WorldWideScience

Sample records for group cc stop

  1. One Stop Group Law Shop?

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2012-01-01

    The article, which is the editorial for February 2012 i European Company Law, argues that the EU must introduce a directive offering the possibility to a European cross-border group of being treated, for company law reasons, in any EU country according to the same provisions which are in force in...

  2. Asynchronous Group Key Distribution on top of the CC2420 Security Mechanisms for Sensor Networks

    DEFF Research Database (Denmark)

    Hansen, Morten Tranberg

    2009-01-01

    scheme with no time synchronization requirements. The scheme decreases the number of key updates by providing them on an as needed basis according to the amount of network traffic. We evaluate the CC2420 radio security mechanism and show how to use it as a basis to implement secure group communication......A sensor network is a network consisting of small, inexpensive, low-powered sensor nodes that communicate to complete a common task. Sensor nodes are characterized by having limited communication and computation capabilities, energy, and storage. They often are deployed in hostile environments...... creating a demand for encryption and authentication of the messages sent between them. Due to severe resource constraints on the sensor nodes, efficient key distribution schemes and secure communication protocols with low overhead are desired. In this paper we present an asynchronous group key distribution...

  3. Multi-arm group sequential designs with a simultaneous stopping rule.

    Science.gov (United States)

    Urach, S; Posch, M

    2016-12-30

    Multi-arm group sequential clinical trials are efficient designs to compare multiple treatments to a control. They allow one to test for treatment effects already in interim analyses and can have a lower average sample number than fixed sample designs. Their operating characteristics depend on the stopping rule: We consider simultaneous stopping, where the whole trial is stopped as soon as for any of the arms the null hypothesis of no treatment effect can be rejected, and separate stopping, where only recruitment to arms for which a significant treatment effect could be demonstrated is stopped, but the other arms are continued. For both stopping rules, the family-wise error rate can be controlled by the closed testing procedure applied to group sequential tests of intersection and elementary hypotheses. The group sequential boundaries for the separate stopping rule also control the family-wise error rate if the simultaneous stopping rule is applied. However, we show that for the simultaneous stopping rule, one can apply improved, less conservative stopping boundaries for local tests of elementary hypotheses. We derive corresponding improved Pocock and O'Brien type boundaries as well as optimized boundaries to maximize the power or average sample number and investigate the operating characteristics and small sample properties of the resulting designs. To control the power to reject at least one null hypothesis, the simultaneous stopping rule requires a lower average sample number than the separate stopping rule. This comes at the cost of a lower power to reject all null hypotheses. Some of this loss in power can be regained by applying the improved stopping boundaries for the simultaneous stopping rule. The procedures are illustrated with clinical trials in systemic sclerosis and narcolepsy. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

  4. Safety impacts of platform tram stops on pedestrians in mixed traffic operation: A comparison group before-after crash study.

    Science.gov (United States)

    Naznin, Farhana; Currie, Graham; Logan, David; Sarvi, Majid

    2016-01-01

    Tram stops in mixed traffic environments present a variety of safety, accessibility and transport efficiency challenges. In Melbourne, Australia the hundred year-old electric tram system is progressively being modernized to improve passenger accessibility. Platform stops, incorporating raised platforms for level entry into low floor trams, are being retro-fitted system-wide to replace older design stops. The aim of this study was to investigate the safety impacts of platform stops over older design stops (i.e. Melbourne safety zone tram stops) on pedestrians in the context of mixed traffic tram operation in Melbourne, using an advanced before-after crash analysis approach, the comparison group (CG) method. The CG method evaluates safety impacts by taking into account the general trends in safety and the unobserved factors at treatment and comparison sites that can alter the outcomes of a simple before-after analysis. The results showed that pedestrian-involved all injury crashes reduced by 43% after platform stop installation. This paper also explores a concern that the conventional CG method might underestimate safety impacts as a result of large differences in passenger stop use between treatment and comparison sites, suggesting differences in crash risk exposure. To adjust for this, a modified analysis explored crash rates (crash counts per 10,000 stop passengers) for each site. The adjusted results suggested greater reductions in pedestrian-involved crashes after platform stop installation: an 81% reduction in pedestrian-involved all injury crashes and 86% reduction in pedestrian-involved FSI crashes, both are significant at the 95% level. Overall, the results suggest that platform stops have considerable safety benefits for pedestrians. Implications for policy and areas for future research are explored. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Comparison of the Cc and R3c space groups for the superlattice phase of Pb(Zr0.52Ti0.48)O3

    International Nuclear Information System (INIS)

    Ranjan, Rajeev; Singh, Akhilesh Kumar; Ragini; Pandey, Dhananjai

    2005-01-01

    Recent controversy about the space group of the low temperature superlattice phase of Pb(Zr 0.52 Ti 0.48 )O 3 is settled. It is shown that the R3c space group for the superlattice phase cannot correctly account for the peak positions of the superlattice reflections present in the neutron diffraction patterns. The correct space group is reconfirmed to be Cc. A comparison of the atomic coordinates of Cc and Cm space groups is also presented to show that in the absence of superlattice reflections, as is the case with x-ray diffraction data, one would land up in the Cm space group. This superlattice phase is found to coexist with another monoclinic phase of the Cm space group

  6. Readthrough of stop codons by use of aminoglycosides in cells from xeroderma pigmentosum group C patients.

    Science.gov (United States)

    Kuschal, Christiane; Khan, Sikandar G; Enk, Benedikt; DiGiovanna, John J; Kraemer, Kenneth H

    2015-04-01

    Readthrough of premature termination (stop) codons (PTC) is a new approach to treatment of genetic diseases. We recently reported that readthrough of PTC in cells from some xeroderma pigmentosum complementation group C (XP-C) patients could be achieved with the aminoglycosides geneticin or gentamicin. We found that the response depended on several factors including the PTC sequence, its location within the gene and the aminoglycoside used. Here, we extended these studies to investigate the effects of other aminoglycosides that are already on the market. We reasoned that topical treatment could deliver much higher concentrations of drug to the skin, the therapeutic target, and thus increase the therapeutic effect while reducing renal or ototoxicity in comparison with systemic treatment. Our prior clinical studies indicated that only a few percent of normal XPC expression was associated with mild clinical disease. We found minimal cell toxicity in the XP-C cells with several aminoglycosides. We found increased XPC mRNA expression in PTC-containing XP-C cells with G418, paromomycin, neomycin and kanamycin and increased XPC protein expression with G418. We conclude that in selected patients with XP, topical PTC therapy can be investigated as a method of personalized medicine to alleviate their cutaneous symptoms. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

  7. High prevalence of hepatitis B virus genotype C/C1 in the Minangkabau ethnic group in Indonesia

    Directory of Open Access Journals (Sweden)

    Siburian Marlinang D

    2013-01-01

    Full Text Available Abstract Background The Minangkabau is one of the major ethnic groups in Indonesia. Previous studies with a limited number of samples have shown a different prevalence of HBV/C in the Minangkabau compared to the Indonesian population in general. The aim of this study was to assess the HBV genotype distribution pattern and the prevalence of pre-S, T1753V and A1762T/G1764A mutations among the Minangkabau HBV carriers. The samples were collected from Padang, West Sumatera and from western Java. Mixed primers for specific genotypes were used to determine the HBV genotype. Pre-S or S genes were amplified, sequenced and aligned with reference sequences from GenBank to derive a phylogenetic tree for subgenotyping. Pre-S genes were also analyzed for mutations. The basal core promoter (BCP region was amplified and directly sequenced to analyze T1753V and A1762T/G1764A mutations. Results The predominant HBV genotype among the Minangkabau HBV carriers (n=117 was C (72.6% followed by B (24.8% and co-infection with B and C (2.6%. The prevalence of pre-S mutations, including both the pre-S deletion and pre-S2 start codon mutation, was 41.0%, and the T1753V and A1762T/G1764A mutations were found in 51.9% and 71.2% respectively. HBV/C1 was the predominant HBV subgenotype in the Minangkabau HBV carriers, and was found in 66.2%, followed by B3, B7, C8, B2, B9, C2, and C10 (18.3%, 7.0%, 2.8%, 1.4%, 1.4%, 1.4%, and 1.4% respectively. From samples that were found to be co-infected with HBV B and C, two samples were successfully cloned and subgenotyped, including one with mixed subgenotypes of B3 and C1, and another one with mixed subgenotypes of B7, C1, putative intergenotypic of B/A, and C/A. Furthermore, three samples from donors of non-Minangkabau ethnicity from Padang were found to be infected with an intragenotypic recombination form, including a putative recombinant of B8/B3 and B9/B7. Conclusion HBV/C with subgenotype C1 was the predominant HBV genotype among

  8. Genomic analysis reveals multi-drug resistance clusters in Group B Streptococcus CC17 hypervirulent isolates causing neonatal invasive disease in southern mainland China

    Directory of Open Access Journals (Sweden)

    Edmondo Campisi

    2016-08-01

    Full Text Available Neonatal invasive disease caused by group B Streptococcus (GBS represents a significant public health care concern globally. However, data related to disease burden, serotype distribution and molecular epidemiology in China and other Asian countries are very few and specifically relative to confined regions. The aim of this study was to investigate the genetic characteristics of GBS isolates recovered from neonates with invasive disease during 2013-2014 at Guangzhou and Changsha hospitals in southern mainland China. We assessed the capsular polysaccharide (CPS type, pilus islands (PIs distribution and hvgA gene presence in a panel of 26 neonatal clinical isolates, of which 8 were recovered from Early Onset Disease (EOD and 18 from Late Onset Disease (LOD. Among 26 isolates examined, five serotypes were identified. Type III was the most represented (15 cases, particularly among LOD strains (n=11, followed by types Ib (n=5, V (n=3, Ia (n=2 and II (n=1. We performed whole-genome sequencing (WGS analysis and antimicrobial susceptibility testing on the 14 serotype III isolates belonging to the hypervirulent Clonal Complex 17 (serotype III-CC17.The presence of PI-2b alone was associated with 13 out of 14 serotype III-CC17 strains. Genome analysis led us to identify two multi-drug resistance gene clusters harbored in two new versions of integrative and conjugative elements (ICEs, carrying five or eight antibiotic resistance genes, respectively. These ICEs replaced the 16 kb-locus that normally contains the PI-1 operon. All isolates harboring the identified ICEs showed multiple resistances to aminoglycoside, macrolide and tetracycline antibiotic classes. In conclusion, we report the first whole-genome sequence analysis of 14 GBS serotype III-CC17 strains isolated in China, representing the most prevalent lineage causing neonatal invasive disease. The acquisition of newly identified ICEs conferring multiple antibiotic resistances could in part explain

  9. Slow and stopped light in active gain composite materials of metal nanoparticles. Ultralarge group index-bandwidth product predicted

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwang-Hyon; Choe, Song-Hyok [Institute of Lasers, State Academy of Sciences, Unjong District, Pyongyang (Korea, Democratic People' s Republic of)

    2017-08-15

    Chip-compatible slow light devices with large group index-bandwidth products and low losses are of great interest in the community of modern photonics. In this work, active gain materials containing metal nanoparticles are proposed as the slow and stopped light materials. Gain-assisted high field enhancement in metal nanoparticles and the resultant strong dispersion lead to such phenomena. From the Maxwell-Garnett model, it is revealed that the metal nanocomposite exhibits the infinitely large group index when the gain of the host medium and the filling factor of metal nanoparticles satisfy a critical condition. For the gain of the host above the critical value, one can observe slowing down effect with amplification of light pulses. Significantly large group index-bandwidth products, which vary from a few to several thousand or even infinity depending on the gain value of the host medium, have been numerically predicted in active silica glasses containing spheroidal metal nanoparticles, as examples. The proposed scheme inherently provides the widely varying operating spectral range by changing the aspect ratio of metal nanoparticles and chip-compatibility with low cost. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. Pyridine group assisted addition of diazo-compounds to imines in the 3-CC reaction of 2-aminopyridines, aldehydes, and diazo-compounds.

    Science.gov (United States)

    Gulevich, Anton V; Helan, Victoria; Wink, Donald J; Gevorgyan, Vladimir

    2013-02-15

    A novel three-component coupling (3-CC) reaction of 2-aminoazines, aromatic aldehydes, and diazo-compounds producing polyfunctional β-amino-α-diazo-compounds has been developed. The reaction features an unprecedented heterocycle-assisted addition of a diazo-compound to an imine. The obtained diazoesters were efficiently converted into valuable heterocycles as well as β-amino acid derivatives.

  11. Dreamweaver CC for dummies

    CERN Document Server

    Warner, Janine

    2013-01-01

    Turn your wonderful website dreams into robust realities with the help of Dreamweaver CC For Dummies! Creating dynamic websites is easy with Dreamweaver CC and this friendly, full-color guide. Updated for the latest version of Adobe's world-renowned web development tool, Dreamweaver CC For Dummies covers all aspects of creating websites, from understanding web design basics to using style sheets, integrating multimedia, implementing responsive design, testing and publishing your sites, and more. With the professional guidance of Web design expert Jan

  12. Pyridine Group-Assisted Addition of Diazo-Compounds to Imines in the 3-CC Reaction of 2-Aminopyridines, Aldehydes, and Diazo-Compounds

    Science.gov (United States)

    Gulevich, Anton V.; Helan, Victoria; Wink, Donald J.

    2013-01-01

    A novel three-component (3-CC) coupling reaction of 2-aminoazines, aromatic aldehydes and diazo-compounds producing polyfunctional β-amino-α-diazo-compounds has been developed. The reaction features an unprecedented heterocycle-assisted addition of a diazo-compound to an imine. The obtained diazoesters were efficiently converted into valuable heterocycles, as well as to β-amino acid derivatives. PMID:23373731

  13. Unusual C-C bond cleavage in the formation of amine-bis(phenoxy) group 4 benzyl complexes: Mechanism of formation and application to stereospecific polymerization

    KAUST Repository

    Gowda, Ravikumar R.

    2014-08-11

    Group 4 tetrabenzyl compounds MBn4 (M = Zr, Ti), upon protonolysis with an equimolar amount of the tetradentate amine-tris(phenol) ligand N[(2,4-tBu2C6H2(CH 2)OH]3 in toluene from -30 to 25 °C, unexpectedly lead to amine-bis(phenoxy) dibenzyl complexes, BnCH2N[(2,4- tBu2C6H2(CH2)O] 2MBn2 (M = Zr (1), Ti (2)) in 80% (1) and 75% (2) yields. This reaction involves an apparent cleavage of the >NCH2-ArOH bond (loss of the phenol in the ligand) and formation of the >NCH 2-CH2Bn bond (gain of the benzyl group in the ligand). Structural characterization of 1 by X-ray diffraction analysis confirms that the complex formed is a bis(benzyl) complex of Zr coordinated by a newly derived tridentate amine-bis(phenoxy) ligand arranged in a mer configuration in the solid state. The abstractive activation of 1 and 2 with B(C6F 5)3·THF in CD2Cl2 at room temperature generates the corresponding benzyl cations {BnCH2N[(2,4- tBu2C6H2(CH2)O] 2MBn(THF)}+[BnB(C6F5) 3]- (M = Zr (3), Ti, (4)). These cationic complexes, along with their analogues derived from (imino)phenoxy tri- and dibenzyl complexes, [(2,6-iPr2C6H3)N=C(3,5- tBu2C6H2)O]ZrBn3 (5) and [2,4-Br2C6H2(O)(6-CH2(NC 5H9))CH2N=CH(2-adamantyl-4-MeC 6H2O)]ZrBn2 (6), have been found to effectively polymerize the biomass-derived renewable β-methyl-α-methylene- γ-butyrolactone (βMMBL) at room temperature into the highly stereoregular polymer PβMMBL with an isotacticity up to 99% mm. A combined experimental and DFT study has yielded a mechanistic pathway for the observed unusual C-C bond cleavage in the present protonolysis reaction between ZrBn4 and N[(2,4-tBu2C 6H2(CH2)OH]3 for the formation of complex 1, which involves the benzyl radical and the Zr(III) species, resulting from thermal and photochemical decomposition of ZrBn4, followed by a series of reaction sequences consisting of protonolysis, tautomerization, H-transfer, oxidation, elimination, and radical coupling. © 2014 American Chemical Society.

  14. Staphylococcus aureus CC398

    DEFF Research Database (Denmark)

    Price, Lance B.; Stegger, Marc; Hasman, Henrik

    2012-01-01

    Since its discovery in the early 2000s, methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) has become a rapidly emerging cause of human infections, most often associated with livestock exposure. We applied whole-genome sequence typing to characterize a diverse collection...... of CC398 isolates (n = 89), including MRSA and methicillin-susceptible S. aureus (MSSA) from animals and humans spanning 19 countries and four continents. We identified 4,238 single nucleotide polymorphisms (SNPs) among the 89 core genomes. Minimal homoplasy (consistency index = 0.9591) was detected...... among parsimony-informative SNPs, allowing for the generation of a highly accurate phylogenetic reconstruction of the CC398 clonal lineage. Phylogenetic analyses revealed that MSSA from humans formed the most ancestral clades. The most derived lineages were composed predominantly of livestock...

  15. Illustrator CC digital classroom

    CERN Document Server

    Smith, Jennifer

    2013-01-01

    A complete training package lets you learn Adobe Illustrator CC at your own speed Adobe Illustrator is the leading drawing and illustration software used to create artwork for a variety of media. This book-and-DVD package provides 13 self-paced lessons that get you up to speed on the latest version of Illustrator (Creative Cloud). Step-by-step instructions in the full-color book are supported by video tutorials on the DVD. Together, these tools will help you learn Adobe Illustrator basics, essential skills, and all the new capabilities in Illustrator CC-in no time.  Includes step-by-step in

  16. Photoshop CC for dummies

    CERN Document Server

    Bauer, Peter

    2013-01-01

    Stretch your creativity beyond the cloud with this fully-updated Photoshop guide!Photoshop puts amazing design and photo-editing tools in the hands of creative professionals and hobbyists everywhere, and the latest version - Photoshop CC - is packed with even more powerful tools to help you manage and enhance your images. This friendly, full-color guide introduces you to the basics of Photoshop CC and provides clear explanations of the menus, panels, tools, options, and shortcuts you'll use the most. Plus, you'll learn valuable tips for fixing common photo flaws, improvin

  17. Behavior change techniques used in group-based behavioral support by the English stop-smoking services and preliminary assessment of association with short-term quit outcomes.

    Science.gov (United States)

    West, Robert; Evans, Adam; Michie, Susan

    2011-12-01

    To develop a reliable coding scheme for components of group-based behavioral support for smoking cessation, to establish the frequency of inclusion in English Stop-Smoking Service (SSS) treatment manuals of specific components, and to investigate the associations between inclusion of behavior change techniques (BCTs) and service success rates. A taxonomy of BCTs specific to group-based behavioral support was developed and reliability of use assessed. All English SSSs (n = 145) were contacted to request their group-support treatment manuals. BCTs included in the manuals were identified using this taxonomy. Associations between inclusion of specific BCTs and short-term (4-week) self-reported quit outcomes were assessed. Fourteen group-support BCTs were identified with >90% agreement between coders. One hundred and seven services responded to the request for group-support manuals of which 30 had suitable documents. On average, 7 BCTs were included in each manual. Two were positively associated with 4-week quit rates: "communicate group member identities" and a "betting game" (a financial deposit that is lost if a stop-smoking "buddy" relapses). It is possible to reliably code group-specific BCTs for smoking cessation. Fourteen such techniques are present in guideline documents of which 2 appear to be associated with higher short-term self-reported quit rates when included in treatment manuals of English SSSs.

  18. Unusual C-C bond cleavage in the formation of amine-bis(phenoxy) group 4 benzyl complexes: Mechanism of formation and application to stereospecific polymerization

    KAUST Repository

    Gowda, Ravikumar R.; Caporaso, Lucia; Cavallo, Luigi; Chen, Eugene You Xian

    2014-01-01

    Group 4 tetrabenzyl compounds MBn4 (M = Zr, Ti), upon protonolysis with an equimolar amount of the tetradentate amine-tris(phenol) ligand N[(2,4-tBu2C6H2(CH 2)OH]3 in toluene from -30 to 25 °C, unexpectedly lead to amine-bis(phenoxy) dibenzyl

  19. Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China.

    Science.gov (United States)

    Zhang, Chan; He, Yan; Shan, Ke-Ren; Tan, Kui; Zhang, Ting; Wang, Chan-Juan; Guan, Zhi-Zhong

    2018-02-01

    Objective To determine whether genetic polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A ( UGT1A) and the C-C motif chemokine receptor 5 ( CCR5) genes are associated with hepatitis B virus (HBV) infection in Yi, Yao and Han ethnic groups in the Guizhou Province of China. Methods The study enrolled subjects with and without HBV infection. Whole blood was used for DNA genotyping using standard techniques. The study determined the frequencies of several polymorphic alleles ( UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5Δ32 [rs333]) and then characterized their relationship with HBV infection. Results A total of 404 subjects were enrolled in the study: 138 from the Yao group, 101 from the Yi group and 165 from the Han group. There was a significant difference in the frequency of UGT1A1 rs8175347 polymorphisms among the three groups. The rates of 7TA carriers of UGT1A1 rs8175347 in all three groups were significantly higher than the other genotypes. Individuals with genotype AA of UGT1A6 rs2070959 in the Yi group had a higher risk for HBV infection than in the Yao and Han groups. The frequency of genotype GG in CCR5-59029 in the Yao group was significantly higher than in the Yi group. The genotypes of CCR5Δ32 were not associated with HBV infection. Conclusion These findings provide genetic and epidemiological evidence for an association of UGT1A and CCR5-59029 polymorphisms with HBV infection in Chinese Yi and Yao populations.

  20. Learning Based on CC1 and CC4 Neural Networks

    OpenAIRE

    Kak, Subhash

    2017-01-01

    We propose that a general learning system should have three kinds of agents corresponding to sensory, short-term, and long-term memory that implicitly will facilitate context-free and context-sensitive aspects of learning. These three agents perform mututally complementary functions that capture aspects of the human cognition system. We investigate the use of CC1 and CC4 networks for use as models of short-term and sensory memory.

  1. LHC Availability 2017: Technical Stop 1 to Technical Stop 2

    CERN Document Server

    Todd, Benjamin; Apollonio, Andrea; Walsh, David John; CERN. Geneva. ATS Department

    2017-01-01

    This document summarises the LHC machine availability for the period of Technical Stop 1 (TS1) to Technical Stop 2 (TS2) in 2017. This period was dedicated to proton physics with a bunch spacing of 25ns. This note has been produced and ratified by the Availability Working Group which has complied fault information for the period in question using the Accelerator Fault Tracker.

  2. An Exploratory Analysis of the Smoking and Physical Activity Outcomes From a Pilot Randomized Controlled Trial of an Exercise Assisted Reduction to Stop Smoking Intervention in Disadvantaged Groups.

    Science.gov (United States)

    Thompson, Tom Paul; Greaves, Colin J; Ayres, Richard; Aveyard, Paul; Warren, Fiona C; Byng, Richard; Taylor, Rod S; Campbell, John L; Ussher, Michael; Green, Colin; Michie, Susan; West, Robert; Taylor, Adrian

    2016-03-01

    Economically disadvantaged smokers not intending to stop may benefit from interventions aimed at reducing their smoking. This study assessed the effects of a behavioral intervention promoting an increase in physical activity versus usual care in a pilot randomized controlled trial. Disadvantaged smokers who wanted to reduce but not quit were randomized to either a counseling intervention of up to 12 weeks to support smoking reduction and increased physical activity (n = 49) or usual care (n = 50). Data at 16 weeks were collected for various smoking and physical activity outcomes. Primary analyses consisted of an intention to treat analysis based on complete case data. Secondary analyses explored the impact of handling missing data. Compared with controls, intervention smokers were more likely to initiate a quit attempt (36 vs. 10%; odds ratio 5.05, [95% CI: 1.10; 23.15]), and a greater proportion achieved at least 50% reduction in cigarettes smoked (63 vs. 32%; 4.21 [1.32; 13.39]). Postquit abstinence measured by exhaled carbon monoxide at 4-week follow-up showed promising differences between groups (23% vs. 6%; 4.91 [0.80; 30.24]). No benefit of intervention on physical activity was found. Secondary analyses suggested that the standard missing data assumption of "missing" being equivalent to "smoking" may be conservative resulting in a reduced intervention effect. A smoking reduction intervention for economically disadvantaged smokers which involved personal support to increase physical activity appears to be more effective than usual care in achieving reduction and may promote cessation. The effect does not appear to be influenced by an increase in physical activity. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Stop smoking support programs

    Science.gov (United States)

    Smokeless tobacco - stop smoking programs; Stop smoking techniques; Smoking cessation programs; Smoking cessation techniques ... You can find out about smoking cessation programs from: Your ... Your employer Your local health department The National Cancer ...

  4. GMSB with light stops

    Energy Technology Data Exchange (ETDEWEB)

    Delgado, Antonio [Department of Physics, University of Notre Dame,225 Nieuwland Science Hall, IN 46556, Notre Dame (United States); Theory Division, Physics Department CERN,CH-1211 Geneva 23 (Switzerland); Garcia-Pepin, Mateo [Institut de Física d’Altes Energies, Universitat Autònoma de Barcelona,08193 Bellaterra, Barcelona (Spain); Quiros, Mariano [ICREA at Institut de Física d’Altes Energies, Universitat Autònoma de Barcelona,08193 Bellaterra, Barcelona (Spain)

    2015-08-31

    Gauge mediated supersymmetry breaking (GMSB) is an elegant mechanism to transmit supersymmetry breaking from the hidden to the MSSM observable sector, which solves the supersymmetric flavor problem. However, the smallness of the generated stop mixing requires superheavy stops to reproduce the experimental value of the Higgs mass. A possible way out is to extend the MSSM Higgs sector with singlets and/or triplets providing extra tree-level corrections to the Higgs mass. Singlets will not get any soft mass from GMSB and triplets will contribute to the ρ parameter which could be an issue. In this paper we explore the second possibility by introducing extra supersymmetric triplets with hypercharges Y=(0,±1), with a tree-level custodial SU(2){sub L}⊗SU(2){sub R} global symmetry in the Higgs sector protecting the ρ parameter: a supersymmetric generalization of the Georgi-Machacek model, dubbed as supersymmetric custodial triplet model (SCTM). The renormalization group running from the messenger to the electroweak scale mildly breaks the custodial symmetry. We will present realistic low-scale scenarios (with the NLSP being a Bino-like neutralino or the right-handed stau) based on general (non-minimal) gauge mediation and consistent with all present experimental data. Their main features are: i) Light (∼1 TeV) stops; ii) Exotic couplings (H{sup ±}W{sup ∓}Z and H{sup ±±}W{sup ∓}W{sup ∓}) absent in the MSSM and proportional to the triplets VEV, v{sub Δ}; and, iii) A possible (measurable) universality breaking of the Higgs couplings λ{sub WZ}=r{sub WW}/r{sub ZZ}≠1.

  5. Teach yourself visually Photoshop CC

    CERN Document Server

    Wooldridge, Mike

    2013-01-01

    Get savvy with the newest features and enhancements of Photoshop CC The newest version of Photoshop boasts enhanced and new features that afford you some amazing and creative ways to create images with impact, and this popular guide gets visual learners up to speed quickly. Packed with colorful screen shots that illustrate the step-by-step instructions, this visual guide is perfect for Photoshop newcomers as well as experienced users who are looking for some beginning to intermediate-level techniques to give their projects the ""wow"" factor! Veteran and bestselling authors Mik

  6. Adobe Photoshop CC for photographers

    CERN Document Server

    Evening, Martin

    2014-01-01

    Adobe Photoshop for Photographers 2014 Release by Photoshop hall-of-famer and acclaimed digital imaging professional Martin Evening has been fully updated to include detailed instruction for all of the updates to Photoshop CC 2014 on Adobe's Creative Cloud, including significant new features, such as Focus Area selections, enhanced Content-Aware filling, and new Spin and Path blur gallery effects. This guide covers all the tools and techniques photographers and professional image editors need to know when using Photoshop, from workflow guidance to core skills to advanced techniques for profess

  7. Stop Negative Thinking Effects for Drug Dependence

    OpenAIRE

    Windiarti, Sri Endang; Indriati, Indriati; Surachmi, Fajar

    2013-01-01

    The purpose of this study was to determine the effect of therapy stop thinking negatively against drug addiction in Rehabilitation Orphanage Rumah Damai Gunung Pati Semarang. This research is quasy experiment with pretest - posttes without the control group design. Thirty respondents were taken to the reseach sujects. Stop thinking negative therapy before and after thebehavior of drug addiction there are differences (t = 0.00), so it can be stated that the therapy stop thinking negatively inf...

  8. "CAN Stop"--implementation and evaluation of a secondary group prevention for adolescent and young adult cannabis users in various contexts--study protocol.

    Science.gov (United States)

    Baldus, Christiane; Miranda, Alejandra; Weymann, Nina; Reis, Olaf; Moré, Kerstin; Thomasius, Rainer

    2011-04-18

    Current research shows that overall numbers for cannabis use among adolescents and young adults dropped in recent years. However, this trend is much less pronounced in continuous cannabis use. With regard to the heightened risk for detrimental health- and development-related outcomes, adolescents and young adults with continuous cannabis use need special attention. The health services structure for adolescents and young adults with substance related problems in Germany, is multifaceted, because different communal, medical and judicial agencies are involved. This results in a rather decentralized organizational structure of the help system. This and further system-inherent characteristics make the threshold for young cannabis users rather high. Because of this, there is a need to establish evidence-based low-threshold help options for young cannabis users, which can be easily disseminated. Therefore, a training programme for young cannabis users (age 14-21) was developed in the "CAN Stop" project. Within the project, we seek to implement and evaluate the training programme within different institutions of the help system. The evaluation is sensitive to the different help systems and their specific prerequisites. Moreover, within this study, we also test the practicability of a training provision through laypersons. The CAN Stop study is a four-armed randomized wait-list controlled trial. The four arms are needed for the different help system settings, in which the CAN Stop training programme is evaluated: (a) the drug addiction aid and youth welfare system, (b) the out-patient medical system, (c) the in-patient medical system and (d) prisons for juvenile offenders. Data are collected at three points, before and after the training or a treatment as usual, and six months after the end of either intervention. The CAN Stop study is expected to provide an evidence-based programme for young cannabis users seeking to reduce or quit their cannabis use. Moreover, we seek to

  9. "CAN Stop" - Implementation and evaluation of a secondary group prevention for adolescent and young adult cannabis users in various contexts - study protocol

    Directory of Open Access Journals (Sweden)

    Moré Kerstin

    2011-04-01

    Full Text Available Abstract Background Current research shows that overall numbers for cannabis use among adolescents and young adults dropped in recent years. However, this trend is much less pronounced in continuous cannabis use. With regard to the heightened risk for detrimental health- and development-related outcomes, adolescents and young adults with continuous cannabis use need special attention. The health services structure for adolescents and young adults with substance related problems in Germany, is multifaceted, because different communal, medical and judicial agencies are involved. This results in a rather decentralized organizational structure of the help system. This and further system-inherent characteristics make the threshold for young cannabis users rather high. Because of this, there is a need to establish evidence-based low-threshold help options for young cannabis users, which can be easily disseminated. Therefore, a training programme for young cannabis users (age 14-21 was developed in the "CAN Stop" project. Within the project, we seek to implement and evaluate the training programme within different institutions of the help system. The evaluation is sensitive to the different help systems and their specific prerequisites. Moreover, within this study, we also test the practicability of a training provision through laypersons. Methods/Design The CAN Stop study is a four-armed randomized wait-list controlled trial. The four arms are needed for the different help system settings, in which the CAN Stop training programme is evaluated: (a the drug addiction aid and youth welfare system, (b the out-patient medical system, (c the in-patient medical system and (d prisons for juvenile offenders. Data are collected at three points, before and after the training or a treatment as usual, and six months after the end of either intervention. Discussion The CAN Stop study is expected to provide an evidence-based programme for young cannabis users

  10. Lifespan changes in global and selective stopping and performance adjustments

    Directory of Open Access Journals (Sweden)

    Maria Christina Van De Laar

    2011-12-01

    Full Text Available This study examined stopping and performance adjustments in four age groups (M ages: 8, 12, 21, and 76 years. All participants performed on three tasks, a standard two-choice task and the same task in which stop-signal trials were inserted requiring either the suppression of the response activated by the choice stimulus (global stop task or the suppression of the response when one stop signal was presented but not when the other stop signal occurred (selective stop task. The results showed that global stopping was faster than selective stopping in all age groups. Global stopping matured more rapidly than selective stopping. The developmental gain in stopping was considerably more pronounced compared to the loss observed during senescence. All age groups slowed the response on trials without a stop signal in the stop task compared to trials in the choice task, the elderly in particular. In addition, all age groups slowed on trials following stop-signal trials, except the elderly who did not slow following successful inhibits. By contrast, the slowing following failed inhibits was disproportionally larger in the elderly compared to young adults. Finally, sequential effects did not alter the pattern of performance adjustments. The results were interpreted in terms of developmental change in the balance between proactive and reactive control.

  11. Lifespan Changes in Global and Selective Stopping and Performance Adjustments

    Science.gov (United States)

    van de Laar, Maria C.; van den Wildenberg, Wery P. M.; van Boxtel, Geert J. M.; van der Molen, Maurits W.

    2011-01-01

    This study examined stopping and performance adjustments in four age groups (M ages: 8, 12, 21, and 76 years). All participants performed on three tasks, a standard two-choice task and the same task in which stop-signal trials were inserted requiring either the suppression of the response activated by the choice stimulus (global stop task) or the suppression of the response when one stop-signal was presented but not when the other stop-signal occurred (selective stop task). The results showed that global stopping was faster than selective stopping in all age groups. Global stopping matured more rapidly than selective stopping. The developmental gain in stopping was considerably more pronounced compared to the loss observed during senescence. All age groups slowed the response on trials without a stop-signal in the stop task compared to trials in the choice task, the elderly in particular. In addition, all age groups slowed on trials following stop-signal trials, except the elderly who did not slow following successful inhibits. By contrast, the slowing following failed inhibits was disproportionally larger in the elderly compared to young adults. Finally, sequential effects did not alter the pattern of performance adjustments. The results were interpreted in terms of developmental change in the balance between proactive and reactive control. PMID:22180746

  12. Agutaynen Glottal Stop.

    Science.gov (United States)

    Quakenbush, J. Stephen

    A study investigated the phonemic and morphophonemic patterning of the glottal stop in Agutaynen, a Meso-Philippine language, and some comparison with two northern Philippine languages. Agutaynen glottal stop has as its sole origin a neutralization of contrast rule, the operation of which can be noted in three different linguistic environments.…

  13. Shewanella oneidensis cytochrome c nitrite reductase (ccNiR) does not disproportionate hydroxylamine to ammonia and nitrite, despite a strongly favorable driving force.

    Science.gov (United States)

    Youngblut, Matthew; Pauly, Daniel J; Stein, Natalia; Walters, Daniel; Conrad, John A; Moran, Graham R; Bennett, Brian; Pacheco, A Andrew

    2014-04-08

    Cytochrome c nitrite reductase (ccNiR) from Shewanella oneidensis, which catalyzes the six-electron reduction of nitrite to ammonia in vivo, was shown to oxidize hydroxylamine in the presence of large quantities of this substrate, yielding nitrite as the sole free nitrogenous product. UV-visible stopped-flow and rapid-freeze-quench electron paramagnetic resonance data, along with product analysis, showed that the equilibrium between hydroxylamine and nitrite is fairly rapidly established in the presence of high initial concentrations of hydroxylamine, despite said equilibrium lying far to the left. By contrast, reduction of hydroxylamine to ammonia did not occur, even though disproportionation of hydroxylamine to yield both nitrite and ammonia is strongly thermodynamically favored. This suggests a kinetic barrier to the ccNiR-catalyzed reduction of hydroxylamine to ammonia. A mechanism for hydroxylamine reduction is proposed in which the hydroxide group is first protonated and released as water, leaving what is formally an NH2(+) moiety bound at the heme active site. This species could be a metastable intermediate or a transition state but in either case would exist only if it were stabilized by the donation of electrons from the ccNiR heme pool into the empty nitrogen p orbital. In this scenario, ccNiR does not catalyze disproportionation because the electron-donating hydroxylamine does not poise the enzyme at a sufficiently low potential to stabilize the putative dehydrated hydroxylamine; presumably, a stronger reductant is required for this.

  14. Luminescent beam stop

    Energy Technology Data Exchange (ETDEWEB)

    Bryant, Diane; Morton, Simon A.

    2017-10-25

    This disclosure provides systems, methods, and apparatus related to beam stops. In one aspect, a device comprises a luminescent material, a beam stop plate, and an optical fiber. The luminescent material is a parallelepiped having a first side and a second side that are squares and having a third side that is a rectangle or a square. The first side and the second side are perpendicular to the third side. The beam stop plate is attached to the first side of the luminescent material. The optical fiber has a first end and a second end, with the first end of the optical fiber attached to the third side of the luminescent material.

  15. "Stop Diabetes Now!"

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Diabetes "Stop Diabetes Now!" Past Issues / Fall 2009 Table of Contents ... Tips for Seniors at Risk for Type 2 Diabetes Lifestyle changes that lead to weight loss—such ...

  16. Depression - stopping your medicines

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000570.htm Depression - stopping your medicines To use the sharing features ... prescription medicines you may take to help with depression, anxiety, or pain. Like any medicine, there are ...

  17. Energy Materials Coordinating Committee (EMaCC)

    Energy Technology Data Exchange (ETDEWEB)

    1991-05-31

    This report summarizes EMaCC activities for fiscal year 1990 and describes the materials research programs of various offices and divisions within the department. The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further the effective use of materials expertise within the department. (JL)

  18. Les cardiopathies congenitales (cc) au Togo aspects ...

    African Journals Online (AJOL)

    The petrology of the. Follot (16.96%) and the CIA (06.25%) 112 patients have been transferred to foreign countries of which 74.10% Suisse 107 CC have been operated. The evolution has been favourable in 89.18%. In Togo, the discovery of the CC has been done lately posing therefore a problem of therapeutic choice.

  19. Identification of a cobia (Rachycentron canadum) CC chemokine gene and its involvement in the inflammatory response.

    Science.gov (United States)

    Su, Youlu; Guo, Zhixun; Xu, Liwen; Jiang, Jingzhe; Wang, Jiangyong; Feng, Juan

    2012-01-01

    The chemokines regulate immune cell migration under inflammatory and physiological conditions. We investigated a CC chemokine gene (RcCC1) from cobia (Rachycentron canadum). The full-length RcCC1 cDNA is comprised 673 nucleotides and encodes a four-cysteine arrangement 99-amino-acid protein typical of known CC chemokines. The genomic DNA of RcCC1 consists of three exons and two introns. Phylogenetic analysis showed that RcCC1 was closest to the MIP group of CC chemokines. Quantitative real-time RT-PCR (qRT-PCR) analysis revealed RcCC1 was constitutively expressed in all tissues examined, with relative strong expression in gill, blood, kidney, spleen, and head kidney. The RcCC1 transcripts in the head kidney, spleen, and liver were quickly up-regulated after stimulation with formalin-inactivated Vibrio carchariae (bacterial vaccine) or polyriboinosinic polyribocytidylic acid (poly I:C). These results indicate RcCC1 not only plays a role in homeostasis, but also may be involved in inflammatory responses to bacterial and viral infection. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Application of the RADTRAN 5 stop model

    International Nuclear Information System (INIS)

    Neuhauser, K.S.; Kanipe, R.L.; Weiner, R.F.

    1997-01-01

    A number of environmental impact analyses with the RADTRAN computer code have shown that dose to persons at stops is one of the largest components of incident-free dose during overland carriage of spent fuel and other radioactive materials (e.g., USDOE, 1994). The input data used in these analyses were taken from a 1983 study that reports actual observations of spent fuel shipments by truck. Early RADTRAN stop models, however, were insufficiently flexible to take advantage of the detailed information in the study. A more recent study of gasoline service stations that specialize in servicing large trucks, which are the most likely stop locations for shipments of Type B packages in the United States, has provided additional, detailed data on refueling/meal stops. The RADTRAN 5 computer code for transportation risk analysis allows exposures at stops to be more fully modeled than have previous releases of the code and is able to take advantage of detailed data. It is the intent of this paper first to compare results from RADTRAN and RADTRAN 5 for the old, low-resolution form of input data, and then to demonstrate what effect the new data and input format have on stop-dose estimates for an individual stop and for a hypothetical shipment route. Finally, these estimated public doses will be contrasted with doses calculated for a special population group -- inspectors

  1. Application of the radtran 5 stop model

    International Nuclear Information System (INIS)

    Neuhauser, K.S.; Kanipe, R.L.; Weiner, R.F.

    1998-01-01

    A number of environmental impact analyzes with the RADTRAN computer code have shown that dose to persons at stops is one of the largest components of incident-free dose during overland carriage of spent fuel and other radioactive materials. The input data used in these analyses were taken from a 1983 study that reports actual observations of spent fuel shipments by truck. Early RADTRAN stop models, however, were insufficiently flexible to take advantage of the detailed information in the study. A more recent study of gasoline service stations that specialize in servicing large trucks, which are the most likely stop locations for shipments of Type B packages in the United States, has provided additional, detailed data on refueling/meal stops. The RADTRAN 5 computer code for transportation risk analysis allows exposures at stops to be more fully modelled than have previous releases of the code and is able to take advantage of detailed data. It is the intent of this paper first to compare results from RADTRAN 4 and RADTRAN 5 for the old, low-resolution form of input data, and then to demonstrate what effect the new data and input format have on stop-dose estimates for an individual stop and for a hypothetical shipment route. Finally, these estimated public doses will be contrasted with doses calculated for a special population group-inspectors. (authors)

  2. Tobacco industry surveillance of public health groups: the case of STAT (Stop Teenage Addiction to Tobacco) and INFACT (Infant Formula Action Coalition).

    Science.gov (United States)

    Malone, Ruth E

    2002-06-01

    The goal of this study was to describe how the tobacco industry collects information about public health groups. Publicly available internal tobacco industry documents were reviewed and analyzed using a chronological case study approach. The industry engaged in aggressive intelligence gathering, used intermediaries to obtain materials under false pretenses, sent public relations spies to the organizations' meetings, and covertly taped strategy sessions. Other industry strategies included publicly minimizing the effects of boycotts, painting health advocates as "extreme," identifying and exploiting disagreements, and planning to "redirect the funding" of tobacco control organizations to other purposes. Public health advocates often make light of tobacco industry observers, but industry surveillance may be real, intense, and covert and may obstruct public health initiatives.

  3. Stopping the unstoppable

    CERN Multimedia

    2002-01-01

    How do you stop two very high energy proton beams circulating in opposite directions around a 27-kilometre ring? The answer is the beam dumps. Two tunnels, pointing in opposite directions, are being constructed at point 6 of the LHC. These will allow the beams to be directed into two large beam dumps housed at the ends of the tunnels.

  4. Ready to stop

    DEFF Research Database (Denmark)

    Molitoris, Joseph; Dribe, Martin

    2016-01-01

    the Roteman Database for Stockholm, Sweden between 1878 and 1926 to examine the association of socioeconomic status and fertility and the adoption of stopping behaviour during the city's transition. Using piecewise constant hazard models and logistic regression, we find that a clear class pattern arises...

  5. Synthesis and structural characterization of PHP[(C(5)Me(4))(2)], a monodentate chiral phosphine derived from intramolecular C-C coupling of tetramethylcyclopentadienyl groups: an evaluation of steric and electronic properties.

    Science.gov (United States)

    Shin, J H; Bridgewater, B M; Churchill, D G; Parkin, G

    2001-10-22

    The chiral monodentate phosphine PhP[(C(5)Me(4))(2)] is readily obtained by oxidation of the lithium complex Li(2)[PhP(C(5)Me(4))(2)] with I(2), which couples the two cyclopentadienyl groups to form a five-membered heterocyclic ring. The steric and electronic properties of PhP[(C(5)Me(4))(2)] have been evaluated by X-ray diffraction and IR spectroscopic studies on a variety of derivatives, including Ph[(C(5)Me(4))(2)]PE (E = S, Se), Cp*MCl(4)[P[(C(5)Me(4))(2)]Ph] (M = Mo, Ta), Ir[P[(C(5)Me(4))(2)]Ph](2)(CO)Cl, and CpFe(CO)[PhP[(C(5)Me(4))(2)

  6. Cohort Profile: Antiretroviral Therapy Cohort Collaboration (ART-CC)

    Science.gov (United States)

    May, Margaret T; Ingle, Suzanne M; Costagliola, Dominique; Justice, Amy C; de Wolf, Frank; Cavassini, Matthias; D’Arminio Monforte, Antonella; Casabona, Jordi; Hogg, Robert S; Mocroft, Amanda; Lampe, Fiona C; Dabis, François; Fätkenheuer, Gerd; Sterling, Timothy R; del Amo, Julia; Gill, M John; Crane, Heidi M; Saag, Michael S; Guest, Jodie; Brodt, Hans-Reinhard; Sterne, Jonathan AC

    2014-01-01

    The advent of effective combination antiretroviral therapy (ART) in 1996 resulted in fewer patients experiencing clinical events, so that some prognostic analyses of individual cohort studies of human immunodeficiency virus-infected individuals had low statistical power. Because of this, the Antiretroviral Therapy Cohort Collaboration (ART-CC) of HIV cohort studies in Europe and North America was established in 2000, with the aim of studying the prognosis for clinical events in acquired immune deficiency syndrome (AIDS) and the mortality of adult patients treated for HIV-1 infection. In 2002, the ART-CC collected data on more than 12,000 patients in 13 cohorts who had begun combination ART between 1995 and 2001. Subsequent updates took place in 2004, 2006, 2008, and 2010. The ART-CC data base now includes data on more than 70 000 patients participating in 19 cohorts who began treatment before the end of 2009. Data are collected on patient demographics (e.g. sex, age, assumed transmission group, race/ethnicity, geographical origin), HIV biomarkers (e.g. CD4 cell count, plasma viral load of HIV-1), ART regimen, dates and types of AIDS events, and dates and causes of death. In recent years, additional data on co-infections such as hepatitis C; risk factors such as smoking, alcohol and drug use; non-HIV biomarkers such as haemoglobin and liver enzymes; and adherence to ART have been collected whenever available. The data remain the property of the contributing cohorts, whose representatives manage the ART-CC via the steering committee of the Collaboration. External collaboration is welcomed. Details of contacts are given on the ART-CC website (www.art-cohort-collaboration.org). PMID:23599235

  7. Investigation of RADTRAN Stop Model input parameters for truck stops

    International Nuclear Information System (INIS)

    Griego, N.R.; Smith, J.D.; Neuhauser, K.S.

    1996-01-01

    RADTRAN is a computer code for estimating the risks and consequences as transport of radioactive materials (RAM). RADTRAN was developed and is maintained by Sandia National Laboratories for the US Department of Energy (DOE). For incident-free transportation, the dose to persons exposed while the shipment is stopped is frequently a major percentage of the overall dose. This dose is referred to as Stop Dose and is calculated by the Stop Model. Because stop dose is a significant portion of the overall dose associated with RAM transport, the values used as input for the Stop Model are important. Therefore, an investigation of typical values for RADTRAN Stop Parameters for truck stops was performed. The resulting data from these investigations were analyzed to provide mean values, standard deviations, and histograms. Hence, the mean values can be used when an analyst does not have a basis for selecting other input values for the Stop Model. In addition, the histograms and their characteristics can be used to guide statistical sampling techniques to measure sensitivity of the RADTRAN calculated Stop Dose to the uncertainties in the stop model input parameters. This paper discusses the details and presents the results of the investigation of stop model input parameters at truck stops

  8. Optimally Stopped Optimization

    Science.gov (United States)

    Vinci, Walter; Lidar, Daniel

    We combine the fields of heuristic optimization and optimal stopping. We propose a strategy for benchmarking randomized optimization algorithms that minimizes the expected total cost for obtaining a good solution with an optimal number of calls to the solver. To do so, rather than letting the objective function alone define a cost to be minimized, we introduce a further cost-per-call of the algorithm. We show that this problem can be formulated using optimal stopping theory. The expected cost is a flexible figure of merit for benchmarking probabilistic solvers that can be computed when the optimal solution is not known, and that avoids the biases and arbitrariness that affect other measures. The optimal stopping formulation of benchmarking directly leads to a real-time, optimal-utilization strategy for probabilistic optimizers with practical impact. We apply our formulation to benchmark the performance of a D-Wave 2X quantum annealer and the HFS solver, a specialized classical heuristic algorithm designed for low tree-width graphs. On a set of frustrated-loop instances with planted solutions defined on up to N = 1098 variables, the D-Wave device is between one to two orders of magnitude faster than the HFS solver.

  9. How Can I Stop Cutting?

    Science.gov (United States)

    ... Educators Search English Español How Can I Stop Cutting? KidsHealth / For Teens / How Can I Stop Cutting? ... in a soft, cozy blanket Substitutes for the Cutting Sensation You'll notice that all the tips ...

  10. InDesign CC digital classroom

    CERN Document Server

    Smith, Christopher

    2013-01-01

    Learn the newest version of Adobe's premiere page design software-InDesign CC- with this complete package Written by a team of expert instructors, this complete book-and-DVD package teaches even the most inexperienced beginner how to design eye-popping layouts for brochures, magazines, e-books, and flyers. Step-by-step instructions in the full-color book are enhanced by video tutorials on the companion DVD. Thirteen self-paced lessons let you learn Adobe InDesign CC (Creative Cloud) at your own speed; it's like having your own personal tutor teaching you the hottest new version of this leadi

  11. Adobe Edge Animate CC for dummies

    CERN Document Server

    Rohde, Michael

    2013-01-01

    The easy way to build HTML5 mobile and web apps using Adobe's new Edge Animate CC Edge Animate CC is an approachable WYSIWYG alternative for leveraging the power of languages like HTML5, CSS3, and JavaScript to design and develop for the web and mobile devices, even if you have no programming experience. Written by Michael Rohde, the book calls on this seasoned web developer's wealth of experience using Edge Animate CC, and a companion website includes all code from the book to help you apply what you learn as you go. Features an easy-to-use interface, with a propert

  12. Global spread of mouse-adapted Staphylococcus aureus lineages CC1, CC15, and CC88 among mouse breeding facilities.

    Science.gov (United States)

    Mrochen, Daniel M; Grumann, Dorothee; Schulz, Daniel; Gumz, Janine; Trübe, Patricia; Pritchett-Corning, Kathleen; Johnson, Sarah; Nicklas, Werner; Kirsch, Petra; Martelet, Karine; Brandt, Jens van den; Berg, Sabine; Bröker, Barbara M; Wiles, Siouxsie; Holtfreter, Silva

    2017-11-20

    We previously reported that laboratory mice from all global vendors are frequently colonized with Staphylococcus aureus (S. aureus). Genotyping of a snap sample of murine S. aureus isolates from Charles River, US, showed that mice were predominantly colonized with methicillin-sensitive CC88 strains. Here, we expanded our view and investigated whether laboratory mice from other global animal facilities are colonized with similar strains or novel S. aureus lineages, and whether the murine S. aureus isolates show features of host adaptation. In total, we genotyped 230 S. aureus isolates from various vendor facilities of laboratory mice around the globe (Charles River facilities in the USA, Canada, France, and Germany; another US facility) and university- or company-associated breeding facilities in Germany, China and New Zealand. Spa typing was performed to analyse the clonal relationship of the isolates. Moreover, multiplex PCRs were performed for human-specific virulence factors, the immune-evasion cluster (IEC) and superantigen genes (SAg). We found a total of 58 different spa types that clustered into 15 clonal complexes (CCs). Three of these S. aureus lineages had spread globally among laboratory mice and accounted for three quarters of the isolates: CC1 (13.5%), CC15 (14.3%), and CC88 (47.0%). Compared to human colonizing isolates of the same lineages, the murine isolates frequently lacked IEC genes and SAg genes on mobile genetic elements, implying long-term adaptation to the murine host. In conclusion, laboratory mice from various vendors are colonized with host-adapted S. aureus-strains of a few lineages, predominantly the CC88 lineage. S. aureus researchers must be cautioned that S. aureus colonization might be a relevant confounder in infection and vaccination studies and are therefore advised to screen their mice before experimentation. Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved.

  13. Retroactive Stop Loss Special Pay

    Science.gov (United States)

    Pay (RSLSP), providing $500 for each month/partial month served in stop loss status. Service members served under stop loss must submit a claim for the special pay. Throughout the year, the services have or extension of service, became ineligible to receive retroactive stop loss special pay. There may be

  14. Electron stopping powers for transport calculations

    International Nuclear Information System (INIS)

    Berger, M.J.

    1988-01-01

    The reliability of radiation transport calculations depends on the accuracy of the input cross sections. Therefore, it is essential to review and update the cross sections from time to time. Even though the main interest of the author's group at NBS is in transport calculations and their applications, the group spends almost as much time on the analysis and preparation of cross sections as on the development of transport codes. Stopping powers, photon attenuation coefficients, bremsstrahlung cross sections, and elastic-scattering cross sections in recent years have claimed attention. This chapter deals with electron stopping powers (with emphasis on collision stopping powers), and reviews the state of the art as reflected by Report 37 of the International Commission on Radiation Units and Measurements

  15. Dynamical analysis of critical assembly CC-1

    International Nuclear Information System (INIS)

    Aleman Fernandez, J.R.

    1990-01-01

    The computer code CC-1, elaborated for the analysis of transients in Critical Assemblies is described. The results by the program are compared with the ones presented in the Safety Report for the Critical Assembly of ''La Quebrada'' Nuclear Research Centre (CIN). 7 refs

  16. Book Review: Stop, Write!

    Directory of Open Access Journals (Sweden)

    Hans Thulesius

    2013-06-01

    Full Text Available This book on writing grounded theory is intended for the empirical GT researcher who wants to pursue his/her research until publication. It is the first book devoted entirely to such a crucial issue as writing grounded theory. Thus, Stop, Write: Writing Grounded Theory, is a practical book that fills a gap in GT methodology. In the first chapter of the book, Dr. Glaser says, “Stop unending conceptualization, unending data coverage, and unending listening to others who would egg you on with additional data, ideas and/or requirements or simply wait too long”. The book teaches the reader how to actually write a grounded theory by “simply” writing up the sorted memos. This requires efficient sorting that is dealt with in chapter two on Sorting Memos, which includes precious repetition from Theoretical Sensitivity (1978. How writing can be done effectively is outlined in chapter three The Working Paper. Then follows chapter four on how to rework the first draft with the different tasks of editing for language and professionalism. Thereafter Dr. Glaser discusses Writing Problems in chapter five where he gives useful guidance on how to overcome writing blocks and problems with supervisors and dissertation committees. The book also deals with publishing and with collaboration as experienced between Barney Glaser and the cofounder of grounded theory, Anselm Strauss.

  17. GMSB with Light Stops

    CERN Document Server

    Delgado, Antonio; Quiros, Mariano

    2015-01-01

    Gauge mediated supersymmetry breaking (GMSB) is an elegant mechanism to transmit supersymmetry breaking from the hidden to the MSSM observable sector, which solves the supersymmetric flavor problem. However the smallness of the generated stop mixing requires superheavy stops to reproduce the experimental value of the Higgs mass. Two possible ways out are: i) To extend GMSB by direct superpotential messenger-MSSM Yukawa couplings to generate sizeable mixing, thus reintroducing the flavor problem; ii) To extend the MSSM Higgs sector with singlets and/or triplets providing extra tree-level corrections to the Higgs mass. Singlets will not get any soft mass from GMSB and triplets will contribute to the $\\rho$ parameter which could be an issue. In this paper we explore the second way by introducing extra supersymmetric triplets with hypercharges $Y=(0,\\pm 1)$, with a tree-level custodial $SU(2)_L\\otimes SU(2)_R$ global symmetry in the Higgs sector protecting the $\\rho$ parameter: a supersymmetric generalization of ...

  18. PENGARUH KELOMPOK REFERENSI TERHADAP KEPUTUSAN PEMBELIAN KAWASAKI NINJA 250 CC

    OpenAIRE

    Kartika WB, Sylvia; Sidig, Rosyid

    2018-01-01

    The purpose of this study is to examine the affect of reference groups  on purchasing decision of  Kawasaki Ninja 250 cc in the city of Jambi. Size of sample consist of 100 unit that chousen randomly. While data analysis used  multiple regression analysis. The results showed that simultaneouly   normative, value expression, and  informative have significant role. But, based on partiall test  normative has no significant affect. Hence,  reference group h...

  19. One-Stop Dispensing

    DEFF Research Database (Denmark)

    Houlind, Morten Baltzer; McNulty, Helle Bach Ølgaard; Treldal, Charlotte

    2018-01-01

    (1) Objective: To assess hospital medication costs and staff time between One-Stop Dispensing (OSD) and the Traditional Medication System (TMS), and to evaluate patient perspectives on OSD. (2) Methods: The study was conducted at Hvidovre Hospital, University of Copenhagen, Denmark in an elective...... gastric surgery and acute orthopedic surgery department. This study consists of three sub-studies including adult patients able to self-manage medication. In Sub-study 1, staff time used to dispense and administer medication in TMS was assessed. Medication cost and OSD staff time were collected in Sub......-study 2, while patient perspectives were assessed in Sub-study 3. Medication costs with two days of discharge medication were compared between measured OSD cost and simulated TMS cost for the same patients. Measured staff time in OSD was compared to simulated staff time in TMS for the same patients...

  20. Current stopping power analyses

    International Nuclear Information System (INIS)

    Porter, L.E.

    1983-01-01

    Modified Bethe-Bloch stopping power theory permits fairly accurate calculation of energy losses over a broad interval of projectile velocity v = νc insofar as several parameters appearing in the revised Bethe-Bloch formula have been corectly evaluated. Since the parameters cannot in general be ascertained by calculation from first principles, fits of theory to measurement remain the best method of evaluation. The parameters alluded to are: the target mean excitation energy; the shell correction scaling parameters; the composite single free parameter of the Barkas (projectile-z 3 ) effect correction formalism, and the strength of the correction term; the high velocity density effect correction parameter; and the low velocity charge state parameter. These parameters are discussed

  1. Incorporating User-oriented Security into CC

    DEFF Research Database (Denmark)

    Sharp, Robin

    2009-01-01

    Current versions of the Common Criteria concentrate very heavily on technical security issues which are relevant for the design of secure systems. This approach largely ignores a number of questions which can have great significance for whether or not the system can be operated securely in an env...... not currently dealt with in CC. Tentative proposals for extensions to the current classes of SFRs will be made on the basis of the analysis of the case....

  2. Operational Aspects of C/C++ Concurrency

    OpenAIRE

    Podkopaev, Anton; Sergey, Ilya; Nanevski, Aleksandar

    2016-01-01

    In this work, we present a family of operational semantics that gradually approximates the realistic program behaviors in the C/C++11 memory model. Each semantics in our framework is built by elaborating and combining two simple ingredients: viewfronts and operation buffers. Viewfronts allow us to express the spatial aspect of thread interaction, i.e., which values a thread can read, while operation buffers enable manipulation with the temporal execution aspect, i.e., determining the order in...

  3. $\\Xi_{cc}$ decays and properties

    CERN Multimedia

    Traill, Murdo Thomas

    2018-01-01

    The $\\Xi$ particles are baryons contains 2 constituent charm quarks in their structure which are expected to decay to high multi-body final states. The LHCb detector is ideally designed for studies of them due to its excellent particle identification and vertex reconstruction. Its capabilities in this area of physics was firmly demonstrated when LHCb announced the discovery of the first ever doubly charmed baryon, $\\Xi^{++}_{cc}$, in decays of $\\Xi^{++}_{cc} \\to \\Lambda^+K^-\\pi^+\\pi^+$ in 2017. This doubly charmed baryon was observed as a highly significant structure in the $\\Lambda^+_c K^-\\pi^+\\pi^+$ mass spectrum from proton-proton collision data recorded by the LHCb detector in Run2. A yield of 313 $\\pm$ 33 $\\Xi^{++}_{cc}$ candidates is measured and the local significances is in excess of 12 $\\sigma$ in the 13 TeV data. The properties of the peak suggest it is inconsistent with being a strongly decaying state. From the 13 TeV data, the mass is measured to be $3621.40\\pm 0.72(stat.) \\pm 0.27(syst....

  4. Selected CC and CXC chemokines in children with atopic asthma

    Directory of Open Access Journals (Sweden)

    Edyta Machura

    2016-05-01

    Full Text Available Introduction : There are only limited data on CC and CXC chemokines regulation in children with asthma. Aim: We compared the serum profile of selected CC and CXC chemokines in patients with atopic asthma and healthy children. Material and methods : Serum concentration of CC chemokines RANTES, MCP-1, and CXC chemokines IP-10, MIG, IL-8, RANTES was measured using cytometric bead array in 44 children with atopic asthma and 17 healthy subjects. Results: The concentration of RANTES was significantly higher and the MIG level was lower in all children with asthma as compared to their control counterparts. We observed increased RANTES and decreased MIG levels also in patients with stable asthma when compared with children in the control group. The IP-10 concentration was similar between the whole asthma group and healthy controls, while significantly increased levels of this chemokine in acute asthma have been observed when compared to stable asthma. For MCP-1 and IL-8, the serum concentration was similar in all compared groups. The MIG concentration correlated positively with IP-10, IL-8, and CRP levels and negatively with the eosinophil count. A negative correlation between the IP-10 and eosinophil count and a negative correlation between FEV1 and IP-10 were found. Conclusions : An increased serum RANTES level in children with asthma may result in enhancement of Th2 lymphocyte recruitment into the airway. A decreased expression of Th1 chemokine MIG in children with stable asthma may contribute to a diminished antagonizing effect on Th2 cytokine production and hence intensify Th2 predominance. An increased IP-10 level in children during an asthma attack suggest that this chemokine is a serological marker of disease exacerbation.

  5. Rh-Catalyzed decarbonylative coupling with alkynes via C-C activation of isatins.

    Science.gov (United States)

    Zeng, Rong; Dong, Guangbin

    2015-02-04

    Herein we report a [5 + 2 - 1] transformation though catalytic decarbonylative coupling between isatins and alkynes, which provides a unique way to synthesize 2-quinolinone derivatives. A broad range of alkynes can be coupled efficiently with high regioselectivity. This reaction is proposed to go through C-C activation of isatins, followed by decarbonylation and alkyne insertion. Directing group (DG) plays a critical role in this transformation. Assisted by the DG, the C-C cleavage of isatins occurs at room temperature.

  6. Has Human Evolution Stopped?

    Directory of Open Access Journals (Sweden)

    Alan R. Templeton

    2010-07-01

    Full Text Available It has been argued that human evolution has stopped because humans now adapt to their environment via cultural evolution and not biological evolution. However, all organisms adapt to their environment, and humans are no exception. Culture defines much of the human environment, so cultural evolution has actually led to adaptive evolution in humans. Examples are given to illustrate the rapid pace of adaptive evolution in response to cultural innovations. These adaptive responses have important implications for infectious diseases, Mendelian genetic diseases, and systemic diseases in current human populations. Moreover, evolution proceeds by mechanisms other than natural selection. The recent growth in human population size has greatly increased the reservoir of mutational variants in the human gene pool, thereby enhancing the potential for human evolution. The increase in human population size coupled with our increased capacity to move across the globe has induced a rapid and ongoing evolutionary shift in how genetic variation is distributed within and among local human populations. In particular, genetic differences between human populations are rapidly diminishing and individual heterozygosity is increasing, with beneficial health effects. Finally, even when cultural evolution eliminates selection on a trait, the trait can still evolve due to natural selection on other traits. Our traits are not isolated, independent units, but rather are integrated into a functional whole, so selection on one trait can cause evolution to occur on another trait, sometimes with mildly maladaptive consequences.

