WorldWideScience

Sample records for grounding line position

  1. Hydrostatic grounding line parameterization in ice sheet models

    Directory of Open Access Journals (Sweden)

    H. Seroussi

    2014-06-01

    Full Text Available Modeling of grounding line migration is essential to simulate accurately the behavior of marine ice sheets and investigate their stability. Here, we assess the sensitivity of numerical models to the parameterization of the grounding line position. We run the MISMIP3D benchmark experiments using a two-dimensional shelfy-stream approximation (SSA model with different mesh resolutions and different sub-element parameterizations of grounding line position. Results show that different grounding line parameterizations lead to different steady state grounding line positions as well as different retreat/advance rates. Our simulations explain why some vertically depth-averaged model simulations exhibited behaviors similar to full-Stokes models in the MISMIP3D benchmark, while the vast majority of simulations based on SSA showed results deviating significantly from full-Stokes results. The results reveal that differences between simulations performed with and without sub-element parameterization are as large as those performed with different approximations of the stress balance equations and that the reversibility test can be passed at much lower resolutions than the steady-state grounding line position. We conclude that fixed grid models that do not employ such a parameterization should be avoided, as they do not provide accurate estimates of grounding line dynamics, even at high spatial resolution. For models that include sub-element grounding line parameterization, a mesh resolution lower than 2 km should be employed.

  2. Structure and form of grounding lines of modern ice sheets

    Science.gov (United States)

    Tinto, K. J.; Bell, R. E.; Cochran, J. R.; Boghosian, A.; Porter, D. F.

    2015-12-01

    The form of the bed at the grounding line of a glacier and the character of the underlying rock can be critical to the stability of the glacier. Aerogravity measurements offer a unique insight in to the character of the grounding line environment. By combining depth measurements from further onshore radar and geological information from magnetic surveys, gravity-based models can reveal both the depth and slope of the bed at the grounding line. Where bed elevation is known at the grounding line, gravity models can show the density structure of the underlying rock. Operation IceBridge has flown coincident radar, lidar, photography, gravity and magnetic airborne surveys along fjords and over ice shelves in both Greenland and Antarctica. Aerogravity measurements have been used extensively to model the bathymetry of the sea floor in front of the grounding line, and to identify the depth of the grounding line in areas where radar measurements have proven challenging. These models have also been used to reveal the range of conditions at present day grounding lines, as well as those experienced in the past and predicted for future grounding line positions. In some regions, we have identified low-density sediment accumulations, at both present day grounding lines and within fjords, that we interpret to be terminal moraines deposited by the glacier itself during hiatuses in retreat. In other regions, we find that the present day grounding line is stalled on a ridge of high-density rock. Ridges such as these remain in the same position through many cycles of advance and retreat of the glacier. Our synthesis of gravity data from a wide range of glacial environments can be used to identify likely drivers of change at the grounding line, whether this is the depth, the slope, or the geological character of the glacier bed.

  3. West Antarctic Ice Sheet Grounding-Line Positions in the Whales Deep Paleo-Ice-Stream Trough of Eastern Ross Sea Inferred From New Multibeam bBathymetry and Seismic Stratigraphy

    Science.gov (United States)

    Bart, P. J.; DeCesare, M.; McGlannan, A. J.; Krogmeier, B.; Danielson, M.

    2016-12-01

    Regional dip-oriented seismic lines and a large-area (2500 km2) multibeam bathymetric survey were acquired during expedition NBP1502B in the Whales Deep paleo-ice-stream trough of eastern Ross Sea. This outer-shelf trough is the downstream continuation of the Bindschadler Ice Stream. The new data provide a more detailed 3D view of the time-transgressive erosional and depositional seafloor features formed during West Antarctic Ice Sheet (WAIS) advance and retreat than was possible to reconstruct with previous reconnaissance-level multibeam and seismic data. The multibeam survey also provides the opportunity to conduct a more detailed analysis of core sedimentology and stratigraphy (McGlannan et al.) that can ultimately be used to investigate grounding-event chronology (DeCesare et al.). The geophysical data show that the WAIS occupied at least four grounding-line positions as it retreated 40 km from the shelf edge to the middle shelf. After the fourth grounding event at the middle shelf, grounded ice retreated abruptly by >200 km to an area/zone south of the modern calving front - where it may have pinned at Roosevelt Island.

  4. AMS Ground Truth Measurements: Calibration and Test Lines

    Energy Technology Data Exchange (ETDEWEB)

    Wasiolek, P. [National Security Technologies, LLC. (NSTec), Mercury, NV (United States)

    2013-11-01

    Airborne gamma spectrometry is one of the primary techniques used to define the extent of ground contamination after a radiological incident. Its usefulness was demonstrated extensively during the response to the Fukushima nuclear power plant (NPP) accident in March-May 2011. To map ground contamination a set of scintillation detectors is mounted on an airborne platform (airplane or helicopter) and flown over contaminated areas. The acquisition system collects spectral information together with the aircraft position and altitude every second. To provide useful information to decision makers, the count rate data expressed in counts per second (cps) needs to be converted to the terrestrial component of the exposure rate 1 m above ground, or surface activity of isotopes of concern. This is done using conversion coefficients derived from calibration flights. During a large scale radiological event, multiple flights may be necessary and may require use of assets from different agencies. However, as the production of a single, consistent map product depicting the ground contamination is the primary goal, it is critical to establish very early into the event a common calibration line. Such a line should be flown periodically in order to normalize data collected from different aerial acquisition systems and potentially flown at different flight altitudes and speeds. In order to verify and validate individual aerial systems, the calibration line needs to be characterized in terms of ground truth measurements. This is especially important if the contamination is due to short-lived radionuclides. The process of establishing such a line, as well as necessary ground truth measurements, is described in this document.

  5. Ground Loop Impedance of Long EHV Cable Lines

    DEFF Research Database (Denmark)

    Ohno, Teruo; Bak, Claus Leth; Sørensen, Thomas K.

    2012-01-01

    The distance protection scheme without communication is often applied to the backup protection of EHV cable lines. For a reliable operation of a ground distance relay, the ground loop impedance of EHV cable lines needs to have a linear relationship to the distance from the relay location to the f...

  6. Ground Fault Line Selection with Improved Residual Flow Incremental Method

    Directory of Open Access Journals (Sweden)

    Wenhong Li

    2013-08-01

    Full Text Available According to the shortcoming of single-phase ground fault line selection method in the resonant grounded system such as the uncertainty of its device by fast compensation with the automatic compensation equipment, an arc suppression and residual flow incremental method is proposed to effectively choose the earth fault line. Firstly, when the single-phase ground fault occurs, the arc suppression coil parameters are adjusted to realize compensation and arc suppression. Then the arc suppression coil inductance values are modulated to make the zero-sequence current of fault line changed, at the same time, the zero-sequence current value is detected and its change will be captured to select the fault line. The simulation experiments prove that the arc grounding over voltage damage can be effectively reduced by arc suppression coil full compensation and fault line can be effectively selected by arc suppression and residual flow increment method.

  7. Grounds of two positions photovoltaic panels

    OpenAIRE

    Castán Fortuño, Fernando

    2008-01-01

    The objective of this Master Thesis is to find the optimum positioning for a two positions photovoltaic panel. Hence, it will be implemented a model in order to optimize the energy of the sun that the photovoltaic panel is receiving by its positioning. Likewise this project will include the comparison with other photovoltaic panel systems as the single position photovoltaics panels. Ultimately, it is also going to be designed a system array for the optimized model of two positions photovoltai...

  8. Stable Delay of Microstrip Line with Side Grounded Conductors

    Directory of Open Access Journals (Sweden)

    T. R. Gazizov

    2017-01-01

    Full Text Available Characteristics of transmission lines are addressed. Wave impedance and per-unit-length delay of the microstrip structure with grounded side conductors on three layers are calculated under different parameters of the structure. A line which provides the desired value of wave impedance and constant per-unit-length delay, at the expense of correction of the gaps on different layers, is proposed.

  9. Comb-Line Filter with Coupling Capacitor in Ground Plane

    Directory of Open Access Journals (Sweden)

    Toshiaki Kitamura

    2011-01-01

    Full Text Available A comb-line filter with a coupling capacitor in the ground plane is proposed. The filter consists of two quarter-wavelength microstrip resonators. A coupling capacitor is inserted into the ground plane in order to build strong coupling locally along the resonators. The filtering characteristics are investigated through numerical simulations as well as experiments. Filtering characteristics that have attenuation poles at both sides of the passband are obtained. The input susceptances of even and odd modes and coupling coefficients are discussed. The filters using stepped impedance resonators (SIRs are also discussed, and the effects of the coupling capacitor for an SIR structure are shown.

  10. Grounding line variability and subglacial lake drainage on Pine Island Glacier, Antarctica

    Science.gov (United States)

    Joughin, Ian; Shean, David E.; Smith, Ben E.; Dutrieux, P.

    2016-09-01

    We produced a 6 year time series of differential tidal displacement for Pine Island Ice Shelf, Antarctica, using speckle-tracking methods applied to fine-resolution TerraSAR-X data. These results reveal that the main grounding line has maintained a relatively steady position over the last 6 years, following the speedup that terminated in ~2009. In the middle of the shelf, there are grounded spots that migrate downstream over the 6 year record. Examination of high-resolution digital elevation models reveals that these grounded spots form where deep keels (thickness anomalies) advect over an approximately flow-parallel bathymetric high, maintaining intermittent contact with the bed. These data sets also reveal several subsidence and uplift events associated with subglacial lake drainages in the fast-flowing region above the grounding line. Although these drainages approximately double the rate of subglacial water flow over periods of a few weeks, they have no discernible effect on horizontal flow speed.

  11. Geometric Calibration of ZIYUAN-3 Three-Line Cameras Combining Ground Control Points and Lines

    Science.gov (United States)

    Cao, Jinshan; Yuan, Xiuxiao; Gong, Jianya

    2016-06-01

    Due to the large biases between the laboratory-calibrated values of the orientation parameters and their in-orbit true values, the initial direct georeferencing accuracy of the Ziyuan-3 (ZY-3) three-line camera (TLC) images can only reach the kilometre level. In this paper, a point-based geometric calibration model of the ZY-3 TLCs is firstly established by using the collinearity constraint, and then a line-based geometric calibration model is established by using the coplanarity constraint. With the help of both the point-based and the line-based models, a feasible in-orbit geometric calibration approach for the ZY-3 TLCs combining ground control points (GCPs) and ground control lines (GCLs) is presented. Experimental results show that like GCPs, GCLs can also provide effective ground control information for the geometric calibration of the ZY-3 TLCs. The calibration accuracy of the look angles of charge-coupled device (CCD) detectors achieved by using the presented approach reached up to about 1.0''. After the geometric calibration, the direct georeferencing accuracy of the ZY-3 TLC images without ground controls was significantly improved from the kilometre level to better than 11 m in planimetry and 9 m in height. A more satisfactory georeferencing accuracy of better than 3.5 m in planimetry and 3.0 m in height was achieved after the block adjustment with four GCPs.

  12. Decreasing costs of ground data processing system development using a software product line

    Science.gov (United States)

    Chaffin, Brian

    2005-01-01

    In this paper, I describe software product lines and why a Ground Data Processing System should use one. I also describe how to develop a software product line, using examples from an imaginary Ground Data Processing System.

  13. Features of positive ground flashes observed in Kathmandu Nepal

    Science.gov (United States)

    Adhikari, Pitri Bhakta; Sharma, Shriram; Baral, Kedarnath

    2016-07-01

    Lightning vertical electric fields pertinent to the subtropical thunderstorms occurring over the rugged terrain have been measured and recorded at a hilly station Kathmandu, Nepal. In the present work, waveforms of the positive ground flashes have been selected from all the records and were analyzed. To the best of our knowledge, this is the first time that fine structure of electric field signature pertinent to the positive return stroke; have been analyzed and presented from Nepal. One hundred and thirty three (133) of the total of four hundred twenty-five (425) flashes were selected from seven thunderstorm days and analyzed. Of the data recorded for seven days, 133 flashes (31.3%) were positive flashes and 276 flashes (64.9%) were cloud flashes. Majority of the positive ground flashes were found to be single stroke ones, whereas, the average number of strokes per flash is found to be 1.1 with a maximum value of 4. Majority of the positive ground flashes were found either lacking the initial breakdown process and the leader stage or these processes could not be detected. The return strokes are found to be succeeded by large in cloud activity in the continuing current portion of the flash. The average zero-crossing time of the positive return strokes was found to be 60.45 μs with a range of 447.81 μs and the average rise time was found to be 9.44 μs with a range of 42.56 μs.

  14. RF radiation observations of positive cloud-to-ground flashes

    Science.gov (United States)

    Shao, X. M.; Rhodes, C. T.; Holden, D. N.

    1999-04-01

    During the summers of 1995 and 1996 we conducted broadband HF-UHF and narrowband VHF radio frequency (RF) observations of positive cloud-to-ground (+CG) flashes at Langmuir and Los Alamos laboratories, New Mexico. These observations indicate that positive leaders to ground produce no or very weak radiation from HF to UHF. The broadband system was able to record 2 ms data each time it was triggered. For a +CG the system was usually triggered by the return stroke, and a 1 ms pretrigger period was coincident with the positive leader process. It was commonly observed that no or little radiation was associated with the leader process in the 1 ms pretrigger period. The narrowband VHF system employed a logarithmic power amplifier and recorded one 1 s data each time it was triggered. The narrowband observations show that strong and often continuous radiation occurs at the beginning of the +CGs, but the radiation usually becomes intermittent and impulsive during the last few tens of milliseconds preceding the return strokes. The observations for most of the +CGs also show complete lack of radiation a few ms before the beginning of the return strokes, suggesting that the ongoing downward positive leaders were quiet at VHF, at least during the final few ms. The results of this study for natural positive leaders are in agreement with the results obtained from laboratory gap discharges and rocket-triggered lightning.

  15. Weak positive cloud-to-ground flashes in Northeastern Colorado

    Science.gov (United States)

    Lopez, Raul E.; Maier, Michael W.; Garcia-Miguel, Juan A.; Holle, Ronald L.

    1991-01-01

    The frequency distributions of the peak magnetic field associated with the first detected return stroke of positive and negative cloud-to-ground (CG) flashes were studied using lightning data from northeastern Colorado. These data were obtained during 1985 with a medium-to-high gain network of three direction finders (DF's). The median signal strength of positive flashes was almost two times that of the negatives for flashes within 300 km of the DF's, which have an inherent detection-threshold bias that tends to discriminate against weak signals. This bias increases with range, and affects the detection of positive and negative flashes in different ways, because of the differing character of their distributions. Positive flashes appear to have a large percentage of signals clustered around very weak values that are lost to the medium-to-high gain Colorado Detection System very quickly with increasing range. The resulting median for positive signals could thus appear to be much larger than the median for negative signals, which are more clustered around intermediate values. When only flashes very close to the DF's are considered, however, the two distributions have almost identical medians. The large percentage of weak positive signals detected close to the DF's has not been explored previously. They have been suggested to come from intracloud discharges and thus are improperly classified as CG flashes. Evidence in hand, points to their being real positive, albeit weak CG flashes. Whether or not they are real positive ground flashes, it is important to be aware of their presence in data from magnetic DF networks.

  16. DORIS Starec ground antenna characterization and impact on positioning

    Science.gov (United States)

    Tourain, C.; Moreaux, G.; Auriol, A.; Saunier, J.

