodent olfactory bulb glomeruli coordinating the activation of glomerular interneurons and mitral cells via dendrodendritic excitation. However, as bursting has variable significance at axodendritic cortical synapses, it is not clear if ETC bursting imparts a specific functional advantage over the preliminary spike in dendrodendritic synaptic networks. To answer this question, we investigated the influence of single ETC bursts and spikes with the in-vitro rat olfactory bulb preparation at different levels of processing, via calcium imaging of presynaptic ETC dendrites, dual electrical recording of ETC–interneuron synaptic pairs, and multicellular calcium imaging of ETC-induced population activity. Our findings supported single ETC bursts, vs. single spikes, driving robust presynaptic calcium signaling, which in turn was associated with profound extension of the initial monosynaptic spike-driven dendrodendritic excitatory postsynaptic potential. This extension could be driven by either the spike-dependent or spike-independent components of the burst. At the population level, burst-induced excitation was more widespread and reliable compared with single spikes. This further supports the ETC network, in part due to a functional advantage of bursting at excitatory dendrodendritic synapses, coordinating synchronous activity at behaviorally relevant frequencies related to odor processing in vivo. PMID:22277089

Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis?

OpenAIRE

Dienel, Gerald A.

2013-01-01

Astrocytic energetics of excitatory neurotransmission is controversial due to discrepant findings in different experimental systems in vitro and in vivo. The energy requirements of glutamate uptake are believed by some researchers to be satisfied by glycolysis coupled with shuttling of lactate to neurons for oxidation. However, astrocytes increase glycogenolysis and oxidative metabolism during sensory stimulation in vivo, indicating that other sources of energy are used by astrocytes during b...

Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms

OpenAIRE

Ting, Jonathan T.; Kelley, Brooke G.; Lambert, Talley J.; Cook, David G.; Sullivan, Jane M.

2006-01-01

Overexpression of the amyloid precursor protein (APP) in hippocampal neurons leads to elevated β-amyloid peptide (Aβ) production and consequent depression of excitatory transmission. The precise mechanisms underlying APP-induced synaptic depression are poorly understood. Uncovering these mechanisms could provide insight into how neuronal function is compromised before cell death during the early stages of Alzheimer's disease. Here we verify that APP up-regulation leads to depression of transm...

"Type Ia Supernovae: Tools for Studying Dark Energy" Final Technical Report

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Woosley, Stan [Lick Observatory, San Jose, CA (United States); Kasen, Dan [Univ. of California, Berkeley, CA (United States)

2017-05-10

Final technical report for project "Type Ia Supernovae: Tools for the Study of Dark Energy" awarded jointly to scientists at the University of California, Santa Cruz and Berkeley, for computer modeling, theory and data analysis relevant to the use of Type Ia supernovae as standard candles for cosmology.

THE EFFECT OF HOST GALAXIES ON TYPE Ia SUPERNOVAE IN THE SDSS-II SUPERNOVA SURVEY

International Nuclear Information System (INIS)

Lampeitl, Hubert; Smith, Mathew; Nichol, Robert C.; Bassett, Bruce; Cinabro, David; Dilday, Benjamin; Jha, Saurabh W.; Foley, Ryan J.; Frieman, Joshua A.; Garnavich, Peter M.; Goobar, Ariel; Nordin, Jakob; Im, Myungshin; Marriner, John; Miquel, Ramon; Oestman, Linda; Riess, Adam G.; Sako, Masao; Schneider, Donald P.; Sollerman, Jesper

2010-01-01

We present an analysis of the host galaxy dependences of Type Ia Supernovae (SNe Ia) from the full three year sample of the SDSS-II Supernova Survey. We re-discover, to high significance, the strong correlation between host galaxy type and the width of the observed SN light curve, i.e., fainter, quickly declining SNe Ia favor passive host galaxies, while brighter, slowly declining Ia's favor star-forming galaxies. We also find evidence (at between 2σ and 3σ) that SNe Ia are ≅0.1 ± 0.04 mag brighter in passive host galaxies than in star-forming hosts, after the SN Ia light curves have been standardized using the light-curve shape and color variations. This difference in brightness is present in both the SALT2 and MCLS2k2 light-curve fitting methodologies. We see evidence for differences in the SN Ia color relationship between passive and star-forming host galaxies, e.g., for the MLCS2k2 technique, we see that SNe Ia in passive hosts favor a dust law of R V = 1.0 ± 0.2, while SNe Ia in star-forming hosts require R V = 1.8 +0.2 -0.4 . The significance of these trends depends on the range of SN colors considered. We demonstrate that these effects can be parameterized using the stellar mass of the host galaxy (with a confidence of >4σ) and including this extra parameter provides a better statistical fit to our data. Our results suggest that future cosmological analyses of SN Ia samples should include host galaxy information.

A statistically self-consistent type Ia supernova data analysis

International Nuclear Information System (INIS)

Lago, B.L.; Calvao, M.O.; Joras, S.E.; Reis, R.R.R.; Waga, I.; Giostri, R.

2011-01-01

Full text: The type Ia supernovae are one of the main cosmological probes nowadays and are used as standardized candles in distance measurements. The standardization processes, among which SALT2 and MLCS2k2 are the most used ones, are based on empirical relations and leave room for a residual dispersion in the light curves of the supernovae. This dispersion is introduced in the chi squared used to fit the parameters of the model in the expression for the variance of the data, as an attempt to quantify our ignorance in modeling the supernovae properly. The procedure used to assign a value to this dispersion is statistically inconsistent and excludes the possibility of comparing different cosmological models. In addition, the SALT2 light curve fitter introduces parameters on the model for the variance that are also used in the model for the data. In the chi squared statistics context the minimization of such a quantity yields, in the best case scenario, a bias. An iterative method has been developed in order to perform the minimization of this chi squared but it is not well grounded, although it is used by several groups. We propose an analysis of the type Ia supernovae data that is based on the likelihood itself and makes it possible to address both inconsistencies mentioned above in a straightforward way. (author)

Pathway and Cell-Specific Kappa-Opioid Receptor Modulation of Excitatory-Inhibitory Balance Differentially Gates D1 and D2 Accumbens Neuron Activity

Science.gov (United States)

Tejeda, Hugo A.; Wu, Jocelyn; Kornspun, Alana R.; Pignatelli, Marco; Kashtelyan, Vadim; Krashes, Michael J.; Lowell, Brad B.; Carlezon, William A.; Bonci, Antonello

2018-01-01

Endogenous dynorphin signaling via the kappa-opioid receptor (KOR) in the nucleus accumbens (NAcc) powerfully mediates negative affective states and stress reactivity. Excitatory inputs from the hippocampus and amygdala play a fundamental role in shaping the activity of both NAcc D1 and D2 MSNs, which encode positive and negative motivational valences, respectively. However, a circuit-based mechanism by which KOR modulation of excitation-inhibition balance modifies D1 and D2 MSN activity is lacking. Here, we provide a comprehensive synaptic framework wherein presynaptic KOR inhibition decreases excitatory drive of D1 MSN activity by the amygdala, but not hippocampus. Conversely, presynaptic inhibition by KORs of inhibitory synapses on D2 MSNs enhances integration of excitatory drive by the amygdala and hippocampus. In conclusion, we describe a circuit-based mechanism showing differential gating of afferent control of D1 and D2 MSN activity by KORs in a pathway specific manner. PMID:28056342

Calibrating the Type Ia Supernova Distance Scale Using Surface Brightness Fluctuations

Science.gov (United States)

Potter, Cicely; Jensen, Joseph B.; Blakeslee, John; Milne, Peter; Garnavich, Peter M.; Brown, Peter

2018-06-01

We have observed 20 supernova host galaxies with HST WFC3/IR in the F110W filter, and prepared the data for Surface Brightness Fluctuation (SBF) distance measurements. The purpose of this study is to determine if there are any discrepancies between the SBF distance scale and the type-Ia SN distance scale, for which local calibrators are scarce. We have now measured SBF magnitudes to all early-type galaxies that have hosted SN Ia within 80 Mpc for which SBF measurements are possible. SBF is the only distance measurement technique with statistical uncertainties comparable to SN Ia that can be applied to galaxies out to 80 Mpc.

SN 2006bt: A PERPLEXING, TROUBLESOME, AND POSSIBLY MISLEADING TYPE Ia SUPERNOVA

International Nuclear Information System (INIS)

Foley, Ryan J.; Narayan, Gautham; Challis, Peter J.; Kirshner, Robert P.; Filippenko, Alexei V.; Silverman, Jeffrey M.; Steele, Thea N.

2010-01-01

SN 2006bt displays characteristics unlike those of any other known Type Ia supernova (SN Ia). We present optical light curves and spectra of SN 2006bt which demonstrate the peculiar nature of this object. SN 2006bt has broad, slowly declining light curves indicative of a hot, high-luminosity SN, but lacks a prominent second maximum in the i band as do low-luminosity SNe Ia. Its spectra are similar to those of low-luminosity SNe Ia, containing features that are only present in cool SN photospheres. Light-curve fitting methods suggest that SN 2006bt is reddened by a significant amount of dust; however, it occurred in the outskirts of its early-type host galaxy and has no strong Na D absorption in any of its spectra, suggesting a negligible amount of host-galaxy dust absorption. C II is possibly detected in our pre-maximum spectra, but at a much lower velocity than other elements. The progenitor was likely very old, being a member of the halo population of a galaxy that shows no signs of recent star formation. SNe Ia have been very successfully modeled as a one-parameter family, and this is fundamental to their use as cosmological distance indicators. SN 2006bt is a challenge to that picture, yet its relatively normal light curves allowed SN 2006bt to be included in cosmological analyses. We generate mock SN Ia data sets which indicate that contamination by similar objects will both increase the scatter of a SN Ia Hubble diagram and systematically bias measurements of cosmological parameters. However, spectra and rest-frame i-band light curves should provide a definitive way to identify and eliminate such objects.

Genetic algorithms and supernovae type Ia analysis

International Nuclear Information System (INIS)

Bogdanos, Charalampos; Nesseris, Savvas

2009-01-01

We introduce genetic algorithms as a means to analyze supernovae type Ia data and extract model-independent constraints on the evolution of the Dark Energy equation of state w(z) ≡ P DE /ρ DE . Specifically, we will give a brief introduction to the genetic algorithms along with some simple examples to illustrate their advantages and finally we will apply them to the supernovae type Ia data. We find that genetic algorithms can lead to results in line with already established parametric and non-parametric reconstruction methods and could be used as a complementary way of treating SNIa data. As a non-parametric method, genetic algorithms provide a model-independent way to analyze data and can minimize bias due to premature choice of a dark energy model

Employee benefits under IAS/IFRS and the Czech accounting legislation, the tax point of view including

Directory of Open Access Journals (Sweden)

Milena Otavová

2009-01-01

Full Text Available The regulation of employee benefit is limited in the Czech Accounting Legislation. There are only short-term employee benefits – wages, salaries, when employees has rendered services to an entity during a period – month. Entities could create funds from a net profit –fund for social and cultural benefits which could serve as source of social services financing for employees. There are employee benefits defined very extensive in IAS/IFRS. It is IAS 19 – Employee Benefits which defines four Gross of employee benefits: short-term employee benefits, post employment benefits, other long –term employee benefits and termination benefits. There are defined all conditions for employee benefits re­co­gni­tion and treatments for recording and reporting in IAS 19.The paper is concerned with the employee benefits evaluation. The impact on the tax base is eva­lua­ted. There are the most significant types of employee benefits surveyed. They are divided into five groups with the respect to their impact on the tax base. The impact of these benefits is described from their impact on social insurance and health insurance calculation base point of view, as well.

The Host Galaxies of Type Ia Supernovae Discovered by the Palomar Transient Factory

Science.gov (United States)

Pan, Y.-C.; Sullivan, M.; McGuire, K.; Hook, I. M.; Nugent, P. E.; Howell, D. A.; Arcavi, I.; Botyanszki, J.; Cenko, Stephen Bradley; DeRose, J.

2013-01-01

We present spectroscopic observations of the host galaxies of 82 low-redshift type Ia supernovae (SNe Ia) discovered by the Palomar Transient Factory (PTF). We determine star-formation rates, gas-phase stellar metallicities, and stellar masses and ages of these objects. As expected, strong correlations between the SN Ia light-curve width (stretch) and the host age mass metallicity are found: fainter, faster-declining events tend to be hosted by older massive metal-rich galaxies. There is some evidence that redder SNe Ia explode in higher metallicity galaxies, but we found no relation between the SN colour and host galaxy extinction based on the Balmer decrement, suggesting that the colour variation of these SNe does not primarily arise from this source. SNe Ia in higher-mass metallicity galaxies also appear brighter after stretch colour corrections than their counterparts in lower mass hosts, and the stronger correlation is with gas-phase metallicity suggesting this may be the more important variable. We also compared the host stellar mass distribution to that in galaxy targeted SN surveys and the high-redshift untargeted Supernova Legacy Survey (SNLS). SNLS has many more low mass galaxies, while the targeted searches have fewer. This can be explained by an evolution in the galaxy stellar mass function, coupled with a SN delay-time distribution proportional to t1. Finally, we found no significant difference in the mass--metallicity relation of our SN Ia hosts compared to field galaxies, suggesting any metallicity effect on the SN Ia rate is small.

Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity.

Science.gov (United States)

Tsai, Kuo-Ting; Hu, Chin-Kun; Li, Kuan-Wei; Hwang, Wen-Liang; Chou, Ya-Hui

2018-05-23

Local interneurons (LNs) in the Drosophila olfactory system exhibit neuronal diversity and variability, yet it is still unknown how these features impact information encoding capacity and reliability in a complex LN network. We employed two strategies to construct a diverse excitatory-inhibitory neural network beginning with a ring network structure and then introduced distinct types of inhibitory interneurons and circuit variability to the simulated network. The continuity of activity within the node ensemble (oscillation pattern) was used as a readout to describe the temporal dynamics of network activity. We found that inhibitory interneurons enhance the encoding capacity by protecting the network from extremely short activation periods when the network wiring complexity is very high. In addition, distinct types of interneurons have differential effects on encoding capacity and reliability. Circuit variability may enhance the encoding reliability, with or without compromising encoding capacity. Therefore, we have described how circuit variability of interneurons may interact with excitatory-inhibitory diversity to enhance the encoding capacity and distinguishability of neural networks. In this work, we evaluate the effects of different types and degrees of connection diversity on a ring model, which may simulate interneuron networks in the Drosophila olfactory system or other biological systems.

Up-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by ß-Klotho

Directory of Open Access Journals (Sweden)

Jamshed Warsi

2015-12-01

Full Text Available Background/Aims: Klotho, a transmembrane protein expressed in chorioid plexus of the brain, kidney, and several other tissues, is required for inhibition of 1,25(OH2D3 formation by FGF23. The extracellular domain of Klotho protein could be cleaved off, thus being released into blood or cerebrospinal fluid. At least in part by exerting β-glucuronidase activity, soluble klotho regulates several ion channels and carriers. Klotho protein deficiency accelerates the appearance of age related disorders including neurodegeneration and muscle wasting and eventually leads to premature death. The present study explored the effect of Klotho protein on the excitatory glutamate transporters EAAT1 (SLC1A3 and EAAT2 (SLC1A2, Na+ coupled carriers clearing excitatory amino acids from the synaptic cleft and thus participating in the regulation of neuronal excitability. Methods: cRNA encoding EAAT1 or EAAT2 was injected into Xenopus laevis oocytes and glutamate (2 mM-induced inward current (IGlu taken as measure of glutamate transport. Measurements were made without or with prior 24 h treatment with soluble ß-Klotho protein (30 ng/ml in the absence and presence of β-glucuronidase inhibitor D-saccharic acid 1,4-lactone monohydrate (DSAL,10 µM. Results: IGlu was observed in EAAT1 and in EAAT2 expressing oocytes but not in water injected oocytes. In both, EAAT1 and EAAT2 expressing oocytes IGlu was significantly increased by treatment with soluble ß-Klotho protein, an effect reversed by DSAL. Treatment with ß-klotho protein increased significantly the maximal transport rate without significantly modifying the affinity of the carriers. Conclusion: ß-Klotho up-regulates the excitatory glutamate transporters EAAT1 and EAAT2 and thus participates in the regulation of neuronal excitation.

SURF IA Conflict Detection and Resolution Algorithm Evaluation

Science.gov (United States)

Jones, Denise R.; Chartrand, Ryan C.; Wilson, Sara R.; Commo, Sean A.; Barker, Glover D.

2012-01-01

The Enhanced Traffic Situational Awareness on the Airport Surface with Indications and Alerts (SURF IA) algorithm was evaluated in a fast-time batch simulation study at the National Aeronautics and Space Administration (NASA) Langley Research Center. SURF IA is designed to increase flight crew situation awareness of the runway environment and facilitate an appropriate and timely response to potential conflict situations. The purpose of the study was to evaluate the performance of the SURF IA algorithm under various runway scenarios, multiple levels of conflict detection and resolution (CD&R) system equipage, and various levels of horizontal position accuracy. This paper gives an overview of the SURF IA concept, simulation study, and results. Runway incursions are a serious aviation safety hazard. As such, the FAA is committed to reducing the severity, number, and rate of runway incursions by implementing a combination of guidance, education, outreach, training, technology, infrastructure, and risk identification and mitigation initiatives [1]. Progress has been made in reducing the number of serious incursions - from a high of 67 in Fiscal Year (FY) 2000 to 6 in FY2010. However, the rate of all incursions has risen steadily over recent years - from a rate of 12.3 incursions per million operations in FY2005 to a rate of 18.9 incursions per million operations in FY2010 [1, 2]. The National Transportation Safety Board (NTSB) also considers runway incursions to be a serious aviation safety hazard, listing runway incursion prevention as one of their most wanted transportation safety improvements [3]. The NTSB recommends that immediate warning of probable collisions/incursions be given directly to flight crews in the cockpit [4].

Elemental gas-phase abundances of intermediate redshift type Ia supernova star-forming host galaxies

Science.gov (United States)

Moreno-Raya, M. E.; Galbany, L.; López-Sánchez, Á. R.; Mollá, M.; González-Gaitán, S.; Vílchez, J. M.; Carnero, A.

2018-05-01

The maximum luminosity of type Ia supernovae (SNe Ia) depends on the oxygen abundance of the regions of the host galaxies, where they explode. This metallicity dependence reduces the dispersion in the Hubble diagram (HD) when included with the traditional two-parameter calibration of SN Ia light-curve parameters and absolute magnitude. In this work, we use empirical calibrations to carefully estimate the oxygen abundance of galaxies hosting SNe Ia from the SDSS-II/SN (Sloan Digital Sky Survey-II Supernova) survey at intermediate redshift by measuring their emission-line intensities. We also derive electronic temperature with the direct method for a small fraction of objects for consistency. We find a trend of decreasing oxygen abundance with increasing redshift for the most massive galaxies. Moreover, we study the dependence of the HD residuals (HR) with galaxy oxygen abundance obtaining a correlation in line with those found in other works. In particular, the HR versus oxygen abundance shows a slope of -0.186 ± 0.123 mag dex-1 (1.52σ) in good agreement with theoretical expectations. This implies smaller distance modulii after corrections for SNe Ia in metal-rich galaxies. Based on our previous results on local SNe Ia, we propose this dependence to be due to the lower luminosity of the SNe Ia produced in more metal-rich environments.

77 FR 50155 - Neal Smith National Wildlife Refuge, Jasper County, IA

Science.gov (United States)

2012-08-20

... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R3-R-2012-N119; FXRS1265030000S3-123-FF03R06000] Neal Smith National Wildlife Refuge, Jasper County, IA AGENCY: Fish and Wildlife Service... 399, 9981 Pacific Street, Prairie City, IA 50228. In-Person Drop Off: You may drop off comments during...

ON THE DEPENDENCE OF TYPE Ia SNe LUMINOSITIES ON THE METALLICITY OF THEIR HOST GALAXIES

International Nuclear Information System (INIS)

Moreno-Raya, Manuel E.; Mollá, Mercedes; López-Sánchez, Ángel R.; Galbany, Lluís; Vílchez, José Manuel; Rosell, Aurelio Carnero; Domínguez, Inmaculada

2016-01-01

The metallicity of the progenitor system producing a type Ia supernova (SN Ia) could play a role in its maximum luminosity, as suggested by theoretical predictions. We present an observational study to investigate if such a relationship exists. Using the 4.2 m William Herschel Telescope (WHT) we have obtained intermediate-resolution spectroscopy data of a sample of 28 local galaxies hosting SNe Ia, for which distances have been derived using methods independent of those based on SN Ia parameters. From the emission lines observed in their optical spectra, we derived the gas-phase oxygen abundance in the region where each SN Ia exploded. Our data show a trend, with an 80% of chance not being due to random fluctuation, between SNe Ia absolute magnitudes and the oxygen abundances of the host galaxies, in the sense that luminosities tend to be higher for galaxies with lower metallicities. This result seems likely to be in agreement with both the theoretically expected behavior and with other observational results. This dependence M B –Z might induce systematic errors when it is not considered when deriving SNe Ia luminosities and then using them to derive cosmological distances

THE MEAN TYPE IA SUPERNOVA SPECTRUM OVER THE PAST NINE GIGAYEARS

International Nuclear Information System (INIS)

Sullivan, M.; Ellis, R. S.; Howell, D. A.; Riess, A.; Nugent, P. E.; Gal-Yam, A.

2009-01-01

We examine the possibility of evolution with redshift in the mean rest-frame ultraviolet (UV; λ ∼ H and Kand Mg II blends, indicating lower IME abundances in the higher redshift SNe. A larger fraction of luminous, wider light-curve width (higher s tretch ) SNe Ia are expected at higher redshift than locally, so we compare our observed spectral evolution with that predicted by a redshift-evolving stretch distribution coupled with a stretch-dependent SN Ia spectrum. We show that the sense of the spectral evolution can be reproduced by this simple model, though the highest redshift events seem additionally deficient in Si and Ca. We also examine the mean SN Ia UV-optical colors as a function of redshift, thought to be sensitive to variations in progenitor composition. We find that the expected stretch variations are sufficient to explain the differences, although improved data at z ∼ 0 will enable more precise tests. Thus, to the extent possible with the available data sets, our results support the continued use of SNe Ia as standardized candles.

Lupus nephritis: prolonged immunoadsorption (IAS) reduces proteinuria and stabilizes global disease activity.