  7. UDI STOP Femminicidio

    Directory of Open Access Journals (Sweden)

    Giovanna Crivelli

    2014-04-01

    Full Text Available L'UDI, Unione Donne in Italia, ha collaborato con l'Osservatorio dei Processi Comunicativi a un numero monografico della rivista scientifica M@gm@ dal titolo "Violenza maschile e femminicidio". Il numero monografico vuole mettere a disposizione le analisi, l’esperienza e la storia nostra e delle nostre interlocutrici, come contributo al nostro comune lavoro di sensibilizzazione, contrasto alla violenza maschile sulle donne – femminicidio. “UDI STOP femminicidio” è da anni la nostra campagna contro la violenza di genere, la collaborazione con l’Osservatorio dei Processi Comunicativi è parte integrante di questo sforzo. Il primo e dichiarato dei nostri progetti politici è il contrasto alla cultura e al potere ideologico che consente il femminicidio, la subordinazione culturale e sociale, la percezione della donna come oggetto di dominio, la riduzione in schiavitù di tante donne, comprese molte donne prostitute... Sappiamo di non voler tradire una “responsabilità di genere” che deve necessariamente concretizzarsi in tanti “gesti responsabili”, nella lunga pazienza quotidiana che consente la sedimentazione di un cambiamento radicale nelle coscienze. Vogliamo continuare ad essere l’associazione che coniuga insieme la soggettività personale e l'assunzione diretta di responsabilità, della progettualità a lungo termine che non trova “contraddittorio” misurarsi con la solidarietà concreta e quotidiana con le altre donne, nel tentativo di far nascere le nuove maniere di pensare.

  8. Possible Existence of (cc¯)–Nucleus Bound States

    International Nuclear Information System (INIS)

    Yokota, Akira; Oka, Makoto; Hiyama, Emiko

    2014-01-01

    Charmonium (cc¯) bound states in few-nucleon systems, 2 H, 4 He and 8 Be, are studied via Gaussian Expansion Method (GEM). We adopt a Gaussian potential as an effective (cc¯)–nucleon (N) interaction. The relation between two-body (cc¯)–N scattering length a cc¯−N and the binding energies B of (cc¯)–nucleus bound states are given. Recent lattice QCD data of a cc¯−N corresponds to B≃0.5 MeV for (cc¯)− 4 He and 2 MeV for (cc¯)− 8 Be in our results. (author)

  9. Nitrogen Research Programme STOP

    International Nuclear Information System (INIS)

    Erisman, J.W.; Van der Eerden, L.

    2000-01-01

    Nitrogen pollution is one of the main threats to the environment now in the Netherlands as well as other parts of Europe. In order to address the main gaps on the issues of nitrogen pollution related to the local scale, the Ministries of Housing, Physical Planning and Environment (VROM) and of Agriculture, Nature Management and Fisheries (LNV) have initiated a research programme, the Dutch Nitrogen Research Programme (STOP), which aims to provide a scientific basis to develop and implement policy on a local scale for the realisation and conservation of the EHS ('Dutch Mainframe of Natural Landscapes'). The results of the programme show that the description of emissions from manure in the field is difficult to describe and show large uncertainties. On the contrary, emissions from housings could be modelled well, if local actual data were available. The OPS model to describe the dispersion and deposition was evaluated with the measurements and the limitations were quantified. It appears that the model works well on the long term, whereas on the short term (hours) and short distance (tenths of meters) there is large uncertainty, especially in complex terrain. Critical loads for nitrogen for ecosystems were evaluated. Furthermore, the effect of management options was quantified. A method to determine critical loads as a function of soil conditions, such as acidification and water availability was derived. This resulted in a combination of the soil model SMART and the so-called 'nature planner' (Natuurplanner). It was concluded that the combination of SMART, the nature planner and OPS provide a good tool to develop and support policy on the local scale. 4 refs

  10. Basis set effects on coupled cluster benchmarks of electronically excited states: CC3, CCSDR(3) and CC2

    DEFF Research Database (Denmark)

    Silva-Junior, Mario R.; Sauer, Stephan P. A.; Schreiber, Marko

    2010-01-01

    Vertical electronic excitation energies and one-electron properties of 28 medium-sized molecules from a previously proposed benchmark set are revisited using the augmented correlation-consistent triple-zeta aug-cc-pVTZ basis set in CC2, CCSDR(3), and CC3 calculations. The results are compared...... to those obtained previously with the smaller TZVP basis set. For each of the three coupled cluster methods, a correlation coefficient greater than 0.994 is found between the vertical excitation energies computed with the two basis sets. The deviations of the CC2 and CCSDR(3) results from the CC3 reference...... values are very similar for both basis sets, thus confirming previous conclusions on the intrinsic accuracy of CC2 and CCSDR(3). This similarity justifies the use of CC2- or CCSDR(3)-based corrections to account for basis set incompleteness in CC3 studies of vertical excitation energies. For oscillator...

  11. IMPACTS OF BUS STOP IMPROVEMENTS

    Science.gov (United States)

    2018-03-23

    Improving bus stops by providing shelters, seating, signage, and sidewalks is relatively inexpensive and popular among riders and local officials. Making such improvements, however, is not often a priority for U.S. transit providers because of compet...

  12. A whistle-stop tour of statistics

    National Research Council Canada - National Science Library

    Everitt, Brian

    2012-01-01

    "Preface according to my Penguin English dictionary, whistle-stop, used before a noun means 'consisting of brief stops in several places' and this whistle-stop tour of statistics does just that, with...

  13. Sweet Spots and Door Stops

    Science.gov (United States)

    Thompson, Michael; Tsui, Stella; Leung, Chi Fan

    2011-01-01

    A sweet spot is referred to in sport as the perfect place to strike a ball with a racquet or bat. It is the point of contact between bat and ball where maximum results can be produced with minimal effort from the hand of the player. Similar physics can be applied to the less inspiring examples of door stops; the perfect position of a door stop is…

  14. Analysis specifications for the CC3 biosphere model BIOTRAC

    International Nuclear Information System (INIS)

    Szekely, J.G.; Wojciechowski, L.C.; Stephens, M.E.; Halliday, H.A.

    1994-12-01

    AECL Research is assessing a concept for disposing of Canada's nuclear fuel waste in a vault deep in plutonic rock of the Canadian Shield. A computer program called the Systems Variability Analysis Code (SYVAC) has been developed as an analytical tool for the postclosure (long-term) assessment of the concept. SYVAC3, the third generation of the code, is an executive program that directs repeated simulation of the disposal system to take into account parameter variation. For the postclosure assessment, the system model, CC3 (Canadian Concept, generation 3), was developed to describe a hypothetical disposal system that includes a disposal vault, the local geosphere and the biosphere in the vicinity of any discharge zones. BIOTRAC (BIOsphere TRansport And Consequences) is the biosphere model in the CC3 system model. The specifications for BIOTRAC, which were developed over a period of seven years, were subjected to numerous walkthrough examinations by the Biosphere Model Working Group to ensure that the intent of the model developers would be correctly specified for transformation into FORTRAN code. The FORTRAN version of BIOTRAC was written from interim versions of these specifications. Improvements to the code are based on revised versions of these specifications. The specifications consist of a data dictionary; sets of synopses, data flow diagrams and mini specs for the component models of BIOTRAC (surface water, soil, atmosphere, and food chain and dose); and supporting calculations (interface to the geosphere, consequences, and mass balance). (author). 20 refs., tabs., figs

  15. Probing Light Stops with Stoponium

    CERN Document Server

    Batell, Brian

    2015-01-01

    We derive new limits on light stops from diboson resonance searches in the $\\gamma\\gamma$, $Z \\gamma$, $ZZ$, $WW$ and $hh$ channels from the first run of the LHC. If the two-body decays of the light stop are mildly suppressed or kinematically forbidden, stoponium bound states will form in $pp$ collisions and subsequently decay via the pair annihilation of the constituent stops to diboson final states, yielding striking resonance signatures. Remarkably, we find that stoponium searches are highly complementary to direct collider searches and indirect probes of light stops such as Higgs coupling measurements. Using an empirical quarkonia potential model and including the first two $S$-wave stoponium states, we find that in the decoupling limit $m_{\\widetilde t_1} \\lesssim 130$ GeV is excluded for any value of the stop mixing angle and heavy stop mass by the combination of the latest resonance searches and the indirect constraints. The $\\gamma \\gamma$ searches are the most complementary to the indirect constraint...

  16. Overriding actions in Parkinson’s disease : Impaired stopping and changing of motor responses

    NARCIS (Netherlands)

    van den Wildenberg, W.P.M.; Ridderinkhof, K.R.; van Wouwe, N.C.; Neimat, J.S.; Bashore, T.R.; Wylie, S.A.

    2017-01-01

    We administered a stop-change paradigm, an extended version of the stop task that requires (a) stopping an ongoing motor response and (b) changing to an alternative (change) response. Performance of a group of patients diagnosed with Parkinson's disease (PD) and taking dopaminergic medication was

  17. Second stop and sbottom searches with a stealth stop

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Hsin-Chia; Li, Lingfeng; Qin, Qin [Department of Physics, University of California,Davis, California 95616 (United States)

    2016-11-29

    The top squarks (stops) may be the most wanted particles after the Higgs boson discovery. The searches for the lightest stop have put strong constraints on its mass. However, there is still a search gap in the low mass region if the spectrum of the stop and the lightest neutralino is compressed. In that case, it may be easier to look for the second stop since naturalness requires both stops to be close to the weak scale. The current experimental searches for the second stop are based on the simplified model approach with the decay modes t̃{sub 2}→t̃{sub 1}Z and t̃{sub 2}→t̃{sub 1}h. However, in a realistic supersymmetric spectrum there is always a sbottom lighter than the second stop, hence the decay patterns are usually more complicated than the simplified model assumptions. In particular, there are often large branching ratios of the decays t̃{sub 2}→b̃{sub 1}W and b̃{sub 1}→t̃{sub 1}W as long as they are open. The decay chains can be even more complex if there are intermediate states of additional charginos and neutralinos in the decays. By studying several MSSM benchmark models at the 14 TeV LHC, we point out the importance of the multi-W final states in the second stop and the sbottom searches, such as the same-sign dilepton and multilepton signals, aside from the traditional search modes. The observed same-sign dilepton excesses at LHC Run 1 and Run 2 may be explained by some of our benchmark models. We also suggest that the vector boson tagging and a new kinematic variable may help to suppress the backgrounds and increase the signal significance for some search channels. Due to the complex decay patterns and lack of the dominant decay channels, the best reaches likely require a combination of various search channels at the LHC for the second stop and the lightest sbottom.

  18. First North American 50 cc Total Artificial Heart Experience: Conversion from a 70 cc Total Artificial Heart.

    Science.gov (United States)

    Khalpey, Zain; Kazui, Toshinobu; Ferng, Alice S; Connell, Alana; Tran, Phat L; Meyer, Mark; Rawashdeh, Badi; Smith, Richard G; Sweitzer, Nancy K; Friedman, Mark; Lick, Scott; Slepian, Marvin J; Copeland, Jack G

    2016-01-01

    The 70 cc total artificial heart (TAH) has been utilized as bridge to transplant (BTT) for biventricular failure. However, the utilization of 70 cc TAH has been limited to large patients for the low output from the pulmonary as well as systemic vein compression after chest closure. Therefore, the 50 cc TAH was developed by SynCardia (Tucson, AZ) to accommodate smaller chest cavity. We report the first TAH exchange from a 70 to 50 cc due to a fit difficulty. The patient failed to be closed with a 70 cc TAH, although the patient met the conventional 70 cc TAH fit criteria. We successfully closed the chest with a 50 cc TAH.

  19. Influence of H-C bonds on the stopping power of hard and soft carbonized layers

    International Nuclear Information System (INIS)

    Boutard, D.; Moeller, W.; Scherzer, B.M.U.

    1988-01-01

    Soft and hard carbon-hydrogen films were deposited in a rf glow discharge. Their stopping powers were deduced from depth-profile analysis by means of proton enhanced-cross-section scattering at around 1.5 MeV and 4 He + elastic-recoil detection at 2.6 MeV. In the case of soft films, ion-induced hydrogen depletion allowed study of the dependence of the stopping on hydrogen concentration. The presence of hydrogen increases the stopping power of the film by a factor of up to ∼2 compared to the predicted value for pure carbon. Moreover, Bragg's rule underestimates the total stopping considerably. However, good agreement is obtained with a recent theoretical model by Sabin et al. which takes into account the different C-C and C-H s

  20. Stop. Write! Writing Grounded Theory

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, PhD, Hon. PhD

    2012-06-01

    Full Text Available The message in this book, the dictum in this book, is to stop and write when the Grounded Theory (GT methodology puts you in that ready position. Stop unending conceptualization, unending data coverage, and unending listening to others who would egg you on with additional data, ideas and/or requirements or simply wait too long. I will discuss these ideas in detail. My experience with PhD candidates is that for the few who write when ready, many do not and SHOULD. Simply put, many write-up, but many more should.

  1. Could stops lighten the top?

    International Nuclear Information System (INIS)

    Bilal, A.; Ellis, J.; Fogli, G.L.

    1990-01-01

    The analysis of the presently available electroweak data including radiative corrections in the standard model suggests that the top quark weighs more than the Z 0 . We examine whether squark loops in the minimal supersymmetric model, particularly those involving stops (partners of the top quark), could reduce substantially the preferred range of top quark masses. Given the present lower bounds on squark masses, we find that stop effects can reduce the central value of m t by at most a few GeV, although they do make a very heavy top quark increasingly unlikely. (orig.)

  2. Replacement of Neisseria meningitidis C cc11/ET-15 variant by a cc103 hypervirulent clone, Brazil 2005-2011.

    Science.gov (United States)

    Sardinha, Guilherme; Cordeiro, Soraia; Gomes, Erica; Romanelli, Cinthia; Andrade, Claudia; Reis, Joice; de Filippis, Ivano

    2013-08-01

    Outbreaks caused by serogroup C meningococci in the northeast region of Brazil from 2005 to 2011 were associated to the emergence of variant ET-15 of cc11, which has been replaced by cc103 from 2006 to date. The increase of cc103 should be closely monitored to prevent the spread of this clone to neighbouring regions. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Nuclear stopping in transmission experiments

    International Nuclear Information System (INIS)

    Glazov, Lev G.; Sigmund, Peter

    2003-01-01

    Energy-loss spectra, mean and peak energy loss, and straggling due to elastic nuclear scattering have been studied theoretically as a function of target thickness and deflection angle of an initially monochromatic and well-collimated ion beam. The goal of this work has been to provide a generally valid scheme for nuclear-stopping corrections, allowing to determine electronic-stopping forces from energy-loss spectra measured in transmission geometry. Calculations have been based on the generalized Bothe-Landau theory of energy loss and multiple scattering. Our peak energy losses at zero emergence angle show close (∼10%) agreement with predictions of Fastrup et al. on the basis of the Bohr-Williams theory. However, predicted mean and peak energy losses are found to more sensitively depend on the underlying interatomic potential than unrestricted, i.e. angle-integrated mean or peak energy losses. Both elastic energy loss and multiple scattering are known to obey scaling laws involving only two combinations of the pertinent variables and atomic parameters. The dependence on deflection angle and foil thickness of mean and peak energy loss obeys a simple combination of these scaling laws. Comments are made on potential errors due to uncertainties in the nuclear-stopping correction applied in the literature with specific reference to central papers in low-velocity stopping

  4. Stop searches in flavourful supersymmetry

    CERN Document Server

    Crivellin, Andreas; Tunstall, Lewis C.

    2016-01-01

    Natural realisations of supersymmetry require light stops ${\\tilde t}_1$, making them a prime target of LHC searches for physics beyond the Standard Model. Depending on the kinematic region, the main search channels are ${\\tilde t_1}\\to t \\tilde \\chi^0_1$, ${\\tilde t_1}\\to W b \\tilde \\chi^0_1$ and ${\\tilde t_1}\\to c \\tilde \\chi^0_1$. We first examine the interplay of these decay modes with ${\\tilde c_1}\\to c \\tilde \\chi^0_1$ in a model-independent fashion, revealing the existence of large regions in parameter space which are excluded for any ${\\tilde t_1}\\to c \\tilde \\chi^0_1$ branching ratio. This effect is then illustrated for scenarios with stop-scharm mixing in the right-handed sector, where it has previously been observed that the stop mass limits can be significantly weakened for large mixing. Our analysis shows that once the LHC bounds from ${\\tilde c_1}\\to c \\tilde \\chi^0_1$ searches are taken into account, non-zero stop-scharm mixing leads only to a modest increase in the allowed regions of parameter...

  5. Correlated ion stopping in plasmas

    International Nuclear Information System (INIS)

    Zwicknagel, G.; Deutsch, C.

    1997-01-01

    The basic features of correlated ion stopping in plasmas are demonstrated by employing two opposite extremes of cluster structures, a statistical model with a spatial ion distribution of Gaussian shape and the highly regular configuration of N-ion chains and cubic boxes. In the case of the ion chains the resonant character of correlated stopping due to the interference of the excited wake fields is discussed in detail. The general behavior of correlation effects is summarized and its dependence on the ratio of cluster size and interion spacing to the screening length in the plasma, as well as the ratio of the cluster velocity to the mean electron velocity in the target, is stressed out. The validity and applicability of the dielectric response formalism used for describing correlated stopping is critically reviewed. A scheme is presented to extend the linear formalism to weak nonlinear situations that occur, in particular, for small highly charged clusters at moderate or low velocities. For the Gaussian cluster a fit formula is given, which allows a fast and accurate calculation of the enhancement of stopping due to correlation effects and applies for all degrees of degeneracy of the electrons and arbitrary cluster velocities. copyright 1997 The American Physical Society

  6. Remote Shutoff Stops Runaway Lawnmower

    Science.gov (United States)

    Grambo, Alan A.

    2007-01-01

    In this article, the author describes how electronics students at Central Nine Career Center designed a kill switch circuit to stop a runaway lawnmower. This project is ideal for a career center since the electronics/robotics, small engines and horticulture classes can all work together on their respective parts of the modification, installation…

  7. Reparametrizations with given stop data

    DEFF Research Database (Denmark)

    Raussen, Martin

    2009-01-01

    In [1] we performed a systematic investigation of reparametrizations of continuous paths in a Hausdorff space that relies crucially on a proper understanding of stop data of a (weakly increasing) reprametrizations of the unit interval. I am grateful to Marco Grandis (Genova) for pointing out to me...

  8. Reparametrizations with given stop data

    DEFF Research Database (Denmark)

    Raussen, Martin

    In [1], we performed a systematic investigation of reparametrizations of continuous paths in a Hausdorff space that relies crucially on a proper understanding of stop data of a (weakly increasing) reparametrization of the unit interval. I am indebted to Marco Grandis (Genova) for pointing out tome...

  9. Stopping Power for Degenerate Electrons

    Energy Technology Data Exchange (ETDEWEB)

    Singleton, Jr., Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-16

    This is a first attempt at calculating the BPS stopping power with electron degeneracy corrections. Section I establishes some notation and basic facts. Section II outlines the basics of the calculation, and in Section III contains some brief notes on how to proceed with the details of the calculation. The remaining work for the calculation starts with Section III.

  10. Plagiarism: Can It Be Stopped?

    Science.gov (United States)

    Christensen, G. Jay

    2011-01-01

    Plagiarism can be controlled, not stopped. The more appropriate question to ask is: What can be done to encourage students to "cheat" correctly by doing the assignment the way it was intended? Cheating by college students continues to reach epidemic proportions on selected campuses, as witnessed by the recent episode at Central Florida University,…

  11. Stop researching transformational leadership! Now!

    NARCIS (Netherlands)

    L.G. Tummers (Lars)

    2013-01-01

    markdownabstract__Intro__ Researchers all over the world, stop with your research on transformational leadership! Now! This could be the provocative conclusion after reading the recent article of Profs. Daan van Knippenberg and Sim Sitkin in The Academy of Management Annals (2013). These

  12. Stop researching transformational leadership! Now!

    OpenAIRE

    Tummers, Lars

    2013-01-01

    markdownabstract__Intro__ Researchers all over the world, stop with your research on transformational leadership! Now! This could be the provocative conclusion after reading the recent article of Profs. Daan van Knippenberg and Sim Sitkin in The Academy of Management Annals (2013). These leadership professors write about the problems surrounding transformational leadership.

  13. Persisting roughness when deposition stops.

    Science.gov (United States)

    Schwartz, Moshe; Edwards, S F

    2004-12-01

    Useful theories for growth of surfaces under random deposition of material have been developed by several authors. The simplest theory is that introduced by Edwards and Wilkinson (EW), which is linear and soluble. Its nonlinear generalization by Kardar, Parisi, and Zhang (KPZ) resulted in many subsequent studies. Yet both EW and KPZ theories contain an unphysical feature. When deposition of material is stopped, both theories predict that as time tends to infinity, the surface becomes flat. In fact, of course, the final surface is not flat, but simply has no gradients larger than the gradient related to the angle of repose. We modify the EW and KPZ theories to accommodate this feature and study the consequences for the simpler system which is a modification of the EW equation. In spite of the fact that the equation describing the evolution of the surface is not linear, we find that the steady state in the presence of noise is not very different in the long-wavelength limit from that of the linear EW equation. The situation is quite different from that of EW when deposition stops. Initially there is still some rearrangement of the surface, but that stops as everywhere on the surface the gradient is less than that related to the angle of repose. The most interesting feature observed after deposition stops is the emergence of history-dependent steady-state distributions.

  14. Tourette Syndrome: Help Stop Bullying

    Science.gov (United States)

    ... work on Tourette Syndrome Tourette Association information on bullying What it’s like to have Tourette – Mary tells her story What children wish people knew about Tourette Syndrome CDC Children’s Mental Health StopBullying.gov Features Media Sign up for Features ...

  15. An NMR study of the covalent and noncovalent interactions of CC-1065 and DNA

    International Nuclear Information System (INIS)

    Scahill, T.A.; Jensen, R.M.; Swenson, D.H.; Hatzenbuhler, N.T.; Petzold, G.; Wierenga, W.; Brahme, N.D.

    1990-01-01

    The binding of the antitumor drug CC-1065 has been studied with nuclear magnetic resonance (NMR) spectroscopy. This study involves two parts, the elucidation of the covalent binding site of the drug to DNA and a detailed investigation of the noncovalent interactions of CC-1065 with a DNA fragment through analysis of 2D NOE (NOESY) experiments. A CC-1065-DNA adduct was prepared, and an adenine adduct was released upon heating. NMR ( 1 H and 13 C) analysis of the adduct shows that the drug binds to N3 of adenine by reaction of its cyclopropyl group. The reaction pathway and product formed were determined by analysis of the 13 C DEPT spectra. An octamer duplex, d(CGATTAGC·GCTAATCG), was synthesized and used in the interaction study of CC-1065 and the oligomer. The duplex and the drug-octamer complex were both analyzed by 2D spectroscopy (COSY, NOESY). The relative intensity of the NOEs observed between the drug (CC-1065) and the octamer duplex shows conclusively that the drug is located in the minor groove, covalently attached to N3 of adenine 6 and positioned from the 3' → 5' end in relation to strand A [d(CGATTA 6 GC)]. A mechanism for drug binding and stabilization can be inferred from the NOE data and model-building studies

  16. Repression of CC16 by cigarette smoke (CS exposure.

    Directory of Open Access Journals (Sweden)

    Lingxiang Zhu

    Full Text Available Club (Clara Cell Secretory Protein (CCSP, or CC16 is produced mainly by non-ciliated airway epithelial cells including bronchiolar club cells and the change of its expression has been shown to associate with the progress and severity of Chronic Obstructive Pulmonary Disease (COPD. In an animal model, the lack of CC16 renders the animal susceptible to the tumorigenic effect of a major CS carcinogen. A recent population-based Tucson Epidemiological Study of Airway Obstructive Diseases (TESAOD has indicated that the low serum CC16 concentration is closely linked with the smoke-related mortality, particularly that driven by the lung cancer. However, the study of CC16 expression in well-defined smoke exposure models has been lacking, and there is no experimental support for the potential causal link between CC16 and CS-induced pathophysiological changes in the lung. In the present study, we have found that airway CC16 expression was significantly repressed in COPD patients, in monkey CS exposure model, and in CS-induced mouse model of COPD. Additionally, the lack of CC16 exacerbated airway inflammation and alveolar loss in the mouse model. Therefore, CC16 may play an important protective role in CS-related diseases.

  17. On plasma coupling and turbulence effects in low velocity stopping

    Energy Technology Data Exchange (ETDEWEB)

    Kurilenkov, Yu K [Unified Institute for High Temperatures of Russian Academy of Sciences, 13/19 Izhorskaya Str., 125412 Moscow (Russian Federation); Maynard, G [Laboratoire de Physique des Gaz et des Plasmas, UMR-8578, Bat. 210, Universite Paris XI, F-91405 Orsay (France); Barriga-Carrasco, M D [Laboratoire de Physique des Gaz et des Plasmas, UMR-8578, Bat. 210, Universite Paris XI, F-91405 Orsay (France); Valuev, A A [Unified Institute for High Temperatures of Russian Academy of Sciences, 13/19 Izhorskaya Str., 125412 Moscow (Russian Federation)

    2006-04-28

    The problem of stopping power (SP) for projectile ions is analysed in terms of the dielectric function and effective collision frequency for moderately dense and strongly coupled plasmas (SCP). We consider several issues regarding the calculation of stopping power for correlated ensembles of particles and oscillators. In particular, effects of group (few particle) modes, transition from positive to negative dispersion and excitation of collective modes up to suprathermal level at plasma targets are addressed. Linear SP of dense suprathermal (nonlinear) plasma targets at different levels of target plasma turbulence is estimated. The force of suprathermal plasma oscillations on the projectile ions is mostly in the nature of increased frictional drag. The results obtained show the possibility of increasing low velocity stopping (up to 'turbulent' values) in comparison with losses in equilibrium dense plasma targets. Experimental conditions to create specific turbulent targets as well as some connection between stopping phenomena and SCP transport properties are discussed briefly.

  18. On plasma coupling and turbulence effects in low velocity stopping

    International Nuclear Information System (INIS)

    Kurilenkov, Yu K; Maynard, G; Barriga-Carrasco, M D; Valuev, A A

    2006-01-01

    The problem of stopping power (SP) for projectile ions is analysed in terms of the dielectric function and effective collision frequency for moderately dense and strongly coupled plasmas (SCP). We consider several issues regarding the calculation of stopping power for correlated ensembles of particles and oscillators. In particular, effects of group (few particle) modes, transition from positive to negative dispersion and excitation of collective modes up to suprathermal level at plasma targets are addressed. Linear SP of dense suprathermal (nonlinear) plasma targets at different levels of target plasma turbulence is estimated. The force of suprathermal plasma oscillations on the projectile ions is mostly in the nature of increased frictional drag. The results obtained show the possibility of increasing low velocity stopping (up to 'turbulent' values) in comparison with losses in equilibrium dense plasma targets. Experimental conditions to create specific turbulent targets as well as some connection between stopping phenomena and SCP transport properties are discussed briefly

  19. Radiological diagnosis and intervention of cholangiocarcinomas (CC); Radiologische Diagnostik und Intervention von Cholangiokarzinomen (CC)

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, T.J.; Zangos, S.; Eichler, K.; Gruber-Rouh, T.; Hammerstingl, R.M.; Weisser, P. [Frankfurt Univ. (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Trojan, J. [Frankfurt Univ. (Germany). Medizinische Klinik I: Gastroenterologie, Endokrinologie, Pneumologie/Allergologie

    2012-10-15

    To present current data on diagnosis, indication and different therapy options in patients with cholangiocarcinoma (CC) based on an analysis of the current literature and clinical experience. The diagnostic routine includes laboratory investigations with parameters of cholestasis and also serum tumor markers CA19 - 9 and CEA. After ultrasound for clarifying a tumor and/or dilated bile ducts, contrast-enhanced magnetic resonance imaging (MRI) should be performed with magnetic resonance cholangiography (MRCP). The accuracy (positive predictive value) for diagnosing a CC is 37 - 84 % (depending on the location) for ultrasound, 79 - 94 % for computed tomography (CT), and 95 % for MRI and MRCP. An endoscopic retrograde cholangiography (ERCP) can then be planned, especially if biliary drainage or cytological or histological specimen sampling is intended. A curative approach can be achieved by surgical resection, rarely by liver transplantation. However, many patients are not eligible for surgery. In addition to systemic chemotherapy, locoregional therapies such as transarterial chemoembolization (TACE), hepatic arterial infusion (HAI) - also known as chemoperfusion -, drug eluting beads-therapy (DEB) as well as thermoablative procedures, such as laser-induced thermotherapy (LITT), microwave ablation (MWA) and radiofrequency ablation (RFA) can be provided with a palliative intention.

  20. Commercial biocides induce transfer of prophage Φ13 from human strains of Staphylococcus aureus to livestock CC398

    DEFF Research Database (Denmark)

    Tang, Yuanyue; Nielsen, Lene Nørby; Hvitved, Annemette

    2017-01-01

    if exposure to biocidal products induces phage transfer, and find that during co-culture, Φ13 from strain 8325, belonging to ΦSa3 group, is induced and transferred from a human strain to LA-MRSA CC398 when exposed to sub-lethal concentrations of commercial biocides containing hydrogen peroxide. Integration...... variation in CC398 strains that disrupts the phage attachment site, but not the expression of β-hemolysin. Our results show that hydrogen peroxide present in biocidal products stimulate transfer of ΦSa3 from human to LA-MRSA CC398 strains and that in these strains prophage stability depends...

  1. Progress in understanding heavy-ion stopping

    Energy Technology Data Exchange (ETDEWEB)

    Sigmund, P., E-mail: sigmund@sdu.dk [Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, DK-5230 Odense M (Denmark); Schinner, A. [Institut für Experimentalphysik, Johannes Kepler Universität, A-4040 Linz (Austria)

    2016-09-01

    We report some highlights of our work with heavy-ion stopping in the energy range where Bethe stopping theory breaks down. Main tools are our binary stopping theory (PASS code), the reciprocity principle, and Paul’s data base. Comparisons are made between PASS and three alternative theoretical schemes (CasP, HISTOP and SLPA). In addition to equilibrium stopping we discuss frozen-charge stopping, deviations from linear velocity dependence below the Bragg peak, application of the reciprocity principle in low-velocity stopping, modeling of equilibrium charges, and the significance of the so-called effective charge.

  2. Progress in understanding heavy-ion stopping

    International Nuclear Information System (INIS)

    Sigmund, P.; Schinner, A.

    2016-01-01

    We report some highlights of our work with heavy-ion stopping in the energy range where Bethe stopping theory breaks down. Main tools are our binary stopping theory (PASS code), the reciprocity principle, and Paul’s data base. Comparisons are made between PASS and three alternative theoretical schemes (CasP, HISTOP and SLPA). In addition to equilibrium stopping we discuss frozen-charge stopping, deviations from linear velocity dependence below the Bragg peak, application of the reciprocity principle in low-velocity stopping, modeling of equilibrium charges, and the significance of the so-called effective charge.

  3. A New Characterization of ACC0 and Probabilistic CC0

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Arnsfelt; Koucký, Michal

    2010-01-01

    Barrington, Straubing & Thérien (1990) conjectured that the Boolean And function can not be computed by polynomial size constant depth circuits built from modular counting gates, i.e., by CC0 circuits. In this work we show that the And function can be computed by uniform probabilistic CC0 circuits...... that use only O(log n) random bits. This may be viewed as evidence contrary to the conjecture. As a consequence of our construction we get that all of ACC0 can be computed by probabilistic CC0 circuits that use only O(log n) random bits. Thus, if one were able to derandomize such circuits, one would obtain...... a collapse of circuit classes giving ACC0 = CC0. We present a derandomization of probabilistic CC0 circuits using And and Or gates to obtain ACC0 = And ο Or ο CC0 = Or ο And ο CC0. (And and Or gates of sublinear fan-in suffice in non-uniform setting.) Both these results hold for uniform as well as non...

  4. Energy Materials Coordinating Committee (EMaCC), Fiscal year 1990

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1991-05-31

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further the effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. Four topical subcommittees are established and are continuing their own programs: Structural Ceramics, Electrochemical Technologies, Radioactive Waste Containment, and Superconductivity. In addition, the EMaCC aids in obtaining materialsrelated inputs for both intra- and inter-agency compilations. Membership in the EMaCC is open to any Department organizational unit; participants are appointed by Division or Office Directors. The current active membership is listed on the following four pages. The EMaCC reports to the Director of the Office of Energy Research in his capacity as overseer of the technical programs of the Department. This annual technical report is mandated by the EMaCC terms of reference. This report summarizes EMaCC activities for FY 1990 and describes the materials research programs of various offices and divisions within the Department. The Chairman of EMaCC for FY 1990 was Scott L. Richlen; the Executive Secretary was Dr. Jerry Smith.

  5. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... your fingers and from your nails to your face and mouth. To help you stop biting your ... re inclined to bite may help solve the problem. Try to gradually stop biting your nails: Some ...

  6. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... Mohs AUC MyDermPath+ Psoriasis Patient education resources ... Try to gradually stop biting your nails: Some doctors recommend taking a gradual approach to break the habit. Try to stop biting ...

  7. Human and Swine Hosts Share Vancomycin-Resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 Clonal Clusters Harboring Tn1546 on Indistinguishable Plasmids

    DEFF Research Database (Denmark)

    Freitas, Ana R.; Coque, Teresa M.; Novais, Carla

    2011-01-01

    clonally related Enterococcus faecium clonal complex 5 (CC5) isolates (17 sequence type 6 [ST6], 6 ST5, 5 ST185, 1 ST147, and 1 ST493) were obtained from feces of swine and healthy humans. This collection included isolates widespread among pigs of European Union (EU) countries since the mid-1990s. Each ST...... comprised isolates showing similar pulsed-field gel electrophoresis (PFGE) patterns (≤6 bands difference; >82% similarity). Some CC5 PFGE subtype strains from swine were indistinguishable from hospital vancomycin-resistant enterococci (VRE) causing infections. A truncated variant of Tn1546 (encoding...... resistance to vancomycin) and tcrB (coding for resistance to copper) were consistently located on 150- to 190-kb plasmids (rep(pLG1)). E. faecium CC17 (ST132) isolates from pig manure and two clinical samples showed identical PFGE profiles and contained a 60-kb mosaic plasmid (rep(Inc18) plus rep...

  8. Search for the doubly charmed baryon $\\Xi_{cc}^+$

    CERN Document Server

    Aaij, R; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Cheung, S -F; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D C; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; Davis, A; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Falabella, A; Färber, C; Farinelli, C; Farry, S; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gorbounov, P; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grillo, L; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Kenyon, I R; Ketel, T; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kurek, K; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Lupton, O; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Maratas, J; Marconi, U; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Martynov, A; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNab, A; McNulty, R; McSkelly, B; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mordà, A; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neubert, S; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pescatore, L; Pesen, E; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rachwal, B; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reichert, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Roberts, D A; Rodrigues, A B; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rotondo, M; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, N A; Smith, E; Smith, E; Smith, J; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Sun, L; Sutcliffe, W; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szilard, D; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vagnoni, V; Valenti, G; Vallier, A; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, C; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, Z; Yang, Z; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    A search for the doubly charmed baryon $\\Xi_{cc}^{+}$ in the decay mode $\\Xi_{cc}^{+} \\to \\Lambda_c^+ K^- \\pi^+$ is performed with a data sample, corresponding to an integrated luminosity of 0.65 fb$^{-1}$, of $pp$ collisions recorded at a centre-of-mass energy of 7 TeV. No significant signal is found in the mass range 3300--3800 MeV$/c^2$. Upper limits at the 95\\% confidence level on the ratio of the $\\Xi_{cc}^{+}$ production cross-section times branching fraction to that of the $\\Lambda_c^+$, $R$, are given as a function of the $\\Xi_{cc}^{+}$ mass and lifetime. The largest upper limits range from $R<1.5 \\times 10^{-2}$ for a lifetime of 100 fs to $R<3.9 \\times 10^{-4}$ for a lifetime of 400 fs.

  9. The ModelCC Model-Driven Parser Generator

    Directory of Open Access Journals (Sweden)

    Fernando Berzal

    2015-01-01

    Full Text Available Syntax-directed translation tools require the specification of a language by means of a formal grammar. This grammar must conform to the specific requirements of the parser generator to be used. This grammar is then annotated with semantic actions for the resulting system to perform its desired function. In this paper, we introduce ModelCC, a model-based parser generator that decouples language specification from language processing, avoiding some of the problems caused by grammar-driven parser generators. ModelCC receives a conceptual model as input, along with constraints that annotate it. It is then able to create a parser for the desired textual syntax and the generated parser fully automates the instantiation of the language conceptual model. ModelCC also includes a reference resolution mechanism so that ModelCC is able to instantiate abstract syntax graphs, rather than mere abstract syntax trees.

  10. Search for the doubly charmed baryon Ξcc +

    NARCIS (Netherlands)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Adrover, C.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; Anderlini, L.; Anderson, J.; Andreassen, P.R.; Andrews, J.E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M-O.; Van Beuzekom, Martin; Bien, A.; Bifani, S.; Bird, T.D.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brambach, T.; Van Den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N. H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Callot, O.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch; Cenci, R.; Charles, M.; Charpentier, Ph; Cheung, S-F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coca-Pelaz, A.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Cruz Torres, M.; Cunliffe, S.; Currie, C.R.; D'Ambrosio, C.; David, P.; David, P.; Davis, A.; De Bonis, I.; De Bruyn, K.; De Capua, S.; De Cian, M.; de Miranda, J. M.; Paula, L.E.; da-Silva, W.S.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Dogaru, M.; Donleavy, S.; Dordei, F.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Van Eijk, D.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Falabella, A.; Färber, C.; Farinelli, C.; Farry, S.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fitzpatrick, C.; Fontana, Mark; Fontanelli, F.; Forty, R.; De Aguiar Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garosi, P.; Garra Tico, J.; Garrido, L.; Carvalho-Gaspar, M.; Gauld, Rhorry; Gersabeck, E.; Gersabeck, M.; Gershon, T. J.; Ghez, Ph; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.Q.; Gorbounov, P.; Head-Gordon, Teresa; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hicks, G.E.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Huse, J.T.; Hussain, N.; Hutchcroft, D. E.; Hynds, D.; Iakovenko, V.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jans, E.; Jaton, P.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Kenyon, I. R.; Ketel, T.; Khanji, B.; Kochebina, O.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G. D.; Lai, A.; Lambert, D.M.; Lambert, R. W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Latham, T. E.; Lazzeroni, C.; Le Gac, R.; Van Leerdam, J.; Lees, J. P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Di Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Li Gioi, L.; Liles, M.; Lindner, R.; Linn, S.C.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lopez-March, N.; Lu, H.; Lucchesi, D.; Luisier, J.; Luo, H.; Lupton, O.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Maratas, J.; Marconi, U.; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martín Sánchez, A.; Martinelli-Boneschi, F.; Martinez-Santos, D.; Martins Tostes, D.; Martynov, A.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Maurice, E.; Mazurov, A.; McCarthy, J.; Mcnab, A.; McNulty, R.; McSkelly, B.; Meadows, B. T.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M. N.; Molina Rodriguez, J.; Monteil, S.; Moran-Zenteno, D.; Morawski, P.; Mordà, A.; Morello, M. J.; Mountain, R.; Mous, I.; Muheim, F.; Müller, Karl; Muresan, R.; Muryn, B.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neubert, S.; Neufeld, N.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Nomerotski, A.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Orlandea, M.; Otalora Goicochea, J. M.; Owen, R.P.; Oyanguren, A.; Pal, B. K.; Palano, A.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrick, G. N.; Patrignani, C.; Pavel-Nicorescu, C.; Pazos Alvarez, A.; Pearce, D.A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perez Trigo, E.; Pérez-Calero Yzquierdo, A.; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pesen, E.; Pessina, G.; Petridis, K.; Petrolini, A.; Phan, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Playfer, S.; Plo Casasus, M.; Polci, F.; Polok, G.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, C.A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, Y.W.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redford, S.; Reichert, S.; Reid, M.; dos Reis, A. C.; Ricciardi, S.; Richards, Al.; Rinnert, K.; Rives Molina, V.; Roa Romero, D. A.; Robbe, P.; Roberts, D. A.; Rodrigues, A. B.; Rodrigues, L.E.T.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, van Hapere; Ruiz Valls, P.; Sabatino, G.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schiller, M.; Schindler, R. H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M. H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, O.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, E.; Smith, J; Smith, M.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; de Souza, D.K.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stevenson-Moore, P.; Stoica, S.; Stone, S.; Storaci, B.; Straticiuc, M.; Straumann, U.; Subbiah, V. K.; Sun, L.; Sutcliffe, W.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szilard, D.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Teodorescu, E.; Teubert, F.; Thomas, C.; Thomas, E.; Van Tilburg, J.; Tisserand, V.; Tobin, M. N.; Tolk, S.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, N.T.M.T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ubeda Garcia, M.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; Velthuis, M.J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; Voss, H.; Waldi, R.; Wallace, C.; Wallace, R.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Webber, A. D.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiechczynski, J.; Wiedner, D.; Wiggers, L.; Wilkinson, G.; Williams, M.P.; Williams, M.; Wilson, James F; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.J.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

    2013-01-01

    A search for the doubly charmed baryon Ξcc + in the decay mode Ξcc + → Λc +K-π+ is performed with a data sample, corresponding to an integrated luminosity of 0.65 fb-1, of pp collisions recorded at a centre-of-mass energy of 7TeV. No significant signal is found in the mass range 3300-3800 MeV/c2.

  11. Characterization of Exopolysaccharide Produced by Streptococcus thermophilus CC30

    Directory of Open Access Journals (Sweden)

    Sri Lakshmi Ramya Krishna Kanamarlapudi

    2017-01-01

    Full Text Available An exopolysaccharide (EPS producing strain CC30 was isolated from raw milk and identified as Streptococcus thermophilus with morphological and 16S sequencing analysis. The strain was shown to produce 1.95 g/L of EPS when grown in skim milk lactose medium at 30°C by increasing the viscosity of the medium. The EPS was isolated and purified, and it was shown to consist of glucose and galactose in 1 : 1 ratio, with molecular weights ranging from 58 to 180 kDa. FTIR spectroscopy indicated the EPS to have amide, hydroxyl, and carboxyl groups. Under Atomic Force Microscopy, EPS showed spike-like lumps of EPS. Scanning Electron Microscopy (SEM studies showed that it had irregular lumps with a coarse surface. The EPS displayed pseudoplastic nature. Thermogravimetric analysis (TGA reported a degradation temperature of 110.84°C. The purified EPS exhibited reducing activity, hydrogen peroxide radical scavenging activity, and emulsification activity. The results of the present study indicated that EPS producing Streptococcus thermophilus could serve as a promising candidate for further exploitation in food industry.

  12. Backbone dynamics of the human CC-chemokine eotaxin

    Energy Technology Data Exchange (ETDEWEB)

    Ye Jiqing; Mayer, Kristen L.; Stone, Martin J. [Indiana University, Department of Chemistry (United States)

    1999-10-15

    Eotaxin is a CC chemokine with potent chemoattractant activity towards eosinophils. {sup 15}N NMR relaxation data have been used to characterize the backbone dynamics of recombinant human eotaxin. {sup 15}N longitudinal (R{sub 1}) and transverse (R{sub 2}) auto relaxation rates, heteronuclear {sup 1}H-{sup 15}N steady-state NOEs, and transverse cross-relaxation rates ({eta}{sub xy}) were obtained at 30 deg. C for all resolved backbone secondary amide groups using {sup 1} H-detected two-dimensional NMR experiments. Ratios of transverse auto and cross relaxation rates were used to identify NH groups influenced by slow conformational rearrangement. Relaxation data were fit to the extended model free dynamics formalism, yielding parameters describing axially symmetric molecular rotational diffusion and the internal dynamics of each NH group. The molecular rotational correlation time ({tau}{sub m}) is 5.09{+-}0.02 ns, indicating that eotaxin exists predominantly as a monomer under the conditions of the NMR study. The ratio of diffusion rates about unique and perpendicular axes (D{sub parallel}/D{sub perpendicular}) is 0.81{+-}0.02. Residues with large amplitudes of subnanosecond motion are clustered in the N-terminal region (residues 1-19), the C-terminus (residues 68-73) and the loop connecting the first two {beta}-strands (residues 30-37). N-terminal flexibility appears to be conserved throughout the chemokine family and may have implications for the mechanism of chemokine receptor activation. Residues exhibiting significant dynamics on the microsecond-millisecond time scale are located close to the two conserved disulfide bonds, suggesting that these motions may be coupled to disulfide bond isomerization.

  13. Why does sleep stop migraine?

    Science.gov (United States)

    Bigal, Marcelo E; Hargreaves, Richard J

    2013-10-01

    The relationship between sleep and migraine headaches is complex. Changes in sleep patterns can trigger migraine attacks, and sleep disorders may be associated with increased migraine frequency. Furthermore, migraine patients and their doctors very consistently report that sleep relieves already established migraine attacks. Herein we will try to answer the question, "Why does sleep stop migraine?" Since evidence for this relationship is largely based on empirical clinical observation, we will not provide a clinical review of the association. Instead, we will focus on the pathophysiology of migraine attacks and its intersections with sleep biology.

  14. Optimal Stopping with Information Constraint

    International Nuclear Information System (INIS)

    Lempa, Jukka

    2012-01-01

    We study the optimal stopping problem proposed by Dupuis and Wang (Adv. Appl. Probab. 34:141–157, 2002). In this maximization problem of the expected present value of the exercise payoff, the underlying dynamics follow a linear diffusion. The decision maker is not allowed to stop at any time she chooses but rather on the jump times of an independent Poisson process. Dupuis and Wang (Adv. Appl. Probab. 34:141–157, 2002), solve this problem in the case where the underlying is a geometric Brownian motion and the payoff function is of American call option type. In the current study, we propose a mild set of conditions (covering the setup of Dupuis and Wang in Adv. Appl. Probab. 34:141–157, 2002) on both the underlying and the payoff and build and use a Markovian apparatus based on the Bellman principle of optimality to solve the problem under these conditions. We also discuss the interpretation of this model as optimal timing of an irreversible investment decision under an exogenous information constraint.

  15. Stopping powers of energetic electrons penetrating condensed matter-theory and application

    International Nuclear Information System (INIS)

    Tan Zhenyu; Xia Yueyuan

    2004-01-01

    In this review article, the motivation of studying inelastic energy loss for energetic electrons penetrating through matter and the corresponding technological importance have been outlined. The theoretical development and method for the calculation of stopping powers are described. The stopping power data tables for a group of polymers and bioorganic compounds are presented, and the application aspects of the stopping power data are briefly discussed. (authors)

  16. Optimally stopped variational quantum algorithms

    Science.gov (United States)

    Vinci, Walter; Shabani, Alireza

    2018-04-01

    Quantum processors promise a paradigm shift in high-performance computing which needs to be assessed by accurate benchmarking measures. In this article, we introduce a benchmark for the variational quantum algorithm (VQA), recently proposed as a heuristic algorithm for small-scale quantum processors. In VQA, a classical optimization algorithm guides the processor's quantum dynamics to yield the best solution for a given problem. A complete assessment of the scalability and competitiveness of VQA should take into account both the quality and the time of dynamics optimization. The method of optimal stopping, employed here, provides such an assessment by explicitly including time as a cost factor. Here, we showcase this measure for benchmarking VQA as a solver for some quadratic unconstrained binary optimization. Moreover, we show that a better choice for the cost function of the classical routine can significantly improve the performance of the VQA algorithm and even improve its scaling properties.

  17. How to stop global warming

    International Nuclear Information System (INIS)

    Goldenberg, J.

    1990-01-01

    This paper reports on how to stop global warming. At the Toronto Conference on Climate Change in 1988, the world's industrialized nations agreed on a goal of cutting greenhouse gas emissions 20 percent by the year 2005. This would not stabilize atmospheric levels of greenhouse gases but would at least slow their accumulation. Although difficult to achieve, the Toronto goal is certainly reachable. Newer, more efficient technologies can lower energy consumption without effecting economic output. CFC- substitutes can provide refrigeration. In fact, an international carbon tax of just $1 per barrel of oil, or $6 per ton of coal, would generate more than enough revenue to pay for the necessary fuel-saving measures. This tax could result from an international agreement similar to the 1987 Montreal Protocol, which obliges its signatories to cut down on production of CFCs

  18. [Characterization and transcriptional analysis of a new CC chemokine associated with innate imimune response in cobia (Rachycentron canadum)].

    Science.gov (United States)

    Su, Y; Feng, J; Sun, X; Guo, Z; Xu, L; Jiang, J

    2013-01-01

    Chemokines are small, secreted cytokine peptides, known principally for their ability to induce migration and activation of leukocyte populations under both pathological and physiological conditions. On the basis of previously constructed express sequence tags (ESTs) of the head kidney and spleen cDNA library of the perciform marine fish Rachycentron canadum (common name cobia). We used bi-directional rapid amplification of cDNA ends (RACE) and obtained a full-length cDNA of a new CC chemokine gene (designated RcCC3). The RcCC3 putative peptide exhibits sequence similarity to the group of CCL19/21/25 CC chemokines. The reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used in transcript expression studies of RcCC3. We examined the constitutive expression of the transcripts in 12 tissues of non-stressed cobia; RcCC3 transcripts were detected in all tissues examined, with the highest expression in gill and liver, following by head kidney, kidney, spleen, skin, intestine, muscle, stomach, heart, blood and brain. Transcript expression of RcCC3 was examined in immune-related organs, including head kidney, spleen and liver, following intraperitoneal injection of phosphate-buffered saline control, polyriboinosinic polyribocytidylic acid (poly(I:C)) and formalin-killed Vibrio carchariae (bacterial vaccine). The transcripts in these tissues were quickly up-regulated by the injection of poly(I:C) and bacterial vaccine at early time points, although with different expression profiles. These results indicate RcCC3 represents an important component of innate immunity in cobia.

  19. Association of serum Clara cell protein CC16 with respiratory infections and immune response to respiratory pathogens in elite athletes.

    Science.gov (United States)

    Kurowski, Marcin; Jurczyk, Janusz; Jarzębska, Marzanna; Moskwa, Sylwia; Makowska, Joanna S; Krysztofiak, Hubert; Kowalski, Marek L

    2014-04-15

    Respiratory epithelium integrity impairment caused by intensive exercise may lead to exercise-induced bronchoconstriction. Clara cell protein (CC16) has anti-inflammatory properties and its serum level reflects changes in epithelium integrity and airway inflammation. This study aimed to investigate serum CC16 in elite athletes and to seek associations of CC16 with asthma or allergy, respiratory tract infections (RTIs) and immune response to respiratory pathogens. The study was performed in 203 Olympic athletes. Control groups comprised 53 healthy subjects and 49 mild allergic asthmatics. Serum levels of CC16 and IgG against respiratory viruses and Mycoplasma pneumoniae were assessed. Allergy questionnaire for athletes was used to determine symptoms and exercise pattern. Current versions of ARIA and GINA guidelines were used when diagnosing allergic rhinitis and asthma, respectively. Asthma was diagnosed in 13.3% athletes, of whom 55.6% had concomitant allergic rhinitis. Allergic rhinitis without asthma was diagnosed in 14.8% of athletes. Mean CC16 concentration was significantly lower in athletes versus healthy controls and mild asthmatics. Athletes reporting frequent RTIs had significantly lower serum CC16 and the risk of frequent RTIs was more than 2-fold higher in athletes with low serum CC16 (defined as equal to or less than 4.99 ng/ml). Athletes had significantly higher anti-adenovirus IgG than healthy controls while only non-atopic athletes had anti-parainfluenza virus IgG significantly lower than controls. In all athletes weak correlation of serum CC16 and anti-parainfluenza virus IgG was present (R = 0.20, p athletes a weak positive correlations of CC16 with IgG specific for respiratory syncytial virus (R = 0.29, p = 0.009), parainfluenza virus (R = 0.31, p = 0.01) and adenovirus (R = 0.27, p = 0.02) were seen as well. Regular high-load exercise is associated with decrease in serum CC16 levels. Athletes with decreased CC16 are

  20. HfC plasma coating of C/C composites

    International Nuclear Information System (INIS)

    Boncoeur, M.; Schnedecker, G.; Lulewicz, J.D.

    1992-01-01

    The surface properties of C/C composites such as hardness and corrosion or erosion resistance can be modified by a ceramic coating applied by plasma torch. The technique of plasma spraying in controlled temperature and atmosphere, that was developed and patented by the CEA, makes it possible to apply coatings to the majority of metals and ceramics without affecting the characteristics of the composite. An example of hard deposit of HfC on a C/C composite is described. The characteristics of the deposit and of the bonding with the C/C composite were studied before and after a heat treatment under vacuum for 2 hours at 1000 C. 2 refs

  1. Are Stopped Strings Preferred in Sad Music?

    OpenAIRE

    David Huron; Caitlyn Trevor

    2017-01-01

    String instruments may be played either with open strings (where the string vibrates between the bridge and a hard wooden nut) or with stopped strings (where the string vibrates between the bridge and a performer's finger pressed against the fingerboard). Compared with open strings, stopped strings permit the use of vibrato and exhibit a darker timbre. Inspired by research on the timbre of sad speech, we test whether there is a tendency to use stopped strings in nominally sad music. Specifica...

  2. Efficient C/C++ programming smaller, faster, better

    CERN Document Server

    Heller, Steve

    1994-01-01

    Efficient C/C++ Programming describes a practical, real-world approach to efficient C/C++ programming. Topics covered range from how to save storage using a restricted character set and how to speed up access to records by employing hash coding and caching. A selective mailing list system is used to illustrate rapid access to and rearrangement of information selected by criteria specified at runtime.Comprised of eight chapters, this book begins by discussing factors to consider when deciding whether a program needs optimization. In the next chapter, a supermarket price lookup system is used to

  3. Measurement of stopping power of heavy ions

    International Nuclear Information System (INIS)

    Kitahara, Tetsuo

    1981-01-01

    The stopping power of heavy ions is discussed. In the low energy region, heavy ions keep some of their orbital electrons, and have equilibrium electron charge. The stopping power of penetrating particles depends on this effective charge. At present, it is hard to estimate this effective charge theoretically, accordingly, the estimation is made experimentally. Another difficulty in this estimation is that the Born approximation is not effective for heavy ions. In the low energy region, electronic stopping and nuclear stopping contribute to the stopping power. For the electronic stopping, a formula for the stopping power was given by Lindhard et al. The experimental values were obtained at GSI, and are inconsistent with the estimation by the Lindhard's formula. In the high energy region, where the Born approximation can be used, the Bethe's formula is applied, but the experimental data are scarce. Oscillations are seen in the Z dependence graph of the experimental stopping cross sections. Experimental works on the stopping power have been done. The differential and the integral methods were carried out. (Kato, T.)

  4. Internet-based intervention for smoking cessation (StopAdvisor) in people with low and high socioeconomic status: a randomised controlled trial.

    Science.gov (United States)

    Brown, Jamie; Michie, Susan; Geraghty, Adam W A; Yardley, Lucy; Gardner, Benjamin; Shahab, Lion; Stapleton, John A; West, Robert

    2014-12-01

    groups for the primary (237 [10%] vs 220 [10%] participants; relative risk [RR] 1·06, 95% CI 0·89-1·27; p=0·49) and the secondary (358 [15%] vs 332 [15%] participants; 1·06, 0·93-1·22; p=0·37) outcomes; however, the intervention effect differed across socioeconomic status subsamples (1·44, 0·99-2·09; p=0·0562 and 1·37, 1·02-1·84; p=0·0360, respectively). StopAdvisor helped participants with low socioeconomic status stop smoking compared with the information-only website (primary outcome: 90 [8%] of 1088 vs 64 [6%] of 1054 participants; RR 1·36, 95% CI 1·00-1·86; p=0·0499; secondary outcome: 136 [13%] vs 100 [10%] participants; 1·32, 1·03-1·68, p=0·0267), but did not improve cessation rates in those with high socioeconomic status (147 [12%] of 1233 vs 156 [13%] of 1238 participants; 0·95, 0·77-1·17; p=0·61 and 222 [18%] vs 232 [19%] participants; 0·96, 0·81-1·13, p=0·64, respectively). StopAdvisor was more effective than an information-only website in smokers of low, but not high, socioeconomic status. StopAdvisor could be implemented easily and made freely available, which would probably improve the success rates of smokers with low socioeconomic status who are seeking online support. National Prevention Research Initiative. Copyright © 2014 Brown et al. Open Access article distributed under the terms of CC BY. Published by .. All rights reserved.

  5. Addition by subtraction in coupled-cluster theory: a reconsideration of the CC and CI interface and the nCC hierarchy.

    Science.gov (United States)

    Bartlett, Rodney J; Musiał, Monika

    2006-11-28

    The nCC hierarchy of coupled-cluster approximations, where n guarantees exactness for n electrons and all products of n electrons are derived and applied to several illustrative problems. The condition of exactness for n=2 defines nCCSD=2CC, with nCCSDT=3CC and nCCSDTQ=4CC being exact for three and four electrons. To achieve this, the minimum number of diagrams is evaluated, which is less than in the corresponding CC model. For all practical purposes, nCC is also the proper definition of a size-extensive CI. 2CC is also an orbitally invariant coupled electron pair approximation. The numerical results of nCC are close to those for the full CC variant, and in some cases are closer to the full CI reference result. As 2CC is exact for separated electron pairs, it is the natural zeroth-order approximation for the correlation problem in molecules with other effects introduced as these units start to interact. The nCC hierarchy of approximations has all the attractive features of CC including its size extensivity, orbital invariance, and orbital insensitivity, but in a conceptually appealing form suited to bond breaking, while being computationally less demanding. Excited states from the equation of motion (EOM-2CC) are also reported, which show results frequently approaching those of EOM-CCSDT.

  6. MRSA CC398 in the pig production chain

    NARCIS (Netherlands)

    Broens, E.M.; Graat, E.A.M.; Wolf, van der P.J.; Giessen, van de A.W.; Duijkeren, van E.; Wagenaar, J.A.; Nes, van A.; Mevius, D.J.; Jong, de M.C.M.

    2011-01-01

    In 2005, a distinct clone of methicillin resistant Staphylococcus aureus (MRSA CC398) was found in pigs and people in contact with pigs. The structure of the pig production chain in high technology pig husbandry enables pathogens to spread during animal trading, with an increasing prevalence in

  7. Get more control over your C/C++ service

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Are you looking for a way to better diagnose or monitor your C/C++ programs? Find out more about CMX - a neat, lightweight library (<32Kb) which targets this need. It allows to expose information from inside a process through a simple API, enabling pre-failure detection in combination with your favourite monitoring system.

  8. The role of CC chemokine receptor 5 in antiviral immunity

    DEFF Research Database (Denmark)

    Nansen, Anneline; Christensen, Jan Pravsgaard; Andreasen, Susanne Ørding

    2002-01-01

    The CC chemokine receptor CCR5 is an important coreceptor for human immunodeficiency virus (HIV), and there is a major thrust to develop anti-CCR5-based therapies for HIV-1. However, it is not known whether CCR5 is critical for a normal antiviral T-cell response. This study investigated the immune...

  9. Oxidative electrochemical aryl C-C coupling of spiropyrans

    NARCIS (Netherlands)

    Ivashenko, Oleksii; van Herpt, Jochem T.; Rudolf, Petra; Feringa, Ben L.; Browne, Wesley R.

    2013-01-01

    The isolation and definitive assignment of the species formed upon electrochemical oxidation of nitro-spiropyran (SP) is reported. The oxidative aryl C-C coupling at the indoline moiety of the SP radical cation to form covalent dimers of the ring-closed SP form is demonstrated. The coupling is

  10. Cell volume regulation in hemoglobin CC and AA erythrocytes

    International Nuclear Information System (INIS)

    Berkowitz, L.R.; Orringer, E.P.

    1987-01-01

    Swelling hemoglobin CC erythrocytes stimulates a ouabain-insensitive K flux that restores original cell volume. Studies were performed with the K analog, 86 Rb. This volume regulatory pathway was characterized for its anion dependence, sensitivity to loop diuretics, and requirement for Na. The swelling-induced K flux was eliminated if intracellular chloride was replaced by nitrate and both swelling-activated K influx and efflux were partially inhibited by 1 mM furosemide or bumetanide. K influx in swollen hemoglobin CC cells was not diminished when Na in the incubation medium was replaced with choline, indicating Na independence of the swelling-induced flux. Identical experiments with hemoglobin AA cells also demonstrated a swelling-induced increase in K flux, but the magnitude and duration of this increase were considerably less than that seen with hemoglobin CC cells. The increased K flux in hemoglobin AA cells was likewise sensitive to anion replacement and to loop diuretics and did not require the presence of Na. These data indicate that a volume-activated K pathway with similar transport characteristics exists in both hemoglobin CC and AA red cells

  11. Slow, stopped and stored light

    International Nuclear Information System (INIS)

    Welch, G.; Scully, M.

    2005-01-01

    Light that can been slowed to walking pace could have applications in telecommunications, optical storage and quantum computing. Whether we use it to estimate how far away a thunderstorm is, or simply take it for granted that we can have a conversation with someone on the other side of the world, we all know that light travels extremely fast. Indeed, special relativity teaches us that nothing in the universe can ever move faster than the speed of light in a vacuum: 299 792 458 ms sup - sup 1. However, there is no such limitation on how slowly light can travel. For the last few years, researchers have been routinely slowing light to just a few metres per second, and have recently even stopped it dead in its tracks so that it can be stored for future use. Slow-light has considerable popular appeal, deriving perhaps from the importance of the speed of light in relativity and cosmology. If everyday objects such as cars or people can travel faster than 'slow' light, for example, then it might appear that relativistic effects could be observed at very low speeds. Although this is not the case, slow light nonetheless promises to play an important role in optical technology because it allows light to be delayed for any period of time desired. This could lead to all-optical routers that would increase the bandwidth of the Internet, and applications in optical data storage, quantum information and even radar. (U.K.)

  12. Stopping atoms with diode lasers

    International Nuclear Information System (INIS)

    Watts, R.N.; Wieman, C.E.