    2016-12-01

    In a geodetic radio frequency observing system the phase center offsets and phase center variations of ground antennae are a fundamental component of mathematical models of the system observables. In this paper we describe work aimed at improving the DORIS Starec ground antenna phase center definition model. Seven antennas were analyzed in the Compact Antenna Test Range (CATR), a dedicated CNES facility. With respect to the manufacturer specified phase center offset, the measured antennae varied between -6 mm and +4 mm due to manufacturing variations. To solve this problem, discussions were held with the manufacturer, leading to an improvement of the manufacturing process. This work results in a reduction in the scatter to ±1 mm. The phase center position has been kept unchanged and associated phase law has been updated and provided to users of the International DORIS Service (IDS). This phase law is applicable to all Starec antennas (before and after manufacturing process consolidation) and is azimuth independent. An error budget taking into account these updated characteristics has been established for the antenna alone: ±2 mm on the horizontal plane and ±3 mm on the up component, maximum error values for antennas named type C (Saunier et al., 2016) produced with consolidated manufacturing process. Finally the impact of this updated characterization on positioning results has been analyzed and shows a scale offset only of the order of +12 mm for the Terrestrial Reference Frame.

  17. Evaluation of Fibre Lifetime in Optical Ground Wire Transmission Lines

    Science.gov (United States)

    Grunvalds, R.; Ciekurs, A.; Porins, J.; Supe, A.

    2017-06-01

    In the research, measurements of polarisation mode dispersion of two OPGWs (optical ground wire transmission lines), in total four fibres, have been carried out, and the expected lifetime of the infrastructure has been assessed on the basis of these measurements. The cables under consideration were installed in 1995 and 2011, respectively. Measurements have shown that polarisation mode dispersion values for cable installed in 1995 are four times higher than that for cable installed in 2011, which could mainly be explained by technological differences in fibre production and lower fibre polarisation mode dispersion requirements in 1995 due to lack of high-speed (over 10 Gbit/s) optical transmission systems. The calculation methodology of non-refusal work and refusal probabilities, using the measured polarisation mode dispersion parameters, is proposed in the paper. Based on reliability calculations, the expected lifetime is then predicted, showing that all measured fibres most likely will be operational within minimum theoretical service life of 25 years accepted by the industry.

  18. A Comparative Parametric Analysis of the Ground Fault Current Distribution on Overhead Transmission Lines

    OpenAIRE

    VINTAN, M.

    2016-01-01

    The ground fault current distribution in an effectively grounded power network is affected by various factors, such as: tower footing impedances, spans lengths, configuration and parameters of overhead ground wires and power conductors, soil resistivity etc. In this paper, we comparatively analyze, using different models, the ground fault current distribution in a single circuit transmission line with one ground wire. A parametric comparative analysis was done in order to stud...

  19. General Fault Admittance Method Line-To-Line-To-Ground Faults In Reference And Odd Phases J.D. Sakala, J.S.J. Daka

    Directory of Open Access Journals (Sweden)

    J.D. Sakala,

    2014-02-01

    Full Text Available Line-to-line-to-ground faults are usually analysed using connection of symmetrical component networks at the fault point. As a first step, a reference phase is chosen which results in the simplest connection of the symmetrical component sequence networks for the fault. The simplest connection of symmetrical component sequence networks is a parallel one of the positive, negative and zero sequence networks when phase a of an abc phase sequence is the reference phase and the fault is taken to be between the b and c phases and ground. Putting the fault on an odd phase, say between the a and c phases and ground results in a parallel connection of the positive, negative and zero sequence networks that involve phase shifts, and the solution is more demanding. In practice, the results for the line-to-line-to-ground fault for the reference phase a may be translated to a fault on odd phases by appropriate substitution of phases. In this approach, the solution proceeds by assuming that the fault is in phases b and c and ground and that the symmetrical sequence networks are connected in parallel. The solution of the fault on b and c phases and ground is then translated to apply to the fault on odd phases, say either between phases c and a and ground or between phases a and b and ground. Alternatively, the parallel connection of the sequence networks at the fault point for the odd phases fault is solved for the symmetrical component currents and voltages.

  20. Positioning Optimization Technique in Non-Line-of-Sight Environment

    Directory of Open Access Journals (Sweden)

    Huamei Xin

    2011-02-01

    Full Text Available A positioning optimization technique for non-line-of-sight environment is presented based on weighted orthogonal polynomial fitting technique and singular value decomposition. First, non-line-of-sight errors in TOA measurements are mitigated using weighted orthogonal polynomial fitting technique and the true range between the measuring terminal and the mobile station is approximated. Then the standard deviation of error in line-of-sight environment is exploited to give an optimal location estimation of the mobile station. Short-range measurements from movable measuring terminals are also included to overcome the performance limitation imposed by the measuring terminal bottleneck and translate the spatial reused benefits into positioning accuracy enhancement. Simulation and comparison results show that the proposed algorithm can get better performance measure and achieve high level of positioning accuracy in severe NLOS environment.

  1. Decoupled Magnetoquasistatic Non-Line-of-Sight Position and Orientation Sensing for Arbitrary Distances

    Science.gov (United States)

    Arumugam, Darmindra D. (Inventor)

    2017-01-01

    Methods and systems for non-line-of-sight positioning are disclosed for arbitrarily short to long ranges, where positioning is achieved using a single anchor not requiring tri-/multi-lateration or tri-/multi-angulation. Magnetoquasistatic fields can be used to determine position and orientation of a device in two or three dimensions. Two or three axis coils can be used in receivers and transmitters. The magnetoquasistatic equations are solved in different scenarios, taking into consideration the image signals originating from the interaction between the fields and ground/earth.

  2. Modelling positional uncertainty of line features by accounting for stochastic deviations from straight line segments

    NARCIS (Netherlands)

    Bruin, de S.

    2008-01-01

    The assessment of positional uncertainty in line and area features is often based on uncertainty in the coordinates of their elementary vertices which are assumed to be connected by straight lines. Such an approach disregards uncertainty caused by sampling and approximation of a curvilinear feature

  3. Estimation of Initial Position Using Line Segment Matching in Maps

    Directory of Open Access Journals (Sweden)

    Chongyang Wei

    2016-06-01

    Full Text Available While navigating in a typical traffic scene, with a drastic drift or sudden jump in its Global Positioning System (GPS position, the localization based on such an initial position is unable to extract precise overlapping data from the prior map in order to match the current data, thus rendering the localization as unfeasible. In this paper, we first propose a new method to estimate an initial position by matching the infrared reflectivity maps. The maps consist of a highly precise prior map, built with the offline simultaneous localization and mapping (SLAM technique, and a smooth current map, built with the integral over velocities. Considering the attributes of the maps, we first propose to exploit the stable, rich line segments to match the lidar maps. To evaluate the consistency of the candidate line pairs in both maps, we propose to adopt the local appearance, pairwise geometric attribute and structural likelihood to construct an affinity graph, as well as employ a spectral algorithm to solve the graph efficiently. The initial position is obtained according to the relationship between the vehicle’s current position and matched lines. Experiments on the campus with a GPS error of dozens of metres show that our algorithm can provide an accurate initial value with average longitudinal and lateral errors being 1.68m and 1.04m, respectively.

  4. Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Ground-Based Global Positioning System (GPS) Meteorology Integrated Precipitable Water Vapor (IPW) data set measures atmospheric water vapor using ground-based...

  5. A Comparative Parametric Analysis of the Ground Fault Current Distribution on Overhead Transmission Lines

    Directory of Open Access Journals (Sweden)

    VINTAN, M.

    2016-02-01

    Full Text Available The ground fault current distribution in an effectively grounded power network is affected by various factors, such as: tower footing impedances, spans lengths, configuration and parameters of overhead ground wires and power conductors, soil resistivity etc. In this paper, we comparatively analyze, using different models, the ground fault current distribution in a single circuit transmission line with one ground wire. A parametric comparative analysis was done in order to study the effects of the non-uniformity of the towers footing impedances, number of power lines spans, soil resistivity, grounding systems resistances of the terminal substations etc., on the ground fault current distribution. There are presented some useful qualitative and quantitative results obtained through a complex dedicated developed MATLAB 7.0 program.

  6. Coupling Between Microstrip Lines and Finite Ground Coplanar Lines Embedded in Polyimide Layers for 3D-MMICs on Silicon

    Science.gov (United States)

    Ponchak, G. E.; Bushyager, N.; Papapolymerou, J.; Tentzeris, E. M.; Laskar, J.

    2002-01-01

    Three-dimensional circuits built upon multiple layers of polyimide are required for constructing Si/SiGe monolithic microwave/mm-wave integrated circuits on CMOS (low resistivity) Si wafers. It is expected that these circuits will replace the ones fabricated on GaAs and reduce the overall system cost. However, the closely spaced transmission lines that are required for a high-density circuit environment are susceptible to high levels of cross-coupling, which degrades the overall circuit performance. In this paper, theoretical and experimental results on coupling and ways to reduce it are presented for two types of transmission lines: a) the microstrip line and b) the Finite Ground Coplanar (FGC) line. For microstrip lines it is shown that a fence of metalized via-holes can significantly reduce coupling, especially in the case when both lines are on the same polyimide layer or when the shielding structure extends through several polyimide layers. For closely spaced microstrip lines, coupling is lower for a metal filled trench shield than a via-hole fence. Coupling amongst microstrip lines is dependent on the ratio of line separation to polyimide thickness and is primarily due to magnetic fields. For FGC lines it is shown that they have in general low coupling that can be reduced significantly when there is even a small gap between the ground planes of each line. FGC lines have approximately 8 dB lower coupling than coupled coplanar waveguides (CPW). In addition, forward and backward characteristics of the FGC lines do not resemble those of other transmission lines such as microstrip. Therefore, the coupling mechanism of the FGC lines is different compared to thin film microstrip lines.

  7. Sonography-guided positioning of intravenous long lines in neonates

    Energy Technology Data Exchange (ETDEWEB)

    Brissaud, Olivier, E-mail: olivier.brissaud@chu-bordeaux.f [Neonatal and Pediatric Intensive Care Unit, Children' s Hospital, Bordeaux (France); Harper, Luke, E-mail: luke.harper@chu-bordeaux.f [Paediatric Surgery Unit, Children' s Hospital, Bordeaux (France); Lamireau, Delphine, E-mail: delphine.lamireau@chu-bordeaux.f [Neonatal and Pediatric Intensive Care Unit, Children' s Hospital, Bordeaux (France); Jouvencel, Philippe, E-mail: pjouvencel@chicb.co [Neonatal and Pediatric Intensive Care Unit, Children' s Hospital, Bordeaux (France); Fayon, Michael, E-mail: michael.fayon@chu-bordeaux.f [Paediatric Pneumology Unit Children' s Hospital, Bordeaux (France)

    2010-06-15

    Objective: In neonates, proper positioning of the tip of intravenous long lines (LL) is essential in order to prevent potential life-threatening complications. The gold standard for the evaluation of LL position in neonates is the chest X-ray with or without contrast. We performed a prospective study to assess the use of transthoracic ultrasonography (US) for the positioning of LL in neonates and to compare it to plain radiography. Materials and method: Thirty-six consecutive neonates requiring percutaneous LL over a period of 3 months were included in the study. Immediately after LL insertion, the position of its tip was verified using transthoracic US, followed by plain radiography. The two techniques were compared in terms of adequate placement and length of time between insertion and radiographic evaluation of the correct position. Results: The correlation between positioning by US and plain radiography was very good (r = 0.97, r{sup 2} = 0.94, p < 0.0001). The time needed to verify LL placement by US was shorter by a mean 15 min compared to plain radiography. Conclusion: US can accurately guide LL tip positioning. We believe that because of the potential gain of time it offers and its lack of ionising radiation, it to be considered as an interesting tool for the positioning of LL in neonates. Yet more accurate results could be obtained with a better-trained staff.

  8. Structural responses of secondary lining of high-speed railway tunnel excavated in loess ground

    OpenAIRE

    Zhang, Dingli; Fang, Qian; Li, Pengfei; Wong, Louis

    2013-01-01

    To systematically study the mechanical properties and structural responses of the secondary lining for high-speed railway tunnels excavated in loess ground, on-site monitoring was performed to measure the contact pressure between the primary lining and secondary lining. It is found that the contact pressure reaches its first peak value when the tunnel formwork carriage is removed. The load acting on secondary lining is in the form of deformation pressure, which is different from the loose pre...

  9. Detection of Rockfall on a Tunnel Concrete Lining with Ground-Penetrating Radar (GPR)

    Science.gov (United States)

    Lalagüe, Anne; Lebens, Matthew A.; Hoff, Inge; Grøv, Eivind

    2016-07-01

    Experiments were conducted using Ground-Penetrating Radar (GPR). The performance of six GPR systems was assessed in terms of: (1) remotely mapping cavities behind concrete linings, (2) detecting rockfall from the tunnel roof onto an inner lining comprising, for example, precast concrete segments. Studies conducted in Norway and the United States demonstrate that the GPR technique is a simple and reliable method that can assist stability inspection in existing Norwegian tunnels. The ground-coupled GPR systems represent a step forward in the remote detection of rockfall on tunnel concrete linings, and are particularly suited to self-standing inner linings. The analysis of the data is relatively straightforward and reasonably accurate.

  10. The influence of grounded electrode positions on the evolution and characteristics of an atmospheric pressure argon plasma jet

    Science.gov (United States)

    Zhang, Bo; Zhu, Ying; Liu, Feng; Fang, Zhi

    2017-06-01

    An atmospheric pressure plasma jet (APPJ) in Ar with various grounded electrode arrangements is employed to investigate the effects of electrode arrangement on the characteristics of the APPJ. Electrical and optical methods are used to characterize the plasma properties. The discharge modes of the APPJ with respect to applied voltage are studied for grounded electrode positions of 10 mm, 40 mm and 80 mm, respectively, and the main discharge and plasma parameters are investigated. It is shown that an increase in the distance between the grounded electrode and high-voltage electrode results in a change in the discharge modes and discharge parameters. The discharges transit from having two discharge modes, dielectric barrier discharge (DBD) and jet, to having three, corona, DBD and jet, with increase in the distance from the grounded to the high-voltage electrodes. The maximum length of the APPJ reaches 3.8 cm at an applied voltage of 8 kV. The discharge power and transferred charges and spectral line intensities for species in the APPJ are influenced by the positions of the grounded electrode, while there is no obvious difference in the values of the electron excited temperature (EET) for the three grounded electrode positions.

  11. The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets

    OpenAIRE

    Cooper, Scott T.; Richters, Karl E.; Melin, Travis E.; Liu, Zhi-Jian; Hordyk, Peter J.; Benrud, Ryan R.; Geiser, Lauren R.; Cash, Steve E.; Simon Shelley, C.; Howard, David R.; Ereth, Mark H.; Sola-Visner, Martha C.

    2012-01-01

    Hibernating mammals have developed many physiological adaptations to extreme environments. During hibernation, 13-lined ground squirrels (Ictidomys tridecemlineatus) must suppress hemostasis to survive prolonged body temperatures of 4–8°C and 3–5 heartbeats per minute without forming lethal clots. Upon arousal in the spring, these ground squirrels must be able to quickly restore normal clotting activity to avoid bleeding. Here we show that ground squirrel platelets stored in vivo at 4–8°C wer...