Science.gov (United States)

Stummvoll, Georg H; Schmaldienst, Sabine; Smolen, Josef S; Derfler, Kurt; Biesenbach, Peter

2012-02-01

Systemic lupus erythematosus (SLE) is characterized by pathogenic autoantibodies, which can be removed by extracorporeal procedures. While previous studies have shown short-term efficacy of immunoadsorption (IAS) in SLE, no information on long-term benefit and safety is available. IAS was offered to patients with highly active renal disease when conventional therapy had failed. Eleven patients entered the prolonged IAS programme and were followed for up to 10 years (mean 6.4 ± 3.5). Efficacy of IAS was determined by reduction in proteinuria (primary outcome), global disease activity [SLE Disease Activity Index (SLEDAI)] and anti-double-stranded DNA (anti-dsDNA) levels (secondary outcomes). Full/partial remission was defined as ≤ 0.5/≤ 1.0 g/day for proteinuria, ≤ 5/≤ 8 for SLEDAI and ≤ 25/≤ 50 IU/mL for anti-dsDNA levels. We further assessed flares, infections, malignancies and procedure-related adverse events. Short-term IAS (≤ 1 year) resulted in a significant reduction of proteinuria (9.2 ± 3.7 to 2.3 ± 2.4, P = 0.0001), disease activity (SLEDAI 19 ± 8 to 4 ± 2, P = 0.0004) and dsDNA levels (168 ± 205 to 45 ± 34, P = 0.001). In patients without remission after 1 year (n = 5), prolonged IAS decreased proteinuria from 4.3 ± 2.4 to 0.5 ± 0.4 g/day, P = 0.02. At the end of observation, complete remission in proteinuria was achieved in seven patients (64%) and partial remission in two (18%) additional patients. One patient flared and was discontinued; in all other patients, disease activity and anti-dsDNA stabilized at remission levels. Flares (0.28 ± 0.30) and infections (0.66 ± 0.70 per patient/year) were relatively uncommon; no malignancies, anaphylactic or orthostatic adverse events were observed. IAS is effective in short-term use but prolonged IAS can provide additional therapeutic benefit while showing an acceptable safety profile. The vast majority of initially therapy-refractory patients met the remission criteria at the end of

EVOLUTION IN THE VOLUMETRIC TYPE Ia SUPERNOVA RATE FROM THE SUPERNOVA LEGACY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Perrett, K.; Gonzalez-Gaitan, S.; Carlberg, R. [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON, M5S 3H4 (Canada); Sullivan, M.; Hook, I. M. [Department of Physics (Astrophysics), University of Oxford, DWB, Keble Road, Oxford OX1 3RH (United Kingdom); Conley, A. [Center for Astrophysics and Space Astronomy, University of Colorado, 593 UCB, Boulder, CO 80309-0593 (United States); Fouchez, D. [CPPM, CNRS-IN2P3 and University Aix Marseille II, Case 907, 13288 Marseille cedex 9 (France); Ripoche, P. [Lawrence Berkeley National Laboratory, Mail Stop 50-232, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Neill, J. D. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, 1200 East California Blvd., Pasadena, CA 91125 (United States); Astier, P.; Balland, C.; Guy, J.; Hardin, D.; Pain, R.; Regnault, N. [LPNHE, Universite Pierre et Marie Curie Paris 6, Universite Paris Diderot Paris 7, CNRS-IN2P3, 4 place Jussieu, 75005 Paris (France); Balam, D. [Dominion Astrophysical Observatory, Herzberg Institute of Astrophysics, 5071 West Saanich Road, Victoria, BC, V9E 2E7 (Canada); Basa, S. [Laboratoire d' Astrophysique de Marseille, Pole de l' Etoile Site de Chateau-Gombert, 38, rue Frederic Joliot-Curie, 13388 Marseille cedex 13 (France); Howell, D. A. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Dr., Suite 102, Goleta, CA 93117 (United States); Palanque-Delabrouille, N. [DSM/IRFU/SPP, CEA-Saclay, F-91191 Gif-sur-Yvette (France); Pritchet, C., E-mail: perrett@astro.utoronto.ca, E-mail: sullivan@astro.ox.ac.uk [Department of Physics and Astronomy, University of Victoria, P.O. Box 3055, Stn CSC, Victoria, BC, V8W 3P6 (Canada); and others

2012-08-15

We present a measurement of the volumetric Type Ia supernova (SN Ia) rate (SNR{sub Ia}) as a function of redshift for the first four years of data from the Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS). This analysis includes 286 spectroscopically confirmed and more than 400 additional photometrically identified SNe Ia within the redshift range 0.1 {<=} z {<=} 1.1. The volumetric SNR{sub Ia} evolution is consistent with a rise to z {approx} 1.0 that follows a power law of the form (1+z){sup {alpha}}, with {alpha} = 2.11 {+-} 0.28. This evolutionary trend in the SNLS rates is slightly shallower than that of the cosmic star formation history (SFH) over the same redshift range. We combine the SNLS rate measurements with those from other surveys that complement the SNLS redshift range, and fit various simple SN Ia delay-time distribution (DTD) models to the combined data. A simple power-law model for the DTD (i.e., {proportional_to}t{sup -{beta}}) yields values from {beta} = 0.98 {+-} 0.05 to {beta} = 1.15 {+-} 0.08 depending on the parameterization of the cosmic SFH. A two-component model, where SNR{sub Ia} is dependent on stellar mass (M{sub stellar}) and star formation rate (SFR) as SNR{sub Ia}(z) = A Multiplication-Sign M{sub stellar}(z) + B Multiplication-Sign SFR(z), yields the coefficients A = (1.9 {+-} 0.1) Multiplication-Sign 10{sup -14} SNe yr{sup -1} M{sup -1}{sub Sun} and B = (3.3 {+-} 0.2) Multiplication-Sign 10{sup -4} SNe yr{sup -1} (M{sub Sun} yr{sup -1}){sup -1}. More general two-component models also fit the data well, but single Gaussian or exponential DTDs provide significantly poorer matches. Finally, we split the SNLS sample into two populations by the light-curve width (stretch), and show that the general behavior in the rates of faster-declining SNe Ia (0.8 {<=} s < 1.0) is similar, within our measurement errors, to that of the slower objects (1.0 {<=} s < 1.3) out to z {approx} 0.8.

Could there be a hole in type Ia supernovae?

International Nuclear Information System (INIS)

Kasen, Daniel; Nugent, Peter; Thomas, R.C.; Wang, Lifan

2004-01-01

In the favored progenitor scenario, Type Ia supernovae (SNe Ia) arise from a white dwarf accreting material from a non-degenerate companion star. Soon after the white dwarf explodes, the ejected supernova material engulfs the companion star; two-dimensional hydrodynamical simulations by Marietta et al. (2001) show that, in the interaction, the companion star carves out a conical hole of opening angle 30-40 degrees in the supernova ejecta. In this paper we use multi-dimensional Monte Carlo radiative transfer calculations to explore the observable consequences of an ejecta-hole asymmetry. We calculate the variation of the spectrum, luminosity, and polarization with viewing angle for the aspherical supernova near maximum light. We find that the supernova looks normal from almost all viewing angles except when one looks almost directly down the hole. In the latter case, one sees into the deeper, hotter layers of ejecta. The supernova is relatively brighter and has a peculiar spectrum characterized by more highly ionized species, weaker absorption features, and lower absorption velocities. The spectrum viewed down the hole is comparable to the class of SN 1991T-like supernovae. We consider how the ejecta-hole asymmetry may explain the current spectropolarimetric observations of SNe Ia, and suggest a few observational signatures of the geometry. Finally, we discuss the variety currently seen in observed SNe Ia and how an ejecta-hole asymmetry may fit in as one of several possible sources of diversity

Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia.

Science.gov (United States)

Farah, Benjamin L; Landau, Dustin J; Wu, Yajun; Sinha, Rohit A; Loh, Alwin; Bay, Boon-Huat; Koeberl, Dwight D; Yen, Paul M

2017-11-01

GSD Ia (von Gierke Disease, Glycogen Storage Disease Type Ia) is a devastating genetic disorder with long-term sequelae, such as non-alcoholic fatty liver disease and renal failure. Down-regulated autophagy is involved in the development of hepatic metabolic dysfunction in GSD Ia; however, the role of autophagy in the renal pathology is unknown. Here we show that autophagy is impaired and endoplasmic reticulum (ER) stress is increased in the kidneys of a mouse model of GSD Ia. Induction of autophagy by rapamycin also reduces this ER stress. Taken together, these results show an additional role for autophagy down-regulation in the pathogenesis of GSD Ia, and provide further justification for the use of autophagy modulators in GSD Ia. Copyright © 2017 Elsevier Inc. All rights reserved.

76 FR 54521 - Iowa Disaster #IA-00036

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2011-09-01

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12754 and 12755] Iowa Disaster IA-00036 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major [[Page 54522

Student Flow Model SFM-IA Reports. Technical Report 42. Preliminary Draft.

Science.gov (United States)

Western Interstate Commission for Higher Education, Boulder, CO. National Center for Higher Education Management Systems.

Examples of the reports generated by the National Center for Higher Education Management Systems (NCHEMS) Student Flow Model (SFM) IA are presented. The SFM-IA is a tool for analyzing the historical movement of students between the various fields of study and student levels in an institution and for estimating the future enrollments in each field…

Synchronization in a non-uniform network of excitatory spiking neurons

Science.gov (United States)

Echeveste, Rodrigo; Gros, Claudius

Spontaneous synchronization of pulse coupled elements is ubiquitous in nature and seems to be of vital importance for life. Networks of pacemaker cells in the heart, extended populations of southeast asian fireflies, and neuronal oscillations in cortical networks, are examples of this. In the present work, a rich repertoire of dynamical states with different degrees of synchronization are found in a network of excitatory-only spiking neurons connected in a non-uniform fashion. In particular, uncorrelated and partially correlated states are found without the need for inhibitory neurons or external currents. The phase transitions between these states, as well the robustness, stability, and response of the network to external stimulus are studied.

Type Ia supernovae in elliptical and spiral galaxies - Possible differences in photometric homogeneity

International Nuclear Information System (INIS)

Filippenko, A.V.

1989-01-01

It is shown that beta, the initial postmaximum rate of SN brightness decline (in the B band) defined by Pskovskii (1977), may have a smaller dispersion among SNe Ia in elliptical galaxies than in all other types of galaxies. Contamination of the sample by SNe Ib is unlikely to be the primary cause of this difference. Although the number of objects is very small, it is also possible that the velocity of SN Ia ejecta in elliptical galaxies is lower than in spiral galaxies. If correct, these observations provide the first direct evidence for physical differences among SNe Ia in different environments; reddening variations due to gas and dust are unlikely to produce most of the observed dispersion in beta among spirals. One obvious possibility is that the SNe Ia in spiral galaxies come from intermediate-mass stars, and that differences in the metallicities, accretion rates, or other properties account for the observations. A more extreme, improbable explanation is that not all SNe Ia in spiral galaxies result from carbon deflagrations of carbon-oxygen white dwarfs. 43 refs

Synthesis of opioid receptor imaging agent 7α-o-IA-DPN

International Nuclear Information System (INIS)

Wang Rongfu

1997-01-01

A new opioid receptor imaging agent is designed and synthesized. 7α-o-iodoallyl diprenorphine (7α-o-IA-DPN) was obtained in one step by radioiododestannylation, which involved in the selection of DPN as an opioid antagonist, the regioselective protection of the DPN phenol tertiary-OH using acetylation and the introduction of vinylstannane as prosthetic group into the tertiary alcohol group position in the 7α-side chain. The iodinated DPN derivation was possessed of high radiolabeled yield (>90%) with 80 TBq/mmol specific radioactivity and more than 95% radiochemical purity. In vitro opioid receptor binding analysis showed very high affinity (Ki = 0.4 nmol/L). This new radioiodinated opioid ligand is suitable for SPECT study of opioid receptor imaging

The Physics of Type Ia Supernova Light Curves. I. Analytic Results and Time Dependence

International Nuclear Information System (INIS)

Pinto, Philip A.; Eastman, Ronald G.

2000-01-01

We develop an analytic solution of the radiation transport problem for Type Ia supernovae (SNe Ia) and show that it reproduces bolometric light curves produced by more detailed calculations under the assumption of a constant-extinction coefficient. This model is used to derive the thermal conditions in the interior of SNe Ia and to study the sensitivity of light curves to various properties of the underlying supernova explosions. Although the model is limited by simplifying assumptions, it is adequate for demonstrating that the relationship between SNe Ia maximum-light luminosity and rate of decline is most easily explained if SNe Ia span a range in mass. The analytic model is also used to examine the size of various terms in the transport equation under conditions appropriate to maximum light. For instance, the Eulerian and advective time derivatives are each shown to be of the same order of magnitude as other order v/c terms in the transport equation. We conclude that a fully time-dependent solution to the transport problem is needed in order to compute SNe Ia light curves and spectra accurate enough to distinguish subtle differences of various explosion models. (c) 2000 The American Astronomical Society

Interaction between a "processed" ovalbumin peptide and Ia molecules

DEFF Research Database (Denmark)

Buus, S; Colon, S; Smith, C

1986-01-01

The binding of 125I-labeled immunogenic peptides to purified Ia molecules in detergent solution was examined by equilibrium dialysis. We used the chicken ovalbumin peptide ovalbumin-(323-339)-Tyr, which is immunogenic in the BALB/c mouse and restricted to I-Ad. 125I-labeled ovalbumin-(323-339)-Tyr......-Ak but not to I-Ek, I-Ad, or I-Ed. Thus, a specific interaction between Ia and antigen that correlates with the major histocompatibility complex restriction was demonstrated, strongly arguing in favor of a determinant selection hypothesis for such restriction....

Tillämpning av IAS 40 i onoterade fastighetsbolag

OpenAIRE

Wallin, Fredrik; Nilsson, Karolina; Ericsson, Marina

2006-01-01

Enligt IAS 40 – Förvaltningsfastigheter, definieras förvaltningsfastigheter som ”mark eller byggnader eller del av byggnad som innehas i syfte att generera hyresinkomster eller värdestegring”. Onoterade fastighetsbolag i Sverige har idag möjlighet att välja mellan att värdera sina fastigheter till anskaffningsvärde eller verkligt värde. IAS – International Accounting Standards är en internationell redovisningsstandard inom EU som började tillämpas i januari 2001, men blev obligatorisk för bör...

Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation.

Science.gov (United States)

Singh, Jagmohan; Kumar, Sumit; Krishna, Chadalavada Vijay; Rattan, Satish

2014-06-01

Internal anal sphincter (IAS) tone plays an important role in rectoanal incontinence (RI). IAS tone may be compromised during aging, leading to RI in certain patients. We examined the influence of oxidative stress in the aging-associated decrease in IAS tone (AADI). Using adult (4-6 mo old) and aging (24-30 mo old) rats, we determined the effect of oxidative stress on IAS tone and the regulatory RhoA/ROCK signal transduction cascade. We determined the effect of the oxidative stress inducer LY83583, which produces superoxide anions (O2 (·-)), on basal and stimulated IAS tone before and after treatment of intact smooth muscle strips and smooth muscle cells with the O2 (·-) scavenger SOD. Our data showed that AADI was associated with a decrease in RhoA/ROCK expression at the transcriptional and translational levels. Oxidative stress with a LY83583-mediated decrease in IAS tone and relaxation of IAS smooth muscle cells was associated with a decrease in RhoA/ROCK signal transduction, which was reversible by SOD. In addition, LY83583 caused a significant decrease in IAS contraction produced by the RhoA activator and a known RhoA/ROCK agonist, U46619, that was also reversible by SOD. The inhibitory effects of LY83583 and the ROCK inhibitor Y27632 on the U46619-induced increase in IAS tone were similar. We conclude that an increase in oxidative stress plays an important role in AADI in the elderly and may be one of the underlying mechanisms of RI in certain aging patients. Copyright © 2014 the American Physiological Society.

The T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated Ia

DEFF Research Database (Denmark)

Gay, D; Buus, S; Pasternak, J

1988-01-01

The membrane protein CD4 is commonly found on mature T cells specific for antigen in association with class II major histocompatibility complex (MHC; Ia) proteins. This correlation has led to the suggestion that CD4 binds to a monomorphic region of the Ia molecule on the antigen-presenting cell...... proteins into a planar membrane system, we show that different Ia molecules can greatly enhance the ability of a CD4+ but not a CD4- variant of this class I-restricted T hybrid to respond to isolated class I molecules. T-cell responses can be strongly augmented by the concurrent expression of CD4 on the T...... cell and any of four different Ia proteins on planar membranes, thus supporting the idea that CD4 binds to a monomorphic region of the Ia molecule and increases the avidity with which the T cell can interact with its target....

Asian patients with Hinchey Ia acute diverticulitis: a condition for the ambulatory setting?

Science.gov (United States)

Chan, Dedrick Kok Hong; Tan, Ker-Kan

2018-01-01

Diverticulitis in Asians is a different disease entity from Western counterparts. Few Asian studies have evaluated the management of acute Hinchey Ia diverticulitis with consideration for outpatient management. The purpose of this study was to evaluate the outcomes of Asian patients with Hinchey Ia acute diverticulitis. A retrospective review of all patients who were treated for Hinchey Ia acute colonic diverticulitis between 2012 and 2014 was performed. All patients were diagnosed on computed tomography (CT). There were 129 patients with Hinchey Ia acute diverticulitis. Fifty-five (42.6%) patients were male, and the median age was 54 years (range, 30-86). Eighty-seven (67.4%) patients had right-sided diverticulitis. Most patients were treated empirically with intravenous ceftriaxone and metronidazole (89.1%). They were then discharged with oral antibiotics. Only 6.1% of patients had a positive blood culture. The median length of stay in the hospital was 4 (range, 3-4) days. Only three (2.3%) patients were readmitted for acute diverticulitis within 30 days. They were managed with antibiotics and discharged well. The repeated CT scans reconfirmed Hinchey Ia diverticulitis. No patients required emergency surgery, and there were no 30-day mortalities. Asian patients with Hinchey Ia diverticulitis recovered well with conservative management and could be amenable to outpatient therapy. Future prospective studies should be performed amongst Asians to evaluate managing this condition in an ambulatory setting.

Tension between SNeIa and BAO: current status and future forecasts

Energy Technology Data Exchange (ETDEWEB)

Escamilla-Rivera, Celia [Astrophysics, University of Oxford, DWD, Kebble Road, Oxford, OX1 3RH (United Kingdom); Lazkoz, Ruth; Salzano, Vincenzo; Sendra, Irene, E-mail: celia_escamilla@ehu.es, E-mail: ruth.lazkoz@ehu.es, E-mail: vincenzo.salzano@ehu.es, E-mail: irene.sendra@ehu.es [Fisika Teorikoaren eta Zientziaren Historia Saila, Zientzia eta Teknologia Fakultatea, Euskal Herriko Unibertsitatea, 644 Posta Kutxatila, 48080 Bilbao (Spain)

2011-09-01

Using real and synthetic Type Ia SNe (SNeIa) and baryon acoustic oscillations (BAO) data representing current observations forecasts, this paper investigates the tension between those probes in the dark energy equation of state (EoS) reconstruction considering the well known CPL model and Wang's low correlation reformulation. In particular, here we present simulations of BAO data from both the the radial and transverse directions. We also explore the influence of priors on Ω{sub m} and Ω{sub b} on the tension issue, by considering 1σ deviations in either one or both of them. Our results indicate that for some priors there is no tension between a single dataset (either SNeIa or BAO) and their combination (SNeIa+BAO). Our criterion to discern the existence of tension (σ-distance) is also useful to establish which is the dataset with most constraining power; in this respect SNeIa and BAO data switch roles when current and future data are considered, as forecasts predict and spectacular quality improvement on BAO data. We also find that the results on the tension are blind to the way the CPL model is addressed: there is a perfect match between the original formulation and that by the correlation optimized proposed in Wang (2008), but the errors on the parameters are much narrower in all cases of our exhaustive exploration, thus serving the purpose of stressing the convenience of this reparametrization.

EVIDENCE FOR ASYMMETRIC DISTRIBUTION OF CIRCUMSTELLAR MATERIAL AROUND TYPE Ia SUPERNOVAE

Energy Technology Data Exchange (ETDEWEB)

Foerster, Francisco; Gonzalez-Gaitan, Santiago; Anderson, Joseph; Marchi, Sebastian; Gutierrez, Claudia; Hamuy, Mario; Cartier, Regis [Departamento de Astronomia, Universidad de Chile, Casilla 36-D, Santiago (Chile); Pignata, Giuliano [Departamento Ciencias Fisicas, Universidad Andres Bello, Av. Republica 252, Santiago (Chile)

2012-08-01

We study the properties of low-velocity material in the line of sight toward nearby Type Ia supernovae (SNe Ia) that have measured late phase nebular velocity shifts (v{sub neb}), thought to be an environment-independent observable. We have found that the distribution of equivalent widths of narrow blended Na I D1 and D2 and Ca II H and K absorption lines differs significantly between those SNe Ia with negative and positive v{sub neb}, with generally stronger absorption for SNe Ia with v{sub neb} {>=} 0. A similar result had been found previously for the distribution of colors of SNe Ia, which was interpreted as a dependence of the temperature of the ejecta with viewing angle. Our work suggests that (1) a significant part of these differences in color should be attributed to extinction, (2) this extinction is caused by an asymmetric distribution of circumstellar material (CSM), and (3) the CSM absorption is generally stronger on the side of the ejecta opposite to where the ignition occurs. Since it is difficult to explain (3) via any known physical processes that occur before explosion, we argue that the asymmetry of the CSM is originated after explosion by a stronger ionizing flux on the side of the ejecta where ignition occurs, probably due to a stronger shock breakout and/or more exposed radioactive material on one side of the ejecta. This result has important implications for both progenitor and explosion models.

Tension between SNeIa and BAO: current status and future forecasts

International Nuclear Information System (INIS)

Escamilla-Rivera, Celia; Lazkoz, Ruth; Salzano, Vincenzo; Sendra, Irene

2011-01-01

Using real and synthetic Type Ia SNe (SNeIa) and baryon acoustic oscillations (BAO) data representing current observations forecasts, this paper investigates the tension between those probes in the dark energy equation of state (EoS) reconstruction considering the well known CPL model and Wang's low correlation reformulation. In particular, here we present simulations of BAO data from both the the radial and transverse directions. We also explore the influence of priors on Ω m and Ω b on the tension issue, by considering 1σ deviations in either one or both of them. Our results indicate that for some priors there is no tension between a single dataset (either SNeIa or BAO) and their combination (SNeIa+BAO). Our criterion to discern the existence of tension (σ-distance) is also useful to establish which is the dataset with most constraining power; in this respect SNeIa and BAO data switch roles when current and future data are considered, as forecasts predict and spectacular quality improvement on BAO data. We also find that the results on the tension are blind to the way the CPL model is addressed: there is a perfect match between the original formulation and that by the correlation optimized proposed in Wang (2008), but the errors on the parameters are much narrower in all cases of our exhaustive exploration, thus serving the purpose of stressing the convenience of this reparametrization

Research on Segmentation Monitoring Control of IA-RWA Algorithm with Probe Flow

Science.gov (United States)

Ren, Danping; Guo, Kun; Yao, Qiuyan; Zhao, Jijun

2018-04-01

The impairment-aware routing and wavelength assignment algorithm with probe flow (P-IA-RWA) can make an accurate estimation for the transmission quality of the link when the connection request comes. But it also causes some problems. The probe flow data introduced in the P-IA-RWA algorithm can result in the competition for wavelength resources. In order to reduce the competition and the blocking probability of the network, a new P-IA-RWA algorithm with segmentation monitoring-control mechanism (SMC-P-IA-RWA) is proposed. The algorithm would reduce the holding time of network resources for the probe flow. It segments the candidate path suitably for the data transmitting. And the transmission quality of the probe flow sent by the source node will be monitored in the endpoint of each segment. The transmission quality of data can also be monitored, so as to make the appropriate treatment to avoid the unnecessary probe flow. The simulation results show that the proposed SMC-P-IA-RWA algorithm can effectively reduce the blocking probability. It brings a better solution to the competition for resources between the probe flow and the main data to be transferred. And it is more suitable for scheduling control in the large-scale network.

The influence of single bursts versus single spikes at excitatory dendrodendritic synapses.

Science.gov (United States)

Masurkar, Arjun V; Chen, Wei R

2012-02-01

The synchronization of neuronal activity is thought to enhance information processing. There is much evidence supporting rhythmically bursting external tufted cells (ETCs) of the rodent olfactory bulb glomeruli coordinating the activation of glomerular interneurons and mitral cells via dendrodendritic excitation. However, as bursting has variable significance at axodendritic cortical synapses, it is not clear if ETC bursting imparts a specific functional advantage over the preliminary spike in dendrodendritic synaptic networks. To answer this question, we investigated the influence of single ETC bursts and spikes with the in vitro rat olfactory bulb preparation at different levels of processing, via calcium imaging of presynaptic ETC dendrites, dual electrical recording of ETC -interneuron synaptic pairs, and multicellular calcium imaging of ETC-induced population activity. Our findings supported single ETC bursts, versus single spikes, driving robust presynaptic calcium signaling, which in turn was associated with profound extension of the initial monosynaptic spike-driven dendrodendritic excitatory postsynaptic potential. This extension could be driven by either the spike-dependent or spike-independent components of the burst. At the population level, burst-induced excitation was more widespread and reliable compared with single spikes. This further supports the ETC network, in part due to a functional advantage of bursting at excitatory dendrodendritic synapses, coordinating synchronous activity at behaviorally relevant frequencies related to odor processing in vivo. © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA

Directory of Open Access Journals (Sweden)

Yong Wu

2014-01-01

Full Text Available Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs. Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as nicotinic acetylcholine receptors (nAChRs. Here, we used reversed-phase high performance liquid chromatography (RP-HPLC and electrospray ionization-mass spectrometry (ESI-MS to explore the venom peptide diversity of Conus textile, a species of cone snail native to Hainan, China. One fraction of C. textile crude venom potently blocked α3β2 nAChRs. Subsequent purification, synthesis, and tandem mass spectrometric analysis demonstrated that the most active compound in this fraction was identical to α-CTx TxIA, an antagonist of α3β2 nAChRs. Then three disulfide isoforms of α-CTx TxIA were synthesized and their activities were investigated systematically for the first time. As we observed, disulfide isomerisation was particularly important for α-CTx TxIA potency. Although both globular and ribbon isomers showed similar retention times in RP-HPLC, globular TxIA potently inhibited α3β2 nAChRs with an IC50 of 5.4 nM, while ribbon TxIA had an IC50 of 430 nM. In contrast, beads isomer had little activity towards α3β2 nAChRs. Two-step oxidation synthesis produced the highest yield of α-CTx TxIA native globular isomer, while a one-step production process based on random oxidation folding was not suitable. In summary, this study demonstrated the relationship between conotoxin activity and disulfide connectivity on α-CTx TxIA.