    1986-01-01

    The use of light pressure to cool and stop neutral atoms has been an area of considerable interest recently. Cooled neutral atoms are needed for a variety of interesting experiments involving neutral atom traps and ultrahigh-resolution spectroscopy. Laser cooling of sodium has previously been demonstrated using elegant but quite elaborate apparatus. These techniques employed stabilized dye lasers and a variety of additional sophisticated hardware. The authors have demonstrated that a frequency chirp technique can be implemented using inexpensive diode lasers and simple electronics. In this technique the atoms in an atomic beam scatter resonant photons from a counterpropagating laser beam. The momentum transfer from the photons slows the atoms. The primary difficulty is that as the atoms slow their Doppler shift changes, and so they are no longer in resonance with the incident photons. In the frequency chirp technique this is solved by rapidly changing the laser frequency so that the atoms remain in resonance. To achieve the necessary frequency sweep with a dye laser one must use an extremely sophisticated high-speed electrooptic modulator. With a diode laser, however, the frequency can be smoothly and rapidly varied over many gigahertz simply by changing the injection current

  13. The Clinical Study on Acupuncture Sensation in CC, CF and BV Herbal Acupuncture -The Basic Study on Placebo Herbal Acupuncture-

    Directory of Open Access Journals (Sweden)

    Seo Jung-Chul

    2004-02-01

    Full Text Available Objective : This study was designed to find out whether NS(normal saline is able to be constituted as an appropriate control group for CC(Cervi Cornu Parvum herbal acupuncture, CF(Carthami-Flos herbal acupuncture and BV(bee venom herbal acupuncture. Methods : NS and three herbal acupuncture were inserted into Quchi(LI 11 of the subjects. After 5 minutes the subjects completed a questionnaire rating the intensity of 21 kinds of acupuncture sensation; hurting, penetrating, sharp, aching, intense, spreading, radiating, tingling, pricking, stinging, pulling, heavy, dull, numb, electric, shocking, hot, burning, cool, pulsing, and throbbing. We compared subjective evaluations of acupuncture sensation between or among the groups. Results : As for CC half items of the acupuncture sensation were significantly different from NS. As for CF all items were not significantly different from NS. As for CC all items were significantly different from NS except one item. In general the score of CF acupuncture sensation was lower than the others and the score of BV acupuncture sensation was higher than the others from comparison of sensation among herbal acupunctures(CC, CF, BV. Conclusion : We found that NS is able to be an appropriate placebo herbal acupuncture for CF. Further study is needed for new placebo herbal acupuncture for CC and BV.

  14. Electron and Positron Stopping Powers of Materials

    Science.gov (United States)

    SRD 7 NIST Electron and Positron Stopping Powers of Materials (PC database for purchase)   The EPSTAR database provides rapid calculations of stopping powers (collisional, radiative, and total), CSDA ranges, radiation yields and density effect corrections for incident electrons or positrons with kinetic energies from 1 keV to 10 GeV, and for any chemically defined target material.

  15. Addressing production stops in the food industry

    DEFF Research Database (Denmark)

    Hansen, Zaza Nadja Lee; Herbert, Luke Thomas; Jacobsen, Peter

    2014-01-01

    This paper investigates the challenges in the food industry which causes the production lines to stop, illustrated by a case study of an SME size company in the baked goods sector in Denmark. The paper proposes key elements this sector needs to be aware of to effectively address production stops......, and gives examples of the unique challenges faced by the SME food industry....

  16. Perceptual assessment of fricative--stop coarticulation.

    Science.gov (United States)

    Repp, B H; Mann, V A

    1981-04-01

    The perceptual dependence of stop consonants on preceding fricatives [Mann and Repp, J. Acoust. Soc. Am. 69, 548--558 (1981)] was further investigated in two experiments employing both natural and synthetic speech. These experiments consistently replicated our original finding that listeners, report velar stops following [s]. In addition, our data confirmed earlier reports that natural fricative noises (excerpted from utterances of [st alpha], [sk alpha], [(formula: see text)k alpha]) contain cues to the following stop consonants; this was revealed in subjects' identifications of stops from isolated fricative noises and from stimuli consisting of these noises followed by synthetic CV portions drawn from a [t alpha]--[k alpha] continuum. However, these cues in the noise portion could not account for the contextual effect of fricative identity ([formula: see text] versus [sp) on stop perception (more "k" responses following [s]). Rather, this effect seems to be related to a coarticulatory influence of a preceding fricative on stop production; Subjects' responses to excised natural CV portions (with bursts and aspiration removed) were biased towards a relatively more forward place of stop articulation when the CVs had originally been preceded by [s]; and the identification of a preceding ambiguous fricative was biased in the direction of the original fricative context in which a given CV portion had been produced. These findings support an articulatory explanation for the effect of preceding fricatives on stop consonant perception.

  17. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... of hangnails, or other triggers, such as boredom, stress, or anxiety. By figuring out what causes you to bite your nails, you can figure out how to avoid these situations and develop a plan to stop. Just knowing when you’re inclined to bite may help solve the problem. Try to gradually stop biting ...

  18. All in One Stop? The Accessibility of Work Support Programs at One-Stop Centers.

    Science.gov (United States)

    Richer, Elise; Kubo, Hitomi; Frank, Abbey

    The accessibility of work support programs at one-stop centers was examined in a study during which 33 telephone directors or managers of one-stop centers in 22 states were interviewed by telephone. The interviews established the existence of extensive differences between one-stop centers from the standpoint of all aspects of their operation,…

  19. Stopping of hypervelocity clusters in solids

    International Nuclear Information System (INIS)

    Anders, Christian; Ziegenhain, Gerolf; Urbassek, Herbert M; Bringa, Eduardo M

    2011-01-01

    Using molecular-dynamics simulations, we study the processes underlying the stopping of energetic clusters upon impact in matter. We investigate self-bombardment of both a metallic (Cu) and a van-der-Waals bonded (frozen Ar) target. Clusters with sizes up to N = 10 4 atoms and with energies per atom of E/N = 0.1-1600 eV atom -1 were studied. We find that the stopping force exerted on a cluster follows an N 2/3 -dependence with cluster size N; thus large clusters experience less stopping than equi-velocity atoms. In the course of being stopped, the cluster is strongly deformed and attains a roughly pancake shape. Due to the cluster inertia, maximum deformation occurs later than the maximum stopping force. The time scale of projectile stopping is set by t 0 , the time the cluster needs to cover its own diameter before impacting the target; it thus depends on both cluster size and velocity. The time when the cluster experiences its maximum stopping force is around (0.7-0.8)t 0 . We find that the cluster is deformed with huge strain rates of around 1/2t 0 ; this amounts to 10 11 -10 13 s -1 for the cases studied here. (paper)

  20. A light sneutrino rescues the light stop

    Energy Technology Data Exchange (ETDEWEB)

    Chala, M. [Departament de Física Tèorica, Universitat de València and IFIC, Universitat de València-CSIC,Dr. Moliner 50, E-46100 Burjassot (València) (Spain); Delgado, A. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Nardini, G. [Albert Einstein Center (AEC), Institute for Theoretical Physics (ITP), University of Bern,Sidlerstrasse 5, CH-3012 Bern (Switzerland); Quirós, M. [Institut de Física d’Altes Energies (IFAE), The Barcelona Institute of Science and Technology (BIST),Institució Catalana de Recerca i Estudis Avançats - ICREA, Campus UAB, 08193 Bellaterra, Barcelona (Spain)

    2017-04-18

    Stop searches in supersymmetric frameworks with R-parity conservation usually assume the lightest neutralino to be the lightest supersymmetric particle. In this paper we consider an alternative scenario in which the left-handed tau sneutrino is lighter than neutralinos and stable at collider scales, but possibly unstable at cosmological scales. Moreover the (mostly right-handed) stop t̃ is lighter than all electroweakinos, and heavier than the scalars of the third generation lepton doublet, whose charged component, τ̃, is heavier than the neutral one, ν̃. The remaining supersymmetric particles are decoupled from the stop phenomenology. In most of the parameter space, the relevant stop decays are only into tτ̃τ, tν̃ν and bν̃τ via off-shell electroweakinos. We constrain the branching ratios of these decays by recasting the most sensitive stop searches. Due to the “double invisible” kinematics of the t̃→tν̃ν process, and the low efficiency in tagging the tτ̃τ decay products, light stops are generically allowed. In the minimal supersymmetric standard model with ∼ 100 GeV sneutrinos, stops with masses as small as ∼ 350 GeV turn out to be allowed at 95% CL.

  1. Energy Materials Coordinating Committee (EMaCC) annual technical report, fiscal year 1984 with fiscal year 1985 data

    Energy Technology Data Exchange (ETDEWEB)

    None

    1985-07-01

    The Department of Energy funded about 374 million dollars of materials science and technology activities in both fiscal years 1984 and 1985. These funds and the commensurate program management responsibilities resided in 21 DOE program offices, each of which has its own mission and responsibilities. The Energy Materials Coordinating Committee (EMaCC) provides a formal mechanism to insure coordinated planning and maximum programmatic effectiveness for the Department's 374 million dollar per year materials effort. The EMaCC reports to the Director of the Office of Energy Research who in turn has oversight responsibilities for proper coordination of the technical programs of the Department. In carrying out this responsibility, EMaCC hosts meetings, organizes working groups, and publishes an annual technical report. This report is mandated by the EMaCC Terms of Reference. Its purpose is to disseminate information on the DOE materials programs for more effective coordination. It describes the materials research programs of various offices and divisions within the Department for FY 1984, contains funding information for FYs 1984 and 1985, and summarizes EMaCC activities for FY 1985.

  2. Commercial Biocides Induce Transfer of Prophage Φ13 from Human Strains of Staphylococcus aureus to Livestock CC398

    Directory of Open Access Journals (Sweden)

    Yuanyue Tang

    2017-12-01

    Full Text Available Human strains of Staphylococcus aureus commonly carry the bacteriophage ΦSa3 that encodes immune evasion factors. Recently, this prophage has been found in livestock-associated, methicillin resistant S. aureus (MRSA CC398 strains where it may promote human colonization. Here, we have addressed if exposure to biocidal products induces phage transfer, and find that during co-culture, Φ13 from strain 8325, belonging to ΦSa3 group, is induced and transferred from a human strain to LA-MRSA CC398 when exposed to sub-lethal concentrations of commercial biocides containing hydrogen peroxide. Integration of ΦSa3 in LA-MRSA CC398 occurs at multiple positions and the integration site influences the stability of the prophage. We did not observe integration in hlb encoding β-hemolysin that contains the preferred ΦSa3 attachment site in human strains, and we demonstrate that this is due to allelic variation in CC398 strains that disrupts the phage attachment site, but not the expression of β-hemolysin. Our results show that hydrogen peroxide present in biocidal products stimulate transfer of ΦSa3 from human to LA-MRSA CC398 strains and that in these strains prophage stability depends on the integration site. Knowledge of ΦSa3 transfer and stability between human and livestock strains may lead to new intervention measures directed at reducing human infection by LA-MRSA strains.

  3. Commercial Biocides Induce Transfer of Prophage Φ13 from Human Strains of Staphylococcus aureus to Livestock CC398.

    Science.gov (United States)

    Tang, Yuanyue; Nielsen, Lene N; Hvitved, Annemette; Haaber, Jakob K; Wirtz, Christiane; Andersen, Paal S; Larsen, Jesper; Wolz, Christiane; Ingmer, Hanne

    2017-01-01

    Human strains of Staphylococcus aureus commonly carry the bacteriophage ΦSa3 that encodes immune evasion factors. Recently, this prophage has been found in livestock-associated, methicillin resistant S. aureus (MRSA) CC398 strains where it may promote human colonization. Here, we have addressed if exposure to biocidal products induces phage transfer, and find that during co-culture, Φ13 from strain 8325, belonging to ΦSa3 group, is induced and transferred from a human strain to LA-MRSA CC398 when exposed to sub-lethal concentrations of commercial biocides containing hydrogen peroxide. Integration of ΦSa3 in LA-MRSA CC398 occurs at multiple positions and the integration site influences the stability of the prophage. We did not observe integration in hlb encoding β-hemolysin that contains the preferred ΦSa3 attachment site in human strains, and we demonstrate that this is due to allelic variation in CC398 strains that disrupts the phage attachment site, but not the expression of β-hemolysin. Our results show that hydrogen peroxide present in biocidal products stimulate transfer of ΦSa3 from human to LA-MRSA CC398 strains and that in these strains prophage stability depends on the integration site. Knowledge of ΦSa3 transfer and stability between human and livestock strains may lead to new intervention measures directed at reducing human infection by LA-MRSA strains.

  4. Energy Materials Coordinating Committee (EMaCC) annual technical report, fiscal year 1984 with fiscal year 1985 data

    International Nuclear Information System (INIS)

    1985-07-01

    The Department of Energy funded about 374 million dollars of materials science and technology activities in both fiscal years 1984 and 1985. These funds and the commensurate program management responsibilities resided in 21 DOE program offices, each of which has its own mission and responsibilities. The Energy Materials Coordinating Committee (EMaCC) provides a formal mechanism to insure coordinated planning and maximum programmatic effectiveness for the Department's 374 million dollar per year materials effort. The EMaCC reports to the Director of the Office of Energy Research who in turn has oversight responsibilities for proper coordination of the technical programs of the Department. In carrying out this responsibility, EMaCC hosts meetings, organizes working groups, and publishes an annual technical report. This report is mandated by the EMaCC Terms of Reference. Its purpose is to disseminate information on the DOE materials programs for more effective coordination. It describes the materials research programs of various offices and divisions within the Department for FY 1984, contains funding information for FYs 1984 and 1985, and summarizes EMaCC activities for FY 1985

  5. Recent Advances in Ring-Opening Functionalization of Cycloalkanols by C-C σ-Bond Cleavage.

    Science.gov (United States)

    Wu, Xinxin; Zhu, Chen

    2018-06-01

    Cycloalkanols prove to be privileged precursors for the synthesis of distally substituted alkyl ketones and polycyclic aromatic hydrocarbons (PAHs) by virtue of cleavage of their cyclic C-C bonds. Direct functionalization of cyclobutanols to build up other chemical bonds (e. g., C-F, C-Cl, C-Br, C-N, C-S, C-Se, C-C, etc.) has been achieved by using the ring-opening strategy. Mechanistically, the C-C cleavage of cyclobutanols can be involved in two pathways: (a) transition-metal catalyzed β-carbon elimination; (b) radical-mediated 'radical clock'-type ring opening. The recent advances of our group for the ring-opening functionalization of tertiary cycloalkanols are described in this account. © 2018 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Forging C-C Bonds Through Decarbonylation of Aryl Ketones.

    Science.gov (United States)

    Somerville, Rosie J; Martin, Ruben

    2017-06-06

    The ability of nickel to cleave strong σ-bonds is again in the spotlight after a recent report that demonstrates the feasibility of using nickel complexes to promote decarbonylation of diaryl ketones. This transformation involves the cleavage of two strong C-C(O) bonds and avoids the use of noble metals, hence reinforcing the potential of decarbonylation as a technique for forging C-C bonds. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. CC1, a novel crenarchaeal DNA binding protein.

    Science.gov (United States)

    Luo, Xiao; Schwarz-Linek, Uli; Botting, Catherine H; Hensel, Reinhard; Siebers, Bettina; White, Malcolm F

    2007-01-01

    The genomes of the related crenarchaea Pyrobaculum aerophilum and Thermoproteus tenax lack any obvious gene encoding a single-stranded DNA binding protein (SSB). SSBs are essential for DNA replication, recombination, and repair and are found in all other genomes across the three domains of life. These two archaeal genomes also have only one identifiable gene encoding a chromatin protein (the Alba protein), while most other archaea have at least two different abundant chromatin proteins. We performed a biochemical screen for novel nucleic acid binding proteins present in cell extracts of T. tenax. An assay for proteins capable of binding to a single-stranded DNA oligonucleotide resulted in identification of three proteins. The first protein, Alba, has been shown previously to bind single-stranded DNA as well as duplex DNA. The two other proteins, which we designated CC1 (for crenarchaeal chromatin protein 1), are very closely related to one another, and homologs are restricted to the P. aerophilum and Aeropyrum pernix genomes. CC1 is a 6-kDa, monomeric, basic protein that is expressed at a high level in T. tenax. This protein binds single- and double-stranded DNAs with similar affinities. These properties are consistent with a role for CC1 as a crenarchaeal chromatin protein.

  8. Observation of the Doubly Charmed Baryon Ξ_{cc}^{++}.

    Science.gov (United States)

    Aaij, R; Adeva, B; Adinolfi, M; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Alfonso Albero, A; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Archilli, F; d'Argent, P; Arnau Romeu, J; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Babuschkin, I; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baker, S; Balagura, V; Baldini, W; Baranov, A; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Baryshnikov, F; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Beiter, A; Bel, L J; Beliy, N; Bellee, V; Belloli, N; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Beranek, S; Berezhnoy, A; Bernet, R; Berninghoff, D; Bertholet, E; Bertolin, A; Betancourt, C; Betti, F; Bettler, M-O; van Beuzekom, M; Bezshyiko, Ia; Bifani, S; Billoir, P; Birnkraut, A; Bitadze, A; Bizzeti, A; Bjoern, M B; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Boettcher, T; Bondar, A; Bondar, N; Bonivento, W; Bordyuzhin, I; Borgheresi, A; Borghi, S; Borisyak, M; Borsato, M; Borysova, M; Bossu, F; Boubdir, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britton, T; Brodzicka, J; Brundu, D; Buchanan, E; Burr, C; Bursche, A; Buytaert, J; Byczynski, W; Cadeddu, S; Cai, H; Calabrese, R; Calladine, R; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D H; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cavallero, G; Cenci, R; Chamont, D; Charles, M; Charpentier, Ph; Chatzikonstantinidis, G; Chefdeville, M; Chen, S; Cheung, S F; Chitic, S-G; Chobanova, V; Chrzaszcz, M; Chubykin, A; Ciambrone, P; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collins, P; Colombo, T; Comerma-Montells, A; Contu, A; Cook, A; Coombs, G; Coquereau, S; Corti, G; Corvo, M; Costa Sobral, C M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Currie, R; D'Ambrosio, C; Da Cunha Marinho, F; Dall'Occo, E; Dalseno, J; Davis, A; De Aguiar Francisco, O; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Serio, M; De Simone, P; Dean, C T; Decamp, D; Del Buono, L; Dembinski, H-P; Demmer, M; Dendek, A; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Di Nezza, P; Dijkstra, H; Dordei, F; Dorigo, M; Dosil Suárez, A; Douglas, L; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Durante, P; Dzhelyadin, R; Dziewiecki, M; Dziurda, A; Dzyuba, A; Easo, S; Ebert, M; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Farley, N; Farry, S; Fay, R; Fazzini, D; Federici, L; Ferguson, D; Fernandez, G; Fernandez Declara, P; Fernandez Prieto, A; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fini, R A; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fleuret, F; Fohl, K; Fontana, M; Fontanelli, F; Forshaw, D C; Forty, R; Franco Lima, V; Frank, M; Frei, C; Fu, J; Funk, W; Furfaro, E; Färber, C; Gabriel, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; Garcia Martin, L M; García Pardiñas, J; Garra Tico, J; Garrido, L; Garsed, P J; Gascon, D; Gaspar, C; Gavardi, L; Gazzoni, G; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gizdov, K; Gligorov, V V; Golubkov, D; Golutvin, A; Gomes, A; Gorelov, I V; Gotti, C; Govorkova, E; Grabowski, J P; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Greim, R; Griffith, P; Grillo, L; Gruber, L; Gruberg Cazon, B R; Grünberg, O; Gushchin, E; Guz, Yu; Gys, T; Göbel, C; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hamilton, B; Han, X; Hancock, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hasse, C; Hatch, M; He, J; Hecker, M; Heinicke, K; Heister, A; Hennessy, K; Henrard, P; Henry, L; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hombach, C; Hopchev, P H; Huard, Z-C; Hulsbergen, W; Humair, T; Hushchyn, M; Hutchcroft, D; Ibis, P; Idzik, M; Ilten, P; Jacobsson, R; Jalocha, J; Jans, E; Jawahery, A; Jiang, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Karacson, M; Kariuki, J M; Karodia, S; Kazeev, N; Kecke, M; Kelsey, M; Kenzie, M; Ketel, T; Khairullin, E; Khanji, B; Khurewathanakul, C; Kirn, T; Klaver, S; Klimaszewski, K; Klimkovich, T; Koliiev, S; Kolpin, M; Komarov, I; Kopecna, R; Koppenburg, P; Kosmyntseva, A; Kotriakhova, S; Kozeiha, M; Kreps, M; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kurek, K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Leflat, A; Lefrançois, J; Lefèvre, R; Lemaitre, F; Lemos Cid, E; Leroy, O; Lesiak, T; Leverington, B; Li, P-R; Li, T; Li, Y; Li, Z; Likhomanenko, T; Lindner, R; Lionetto, F; Lisovskyi, V; Liu, X; Loh, D; Loi, A; Longstaff, I; Lopes, J H; Lucchesi, D; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusiani, A; Lyu, X; Machefert, F; Maciuc, F; Macko, V; Mackowiak, P; Maddock, B; Maddrell-Mander, S; Maev, O; Maguire, K; Maisuzenko, D; Majewski, M W; Malde, S; Malinin, A; Maltsev, T; Manca, G; Mancinelli, G; Manning, P; Marangotto, D; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marinangeli, M; Marino, P; Marks, J; Martellotti, G; Martin, M; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massacrier, L M; Massafferri, A; Matev, R; Mathad, A; Mathe, Z; Matteuzzi, C; Mauri, A; Maurice, E; Maurin, B; Mazurov, A; McCann, M; McNab, A; McNulty, R; Mead, J V; Meadows, B; Meaux, C; Meier, F; Meinert, N; Melnychuk, D; Merk, M; Merli, A; Michielin, E; Milanes, D A; Millard, E; Minard, M-N; Minzoni, L; Mitzel, D S; Mogini, A; Molina Rodriguez, J; Mombacher, T; Monroy, I A; Monteil, S; Morandin, M; Morello, M J; Morgunova, O; Moron, J; Morris, A B; Mountain, R; Muheim, F; Mulder, M; Müller, D; Müller, J; Müller, K; Müller, V; Naik, P; Nakada, T; Nandakumar, R; Nandi, A; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, T D; Nguyen-Mau, C; Nieswand, S; Niet, R; Nikitin, N; Nikodem, T; Nogay, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Ogilvy, S; Oldeman, R; Onderwater, C J G; Ossowska, A; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pais, P R; Palano, A; Palutan, M; Papanestis, A; Pappagallo, M; Pappalardo, L L; Pappenheimer, C; Parker, W; Parkes, C; Passaleva, G; Pastore, A; Patel, M; Patrignani, C; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perret, P; Pescatore, L; Petridis, K; Petrolini, A; Petrov, A; Petruzzo, M; Picatoste Olloqui, E; Pietrzyk, B; Pikies, M; Pinci, D; Pistone, A; Piucci, A; Placinta, V; Playfer, S; Plo Casasus, M; Polci, F; Poli Lener, M; Poluektov, A; Polyakov, I; Polycarpo, E; Pomery, G J; Ponce, S; Popov, A; Popov, D; Poslavskii, S; Potterat, C; Price, E; Prisciandaro, J; Prouve, C; Pugatch, V; Puig Navarro, A; Pullen, H; Punzi, G; Qian, W; Quagliani, R; Quintana, B; Rachwal, B; Rademacker, J H; Rama, M; Ramos Pernas, M; Rangel, M S; Raniuk, I; Ratnikov, F; Raven, G; Ravonel Salzgeber, M; Reboud, M; Redi, F; Reichert, S; Dos Reis, A C; Remon Alepuz, C; Renaudin, V; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Robbe, P; Robert, A; Rodrigues, A B; Rodrigues, E; Rodriguez Lopez, J A; Rodriguez Perez, P; Rogozhnikov, A; Roiser, S; Rollings, A; Romanovskiy, V; Romero Vidal, A; Ronayne, J W; Rotondo, M; Rudolph, M S; Ruf, T; Ruiz Valls, P; Ruiz Vidal, J; Saborido Silva, J J; Sadykhov, E; Sagidova, N; Saitta, B; Salustino Guimaraes, V; Sanchez Gonzalo, D; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santimaria, M; Santovetti, E; Sarpis, G; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrina, D; Schael, S; Schellenberg, M; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmelzer, T; Schmidt, B; Schneider, O; Schopper, A; Schreiner, H F; Schubert, K; Schubiger, M; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Semennikov, A; Sergi, A; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Siddi, B G; Silva Coutinho, R; Silva de Oliveira, L; Simi, G; Simone, S; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, E; Smith, I T; Smith, J; Smith, M; Soares Lavra, L; Sokoloff, M D; Soler, F J P; Souza De Paula, B; Spaan, B; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Stefko, P; Stefkova, S; Steinkamp, O; Stemmle, S; Stenyakin, O; Stepanova, M; Stevens, H; Stone, S; Storaci, B; Stracka, S; Stramaglia, M E; Straticiuc, M; Straumann, U; Sun, L; Sutcliffe, W; Swientek, K; Syropoulos, V; Szczekowski, M; Szumlak, T; Szymanski, M; T'Jampens, S; Tayduganov, A; Tekampe, T; Tellarini, G; Teubert, F; Thomas, E; van Tilburg, J; Tilley, M J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Toriello, F; Tourinho Jadallah Aoude, R; Tournefier, E; Traill, M; Tran, M T; Tresch, M; Trisovic, A; Tsaregorodtsev, A; Tsopelas, P; Tully, A; Tuning, N; Ukleja, A; Usachov, A; Ustyuzhanin, A; Uwer, U; Vacca, C; Vagner, A; Vagnoni, V; Valassi, A; Valat, S; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; van Veghel, M; Velthuis, J J; Veltri, M; Veneziano, G; Venkateswaran, A; Verlage, T A; Vernet, M; Vesterinen, M; Viana Barbosa, J V; Viaud, B; Vieira, D; Vieites Diaz, M; Viemann, H; Vilasis-Cardona, X; Vitti, M; Volkov, V; Vollhardt, A; Voneki, B; Vorobyev, A; Vorobyev, V; Voß, C; de Vries, J A; Vázquez Sierra, C; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wang, J; Ward, D R; Wark, H M; Watson, N K; Websdale, D; Weiden, A; Whitehead, M; Wicht, J; Wilkinson, G; Wilkinson, M; Williams, M; Williams, M P; Williams, M; Williams, T; Wilson, F F; Wimberley, J; Winn, M A; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wraight, K; Wyllie, K; Xie, Y; Xu, Z; Yang, Z; Yang, Z; Yao, Y; Yin, H; Yu, J; Yuan, X; Yushchenko, O; Zarebski, K A; Zavertyaev, M; Zhang, L; Zhang, Y; Zhelezov, A; Zheng, Y; Zhu, X; Zhukov, V; Zonneveld, J B; Zucchelli, S

    2017-09-15

    A highly significant structure is observed in the Λ_{c}^{+}K^{-}π^{+}π^{+} mass spectrum, where the Λ_{c}^{+} baryon is reconstructed in the decay mode pK^{-}π^{+}. The structure is consistent with originating from a weakly decaying particle, identified as the doubly charmed baryon Ξ_{cc}^{++}. The difference between the masses of the Ξ_{cc}^{++} and Λ_{c}^{+} states is measured to be 1334.94±0.72(stat.)±0.27(syst.)  MeV/c^{2}, and the Ξ_{cc}^{++} mass is then determined to be 3621.40±0.72(stat.)±0.27(syst.)±0.14(Λ_{c}^{+})  MeV/c^{2}, where the last uncertainty is due to the limited knowledge of the Λ_{c}^{+} mass. The state is observed in a sample of proton-proton collision data collected by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.7  fb^{-1}, and confirmed in an additional sample of data collected at 8 TeV.

  9. Global Analysis of Solar Neutrino Oscillations Including SNO CC Measurement

    CERN Document Server

    Bahcall, J N; Peña-Garay, C; Bahcall, John N; Peña-Garay, Carlos

    2001-01-01

    For active and sterile neutrinos, we present the globally allowed solutions for two neutrino oscillations. We include the SNO CC measurement and all other relevant solar neutrino and reactor data. Five active neutrino oscillation solutions (LMA, LOW, SMA, VAC, and Just So2) are currently allowed at 3 sigma; three sterile neutrino solutions (Just So2, SMA, and VAC) are allowed at 3 sigma. The goodness of fit is satisfactory for all eight solutions. We also investigate the robustness of the allowed solutions by carrying out global analyses with and without: 1) imposing solar model constraints on the 8B neutrino flux, 2) including the Super-Kamiokande spectral energy distribution and day-night data, 3) using an enhanced CC cross section for deuterium (due to radiative corrections), and 4) a optimistic, hypothetical reduction by a factor of three of the error of the SNO CC rate. For every analysis strategy used in this paper, the most favored solutions all involve large mixing angles: LMA, LOW, or VAC. The favore...

  10. Using the Stop Transmission of Polio (STOP) Program to Develop a South Sudan Expanded Program on Immunization Workforce.

    Science.gov (United States)

    Tchoualeu, Dieula D; Hercules, Margaret A; Mbabazi, William B; Kirbak, Anthony L; Usman, Abdulmumini; Bizuneh, Ketema; Sandhu, Hardeep S

    2017-07-01

    In 2009, the international Stop Transmission of Polio (STOP) program began supporting the Global Polio Eradication Initiative in the Republic of South Sudan to address shortages of human resources and strengthen acute flaccid paralysis surveillance. Workforce capacity support is provided to the South Sudan Expanded Program on Immunization by STOP volunteers, implementing partners, and non-governmental organizations. In 2013, the Polio Technical Advisory Group recommended that South Sudan transition key technical support from external partners to national staff as part of the Polio Eradication and Endgame Strategic Plan, 2013-2018. To assist in this transition, the South Sudan Expanded Program on Immunization human resources development project was launched in 2015. This 3-year project aims to build national workforce capacity as a legacy of the STOP program by training 56 South Sudanese at national and state levels with the intent that participants would become Ministry of Health staff on their successful completion of the project. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

  11. The effect of starting or stopping skin cooling on the thermoregulatory responses during leg exercise in humans.

    Science.gov (United States)

    Demachi, K; Yoshida, T; Kume, M; Tsuneoka, H

    2012-07-01

    To assess the effects of starting or stopping leg cooling on the thermoregulatory responses during exercise, 60 min of cycling exercise at 30% of maximal oxygen uptake was performed under 4 conditions using tube trouser perfused with water at 10 °C; no leg cooling (NC), starting of leg cooling after 30 min of exercise (delayed cooling, DC), continuous leg cooling (CC), and stopping of continuous leg cooling after 30 min of exercise (SC) at an environmental temperature of 28.5 °C. During exercise under the DC conditions, an instantaneous increase in the esophageal temperature (Tes), a suppression of the cutaneous vascular conductance at the forearm (%CVC), and a decrease in the mean skin temperature (Tsk) were observed after leg cooling. The total sweat loss (Δm sw,tot) was lower under the DC than the NC condition. In the SC study, however, the Tes remained constant, while the %CVC increased gradually after leg cooling was stopped, and the Δm sw,tot was greater than that under the CC condition. These results suggest that during exercise, rapid skin cooling of the leg may cause an increase in core temperature, while also enhancing thermal stress. However, stopping skin cooling did not significantly affect the core temperature long-term, because the skin blood flow and sweat rate subsequently increased. © Georg Thieme Verlag KG Stuttgart · New York.

  12. Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies

    International Nuclear Information System (INIS)

    Eder, Matthias; Waengler, Bjoern; Eisenhut, Michael; Knackmuss, Stefan; LeGall, Fabrice; Little, Melvyn; Haberkorn, Uwe; Mier, Walter

    2008-01-01

    The success of 68 Ga-labeled peptides for positron emission tomography of neuroendocrine tumors is mainly depending on the complex chemistry of this radioisotope. 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the chelator of choice has however limitations if its application is expanded to heat-sensitive proteins. Recombinant antibodies like single chain Fv or diabodies belong to this class of proteins. They are suited to provide imaging contrast despite the short-lived 68 Ga because of their rapid blood clearances and nanomolar affinities. The heterobifunctional agent N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid (HBED-CC) was chosen as an alternative ligand because this agent is complexing [ 68 Ga]Ga 3+ much faster than DOTA at ambient temperatures. A versatile technology for HBED-CC conjugation of proteins and 68 Ga-labeling has been developed. This included HBED-CC-tetrafluorophenol (TFP) ester synthesis, coupling to the antibody at various pH and complexation reactions performed in 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer under different conditions. The synthesis of the monoreactive 2,3,5,6-tetrafluorophenolate of HBED-CC at a carboxyl group not participating in complex formation used [Fe(HBED-CC)] - for ester formation. The removal of Fe 3+ from purified (HBED-CC)TFP ester was achieved with RP 18 cartridge technology. The conjugation chemistry was performed with mAb425 which binds to the epidermal growth factor receptor (EGFR). This protein was used for optimizing purposes only. The influence of complexation parameters like temperature, pH, reaction time, and HBED-CC/antibody ratio on the biological activity of this model antibody was investigated. Furthermore, the outcome of this labeling procedure on the biological activity of a recombinant diabody (50 kDa) was studied. It is known that small HBED-CC/antibody ratios are prerequisites for minimal interference of labels with antigen

  13. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... figure out how to avoid these situations and develop a plan to stop. Just knowing when you’ ... a doctor. If you bite your nails and develop a skin or nail infection, consult a board- ...

  14. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... your nails to your face and mouth. To help you stop biting your nails, dermatologists recommend the ... stress ball or silly putty instead. This will help keep your hands busy and away from your ...

  15. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... and away from your mouth. Identify your triggers: These could be physical triggers, such as the presence ... nails, you can figure out how to avoid these situations and develop a plan to stop. Just ...

  16. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... Skin dictionary Camp Discovery Good Skin Knowledge lesson plans and activities Video library Find a dermatologist Why ... how to avoid these situations and develop a plan to stop. Just knowing when you’re inclined ...

  17. Port Authority of Allegheny County Transit Stops

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — All transit stops within the Port Authority of Allegheny County's service area for the November 20, 2016 - March (TBD) 2017 schedule period.

  18. Imagine stopping the progression of Alzheimer's

    Science.gov (United States)

    ... Issue Past Issues Imagine stopping the progression of Alzheimer's Past Issues / Fall 2006 Table of Contents For ... I have friends and loved ones suffering from Alzheimer's. But I can imagine… and hope for… a ...

  19. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... Part 2: Origin Part 3: Function Textbook Study notes Image library 3-D animated image library Board ... gradually stop biting your nails: Some doctors recommend taking a gradual approach to break the habit. Try ...

  20. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... Mohs AUC MyDermPath+ Psoriasis Patient education resources Practice Management Center Coding and reimbursement Coding MACRA Fee schedule ... your nails: Some doctors recommend taking a gradual approach to break the habit. Try to stop biting ...

  1. Implementation of Integrated Management of Childhood Illness Community Component (IMCI-CC in Oman: A Situation Analysis

    Directory of Open Access Journals (Sweden)

    Fannah Abdullah Alfannah

    2017-12-01

    Full Text Available Objective: To identify the baseline data for selected key family practices for implementing the Community Component of IMCI in the Muscat Governorate, Sultanate of Oman. For this purpose, we conducted a situation analysis to assess the adherence to the key family practices. Methods: A pre-tested structured qualitative questionnaire was developed. Data were collected from the participants (mothers with an Anti Natal Card Number (ANC living in the Muscat Governorate. The data collection started from January 2014 and concluded in December 2014. The 12 key family practices were adopted from World Health Organization (WHO and modified according to the Omani context. Capacity building to perform the field survey followed this. The capacity building was based on identifying the regional focal points along with the task force that consisted of head of Health Education in each district (Wilayat and identifying the Community Support Groups (CSGs. The task force was trained to reach out to the participants and get the responses on a voluntary basis. Results: Only 9% of the participants were exclusively breast-feeding their infants, 26% reduced feeding when their children had diarrhea while 6% stopped feeding their child completely, 19.1% did not know how to prepare Oral Rehydration Solution (ORS, 61% took their child to a medical facility immediately when there was cough or cold, 22% started complimentary feeding before the age of 6 months, 12.7% did not know about the WHO recommended total calorie intake for their child, 15.5% did not have any idea about the dietary requirements for their children, 39% stated that if their child had diarrhea, they would not change the diet, 12% stated that they had no idea about the general danger signs, 55.8% stated that cough and cold was a direct consequence of exposing the child to cold weather, 23% stated that in a situation where their child was not improving, they would immediately change the doctor. Conclusion

  2. Empirical stopping powers for ions in solids

    International Nuclear Information System (INIS)

    Ziegler, J.F.; Biersack, J.P.; Littmark, U.

    1983-01-01

    The work of Brandt and collaborators on low energy ion stopping powers has been extended to create an empirical formulation for the stopping of ions in solids. The result is a simple computer program (about 60 lines of code) which calculates stopping powers from zero to 100 MeV/amu for all ions in all elemental solids. This code has been compared to the data in about 2000 papers, and has a standard error of 9% for energies above keV/amu. This approach includes high energy relativistic effects and shell-corrections. In the medium energy range it uses stopping theory based on the local-density approximation and Lindhard stopping in a free electron gas. This is applied to realistic Hartree-Fock charge distributions for crystalline solids. In the low energy range it uses the Brandt concepts of ion stripping relative to the Fermi velocity of solids, and also his formalism for the relation of projectile ionization to its effective charge. The details of the calculation are presented, and a broad comparison is shown with experiment. Special comparative examples are shown of both the low energy stopping power oscillations which depend on the atomic number of the ion, and also of the target

  3. Transcriptomes of Frankia sp. strain CcI3 in growth transitions

    Directory of Open Access Journals (Sweden)

    Bickhart Derek M

    2011-08-01

    Full Text Available Abstract Background Frankia sp. strains are actinobacteria that form N2-fixing root nodules on angiosperms. Several reference genome sequences are available enabling transcriptome studies in Frankia sp. Genomes from Frankia sp. strains differ markedly in size, a consequence proposed to be associated with a high number of indigenous transposases, more than 200 of which are found in Frankia sp. strain CcI3 used in this study. Because Frankia exhibits a high degree of cell heterogeneity as a consequence of its mycelial growth pattern, its transcriptome is likely to be quite sensitive to culture age. This study focuses on the behavior of the Frankia sp. strain CcI3 transcriptome as a function of nitrogen source and culture age. Results To study global transcription in Frankia sp. CcI3 grown under different conditions, complete transcriptomes were determined using high throughput RNA deep sequencing. Samples varied by time (five days vs. three days and by culture conditions (NH4+ added vs. N2 fixing. Assembly of millions of reads revealed more diversity of gene expression between five-day and three-day old cultures than between three day old cultures differing in nitrogen sources. Heat map analysis organized genes into groups that were expressed or repressed under the various conditions compared to median expression values. Twenty-one SNPs common to all three transcriptome samples were detected indicating culture heterogeneity in this slow-growing organism. Significantly higher expression of transposase ORFs was found in the five-day and N2-fixing cultures, suggesting that N starvation and culture aging provide conditions for on-going genome modification. Transposases have previously been proposed to participate in the creating the large number of gene duplication or deletion in host strains. Subsequent RT-qPCR experiments confirmed predicted elevated transposase expression levels indicated by the mRNA-seq data. Conclusions The overall pattern of

  4. Inseparability of Go and Stop in Inhibitory Control: Go Stimulus Discriminability Affects Stopping Behavior.

    Science.gov (United States)

    Ma, Ning; Yu, Angela J

    2016-01-01

    Inhibitory control, the ability to stop or modify preplanned actions under changing task conditions, is an important component of cognitive functions. Two lines of models of inhibitory control have previously been proposed for human response in the classical stop-signal task, in which subjects must inhibit a default go response upon presentation of an infrequent stop signal: (1) the race model, which posits two independent go and stop processes that race to determine the behavioral outcome, go or stop; and (2) an optimal decision-making model, which posits that observers decides whether and when to go based on continually (Bayesian) updated information about both the go and stop stimuli. In this work, we probe the relationship between go and stop processing by explicitly manipulating the discrimination difficulty of the go stimulus. While the race model assumes the go and stop processes are independent, and therefore go stimulus discriminability should not affect the stop stimulus processing, we simulate the optimal model to show that it predicts harder go discrimination should result in longer go reaction time (RT), lower stop error rate, as well as faster stop-signal RT. We then present novel behavioral data that validate these model predictions. The results thus favor a fundamentally inseparable account of go and stop processing, in a manner consistent with the optimal model, and contradicting the independence assumption of the race model. More broadly, our findings contribute to the growing evidence that the computations underlying inhibitory control are systematically modulated by cognitive influences in a Bayes-optimal manner, thus opening new avenues for interpreting neural responses underlying inhibitory control.

  5. Inseparability of Go and Stop in Inhibitory Control: Go Stimulus Discriminability Affects Stopping Behavior

    Directory of Open Access Journals (Sweden)

    Ning eMa

    2016-03-01

    Full Text Available Inhibitory control, the ability to stop or modify preplanned actions under changing task conditions, is an important component of cognitive functions. Two lines of models of inhibitory control have previously been proposed for human response in the classical stop-signal task, in which subjects must inhibit a default go response upon presentation of an infrequent stop signal: (1 the race model, which posits two independent go and stop processes that race to determine the behavioral outcome, go or stop; and (2 an optimal decision-making model, which posits that observers decides whether and when to go based on continually (Bayesian updated information about both the go and stop stimuli. In this work, we probe the relationship between go and stop processing by explicitly manipulating the discrimination difficulty of the go stimulus. While the race model assumes the go and stop processes are independent, and therefore go stimulus discriminability should not affect the stop stimulus processing, we simulate the optimal model to show that it predicts harder go discrimination results in a longer go reaction time (RT, a lower stop error rate, as well as a faster stop-signal RT. We then present novel behavioral data that validate these model predictions. The results thus favor a fundamentally inseparable account of go and stop processing, in a manner consistent with the optimal model, and contradicting the independence assumption of the race model. More broadly, our findings contribute to the growing evidence that the computations underlying inhibitory control are systematically modulated by cognitive influences in a Bayes-optimal manner, thus opening new avenues for interpreting neural responses underlying inhibitory control.

  6. Stopping, goal-conflict, trait anxiety and frontal rhythmic power in the stop-signal task.

    Science.gov (United States)

    Neo, Phoebe S-H; Thurlow, Jane K; McNaughton, Neil

    2011-12-01

    The medial right frontal cortex is implicated in fast stopping of an initiated motor action in the stop-signal task (SST). To assess whether this region is also involved in the slower behavioural inhibition induced by goal conflict, we tested for effects of goal conflict (when stop and go tendencies are balanced) on low-frequency rhythms in the SST. Stop trials were divided, according to the delays at which the stop signal occurred, into short-, intermediate-, and long-delay trials. Consistent with goal-conflict processing, intermediate-delay trials were associated with greater 7-8 Hz EEG power than short- or long-delay trials at medial right frontal sites (Fz, F4, and F8). At F8, 7-8 Hz power was linked to high trait anxiety and neuroticism. A separate 4-7 Hz power increase was also seen in stop, relative to go, trials, but this was independent of delay, was maximal at the central midline site Cz, and predicted faster stopping. Together with previous data on the SST, these results suggest that the right frontal region could be involved in multiple inhibition mechanisms. We propose a hierarchical model of the control of stopping that integrates the literature on the neural control of fast motor stopping with that on slower, motive-directed behavioural inhibition.

  7. Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families

    DEFF Research Database (Denmark)

    Hansen, Thomas van Overeem; Jønson, Lars; Albrechtsen, Anders

    2010-01-01

    Germ-line mutations in the tumour suppressor proteins BRCA1 and BRCA2 predispose to breast and ovarian cancer. We have recently identified a Greenlandic Inuit BRCA1 nucleotide 234T>G/c.115T>G (p.Cys39Gly) founder mutation, which at that time was the only disease-causing BRCA1/BRCA2 mutation...... identified in this population. Here, we describe the identification of a novel disease-causing BRCA1 nucleotide 4803delCC/c.4684delCC mutation in a Greenlandic Inuit with ovarian cancer. The mutation introduces a frameshift and a premature stop at codon 1572. We have also identified a BRCA1 nucleotide 249T......>A/c.130T>A (p.Cys44Ser) mutation in another Greenlandic individual with ovarian cancer. This patient share a 1-2 Mb genomic fragment, containing the BRCA1 gene, with four Danish families harbouring the same mutation, suggesting that the 249T>A/c.130T>A (p.Cys44Ser) mutation originates from a Danish...

  8. Cross-correlation Doppler global velocimetry (CC-DGV)

    Science.gov (United States)

    Cadel, Daniel R.; Lowe, K. Todd

    2015-08-01

    A flow velocimetry method, cross-correlation Doppler global velocimetry (CC-DGV), is presented as a robust, simplified, and high dynamic range implementation of the Doppler global/planar Doppler velocimetry technique. A sweep of several gigahertz of the vapor absorption spectrum is used for each velocity sample, with signals acquired from both Doppler-shifted scattered light within the flow and a non-Doppler shifted reference beam. Cross-correlation of these signals yields the Doppler shift between them, averaged over the duration of the scan. With presently available equipment, velocities from 0 ms-1 to over 3000 ms-1 can notionally be measured simultaneously, making the technique ideal for high speed flows. The processing routine is shown to be robust against large changes in the vapor pressure of the iodine cell, benefiting performance of the system in facilities where ambient conditions cannot be easily regulated. Validation of the system was performed with measurements of a model wind turbine blade boundary layer made in a 1.83 m by 1.83 m subsonic wind tunnel for which laser Doppler velocimetry (LDV) measurements were acquired alongside the CC-DGV results. CC-DGV uncertainties of ±1.30 ms-1, ±0.64 ms-1, and ±1.11 ms-1 were determined for the orthogonal stream-wise, transverse-horizontal, and transverse-vertical velocity components, and root-mean-square deviations of 2.77 ms-1 and 1.34 ms-1 from the LDV validation results were observed for Reynolds numbers of 1.5 million and 2 million, respectively. Volumetric mean velocity measurements are also presented for a supersonic jet, with velocity uncertainties of ±4.48 ms-1, ±16.93 ms-1, and ±0.50 ms-1 for the orthogonal components, and self-validation done by collapsing the data with a physical scaling.

  9. Photoshop CC top 100 simplified tips and tricks

    CERN Document Server

    Sholik, Stan

    2013-01-01

    Take your Photoshop skill set to the next level with these essential techniques If you're already familiar with Photoshop basics and are ready to learn some new tips, tricks, and techniques, then this is the book for you! Full-color, step-by-step instructions take you beyond the essentials and show you how to make the most of the newest features of Photoshop CC (Creative Cloud). Beautiful photos will inspire you to experiment with Photoshop's features, and numbered instructions make the techniques easy to learn. Encourages you to expand your skill set with creative, or

  10. CC-3 CAMAC crate controller for IBM PC

    International Nuclear Information System (INIS)

    Khare, A.N.; Ghodgaonkar, M.D.; Bairi, B.R.

    1991-01-01

    The specifications and implementation details of CAMAC Crate Controller CC-3 for IBM-PC compatible as a host computer, having capability to transfer high speed data with direct memory access (DMA) scheme and logic to execute CAMAC cycles directly from the crate controller, to implement the block algorithms specified in ANSI/IEEE Std. 683-1976 (Reaff-1981) are described. The maximum data transfer rate measured with 8 bit interface of PC-AT is 240K byte per second. This work is carried out under Seventh Five Year Plan Project on Modernisation of reactor Control Instrumentation and Development of CAMAC and Fastbus Instrumentation. (author). 9 refs., 5 figs., 4 appendixes

  11. Analysis specifications for the CC3 biosphere model biotrac

    Energy Technology Data Exchange (ETDEWEB)

    Szekely, J G; Wojciechowski, L C; Stephens, M E; Halliday, H A

    1994-12-01

    The CC3 (Canadian Concept, generation 3) model BIOTRAC (Biosphere Transport and Consequences) describes the movement in the biosphere of releases from an underground disposal vault, and the consequent radiological dose to a reference individual. Concentrations of toxic substances in different parts of the biosphere are also calculated. BIOTRAC was created specifically for the postclosure analyses of the Environmental Impact Statement that AECL is preparing on the concept for disposal of Canada`s nuclear fuel waste. The model relies on certain assumptions and constraints on the system, which are described by Davis et al. Accordingly, great care must be exercised if BIOTRAC is used for any other purpose.

  12. Biocide Susceptibility of Staphylococcus aureus CC398 and CC30 Isolates from Pigs and Identification of the Biocide Resistance Genes, qacG and qacC

    DEFF Research Database (Denmark)

    Seier-Petersen, Maria Amalie; Nielsen, Lene Nørby; Ingmer, Hanne

    2015-01-01

    Objectives: Methicillin-resistant Staphylococcus aureus (MRSA), in particular clonal complex (CC) 398, is increasingly found in livestock. Recently, MRSA CC30 was identified in Danish pigs. We determined the susceptibility of porcine S. aureus isolates of CC398 and CC30 to disinfectants used in pig......)-encoding virulence factors were investigated. Methods: Susceptibilities to biocides and antimicrobial agents of 79 porcine S. aureus isolates were determined by the microdilution method. Isolates comprised 21 methicillin-sensitive S. aureus (MSSA) and 40 MRSA isolates belonging to CC398 and 13 MSSA and 5 MRSA...... isolates belonging to CC30. The presence of quaternary ammonium compound (QAC) resistance efflux pumps was analyzed using an ethidium bromide accumulation assay. The presence of qac resistance genes in active efflux pump positive isolates was determined by whole-genome sequencing data. All isolates were...

  13. The control of deliberate waiting strategies in a stop-signal task

    Directory of Open Access Journals (Sweden)

    R.P. Sylwan

    2004-06-01

    Full Text Available To inhibit an ongoing flow of thoughts or actions has been largely considered to be a crucial executive function, and the stop-signal paradigm makes inhibitory control measurable. Stop-signal tasks usually combine two concurrent tasks, i.e., manual responses to a primary task (go-task are occasionally countermanded by a stimulus which signals participants to inhibit their response in that trial (stop-task. Participants are always instructed not to wait for the stop-signal, since waiting strategies cause the response times to be unstable, invalidating the data. The aim of the present study was to experimentally control the strategies of waiting deliberately for the stop-signal in a stop-task by means of an algorithm that measured the variation in the reaction times to go-stimuli on-line, and displayed a warning legend urging participants to be faster when their reaction times were more than two standard deviations of the mean. Thirty-four university students performed a stop-task with go- and stop-stimuli, both of which were delivered in the visual modality and were lateralized within the visual field. The participants were divided into two groups (group A, without the algorithm, vs group B, with the algorithm. Group B exhibited lower variability of reaction times to go-stimuli, whereas no significant between-group differences were found in any of the measures of inhibitory control, showing that the algorithm succeeded in controlling the deliberate waiting strategies. Differences between deliberate and unintentional waiting strategies, and anxiety as a probable factor responsible for individual differences in deliberate waiting behavior, are discussed.

  14. Bubble formation after a 20-m dive: deep-stop vs. shallow-stop decompression profiles

    NARCIS (Netherlands)

    Schellart, Nico A. M.; Corstius, Jan-Jaap Brandt; Germonpré, Peter; Sterk, Wouter

    2008-01-01

    OBJECTIVES: It is claimed that performing a "deep stop," a stop at about half of maximal diving depth (MDD), can reduce the amount of detectable precordial bubbles after the dive and may thus diminish the risk of decompression sickness. In order to ascertain whether this reduction is caused by the

  15. Quantification of C=C and C=O Surface Carbons in Detonation Nanodiamond by NMR

    Energy Technology Data Exchange (ETDEWEB)

    Cui, J -F; Fang, X -W; Schmidt-Rohr, K

    2014-05-08

    The ability of solid-state 13C NMR to detect and quantify small amounts of sp2-hybridized carbon on the surface of ~5 nm diameter nanodiamond particles is demonstrated. The C=C carbon fraction is only 1.1 ± 0.4% in pristine purified detonation nanodiamond, while a full single-layer graphitic or “bucky diamond” shell would contain ca. 25% of all C in a 5 nm diameter particle. Instead of large aromatic patches repeatedly proposed in the recent literature, sp3-hybridized CH and COH carbons cover most of the nanodiamond particle surface, accounting for ~5% each. C=O and COO groups also seen in X-ray absorption near-edge structure spectroscopy (XANES) but not detected in previous NMR studies make up ca. 1.5% of all C. They are removed by heat treatment at 800 °C, which increases the aromatic fraction. 13C{1H} NMR demonstrates that the various sp2-hybridized carbons are mostly not protonated, but cross-polarization shows that they are separated from 1H by only a few bond lengths, which proves that they are near the protonated surface. Together, the observed C–H, C–OH, C=O, and C=C groups account for 12–14% of all C, which matches the surface fraction expected for bulk-terminated 5 nm diameter diamond particles.

  16. The extent of the stop coannihilation strip

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, John [King' s College London, Theoretical Particle Physics and Cosmology Group, Department of Physics, London (United Kingdom); CERN, Theory Division, Geneva 23 (Switzerland); Olive, Keith A. [University of Minnesota, School of Physics and Astronomy, Minneapolis, MN (United States); University of Minnesota, William I. Fine Theoretical Physics Institute, School of Physics and Astronomy, Minneapolis, MN (United States); Zheng, Jiaming [University of Minnesota, School of Physics and Astronomy, Minneapolis, MN (United States)

    2014-07-15

    Many supersymmetric models such as the constrained minimal supersymmetric extension of the Standard Model (CMSSM) feature a strip in parameter space where the lightest neutralino χ is identified as the lightest supersymmetric particle, the lighter stop squark t{sub 1} is the next-to-lightest supersymmetric particle (NLSP), and the relic χ cold darkmatter density is brought into the range allowed by astrophysics and cosmology by coannihilation with the lighter stop squark t{sub 1} NLSP. We calculate the stop coannihilation strip in the CMSSM, incorporating Sommerfeld enhancement effects, and we explore the relevant phenomenological constraints and phenomenological signatures. In particular, we show that the t{sub 1} may weigh several TeV, and its lifetime may be in the nanosecond range, features that are more general than the specific CMSSM scenarios that we study in this paper. (orig.)

  17. The stopping rules for winsorized tree

    Science.gov (United States)

    Ch'ng, Chee Keong; Mahat, Nor Idayu

    2017-11-01

    Winsorized tree is a modified tree-based classifier that is able to investigate and to handle all outliers in all nodes along the process of constructing the tree. It overcomes the tedious process of constructing a classical tree where the splitting of branches and pruning go concurrently so that the constructed tree would not grow bushy. This mechanism is controlled by the proposed algorithm. In winsorized tree, data are screened for identifying outlier. If outlier is detected, the value is neutralized using winsorize approach. Both outlier identification and value neutralization are executed recursively in every node until predetermined stopping criterion is met. The aim of this paper is to search for significant stopping criterion to stop the tree from further splitting before overfitting. The result obtained from the conducted experiment on pima indian dataset proved that the node could produce the final successor nodes (leaves) when it has achieved the range of 70% in information gain.

  18. Comparison of clinical outcome and costs with CC + gonadotropins and gnrha + gonadotropins during Ivf/ICSI cycles.

    Science.gov (United States)

    Kovacs, Peter; Matyas, Szabolcs; Bernard, l Artur; Kaali, Steven G

    2004-06-01

    To compare clinical outcome and costs of CC + gonadotropins with GnRHa + gonadotropins during IVF/ICSI cycles. Clinical outcome and expenses of 382 CC + gonadotropin and 964 GnRHa + gonadotropin cycles were compared. Medication costs were calculated on the basis of the mean number of ampoules and the proportion of various gonadotropins. Costs per clinical pregnancy were calculated on the basis of expenses and clinical pregnancy rates. Women in the CC + gonadotropin group were younger, and had fewer follicles, oocytes, embryos, and embryos transferred. Clinical pregnancy rates were higher in the GnRHa group (35.9 % vs 26.2%, p costs per cycle were higher in the GnRHa group (US dollars 357 vs 248). Expenses per pregnancy however were lower in the GnRHa group (USdollars 4197 vs 5335 with IVF; USdollars 5590 vs 7244 with ICSI). When different age subgroups with similar baseline characteristics and stimulation parameters were compared, pregnancy rates were significantly higher in the GnRHa groups. Medication cost per cycle was higher in the GnRHa subgroups, and the expense per pregnancy was lower with GnRHa protocol. Cost per cycle is higher with GnRHa + gonadotropin. However, because of the better performance of the GnRHa + gonadotropin stimulation, the cumulative costs are reduced by the time a clinical pregnancy is achieved.

  19. Stopping Power Measurements: Implications in Nuclear Astrophysics

    International Nuclear Information System (INIS)

    Carmen Angulo; Thierry Delbar; Jean-Sebastien Graulich; Pierre Leleux

    1999-01-01

    The stopping powers of C, CH 2 , Al, Ni, and polyvinylchloride (PVC) for several light ions ( 9 Be, 11 B, 12 C, 14 N, 16 O, 19 F, 20 Ne) with an incident energy of 1 MeV/amu have been measured at the Louvain-la-Neuve cyclotron facility. Stopping powers are given relative to the one for 5.5 MeV 4 He ions with an uncertainty of less than 1%. We compare our results with two widely used semiempirical models and we discuss some implications in nuclear astrophysics studies

  20. Finding time, stopping the frenzy.

    Science.gov (United States)

    Perlow, L A

    1998-08-01

    While the deleterious consequences of long hours of work for individuals, families and communities have previously been documented, the assumption that long hours are necessary to get the work done, especially in a world where speed is becoming increasingly critical to corporate success, has prompted little challenge. So Leslie Perlow, an assistant professor of business at the University of Michigan, Ann Arbor, set out to explore the necessity for the seemingly endless workdays that so many postindustrial settings require. Her study of a group of software engineers at a Fortune 500 company--identified only as the Ditto Corp--is detailed in her book, Finding Time: How Corporations, Individuals, and Families Can Benefit from New Work Practices (Cornell University Press, 1997). Perlow's research reveals a "sad and all too common tale" of workers harried by competing demands, frequent interruptions and shifting deadlines. To meet the firm's expectations, the engineers she studied sacrificed home life, focused on individual tasks to the detriment of group goals and, in many cases, eventually lost any enthusiasm they'd had for working for the company. There has been some recognition that stress and burnout may be bad for a corporation as employees become less committed, decide to leave or get fired and that this kind of turnover can hurt the firm in the longer term. But Perlow documented the additional, and quite significant, shorter-term costs to the corporation of the current way of using time at work. What she found was a "vicious time cycle:" Time pressures led to a crisis mentality, which led to "individual heroics." That is, I'll do whatever it takes to do my job--even if it means interrupting you while you try to do yours. For the engineers Perlow studied, the lack of helping, the constant interruptions and the perpetual crises--clearly illustrated by the daily log that appears on page 34--made it harder to develop products. Ultimately, they worked long hours to

  1. Stopping light in its tracks

    Science.gov (United States)

    Eggleton, B. J.; Martijn de Sterke, C.; Slusher, R. E.; Krug, Peter A.; Sipe, J. E.

    1996-12-01

    To control the speed of a light pulse without absorbing its photons, or distorting its shape, is a challenging problem. However, this has been accomplished using fiber gratings, as part of a joint research program of the University of Sydney, the Australian Photonics Research Centre, Lucent Technologies, and the University of Toronto. The gratings are written in the optical fiber's core by directing a UV beam onto it via a periodic phase mask. Through a photochemical process still not well-understood, the periodic intensity pattern burns a permanent index of refraction change in the core.1-2 In our experiments, we use gratings with a period of about 350 nm chosen to reflect light at 1.05 u m and a length of 5.5 cm.3 Because the grating has over 150,000 periods, an index change of only 0.0003 is sufficient to limit the transmission to less than 30 dB on resonance. Essentially no light is transmitted by such a grating at the Bragg resonance; yet a nanometer away, light propagates through as if the grating were absent. As we tune away from resonance, the light's group velocity increases from zero to c/n (where c is the speed of light in a vacuum and n=1.46 is the refractive index of the core of the fiber), leading to a dispersion about 100,000 times larger than that of bare fiber. Gratings can thus slow down a pulse of light, but at the price of tearing it apart.4 At high light intensities a nonlinearly, with the index of refraction increasing with intensity.5 In the center of the pulse, where the intensity is the highest, the index is thus raised the most. Since regions of high index attract light, the nonlinearity acts as a "glue," counteracting the strong dispersive effects of the grating.

  2. Evaluating the Effects of Traffic on Driver Stopping and Turn Signal Use at a Stop Sign: A Systematic Replication

    Science.gov (United States)

    Lebbon, Angela R.; Austin, John; Van Houten, Ron; Malenfant, Louis E.

    2007-01-01

    The current analyses of observational data found that oncoming traffic substantially affected driver stopping patterns and turn signal use at the target stop sign. The percentage of legal stops and turn signal use by drivers in the presence and absence of traffic was analyzed using a multi-element design. The results showed that legal stops were…

  3. Seismic stops for nuclear power plants

    International Nuclear Information System (INIS)

    Cloud, R.L.; Leung, J.S.M.; Anderson, P.H.

    1989-01-01

    In the regulated world of nuclear power, the need to have analytical proof of performance in hypothetical design-basis events such as earth quakes has placed a premium on design configurations that are mathematically tractable and easily analyzed. This is particularly true for the piping design. Depending on how the piping analyses are organized and on how old the plant is, there may be from 200 to 1000 separate piping runs to be designed, analyzed, and qualified. In this situation, the development of snubbers seemed like the answer to a piping engineer's prayer. At any place where seismic support was required but thermal motion had to be accommodated, a snubber could be specified. But, as experience has now shown, the program was solved only on paper. This article presents an alternative to conventional snubbers. These new devices, termed Seismic Stops are designed to replace snubbers directly and look like snubbers on the outside. But their design is based on a completely different principle. The original concept has adapted from early seismic-resistant pipe support designs used on fossil power plants in California. The fundamental idea is to provide a space envelope in which the pipe can expand freely between the hot and cold positions, but cannot move outside the envelope. Seismic Stops are designed to transmit any possible impact load, as would occur in an earthquake, away from the pipe itself to the Seismic Stop. The Seismic Stop pipe support is shown

  4. Are Stopped Strings Preferred in Sad Music?

    Directory of Open Access Journals (Sweden)

    David Huron

    2017-01-01

    Full Text Available String instruments may be played either with open strings (where the string vibrates between the bridge and a hard wooden nut or with stopped strings (where the string vibrates between the bridge and a performer's finger pressed against the fingerboard. Compared with open strings, stopped strings permit the use of vibrato and exhibit a darker timbre. Inspired by research on the timbre of sad speech, we test whether there is a tendency to use stopped strings in nominally sad music. Specifically, we compare the proportion of potentially open-to-stopped strings in a sample of slow, minor-mode movements with matched major-mode movements. By way of illustration, a preliminary analysis of Samuel Barber's famous Adagio from his Opus 11 string quartet shows that the selected key (B-flat minor provides the optimum key for minimizing open string tones. However, examination of a broader controlled sample of quartet movements by Haydn, Mozart and Beethoven failed to exhibit the conjectured relationship. Instead, major-mode movements were found to avoid possible open strings more than slow minor-mode movements.

  5. How to Stop Biting Your Nails

    Medline Plus

    Full Text Available ... gloves to prevent biting. Replace the nail-biting habit with a good habit: When you feel like biting your nails, try ... recommend taking a gradual approach to break the habit. Try to stop biting one set of nails, ...

  6. Car Stopping Distance on a Tabletop

    Science.gov (United States)

    Haugland, Ole Anton

    2013-01-01

    Stopping distances in car braking can be an intriguing topic in physics teaching. It illustrates some basic principles of physics, and sheds valuable light on students' attitude towards aggressive driving. Due to safety considerations, it can be difficult to make experiments with actual car braking. (Contains 2 figures.)