  12. Ground-Wave Propagation Effects on Transmission Lines through Error Images

    Directory of Open Access Journals (Sweden)

    Uribe-Campos Felipe Alejandro

    2014-07-01

    Full Text Available Electromagnetic transient calculation of overhead transmission lines is strongly influenced by the natural resistivity of the ground. This varies from 1-10K (Ω·m depending on several media factors and on the physical composition of the ground. The accuracy on the calculation of a system transient response depends in part in the ground return model, which should consider the line geometry, the electrical resistivity and the frequency dependence of the power source. Up to date, there are only a few reports on the specialized literature about analyzing the effects produced by the presence of an imperfectly conducting ground of transmission lines in a transient state. A broad range analysis of three of the most often used ground-return models for calculating electromagnetic transients of overhead transmission lines is performed in this paper. The behavior of modal propagation in ground is analyzed here into effects of first and second order. Finally, a numerical tool based on relative error images is proposed in this paper as an aid for the analyst engineer to estimate the incurred error by using approximate ground-return models when calculating transients of overhead transmission lines.

  13. Line Strengths of Rovibrational and Rotational Transitions in the X$^2\\Pi$ Ground State of OH

    CERN Document Server

    Brooke, James S A; Western, Colin M; Sneden, Christopher; Afşar, Melike; Li, Gang; Gordon, Iouli E

    2015-01-01

    A new line list including positions and absolute intensities (in the form of Einstein $A$ values and oscillator strengths) has been produced for the OH ground X\\DP\\ state rovibrational (Meinel system) and pure rotational transitions. All possible transitions are included with v$\\primed$ and v$\\Dprimed$ up to 13, and $J$ up to between 9.5 and 59.5, depending on the band. An updated fit to determine molecular constants has been performed, which includes some new rotational data and a simultaneous fitting of all molecular constants. The absolute line intensities are based on a new dipole moment function, which is a combination of two high level ab initio calculations. The calculations show good agreement with an experimental v=1 lifetime, experimental $\\mu_\\mathrm{v}$ values, and $\\Delta$v=2 line intensity ratios from an observed spectrum. To achieve this good agreement, an alteration in the method of converting matrix elements from Hund's case (b) to (a) was made. Partitions sums have been calculated using the ...

  14. Research on positioning of Xi'an ground fissures with InSAR quality map

    Science.gov (United States)

    Xu, Li; Zhao, Chao-ying

    2011-02-01

    Xi'an ground fissure is a typical geo-hazard with nearly half a century history, which have been caused serious damages to roads, building and other civil facilities. Based on the theory of deformation de-correlation of the active ground fissures, this manuscript mainly investigated the positioning method of active ground fissures by analyzing the pseudo-coherence map of adaptively filtered differential interferogram. We took two ERS1 SAR data during 1992-1993 as an example to investigate the active fissures position during this period. Consequently, high consistency between newly detected fissures and the ground fissure map from engineering geological investigation can be achieved.

  15. Development Ground Fault Detecting System for D.C Voltage Line

    Energy Technology Data Exchange (ETDEWEB)

    Kim Taek Soo; Song Ung Il; Gwon, Young Dong; Lee Hyoung Kee [Korea Electric Power Research Institute, Taejon (Korea, Republic of)

    1996-12-31

    It is necessary to keep the security of reliability and to maximize the efficiency of maintenance by prompt detection of a D.C feeder ground fault point at the built ed or a building power plants. At present, the most of the power plants are set up the ground fault indicator lamp in the monitor room. If a ground fault occurs on DC voltage feeder, a current through the ground fault relay is adjusted and the lamps have brightened while the current flows the relay coil. In order to develop such a system, it is analyzed a D.C feeder ground circuit theoretically and studied a principles which can determine ground fault point or a polarity discrimination and a phase discrimination of the line. So, the developed system through this principles can compute a resistance ground fault current and a capacitive ground fault current. It shows that the system can defect a ground fault point or a bad insulated line by measuring a power plant D.C feeder insulation resistance at the un interruptible power status, and therefore the power plant could protect an unexpected service interruption . (author). 18 refs., figs.

  16. Experimental study on sliding shaft lining mechanical mechanisms under ground subsidence conditions

    Institute of Scientific and Technical Information of China (English)

    姚直书; 杨俊杰; 孙文若

    2003-01-01

    Aimed at more than 60 shaft linings damaged in Huaibei, Datun, Xuzhou and Yanzhou mine areas, this paper presents a new type of sliding shaft lining with asphalt blocks sliding layer. By model test, it is obtained that the deformation characteristics and the mechanical mechanisms of the sliding shaft lining under the condition of ground subsidence. The research results provide a testing basis for the sliding shaft lining design. By now, this kind of sliding shaft lining had been applied in 9 shafts in China and Bangladesh.

  17. Precise On-line Position Measurement for Particle Therapy

    CERN Document Server

    Actis, O; König, S

    2014-01-01

    An on-line beam position monitoring and regular beam stability tests are of utmost importance for the Quality Assurance (QA) of the patient treatment at any particle therapy facility. The Gantry${0.5 mm}2$ at the Paul Scherrer Institute uses a strip ionization chamber for the on-line beam position verification. The design of the strip chamber placed in the beam in front of the patient allows for a small beam penumbra in order to achieve a high-quality lateral beam delivery. The detector granularity and the low noise allow the reconstruction of the signals offered by Gantry${0.5 mm}2$ with a precision of about 0.1 mm. The frond-end electronics and the whole data processing sequence have been optimized for minimizing the dead time between the beam applications to about 2 ms: the charge collection is performed in about 1 ms, read-out takes place in 100 $\\mu$s while data verification and logging are completed in less than 1 ms. The sub-millimeter precision of the lateral reconstruction allows the dose inhomogenei...

  18. Two independent methods for mapping the grounding line of an outlet glacier – example from the Astrolabe Glacier, Terre Adélie, Antarctica

    Directory of Open Access Journals (Sweden)

    E. Le Meur

    2013-08-01

    Full Text Available The grounding line is a key element acting on the dynamics of coastal outlet glaciers. Knowing its position accurately is fundamental for both modelling the glacier dynamics and establishing a benchmark to which one can later refer in case of change. Here we map the grounding line of the Astrolabe Glacier in East Antarctica (66°41´ S; 140°05´ E, using hydrostatic and tidal methods. The first method is based on new surface and ice thickness data from which the line of buoyant flotation is found. We compare this hydrostatic map with kinematic GPS measurements of the tidal response of the ice surface. By detecting the transitions where the ice starts to move vertically in response to the tidal forcing we find control points for the grounding line position along GPS profiles. %If it can be shown that the long-term viscous mechanical behaviour of the ice slab validates the hydrostatic approach, mapping the grounding line from the ice supper surface displacements conversely requires correcting for the rigid elastic slab effect that dominates at tidal frequencies. With the help of a 2-dimensional elastic plate model, rigid elastic deviations are computed and applied to these control points. Once the extent of the grounding zone, the kinematic approach is consistent with the hydrostatic map. These two approaches lead us to propose a grounding line for the Astrolabe Glacier that significantly deviates from those obtained so far from satellite imagery.

  19. Influence of damage and basal friction on the grounding line dynamics

    Science.gov (United States)

    Brondex, Julien; Gagliardini, Olivier; Gillet-Chaulet, Fabien; Durand, Gael

    2016-04-01

    The understanding of grounding line dynamics is a major issue in the prediction of future sea level rise due to ice released from polar ice sheets into the ocean. This dynamics is complex and significantly affected by several physical processes not always adequately accounted for in current ice flow models. Among those processes, our study focuses on ice damage and evolving basal friction conditions. Softening of the ice due to damaging processes is known to have a strong impact on its rheology by reducing its viscosity and therefore promoting flow acceleration. Damage creates where shear stresses are high enough which is usually the case at shear margins and in the vicinity of pinning points in contact with ice-shelves. Those areas are known to have a buttressing effect on ice shelves contributing to stabilize the grounding line. We aim at evaluating the extent to which this stabilizing effect is hampered by damaging processes. Several friction laws have been proposed by various author to model the contact between grounded-ice and bedrock. Among them, Coulomb-type friction laws enable to account for reduced friction related to low effective pressure (the ice pressure minus the water pressure). Combining such a friction law to a parametrization of the effective pressure accounting for the fact that the area upstream the grounded line is connected to the ocean, is expected to have a significant impact on the grounding line dynamics. Using the finite-element code Elmer/Ice within which both the Coulomb-type friction law, the effective pressure parametrization and the damage model have been implemented, the goal of this study is to investigate the sensitivity of the grounding line dynamics to damage and to an evolving basal friction. The relative importance between those two processes on the grounding line dynamics is addressed as well.

  20. Actively evolving subglacial conduits and eskers initiate ice shelf channels at an Antarctic grounding line.

    Science.gov (United States)

    Drews, R; Pattyn, F; Hewitt, I J; Ng, F S L; Berger, S; Matsuoka, K; Helm, V; Bergeot, N; Favier, L; Neckel, N

    2017-05-09

    Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood. Here we use ice-penetrating radar data from Roi Baudouin Ice Shelf, East Antarctica, to infer that the morphology of several ice-shelf channels is seeded upstream of the grounding line by large basal obstacles indenting the ice from below. We interpret each obstacle as an esker ridge formed from sediments deposited by subglacial water conduits, and calculate that the eskers' size grows towards the grounding line where deposition rates are maximum. Relict features on the shelf indicate that these linked systems of subglacial conduits and ice-shelf channels have been changing over the past few centuries. Because ice-shelf channels are loci where intense melting occurs to thin an ice shelf, these findings expose a novel link between subglacial drainage, sedimentation and ice-shelf stability.

  1. Coupling Between Microstrip Lines With Finite Width Ground Plane Embedded in Thin Film Circuits

    Science.gov (United States)

    Ponchak, George E.; Dalton, Edan; Tentzeris, Manos M.; Papapolymerou, John

    2003-01-01

    Three-dimensional (3D) interconnects built upon multiple layers of polyimide are required for constructing 3D circuits on CMOS (low resistivity) Si wafers, GaAs, and ceramic substrates. Thin film microstrip lines (TFMS) with finite width ground planes embedded in the polyimide are often used. However, the closely spaced TFMS lines a r e susceptible to high levels of coupling, which degrades circuit performance. In this paper, Finite Difference Time Domain (FDTD) analysis and experimental measurements a r e used to show that the ground planes must be connected by via holes to reduce coupling in both the forward and backward directions. Furthermore, it is shown that coupled microstrip lines establish a slotline type mode between the two ground planes and a dielectric waveguide type mode, and that the via holes recommended here eliminate these two modes.

  2. IMPROVING SOLUTIONS OF EQUIPMENT’S RELIABILITY FOR DETECTION OF GROUNDING LINES

    Directory of Open Access Journals (Sweden)

    PĂCUREANU I.

    2015-12-01

    Full Text Available The paper has three parts, in the first one, is presented the theoretical concepts that refer on the grounding lines fault, the treating mode, and implemented solutions for their detection in electric stations. In the second part is presented the result of the operational reliability analyse in period of 2011 – 2015, as in the final part of the paper are given the conclusions and identified solutions regarding the improving of operational reliability of the protection equipment of detection of grounding lines.

  3. Realization of Resistorless Lossless Positive and Negative Grounded Inductor Simulators Using Single ZC-CCCITA

    Directory of Open Access Journals (Sweden)

    N. Herencsar

    2012-04-01

    Full Text Available This paper is in continuation with the very recent work of Prasad et al. [14], wherein new realizations of grounded and floating positive inductor simulator using current differencing transconductance amplifier (CDTA are reported. The focus of the paper is to provide alternate realizations of lossless, both positive and negative inductor simulators (PIS and NIS in grounded form using z-copy current-controlled current inverting transconductance amplifier (ZC-CCCITA, which can be considered as a derivative of CDTA, wherein the current differencing unit (CDU is reduced to a current-controlled current inverting unit. We demonstrate that only a single ZC-CCCITA and one grounded capacitor are sufficient to realize grounded lossless PIS or NIS. The proposed circuits are resistorless whose parameters can be controlled through the bias currents. The workability of the proposed PIS is validated by SPICE simulations on three RLC prototypes.

  4. On-line, proximate analysis of ground beef directly at a meat grinder outlet.

    Science.gov (United States)

    Isaksson, T; Nilsen, B N; Tøgersen, G; Hammond, R P; Hildrum, K I

    1996-07-01

    The fat, moisture and protein contents of ground beef were determined on-line by a diffuse reflectance near infrared (NIR) spectroscopy instrument at the outlet of a meat grinder. Beef samples in the range of 6.2-21.7% fat, 59.6-72.9% moisture and 18.1-20.7% protein were studied. Calibrations from samples ground with hole diameters of 4, 8, 13 or 19 mm in the grinder plate were validated. In addition, calibrations of combinations of these samples from the different hole diameters were validated. Prediction errors, expressed as root mean square error of cross validation of the beef samples, were 0.73-1.50% for fat, 0.75-1.33% for moisture and 0.23-0.32% for protein, depending on the hole diameter of the grinder plate. Calibrations from samples ground with the smallest hole diameters gave lowest prediction errors. The present prediction error results are only slightly higher compared to reported prediction error results using conventional at- and off-line NIR instruments. It is concluded that the on-line NIR prediction results were acceptable for samples ground with grinder plates of 4, 8 or 13 mm hole diameter.

  5. Characteristic Impedance of a Microstrip-Like Interconnect Line in Presence of Ground Plane Aperture

    Directory of Open Access Journals (Sweden)

    Rohit Sharma

    2007-01-01

    Full Text Available We propose new empirical expressions for the characteristic impedance of a microstrip-like interconnect line in presence of ground plane aperture. The existing characteristic impedance expressions are modified so as to include the effect of the ground plane aperture. The variation in the characteristic impedance vis-à-vis the aperture size is established. The proposed expressions are general and valid for a range of dielectric materials concerning MICs, RFICs, and PCBs. The results are validated by measurements performed on a vector network analyzer.

  6. Single Phase-to-Ground Fault Line Identification and Section Location Method for Non-Effectively Grounded Distribution Systems Based on Signal Injection

    Institute of Scientific and Technical Information of China (English)

    PAN Zhencun; WANG Chengshan; CONG Wei; ZHANG Fan

    2008-01-01

    A diagnostic signal current trace detecting based single phase-to-ground fault line identifica- tion and section location method for non-effectively grounded distribution systems is presented in thisi oaper. A special diagnostic signal current is injected into the fault distribution system, and then it is de- tected at the outlet terminals to identify the fault line and at the sectionalizing or branching point along the fault line to locate the fault section. The method has been put into application in actual distribution network and field experience shows that it can identify the fault line and locate the fault section correctly and effectively.

  7. Analysis of overvoltages in overhead ground wires of extra high voltage (EHV) power transmission line under single-phase-to-ground faults

    NARCIS (Netherlands)

    Dudurych, [No Value; Rosolowski, E

    2000-01-01

    Overhead ground wires (GW) of extra high voltage (EHV) power transmission lines, apart from lightning-induced overvoltage protection are frequently used for carrier-current communication. In this case the ground wires are suspended on insulators, the dielectric strength of which should be sufficient

  8. Fault Line Selection Method Considering Grounding Fault Angle for Distribution Network

    Institute of Scientific and Technical Information of China (English)

    Li Si-bo; Zhao Yu-lin; Li Ji-chang; Sui Tao

    2015-01-01

    In the distribution network system with its neutral point grounding via arc suppression coil, when single-phase grounding fault occurred near zero-crossing point of the phase voltage, the inaccuracy of the line selection always existed in existing methods. According to the characteristics that transient current was different between the fault feeder and other faultless feeders, wavelet transformation was performed on data of the transient current within a power frequency cycle after the fault occurred. Based on different fault angles, wavelet energy in corresponding frequency band was chosen to compare. The result was that wavelet energy in fault feeder was the largest of all, and it was larger than sum of those in other faultless feeders, when the bus broke down, the disparity between each wavelet energy was not significant. Fault line could be selected out by the criterion above. The results of MATLAB/simulink simulation experiment indicated that this method had anti-interference capacity and was feasible.