A rapid lateral flow immunoassay for the detection of tyrosine phosphatase-like protein IA-2 autoantibodies in human serum.

Directory of Open Access Journals (Sweden)

Ingrid Kikkas

Full Text Available Type 1 diabetes (T1D results from the destruction of pancreatic insulin-producing beta cells and is strongly associated with the presence of islet autoantibodies. Autoantibodies to tyrosine phosphatase-like protein IA-2 (IA-2As are considered to be highly predictive markers of T1D. We developed a novel lateral flow immunoassay (LFIA based on a bridging format for the rapid detection of IA-2As in human serum samples. In this assay, one site of the IA-2As is bound to HA-tagged-IA-2, which is subsequently captured on the anti-HA-Tag antibody-coated test line on the strip. The other site of the IA-2As is bound to biotinylated IA-2, allowing the complex to be visualized using colloidal gold nanoparticle-conjugated streptavidin. For this study, 35 serum samples from T1D patients and 44 control sera from non-diabetic individuals were analyzed with our novel assay and the results were correlated with two IA-2A ELISAs. Among the 35 serum samples from T1D patients, the IA-2A LFIA, the in-house IA-2A ELISA and the commercial IA-2A ELISA identified as positive 21, 29 and 30 IA-2A-positive sera, respectively. The major advantages of the IA-2A LFIA are its rapidity and simplicity.

UNBURNED MATERIAL IN THE EJECTA OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Folatelli, Gastón; Tanaka, Masaomi; Maeda, Keiichi; Nomoto, Ken'ichi; Phillips, M. M.; Morrell, Nidia; Campillay, Abdo; González, Sergio; Roth, Miguel; Stritzinger, Maximilian; Burns, Christopher R.; Freedman, W. L.; Madore, Barry F; Persson, S. E.; Hamuy, Mario; Mazzali, Paolo; Boldt, Luis; Contreras, Carlos; Salgado, Francisco; Suntzeff, Nicholas B.

2012-01-01

The presence of unburned material in the ejecta of normal Type Ia supernovae (SNe Ia) is investigated using early-time spectroscopy obtained by the Carnegie Supernova Project. The tell-tale signature of pristine material from a C+O white dwarf progenitor star is the presence of carbon, as oxygen is also a product of carbon burning. The most prominent carbon lines in optical spectra of SNe Ia are expected to arise from C II. We find that at least 30% of the objects in the sample show an absorption at ≈6300 Å which is attributed to C II λ6580. An alternative identification of this absorption as Hα is considered to be unlikely. These findings imply a larger incidence of carbon in SNe Ia ejecta than previously noted. We show how observational biases and physical conditions may hide the presence of weak C II lines, and account for the scarcity of previous carbon detections in the literature. This relatively large frequency of carbon detections has crucial implications on our understanding of the explosive process. Furthermore, the identification of the 6300 Å absorptions as carbon would imply that unburned material is present at very low expansion velocities, merely ≈1000 km s –1 above the bulk of Si II. Based on spectral modeling, it is found that the detections are consistent with a mass of carbon of 10 –3 to 10 –2 M ☉ . The presence of this material so deep in the ejecta would imply substantial mixing, which may be related to asymmetries of the flame propagation. Another possible explanation for the carbon absorptions may be the existence of clumps of unburned material along the line of sight. However, the uniformity of the relation between C II and Si II velocities is not consistent with such small-scale asymmetries. The spectroscopic and photometric properties of SNe Ia with and without carbon signatures are compared. A trend toward bluer color and lower luminosity at maximum light is found for objects which show carbon.

UNBURNED MATERIAL IN THE EJECTA OF TYPE Ia SUPERNOVAE

Energy Technology Data Exchange (ETDEWEB)

Folatelli, Gaston; Tanaka, Masaomi; Maeda, Keiichi; Nomoto, Ken' ichi [Institute for the Physics and Mathematics of the Universe (IPMU), University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8583 (Japan); Phillips, M. M.; Morrell, Nidia; Campillay, Abdo; Gonzalez, Sergio; Roth, Miguel [Las Campanas Observatory, Carnegie Observatories, Casilla 601, La Serena (Chile); Stritzinger, Maximilian [The Oskar Klein Centre, Department of Astronomy, Stockholm University, AlbaNova, 10691 Stockholm (Sweden); Burns, Christopher R.; Freedman, W. L.; Madore, Barry F; Persson, S. E. [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara St., Pasadena, CA 91101 (United States); Hamuy, Mario [Departamento de Astronomia, Universidad de Chile, Casilla 36-D, Santiago (Chile); Mazzali, Paolo [Max-Planck Institut fuer Astrophysik, Karl-Schwarzschild-Str. 1, 85748 Garching (Germany); Boldt, Luis [Argelander Institut fuer Astronomie, Universitaet Bonn, Auf dem Huegel 71, D-53111 Bonn (Germany); Contreras, Carlos [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, P.O. Box 218, Victoria 3122 (Australia); Salgado, Francisco [Leiden Observatory, Leiden University, P.O. Box 9513, NL-2300 RA Leiden (Netherlands); Suntzeff, Nicholas B., E-mail: gaston.folatelli@ipmu.jp [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States)

2012-01-20

The presence of unburned material in the ejecta of normal Type Ia supernovae (SNe Ia) is investigated using early-time spectroscopy obtained by the Carnegie Supernova Project. The tell-tale signature of pristine material from a C+O white dwarf progenitor star is the presence of carbon, as oxygen is also a product of carbon burning. The most prominent carbon lines in optical spectra of SNe Ia are expected to arise from C II. We find that at least 30% of the objects in the sample show an absorption at Almost-Equal-To 6300 A which is attributed to C II {lambda}6580. An alternative identification of this absorption as H{alpha} is considered to be unlikely. These findings imply a larger incidence of carbon in SNe Ia ejecta than previously noted. We show how observational biases and physical conditions may hide the presence of weak C II lines, and account for the scarcity of previous carbon detections in the literature. This relatively large frequency of carbon detections has crucial implications on our understanding of the explosive process. Furthermore, the identification of the 6300 A absorptions as carbon would imply that unburned material is present at very low expansion velocities, merely Almost-Equal-To 1000 km s{sup -1} above the bulk of Si II. Based on spectral modeling, it is found that the detections are consistent with a mass of carbon of 10{sup -3} to 10{sup -2} M{sub Sun }. The presence of this material so deep in the ejecta would imply substantial mixing, which may be related to asymmetries of the flame propagation. Another possible explanation for the carbon absorptions may be the existence of clumps of unburned material along the line of sight. However, the uniformity of the relation between C II and Si II velocities is not consistent with such small-scale asymmetries. The spectroscopic and photometric properties of SNe Ia with and without carbon signatures are compared. A trend toward bluer color and lower luminosity at maximum light is found for

Select early type IA endoleaks after endovascular aneurysm repair will resolve without secondary intervention.

Science.gov (United States)

O'Donnell, Thomas F X; Corey, Michael R; Deery, Sarah E; Tsougranis, Gregory; Maruthi, Rohit; Clouse, W Darrin; Cambria, Richard P; Conrad, Mark F

2018-01-01

Although it is traditionally considered ominous, the natural history of early proximal attachment site endoleaks (IA) after endovascular aneurysm repair (EVAR) is not well known. Our aim was to identify risk factors for persistent type IA endoleaks and to determine their effect on long-term outcomes after EVAR. All patients who underwent infrarenal EVAR at a single institution between 1998 and 2015 were identified. Preoperative axial imaging and intraoperative arteriograms were reviewed, and those patients with a type IA endoleak were further studied. Aneurysm features were characterized by two reviewers and were studied for predictors of persistent endoleaks at the conclusion of the case. Patient records and the Social Security Death Index were used to record 1-year and overall survival. We identified 1484 EVARs, 122 (8%) of which were complicated by a type IA endoleak on arteriography after graft deployment, with a median follow-up of 4 years. The majority of patients underwent additional ballooning of the proximal site (52 [43%]) or placement of an aortic cuff (47 [39%]); 30 patients (25%) received a Palmaz stent, and four patients were treated with coils or anchors. At case end, only 43 (35%) of the type IA endoleaks remained; at 1 month, only 16 endoleaks persisted (13%), and only six persisted at 1 year (6%). In multivariable analysis, the only independent predictor of persistence of type IA endoleak at the conclusion of the case was the presence of extensive neck calcifications (odds ratio [OR], 9.9; 95% confidence interval [CI], 1.4-67.9; P = .02). Thirteen patients (11%) underwent reintervention for type IA endoleaks, with a time frame ranging from 3 days postoperatively to 11 years. There were three patients (2.4%) who experienced aneurysm rupture. Postoperative type IA endoleak was associated with lower survival at 1 year (79% vs 91%; relative risk, 2.5; 95% CI, 1.1-5.4; P = .02), but it did not affect long-term survival (log-rank, P = .45

The cosmic transparency measured with Type Ia supernovae: implications for intergalactic dust

Science.gov (United States)

Goobar, Ariel; Dhawan, Suhail; Scolnic, Daniel

2018-04-01

Observations of high-redshift Type Ia supernovae (SNe Ia) are used to study the cosmic transparency at optical wavelengths. Assuming a flat ΛCDM cosmological model based on BAO and CMB results, redshift dependent deviations of SN Ia distances are used to constrain mechanisms that would dim light. The analysis is based on the most recent Pantheon SN compilation, for which there is a 0.03± 0.01 {(stat)} mag discrepancy in the distant supernova distance moduli relative to the ΛCDM model anchored by supernovae at z measurements can be modeled with a cosmic dust density Ω _IGM^dust = 8 \\cdot 10^{-5} (1+z)^{-1}, corresponding to an average attenuation of 2 . 10-5 mag Mpc-1 in V-band. Forthcoming SN Ia studies may provide a definitive measurement of the IGM dust properties, while still providing an unbiased estimate of cosmological parameters by introducing additional parameters in the global fits to the observations.

Optimal properties of analog perceptrons with excitatory weights.

Directory of Open Access Journals (Sweden)

Claudia Clopath

Full Text Available The cerebellum is a brain structure which has been traditionally devoted to supervised learning. According to this theory, plasticity at the Parallel Fiber (PF to Purkinje Cell (PC synapses is guided by the Climbing fibers (CF, which encode an 'error signal'. Purkinje cells have thus been modeled as perceptrons, learning input/output binary associations. At maximal capacity, a perceptron with excitatory weights expresses a large fraction of zero-weight synapses, in agreement with experimental findings. However, numerous experiments indicate that the firing rate of Purkinje cells varies in an analog, not binary, manner. In this paper, we study the perceptron with analog inputs and outputs. We show that the optimal input has a sparse binary distribution, in good agreement with the burst firing of the Granule cells. In addition, we show that the weight distribution consists of a large fraction of silent synapses, as in previously studied binary perceptron models, and as seen experimentally.

Inferring Trial-to-Trial Excitatory and Inhibitory Synaptic Inputs from Membrane Potential using Gaussian Mixture Kalman Filtering

Directory of Open Access Journals (Sweden)

Milad eLankarany

2013-09-01

Full Text Available Time-varying excitatory and inhibitory synaptic inputs govern activity of neurons and process information in the brain. The importance of trial-to-trial fluctuations of synaptic inputs has recently been investigated in neuroscience. Such fluctuations are ignored in the most conventional techniques because they are removed when trials are averaged during linear regression techniques. Here, we propose a novel recursive algorithm based on Gaussian mixture Kalman filtering for estimating time-varying excitatory and inhibitory synaptic inputs from single trials of noisy membrane potential in current clamp recordings. The Kalman filtering is followed by an expectation maximization algorithm to infer the statistical parameters (time-varying mean and variance of the synaptic inputs in a non-parametric manner. As our proposed algorithm is repeated recursively, the inferred parameters of the mixtures are used to initiate the next iteration. Unlike other recent algorithms, our algorithm does not assume an a priori distribution from which the synaptic inputs are generated. Instead, the algorithm recursively estimates such a distribution by fitting a Gaussian mixture model. The performance of the proposed algorithms is compared to a previously proposed PF-based algorithm (Paninski et al., 2012 with several illustrative examples, assuming that the distribution of synaptic input is unknown. If noise is small, the performance of our algorithms is similar to that of the previous one. However, if noise is large, they can significantly outperform the previous proposal. These promising results suggest that our algorithm is a robust and efficient technique for estimating time varying excitatory and inhibitory synaptic conductances from single trials of membrane potential recordings.

IAS/IFRS and financial reporting quality: Lessons from the European experience

Directory of Open Access Journals (Sweden)

Vera Palea

2013-12-01

Full Text Available This paper discusses the effects of the adoption of IAS/IFRS in Europe on the quality of financial reporting. In doing so, it adopts the perspective of stock market investors and focuses on value-relevance research. The adoption of IAS/IFRS in Europe is an example of accounting standardization among countries with different institutional frameworks and enforcement rules. This allows investigating whether, and to what extent, accounting regulation per se can affect the quality of financial reporting and leads to convergence in financial reporting. This is a key issue for standard setting purposes as IAS/IFRS have been adopted in very diverse countries all over the world, and many others are likely to adopt them in the near future.

A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2beta).

NARCIS (Netherlands)

Drake, P.G.; Peters, G.H.; Andersen, H.S.; Hendriks, W.J.A.J.; Moller, N.P.

2003-01-01

Islet-cell antigen 512 (IA-2) and phogrin (IA-2beta) are atypical members of the receptor protein tyrosine phosphatase (PTP) family that are characterized by a lack of activity against conventional PTP substrates. The physiological role(s) of these proteins remain poorly defined, although recent

Testing cosmic transparency with the latest baryon acoustic oscillations and type Ia supernovae data

International Nuclear Information System (INIS)

Chen Jun; Yu Hong-Wei; Li Zheng-Xiang; Wu Pu-Xun

2013-01-01

Observations show that Type Ia supernovae (SNe Ia) are dimmer than expected from a matter dominated Universe. It has been suggested that this observed phenomenon can also be explained using light absorption instead of dark energy. However, there is a serious degeneracy between the cosmic absorption parameter and the present matter density parameter Ω m when one tries to place constraints on the cosmic opacity using SNe Ia data. We combine the latest baryon acoustic oscillation (BAO) and Union2 SNe Ia data in order to break this degeneracy. Assuming a flat ΛCDM model, we find that, although an opaque Universe is favored by SNe Ia+BAO since the best fit value of the cosmic absorption parameter is larger than zero, Ω m = 1 is ruled out at the 99.7% confidence level. Thus, cosmic opacity is not sufficient to account for the present observations and dark energy or modified gravity is still required.

THE CARNEGIE SUPERNOVA PROJECT: FIRST PHOTOMETRY DATA RELEASE OF LOW-REDSHIFT TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Contreras, Carlos; Phillips, M. M.; Folatelli, Gaston; Stritzinger, Maximilian; Boldt, Luis; Gonzalez, Sergio; Krzeminski, Wojtek; Morrell, Nidia; Roth, Miguel; Salgado, Francisco; Hamuy, Mario; Maureira, MarIa Jose; Suntzeff, Nicholas B.; Persson, S. E.; Burns, Christopher R.; Freedman, W. L.; Madore, Barry F.; Murphy, David; Wyatt, Pamela; Li Weidong

2010-01-01

The Carnegie Supernova Project (CSP) is a five-year survey being carried out at the Las Campanas Observatory to obtain high-quality light curves of ∼100 low-redshift Type Ia supernovae (SNe Ia) in a well-defined photometric system. Here we present the first release of photometric data that contains the optical light curves of 35 SNe Ia, and near-infrared light curves for a subset of 25 events. The data comprise 5559 optical (ugriBV) and 1043 near-infrared (Y JHK s ) data points in the natural system of the Swope telescope. Twenty-eight SNe have pre-maximum data, and for 15 of these, the observations begin at least 5 days before B maximum. This is one of the most accurate data sets of low-redshift SNe Ia published to date. When completed, the CSP data set will constitute a fundamental reference for precise determinations of cosmological parameters, and serve as a rich resource for comparison with models of SNe Ia.

Learning from the scatter in type ia supernovae

Energy Technology Data Exchange (ETDEWEB)

Dodelson, Scott; /Fermilab /Chicago U., Astron. Astrophys. Ctr.; Vallinotto, Alberto; /Fermilab /Chicago U.

2005-11-01

Type Ia Supernovae are standard candles so their mean apparent magnitude has been exploited to learn about the redshift-distance relationship. Besides intrinsic scatter in this standard candle, additional scatter is caused by gravitational magnification by large scale structure. Here they probe the dependence of this dispersion on cosmological parameters and show that information about the amplitude of clustering, {sigma}{sub s}, is contained in the scatter. In principle, it will be possible to constrain {sigma}{sub s} to within 5% with observations of 2000 Type Ia Supernovae. They identify three sources of systematic error--evolution of intrinsic scatter, baryon contributions to lensing, and non-Gaussianity of lensing--which will make this measurement difficult.

Neuroligin-1 loss is associated with reduced tenacity of excitatory synapses.

Directory of Open Access Journals (Sweden)

Adel Zeidan

Full Text Available Neuroligins (Nlgns are postsynaptic, integral membrane cell adhesion molecules that play important roles in the formation, validation, and maturation of synapses in the mammalian central nervous system. Given their prominent roles in the life cycle of synapses, it might be expected that the loss of neuroligin family members would affect the stability of synaptic organization, and ultimately, affect the tenacity and persistence of individual synaptic junctions. Here we examined whether and to what extent the loss of Nlgn-1 affects the dynamics of several key synaptic molecules and the constancy of their contents at individual synapses over time. Fluorescently tagged versions of the postsynaptic scaffold molecule PSD-95, the AMPA-type glutamate receptor subunit GluA2 and the presynaptic vesicle molecule SV2A were expressed in primary cortical cultures from Nlgn-1 KO mice and wild-type (WT littermates, and live imaging was used to follow the constancy of their contents at individual synapses over periods of 8-12 hours. We found that the loss of Nlgn-1 was associated with larger fluctuations in the synaptic contents of these molecules and a poorer preservation of their contents at individual synapses. Furthermore, rates of synaptic turnover were somewhat greater in neurons from Nlgn-1 knockout mice. Finally, the increased GluA2 redistribution rates observed in neurons from Nlgn-1 knockout mice were negated by suppressing spontaneous network activity. These findings suggest that the loss of Nlgn-1 is associated with some use-dependent destabilization of excitatory synapse organization, and indicate that in the absence of Nlgn-1, the tenacity of excitatory synapses might be somewhat impaired.

Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex

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Gabriele Radnikow

2018-01-01

Full Text Available From an anatomical point of view the neocortex is subdivided into up to six layers depending on the cortical area. This subdivision has been described already by Meynert and Brodmann in the late 19/early 20. century and is mainly based on cytoarchitectonic features such as the size and location of the pyramidal cell bodies. Hence, cortical lamination is originally an anatomical concept based on the distribution of excitatory neuron. However, it has become apparent in recent years that apart from the layer-specific differences in morphological features, many functional properties of neurons are also dependent on cortical layer or cell type. Such functional differences include changes in neuronal excitability and synaptic activity by neuromodulatory transmitters. Many of these neuromodulators are released from axonal afferents from subcortical brain regions while others are released intrinsically. In this review we aim to describe layer- and cell-type specific differences in the effects of neuromodulator receptors in excitatory neurons in layers 2–6 of different cortical areas. We will focus on the neuromodulator systems using adenosine, acetylcholine, dopamine, and orexin/hypocretin as examples because these neuromodulator systems show important differences in receptor type and distribution, mode of release and functional mechanisms and effects. We try to summarize how layer- and cell type-specific neuromodulation may affect synaptic signaling in cortical microcircuits.

Muudetud IFRS 3 ja IAS 27 / Monika Peetson

Index Scriptorium Estoniae

Peetson, Monika, 1976-

2008-01-01

Rahvusvahelise Raamatupidamisstandardite Nõukogu poolt välja antud muudetud standarditest IFRS 3 "Äriühendused" ja IAS 27 "Konsolideeritud ja konsolideerimata finantsaruanded" ning nendega kaasnevatest muudatustest

Recent development and gene therapy for glycogen storage disease type Ia.

Science.gov (United States)

Chou, Janice Y; Kim, Goo-Young; Cho, Jun-Ho

2017-09-01

Glycogen storage disease type Ia (GSD-Ia) is an autosomal recessive metabolic disorder caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) that is expressed primarily in the liver, kidney, and intestine. G6Pase-α catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of gluconeogenesis and glycogenolysis, and is a key enzyme for endogenous glucose production. The active site of G6Pase-α is inside the endoplasmic reticulum (ER) lumen. For catalysis, the substrate G6P must be translocated from the cytoplasm into the ER lumen by a G6P transporter (G6PT). The functional coupling of G6Pase-α and G6PT maintains interprandial glucose homeostasis. Dietary therapies for GSD-Ia are available, but cannot prevent the long-term complication of hepatocellular adenoma that may undergo malignant transformation to hepatocellular carcinoma. Animal models of GSD-Ia are now available and are being exploited to both delineate the disease more precisely and develop new treatment approaches, including gene therapy.

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

DEFF Research Database (Denmark)

Sette, A; Buus, S; Colon, S

1987-01-01

A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact...... both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor....

RADIOACTIVELY POWERED RISING LIGHT CURVES OF TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Piro, Anthony L.

2012-01-01

The rising luminosity of the recent, nearby supernova 2011fe shows a quadratic dependence with time during the first ≈0.5-4 days. In addition, studies of the composite light curves formed from stacking together many Type Ia supernovae (SNe Ia) have found similar power-law indices for the rise, but may also show some dispersion that may indicate diversity. I explore what range of power-law rises are possible due to the presence of radioactive material near the surface of the exploding white dwarf (WD). I summarize what constraints such a model places on the structure of the progenitor and the distribution and velocity of ejecta. My main conclusion is that for the inferred explosion time for SN 2011fe, its rise requires an increasing mass fraction X 56 ≈ (4-6) × 10 –2 of 56 Ni distributed between a depth of ≈10 –2 and 0.3 M ☉ below the WD's surface. Radioactive elements this shallow are not found in simulations of a single C/O detonation. Scenarios that may produce this material include helium-shell burning during a double-detonation ignition, a gravitationally confined detonation, and a subset of deflagration to detonation transition models. In general, the power-law rise can differ from quadratic depending on the details of the velocity, density, and radioactive deposition gradients in a given event. Therefore, comparisons of this work with observed bolometric rises of SNe Ia would place strong constraints on the properties of the shallow outer layers, providing important clues for identifying the elusive progenitors of SNe Ia.

TYPE Ia SUPERNOVA LIGHT-CURVE INFERENCE: HIERARCHICAL BAYESIAN ANALYSIS IN THE NEAR-INFRARED

International Nuclear Information System (INIS)

Mandel, Kaisey S.; Friedman, Andrew S.; Kirshner, Robert P.; Wood-Vasey, W. Michael

2009-01-01

We present a comprehensive statistical analysis of the properties of Type Ia supernova (SN Ia) light curves in the near-infrared using recent data from Peters Automated InfraRed Imaging TELescope and the literature. We construct a hierarchical Bayesian framework, incorporating several uncertainties including photometric error, peculiar velocities, dust extinction, and intrinsic variations, for principled and coherent statistical inference. SN Ia light-curve inferences are drawn from the global posterior probability of parameters describing both individual supernovae and the population conditioned on the entire SN Ia NIR data set. The logical structure of the hierarchical model is represented by a directed acyclic graph. Fully Bayesian analysis of the model and data is enabled by an efficient Markov Chain Monte Carlo algorithm exploiting the conditional probabilistic structure using Gibbs sampling. We apply this framework to the JHK s SN Ia light-curve data. A new light-curve model captures the observed J-band light-curve shape variations. The marginal intrinsic variances in peak absolute magnitudes are σ(M J ) = 0.17 ± 0.03, σ(M H ) = 0.11 ± 0.03, and σ(M Ks ) = 0.19 ± 0.04. We describe the first quantitative evidence for correlations between the NIR absolute magnitudes and J-band light-curve shapes, and demonstrate their utility for distance estimation. The average residual in the Hubble diagram for the training set SNe at cz > 2000kms -1 is 0.10 mag. The new application of bootstrap cross-validation to SN Ia light-curve inference tests the sensitivity of the statistical model fit to the finite sample and estimates the prediction error at 0.15 mag. These results demonstrate that SN Ia NIR light curves are as effective as corrected optical light curves, and, because they are less vulnerable to dust absorption, they have great potential as precise and accurate cosmological distance indicators.