  7. Bystanders Are the Key to Stopping Bullying

    Science.gov (United States)

    Padgett, Sharon; Notar, Charles E.

    2013-01-01

    Bullying is the dominance over another. Bullying occurs when there is an audience. Peer bystanders provide an audience 85% of instances of bullying. If you remove the audience bullying should stop. The article is a review of literature (2002-2013) on the role of bystanders; importance of bystanders; why bystanders behave as they do; resources to…

  8. Brownian Optimal Stopping and Random Walks

    International Nuclear Information System (INIS)

    Lamberton, D.

    2002-01-01

    One way to compute the value function of an optimal stopping problem along Brownian paths consists of approximating Brownian motion by a random walk. We derive error estimates for this type of approximation under various assumptions on the distribution of the approximating random walk

  9. Approximations for stop-loss reinsurance premiums

    NARCIS (Netherlands)

    Reijnen, Rajko; Albers, Willem/Wim; Kallenberg, W.C.M.

    2005-01-01

    Various approximations of stop-loss reinsurance premiums are described in literature. For a wide variety of claim size distributions and retention levels, such approximations are compared in this paper to each other, as well as to a quantitative criterion. For the aggregate claims two models are

  10. Stop-loss premiums under dependence

    NARCIS (Netherlands)

    Albers, Willem/Wim

    1999-01-01

    Stop-loss premiums are typically calculated under the assumption that the insured lives in the underlying portfolio are independent. Here we study the effects of small departures from this assumption. Using Edgeworth expansions, it is made transparent which configurations of dependence parameters

  11. [Comporison Sduty of Microstructure by Metallographicalk on the Polarized Light and Texture by XRD of CC 5083 and CC 5182 Aluminium Alloy after Cold Rolling and Recrystallization].

    Science.gov (United States)

    Chen, Ming-biao; Li, Yong-wei; Tan, Yuan-biao; Ma, Min; Wang, Xue-min; Liu, Wen-chang

    2015-03-01

    At present the study of relation between microstructure, texture and performance of CC 5083 aluminium alloy after cold tolling and recrystallization processes is still finitude. So that the use of the CC 5083 aluminium alloy be influenced. Be cased into electrical furnace, hot up with unlimited speed followed the furnace hot up to different temperature and annealed 2h respectively, and be cased into salt-beth furnace, hot up quickly to different temperature and annealed 30 min respectively for CC 5083 and CC 5182 aluminum alloy after cold roling with 91.5% reduction. The microstructure be watched use metallographic microscope, the texture be inspected by XRD. The start temperature of recrystallization and grain grow up temperature within annealing in the electric furnace of CC 5083 aluminum alloy board is 343 degrees C, and the shap of grain after grow up with long strip (the innovation point ); The start temperature of recrystallization within annealling in the salt bath furnace of CC 5083 is 343 degrees C. The start temperature and end temperature of recrystallization within annealling of CC 5083 and CC 5182 aluminum alloy is 371 degrees C. The grain grow up outstanding of cold rooled CC 5152 aluminum alloy after annealed with 454 degrees C in the electric furnace and salt bath furnace. The start temperature of grain grow up of CC 5083 alluminurn alloy annealed in the electric furnace and salt bath furnace respectively is higher than the start temperature of grain grow up of CC 5182 alluminum alloy annealed in the electric furnace and salt bath furnace respectively. The strat temperature of recrystallization grain grow up is higher than which annealled with other three manner annealing process. The recrystallization temperature of CC 5182 annealed in the salt bath furnace is higher than which annealed in the electric furnace. The recrystallization temperature of the surface layer of CC 5083 and CC 5182 aluminum alloy is higher than the inner layer (the innovation

  12. Ab initio electronic stopping power in materials

    International Nuclear Information System (INIS)

    Shukri, Abdullah-Atef

    2015-01-01

    The average energy loss of an ion per unit path length when it is moving through the matter is named the stopping power. The knowledge of the stopping power is essential for a variety of contemporary applications which depend on the transport of ions in matter, especially ion beam analysis techniques and ion implantation. Most noticeably, the use of proton or heavier ion beams in radiotherapy requires the knowledge of the stopping power. Whereas experimental data are readily available for elemental solids, the data are much more scarce for compounds. The linear response dielectric formalism has been widely used in the past to study the electronic stopping power. In particular, the famous pioneering calculations due to Lindhard evaluate the electronic stopping power of a free electron gas. In this thesis, we develop a fully ab initio scheme based on linear response time-dependent density functional theory to predict the impact parameter averaged quantity named the random electronic stopping power (RESP) of materials without any empirical fitting. The purpose is to be capable of predicting the outcome of experiments without any knowledge of target material besides its crystallographic structure. Our developments have been done within the open source ab initio code named ABINIT, where two approximations are now available: the Random-Phase Approximation (RPA) and the Adiabatic Local Density Approximation (ALDA). Furthermore, a new method named 'extrapolation scheme' have been introduced to overcome the stringent convergence issues we have encountered. These convergence issues have prevented the previous studies in literature from offering a direct comparison to experiment. First of all, we demonstrate the importance of describing the realistic ab initio electronic structure by comparing with the historical Lindhard stopping power evaluation. Whereas the Lindhard stopping power provides a first order description that captures the general features of the

  13. Synthesis of chondroitin sulfate CC and DD tetrasaccharides and interactions with 2H6 and LY111.

    Science.gov (United States)

    Matsushita, Kenya; Nakata, Tomomi; Takeda-Okuda, Naoko; Nadanaka, Satomi; Kitagawa, Hiroshi; Tamura, Jun-Ichi

    2018-03-01

    We synthesized the biotinylated chondroitin sulfate tetrasaccharides CS-CC [-3)βGalNAc6S(1-4)βGlcA(1-] 2 and CS-DD [-3)βGalNAc6S(1-4)βGlcA2S(1-] 2 which possess sulfate groups at O-6 of GalNAc and an additional sulfate group at O-2 of GlcA, respectively. We also analyzed interactions among CS-CC and CS-DD and the antibodies 2H6 and LY111, both of which are known to bind with CS-A, while CS-DD was shown for the first time to bind with both antibodies. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. Optimization of labelling PSMA-HBED-CC peptide with 68Ga

    International Nuclear Information System (INIS)

    Alcarde, Lais F.; Dias, Luis A.P.; Massicano, Adriana V.F.; Mengatti, Jair; Araujo, Elaine B. de

    2015-01-01

    Early detection of metastases or recurrent prostate cancer (PC) lesions is of clinical relevance in terms of clinical staging, prognosis and therapy management. When PC is not treated, it is potentially lethal. Clinical methods for diagnosis of PC include the dosage of prostatic specific antigen (PSA) and the rectal touch. Unfortunately, these initial procedures are not specific for PC detection. The level of PSA, in about 20 to 30% of the cases is high, due to benign pathologies, that result in false positive and unneeded biopsy. The prostatic specific membrane antigen (PSMA) is a type II transmembrane glycoprotein and differs from the PSA that is a free protein in blood. High levels of PSMA are observed in almost all prostatic pathologies and low levels were observed in brain, kidneys, salivary glands and small intestine. This fact stimulated the development of PSMA inhibitor molecules that could be used as a vector for imaging tumor agents and that could perfuse in the tumor microvasculature. Recent studies suggest that the chelator HBED-CC contributes intrinsically for the labelling of the PSMA inhibitor peptide based in urea - Glu-urea-Lys (Ahx) – to the pharmacophore group. This work describes the study of labelling conditions of PSMA-HBED-CC with 68 Ga and determined the ideal conditions to obtaining the high radiochemical purity (≥ 95%) and stability, without final purification, and stimulates the in vitro and in vivo evaluation to determine the potential of the radiopharmaceutical for clinical application. (author)

  15. MP Finance Group CC (In Liquidation) V C: SARS: Adding to the ...

    African Journals Online (AJOL)

    Southern African Business Review. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 19, No 1 (2015) >. Log in or Register to get access to full text downloads.

  16. MP Finance Group CC (In Liquidation) V C: SARS: Adding to the ...

    African Journals Online (AJOL)

    This article analyses the interpretation of the phrase “received by, accrued to or in favour of” in the gross income definition of the Income Tax Act, as applied to illegal receipts. During the last few decades, South Africans have been victims of a number of Ponzi-type schemes. In MP Finance, the Supreme Court of Appeal ...

  17. Stop feeling: Inhibition of emotional interference following stop-signal trials

    OpenAIRE

    Eyal eKalanthroff; Noga eCohen; Avishai eHenik

    2013-01-01

    Although a great deal of literature has been dedicated to the mutual links between emotion and the selective attention component of executive control, there is very little data regarding the links between emotion and the inhibitory component of executive control. In the current study we employed an emotional stop-signal task in order to examine whether emotion modulates and is modulated by inhibitory control. Results replicated previous findings showing reduced inhibitory control [longer stop...

  18. Simulations of enhanced ion stopping power experiments

    International Nuclear Information System (INIS)

    Mehlhorn, T.A.; Maenchen, J.E.; Olsen, J.N.; Johnson, D.J.

    1984-01-01

    As the material in an ICF target is heated and ionized by an intense ion beam, the ion stopping power changes from that of neutral atoms. This changes the energy deposition characteristics of the ion beam and thereby can profoundly influence the target dynamics. An accurate ion energy deposition model is important for designing ICF targets that perform in an optimal fashion. An experiment to measure a time-resolved ion stopping power history in a partially ionized target is being fielded on the PROTO I accelerator at Sandia Labs. This experiment utilizes a voltage ramped Thomson parabola to provide a time-history of the ion energy incident upon and exiting from a cylindrical target foil

  19. Measurement of stopping power of light ions

    International Nuclear Information System (INIS)

    Sakamoto, Naoki

    1981-01-01

    The stopping power of light ions penetrating various materials has been measured. The data of proton stopping power and the mean ionization potentials are presented. The experiments were made by using the 6.75 MeV protons from a cyclotron and the protons in the energy range from 3 to 9 MeV from a tandem Van de Graaff. The windows with and without sample-foils were rotated in front of a semiconductor detector, and the measured energy loss and the thickness of the sample foils were used to estimate the energy loss at the mean energy of protons in the samples. The analyses were made by considering the inner shell correction, Z 1 3 correction and the Bloch correction. The mean ionization potentials were derived from the data. (Kato, T.)

  20. Nuclear stopping power at high energies

    International Nuclear Information System (INIS)

    Date, S.; Gyulassy, M.; Sumiyoshi, H.

    1985-03-01

    Recent p + A → p + X data are analyzed within the context of the multi-chain and additive quark models. We deduce the average energy loss of a baryon as a function of distance traversed in nuclear matter. Consistency of the multi-chain model is checked by comparing the predictions for p + A → π +- + X with data. We discuss the space-time development of baryon stopping and show how longitudinal growth limits the energy deposition per unit length. Predictions are made for the proton spectra to be measured in nucleus-nucleus collisions at CERN and BNL. Finally, we conclude that the stopping domain for central collisions of heavy ions extends up to center of mass kinetic energies KEsub(em) asymptotically equals 3 +- 1 AGev. (author)

  1. Single start multiple stop time digitizer

    International Nuclear Information System (INIS)

    Deshpande, P.A.; Mukhopadhyay, P.K.; Gopalakrishnan, K.R.

    1997-01-01

    A single start multiple stop time digitizer has been developed which can digitize the time between a start pulse and multiple stop pulses. The system has been designed as a PC add on card. The resolution of the instrument is 10 nSecs and the maximum length of time that it can measure is 1.28 milliseconds. Apart from time digitization, it can also resolve the height of the incoming pulses into 64 levels. After each input pulse the system dead time is less than 300 nSecs. The driver software for this card has been developed on DOS platform. It uses graphical user interface to provide a user friendly environment. The system is intended to be used in time of flight mass spectroscopy experiments. It can also be used for time of flight experiments in nuclear physics. (author). 2 figs

  2. Neutronic Analysis of the RSG-GAS Compact Core without CIP Silicide 3.55 g U/cc and 4.8 g U/cc

    International Nuclear Information System (INIS)

    Jati S; Lily S; Tukiran S

    2004-01-01

    Fuel conversion from U 3 O 8 -Al to U 3 Si 2 -Al 2.96 g U/cc density in the RSG-GAS core had done successfully step by step since 36 th core until 44 th core. So that, since the 45 th core until now (48 th core) had been using full of silicide 2.96 g U/cc. Even though utilization program of silicide fuel with high density (3.55 g U/cc and 4.8 g U/cc) and optimize operation of RSG-GAS core under research. Optimalitation of core with increasing operation cycle have been analyzing about compact core. The mean of compact core is the RSG-GAS core with decrease number of IP or CIP position irradiation. In this research, the neutronic calculation to cover RSG-GAS core and RSG-GAS core without CIP that are using U 3 Si 2 -Al 2.96 g U/cc, 3.55 g U/cc and 4.8 g U/cc had done. Two core calculation done at 15 MW power using SRAC-ASMBURN code. The calculation result show that fuel conversion from 2.96 g U/cc density to 3.55 g U/cc and 4.8 g U/cc will increasing cycle length for both RSG-GAS core and RSG-GAS compact core without CIP. However, increasing of excess reactivity exceeded from nominal value of first design that 9.2%. Change of power peaking factor is not show significant value and still less than 1.4. Core fuelled with U 3 Si 2 -Al 4.8 g U/cc density have maximum discharge burn-up which exceeded from licensing value (70%). RSG-GAS compact core without CIP fuelled U 3 Si 2 -Al 2.96 g U/cc have longer cycle operation then RSG-GAS core and fulfil limitation neutronic parameter at the first design value. (author)

  3. Thermal-mechanical and isothermal fatigue of IN 792 CC

    International Nuclear Information System (INIS)

    Beck, T.; Pitz, G.; Lang, K.-H.; Loehe, D.

    1997-01-01

    The cyclic deformation and lifetime behaviour of the cast Ni-base superalloy IN 792 CC was investigated both under thermal-mechanical fatigue (TMF) and isothermal fatigue (IF) conditions. During TMF the phase relations between temperature and mechanical strain were in-phase and out-of-phase, respectively. For both phase relations a similar cyclic deformation behaviour is observed. In all cases out-of-phase TMF causes tensile mean stresses, whereas in-phase TMF leads to compressive mean stresses. At T max below 800 C out-of-phase cycling results in smaller lifetimes than in-phase loading. In spite of the rather high compressive mean stresses developing at T max above 800 C, at these temperatures in-phase loading causes shorter lifetimes than out-of-phase TMF. This effect is due to the different damage mechanisms caused by in-phase and out-of-phase loadings: at higher T max considerable intergranular damage caused by in-phase loading reduces the lifetime below the respective values measured during out-of-phase TMF, after which no intergranular damage could be detected. A comparison of the TMF data with the cyclic deformation and lifetime behaviour under IF conditions shows that the material's reactions under TMF cannot be assessed satisfactorily by the results obtained from isothermal fatigue tests. (orig.)

  4. Analysis specifications for the CC3 geosphere model GEONET

    International Nuclear Information System (INIS)

    Melnyk, T.W.

    1995-04-01

    AECL is assessing a concept for disposing of Canada's nuclear fuel waste in a sealed vault deep in plutonic rock of the Canadian Shield. A computer program has been developed as an analytical tool for the postclosure assessment case study, a system model, CC3 (Canadian Concept, generation 3), has been developed to describe a hypothetical disposal system. This system model includes separate models for the engineered barriers within the disposal vault, the geosphere in which the vault is emplaced, and the biosphere in the vicinity of any discharge zones. The system model is embedded within a computer code SYVAC3, (SYstems Variability Analysis Code, generation 3), which takes parameter uncertainty into account by repeated simulation of the system. GEONET (GEOsphere NETwork) is the geosphere model component of this system model. It simulates contaminant transport from the vault to the biosphere along a transport network composed of one-dimensional transport segments that are connected together in three-dimensional space. This document is a set of specifications for GEONET that were developed over a number of years. Improvements to the code will be based on revisions to these specifications. The specifications consist of a model synopsis, describing all the relevant equations and assumptions used in the model, a set of formal data flow diagrams and minispecifications, and a data dictionary. (author). 26 refs., 20 figs

  5. Finite Optimal Stopping Problems: The Seller's Perspective

    Science.gov (United States)

    Hemmati, Mehdi; Smith, J. Cole

    2011-01-01

    We consider a version of an optimal stopping problem, in which a customer is presented with a finite set of items, one by one. The customer is aware of the number of items in the finite set and the minimum and maximum possible value of each item, and must purchase exactly one item. When an item is presented to the customer, she or he observes its…

  6. Electron mass stopping power in H2

    Science.gov (United States)

    Fursa, Dmitry V.; Zammit, Mark C.; Threlfall, Robert L.; Savage, Jeremy S.; Bray, Igor

    2017-08-01

    Calculations of electron mass stopping power (SP) of electrons in H2 have been performed using the convergent close-coupling method for incident electron energies up to 2000 eV. Convergence of the calculated SP has been established by increasing the size of the close-coupling expansion from 9 to 491 states. Good agreement was found with the SP measurements of Munoz et al. [Chem. Phys. Lett. 433, 253 (2007), 10.1016/j.cplett.2006.10.114].

  7. The TRIUMF stopped π-μ channel

    International Nuclear Information System (INIS)

    Al-Qazzaz, N.M.M.; Beer, G.A.; Mason, G.R.

    1980-01-01

    The TRIUMF π-μ channel (M9) is described and the measured optical paramters are compared with design values. Measured beam characteristics of pions and muons for several different momenta are reported for protons incident on Be and Cu production targets. A beam of cloud muons at the channel momentum, from π decays near the production target, has been obtained having a high stopping density and small spot size. (auth)

  8. Relativistic theory of stopping for heavy ions

    International Nuclear Information System (INIS)

    Lindhard, J.; So/rensen, A.H.

    1996-01-01

    We calculate the electronic stopping power and the corresponding straggling for ions of arbitrary charge number, penetrating matter at any relativistic energy. The stopping powers are calculated by a simple method. Its starting point is the deviation of the precise theory from first-order quantum perturbation. We show that this deviation can be expressed in terms of the transport cross section, σ tr , for scattering of a free electron by the ion. In the nonrelativistic case the deviation is precisely the Bloch correction to Bethe close-quote s formula; we look into the nonrelativistic case in order to clarify both some features of our method and a seeming paradox in Rutherford scattering. The corresponding relativistic correction is obtained from σ tr for scattering of a Dirac electron in the ion potential. Here, the major practical advantage of the method shows up; we need not find the scattering distribution, but merely a single quantity, σ tr , determined by differences of successive phase shifts. For a point nucleus our results improve and extend those of Ahlen. Our final results, however, are based on atomic nuclei with standard radii. Thereby, the stopping is changed substantially already for moderate values of γ=(1-v 2 /c 2 ) -1/2 . An asymptotic saturation in stopping is obtained. Because of finite nuclear size, recoil corrections remain negligible at all energies. The average square fluctuation in energy loss is calculated as a simple fluctuation cross section for a free electron. The fluctuation in the relativistic case is generally larger than that of the perturbation formula, by a factor of ∼2 endash 3 for heavy ions. But the finite nuclear radius leads to a strong reduction at high energies and the elimination of the factor γ 2 belonging to point nuclei. copyright 1996 The American Physical Society

  9. Spectroscopy of hypernuclei with stopped kaons

    International Nuclear Information System (INIS)

    Tamura, H.; Brueckner, W.; Doebbeling, H.

    1987-09-01

    Pion momentum spectra from K - absorption at rest on various nuclear targets were measured by means of a magnetic spectrometer with wide momentum range (100 ∼ 300 MeV/c). The ground state of Σ - hypernucleus, if well bound with a narrow width, is expected to be populated in 12 C(stopped K - , π + ) inclusive (untagged) spectrum, but such a peak was not observed. The spectrum is compared with the DWIA calculations by Morimatsu and Yazaki, indicating that the depth of the nuclear potential of Σ - is shallower than 12 MeV, and that its imaginary part is larger than 5 MeV if the potential depth is about 10 MeV. In the 12 C(stopped K - , π - ) spectrum, the ground state ((p3/2) n -1 (s1/2) Λ ) and the excited states ((p3/2) n -1 (p) Λ ) of Λ 12 C were observed, and their formation probabilities were roughly in agreement with the results of DWIA calculations. In the π - spectra on 12 C, 9 Be, and 7 Li targets a distinct peak was observed at 132.1 ± 0.7 MeV/c. It is ascribed to π - from the mesic decay of Λ 4 H; Λ 4 H → 4 He π - . The formation probability of Λ 4 H on C, Be, or Li target is much larger than those of the discrete states of Λ 12 C via the direct (stopped K - , π - ) reaction. (author)

  10. Oxidative C-C bond cleavage of 1,2-diols by silver(II)

    International Nuclear Information System (INIS)

    Kumar, A.

    1981-01-01

    Oxidation of ethylene glycol and related compounds by Ag(II) has been investigated. Complexation of these substrates by Ag(II) precedes their oxidation. Oxidation occurs through electron transfer from an OH group to the Ag(II) within the complex resulting in the formation of alkoxyl-type radicals. The radicals thus formed undergo β-scission to give cleavage products. For ethylene glycol a complexation rate 1.3 x 10 6 M -1 s -1 and oxidation rate approx. 3 x 10 3 s -1 were observed. A general trend for the type of the substrates which would undergo C-C bond scission by Ag(II) is discussed

  11. INTERSECTION DETECTION BASED ON QUALITATIVE SPATIAL REASONING ON STOPPING POINT CLUSTERS

    Directory of Open Access Journals (Sweden)

    S. Zourlidou

    2016-06-01

    Full Text Available The purpose of this research is to propose and test a method for detecting intersections by analysing collectively acquired trajectories of moving vehicles. Instead of solely relying on the geometric features of the trajectories, such as heading changes, which may indicate turning points and consequently intersections, we extract semantic features of the trajectories in form of sequences of stops and moves. Under this spatiotemporal prism, the extracted semantic information which indicates where vehicles stop can reveal important locations, such as junctions. The advantage of the proposed approach in comparison with existing turning-points oriented approaches is that it can detect intersections even when not all the crossing road segments are sampled and therefore no turning points are observed in the trajectories. The challenge with this approach is that first of all, not all vehicles stop at the same location – thus, the stop-location is blurred along the direction of the road; this, secondly, leads to the effect that nearby junctions can induce similar stop-locations. As a first step, a density-based clustering is applied on the layer of stop observations and clusters of stop events are found. Representative points of the clusters are determined (one per cluster and in a last step the existence of an intersection is clarified based on spatial relational cluster reasoning, with which less informative geospatial clusters, in terms of whether a junction exists and where its centre lies, are transformed in more informative ones. Relational reasoning criteria, based on the relative orientation of the clusters with their adjacent ones are discussed for making sense of the relation that connects them, and finally for forming groups of stop events that belong to the same junction.

  12. Help Stop the Flu | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... page please turn Javascript on. Feature: Flu Shot Help Stop the Flu Past Issues / Winter 2011 Table ... CDC recommends that Americans do the following to help stop the flu: Cover nose and mouth with ...

  13. CDC Vital Signs: New Hope for Stopping HIV

    Science.gov (United States)

    ... 27 MB] Read the MMWR Science Clips New Hope for Stopping HIV Testing and Medical Care Save ... acquired immunodeficiency syndrome) and early death. There's new hope today for stopping HIV in the US. Medicines ( ...

  14. Optimal Stopping and Policyholder Behaviour in Life Insurance

    DEFF Research Database (Denmark)

    Gad, Kamille Sofie Tågholt

    . Below, I give a brief overview of the results of each of the chapters. A more thorough overview is presented in Chapter 1. In Chapter 2 we consider a general geometric Lévy process and solve the non-linear optimal stopping problem of maximizing the variance at the stopping time. For solving this problem...... we solve an auxiliary quadratic optimal stopping problem. We show that the solution to maximizing variance depends on whether randomized stopping times are included in the set of stopping times we maximize over. For some problems the inclusion of randomized stopping times increase the value function...... and for some it does not. Even when the value function is not affected by inclusion of randomized stopping times, a solution may be easier to identify when they are. In Chapter 3 we consider the non-linear optimal stopping problem of maximizing the mean minus a positive constant times the variance...

  15. JACoW SIP4C/C++ at CERN - Status and lessons learned

    CERN Document Server

    Jensen, Steen; Dworak, Andrzej; Gourber-Pace, Marine; Hoguin, Frederic; Lauener, Joel; Locci, Frank; Sigerud, Katarina; Sliwinski, Wojciech

    2018-01-01

    After 4 years of promoting the Software Improvement Process for C/C++ (SIP4C/C++) initiative at CERN, we describe the current status for tools and procedures along with how they have been integrated into our environment. Based on feedback from four project teams, we present reasons for and against their adoption. Finally, we show how SIP4C/C++ has improved development and delivery processes as well as the first-line support of delivered products.

  16. Intelligent Bus Stops in the Flexible Bus Systems

    OpenAIRE

    Razi Iqbal; Muhammad Usman Ghani

    2014-01-01

    The purpose of this paper is to discuss Intelligent Bus Stops in a special Demand Responsive Transit (DRT), the Flexible Bus System. These Intelligent Bus Stops are more efficient and information rich than Traditional Bus Stops. The real time synchronization of the Flexible Bus System makes it unique as compared to Traditional Bus Systems. The Main concern is to make Bus Stops intelligent and information rich. Buses are informed about the no. of passengers waiting at the upcoming ...

  17. Development and psychometric properties of the Suicidality: Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents.

    Science.gov (United States)

    Flamarique, I; Santosh, P; Zuddas, A; Arango, C; Purper-Ouakil, D; Hoekstra, P J; Coghill, D; Schulze, U; Dittmann, R W; Buitelaar, J K; Lievesley, K; Frongia, R; Llorente, C; Méndez, I; Sala, R; Fiori, F; Castro-Fornieles, J

    2016-12-13

    To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. As part of the EU project 'Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs) for children and adolescents and for proxy reports by parents and clinicians in order to assess suicidality. Based on a literature review, expert panels and focus groups of patients, we developed the items of the STOP Suicidality Assessment Scale (STOP-SAS) in Spanish and English, translated it into four more languages, and optimized it for web-based presentation using the HealthTracker TM platform. Of the total 19 questions developed for the STOP-SAS, four questions that assess low-level suicidality were identified as screening questions (three of them for use with children, and all four for use with adolescents, parents and clinicians). A total of 395 adolescents, 110 children, 637 parents and 716 clinicians completed the questionnaire using the HealthTracker TM , allowing us to evaluate the internal consistency and convergent validity of the STOP-SAS with the clinician-rated Columbia Suicide Severity Rating Scale (C-SSRS). Validity was also assessed with the receiver operating characteristic (ROC) area of the STOP-SAS with the C-SSRS. The STOP-SAS comprises 19 items in its adolescent, parent, and clinician versions, and 14 items in its children's version. Good internal consistency was found for adolescents (Cronbach's alpha: 0.965), children (Cronbach's alpha: 0.922), parents (Cronbach's alpha: 0.951) and clinicians (Cronbach's alpha: 0.955) versions. A strong correlation was found between the STOP-SAS and the C-SSRS for adolescents (r:0.670), parents (r:0.548), clinicians (r:0.863) and children (r:0.654). The ROC area was good for clinicians' (0.917), adolescents' (0.834) and parents' (0.756) versions but only fair (0.683) for children's version. The STOP-SAS is a comprehensive, web

  18. Measurements of psi -> K-Lambda(Xi)over-bar(+) + c.c. and psi -> gamma K-Lambda(Xi)over-bar(+) + c.c.

    NARCIS (Netherlands)

    Ablikim, M.; Achasov, M. N.; Ai, X. C.; Albayrak, O.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Ferroli, R. Baldini; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, H. Y.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, X.; Chen, X. R.; Chen, Y. B.; Cheng, H. P.; Chu, X. K.; Cibinetto, G.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; De Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Duan, S. X.; Duan, P. F.; Fan, J. Z.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Fava, L.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. Y.; Gao, Y.; Gao, Z.; Garzia, I.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, Y.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Han, Y. L.; Hao, X. Q.; Harris, F. A.; He, K. L.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. M.; Huang, G. S.; Huang, H. P.; Huang, J. S.; Huang, X. T.; Huang, Y.; Hussain, T.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. L.; Jiang, L. W.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kuehn, W.; Kupsc, A.; Lai, W.; Lange, J. S.; Lara, M.; Larin, P.; Leng, C.; Li, C. H.; Li, Cheng; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, Jin; Li, K.; Li, K.; Li, Lei; Li, P. R.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. M.; Li, X. N.; Li, X. Q.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B. J.; Liu, C. X.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. H.; Liu, H. H.; Liu, H. M.; Liu, J.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, X. X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, R. Q.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. N.; Ma, X. Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales, C. Morales; Moriya, K.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Pu, Y. N.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, N.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ren, H. L.; Ripka, M.; Rong, G.; Ruan, X. D.; Santoro, V.; Sarantsev, A.; Savrie, M.; Schoenning, K.; Schumann, S.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Toth, D.; Ullrich, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q. J.; Wang, S. G.; Wang, W.; Wang, X. F.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Weber, T.; Wei, D. H.; Wei, J. B.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, Z.; Xia, L. G.; Xia, Y.; Xiao, D.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. X.; Yang, L.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yin, J. H.; Yu, B. X.; Yu, C. X.; Yu, H. W.; Yu, J. S.; Yuan, C. Z.; Yuan, W. L.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. H.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. T.; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. W.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, Li; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.

    2015-01-01

    Using a sample of 1.06 x 10(8) psi(3686) events produced in e(+)e(-) collisions at root s = 3.686 GeV and collected with the BESIII detector at the BEPCII collider, we present studies of the decays psi(3686) -> K-Lambda(Xi) over bar (+) + c.c. and psi(3686) -> gamma K-Lambda(Xi) over bar (+) + c.c.

  19. Start-Stop Test Procedures on the PEMFC Stack Level

    DEFF Research Database (Denmark)

    Mitzel, Jens; Nygaard, Frederik; Veltzé, Sune

    The test is addressed to investigate the influence on stack durability of a long stop followed by a restart of a stack. Long stop should be defined as a stop in which the anodic compartment is fully filled by air due to stack leakages. In systems, leakage level of the stack is low and time to fil...

  20. Biobjective Optimization and Evaluation for Transit Signal Priority Strategies at Bus Stop-to-Stop Segment

    Directory of Open Access Journals (Sweden)

    Rui Li

    2016-01-01

    Full Text Available This paper proposes a new optimization framework for the transit signal priority strategies in terms of green extension, red truncation, and phase insertion at the stop-to-stop segment of bus lines. The optimization objective is to minimize both passenger delay and the deviation from bus schedule simultaneously. The objective functions are defined with respect to the segment between bus stops, which can include the adjacent signalized intersections and downstream bus stops. The transit priority signal timing is optimized by using a biobjective optimization framework considering both the total delay at a segment and the delay deviation from the arrival schedules at bus stops. The proposed framework is evaluated using a VISSIM model calibrated with field traffic volume and traffic signal data of Caochangmen Boulevard in Nanjing, China. The optimized TSP-based phasing plans result in the reduced delay and improved reliability, compared with the non-TSP scenario under the different traffic flow conditions in the morning peak hour. The evaluation results indicate the promising performance of the proposed optimization framework in reducing the passenger delay and improving the bus schedule adherence for the urban transit system.

  1. Application of C/C composites to the combustion chamber of rocket engines. Part 1: Heating tests of C/C composites with high temperature combustion gases

    Science.gov (United States)

    Tadano, Makoto; Sato, Masahiro; Kuroda, Yukio; Kusaka, Kazuo; Ueda, Shuichi; Suemitsu, Takeshi; Hasegawa, Satoshi; Kude, Yukinori

    1995-04-01

    Carbon fiber reinforced carbon composite (C/C composite) has various superior properties, such as high specific strength, specific modulus, and fracture strength at high temperatures of more than 1800 K. Therefore, C/C composite is expected to be useful for many structural applications, such as combustion chambers of rocket engines and nose-cones of space-planes, but C/C composite lacks oxidation resistivity in high temperature environments. To meet the lifespan requirement for thermal barrier coatings, a ceramic coating has been employed in the hot-gas side wall. However, the main drawback to the use of C/C composite is the tendency for delamination to occur between the coating layer on the hot-gas side and the base materials on the cooling side during repeated thermal heating loads. To improve the thermal properties of the thermal barrier coating, five different types of 30-mm diameter C/C composite specimens constructed with functionally gradient materials (FGM's) and a modified matrix coating layer were fabricated. In this test, these specimens were exposed to the combustion gases of the rocket engine using nitrogen tetroxide (NTO) / monomethyl hydrazine (MMH) to evaluate the properties of thermal and erosive resistance on the thermal barrier coating after the heating test. It was observed that modified matrix and coating with FGM's are effective in improving the thermal properties of C/C composite.

  2. Stop feeling: inhibition of emotional interference following stop-signal trials.

    Science.gov (United States)

    Kalanthroff, Eyal; Cohen, Noga; Henik, Avishai

    2013-01-01

    Although a great deal of literature has been dedicated to the mutual links between emotion and the selective attention component of executive control, there is very little data regarding the links between emotion and the inhibitory component of executive control. In the current study we employed an emotional stop-signal task in order to examine whether emotion modulates and is modulated by inhibitory control. Results replicated previous findings showing reduced inhibitory control [longer stop-signal reaction time (SSRT)] following negative, compared to neutral pictures. Most importantly, results show decreased emotional interference following stop-signal trials. These results show that the inhibitory control component of executive control can serve to decrease emotional effects. We suggest that inhibitory control and emotion have a two-way connection in which emotion disrupts inhibitory control and activation of inhibitory control disrupts emotion.

  3. Stop feeling: Inhibition of emotional interference following stop-signal trials

    Directory of Open Access Journals (Sweden)

    Eyal eKalanthroff

    2013-03-01

    Full Text Available Although a great deal of literature has been dedicated to the mutual links between emotion and the selective attention component of executive control, there is very little data regarding the links between emotion and the inhibitory component of executive control. In the current study we employed an emotional stop-signal task in order to examine whether emotion modulates and is modulated by inhibitory control. Results replicated previous findings showing reduced inhibitory control (longer stop-signal reaction time following negative, compared to neutral pictures. Most importantly, results show decreased emotional interference following stop-signal trials. These results show that the inhibitory control component of executive control can serve to decrease emotional effects. We suggest that inhibitory control and emotion have a two-way connection in which emotion disrupts inhibitory control and activation of inhibitory control disrupts emotion.

  4. Stopping-power ratios for dosimetry

    International Nuclear Information System (INIS)

    Andreo, P.

    1988-01-01

    The determination of the absorbed dose at a specified location in a medium irradiated with an electron or photon beam normally consists of two steps: (1) the determination of the mean absorbed dose to a detector by using a calibration factor or performing an absolute measurement, (2) the determination of the absorbed dose to the medium at the point of interest by calculations based on the knowledge of the absorbed dose to the detector and the different stopping and scattering properties of the medium and the detector material. When the influence of the detector is so small that the electron fluence in the medium is not modified, the ratio of the mass collision stopping power of the two materials accounts for the differences in energy deposition, and provides a conversion factor to relate the absorbed dose in both materials. Today, all national and international dosimetry protocols and codes of practice are based on such procedures, and the user easily can carry out these steps using tabulated data to convert a measured quantity to absorbed dose in the irradiated medium at the location of interest. Effects due to the spatial extension of the detector are taken into account using perturbation correction factors. The Monte Carlo method has become the most common and powerful calculational technique for determining the electron fluence (energy spectra) under different irradiation conditions. Cavity theory is then used to calculate stopping-power ratios. In this chapter, the different steps needed to evaluate s-ratios will be considered, emphasizing the different types of cavity-theory integrals and the Monte Carlo techniques used to derive the necessary electron spectra in the range of energies commonly used in radiation dosimetry, i.e., photon and electron beams with energies up to 50 MeV

  5. End-Stop Exemplar Based Recognition

    DEFF Research Database (Denmark)

    Olsen, Søren I.

    2003-01-01

    An approach to exemplar based recognition of visual shapes is presented. The shape information is described by attributed interest points (keys) detected by an end-stop operator. The attributes describe the statistics of lines and edges local to the interest point, the position of neighboring int...... interest points, and (in the training phase) a list of recognition names. Recognition is made by a simple voting procedure. Preliminary experiments indicate that the recognition is robust to noise, small deformations, background clutter and partial occlusion....

  6. Jojoba could stop the desert creep

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-25

    The Sahara desert is estimated to be expanding at a rate of 5km a year. The Sudanese government is experimenting with jojoba in six different regions as the bush has the potential to stop this ''desert creep''. The plant, a native to Mexico, is long known for its resistance to drought and for the versatile liquid wax that can be extracted from its seeds. It is estimated that one hectare of mature plants could produce 3000 kg of oil, currently selling at $50 per litre, and so earn valuable foreign currency.

  7. Early Stop Criterion from the Bootstrap Ensemble

    DEFF Research Database (Denmark)

    Hansen, Lars Kai; Larsen, Jan; Fog, Torben L.

    1997-01-01

    This paper addresses the problem of generalization error estimation in neural networks. A new early stop criterion based on a Bootstrap estimate of the generalization error is suggested. The estimate does not require the network to be trained to the minimum of the cost function, as required...... by other methods based on asymptotic theory. Moreover, in contrast to methods based on cross-validation which require data left out for testing, and thus biasing the estimate, the Bootstrap technique does not have this disadvantage. The potential of the suggested technique is demonstrated on various time...

  8. Range-energy relations and stopping powers of organic liquids and vapours for alpha particles

    International Nuclear Information System (INIS)

    Akhavan-Rezayat, A.; Palmer, R.B.J.

    1980-01-01

    Experimental range-energy relations are presented for alpha particles in methyl alcohol, propyl alcohol, dichloromethane, chloroform and carbon tetrachloride in both the liquid and vapour phases. Stopping power values for these materials and for oxygen gas over the energy range 1.0-8.0 MeV are also given. From these results stopping powers have been derived for the -CH 2 -group and for -Cl occurring in chemical combination in the liquid and vapour phases. The molecular stopping power in the vapour phase is shown to exceed that in the liquid phase by 2-6% below 2 MeV, reducing to negligible differences at about 5 MeV for the materials directly investigated and for the -Cl atom. No significant phase effect is observed for the -CH 2 -group, but it is noted that the uncertainties in the values of the derived stopping powers are much greater in this case. Comparison of the experimental molecular stopping powers with values calculated from elemental values using the Bragg additivity rule shows agreement for vapours but not for liquids. (author)

  9. Development of an automated vehicle stop system for cardiac emergencies

    Directory of Open Access Journals (Sweden)

    Tung T. Nguyen

    2017-06-01

    Full Text Available This paper describes the concept and configuration of a novel automated safety vehicle stop system, and a future prospect of the study. Intrinsic sudden death may cause traffic accident since such accidents sometimes involve not only the driver but also other traffic users such as passengers and pedestrians. Cardiovascular disease (CVD is considered as a serious driving risk factor. The pain and others effects of cardiac events degrade driver’s performance, and CVD causes ischemia brought by the CVD induces incapacity of driving. In the automated safety vehicle stop system, which our research group has developed, steer-sensors collects bio-signals and a camera captures the driver’s posture to monitor driver’s incapability. When the driver loses his or her driving capability, the system takes over the maneuver of the vehicle and automatically drives to a safety spot by observing the traffic environment. An emergency scenario was used to demonstrate the system verifying its potential.

  10. Frame by frame stop motion non-traditional approaches to stop motion animation

    CERN Document Server

    Gasek, Tom

    2011-01-01

    In a world that is dominated by computer images, alternative stop motion techniques like pixilation, time-lapse photography and down-shooting techniques combined with new technologies offer a new, tangible and exciting approach to animation. With over 25 years professional experience, industry veteran, Tom Gasek presents a comprehensive guide to stop motion animation without the focus on puppetry or model animation. With tips, tricks and hands-on exercises, Frame by Frame will help both experienced and novice filmmakers get the most effective results from this underutilized branch of animation

  11. A search for bar νe appearance from stopped π+ and μ+ decay at LAMPF

    International Nuclear Information System (INIS)

    Fujikawa, B.K.

    1990-01-01

    The author reports on a recent search for bar ν e appearance from stopped π + → μ + ν μ and μ + → e + ν e bar ν μ decay made by the LAMPF experiment E645. The appearance of bar ν e may occur from bar ν μ → bar ν e , ν e → bar ν eL , or ν μ → bar ν eL oscillations. Appearance may also occur from rare μ + → e + bar ν e ν μ decay, which is allowed by a multiplicative lepton charge conservation law. The neutrino energies range from E ν = 0 to 52.8MeV. The neutrino detector, which is located 26.1 meters from the neutrino source, consists of a segmented liquid scintillator and proportional drift tube central detector surrounded by both active and passive shielding. The central detector detects bar ν e through the bar ν e p → ne + Charge Current (CC) reaction, which is signaled by the direct detection of the final state positron and neutron. The hydrogen-rich liquid scintillators act as free proton targets for the bar ν e p CC reaction. The neutrons are detected through radiative neutron capture on gadolinium. He finds no evidence for bar ν e appearance in the first year of running. New limits on the bar ν μ , ν e , ν μ yields bar ν e oscillation parameters and the rare μ + → e + bar ν e ν μ decay branching ratio are presented

  12. Effect of salt stress on the physiology of Frankia sp strain CcI6

    Indian Academy of Sciences (India)

    2013-10-01

    Oct 1, 2013 ... the strain is closely related to Frankia sp. strain CcI3. ... [Oshone R, Mansour SR and Tisa LS 2013 Effect of salt stress on the physiology of Frankia sp strain CcI6. .... This work was supported in part by US-Egypt Joint Research.

  13. A bonding study of c-C5H8 adsorption on Pt(111)

    International Nuclear Information System (INIS)

    Simonetti, S.; Jasen, P.; Gonzalez, E.; Juan, A.; Brizuela, G.

    2006-01-01

    The chemisorption of cyclopentane (c-C 5 H 8 ) on Pt(111) has been studied using a qualitative band-structure calculations in the framework of tight-binding implementation with the YAeHMOP package. We modeled the metal surface by a two-dimensional slab of finite thickness with an overlayer of c-C 5 H 8 , in a (3x3) di-σ geometry. The c-C 5 H 8 molecule is attached to the surface with its C?C atoms bonded mainly with two Pt atoms while the opposite CH 2 bends towards the surface. The Pt?Pt bonds in the underlying surface and the C?C bonds of c-C 5 H 8 are weakened upon the chemisorption. A noticeable Pt-H and Pt-C interactions has been observed. We found that of Pt 5d z 2 band plays an important role in the bonding between c-C 5 H 8 and the surface, as do the Pt 6s and 6p z bands. The HOMO-LUMO bands of c-C 5 H 8 are very dispersed, indicative of a strong interaction with the metal surface

  14. Interaction between two stopped light pulses

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yi-Hsin, E-mail: yhchen920@gmail.com; Lee, Meng-Jung, E-mail: yhchen920@gmail.com; Hung, Weilun, E-mail: yhchen920@gmail.com; Yu, Ite A., E-mail: yu@phys.nthu.edu.tw [Department of Physics and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Chen, Ying-Cheng [Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan and Department of Physics and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Chen, Yong-Fan [Department of Physics, National Cheng Kung University, Tainan 70101, Taiwan (China)

    2014-03-05

    The efficiency of a nonlinear optical process is proportional to the interaction time. We report a scheme of all-optical switching based on two motionless light pulses via the effect of electromagnetically induced transparency. One pulse was stopped as the stationary light pulse (SLP) and the other was stopped as stored light. The time of their interaction via the medium can be prolonged and, hence, the optical nonlinearity is greatly enhanced. Using a large optical density (OD) of 190, we achieved a very long interaction time of 6.9 μs. This can be analogous to the scheme of trapping light pulses by an optical cavity with a Q factor of 8×10{sup 9}. With the approach of using moving light pulses in the best situation, a switch can only be activated at 2 photons per atomic absorption cross section. With the approach of employing a SLP and a stored light pulse, a switch at only 0.56 photons was achieved and the efficiency is significantly improved. Moreover, the simulation results are in good agreement with the experimental data and show that the efficiency can be further improved by increasing the OD of the medium. Our work advances the technology in quantum information manipulation utilizing photons.

  15. Seismic stops vs. snubbers, a reliable alternative

    International Nuclear Information System (INIS)

    Cloud, R.L.; Anderson, P.H.; Leung, J.S.M.

    1988-01-01

    The Seismic Stops methodology has been developed to provide a reliable alternative for providing seismic support to nuclear power plant piping. The concept is based on using rigid passive supports with large clearances. These gaps permit unrestrained thermal expansion while limiting excessive seismic displacements. This type of restraint has performed successfully in fossil fueled power plants. A simplified production analysis tool has been developed which evaluates the nonlinear piping response including the effect of the gapped supports. The methodology utilizes the response spectrum approach and has been incorporated into a piping analysis computer program RLCA-GAP. Full scale shake table tests of piping specimens were performed to provide test correlation with the developed methodology. Analyses using RLCA-GAP were in good agreement with test results. A sample piping system was evaluated using the Seismic Stops methodology to replace the existing snubbers with passive gapped supports. To provide further correlation data, the sample system was also evaluated using nonlinear time history analysis. The correlation comparisons showed RLCA-GAP to be a viable methodology and a reliable alternative for snubber optimization and elimination. (orig.)

  16. Contrast effects on stop consonant identification.

    Science.gov (United States)

    Diehl, R L; Elman, J L; McCusker, S B

    1978-11-01

    Changes in the identification of speech sounds following selective adaptation are usually attributed to a reduction in sensitivity of auditory feature detectors. An alternative explanation of these effects is based on the notion of response contrast. In several experiments, subjects identified the initial segment of synthetic consonant-vowel syllables as either the voiced stop [b] or the voiceless stop [ph]. Each test syllable had a value of voice onset time (VOT) that placed it near the English voiced-voiceless boundary. When the test syllables were preceded by a single clear [b] (VOT = -100 msec), subjects tended to identify them as [ph], whereas when they were preceded by an unambiguous [ph] (VOT = 100 msec), the syllables were predominantly labeled [b]. This contrast effect occurred even when the contextual stimuli were velar and the test stimuli were bilabial, which suggests a featural rather than a phonemic basis for the effect. To discount the possibility that these might be instances of single-trial sensory adaptation, we conducted a similar experiment in which the contextual stimuli followed the test items. Reliable contrast effects were still obtained. In view of these results, it appears likely that response contrast accounts for at least some component of the adaptation effects reported in the literature.

  17. Interaction between two stopped light pulses

    International Nuclear Information System (INIS)

    Chen, Yi-Hsin; Lee, Meng-Jung; Hung, Weilun; Yu, Ite A.; Chen, Ying-Cheng; Chen, Yong-Fan

    2014-01-01

    The efficiency of a nonlinear optical process is proportional to the interaction time. We report a scheme of all-optical switching based on two motionless light pulses via the effect of electromagnetically induced transparency. One pulse was stopped as the stationary light pulse (SLP) and the other was stopped as stored light. The time of their interaction via the medium can be prolonged and, hence, the optical nonlinearity is greatly enhanced. Using a large optical density (OD) of 190, we achieved a very long interaction time of 6.9 μs. This can be analogous to the scheme of trapping light pulses by an optical cavity with a Q factor of 8×10 9 . With the approach of using moving light pulses in the best situation, a switch can only be activated at 2 photons per atomic absorption cross section. With the approach of employing a SLP and a stored light pulse, a switch at only 0.56 photons was achieved and the efficiency is significantly improved. Moreover, the simulation results are in good agreement with the experimental data and show that the efficiency can be further improved by increasing the OD of the medium. Our work advances the technology in quantum information manipulation utilizing photons

  18. Polarizable Embedded RI-CC2 Method for Two-Photon Absorption Calculations

    DEFF Research Database (Denmark)

    Hršak, Dalibor; Khah, Alireza Marefat; Christiansen, Ove

    2015-01-01

    We present a novel polarizable embedded resolution-of-identity coupled cluster singles and approximate doubles (PERI-CC2) method for calculation of two-photon absorption (TPA) spectra of large molecular systems. The method was benchmarked for three types of systems: a water-solvated molecule...... of formamide, a uracil molecule in aqueous solution, and a set of mutants of the channelrhodopsin (ChR) protein. The first test case shows that the PERI-CC2 method is in excellent agreement with the PE-CC2 method and in good agreement with the PE-CCSD method. The uracil test case indicates that the effects...... of hydrogen bonding on the TPA of a chromophore with the nearest environment is well-described with the PERI-CC2 method. Finally, the ChR calculation shows that the PERI-CC2 method is well-suited and efficient for calculations on proteins with medium-sized chromophores....

  19. Energy Materials Coordinating Committee (EMaCC): Fiscal year 1996. Annual technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department`s materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. The EMaCC reports to the Director of the Office of Energy Research in his or her capacity as overseer of the technical programs of the Department. This annual technical report is mandated by the EMaCC terms of reference. This report summarizes EMaCC activities for FY 1996 and describes the materials research programs of various offices and divisions within the Department.

  20. Energy Materials Coordinating Committee (EMaCC): Fiscal year 1996. Annual technical report

    International Nuclear Information System (INIS)

    1997-08-01

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. The EMaCC reports to the Director of the Office of Energy Research in his or her capacity as overseer of the technical programs of the Department. This annual technical report is mandated by the EMaCC terms of reference. This report summarizes EMaCC activities for FY 1996 and describes the materials research programs of various offices and divisions within the Department

  1. Effects of differently hardened brass foil laminate on the electromechanical property of externally laminated CC tapes

    Energy Technology Data Exchange (ETDEWEB)

    Bautista, Zhierwinjay; Shin, Hyung Seop [Dept. of Mechanical Design Engineering, Andong National University, Andong (Korea, Republic of); Mean, Byoung Jean; Lee, Jae Hun [SuNAM Co Ltd., Anseong (Korea, Republic of)

    2016-12-15

    The mechanical properties of REBCO coated conductor (CC) wires under uniaxial tension are largely determined by the thick component layers in the architecture, namely, the substrate and the stabilizer or even the reinforcement layer. Depending on device applications of the CC tapes, it is necessary to reinforce thin metallic foils externally to one-side or both sides of the CC tapes. Due to the external reinforcement of brass foils, it was found that this could increase the reversible strain limit from the Cu-stabilized CC tapes. In this study, the effects of differently hardened brass foil laminate on the electromechanical property of CC tapes were investigated under uniaxial tension loading. The tensile strain dependence of the critical current (I{sub c}) was measured at 77 K and self-field. Depending on whether the I{sub c} of CC tapes were measured during loading or after unloading, a reversible strain (or stress) limit could be determined, respectively. The both-sides of the Cu-stabilized CC tapes were laminated with brass foils with different hardness, namely 1/4H, 1H and EH. From the obtained results, it showed that the yield strength of the brass laminated CC tapes with EH brass foil laminate was comparable to the one of the Cu-stabilized CC tape due to its large yield strength even though its large volume fraction. It was found that the brass foil with different hardness was mainly sensitive on the stress dependence of I{sub c}, but not on the strain sensitivity due to the residual strain induced in the laminated CC tapes during unloading.

  2. Who stops selling? A systematic analysis of ex-tobacco retailers.

    Science.gov (United States)

    Feletto, Eleonora; Burton, Suzan; Williams, Kelly; Fry, Rae; Sutton, Clare; Bagus, Lachlan; Egger, Sam

    2016-03-09

    There is evidence that wide distribution of cigarettes contributes to smoking, and multiple commentators have called for a review of tobacco retailing. This study analyses retailers who stop selling cigarettes, why they do so, and discusses the implications for tobacco control. An audit of tobacco retailers in the Australian state of NSW was used to identify retailers who had stopped selling tobacco, and they were then compared with current retailers to determine how many, and what types of outlets stop selling tobacco. Attempts were made to contact and interview all former tobacco retailers identified in three audited regions. In-depth interviews were conducted with 13 ex-tobacco retailers, or 31% of the subset of ex-tobacco retailers. Low-volume outlet types were over-represented as a proportion of retailers exiting the market, and some had resumed selling within 18 months of the audit. Low profits were often cited as a contributor to stopping; however, in all but one case, the decision to stop selling was also influenced by a significant change in business circumstances-either legislative or other business changes. Few retailers stop selling tobacco while continuing in the same business, and those who stop disproportionately represent retailer types with low sales volume. The results suggest that legislative changes provide a window where retailers could be prompted to exit the market. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  3. Metal-organic cooperative catalysis in C-H and C-C bond activation and its concurrent recovery.

    Science.gov (United States)

    Park, Young Jun; Park, Jung-Woo; Jun, Chul-Ho

    2008-02-01

    The development of an efficient catalytic activation (cleavage) system for C-H and C-C bonds is an important challenge in organic synthesis, because these bonds comprise a variety of organic molecules such as natural products, petroleum oils, and polymers on the earth. Among many elegant approaches utilizing transition metals to activate C-H and C-C bonds facilely, chelation-assisted protocols based on the coordinating ability of an organic moiety have attracted great attention, though they have often suffered from the need for an intact coordinating group in a substrate. In this Account, we describe our entire efforts to activate C-H or C-C bonds adjacent to carbonyl groups by employing a new concept of metal-organic cooperative catalysis (MOCC), which enables the temporal installation of a 2-aminopyridyl group into common aldehydes or ketones in a catalytic way. Consequently, a series of new catalytic reactions such as alcohol hydroacylation, oxo-ester synthesis, C-C triple bond cleavage, hydrative dimerization of alkynes, and skeletal rearrangements of cyclic ketones was realized through MOCC. In particular, in the quest for an optimized MOCC system composed of a Wilkinson's catalyst (Ph 3P) 3RhCl and an organic catalyst (2-amino-3-picoline), surprising efficiency enhancements could be achieved when benzoic acid and aniline were introduced as promoters for the aldimine formation process. Furthermore, a notable accomplishment of C-C bond activation has been made using 2-amino-3-picoline as a temporary chelating auxiliary in the reactions of unstrained ketones with various terminal olefins and Wilkinson's catalyst. In the case of seven-membered cyclic ketones, an interesting ring contraction to five- or six-membered ones takes place through skeletal rearrangements initiated by the C-C bond activation of MOCC. On the other hand, the fundamental advances of these catalytic systems into recyclable processes could be achieved by immobilizing both metal and organic

  4. The methylenetetrahydrofolate reductase c.c.677 C>T and c.c.1298 A>C polymorphisms in reproductive failures: Experience from an RSA and RIF study on a Polish population.

    Science.gov (United States)

    Nowak, Izabela; Bylińska, Aleksandra; Wilczyńska, Karolina; Wiśniewski, Andrzej; Malinowski, Andrzej; Wilczyński, Jacek R; Radwan, Paweł; Radwan, Michał; Barcz, Ewa; Płoski, Rafał; Motak-Pochrzęst, Hanna; Banasik, Małgorzata; Sobczyński, Maciej; Kuśnierczyk, Piotr

    2017-01-01

    Almost 1600 individuals from the Polish population were recruited to this study. Among them 319 were fertile couples, 289 were recurrent spontaneous abortion (RSA) couples, and 131 were in the group of recurrent implantation failure (RIF) following in vitro fertilization. The aim of this study was to evaluate the MTHFR c.c.677 C>T and c.c.1298 A>C polymorphisms' association with RSA and RIF. We used PCR-RFLP with HinfI (677 C>T) and MboII (1298 A>C) digestion. We observed a protective effect of the female AC genotype (OR = 0.64, p = 0.01) and the C allele (AC+CC genotypes; OR = 0.65, p = 0.009) against RSA. Moreover, 1298 AA/677 CT women were more frequent in RSA (31.14%) and RIF (25.20%) groups in comparison to fertile women (22.88%), although this difference was significant only in the case of RSA (p = 0.022, OR = 1.52). Male combined genotype analysis revealed no association with reproductive failure of their partners. Nevertheless, the female/male combination AA/AC of the 1298 polymorphism was more frequent in RSA couples (p = 0.049, OR = 1.49). However, the significant results became insignificant after Bonferroni correction. In addition, analysis of haplotypes showed significantly higher frequency of the C/C haplotype (1298 C/677 C) in the female control group than in the female RSA group (p = 0.03, OR = 0.77). Moreover, the association between elevated homocysteine (Hcy) level in plasma of RSA and RIF women and MTHFR polymorphisms was investigated but did not reveal significant differences. In conclusion, for clinical practice, it is better to check the homocysteine level in plasma and, if the Hcy level is increased, to recommend patients to take folic acid supplements rather than undergo screening of MTHFR for 1298 A>C and 677 C>T polymorphisms.

  5. Stopping power for heavy ions in low energy region

    International Nuclear Information System (INIS)

    Kitagawa, Mitsuo

    1983-01-01

    Review is made for the study on the power for stopping heavy ions. The studies on the power for stopping heavy ions passing through materials have been developed in the last twenty years due to the accuracy improvement in the data analysis of the power for stopping light ions, the requirement of data establishment on the power for stopping heavy ions from fusion research and the development of the experimental studies by heavy-ion accelerators. The relation between the analysis of the power for stopping heavy ions and the power for stopping light ions is described from the standpoint that the results on the power for stopping light ions serve as the guide for the study on the power for stopping heavy ions. Both at present and in future. The analysis of stopping power data with the accuracy from +-10 to 20 % is possible from the theoretical analysis of effective electric charge and its systematic table of the numerical data. The outline of the scaling rule on effective electric charge is discussed. The deviation of the experimental data from the scaling rule is discussed by comparing with the measured values of effective electric charge ratio. Various analyses of the power for stopping heavy ions are summarized. (Asami, T.)

  6. Intelligent Bus Stops in the Flexible Bus Systems

    Directory of Open Access Journals (Sweden)

    Razi Iqbal

    2014-09-01

    Full Text Available The purpose of this paper is to discuss Intelligent Bus Stops in a special Demand Responsive Transit (DRT, the Flexible Bus System. These Intelligent Bus Stops are more efficient and information rich than Traditional Bus Stops. The real time synchronization of the Flexible Bus System makes it unique as compared to Traditional Bus Systems. The Main concern is to make Bus Stops intelligent and information rich. Buses are informed about the no. of passengers waiting at the upcoming Bus Stops. If there are no passengers to ride or get off on upcoming Bus Stop, the Bus can skip that Bus Stop and head towards the next Bus Stop where passenger is waiting, which will decrease the ride time of the passengers on the Bus and also the wait time of the passengers waiting on the upcoming Bus Stops. Providing more information at Bus Stops about the Destination (Time to Destination, Distance to Destination etc. and Buses (Bus Location, Arrival Time of Bus etc. makes it easier for the passengers to decide whether to ride a particular Bus or not.

  7. Extreme control of light in metamaterials: Complete and loss-free stopping of light

    International Nuclear Information System (INIS)

    Tsakmakidis, Kosmas L.; Hess, Ortwin

    2012-01-01

    We present an overview of recent advances within the field of slow- and stopped-light in metamaterial and plasmonic waveguides. We start by elucidating the mechanisms by which these configurations can enable complete stopping of light. Decoherence mechanisms may destroy the zero-group-velocity condition for real-frequency/complex-wavevector modes, but we show that metamaterial and nanoplasmonic waveguides also support complex-frequency/real-wavevector modes that uphold the light-stopping condition. A further point of focus is how, by using gain, dissipative losses can be overcome in the slow- and stopped-light regimes. To this end, on the basis of full-wave finite-difference time-domain (FDTD) simulations and analytic transfer-matrix calculations, we show that the incorporation of thin layers made of an active medium, placed adjacently to the core layer of a negative-refractive-index waveguide, can fully remove dissipative losses - in a slow- or stopped-light regime where the effective index of the guided lightwave remains negative.

  8. The MSSM without gluinos; an effective field theory for the stop sector

    Energy Technology Data Exchange (ETDEWEB)

    Aebischer, Jason; Greub, Christoph [University of Bern, Albert Einstein Center for Fundamental Physics, Institute for Theoretical Physics, Bern (Switzerland); Crivellin, Andreas [Paul Scherrer Institut (PSI), Villigen (Switzerland); Yamada, Youichi [Tohoku University, Department of Physics, Sendai (Japan)

    2017-11-15

    In this article we study the MSSM with stops and Higgs scalars much lighter than gluinos and squarks of the first two generations. In this setup, one should use an effective field theory with partial supersymmetry in which the gluino and heavy squarks are integrated out in order to connect SUSY parameters (given at a high scale) to observables in the stop sector. In the construction of this effective theory, valid below the gluino mass scale, we take into account O(α{sub 3}) and O(Y{sub t,b}{sup 2}) effects and calculate the matching as well as the renormalization group evolution. As a result, the running of the parameters for the stop sector is modified with respect to the full MSSM and SUSY relations between parameters are broken. We show that for some couplings sizable numerical differences exist between the effective field theory approach and the naive calculation based on the MSSM running. (orig.)

  9. Remune trial will stop; new trials planned.

    Science.gov (United States)

    James, J S

    1999-05-21

    A clinical trial using remune, the anti-HIV vaccine developed by the late Dr. Jonas Salk, has been ended. The study is a clinical-endpoint trial which looks for statistically significant differences in AIDS sickness or death between patients who add remune to their treatment regimens versus those who use a placebo. Agouron Pharmaceuticals and the Immune Response Corporation who were conducting the trial announced their decision to stop it after an analysis by the Data Safety Monitoring Board. No differences in clinical endpoints were found and it was projected that continuing the trial would likely not find any. The companies are now planning two new Phase III trials using viral load testing rather than clinical endpoints as study criteria.

  10. Stop Lepton Associated Production at Hadron Colliders

    CERN Document Server

    Alves, A; Plehn, Tilman

    2003-01-01

    At hadron colliders, the search for R-parity violating supersymmetry can probe scalar masses beyond what is covered by pair production processes. We evaluate the next-to-leading order SUSY-QCD corrections to the associated stop or sbottom production with a lepton through R-parity violating interactions. We show that higher order corrections render the theoretical predictions more stable with respect to variations of the renormalization and factorization scales and that the total cross section is enhanced by a factor up to 70% at the Tevatron and 50% at the LHC. We investigate in detail how the heavy supersymmetric states decouple from the next-to-leading order process, which gives rise to a theory with an additional scalar leptoquark. In this scenario the inclusion of higher order QCD corrections increases the Tevatron reach on leptoquark masses by up to 40 GeV and the LHC reach by up to 200 GeV.

  11. The Novel Microwave Stop-Band Filter

    Directory of Open Access Journals (Sweden)

    R. E. Chernobrovkin

    2008-01-01

    Full Text Available The stop-band filter with the new band-rejection element is proposed. The element is a coaxial waveguide with the slot in the centre conductor. In the frame of this research, the numerical and experimental investigations of the amplitude-frequency characteristics of the filter are carried out. It is noted that according to the slot parameters the two typical resonances (half-wave and quarter-wave can be excited. The rejection band of the single element is defined by the width, depth, and dielectric filling of the slot. Fifth-order Chebyshev filter utilizing the aforementioned element is also synthesized, manufactured, and tested. The measured and simulated results are in good agreement. The experimental filter prototype exhibits the rejection band 0.86 GHz at the level −40 dB.

  12. 10 blows that stopped nuclear power

    International Nuclear Information System (INIS)

    Komanoff, C.