  9. New Gravity-Derived Grounding Line Depths Highlight Role Bathymetry Plays in Ongoing Greenland Ice Sheet Change

    Science.gov (United States)

    Boghosian, A.; Porter, D. F.; Tinto, K. J.; Bell, R. E.; Cochran, J. R.; Csatho, B. M.

    2014-12-01

    Bathymetry has been a missing piece in understanding ice-ocean interactions of marine-terminating glaciers in Greenland. As bathymetry in fjords often controls the flow of warm water to the terminus of the glacier, and the grounding line depth of the glacier can modulate the effect of this warm water on the glacier. Study of Tracy and Heilprin Glaciers, a pair of neighboring glaciers in northwest Greenland, has indicated that when exposed to similar external forcings, the glacier with the deeper grounding line will retreat more rapidly. The new comprehensive mapping of grounding line depths with Operation IceBridge gravity inversions provides the basis for examining this question for all of Greenland's glaciers. We consider 54 distinct glaciers in our analysis. Grounding line depths for these 54 come from data collected by Operation IceBridge from 2010-2012. New grounding line depths for 36 glaciers are derived from gravity measurements in locations where radar is unable to retrieve grounding line depths. 18 grounding line depths come from CReSIS Multichannel Coherent Depth Sounder radar data. Offshore bathymetry in all 54 fjords is gravity-derived. The gravity-derived bathymetry is always constrained onshore by radar, and when possible pinned offshore to acoustic bathymetric measurements.Here we present the gravity-derived grounding line depths along with recent glacier behavior, including surface lowering and terminus retreat, of these 54 glaciers. In general, the glaciers with deeper grounding lines are experiencing greater mass loss. This relationship between grounding line depth and mass balance extends to much of Greenland. We systematically discuss this relationship in the different major regions of Greenland, and note that the relationship is strongest in the southeast, and weakest in the north.

  10. Seismic Response of Power Transmission Tower-Line System Subjected to Spatially Varying Ground Motions

    Directory of Open Access Journals (Sweden)

    Li Tian

    2010-01-01

    Full Text Available The behavior of power transmission tower-line system subjected to spatially varying base excitations is studied in this paper. The transmission towers are modeled by beam elements while the transmission lines are modeled by cable elements that account for the nonlinear geometry of the cables. The real multistation data from SMART-1 are used to analyze the system response subjected to spatially varying ground motions. The seismic input waves for vertical and horizontal ground motions are also generated based on the Code for Design of Seismic of Electrical Installations. Both the incoherency of seismic waves and wave travel effects are accounted for. The nonlinear time history analytical method is used in the analysis. The effects of boundary conditions, ground motion spatial variations, the incident angle of the seismic wave, coherency loss, and wave travel on the system are investigated. The results show that the uniform ground motion at all supports of system does not provide the most critical case for the response calculations.

  11. A three-dimensional full Stokes model of the grounding line dynamics: effect of a pinning point beneath the ice shelf

    Directory of Open Access Journals (Sweden)

    L. Favier

    2012-01-01

    Full Text Available The West Antarctic ice sheet is confined by a large area of ice shelves, fed by inland ice through fast flowing ice streams. The dynamics of the grounding line, which is the line-boundary between grounded ice and the downstream ice shelf, has a major influence on the dynamics of the whole ice sheet. However, most ice sheet models use simplifications of the flow equations, as they do not include all the stress components, and are known to fail in their representation of the grounding line dynamics. Here, we present a 3-D full Stokes model of a marine ice sheet, in which the flow problem is coupled with the evolution of the upper and lower free surfaces, and the position of the grounding line is determined by solving a contact problem between the shelf/sheet lower surface and the bedrock. Simulations are performed using the open-source finite-element code Elmer/Ice within a parallel environment. The model's ability to cope with a curved grounding line and the effect of a pinning point beneath the ice shelf are investigated through prognostic simulations. Starting from a steady state, the sea level is slightly decreased to create a contact point between a seamount and the ice shelf. The model predicts a dramatic decrease of the shelf velocities, leading to an advance of the grounding line until both grounded zones merge together, during which an ice rumple forms above the contact area at the pinning point. Finally, we show that once the contact is created, increasing the sea level to its initial value does not release the pinning point and has no effect on the ice dynamics, indicating a stabilising effect of pinning points.

  12. The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets.

    Science.gov (United States)

    Cooper, Scott T; Richters, Karl E; Melin, Travis E; Liu, Zhi-jian; Hordyk, Peter J; Benrud, Ryan R; Geiser, Lauren R; Cash, Steve E; Simon Shelley, C; Howard, David R; Ereth, Mark H; Sola-Visner, Martha C

    2012-05-15

    Hibernating mammals have developed many physiological adaptations to extreme environments. During hibernation, 13-lined ground squirrels (Ictidomys tridecemlineatus) must suppress hemostasis to survive prolonged body temperatures of 4-8°C and 3-5 heartbeats per minute without forming lethal clots. Upon arousal in the spring, these ground squirrels must be able to quickly restore normal clotting activity to avoid bleeding. Here we show that ground squirrel platelets stored in vivo at 4-8°C were released back into the blood within 2 h of arousal in the spring with a body temperature of 37°C but were not rapidly cleared from circulation. These released platelets were capable of forming stable clots and remained in circulation for at least 2 days before newly synthesized platelets were detected. Transfusion of autologous platelets stored at 4°C or 37°C showed the same clearance rates in ground squirrels, whereas rat platelets stored in the cold had a 140-fold increase in clearance rate. Our results demonstrate that ground squirrel platelets appear to be resistant to the platelet cold storage lesions observed in other mammals, allowing prolonged storage in cold stasis and preventing rapid clearance upon spring arousal. Elucidating these adaptations could lead to the development of methods to store human platelets in the cold, extending their shelf life.

  13. Position-space cuts for Wilson line correlators

    NARCIS (Netherlands)

    Laenen, Eric; Larsen, Kasper J.; Rietkerk, Robbert

    2015-01-01

    We further develop the formalism for taking position-space cuts of eikonal diagrams introduced in ref. [1]. These cuts are applied directly to the position-space representation of any such diagram and compute its discontinuity to the leading order in the dimensional regulator. We provide algorithms

  14. Position-space cuts for Wilson line correlators

    NARCIS (Netherlands)

    Laenen, Eric; Larsen, Kasper J.; Rietkerk, Robbert

    2015-01-01

    We further develop the formalism for taking position-space cuts of eikonal diagrams introduced in ref. [1]. These cuts are applied directly to the position-space representation of any such diagram and compute its discontinuity to the leading order in the dimensional regulator. We provide algorithms

  15. Analysis of ground fault current distribution along nonuniform multi-section lines

    Energy Technology Data Exchange (ETDEWEB)

    Buccheri, P.L.; Mangione, S. [Department of Electrical, Electronic and Telecommunication Engineering, Universita degli Studi di Palermo, Viale delle Scienze, 90128 Palermo (Italy)

    2008-09-15

    In case of a substation supplied by a combined overhead-cable line, most of the ground fault current flows through the cable sheaths and discharges into the soil surrounding the point of discontinuity, where cables are connected to the overhead line. In the paper a new method is presented for computing the ground fault current distribution in case of feeding line consisting of two or more different sections, i.e. part overhead and part underground cable. Besides the calculation of the earth current at the fault location, the leakage current at the transit/transition stations as well as at the overhead line towers can be evaluated, in order to ensure proper safety conditions. Based on the two-port theory, the method allows to take into account all the relevant conductively and inductively coupled parameters which take part to the fault current distribution. A computer program based on the proposed method has been developed and some application examples are reported. (author)

  16. POSITIVE SOLUTIONS FOR SINGULAR BVPs ON THE POSITIVE HALF-LINE ARISING FROM EPIDEMIOLOGY AND COMBUSTION THEORY

    Institute of Scientific and Technical Information of China (English)

    Smail Djebali; Ouiza Saifi; Yan Baoqiang

    2012-01-01

    In this work,we are concerned with the existence and multiplicity of positive solutions for singular boundary value problems on the half-line.Two problems from epidemiology and combustion theory set on the positive half-line are investigated.We use upper and lower solution techniques combined with fixed point index on cones in appropriate Banach spaces.The results complement recent ones in the literature.

  17. Position-space cuts for Wilson line correlators

    CERN Document Server

    Laenen, Eric; Rietkerk, Robbert

    2015-01-01

    We further develop the formalism for taking position-space cuts of eikonal diagrams introduced in [Phys.Rev.Lett. 114 (2015), no. 18 181602, arXiv:1410.5681]. These cuts are applied directly to the position-space representation of any such diagram and compute its discontinuity to the leading order in the dimensional regulator. We provide algorithms for computing the position-space cuts and apply them to several two- and three-loop eikonal diagrams, finding agreement with results previously obtained in the literature. We discuss a non-trivial interplay between the cutting prescription and non-Abelian exponentiation. We furthermore discuss the relation of the imaginary part of the cusp anomalous dimension to the static interquark potential.

  18. The on-line electric vehicle wireless electric ground transportation systems

    CERN Document Server

    Cho, Dong

    2017-01-01

    This book details the design and technology of the on-line electric vehicle (OLEV) system and its enabling wireless power-transfer technology, the “shaped magnetic field in resonance” (SMFIR). The text shows how OLEV systems can achieve their three linked important goals: reduction of CO2 produced by ground transportation; improved energy efficiency of ground transportation; and contribution to the amelioration or prevention of climate change and global warming. SMFIR provides power to the OLEV by wireless transmission from underground cables using an alternating magnetic field and the reader learns how this is done. This cable network will in future be part of any local smart grid for energy supply and use thereby exploiting local and renewable energy generation to further its aims. In addition to the technical details involved with design and realization of a fleet of vehicles combined with extensive subsurface charging infrastructure, practical issues such as those involved with pedestrian safety are c...

  19. On proton excitation of forbidden lines in positive ions

    Energy Technology Data Exchange (ETDEWEB)

    Burgess, Alan [Department of Applied Mathematics and Theoretical Physics, Wilberforce Road, Cambridge CB3 0WA (United Kingdom); Tully, John A [Observatoire de la Cote d' Azur, Departement Cassiopee, BP 4229, 06304 Nice Cedex 4 (France)

    2005-08-14

    The semi-classical impact parameter approximations used by Bahcall and Wolf and by Bely and Faucher, for proton excitation of electric quadrupole transitions in positive ions, both fail at high energies, giving cross sections which do not fall off correctly as constant/E. This is in contrast with the pioneering example of Seaton for Fe{sup +13} and of Reid and Schwarz for S{sup +3}, both of whom achieve the correct functional form, but do not ensure the correct constant of proportionality. By combining the Born and semi-classical approximations one can obtain cross sections which have the full correct behaviour as E {yields} {infinity}, and hence, rate coefficients which have the correct high temperature behaviour ({approx}C/T{sup 1/2} with the correct value of C). We provide a computer program for calculating these. An error in Faucher's derivation of the Born formula is also discussed.

  20. Ground-based observation of emission lines from the corona of a red-dwarf star.

    Science.gov (United States)

    Schmitt, J H; Wichmann, R

    2001-08-02

    All 'solar-like' stars are surrounded by coronae, which contain magnetically confined plasma at temperatures above 106 K. (Until now, only the Sun's corona could be observed in the optical-as a shimmering envelope during a total solar eclipse.) As the underlying stellar 'surfaces'-the photospheres-are much cooler, some non-radiative process must be responsible for heating the coronae. The heating mechanism is generally thought to be magnetic in origin, but is not yet understood even for the case of the Sun. Ultraviolet emission lines first led to the discovery of the enormous temperature of the Sun's corona, but thermal emission from the coronae of other stars has hitherto been detectable only from space, at X-ray wavelengths. Here we report the detection of emission from highly ionized iron (Fe XIII at 3,388.1 A) in the corona of the red-dwarf star CN Leonis, using a ground-based telescope. The X-ray flux inferred from our data is consistent with previously measured X-ray fluxes, and the non-thermal line width of 18.4 km s-1 indicates great similarities between solar and stellar coronal heating mechanisms. The accessibility and spectral resolution (45,000) of the ground-based instrument are much better than those of X-ray satellites, so a new window to the study of stellar coronae has been opened.

  1. Evidence of transverse magnetospheric field line oscillations as observed from Cluster and ground magnetometers

    Directory of Open Access Journals (Sweden)

    A. K. Sinha

    2005-03-01

    Full Text Available The dynamic spectrum of ULF waves from magnetic field data obtained by the elliptically orbiting Cluster satellites (with an apogee of 119000km, perigee of 19000km and the orbital period of 57h have been prepared in the frequency range 0 to 120mHz when the satellite was near its perigee. The existence of field line oscillations, with increasing frequency in the inbound sector and decreasing frequency in the outbound sector, is seen in the transverse components, indicating the presence of independently oscillating local magnetic flux tubes in the form of transverse standing Alfvén waves. The results show that toroidal and poloidal modes are excited simultaneously. The analysis of simultaneous ground magnetometer data at the footprint of the satellite suggests that these modes are also excited due to coupling to magnetospheric waveguide modes. The clear signature of a resonant fundamental mode is seen in the ground data whereas Cluster detects a harmonic of this frequency. Lower frequency modes indicative of waveguide oscillations are seen in both the ground data and the compressional field at Cluster.

  2. Charge structure analysis of a severe hailstorm with predominantly positive cloud-to-ground lightning

    Science.gov (United States)

    Pineda, Nicolau; Rigo, Tomeu; Montanyà, Joan; van der Velde, Oscar A.

    2016-09-01

    The present study makes use of cloud-to-ground lightning, three-dimensional mapping from a Lightning Mapping Array and Doppler C-band radar observations to analyze the lightning trends and the underlying electrical charge structure of a large-hail bearing storm that produced important damages on the local agriculture. The analysis reported an extremely active storm, evolving through distinct phases, which stood out from a multicell structure to finally become a supercell. The onset of newer regions of convective development interacting with the main cell made the charge structure to be rather complex during some stages of this long-lived hailstorm. Evidence suggests the presence of regions with the charge layer being inverted from that of normal, non-severe convective storms, producing predominantly positive cloud-to-ground lightning. The analysis also suggests that strong cloud signals were misclassified as low peak current single-stroke negative cloud-to-ground flashes, masking the predominant positive nature of the storm.

  3. A Novel High-Frequency Voltage Standing-Wave Ratio-Based Grounding Electrode Line Fault Supervision in Ultra-High Voltage DC Transmission Systems

    Directory of Open Access Journals (Sweden)

    Yufei Teng

    2017-03-01

    Full Text Available In order to improve the fault monitoring performance of grounding electrode lines in ultra-high voltage DC (UHVDC transmission systems, a novel fault monitoring approach based on the high-frequency voltage standing-wave ratio (VSWR is proposed in this paper. The VSWR is defined considering a lossless transmission line, and the characteristics of the VSWR under different conditions are analyzed. It is shown that the VSWR equals 1 when the terminal resistance completely matches the characteristic impedance of the line, and when a short circuit fault occurs on the grounding electrode line, the VSWR will be greater than 1. The VSWR will approach positive infinity under metallic earth fault conditions, whereas the VSWR in non-metallic earth faults will be smaller. Based on these analytical results, a fault supervision criterion is formulated. The effectiveness of the proposed VSWR-based fault supervision technique is verified with a typical UHVDC project established in Power Systems Computer Aided Design/Electromagnetic Transients including DC(PSCAD/EMTDC. Simulation results indicate that the proposed strategy can reliably identify the grounding electrode line fault and has strong anti-fault resistance capability.