Advantages and limitation of intra-arterial digital subtraction angiography (i.a. DSA)

International Nuclear Information System (INIS)

Beduhn, D.

1986-01-01

Among 3000 digital subtraction angiographies which have been performed in our institute, 850 patients have been examined intraarterially. The advantage of i.a. DSA is due to the excellent demonstration of vessels in survey angiograms by small amounts of contrast medium (10-20 ml in the aorta), without risk of selective catheterisation into the neck vessels, the saving of expensive film series, the short duration of vessel examinations and the small complication rate. i.a. DSA can be carried out on outpatients also, using the 4/5 F-catheter, which saves hospital charges. Impressive examples show the advantages of i.a. DSA. (orig.) [de

Supernovae Ia in 2017: a long time delay from merger/accretion to explosion

Science.gov (United States)

Soker, Noam

2018-04-01

I use recent observational and theoretical studies of type Ia supernovae (SNe Ia) to further constrain the viable SN Ia scenarios and to argue that there must be a substantial time delay between the end of the merger of the white dwarf (WD) with a companion or the end of mass accretion on to the WD and its terminal explosion. This merger/accretion to explosion delay (MED) is required to allow the binary system to lead to a more or less spherical explosion and to prevent a pre-explosion ionizing radiation. Considering these recent results and the required MED, I conclude that the core degenerate scenario is somewhat more favorable over the other scenarios, followed by the double degenerate scenario. Although the single degenerate scenario is viable as well, it is less likely to account for common (normal) SN Ia. As all scenarios require substantial MED, the MED has turned from a disadvantage of the core degenerate scenario to a challenge that theory should overcome. I hope that the requirement for a MED will stimulate the discussion of the different SN Ia scenarios and the comparison of the scenarios to each other.

Value of diffusion-weighted imaging in predicting parametrial invasion in stage IA2-IIA cervical cancer

International Nuclear Information System (INIS)

Park, Jung Jae; Kim, Chan Kyo; Park, Sung Yoon; Park, Byung Kwan; Kim, Bohyun

2014-01-01

To investigate the value of diffusion-weighted imaging (DWI) in evaluating parametrial invasion (PMI) in stage IA2-IIA cervical cancer. A total of 117 patients with stage IA2-IIA cervical cancer who underwent preoperative MRI and radical hysterectomy were included in this study. Preoperative clinical variables and MRI variables were analysed and compared between the groups with and without pathologically proven PMI. All variables except age were significantly different between patients with and without pathologic PMI (P < 0.05). All variables except squamous cell carcinoma (SCC) antigen were also significantly correlated with pathologic PMI on univariate analysis (P < 0.05). Multivariate analysis indicated that PMI on MRI (P < 0.001) and tumour apparent diffusion coefficient (ADC) (P = 0.029) were independent predictors of pathologic PMI. Area under the curve of PMI on MRI increased significantly from 0.793 to 0.872 when combined with tumour ADC (P = 0.002). When PMI on MRI was further stratified by tumour ADC, the false negative rate was 2.0 % (1/49). In stage IA2-IIA cervical cancer, tumour ADC and PMI on MRI seem to be independent predictors of pathologic PMI. Combining the two predictors improved the diagnostic performance of identifying patients at low risk of pathologic PMI. (orig.)

As identidades ficcionais de Raul Pompéia

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Franco Baptista Sandanello

2014-12-01

Full Text Available A fortuna crítica da obra de Raul Pompéia – especialmente, de seu romance O Ateneu – foi marcada por uma forte aproximação entre a vida do escritor e sua ficção. No entanto, pouco se falou a respeito de um aspecto muito curioso desta relação complexa entre vida e arte: o papel subsequente de Pompéia na literatura brasileira não como escritor, mas como personagem. Curiosamente, o romancista integra a trama de obras ficcionais como, por exemplo, Tentação, de Adolfo Caminha, O canudo, de Afonso Schmidt, e Investigação sobre Ariel, de Sílvio Fiorani. Nesse sentido, a partir de uma comparação entre estas obras, será discutida a possível figuração ficcional de Pompéia, assim como a posição particular de sua subjetividade dentro da mecânica narrativa de cada texto. Do primeiro ao último, há, por assim dizer, um progressivo distanciamento do universo ficcional por ele   criado (como o do citado O Ateneu e uma ênfase cada vez    maior em suas crises e inquietações pessoais. The critical reception of Raul Pompéia’s work – especially that of O Ateneu – has strongly identified over the years his biography to his fiction. However, very little was said on a    very peculiar aspect of this complex link between life and art: the subsequent role of Pompéia in Brazilian literature not as a    writer, but as a fictional character. Curiously, the writer integrates the plot of fictional works such as Tentação, by Adolfo Caminha, O canudo, by Afonso Schmidt, and Investigação sobre Ariel, by Sílvio Fiorani. In this regard, from an initial comparison of these texts, this article discusses the fictional figure of Pompéia, as well as the particular standing of his subjectivity in each narrative. So to speak, in these texts there is a gradual detachment of the fictional universe of his own    works (as that of O Ateneu and an increasing emphasis on his personal dramas and crisis.

A TYPE Ia SUPERNOVA AT REDSHIFT 1.55 IN HUBBLE SPACE TELESCOPE INFRARED OBSERVATIONS FROM CANDELS

International Nuclear Information System (INIS)

Rodney, Steven A.; Riess, Adam G.; Jones, David O.; Dahlen, Tomas; Ferguson, Henry C.; Casertano, Stefano; Grogin, Norman A.; Strolger, Louis-Gregory; Hjorth, Jens; Frederiksen, Teddy F.; Weiner, Benjamin J.; Mobasher, Bahram; Challis, Peter; Kirshner, Robert P.; Faber, S. M.; Filippenko, Alexei V.; Garnavich, Peter; Hayden, Brian; Graur, Or; Jha, Saurabh W.

2012-01-01

We report the discovery of a Type Ia supernova (SN Ia) at redshift z = 1.55 with the infrared detector of the Wide Field Camera 3 (WFC3-IR) on the Hubble Space Telescope (HST). This object was discovered in CANDELS imaging data of the Hubble Ultra Deep Field and followed as part of the CANDELS+CLASH Supernova project, comprising the SN search components from those two HST multi-cycle treasury programs. This is the highest redshift SN Ia with direct spectroscopic evidence for classification. It is also the first SN Ia at z > 1 found and followed in the infrared, providing a full light curve in rest-frame optical bands. The classification and redshift are securely defined from a combination of multi-band and multi-epoch photometry of the SN, ground-based spectroscopy of the host galaxy, and WFC3-IR grism spectroscopy of both the SN and host. This object is the first of a projected sample at z > 1.5 that will be discovered by the CANDELS and CLASH programs. The full CANDELS+CLASH SN Ia sample will enable unique tests for evolutionary effects that could arise due to differences in SN Ia progenitor systems as a function of redshift. This high-z sample will also allow measurement of the SN Ia rate out to z ≈ 2, providing a complementary constraint on SN Ia progenitor models.

TYPE Ia SUPERNOVA PROGENITORS AND CHEMICAL ENRICHMENT IN HYDRODYNAMICAL SIMULATIONS. I. THE SINGLE-DEGENERATE SCENARIO

Energy Technology Data Exchange (ETDEWEB)

Jiménez, Noelia [School of Physics and Astronomy, University of St. Andrews, North Haugh, St. Andrews, KY16 9SS, Scotland (United Kingdom); Tissera, Patricia B. [Instituto de Astronomía y Física del Espacio (IAFE, CONICET-UBA), CC. 67 Suc. 28, C1428ZAA, Ciudad de Buenos Aires (Argentina); Matteucci, Francesca, E-mail: nj22@st-andrews.ac.uk [Dipartimento di Fisica, Universita’ di Trieste, Via G. B. Tiepolo, 11, I-34100, Trieste (Italy)

2015-09-10

The nature of the Type Ia supernova (SN Ia) progenitors remains uncertain. This is a major issue for galaxy evolution models since both chemical and energetic feedback plays a major role in the gas dynamics, star formation, and therefore the overall stellar evolution. The progenitor models for the SNe Ia available in the literature propose different distributions for regulating the explosion times of these events. These functions are known as the delay time distributions (DTDs). This work is the first one in a series of papers aiming at studying five different DTDs for SNe Ia. Here we implement and analyze the single-degenerate (SD) scenario in galaxies dominated by a rapid quenching of the star formation, displaying the majority of the stars concentrated in the bulge component. We find a good fit to both the present observed SN Ia rates in spheroidal-dominated galaxies and the [O/Fe] ratios shown by the bulge of the Milky Way. Additionally, the SD scenario is found to reproduce a correlation between the specific SN Ia rate and the specific star formation rate (sSFR), which closely resembles the observational trend, at variance with previous works. Our results suggest that SN Ia observations in galaxies with very low and very high sSFRs can help to impose more stringent constraints on the DTDs and therefore on SN Ia progenitors.

On type Ia supernovae and the formation of single low-mass white dwarfs

OpenAIRE

Justham, Stephen; Wolf, Christian; Podsiadlowski, Philipp; Han, Zhanwen

2008-01-01

There is still considerable debate over the progenitors of type Ia supernovae (SNe Ia). Likewise, it is not agreed how single white dwarfs with masses less than ~0.5 Msun can be formed in the field, even though they are known to exist. We consider whether single low-mass white dwarfs (LMWDs) could have been formed in binary systems where their companions have exploded as a SN Ia. In this model, the observed single LMWDs are the remnants of giant-branch donor stars whose envelopes have been st...

Does adjuvant therapy improve overall survival for stage IA/B pancreatic adenocarcinoma?

Science.gov (United States)

Ostapoff, Katherine T; Gabriel, Emmanuel; Attwood, Kristopher; Kuvshinoff, Boris W; Nurkin, Steven J; Hochwald, Steven N

2017-07-01

Current guidelines recommend adjuvant chemotherapy for resected pancreatic adenocarcinoma (PDAC). However, no studies have addressed its survival benefit for stage I patients as they comprise IA or IB PDAC were identified. Median OS was 60.3 months (mo) for stage IA and 36.9 mo for IB. 45.5% received adjuvant chemotherapy; 19.9% received adjuvant chemoradiation. There was OS benefit for both stage IA/IB patients with adjuvant chemotherapy (HR = 0.73 and 0.76 for IA and IB, respectively, p = 0.002 and IA disease (n = 1,477, 37.8%), age ≥70 (p < 0.001), higher grade (p < 0.001), ≤10 lymph nodes examined (p = 0.008), positive margins (p < 0.001), and receipt of adjuvant chemoradiation (p = 0.002) were associated with worse OS. For stage IB patients (n = 2,432, 62.2%), similar associations were observed with the exception of adjuvant chemoradiation whereby there was no significant association (p = 0.35). Adjuvant chemotherapy was associated with an OS benefit for patients with stage I PDAC; adjuvant chemoradiation was either of no benefit or associated with worse OS. Copyright © 2017 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials

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Vera Moliadze

2014-01-01

Full Text Available The common aim of transcranial stimulation methods is the induction or alterations of cortical excitability in a controlled way. Significant effects of each individual stimulation method have been published; however, conclusive direct comparisons of many of these methods are rare. The aim of the present study was to compare the efficacy of three widely applied stimulation methods inducing excitability enhancement in the motor cortex: 1 mA anodal transcranial direct current stimulation (atDCS, intermittent theta burst stimulation (iTBS, and 1 mA transcranial random noise stimulation (tRNS within one subject group. The effect of each stimulation condition was quantified by evaluating motor-evoked-potential amplitudes (MEPs in a fixed time sequence after stimulation. The analyses confirmed a significant enhancement of the M1 excitability caused by all three types of active stimulations compared to sham stimulation. There was no significant difference between the types of active stimulations, although the time course of the excitatory effects slightly differed. Among the stimulation methods, tRNS resulted in the strongest and atDCS significantly longest MEP increase compared to sham. Different time courses of the applied stimulation methods suggest different underlying mechanisms of action. Better understanding may be useful for better targeting of different transcranial stimulation techniques.

Homeostatic regulation of excitatory synapses on striatal medium spiny neurons expressing the D2 dopamine receptor.

Science.gov (United States)

Thibault, Dominic; Giguère, Nicolas; Loustalot, Fabien; Bourque, Marie-Josée; Ducrot, Charles; El Mestikawy, Salah; Trudeau, Louis-Éric

2016-05-01

Striatal medium spiny neurons (MSNs) are contacted by glutamatergic axon terminals originating from cortex, thalamus and other regions. The striatum is also innervated by dopaminergic (DAergic) terminals, some of which release glutamate as a co-transmitter. Despite evidence for functional DA release at birth in the striatum, the role of DA in the establishment of striatal circuitry is unclear. In light of recent work suggesting activity-dependent homeostatic regulation of glutamatergic terminals on MSNs expressing the D2 DA receptor (D2-MSNs), we used primary co-cultures to test the hypothesis that stimulation of DA and glutamate receptors regulates the homeostasis of glutamatergic synapses on MSNs. Co-culture of D2-MSNs with mesencephalic DA neurons or with cortical neurons produced an increase in spines and functional glutamate synapses expressing VGLUT2 or VGLUT1, respectively. The density of VGLUT2-positive terminals was reduced by the conditional knockout of this gene from DA neurons. In the presence of both mesencephalic and cortical neurons, the density of synapses reached the same total, compatible with the possibility of a homeostatic mechanism capping excitatory synaptic density. Blockade of D2 receptors increased the density of cortical and mesencephalic glutamatergic terminals, without changing MSN spine density or mEPSC frequency. Combined blockade of AMPA and NMDA glutamate receptors increased the density of cortical terminals and decreased that of mesencephalic VGLUT2-positive terminals, with no net change in total excitatory terminal density or in mEPSC frequency. These results suggest that DA and glutamate signaling regulate excitatory inputs to striatal D2-MSNs at both the pre- and postsynaptic level, under the influence of a homeostatic mechanism controlling functional output of the circuit.

A spectroscopic look at the gravitationally lensed Type Ia supernova 2016geu at z = 0.409

DEFF Research Database (Denmark)

Cano, Z.; Selsing, J.; Hjorth, J.

2018-01-01

The spectacular success of Type Ia supernovae (SNe Ia) in SN-cosmology is based on the assumption that their photometric and spectroscopic properties are invariant with redshift. However, this fundamental assumption needs to be tested with observations of high-z SNe Ia. To date, the majority of SNe...... Ia observed at moderate to large redshifts (0.4 le z le 1.0) are faint, and the resultant analyses are based on observations with modest signal-to-noise ratios that impart a degree of ambiguity in their determined properties. In rare cases, however, the Universe offers a helping hand: To date a few...... SNe Ia have been observed that have had their luminosities magnified by intervening galaxies and galaxy clusters acting as gravitational lenses. In this paper, we present long-slit spectroscopy of the lensed SN Ia 2016geu, which occurred at a redshift of z = 0.409, and was magnified by a factor of ap...

Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.

Science.gov (United States)

Puranam, Ram S; He, Xiao Ping; Yao, Lijun; Le, Tri; Jang, Wonjo; Rehder, Catherine W; Lewis, Darrell V; McNamara, James O

2015-06-10

We identified a family in which a translocation between chromosomes X and 14 was associated with cognitive impairment and a complex genetic disorder termed "Genetic Epilepsy and Febrile Seizures Plus" (GEFS(+)). We demonstrate that the breakpoint on the X chromosome disrupted a gene that encodes an auxiliary protein of voltage-gated Na(+) channels, fibroblast growth factor 13 (Fgf13). Female mice in which one Fgf13 allele was deleted exhibited hyperthermia-induced seizures and epilepsy. Anatomic studies revealed expression of Fgf13 mRNA in both excitatory and inhibitory neurons of hippocampus. Electrophysiological recordings revealed decreased inhibitory and increased excitatory synaptic inputs in hippocampal neurons of Fgf13 mutants. We speculate that reduced expression of Fgf13 impairs excitability of inhibitory interneurons, resulting in enhanced excitability within local circuits of hippocampus and the clinical phenotype of epilepsy. These findings reveal a novel cause of this syndrome and underscore the powerful role of FGF13 in control of neuronal excitability. Copyright © 2015 the authors 0270-6474/15/358866-16$15.00/0.

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function

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Lucas Matt

2018-02-01

Full Text Available Altering AMPA receptor (AMPAR content at synapses is a key mechanism underlying the regulation of synaptic strength during learning and memory. Previous work demonstrated that SynDIG1 (synapse differentiation-induced gene 1 encodes a transmembrane AMPAR-associated protein that regulates excitatory synapse strength and number. Here we show that the related protein SynDIG4 (also known as Prrt1 modifies AMPAR gating properties in a subunit-dependent manner. Young SynDIG4 knockout (KO mice have weaker excitatory synapses, as evaluated by immunocytochemistry and electrophysiology. Adult SynDIG4 KO mice show complete loss of tetanus-induced long-term potentiation (LTP, while mEPSC amplitude is reduced by only 25%. Furthermore, SynDIG4 KO mice exhibit deficits in two independent cognitive assays. Given that SynDIG4 colocalizes with the AMPAR subunit GluA1 at non-synaptic sites, we propose that SynDIG4 maintains a pool of extrasynaptic AMPARs necessary for synapse development and function underlying higher-order cognitive plasticity.

351.pdf | mar2007 | jbiosci | www.ias.ac.in | | http: | Indian Academy ...

Indian Academy of Sciences (India)

Home; http: www.ias.ac.in; jbiosci; mar2007; 351.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Summer Research Fellowship Programme 2018. Posted on 16 December 2017.

Stochastic gravitational wave background from the single-degenerate channel of type Ia supernovae

International Nuclear Information System (INIS)

Falta, David; Fisher, Robert

2011-01-01

We demonstrate that the integrated gravitational wave signal of type Ia supernovae (SNe Ia) in the single-degenerate channel out to cosmological distances gives rise to a continuous background to spaceborne gravitational wave detectors, including the Big Bang Observer and Deci-Hertz Interferometer Gravitational wave Observatory planned missions. This gravitational wave background from SNe Ia acts as a noise background in the frequency range 0.1-10 Hz, which heretofore was thought to be relatively free from astrophysical sources apart from neutron-star and white-dwarf binaries, and therefore a key window in which to study primordial gravitational waves generated by inflation. While inflationary energy scales of > or approx. 10 16 GeV yield inflationary gravitational wave backgrounds in excess of our range of predicted backgrounds, for lower energy scales of ∼10 15 GeV, the inflationary gravitational wave background becomes comparable to the noise background from SNe Ia.

Swift UVOT Grism Observations of Nearby Type Ia Supernovae - I. Observations and Data Reduction

Science.gov (United States)

Pan, Y.-C.; Foley, R. J.; Filippenko, A. V.; Kuin, N. P. M.

2018-05-01

Ultraviolet (UV) observations of Type Ia supernovae (SNe Ia) are useful tools for understanding progenitor systems and explosion physics. In particular, UV spectra of SNe Ia, which probe the outermost layers, are strongly affected by the progenitor metallicity. In this work, we present 120 Neil Gehrels Swift Observatory UV spectra of 39 nearby SNe Ia. This sample is the largest UV (λ Ia to date, doubling the number of UV spectra and tripling the number of SNe with UV spectra. The sample spans nearly the full range of SN Ia light-curve shapes (Δm15(B) ≈ 0.6-1.8 mag). The fast turnaround of Swift allows us to obtain UV spectra at very early times, with 13 out of 39 SNe having their first spectra observed ≳ 1 week before peak brightness and the earliest epoch being 16.5 days before peak brightness. The slitless design of the Swift UV grism complicates the data reduction, which requires separating SN light from underlying host-galaxy light and occasional overlapping stellar light. We present a new data-reduction procedure to mitigate these issues, producing spectra that are significantly improved over those of standard methods. For a subset of the spectra we have nearly simultaneous Hubble Space Telescope UV spectra; the Swift spectra are consistent with these comparison data.

Operational calibration and validation of landsat data continuity mission (LDCM) sensors using the image assessment system (IAS)

Science.gov (United States)

Micijevic, Esad; Morfitt, Ron

2010-01-01

Systematic characterization and calibration of the Landsat sensors and the assessment of image data quality are performed using the Image Assessment System (IAS). The IAS was first introduced as an element of the Landsat 7 (L7) Enhanced Thematic Mapper Plus (ETM+) ground segment and recently extended to Landsat 4 (L4) and 5 (L5) Thematic Mappers (TM) and Multispectral Sensors (MSS) on-board the Landsat 1-5 satellites. In preparation for the Landsat Data Continuity Mission (LDCM), the IAS was developed for the Earth Observer 1 (EO-1) Advanced Land Imager (ALI) with a capability to assess pushbroom sensors. This paper describes the LDCM version of the IAS and how it relates to unique calibration and validation attributes of its on-board imaging sensors. The LDCM IAS system will have to handle a significantly larger number of detectors and the associated database than the previous IAS versions. An additional challenge is that the LDCM IAS must handle data from two sensors, as the LDCM products will combine the Operational Land Imager (OLI) and Thermal Infrared Sensor (TIRS) spectral bands.

Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors

Directory of Open Access Journals (Sweden)

Orth Angela

2009-04-01

Full Text Available Abstract Background N-methyl-D-aspartate receptors (NMDARs are the most complex of ionotropic glutamate receptors (iGluRs. Subunits of this subfamily assemble into heteromers, which – depending on the subunit combination – may display very different pharmacological and electrophysiological properties. The least studied members of the NMDAR family, the NR3 subunits, have been reported to assemble with NR1 to form excitatory glycine receptors in heterologous expression systems. The heterogeneity of NMDARs in vivo is in part conferred to the receptors by splicing of the NR1 subunit, especially with regard to proton sensitivity. Results Here, we have investigated whether the NR3B subunit is capable of assembly with each of the eight functional NR1 splice variants, and whether the resulting receptors share the unique functional properties described for NR1-1a/NR3. We provide evidence that functional excitatory glycine receptors formed regardless of the NR1 isoform, and their pharmacological profile matched the one reported for NR1-1a/NR3: glycine alone fully activated the receptors, which were insensitive to glutamate and block by Mg2+. Surprisingly, amplitudes of agonist-induced currents showed little dependency on the C-terminally spliced NR1 variants in NR1/NR3B diheteromers. Even more strikingly, NR3B conferred proton sensitivity also to receptors containing NR1b variants – possibly via disturbing the "proton shield" of NR1b splice variants. Conclusion While functional assembly could be demonstrated for all combinations, not all of the specific interactions seen for NR1 isoforms with coexpressed NR2 subunits could be corroborated for NR1 assembly with NR3. Rather, NR3 abates trafficking effects mediated by the NR1 C terminus as well as the N-terminally mediated proton insensitivity. Thus, this study establishes that NR3B overrides important NR1 splice variant-specific receptor properties in NR1/NR3B excitatory glycine receptors.

Identification of EhTIF-IA: The putative E. histolytica orthologue of the ...

Indian Academy of Sciences (India)

2016-02-04

Feb 4, 2016 ... We have identified the E. histolytica equivalent of TIF-1A (EhTIF-IA) by homology search within ..... a putative EhTIF-IA with e-value (3e−25). Comparison of .... some biogenesis is correlated with altered rates of rDNA transcription ..... ylation by CK2 facilitates rDNA transcription by promoting dissociation of ...