    1991-01-01

    The author describes these 10 blows in chronological order, 1973 through 1981, namely: (1) Arab Oil Embargo; (2) India Explodes a Bomb; (3) NRC replaces AEC; (4) Fire at Browns Ferry; (5) General Electric and NRC Engineers switch Sides; (6) Amory Lovins Recasts the Energy Debate; (7) The Seabrook Occupation; (8) The Three Mile Island Accident; (9) Federal Reserve Tightens the Money Supply; and (1) Pacific Gas and Electric Co. Gets it Backwards at Diablo Canyon. he stops there, not including the Washington Public Power Supply fiasco and the Chernobyl disaster, feeling nuclear expansion was essentially foreclosed without them. Further, he feels nuclear power seems fated to be forever at the mercy of forces beyond its control

  13. Durability Indicators Comparison for SCC and CC in Tropical Coastal Environments.

    Science.gov (United States)

    Calado, Carlos; Camões, Aires; Monteiro, Eliana; Helene, Paulo; Barkokébas, Béda

    2015-03-27

    Self-compacting concrete (SCC) demands more studies of durability at higher temperatures when subjected to more aggressive environments in comparison to the conventional vibrated concrete (CC). This work aims at presenting results of durability indicators of SCC and CC, having the same water/binder relations and constituents. The applied methodologies were electrical resistivity, diffusion of chloride ions and accelerated carbonation experiments, among others, such as microstructure study, scanning electron microscope and microtomography experiments. The tests were performed in a research laboratory and at a construction site of the Pernambuco Arena. The obtained results shows that the SCC presents an average electrical resistivity 11.4% higher than CC; the average chloride ions diffusion was 63.3% of the CC; the average accelerated carbonation penetration was 45.8% of the CC; and the average open porosity was 55.6% of the CC. As the results demonstrated, the SCC can be more durable than CC, which contributes to elucidate the aspects related to its durability and consequent prolonged life cycle.

  14. Durability Indicators Comparison for SCC and CC in Tropical Coastal Environments

    Directory of Open Access Journals (Sweden)

    Carlos Calado

    2015-03-01

    Full Text Available Self-compacting concrete (SCC demands more studies of durability at higher temperatures when subjected to more aggressive environments in comparison to the conventional vibrated concrete (CC. This work aims at presenting results of durability indicators of SCC and CC, having the same water/binder relations and constituents. The applied methodologies were electrical resistivity, diffusion of chloride ions and accelerated carbonation experiments, among others, such as microstructure study, scanning electron microscope and microtomography experiments. The tests were performed in a research laboratory and at a construction site of the Pernambuco Arena. The obtained results shows that the SCC presents an average electrical resistivity 11.4% higher than CC; the average chloride ions diffusion was 63.3% of the CC; the average accelerated carbonation penetration was 45.8% of the CC; and the average open porosity was 55.6% of the CC. As the results demonstrated, the SCC can be more durable than CC, which contributes to elucidate the aspects related to its durability and consequent prolonged life cycle.

  15. RB1CC1 Protein Suppresses Type II Collagen Synthesis in Chondrocytes and Causes Dwarfism*

    Science.gov (United States)

    Nishimura, Ichiro; Chano, Tokuhiro; Kita, Hiroko; Matsusue, Yoshitaka; Okabe, Hidetoshi

    2011-01-01

    RB1-inducible coiled-coil 1 (RB1CC1) functions in various processes, such as cell growth, differentiation, senescence, apoptosis, and autophagy. The conditional transgenic mice with cartilage-specific RB1CC1 excess that were used in the present study were made for the first time by the Cre-loxP system. Cartilage-specific RB1CC1 excess caused dwarfism in mice without causing obvious abnormalities in endochondral ossification and subsequent skeletal development from embryo to adult. In vitro and in vivo analysis revealed that the dwarf phenotype in cartilaginous RB1CC1 excess was induced by reductions in the total amount of cartilage and the number of cartilaginous cells, following suppressions of type II collagen synthesis and Erk1/2 signals. In addition, we have demonstrated that two kinds of SNPs (T-547C and C-468T) in the human RB1CC1 promoter have significant influence on the self-transcriptional level. Accordingly, human genotypic variants of RB1CC1 that either stimulate or inhibit RB1CC1 transcription in vivo may cause body size variations. PMID:22049074

  16. Pharmacokinetics and Pharmacodynamics with Extended Dosing of CC-486 in Patients with Hematologic Malignancies.

    Directory of Open Access Journals (Sweden)

    Eric Laille

    Full Text Available CC-486 (oral azacitidine is an epigenetic modifier in development for patients with myelodysplastic syndromes and acute myeloid leukemia. In part 1 of this two-part study, a 7-day CC-486 dosing schedule showed clinical activity, was generally well tolerated, and reduced DNA methylation. Extending dosing of CC-486 beyond 7 days would increase duration of azacitidine exposure. We hypothesized that extended dosing would therefore provide more sustained epigenetic activity. Reported here are the pharmacokinetic (PK and pharmacodynamic (PD profiles of CC-486 extended dosing schedules in patients with myelodysplastic syndromes (MDS, chronic myelomonocytic leukemia (CMML or acute myeloid leukemia (AML from part 2 of this study. PK and/or PD data were available for 59 patients who were sequentially assigned to 1 of 4 extended CC-486 dosing schedules: 300mg once-daily or 200mg twice-daily for 14 or 21 days per 28-day cycle. Both 300mg once-daily schedules and the 200mg twice-daily 21-day schedule significantly (all P < .05 reduced global DNA methylation in whole blood at all measured time points (days 15, 22, and 28 of the treatment cycle, with sustained hypomethylation at cycle end compared with baseline. CC-486 exposures and reduced DNA methylation were significantly correlated. Patients who had a hematologic response had significantly greater methylation reductions than non-responding patients. These data demonstrate that extended dosing of CC-486 sustains epigenetic effects through the treatment cycle.ClinicalTrials.gov NCT00528983.

  17. Cu-catalyzed esterification reaction via aerobic oxygenation and C-C bond cleavage: an approach to α-ketoesters.

    Science.gov (United States)

    Zhang, Chun; Feng, Peng; Jiao, Ning

    2013-10-09

    The Cu-catalyzed novel aerobic oxidative esterification reaction of 1,3-diones for the synthesis of α-ketoesters has been developed. This method combines C-C σ-bond cleavage, dioxygen activation and oxidative C-H bond functionalization, as well as provides a practical, neutral, and mild synthetic approach to α-ketoesters which are important units in many biologically active compounds and useful precursors in a variety of functional group transformations. A plausible radical process is proposed on the basis of mechanistic studies.

  18. Age-related variability of some characters of karyotype instability in the mouse line CC57W/Mv

    International Nuclear Information System (INIS)

    Glazko, T.T.; Safonova, N.A.; Kovaleva, O.A.; Stolina, M.P.; Solomko, A.P.; Malyuta, S.S.; Glazko, V.I.; AN Ukrainskoj SSR, Kiev

    1995-01-01

    The investigations of relations between cytogenetical variability in cells of bone marrow of the mouse line CC57W/Mv and factors of age and radioactivity pollution (the specific vivarium in the 30-km Chernobyl zone) were carried out. The karyotype instability on some characters were similarly between young mice in the Chernobyl zone and old mice under control conditions. The old Chernobyl mice differentiated from old control ones by a low frequency of some cytogenetic anomalies and higher values of the mitotic index. The contribution of the intensity of cell division into observed variabilities of cytogenetic character between different mouse groups was discussed

  19. Stop Codon Reassignment in the Wild

    Energy Technology Data Exchange (ETDEWEB)

    Ivanova, Natalia [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Schwientek, Patrick [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Tripp, H. James [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Rinke, Christian [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Pati, Amrita [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Huntemann, Marcel [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Visel, Axel [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Woyke, Tanja [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Kyrpides, Nikos [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.; Rubin, Edward [Lawrence Berkeley National Lab. (LBNL), Walnut Creek, CA (United States). Dept. of Energy Joint Genome Inst.

    2014-03-21

    Since the discovery of the genetic code and protein translation mechanisms (1), a limited number of variations of the standard assignment between unique base triplets (codons) and their encoded amino acids and translational stop signals have been found in bacteria and phages (2-3). Given the apparent ubiquity of the canonical genetic code, the design of genomically recoded organisms with non-canonical codes has been suggested as a means to prevent horizontal gene transfer between laboratory and environmental organisms (4). It is also predicted that genomically recoded organisms are immune to infection by viruses, under the assumption that phages and their hosts must share a common genetic code (5). This paradigm is supported by the observation of increased resistance of genomically recoded bacteria to phages with a canonical code (4). Despite these assumptions and accompanying lines of evidence, it remains unclear whether differential and non-canonical codon usage represents an absolute barrier to phage infection and genetic exchange between organisms. Our knowledge of the diversity of genetic codes and their use by viruses and their hosts is primarily derived from the analysis of cultivated organisms. Advances in single-cell sequencing and metagenome assembly technologies have enabled the reconstruction of genomes of uncultivated bacterial and archaeal lineages (6). These initial findings suggest that large scale systematic studies of uncultivated microorganisms and viruses may reveal the extent and modes of divergence from the canonical genetic code operating in nature. To explore alternative genetic codes, we carried out a systematic analysis of stop codon reassignments from the canonical TAG amber, TGA opal, and TAA ochre codons in assembled metagenomes from environmental and host-associated samples, single-cell genomes of uncultivated bacteria and archaea, and a collection of phage sequences

  20. Identification and expression analysis of a CC chemokine from cobia (Rachycentron canadum).

    Science.gov (United States)

    Feng, Juan; Su, Youlu; Guo, Zhixun; Xu, Liwen; Sun, Xiuxiu; Wang, Yunxin

    2013-06-01

    Chemokines are small, secreted cytokine peptides known principally for their ability to induce migration and activation of leukocyte populations and regulate the immune response mechanisms. The cobia (Rachycentron canadum), a marine finfish species, has a great potential for net cage aquaculture in the South China Sea. We isolated and characterized a CC chemokine cDNA from cobia-designated RcCC2. Its cDNA is 783 bp in length and encodes a putative protein of 110 amino acids. Homology and phylogenetic analysis revealed that the RcCC2 gene, which contains four conserved cysteine residues, shares a high degree of similarity with other known CC chemokine sequences and is closest to the CCL19/21 clade. The mRNA of RcCC2 is expressed constitutively in all tested tissues, including gill, liver, muscle, spleen, kidney, head kidney, skin, brain, stomach, intestine and heart, but not blood, with the highest level of expression in gill and liver. The reverse transcription quantitative polymerase chain reaction was used to examine the expression of the RcCC2 gene in immune-related tissues, including head kidney, spleen and liver, following intraperitoneal injection of the viral mimic polyriboinosinic polyribocytidylic acid, formalin-killed Vibrio carchariae (bacterial vaccine) and phosphate-buffered saline as a control. RcCC2 gene expression was up-regulated differentially in head kidney, spleen and liver during 12 h after challenge. These results indicate that the RcCC2 gene is inducible and is involved in immune responses, suggesting RcCC2 has an important role in the early stage of viral and bacterial infections.

  1. 20 CFR 662.430 - Under what conditions may One-Stop operators designated to operate in a One-Stop delivery system...

    Science.gov (United States)

    2010-04-01

    ... designated to operate in a One-Stop delivery system established prior to the enactment of WIA be designated... DESCRIPTION OF THE ONE-STOP SYSTEM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT One-Stop Operators § 662.430 Under what conditions may One-Stop operators designated to operate in a One-Stop delivery system...

  2. Design of permanent block stopping to resist strata convergence

    Energy Technology Data Exchange (ETDEWEB)

    Ray, R.E.

    1985-11-01

    Conventional concrete block plastered with a cementitious coating is the most common material used in the construction of permanent stoppings to direct airflow in underground mines in the US. All mines experience various degrees of strata convergence depending on depth of overburden, geological conditions, and type of roof support employed. Strata convergence will cause cracks and joint openings in masonry stoppings, resulting in significant air leakage losses. Where strata convergence is severe, complete structural failure of the stopping can ultimately occur. Reconstruction of damaged or destroyed stoppings adds expensive overheads to mining operations, and even greater expenses are incurred from the additional fan horsepower required to overcome leakage losses. Ideally, a stopping should maintain high resistance to airflow while yielding to strata convergence. By properly incorporating a polyisocyanurate rigid foam material within the masonry block structure, stopping service life can be increased in mines experiencing strata convergence problems such as floor heave, roof loading, and lateral rib movement.

  3. Energy Materials Coordinating Committee (EMaCC) Fiscal Year 1999 annual technical report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2000-10-31

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department`s materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. This report summarizes EMaCC activities for FY 1999 and describes the materials research programs of various offices and divisions within the Department.

  4. Energy Materials Coordinating Committee (EMaCC): Annual technical report, Fiscal year 1987

    International Nuclear Information System (INIS)

    1988-09-01

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further the effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. This annual technical report is mandated by the EMaCC terms of reference. This report summarizes EMaCC activities for FY 1987 and describes the materials research programs of various offices and divisions within the Department

  5. Development of high conductive C/C composite tiles for plasma facing armor

    International Nuclear Information System (INIS)

    Ioki, K.; Namiki, K.; Tsujimura, S.; Toyoda, M.; Seki, M.; Takatsu, H.

    1991-01-01

    C/C composites with high thermal conductivity were developed in unidirectional, two-dimensional and felt types, and were fabricated as full-scale armor tile. Their thermal conductivity in the direction perpendicular to the plasma-side surface is 250∝550 W/mdeg C, that is comparable to that of pyrolytic graphite. It was shown by heat load tests that the C/C composites have low surface erosion characteristics and high thermal shock resistance. Various kinds of C/C composites were successfully bonded to metal substrate, and their mechanical strength and thermal shock resistance were tested. (orig.)

  6. Purification and characterization of Cc-Lec, C-type lactose-binding lectin: A platelet aggregation and blood-clotting inhibitor from Cerastes cerastes venom.

    Science.gov (United States)

    Samah, Saoud; Fatah, Chérifi; Jean-Marc, Berjeaud; Safia, Kellou-Taîri; Fatima, Laraba-Djebari

    2017-09-01

    In this study, we reported for the first time the biochemical and structural characterization of Cc-Lec, a C-type lectin purified from Cerastes cerastes venom by affinity chromatography. This lectin was homogeneous by SDS-PAGE, and was shown to be a 34 271.59Da polypeptide by Electrospray mass spectrometry MS-ES-TOF. Its identified sequence of 160 amino acids corresponding to one subunit, revealed a high identity with other related proteins. Cc-Lec modeled 3D structure appeared as homodimer cross-linked by one disulfide bridge. Cc-Lec exhibited a calcium dependent hemagglutinating activity against human group O erythrocytes. Cc-Lec inhibited platelet aggregation induced by ADP, arachidonic acid or fibrinogen suggesting its interaction with their specific receptors namely P2Y1 and/or P2Y12, GPIIb/IIIa and TPα respectively. Cc-Lec was not lethal for mice until 10mg/kg administered by i.p. route. The lectin displayed a lasting anticoagulation on mice plasma even two days post-injection. This anticoagulation seems to be related to its interaction with coagulation factors Xa and IXa. Therefore, Cc-Lec prevented FXa amidolytic activity with Km=4.3310 -4 μg/mL and ki=14.4μg/mL. It seems to interact with these targets through CRD domain which could make it a good target as a pharmacological promising molecule in thrombosis diagnosis and therapy. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Concholepas concholepas Ferritin H-like subunit (CcFer): Molecular characterization and single nucleotide polymorphism associated to innate immune response.

    Science.gov (United States)

    Chávez-Mardones, Jacqueline; Valenzuela-Muñoz, Valentina; Núñez-Acuña, Gustavo; Maldonado-Aguayo, Waleska; Gallardo-Escárate, Cristian

    2013-09-01

    Ferritin has been identified as the principal protein of iron storage and iron detoxification, playing a pivotal role for the cellular homeostasis in living organisms. However, recent studies in marine invertebrates have suggested its association with innate immune system. In the present study, one Ferritin subunit was identified from the gastropod Concholepas concholepas (CcFer), which was fully characterized by Rapid Amplification of cDNA Ends technique. Simultaneously, a challenge test was performed to evaluate the immune response against Vibrio anguillarum. The full length of cDNA Ccfer was 1030 bp, containing 513 bp of open reading frame that encodes to 170 amino acid peptide, which was similar to the Ferritin H subunit described in vertebrates. Untranslated Regions (UTRs) were identified with a 5'UTR of 244 bp that contains iron responsive element (IRE), and a 3'UTR of 273 bp. The predicted molecular mass of deduced amino acid of CcFer was 19.66 kDa and isoelectric point of 4.92. Gene transcription analysis revealed that CcFer increases against infections with V. anguillarum, showing a peak expression at 6 h post-infection. Moreover, a single nucleotide polymorphism was detected at -64 downstream 5'UTR sequence (SNP-64). Quantitative real time analysis showed that homozygous mutant allele (TT) was significantly associated with higher expression levels of the challenged group compared to wild (CC) and heterozygous (CT) variants. Our findings suggest that CcFer is associated to innate immune response in C. concholepas and that the presence of SNPs may involve differential transcriptional expression of CcFer. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Stopping test of iterative methods for solving PDE

    International Nuclear Information System (INIS)

    Wang Bangrong

    1991-01-01

    In order to assure the accuracy of the numerical solution of the iterative method for solving PDE (partial differential equation), the stopping test is very important. If the coefficient matrix of the system of linear algebraic equations is strictly diagonal dominant or irreducible weakly diagonal dominant, the stopping test formulas of the iterative method for solving PDE is proposed. Several numerical examples are given to illustrate the applications of the stopping test formulas

  9. On poisson-stopped-sums that are mixed poisson

    OpenAIRE

    Valero Baya, Jordi; Pérez Casany, Marta; Ginebra Molins, Josep

    2013-01-01

    Maceda (1948) characterized the mixed Poisson distributions that are Poisson-stopped-sum distributions based on the mixing distribution. In an alternative characterization of the same set of distributions here the Poisson-stopped-sum distributions that are mixed Poisson distributions is proved to be the set of Poisson-stopped-sums of either a mixture of zero-truncated Poisson distributions or a zero-modification of it. Peer Reviewed

  10. Stopping power, its meaning, and its general characteristics

    International Nuclear Information System (INIS)

    Inokuti, Mitio.

    1995-01-01

    This essay presents remarks on the meaning of stopping, power and of its magnitude. More precisely, the first set of remarks concerns the connection of stopping power with elements of particle-transport theory, which describes particle transport and its consequences in full detail, including its stochastic aspects. The second set of remarks concerns the magnitude of the stopping power of a material and its relation with the material's electronic structure and other properties

  11. Research of the stopping distance for different road conditions

    Directory of Open Access Journals (Sweden)

    Daniel LYUBENOV

    2011-01-01

    Full Text Available In this paper a modern method for determination of stopping distance is represented. Application of the non-contact VBOX 3i 100Hz GPS Data Logger speed and distance measurement system is represented. A description of the total stopping distance of vehicle main components - driver reaction time, vehicle reaction time and vehicle braking capability has been made. Research of the total stopping distance of a vehicle for different road conditions has been made. The results for the stopping distance can be very useful in the expert practice.

  12. The IAEA stopping power database, following the trends in stopping power of ions in matter

    Science.gov (United States)

    Montanari, C. C.; Dimitriou, P.

    2017-10-01

    The aim of this work is to present an overview of the state of art of the energy loss of ions in matter, based on the new developments in the stopping power database of the International Atomic Energy Agency (IAEA). This exhaustive collection of experimental data, graphs, programs and comparisons, is the legacy of Helmut Paul, who made it accessible to the global scientific community, and has been extensively employed in theoretical and experimental research during the last 25 years. The field of stopping power in matter is evolving, with new trends in materials of interest, including oxides, nitrides, polymers, and biological targets. Our goal is to identify areas of interest and emerging data needs to meet the requirements of a continuously developing user community.

  13. Clonal spread of MRSA CC398 sublineages within and between Danish pig farms

    DEFF Research Database (Denmark)

    Espinosa-Gongora, Carmen; Larsen, Jesper; Moodley, Arshnee

    Background: Methicillin-resistant Staphylococcus aureus (MRSA) CC398 is non-typeable by standard pulsed-field gel electrophoresis (PFGE) due to methylation of the SmaI site. This makes it difficult to study the epidemiology of this livestock-associated MRSA clone. In this study, we employed...... a recently developed PFGE protocol using Cfr9I, a neoschizomer of SmaI, to investigate the diversity of MRSA CC398 in Danish pig farms. The PFGE profiles displayed by isolates from pigs, environmental samples and farm workers were compared in order to understand whether farms are contaminated with multiple...... MRSA CC398 sublineages and whether specific sublineages may occur on different farms. Methods: A cross sectional study was performed in five Danish pig farms where farm workers had been shown to carry MRSA CC398 in the previous year. A total of 75 environmental and 308 animal samples were collected...

  14. Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2003

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2004-10-18

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCC Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed.

  15. Stress Effects on Stop Bursts in Five Languages

    Directory of Open Access Journals (Sweden)

    Marija Tabain

    2016-11-01

    Full Text Available This study examines the effects of stress on the stop burst in five languages differing in number of places of articulation, as reflected in burst duration, spectral centre of gravity, and ­spectral standard deviation. The languages studied are English (three places of articulation /p t k/, the Indonesian language Makasar (four places /p t c k/, and the Central Australian languages ­Pitjantjatjara, Warlpiri (both five places /p t ʈ c k/, and Arrernte (six places /p t̪ t ʈ c k/. We find that languages differ in how they manifest stress on the consonant, with Makasar not ­showing any effect of stress at all, and Warlpiri showing an effect on burst duration, but not on the ­spectral measures. For the other languages, the velar /k/ has a “darker” quality (i.e., lower spectral centre of gravity, and/or a less diffuse spectrum (i.e., lower standard deviation under stress; while the alveolar /t/ has a “lighter” quality under stress. In addition, the dental /t̪/ has a more diffuse spectrum under stress. We suggest that this involves enhancement of the features [grave] and [diffuse] under stress, with velars being [+grave] and [–diffuse], alveolars being [–grave], and dentals being [+diffuse]. We discuss the various possible spectral effects of enhancement of these features. Finally, in the languages with five or six places of articulation, the stop burst is longer only for the palatal /c/ and the velar /k/, which have intrinsically long burst durations, and not for the anterior coronals /t̪ t ʈ/, which have intrinsically short burst durations. We suggest that in these systems, [burst duration] is a feature that separates these two groups of consonants.

  16. The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.

    Directory of Open Access Journals (Sweden)

    Ruxandra Bachmann-Gagescu

    2015-10-01

    Full Text Available Ciliopathies are a group of human disorders caused by dysfunction of primary cilia, ubiquitous microtubule-based organelles involved in transduction of extra-cellular signals to the cell. This function requires the concentration of receptors and channels in the ciliary membrane, which is achieved by complex trafficking mechanisms, in part controlled by the small GTPase RAB8, and by sorting at the transition zone located at the entrance of the ciliary compartment. Mutations in the transition zone gene CC2D2A cause the related Joubert and Meckel syndromes, two typical ciliopathies characterized by central nervous system malformations, and result in loss of ciliary localization of multiple proteins in various models. The precise mechanisms by which CC2D2A and other transition zone proteins control protein entrance into the cilium and how they are linked to vesicular trafficking of incoming cargo remain largely unknown. In this work, we identify the centrosomal protein NINL as a physical interaction partner of CC2D2A. NINL partially co-localizes with CC2D2A at the base of cilia and ninl knockdown in zebrafish leads to photoreceptor outer segment loss, mislocalization of opsins and vesicle accumulation, similar to cc2d2a-/- phenotypes. Moreover, partial ninl knockdown in cc2d2a-/- embryos enhances the retinal phenotype of the mutants, indicating a genetic interaction in vivo, for which an illustration is found in patients from a Joubert Syndrome cohort. Similar to zebrafish cc2d2a mutants, ninl morphants display altered Rab8a localization. Further exploration of the NINL-associated interactome identifies MICAL3, a protein known to interact with Rab8 and to play an important role in vesicle docking and fusion. Together, these data support a model where CC2D2A associates with NINL to provide a docking point for cilia-directed cargo vesicles, suggesting a mechanism by which transition zone proteins can control the protein content of the ciliary

  17. Narrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A)

    OpenAIRE

    Whitehouse, AJ; Coon, H; Miller, J; Salisbury, B; Bishop, DV

    2010-01-01

    This study investigated whether the Communication Checklist – Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands and their parents. The CC-A is divided into subscales measuring linguistic ability as well as two aspects of social communication: the Pragmatic Skills subscale assesses the level of pragmatic oddities (e.g., excessive talking), while the Social Engagement subscale picks up on those behaviours that reflect a more passive communication st...

  18. Energy Materials Coordinating Committee (EMaCC). Annual technical report, Fiscal Year 2001

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2002-08-01

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations.

  19. Stress analysis of two-dimensional C/C composite components for HTGR's core restraint techanism

    International Nuclear Information System (INIS)

    Satoshi Hanawa; Taiju Shibata; Jyunya Sumita; Masahiro Ishihara; Tatsuo Iyoku; Kazuhiro Sawa

    2005-01-01

    Carbon fiber reinforced carbon matrix composite (C/C composite) is one of the most promising materials for HTGRs core components due to their high strength as well as high temperature resistibility. One of the most attractive applications of C/C composite is the core restraint mechanism. The core restraint mechanism is located around the reflector block and it works to tighten reactor core blocks so as to restrict un-supposition flow pass of coolant gas (bypass flow) in the core. The restriction of bypass flow reads to the high efficiency of coolant flow rate inside of the reactor core. For the future HTGRs and VHTR (Very High Temperature Reactor), it is important to develop the core restraint mechanism with C/C composite substitute for metallic materials as used for HTTR. For the application of C/C composite to core restraint mechanism, it is important to investigate the applicability of C/C composite in viewpoint of structural integrity. In the present study, supposing the application of 2D-C/C composite to core restraint mechanism, thermal stress behavior was analyzed by considering the thickness of the C/C composite and the gap between reflector block and core restraint. It was shown from the thermal stress analysis that the circumferential stress decreases with increasing the gap and that the restraint force increases with increasing the thickness. By optimizing the thickness of C/C composite and gap between reflector block and core restraint, the C/C composite is applicable to the core restraint mechanism. (authors)

  20. Engineering of Olfactory Receptor OlfCc1 for Directed Ligand Sensitivity

    OpenAIRE

    Berke, Allison Paige

    2013-01-01

    Abstract Engineering of Olfactory Receptor OlfCc1 for Directed Ligand Sensitivityby Allison Paige Berke Joint Doctor of Philosophywith the University of California San FranciscoUniversity of California, Berkeley Professor Song Li, ChairDue to structural similarity, OlfCc1and its mammalian analogue V2R2 are hypothesized to respond to amino acid ligands in a calcium-mediated fashion. By analyzing receptor structure and making targeted mutations, the specificity and sensitivity of the receptor s...

  1. Migrating C/C++ Software to Mobile Platforms in the ADM Context

    Directory of Open Access Journals (Sweden)

    Liliana Martinez

    2017-03-01

    Full Text Available Software technology is constantly evolving and therefore the development of applications requires adapting software components and applications in order to be aligned to new paradigms such as Pervasive Computing, Cloud Computing and Internet of Things. In particular, many desktop software components need to be migrated to mobile technologies. This migration faces many challenges due to the proliferation of different mobile platforms. Developers usually make applications tailored for each type of device expending time and effort. As a result, new programming languages are emerging to integrate the native behaviors of the different platforms targeted in development projects. In this direction, the Haxe language allows writing mobile applications that target all major mobile platforms. Novel technical frameworks for information integration and tool interoperability such as Architecture-Driven Modernization (ADM proposed by the Object Management Group (OMG can help to manage a huge diversity of mobile technologies. The Architecture-Driven Modernization Task Force (ADMTF was formed to create specifications and promote industry consensus on the modernization of existing applications. In this work, we propose a migration process from C/C++ software to different mobile platforms that integrates ADM standards with Haxe. We exemplify the different steps of the process with a simple case study, the migration of “the Set of Mandelbrot” C++ application. The proposal was validated in Eclipse Modeling Framework considering that some of its tools and run-time environments are aligned with ADM standards.

  2. {sup 68}Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients

    Energy Technology Data Exchange (ETDEWEB)

    Sathekge, Mike; Lengana, Thabo; Modiselle, Moshe; Vorster, Mariza; Zeevaart, JanRijn; Ebenhan, Thomas [University of Pretoria and Steve Biko Academic Hospital, Department of Nuclear Medicine, Pretoria (South Africa); Maes, Alex [University of Pretoria and Steve Biko Academic Hospital, Department of Nuclear Medicine, Pretoria (South Africa); AZ Groeninge, Department of Nuclear Medicine, Kortrijk (Belgium); Wiele, Christophe van de [University of Pretoria and Steve Biko Academic Hospital, Department of Nuclear Medicine, Pretoria (South Africa); University Ghent, Department of Radiology and Nuclear Medicine, Ghent (Belgium)

    2017-04-15

    To report on imaging findings using {sup 68}Ga-PSMA-HBED-CC PET in a series of 19 breast carcinoma patients. {sup 68}Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging examinations and analyzed as to lesion location and progesterone receptor status. Out of 81 tumor lesions identified, 84% were identified on {sup 68}Ga-PSMA-HBED-CC PET. {sup 68}Ga-PSMA-HBED-CC SUVmean values of distant metastases proved significantly higher (mean, 6.86, SD, 5.68) when compared to those of primary or local recurrences (mean, 2.45, SD, 2.55, p = 0.04) or involved lymph nodes (mean, 3.18, SD, 1.79, p = 0.011). SUVmean values of progesterone receptor-positive lesions proved not significantly different from progesterone receptor-negative lesions. SUV values derived from FDG PET/CT, available in seven patients, and {sup 68}Ga-PSMA-HBED-CC PET/CT imaging proved weakly correlated (r = 0.407, p = 0.015). {sup 68}Ga-PSMA-HBED-CC PET/CT imaging in breast carcinoma confirms the reported considerable variation of PSMA expression on human solid tumors using immunohistochemistry. (orig.)

  3. Improving Forecast Skill by Assimilation of AIRS Cloud Cleared Radiances RiCC

    Science.gov (United States)

    Susskind, Joel; Rosenberg, Robert I.; Iredell, Lena

    2015-01-01

    ECMWF, NCEP, and GMAO routinely assimilate radiosonde and other in-situ observations along with satellite IR and MW Sounder radiance observations. NCEP and GMAO use the NCEP GSI Data Assimilation System (DAS).GSI DAS assimilates AIRS, CrIS, IASI channel radiances Ri on a channel-by-channel, case-by-case basis, only for those channels i thought to be unaffected by cloud cover. This test excludes Ri for most tropospheric sounding channels under partial cloud cover conditions. AIRS Version-6 RiCC is a derived quantity representative of what AIRS channel i would have seen if the AIRS FOR were cloud free. All values of RiCC have case-by-case error estimates RiCC associated with them. Our experiments present to the GSI QCd values of AIRS RiCC in place of AIRS Ri observations. GSI DAS assimilates only those values of RiCC it thinks are cloud free. This potentially allows for better coverage of assimilated QCd values of RiCC as compared to Ri.

  4. The auditory-evoked N2 and P3 components in the stop-signal task: indices of inhibition, response-conflict or error-detection?

    Science.gov (United States)

    Dimoska, Aneta; Johnstone, Stuart J; Barry, Robert J

    2006-11-01

    The N2 and P3 components have been separately associated with response inhibition in the stop-signal task, and more recently, the N2 has been implicated in the detection of response-conflict. To isolate response inhibition activity from early sensory processing, the present study compared processing of the stop-signal with that of a task-irrelevant tone, which subjects were instructed to ignore. Stop-signals elicited a larger N2 on failed-stop trials and a larger P3 on successful-stop trials, relative to ignore-signal trials, likely reflecting activity related to failed and successful stopping, respectively. ERPs between fast and slow reaction-time (RT) groups were also examined as it was hypothesised that greater inhibitory activation to stop faster responses would manifest in the component reflecting this process. Successful-stop P3 showed the anticipated effect (globally larger amplitude in the fast than slow RT group), supporting its association with the stopping of an ongoing response. In contrast, N2 was larger in the slow than fast RT group, and in contrast to the predictions of the response-conflict hypothesis, successful-stop N2 and the response-locked error-negativity (Ne) differed in scalp distribution. These findings indicate that the successful-stop N2 may be better explained as a deliberate form of response control or selection, which the slow RT group employed as a means of increasing the likelihood of a successful-stop. Finally, a comparison of stimulus and response-locked ERPs revealed that the failed-stop N2 and P3 appeared to reflect error-related activity, best observed in the response-locked Ne and error-positivity (Pe). Together these findings indicate that the successful-stop N2 and P3 reflect functionally distinct aspects of response control that are dependent upon performance strategies, while failed-stop N2 and P3 reflect error-related activity.

  5. A nurse-led 'stop smoking' initiative.

    Science.gov (United States)

    McGowan, E; MacAuley, D; Anderson, U

    A one-week smoking awareness initiative and subsequent audit in a general practice are described. All patients attending morning surgery during the study period were offered the opportunity to discuss smoking habits at a smoking awareness clinic: 84 smokers attended. They were interviewed by the practice preventive care nurse who took a smoking history, monitored carbon monoxide (CO Hb) levels and offered a follow-up appointment. CO Hb provided immediate feedback on the effect of smoking and patients who smoked 20 or more cigarettes per day had an average CO Hb of 16.1 per cent. Fifteen per cent of smokers made a commitment to stop smoking and agreed to attend follow-up clinics. A random sample (50) of attenders at the initial Smoking Awareness Clinic (84) were followed up by questionnaire six months later. There were 29 replies (58 per cent); 19 patients (65 per cent) found the visit to the clinic helpful, 14 (48 per cent) reduced the number of cigarettes they smoked, and 11 (38 per cent) altered some other aspect of their lifestyle, of whom four modified their diet and four increased exercise. Five patients claimed they had given up smoking.

  6. Range and stopping power for slow particles

    International Nuclear Information System (INIS)

    Bastiano, M.; Fernandez, J. E.; Molinari, V. G.

    1997-01-01

    Generally, the effects of thermal agitation and chemical bonding of the target atoms need to be taken into account to compute properly the range and stopping power of particles. These two effects, however, complicate very much the calculation of the above parameters, and for this reason are usually neglected. In fact, when the energy of the test particles (t.p.) is sufficiently high compared to the thermal or bonding energies, these two effects can be safely disregarded. When the energy of the t.p. is of the same order of the thermal agitation or the chemical bonding, on the other hand, such approximation is not realistic, and to obtain meaningful results one must take into account the velocity distribution of the field particles (f.p.). The aim of this paper is to present a simple model describing the transport of particles (e.g., electrons) in the thermal zone, considering the thermal agitation of f.p. with an arbitrary distribution. It will be shown that in the first part of the slowing down the kinetic energy of t.p. is partially transformed into temperature. In the second part, the temperature tends to reach the equilibrium temperature, while average velocity of t.p. becomes zero. (author)

  7. Towards the end of the technical stop

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    After several weeks of hard work, the short technical stop of the LHC accelerator is coming to an end. Following a very intense campaign to repair and retest many thousand high voltage connectors, the upgraded magnet protection system is being commissioned. During this period, the current in the main dipole and quadrupole magnets is carefully increased up to 6kA, required to collide protons at 7TeV centre-of-mass energy. This has been achieved for most of the sectors.   The parameters of the upgraded magnet protection system are accurately calibrated. This operation is needed in order for the magnet protection system to be triggered only when a real problem occurs. The system is now able to detect a transition from superconducting to normal conducting state of the superconducting cable joints between magnets, a necessary condition to operate the magnet system above 2kA. Highly accurate measurements of the joint resistances have been performed by stepping up the current to 5kA. The magnets and the...

  8. 49 CFR 37.201 - Intermediate and rest stops.

    Science.gov (United States)

    2010-10-01

    ... wheelchair, shall be permitted to leave and return to the bus on the same basis as other passengers. The... passenger to get on and off the bus at the stop (e.g., operate the lift and provide assistance with... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.201 Intermediate and rest stops. (a) Whenever an OTRB makes...

  9. Stop valve with automatic control and locking for nuclear reactors

    International Nuclear Information System (INIS)

    Chung, D.K.

    1980-01-01

    This invention generally concerns an automatic control and locking stop valve. Specifically it relates to the use of such a valve in a nuclear reactor of the type containing absorber elements supported by a fluid and intended for stopping the reactor in complete safety [fr

  10. Effect of Weight Transfer on a Vehicle's Stopping Distance.

    Science.gov (United States)

    Whitmire, Daniel P.; Alleman, Timothy J.

    1979-01-01

    An analysis of the minimum stopping distance problem is presented taking into account the effect of weight transfer on nonskidding vehicles and front- or rear-wheels-skidding vehicles. Expressions for the minimum stopping distances are given in terms of vehicle geometry and the coefficients of friction. (Author/BB)

  11. STOP4-7 Nederland. Resultaten 2010-2011

    NARCIS (Netherlands)

    Geijsen, L.; Veerman, J.W.; Bastiaanssen, I.L.W.

    2011-01-01

    STOP4-7 is een multimodale interventie voor kinderen van 4 tot 7 jaar met ernstige externaliserende gedragsproblemen en hun opvoeders en leerkrachten. Het doel van STOP4-7 is het aanleren en versterken van sociale en probleemoplossende vaardigheden en het verminderen van ongewenst gedrag. Daarvoor

  12. Ion Stopping Powers and Ranges Whenever You Need Them

    DEFF Research Database (Denmark)

    Bassler, Niels; Christensen, Casper; Tørresø, Jesper Rosholm

    A new app "Electronic Stopping Power" for Android mobile phones and tablets, looks up stopping powers using the ICRU 49 (protons and alphas) and the revised ICRU 73 (lithium and heavier ions) tables. In addition, also MSTAR and an implementation of the Bethe equation expanded to low energies...

  13. Note on measuring electronic stopping of slow ions

    Science.gov (United States)

    Sigmund, P.; Schinner, A.

    2017-11-01

    Extracting stopping cross sections from energy-loss measurements requires careful consideration of the experimental geometry. Standard procedures for separating nuclear from electronic stopping treat electronic energy loss as a friction force, ignoring its dependence on impact parameter. In the present study we find that incorporating this dependence has a major effect on measured stopping cross sections, in particular for light ions at low beam energies. Calculations have been made for transmission geometry, nuclear interactions being quantified by Bohr-Williams theory of multiple scattering on the basis of a Thomas-Fermi-Molière potential, whereas electronic interactions are characterized by Firsov theory or PASS code. Differences between the full and the restricted stopping cross section depend on target thickness and opening angle of the detector and need to be taken into account in comparisons with theory as well as in applications of stopping data. It follows that the reciprocity principle can be violated when checked on restricted instead of full electronic stopping cross sections. Finally, we assert that a seeming gas-solid difference in stopping of low-energy ions is actually a metal-insulator difference. In comparisons with experimental results we mostly consider proton data, where nuclear stopping is only a minor perturbation.

  14. Extensive Genomic Diversity among Bovine-Adapted Staphylococcus aureus: Evidence for a Genomic Rearrangement within CC97.

    Directory of Open Access Journals (Sweden)

    Kathleen E Budd

    Full Text Available Staphylococcus aureus is an important pathogen associated with both human and veterinary disease and is a common cause of bovine mastitis. Genomic heterogeneity exists between S. aureus strains and has been implicated in the adaptation of specific strains to colonise particular mammalian hosts. Knowledge of the factors required for host specificity and virulence is important for understanding the pathogenesis and management of S. aureus mastitis. In this study, a panel of mastitis-associated S. aureus isolates (n = 126 was tested for resistance to antibiotics commonly used to treat mastitis. Over half of the isolates (52% demonstrated resistance to penicillin and ampicillin but all were susceptible to the other antibiotics tested. S. aureus isolates were further examined for their clonal diversity by Multi-Locus Sequence Typing (MLST. In total, 18 different sequence types (STs were identified and eBURST analysis demonstrated that the majority of isolates grouped into clonal complexes CC97, CC151 or sequence type (ST 136. Analysis of the role of recombination events in determining S. aureus population structure determined that ST diversification through nucleotide substitutions were more likely to be due to recombination compared to point mutation, with regions of the genome possibly acting as recombination hotspots. DNA microarray analysis revealed a large number of differences amongst S. aureus STs in their variable genome content, including genes associated with capsule and biofilm formation and adhesion factors. Finally, evidence for a genomic arrangement was observed within isolates from CC97 with the ST71-like subgroup showing evidence of an IS431 insertion element having replaced approximately 30 kb of DNA including the ica operon and histidine biosynthesis genes, resulting in histidine auxotrophy. This genomic rearrangement may be responsible for the diversification of ST71 into an emerging bovine adapted subgroup.

  15. Inertial-confinement-fusion applications of ion-stopping theory

    International Nuclear Information System (INIS)

    More, R.M.; Lee, Y.T.; Bailey, D.S.

    1982-01-01

    Methods were developed to calculate: (1) the stopping power of a hot plasma target, (2) the charge-state of a fast ion projectile, and (3) the final disposition of the deposited energy. The first issue refers to the stopping power for protons. The proton stopping power is altered in high-density or high-temperature targets, especially at velocities below the stopping peak. The second issue concerns the application of a proton stopping curve to the arbitrary projectile. The third topic is more specialized to inertial fusion and concerns the partition of deposited energy between ion (nuclear motion) degrees of freedom and those corresponding to bound and free electrons. The question here is whether a thermal equilibrium plasma is produced

  16. Simulating fail-stop in asynchronous distributed systems

    Science.gov (United States)

    Sabel, Laura; Marzullo, Keith

    1994-01-01

    The fail-stop failure model appears frequently in the distributed systems literature. However, in an asynchronous distributed system, the fail-stop model cannot be implemented. In particular, it is impossible to reliably detect crash failures in an asynchronous system. In this paper, we show that it is possible to specify and implement a failure model that is indistinguishable from the fail-stop model from the point of view of any process within an asynchronous system. We give necessary conditions for a failure model to be indistinguishable from the fail-stop model, and derive lower bounds on the amount of process replication needed to implement such a failure model. We present a simple one-round protocol for implementing one such failure model, which we call simulated fail-stop.

  17. High fluence effects on ion implantation stopping and range

    International Nuclear Information System (INIS)

    Selvi, S.; Tek, Z.; Oeztarhan, A.; Akbas, N.; Brown, I.G.

    2005-01-01

    We have developed a code STOPPO which can be used to modify the more-widely used ion implantation codes to more accurately predict the mean nuclear and electronic stopping power, preferential sputtering and range of heavy ions in monatomic target materials. In our simulations an effective atomic number and effective atomic mass are introduced into conveniently available analytical stopping cross-sections and a better fitting function for preferential sputtering yield is carefully evaluated for each ion implantation. The accuracy of the code confirmed experimentally by comparison with measured Rutherford backscattering spectrometry (RBS) concentration profiles for 130 keV Zr ions implanted into Be to fluences of 1 x 10 17 , 2 x 10 17 and 4 x 10 17 ions/cm 2 . We find a steady increase in the mean nuclear and electronic stopping powers of the target; the increase in nuclear stopping power is much greater than the increase in electronic stopping power

  18. MOTIVASI, SIKAP, DAN INTENSI PENGGUNA MEDIA SOSIAL PADA KAMPANYE STOP ILLEGAL FISHING

    Directory of Open Access Journals (Sweden)

    La Moriansyah

    2016-11-01

    Full Text Available Social media is commonly used to promote social campaigns, one of which is Stop Illegal Fishing campaign. To achieve success in this campaign, some conditions have to be fulfilled i.e. positive attitudes of the social media users toward the campaigns and high intentions to provide recommendations (word of mouth to others. This study was conducted to analyze types of motivations affecting attitudes of users towards social campaigns (stop illegal fishing in social media. In addition, it also analyzed the influence of attitudes on users’ intentions in performing WOM. The method utilized to meet the objectives was Partial Least Square. The results showed that users’ motivation in using social media and towards the campaign messages are perceived to have significantly a positive effect on the attitude towards social campaigns in social media. Besides, the increase in the intention to perform WOM is positively influenced by the attitudes of social media users. There are differences identified in the motivation that affect the attitudes of social media users towards campaign of the two groups i.e. the social media users who have never seen the Stop Illegal Fishing campaign (151 samples and those who have seen the campaign in social media.    Keywords:  motivation, attitude, word of mouth, user experience, uses and gratification theory, digital campaigns, social campaigns, stop illegal fishingABSTRAKMedia sosial sering digunakan untuk mempromosikan kampanye sosial, contohnya adalah  kampanye Stop Illegal Fishing. Untuk meraih kesuksesan pada kampanye ini, beberapa hal yang harus diraih adalah sikap positif pengguna media sosial terhadap kampanye dan intensi yang tinggi untuk memberikan rekomendasi (word of mouth kepada orang lain. Penelitian ini dilakukan untuk menganalisis motivasi pengguna apa saja yang memengaruhi sikap pengguna media sosial terhadap kampanye sosial (stop illegal fishing di media sosial. Selain itu menganalisis sikap

  19. The global polio eradication initiative Stop Transmission of Polio (STOP) program - 1999-2013.

    Science.gov (United States)

    2013-06-21

    In 1988, the Global Polio Eradication Initiative (GPEI) was established through a partnership between the World Health Organization (WHO), Rotary International, CDC, and the United Nations Children's Fund (UNICEF). By 2012, the annual incidence of polio had decreased by >99%, compared with 1988, and the number of countries in which wild poliovirus (WPV) circulation has never been interrupted was reduced to three: Afghanistan, Nigeria, and Pakistan. However, because of the persistence of endemic WPV transmission and recurring outbreaks in polio-free countries after the original polio eradication target date of 2000, the World Health Assembly in 2012 declared the completion of polio eradication a programmatic emergency. A key component of GPEI is the Stop Transmission of Polio (STOP) program, which was developed and initiated by CDC with WHO in 1999 to mobilize additional human resources and technical assistance for countries affected by WPV transmission. During 1999-2013, 1,563 volunteers were identified, trained, and deployed for 2,221 assignments in 69 countries. The number of volunteers increased from 90-120 per year during 1999-2011 to 287 in 2012 and 378 in 2013, and the number of volunteer person-months in the field per year increased from 273 in 1999 to 1,456 in 2012. The STOP program has aided GPEI by strengthening the capacity of country-level immunization programs and by allowing a large cohort of volunteers to gain valuable field experience that prepares them well for subsequent work as staff members of WHO, UNICEF, and other public health agencies.

  20. Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media

    Directory of Open Access Journals (Sweden)

    Paloma I. Beamer

    2016-05-01

    Full Text Available Arsenic exposure has been associated with decreased club cell secretory protein (CC16 levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil (b = −0.43, p = 0.001, R2 = 0.08, water (b = −0.22, p = 0.07, R2 = 0.03, house dust (b = −0.37, p = 0.07, R2 = 0.04, and dust loading (b = −0.21, p = 0.04, R2 = 0.04. In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels (b = −0.42, p = 0.02, R2 = 0.14 (full model after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.

  1. New stopping rules for dendrogram classification in TWINSPAN

    Directory of Open Access Journals (Sweden)

    Omid Esmailzadeh

    2015-12-01

    Full Text Available The aim of this study is to propose a modification of TWINSPAN algorithm with introducing new stopping rules for TWINSPAN. Modified TWINSPAN combines the analysis of heterogeneity of the clusters prior to each division to prevent the imposed divisions of homogeneous clusters and it also solved the limitation of classical TWINSPAN in which the number of clusters increases power of two. For this purpose, ecological groups of Box tree stands in Farim forests were classified with using classical and modified TWINSPAN basis of plant species cover percentage of 60 plots with 400 m2 surface area which were made by releve method (by consideration of indicator stand concept. In this relation, five different heterogeneity measures including Whittaker’s beta diversity and total inertia, Sorensen, Jaccard and Orlo´ci dissimilarity indices which representing diversity and distance indices respectively were involved. Sample plots were also classified from basis of topographical properties using cluster analysis with emphasizing Euclidean distance coefficient and Wards clustering method. Results showed that using of two sets of heterogeneity indices lead to different classification dendrograms. In this relation, results of Whittaker’s beta with total inertia as diversity indices were similar and the other three dissimilarity indices have shown similar behavior. Finally, our results reiterated that modified TWINSPAN did not alter the logic of the TWINSPAN classification, but it increased the flexibility of TWINSPAN dendrogram with changing the hierarchy of divisions in the final classification of ecological groups of Box tree stands in Farim forests.

  2. Development of C/C composite for the core component of the high temperature gas cooled reactor

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. Y.; Kim, W. J.; Ryu, W. S.; Jang, J. H

    2005-01-15

    This report reviewed a state of the art on development of C/C composite for the core components for VHTR and described the followings items. The fabrication methods of C/C composites. Summary on the JAERI report (JAERI-Res 2002-026) on the process screening test for the selection of a proper C/C composite material. Review of the proceedings presented at the GEN-IV VHTR material PMB meeting. A status of the domestic commercial C/C composite. The published property data and the characteristics of the commercial C/C composite.

  3. Development of C/C composite for the core component of the high temperature gas cooled reactor

    International Nuclear Information System (INIS)

    Park, J. Y.; Kim, W. J.; Ryu, W. S.; Jang, J. H.

    2005-01-01

    This report reviewed a state of the art on development of C/C composite for the core components for VHTR and described the followings items. The fabrication methods of C/C composites. Summary on the JAERI report (JAERI-Res 2002-026) on the process screening test for the selection of a proper C/C composite material. Review of the proceedings presented at the GEN-IV VHTR material PMB meeting. A status of the domestic commercial C/C composite. The published property data and the characteristics of the commercial C/C composite

  4. Effectiveness of an online knowledge training and assessment program for stop smoking practitioners.

    Science.gov (United States)

    Brose, Leonie S; West, Robert; Michie, Susan; Kenyon, Jennifer A M; McEwen, Andy

    2012-07-01

    In English National Health Service (NHS) stop smoking services, stop smoking practitioners (SSPs) provide behavioral support and medication to support smokers wanting to quit. This study aimed to evaluate an evidence-based national online knowledge training program for SSPs developed by the NHS Centre for Smoking Cessation and Training (NCSCT). Knowledge required to deliver effective stop smoking interventions was assessed using 25 multiple-choice questions drawn randomly from a common larger pool at baseline and after use of the training program in 778 consecutive users. Change in knowledge and association of this change with time spent on the training were assessed. Baseline and change in knowledge of SSPs with different amounts of experience, prior training, and time dedicated to smoking cessation were compared. Knowledge improved from 64.4% correct to 77.7% (p < .001). Time spent on the training predicted improvement. Pretraining knowledge scores differed with experience, prior training, and time practicing. Training improved even the highest performing SSPs and minimized differences between groups. Knowledge required to deliver effective stop smoking intervention is improved efficiently by using the NCSCT online training program for English smoking cessation practitioners. SSPs with all levels of prior knowledge benefit.

  5. When to stop drying fruit: Insights from hygrothermal modelling

    International Nuclear Information System (INIS)

    Defraeye, Thijs

    2017-01-01

    Highlights: • Partial dehydration reduces energy consumption and processing time and improves product quality. • This study gives a quantitative insight in when fruit drying should be stopped. • Decrease in dryer residence time of 2%, 24% and 70% are found for different stopping criteria. - Abstract: Stopping the drying process prior to complete dehydration reduces energy consumption and processing time but can also improve product quality. Using hygrothermal simulations, different stopping criteria are evaluated, which are based on the final water activity and residual moisture content in the fruit. Their impact on drying time and moisture redistribution kinetics inside fruit is quantified. One of the variants leads to a significant reduction in residence time in the dryer (24%), compared to full dehydration. For this variant, drying is stopped when the average moisture content in the sample reaches the value corresponding to an equilibrium water activity of 60% in the sample, as determined from the sorption isotherm. At the same time, this variant does not induce problems with fruit spoilage, as a sufficiently low water activity is reached after moisture redistribution during relaxation in the ambient environment. In addition, the relation of the drying time to the drying air temperature was quantified for all stopping criteria, as well as the impact of the humidity of the ambient environment in which the dried fruits are placed afterwards. This study gives a better quantitative insight in when fruit drying should be stopped, given specific drying conditions, without having to compromise food safety.

  6. Overexpression of the CC-type glutaredoxin, OsGRX6 affects hormone and nitrogen status in rice plants

    Directory of Open Access Journals (Sweden)

    Ashraf eEl-Kereamy

    2015-11-01

    Full Text Available Glutaredoxins (GRXs are small glutathione dependent oxidoreductases that belong to the Thioredoxin (TRX superfamily and catalyze the reduction of disulfide bonds of their substrate proteins. Plant GRXs include three different groups based on the motif sequence, namely CPYC, CGFS and CC-type proteins. The rice CC-type proteins, OsGRX6 was identified during the screening for genes whose expression changes depending on the level of available nitrate. Overexpression of OsGRX6 in rice displayed a semi-dwarf phenotype. The OsGRX6 overexpressors contain a higher nitrogen content than the wild type, indicating that OsGRX6 plays a role in homeostatic regulation of nitrogen use. Consistent with this, OsGRX6 overexpressors displayed delayed chlorophyll degradation and senescence compared to the wild type plants. To examine if the growth defect of these transgenic lines attribute to disturbed plant hormone actions, plant hormone levels were measured. The levels of two cytokinins (CKs, 2-isopentenyladenine and trans-zeatin, and gibberellin A1 (GA1 were increased in these lines. We also found that these transgenic lines were less sensitive to exogenously applied GA, suggesting that the increase in GA1 is a result of the feedback regulation. These data suggest that OsGRX6 affects hormone signaling and nitrogen status in rice plants.

  7. Optical implementation of (3, 3, 2) regular rectangular CC-Banyan optical network

    Science.gov (United States)

    Yang, Junbo; Su, Xianyu

    2007-07-01

    CC-Banyan network plays an important role in the optical interconnection network. Based on previous reports of (2, 2, 3) the CC-Banyan network, another rectangular-Banyan network, i.e. (3, 3, 2) rectangular CC-Banyan network, has been discussed. First, according to its construction principle, the topological graph and the routing rule of (3, 3, 2) rectangular CC-Banyan network have been proposed. Then, the optically experimental setup of (3, 3, 2) rectangular CC-Banyan network has been designed and achieved. Each stage of node switch consists of phase spatial light modulator (PSLM) and polarizing beam-splitter (PBS), and fiber has been used to perform connection between adjacent stages. PBS features that s-component (perpendicular to the incident plane) of the incident light beam is reflected, and p-component (parallel to the incident plane) passes through it. According to switching logic, under the control of external electrical signals, PSLM functions to control routing paths of the signal beams, i.e. the polarization of each optical signal is rotated or not rotated 90° by a programmable PSLM. Finally, the discussion and analysis show that the experimental setup designed here can realize many functions such as optical signal switch and permutation. It has advantages of large number of input/output-ports, compact in structure, and low energy loss. Hence, the experimental setup can be used in optical communication and optical information processing.

  8. Cloning and bioinformatics analysis of CcPILS gene of Hickory (Carya cathayensis)

    Science.gov (United States)

    Guo, Wenbin; Yuan, Huwei; Gao, Liuxiao; Guo, Haipeng; Qiu, Lingling; Xu, Dongbin; Yan, Daoliang; Zheng, Bingsong

    2017-04-01

    PILS is a key auxin efflux carrier protein in the auxin signal transduction. A CcPILS gene related to hickory (Carya carthayensis) grafting process was obtained by RACE techniques. The full length of CcPILS gene was1541bp contained a 1263bp length open reading flame (ORF). The CcPILS encoded 294 amino acids with molecular weight of 46 kDa, PI 5.38 and localized at endoplasmic reticulum membrane. The gene contained a central hydrophilic loop separating two hydrophobic domains of about five transmembrane regions each. The gene of CcPILS belonged to Clade III sub-family of PILS and its sequence had high homology with Arabidopsis. Real Time RT-PCR analysis showed that the gene expressions were weakly induced in bud, inflorescence, fruit, leaf and stem, while strongly in root. The expression levels were strongly induced and reached a peak at the third day of grafting in scion and rootstock of hickory, which were 1.45 and 3.45 times higher, respectively, compared to that of control. The results indicated that CcPILS may be involved in regulating the expression of genes related to auxin signal transduction during hickory graft process.

  9. Irradiation effects on C/C composite materials for high temperature nuclear applications

    International Nuclear Information System (INIS)

    Eto, M.; Ugachi, H.; Baba, S.I.; Ishiyama, S.; Ishihara, M.; Hayashi, K.

    2000-01-01

    Excellent characteristics such as high strength and high thermal shock resistance of C/C composite materials have led us to try to apply them to the high temperature components in nuclear facilities. Such components include the armour tile of the first wall and divertor of fusion reactor and the elements of control rod for the use in HTGR. One of the most important aspects to be clarified about C/C composites for nuclear applications is the effect of neutron irradiation on their properties. At the Japan Atomic Energy Research Institute (JAERI), research on the irradiation effects on various properties of C/C composite materials has been carried out using fission reactors (JRR-3, JMTR), accelerators (TANDEM, TIARA) and the Fusion Neutronics Source (FNS). Additionally, strength tests of some neutron-irradiated elements for the control rod were carried out to investigate the feasibility of C/C composites. The paper summarises the R and D activities on the irradiation effects on C/C composites. (authors)

  10. Rapid Differentiation between Livestock-Associated and Livestock-Independent Staphylococcus aureus CC398 Clades

    Science.gov (United States)

    Larsen, Jesper; Soldanova, Katerina; Aziz, Maliha; Contente-Cuomo, Tania; Petersen, Andreas; Vandendriessche, Stien; Jiménez, Judy N.; Mammina, Caterina; van Belkum, Alex; Salmenlinna, Saara; Laurent, Frederic; Skov, Robert L.; Larsen, Anders R.; Andersen, Paal S.; Price, Lance B.

    2013-01-01

    Staphylococcus aureus clonal complex 398 (CC398) isolates cluster into two distinct phylogenetic clades based on single-nucleotide polymorphisms (SNPs) revealing a basal human clade and a more derived livestock clade. The scn and tet(M) genes are strongly associated with the human and the livestock clade, respectively, due to loss and acquisition of mobile genetic elements. We present canonical single-nucleotide polymorphism (canSNP) assays that differentiate the two major host-associated S. aureus CC398 clades and a duplex PCR assay for detection of scn and tet(M). The canSNP assays correctly placed 88 S. aureus CC398 isolates from a reference collection into the human and livestock clades and the duplex PCR assay correctly identified scn and tet(M). The assays were successfully applied to a geographically diverse collection of 272 human S. aureus CC398 isolates. The simple assays described here generate signals comparable to a whole-genome phylogeny for major clade assignment and are easily integrated into S. aureus CC398 surveillance programs and epidemiological studies. PMID:24244535

  11. Stigma-Stop: A Serious Game against the Stigma toward Mental Health in Educational Settings

    Directory of Open Access Journals (Sweden)

    Adolfo J. Cangas

    2017-08-01

    Full Text Available This paper presents the results from the application of a serious game called Stigma-Stop among a group of high school students with the aim of reducing the stigma toward mental illnesses. The video game features characters with various mental disorders (schizophrenia, depression, bipolar disorder, and panic disorder with agoraphobia and provides information about these problems. Additionally, the game asks players about whether they have ever felt the same as the characters, if they believe the characters are psychologically well, and if they think they could help these individuals. Similarly, a variety of reactions are provided for players to choose from when they encounter the characters with these problems. A total of 552 students between the ages of 14 and 18 participated in the study, and they were randomly assigned to either the experimental group, which used Stigma-Stop, or the control group, which utilized a video game completely unrelated to mental health. Both video games were used for similar lengths of time. Following the application of Stigma-Stop, a statistically significant decrease was obtained in levels of stigma toward schizophrenia, both in terms of stereotypes and, to a greater extent, its potential dangerousness. However, this was not the case in the control group. Results thus demonstrate the video game’s usefulness toward eradicating erroneous notions about serious mental disorders like schizophrenia.

  12. Stigma-Stop: A Serious Game against the Stigma toward Mental Health in Educational Settings.

    Science.gov (United States)

    Cangas, Adolfo J; Navarro, Noelia; Parra, José M A; Ojeda, Juan J; Cangas, Diego; Piedra, Jose A; Gallego, Jose

    2017-01-01

    This paper presents the results from the application of a serious game called Stigma-Stop among a group of high school students with the aim of reducing the stigma toward mental illnesses. The video game features characters with various mental disorders (schizophrenia, depression, bipolar disorder, and panic disorder with agoraphobia) and provides information about these problems. Additionally, the game asks players about whether they have ever felt the same as the characters, if they believe the characters are psychologically well, and if they think they could help these individuals. Similarly, a variety of reactions are provided for players to choose from when they encounter the characters with these problems. A total of 552 students between the ages of 14 and 18 participated in the study, and they were randomly assigned to either the experimental group, which used Stigma-Stop, or the control group, which utilized a video game completely unrelated to mental health. Both video games were used for similar lengths of time. Following the application of Stigma-Stop, a statistically significant decrease was obtained in levels of stigma toward schizophrenia, both in terms of stereotypes and, to a greater extent, its potential dangerousness. However, this was not the case in the control group. Results thus demonstrate the video game's usefulness toward eradicating erroneous notions about serious mental disorders like schizophrenia.