  4. Limited grounding-line advance onto the West Antarctic continental shelf in the easternmost Amundsen Sea Embayment during the last glacial period.

    Science.gov (United States)

    Klages, Johann P; Kuhn, Gerhard; Hillenbrand, Claus-Dieter; Smith, James A; Graham, Alastair G C; Nitsche, Frank O; Frederichs, Thomas; Jernas, Patrycja E; Gohl, Karsten; Wacker, Lukas

    2017-01-01

    Precise knowledge about the extent of the West Antarctic Ice Sheet (WAIS) at the Last Glacial Maximum (LGM; c. 26.5-19 cal. ka BP) is important in order to 1) improve paleo-ice sheet reconstructions, 2) provide a robust empirical framework for calibrating paleo-ice sheet models, and 3) locate potential shelf refugia for Antarctic benthos during the last glacial period. However, reliable reconstructions are still lacking for many WAIS sectors, particularly for key areas on the outer continental shelf, where the LGM-ice sheet is assumed to have terminated. In many areas of the outer continental shelf around Antarctica, direct geological data for the presence or absence of grounded ice during the LGM is lacking because of post-LGM iceberg scouring. This also applies to most of the outer continental shelf in the Amundsen Sea. Here we present detailed marine geophysical and new geological data documenting a sequence of glaciomarine sediments up to ~12 m thick within the deep outer portion of Abbot Trough, a palaeo-ice stream trough on the outer shelf of the Amundsen Sea Embayment. The upper 2-3 meters of this sediment drape contain calcareous foraminifera of Holocene and (pre-)LGM age and, in combination with palaeomagnetic age constraints, indicate that continuous glaciomarine deposition persisted here since well before the LGM, possibly even since the last interglacial period. Our data therefore indicate that the LGM grounding line, whose exact location was previously uncertain, did not reach the shelf edge everywhere in the Amundsen Sea. The LGM grounding line position coincides with the crest of a distinct grounding-zone wedge ~100 km inland from the continental shelf edge. Thus, an area of ≥6000 km2 remained free of grounded ice through the last glacial cycle, requiring the LGM grounding line position to be re-located in this sector, and suggesting a new site at which Antarctic shelf benthos may have survived the last glacial period.

  5. Response of a transmission tower-line system at a canyon site to spatially varying ground motions

    Institute of Scientific and Technical Information of China (English)

    Hong-nan LI; Feng-long BAI; Li TIAN; Hong HAO

    2011-01-01

    Collapses of transmission towers were often observed in previous large earthquakes such as the Chi-Chi earthquake in Taiwan and Wenchuan earthquake in Sichuan, China. These collapses were partially caused by the pulling forces from the transmission lines generated from out-of-phase responses of the adjacent towers owing to spatially varying earthquake ground motions. In this paper, a 3D finite element model of the transmission tower-line system is established considering the geometric nonlinearity of transmission lines. The nonlinear responses of the structural system at a canyon site are analyzed subjected to spatially varying ground motions. The spatial variations of ground motion associated with the wave passage, coherency loss, and local site effects are given. The spatially varying ground motions are simulated stochastically based on an empirical coherency loss function and a filtered Tajimi-Kanai power spectral density function. The site effect is considered by a transfer function derived from ID wave propagation theory. Compared with structural responses calculated using the uniform ground motion and delayed excitations, numerical results indicate that seismic responses of transmission towers and power lines are amplified when considering spatially varying ground motions including site effects. Each factor of ground motion spatial variations has a significant effect on the seismic response of the structure, especially for the local site effect. Therefore, neglecting the earthquake ground motion spatial variations may lead to a substantial underestimation of the response of transmission tower-line system during strong earthquakes. Each effect of ground motion spatial variations should be incorporated in seismic analysis of the structural system.

  6. The Way of Reducing Current Values in Optical Ground Wires at Asymmetrical Faults on Overhead Transmission Lines

    Directory of Open Access Journals (Sweden)

    Egamnazarov Georgiy

    2016-12-01

    Full Text Available Given the fact that the installing costs of an optical ground wire on overhead lines directly depend on its cross-section, which in turn depends on the level of fault current it should withstand, in order to reduce these current values in the optical ground wire, I suggested performing its isolated descents from the end towers of the line with its transition to an optical cable. The research was carried out on the example of a 500 kV overhead line in the National Electric Power Grid. The Method of Symmetrical Components for calculating asymmetrical fault currents was not used; therefore, calculations were carried out on the base of presenting the line as a multi-wire system for the considered case as a five-wire system (optical ground wire, steel ground wire, and three phase wires. Such approach allows taking into account the initial asymmetry of the line parameters and modeling any kind of asymmetrical faults. The analyses of calculated results were performed. The conclusive evidence that the optical ground wire isolated descents from the end towers of the line give the possibility of reducing the level of maximal fault current distribution values in it and therefore its cross section, is presented.

  7. Positive ground state solutions to Schrodinger-Poisson systems with a negative non-local term

    Directory of Open Access Journals (Sweden)

    Yan-Ping Gao

    2015-04-01

    Full Text Available In this article, we study the Schrodinger-Poisson system $$\\displaylines{ -\\Delta u+u-\\lambda K(x\\phi(xu=a(x|u|^{p-1}u, \\quad x\\in\\mathbb{R}^3, \\cr -\\Delta\\phi=K(xu^{2},\\quad x\\in\\mathbb{R}^3, }$$ with $p\\in(1,5$. Assume that $a:\\mathbb{R}^3\\to \\mathbb{R^{+}}$ and $K:\\mathbb{R}^3\\to \\mathbb{R^{+}}$ are nonnegative functions and satisfy suitable assumptions, but not requiring any symmetry property on them, we prove the existence of a positive ground state solution resolved by the variational methods.

  8. Wire position system to consistently measure and record the location change of girders following ground changes

    Science.gov (United States)

    Choi, H. J.; Lee, S. B.; Lee, H. G.; Y Back, S.; Kim, S. H.; Kang, H. S.

    2017-07-01

    Several parts that comprise the large scientific device should be installed and operated at the accurate three-dimensional location coordinates (X, Y, and Z) where they should be subjected to survey and alignment. The location of the aligned parts should not be changed in order to ensure that the electron beam parameters (Energy 10 GeV, Charge 200 pC, and Bunch Length 60 fs, Emittance X/Y 0.481 μm/0.256 μm) of PAL-XFEL (X-ray Free Electron Laser of the Pohang Accelerator Laboratory) remain stable and can be operated without any problems. As time goes by, however, the ground goes through uplift and subsidence, which consequently deforms building floors. The deformation of the ground and buildings changes the location of several devices including magnets and RF accelerator tubes, which eventually leads to alignment errors (∆X, ∆Y, and ∆Z). Once alignment errors occur with regard to these parts, the electron beam deviates from its course and beam parameters change accordingly. PAL-XFEL has installed the Hydrostatic Leveling System (HLS) to measure and record the vertical change of buildings and ground consistently and systematically and the Wire Position System (WPS) to measure the two dimensional changes of girders. This paper is designed to introduce the operating principle and design concept of WPS and discuss the current situation regarding installation and operation.

  9. Ground-to-air flow visualization using Solar Calcium-K line Background-Oriented Schlieren

    Science.gov (United States)

    Hill, Michael A.; Haering, Edward A.

    2017-01-01

    The Calcium-K Eclipse Background-Oriented Schlieren experiment was performed as a proof of concept test to evaluate the effectiveness of using the solar disk as a background to perform the Background-Oriented Schlieren (BOS) method of flow visualization. A ground-based imaging system was equipped with a Calcium-K line optical etalon filter to enable the use of the chromosphere of the sun as the irregular background to be used for BOS. A US Air Force T-38 aircraft performed three supersonic runs which eclipsed the sun as viewed from the imaging system. The images were successfully post-processed using optical flow methods to qualitatively reveal the density gradients in the flow around the aircraft.

  10. High basal melting forming a channel at the grounding line of Ross Ice Shelf, Antarctica

    Science.gov (United States)

    Marsh, Oliver J.; Fricker, Helen A.; Siegfried, Matthew R.; Christianson, Knut; Nicholls, Keith W.; Corr, Hugh F. J.; Catania, Ginny

    2016-01-01

    Antarctica's ice shelves are thinning at an increasing rate, affecting their buttressing ability. Channels in the ice shelf base unevenly distribute melting, and their evolution provides insight into changing subglacial and oceanic conditions. Here we used phase-sensitive radar measurements to estimate basal melt rates in a channel beneath the currently stable Ross Ice Shelf. Melt rates of 22.2 ± 0.2 m a-1 (>2500% the overall background rate) were observed 1.7 km seaward of Mercer/Whillans Ice Stream grounding line, close to where subglacial water discharge is expected. Laser altimetry shows a corresponding, steadily deepening surface channel. Two relict channels to the north suggest recent subglacial drainage reorganization beneath Whillans Ice Stream approximately coincident with the shutdown of Kamb Ice Stream. This rapid channel formation implies that shifts in subglacial hydrology may impact ice shelf stability.

  11. Autonomous Inspection Robot for Power Transmission Lines Maintenance While Operating on the Overhead Ground Wires

    Directory of Open Access Journals (Sweden)

    Zheng Li

    2011-01-01

    Full Text Available This paper describes the development of a mobile robot capable of clearing such obstacles as counterweights, anchor clamps, and torsion tower. The mobile robot walks on overhead ground wires in 500KV power tower. Its ultimate purpose is to automate to inspect the defect of power transmission line. The robot with 13 motors is composed of two arms, two wheels, two claws, two wrists, etc. Each arm has 4 degree of freedom. Claws are also mounted on the arms. An embedded computer based on PC/104 is chosen as the core of control system. Visible light and thermal infrared cameras are installed to obtain the video and temperature information, and the communication system is based on wireless LAN TCP/IP protocol. A prototype robot was developed with careful considerations of mobility. The new sensor configuration is used for the claw to grasp the overhead ground wires. The bridge is installed in the torsion tower for the robot easy to cross obstacles. The new posture plan is proposed for obstacles cleaning in the torsion tower. Results of experiments demonstrate that the robot can be applied to execute the navigation and inspection tasks.

  12. High-resolution absorption spectroscopy of the OH 2Pi 3/2 ground state line

    CERN Document Server

    Wiesemeyer, Helmut; Heyminck, Stefan; Karl, Jacobs; Menten, Karl; Neufeld, David; Requena-Torres, Miguel Angel; Stutzki, Jürgen; 10.1051/0004-6361/201218915

    2012-01-01

    The chemical composition of the interstellar medium is determined by gas phase chemistry, assisted by grain surface reactions, and by shock chemistry. The aim of this study is to measure the abundance of the hydroxyl radical (OH) in diffuse spiral arm clouds as a contribution to our understanding of the underlying network of chemical reactions. Owing to their high critical density, the ground states of light hydrides provide a tool to directly estimate column densities by means of absorption spectroscopy against bright background sources. We observed onboard the SOFIA observatory the 2Pi3/2, J = 5/2 3/2 2.5 THz line of ground-state OH in the diffuse clouds of the Carina-Sagittarius spiral arm. OH column densities in the spiral arm clouds along the sightlines to W49N, W51 and G34.26+0.15 were found to be of the order of 10^14 cm^-2, which corresponds to a fractional abundance of 10^-7 to 10^-8, which is comparable to that of H_2O. The absorption spectra of both species have similar velocity components, and the...

  13. Autonomous Inspection Robot for Power Transmission Lines Maintenance While Operating on the Overhead Ground Wires

    Directory of Open Access Journals (Sweden)

    Zheng Li

    2010-12-01

    Full Text Available This paper describes the development of a mobile robot capable of clearing such obstacles as counterweights, anchor clamps, and torsion tower. The mobile robot walks on overhead ground wires in 500KV power tower. Its ultimate purpose is to automate to inspect the defect of power transmission line. The robot with 13 motors is composed of two arms, two wheels, two claws, two wrists, etc. Each arm has 4 degree of freedom. Claws are also mounted on the arms. An embedded computer based on PC/104 is chosen as the core of control system. Visible light and thermal infrared cameras are installed to obtain the video and temperature information, and the communication system is based on wireless LAN TCP/IP protocol. A prototype robot was developed with careful considerations of mobility. The new sensor configuration is used for the claw to grasp the overhead ground wires. The bridge is installed in the torsion tower for the robot easy to cross obstacles. The new posture plan is proposed for obstacles cleaning in the torsion tower. Results of experiments demonstrate that the robot can be applied to execute the navigation and inspection tasks.

  14. Accuracy of WAAS-enabled GPS for the determination of position and speed over ground.

    Science.gov (United States)

    Witte, T H; Wilson, A M

    2005-08-01

    The Global Positioning System (GPS) offers many advantages over conventional methods for the determination of subject speed during biomechanical studies. Recent advances in GPS technology, in particular the implementation of the Wide-Angle Augmentation System and European Geostationary Navigation Overlay Service (WAAS/EGNOS), mean that small, highly portable units are available offering the potential of superior accuracy in the determination of both position and speed. This study set out to examine the accuracy of a WAAS-enabled GPS unit for the determination of position and speed. Comparison with the new and published data showed significant enhancements in both position and speed accuracy over a non-WAAS system. Position data collected during straight line cycling showed significantly lower sample-to-sample variation (mean absolute deviation from straight line 0.11 vs. 0.78 m) and greater repeatability from trial to trial (mean absolute deviation from actual path 0.37 vs. 4.8 m) for the WAAS-enabled unit compared to the non-WAAS unit. The speed determined by the WAAS-enabled GPS receiver during cycling in a straight line was within 0.2 ms(-1) of the actual speed measured for 57% of the values with 82% lying within 0.4 ms(-1), however, the data tended towards underestimation of speed during circle cycling, with 65% of values within 0.2 ms(-1) and 87% within 0.4 ms(-1) of the actual value. Local dGPS and dual frequency techniques are more accurate still, however, traditional differential GPS (dGPS), employing FM radio transmission of correction data to a separate receiver, now offers no advantage over WAAS and appears redundant.

  15. Reference Sphere Positioning Measurement Based on Line-Structured Light Vision Sensor

    OpenAIRE

    2013-01-01

    The line-structured light vision sensor has been used widely in industrial vision measuring fields due to its simple structure, small volume, light weight, low cost, convenient calibration, and high accuracy of measurement. To locate the reference sphere precisely with line-structured light vision sensor, a mathematical model based on the measuring principle of line-structured light vision sensor is established in the paper. Then, the positioning measurement error is analyzed in detail. The e...

  16. Characteristics of Preliminary Breakdown Pulses in Positive Ground Flashes during Summer Thunderstorms in Sweden

    Directory of Open Access Journals (Sweden)

    Dalina Johari

    2016-03-01

    Full Text Available This paper presents the characteristics of the preliminary breakdown pulses (PBP in 51 positive ground flashes recorded during 2014 summer thunderstorms in Sweden. Electric field measurements were conducted remotely using a broadband antenna system (up to 100 MHz for a recording length of 1 s with 200 ms trigger time. In the analysis, PBP trains were observed in 86% of the cases. Based on the number of trains preceding the first return stroke, the PBP were classified into single and multiple train PBP. Characteristics of the first PBP train were determined and based on the initial polarity of the pulses, three types of PBP were identified. Characteristics of the subsequent PBP trains in the multiple train PBP were also analyzed and they were compared with the first PBP train. Based on the conceptual charge cloud configuration, we found that the inverted dipole is consistent with our observation. We also found that PBP in positive ground flashes during summer thunderstorms in Sweden are weak since the average ratios of the PBP peak to the first return stroke peak lie only between 0.21 and 0.26. Possible reasons for no detection of PBP and the different types of PBP observed were also discussed.