IMPROVED DARK ENERGY CONSTRAINTS FROM ∼100 NEW CfA SUPERNOVA TYPE Ia LIGHT CURVES

International Nuclear Information System (INIS)

Hicken, Malcolm; Challis, Peter; Kirshner, Robert P.; Wood-Vasey, W. Michael; Blondin, Stephane; Jha, Saurabh; Kelly, Patrick L.; Rest, Armin

2009-01-01

We combine the CfA3 supernovae Type Ia (SN Ia) sample with samples from the literature to calculate improved constraints on the dark energy equation of state parameter, w. The CfA3 sample is added to the Union set of Kowalski et al. to form the Constitution set and, combined with a BAO prior, produces 1 + w = 0.013 +0.066 -0.068 (0.11 syst), consistent with the cosmological constant. The CfA3 addition makes the cosmologically useful sample of nearby SN Ia between 2.6 and 2.9 times larger than before, reducing the statistical uncertainty to the point where systematics play the largest role. We use four light-curve fitters to test for systematic differences: SALT, SALT2, MLCS2k2 (R V = 3.1), and MLCS2k2 (R V = 1.7). SALT produces high-redshift Hubble residuals with systematic trends versus color and larger scatter than MLCS2k2. MLCS2k2 overestimates the intrinsic luminosity of SN Ia with 0.7 V = 3.1 overestimates host-galaxy extinction while R V ∼ 1.7 does not. Our investigation is consistent with no Hubble bubble. We also find that, after light-curve correction, SN Ia in Scd/Sd/Irr hosts are intrinsically fainter than those in E/S0 hosts by 2σ, suggesting that they may come from different populations. We also find that SN Ia in Scd/Sd/Irr hosts have low scatter (0.1 mag) and reddening. Current systematic errors can be reduced by improving SN Ia photometric accuracy, by including the CfA3 sample to retrain light-curve fitters, by combining optical SN Ia photometry with near-infrared photometry to understand host-galaxy extinction, and by determining if different environments give rise to different intrinsic SN Ia luminosity after correction for light-curve shape and color.

Preprotachykinin A is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli.

Science.gov (United States)

Gutierrez-Mecinas, Maria; Bell, Andrew M; Marin, Alina; Taylor, Rebecca; Boyle, Kieran A; Furuta, Takahiro; Watanabe, Masahiko; Polgár, Erika; Todd, Andrew J

2017-03-01

The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. We recently defined 3 nonoverlapping populations among the excitatory neurons, based on the expression of neurotensin, neurokinin B, and gastrin-releasing peptide. Here we identify and characterise another population: neurons that express the tachykinin peptide substance P. We show with immunocytochemistry that its precursor protein (preprotachykinin A, PPTA) can be detected in ∼14% of lamina I-II neurons, and these are concentrated in the outer part of lamina II. Over 80% of the PPTA-positive cells lack the transcription factor Pax2 (which determines an inhibitory phenotype), and these account for ∼15% of the excitatory neurons in this region. They are different from the neurotensin, neurokinin B, or gastrin-releasing peptide neurons, although many of them contain somatostatin, which is widely expressed among superficial dorsal horn excitatory interneurons. We show that many of these cells respond to noxious thermal and mechanical stimuli and to intradermal injection of pruritogens. Finally, we demonstrate that these cells can also be identified in a knock-in Cre mouse line (Tac1), although our findings suggest that there is an additional population of neurons that transiently express PPTA. This population of substance P-expressing excitatory neurons is likely to play an important role in the transmission of signals that are perceived as pain and itch.

Constraining Cosmic Evolution of Type Ia Supernovae

Energy Technology Data Exchange (ETDEWEB)

Foley, Ryan J.; Filippenko, Alexei V.; Aguilera, C.; Becker, A.C.; Blondin, S.; Challis, P.; Clocchiatti, A.; Covarrubias, R.; Davis, T.M.; Garnavich, P.M.; Jha, S.; Kirshner, R.P.; Krisciunas, K.; Leibundgut, B.; Li, W.; Matheson, T.; Miceli, A.; Miknaitis, G.; Pignata, G.; Rest, A.; Riess, A.G.; /UC, Berkeley, Astron. Dept. /Cerro-Tololo InterAmerican Obs. /Washington U., Seattle, Astron. Dept. /Harvard-Smithsonian Ctr. Astrophys. /Chile U., Catolica /Bohr Inst. /Notre Dame U. /KIPAC, Menlo Park /Texas A-M /European Southern Observ. /NOAO, Tucson /Fermilab /Chile U., Santiago /Harvard U., Phys. Dept. /Baltimore, Space Telescope Sci. /Johns Hopkins U. /Res. Sch. Astron. Astrophys., Weston Creek /Stockholm U. /Hawaii U. /Illinois U., Urbana, Astron. Dept.

2008-02-13

We present the first large-scale effort of creating composite spectra of high-redshift type Ia supernovae (SNe Ia) and comparing them to low-redshift counterparts. Through the ESSENCE project, we have obtained 107 spectra of 88 high-redshift SNe Ia with excellent light-curve information. In addition, we have obtained 397 spectra of low-redshift SNe through a multiple-decade effort at Lick and Keck Observatories, and we have used 45 ultraviolet spectra obtained by HST/IUE. The low-redshift spectra act as a control sample when comparing to the ESSENCE spectra. In all instances, the ESSENCE and Lick composite spectra appear very similar. The addition of galaxy light to the Lick composite spectra allows a nearly perfect match of the overall spectral-energy distribution with the ESSENCE composite spectra, indicating that the high-redshift SNe are more contaminated with host-galaxy light than their low-redshift counterparts. This is caused by observing objects at all redshifts with similar slit widths, which corresponds to different projected distances. After correcting for the galaxy-light contamination, subtle differences in the spectra remain. We have estimated the systematic errors when using current spectral templates for K-corrections to be {approx}0.02 mag. The variance in the composite spectra give an estimate of the intrinsic variance in low-redshift maximum-light SN spectra of {approx}3% in the optical and growing toward the ultraviolet. The difference between the maximum-light low and high-redshift spectra constrain SN evolution between our samples to be < 10% in the rest-frame optical.

Low-Bit Rate Feedback Strategies for Iterative IA-Precoded MIMO-OFDM-Based Systems

Science.gov (United States)

Teodoro, Sara; Silva, Adão; Dinis, Rui; Gameiro, Atílio

2014-01-01

Interference alignment (IA) is a promising technique that allows high-capacity gains in interference channels, but which requires the knowledge of the channel state information (CSI) for all the system links. We design low-complexity and low-bit rate feedback strategies where a quantized version of some CSI parameters is fed back from the user terminal (UT) to the base station (BS), which shares it with the other BSs through a limited-capacity backhaul network. This information is then used by BSs to perform the overall IA design. With the proposed strategies, we only need to send part of the CSI information, and this can even be sent only once for a set of data blocks transmitted over time-varying channels. These strategies are applied to iterative MMSE-based IA techniques for the downlink of broadband wireless OFDM systems with limited feedback. A new robust iterative IA technique, where channel quantization errors are taken into account in IA design, is also proposed and evaluated. With our proposed strategies, we need a small number of quantization bits to transmit and share the CSI, when comparing with the techniques used in previous works, while allowing performance close to the one obtained with perfect channel knowledge. PMID:24678274

BK polyomavirus genotypes Ia and Ib1 exhibit different biological properties in renal transplant recipients.

Science.gov (United States)

Varella, Rafael B; Zalona, Ana Carolina J; Diaz, Nuria C; Zalis, Mariano G; Santoro-Lopes, Guilherme

2018-01-02

BK polyomavirus (BKV) is an opportunist agent associated with nephropathy (BKVAN) in 1-10% of kidney transplant recipients. BKV is classified into genotypes or subgroups according to minor nucleotidic variations with unknown biological implications. Studies assessing the possible association between genotypes and the risk of BKVAN in kidney transplant patients have presented conflicting results. In these studies, genotype Ia, which is highly prevalent in Brazil, was less frequently found and, thus, comparative data on the biological properties of this genotype are lacking. In this study, BKV Ia and Ib1 genotypes were compared according to their viral load, genetic evolution (VP1 and NCCR) - in a cohort of renal transplant recipients. The patients infected with Ia (13/23; 56.5%) genotype exhibited higher viral loads in urine [>1.4 log over Ib1 (10/23; 43.5%); p=0.025]. In addition, genotype Ia was associated with diverse mutations at VP1 loops and sites under positive selection outside loops, which were totally absent in Ib1. Although the number of viremic patients was similar, the three patients who had BK nephropathy (BKVAN) were infected with Ia genotype. NCCR architecture (ww or rr) were not distinctive between Ia and Ib1 genotypes. Ia genotype, which is rare in other published BKV cohorts, presented some diverse biological properties in transplanted recipients in comparison to Ib1. Copyright © 2017 Elsevier B.V. All rights reserved.

76 FR 52042 - Iowa Disaster #IA-00035

Science.gov (United States)

2011-08-19

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12734 and 12735] Iowa Disaster IA-00035 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Iowa Dated. Incident: Severe Storms and Flash Flooding. Incident...

75 FR 7303 - Union Pacific Railroad Company-Abandonment Exemption-in Polk County, IA

Science.gov (United States)

2010-02-18

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Docket No. AB-33 (Sub-No. 279X)] Union Pacific Railroad Company--Abandonment Exemption--in Polk County, IA Union Pacific Railroad Company... milepost 10.70 in Ankeny, in Polk County, IA. The line traverses United States Postal Service Zip Code...

Asociația Europeană a Profesorilor de Istorie EUROCLIO, La intersecția culturilor. Țările regiunii Marii Negre și schimbările politice din sec. XIX-XX, 2015

Directory of Open Access Journals (Sweden)

Eugen Palade

2016-06-01

Full Text Available Review on two books - Asociația Europeană a Profesorilor de Istorie EUROCLIO, La intersecția culturilor. Țările regiunii Marii Negre și schimbările politice din sec. XIX-XX, 2015

Gene Therapy Vector for the Treatment of Glycogen Storage Disease Type Ia (GSD-Ia) | NCI Technology Transfer Center | TTC

Science.gov (United States)

GSD-Ia is an inherited disorder of metabolism associated with life-threatening hypoglycemia, hepatic malignancy, and renal failure caused by the deficiency of glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC). NICHD seeks parties to license this invention towards commercialization.

Dlouhodobý hmotný majetek dle IAS/IFRS a českých předpisů/Fixed Assets according to IAS/IFRS and Czech Legislation

OpenAIRE

Sladká, Ludmila

2009-01-01

Diploma paper deals with questions of the tangible assets. The first chapter contains determination of the tangible assets and its measurement in term of generally accepted acccounting principles and analyses the depreciation policies. The second chapter focus on the tangible assets in term of International financial reporting standards (IAS/IFRS) especially according to IAS 16 Property, plants and equipment and IFRS 5 Non-current assets held for sale and discontinued operations. The third ch...

Discovering the Nature of Dark Energy: Towards Better Distances from Type Ia Supernovae -- Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

Filippenko, Alexei Vladimir [Univ. of California, Berkeley, CA (United States)

2014-05-09

Type Ia supernovae (SNe Ia; exploding white-dwarf stars) were the key to the Nobel-worthy 1998 discovery and subsequent verification that the expansion of the Universe is accelerating, driven by the effects of dark energy. Understanding the nature of this mysterious, yet dominant, component of the Universe is at the forefront of research in cosmology and fundamental physics. SNe Ia will continue to play a leading role in this enterprise, providing precise cosmological distances that improve constraints on the nature of dark energy. However, for this effort to succeed, we need to more thoroughly understand relatively nearby SNe Ia, because our conclusions come only from comparisons between them and distant (high-redshift) SNe Ia. Thus, detailed studies of relatively nearby SNe Ia are the focus of this research program. Many interesting results were obtained during the course of this project; these were published in 32 refereed research papers that acknowledged the grant. A major accomplishment was the publication of supernova (SN) rates derived from about a decade of operation of the Lick Observatory Supernova Search (LOSS) with the 0.76-meter Katzman Automatic Imaging Telescope (KAIT). We have determined the most accurate rates for SNe of different types in large, nearby galaxies in the present-day Universe, and these can be compared with SN rates far away (and hence long ago in the past) to set constraints on the types of stars that explode. Another major accomplishment was the publication of the light curves (brightness vs. time) of 165 SNe Ia, along with optical spectroscopy of many of these SNe as well as other SNe Ia, providing an extensive, homogeneous database for detailed studies. We have conducted intensive investigations of a number of individual SNe Ia, including quite unusual examples that allow us to probe the entire range of SN explosions and provide unique insights into these objects and the stars before they explode. My team's studies have also

75 FR 7302 - Union Pacific Railroad Company-Abandonment Exemption-in Polk County, IA

Science.gov (United States)

2010-02-18

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Docket No. AB-33 (Sub-No. 248X)] Union Pacific Railroad Company--Abandonment Exemption--in Polk County, IA Union Pacific Railroad Company... 225.56 near Berwick to milepost 232.80 near Bondurant, a distance of 7.24 miles, in Polk County, IA...

76 FR 27738 - Iowa Disaster #IA-00030

Science.gov (United States)

2011-05-12

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12541 and 12542] Iowa Disaster IA-00030 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of Iowa dated 05/04/2011. Incident: Severe storms and tornadoes...

75 FR 51507 - Iowa Disaster #IA-00024

Science.gov (United States)

2010-08-20

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12279 and 12280] Iowa Disaster IA-00024 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Iowa (FEMA-1930-DR), dated 08/14/2010. Incident: Severe...

75 FR 10329 - Iowa Disaster #IA-00022

Science.gov (United States)

2010-03-05

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12053 and 12054] Iowa Disaster IA-00022 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of IOWA (FEMA--1877-- DR), dated 02...

76 FR 66768 - Iowa Disaster #IA-00033

Science.gov (United States)

2011-10-27

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12895 and 12896] Iowa Disaster IA-00033 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Iowa (FEMA-1998-DR), dated 10/18/2011. Incident: Flooding...

75 FR 53006 - Iowa Disaster #IA-00026

Science.gov (United States)

2010-08-30

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1930-DR...

Clinical Outcomes in International Federation of Gynecology and Obstetrics Stage IA Endometrial Cancer With Myometrial Invasion Treated With or Without Postoperative Vaginal Brachytherapy

Energy Technology Data Exchange (ETDEWEB)

Diavolitsis, V. [Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL (United States); Rademaker, A. [Department of Preventive Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL (United States); Lurain, J.; Hoekstra, A. [Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL (United States); Strauss, J. [Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL (United States); Small, W., E-mail: wsmall@nmff.org [Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL (United States)

2012-10-01

Purpose: To assess the clinical outcomes of patients with Stage IA endometrial cancer with myometrial invasion treated with postoperative vaginal brachytherapy (VBT) with those who received no adjuvant therapy (NAT). Methods and Materials: All patients treated with hysterectomy for endometrial cancer at Northwestern Memorial Hospital between 1978 and 2005 were identified. Those patients with Stage IA disease with myometrial invasion who were treated with VBT alone or NAT were identified and included in the present analysis. Results: Of 252 patients with Stage IA endometrial cancer with superficial (<50%) myometrial invasion who met the inclusion criteria, 169 underwent VBT and 83 received NAT. The median follow-up in the VBT and NAT groups was 103 and 61 months, respectively. In the VBT group, 56.8% had Grade 1, 37.9% had Grade 2, and 5.3% had Grade 3 tumors. In the NAT group, 75.9%, 20.5%, and 3.6% had Grade 1, 2, and 3 tumors, respectively. Lymphatic or vascular space invasion was noted in 12.4% of the VBT patients and 5.6% of the NAT patients. The 5-year overall survival rate was 95.5%. The 5-year recurrence-free survival rate was 92.4% for all patients, 94.4% for the VBT group, and 87.4% for the NAT group (p = NS). Of the 169 VBT patients and 83 NAT patients, 8 (4.7%) and 6 (7.2%) developed recurrent disease. One vaginal recurrence occurred in the VBT group (0.6%) and three in the NAT group (3.8%). Recurrences developed 2-102 months after surgical treatment. Two of the four vaginal recurrences were salvaged. No Grade 3 or higher acute or late radiation toxicity was noted. Conclusions: The use of postoperative VBT in patients with Stage I endometrial cancer with <50% myometrial invasion yielded excellent vaginal disease control and disease-free survival, with minimal toxicity.

TYPE Ia SNe ALONG REDSHIFT: THE R(Si II) RATIO AND THE EXPANSION VELOCITIES IN INTERMEDIATE-z SUPERNOVAE

International Nuclear Information System (INIS)

Altavilla, G.; Ruiz-Lapuente, P.; Balastegui, A.; Mendez, J.; Espana-Bonet, C.; Irwin, M.; Ellis, R. S.; McMahon, R. M.; Walton, N. A.; Folatelli, G.; Goobar, A.; Nobili, S.; Stanishev, V.; Hillebrandt, W.

2009-01-01

We present a study of intermediate-z Type Ia supernovae (SNe Ia) using empirical physical diagrams which permit the investigation of those SNe explosions. This information can be very useful to reduce systematic uncertainties of the Hubble diagram of SNe Ia up to high z. The study of the expansion velocities and the measurement of the ratio R(Si II) allow subtyping of SNe Ia as done in nearby samples. The evolution of this ratio as seen in the diagram R(Si II)-(t) together with R(Si II) max versus (B - V) 0 indicates consistency of the properties at intermediate-z compared with the nearby SNe Ia. At intermediate-z, expansion velocities of Ca II and Si II are found similar to those of the nearby sample. This is found in a sample of six SNe Ia in the range 0.033 ≤z≤ 0.329 discovered within the International Time Programme of SNe Ia for Cosmology and Physics in the spring run of 2002. 7 The program run under Omega and Lambda from Supernovae and the Physics of Supernova Explosions within the International Time Programme at the telescopes of the European Northern Observatory (ENO) at La Palma (Canary Islands, Spain). Two SNe Ia at intermediate-z were of the cool FAINT type, one being an SN1986G-like object highly reddened. The R(Si II) ratio as well as subclassification of the SNe Ia beyond templates help to place SNe Ia in their sequence of brightness and to distinguish between reddened and intrinsically red supernovae. This test can be done with very high z SNe Ia and it will help to reduce systematic uncertainties due to extinction by dust. It should allow to map the high-z sample into the nearby one.

Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers

DEFF Research Database (Denmark)

Sherson, D; Sigsgaard, T; Overgaard, E

1992-01-01

.56-5.24). The same was true for smoking controls and foundry workers (9.10, 95% CI 8.00-10.20 and 8.69, 95% CI 7.37-10.01). Both smoking groups had raised IA2 ratios compared with non-smokers (p less than 0.01). Non-smoking controls and foundry workers had similar hpU concentrations (0.16, 95% CI 0.10-0.22 and 0...... hygienic samples (respirable dust 1.2 to 3.52 mg/m3 (93 samples)) and as total PAH (0.46 micrograms/m3) and pyrene concentrations (0.28 micrograms/m3) (six samples). Non-smoking controls and foundry workers had similar IA2 ratios (5.63, 95% confidence interval (95% CI) 4.56-6.70 and 4.40, 95% CI 3...

HUBBLE RESIDUALS OF NEARBY TYPE Ia SUPERNOVAE ARE CORRELATED WITH HOST GALAXY MASSES

International Nuclear Information System (INIS)

Kelly, Patrick L.; Burke, David L.; Hicken, Malcolm; Mandel, Kaisey S.; Kirshner, Robert P.

2010-01-01

From Sloan Digital Sky Survey u'g'r'i'z' imaging, we estimate the stellar masses of the host galaxies of 70 low-redshift Type Ia supernovae (SNe Ia, 0.015 10.8 M sun in a cosmology fit yields 1 + w = 0.22 +0.152 -0.108 , while a combination where the 30 nearby SNe instead have host masses greater than 10 10.8 M sun yields 1 + w = -0.03 +0.217 -0.143 . Progenitor metallicity, stellar population age, and dust extinction correlate with galaxy mass and may be responsible for these systematic effects. Host galaxy measurements will yield improved distances to SNe Ia.

IAS/IFRS and Financial Reporting Quality: Lessons from the European Experience.

OpenAIRE

Palea, Vera

2013-01-01

This paper discusses the effects of the adoption of IAS/IFRS in Europe on the quality of financial reporting. In doing so, it adopts the perspective of stock market investors and focuses on value-relevance research. The adoption of IAS/IFRS in Europe is an example of accounting standardization among countries with different institutional frameworks and enforcement rules. This allows investigating whether, and to what extent, accounting regulation per se can affect the quality of financial rep...

Evidence for a Sub-Chandrasekhar-mass Type Ia Supernova in the Ursa Minor Dwarf Galaxy

Science.gov (United States)

McWilliam, Andrew; Piro, Anthony L.; Badenes, Carles; Bravo, Eduardo

2018-04-01

A long-standing problem is identifying the elusive progenitors of Type Ia supernovae (SNe Ia), which can roughly be split into Chandraksekhar and sub-Chandrasekhar-mass events. An important difference between these two cases is the nucleosynthetic yield, which is altered by the increased neutron excess in Chandrasekhar progenitors due to their pre-explosion simmering and high central density. Based on these arguments, we show that the chemical composition of the most metal-rich star in the Ursa Minor dwarf galaxy, COS 171, is dominated by nucleosynthesis from a low-metallicity, low-mass, sub-Chandrasekhar-mass SN Ia. Key diagnostic abundance ratios include Mn/Fe and Ni/Fe, which could not have been produced by a Chandrasekhar-mass SN Ia. Large deficiencies of Ni/Fe, Cu/Fe and Zn/Fe also suggest the absence of alpha-rich freeze-out nucleosynthesis, favoring low-mass white dwarf progenitors of SNe Ia, near 0.95 M ⊙, from comparisons to numerical detonation models. We also compare Mn/Fe and Ni/Fe ratios to the recent yields predicted by Shen et al., finding consistent results. To explain the [Fe/H] at ‑1.35 dex for COS 171 would require dilution of the SN Ia ejecta with ∼104 M ⊙ of material, which is expected for an SN remnant expanding into a warm interstellar medium with n ∼ 1 cm‑3. In the future, finding more stars with the unique chemical signatures we highlight here will be important for constraining the rate and environments of sub-Chandrasekhar SNe Ia.

THE PROGENITORS OF TYPE Ia SUPERNOVAE. I. ARE THEY SUPERSOFT SOURCES?

International Nuclear Information System (INIS)

Di Stefano, R.

2010-01-01

In a canonical model, the progenitors of Type Ia supernovae (SNe Ia) are accreting, nuclear-burning white dwarfs (NBWDs), which explode when the white dwarf reaches the Chandrasekhar mass, M C . Such massive NBWDs are hot (kT ∼ 100 eV), luminous (L ∼ 10 38 erg s -1 ), and are potentially observable as luminous supersoft X-ray sources (SSSs). During the past several years, surveys for soft X-ray sources in external galaxies have been conducted. This paper shows that the results falsify the hypothesis that a large fraction of progenitors are NBWDs which are presently observable as SSSs. The data also place limits on sub-M C models. While SN Ia progenitors may pass through one or more phases of SSS activity, these phases are far shorter than the time needed to accrete most of the matter that brings them close to M C .

Progressive Red Shifts in the Late-Time Spectra of Type Ia Supernovae

Science.gov (United States)

Black, Christine; Fesen, Robert; Parrent, Jerod

2017-01-01

We examine the evolution of late-time, optical nebular features of Type Ia supernovae (SNe Ia) using a sample consisting of 160 spectra of 27 normal SNe Ia taken from the literature as well as unpublished spectra of SN 2008Q and ASASSN-14lp. Particular attention is given to nebular features between 4000-6000 Ang in terms of temporal changes in width and central wavelength. Analysis of the prominent late-time 4700 Ang feature shows a progressive central wavelength shift from ˜4600 Ang to longer wavelengths out to at least day +300 for our entire sample. We find no evidence for the feature’s red-ward shift slowing or halting at an [Fe III] blend centroid ˜4700 Ang as has been proposed. Two weaker adjacent features at around 4850 and 5000 Ang exhibit similar red shifts to that of the 4700 Ang feature. We conclude that the ubiquitous red shift of these common late-time SN Ia spectral features is not mainly due to a decrease in line velocities of forbidden Fe emissions, but the result of decreasing line velocities and opacity of permitted Fe absorption lines.

Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia.