  13. Does Core Length Taken per cc of Prostate Volume in Prostate Biopsy Affect the Diagnosis of Prostate Cancer?

    Science.gov (United States)

    Deliktas, Hasan; Sahin, Hayrettin; Cetinkaya, Mehmet; Dere, Yelda; Erdogan, Omer; Baldemir, Ercan

    2016-08-01

    The aim of this study was to determine the minimal core length to be taken per cc of prostate volume for an effective prostate biopsy. A retrospective analysis was performed on the records of 379 patients who underwent a first prostate biopsy with 12 to 16 cores under transrectal ultrasound guidance between September 2012 and April 2015. For each patient, the core length per cc of the prostate and the percentage of sampled prostate volume were calculated, and these values were compared between the patients with and without prostate cancer. A total of 348 patients were included in the study. Cancer was determined in 26.4% of patients. The mean core length taken per cc of prostate and the percentage of sampled prostate volume were determined to be 3.40 ± 0.15 mm/cc (0.26%; range, 0.08-0.63 cc) in patients with cancer and 2.75 ± 0.08 mm/cc (0.20%; range, 0.04-0.66 cc) in patients without cancer (P = .000 and P = .000), respectively. Core length taken per cc of prostate of > 3.31 mm/cc was found to be related to an increase in the rates of prostate cancer diagnosis (odds ratio, 2.84; 95% confidence interval, 1.68-4.78). The rate of cancer determination for core length taken per cc of prostate of  3.31 mm/cc, 41.1%. Core length taken per cc of prostate and the percentage of sampled prostate volume are important morphometric parameters in the determination of prostate cancer. The results of study suggest a core length per cc of the prostate of > 3.31 mm/cc as a cutoff value for quality assurance. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. STARCODES, Stopping Power and Ranges for Electrons, Protons, He

    International Nuclear Information System (INIS)

    2000-01-01

    1 - Description of program or function: The 'STAR CODES', ESTAR, PSTAR, and ASTAR, calculate stopping-power and range tables for electrons, protons, and helium ions (alphas), according to methods described in ICRU Reports 37 and 39. 2 - Method of solution: Collision stopping powers are calculated from the theory of Bethe (1930, 1932), with a density-effect correction evaluated according to Sternheimer (1952, 1982). The stopping-power formula contains an important parameter, the mean excitation energy (I-value), which characterizes the stopping properties of a material. The codes provide output for electrons in any stopping material (279 provided) and for protons and helium ions in 74 materials. The calculations include the 1) Collision stopping power, 2) Radiative stopping power (electrons only), 3) Nuclear stopping power (protons and helium ions), 4) Total stopping power, 5) CSDA range, 6) Projected range (protons and helium ions), 7) Density effect parameter (electrons), 8) Radiation yield (electrons), and 9) Detour factor (protons and helium ions). Standard energy grids and files of elements w/ionization-excitation information are included with lookup table capabilities. 3 - Restrictions on the complexity of the problem: The minimum energies used in the calculations are at 1 KeV (protons and helium ions) and 10 KeV (electrons), and the maximum are 1 GeV. The standard energy grids are set at 81 for electrons, equally spaced (logarithmically), 133 for protons, and 122 for helium ions. The lower energy electron calculations (< 10 KeV) have up to 5-10% errors and are considered too fallable

  15. Stop search in the compressed region via semileptonic decays

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Hsin-Chia; Gao, Christina; Li, Lingfeng; Neill, Nicolás A. [Department of Physics, University of California,Davis, California 95616 (United States)

    2016-05-05

    In supersymmetric extensions of the Standard Model, the superpartners of the top quark (stops) play the crucial role in addressing the naturalness problem. For direct pair-production of stops with each stop decaying into a top quark plus the lightest neutralino, the standard stop searches have difficulty finding the stop for a compressed spectrum where the mass difference between the stop and the lightest neutralino is close to the top quark mass, because the events look too similar to the large tt̄ background. With an additional hard ISR jet, the two neutralinos from the stop decays are boosted in the opposite direction and they can give rise to some missing transverse energy. This may be used to distinguish the stop decays from the backgrounds. In this paper we study the semileptonic decay of such signal events for the compressed mass spectrum. Although the neutrino from the W decay also produces some missing transverse energy, its momentum can be reconstructed from the kinematic assumptions and mass-shell conditions. It can then be subtracted from the total missing transverse momentum to obtain the neutralino contribution. Because it suffers from less backgrounds, we show that the semileptonic decay channel has a better discovery reach than the fully hadronic decay channel along the compressed line m{sub t̃}−m{sub χ̃}≈m{sub t}. With 300 fb{sup −1}, the 13 TeV LHC can discover the stop up to 500 GeV, covering the most natural parameter space region.

  16. The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation.

    Science.gov (United States)

    Basel-Vanagaite, L; Attia, R; Yahav, M; Ferland, R J; Anteki, L; Walsh, C A; Olender, T; Straussberg, R; Magal, N; Taub, E; Drasinover, V; Alkelai, A; Bercovich, D; Rechavi, G; Simon, A J; Shohat, M

    2006-03-01

    The molecular basis of autosomal recessive non-syndromic mental retardation (NSMR) is poorly understood, mostly owing to heterogeneity and absence of clinical criteria for grouping families for linkage analysis. Only two autosomal genes, the PRSS12 gene on chromosome 4q26 and the CRBN on chromosome 3p26, have been shown to cause autosomal recessive NSMR, each gene in only one family. To identify the gene causing autosomal recessive NSMR on chromosome 19p13.12. The candidate region established by homozygosity mapping was narrowed down from 2.4 Mb to 0.9 Mb on chromosome 19p13.12. A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive NSMR. The absence of the wild type protein in the lymphoblastoid cells of the patients was confirmed. CC2D1A is a member of a previously uncharacterised gene family that carries two conserved motifs, a C2 domain and a DM14 domain. The C2 domain is found in proteins which function in calcium dependent phospholipid binding; the DM14 domain is unique to the CC2D1A protein family and its role is unknown. CC2D1A is a putative signal transducer participating in positive regulation of I-kappaB kinase/NFkappaB cascade. Expression of CC2D1A mRNA was shown in the embryonic ventricular zone and developing cortical plate in staged mouse embryos, persisting into adulthood, with highest expression in the cerebral cortex and hippocampus. A previously unknown signal transduction pathway is important in human cognitive development.

  17. The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non‐syndromic mental retardation

    Science.gov (United States)

    Basel‐Vanagaite, L; Attia, R; Yahav, M; Ferland, R J; Anteki, L; Walsh, C A; Olender, T; Straussberg, R; Magal, N; Taub, E; Drasinover, V; Alkelai, A; Bercovich, D; Rechavi, G; Simon, A J; Shohat, M

    2006-01-01

    Background The molecular basis of autosomal recessive non‐syndromic mental retardation (NSMR) is poorly understood, mostly owing to heterogeneity and absence of clinical criteria for grouping families for linkage analysis. Only two autosomal genes, the PRSS12 gene on chromosome 4q26 and the CRBN on chromosome 3p26, have been shown to cause autosomal recessive NSMR, each gene in only one family. Objective To identify the gene causing autosomal recessive NSMR on chromosome 19p13.12. Results The candidate region established by homozygosity mapping was narrowed down from 2.4 Mb to 0.9 Mb on chromosome 19p13.12. A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive NSMR. The absence of the wild type protein in the lymphoblastoid cells of the patients was confirmed. CC2D1A is a member of a previously uncharacterised gene family that carries two conserved motifs, a C2 domain and a DM14 domain. The C2 domain is found in proteins which function in calcium dependent phospholipid binding; the DM14 domain is unique to the CC2D1A protein family and its role is unknown. CC2D1A is a putative signal transducer participating in positive regulation of I‐κB kinase/NFκB cascade. Expression of CC2D1A mRNA was shown in the embryonic ventricular zone and developing cortical plate in staged mouse embryos, persisting into adulthood, with highest expression in the cerebral cortex and hippocampus. Conclusions A previously unknown signal transduction pathway is important in human cognitive development. PMID:16033914

  18. IFN-Alpha receptor-1 upregulation in PBMC from HCV naïve patients carrying cc genotype. possible role of IFN-lambda.

    Directory of Open Access Journals (Sweden)

    Eleonora Lalle

    Full Text Available IL-28B gene polymorphisms predict better therapeutic response and spontaneous clearance of HCV. Moreover, higher expression of IFN-lambda has been reported in patients with the rs12979860 CC favourable genotype. The study aim was to establish possible relationships between IL-28B rs12979860 genotypes and expression of IFN-alpha receptor-1 (IFNAR-1 in naïve HCV patients, and to explore the possible role of IFN-lambda.IFNAR-1 mRNA levels were measured in PBMC from naïve patients with chronic hepatitis C with different IL-28 genotypes. The ability of IFN-lambda to up-regulate the expression of IFNAR-1 was established in PBMC from healthy donors carrying different IL-28B genotypes.Lower IFNAR-1 mRNA levels were observed in PBMC from HCV-infected naïve patients as compared to healthy donors. In healthy donors, IFNAR-1 mRNA levels were independent from IL-28B genotype, while in HCV patients, an increasing gradient was observed in TT vs CT vs CC carriers. In the latter group, a direct correlation between IFNAR-1 and endogenous IL-28B expression was observed. Moreover, IFN-lambda up-regulated IFNAR-1 expression in normal PBMC in a time-and dose-dependent manner, with a more effective response in CC vs TT carriers.Endogenous levels of IFN-lambda may be responsible for partial restoration of IFNAR-1 expression in HCV patients with favourable IL-28 genotype. This, in turn, may confer to CC carriers a response advantage to either endogenous or exogenous IFN-alpha, representing the biological basis for the observed association between CC genotype and favourable outcome of either natural infection (clearance vs chronicization or IFN therapy.

  19. Stopping power. Projectile and target modeled as oscillators

    International Nuclear Information System (INIS)

    Stevanovic, N.; Nikezic, D.

    2005-01-01

    In this Letter the collision of two quantum harmonic oscillators was considered. The oscillators interact through the Coulomb interaction. Stopping power of projectile was calculated assuming that both, target and projectile may be excited. It has been shown that the frequency of the projectile oscillation, ω p influences on stopping power, particularly in the region of Bragg peak. If, ω p ->0 is substitute in the expression for stopping power derived in this Letter, then it comes to the form when the projectile has been treated as point like charged particle

  20. ELectron stopping of heavy ions in a matter

    International Nuclear Information System (INIS)

    Akhiezer, I.A.; Davydov, L.N.

    1978-01-01

    The theory of heavy ion stopping by electrons in solids is analyzed with an aim to establish which physical mechanisms are of importance at different ion velocity values v. The theory is presented for deep inelastic collisions taking the main part in stopping at v > Zsub(1)sup(1/3) v 0 (z 1 is the atomic number of the ion, v 0 is the Bohr velocity). Elastic scattering (relative to the incident ion) are investigated. It is shown that the contribution from these processes to the stopping cross-section is predominant at Zsub(1)sup(1/3) v 0 > v > Zsub(1)sup(2/3) v 0

  1. A Phonemic and Acoustic Analysis of Hindko Oral Stops

    Directory of Open Access Journals (Sweden)

    Haroon Ur RASHID

    2014-12-01

    Full Text Available Hindko is an Indo-Aryan language that is mainly spoken in Khyber Pukhtoonkhaw province of Pakistan. This work aims to identify the oral stops of Hindko and determine the intrinsic acoustic cues for them. The phonemic analysis is done with the help of minimal pairs and phoneme distribution in contrastive environments which reveals that Hindko has twelve oral stops with three way series. The acoustic analysis of these segments shows that intrinsically voice onset time (VOT, closure duration and burst are reliable and distinguishing cues of stops in Hindko.

  2. Coefficient αcc in design value of concrete compressive strength

    Directory of Open Access Journals (Sweden)

    Goleš Danica

    2016-01-01

    Full Text Available Coefficient αcc introduces the effects of rate and duration of loading on compressive strength of concrete. These effects may be partially or completely compensated by the increase in concrete strength over time. Selection of the value of this coefficient, in recommended range between 0.8 and 1.0, is carried out through the National Annexes to Eurocode 2. This paper presents some considerations related to the introduction of this coefficient and its value adopted in some European countries. The article considers the effect of the adoption of conservative value αcc=0.85 on design value of compressive and flexural resistance of rectangular cross-section made of normal and high strength concrete. It analyzes the influence of different values of coefficient αcc on the area of reinforcement required to achieve the desired resistance of cross-section.

  3. Energy Materials Coordinating Committee (EMaCC): Annual technical report, fiscal year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-07-01

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department`s materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. This report summarizes EMaCC activities for FY 1993 and describes the materials research programs of various offices and divisions within the Department. The program descriptions consist of a funding summary for each Assistant Secretary office and the Office of Energy Research, and detailed project summaries with project goals and accomplishments. The FY 1993 budget summary table for DOE Materials Activities in each of the programs is presented.

  4. LHC Availability 2017: Technical Stop 2 to End of Standard Proton Physics

    CERN Document Server

    Todd, Benjamin; Apollonio, Andrea; Walsh, David John; CERN. Geneva. ATS Department

    2017-01-01

    This document summarises the LHC machine availability for the period of Technical Stop 2 (TS2) to the end of standard proton physics in 2017. This period was dedicated to proton physics with a bunch spacing of 25ns. This note has been produced and ratified by the Availability Working Group which has complied fault information for the period in question using the Accelerator Fault Tracker.

  5. Stopping-power and mass energy-absorption coefficient ratios for Solid Water

    International Nuclear Information System (INIS)

    Ho, A.K.; Paliwal, B.R.

    1986-01-01

    The AAPM Task Group 21 protocol provides tables of ratios of average restricted stopping powers and ratios of mean energy-absorption coefficients for different materials. These values were based on the work of Cunningham and Schulz. We have calculated these quantities for Solid Water (manufactured by RMI), using the same x-ray spectra and method as that used by Cunningham and Schulz. These values should be useful to people who are using Solid Water for high-energy photon calibration

  6. Stigma-Stop: A Serious Game against the Stigma toward Mental Health in Educational Settings

    OpenAIRE

    Cangas, Adolfo J.; Navarro, Noelia; Parra, Jos? M. A.; Ojeda, Juan J.; Cangas, Diego; Piedra, Jose A.; Gallego, Jose

    2017-01-01

    This paper presents the results from the application of a serious game called Stigma-Stop among a group of high school students with the aim of reducing the stigma toward mental illnesses. The video game features characters with various mental disorders (schizophrenia, depression, bipolar disorder, and panic disorder with agoraphobia) and provides information about these problems. Additionally, the game asks players about whether they have ever felt the same as the characters, if they believe...

  7. Direct approaches to nitriles via highly efficient nitrogenation strategy through C-H or C-C bond cleavage.

    Science.gov (United States)

    Wang, Teng; Jiao, Ning

    2014-04-15

    Because of the importance of nitrogen-containing compounds in chemistry and biology, organic chemists have long focused on the development of novel methodologies for their synthesis. For example, nitrogen-containing compounds show up within functional materials, as top-selling drugs, and as bioactive molecules. To synthesize these compounds in a green and sustainable way, researchers have focused on the direct functionalization of hydrocarbons via C-H or C-C bond cleavage. Although researchers have made significant progress in the direct functionalization of simple hydrocarbons, direct C-N bond formation via C-H or C-C bond cleavage remains challenging, in part because of the unstable character of some N-nucleophiles under oxidative conditions. The nitriles are versatile building blocks and precursors in organic synthesis. Recently, chemists have achieved the direct C-H cyanation with toxic cyanide salts in the presence of stoichiometric metal oxidants. In this Account, we describe recent progress made by our group in nitrile synthesis. C-H or C-C bond cleavage is a key process in our strategy, and azides or DMF serve as the nitrogen source. In these reactions, we successfully realized direct nitrile synthesis using a variety of hydrocarbon groups as nitrile precursors, including methyl, alkenyl, and alkynyl groups. We could carry out C(sp(3))-H functionalization on benzylic, allylic, and propargylic C-H bonds to produce diverse valuable synthetic nitriles. Mild oxidation of C═C double-bonds and C≡C triple-bonds also produced nitriles. The incorporation of nitrogen within the carbon skeleton typically involved the participation of azide reagents. Although some mechanistic details remain unclear, studies of these nitrogenation reactions implicate the involvement of a cation or radical intermediate, and an oxidative rearrangement of azide intermediate produced the nitrile. We also explored environmentally friendly oxidants, such as molecular oxygen, to make our

  8. Longitudinal study on transmission of MRSA CC398 within pig herds

    Directory of Open Access Journals (Sweden)

    Broens Els M

    2012-05-01

    Full Text Available Abstract Background Since the detection of MRSA CC398 in pigs in 2004, it has emerged in livestock worldwide. MRSA CC398 has been found in people in contact with livestock and thus has become a public health issue. Data from a large-scale longitudinal study in two Danish and four Dutch pig herds were used to quantify MRSA CC398 transmission rates within pig herds and to identify factors affecting transmission between pigs. Results Sows and their offspring were sampled at varying intervals during a production cycle. Overall MRSA prevalence of sows increased from 33% before farrowing to 77% before weaning. Overall MRSA prevalence of piglets was > 60% during the entire study period. The recurrent finding of MRSA in the majority of individuals indicates true colonization or might be the result of contamination. Transmission rates were estimated using a Susceptible-Infectious-Susceptible (SIS-model, which resulted in values of the reproduction ratio (R0 varying from 0.24 to 8.08. Transmission rates were higher in pigs treated with tetracyclins and β-lactams compared to untreated pigs implying a selective advantage of MRSA CC398 when these antimicrobials are used. Furthermore, transmission rates were higher in pre-weaning pigs compared to post-weaning pigs which might be explained by an age-related susceptibility or the presence of the sow as a primary source of MRSA CC398. Finally, transmission rates increased with the relative increase of the infection pressure within the pen compared to the total infection pressure, implying that within-pen transmission is a more important route compared to between-pen transmission and transmission through environmental exposure. Conclusion Our results indicate that MRSA CC398 is able to spread and persist in pig herds, resulting in an endemic situation. Transmission rates are affected by the use of selective antimicrobials and by the age of pigs.

  9. Efficient detection of dangling pointer error for C/C++ programs

    Science.gov (United States)

    Zhang, Wenzhe

    2017-08-01

    Dangling pointer error is pervasive in C/C++ programs and it is very hard to detect. This paper introduces an efficient detector to detect dangling pointer error in C/C++ programs. By selectively leave some memory accesses unmonitored, our method could reduce the memory monitoring overhead and thus achieves better performance over previous methods. Experiments show that our method could achieve an average speed up of 9% over previous compiler instrumentation based method and more than 50% over previous page protection based method.

  10. First measurement of the lifetime of the doubly charmed baryon $\\Xi_{cc}^{++}$

    CERN Document Server

    Aaij, Roel; LHCb Collaboration; Adinolfi, Marco; Aidala, Christine Angela; Ajaltouni, Ziad; Akar, Simon; Albicocco, Pietro; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Alfonso Albero, Alejandro; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Archilli, Flavio; d'Argent, Philippe; Arnau Romeu, Joan; Artamonov, Alexander; Artuso, Marina; Arzymatov, Kenenbek; Aslanides, Elie; Atzeni, Michele; Audurier, Benjamin; Bachmann, Sebastian; Back, John; Baker, Sophie; Balagura, Vladislav; Baldini, Wander; Baranov, Alexander; Barlow, Roger; Barsuk, Sergey; Barter, William; Baryshnikov, Fedor; Batozskaya, Varvara; Batsukh, Baasansuren; Battista, Vincenzo; Bay, Aurelio; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Beiter, Andrew; Bel, Lennaert; Beliy, Nikita; Bellee, Violaine; Belloli, Nicoletta; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Beranek, Sarah; Berezhnoy, Alexander; Bernet, Roland; Berninghoff, Daniel; Bertholet, Emilie; Bertolin, Alessandro; Betancourt, Christopher; Betti, Federico; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bezshyiko, Iaroslava; Bhasin, Srishti; Bhom, Jihyun; Bian, Lingzhu; Bifani, Simone; Billoir, Pierre; Birnkraut, Alex; Bizzeti, Andrea; Bjørn, Mikkel; Blago, Michele Piero; Blake, Thomas; Blanc, Frederic; Blusk, Steven; Bobulska, Dana; Bocci, Valerio; Boente Garcia, Oscar; Boettcher, Thomas; Bondar, Alexander; Bondar, Nikolay; Borghi, Silvia; Borisyak, Maxim; Borsato, Martino; Bossu, Francesco; Boubdir, Meriem; Bowcock, Themistocles; Bozzi, Concezio; Braun, Svende; Brodski, Michael; Brodzicka, Jolanta; Brossa Gonzalo, Arnau; Brundu, Davide; Buchanan, Emma; Buonaura, Annarita; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Byczynski, Wiktor; Cadeddu, Sandro; Cai, Hao; Calabrese, Roberto; Calladine, Ryan; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel Hugo; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Cattaneo, Marco; Cavallero, Giovanni; Cenci, Riccardo; Chamont, David; Chapman, Matthew George; Charles, Matthew; Charpentier, Philippe; Chatzikonstantinidis, Georgios; Chefdeville, Maximilien; Chekalina, Viktoriia; Chen, Chen; Chen, Shanzhen; Chitic, Stefan-Gabriel; Chobanova, Veronika; Chrzaszcz, Marcin; Chubykin, Alexsei; Ciambrone, Paolo; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Coelho, Joao A B; Cogan, Julien; Cogneras, Eric; Cojocariu, Lucian; Collins, Paula; Colombo, Tommaso; Comerma-Montells, Albert; Contu, Andrea; Coombs, George; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Costa Sobral, Cayo Mar; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Currie, Robert; D'Ambrosio, Carmelo; Da Cunha Marinho, Franciole; Da Silva, Cesar Luiz; Dall'Occo, Elena; Dalseno, Jeremy; Danilina, Anna; Davis, Adam; De Aguiar Francisco, Oscar; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Serio, Marilisa; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Del Buono, Luigi; Delaney, Blaise; Dembinski, Hans Peter; Demmer, Moritz; Dendek, Adam; Derkach, Denis; Deschamps, Olivier; Desse, Fabrice; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Nezza, Pasquale; Didenko, Sergey; Dijkstra, Hans; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Douglas, Lauren; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Durante, Paolo; Durham, John Matthew; Dutta, Deepanwita; Dzhelyadin, Rustem; Dziewiecki, Michal; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; Ely, Scott; Ene, Alexandru; Escher, Stephan; Esen, Sevda; Evans, Timothy; Falabella, Antonio; Farley, Nathanael; Farry, Stephen; Fazzini, Davide; Federici, Luca; Fernandez Declara, Placido; Fernandez Prieto, Antonio; Ferrari, Fabio; Ferreira Lopes, Lino; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fini, Rosa Anna; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Franco Lima, Vinicius; Frank, Markus; Frei, Christoph; Fu, Jinlin; Funk, Wolfgang; Färber, Christian; Féo Pereira Rivello Carvalho, Mauricio; Gabriel, Emmy; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gan, Yuyue; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garcia Martin, Luis Miguel; Garcia Plana, Beatriz; García Pardiñas, Julián; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gavardi, Laura; Gazzoni, Giulio; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Gerstel, Dawid; Ghez, Philippe; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gizdov, Konstantin; Gligorov, Vladimir; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gorelov, Igor Vladimirovich; Gotti, Claudio; Govorkova, Ekaterina; Grabowski, Jascha Peter; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greim, Roman; Griffith, Peter; Grillo, Lucia; Gruber, Lukas; Gruberg Cazon, Barak Raimond; Grünberg, Oliver; Gu, Chenxi; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Göbel, Carla; Hadavizadeh, Thomas; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hamilton, Brian; Han, Xiaoxue; Hancock, Thomas Henry; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Thomas; Hasse, Christoph; Hatch, Mark; He, Jibo; Hecker, Malte; Heinicke, Kevin; Heister, Arno; Hennessy, Karol; Henry, Louis; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hidalgo Charman, Raoul; Hill, Donal; Hilton, Martha; Hopchev, Plamen Hristov; Hu, Wenhua; Huang, Wenqian; Huard, Zachary; Hulsbergen, Wouter; Humair, Thibaud; Hushchyn, Mikhail; Hutchcroft, David; Hynds, Daniel; Ibis, Philipp; Idzik, Marek; Ilten, Philip; Ivshin, Kuzma; Jacobsson, Richard; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jiang, Feng; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Karacson, Matthias; Kariuki, James Mwangi; Karodia, Sarah; Kazeev, Nikita; Kecke, Matthieu; Keizer, Floris; Kelsey, Matthew; Kenzie, Matthew; Ketel, Tjeerd; Khairullin, Egor; Khanji, Basem; Khurewathanakul, Chitsanu; Kim, Kyung Eun; Kirn, Thomas; Klaver, Suzanne; Klimaszewski, Konrad; Klimkovich, Tatsiana; Koliiev, Serhii; Kolpin, Michael; Kopecna, Renata; Koppenburg, Patrick; Kostiuk, Igor; Kotriakhova, Sofia; Kozeiha, Mohamad; Kravchuk, Leonid; Kreps, Michal; Kress, Felix Johannes; Krokovny, Pavel; Krupa, Wojciech; Krzemien, Wojciech; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kvaratskheliya, Tengiz; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lancierini, Davide; Lanfranchi, Gaia; Langenbruch, Christoph; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; Leflat, Alexander; Lefrançois, Jacques; Lefèvre, Regis; Lemaitre, Florian; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Pei-Rong; Li, Tenglin; Li, Zhuoming; Liang, Xixin; Likhomanenko, Tatiana; Lindner, Rolf; Lionetto, Federica; Lisovskyi, Vitalii; Liu, Xuesong; Loh, David; Loi, Angelo; Longstaff, Iain; Lopes, Jose; Lovell, George Holger; Lucchesi, Donatella; Lucio Martinez, Miriam; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Lusiani, Alberto; Lyu, Xiao-Rui; Machefert, Frederic; Maciuc, Florin; Macko, Vladimir; Mackowiak, Patrick; Maddrell-Mander, Samuel; Maev, Oleg; Maguire, Kevin; Maisuzenko, Dmitrii; Majewski, Maciej Witold; Malde, Sneha; Malecki, Bartosz; Malinin, Alexander; Maltsev, Timofei; Manca, Giulia; Mancinelli, Giampiero; Marangotto, Daniele; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marinangeli, Matthieu; Marino, Pietro; Marks, Jörg; Marshall, Phillip John; Martellotti, Giuseppe; Martin, Morgan; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Massafferri, André; Materok, Marcel; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurice, Emilie; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McNab, Andrew; McNulty, Ronan; Mead, James Vincent; Meadows, Brian; Meaux, Cedric; Meier, Frank; Meinert, Nis; Melnychuk, Dmytro; Merk, Marcel; Merli, Andrea; Michielin, Emanuele; Milanes, Diego Alejandro; Millard, Edward James; Minard, Marie-Noelle; Minzoni, Luca; Mitzel, Dominik Stefan; Mogini, Andrea; Molina Rodriguez, Josue; Mombächer, Titus; Monroy, Igancio Alberto; Monteil, Stephane; Morandin, Mauro; Morello, Gianfranco; Morello, Michael Joseph; Morgunova, Olga; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Mulder, Mick; Murphy, Colm Harold; Murray, Donal; Mödden, Antje; Müller, Dominik; Müller, Janine; Müller, Katharina; Müller, Vanessa; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nandi, Anita; Nanut, Tara; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Thi Dung; Nguyen-Mau, Chung; Nieswand, Simon; Niet, Ramon; Nikitin, Nikolay; Nogay, Alla; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Oldeman, Rudolf; Onderwater, Gerco; Ossowska, Anna; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Aranzazu; Pais, Preema Rennee; Pajero, Tommaso; Palano, Antimo; Palutan, Matteo; Panshin, Gennady; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parker, William; Parkes, Christopher; Passaleva, Giovanni; Pastore, Alessandra; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Pereima, Dmitrii; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petrov, Aleksandr; Petrucci, Stefano; Petruzzo, Marco; Pietrzyk, Boleslaw; Pietrzyk, Guillaume; Pikies, Malgorzata; Pili, Martina; Pinci, Davide; Pinzino, Jacopo; Pisani, Flavio; Piucci, Alessio; Placinta, Vlad-Mihai; Playfer, Stephen; Plews, Jonathan; Plo Casasus, Maximo; Polci, Francesco; Poli Lener, Marco; Poluektov, Anton; Polukhina, Natalia; Polyakov, Ivan; Polycarpo, Erica; Pomery, Gabriela Johanna; Ponce, Sebastien; Popov, Alexander; Popov, Dmitry; Poslavskii, Stanislav; Potterat, Cédric; Price, Eugenia; Prisciandaro, Jessica; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Pullen, Hannah Louise; Punzi, Giovanni; Qian, Wenbin; Qin, Jia-Jia; Quagliani, Renato; Quintana, Boris; Rachwal, Bartlomiej; Rademacker, Jonas; Rama, Matteo; Ramos Pernas, Miguel; Rangel, Murilo; Ratnikov, Fedor; Raven, Gerhard; Ravonel Salzgeber, Melody; Reboud, Meril; Redi, Federico; Reichert, Stefanie; dos Reis, Alberto; Reiss, Florian; Remon Alepuz, Clara; Ren, Zan; Renaudin, Victor; Ricciardi, Stefania; Richards, Sophie; Rinnert, Kurt; Robbe, Patrick; Robert, Arnaud; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Roehrken, Markus; Rogozhnikov, Alexey; Roiser, Stefan; Rollings, Alexandra Paige; Romanovskiy, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rudolph, Matthew Scott; Ruf, Thomas; Ruiz Vidal, Joan; Saborido Silva, Juan Jose; Sagidova, Naylya; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Gras, Cristina; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarpis, Gediminas; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saur, Miroslav; Savrina, Darya; Schael, Stefan; Schellenberg, Margarete; Schiller, Manuel; Schindler, Heinrich; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schreiner, HF; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepulveda, Eduardo Enrique; Sergi, Antonino; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seuthe, Alex; Seyfert, Paul; Shapkin, Mikhail; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shmanin, Evgenii; Siddi, Benedetto Gianluca; Silva Coutinho, Rafael; Silva de Oliveira, Luiz Gustavo; Simi, Gabriele; Simone, Saverio; Skidmore, Nicola; Skwarnicki, Tomasz; Smeaton, John Gordon; Smith, Eluned; Smith, Iwan Thomas; Smith, Mark; Soares, Marcelo; Soares Lavra, Lais; Sokoloff, Michael; Soler, Paul; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Stefko, Pavol; Stefkova, Slavomira; Steinkamp, Olaf; Stemmle, Simon; Stenyakin, Oleg; Stepanova, Margarita; Stevens, Holger; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Stramaglia, Maria Elena; Straticiuc, Mihai; Straumann, Ulrich; Strokov, Sergey; Sun, Jiayin; Sun, Liang; Swientek, Krzysztof; Syropoulos, Vasileios; Szumlak, Tomasz; Szymanski, Maciej Pawel; T'Jampens, Stephane; Tang, Zhipeng; Tayduganov, Andrey; Tekampe, Tobias; Tellarini, Giulia; Teubert, Frederic; Thomas, Eric; van Tilburg, Jeroen; Tilley, Matthew James; Tisserand, Vincent; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Tou, Da Yu; Tourinho Jadallah Aoude, Rafael; Tournefier, Edwige; Traill, Murdo; Tran, Minh Tâm; Trisovic, Ana; Tsaregorodtsev, Andrei; Tuci, Giulia; Tully, Alison; Tuning, Niels; Ukleja, Artur; Usachov, Andrii; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagner, Alexander; Vagnoni, Vincenzo; Valassi, Andrea; Valat, Sebastien; Valenti, Giovanni; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vecchi, Stefania; van Veghel, Maarten; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Venkateswaran, Aravindhan; Verlage, Tobias Anton; Vernet, Maxime; Veronesi, Michele; Veronika, Naomi; Vesterinen, Mika; Viana Barbosa, Joao Vitor; Vieira, Daniel; Vieites Diaz, Maria; Viemann, Harald; Vilasis-Cardona, Xavier; Vitkovskiy, Arseniy; Vitti, Marcela; Volkov, Vladimir; Vollhardt, Achim; Voneki, Balazs; Vorobyev, Alexey; Vorobyev, Vitaly; de Vries, Jacco; Vázquez Sierra, Carlos; Waldi, Roland; Walsh, John; Wang, Jianchun; Wang, Mengzhen; Wang, Yilong; Wang, Zhenzi; Ward, David; Wark, Heather Mckenzie; Watson, Nigel; Websdale, David; Weiden, Andreas; Weisser, Constantin; Whitehead, Mark; Wicht, Jean; Wilkinson, Guy; Wilkinson, Michael; Williams, Ifan; Williams, Mark Richard James; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Winn, Michael Andreas; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wyllie, Kenneth; Xiao, Dong; Xie, Yuehong; Xu, Ao; Xu, Menglin; Xu, Qingnian; Xu, Zehua; Xu, Zhirui; Yang, Zhenwei; Yang, Zishuo; Yao, Yuezhe; Yeomans, Lauren Emma; Yin, Hang; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zarebski, Kristian Alexander; Zavertyaev, Mikhail; Zhang, Dongliang; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zheng, Yangheng; Zhu, Xianglei; Zhukov, Valery; Zonneveld, Jennifer Brigitta; Zucchelli, Stefano

    2018-01-01

    The first measurement of the lifetime of the doubly charmed baryon $\\Xi_{cc}^{++}$ is presented, with the signal reconstructed in the final state $\\Lambda_c^+ K^- \\pi^+ \\pi^+$. The data sample used corresponds to an integrated luminosity of $1.7\\,\\mathrm{fb}^{-1}$, collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of $13\\mathrm{\\,Te\\kern -0.1em V}$. The $\\Xi_{cc}^{++}$ lifetime is measured to be $0.256\\,^{+0.024}_{-0.022}{\\,\\rm (stat)\\,} \\pm 0.014 {\\,\\rm(syst)}\\mathrm{\\,ps}$.

  11. Experimental study on thermophysical properties of C/C composites at high temperature

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wei; YI Fa-jun; HAN Jie-cai; MENG Song-he

    2006-01-01

    The coefficient of thermal expansion, thermal diffusivity and specific heat of C/C composites from room temperature to ultra high temperature were experimentally investigated. Thermal conductivity and thermal stress resistance of the composites were therefore computed based on experimental results. The results show that the composite has a very low thermal expansion coefficient. Thermal diffusivity decreases exponentially with temperature increase. The specific heat increases linearly as the temperature rises, and the variation trend of thermal conductivity is similar to that of thermal diffusivity. The thermal stress coefficient of C/C composite has little change with temperature variation, and thermal stress resistance of the composite at high temperature is stable.

  12. Energy Materials Coordinating Committee (EMaCC). Annual Technical Report, Fiscal Year 2000

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2001-07-31

    The Energy Materials Coordinating Committee Annual Report (attached, DOE/SC-0040) provides an annual summary of non-classified materials-related research programs supported by various elements within the Department of Energy. The EMaCC Annual Report is a useful working tool for project managers who want to know what is happening in other divisions, and it provides a guide for persons in industry and academia to the materials program within the Department. The major task of EMaCC this year was to make the Annual Report a more user-friendly document by removing redundant program information and shortening the project summaries.

  13. Provision of relapse prevention interventions in UK NHS Stop Smoking Services: a survey

    Directory of Open Access Journals (Sweden)

    McEwen Andy

    2010-07-01

    Full Text Available Abstract Background UK NHS Stop Smoking Services provide cost effective smoking cessation interventions but, as yet, there has been no assessment of their provision of relapse prevention interventions. Methods Electronic questionnaire survey of 185 UK Stop Smoking Services Managers. Results Ninety six Stop Smoking Service managers returned completed questionnaires (52% response rate. Of these, 58.3% (n = 56 ran NHS Stop Smoking Services which provided relapse prevention interventions for clients with the most commonly provided interventions being behavioural support: telephone (77%, group (73%, and individual (54%. Just under half (48%, n = 27 offered nicotine replacement therapy (NRT, 21.4% (n = 12 bupropion; 19.6% (n = 11 varenicline. Over 80% of those providing relapse prevention interventions do so for over six months. Nearly two thirds of all respondents thought it was likely that they would either continue to provide or commence provision of relapse prevention interventions in their services. Of the remaining respondents, 66.7% (n = 22 believed that the government focus on four-week quit rates, and 42.9% (14 services believed that inadequate funding for provision of relapse prevention interventions, were major barriers to introducing these interventions into routine care. Conclusions Just over half of UK managers of NHS Stop Smoking Services who responded to the questionnaire reported that, in their services, relapse prevention interventions were currently provided for clients, despite, at that time, there being a weak evidence base for their effectiveness. The most commonly provided relapse prevention interventions were those for which there was least evidence. If these interventions are found to be effective, barriers would need to be removed before they would become part of routine care.

  14. Application of frequent itemsets mining to analyze patterns of one-stop visits in Taiwan.

    Directory of Open Access Journals (Sweden)

    Chun-Yi Tu

    Full Text Available BACKGROUND: The free choice of health care facilities without limitations on frequency of visits within the National Health Insurance in Taiwan gives rise to not only a high number of annual ambulatory visits per capita but also a unique "one-stop shopping"phenomenon, which refers to a patient' visits to several specialties of the same healthcare facility in one day. The visits to multiple physicians would increase the potential risk of polypharmacy. The aim of this study was to analyze the frequency and patterns of one-stop visits in Taiwan. METHODOLOGY/PRINCIPAL FINDINGS: The claims datasets of 1 million nationally representative people within Taiwan's National Health Insurance in 2005 were used to calculate the number of patients with one-stop visits. The frequent itemsets mining was applied to compute the combination patterns of specialties in the one-stop visits. Among the total 13,682,469 ambulatory care visits in 2005, one-stop visits occurred 144,132 times and involved 296,822 visits (2.2% of all visits by 66,294 (6.6% persons. People tended to have this behavior with age and the percentage reached 27.5% (5,662 in 20,579 in the age group ≥80 years. In general, women were more likely to have one-stop visits than men (7.2% vs. 6.0%. Internal medicine plus ophthalmology was the most frequent combination with a visited frequency of 3,552 times (2.5%, followed by cardiology plus neurology with 3,183 times (2.2%. The most frequent three-specialty combination, cardiology plus neurology and gastroenterology, occurred only 111 times. CONCLUSIONS/SIGNIFICANCE: Without the novel computational technique, it would be hardly possible to analyze the extremely diverse combination patterns of specialties in one-stop visits. The results of the study could provide useful information either for the hospital manager to set up integrated services or for the policymaker to rebuild the health care system.

  15. Optimal Locations of Bus Stops Connecting Subways near Urban Intersections

    Directory of Open Access Journals (Sweden)

    Yuan Cui

    2015-01-01

    Full Text Available Unsuitable locations of bus stops which provide feeder transportation connecting subways near urban intersections usually lead to the low efficiency of public transport and level of passenger service. A multiobjective optimization model to distribute such stop locations is proposed to attain the shortest total walk distance of passengers and minimum delay time of cars through intersections and travel time of buses. The Pareto frontier and optimal solutions for the proposed model are given by the distance-based and enumerative methods. The Xizhimen bus stop is selected to implement case studies for verifying the validity of the proposed model. The analysis of sensitivity on possible solutions is also carried out in the case studies. The results show that the proposed model is capable of optimizing the locations of bus stops connecting subways near intersections and helpful to improve the level of passengers service and operational efficiency of public transportation.

  16. Observations of NC stop nets for bottlenose dolphin takes

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To observe the NC stop net fishery to document the entanglement of bottlenose dolphins and movement of dolphins around the nets.

  17. Kidney Dialysis: When Is It Time to Stop?

    Science.gov (United States)

    ... is it time to stop? My 82-year-old husband has been on kidney dialysis for a ... of Privacy Practices Notice of Nondiscrimination Manage Cookies Advertising Mayo Clinic is a not-for-profit organization ...

  18. Analysis of movable bus stop boarding and alighting areas.

    Science.gov (United States)

    2013-05-01

    This study explored the feasibility of using movable and reusable boarding and alighting (B&A) pads at bus stops. : Potential design alternatives in terms of materials and structural support for these pads were evaluated. The review : focused on the ...

  19. Higgs-Stoponium Mixing Near the Stop-Antistop Threshold

    CERN Document Server

    Bodwin, Geoffrey T; Wagner, Carlos E M

    2016-01-01

    Supersymmetric extensions of the standard model contain additional heavy neutral Higgs bosons that are coupled to heavy scalar top quarks (stops). This system exhibits interesting field theoretic phenomena when the Higgs mass is close to the stop-antistop production threshold. Existing work in the literature has examined the digluon-to-diphoton cross section near threshold and has focused on enhancements in the cross section that might arise either from the perturbative contributions to the Higgs-to-digluon and Higgs-to-diphoton form factors or from mixing of the Higgs boson with stoponium states. Near threshold, enhancements in the relevant amplitudes that go as inverse powers of the stop-antistop relative velocity require resummations of perturbation theory and/or nonperturbative treatments. We present a complete formulation of threshold effects at leading order in the stop-antistop relative velocity in terms of nonrelativistic effective field theory. We give detailed numerical calculations for the case in ...

  20. Density dependence of stopping cross sections measured in liquid ethane

    International Nuclear Information System (INIS)

    Both, G.; Krotz, R.; Lohmer, K.; Neuwirth, W.

    1983-01-01

    Electronic stopping cross sections for 7 Li projectiles (840--175 keV) have been measured with the inverted Doppler-shift attenuation method in liquid ethane (C 2 H 6 ) at two different densities. The density of the target has been varied by changing the temperature, and measurements have been performed at 0.525 g/cm 3 (199 K) and 0.362 g/cm 3 (287 K). At the higher density the stopping cross section is about 2% smaller. This result agrees with a calculation of the stopping cross section of liquid ethane, applying Lindhard's theory in the local-density approximation using a simple model of the liquid. It is also in agreement with various observations of the so-called physical-state effect, which show that the stopping cross section of the same substance is smaller in a condensed phase than in the gaseous one

  1. We Can Stop HIV One Conversation at a Time

    Centers for Disease Control (CDC) Podcasts

    As part of the We Can Stop HIV One Conversation at a Time campaign, this 30 second PSA encourages Hispanics/Latinos to talk openly about HIV and AIDS with their families, friends, partners, and communities.

  2. Stopping the Spread of Germs at Home, Work and School

    Science.gov (United States)

    ... Pandemic Other Stopping the Spread of Germs at Home, Work & School Language: English (US) Español Recommend on Facebook ... everyone from getting germs or spreading germs at home, work, or school. Clean and disinfect surfaces or objects. ...

  3. Vaccines Stop Illness | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Diseases and Vaccinations Vaccines Stop Illness Past Issues / Spring 2015 Table of ... like polio and meningitis will affect their children. Vaccine Safety In light of recent questions about vaccine ...

  4. Mechanical stop mechanism for overcoming MEMS fabrication tolerances

    International Nuclear Information System (INIS)

    Hussein, Hussein; Bourbon, Gilles; Le Moal, Patrice; Lutz, Philippe; Haddab, Yassine

    2017-01-01

    A mechanical stop mechanism is developed in order to compensate MEMS fabrication tolerances in discrete positioning. The mechanical stop mechanism is designed to be implemented on SOI wafers using a common DRIE etching process. The various fabrication tolerances obtained due to the etching process are presented and discussed in the paper. The principle and design of the mechanism are then presented. Finally, experiments on microfabricated positioning prototypes show accurate steps unaffected by the fabrication tolerances. (technical note)

  5. Station Stopping of Freight Trains with Pneumatic Braking

    OpenAIRE

    Yun Bai; Baohua Mao; Tinkin Ho; Yu Feng; Shaokuan Chen

    2014-01-01

    In Chinese mainline railway, freight trains need to stop within passenger stations at times because of the delayed passenger trains. Without any decision-support system, it is very difficult for drivers to stop trains within stations with consistency in one braking action. The reasons are that braking performance of train changes with the conditions of braking equipment and the drivers’ subjective evaluations of track profiles and braking distance are vague and imprecise. This paper presents ...

  6. Stopping power of K electrons at extreme relativistic energies

    International Nuclear Information System (INIS)

    Leung, P.T.; Rustgi, M.L.

    1983-01-01

    The recent work of Anholt on K-vacancy production by relativistic projectiles has been applied to calculate the stopping power of the K electrons. The results show that for protons of energy approx.10 3 GeV and heavy target elements, the relativistic contributions to the stopping power amount to several times the resuls due to the longitudinal terms obtained from Walske's work

  7. Motor Preparation Disrupts Proactive Control in the Stop Signal Task

    Directory of Open Access Journals (Sweden)

    Wuyi Wang

    2018-05-01

    Full Text Available In a study of the stop signal task (SST we employed Bayesian modeling to compute the estimated likelihood of stop signal or P(Stop trial by trial and identified regional processes of conflict anticipation and response slowing. A higher P(Stop is associated with prolonged go trial reaction time (goRT—a form of sequential effect—and reflects proactive control of motor response. However, some individuals do not demonstrate a sequential effect despite similar go and stop success (SS rates. We posited that motor preparation may disrupt proactive control more in certain individuals than others. Specifically, the time interval between trial and go signal onset—the fore-period (FP—varies across trials and a longer FP is associated with a higher level of motor preparation and shorter goRT. Greater motor preparatory activities may disrupt proactive control. To test this hypothesis, we compared brain activations and Granger causal connectivities of 81 adults who demonstrated a sequential effect (SEQ and 35 who did not (nSEQ. SEQ and nSEQ did not differ in regional activations to conflict anticipation, motor preparation, goRT slowing or goRT speeding. In contrast, SEQ and nSEQ demonstrated different patterns of Granger causal connectivities. P(Stop and FP activations shared reciprocal influence in SEQ but FP activities Granger caused P(Stop activities unidirectionally in nSEQ, and FP activities Granger caused goRT speeding activities in nSEQ but not SEQ. These findings support the hypothesis that motor preparation disrupts proactive control in nSEQ and provide direct neural evidence for interactive go and stop processes.

  8. Stopping power of degenerate electron liquid at metallic densities

    International Nuclear Information System (INIS)

    Tanaka, Shigenori; Ichimaru, Setsuo

    1985-01-01

    We calculate the stopping power of the degenerate electron liquid at metallic densities in the dielectric formalism. The strong Coulomb-coupling effects beyond the random-phase approximation are taken into account through the static and dynamic local-field corrections. It is shown that those strong-coupling and dynamic effects act to enhance the stopping power substantially in the low-velocity regime, leading to an improved agreement with experimental data. (author)

  9. Unsure When to Stop? Ask Your Semantic Neighbors

    OpenAIRE

    Gonçalves, Ivo; Silva, Sara; Fonseca, Carlos M.; Castelli, Mauro

    2017-01-01

    In iterative supervised learning algorithms it is common to reach a point in the search where no further induction seems to be possible with the available data. If the search is continued beyond this point, the risk of overfitting increases significantly. Following the recent developments in inductive semantic stochastic methods, this paper studies the feasibility of using information gathered from the semantic neighborhood to decide when to stop the search. Two semantic stopping criteria are...

  10. Good news is bad news: Leverage cycles and sudden stops

    OpenAIRE

    Akinci, Ozge; Chahrour, Ryan

    2015-01-01

    We show that a model with imperfectly forecastable changes in future productivity and an occasionally binding collateral constraint can match a set of stylized facts about “sudden stop” events. “Good” news about future productivity raises leverage during times of expansion, increasing the probability that the constraint binds, and a sudden stop occurs, in future periods. The economy exhibits a boom period in the run-up to the sudden stop, with output, consumption, and investment all above tre...

  11. Modeling Stop-and-Go Waves in Pedestrian Dynamics

    OpenAIRE

    Portz, Andrea; Seyfried, Armin

    2010-01-01

    Several spatially continuous pedestrian dynamics models have been validated against empirical data. We try to reproduce the experimental fundamental diagram (velocity versus density) with simulations. In addition to this quantitative criterion, we tried to reproduce stop-and-go waves as a qualitative criterion. Stop-and-go waves are a characteristic phenomenon for the single file movement. Only one of three investigated models satisfies both criteria.

  12. Stop Think: a simple approach to encourage the self-assessment of learning.

    Science.gov (United States)

    Guy, Richard; Byrne, Bruce; Dobos, Marian

    2017-03-01

    A simple "stop think" approach was developed to encourage the self-assessment of learning. A key element was the requirement for students to rate their feeling of difficulty before [FOD (pre) ] and after [FOD (post) ] completing each of three authentic anatomy and physiology concept map exercises. The cohort was divided into low- (group L) and high-performing (group H) groups (based on final subject marks). Both FOD (pre) (group L) and FOD (post) (groups L and H) were significantly negatively correlated with score for some maps. A comparison of FOD (pre) and FOD (post) showed that students changed their mind about difficulty in 58-70% of the completed maps. Students who changed their estimation were asked to provide explanatory comments, and an increase in difficulty was related to problems with map link generation. For students who found the maps easier, 40% of comments indicated that map generation prompted recall of information from memory. Both difficulty estimations and comments supported the contention that students were self-assessing their interaction with the concept maps. Group H was significantly older than group L, had significantly higher levels of deep strategic and deep motivational learning, and had significantly higher marks in two of three concept map exercises. Notwithstanding these differences, the results from the "stop think" approach were similar between groups, indicating that it may be appropriate for students of varying academic ability. It is suggested that "stop think" may be a useful approach to encourage student self-assessment, an important step in assisting self-regulated learning development. Copyright © 2017 the American Physiological Society.

  13. Response inhibition deficits in externalizing child psychiatric disorders: An ERP-study with the Stop-task

    Directory of Open Access Journals (Sweden)

    Heinrich Hartmut

    2005-12-01

    Full Text Available Abstract Background Evidence from behavioural studies suggests that impaired motor response inhibition may be common to several externalizing child psychiatric disorders, although it has been proposed to be the core-deficit in AD/HD. Since similar overt behaviour may be accompanied by different covert brain activity, the aim of this study was to investigate both brain-electric-activity and performance measures in three groups of children with externalizing child psychiatric disorders and a group of normal controls. Methods A Stop-task was used to measure specific aspects of response inhibition in 10 children with attention-deficit hyperactivity disorder (AD/HD, 8 children with oppositional defiant disorder/conduct disorder (ODD/CD, 11 children with comorbid AD/HD+ODD/CD and 11 normal controls. All children were between 8 and 14 years old. Event-related potentials and behavioural responses were recorded. An initial go-signal related microstate, a subsequent Stop-signal related N200, and performance measures were analyzed using ANCOVA with age as covariate. Results Groups did not differ in accuracy or reaction time to the Go-stimuli. However, all clinical groups displayed reduced map strength in a microstate related to initial processing of the Go-stimulus compared to normal controls, whereas topography did not differ. Concerning motor response inhibition, the AD/HD-only and the ODD/CD-only groups displayed slower Stop-signal reaction times (SSRT and Stop-failure reaction time compared to normal controls. In children with comorbid AD/HD+ODD/CD, Stop-failure reaction-time was longer than in controls, but their SSRT was not slowed. Moreover, SSRT in AD/HD+ODD/CD was faster than in AD/HD-only or ODD/CD-only. The AD/HD-only and ODD/CD-only groups displayed reduced Stop-N200 mean amplitude over right-frontal electrodes. This effect reached only a trend for comorbid AD/HD+ODD/CD. Conclusion Following similar attenuations in initial processing of the Go

  14. Automation of ETE-CC 2/3 (Effluent Treatment Station); Automacao da ETE-CC 2/3 (Estacao de Tratamento de Efluentes)

    Energy Technology Data Exchange (ETDEWEB)

    Sinzato, Frederico Takashi Di Tanno; Esteves, Joao Paulo Leite; Souza, Rafael Soares de; Gomes, Lucio Nascimento; Santos, Leonardo Paiva [Companhia Siderurgica Nacional (CSN), Volta Redonda, RJ (Brazil)

    2009-11-01

    The present technical contribution presents the results of the implantation of a complete automation system of the ETE-CC 2/3 (Effluent Treatment Station of Continuous Casting Machine 2 and 3 of CSN), improving the reliability and the operation mode of the plant. The implanted system has the following features: remote operation and remote monitoring of all equipment of station; redundancy of operation stations, PLC's, communication networks and UPS; possibility of local control of equipment without automation system; wireless system of control and monitoring for the filters; recording system for all process variables. (author)

  15. Characterization of C/C composites porosity for the fusion; Caracterisation de la porosite de composites C/C d'interet pour la fusion

    Energy Technology Data Exchange (ETDEWEB)

    Martin, C.; Ballet, A.C.; Pardanaud, C.; Roubin, P. [Universite de Provence, Centre St-Jerome, Laboratoire PIIM, 13 - Marseille (France); Beurroies, I.; Richou, M. [Universite de Provence, Centre St-Jerome, Laboratoire Madirel, 13 - Marseille (France); Brosset, C.; Pegourie, B. [Association EURATOM-CEA sur la Fusion Controlee, CE Cadarache, 13 - St-Paul-lez-Durance (France)

    2008-07-01

    In tokamaks, the composites C/C are used as components facing the plasma because of their excellent thermo-mechanical properties. In Tore Supra tokamak, analysis of particles of graphite erosion showed a big deuterium retention by the machine wall. This fuel retention will lead in ITER to a non acceptable level of tritium. As the diffusion in materials is bound to the porosity, the authors realized a study of two composites porosity: N11 and NB31. Different analysis methods have been performed and the temperature or grain size dependence studied. (A.L.B.)

  16. Bacillus velezensis CC09: A Potential 'Vaccine' for Controlling Wheat Diseases.

    Science.gov (United States)

    Kang, Xingxing; Zhang, Wanling; Cai, Xunchao; Zhu, Tong; Xue, Yarong; Liu, Changhong

    2018-04-11

    Biocontrol bacteria that can act like a "vaccine", stimulating plant resistance to pathogenic diseases, are still not fully elucidated. In this study, an endophytic bacterium, Bacillus velezensis CC09, labeled with green fluorescent protein, was tested for its colonization, migration, and expression of genes encoding iturin A synthetase within wheat tissues and organs as well as for protective effects against wheat take-all and spot blotch diseases. The results showed that strain CC09 not only formed biofilm on the root surface but was also widely distributed in almost every tissue, including the epidermis, cortex, and xylem vessels, and even migrated to stems and leaves, resulting in 66.67% disease-control efficacy (DCE) of take-all and 21.64% DCE of spot blotch. Moreover, the gene cluster encoding iturin A synthase under the control of the p itu promoter is expressed in B. velezensis CC09 in wheat tissues, which indicates that iturin A might contribute to the in-vivo antifungal activity and leads to the disease control. All these data suggested that strain CC09 can act like a 'vaccine' in the control of wheat diseases, with a single treatment inoculated on roots through multiple mechanisms.

  17. High temperature oxidation behaviour of mullite coated C/C composites in air

    International Nuclear Information System (INIS)

    Fritze, H.; Borchardt, G.; Weber, S.; Scherrer, S.; Weiss, R.

    1997-01-01

    Based on thermogravimetric measurements on Si-SiC-mullite coated C/C material the temperature dependence of the overall rate constant is interpreted in the temperature range 400 C 1400 C), however, the oxidation behaviour of SiC limits long term application. In this temperature range, additional outer mullite coatings produced by pulsed laser deposition improve the oxidation behaviour. (orig.)

  18. Selective C--C coupling of ir-ethene and ir-carbenoid radicals

    NARCIS (Netherlands)

    Dzik, W.I.; Reek, J.N.H.; de Bruin, B.

    2008-01-01

    The reactivity of the paramagnetic iridium(II) complex [IrII(ethene)(Me3tpa)]2+ (1) (Me3tpa=N,N,N-tris(6-methyl-2-pyridylmethyl) amine) towards the diazo compounds ethyl diazoacetate (EDA) and trimethylsilyldiazomethane (TMSDM) was investigated. The reaction with EDA gave rise to selective CC bond

  19. The cc-bar and bb-bar spectroscopy in the two-step potential model

    International Nuclear Information System (INIS)

    Kulshreshtha, D.S.; Kaiserslautern Univ.

    1984-07-01

    We investigate the spectroscopy of the charmonium (cc-bar) and bottonium (bb-bar) bound states in a static flavour independent nonrelativistic quark-antiquark (qq-bar) two-step potential model proposed earlier. Our predictions are in good agreement with experimental data and with other theoretical predictions. (author)

  20. A 50 cc Two-Stroke DI Compression Ignition Engine Fuelled by DME

    DEFF Research Database (Denmark)

    Hansen, Kim Rene; Nielsen, Claus Suldrup; Sorenson, Spencer C

    2008-01-01

    efficiency to even the smallest engines. A 50cc crankcase scavenged two-stroke CI engine was built based on moped parts. The major alterations were a new cylinder head and a 100 bar DI system using a GDItype injector. Power is limited by carbon monoxide emission but smoke-free operation and NOx less than 200...

  1. Is puberty an accelerator of type 1 diabetes in IL6-174CC females?

    DEFF Research Database (Denmark)

    Gillespie, Kathleen M; Nolsøe, Runa; Betin, Virginie M

    2005-01-01

    but not in males. We found that the IL6-174CC genotype was significantly less frequent in females diagnosed after than in those diagnosed before the age of 10 years (19 vs. 13%, P = 0.016). No genotype difference was observed in males stratified for age at onset. Among children diagnosed after age 10, the median...

  2. Students' Learning with the Connected Chemistry (CC1) Curriculum: Navigating the Complexities of the Particulate World

    Science.gov (United States)

    Levy, Sharona T.; Wilensky, Uri

    2009-01-01

    The focus of this study is students' learning with a Connected Chemistry unit, CC1 (denotes Connected Chemistry, chapter 1), a computer-based environment for learning the topics of gas laws and kinetic molecular theory in chemistry (Levy and Wilensky 2009). An investigation was conducted into high-school students' learning with Connected…

  3. Immune response CC Chemokines, CCL2 and CCL5 are associated with Pulmonary Sarcoidosis

    LENUS (Irish Health Repository)

    Palchevskiy, Vyacheslav

    2011-04-04

    Abstract Background Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors. Previous studies have demonstrated conflicting results with regard to the associations of these chemokines with sarcoidosis. In an effort to clarify previous discrepancies, we performed the largest observational study to date of CC chemokines in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis. Results BALF chemokine levels from 72 patients affected by pulmonary sarcoidosis were analyzed by enzyme-linked immunosorbent assay (ELISA) and compared to 8 healthy volunteers. BALF CCL3 and CCL4 levels from pulmonary sarcoidosis patients were not increased compared to controls. However, CCL2 and CCL5 levels were elevated, and subgroup analysis showed higher levels of both chemokines in all stages of pulmonary sarcoidosis. CCL2, CCL5, CC chemokine receptor type 1 (CCR1), CCR2 and CCR3 were expressed from mononuclear cells forming the lung granulomas, while CCR5 was only found on mast cells. Conclusions These data suggest that CCL2 and CCL5 are important mediators in recruiting CCR1, CCR2, and CCR3 expressing mononuclear cells as well as CCR5-expressing mast cells during all stages of pulmonary sarcoidosis.

  4. Development of a Class for Multiple Precision Arithmetic in C/C++ Language

    OpenAIRE

    福田, 宏

    1998-01-01

    We have defined a floating-point variable of arbitrary length for a calculation of high precision and have developed a set of mathematical functions of it in C/C++ language. The variable and the functions are combined into a class in C++ language. In addition, the functions can be easily converted to those in FORTRAN language.

  5. MemPick : High-level data structure detection in C/C++ binaries

    NARCIS (Netherlands)

    Haller, Istvan; Slowinska, Asia; Bos, Herbert

    2013-01-01

    Many existing techniques for reversing data structures in C/C++ binaries are limited to low-level programming constructs, such as individual variables or structs. Unfortunately, without detailed information about a program's pointer structures, forensics and reverse engineering are exceedingly hard.

  6. Scalable data structure detection and classification for C/C++ binaries

    NARCIS (Netherlands)

    Haller, I.; Slowinska, J.M.; Bos, H.J.

    2015-01-01

    Many existing techniques for reversing data structures in C/C ++ binaries are limited to low-level programming constructs, such as individual variables or structs. Unfortunately, without detailed information about a program's pointer structures, forensics and reverse engineering are exceedingly

  7. Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis.

    Science.gov (United States)

    Palchevskiy, Vyacheslav; Hashemi, Nastran; Weigt, Stephen S; Xue, Ying Ying; Derhovanessian, Ariss; Keane, Michael P; Strieter, Robert M; Fishbein, Michael C; Deng, Jane C; Lynch, Joseph P; Elashoff, Robert; Belperio, John A

    2011-04-04

    Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors. Previous studies have demonstrated conflicting results with regard to the associations of these chemokines with sarcoidosis. In an effort to clarify previous discrepancies, we performed the largest observational study to date of CC chemokines in bronchoalveolar lavage fluid (BALF) from patients with pulmonary sarcoidosis. BALF chemokine levels from 72 patients affected by pulmonary sarcoidosis were analyzed by enzyme-linked immunosorbent assay (ELISA) and compared to 8 healthy volunteers. BALF CCL3 and CCL4 levels from pulmonary sarcoidosis patients were not increased compared to controls. However, CCL2 and CCL5 levels were elevated, and subgroup analysis showed higher levels of both chemokines in all stages of pulmonary sarcoidosis. CCL2, CCL5, CC chemokine receptor type 1 (CCR1), CCR2 and CCR3 were expressed from mononuclear cells forming the lung granulomas, while CCR5 was only found on mast cells. These data suggest that CCL2 and CCL5 are important mediators in recruiting CCR1, CCR2, and CCR3 expressing mononuclear cells as well as CCR5-expressing mast cells during all stages of pulmonary sarcoidosis.

  8. Unilateral Versus Bilateral Laparoscopic Ovarian Drilling Using Thermal Dose Adjusted According to Ovarian Volume in CC-Resistant PCOS, A Randomized Study.

    Science.gov (United States)

    El-Sayed, Mohamed Lotfy Mohamed; Ahmed, Mostafa Abdo; Mansour, Marwa Abdel Azim; Mansour, Shymma Abdel Azim

    2017-10-01

    This study aimed to evaluate the efficacy of unilateral laparoscopic ovarian drilling versus bilateral laparoscopic ovarian drilling with thermal dose adjusted according to ovarian volume in clomiphene citrate (CC)-resistant PCOS patients in terms of endocrine changes, menstrual cycle resumption, ovulation and pregnancy rates. This study was conducted in the Department of Obstetrics and Gynecology, Zagazig university hospitals. One hundred CC-resistant PCOS patients were divided into two groups. Group (I) (50 patients) underwent unilateral laparoscopic ovarian drilling with thermal dose adjusted according to ovarian volume (60 J/cm 3 of ovarian tissue), and group (II) (50 patients) underwent bilateral laparoscopic ovarian drilling using the same previously mentioned thermal dose. Endocrinal changes and menstrual cycle resumption were assessed within 8 weeks postoperatively, but the ovulation and pregnancy rates were estimated after 6-month follow-up period. There was no statistically significant difference between the two groups as regards demographic data ( p  > 0.05). As regards menstruation cycle resumption (62.5 vs. 81%) ( p  = 0.047), total ovulation rate (54.2 vs. 78.7%) ( p  = 0.011) and cumulative pregnancy rate (33.3 vs. 55.3%) ( p  = 0.031), there was statistically significant difference between both groups. After drilling, there were highly statistically significant decrease in the mean serum levels of luteinizing hormone (LH) and significant decrease in the mean serum levels of testosterone in both groups. Mean serum level of follicle stimulating hormone (FSH) did not change significantly in both groups after drilling. Bilateral laparoscopic ovarian drilling with thermal dose adjusted according to ovarian volume is more effective than the right-sided unilateral technique with thermal dose adjusted according to ovarian volume in terms of menstrual cycle resumption, ovulation and cumulative pregnancy rates in CC-resistant PCOS patients.