  17. Untangling positive and negative biotic interactions: views from above and below ground in a forest ecosystem.

    Science.gov (United States)

    Montgomery, Rebecca A; Reich, Peter B; Palik, Brian J

    2010-12-01

    In ecological communities, the outcome of plant-plant interactions represents the net effect of positive and negative interactions occurring above and below ground. Untangling these complex relationships can provide a better understanding of mechanisms that underlie plant-plant interactions and enhance our ability to predict population, community, and ecosystem effects of biotic interactions. In forested ecosystems, tree seedlings interact with established vegetation, but the mechanisms and outcomes of these interactions are not well understood. To explore such mechanisms, we manipulated above- and belowground interactions among tree seedlings, shrubs, and trees and monitored seedling survival and growth of six species (Pinus banksiana, Betula papyrifera, P. resinosa, Quercus rubra, P. strobus, and Acer rubrum) in mature pine-dominated forest in northern Minnesota, USA. The forest had a moderately open canopy and sandy soils. Understory manipulations were implemented in the forest interior and in large gaps and included removal of shrubs (no interactions), tieback of shrubs (belowground), removal of shrubs with addition of shade (aboveground), and unmanipulated shrubs (both below- and aboveground). We found that shrubs either suppressed or facilitated seedling survival and growth depending on the seedling species, source of interaction (e.g., above- or belowground), and ecological context (e.g., gap or forest interior). In general, shrubs strongly influenced survival and growth in gaps, with more modest effects in the forest interior. In gaps, the presence of shrub roots markedly decreased seedling growth and survival, supporting the idea that belowground competition may be more important in dry, nutrient-poor sites. Shrub shade effects were neutral for three species and facilitative for the other three. Facilitation was more likely for shade-tolerant species. In the forest interior, shrub shade negatively affected seedling survival for the most shade

  18. Full-Stokes modeling of grounding line dynamics, ice melt and iceberg calving for Thwaites Glacier, West Antarctica

    OpenAIRE

    Yu, Hongju; Rignot, Eric; Morlighem, Mathieu; Seroussi, Helene

    2016-01-01

    Thwaites Glacier (TG), West Antarctica, has been losing mass and retreating rapidly in the past three decades. Here we present a two-dimensional, Full-Stokes (FS) modeling study of the grounding line dynamics and iceberg calving of TG. First, we compare FS with two simplified models, the higher-order (HO) model and the shallow-shelf approximation (SSA) model, to determine the impact of changes in ice shelf basal melt rate on grounding line dynamics. Second, we combine FS with the Linear Elast...

  19. Coupling Between Microstrip Lines with Finite Width Ground Plane Embedded in Polyimide Layers for 3D-MMICs on Si

    Science.gov (United States)

    Ponchak, George E.; Dalton, Edan; Tentzeris, Emmanouil M.; Papapolymerou, John; Williams, W. Dan (Technical Monitor)

    2001-01-01

    Three-dimensional circuits built upon multiple layers of polyimide are required for constructing Si/SiGe monolithic microwave/millimeter-wave integrated circuits on complementary metal oxide semiconductor (CMOS) (low resistivity) Si wafers. Thin film microstrip lines (TFMS) with finite width ground planes embedded in the polyimide are often used. However, the closely spaced TFMS lines are susceptible to high levels of coupling, which degrades circuit performance. In this paper, Finite Difference Time Domain (FDTD) analysis and experimental measurements are used to show that the ground planes must be connected by via holes to reduce coupling in both the forward and backward directions.

  20. New fault location system for power transmission lines using composite fiber-optic overhead ground wire (OPGW)

    Energy Technology Data Exchange (ETDEWEB)

    Urasawa, K. (Tokyo Electric Power Co., Inc. (Japan)); Kanemaru, K.; Toyota, S.; Sugiyama, K. (Hitachi Cable, Ltd., Tokyo (Japan))

    1989-10-01

    A new fault location (FL) method using composite fiber-optic overhead ground wires (OPGWs) is developed to find out where electrical faults occur on overhead power transmission lines. This method locates the fault section by detecting the current induced in the ground wire (GW), i.e. OPGW in this system. Since detected fault information is essentially uncertain, the new FL method treats the fault information oas a current distribution pattern throughout the power line, and applies Fuzzy Theory to realize the human-like manner of fault location used by electrical power engineers. It was confirmed by computer simulations that the fault section can be accurately located using this method under various conditions. This FL system has already been applied to several commercial power transmission lines and successfully located the sections where electrical faults occurred on actual power transmission lines.

  1. Pseudo-field line resonances in ground Pc5 pulsation events

    Directory of Open Access Journals (Sweden)

    D. V. Sarafopoulos

    2005-02-01

    Full Text Available In this work we study four representative cases of Pc5 ground pulsation events with discrete and remarkably stable frequencies extended at least in a high-latitude range of ~20°; a feature that erroneously gives the impression for an oscillation mode with "one resonant field line". Additionally, the presented events show characteristic changes in polarization sense, for a meridian chain of stations from the IMAGE array, and maximize their amplitude at or close to the supposed resonant magnetic field shell, much like the typical FLR. Nevertheless, they are not authentic FLRs, but pseudo-FLRs, as they are called. These structures are produced by repetitive and tilted twin-vortex structures caused by magnetopause surface waves, which are probably imposed by solar wind pressure waves. The latter is confirmed with in-situ measurements obtained by the Cluster satellites, as well as the Geotail, Wind, ACE, and LANL 1994-084 satellites. This research effort is largely based on two recent works: first, Sarafopoulos (2004a has observationally established that a solar wind pressure pulse (stepwise pressure variation produces a twin-vortex (single vortex current system over the ionosphere; second, Sarafopoulos (2004b has studied ground events with characteristic dispersive latitude-dependent structures and showed that these are associated with twin-vortex ionosphere current systems. In this work, we show that each pseudo-FLR event is associated with successive and tilted large-scale twin-vortex current systems corresponding to a magnetopause surface wave with wavelength 10-20RE. We infer that between an authentic FLR, which is a spatially localized structure with an extent 0.5RE in the magnetospheric equatorial plane, and the magnetopause surface wavelength, there is a scale factor of 20-40. A chief observational finding, in this work, is that there are Pc5 ground pulsation events showing two gradual and latitude

  2. Kinematic Geometry for the Saddle Line Fitting of Planar Discrete Positions

    Institute of Scientific and Technical Information of China (English)

    WU Yu; WANG Delun; WANG Wei; YU Shudong; XU Wenji

    2015-01-01

    The position synthesis of planar linkages is to locate the center point of the moving joint on a rigid link, whose trajectory is a circle or a straight line. Utilizing the min-max optimization scheme, the fitting curve needs to minimize the maximum fitting error to acquire the dimension of a planar binary P-R link. Based on the saddle point programming, the fitting straight line is determined to the planar discrete point-path traced by the point of the rigid body in planar motion. The property and evolution of the defined saddle line error can be revealed from three given separate points. A quartic algebraic equation relating the fitting error and the coordinates is derived, which agrees with the classical theory. The effect of the fourth point is discussed in three cases through the constraint equations. The multi-position saddle line error is obtained by combination and comparison from the saddle point programming. Several examples are presented to illustrate the solution process for the saddle line error of the moving plane. The saddle line error surface and the contour map presented to show the variations of the fitting error in the fixed frame. The discrete kinematic geometry is then set up to disclose the relations of the separate positions of the rigid body, the location of the tracing point on the moving body, and the position and orientation of the saddle line to the point-path. This paper presents a new analytic geometry method for saddle line fitting and provides a theoretical foundation for position synthesis.

  3. Kinematic geometry for the saddle line fitting of planar discrete positions

    Science.gov (United States)

    Wu, Yu; Wang, Delun; Wang, Wei; Yu, Shudong; Xu, Wenji

    2015-07-01

    The position synthesis of planar linkages is to locate the center point of the moving joint on a rigid link, whose trajectory is a circle or a straight line. Utilizing the min-max optimization scheme, the fitting curve needs to minimize the maximum fitting error to acquire the dimension of a planar binary P-R link. Based on the saddle point programming, the fitting straight line is determined to the planar discrete point-path traced by the point of the rigid body in planar motion. The property and evolution of the defined saddle line error can be revealed from three given separate points. A quartic algebraic equation relating the fitting error and the coordinates is derived, which agrees with the classical theory. The effect of the fourth point is discussed in three cases through the constraint equations. The multi-position saddle line error is obtained by combination and comparison from the saddle point programming. Several examples are presented to illustrate the solution process for the saddle line error of the moving plane. The saddle line error surface and the contour map presented to show the variations of the fitting error in the fixed frame. The discrete kinematic geometry is then set up to disclose the relations of the separate positions of the rigid body, the location of the tracing point on the moving body, and the position and orientation of the saddle line to the point-path. This paper presents a new analytic geometry method for saddle line fitting and provides a theoretical foundation for position synthesis.

  4. The Connemara Fan: a major glacial grounding line fan west of Ireland

    Science.gov (United States)

    McCarron, Stephen; Praeg, Daniel; Monteys, Xavier; Scott, Gill

    2014-05-01

    Glacigenic topography on the mid-shelf (~130-350 m water depth) west of Galway, Ireland appears to have the morphological form, internal architecture and sediments associated with a large glacial grounding-line fan. Seismic data collected in 2009 and 2012 (during the GLAMAR and GATEWAYS 1 campaigns) reveal that the broad, arcuate ridges of the 'Olex moraine' form the landward part of a fan system which prograded beyond the mid-shelf break (defining the outer margin of the 'Clare Platform') westwards into the Porcupine Seabight. The topography is comparable to larger shelf-edge trough-mouth fans found further north along the same margin, however no discernible 'trough' has been identified on the Clare Platform. The ridge and fan topographic assemblage is renamed the 'Connemara Fan' in its entirety, based on its genetic relations and geographic location due west of Connemara, western Ireland. A macrofossil recovered from within a debris flow on the outer fan slope comprised of remobilised plumites dates to ~ 20 ka Cal B.P., indicating sediment reworking downslope following deglacial sediment input to at least that time. The Connemara Fan is the most southerly glacigenic fan identified along the north-east Atlantic margin. Its identification also adds to our knowledge of possibly multiple generations of ice sheets feeding onto the Irish shelf from west-central Ireland and the occurrence of ice sheet geometries and dynamics that evacuated ice, melt-water and sediment (ice streams?) westwards across the Clare Platform during past glaciations.

  5. Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels.

    Directory of Open Access Journals (Sweden)

    Eva Andres-Mateos

    Full Text Available Skeletal muscle atrophy can occur as a consequence of immobilization and/or starvation in the majority of vertebrates studied. In contrast, hibernating mammals are protected against the loss of muscle mass despite long periods of inactivity and lack of food intake. Resident muscle-specific stem cells (satellite cells are known to be activated by muscle injury and their activation contributes to the regeneration of muscle, but whether satellite cells play a role in hibernation is unknown. In the hibernating 13-lined ground squirrel we show that muscles ablated of satellite cells were still protected against atrophy, demonstrating that satellite cells are not involved in the maintenance of skeletal muscle during hibernation. Additionally, hibernating skeletal muscle showed extremely slow regeneration in response to injury, due to repression of satellite cell activation and myoblast differentiation caused by a fine-tuned interplay of p21, myostatin, MAPK, and Wnt signaling pathways. Interestingly, despite long periods of inflammation and lack of efficient regeneration, injured skeletal muscle from hibernating animals did not develop fibrosis and was capable of complete recovery when animals emerged naturally from hibernation. We propose that hibernating squirrels represent a new model system that permits evaluation of impaired skeletal muscle remodeling in the absence of formation of tissue fibrosis.

  6. On line high dose static position monitoring by ionization chamber detector for industrial gamma irradiators.

    Science.gov (United States)

    Rodrigues, Ary A; Vieira, Jose M; Hamada, Margarida M

    2010-01-01

    A 1 cm(3) cylindrical ionization chamber was developed to measure high doses on line during the sample irradiation in static position, in a (60)Co industrial plant. The developed ionization chamber showed to be suitable for use as a dosimeter on line. A good linearity of the detector was found between the dose and the accumulated charge, independently of the different dose rates caused by absorbing materials.

  7. On line high dose static position monitoring by ionization chamber detector for industrial gamma irradiators

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Ary A. [Universidade Estadual de Londrina-Depto de Fisica, Rodovia Celso Garcia Cid, km 38, 086051-990 Londrina (Brazil); Vieira, Jose M. [Instituto de Pesquisas Energeticas e Nucleares-IPEN/CNEN-SP, Prof. Lineu Prestes, 2242-Cidade Universitaria, 05508-900 Sao Paulo (Brazil); Hamada, Margarida M. [Instituto de Pesquisas Energeticas e Nucleares-IPEN/CNEN-SP, Prof. Lineu Prestes, 2242-Cidade Universitaria, 05508-900 Sao Paulo (Brazil)], E-mail: mmhamada@ipen.br

    2010-04-15

    A 1 cm{sup 3} cylindrical ionization chamber was developed to measure high doses on line during the sample irradiation in static position, in a {sup 60}Co industrial plant. The developed ionization chamber showed to be suitable for use as a dosimeter on line. A good linearity of the detector was found between the dose and the accumulated charge, independently of the different dose rates caused by absorbing materials.

  8. ATOMIC DATA FOR ABSORPTION-LINES FROM THE GROUND-LEVEL AT WAVELENGTHS GREATER-THAN-228-ANGSTROM

    NARCIS (Netherlands)

    VERNER, DA; BARTHEL, PD; TYTLER, D

    1994-01-01

    We list wavelengths, statistical weigths and oscillator strengths for 2249 spectral lines arising from the ground states of atoms and ions. The compilation covers all wavelengths longward of the HeII Lyman limit at 227.838 Angstrom and all the ion states of all elements from hydrogen to bismuth (Z =

  9. Initiating an error budget of the DORIS ground antenna position: Genesis of the Starec antenna type C

    Science.gov (United States)

    Saunier, J.; Auriol, A.; Tourain, C.

    2016-12-01

    The DORIS system measures distances between phase centers of onboard and ground antennas to determine the position of the satellites in their orbits. To this end, the ground antenna phase center position must be known in a terrestrial reference frame. Its position is linked and defined with respect to the antenna reference point (ARP), a conventional physical point for which coordinates are assigned. Although the determination of the ARP position with respect to ground markers can be achieved by traditional surveys, the connection with the actual measurement point (phase center) is far more difficult to determine. This is the main concern explored in this paper. Regardless of the need for a good antenna characterization, CNES and IGN jointly worked to establish a first error budget of the ground antenna position. With this aim in view, each component was clearly identified and studied separately. We distinguished between errors from manufacturing and from site surveying and, on the other hand, errors affecting horizontal and vertical position. The knowledge of the antenna geometry and the guarantee of a good reproducibility in the manufacturing process are essential. Based on these requirements, we have defined new manufacturing specifications to create a new antenna type: Starec type C. Compared to the previous antenna (Starec type B), the standard uncertainty of the 2 GHz phase center position in the vertical direction has been reduced from 5 mm to 1 mm. Following this work, we provide for the new Starec antenna (type C) total uncertainties involved in the ground antenna positioning in a local reference frame: 2 mm in the horizontal plane, 2.5 mm for the vertical component and 3.2 mm in three-dimensional combination. We also propose for DORIS new definitions of conventional points and a new method to determine ground antennas position that were not possible before this manufacturing specifications change.