Science.gov (United States)

Cho, Jun-Ho; Kim, Goo-Young; Mansfield, Brian C; Chou, Janice Y

2018-05-08

Glycogen storage disease type Ia (GSD-Ia) deficient in glucose-6-phosphatase-α (G6Pase-α) is a metabolic disorder characterized by impaired glucose homeostasis and a long-term complication of hepatocellular adenoma/carcinoma (HCA/HCC). Mitochondrial dysfunction has been implicated in GSD-Ia but the underlying mechanism and its contribution to HCA/HCC development remain unclear. We have shown that hepatic G6Pase-α deficiency leads to downregulation of sirtuin 1 (SIRT1) signaling that underlies defective hepatic autophagy in GSD-Ia. SIRT1 is a NAD + -dependent deacetylase that can deacetylate and activate peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), a master regulator of mitochondrial integrity, biogenesis, and function. We hypothesized that downregulation of hepatic SIRT1 signaling in G6Pase-α-deficient livers impairs PGC-1α activity, leading to mitochondrial dysfunction. Here we show that the G6Pase-α-deficient livers display defective PGC-1α signaling, reduced numbers of functional mitochondria, and impaired oxidative phosphorylation. Overexpression of hepatic SIRT1 restores PGC-1α activity, normalizes the expression of electron transport chain components, and increases mitochondrial complex IV activity. We have previously shown that restoration of hepatic G6Pase-α expression normalized SIRT1 signaling. We now show that restoration of hepatic G6Pase-α expression also restores PGC-1α activity and mitochondrial function. Finally, we show that HCA/HCC lesions found in G6Pase-α-deficient livers contain marked mitochondrial and oxidative DNA damage. Taken together, our study shows that downregulation of hepatic SIRT1/PGC-1α signaling underlies mitochondrial dysfunction and that oxidative DNA damage incurred by damaged mitochondria may contribute to HCA/HCC development in GSD-Ia.

Biochemistry of an olfactory purinergic system: dephosphorylation of excitatory nucleotides and uptake of adenosine

Energy Technology Data Exchange (ETDEWEB)

Trapido-Rosenthal, H G; Carr, W E; Gleeson, R A

1987-10-01

The olfactory organ of the spiny lobster, Panulirus argus, is composed of chemosensory sensilla containing the dendrites of primary chemosensory neurons. Receptors on these dendrites are activated by the nucleotides AMP, ADP, and ATP but not by the nucleoside adenosine. It is shown here that the lobster chemosensory sensilla contain enzymes that dephosphorylate excitatory nucleotides and an uptake system that internalizes the nonexcitatory dephosphorylated product adenosine. The uptake of (/sup 3/H)-adenosine is saturable with increasing concentration, linear with time for up to 3 h, sodium dependent, insensitive to moderate pH changes and has a Km of 7.1 microM and a Vmax of 5.2 fmol/sensillum/min (573 fmol/micrograms of protein/min). Double-label experiments show that sensilla dephosphorylate nucleotides extracellularly; /sup 3/H from adenine-labeled AMP or ATP is internalized, whereas 32P from phosphate-labeled nucleotides is not. The dephosphorylation of AMP is very rapid; /sup 3/H from AMP is internalized at the same rate as /sup 3/H from adenosine. Sensillar 5'-ectonucleotidase activity is inhibited by ADP and the ADP analog alpha, beta-methylene ADP. Collectively, these results indicate that the enzymes and the uptake system whereby chemosensory sensilla of the lobster inactivate excitatory nucleotides and clear adenosine from extracellular spaces are very similar to those present in the internal tissues of vertebrates, where nucleotides have many neuroactive effects.

78 FR 36010 - Iowa Disaster #IA-00052

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2013-06-14

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13605 and 13606] Iowa Disaster IA-00052 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-4119- DR), dated 05/31...

76 FR 54522 - Iowa Disaster #IA-00037

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2011-09-01

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12760 and 12761] Iowa Disaster IA-00037 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-4016- DR), dated 08/24...

78 FR 28939 - Iowa Disaster #IA-00050

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2013-05-16

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13567 and 13568] Iowa Disaster IA-00050 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-4114- DR), dated 05/06...

76 FR 55721 - Iowa Disaster #IA-00038

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2011-09-08

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12772 and 12773] Iowa Disaster IA-00038 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-4018- DR), dated 08/30...

75 FR 47035 - Iowa Disaster # IA-00026

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2010-08-04

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance only for the State of Iowa (FEMA-1930- DR), dated 07/29...

75 FR 11582 - IOWA Disaster # IA-00023

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2010-03-11

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12062 and 12063] IOWA Disaster IA-00023 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-1880- DR), dated 03/02...

78 FR 42147 - Iowa Disaster #IA-00054

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2013-07-15

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13645 and 13646] Iowa Disaster IA-00054 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance only for the State of Iowa (FEMA-4126- DR), dated 07/02...

76 FR 29284 - Iowa Disaster #IA-00031

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2011-05-20

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12568 and 12569] Iowa Disaster IA-00031 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-1977- DR), dated 05/05...

75 FR 45681 - Iowa Disaster #IA-00025

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2010-08-03

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12252 and 12253] Iowa Disaster IA-00025 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-1928- DR), dated 07/27...

78 FR 48762 - Iowa Disaster #IA-00053

Science.gov (United States)

2013-08-09

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13699 and 13700] Iowa Disaster IA-00053 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA-4135- DR), dated 07/31...

Role of cytochrome P450 IA2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies.

Science.gov (United States)

Liu, G; Gelboin, H V; Myers, M J

1991-02-01

The role of P450 IA2 in the hydroxylation of acetanilide was examined using an inhibitory monoclonal antibody (MAb) 1-7-1 and vaccinia cDNA expression producing murine P450 IA1 (mIA1), murine P450 IA2 (mIA2), or human P450 IA2 (hIA2). Acetanilide hydroxylase (AcOH) activity was measured using an HPLC method with more than 500-fold greater sensitivity than previously described procedures. This method, which does not require the use of radioactive acetanilide, was achieved by optimizing both the gradient system and the amount of enzyme needed to achieve detection by uv light. MAb 1-7-1 inhibits up to 80% of the AcOH activity in both rat liver microsomes and cDNA expressed mouse and human P450 IA2. MAb 1-7-1, which recognizes both P450 IA1 and P450 IA2, completely inhibits the aryl hydrocarbon hydroxylase (AHH) activity of cDNA expressed in IA1. The inhibition of only 80% of the AHH activity present in MC liver microsomes by MAb 1-7-1 suggests that additional P450 forms are contributing to the overall AHH activity present in methylcholanthrene (MC)-liver microsomes as MAb 1-7-1 almost completely inhibits the AHH activity of expressed mIA1. Maximal inhibition of IA2 by 1-7-1 results in an 80% decrease in acetanilide hydroxylase activity in both liver microsomes and expressed mouse and human IA2. The capacity of MAb 1-7-1 to produce identical levels of inhibition of acetanilide hydroxylase activity in rat MC microsomes (80%) and in expressed mouse (81%) and human P450 IA2 (80%) strongly suggests that P450 IA2 is the major and perhaps the only enzyme responsible for the metabolism of acetanilide. These results demonstrate the complementary utility of monoclonal antibodies and cDNA expression for defining the contribution of specific P450 enzymes to the metabolism of a given substrate. This complementary approach allows for a more precise determination of the inhibitory capacity of MAb with respect to the metabolic capacity of the target P450.

Type Ia supernovae as speed sensors at intermediate redshifts

International Nuclear Information System (INIS)

Zhang Pengjie; Chen Xuelei

2008-01-01

Large scale peculiar velocity (LSPV) is a crucial probe of dark matter, dark energy, and gravity at cosmological scales. However, its application is severely limited by measurement obstacles. We show that fluctuations in type Ia supernovae fluxes induced by LSPV offer a promising approach to measure LSPV at intermediate redshifts. In the 3D Fourier space, gravitational lensing, the dominant systematical error, is well suppressed, localized, and can be further corrected effectively. Advances in supernova observations can further significantly reduce shot noise induced by supernova intrinsic fluctuations, which is the dominant statistical error. Robust mapping on the motion of the dark universe through type Ia supernovae is thus feasible to z∼0.5.

Enhancement of the intrinsic defecation reflex by mosapride, a 5-HT4 agonist, in chronically lumbosacral denervated guinea pigs.

Science.gov (United States)

Kojima, Yu; Fujii, Hisao; Katsui, Renta; Nakajima, Yoshiyuki; Takaki, Miyako

2006-10-01

The defecation reflex is composed of rectal distension-evoked rectal (R-R) reflex contractions and synchronous internal anal sphincter (R-IAS) reflex relaxations in guinea pigs. These R-R and R-IAS reflexes are controlled via extrinsic sacral excitatory nerve pathway (pelvic nerves), lumbar inhibitory nerve pathways (colonic nerves) and by intrinsic cholinergic excitatory and nitrergic inhibitory nerve pathways. The effect of mosapride (a prokinetic benzamide) on the intrinsic reflexes, mediated via enteric 5-HT(4) receptors, was evaluated by measuring the mechanical activity of the rectum and IAS in anesthetized guinea pigs using an intrinsic R-R and R-IAS reflex model resulting from chronic (two to nine days) lumbosacral denervation (PITH). In this model, the myenteric plexus remains undamaged and the distribution of myenteric and intramuscular interstitial cells of Cajal is unchanged. Although R-R and R-IAS reflex patterns markedly changed, the reflex indices (reflex pressure or force curve-time integral) of both the R-R contractions and the synchronous R-IAS relaxations were unchanged. The frequency of the spontaneous R and IAS motility was also unchanged. Mosapride (0.1-1.0 mg/kg) dose-dependently increased both intrinsic R-R (maximum: 1.82) and R-IAS reflex indices (maximum: 2.76) from that of the control (1.0) 6-9 days following chronic PITH. The dose-response curve was similar to that in the intact guinea pig, and had shifted to the left from that in the guinea pig after acute PITH. A specific 5-HT(4) receptor antagonist, GR 113808 (1.0 mg/kg), decreased both reflex indices by approximately 50% and antagonized the effect of mosapride 1.0 mg/kg. This was quite different from the result in the intact guinea pig where GR 113808 (1.0 mg/kg) did not affect either of the reflex indices. The present results indicate that mosapride enhanced the intrinsic R-R and R-IAS reflexes and functionally compensated for the deprivation of extrinsic innervation. The actions of

Terapêutica hormonal na coréia de Sydenham

Directory of Open Access Journals (Sweden)

José Geraldo Albernaz

1957-09-01

Full Text Available Cinco casos de coréia de Sydenham foram submetidos à terapêutica hormonal com Cortisona, Prednisona e Prednisolona; o fenobarbital e a clorpromazina foram utilizados como medicação sintomática e a Penicilina-Benzatina como profilática. Depois de analisadas as referências bibliográficas, comparados os resultados de ν;rios autores, e ajuizados os resultados obtidos em nossos casos, acreditamos poder concluir que: 1 a terapêutica hormonal da coréia de Sydenham, com o uso de ACTH, Cortisona, Prednisona ou Pred-nisclona apresenta resultados satisfatórios; 2 a Prednisona e a Prednisolona são os hormônios mais úteis no tratamento da coréia de Sydenham, sendo possível que sua associação aos salicilatos permita obter resultados ainda melhores; 3 o tratamento deve prolongar-se até o completo desaparecimento dos sintomas, as doses variando de acôrdo com a gravidade e a evolução da moléstia; 4 a terapêutica hormonal deve ser usada sem prejuízo de medicação sintomática (sedativa e profilática (antibiótica.

Testing the single degenerate channel for supernova Ia

Science.gov (United States)

Parsons, Steven

2014-10-01

The progenitors of supernova Ia are close binaries containing white dwarfs. Of crucial importance to the evolution of these systems is how much material the white dwarf can stably accrete and hence grow in mass. This occurs during a short-lived intense phase of mass transfer known as the super soft source (SSS) phase. The short duration of this phase and large extinction to soft X-rays means that only a handful are known in our Galaxy. Far more can be learned from the underlying SSS progenitor population of close white dwarf plus FGK type binaries. Unfortunately, these systems are hard to find since the main-sequence stars completely outshine the white dwarfs at optical wavelengths. Because of this, there are currently no known close white dwarf binaries with F, G or early K type companions, making it impossible to determine the contribution of the single degenerate channel towards supernova Ia. Using the GALEX and RAVE surveys we have now identified the first large sample of FGK stars with UV excesses, a fraction of which are these illusive, close systems. Following an intense ground based spectroscopic investigation of these systems, we have identified 5 definite close binaries, with periods of less than a few days. Here we apply for COS spectroscopic observations to measure the mass and temperature of the white dwarfs in order to determine the future evolution of these systems. This will provide a crucial test for the single degenerate channel towards supernova Ia.

RadNet Air Data From Mason City, IA

Science.gov (United States)

This page presents radiation air monitoring and air filter analysis data for Mason City, IA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

Neonatal Nicotine Exposure Increases Excitatory Synaptic Transmission and Attenuates Nicotine-stimulated GABA release in the Adult Rat Hippocampus

Science.gov (United States)

Damborsky, Joanne C.; Griffith, William H.; Winzer-Serhan, Ursula H.

2014-01-01

Developmental exposure to nicotine has been linked to long-lasting changes in synaptic transmission which may contribute to behavioral abnormalities seen in offspring of women who smoke during pregnancy. Here, we examined the long-lasting effects of developmental nicotine exposure on glutamatergic and GABAergic neurotransmission, and on acute nicotine-induced glutamate and GABA release in the adult hippocampus, a structure important in cognitive and emotional behaviors. We utilized a chronic neonatal nicotine treatment model to administer nicotine (6 mg/kg/day) to rat pups from postnatal day (P) 1–7, a period that falls developmentally into the third human trimester. Using whole-cell voltage clamp recordings from CA1 pyramidal neurons in hippocampal slices, we measured excitatory and inhibitory postsynaptic currents in neonatally control- and nicotine-treated young adult males. Neonatal nicotine exposure significantly increased AMPA receptor-mediated spontaneous and evoked excitatory signaling, with no change in glutamate release probability in adults. Conversely, there was no increase in spontaneous GABAergic neurotransmission in nicotine-males. Chronic neonatal nicotine treatment had no effect on acute nicotine-stimulated glutamate release in adults, but acute nicotine-stimulated GABA release was significantly attenuated. Thus, neonatal nicotine exposure results in a persistent net increase in excitation and a concurrent loss of nicotinic acetylcholine receptor (nAChR)-mediated regulation of presynaptic GABA but not glutamate release, which would exacerbate excitation following endogenous or exogenous nAChR activation. Our data underscore an important role for nAChRs in hippocampal excitatory synapse development, and suggest selective long-term changes at specific presynaptic nAChRs which together could explain some of the behavioral abnormalities associated with maternal smoking. PMID:24950455

Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics

Directory of Open Access Journals (Sweden)

Craik David J

2007-04-01

Full Text Available Abstract Background α-Conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in α-conotoxins is variable, leading to the classification of sub-families. BuIA is the only α-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin. Results In the current study we show the native globular disulfide connectivity of BuIA displays multiple conformations in solution whereas the non-native ribbon isomer has a single well-defined conformation. Despite having multiple conformations in solution the globular form of BuIA displays activity at the nicotinic acetylcholine receptor, contrasting with the lack of activity of the structurally well-defined ribbon isomer. Conclusion These findings are opposite to the general trends observed for α-conotoxins where the native isomers have well-defined structures and the ribbon isomers are generally disordered. This study thus highlights the influence of the disulfide connectivity of BuIA on the dynamics of the three-dimensional structure.

The Complete Light-curve Sample of Spectroscopically Confirmed SNe Ia from Pan-STARRS1 and Cosmological Constraints from the Combined Pantheon Sample

Science.gov (United States)

Scolnic, D. M.; Jones, D. O.; Rest, A.; Pan, Y. C.; Chornock, R.; Foley, R. J.; Huber, M. E.; Kessler, R.; Narayan, G.; Riess, A. G.; Rodney, S.; Berger, E.; Brout, D. J.; Challis, P. J.; Drout, M.; Finkbeiner, D.; Lunnan, R.; Kirshner, R. P.; Sanders, N. E.; Schlafly, E.; Smartt, S.; Stubbs, C. W.; Tonry, J.; Wood-Vasey, W. M.; Foley, M.; Hand, J.; Johnson, E.; Burgett, W. S.; Chambers, K. C.; Draper, P. W.; Hodapp, K. W.; Kaiser, N.; Kudritzki, R. P.; Magnier, E. A.; Metcalfe, N.; Bresolin, F.; Gall, E.; Kotak, R.; McCrum, M.; Smith, K. W.

2018-06-01

We present optical light curves, redshifts, and classifications for 365 spectroscopically confirmed Type Ia supernovae (SNe Ia) discovered by the Pan-STARRS1 (PS1) Medium Deep Survey. We detail improvements to the PS1 SN photometry, astrometry, and calibration that reduce the systematic uncertainties in the PS1 SN Ia distances. We combine the subset of 279 PS1 SNe Ia (0.03 Ia from the Sloan Digital Sky Survey (SDSS), SNLS, and various low-z and Hubble Space Telescope samples to form the largest combined sample of SNe Ia, consisting of a total of 1048 SNe Ia in the range of 0.01 Ia to measure dark energy.

Observational Evidence for High Neutronization in Supernova Remnants: Implications for Type Ia Supernova Progenitors

International Nuclear Information System (INIS)

Martínez-Rodríguez, Héctor; Badenes, Carles; Andrews, Brett; Yamaguchi, Hiroya; Bravo, Eduardo; Timmes, F. X.; Miles, Broxton J.; Townsley, Dean M.; Piro, Anthony L.; Mori, Hideyuki; Park, Sangwook

2017-01-01

The physical process whereby a carbon–oxygen white dwarf explodes as a Type Ia supernova (SN Ia) remains highly uncertain. The degree of neutronization in SN Ia ejecta holds clues to this process because it depends on the mass and the metallicity of the stellar progenitor, and on the thermodynamic history prior to the explosion. We report on a new method to determine ejecta neutronization using Ca and S lines in the X-ray spectra of Type Ia supernova remnants (SNRs). Applying this method to Suzaku data of Tycho, Kepler , 3C 397, and G337.2−0.7 in the Milky Way, and N103B in the Large Magellanic Cloud, we find that the neutronization of the ejecta in N103B is comparable to that of Tycho and Kepler , which suggests that progenitor metallicity is not the only source of neutronization in SNe Ia. We then use a grid of SN Ia explosion models to infer the metallicities of the stellar progenitors of our SNRs. The implied metallicities of 3C 397, G337.2−0.7, and N103B are major outliers compared to the local stellar metallicity distribution functions, indicating that progenitor metallicity can be ruled out as the origin of neutronization for these SNRs. Although the relationship between ejecta neutronization and equivalent progenitor metallicity is subject to uncertainties stemming from the 12 C + 16 O reaction rate, which affects the Ca/S mass ratio, our main results are not sensitive to these details.

Observational Evidence for High Neutronization in Supernova Remnants: Implications for Type Ia Supernova Progenitors

Energy Technology Data Exchange (ETDEWEB)

Martínez-Rodríguez, Héctor; Badenes, Carles; Andrews, Brett [Department of Physics and Astronomy and Pittsburgh Particle Physics, Astrophysics and Cosmology Center (PITT PACC), University of Pittsburgh, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Yamaguchi, Hiroya [NASA Goddard Space Flight Center, Code 662, Greenbelt, MD 20771 (United States); Bravo, Eduardo [E.T.S. Arquitectura del Vallès, Universitat Politècnica de Catalunya, Carrer Pere Serra 1-15, E-08173 Sant Cugat del Vallès (Spain); Timmes, F. X. [The Joint Institute for Nuclear Astrophysics (United States); Miles, Broxton J.; Townsley, Dean M. [Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL (United States); Piro, Anthony L. [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Mori, Hideyuki [CRESST and X-ray Astrophysics Laboratory, NASA Goddard Space Flight Center, Code 602, Greenbelt, MD 20771 (United States); Park, Sangwook, E-mail: hector.mr@pitt.edu [Department of Physics, University of Texas at Arlington, Box 19059, Arlington, TX 76019 (United States)

2017-07-01

The physical process whereby a carbon–oxygen white dwarf explodes as a Type Ia supernova (SN Ia) remains highly uncertain. The degree of neutronization in SN Ia ejecta holds clues to this process because it depends on the mass and the metallicity of the stellar progenitor, and on the thermodynamic history prior to the explosion. We report on a new method to determine ejecta neutronization using Ca and S lines in the X-ray spectra of Type Ia supernova remnants (SNRs). Applying this method to Suzaku data of Tycho, Kepler , 3C 397, and G337.2−0.7 in the Milky Way, and N103B in the Large Magellanic Cloud, we find that the neutronization of the ejecta in N103B is comparable to that of Tycho and Kepler , which suggests that progenitor metallicity is not the only source of neutronization in SNe Ia. We then use a grid of SN Ia explosion models to infer the metallicities of the stellar progenitors of our SNRs. The implied metallicities of 3C 397, G337.2−0.7, and N103B are major outliers compared to the local stellar metallicity distribution functions, indicating that progenitor metallicity can be ruled out as the origin of neutronization for these SNRs. Although the relationship between ejecta neutronization and equivalent progenitor metallicity is subject to uncertainties stemming from the {sup 12}C + {sup 16}O reaction rate, which affects the Ca/S mass ratio, our main results are not sensitive to these details.

Prognostic Significance of Clinical/Pathological Stage IA Non-Small-Cell Lung Cancer Showing Partially Solid or Solid Tumours on Radiological Exam

Science.gov (United States)

Matsuura, Yosuke; Nakao, Masayuki; Mun, Mingyon; Nakagawa, Ken; Ishikawa, Yuichi; Okumura, Sakae

2015-01-01

Purpose: Although curative resection is expected to be effective in patients with clinical (c-) stage IA/pathological (p-) stage IA non-small-cell lung cancers, recurrence is often observed. Hence, the aim of this study was to identify predictors of recurrence. Methods: Between 2005 and 2009, 138 patients with c-stage IA/p-stage IA non-small-cell lung cancers underwent resection. Recurrence and recurrence-free survival (RFS) were compared with clinical, radiographic and pathological findings. Results: The 5-year cancer-specific survival rate was 97% and the RFS rate was 89% at a median follow-up time of 91 months. Recurrence was observed in 10 patients (7.2%). Significant differences were observed in RFS according to tumour dimensions on the mediastinal window image (>1.5 cm), serum carcinoembryonic antigen levels (>5.0 ng/mL), maximum standardised uptake values (SUVmax >2.5) and angiolymphatic invasion. Patients were grouped according to the number of risk factors for poor RFS. Patients with 0–1 of the identified risk factors had an RFS of 97%, where those with 2–4 factors had an RFS of 68% (p <0.001). Conclusion: Prognosis of patients exhibiting more than two of these risk factors is considerably poor. Thus, close observation and individualised adjuvant therapy may be beneficial to these patients. PMID:25740451

Adeno-Associated Virus-Mediated Correction of a Canine Model of Glycogen Storage Disease Type Ia

OpenAIRE

Weinstein, David A.; Correia, Catherine E.; Conlon, Thomas; Specht, Andrew; Verstegen, John; Onclin-Verstegen, Karine; Campbell-Thompson, Martha; Dhaliwal, Gurmeet; Mirian, Layla; Cossette, Holly; Falk, Darin J.; Germain, Sean; Clement, Nathalie; Porvasnik, Stacy; Fiske, Laurie

2010-01-01

This study by the groups of Drs. Barry Byrne and Cathryn Mah at the University of Florida examines the safety and efficacy of AAV-mediated gene delivery in a canine model of glycogen storage disease type Ia (GSDIa). The authors find that intraportal delivery of AAV8 encoding glucose-6-phosphatase-α (G6Pase) followed 20 weeks later by intraportal administration of AAV1 encoding G6Pase led to significant correction of the GSDIa phenotype.

Two transitional type Ia supernovae located in the Fornax cluster member NGC 1404

DEFF Research Database (Denmark)

Gall, C.; Stritzinger, M. D.; Ashall, C.

2018-01-01

We present an analysis of ultraviolet (UV) to near-infrared observations of the fast-declining Type Ia supernovae (SNe Ia) 2007on and 2011iv, hosted by the Fornax cluster member NGC 1404. The B-band light curves of SN 2007on and SN 2011iv are characterised by Delta m(15)(B) decline-rate values of...