  9. Molecular and functional roles of 6C CC chemokine 19 in defense system of striped murrel Channa striatus.

    Science.gov (United States)

    Arockiaraj, Jesu; Bhatt, Prasanth; Harikrishnan, Ramasamy; Arasu, Mariadhas Valan; Al-Dhabi, Naif Abdullah

    2015-08-01

    In this study, we have reported the molecular information of chemokine-19 (Chem19) from striped murrel Channa striatus (Cs). CsCC-Chem19 cDNA sequence was 555 base pair (bp) in length which is 68bp 5' untranslated region (UTR), 339bp translated region and 149bp 3' UTR. The translated region is encoded for a polypeptide of 112 amino acids. CsCC-Chem19 peptide contains a signal sequence between 1 and 26 and an interleukin (IL) 8 like domain between 24 and 89. The multiple sequence alignment showed a 'DCCL' motif, an indispensable motif present in all CC chemokines which was conserved throughout the evolution. Phylogenetic tree showed that CsCC-Chem19 formed a cluster with chemokine 19 from fishes. Secondary structure of CsCC-Chem19 revealed that the peptide contains maximum amount of coils (61.6%) compared to α-helices (25.9%%) and β-sheet (12.5%). Further, 3D analysis indicated that the cysteine residues at 33, 34, 59 and 75 making the disulfide bridges as 33 = 59 and 34 = 75. Significantly (P coding region of CsCC-Chem19, recombinant CsCC-Chem19 protein was produced. The recombinant CsCC-Chem19 protein induced the cellular proliferation and respiratory burst activity of C. striatus peripheral blood leukocytes (PBL) in a concentration dependent manner. Moreover, the chemotactic activity showed that the recombinant CsCC-Chem19 significantly (P < 0.05) enhanced the movement of PBL of C. striatus. Conclusively, CsCC-Chem19 is a 6C CC chemokine having an ability to perform both inflammatory and homeostatic functions. However, further research is necessary to understand the potential of 6C CC chemokine 19 of C. striatus, particularly their regulatory ability on different cellular components in the defense system. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2002

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2003-08-08

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCC Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed. The EMaCC Charter and the memorandum approving it are presented in the Appendix of this report. The FY 2002 budget summary for DOE Materials Activities is presented on page 8. The distribution of these funds between DOE laboratories, private industry, academia and other organizations is presented in tabular form on page 10. Following the budget summary is a set of detailed program descriptions for the FY 2002 DOE Materials activities. These descriptions are presented according to the organizational structure of the Department. A mission statement, a budget summary listing the project titles and FY 2002 funding, and detailed project summaries are presented for each Assistant Secretary office, the Office of Science, and the National Nuclear Security Administration. The project summaries also provide DOE, laboratory, academic and industrial contacts for each project, as appropriate.

  11. A pair natural orbital implementation of the coupled cluster model CC2 for excitation energies.

    Science.gov (United States)

    Helmich, Benjamin; Hättig, Christof

    2013-08-28

    We demonstrate how to extend the pair natural orbital (PNO) methodology for excited states, presented in a previous work for the perturbative doubles correction to configuration interaction singles (CIS(D)), to iterative coupled cluster methods such as the approximate singles and doubles model CC2. The original O(N(5)) scaling of the PNO construction is reduced by using orbital-specific virtuals (OSVs) as an intermediate step without spoiling the initial accuracy of the PNO method. Furthermore, a slower error convergence for charge-transfer states is analyzed and resolved by a numerical Laplace transformation during the PNO construction, so that an equally accurate treatment of local and charge-transfer excitations is achieved. With state-specific truncated PNO expansions, the eigenvalue problem is solved by combining the Davidson algorithm with deflation to project out roots that have already been determined and an automated refresh with a generation of new PNOs to achieve self-consistency of the PNO space. For a large test set, we found that truncation errors for PNO-CC2 excitation energies are only slightly larger than for PNO-CIS(D). The computational efficiency of PNO-CC2 is demonstrated for a large organic dye, where a reduction of the doubles space by a factor of more than 1000 is obtained compared to the canonical calculation. A compression of the doubles space by a factor 30 is achieved by a unified OSV space only. Moreover, calculations with the still preliminary PNO-CC2 implementation on a series of glycine oligomers revealed an early break even point with a canonical RI-CC2 implementation between 100 and 300 basis functions.

  12. The frequentist implications of optional stopping on Bayesian hypothesis tests.

    Science.gov (United States)

    Sanborn, Adam N; Hills, Thomas T

    2014-04-01

    Null hypothesis significance testing (NHST) is the most commonly used statistical methodology in psychology. The probability of achieving a value as extreme or more extreme than the statistic obtained from the data is evaluated, and if it is low enough, the null hypothesis is rejected. However, because common experimental practice often clashes with the assumptions underlying NHST, these calculated probabilities are often incorrect. Most commonly, experimenters use tests that assume that sample sizes are fixed in advance of data collection but then use the data to determine when to stop; in the limit, experimenters can use data monitoring to guarantee that the null hypothesis will be rejected. Bayesian hypothesis testing (BHT) provides a solution to these ills because the stopping rule used is irrelevant to the calculation of a Bayes factor. In addition, there are strong mathematical guarantees on the frequentist properties of BHT that are comforting for researchers concerned that stopping rules could influence the Bayes factors produced. Here, we show that these guaranteed bounds have limited scope and often do not apply in psychological research. Specifically, we quantitatively demonstrate the impact of optional stopping on the resulting Bayes factors in two common situations: (1) when the truth is a combination of the hypotheses, such as in a heterogeneous population, and (2) when a hypothesis is composite-taking multiple parameter values-such as the alternative hypothesis in a t-test. We found that, for these situations, while the Bayesian interpretation remains correct regardless of the stopping rule used, the choice of stopping rule can, in some situations, greatly increase the chance of experimenters finding evidence in the direction they desire. We suggest ways to control these frequentist implications of stopping rules on BHT.

  13. The prevalence of mental health problems among users of NHS stop smoking services: effects of implementing a routine screening procedure

    Directory of Open Access Journals (Sweden)

    Ratschen Elena

    2011-08-01

    Full Text Available Abstract Background Tobacco dependence among people with mental health problems is an issue that deserves attention both from a clinical and from a public health perspective. Research suggests that Stop Smoking Services often fail to ask clients about underlying mental health problems and thus fail to put in place the treatment adaptations and liaison procedures often required to meet the needs of clients with a mental health condition who want to stop smoking. This study assesses the recording of mental health problems in a large NHS stop smoking service in England and examines the effect of implementing a short screening procedure on recording mental health conditions. Methods Treatment records from the Stop Smoking Service covering a period of 13 months were audited. The prevalence of reported mental health problems in the six month period before the implementation of the mental health screening procedure was compared with that of the six month period following implementation. The screening procedure was only implemented in the support services directly provided by the Stop Smoking Service. Comparisons were also made with third-party sections of the service where no such screening procedure was introduced. Results The prevalence of reported mental health problems among a total of n = 4999 clients rose from less than 1% before implementation of the screening procedure to nearly 12% in the period following implementation, with the change being statistically significant. No significant rise was observed over the same period in the sections of the service where no screening procedure was implemented. Conclusions The absence of standard procedures to record mental health problems among service users in many stop smoking services is currently likely to prevent the detection of co morbidity. Implementing a simple screening procedure appears suitable to increase the routine recording of mental health problems in a stop smoking service, which is an

  14. Student Services/One Stop Centers: A Qualitative Examination of Implementation at Three Post-Secondary Institutions

    Science.gov (United States)

    Becker, Janine M.

    2012-01-01

    This research investigates Student Services/One Stop Centers at three post-secondary institutions, looking at the origination of the centers and success through the lens of behavioral theories. Comparing the 3-stage Group Dynamics Theory of Lewin (1947), Social Learning Theory of Bandura (1977), and the 8-stage Change Management Model of Kotter…

  15. Stop nuclear testing as soon as possible

    International Nuclear Information System (INIS)

    Meerburg, A.J.

    1975-01-01

    The article is the text of a speech presented by the Netherlands' delegate to the 1975 Conference of the Committee on Disarmament. The delegate endorses a proposal to study the possibilities of a reduction in military budgets via a comparative evaluation of the budgets of several states. Reduction of national budgets might serve as a safeguard. An expert group was instituted by CCD to realize this proposal. Further, a ban on peaceful nuclear explosions with perhaps a few internationally-licensed exceptions is advocated

  16. Exploring the nearly degenerate stop region with sbottom decays

    Energy Technology Data Exchange (ETDEWEB)

    An, Haipeng [Walter Burke Institute for Theoretical Physics, California Institute of Technology,1200 E. California Blvd, Pasadena, CA, 91125 (United States); Gu, Jiayin [Center for Future High Energy Physics, Institute of High Energy Physics,19B YuquanLu, Chinese Academy of Sciences, Beijing, 100049 (China); DESY,Notkestraße 85, Hamburg, D-22607 (Germany); Wang, Lian-Tao [Enrico Fermi Institute, University of Chicago,5640 S Ellis Ave., Chicago, IL, 60637 (United States); Kavli Institute for Cosmological Physics, University of Chicago,5640 S Ellis Ave., Chicago, IL, 60637 (United States)

    2017-04-13

    A light stop with mass almost degenerate with the lightest neutralino has important connections with both naturalness and dark matter relic abundance. This region is also very hard to probe at colliders. In this paper, we demonstrate the potential of searching for such stop particles at the LHC from sbottom decays, focusing on two channels with final states 2ℓ+E{sub T}{sup miss} and 1b1ℓ+E{sub T}{sup miss}. We found that, if the lightest sbottom has mass around or below 1 TeV and has a significant branching ratio to decay to stop and W (b̃→t̃ W), a stop almost degenerate with neutralino can be excluded up to about 500–600 GeV at the 13 TeV LHC with 300 fb{sup −1} data. The searches we propose are complementary to other SUSY searches at the LHC and could have the best sensitivity to the stop-bino coannihilation region. Since they involve final states which have already been used in LHC searches, a reinterpretation of the search results already has sensitivity. Further optimization could deliver the full potential of these channels.

  17. Exploring the nearly degenerate stop region with sbottom decays

    Energy Technology Data Exchange (ETDEWEB)

    An, Haipeng [California Institute of Technology, Pasadena, CA (United States). Walter Burke Inst. for Theoretical Physics; Gu, Jiayin [Chinese Academy of Sciences, Beijing (China). Inst. of High Energy Physics; Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Wang, Lian-Tao [Chicago Univ., IL (United States). Enrico Fermi Inst.; Chicago Univ., IL (United States). Kavli Inst. for Cosmological Physics

    2016-11-15

    A light stop with mass almost degenerate with the lightest neutralino has important connections with both naturalness and dark matter relic abundance. This region is also very hard to probe at colliders. In this paper, we demonstrate the potential of searching for such stop particles at the LHC from sbottom decays, focusing on two channels with final states 2l+E{sup miss}{sub T} and 1b1l+E{sup miss}{sub T}. We found that, if the lightest sbottom has mass around or below 1 TeV and has a significant branching ratio to decay to stop and W (b→tW), a stop almost degenerate with neutralino can be excluded up to about 500-600 GeV at the 13 TeV LHC with 300 fb{sup -1} data. The searches we propose are complementary to other SUSY searches at the LHC and could have the best sensitivity to the stop-bino coannihilation region. Since they involve final states which have already been used in LHC searches, a reinterpretation of the search results already has sensitivity. Further optimization could deliver the full potential of these channels.

  18. Stopping time of a one-dimensional bounded quantum walk

    International Nuclear Information System (INIS)

    Luo Hao; Zhang Peng; Zhan Xiang; Xue Peng

    2016-01-01

    The stopping time of a one-dimensional bounded classical random walk (RW) is defined as the number of steps taken by a random walker to arrive at a fixed boundary for the first time. A quantum walk (QW) is a non-trivial generalization of RW, and has attracted a great deal of interest from researchers working in quantum physics and quantum information. In this paper, we develop a method to calculate the stopping time for a one-dimensional QW. Using our method, we further compare the properties of stopping time for QW and RW. We find that the mean value of the stopping time is the same for both of these problems. However, for short times, the probability for a walker performing a QW to arrive at the boundary is larger than that for a RW. This means that, although the mean stopping time of a quantum and classical walker are the same, the quantum walker has a greater probability of arriving at the boundary earlier than the classical walker. (paper)

  19. Reciprocity in the electronic stopping of slow ions in matter

    International Nuclear Information System (INIS)

    Sigmund, P.

    2008-01-01

    The principle of reciprocity, i.e., the invariance of the inelastic excitation in ion-atom collisions against interchange of projectile and target, has been applied to the electronic stopping cross section of low-velocity ions and tested empirically on ion-target combinations supported by a more or less adequate amount of experimental data. Reciprocity is well obeyed (within ∼10%) for many systems studied, and deviations exceeding ∼20% are exceptional. Systematic deviations such as gas-solid or metal-insulator differences have been looked for but not identified on the present basis. A direct consequence of reciprocity is the equivalence of Z 1 with Z 2 structure for random slowing down. This feature is reasonably well supported empirically for ion-target combinations involving carbon, nitrogen, aluminium and argon. Reciprocity may be utilized as a criterion to reject questionable experimental data. In cases where a certain stopping cross section has not been or cannot be measured, the stopping cross section for the inverted system may be available and serve as a first estimate. It is suggested to build in reciprocity as a fundamental requirement into empirical interpolation schemes directed at the stopping of low-velocity ions. Examination of the SRIM and MSTAR codes reveals cases where reciprocity is obeyed accurately, but deviations of up to a factor of two are common. In case of heavy ions such as gold, electronic stopping cross sections predicted by SRIM are asserted to be almost an order of magnitude too high. (authors)

  20. Simulation on effect of stopping nuclear power generation

    International Nuclear Information System (INIS)

    Yajima, Masayuki; Kumakura, Osamu; Sakurai, Norihisa; Nagata, Yutaka; Hattori, Tsuneaki

    1990-01-01

    The effects that the stopping of nuclear power generation exerts on the price of primary energy such as petroleum, LNG and coal and the trend of Japanese energy and economy are analyzed by using the medium term economy forecasting system. In the simulation, the case of stopping nuclear power generation in seven countries of OECD is supposed, and as for the process of stopping, two cases of immediate stopping and stopping by gradual reduction are set up. The models used for the simulation are the world energy model, the competition among energies model and the multiple category model. By the decrease of nuclear power generation, thermal power generation increases, and the demand of fossil fuel increases. As the result, the price of fossil fuel rises (the world energy model), and the price of fossil fuel imported to Japan rises. Also the quantity of fossil fuel import to Japan increase. These price rise and quantity increase exert deflation effect to Japanese economy (the multiple category model). The price rise of fossil fuel affects the competition among energies in Japan through the relative change of secondary energy price (the competition among energies model). The impact to the world and to Japan is discussed. (K.I.)

  1. Reciprocity in the electronic stopping of slow ions in matter

    Science.gov (United States)

    Sigmund, P.

    2008-04-01

    The principle of reciprocity, i.e., the invariance of the inelastic excitation in ion-atom collisions against interchange of projectile and target, has been applied to the electronic stopping cross section of low-velocity ions and tested empirically on ion-target combinations supported by a more or less adequate amount of experimental data. Reciprocity is well obeyed (within ~10%) for many systems studied, and deviations exceeding ~20% are exceptional. Systematic deviations such as gas-solid or metal-insulator differences have been looked for but not identified on the present basis. A direct consequence of reciprocity is the equivalence of Z1 with Z2 structure for random slowing down. This feature is reasonably well supported empirically for ion-target combinations involving carbon, nitrogen, aluminium and argon. Reciprocity may be utilized as a criterion to reject questionable experimental data. In cases where a certain stopping cross section has not been or cannot be measured, the stopping cross section for the inverted system may be available and serve as a first estimate. It is suggested to build in reciprocity as a fundamental requirement into empirical interpolation schemes directed at the stopping of low-velocity ions. Examination of the SRIM and MSTAR codes reveals cases where reciprocity is obeyed accurately, but deviations of up to a factor of two are common. In case of heavy ions such as gold, electronic stopping cross sections predicted by SRIM are asserted to be almost an order of magnitude too high.

  2. Programmer's guide for the CC3 computer models of the concept for disposal of Canada's nuclear fuel waste

    International Nuclear Information System (INIS)

    Dougan, K.D.

    1996-11-01

    Atomic Energy of Canada Limited (AECL) is assessing a concept for disposing of CANDU reactor fuel waste in a vault deep in plutonic rock of the Canadian Shield. A computer program called the Systems Variability Analysis Code (SYVAC) was developed as an analytical tool for the postclosure (long-term) assessment of the concept, and for environmental assessments of other systems. SYVAC3, the third generation of the code, is an executive program that directs repeated simulation of the disposal system, which is described by the CC3 (Canadian Concept, generation 3) model. The CC3 model is comprised of the disposal vault submodel, the local geosphere submodel and the biosphere submodel. The CC3 Proarammer's Guide describes the programming philosophy and programming conventions not covered in the project standards. The guide includes a description of the overall logic for the CC3 vault, geosphere, and biosphere submodels. Each of the CC3 submodels is also isolated from the other two submbdels to create autonomous or 'stand-alone' submodels. The techniques used to isolate a CC3 submodel, and in particular to determine the submodells input and output data interface, are described. Structure charts are provided for the CC3 model and stand-alone submodels. This guide is meant as a companion document to the CC3 User's Manual. This guide does not describe how to use the CC3 software. The user should consult the CC3 User's Manual to determine how to configure, compile, link, and run the CC3 source code, as well as how to modify the data in the input files. It is intended that the CC3 code version CC305 be executed with SYVAC3 version SV309 and the Modelling Algorithm Library (ML3) version ML303, both developed for the assessment of the concept. SYVAC3-CC3-ML3 (also referred to as 'SC3') can be run on any platform containing an ANSI FORTRAN 77 compliant compiler. Recommended hardware environments are specified in the CC3 User's Manual. (author)

  3. Emergence of a novel subpopulation of CC398 Staphylococcus aureus infecting animals is a serious hazard for humans

    Directory of Open Access Journals (Sweden)

    Nathalie Laure Van Der Mee-Marquet

    2014-12-01

    Full Text Available Until recently, Staphylococcus aureus from clonal complex (CC398 were mostly described as colonizing asymptomatic raised pigs and pig-farmers. Currently, the epidemiology of the CC398 lineage is becoming more complex. CC398 human-adapted isolates are increasingly being identified in bloodstream infections in humans living in animal-free environments. In addition, CC398 isolates are increasingly responsible for invasive infections in various animals. CC398 isolates that colonize asymptomatic pigs and the isolates that infect humans living in animal-free environments (human-adapted isolates both lack several clinically important S. aureus–associated virulence factors but differ on the basis of their prophage content. Recent findings have provided insight into the influence of a φMR11-like helper prophage on the ability of CC398 isolates to infect humans. To assess the recent spread of the CC398 lineage to various animal species and to investigate the links between the φMR11-like prophage and the emergence of CC398 isolates infecting animals, we studied 277 isolates causing infections in unrelated animals. The prevalence of CC398 isolates increased significantly between 2007 and 2013 (p<0.001; 31.8 % of the animal isolates harbored the φMR11-like prophage. High-density DNA microarray experiments with 37 representative infected-animal isolates positive for φMR11-like DNA established that most infected-animal isolates carried many genetic elements related to antimicrobial resistance and virulence genes, and a φ3 prophage encoding immune-modulating proteins and associated with animal-to-human jumps. Our findings suggest recent clonal expansion and dissemination of a new subpopulation of CC398 isolates, responsible for invasive infections in various animals, with a considerable potential to colonize and infect humans, probably greater than that of human-adapted CC398 isolates, justifying active surveillance.

  4. Services Delivery for Displaced Rural Workers: A North Carolina Case Study of the Theory and Reality of One-Stop

    Directory of Open Access Journals (Sweden)

    Leslie Hossfeld

    2008-10-01

    Full Text Available The United States has felt the brunt of a number of natural and economic crises that are taking a devastating toll on many rural communities, especially in the South. Congress passed the WIA which required the formation of locally based one-stop service systems to deliver the majority of employment and training services funded by the federal government . The one-stop career system was envisioned as a system that would consolidate programs, resources, and services such as unemployment insurance, state job services, public assistance, training programs, and career services. Four principles guided the system's development: 1 Universal access to all population groups including both job seekers and employers; 2 Customer choice based on the consumers’ evaluation of his/her needs; 3 Service integration and; 4 Performance-based accountability. One-stop does not seem to be working very well. Suggestions for improvement are discussed.

  5. Stopping and energy deposition of hadrons in target nuclei

    International Nuclear Information System (INIS)

    Strugalski, Z.

    1983-01-01

    In an analysis of pion-xenon nucleus collisions at 2.34-9 GeV/c momentum events are identified in which incident pions were completely stopped and deposited their energy in target nucleus. Probability of appearance of such ''stopped'' events among any-type pion-xenon collision events depends on the incident pion momentum and is: approximately 0.15 at 2.34 GeV/c, approximately 0.02 at 3.5 GeV/c, and approximately 0 at higher momenta. Formula expressing probability of appearance of the ''stopped'' events is derived. Range-energy relation in nuclear matter for pions and protons is given

  6. Proposal for a CINDA-type stopping data bibliography (CISDA)

    International Nuclear Information System (INIS)

    Ivascu, M.; Bucurescu, D.; Avrigeanu, V.

    1980-11-01

    The present status and requirements of stopping power data (SD) are reviewed, by considering the significant trends in applications of nuclear data. The need of centralized information on SD is emphasized. If the establishing of compiled and evaluated SD libraries format is possible only through an internationally co-ordinated action, to produce a computerized index to bibliographic references on SD is an easier task. One describes a plan of a CINDA-type SD bibliography (named CISDA - Computer Index of Stopping Data) containing experimental, theoretical and evaluated works for stopping powers, range, energy and range straggling of ions with atomic mass and charge both larger than or equal to 1. The index organization and detailed field descriptions of reference records are presented. (author)

  7. New developments in stopping power for fast ions

    International Nuclear Information System (INIS)

    Paul, Helmut

    2007-01-01

    We discuss the available stopping power tables and codes, and new experimental methods. Among the semi-empirical stopping power tables, SRIM and MSTAR describe experimental data best. Of the recent theoretical stopping codes CasP, PASS, TCS and dielectric formalism, all describe some data well. PASS is the only theoretical code with an extended table for many ions and targets, but on the average, its predictive value at low energies is less than that of SRIM or MSTAR. The first-principle extended classical trajectory Monte Carlo method is very promising. The ToF-E ERDA arrangements have made it possible to produce accurate data for many ion-target combinations. A new liquid jet target method promises data for liquid water which is an important substance for medical dosimetry

  8. Ball Screw Actuator Including a Compliant Ball Screw Stop

    Science.gov (United States)

    Wingett, Paul T. (Inventor); Hanlon, Casey (Inventor)

    2017-01-01

    An actuator includes a ball nut, a ball screw, and a ball screw stop. The ball nut is adapted to receive an input torque and in response rotates and supplies a drive force. The ball screw extends through the ball nut and has a first end and a second end. The ball screw receives the drive force from the ball nut and in response selectively translates between a retract position and a extend position. The ball screw stop is mounted on the ball screw proximate the first end to translate therewith. The ball screw stop engages the ball nut when the ball screw is in the extend position, translates, with compliance, a predetermined distance toward the first end upon engaging the ball nut, and prevents further rotation of the ball screw upon translating the predetermined distance.

  9. Ball Screw Actuator Including an Axial Soft Stop

    Science.gov (United States)

    Wingett, Paul T. (Inventor); Forrest, Steven Talbert (Inventor); Abel, Steve (Inventor); Woessner, George (Inventor); Hanlon, Casey (Inventor)

    2016-01-01

    An actuator includes an actuator housing, a ball screw, and an axial soft stop assembly. The ball screw extends through the actuator housing and has a first end and a second end. The ball screw is coupled to receive a drive force and is configured, upon receipt of the drive force, to selectively move in a retract direction and an extend direction. The axial soft stop assembly is disposed within the actuator housing. The axial soft stop assembly is configured to be selectively engaged by the ball screw and, upon being engaged thereby, to translate, with compliance, a predetermined distance in the extend direction, and to prevent further movement of the ball screw upon translating the predetermined distance.

  10. Why do People Stop Playing On-Line Games?

    DEFF Research Database (Denmark)

    Sudzina, Frantisek; Razmerita, Liana

    2012-01-01

    The recent initial public offering of shares of Zynga, probably the most important on-line game provider, drew interest of potential investors but also of general public to their business model. What the most interested people learned so far is that if Zynga had not changed their accounting...... practice, they would be in red numbers for several months already. This is most likely caused by people stopping to play their games. This paper provides an estimate of what proportion of people, who played on-line games, already stopped playing them. Additionally, it analyzed the reasons why people...... stopped playing on-line games. It also compares Facebook and other on-line games....

  11. Fricative-stop coarticulation: acoustic and perceptual evidence.

    Science.gov (United States)

    Repp, B H; Mann, V A

    1982-06-01

    Eight native speakers of American English each produced ten tokens of all possible CV, FCV, and VFCV utterances with V = [a] or [u], F = [s] or [integral of], and C = [t] or [k]. Acoustic analysis showed that the formant transition onsets following the stop consonant release were systematically influenced by the preceding fricative, although there were large individual differences. In particular, F3 and F4 tended to be higher following [s] than following [integral of]. The coarticulatory effects were equally large in FCV (e.g.,/sta/) and VFCV (e.g.,/asda/) utterances; that is, they were not reduced when a syllable boundary intervened between fricative and stop. In a parallel perceptual study, the CV portions of these utterances (with release bursts removed to provoke errors) were presented to listeners for identification of the stop consonant. The pattern of place-of-articulation confusions, too, revealed coarticulatory effects due to the excised fricative context.

  12. Companion classroom activities for "stop faking it!" force and motion

    CERN Document Server

    Robertson, William C

    2011-01-01

    Never has it been so easy for educators to learn to teach physical science with confidence. Award-winning author Bill Robertson launched his bestselling Stop Faking It! series in 2002 with Force and Motion--offering elementary and middle school teachers a jargon-free way to learn the background for teaching physical science with confidence. Combining easy-to-understand if irreverent explanations and quirky diagrams, Stop Faking It! Force and Motion helped thousands of teachers, parents, and homeschoolers conquer topics from Newton s laws to the physics of space travel. Now Companion Classroom Activities for Stop Faking It! Force and Motion proves an ideal supplement to the original book or a valuable resource of its own. The hands-on activities and highly readable explanations allow students to first investigate concepts, then discuss learned concepts, and finally apply the concepts to everyday situations. Robertson's wit and humor are sure to keep students and teachers entertained while they tackle topics ...

  13. [Spread of genetically related methicillin-susceptible Staphylococcus aureus belonging to CC45, in healthy nasal carriers in Child Day Care Centers of Medellin, Colombia].

    Science.gov (United States)

    Rodríguez-Tamayo, Erika Andrea; Ruiz-Cadavid, Alejandra; Sánchez-González, Leidy Maritza; García-Valencia, Natalia; Jiménez-Quiceno, Judy Natalia

    2016-03-01

    Colonization plays a major role in the epidemiology and pathogenesis of Staphylococcus aureus infections. The child population is one of the most susceptible to colonization; however, community and children studies are limited in Colombia. To assess the clonal relationship of S.aureus strains isolated from colonized children in eight day care centers (DCCs) from Medellin and to determine the presence of epidemiological characteristics in these populations. An observational cross-sectional study was conducted on a sample of 200 children aged from 6 months to 5 years attending eight DCCs in Medellin, Colombia, during 2011. Nasal samples were collected from each nostril. The isolates species and methicillin resistance were molecularly confirmed using nuc and mec genes. Genotypic analysis included SCCmec typing, spa typing, PFGE and MLST. Epidemiological information was obtained from the parents and analyzed using the statistics program SPSS 21.0 RESULTS: The colonization frequency in DCCs ranged from 16.7% (n=3) to 53.6% (n=15). Genetically related isolates were identified inside four DCCs. Half (50%) of the isolates were grouped in 3 clusters, which belonged to the clonal complexes CC45, CC30, and CC121. Molecular typing of isolates from colonized children and comparison among DCCs showed the spread of colonizing strains inside DCCs in Medellin; predominantly the CC45 clone, a successful child colonizer. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  14. 49 CFR 392.22 - Emergency signals; stopped commercial motor vehicles.

    Science.gov (United States)

    2010-10-01

    ... REGULATIONS DRIVING OF COMMERCIAL MOTOR VEHICLES Stopped Commercial Motor Vehicles § 392.22 Emergency signals; stopped commercial motor vehicles. (a) Hazard warning signal flashers. Whenever a commercial motor vehicle... than necessary traffic stops, the driver of the stopped commercial motor vehicle shall immediately...

  15. Can I Stop Myself From Having a Wet Dream? (For Teens)

    Science.gov (United States)

    ... Can I Stop Myself From Having a Wet Dream? KidsHealth / For Teens / Can I Stop Myself From Having a Wet Dream? Print Can I stop myself from having a wet dream? – Tom* You really can't stop wet dreams, ...

  16. One-stop endoscopic hernia surgery: efficient and satisfactory.

    Science.gov (United States)

    Voorbrood, C E H; Burgmans, J P J; Clevers, G J; Davids, P H P; Verleisdonk, E J M M; Schouten, N; van Dalen, T

    2015-06-01

    One-stop surgery offers patients diagnostic work-up and subsequent surgical treatment on the same day. In the present study, patient satisfaction and efficiency from an institutional perspective were evaluated in patients who were referred for one-stop endoscopic inguinal hernia repair. In a high-volume inguinal hernia clinic, all consecutive patients referred for one-stop surgical treatment, were registered prospectively. An instructed secretary screened patients for eligibility for the one-stop option when the appointment was made. Totally extraperitoneal hernia repair under general anaesthesia was the preferred operative technique. Patient's satisfaction, successful day surgery and institutional efficiency were evaluated. Between January 2010 and January 2012 a total of 349 patients (17 % of all patients in the hernia clinic) were referred for one-stop hernia repair. Mean age was 47.5 years and 96.3 % were males. Three hundred thirty-six patients underwent hernia surgery on the same day (96.3 %). In thirteen patients (3.7 %) no operative repair was done on the day of presentation due to an incorrect diagnosis (n = 7), a watchful waiting policy for asymptomatic hernia (n = 3), rescheduling due to a large scrotal hernia, and there were two "no shows". Following hernia repair 97 % of the patients were discharged on the same day, while ten patients required hospitalization. Based on the questionnaires the main satisfaction score among patients was 9.0 (8.89-9.17 95 % CI) on a scale ranging from 0 to 10. One-stop hernia surgery is feasible and satisfactory from an institutional as well as from a patient's perspective.

  17. A Conceptual Approach for Optimising Bus Stop Spacing

    Science.gov (United States)

    Johar, Amita; Jain, S. S.; Garg, P. k.

    2017-06-01

    An efficient public transportation system is essential of any country. The growth, development and shape of the urban areas are mainly due to availability of good transportation (Shah et al. in Inst Town Plan India J 5(3):50-59, 1). In developing countries, like India, travel by local bus in a city is very common. The accidents, congestion, pollution and appropriate location of bus stops are the major problems arising in metropolitan cities. Among all the metropolitan cities in India, Delhi has highest percentage of growth of population and vehicles. Therefore, it is important to adopt efficient and effective ways to improve mobility in different metropolitan cities in order to overcome the problem and to reduce the number of private vehicles on the road. The primary objective of this paper is to present a methodology for developing a model for optimum bus stop spacing (OBSS). It describes the evaluation of existing urban bus route, data collection, development of model for optimizing urban bus route and application of model. In this work, the bus passenger generalized cost method is used to optimize the spacing between bus stops. For the development of model, a computer program is required to be written. The applicability of the model has been evaluated by taking the data of urban bus route of Delhi Transport Corporation (DTC) in Excel sheet in first phase. Later on, it is proposed to develop a programming in C++ language. The developed model is expected to be useful to transport planner for rational design of the spacing of bus stops to save travel time and to generalize operating cost. After analysis it is found that spacing between the bus stop comes out to be between 250 and 500 m. The Proposed Spacing of bus stops is done considering the points that they don't come nearer to metro/rail station, entry or exit of flyover and near traffic signal.

  18. Light stops and fine-tuning in MSSM

    Energy Technology Data Exchange (ETDEWEB)

    Cici, Ali; Kirca, Zerrin; Uen, Cem Salih [Uludag Univ., Department of Physics, Bursa (Turkey)

    2018-01-15

    We discuss the fine-tuning issue within the MSSM framework. Following the idea that the fine-tuning can measure effects of some missing mechanism, we impose non-universal gaugino masses at the GUT scale, and explore the low scale implications. We realize that the fine-tuning parametrized with Δ{sub EW} can be as low as zero. We consider the stop mass with a special importance and focus on the mass scales as m{sub t} ≤ 700 GeV, which are excluded by the current experiments when the stop decays into a neutralino along with a top quark or a chargino along with a bottom quark. We find that the stop mass can be as low as about 250 GeV with Δ{sub EW} ∝ 50. We find that the solutions in this region can be excluded only up to 60% when stop decays into a neutralino-top quark, and 50% when it decays into a chargino-b quark. Setting 65% CL to be potential exclusion and 95% to be pure exclusion limit such solutions will be tested in near future experiments, which are conducted with higher luminosity. In addition to stop, the region with low fine-tuning and light stops predicts masses for the other supersymmetric particles such as m{sub b} >or similar 700 GeV, m{sub τ} >or similar 1 TeV, m{sub χ{sub 1}{sup {sub ±}}} >or similar 120 GeV. The details for the mass scales and decay rates are also provided by tables of benchmark points. (orig.)

  19. Light stops and fine-tuning in MSSM

    Science.gov (United States)

    Çiçi, Ali; Kırca, Zerrin; Ün, Cem Salih

    2018-01-01

    We discuss the fine-tuning issue within the MSSM framework. Following the idea that the fine-tuning can measure effects of some missing mechanism, we impose non-universal gaugino masses at the GUT scale, and explore the low scale implications. We realize that the fine-tuning parametrized with Δ _{EW} can be as low as zero. We consider the stop mass with a special importance and focus on the mass scales as m_{\\tilde{t}} ≤ 700 GeV, which are excluded by the current experiments when the stop decays into a neutralino along with a top quark or a chargino along with a bottom quark. We find that the stop mass can be as low as about 250 GeV with Δ _{EW} ˜ 50. We find that the solutions in this region can be exluded only up to 60% when stop decays into a neutralino-top quark, and 50% when it decays into a chargino-b quark. Setting 65% CL to be potential exclusion and 95% to be pure exclusion limit such solutions will be tested in near future experiments, which are conducted with higher luminosity. In addition to stop, the region with low fine-tuning and light stops predicts masses for the other supersymmetric particles such as m_{\\tilde{b}} ≳ 700 GeV, m_{\\tilde{τ }} ≳ 1 TeV, m_{\\tilde{χ }1^{± }} ≳ 120 GeV. The details for the mass scales and decay rates are also provided by tables of benchmark points.

  20. Narrowing the Broader Autism Phenotype: A Study Using the Communication Checklist-Adult Version (CC-A)

    Science.gov (United States)

    Whitehouse, Andrew J. O.; Coon, Hilary; Miller, Judith; Salisbury, Bryanna; Bishop, Dorothy V. M.

    2010-01-01

    This study investigated whether the Communication Checklist-Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands and their parents. The CC-A is divided into subscales measuring linguistic ability as well as two aspects of social communication: the Pragmatic Skills subscale assesses the level of pragmatic…

  1. 32 CFR Appendix E to Part 57 - DoD-CC on Early Intervention, Special Education, and Related Services

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false DoD-CC on Early Intervention, Special Education... SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN PROVISION OF EARLY INTERVENTION AND SPECIAL EDUCATION..., Special Education, and Related Services A. Committee Membership The DoD-CC shall meet at least yearly to...

  2. One-stop-shop treatment for basal cell carcinoma, part of a new disease management strategy.

    Science.gov (United States)

    van der Geer, S; Frunt, M; Romero, H L; Dellaert, N P; Jansen-Vullers, M H; Demeyere, T B J; Neumann, H A M; Krekels, G A M

    2012-09-01

    The number of skin cancer patients, especially patients with basal cell carcinoma (BCC), is rapidly increasing. Resources available at dermato-oncology units have not increased proportionally, which affects the throughput time of patients. To assess the feasibility and safety of implementation of the one-stop-shop concept for the treatment of patients with BCC at a dermato-oncology unit. A pilot study on a one-stop-shop concept for BCC was performed to investigate procedure safety and patient satisfaction. Fresh frozen sections were used to diagnose the tumours, and subsequently treatment with photodynamic therapy or excision was performed on the same day. Time spent in the hospital was measured and questionnaires were used to evaluate patient satisfaction. Sixteen patients, who together had 19 tumours, were included. Diagnoses were made within a mean time of 100 min (range 27-160 min). The mean throughput time was 4 hours and 7 min (range 60-420 min). No complications were observed, and patient satisfaction was high. The one-stop-shop concept for the treatment of skin cancer patients is feasible and efficient for both patients and dermato-oncology units. Further research is necessary to investigate cost-effectiveness when larger patient groups are involved. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

  3. International Symposium of Scientists for Nuclear test Stopping

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Problems discussed at International Symposium of Scientists for Nuclear Test Stopping in July 1986 in Moscow were considered. Scientists discussed complex of possible measures directed at strengthening of peace supporting mechanism, spoke in support of prohibition of all nuclear weapon tests. Necessity of measures preventing the weapon delivery to space, construction of the regime of using cosmic equipment exclusively for peace was noted. Attention was paid to the problem of control for test stopping (by means of sattelites and seismic methods), cooperation establishment between the USSR Academy of Sciences and the Council for the protection of the USA Natural Resources

  4. Anatomy of maximal stop mixing in the MSSM

    International Nuclear Information System (INIS)

    Bruemmer, Felix; Kraml, Sabine; Kulkarni, Suchita

    2012-05-01

    A Standard Model-like Higgs near 125 GeV in the MSSM requires multi-TeV stop masses, or a near-maximal contribution to its mass from stop mixing. We investigate the maximal mixing scenario, and in particular its prospects for being realized it in potentially realistic GUT models. We work out constraints on the possible GUT-scale soft terms, which we compare with what can be obtained from some well-known mechanisms of SUSY breaking mediation. Finally, we analyze two promising scenarios in detail, namely gaugino mediation and gravity mediation with non-universal Higgs masses.

  5. Anatomy of maximal stop mixing in the MSSM

    Energy Technology Data Exchange (ETDEWEB)

    Bruemmer, Felix [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Kraml, Sabine; Kulkarni, Suchita [CNRS/IN2P3, INPG, Grenoble (France). Laboratoire de Physique Subatomique et de Cosmologie

    2012-05-15

    A Standard Model-like Higgs near 125 GeV in the MSSM requires multi-TeV stop masses, or a near-maximal contribution to its mass from stop mixing. We investigate the maximal mixing scenario, and in particular its prospects for being realized it in potentially realistic GUT models. We work out constraints on the possible GUT-scale soft terms, which we compare with what can be obtained from some well-known mechanisms of SUSY breaking mediation. Finally, we analyze two promising scenarios in detail, namely gaugino mediation and gravity mediation with non-universal Higgs masses.

  6. Summary the race to reinvent energy and stop global warming

    CERN Document Server

    2013-01-01

    Complete summary of Fred Krupp and Miriam Horn's book: ""Earth: The Sequel: The Race to Reinvent Energy and Stop Global Warming"". This summary of the ideas from Fred Krupp and Miriam Horn's book ""Earth: The Sequel"" explains how capitalism, as the most powerful economic force in the world, is the only engine of change that has the strength to stop global warming. In their book, the authors demonstrate how this can be achieved by installing a cap-and-trade initiative, providing genuine economic incentives for companies and reducing their carbon footprint. This summary explains their theory in

  7. Maintenance cost savings - snubber elimination with limit stops

    International Nuclear Information System (INIS)

    Monette, P.; Baltus, R.; Cloud, R.L.

    1995-01-01

    ''Active'' snubbers can be replaced with ''passive'' Limit Stops using two separate strategies. One is a straightforward piping re-analysis to optimize the number of dynamics supports and replace remaining snubbers with Limit Stops. A second approach is to take implicit advantage of the margins afforded by the ASME Code Case N-411 damping ratios and simply replace snubbers one-for-one with no re-analysis. Both methods result in major maintenance cost savings and both have been received favorably by the USNRC (United States Nuclear Regulatory Commission). Approaches to maintenance cost reduction using these strategies are discussed in this paper. (Author). 11 refs., 4 figs

  8. Maintenance cost savings - snubber elimination with limit stops

    International Nuclear Information System (INIS)

    Cloud, R.L.; Taylor, W.H.

    1993-01-01

    'Active' snubbers can be replaced with 'passive' Limit Stops using two separate strategies. One is a straightforward piping re-analysis to optimize the number of dynamic supports and replace remaining snubbers with Limit Stops. A second approach is to take implicit advantage of the margins afforded by the ASME Code Case N-411 reduced damping ratios and simply replace snubbers one-for-one with no re-analysis. Both methods result in major maintenance cost savings and both have been discussed with the NRC. Approaches to maintenance cost reduction using these strategies are discussed in this paper

  9. Cacao 3 (Cc 3, Arte rupestre del formativo temprano en Antofagasta de la Sierra, Catamarca, Argentina

    Directory of Open Access Journals (Sweden)

    Alvaro Rodrigo Martel

    2004-01-01

    Full Text Available En el presente trabajo hemos abordado el estudio de la producción del arte rupestre del sitio Cacao 3 –Cc3- (Antofagasta de la Sierra, Catamarca con relación a las prácticas socioculturales de grupos agropastoriles del periodo Formativo Temprano en la Puna meridional argentina, haciendo hincapié en el emplazamiento del sitio y su asociación contextual con las demás evidencias arqueológicas conocidas para el área de estudio y estableciendo las relaciones entre las manifestaciones rupestres de Cc3 con las de otros sitios, a nivel micro y macrorregional, a través de indicadores estilísticos

  10. Scaling animal to human biodistribution of the radiopharmaceutical [68Ga]Ga-PSMA-HBED-CC

    Energy Technology Data Exchange (ETDEWEB)

    Parra, Pamela Ochoa, E-mail: lapochoap@unal.edu.co; Veloza, Stella [Grupo de Física Nuclear, Departamento de Física, Universidad Nacional de Colombia, Bogota, D.C. (Colombia)

    2016-07-07

    The radiotracer called {sup 68}Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) is a novel radiophar-maceutical for the detection of prostate cancer lesions by positron emission tomography (PET) imaging. Setting up a cost-effective manual synthesis of this radiotracer and making its clinical translation in Colombia will require two important elements: the evaluation of the procedure to yield a consistent product, meeting standards of radio-chemical purity and low toxicity and then, the evaluation of the radiation dosimetry. In this paper a protocol to extrapolate the biokinetic model made in normal mice to humans by using the computer software for internal dose assessment OLINDA/EXM® is presented as an accurate and standardized method for the calculation of radiation dosimetry estimates.

  11. ccPDB: compilation and creation of data sets from Protein Data Bank.

    Science.gov (United States)

    Singh, Harinder; Chauhan, Jagat Singh; Gromiha, M Michael; Raghava, Gajendra P S

    2012-01-01

    ccPDB (http://crdd.osdd.net/raghava/ccpdb/) is a database of data sets compiled from the literature and Protein Data Bank (PDB). First, we collected and compiled data sets from the literature used for developing bioinformatics methods to annotate the structure and function of proteins. Second, data sets were derived from the latest release of PDB using standard protocols. Third, we developed a powerful module for creating a wide range of customized data sets from the current release of PDB. This is a flexible module that allows users to create data sets using a simple six step procedure. In addition, a number of web services have been integrated in ccPDB, which include submission of jobs on PDB-based servers, annotation of protein structures and generation of patterns. This database maintains >30 types of data sets such as secondary structure, tight-turns, nucleotide interacting residues, metals interacting residues, DNA/RNA binding residues and so on.

  12. Substrate-Mediated C-C and C-H Coupling after Dehalogenation.

    Science.gov (United States)

    Kong, Huihui; Yang, Sha; Gao, Hongying; Timmer, Alexander; Hill, Jonathan P; Díaz Arado, Oscar; Mönig, Harry; Huang, Xinyan; Tang, Qin; Ji, Qingmin; Liu, Wei; Fuchs, Harald

    2017-03-15

    Intermolecular C-C coupling after cleavage of C-X (mostly, X = Br or I) bonds has been extensively studied for facilitating the synthesis of polymeric nanostructures. However, the accidental appearance of C-H coupling at the terminal carbon atoms would limit the successive extension of covalent polymers. To our knowledge, the selective C-H coupling after dehalogenation has not so far been reported, which may illuminate another interesting field of chemical synthesis on surfaces besides in situ fabrication of polymers, i.e., synthesis of novel organic molecules. By combining STM imaging, XPS analysis, and DFT calculations, we have achieved predominant C-C coupling on Au(111) and more interestingly selective C-H coupling on Ag(111), which in turn leads to selective synthesis of polymeric chains or new organic molecules.

  13. The inclusive decay b→cc{sup ¯}s revisited

    Energy Technology Data Exchange (ETDEWEB)

    Krinner, Fabian, E-mail: fabian-krinner@mytum.de [Physik-Department, Technische Universität München, James-Franck-Straße, 85748 Garching (Germany); Lenz, Alexander [Institute for Particle Physics and Phenomenology, Durham University, Durham DH1 3LE (United Kingdom); CERN – Theory Division, PH-TH, Case C01600, CH-1211 Geneva 23 (Switzerland); Rauh, Thomas [Physik-Department, Technische Universität München, James-Franck-Straße, 85748 Garching (Germany)

    2013-11-01

    The inclusive decay rate b→cc{sup ¯}s is enhanced considerably due to perturbative QCD corrections. We recalculate the dominant part of the NLO–QCD corrections, because they cannot be reconstructed from the literature and we give the full expressions in this paper. Further we include some previously neglected corrections originating from penguin diagrams. Combined with the impressive progress in the accurate determination of input parameters like charm quark mass, bottom quark mass and CKM parameters, this enables us to make a very precise prediction of the corresponding branching ratio Br(b→cc{sup ¯}s)=(23±2)%. This result is an essential ingredient for a model and even decay channel independent search for new physics effects in B decays.

  14. The CC-Bio Project: Studying the Effects of Climate Change on Quebec Biodiversity

    Directory of Open Access Journals (Sweden)

    Luc Vescovi

    2010-11-01

    Full Text Available Anticipating the effects of climate change on biodiversity is now critical for managing wild species and ecosystems. Climate change is a global driver and thus affects biodiversity globally. However, land-use planners and natural resource managers need regional or even local predictions. This provides scientists with formidable challenges given the poor documentation of biodiversity and its complex relationships with climate. We are approaching this problem in Quebec, Canada, through the CC-Bio Project (http://cc‑bio.uqar.ca/, using a boundary organization as a catalyst for team work involving climate modelers, biologists, naturalists, and biodiversity managers. In this paper we present the CC-Bio Project and its general approach, some preliminary results, the emerging hypothesis of the northern biodiversity paradox (a potential increase of biodiversity in northern ecosystems due to climate change, and an early assessment of the conservation implications generated by our team work.

  15. Quick Way to Port Existing C/C++ Chemoinformatics Toolkits to the Web Using Emscripten.

    Science.gov (United States)

    Jiang, Chen; Jin, Xi

    2017-10-23

    Emscripten is a special open source compiler that compiles C and C++ code into JavaScript. By utilizing this compiler, some typical C/C++ chemoinformatics toolkits and libraries are quickly ported to to web. The compiled JavaScript files have sizes similar to native programs, and from a series of constructed benchmarks, the performance of the compiled JavaScript codes is also close to that of the native codes and is better than the handwritten JavaScript codes. Therefore, we believe that Emscripten is a feasible and practical tool for reusing existing C/C++ codes on the web, and many other chemoinformatics or molecular calculation software tools can also be easily ported by Emscripten.

  16. Rhenium-Promoted C-C Bond-Cleavage Reactions of Internal Propargyl Alcohols.

    Science.gov (United States)

    Lee, Kui Fun; Bai, Wei; Sung, Herman H Y; Williams, Ian D; Lin, Zhenyang; Jia, Guochen

    2018-06-07

    The first examples of C-C bond cleavage reactions of internal propargyl alcohols to give vinylidene complexes are described. Treatment of [Re(dppm) 3 ]I with RC≡CC(OH)R'R'' (R=aryl, alkyl; C(OH)R'R''=C(OH)Ph 2, C(OH)Me 2 , C(OH)HPh, C(OH)H 2 ) produced the vinylidene complexes ReI(=C=CHR)(dppm) 2 with the elimination of C(O)R'R''. Computational studies support that the reactions proceed through a β-alkynyl elimination of alkoxide intermediates Re{OC(R')(R'')C≡CR}(dppm) 2 . © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Hubble Space Telescope Ultraviolet Light Curves Reveal Interesting Properties of CC Sculptoris and RZ Leonis

    Energy Technology Data Exchange (ETDEWEB)

    Szkody, Paula; Mukadam, Anjum S. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Toloza, Odette; Gänsicke, Boris T.; Pala, Anna F. [Department of Physics, University of Warwick, Coventry CV4 7AL (United Kingdom); Dai, Zhibin [Yunnan Observatories, Chinese Academy of Sciences, 396 Yangfangwang, Guandu District, Kunming, 650216 (China); Waagen, Elizabeth O. [AAVSO, 48 Bay State Rd, Cambridge, MA 02138 (United States); Godon, Patrick; Sion, Edward M., E-mail: szkody@astro.washington.edu [Department of Astrophysics and Planetary Science, Villanova University, Villanova, PA 19085 (United States)

    2017-03-01

    Time-tag ultraviolet data obtained on the Hubble Space Telescope in 2013 reveal interesting variability related to the white dwarf spin in the two cataclysmic variables RZ Leo and CC Scl. RZ Leo shows a period at 220 s and its harmonic at 110 s, thus identifying it as a likely Intermediate Polar (IP). The spin signal is not visible in a short single night of ground-based data in 2016, but the shorter exposures in that data set indicate a possible partial eclipse. The much larger UV amplitude of the spin signal in the known IP CC Scl allows the spin of 389 s, previously only seen at outburst, to be visible at quiescence. Spectra created from the peaks and troughs of the spin times indicate a hotter temperature of several thousand degrees during the peak phases, with multiple components contributing to the UV light.

  18. Effects of X-rays on CC-chemokine receptor 7 expression in human lung cancer A549 cells

    International Nuclear Information System (INIS)

    Wang Cuilan; Jiang Qisheng; Zou Yue; Li Fengsheng; Li Wei; Song Xiujun; He Rui; Wang Lu

    2011-01-01

    Objective: To study the effects of X-ray radiation on CC-chemokine receptor 7 (CCR7) expression in human non-small cell lung cancer (NSCLC) cells. Methods: Human adenocarcinoma cells of the line A549 were cultured and irradiated by X-ray at the absorbed doses of 2, 4, 6, and 8 Gy respectively by linear accelerator (with the source skin distance of 100 cm and dose rate of 442.89 cGy/min). The relative levels of CCR7 mRNA and protein expression in the A549 cells were respectively detected by real time-PCR and Western blotting 4, 12, 24, 48, and 72 h after radiation.Untreated A549 cells were used as control group. Results: The expression levels of CCR7 mRNA and protein in the A549 cells began to increase since 4 h after radiation and then decreased gradually after they reached the peak. The CCR7 mRNA expression levels 72 h after radiation of the 6 and 8 Gy groups were still significantly higher than those of the control group (t=6.75-7.26, both P<0.01), and the CCR7 protein expression levels of the 2 and 6 Gy group were still significantly higher than those of the control group (t=11.13-14.17, both P<0.01). Then the CCR7 protein expression levels of the 4 and 8 Gy groups decreased to the control group level 48 and 72 h after radiation respectively. Conclusions: The CCR7 mRNA and protein expression levels in the NSCLC cells increase after X-ray irradiation,which may be correlated with the promotion of proliferation and metastasis of NSCLC cells by X-ray irradiation at a certain dose. (authors)

  19. Clinical factors influencing normalization of prothrombin time after stopping warfarin: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Zondag Michelle

    2008-10-01

    Full Text Available Abstract Background Anticoagulation with warfarin should be stopped 4–6 days before invasive procedures to avoid bleeding complications. Despite this routine, some patients still have high International Normalized Ratio (INR values on the day of surgery and the procedure may be cancelled. We sought to identify easily available clinical characteristics that may influence the rate of normalization of prothrombin time when warfarin is stopped before surgery or invasive procedures. Methods Clinical data were collected retrospectively from consecutive cases from two cohorts, who stopped warfarin 6 days before surgery. An INR value of 1.6 or higher on the day of surgery or requirement for reversal with vitamin K the day before surgery were criteria for slow return (S to normal INR. Results Of 202 patients, 14 (7% were classified as S. Eight of the S-patients required reversal with vitamin K one day before surgery and in another case surgery was cancelled due to high INR. Baseline INR was the only variable significantly associated with classification as S in stepwise logistic regression analysis (p = 0.003. The odds ratio for being in the normal group was 0.27 (95% confidence interval 0.12–0.62 for each unit baseline INR increased. The positive predictive value of baseline INR with a cut off at > 3.0 was only 15% and for INR > 3.5 it was 33%. Conclusion Baseline INR, but not the size of the maintenance dose, is associated with the rate of normalization of prothrombin time after stopping warfarin, but it has limited utility as predictor in clinical practice. Whenever normal hemostasis is considered crucial for the safety, the INR should be checked again before the invasive procedure.

  20. Complete Genome Sequence of the Endophytic Biocontrol Strain Bacillus velezensis CC09

    OpenAIRE

    Cai, Xunchao; Kang, Xingxing; Xi, Huan; Liu, Changhong; Xue, Yarong

    2016-01-01

    Bacillus velezensis is a heterotypic synonym of B. methylotrophicus, B. amyloliquefaciens subsp. plantarum, and Bacillus oryzicola, and has been used to control plant fungal diseases. In order to fully understand the genetic basis of antimicrobial capacities, we did a complete genome sequencing of the endophytic B.?velezensis strain CC09. Genes tightly associated with biocontrol ability, including nonribosomal peptide synthetases, polyketide synthetases, iron acquisition, colonization, and vo...

  1. Complete Genome Sequence of the Endophytic Biocontrol Strain Bacillus velezensis CC09.

    Science.gov (United States)

    Cai, Xunchao; Kang, Xingxing; Xi, Huan; Liu, Changhong; Xue, Yarong

    2016-09-29

    Bacillus velezensis is a heterotypic synonym of B. methylotrophicus, B. amyloliquefaciens subsp. plantarum, and Bacillus oryzicola, and has been used to control plant fungal diseases. In order to fully understand the genetic basis of antimicrobial capacities, we did a complete genome sequencing of the endophytic B. velezensis strain CC09. Genes tightly associated with biocontrol ability, including nonribosomal peptide synthetases, polyketide synthetases, iron acquisition, colonization, and volatile organic compound synthesis were identified in the genome. Copyright © 2016 Cai et al.

  2. Photoinduced C-C Cross-Coupling of Aryl Chlorides and Inert Arenes

    Directory of Open Access Journals (Sweden)

    Lele Wang

    2016-01-01

    Full Text Available Here we report a facile, efficient, and catalyst-free method to realize C-C cross-coupling of aryl chlorides and inert arenes under UV light irradiation. The aryl radical upon homolytic cleavage of C-Cl bond initiated the nucleophilic substitution reaction with inert arenes to give biaryl products. This mild reaction mode can also be applied to other synthetic reactions, such as the construction of C-N bonds and trifluoromethylated compounds.

  3. Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2004

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2005-08-31

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCC Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed. The FY 2004 budget summary for DOE Materials Activities is presented on page 8. The distribution of these funds between DOE laboratories, private industry, academia and other organizations is presented in tabular form on page 10. Following the budget summary is a set of detailed program descriptions for the FY 2004 DOE Materials activities. These descriptions are presented according to the organizational structure of the Department. A mission statement, a budget summary listing the project titles and FY 2004 funding, and detailed project summaries are presented for each Assistant Secretary office, the Office of Science, and the National Nuclear Security Administration. The project summaries also provide DOE, laboratory, academic and industrial contacts for each project, as appropriate.

  4. Energy Materials Coordinating Committee (EMaCC). Annual technical report, fiscal year 1983

    International Nuclear Information System (INIS)

    1984-03-01

    The following text briefly describes the materials research programs of the Department of Energy. It is organized by office and organizational charts are provided to allow easy identification of the materials research programs of each office. These program descriptions have been prepared from inputs submitted by many different EMaCC members. This report is not a comprehensive summary of the Department's programs, but rather a compilation of the programs of those offices that submitted inputs

  5. Energy materials coordinating committee (EMaCC). Annual technical report, fiscal year 2005

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2006-09-29

    The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further effective use of materials expertise within the Department. These functions are accomplished through the exchange of budgetary and planning information among program managers and through technical meetings/workshops on selected topics involving both DOE and major contractors. In addition, EMaCC assists in obtaining materials-related inputs for both intra- and interagency compilations. Topical subcommittees of the EMaCC are responsible for conducting seminars and otherwise facilitating information flow between DOE organizational units in materials areas of particular importance to the Department. The EMaCC Terms of Reference were recently modified and developed into a Charter that was approved on June 5, 2003. As a result of this reorganization, the existing subcommittees were disbanded and new subcommittees are being formed. The FY 2004 budget summary for DOE Materials Activities is presented on page 8. The distribution of these funds between DOE laboratories, private industry, academia and other organizations is presented in tabular form on page 10. Following the budget summary is a set of detailed program descriptions for the FY 2004 DOE Materials activities. These descriptions are presented according to the organizational structure of the Department. A mission statement, a budget summary listing the project titles and FY 2004 funding, and detailed project summaries are presented for each Assistant Secretary office, the Office of Science, and the National Nuclear Security Administration. The project summaries also provide DOE, laboratory, academic and industrial contacts for each project, as appropriate.

  6. Resurgence of Neisseria meningitidis serogroup W ST-11 (cc11) in Madagascar, 2015-2016.

    Science.gov (United States)

    Rasoanandrasana, Saïda; Raberahona, Mihaja; Milenkov, Milen; Rakotomahefa Narison, Mbolanirina Lala; Ranaivo Rabetokotany, Felana; Rakotovao, Luc; Randria, Mamy Jean de Dieu; Hong, Eva; Paranhos-Baccalà, Glaucia; Taha, Muhamed-Kheir; Rakoto-Andrianarivelo, Mala

    2017-02-01

    The resurgence of invasive meningococcal disease caused by Neisseria meningitidis serogroup W with sequence type ST-11 (cc11) was observed in Madagascar in 2015-2016. Three cases were investigated in this study. Molecular characterization of the strains suggests the local transmission of a single genotype that may have been circulating for years. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. Energy Materials Coordinating Committee (EMaCC). Annual technical report, fiscal year 1983

    Energy Technology Data Exchange (ETDEWEB)

    None

    1984-03-01

    The following text briefly describes the materials research programs of the Department of Energy. It is organized by office and organizational charts are provided to allow easy identification of the materials research programs of each office. These program descriptions have been prepared from inputs submitted by many different EMaCC members. This report is not a comprehensive summary of the Department's programs, but rather a compilation of the programs of those offices that submitted inputs.

  8. Optoelectronic properties of CC2TA towards a good TADF material

    Science.gov (United States)

    Mishra, Ashok Kumar

    2018-05-01

    2,4-bis{f3-(9H-carbazol-9-yl)-9H-carbazol-9-yl}-6-phenyl-1,3,5-triazine (CC2TA) is a triazine derivatives in which the acceptor phenyltriazine unit is used as the central skeleton and donor bicarbazole units are bonded to both ends of the skeleton. Molecular orbital calculations exhibit that the HOMO and LUMO are locally allocated chiefly in the bicarbazole and phenyltriazine units, respectively. There are a class of organic molecules and polymers which exhibit semiconductor behavior because of nearly free conjugate π-electrons. Hopping of these electrons in molecules forms different excited singlet and triplet states named as excitons. Some of these organic molecules can be set to emit photons by triplet-singlet excitonic transition via a process called Thermally Activated Delayed Fluorescence (TADF) which is exploited for designing the Organic Light Emitting diode (OLED.) CC2TA is one of these reported noble metal-free TADF molecules which offers unique opto electronic properties arising from the reverse intersystem crossing between the lowest singlet (S) and triplet (T) excited states. Its ability to harvest triplet excitons for fluorescence through facilitated reverse intersystem crossing (T→S) could directly impact their properties and performances, which is attractive for a wide variety of low-cost optoelectronic device. In the present study, the CC2TA compounds have been taken up for the investigation of various optoelectronic properties including the thermally activated delayed fluorescence (TADF) by using the Koopmans Method and Density Functional Theory. The present study discusses the utility of the CC2TA organic semiconductor as a suitable TADF material essential for developing an efficient Organic Light Emitting Diode (OLED).

  9. Energy Materials Coordinating Committee (EMaCC), Fiscal year 1992. Annual technical report

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The DOE EMaCC serves to coordinate the department`s materials programs and to further effective use of materials expertise within the department. This document presents summaries of budgets and of research projects, arranged according to the offices of energy efficiency and renewable energy, energy research, environmental restoration and waste management, nuclear energy, civilian radioactive waste management, defense, and fossil energy. A directory and a keyword index are included.

  10. The Stop Transmission of Polio Data Management (STOP DM) assignment and its role in polio eradication and immunization data improvement in Africa

    OpenAIRE

    Benke, Amalia; Williams, Alford Joseph; MacNeil, Adam

    2017-01-01

    The availability and use of high quality immunization and surveillance data are crucial for monitoring all components of the Global Polio Eradication Program (GPEI). The Stop Transmission of Polio (STOP) program was initiated in 1999 to train and mobilize human resources to provide technical support to polio endemic and at-risk countries and in 2002 the STOP data management (STOP DM) deployment was created to provide capacity development in the area of data management for immunization and sur...

  11. A compendium of the data used with the SYVAC3-CC3 system model

    International Nuclear Information System (INIS)

    Szekely, J.G.; Stephens, M.E.; Witzke, K.H.; Melnyk, T.W.; LeNeveu, D.M.; McConnell, D.B.; Goodwin, B.W.

    1994-12-01

    AECL is evaluating a concept for disposing of nuclear fuel waste from Canada's CANDU reactors deep in plutonic rock of the Canadian Shield. As part of this evaluation, AECL has developed models of the physicals, chemical, geological and biological processes that could occur in a sealed accessible environment over thousands of years. The mathematical models of the transport of radionuclides and toxic chemicals from nuclear fuel waste to the environment are incorporated into a computer model named the SYstems Variability Analysis Code, generation 3, and Canadian Concept model, generation 3 (SYVAC3-CC3). This report reproduces the data in the master database used by SYVAC3-CC3 for the postclosure assessment of deep laboratory and field studies conducted by AECL Research over the past fifteen years, including the investigations at an Underground Research Laboratory excavated to a depth of 450 meters in a large granitic batholith within the Whiteshell Research area near Lac du Bonnet, Manitoba; conceptual engineering studies; detailed analyses of specific features, events and processes; and published literature. The data represent characteristics of a hypothetical vault, certain geological characteristics of the Whiteshell Research area, and a general surface environment with a human population living a rural lifestyle on a portion of the Canadian Shield in central Canada. The data are stored in a master database, which is used with a suite of computer programs to create the input data files used by SYVAC3-CC3. (author). 19 refs., 11 tabs., 2 figs

  12. B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292

    Directory of Open Access Journals (Sweden)

    Arnason JE

    2014-01-01

    Full Text Available Jon E Arnason,1 Jennifer R Brown21Beth Israel Deaconess Medical Center, 2CLL Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USAAbstract: Chronic lymphocytic leukemia (CLL is the most common adult leukemia. The current treatment paradigm involves the use of chemoimmunotherapy, when patients develop an indication for therapy. With this strategy, a majority of patients will obtain a remission, though cure remains elusive. While treatable, the majority of CLL patients will die of complications of their disease. Recent advances in the understanding of the importance of the B cell receptor (BCR pathway in CLL have led to the development of a number of agents targeting this pathway. In this review, we discuss recent developments in the targeting of the BCR pathway, with a focus on CC-292. CC-292 covalently binds to Bruton's tyrosine kinase, a key mediator of BCR signaling, and has demonstrated preclinical and clinical activity in CLL, with acceptable tolerability. Based on the success of CC-292 and other inhibitors of the BCR pathway, these agents are being investigated in combination with standard therapy, with the hope that they will increase the depth and length of response, without significant toxicity.Keywords: Bruton's tyrosine kinase inhibitor, ibrutinib

  13. Discovery of the doubly charmed baryon $\\Xi_{cc}^{++}$ at LHCb

    CERN Document Server

    Spradlin, Patrick

    2017-01-01

    The LHCb collaboration announced the first observation of the doubly charmed baryon $\\Xi_{cc}^{++}$, which was discovered decaying to a $\\Lambda_{c}^{+}K^{-}\\pi^{+}\\pi^{+}$ final state. A highly significant structure is found in the $\\Lambda_{c}^{+}K^{-}\\pi^{+}\\pi^{+}$ mass spectrum in proton-proton collision data collected by the LHCb experiment at center-of-mass energies of 13 TeV and 8 TeV. The peak contains $313 \\pm 33$ decays in the 13 TeV sample and $113 \\pm 21$ decays in the 8 TeV, with local significances in excess of $12\\sigma$ and $7\\sigma$ respectively. The narrow structure has a width that is consistent with experimental resolution, and its properties are consistent with those of a weakly decaying state and inconsistent with those of a strongly decaying state. The difference between the masses of the structure, identified as $\\Xi_{cc}^{++}$, and the $\\Lambda_{c}^{+}$ baryon is $1334.94 \\pm 0.72(\\mbox{stat.}) \\pm 0.27(\\mbox{syst.})\\,\\mbox{MeV}/c^{2}$, and the mass of the $\\Xi_{cc}^{++}$ baryon ...