  10. [Phylogeny of genus Spermophilus and position of Alashan ground squirrel (Spermophilus alashanicus, Buchner, 1888) on phylogenetic tree of Paleartic short-tailed ground squirrels].

    Science.gov (United States)

    Kapustina, S Yu; Brandler, O V; Adiya, Ya

    2015-01-01

    Phylogenetic relationships within a group of Paleartic short tailed ground squirrels (Spermophilus), recently defined as genus, are not sufficiently clear and need a critical revision. Interspecies hybridization, found in Eurasian Spermophilus, can affect the results of reconstruction of molecular phylogeny. Alashan ground squirrel position on the phylogenetic tree needs clarification. We analyzed eight nucleotide sequences of cytb gene of S. alashanicus and 127 sequences of other Spermophilus species form GenBank. S.alashanicus and S. dauricus close phylogenetic relationship, and their affinity to ancestral forms of the group are revealed. Monophyly of Colobotis subgenus was confirmed. Paraphyly of eastern and western forms of S. relictus was shown.

  11. Method of Calculation of Current of the Ground Faults in the Parallel Overhead Transmission Lines 110-220 Kv

    Directory of Open Access Journals (Sweden)

    Ukraintsev Alexandr V.

    2017-01-01

    Full Text Available The mutual induction between the phase wires of the different overhead lines which situate close to each other cause unbalanced redistribution of currents in the line wires. This leads to emergence of the outof-balance zero sequence current which affects negatively on the sensitivity of the zero-sequence current protection. It is impossible to estimate such out-ofbalance current by the means of the typical calculation programs for short circuit currents. This paper describes the method of “virtual” lines for an extra correction of the values of zero-sequence currents during the current ground faults happening in the overhead lines 110-220 kV. There is an example of using this method for three parallel overhead lines 220 kV passing close to each other.

  12. A logarithmic processor for Beam Position Measurements applied to a Transfer Line at CERN

    CERN Document Server

    Schmickler, Hermann

    2001-01-01

    The transfer line from the CERN proton synchrotron (PS) to the super proton synchrotron (SPS) requires a new beam position measurement system in view of the LHC. In this line, the single passage of various beam types (up to 7), induces signals with a global signal dynamics of more than 100 dB and with a wide frequency spectral distribution. Logarithmic amplifiers, have been chosen as technical solution for the challenges described above. The paper describes the details of the adopted solutions to make beam position measurements, with a resolution down to few 10-4 of the full pickup aperture over more than 50 dB of the total signal dynamics. The reported performances has been measured on the series production cards, already installed into the machine and on one pickup in the transfer line.

  13. Positive Solutions for Nonlinear Singular Differential Systems Involving Parameter on the Half-Line

    Directory of Open Access Journals (Sweden)

    Lishan Liu

    2012-01-01

    Full Text Available By using the upper-lower solutions method and the fixed-point theorem on cone in a special space, we study the singular boundary value problem for systems of nonlinear second-order differential equations involving two parameters on the half-line. Some results for the existence, nonexistence and multiplicity of positive solutions for the problem are obtained.

  14. PileLine: a toolbox to handle genome position information in next-generation sequencing studies

    Directory of Open Access Journals (Sweden)

    Fdez-Riverola Florentino

    2011-01-01

    Full Text Available Abstract Background Genomic position (GP files currently used in next-generation sequencing (NGS studies are always difficult to manipulate due to their huge size and the lack of appropriate tools to properly manage them. The structure of these flat files is based on representing one line per position that has been covered by at least one aligned read, imposing significant restrictions from a computational performance perspective. Results PileLine implements a flexible command-line toolkit providing specific support to the management, filtering, comparison and annotation of GP files produced by NGS experiments. PileLine tools are coded in Java and run on both UNIX (Linux, Mac OS and Windows platforms. The set of tools comprising PileLine are designed to be memory efficient by performing fast seek on-disk operations over sorted GP files. Conclusions Our novel toolbox has been extensively tested taking into consideration performance issues. It is publicly available at http://sourceforge.net/projects/pilelinetools under the GNU LGPL license. Full documentation including common use cases and guided analysis workflows is available at http://sing.ei.uvigo.es/pileline.

  15. Impact of SSSC on Measured Impedance in Single Phase to Ground Fault Condition on 220 kV Transmission Line

    Directory of Open Access Journals (Sweden)

    Mohamed ZELLAGUI

    2012-08-01

    Full Text Available This paper presents and compares the impact of SSSC on measured impedance for single phase to ground fault condition. The presence of Static Synchronous SSSC on a transmission line has a great influence on the ZRelay in distance protection. The protection of the high voltage 220 kV single circuit transmission line in eastern Algerian electrical transmission networks is affected in the case with resistance fault RF. The paper investigate the effect of Static Synchronous Series Compensator (SSSC on the measured impedance (Relay taking into account the distance fault point (n and fault resistance (RF. The resultants simulation is performed in MATLAB software environment.

  16. Determination of object position, vortex shedding frequency and flow velocity using artificial lateral line canals

    Directory of Open Access Journals (Sweden)

    Adrian Klein

    2011-06-01

    Full Text Available The lateral line system of fish consists of superficial neuromasts, and neuromasts embedded in lateral line canals. Lateral line neuromasts allow fish to sense both minute water motions and pressure gradients, thereby enabling them to detect predators and prey or to recognize and discriminate stationary objects while passing them. With the aid of the lateral line, fish can also sense vortices caused by an upstream object or by undulatory swimming movements of fish. We show here that artificial lateral line canals equipped with optical flow sensors can be used to detect the water motions generated by a stationary vibrating sphere, the vortices caused by an upstream cylinder or the water (air movements caused by a passing object. The hydrodynamic information retrieved from optical flow sensors can be used to calculate bulk flow velocity and thus the size of the cylinder that shed the vortices. Even a bilateral sensor platform equipped with only one artificial lateral line canal on each side is sufficient to determine the position of an upstream cylinder.

  17. Ground Water Redox Zonation near La Pine, Oregon: Relation to River Position within the Aquifer-Riparian Zone Continuum

    Science.gov (United States)

    Hinkle, Stephen R.; Morgan, David S.; Orzol, Leonard L.; Polette, Danial J.

    2007-01-01

    peripheral zones, whereas older, typically more reduced ground water tends to discharge closer to the center of the river corridor. Such distributions of redox state reflect ground-water movement and geochemical evolution at the aquifer-scale. Redox state of ground water undergoes additional modification as ground water nears discharge points in or adjacent to rivers, where riparian zone processes can be important. Lateral erosion of river systems away from the center of the flood plain can decrease or even eliminate interactions between ground water and reducing riparian zone sediments. Thus, ground water redox patterns in near-river sediments appear to reflect the position of a river within the riparian zone/aquifer continuum. Spatial heterogeneity of redox conditions near the river/aquifer boundary (that is, near the riverbed) makes it difficult to extrapolate transect-scale findings to a precise delineation of the oxic-suboxic boundary in the near-river environment of the entire study area. However, the understanding of relations between near-river redox state and proximity to riparian zone edges provides a basis for applying these results to the study-area scale, and could help guide management efforts such as nitrogen-reduction actions or establishment of Total Maximum Daily Load criteria. Coupling the ground-water redox-based understanding of river vulnerability with ground-water particle-tracking-based characterization of connections between upgradient recharge areas and receiving rivers demonstrates one means of linking effects of potential nitrate loads at the beginning of ground-water flow paths with river vulnerability.

  18. Ground Water Redox Zonation near La Pine, Oregon: Relation to River Position within the Aquifer-Riparian Zone Continuum

    Science.gov (United States)

    Hinkle, Stephen R.; Morgan, David S.; Orzol, Leonard L.; Polette, Danial J.

    2007-01-01

    peripheral zones, whereas older, typically more reduced ground water tends to discharge closer to the center of the river corridor. Such distributions of redox state reflect ground-water movement and geochemical evolution at the aquifer-scale. Redox state of ground water undergoes additional modification as ground water nears discharge points in or adjacent to rivers, where riparian zone processes can be important. Lateral erosion of river systems away from the center of the flood plain can decrease or even eliminate interactions between ground water and reducing riparian zone sediments. Thus, ground water redox patterns in near-river sediments appear to reflect the position of a river within the riparian zone/aquifer continuum. Spatial heterogeneity of redox conditions near the river/aquifer boundary (that is, near the riverbed) makes it difficult to extrapolate transect-scale findings to a precise delineation of the oxic-suboxic boundary in the near-river environment of the entire study area. However, the understanding of relations between near-river redox state and proximity to riparian zone edges provides a basis for applying these results to the study-area scale, and could help guide management efforts such as nitrogen-reduction actions or establishment of Total Maximum Daily Load criteria. Coupling the ground-water redox-based understanding of river vulnerability with ground-water particle-tracking-based characterization of connections between upgradient recharge areas and receiving rivers demonstrates one means of linking effects of potential nitrate loads at the beginning of ground-water flow paths with river vulnerability.

  19. Early outcome of second line antiretroviral therapy in treatment-experienced human immunodeficiency virus positive patients

    Directory of Open Access Journals (Sweden)

    Dishank Patel

    2013-01-01

    Full Text Available Purpose and Aim: Multi-drug resistance in treatment-experienced human immune deficiency virus (HIV patients has been a major cause to first line antiretroviral therapy (ART failure, necessitating a switch to second line therapy. In India, the second line treatment program is still relatively new with little experience and unclear outcomes. It is therefore, critical to assess the clinical, virological and immunological effectiveness and treatment outcome over the 1 st year of follow-up in the patients′ switched to the second line ART at public sector tertiary care center. Materials and Methods: A prospective, observational study was carried out on HIV positive patients switched on second line ART from January 2010 to December 2010 at ART Centre, Civil Hospital, Ahmedabad. Demographic details, symptoms, adverse drug reactions (ADRs, second line ART regimens, CD4 count, and plasma viral load (PVL were recorded in a case record form. Patients were followed-up monthly for 12 months. The data was analyzed by t-test, z-test, and Fisher-exact test. Results: Out of 126 patients, 82 received regimen V [zidovudine (ZDV + lamivudine (3TC + tenofovir (TDF + boosted lopinavir (LPV/r] and 44 received regimen Va [3TC + TDF + LPV/r]. A significant ( P < 0.0001 increase in mean body weight and marked reduction in number of patients (7 categorized as WHO stage III/IV was observed at 12 months of second line ART. Moreover, a significant immune reconstitution with increase in mean CD4 count and viral suppression (PVL < 400 copies/ml in 103 (82% patients ( P < 0.0001 was also observed. A total of 83 ADRs were observed in 69 (55% patients, the most common being dyslipidemia (57 followed by anemia (9. Conclusion: Early treatment outcome with second line ART was good with 82% success rate in treatment experienced HIV patients. Dyslipidemia and anemia were the common ADRs observed.

  20. LINES

    Directory of Open Access Journals (Sweden)

    Minas Bakalchev

    2015-10-01

    Full Text Available The perception of elements in a system often creates their interdependence, interconditionality, and suppression. The lines from a basic geometrical element have become the model of a reductive world based on isolation according to certain criteria such as function, structure, and social organization. Their traces are experienced in the contemporary world as fragments or ruins of a system of domination of an assumed hierarchical unity. How can one release oneself from such dependence or determinism? How can the lines become less “systematic” and forms more autonomous, and less reductive? How is a form released from modernistic determinism on the new controversial ground? How can these elements or forms of representation become forms of action in the present complex world? In this paper, the meaning of lines through the ideas of Le Corbusier, Leonidov, Picasso, and Hitchcock is presented. Spatial research was made through a series of examples arising from the projects of the architectural studio “Residential Transformations”, which was a backbone for mapping the possibilities ranging from playfulness to exactness, as tactics of transformation in the different contexts of the contemporary world.

  1. Transition and verification of ground fault protection method in Hokuriku Shinkansen line

    Directory of Open Access Journals (Sweden)

    Michiteru Koyanagi

    2016-01-01

    Full Text Available The electrical discharge gaps called S type horn are applied to the ground fault detection and protection in AC traction power supply system for high speed railway called Shinkansen. In this method, the earth resistance of the steel pipe pillar is an important factor for the ground fault protection by the electrical discharge. In this study, the analyses of the transient characteristics of grounding fault are carried out by using EMTP, and the ground resistance value required to trigger discharge at S type horn was calculated. Moreover, the protection effect of a discharge gap called GP the substation equipment that is a discharge gap which is inserted between rails and substation mesh is evaluated.

  2. Boundary condition of grounding lines prior to collapse, Larsen-B Ice Shelf, Antarctica.

    Science.gov (United States)

    Rebesco, M; Domack, E; Zgur, F; Lavoie, C; Leventer, A; Brachfeld, S; Willmott, V; Halverson, G; Truffer, M; Scambos, T; Smith, J; Pettit, E

    2014-09-12

    Grounding zones, where ice sheets transition between resting on bedrock to full floatation, help regulate ice flow. Exposure of the sea floor by the 2002 Larsen-B Ice Shelf collapse allowed detailed morphologic mapping and sampling of the embayment sea floor. Marine geophysical data collected in 2006 reveal a large, arcuate, complex grounding zone sediment system at the front of Crane Fjord. Radiocarbon-constrained chronologies from marine sediment cores indicate loss of ice contact with the bed at this site about 12,000 years ago. Previous studies and morphologic mapping of the fjord suggest that the Crane Glacier grounding zone was well within the fjord before 2002 and did not retreat further until after the ice shelf collapse. This implies that the 2002 Larsen-B Ice Shelf collapse likely was a response to surface warming rather than to grounding zone instability, strengthening the idea that surface processes controlled the disintegration of the Larsen Ice Shelf.

  3. Boundary condition of grounding lines prior to collapse, Larsen-B Ice Shelf, Antarctica

    OpenAIRE

    Rebesco, M.; Domack, E.; Zgur, F.; Lavoie, C.; Leventer, A.; Brachfeld, S.; Willmott, V.; Halverson, G.; M. Truffer; Scambos, T; Smith, J.; E. Pettit

    2014-01-01

    Grounding zones, where ice sheets transition between resting on bedrock to full floatation, help regulate ice flow. Exposure of the sea floor by the 2002 Larsen-B Ice Shelf collapse allowed detailed morphologic mapping and sampling of the embayment sea floor. Marine geophysical data collected in 2006 reveal a large, arcuate, complex grounding zone sediment system at the front of Crane Fjord. Radiocarbon-constrained chronologies from marine sediment cores indicate loss of ice contact with the ...

  4. Stepped Fault Line Selection Method Based on Spectral Kurtosis and Relative Energy Entropy of Small Current to Ground System

    Directory of Open Access Journals (Sweden)

    Xiaowei Wang

    2014-01-01

    Full Text Available This paper proposes a stepped selection method based on spectral kurtosis relative energy entropy. Firstly, the length and type of window function are set; then when fault occurs, enter step 1: the polarity of first half-wave extremes is analyzed; if the ratios of extremes between neighboring lines are positive, the bus bar is the fault line, else, the SK relative energy entropies are calculated, and then enter step 2: if the obtained entropy multiple is bigger than the threshold or equal to the threshold, the overhead line of max entropy corresponding is the fault line, if not, enter step 3: the line of max entropy corresponding is the fault line. At last, the applicability of the proposed algorithm is presented, and the comparison results are discussed.