Type-Ia supernova rates to redshift 2.4 from clash: The cluster lensing and supernova survey with Hubble

International Nuclear Information System (INIS)

Graur, O.; Rodney, S. A.; Riess, A. G.; Medezinski, E.; Maoz, D.; Jha, S. W.; Holoien, T. W.-S.; McCully, C.; Patel, B.; Postman, M.; Dahlen, T.; Strolger, L.-G.; Coe, D.; Bradley, L.; Koekemoer, A.; Benítez, N.; Molino, A.; Jouvel, S.; Nonino, M.; Balestra, I.

2014-01-01

We present the supernova (SN) sample and Type-Ia SN (SN Ia) rates from the Cluster Lensing And Supernova survey with Hubble (CLASH). Using the Advanced Camera for Surveys and the Wide Field Camera 3 on the Hubble Space Telescope (HST), we have imaged 25 galaxy-cluster fields and parallel fields of non-cluster galaxies. We report a sample of 27 SNe discovered in the parallel fields. Of these SNe, ∼13 are classified as SN Ia candidates, including four SN Ia candidates at redshifts z > 1.2. We measure volumetric SN Ia rates to redshift 1.8 and add the first upper limit on the SN Ia rate in the range 1.8 < z < 2.4. The results are consistent with the rates measured by the HST/GOODS and Subaru Deep Field SN surveys. We model these results together with previous measurements at z < 1 from the literature. The best-fitting SN Ia delay-time distribution (DTD; the distribution of times that elapse between a short burst of star formation and subsequent SN Ia explosions) is a power law with an index of −1.00 −0.06(0.10) +0.06(0.09) (statistical) −0.08 +0.12 (systematic), where the statistical uncertainty is a result of the 68% and 95% (in parentheses) statistical uncertainties reported for the various SN Ia rates (from this work and from the literature), and the systematic uncertainty reflects the range of possible cosmic star-formation histories. We also test DTD models produced by an assortment of published binary population synthesis (BPS) simulations. The shapes of all BPS double-degenerate DTDs are consistent with the volumetric SN Ia measurements, when the DTD models are scaled up by factors of 3-9. In contrast, all BPS single-degenerate DTDs are ruled out by the measurements at >99% significance level.

EnviroAtlas - Woodbine, IA - Ecosystem Services by Block Group

Data.gov (United States)

U.S. Environmental Protection Agency — This EnviroAtlas dataset presents environmental benefits of the urban forest in 1 block group in Woodbine, Iowa. Carbon attributes, temperature reduction, pollution...

TIDALLY ENHANCED STELLAR WIND: A WAY TO MAKE THE SYMBIOTIC CHANNEL TO TYPE Ia SUPERNOVA VIABLE

International Nuclear Information System (INIS)

Chen, X.; Han, Z.; Tout, C. A.

2011-01-01

In the symbiotic (or WD+RG) channel of the single-degenerate scenario for type Ia supernovae (SNe Ia), the explosions occur a relatively long time after star formation. The birthrate from this channel would be too low to account for all observed SNe Ia were it not for some mechanism to enhance the rate of accretion on to the white dwarf. A tidally enhanced stellar wind, of the type which has been postulated to explain many phenomena related to giant star evolution in binary systems, can do this. Compared to mass stripping, this model extends the space of SNe Ia progenitors to longer orbital periods and hence increases the birthrate to about 0.0069 yr -1 for the symbiotic channel. Two symbiotic stars, T CrB and RS Oph, considered to be the most likely progenitors of SNe Ia through the symbiotic channel, are well inside the period-companion mass space predicted by our models.

Contribution of presynaptic HCN channels to excitatory inputs of spinal substantia gelatinosa neurons.

Science.gov (United States)

Peng, S-C; Wu, J; Zhang, D-Y; Jiang, C-Y; Xie, C-N; Liu, T

2017-09-01

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are pathological pain-associated voltage-gated ion channels. They are widely expressed in central nervous system including spinal lamina II (also named the substantia gelatinosa, SG). Here, we examined the distribution of HCN channels in glutamatergic synaptic terminals as well as their role in the modulation of synaptic transmission in SG neurons from SD rats and glutamic acid decarboxylase-67 (GAD67)-GFP mice. We found that the expression of the HCN channel isoforms was varied in SG. The HCN4 isoform showed the highest level of co-localization with VGLUT2 (23±3%). In 53% (n=21/40 neurons) of the SG neurons examined in SD rats, application of HCN channel blocker, ZD7288 (10μM), decreased the frequency of spontaneous (s) and miniature (m) excitatory postsynaptic currents (EPSCs) by 37±4% and 33±4%, respectively. Consistently, forskolin (FSK) (an activator of adenylate cyclase) significantly increased the frequency of mEPSCs by 225±34%, which could be partially inhibited by ZD7288. Interestingly, the effects of ZD7288 and FSK on sEPSC frequency were replicated in non-GFP-expressing neurons, but not in GFP-expressing GABAergic SG neurons, in GAD67-GFP transgenic C57/BL6 mice. In summary, our results represent a previously unknown cellular mechanism by which presynaptic HCN channels, especially HCN4, regulate the glutamate release from presynaptic terminals that target excitatory, but not inhibitory SG interneurons. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

75 FR 47059 - Notice To Rescind Notice of Intent To Prepare an Environmental Impact Statement: Warren County, IA

Science.gov (United States)

2010-08-04

... Prepare an Environmental Impact Statement: Warren County, IA AGENCY: Federal Highway Administration (FHWA... Realty Manager, FHWA Iowa Division Office, 105 Sixth Street, Ames, IA 50010, Phone 515-233-7302; or James... Lincoln Way, Ames, IA 50010, Phone 515-239-1798. SUPPLEMENTARY INFORMATION: Electronic Access An...

Zwischenberichterstattung nach Börsenrecht, DRS, IAS und US-GAAP

OpenAIRE

Alvarez von Zerboni di Sposetti, Manuel

2003-01-01

Zwischenberichterstattung nach Börsenrecht, DRS, IAS und US-GAAP / von Manuel Alvarez und Stefan Wotschofsky. - 2., neubearb. und erw. Aufl. - Berlin : Erich Schmidt, 2003. - XX, 219 S. [1. Aufl. 2000

Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia.

Science.gov (United States)

Smith, Clyde A; Toth, Marta; Bhattacharya, Monolekha; Frase, Hilary; Vakulenko, Sergei B

2014-06-01

The bifunctional acetyltransferase(6')-Ie-phosphotransferase(2'')-Ia [AAC(6')-Ie-APH(2'')-Ia] is the most important aminoglycoside-resistance enzyme in Gram-positive bacteria, conferring resistance to almost all known aminoglycoside antibiotics in clinical use. Owing to its importance, this enzyme has been the focus of intensive research since its isolation in the mid-1980s but, despite much effort, structural details of AAC(6')-Ie-APH(2'')-Ia have remained elusive. The structure of the Mg2GDP complex of the APH(2'')-Ia domain of the bifunctional enzyme has now been determined at 2.3 Å resolution. The structure of APH(2'')-Ia is reminiscent of the structures of other aminoglycoside phosphotransferases, having a two-domain architecture with the nucleotide-binding site located at the junction of the two domains. Unlike the previously characterized APH(2'')-IIa and APH(2'')-IVa enzymes, which are capable of utilizing both ATP and GTP as the phosphate donors, APH(2'')-Ia uses GTP exclusively in the phosphorylation of the aminoglycoside antibiotics, and in this regard closely resembles the GTP-dependent APH(2'')-IIIa enzyme. In APH(2'')-Ia this GTP selectivity is governed by the presence of a `gatekeeper' residue, Tyr100, the side chain of which projects into the active site and effectively blocks access to the adenine-binding template. Mutation of this tyrosine residue to a less bulky phenylalanine provides better access for ATP to the NTP-binding template and converts APH(2'')-Ia into a dual-specificity enzyme.

Studies on Pidotimod Enantiomers With Chiralpak-IA: Crystal Structure, Thermodynamic Parameters and Molecular Docking.

Science.gov (United States)

Dou, Xiaorui; Su, Xin; Wang, Yue; Chen, Yadong; Shen, Weiyang

2015-11-01

Pidotimod, a synthetic dipeptide, has two chiral centers with biological and immunological activity. Its enantiomers were characterized by x-ray crystallographic analysis. A chiral stationary phase (CSP) Chiralpak-IA based on amylose derivatized with tris-(3, 5-dimethylphenyl carbamate) was used to separate pidotimod enantiomers. The mobile phase was prepared in a ratio of 35:65:0.2 of methyl-tert-butyl-ether and acetonitrile trifluoroaceticacid. In addition, thermodynamics and molecular docking methods were used to explain the enantioseparation mechanism by Chiralpak-IA. Thermodynamic studies were carried out from 10 to 45 °C. In general, both retention and enantioselectivity decreased as the temperature increased. Thermodynamic parameters indicate that the interaction force between the pidotimod enantiomer (4S, 2'R) and IA CSP is stronger and their complex model is more stable. According to GOLD molecular docking simulation, Van der Waals force is the leading cause of pidotimod enantiomers separation by IA CSP. © 2015 Wiley Periodicals, Inc.

THE CARNEGIE SUPERNOVA PROJECT: SECOND PHOTOMETRY DATA RELEASE OF LOW-REDSHIFT TYPE Ia SUPERNOVAE

International Nuclear Information System (INIS)

Stritzinger, Maximilian D.; Phillips, M. M.; Campillay, Abdo; Morrell, Nidia; Krzeminski, Wojtek; Roth, Miguel; Boldt, Luis N.; Burns, Chris; Freedman, Wendy L.; Madore, Barry F.; Persson, Sven E.; Contreras, Carlos; Gonzalez, Sergio; Folatelli, Gaston; Salgado, Francisco; DePoy, D. L.; Marshall, J. L.; Rheault, Jean-Philippe; Suntzeff, Nicholas B.; Hamuy, Mario

2011-01-01

The Carnegie Supernova Project (CSP) was a five-year observational survey conducted at Las Campanas Observatory that obtained, among other things, high-quality light curves of ∼100 low-redshift Type Ia supernovae (SNe Ia). Presented here is the second data release of nearby SN Ia photometry consisting of 50 objects, with a subset of 45 having near-infrared follow-up observations. Thirty-three objects have optical pre-maximum coverage with a subset of 15 beginning at least five days before maximum light. In the near-infrared, 27 objects have coverage beginning before the epoch of B-band maximum, with a subset of 13 beginning at least five days before maximum. In addition, we present results of a photometric calibration program to measure the CSP optical (uBgVri) bandpasses with an accuracy of ∼1%. Finally, we report the discovery of a second SN Ia, SN 2006ot, similar in its characteristics to the peculiar SN 2006bt.

Measurements of the Rate of Type Ia Supernovae at Redshift z < ~0.3 from the SDSS-II Supernova Survey

Energy Technology Data Exchange (ETDEWEB)

Dilday, Benjamin; /Rutgers U., Piscataway /Chicago U. /KICP, Chicago; Smith, Mathew; /Cape Town U., Dept. Math. /Portsmouth U.; Bassett, Bruce; /Cape Town U., Dept. Math. /South African Astron. Observ.; Becker, Andrew; /Washington U., Seattle, Astron. Dept.; Bender, Ralf; /Munich, Tech. U. /Munich U. Observ.; Castander, Francisco; /Barcelona, IEEC; Cinabro, David; /Wayne State U.; Filippenko, Alexei V.; /UC, Berkeley; Frieman, Joshua A.; /Chicago U. /Fermilab; Galbany, Lluis; /Barcelona, IFAE; Garnavich, Peter M.; /Notre Dame U. /Stockholm U., OKC /Stockholm U.

2010-01-01

We present a measurement of the volumetric Type Ia supernova (SN Ia) rate based on data from the Sloan Digital Sky Survey II (SDSS-II) Supernova Survey. The adopted sample of supernovae (SNe) includes 516 SNe Ia at redshift z {approx}< 0.3, of which 270 (52%) are spectroscopically identified as SNe Ia. The remaining 246 SNe Ia were identified through their light curves; 113 of these objects have spectroscopic redshifts from spectra of their host galaxy, and 133 have photometric redshifts estimated from the SN light curves. Based on consideration of 87 spectroscopically confirmed non-Ia SNe discovered by the SDSS-II SN Survey, we estimate that 2.04{sub -0.95}{sup +1.61}% of the photometric SNe Ia may be misidentified. The sample of SNe Ia used in this measurement represents an order of magnitude increase in the statistics for SN Ia rate measurements in the redshift range covered by the SDSS-II Supernova Survey. If we assume a SN Ia rate that is constant at low redshift (z < 0.15), then the SN observations can be used to infer a value of the SN rate of r{sub V} = (2.69{sub -0.30-0.01}{sup +0.34+0.21}) x 10{sup -5} SNe yr{sup -1} Mpc{sup -3} (H{sub 0}/(70 km s{sup -1} Mpc{sup -1})){sup 3} at a mean redshift of {approx} 0.12, based on 79 SNe Ia of which 72 are spectroscopically confirmed. However, the large sample of SNe Ia included in this study allows us to place constraints on the redshift dependence of the SN Ia rate based on the SDSS-II Supernova Survey data alone. Fitting a power-law model of the SN rate evolution, r{sub V} (z) = A{sub p} x ((1+z)/(1+z{sub 0})){sup {nu}}, over the redshift range 0.0 < z < 0.3 with z{sub 0} = 0.21, results in A{sub p} = (3.43{sub -0.15}{sup +0.15}) x 10{sup -5} SNe yr{sup -1} Mpc{sup -3} (H{sub 0}/(70 km s{sup -1} Mpc{sup -1})){sup 3} and {nu} = 2.04{sub -0.89}{sup +0.90}.

EnviroAtlas - Woodbine, IA - Land Cover by Block Group

Data.gov (United States)

U.S. Environmental Protection Agency — This EnviroAtlas dataset describes the percentage of each block group that is classified as impervious, forest, and green space. Forest is combination of trees and...

THE ABSOLUTE MAGNITUDES OF TYPE Ia SUPERNOVAE IN THE ULTRAVIOLET

International Nuclear Information System (INIS)

Brown, Peter J.; Roming, Peter W. A.; Ciardullo, Robin; Gronwall, Caryl; Hoversten, Erik A.; Pritchard, Tyler; Milne, Peter; Bufano, Filomena; Mazzali, Paolo; Elias-Rosa, Nancy; Filippenko, Alexei V.; Li Weidong; Foley, Ryan J.; Hicken, Malcolm; Kirshner, Robert P.; Gehrels, Neil; Holland, Stephen T.; Immler, Stefan; Phillips, Mark M.; Still, Martin

2010-01-01

We examine the absolute magnitudes and light-curve shapes of 14 nearby (redshift z = 0.004-0.027) Type Ia supernovae (SNe Ia) observed in the ultraviolet (UV) with the Swift Ultraviolet/Optical Telescope. Colors and absolute magnitudes are calculated using both a standard Milky Way extinction law and one for the Large Magellanic Cloud that has been modified by circumstellar scattering. We find very different behavior in the near-UV filters (uvw1 rc covering ∼2600-3300 A after removing optical light, and u ∼ 3000-4000 A) compared to a mid-UV filter (uvm2 ∼2000-2400 A). The uvw1 rc - b colors show a scatter of ∼0.3 mag while uvm2-b scatters by nearly 0.9 mag. Similarly, while the scatter in colors between neighboring filters is small in the optical and somewhat larger in the near-UV, the large scatter in the uvm2 - uvw1 colors implies significantly larger spectral variability below 2600 A. We find that in the near-UV the absolute magnitudes at peak brightness of normal SNe Ia in our sample are correlated with the optical decay rate with a scatter of 0.4 mag, comparable to that found for the optical in our sample. However, in the mid-UV the scatter is larger, ∼1 mag, possibly indicating differences in metallicity. We find no strong correlation between either the UV light-curve shapes or the UV colors and the UV absolute magnitudes. With larger samples, the UV luminosity might be useful as an additional constraint to help determine distance, extinction, and metallicity in order to improve the utility of SNe Ia as standardized candles.

Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1

DEFF Research Database (Denmark)

Jensen, Anders Asbjørn; Erichsen, Mette Navy; Nielsen, Christina Wøhlk

2009-01-01

The discovery of the first class of subtype-selective inhibitors of the human excitatory amino acid transporter subtype 1 (EAAT1) and its rat orthologue GLAST is reported. An opening structure-activity relationship of 25 analogues is presented that addresses the influence of substitutions at the 4......- and 7-positions of the parental skeleton 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile. The most potent analogue 1o displays high nanomolar inhibitory activity at EAAT1 and a >400-fold selectivity over EAAT2 and EAAT3, making it a highly valuable pharmacological tool....

The VO-Dance web application at the IA2 data center

Science.gov (United States)

Molinaro, Marco; Knapic, Cristina; Smareglia, Riccardo

2012-09-01

Italian center for Astronomical Archives (IA2, http://ia2.oats.inaf.it) is a national infrastructure project of the Italian National Institute for Astrophysics (Istituto Nazionale di AstroFisica, INAF) that provides services for the astronomical community. Besides data hosting for the Large Binocular Telescope (LBT) Corporation, the Galileo National Telescope (Telescopio Nazionale Galileo, TNG) Consortium and other telescopes and instruments, IA2 offers proprietary and public data access through user portals (both developed and mirrored) and deploys resources complying the Virtual Observatory (VO) standards. Archiving systems and web interfaces are developed to be extremely flexible about adding new instruments from other telescopes. VO resources publishing, along with data access portals, implements the International Virtual Observatory Alliance (IVOA) protocols providing astronomers with new ways of analyzing data. Given the large variety of data flavours and IVOA standards, the need for tools to easily accomplish data ingestion and data publishing arises. This paper describes the VO-Dance tool, that IA2 started developing to address VO resources publishing in a dynamical way from already existent database tables or views. The tool consists in a Java web application, potentially DBMS and platform independent, that stores internally the services' metadata and information, exposes restful endpoints to accept VO queries for these services and dynamically translates calls to these endpoints to SQL queries coherent with the published table or view. In response to the call VO-Dance translates back the database answer in a VO compliant way.

The cooling time of white dwarfs produced from type Ia supernovae

International Nuclear Information System (INIS)

Meng Xiangcun; Yang Wuming; Li Zhongmu

2010-01-01

Type Ia supernovae (SNe Ia) play a key role in measuring cosmological parameters, in which the Phillips relation is adopted. However, the origin of the relation is still unclear. Several parameters are suggested, e.g. the relative content of carbon to oxygen (C/O) and the central density of the white dwarf (WD) at ignition. These parameters are mainly determined by the WD's initial mass and its cooling time, respectively. Using the progenitor model developed by Meng and Yang, we present the distributions of the initial WD mass and the cooling time. We do not find any correlation between these parameters. However, we notice that as the range of the WD's mass decreases, its average value increases with the cooling time. These results could provide a constraint when simulating the SN Ia explosion, i.e. the WDs with a high C/O ratio usually have a lower central density at ignition, while those having the highest central density at ignition generally have a lower C/O ratio. The cooling time is mainly determined by the evolutionary age of secondaries, and the scatter of the cooling time decreases with the evolutionary age. Our results may indicate that WDs with a long cooling time have more uniform properties than those with a short cooling time, which may be helpful to explain why SNe Ia in elliptical galaxies have a more uniform maximum luminosity than those in spiral galaxies. (research papers)

Radiologic Predictors for Clinical Stage IA Lung Adenocarcinoma with Ground Glass Components: A Multi-Center Study of Long-Term Outcomes.

Directory of Open Access Journals (Sweden)

Zhao Li

Full Text Available This study was to define preoperative predictors from radiologic findings for the pathologic risk groups based on long-term surgical outcomes, in the aim to help guide individualized patient management.We retrospectively reviewed 321 consecutive patients with clinical stage IA lung adenocarcinoma with ground glass component on computed tomography (CT scanning. Pathologic diagnosis for resection specimens was based on the 2011 IASLC/ATS/ERS classification of lung adenocarcinoma. Patients were classified into different pathologic risk grading groups based on their lymph node status, local regional recurrence and overall survival. Radiologic characteristics of the pulmonary nodules were re-evaluated by reconstructed three-dimension CT (3D-CT. Univariate and multivariate analysis identifies independent radiologic predictors from tumor diameter, total volume (TV, average CT value (AVG, and solid-to-tumor (S/T ratio. Receiver operating characteristic curves (ROC studies were carried out to determine the cutoff value(s for the predictor(s. Univariate cox regression model was used to determine the clinical significance of the above findings.A total of 321 patients with clinical stage IA lung adenocarcinoma with ground glass components were included in our study. Patients were classified into two pathologic low- and high- risk groups based on their distinguished surgical outcomes. A total of 134 patients fell into the low-risk group. Univariate and multivariate analyses identified AVG (HR: 32.210, 95% CI: 3.020-79.689, P<0.001 and S/T ratio (HR: 12.212, 95% CI: 5.441-27.408, P<0.001 as independent predictors for pathologic risk grading. ROC curves studies suggested the optimal cut-off values for AVG and S/T ratio were-198 (area under the curve [AUC] 0.921, 2.9 (AUC 0.996 and 54% (AUC 0.907, respectively. The tumor diameter and TV were excluded for the low AUCs (0.778 and 0.767. Both the cutoff values of AVG and S/T ratio were correlated with pathologic

The extent and intensity of the urban heat island in Iași city, Romania

Science.gov (United States)

Sfîcă, Lucian; Ichim, Pavel; Apostol, Liviu; Ursu, Adrian

2017-10-01

The study underlines the characteristics of the urban heat island of Iași (Iași's UHI) on the basis of 3 years of air temperature measurements obtained by fixed-point observations. We focus on the identification of UHI development and intensity as it is expressed by the temperature differences between the city centre and the rural surroundings. Annual, seasonal and daily characteristics of Iaşi's UHI are investigated at the level of the classical weather observation. In brief, an intensity of 0.8 °C of UHI and a spatial extension which corresponds to the densely built area of the city were delineated. The Iaşi UHI is stronger during summer calm nights—when the inner city is warmer with 2.5-3 °C than the surroundings—and is weaker during windy spring days. The specific features of Iași's UHI bear a profound connection to the specificity of the urban structure, the high atmospheric stability in the region and the local topography. Also, the effects of Iași's UHI upon some environmental aspects are presented as study cases. For instance, under the direct influence of UHI, we have observed that in the city centre, the apricot tree blossoms earlier (with up to 4 days) and the depth of the snow cover is significantly lower (with up to 10 cm for a rural snow depth of 30 cm) than in the surrounding areas.

e73.pdf.pdf | 92 | OnlineResources | jgenet | www.ias.ac.in | http ...

Indian Academy of Sciences (India)

Home; public; Volumes; jgen; 092; online; http; www.ias.ac.in; jgenet; OnlineResources; 92; e73.pdf.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 ...

Hierarchical Models for Type Ia Supernova Light Curves in the Optical and Near Infrared

Science.gov (United States)

Mandel, Kaisey; Narayan, G.; Kirshner, R. P.

2011-01-01

I have constructed a comprehensive statistical model for Type Ia supernova optical and near infrared light curves. Since the near infrared light curves are excellent standard candles and are less sensitive to dust extinction and reddening, the combination of near infrared and optical data better constrains the host galaxy extinction and improves the precision of distance predictions to SN Ia. A hierarchical probabilistic model coherently accounts for multiple random and uncertain effects, including photometric error, intrinsic supernova light curve variations and correlations across phase and wavelength, dust extinction and reddening, peculiar velocity dispersion and distances. An improved BayeSN MCMC code is implemented for computing probabilistic inferences for individual supernovae and the SN Ia and host galaxy dust populations. I use this hierarchical model to analyze nearby Type Ia supernovae with optical and near infared data from the PAIRITEL, CfA3, and CSP samples and the literature. Using cross-validation to test the robustness of the model predictions, I find that the rms Hubble diagram scatter of predicted distance moduli is 0.11 mag for SN with optical and near infrared data versus 0.15 mag for SN with only optical data. Accounting for the dispersion expected from random peculiar velocities, the rms intrinsic prediction error is 0.08-0.10 mag for SN with both optical and near infrared light curves. I discuss results for the inferred intrinsic correlation structures of the optical-NIR SN Ia light curves and the host galaxy dust distribution captured by the hierarchical model. The continued observation and analysis of Type Ia SN in the optical and near infrared is important for improving their utility as precise and accurate cosmological distance indicators.