  14. Selective degradation of the recalcitrant cell wall of Scenedesmus quadricauda CASA CC202.

    Science.gov (United States)

    Reshma, Ragini; Arumugam, Muthu

    2017-10-01

    An eco-friendly cell wall digestion strategy was developed to enhance the availability of nutritionally important bio molecules of edible microalgae and exploit them for cloning, transformation, and expression of therapeutic proteins. Microalgae are the source for many nutritionally important bioactive compounds and potential drugs. Even though edible microalgae are rich in nutraceutical, bioavailability of all these molecules is very less due to their rigid recalcitrant cell wall. For example, the cell wall of Scenedesmus quadricauda CASA CC202 is made up of three layers comprising of rigid outer pectin and inner cellulosic layer separated by a thin middle layer. In the present investigation, a comprehensive method has been developed for the selective degradation of S. quadricauda CASA CC202 cell wall, by employing both mechanical and enzymatic treatments. The efficiency of cell wall removal was evaluated by measuring total reducing sugar (TRS), tannic acid-ferric chloride staining, calcoflour white staining, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) analysis. It was confirmed that the yield of TRS increased from 129.82 mg/g in 14 h from pectinase treatment alone to 352.44 mg/g by combined sonication and enzymatic treatment within 12 h. As a result, the combination method was found to be effective for the selective degradation of S. quadricauda CASA CC202 cell wall. This study will form a base for our future works, where this will help to enhance the digestibility and availability of nutraceutically important proteins.

  15. A DAQ system for CAMAC controller CC/NET using DAQ-Middleware

    International Nuclear Information System (INIS)

    Inoue, E; Yasu, Y; Nakayoshi, K; Sendai, H

    2010-01-01

    DAQ-Middleware is a framework for the DAQ system which is based on RT-Middleware (Robot Technology Middleware) and dedicated to making DAQ systems. DAQ-Middleware has come into use as a one of the DAQ system framework for the next generation Particle Physics experiment at KEK in recent years. DAQ-Middleware comprises DAQ-Components with all necessary basic functions of the DAQ and is easily extensible. So, using DAQ-Middleware, you are able to construct easily your own DAQ system by combining these components. As an example, we have developed a DAQ system for a CC/NET [1] using DAQ-Middleware by the addition of GUI part and CAMAC readout part. The CC/NET, the CAMAC controller was developed to accomplish high speed read-out of CAMAC data. The basic design concept of CC/NET is to realize data taking through networks. So, it is consistent with the DAQ-Middleware concept. We show how it is convenient to use DAQ-Middleware.

  16. Boron-Based Catalysts for C-C Bond-Formation Reactions.

    Science.gov (United States)

    Rao, Bin; Kinjo, Rei

    2018-05-02

    Because the construction of the C-C bond is one of the most significant reactions in organic chemistry, the development of an efficient strategy has attracted much attention throughout the synthetic community. Among various protocols to form C-C bonds, organoboron compounds are not just limited to stoichiometric reagents, but have also made great achievements as catalysts because of the easy modification of the electronic and steric impacts on the boron center. This review presents recent developments of boron-based catalysts applied in the field of C-C bond-formation reactions, which are classified into four kinds on the basis of the type of boron catalyst: 1) highly Lewis acidic borane, B(C 6 F 5 ) 3 ; 2) organoboron acids, RB(OH) 2 , and their ester derivatives; 3) borenium ions, (R 2 BL)X; and 4) other miscellaneous kinds. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Is one-stop surgery for carpal tunnel syndrome safe?

    DEFF Research Database (Denmark)

    Jørgensen, Louise Møller; Piil, Karin; Bashir, Asma

    2017-01-01

    OBJECTIVES: The aim of this study was to evaluate one-stop surgery (OSS) for carpal tunnel syndrome (CTS) regarding symptom relief and patient satisfaction. OSS in our setting means only one visit to the hospital for surgery and no hospital appointments for preassessment or follow-up. We hypothes...

  18. What You Can Do to Stop the Flu

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Flu What You Can Do to Stop the Flu Past Issues / Fall 2009 Table of Contents To ... Health and Human Services: http://flu.gov NIH Flu Research to Results Scientists at the National Institute ...

  19. Inferring Stop-Locations from WiFi.

    Directory of Open Access Journals (Sweden)

    David Kofoed Wind

    Full Text Available Human mobility patterns are inherently complex. In terms of understanding these patterns, the process of converting raw data into series of stop-locations and transitions is an important first step which greatly reduces the volume of data, thus simplifying the subsequent analyses. Previous research into the mobility of individuals has focused on inferring 'stop locations' (places of stationarity from GPS or CDR data, or on detection of state (static/active. In this paper we bridge the gap between the two approaches: we introduce methods for detecting both mobility state and stop-locations. In addition, our methods are based exclusively on WiFi data. We study two months of WiFi data collected every two minutes by a smartphone, and infer stop-locations in the form of labelled time-intervals. For this purpose, we investigate two algorithms, both of which scale to large datasets: a greedy approach to select the most important routers and one which uses a density-based clustering algorithm to detect router fingerprints. We validate our results using participants' GPS data as well as ground truth data collected during a two month period.

  20. Detector for recoil nuclei stopping in the spark chamber gas

    International Nuclear Information System (INIS)

    Aleksanyan, A.S.; Asatiani, T.L.; Ivanov, V.I.; Mkrtchyan, G.G.; Pikhtelev, R.N.

    1974-01-01

    A detector consisting of the combination of a drift and a wide gap spark chambers and designed to detect recoil nuclei stopping in the spark chamber gas is described. It is shown, that by using an appropriate discrimination the detector allows to detect reliably the recoil nuclei in the presence of intensive electron and γ-quanta beams

  1. On a rational stopping rule for facilities location algorithms

    DEFF Research Database (Denmark)

    Juel, Henrik

    1984-01-01

    In the multifacility location problem, a number of new facilities are to be located so as to minimize a sum of weighted distances. Love and Yeong (1981) developed a lower bound on the optimal value for use in deciding when to stop an iterative solution procedure. The authors develop a stronger...

  2. Stopping particles in the Mont Blanc spark chamber telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Bergamasco, L; Bilokon, H; Piazzoli, B E; Mannocchi, G; Picchi, P [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Turin Univ. (Italy). Ist. di Fisica Generale)

    1982-02-01

    We present the final results on the ratio of stopping to traversing muons as measured by two spark chamber telescopes in the Mont Blanc Station, Italy, at 4300 hg/cm/sup 2/. The experimental results are in agreement with the theoretical values within the limits of the error.

  3. 32 CFR 636.30 - Stopping, standing and parking.

    Science.gov (United States)

    2010-07-01

    ... ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Fort... which obstructs traffic. (g) No driver will stand or park a vehicle, whether occupied or not, except...) Within 20 feet upon the approach to any flashing signal, a stop sign, yield sign, or traffic control...

  4. Inferring Stop-Locations from WiFi

    DEFF Research Database (Denmark)

    Wind, David Kofoed; Sapiezynski, Piotr; Furman, Magdalena Anna

    2016-01-01

    methods are based exclusively on WiFi data. We study two months of WiFi data collected every two minutes by a smartphone, and infer stop-locations in the form of labelled time-intervals. For this purpose, we investigate two algorithms, both of which scale to large datasets: a greedy approach to select...

  5. 14 CFR 25.109 - Accelerate-stop distance.

    Science.gov (United States)

    2010-01-01

    ... AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Performance § 25.109 Accelerate-stop distance. (a...) The maximum tire-to-ground wet runway braking coefficient of friction is defined as: ER18FE98.004 Where— Tire Pressure=maximum airplane operating tire pressure (psi); μt/gMAX=maximum tire-to-ground...

  6. Annihilation of antiprotons stopped in liquid hydrogen and deuterium

    International Nuclear Information System (INIS)

    Dalkarov, O.D.; Kerbikov, B.O.; Markushin, V.E.

    1976-01-01

    Detailed analysis is given of stopping antiproton annihilation in liquid hydrogen and deuterium. Connection between capture schedule and properties of bound states in nucleon-antinucleon system is established. The theoretical predictions are compared with experimental data which appeared in 1971-75

  7. Theoretical model for calculation of molecular stopping power

    International Nuclear Information System (INIS)

    Xu, Y.J.

    1984-01-01

    A modified local plasma model based on the work of Linhard-Winther, Bethe, Brown, and Walske is established. The Gordon-Kim's molecular charged density model is employed to obtain a formula to evaluate the stopping power of many useful molecular systems. The stopping power of H 2 and He gas was calculated for incident proton energy ranging from 100 KeV to 2.5 MeV. The stopping power of O 2 , N 2 , and water vapor was also calculated for incident proton energy ranging from 40 keV to 2.5 MeV. Good agreement with experimental data was obtained. A discussion of molecular effects leading to departure from Bragg's rule is presented. The equipartition rule and the effect of nuclear momentum recoiling in stopping power are also discussed in the appendix. The calculation procedure presented hopefully can easily be extended to include the most useful organic systems such as the molecules composed of carbon, nitrogen, hydrogen and oxygen which are useful in radiation protection field

  8. Assessing One-stop-shop Best Practices for South African ...

    African Journals Online (AJOL)

    One stop shop (OSS) models are an investment process that came about to create a centralised place for the voluminous documentation required in international trade between companies. Bureaucracy has proven to be a major barrier to the development of international trade, particularly in African countries that still lag ...

  9. Reasons for Starting and Stopping Electronic Cigarette Use

    Directory of Open Access Journals (Sweden)

    Jessica K. Pepper

    2014-10-01

    Full Text Available The aim of our study was to explore reasons for starting and then stopping electronic cigarette (e-cigarette use. Among a national sample of 3878 U.S. adults who reported ever trying e-cigarettes, the most common reasons for trying were curiosity (53%; because a friend or family member used, gave, or offered e-cigarettes (34%; and quitting or reducing smoking (30%. Nearly two-thirds (65% of people who started using e-cigarettes later stopped using them. Discontinuation was more common among those whose main reason for trying was not goal-oriented (e.g., curiosity than goal-oriented (e.g., quitting smoking (81% vs. 45%, p < 0.001. The most common reasons for stopping e-cigarette use were that respondents were just experimenting (49%, using e-cigarettes did not feel like smoking cigarettes (15%, and users did not like the taste (14%. Our results suggest there are two categories of e-cigarette users: those who try for goal-oriented reasons and typically continue using and those who try for non-goal-oriented reasons and then typically stop using. Research should distinguish e-cigarette experimenters from motivated users whose decisions to discontinue relate to the utility or experience of use. Depending on whether e-cigarettes prove to be effective smoking cessation tools or whether they deter cessation, public health programs may need distinct strategies to reach and influence different types of users.

  10. Reasons for starting and stopping electronic cigarette use.

    Science.gov (United States)

    Pepper, Jessica K; Ribisl, Kurt M; Emery, Sherry L; Brewer, Noel T

    2014-10-03

    The aim of our study was to explore reasons for starting and then stopping electronic cigarette (e-cigarette) use. Among a national sample of 3878 U.S. adults who reported ever trying e-cigarettes, the most common reasons for trying were curiosity (53%); because a friend or family member used, gave, or offered e-cigarettes (34%); and quitting or reducing smoking (30%). Nearly two-thirds (65%) of people who started using e-cigarettes later stopped using them. Discontinuation was more common among those whose main reason for trying was not goal-oriented (e.g., curiosity) than goal-oriented (e.g., quitting smoking) (81% vs. 45%, p reasons for stopping e-cigarette use were that respondents were just experimenting (49%), using e-cigarettes did not feel like smoking cigarettes (15%), and users did not like the taste (14%). Our results suggest there are two categories of e-cigarette users: those who try for goal-oriented reasons and typically continue using and those who try for non-goal-oriented reasons and then typically stop using. Research should distinguish e-cigarette experimenters from motivated users whose decisions to discontinue relate to the utility or experience of use. Depending on whether e-cigarettes prove to be effective smoking cessation tools or whether they deter cessation, public health programs may need distinct strategies to reach and influence different types of users.

  11. Drinking and driving behavior at stop signs and red lights.

    Science.gov (United States)

    Wan, Jingyan; Wu, Changxu; Zhang, Yiqi; Houston, Rebecca J; Chen, Chang Wen; Chanawangsa, Panya

    2017-07-01

    Alcohol is one of the principal risk factors for motor vehicle crashes. One factor that contributes to vehicle crashes is noncompliance with stop signs and red lights. The present experiment investigated the effects of alcohol and drinking patterns on driving behavior at stop signs and red lights. 28 participants participated in drinking and simulated driving sessions during which they received a moderate dose of alcohol (0.08% BAC) or a placebo. Simulated driving tasks measured participants' driving performance at stop signs and red lights in response to each dose. Results suggested that alcohol impaired the driver control of speed and direction and prolonged their simple and complex reaction time, which were exhibited by impaired speed and lateral control, longer reaction time when the lights turned yellow, and lower deceleration towards stop signs and red lights. Visual degradation may also occur under alcohol intake. It was also suggested that alcohol impaired non-binge drinkers more severely. To be specific, higher acceleration was observed in impaired non-binge drinkers. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. "STOP the Violence": FCCLA Program Tackles School Issue

    Science.gov (United States)

    Journal of Family and Consumer Sciences, 2004

    2004-01-01

    "STOP the Violence--Students Taking on Prevention" is a program designed to involve students and address school violence at its core from the peer-to- peer perspective. Developed by members of the Family, Career and Community Leaders of America (FCCLA), the program empowers young persons to recognize, report, and reduce the potential for youth…

  13. A Connection between Singular Stochastic Control and Optimal Stopping

    International Nuclear Information System (INIS)

    Espen Benth, Fred; Reikvam, Kristin

    2003-01-01

    We show that the value function of a singular stochastic control problem is equal to the integral of the value function of an associated optimal stopping problem. The connection is proved for a general class of diffusions using the method of viscosity solutions

  14. Stopping Power of Solid Argon for Helium Ions

    DEFF Research Database (Denmark)

    Besenbacher, F.; Bøttiger, Jørgen; Grauersen, O.

    1981-01-01

    By means of the Rutherford-backscattering method, the stopping cross section of solid argon has been measured for 0.5–3 MeV helium ions to an accuracy of not, vert, similar3%. The results agree within the experimental accuracies with our earlier measurements for gaseous argon over the energy region...

  15. Negative Thought Stopping. A Key to Performance Enhancement.

    Science.gov (United States)

    Ziegler, Susan G.

    1987-01-01

    The effects of mental training on skill acquisition and performance is currently emphasized in the study of sport psychology and motor learning. This article provides the teacher and coach with general guidelines for understanding and incorporating negative thought stopping training into athletic programs. (MT)

  16. Stop the Tears of Drug and Alcohol Abuse

    Science.gov (United States)

    Shimon, Jane; Gibson, Terry-Ann; Spear, Caile

    2009-01-01

    Objectives: By participating in this Stop the Tears teaching strategy, students will be able to: (1) analyze how alcohol and drug abuse could affect their lives as well as the lives of their friends and family and, (2) create a media message, such as a poster, pamphlet, poem, or song, in which alcohol and drug prevention is advocated specific to…

  17. Impact-parameter-dependent electronic stopping of swift ions

    NARCIS (Netherlands)

    Schinner, A.; Sigmund, P.

    2010-01-01

    A computational scheme has been developed to estimate the mean electronic energy loss of an incident swift ion on an atomic target as a function of the impact parameter between the moving nuclei. The theoretical basis is binary stopping theory. In order to extract impact-parameter dependencies it

  18. Dose calculations using MARS for Bremsstrahlung beam stops and collimators in APS beamline stations.

    Energy Technology Data Exchange (ETDEWEB)

    Dooling, J.; Accelerator Systems Division (APS)

    2010-11-01

    The Monte Carlo radiation transport code MARS is used to model the generation of gas bremsstrahlung (GB) radiation from 7-GeV electrons which scatter from residual gas atoms in undulator straight sections within the Advanced Photon Source (APS) storage ring. Additionally, MARS is employed to model the interactions of the GB radiation with components along the x-ray beamlines and then determine the expected radiation dose-rates that result. In this manner, MARS can be used to assess the adequacy of existing shielding or the specifications for new shielding when required. The GB radiation generated in the 'thin-target' of an ID straight section will consist only of photons in a 1/E-distribution up to the full energy of the stored electron beam. Using this analytical model, the predicted GB power for a typical APS 15.38-m insertion device (ID) straight section is 4.59 x 10{sup -7} W/nTorr/mA, assuming a background gas composed of air (Z{sub eff} = 7.31) at room temperature (293K). The total GB power provides a useful benchmark for comparisons between analytical and numerical approaches. We find good agreement between MARS and analytical estimates for total GB power. The extended straight section 'target' creates a radial profile of GB, which is highly peaked centered on the electron beam. The GB distribution reflects the size of the electron beam that creates the radiation. Optimizing the performance of MARS in terms of CPU time per incident trajectory requires the use of a relatively short, high-density gas target (air); in this report, the target density is {rho}L = 2.89 x 10{sup -2} g/cm{sup 2} over a length of 24 cm. MARS results are compared with the contact dose levels reported in TB-20, which used EGS4 for radiation transport simulations. Maximum dose-rates in 1 cc of tissue phantom form the initial basis for comparison. MARS and EGS4 results are approximately the same for maximum 1-cc dose-rates and attenuation in the photon

  19. Stashing the stops in multijet events at the LHC

    Science.gov (United States)

    Diglio, Sara; Feligioni, Lorenzo; Moultaka, Gilbert

    2017-09-01

    While the presence of a light stop is increasingly disfavored by the experimental limits set on R-parity conserving scenarios, the naturalness of supersymmetry could still be safely concealed in the more challenging final states predicted by the existence of non-null R-parity violating couplings. Although R-parity violating signatures are extensively looked for at the Large Hadron Collider, these searches mostly assume 100% branching ratios for the direct decays of supersymmetric particles into Standard Model ones. In this paper we scrutinize the implications of relaxing this assumption by focusing on one motivated scenario where the lightest stop is heavier than a chargino and a neutralino. Considering a class of R-parity baryon number violating couplings, we show on general grounds that while the direct decay of the stop into Standard Model particles is dominant for large values of these couplings, smaller values give rise, instead, to the dominance of a plethora of longer decay chains and richer final states that have been so far barely analyzed at the LHC, thus weakening the impact of the present experimental stop mass limits. We characterize the case for R-parity baryon number violating couplings in the 10-7-10-1 range, in two different benchmark points scenarios within the model-independent setting of the low-energy phenomenological Minimal Supersymmetric Standard Model. We identify the different relevant experimental signatures from stop pair production and decays, estimate the corresponding proton-proton cross sections at √{s }=14 TeV and discuss signal versus background issues.

  20. Coherent resonance stop bands in alternating gradient beam transport

    Science.gov (United States)

    Ito, K.; Okamoto, H.; Tokashiki, Y.; Fukushima, K.

    2017-06-01

    An extensive experimental study is performed to confirm fundamental resonance bands of an intense hadron beam propagating through an alternating gradient linear transport channel. The present work focuses on the most common lattice geometry called "FODO" or "doublet" that consists of two quadrupoles of opposite polarities. The tabletop ion-trap system "S-POD" (Simulator of Particle Orbit Dynamics) developed at Hiroshima University is employed to clarify the parameter-dependence of coherent beam instability. S-POD can provide a non-neutral plasma physically equivalent to a charged-particle beam in a periodic focusing potential. In contrast with conventional experimental approaches relying on large-scale machines, it is straightforward in S-POD to control the doublet geometry characterized by the quadrupole filling factor and drift-space ratio. We verify that the resonance feature does not essentially change depending on these geometric factors. A few clear stop bands of low-order resonances always appear in the same pattern as previously found with the sinusoidal focusing model. All stop bands become widened and shift to the higher-tune side as the beam density is increased. In the space-charge-dominated regime, the most dangerous stop band is located at the bare betatron phase advance slightly above 90 degrees. Experimental data from S-POD suggest that this severe resonance is driven mainly by the linear self-field potential rather than by nonlinear external imperfections and, therefore, unavoidable at high beam density. The instability of the third-order coherent mode generates relatively weak but noticeable stop bands near the phase advances of 60 and 120 degrees. The latter sextupole stop band is considerably enhanced by lattice imperfections. In a strongly asymmetric focusing channel, extra attention may have to be paid to some coupling resonance lines induced by the Coulomb potential. Our interpretations of experimental data are supported by theoretical

  1. Integration of Services for Victims of Child Sexual Abuse at the University Teaching Hospital One-Stop Centre

    Directory of Open Access Journals (Sweden)

    Elwyn Chomba

    2010-01-01

    Full Text Available Objective. To improve care of sexually abused children by establishment of a “One Stop Centre” at the University Teaching Hospital. Methodology. Prior to opening of the One Stop Centre, a management team comprising of clinical departmental heads and a technical group of professionals (health workers, police, psychosocial counselors lawyers and media were put in place. The team evaluated and identified gaps and weaknesses on the management of sexually abused children prevailing in Zambia. A manual was produced which would be used to train all professionals manning a One Stop Centre. A team of consultants from abroad were identified to offer need based training activities and a database was developed. Results. A multidisciplinary team comprising of health workers, police and psychosocial counselors now man the centre. The centre is assisted by lawyers as and when required. UTH is offering training to other areas of the country to establish similar services by using a Trainer of Trainers model. A comprehensive database has been established for Lusaka province. Conclusion. For establishment of a One Stop Centre, there needs to be a core group comprising of managers as well as a technical team committed to the management and protection of sexually abused children.

  2. Catalytic diastereoselective tandem conjugate addition-elimination reaction of Morita-Baylis-Hillman C adducts by C-C bond cleavage

    KAUST Repository

    Yang, Wenguo

    2012-02-08

    Through the cleavage of the C-C bond, the first catalytic tandem conjugate addition-elimination reaction of Morita-Baylis-Hillman C adducts has been presented. Various S N2′-like C-, S-, and P-allylic compounds could be obtained with exclusive E configuration in good to excellent yields. The Michael product could also be easily prepared by tuning the β-C-substituent group of the α-methylene ester under the same reaction conditions. Calculated relative energies of various transition states by DFT methods strongly support the observed chemoselectivity and diastereoselectivity. © 2012 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.

  3. Psychosocial interventions for supporting women to stop smoking in pregnancy

    Science.gov (United States)

    Chamberlain, Catherine; O’Mara-Eves, Alison; Oliver, Sandy; Caird, Jenny R; Perlen, Susan M; Eades, Sandra J; Thomas, James

    2014-01-01

    1.15, 95% CI 0.86 to 1.53). In studies comparing counselling and usual care (the largest comparison), it was unclear whether interventions prevented smoking relapse among women who had stopped smoking spontaneously in early pregnancy (eight studies; average RR 1.06, 95% CI 0.93 to 1.21). However, a clear effect was seen in smoking abstinence at zero to five months postpartum (10 studies; average RR 1.76, 95% CI 1.05 to 2.95), a borderline effect at six to 11 months (six studies; average RR 1.33, 95% CI 1.00 to 1.77), and a significant effect at 12 to 17 months (two studies, average RR 2.20, 95% CI 1.23 to 3.96), but not in the longer term. In other comparisons, the effect was not significantly different from the null effect for most secondary outcomes, but sample sizes were small. Incentive-based interventions had the largest effect size compared with a less intensive intervention (one study; RR 3.64, 95% CI 1.84 to 7.23) and an alternative intervention (one study; RR 4.05, 95% CI 1.48 to 11.11). Feedback interventions demonstrated a significant effect only when compared with usual care and provided in conjunction with other strategies, such as counselling (two studies; average RR 4.39, 95% CI 1.89 to 10.21), but the effect was unclear when compared with a less intensive intervention (two studies; average RR 1.19, 95% CI 0.45 to 3.12). The effect of health education was unclear when compared with usual care (three studies; average RR 1.51, 95% CI 0.64 to 3.59) or less intensive interventions (two studies; average RR 1.50, 95% CI 0.97 to 2.31). Social support interventions appeared effective when provided by peers (five studies; average RR 1.49, 95% CI 1.01 to 2.19), but the effect was unclear in a single trial of support provided by partners. The effects were mixed where the smoking interventions were provided as part of broader interventions to improve maternal health, rather than targeted smoking cessation interventions. Subgroup analyses on primary outcome for

  4. The Stop Transmission of Polio Data Management (STOP DM) assignment and its role in polio eradication and immunization data improvement in Africa.

    Science.gov (United States)

    Benke, Amalia; Williams, Alford Joseph; MacNeil, Adam

    2017-01-01

    The availability and use of high quality immunization and surveillance data are crucial for monitoring all components of the Global Polio Eradication Program (GPEI). The Stop Transmission of Polio (STOP) program was initiated in 1999 to train and mobilize human resources to provide technical support to polio endemic and at-risk countries and in 2002 the STOP data management (STOP DM) deployment was created to provide capacity development in the area of data management for immunization and surveillance data for these countries. Since 2002, Africa has received the majority of support from the STOP DM program, with almost 80% of assignments being placed in African countries. The STOP DM program has played a valuable role in improving the quality and use of data for the GPEI and has increasingly supported other immunization program data needs. In this report we provide an overview of the history, current status, and future of the STOP DM program, with a specific focus on the African continent.

  5. Induction of heat-labile sites in DNA of mammalian cells by the antitumor alkylating drug CC-1065

    International Nuclear Information System (INIS)

    Zsido, T.J.; Woynarowski, J.M.; Baker, R.M.; Gawron, L.S.; Beerman, T.A.

    1991-01-01

    CC-1065 is a very potent antitumor antibiotic capable of covalent and noncovalent binding to the minor groove of naked DNA. Upon thermal treatment, covalent adducts formed between CC-1065 and DNA generate strand break. The authors have shown that this molecular damage can be detected following CC-1065 treatment of mammalian whole cells. Using alkaline sucrose gradient analysis, They observe thermally induced breakage of [ 14 C]thymidine-prelabeled DNA from drug-treated African green monkey kidney BSC-1 cells. Very little damage to cellular DNA by CC-1065 can be detected without first heating the drug-treated samples. CC-1065 can also generate heat-labile sites within DNA during cell lysis and heating, subsequent to the exposure of cells to drug, suggesting that a pool of free and noncovalently bound drug is available for posttreatment adduct formation. This effect was controlled for by mixing [ 3 H]thymidine-labeled untreated cells with the [ 14 C]thymidine-labeled drug-treated samples. The lowest drug dose at which heat-labile sites were detected was 3 nM CC-1065 (3 single-stranded breaks/10 6 base pairs). This concentration reduced survival of BSC-1 cells to 0.1% in cytotoxicity assays. The generation of CC-1065-induced lesions in cellular DNA is time dependent (the frequency of lesions caused by a 60 nM treatment reaching a plateau at 2 h) and is not readily reversible. The results of this study demonstrate that CC-1065 does generate heat-labile sites with the cellular DNA of intact cells and suggest that a mechanism of cytotoxic action of CC-1065 involves formation of covalent adducts to DNA

  6. Introduction to Stopping Time in Stochastic Finance Theory. Part II

    Directory of Open Access Journals (Sweden)

    Jaeger Peter

    2017-12-01

    Full Text Available We start proceeding with the stopping time theory in discrete time with the help of the Mizar system [1], [4]. We prove, that the expression for two stopping times k1 and k2 not always implies a stopping time (k1 + k2 (see Theorem 6 in this paper. If you want to get a stopping time, you have to cut the function e.g. (k1 + k2 ⋂ T (see [2, p. 283 Remark 6.14]. Next we introduce the stopping time in continuous time. We are focused on the intervals [0, r] where r ∈ ℝ. We prove, that for I = [0, r] or I = [0,+∞[ the set {A ⋂ I : A ∈ Borel-Sets} is a σ-algebra of I (see Definition 6 in this paper, and more general given in [3, p.12 1.8e]. The interval I can be considered as a timeline from now to some point in the future. This set is necessary to define our next lemma. We prove the existence of the σ-algebra of the τ -past, where τ is a stopping time (see Definition 11 in this paper and [6, p.187, Definition 9.19]. If τ1 and τ2 are stopping times with τ1 is smaller or equal than τ2 we can prove, that the σ-algebra of the τ1-past is a subset of the σ-algebra of the τ2-past (see Theorem 9 in this paper and [6, p.187 Lemma 9.21]. Suppose, that you want to use Lemma 9.21 with some events, that never occur, see as a comparison the paper [5] and the example for ST(1={+∞} in the Summary. We don’t have the element +1 in our above-mentioned time intervals [0, r[ and [0,+1[. This is only possible if we construct a new σ-algebra on ℝ {−∞,+∞}. This construction is similar to the Borel-Sets and we call this σ-algebra extended Borel sets (see Definition 13 in this paper and [3, p. 21]. It can be proved, that {+∞} is an Element of extended Borel sets (see Theorem 21 in this paper. Now we use the interval [0,+∞] as a basis. We construct a σ-algebra on [0,+∞] similar to the book ([3, p. 12 18e], see Definition 18 in this paper, and call it extended Borel subsets. We prove for stopping times with this given σ-algebra, that

  7. Romantic Love Is Associated with Enhanced Inhibitory Control in an Emotional Stop-Signal Task

    Science.gov (United States)

    Song, Sensen; Zou, Zhiling; Song, Hongwen; Wang, Yongming; d’Oleire Uquillas, Federico; Wang, Huijun; Chen, Hong

    2016-01-01

    Purpose: This study explored whether romantic lovers differ in emotion-related inhibitory control capacity from those who are single. Methods: 88 healthy undergraduate college students participated in the study. Half were currently in love and in a romantic relationship (love group, LG), and half were single and had never been in a romantic relationship (single group, SG). Based on duration of romantic relationship (i.e., love duration), the LG were further divided into two subgroups: “early stage love” and “longer periods of love”. All participants completed an emotional Stop Signal Task, consisting of a variety of human face stimuli displaying either sad or neutral affect. Results: Results found that relative to SG, lovers showed greater inhibitory control [shorter stop-signal reaction time (SSRT)] during negative emotion condition trials. Furthermore, in early stages of love, SSRT for negative emotion condition trials was significantly shorter compared to that in “longer periods of love” or SG individuals, with no significant differences between the two latter groups. Conclusion: Compared with individuals who were single, early stage lovers showed greater capacity for inhibiting action during presentation of negative emotional stimuli. Within a greater social context, greater inhibitory control capacity during early stages of love may be related to the successful formation of romantic relationships, particularly to the ability to persevere in goal-directed action despite negative emotional contexts such as that of sadness. PMID:27826260

  8. Romantic love is associated with enhanced inhibitory control in an emotional stop-signal task

    Directory of Open Access Journals (Sweden)

    Sensen Song

    2016-10-01

    Full Text Available Purpose: This study explored whether romantic lovers differ in emotion-related inhibitory control capacity from those who are single. Methods: 88 healthy undergraduate college students participated in the study. Half were currently in love and in a romantic relationship (love group, LG, and half were single and had never been in a romantic relationship (single group, SG. Based on duration of romantic relationship (i.e., love duration, the LG were further divided into two subgroups: early stage love and longer periods of love. All participants completed an emotional Stop Signal Task (eSST, which consisted of a variety of human face stimuli representing sadness (a negative emotion, as well as neutral emotions. Results: Results found that relative to SG, lovers showed greater inhibitory control [shorter stop-signal reaction time (SSRT] during negative emotion condition trials. Furthermore, in early stages of love, SSRT for negative emotion condition trials was significantly shorter compared to that in longer periods of love or SG individuals, with no significant differences between the latter two groups. Conclusions: Compared with individuals who were single, early-stage lovers showed greater capacity for inhibiting action during presentation of negative emotional stimuli. Within a greater social context, greater inhibitory control capacity during early stages of love may be related to the successful formation of romantic relationships, particularly to the ability to persevere in goal-directed action despite negative emotional contexts such as that of sadness.

  9. Economical impact of the BIG/CC technology use on the sugar cane industry

    Energy Technology Data Exchange (ETDEWEB)

    Queiroz, L.C. de; Nascimento, M.J.M. do [Brascep Engenharia Ltda., Rio de Janeiro (Brazil)

    1993-12-31

    The use of biomass as primary fuel for power and steam production using modern conversion technology such as the Biomass Integrated Gas Turbine/Combined Cycle (BIG/CC) has both technical and commercial potential. Brazil is implementing a BIG/CC Demonstration Plant to burn wood from eucalyptus short rotation forest and to test sugar cane bagasse as feedstock. The purpose of this project is to demonstrate the commercial viability of using biomass as a feedstock for power generation, its suitability for applications in developing countries, and the possibilities it offers for commercial activities in regions which currently have a low level of economic activities. The purpose of this paper is to show the potential applicability of this technology in the sugar cane industries of Developing Countries such as Brazil. The same quantity of sugar cane already processed in each sugar mill can produce sizable quantities of electric power at competitive costs, in addition to the traditional products -- sugar and/or ethanol, which will cause an economical impact, duplicating the revenue of these industries. The application of the BIG/CC technology in the Sugar Cane Industry may lead to the following scenario in developing countries: (1) power shall be produced at very competitive prices by specialized private firms associated with sugar mills; (2) plant sizes will be smaller -- 15 to 100 MW -- when based on biomass, a compared to large fossil fuel plants now prevailing; (3) ethanol and sugar production costs will be reduced due to more efficient and economical processes and due to the additional revenue from power production; (4) becoming more competitive with gasoline, ethanol production tends to increase, which will influence the automobile industry and improve the quality of life in big cities.

  10. GENXICC: A generator for hadronic production of the double heavy baryons ΞccΞcc, ΞbcΞbc and ΞbbΞbb

    Science.gov (United States)

    Chang, Chao-Hsi; Wang, Jian-Xiong; Wu, Xing-Gang

    2007-09-01

    We write down a generator program for the hadronic production of the double-heavy baryons Ξ, Ξ and Ξ according to relevant publications. We name it as GENXICC and we test it by comparing its numerical results with those in references. It is written in a PYTHIA-compatible format and it can be easily implemented into PYTHIA. GENXICC is also written in modularization manner, with make, a GNU C compiler, one may apply the generator to various situations or experimental environments very conveniently. Program summaryProgram title:GENXICC Catalogue identifier:ADZJ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADZJ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions:Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.:99 252 No. of bytes in distributed program, including test data, etc.:1 432 846 Distribution format:tar.gz Programming language:FORTRAN77/90 Computer:Any LINUX based on PC with FORTRAN77 or FORTRAN90 and GNU C compiler installed Operating systems:LINUX RAM:About 2.0 MB Classification:11.2 Nature of problem:Hadronic production of a double-heavy baryons: Ξ, Ξ and Ξ. Solution method:The production of the double-heavy baryons is realized by producing a binding double-heavy diquark either (QQ)[3]3¯,6 ( Q,Q=b,c) or (QQ)[1]3¯,6, which is in color anti-triplet 3¯ or color sextuplet 6 and in S-wave triplet or singlet configuration, respectively, and then by absorbing a proper light quark non-perturbatively. For the production of the various double-heavy baryons Ξ, Ξ and Ξ, the 'gluon-gluon fusion' mechanism, being the most important, is written precisely in the generator, but two additional mechanisms, i.e. the 'gluon-charm collision' and the 'charm-charm collision' ones, only for Ξ ( Ξcc+ or Ξcc++) are written. Furthermore, all the mechanisms are treated consistently within the general-mass flavor

  11. Measurement of the Barkas effect around the stopping-power maximum for light and heavy targets

    International Nuclear Information System (INIS)

    Moeller, S.P.; Knudsen, H.; Mikkelsen, U.; Paludan, K.; Morenzoni, E.

    1997-01-01

    The first direct measurements of antiproton stopping powers around the stopping power maximum are presented. The LEAR antiproton-beam of 5.9 MeV is degraded to 50-700 keV, and the energy-loss is found by measuring the antiproton velocity before and after the target. The antiproton stopping powers of Si and Au are found to be reduced by 30 and 40% near the electronic stopping power maximum as compared to the equivalent proton stopping power. The Barkas effect, that is the stopping power difference between protons and antiprotons, is extracted and compared to theoretical estimates. (orig.)

  12. Enhancement of the oxidation resistance of carbon fibres in C/C composites via surface treatments

    Energy Technology Data Exchange (ETDEWEB)

    Labruquere, S.; Pailler, R.; Naslain, R. [Bordeaux Univ., Pessac (France). Lab. des Composites Thermostructuraux; Desbat, B. [Lab. de Spectroscopie Moleculaire et Cristalline, Univ. of Bordeaux, Talence (France)

    1997-12-31

    Carbon-carbon (C/C) composites are commonly used in rockets and braking systems. However, the carbon reacts with oxygen, burning away rapidly at temperatures as low as 450 C. This work deals with the protection of carbon fibres from oxidation between 600 and 1000 C. Two kinds of methods were investigated to protect carbon fibres: (i) surface treatment with aqueous solutions (e.g. of H3PO4) and (ii) chemical vapour deposition (CVD) of SiC coatings. Oxidation resistance of the as treated preforms was studied under dry air atmosphere. (orig.) 2 refs.

  13. An Erbium-Based Bifuctional Heterogeneous Catalyst: A Cooperative Route Towards C-C Bond Formation

    Directory of Open Access Journals (Sweden)

    Manuela Oliverio

    2014-07-01

    Full Text Available Heterogeneous bifuctional catalysts are multifunctional synthetic catalysts enabling efficient organic transformations by exploiting two opposite functionalities without mutual destruction. In this paper we report the first Er(III-based metallorganic heterogeneous catalyst, synthesized by post-calcination MW-assisted grafting and modification of the natural aminoacid L-cysteine. The natural acid–base distance between sites was maintained to assure the cooperation. The applicability of this new bifunctional heterogeneous catalyst to C-C bond formation and the supposed mechanisms of action are discussed as well.

  14. Radially excited state masses and decay constants of cc¯

    International Nuclear Information System (INIS)

    Kher, Virendrasinh H.; Devlani, Nayneshkumar B.; Rai, Ajay Kumar

    2015-01-01

    The charmonia have gained considerable theoretical interest due to many new states being discovered experimentally. Many theoretical models assume the charmonium to be a regular QQ¯ state however the possibility of exotics is also viable. In this paper we estimate the low lying masses of the cc¯ mesons using the gaussian wave function within a phenomeno-logical potential model framework. Various L=0 state masses and decay constants are obtained. The results are further compared with other experimental as well as theoretical model predictions

  15. A tracking detector to study O (1 GeV) νμ CC interactions

    International Nuclear Information System (INIS)

    Bernardini, P.; Marsella, G.; Cecchini, S.; Cindolo, F.; D'Antone, I.; Esposti, L. Degli; Lax, I.; Mandrioli, G.; Mauri, N.; Pasqualini, L.; Patrizii, L.; Pozzato, M.; Sirri, G.; Surdo, A.; Tenti, M.

    2017-01-01

    A tracking system composed of planes of triangular shape scintillator bars coupled to Silicon PhotoMultipliers in analog mode read-out has been developed for applications in neutrino experiments. A spatial resolution of O (1 mm) is required for the determination of momentum and charge of muons produced in ν μ CC interactions at few GeV energy scale. The performance of the system has been studied by exposing it to charged particle beams at the CERN-PS. Preliminary results are discussed.

  16. Intelligent CAMAC crate controller with CC-A2 functionality and VICbus interface

    International Nuclear Information System (INIS)

    Erven, W.; Holzer, J.; Kopp, H.; Loevenich, H.W.; Meiling, W.; Zwoll, K.; Bovier, J.; Re, G.; Worm, F.

    1992-01-01

    This paper reports that for nuclear physics experiments at the Julich Cooler Synchrotron COSY a data acquisition system is under development. With this background, and in order to enhance existing CAMAC systems, an intelligent CAMAC crate controller with CC-A2 functionality was developed. The main enhancement is the replacement of the Branch Highway with a new standard of inter-crate connection: the VICbus. The other highlights are: optional use of a Motorola 68030 microprocessor as CAMAC list-processor and optimization of CAMAC blocktransfers, optional Ethernet or Cheapernet connection. This controller is commercially available from CES, Geneva and called VCC 2117

  17. Thermal shock resistances of a bonding material of C/C composite and copper

    International Nuclear Information System (INIS)

    Kurumada, Akira; Oku, Tatsuo; Kawamata, Kiyohiro; Motojima, Osamu; Noda, Nobuaki; McEnaney, B.

    1997-01-01

    The purpose of this study is to contribute to the development and the safety design of plasma facing components for fusion reactor devices. We evaluated the thermal shock resistance and the thermal shock fracture toughness of a bonding material which was jointed a carbon-fiber-reinforced carbon composite (C/C composite) to oxygen-free copper. We also examined the microstructures of the bonding layers using a scanning electron microscope before and after thermal shock tests. The bonding material did not fracture during thermal shock tests. However, thermal cracks and delamination cracks were observed in the bonding layers. (author)

  18. Discontinuing disease-modifying therapy in progressive multiple sclerosis: can we stop what we have started?

    LENUS (Irish Health Repository)

    Lonergan, Roisin

    2012-02-01

    Disease-modifying therapy is ineffective in disabled patients (Expanded Disability Status Scale [EDSS] > 6.5) with secondary progressive multiple sclerosis (MS) without relapses, or in primary progressive MS. Many patients with secondary progressive MS who initially had relapsing MS continue to use disease-modifying therapies. The enormous associated costs are a burden to health services. Regular assessment is recommended to guide discontinuation of disease-modifying therapies when no longer beneficial, but this is unavailable to many patients, particularly in rural areas. The objectives of this study are as follows: 1. To observe use of disease-modifying therapies in patients with progressive multiple sclerosis and EDSS > 6.5. 2. To examine approaches used by a group of international MS experts to stopping-disease modifying therapies in patients with secondary progressive MS without relapses. During an epidemiological study in three regions of Ireland (southeast Dublin city, and Wexford and Donegal Counties), we recorded details of disease-modifying therapies in patients with progressive MS and EDSS > 6.5. An e-questionnaire was sent to 26 neurologists with expert knowledge of MS, asking them to share their approach to stopping disease-modifying therapies in patients with secondary progressive MS. Three hundred and thirty-six patients were studied: 88 from southeast Dublin, 99 from Wexford and 149 from Donegal. Forty-four had EDSS > 6.5: 12 were still using disease-modifying therapies. Of the surveyed neurologists, 15 made efforts to stop disease-modifying therapies in progressive multiple sclerosis, but most did not insist. A significant proportion (12 of 44 patients with progressive MS and EDSS > 6.5) was considered to be receiving therapy without benefit. Eleven of the 12 were from rural counties, reflecting poorer access to neurology services. The costs of disease-modifying therapies in this group (>170,000 euro yearly) could be re-directed towards development

  19. Electronic Stopping Power in LiF from First Principles

    International Nuclear Information System (INIS)

    Pruneda, J. M.; Sanchez-Portal, D.; Arnau, A.; Juaristi, J. I.; Artacho, Emilio

    2007-01-01

    Using time-dependent density-functional theory we calculate from first principles the rate of energy transfer from a moving proton or antiproton to the electrons of an insulating material, LiF. The behavior of the electronic stopping power versus projectile velocity displays an effective threshold velocity of ∼0.2 a.u. for the proton, consistent with recent experimental observations, and also for the antiproton. The calculated proton/antiproton stopping-power ratio is ∼2.4 at velocities slightly above the threshold (v∼0.4 a.u.), as compared to the experimental value of 2.1. The projectile energy loss mechanism is observed to be extremely local

  20. Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage

    DEFF Research Database (Denmark)

    Krishnan, Kailash; Scutt, Polly; Woodhouse, Lisa

    2016-01-01

    BACKGROUND AND PURPOSE: More than 50% of patients with acute intracerebral hemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, whether to continue or stop such treatment during the acute phase of ICH...... remains unclear, a question that was addressed in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. METHODS: ENOS was an international multicenter, prospective, randomized, blinded endpoint trial. Among 629 patients with ICH and systolic blood pressure between 140 and 220 mmHg, 246 patients who were...... taking antihypertensive drugs were assigned to continue (n = 119) or to stop (n = 127) taking drugs temporarily for 7 days. The primary outcome was the modified Rankin Score at 90 days. Secondary outcomes included death, length of stay in hospital, discharge destination, activities of daily living, mood...

  1. Discrete Analysis of Portfolio Selection with Optimal Stopping Time

    Directory of Open Access Journals (Sweden)

    Jianfeng Liang

    2009-01-01

    Full Text Available Most of the investments in practice are carried out without certain horizons. There are many factors to drive investment to a stop. In this paper, we consider a portfolio selection policy with market-related stopping time. Particularly, we assume that the investor exits the market once his wealth reaches a given investment target or falls below a bankruptcy threshold. Our objective is to minimize the expected time when the investment target is obtained, at the same time, we guarantee the probability that bankruptcy happens is no larger than a given level. We formulate the problem as a mix integer linear programming model and make analysis of the model by using a numerical example.

  2. Stopped-pipe wind instruments: Acoustics of the panpipes

    Science.gov (United States)

    Fletcher, N. H.

    2005-01-01

    Stopped-pipe jet-excited musical instruments are known in many cultures, those best-known today being the panpipes or syrinx of Eastern Europe and of the Peruvian Andes. Although the playing style differs, in each case the instrument consists of a set of graduated bamboo pipes excited by blowing across the open tops. Details of the excitation aerodynamics warrant examination, particularly as the higher notes contain amplitudes of the even harmonics approaching those of the odd harmonics expected from a stopped pipe. Analysis shows that the jet offset is controlled by the fluid dynamics of the jet, and is such that appreciable even-harmonic excitation is generated. The theory is largely confirmed by measurements on a player. .

  3. Ball Screw Actuator Including a Stop with an Integral Guide

    Science.gov (United States)

    Wingett, Paul T. (Inventor); Perek, John (Inventor); Geck, Kellan (Inventor)

    2015-01-01

    An actuator includes a housing assembly, a ball nut, a ball screw, and a ball screw stop. The ball nut is rotationally mounted in the housing assembly, is adapted to receive an input torque, and is configured, upon receipt thereof, to rotate and supply a drive force. The ball screw is mounted within the housing assembly and extends through the ball nut. The ball screw has a first end and a second end, and is coupled to receive the drive force from the ball nut. The ball screw is configured, upon receipt of the drive force, to selectively translate between a stow position and a deploy position. The ball screw stop is mounted on the ball screw to translate therewith and is configured to at selectively engage the housing assembly while the ball screw is translating, and engage the ball nut when the ball screw is in the deploy position.

  4. Energy density, stopping and flow in ultrarelativistic heavy ion collisions

    International Nuclear Information System (INIS)

    Sorge, H.; von Keitz, A.; Mattiello, R.; Stoecker, H.; Greiner, W.

    1990-01-01

    The Lorentz invariant molecular dynamics approach (RQMD) is employed to investigate the space-time evolution of heavy ion collisions at energies (E kin = 10AGeV hor-ellipsis 200AGeV). The calculations for various nucleus nucleus reactions show a high degree of stopping power. The importance of secondary rescattering at these beam energies is demonstrated. The computed nucleon rapidity distributions are compared to available experimental data. It is demonstrated that nonlinear, collective effects like full stopping of target and projectile and matter flow could be expected for heavy projectiles only. For nuclear collisions in the Booster era at BNL and for the lead beam at CERN SPS the authors predict a stimulating future: then a nearly equilibrated, long lived (8 fm/c) macroscopic volume of very high energy density (> 1 GeV/fm 3 ) and baryon density (> 5 times ground state density) is produced

  5. Stopping power for heavy ions in gases: a comparative study

    International Nuclear Information System (INIS)

    Diwan, P.K.; Singh, Lakhwant; Singh, Gurinder; Shyam Kumar

    1999-01-01

    The accurate knowledge of stopping power for heavy ions in gases is of paramount importance in nuclear reaction studies for the identification of reaction products involving ΔE-E telescope detectors. In the present work, it has been calculated the stopping power values for different heavy ions, such as Ne, Ar, Cu, Kr and Ag in various gas absorbers like H 2 , He, N 2 , Ne, Ar, Kr and Xe in the energy domain ∼ 2.5-6 MeV/n using the SRIM-98 code recently developed by Ziegler and the formulations of Benton and Henke, Hubert et al, Mukherjee and Nayak and Northcliffe and Schilling. This study has been undertaken in order to establish the validity of various semiempirical formulations for gas targets

  6. Simultaneous wide-range stopping power determination for several ions

    Energy Technology Data Exchange (ETDEWEB)

    Alanko, T. E-mail: tommi.alanko@phys.jyu.fi; Trzaska, W.H.; Lyapin, V.; Raeisaenen, J.; Tiourine, G.; Virtanen, A

    2002-05-01

    A new procedure to extract simultaneously continuous stopping power curves for several ions and several absorbers over a wide energy range and with statistical errors reduced to negligible level is presented. The method combines our novel time-of-flight based method with the capability of our K130 cyclotron and ECR ion-source to produce the so-called ion cocktails. The potential of the method is demonstrated with a 6.0 MeV/u cocktail consisting of {sup 16}O{sup 4+}, {sup 28}Si{sup 7+} and {sup 40}Ar{sup 10+} ions. The stopping power in polycarbonate in the energy range of 0.35-5 MeV/u has been determined with absolute uncertainty of less than 2.3% and with relative below 0.2%. The results are compared with literature data and with SRIM2000 parameterisation including cores and bonds corrections.

  7. Cloning and occurrence of czrC, a gene conferring cadmium and zinc resistance in MRSA CC398 Isolates

    DEFF Research Database (Denmark)

    Cavaco, Lina; Hasman, Henrik; Stegger, Marc

    2010-01-01

    the genetic determinant causing zinc resistance in CC398 and examine its prevalence in isolates of animal and human origin. Based on the sequence of the staphylococcal cassette chromosome mec (SCCmec) element from methicillin-resistant S. aureus (MRSA) CC398 strain SO385, a putative metal resistance gene......-four percent (n = 23) of the animal isolates and 48% (n = 24) of the human MRSA isolates of CC398 were resistant to zinc chloride and positive for czrC. All 48 MSSA strains from both human and pig origins were found to be susceptible to zinc chloride and negative for czrC. Our findings showed that czr......C is encoding zinc and cadmium resistance in CC398 MRSA isolates, and that it is widespread both in humans and animals. Thus, resistance to heavy metals such as zinc and cadmium may play a role in the coselection of methicillin resistance in S. aureus....

  8. Why alite stops hydrating below 80% relative humidity

    International Nuclear Information System (INIS)

    Flatt, Robert J.; Scherer, George W.; Bullard, Jeffrey W.

    2011-01-01

    It has been observed that the hydration of cement paste stops when the relative humidity drops below about 80%. A thermodynamic analysis shows that the capillary pressure exerted at that RH shifts the solubility of tricalcium silicate, so that it is in equilibrium with water. This is a reflection of the chemical shrinkage in this system: according to Le Chatelier's principle, since the volume of the products is less than that of the reactants, a negative (capillary) pressure opposes the reaction.

  9. We Can Stop HIV One Conversation at a Time

    Centers for Disease Control (CDC) Podcasts

    2014-08-28

    As part of the We Can Stop HIV One Conversation at a Time campaign, this 30 second PSA encourages Hispanics/Latinos to talk openly about HIV and AIDS with their families, friends, partners, and communities.  Created: 8/28/2014 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP).   Date Released: 8/28/2014.

  10. City Under Siege: Narrating Mumbai Through NonStop Capture

    OpenAIRE

    Yasmin Ibrahim

    2009-01-01

    When Mumbai became the target of terror in the 26/11 attack in 2008, the events in that city, like other tragic global events in recent years, were narrated through new media platforms. The increasing convergence of technologies and mobile telephony enabled new forms of gaze and the ability to bear witness through these new media technologies. The non-stop capture of events through recording equipment embedded in mobile phones and their connectivity to the World Wide Web constructed Mumbai th...

  11. Clamped seismic metamaterials: ultra-low frequency stop bands

    International Nuclear Information System (INIS)

    Achaoui, Y; Enoch, S; Guenneau, S; Antonakakis, T; Brûlé, S; Craster, R V

    2017-01-01

    The regularity of earthquakes, their destructive power, and the nuisance of ground vibration in urban environments, all motivate designs of defence structures to lessen the impact of seismic and ground vibration waves on buildings. Low frequency waves, in the range 1–10 Hz for earthquakes and up to a few tens of Hz for vibrations generated by human activities, cause a large amount of damage, or inconvenience; depending on the geological conditions they can travel considerable distances and may match the resonant fundamental frequency of buildings. The ultimate aim of any seismic metamaterial, or any other seismic shield, is to protect over this entire range of frequencies; the long wavelengths involved, and low frequency, have meant this has been unachievable to date. Notably this is scalable and the effects also hold for smaller devices in ultrasonics. There are three approaches to obtaining shielding effects: bragg scattering, locally resonant sub-wavelength inclusions and zero-frequency stop-band media. The former two have been explored, but the latter has not and is examined here. Elastic flexural waves, applicable in the mechanical vibrations of thin elastic plates, can be designed to have a broad zero-frequency stop-band using a periodic array of very small clamped circles. Inspired by this experimental and theoretical observation, all be it in a situation far removed from seismic waves, we demonstrate that it is possible to achieve elastic surface (Rayleigh) wave reflectors at very large wavelengths in structured soils modelled as a fully elastic layer periodically clamped to bedrock. We identify zero frequency stop-bands that only exist in the limit of columns of concrete clamped at their base to the bedrock. In a realistic configuration of a sedimentary basin 15 m deep we observe a zero frequency stop-band covering a broad frequency range of 0–30 Hz. (paper)

  12. Stopping Mass Killings in Africa: Genocide, Airpower and Intervention

    Science.gov (United States)

    2008-07-01

    University Press Maxwell Air Force Base, Alabama July 2008 20081027249 Muir S. Fairchild Research Information Center Cataloging Data Stopping mass...commander, who controlled the Habr Gedir subclan, and that of All Mahdi Mohamed, a wealthy Mogadishu hotelier and self- proclaimed interim president of...carry a big stick." Yet both the force com- mander and the AETF commander should think hard before employing that stick. A wide array of actors is

  13. How to Stop the Bear: Strategy of Small States

    Science.gov (United States)

    2010-12-01

    stressing the role of international law, and abstentionism from security alliance” (George J. Stein, 1990, p. 4). At the same time, the Dutch were reluctant...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited HOW TO STOP THE BEAR...estimated to average 1 hour per response, including the time for reviewing instruction, searching existing data sources, gathering and maintaining

  14. One-stop shopping in Africa's minerals supermarket

    International Nuclear Information System (INIS)

    Spira, J.

    1980-01-01

    Johannesburg in South Africa is one of the minerals capitals of the world, providing a one-stop shopping supermarket for the most sought-after strategic minerals. Total annual mineral sales grew from R1563 million in 1970 to R6876 million in 1978. For 1979 the figure exceeded R9700 million. Production, trade and marketing of gold, coal, platinum, uranium, diamonds, iron ore, copper, antimony, mineral sands, asbestos and vanadium are shortly discussed

  15. Analysing passenger arrivals rates and waiting time at bus stops

    OpenAIRE

    Kaparias, I.; Rossetti, C.; Trozzi, V.

    2015-01-01

    The present study investigates the rather under-explored topic of passenger waiting times at public transport facilities. Using data collected from part of London’s bus network by means of physical counts, measurements and observations, and complemented by on-site passenger interviews, the waiting behaviour is analysed for a number of bus stops served by different numbers of lines. The analysis employs a wide range of statistical methods and tools, and concentrates on three aspects: passenger...

  16. High Level Antibody Response to Pandemic Influenza H1N1/09 Virus Is Associated With Interferon-Induced Transmembrane Protein-3 rs12252-CC in Young Adults

    Directory of Open Access Journals (Sweden)

    Ling Qin

    2018-05-01

    Full Text Available Background: The C allele of the interferon-induced transmembrane protein-3 (IFITM3 SNP rs12252, a common allele in South East Asia and China, is strongly associated with severe influenza infection. However, despite the high occurrence of rs12252-CC genotype in Chinese population (~25%, severe influenza infection is rare. The aim of study is to determine whether rs12252-CC individuals have pre-existing antibody responses to previous seasonal influenza infections.Cohort and Method: A total 99 young healthy volunteers (18–20 years were recruited and received an influenza seasonal Vaccination [A/Switzerland/9715293/2013(H3N2, A/California/7/2009 (pdm09H1N1 and B/Jeep/3073/2013-like virus (Flu-B]. Plasma and gDNA was isolated from each volunteer before, and 14, 28, 180, 360, and 540 days after vaccination. Additionally, 68 elderlies (>65 years were also recruited as a control group to compare the levels of antibodies at baseline between the young adults and the elderly. For each sample IFITM3 rs12252 genotype was determined and antibody levels in response to pdmH1N1, H3N2 and Influenza B infection were measured for each time point.Results: We found a significantly higher level of pre-existing antibodies to pandemic influenza H1N1/09 virus (pdm09H1N1 but not to H3N2 or FluB in CC donors in comparison with CT/TT donors prior to vaccination. No impact of IFITM3 genotype in boosting influenza specific antibodies in young adults within 1 year after receiving seasonal influenza vaccination was observed. In addition, there was no difference in pdm09H1N1 specific antibody levels observed in the elderly cohort between volunteers carrying different IFITM3 genotypes. Higher levels of antibodies to pdmH1N1 were observed in elderly CC carriers when compared to the young CC carriers, but this trend was not replicated in TT carriers.Conclusion:IFITM3-rs12252 CC carriers exhibit a high level of pre-existing immunity to pdm09H1N1 compared to TT carriers in the

  17. Scattering and stopping of swift diatomic molecules under Coulomb explosion

    International Nuclear Information System (INIS)

    Sigmund, P.

    1992-01-01

    The scattering and stopping of the fragments of a fast diatomic molecule under Coulomb explosion has been analysed theoretically. The central assumption in the scheme is the dominance of Coulomb explosion, while electronic stopping (including wake forces) and elastic scattering are treated as perturbations. Charge exchange has been neglected. Coulomb images of penetration phenomena are heavily distorted. For small penetrated layer thicknesses, images appear contracted in the direction of the molecular axis, and expanded perpendicular to it. This distortion is described quantitatively by a linear transformation. General expressions have been derived for the effect of continuous and stochastic forces on the distribution of fragment velocities from Coulomb explosion (the ''ring pattern''). Moreover, relations have been found that allow to scale velocity distributions valid in the absence of Coulomb explosion into distributions allowing for Coulomb explosion. Applications concern the shift in ring pattern due to electronic stopping, the lateral broadening due to multiple scattering, and the effect of zero-point motion on the Coulomb image of a molecule. (orig.)

  18. Scattering and stopping of swift diatomic molecules under Coulomb explosion

    International Nuclear Information System (INIS)

    Sigmund, P.

    1991-01-01

    The scattering and stopping of the fragments of a fast diatomic molecule under Coulomb explosion has been analyzed theoretically. The central assumption in the scheme is the dominance of Coulomb explosion, while electronic stopping (including wake forces) and elastic scattering are treated as perturbations. Charge exchange has been neglected. Coulomb images of penetration phenomena are heavily distorted. For small penetrated layer thicknesses, images appear contracted in the direction of the molecular axis, and expanded perpendicular to it. This distortion is described quantitatively by a linear transformation. General expressions have been derived for the effect of continuous and stochastic forces on the distribution of fragment velocities from Coulomb explosion (the ''ring pattern''). Moreover, relations have been found that allow to scale velocity distributions valid in the absence of Coulomb explosion into distributions allowing for Coulomb explosion. Applications concern the shift in ring pattern due to electronic stopping, the lateral broadening due to multiple scattering and the effect of zero-point motion on the Coulomb image of a molecule. 14 refs., 5 figs

  19. Correlated stopping, proton clusters and higher order proton cumulants

    Energy Technology Data Exchange (ETDEWEB)

    Bzdak, Adam [AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Krakow (Poland); Koch, Volker [Lawrence Berkeley National Laboratory, Nuclear Science Division, Berkeley, CA (United States); Skokov, Vladimir [RIKEN/BNL, Brookhaven National Laboratory, Upton, NY (United States)

    2017-05-15

    We investigate possible effects of correlations between stopped nucleons on higher order proton cumulants at low energy heavy-ion collisions. We find that fluctuations of the number of wounded nucleons N{sub part} lead to rather nontrivial dependence of the correlations on the centrality; however, this effect is too small to explain the large and positive four-proton correlations found in the preliminary data collected by the STAR collaboration at √(s) = 7.7 GeV. We further demonstrate that, by taking into account additional proton clustering, we are able to qualitatively reproduce the preliminary experimental data. We speculate that this clustering may originate either from collective/multi-collision stopping which is expected to be effective at lower energies or from a possible first-order phase transition, or from (attractive) final state interactions. To test these ideas we propose to measure a mixed multi-particle correlation between stopped protons and a produced particle (e.g. pion, antiproton). (orig.)

  20. When can immunotherapy for insect sting allergy be stopped?

    Science.gov (United States)

    Müller, Ulrich R; Ring, Johannes

    2015-01-01

    Stings by Hymenoptera (honey bees, vespids, ants) can cause systemic allergic reactions (SARs). Venom immunotherapy (VIT) is highly effective and reduces an allergic patient's risk of a recurrent SAR to less than 5-20%. The risk of a recurrent SAR to a re-sting decreases the longer VIT is continued. The recommended duration of VIT is at least 3 to 5 years. Risk factors for recurrent SARs to a sting after stopping VIT have been identified and discussed: Recommendations concerning stopping VIT: For patients without any of the identified risk factors, VIT should be continued for 5 rather than 3 years. In patients with definite risk factors, a longer duration of VIT has to be discussed before stopping it. In mast cell disorders, VIT for life is recommended. Because of the residual risk of SARs after VIT, all patients are advised to carry an epinephrine autoinjector indefinitely and to continue to take measures to avoid Hymenoptera stings. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.