Progenitors of type Ia supernovae in elliptical galaxies

International Nuclear Information System (INIS)

Gilfanov, M.; Bogdan, A.

2011-01-01

Although there is a nearly universal agreement that type Ia supernovae are associated with the thermonuclear disruption of a CO white dwarf, the exact nature of their progenitors is still unknown. The single degenerate scenario envisages a white dwarf accreting matter from a non-degenerate companion in a binary system. Nuclear energy of the accreted matter is released in the form of electromagnetic radiation or gives rise to numerous classical nova explosions prior to the supernova event. We show that combined X-ray output of supernova progenitors and statistics of classical novae predicted in the single degenerate scenario are inconsistent with X-ray and optical observations of nearby early type galaxies and galaxy bulges. White dwarfs accreting from a donor star in a binary system and detonating at the Chandrasekhar mass limit can account for no more than ∼5% of type Ia supernovae observed in old stellar populations.

Survival after Stage IA Endometrial Cancer; Can follow-up be altered?

DEFF Research Database (Denmark)

Lajer, Henrik; Elnegaard, Sandra; Christensen, René D

2012-01-01

IA (1988 classification) endometrial cancer patients prospectively included between 1986 and 1999. All patients had total abdominal hysterectomy and bilateral salpingo-oophorectomy without adjuvant therapy. Methods. The patient and the disease characteristics were drawn from the DEMCA database....... Of these recurrences, 15 of 23 (65%) were vaginal. Death from recurrence was observed in nine of 23 (39%) patients, and five of these nine had vaginal recurrences. Conclusions. Women with FIGO stage IA endometrial cancer have a very high disease-specific five year survival. Survival was related to histopathology...

Human platelet glycoprotein Ia. One component is only expressed on the surface of activated platelets and may be a granule constituent

International Nuclear Information System (INIS)

Bienz, D.; Clemetson, K.J.

1989-01-01

Glycoprotein Ia (GP Ia) is a relatively minor component of human blood platelets thought to be a receptor involved in collagen-induced platelet activation. However, some difficulties exist with the definition of this glycoprotein. The expression of GP Ia on resting (prostacyclin analogue-treated) and thrombin-activated platelets was compared by surface labeling with 125 I-lactoperoxidase. Intact platelets or platelets solubilized in sodium dodecyl sulfate were labeled with periodate/[ 3 H]NaBH 4 . Analysis on two-dimensional isoelectric focusing/sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels showed that GP Ia is very poorly labeled in resting platelets. After activation a new spot (GP Ia*) appears with the same relative molecular mass as GP Ia under reducing conditions. GP Ia and Ia* can be clearly separated by two-dimensional nonreduced/reduced gel electrophoresis. Therefore, two glycoproteins which have been termed GP Ia exist in platelets with similar molecular weight and pI under reducing conditions. One of these (GP Ia*) is only surface-labeled when platelets are activated, indicating that it is only exposed on the surface of activated platelets. Supernatant from activated platelets contains this glycoprotein as well as other granule components. This glycoprotein is missing in platelets from two patients with collagen-response defects

THE TYPE Ia SUPERNOVA RATE IN RADIO AND INFRARED GALAXIES FROM THE CANADA-FRANCE-HAWAII TELESCOPE SUPERNOVA LEGACY SURVEY

International Nuclear Information System (INIS)

Graham, M. L.; Pritchet, C. J.; Balam, D.; Fabbro, S.; Sullivan, M.; Hook, I. M.; Howell, D. A.; Gwyn, S. D. J.; Astier, P.; Balland, C.; Guy, J.; Hardin, D.; Pain, R.; Regnault, N.; Basa, S.; Carlberg, R. G.; Perrett, K.; Conley, A.; Fouchez, D.; Rich, J.

2010-01-01

We have combined the large SN Ia database of the Canada-France-Hawaii Telescope Supernova Legacy Survey and catalogs of galaxies with photometric redshifts, Very Large Array 1.4 GHz radio sources, and Spitzer infrared sources. We present eight SNe Ia in early-type host galaxies which have counterparts in the radio and infrared source catalogs. We find the SN Ia rate in subsets of radio and infrared early-type galaxies is ∼1-5 times the rate in all early-type galaxies, and that any enhancement is always ∼<2σ. Rates in these subsets are consistent with predictions of the two-component 'A+B' SN Ia rate model. Since infrared properties of radio SN Ia hosts indicate dust-obscured star formation, we incorporate infrared star formation rates into the 'A+B' model. We also show the properties of SNe Ia in radio and infrared galaxies suggest the hosts contain dust and support a continuum of delay time distributions (DTDs) for SNe Ia, although other DTDs cannot be ruled out based on our data.

LUMINOSITY FUNCTIONS OF TYPE Ia SUPERNOVAE AND THEIR HOST GALAXIES FROM THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Yasuda, Naoki; Fukugita, Masataka

2010-01-01

The sample of 137 low-redshift type Ia supernovae (SNe Ia) with 0.05 ≤ z ≤ 0.3 obtained from the Sloan Digital Sky Survey (SDSS)-II supernova survey for the southern equatorial stripe of 300 deg 2 is used to derive the luminosity functions (LFs) of SNe Ia and of their host galaxies in the g, r, i passbands. We show that the LF of SNe Ia host galaxies matches well with that of galaxies in the general field, suggesting that the occurrence of SNe Ia does not favor a particular type of galaxy but is predominantly proportional to the luminosity of galaxies. The evidence is weak that the SNe rate varies with the color of host galaxies. The only evidence that points to possible correlation between the SN rate and star formation activity is that the SN rate in late-type galaxies is higher than that in early-type galaxies by 31% ± 35%. In our low-redshift sample, the component of type Ia SN rate that is proportional to star formation activity is not evident in the integrated SN rate, while our observation is compatible with the current two-component models. The sample contains eight SNe Ia whose host galaxies were not identified, but it is shown that their occurrence is consistent with them occurring in low-luminous galaxies beyond the survey. The LF of SNe Ia is approximately Gaussian with the full width at half-maximum being a factor of σ = 0.24 mag or 1.67 in luminosity. The Gaussian distribution becomes tighter if the ratio of extinction to reddening, R V , is lower than the characteristic value for the Milky Way and if luminosity is corrected for the light-curve shape. The average color excess is ∼0.07 mag, which is significantly smaller than reddening expected for field galaxies. This color excess does not vary with the distance of the SNe from the center of the host galaxy to 15 kpc. This suggests that the major part of the color excess appears to be either intrinsic or reddening that arises in the immediate environment of SNe, rather than interstellar

PHOTOMETRIC TYPE Ia SUPERNOVA CANDIDATES FROM THE THREE-YEAR SDSS-II SN SURVEY DATA

International Nuclear Information System (INIS)

Sako, Masao; Connolly, Brian; Gladney, Larry; Bassett, Bruce; Dilday, Benjamin; Cambell, Heather; Lampeitl, Hubert; Nichol, Robert C.; Frieman, Joshua A.; Kessler, Richard; Marriner, John; Miquel, Ramon; Schneider, Donald P.; Smith, Mathew; Sollerman, Jesper

2011-01-01

We analyze the three-year Sloan Digital Sky Survey II (SDSS-II) Supernova (SN) Survey data and identify a sample of 1070 photometric Type Ia supernova (SN Ia) candidates based on their multiband light curve data. This sample consists of SN candidates with no spectroscopic confirmation, with a subset of 210 candidates having spectroscopic redshifts of their host galaxies measured while the remaining 860 candidates are purely photometric in their identification. We describe a method for estimating the efficiency and purity of photometric SN Ia classification when spectroscopic confirmation of only a limited sample is available, and demonstrate that SN Ia candidates from SDSS-II can be identified photometrically with ∼91% efficiency and with a contamination of ∼6%. Although this is the largest uniform sample of SN candidates to date for studying photometric identification, we find that a larger spectroscopic sample of contaminating sources is required to obtain a better characterization of the background events. A Hubble diagram using SN candidates with no spectroscopic confirmation, but with host galaxy spectroscopic redshifts, yields a distance modulus dispersion that is only ∼20%-40% larger than that of the spectroscopically confirmed SN Ia sample alone with no significant bias. A Hubble diagram with purely photometric classification and redshift-distance measurements, however, exhibits biases that require further investigation for precision cosmology.

Photometric type Ia supernova candidates from the three-year SDSS-II SN survey data

Energy Technology Data Exchange (ETDEWEB)

Sako, Masao; /Pennsylvania U.; Bassett, Bruce; /South African Astron. Observ. /Cape Town U., Dept. Math.; Connolly, Brian; /Pennsylvania U.; Dilday, Benjamin; /Las Cumbres Observ. /UC, Santa Barbara /Rutgers U., Piscataway; Cambell, Heather; /Portsmouth U., ICG; Frieman, Joshua A.; /Chicago U. /Chicago U., KICP /Fermilab; Gladney, Larry; /Pennsylvania U.; Kessler, Richard; /Chicago U. /Chicago U., KICP; Lampeitl, Hubert; /Portsmouth U., ICG; Marriner, John; /Fermilab; Miquel, Ramon; /Barcelona, IFAE /ICREA, Barcelona /Portsmouth U., ICG

2011-07-01

We analyze the three-year Sloan Digital Sky Survey II (SDSS-II) Supernova (SN) Survey data and identify a sample of 1070 photometric Type Ia supernova (SN Ia) candidates based on their multiband light curve data. This sample consists of SN candidates with no spectroscopic confirmation, with a subset of 210 candidates having spectroscopic redshifts of their host galaxies measured while the remaining 860 candidates are purely photometric in their identification. We describe a method for estimating the efficiency and purity of photometric SN Ia classification when spectroscopic confirmation of only a limited sample is available, and demonstrate that SN Ia candidates from SDSS-II can be identified photometrically with {approx}91% efficiency and with a contamination of {approx}6%. Although this is the largest uniform sample of SN candidates to date for studying photometric identification, we find that a larger spectroscopic sample of contaminating sources is required to obtain a better characterization of the background events. A Hubble diagram using SN candidates with no spectroscopic confirmation, but with host galaxy spectroscopic redshifts, yields a distance modulus dispersion that is only {approx}20%-40% larger than that of the spectroscopically confirmed SN Ia sample alone with no significant bias. A Hubble diagram with purely photometric classification and redshift-distance measurements, however, exhibits biases that require further investigation for precision cosmology.

The Influence of Cyst Emptying, Lymph Node Resection and Chemotherapy on Survival in Stage IA and IC1 Epithelial Ovarian Cancer

DEFF Research Database (Denmark)

Rosendahl, Mikkel; Mosgaard, Berit Jul; Høgdall, Claus

2016-01-01

AIM: To determine if survival in stage I ovarian cancer is influenced by cyst emptying, lymph node resection and chemotherapy. PATIENTS AND METHODS: A survival analysis of 607 patients with ovarian cancer in stage IA, IA with cyst emptying (IAempty) and IC1 was performed. RESULTS......: There was no difference in five-year survival between IA (87%) and IC1 (87%) (p=0.899), between IA and IAempty (86%) (p=0.500) nor between IA+IAempty (87%) and IC1 without IAempty (84%) (p=0.527). Five-year survival rate (5YSR) was significantly higher after lymph node resection in stage IA (94% vs. 85%; p=0.01) and IA......+IC1 (93% vs. 85%; p=0.004). In multivariate analysis, lymph node resection improved prognosis significantly for all sub-stages, whereas stage and chemotherapy did not affect survival. CONCLUSION: In stage IA ovarian cancer, controlled cyst emptying without spill does not worsen prognosis. Lymph node...

Effects of Group Counseling Programs, Cognitive Behavioral Therapy, and Sports Intervention on Internet Addiction in East Asia: A Systematic Review and Meta-Analysis.

Science.gov (United States)

Liu, Jun; Nie, Jing; Wang, Yafeng

2017-11-28

To evaluate the effects of group counseling programs, cognitive behavioral therapy (CBT), and sports intervention on Internet addiction (IA), a systematic search in ten databases was performed to identify eligible studies without language restrictions up to January 2017. A meta-analysis and trial sequential analysis (TSA) was performed, respectively. A total of 58 randomized controlled trials (RCTs), which included 2871 participants, were incorporated into our meta-analysis. The results showed that group counseling programs, CBT, and sports intervention could significantly reduce IA levels (group counseling program: standardized mean difference (SMD), -1.37; 95% confidence interval (CI), -1.89 to -0.85; CBT: SMD, -1.88; 95% CI, -2.53 to -1.23; sports intervention: SMD, -1.70; 95% CI, -2.14 to -1.26). For group counseling programs, this treatment was more effective in four dimensions of IA, including time management, interpersonal and health issues, tolerance, and compulsive Internet use. For CBT, this treatment yielded a positive change in depression, anxiousness, aggressiveness, somatization, social insecurity, phobic anxiety, paranoid ideation, and psychoticism. For sports intervention, the significant effects were also observed in all dimensions of the IA scale. Each of group counseling programs, cognitive behavioral therapy, and sports intervention had a significant effect on IA and psychopathological symptoms. Sports intervention could improve withdrawal symptoms especially.

Light and Color Curve Properties of Type Ia Supernovae: Theory Versus Observations

Energy Technology Data Exchange (ETDEWEB)

Hoeflich, P.; Hsiao, E. Y. [Department of Physics, Florida State University, Tallahassee, FL 32306 (United States); Ashall, C. [Astrophysics Research Institute, Liverpool John Moore University, 146 Brownlow Hill, Liverpool L3 5RF (United Kingdom); Burns, C. R. [Observatories of the Carnegie Institution for Science, 813 Santa Barbara St., Pasadena, CA 91101 (United States); Diamond, T. R. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Phillips, M. M. [Carnegie Observatories, Las Campanas Observatory, Casilla 601 La Serena (Chile); Sand, D. [Physics and Astronomy Department, Texas Tech University, Box 41051, Lubbock, TX 79409-1051 (United States); Stritzinger, M. D. [Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000, Aarhus (Denmark); Suntzeff, N.; Krisciunas, K.; Wang, L. [The G.P. and C. Woods Mitchell Institute for Fundamental Physics and Astronomy, Texas A and M University, Department of Physics and Astronomy, 4242 TAMU, College Station, TX 77843 (United States); Contreras, C.; Morrell, N., E-mail: phoeflich77@gmail.com [Departamento de Física, Universidad Técnica Federico Santa Maria, Ava España 1680, Casilla 110-V, Valparaiso (Chile)

2017-09-01

We study the optical light curve (LC) relations of Type Ia supernovae (SNe Ia) for their use in cosmology using high-quality photometry published by the Carnegie Supernova Project (CSP-I). We revisit the classical luminosity decline rate (Δ m {sub 15}) relation and the Lira relation, as well as investigate the time evolution of the ( B − V ) color and B ( B − V ), which serves as the basis of the color–stretch relation and Color–MAgnitude Intercept Calibrations (CMAGIC). Our analysis is based on explosion and radiation transport simulations for spherically symmetric delayed-detonation models (DDT) producing normal-bright and subluminous SNe Ia. Empirical LC relations can be understood as having the same physical underpinnings, i.e., opacities, ionization balances in the photosphere, and radioactive energy deposition changing with time from below to above the photosphere. Some three to four weeks past maximum, the photosphere recedes to {sup 56}Ni-rich layers of similar density structure, leading to a similar color evolution. An important secondary parameter is the central density ρ {sub c} of the WD because at higher densities, more electron-capture elements are produced at the expense of {sup 56}Ni production. This results in a Δ m {sub 15} spread of 0.1 mag in normal-bright and 0.7 mag in subluminous SNe Ia and ≈0.2 mag in the Lira relation. We show why color–magnitude diagrams emphasize the transition between physical regimes and enable the construction of templates that depend mostly on Δ m {sub 15} with little dispersion in both the CSP-I sample and our DDT models. This allows intrinsic SN Ia variations to be separated from the interstellar reddening characterized by E ( B − V ) and R {sub B}. Invoking different scenarios causes a wide spread in empirical relations, which may suggest one dominant scenario.

Light and Color Curve Properties of Type Ia Supernovae: Theory Versus Observations

International Nuclear Information System (INIS)

Hoeflich, P.; Hsiao, E. Y.; Ashall, C.; Burns, C. R.; Diamond, T. R.; Phillips, M. M.; Sand, D.; Stritzinger, M. D.; Suntzeff, N.; Krisciunas, K.; Wang, L.; Contreras, C.; Morrell, N.

2017-01-01

We study the optical light curve (LC) relations of Type Ia supernovae (SNe Ia) for their use in cosmology using high-quality photometry published by the Carnegie Supernova Project (CSP-I). We revisit the classical luminosity decline rate (Δ m 15 ) relation and the Lira relation, as well as investigate the time evolution of the ( B − V ) color and B ( B − V ), which serves as the basis of the color–stretch relation and Color–MAgnitude Intercept Calibrations (CMAGIC). Our analysis is based on explosion and radiation transport simulations for spherically symmetric delayed-detonation models (DDT) producing normal-bright and subluminous SNe Ia. Empirical LC relations can be understood as having the same physical underpinnings, i.e., opacities, ionization balances in the photosphere, and radioactive energy deposition changing with time from below to above the photosphere. Some three to four weeks past maximum, the photosphere recedes to 56 Ni-rich layers of similar density structure, leading to a similar color evolution. An important secondary parameter is the central density ρ c of the WD because at higher densities, more electron-capture elements are produced at the expense of 56 Ni production. This results in a Δ m 15 spread of 0.1 mag in normal-bright and 0.7 mag in subluminous SNe Ia and ≈0.2 mag in the Lira relation. We show why color–magnitude diagrams emphasize the transition between physical regimes and enable the construction of templates that depend mostly on Δ m 15 with little dispersion in both the CSP-I sample and our DDT models. This allows intrinsic SN Ia variations to be separated from the interstellar reddening characterized by E ( B − V ) and R B . Invoking different scenarios causes a wide spread in empirical relations, which may suggest one dominant scenario.

Dlouhodobý hmotný majetek dle českých účetních předpisů a IAS/IFRS

OpenAIRE

Karľa, Tomáš

2009-01-01

Purpose of this work is to describe tangible fixed assets in compliance with czech accounting regulations and International Accounting Standards (IAS/IFRS) and compare them, i. e. point out common principles and differences of czech accounting regulations and IAS (primarily IAS 16) in this matter. Intangible fixed assets (IAS 38) and specifity of agriculture (IAS 41) are not objects of this work.

Type-Ia Supernova Rates to Redshift 2.4 from Clash: The Cluster Lensing and Supernova Survey with Hubble

Science.gov (United States)

Graur, O.; Rodney, S. A.; Maoz, D.; Riess, A. G.; Jha, S. W.; Postman, M.; Dahlen, T.; Holoien, T. W.-S.; McCully, C.; Patel, B.;

Developmental changes in electrophysiological properties and a transition from electrical to chemical coupling between excitatory layer 4 neurons in the rat barrel cortex

Directory of Open Access Journals (Sweden)

Fliza eValiullina

2016-01-01

Full Text Available During development, sensory systems switch from an immature to an adult mode of function along with the emergence of the active cortical states. Here, we used patch-clamp recordings from neocortical slices in vitro to characterize the developmental changes in the basic electrophysiological properties of excitatory L4 neurons and their connectivity before and after the developmental switch, which occurs in the rat barrel cortex in vivo at postnatal day P8. Prior to the switch, L4 neurons had lower resting membrane potentials, higher input resistance, lower membrane capacity, as well as action potentials (APs with smaller amplitudes, longer durations and higher AP thresholds compared to the neurons after the switch. A sustained firing pattern also emerged around the switch. Dual patch-clamp recordings from L4 neurons revealed that recurrent connections between L4 excitatory cells do not exist before and develop rapidly across the switch. In contrast, electrical coupling between these neurons waned around the switch. We suggest that maturation of electrophysiological features, particularly acquisition of a sustained firing pattern, and a transition from the immature electrical to mature chemical synaptic coupling between excitatory L4 neurons, contributes to the developmental switch in the cortical mode of function.

ROS and trehalose regulate sclerotial development in Rhizoctonia solani AG-1 IA.

Science.gov (United States)

Wang, Chenjiaozi; Pi, Lei; Jiang, Shaofeng; Yang, Mei; Shu, Canwei; Zhou, Erxun

2018-05-01

Rhizoctonia solani AG-1 IA is the causal agent of rice sheath blight (RSB) and causes severe economic losses in rice-growing regions around the world. The sclerotia play an important role in the disease cycle of RSB. In this study, we report the effects of reactive oxygen species (ROS) and trehalose on the sclerotial development of R. solani AG-1 IA. Correlation was found between the level of ROS in R. solani AG-1 IA and sclerotial development. Moreover, we have shown the change of ROS-related enzymatic activities and oxidative burst occurs at the sclerotial initial stage. Six genes related to the ROS scavenging system were quantified in different sclerotial development stages by using quantitative RT-PCR technique, thereby confirming differential gene expression. Fluorescence microscopy analysis of ROS content in mycelia revealed that ROS were predominantly produced at the hyphal branches during the sclerotial initial stage. Furthermore, exogenous trehalose had a significant inhibitory effect on the activities of ROS-related enzymes and oxidative burst and led to a reduction in sclerotial dry weight. Taken together, the findings suggest that ROS has a promoting effect on the development of sclerotia, whereas trehalose serves as an inhibiting factor to sclerotial development in R. solani AG-1 IA. Copyright © 2018 British Mycological Society. Published by Elsevier Ltd. All rights reserved.

Intermittent auscultation (IA) of fetal heart rate in labour for fetal well-being.

Science.gov (United States)

Martis, Ruth; Emilia, Ova; Nurdiati, Detty S; Brown, Julie

2017-02-13

The goal of fetal monitoring in labour is the early detection of a hypoxic baby. There are a variety of tools and methods available for intermittent auscultation (IA) of the fetal heart rate (FHR). Low- and middle-income countries usually have only access to a Pinard/Laënnec or the use of a hand-held Doppler device. Currently, there is no robust evidence to guide clinical practice on the most effective IA tool to use, timing intervals and length of listening to the fetal heart for women during established labour. To evaluate the effectiveness of different tools for IA of the fetal heart rate during labour including frequency and duration of auscultation. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (19 September 2016), contacted experts and searched reference lists of retrieved articles. All published and unpublished randomised controlled trials (RCTs) or cluster-RCTs comparing different tools and methods used for intermittent fetal auscultation during labour for fetal and maternal well-being. Quasi-RCTs, and cross-over designs were not eligible for inclusion. All review authors independently assessed eligibility, extracted data and assessed risk of bias for each trial. Data were checked for accuracy. We included three studies (6241 women and 6241 babies), but only two studies are included in the meta-analyses (3242 women and 3242 babies). Both were judged as high risk for performance bias due to the inability to blind the participants and healthcare providers to the interventions. Evidence was graded as moderate to very low quality; the main reasons for downgrading were study design limitations and imprecision of effect estimates. Intermittent Electronic Fetal Monitoring (EFM) using Cardiotocography (CTG) with routine Pinard (one trial)There was no clear difference between groups in low Apgar scores at five minutes (reported as < six at five minutes after birth) (risk ratio (RR) 0.66, 95% confidence interval (CI) 0.24 to 1.83, 633

75 FR 65390 - Iowa Disaster Number IA-00024

Science.gov (United States)

2010-10-22

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12279 and 12280] Iowa Disaster Number IA-00024 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Iowa (FEMA--1930--DR), dated 08/14/ 2010...

75 FR 51506 - Iowa Disaster Number IA-00026

Science.gov (United States)

2010-08-20

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster Number IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1930-DR...

78 FR 53492 - Iowa Disaster Number IA-00053

Science.gov (United States)

2013-08-29

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13699 and 13700] Iowa Disaster Number IA-00053 AGENCY: U.S. Small Business Administration. Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 4135-DR...

75 FR 59750 - Iowa Disaster Number IA-00026

Science.gov (United States)

2010-09-28

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12258 and 12259] Iowa Disaster Number IA-00026 AGENCY: U.S. Small Business Administration. ACTION: Amendment 5. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the State of Iowa (FEMA- 1930-DR...

75 FR 57996 - Iowa Disaster Number IA-00026

Science.gov (United States)