  5. Reference Sphere Positioning Measurement Based on Line-Structured Light Vision Sensor

    Directory of Open Access Journals (Sweden)

    Bin Wu

    2013-01-01

    Full Text Available The line-structured light vision sensor has been used widely in industrial vision measuring fields due to its simple structure, small volume, light weight, low cost, convenient calibration, and high accuracy of measurement. To locate the reference sphere precisely with line-structured light vision sensor, a mathematical model based on the measuring principle of line-structured light vision sensor is established in the paper. Then, the positioning measurement error is analyzed in detail. The experimental results show that the method is valid and correct. In addition, an accurate measurement area which is from R0 × sin 45° to R0 × sin 75° away from the center of reference sphere is delimited through the statistical analysis of the experimental data. For the robot temperature compensation and calibration of flexible vision measurement system, this method effectively solves the positioning measurement problems about reference sphere with line-structured light vision sensor and has been applied in the industrial flexible online measurement systems successfully.

  6. POSITIONAL ERROR CURVES BAND OF A PLANAR LINE SEGMENT WITHIN GISs

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In this paper, the positional error curve of point features was extended to an error curves band of line segment features. Firstly, the constitution and shape of the error curves band were analyzed. On this basis, the general boundary curve formula of that band was derived. Secondly, the visualizing error curves bands were realized through three exam ples. Finally, area index has been examined by comparing numerical results from error curves band and error ellipes band.

  7. The positive side of a negative reference: the delay between linguistic processing and common ground

    Science.gov (United States)

    Noveck, Ira; Rivera, Natalia; Jaume-Guazzini, Francisco

    2017-01-01

    Interlocutors converge on names to refer to entities. For example, a speaker might refer to a novel looking object as the jellyfish and, once identified, the listener will too. The hypothesized mechanism behind such referential precedents is a subject of debate. The common ground view claims that listeners register the object as well as the identity of the speaker who coined the label. The linguistic view claims that, once established, precedents are treated by listeners like any other linguistic unit, i.e. without needing to keep track of the speaker. To test predictions from each account, we used visual-world eyetracking, which allows observations in real time, during a standard referential communication task. Participants had to select objects based on instructions from two speakers. In the critical condition, listeners sought an object with a negative reference such as not the jellyfish. We aimed to determine the extent to which listeners rely on the linguistic input, common ground or both. We found that initial interpretations were based on linguistic processing only and that common ground considerations do emerge but only after 1000 ms. Our findings support the idea that—at least temporally—linguistic processing can be isolated from common ground.

  8. Positive and ground state solutions for the critical Klein-Gordon-Maxwell system with potentials

    CERN Document Server

    Carriao, Paulo C; Miyagaki, Olimpio H

    2010-01-01

    In this paper we study a class of Klein-Gordon-Maxwell system when the nonlinearity exhibits critical growth. First we prove both existence and ground state solutions for this system with a periodic potencial V, and then we show the existence in the case that a nonperiodic potencial V is introduced.

  9. Study on deformation measurement of position and attitude based on the fold line videometrics

    Science.gov (United States)

    Tan, Xiao-lin; Jiang, Guang-wen; Fu, Sihua; Zhao, Chao

    2017-02-01

    Combining with the fold line videometrics, a method for pose estimation based on monocular measurements is studied. The method to measure the inertial position of the Photometric transfer station and the Orthogonal Iterative Algorithm based on the image space collinearity error is summarized. Then, the mistake using the Singular Value Decomposition (SVD) to solve is described and then introduce the improving algorithm. Finally, the Simulation and actual experiment is done to verify the accuracy of pose estimation using the fold line videometrics. The results show that the precision can reach 1mm or less using a camera with the resolution of 1280 by 1024 pixels, in the condition of 4.5 meter capturing distance and a Leica TS30.

  10. Mechanical stimulation of the foot sole in a supine position for ground reaction force simulation

    OpenAIRE

    2014-01-01

    Background:\\ud To promote early rehabilitation of walking, gait training can start even when patients are on bed rest. Supine stepping in the early phase after injury is proposed to maximise the beneficial effects of gait restoration. In this training paradigm, mechanical loading on the sole of the foot is required to mimic the ground reaction forces that occur during overground walking. A pneumatic shoe platform was developed to produce adjustable forces on the heel and the forefoot with an ...

  11. Extremum Seeking X-ray Position Feedback Using Power Line Harmonic Leakage as the Perturbation

    Energy Technology Data Exchange (ETDEWEB)

    Zohar, S.; Kissick, D. J.; Venugopalan, N.; Ogata, C. M.; Makarov, O.; Stepanov, S.; Fischetti, R. F.

    2016-09-12

    Small X-ray beam sizes necessary for probing nanoscale phenomena require exquisite stability to prevent data corruption by noise. One source of instability at synchrotron radiation X-ray beamlines is the slow detuning of X-ray optics to marginal alignment where the onset of clipping increases the beam’s susceptibility to higher frequency position oscillations. In this article, we show that a 1 µm amplitude horizontal X-ray beam oscillation driven by power line harmonic leakage into the electron storage ring can be used as perturbation for horizontal position extremum seeking feedback. Feedback performance is characterized by convergence to 1.5% away from maximum intensity at optimal alignment.

  12. Extremum Seeking X-Ray Position Feedback Using Power Line Harmonic Leakage as the Perturbation

    Energy Technology Data Exchange (ETDEWEB)

    Zohar, S.; Kissick, D. J.; Makarov, O.; Ogata, C. M.; Stepanov, S.; Fischetti, R. F.

    2016-09-12

    Small x-ray beam sizes necessary for probing nanoscale phenomena require exquisite stability to prevent data corruption by noise. One source of instability at synchrotron radiation x-ray beamlines is the slow detuning of x-ray optics to marginal alignment where the onset of clipping increases the beam's susceptibility to higher frequency position oscillations. In this article, we show that a 1 mu m amplitude horizontal x-ray beam oscillation driven by power line harmonic leakage into the electron storage ring can be used as perturbation for horizontal position extremum seeking feedback. Feedback performance is characterized by convergence to 1.5% away from maximum intensity at optimal alignment.

  13. Extremum seeking x-ray position feedback using power line harmonic leakage as the perturbation

    Directory of Open Access Journals (Sweden)

    S. Zohar

    2016-09-01

    Full Text Available Small x-ray beam sizes necessary for probing nanoscale phenomena require exquisite stability to prevent data corruption by noise. One source of instability at synchrotron radiation x-ray beamlines is the slow detuning of x-ray optics to marginal alignment where the onset of clipping increases the beam’s susceptibility to higher frequency position oscillations. In this article, we show that a 1  μm amplitude horizontal x-ray beam oscillation driven by power line harmonic leakage into the electron storage ring can be used as perturbation for horizontal position extremum seeking feedback. Feedback performance is characterized by convergence to 1.5% away from maximum intensity at optimal alignment.

  14. Position control of fishing line artificial muscles (coiled polymer actuators) from nylon thread

    Science.gov (United States)

    Arakawa, Takeshi; Takagi, Kentaro; Tahara, Kenji; Asaka, Kinji

    2016-04-01

    Recently, fishing line artificial muscle has been developed and is paid much attention due to the properties such as large contraction, light weight and extremely low cost. Typical fishing line artificial muscle is made from Nylon thread and made by just twisting the polymer. In this paper, because of the structure of the actuator, such actuators may be named as coiled polymer actuators (CPAs). In this paper, a CPA is fabricated from commercial Nylon fishing line and Ni-Cr alloy (Nichrome) wire is wound around it. The CPA contracts by the Joule heat generated by applied voltage to the Nichrome wire. For designing the control system, a simple model is proposed. According to the physical principle of the actuator, two first-order transfer functions are introduced to represent the actuator model. One is a system from the input power to the temperature and the other is a system from the temperature to the deformation. From the system identification result, it is shown that the dominant dynamics is the system from the input power to the temperature. Using the developed model, position control of the voltage-driven CPA is discussed. Firstly, the static nonlinearity from the voltage to the power is eliminated. Then, a 2-DOF PID controller which includes an inversion-based feed forward controller and a PID controller are designed. In order to demonstrate the proposed controller, experimental verification is shown.

  15. The Beam Position System of the CERN Neutrino to Gran Sasso Proton Beam Line

    CERN Document Server

    Bogey, T

    2008-01-01

    The CERN Neutrino to Gran Sasso (CNGS) experiment uses 400GeV protons extracted from the SPS, which travel along 825 meters of beam line before reaching the CNGS target. This beam line is equipped with 23 BPMs capable of measuring both the horizontal and vertical position of the beam. The final BPM is linked to the target station and due to radiation constraints has been designed to work in air. This contribution will give an overview of the BPMs used in the transfer line. It will also provide a detailed explanation of their logarithmic amplifier based acquisition electronics, which consists of an autotriggered sequencer controlling an integrator, the A/D conversion and the Manchester encoded transmission of the digital data to the surface. At the surface the digital data is acquired using the Digital Acquisition Board (DAB) developed by TRIUMF (Canada) for the LHC BPM system. Results from both laboratory measurements and beam measurements during the 2006 CNGS run will also be presented.

  16. Characterization of Line Nanopatterns on Positive Photoresist Produced by Scanning Near-Field Optical Microscope

    Directory of Open Access Journals (Sweden)

    Sadegh Mehdi Aghaei

    2015-01-01

    Full Text Available Line nanopatterns are produced on the positive photoresist by scanning near-field optical microscope (SNOM. A laser diode with a wavelength of 450 nm and a power of 250 mW as the light source and an aluminum coated nanoprobe with a 70 nm aperture at the tip apex have been employed. A neutral density filter has been used to control the exposure power of the photoresist. It is found that the changes induced by light in the photoresist can be detected by in situ shear force microscopy (ShFM, before the development of the photoresist. Scanning electron microscope (SEM images of the developed photoresist have been used to optimize the scanning speed and the power required for exposure, in order to minimize the final line width. It is shown that nanometric lines with a minimum width of 33 nm can be achieved with a scanning speed of 75 µm/s and a laser power of 113 mW. It is also revealed that the overexposure of the photoresist by continuous wave laser generated heat can be prevented by means of proper photoresist selection. In addition, the effects of multiple exposures of nanopatterns on their width and depth are investigated.

  17. Surface and line-edge roughness in acid-breakable resin-based positive resist

    Science.gov (United States)

    Sakamizu, Toshio; Shiraishi, Hiroshi

    2003-06-01

    A positive chemical amplification resist based on acid-catalyzed fragmentation of acetal groups in its main-chain has been developed as a means for reducing line-edge roughness. The resist consists of an acid-generator, an acid-diffusion controller and an acid-breakable (AB) resin that is synthesized through a co-condensation reaction between polyphenol and aromatic multi-functional vinylether compound. The effects of the fractionation of AB resins on resin properties and line-edge roughness (LER) are evaluated. Although AB resins have wide molecular-weight distributions, the density of acetal groups in this AB resin is found to be almost constant except in the lower molecular-weight components. The resist with a fractionated resin from which such components removed provides the high resolution of 60-nm line-and-space (L/S) patterns with fairly low LER. AFM analysis shows the surface roughness (SR) for the resist with the fractionated resin is smaller than that for a resist using non-fractionated AB resin, and that the SR value is not altered throughout the range of exposure doses up to just below the beginning of dissolution. By using the fractionated AB resin, the AB resin-based resist (ABR) is capable of forming sub-100 nm L/S patterns with less than 5 nm of LER (3σ).

  18. Measuring galaxy [OII] emission line doublet with future ground-based wide-field spectroscopic surveys

    CERN Document Server

    Comparat, Johan; Bacon, Roland; Mostek, Nick J; Newman, Jeffrey A; Schlegel, David J; Yèche, Christophe

    2013-01-01

    The next generation of wide-field spectroscopic redshift surveys will map the large-scale galaxy distribution in the redshift range 0.7< z<2 to measure baryonic acoustic oscillations (BAO). The primary optical signature used in this redshift range comes from the [OII] emission line doublet, which provides a unique redshift identification that can minimize confusion with other single emission lines. To derive the required spectrograph resolution for these redshift surveys, we simulate observations of the [OII] (3727,3729) doublet for various instrument resolutions, and line velocities. We foresee two strategies about the choice of the resolution for future spectrographs for BAO surveys. For bright [OII] emitter surveys ([OII] flux ~30.10^{-17} erg /cm2/s like SDSS-IV/eBOSS), a resolution of R~3300 allows the separation of 90 percent of the doublets. The impact of the sky lines on the completeness in redshift is less than 6 percent. For faint [OII] emitter surveys ([OII] flux ~10.10^{-17} erg /cm2/s like ...

  19. A beam position monitor for the diagnostic line in MEBT2 of J-PARC linac

    Science.gov (United States)

    Miura, A.; Tamura, J.; Kawane, Y.

    2017-07-01

    In the linac of the Japan Proton Accelerator Research Complex (J-PARC), the neutral hydrogen (H0) beam from the negative hydrogen ion (H-) beam is one of key issues in mitigating beam losses. To diagnose H0 particles, we installed a set of beam-bump magnets to generate a chicane orbit of the H- beam. The beam position monitors (BPMs) in the beam line are used for orbit correction to maintain the beam displacement within 2.0 mm from the duct center. To measure the beam displacement under different drive currents of the beam-bump magnets, a new wide-range BPM was designed and manufactured to evaluate the horizontal beam position by using a correction function to compensate for non-linearity. We also employed the beam profile monitor (WSM: wire scanner monitor) to measure the H- beam profile, which helped us to compare the beam position measurements. In this paper, the design and the performance of the wide-range BPM are described. In addition, we present a comparison of the beam position measured by the BPM and the WSM.

  20. Grounding line retreat of Pope, Smith, and Kohler Glaciers, West Antarctica, measured with Sentinel-1a radar interferometry data

    Science.gov (United States)

    Scheuchl, B.; Mouginot, J.; Rignot, E.; Morlighem, M.; Khazendar, A.

    2016-08-01

    We employ Sentinel-1a C band satellite radar interferometry data in Terrain Observation with Progressive Scans mode to map the grounding line and ice velocity of Pope, Smith, and Kohler glaciers, in West Antarctica, for the years 2014-2016 and compare the results with those obtained using Earth Remote Sensing Satellites (ERS-1/2) in 1992, 1996, and 2011. We observe an ongoing, rapid grounding line retreat of Smith at 2 km/yr (40 km since 1996), an 11 km retreat of Pope (0.5 km/yr), and a 2 km readvance of Kohler since 2011. The variability in glacier retreat is consistent with the distribution of basal slopes, i.e., fast along retrograde beds and slow along prograde beds. We find that several pinning points holding Dotson and Crosson ice shelves disappeared since 1996 due to ice shelf thinning, which signal the ongoing weakening of these ice shelves. Overall, the results indicate that ice shelf and glacier retreat in this sector remain unabated.

  1. Spatiotemporal characteristics of positive cloud-to-ground lightning discharges and bidirectional leader of the lightning

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The three-dimension spatiotemporal development characteristics of positive cloud-toground (CG) lightning discharges have been analyzed by using the data measured by the lightning mapping array system with high time and space resolution. The results indicate that a positive CG lightning discharge can be divided into three stages based on the characteristics of its development. The first stage is discharge process in cloud with a long duration preceding the return stroke. This process with an average of 370 ms propagated at velocity of 105 m/s and produced intensive radiation with a magnitude equal to that of the negative leader. During this stage, the lightning channels developed horizontally in the positive charge region with few branches as the negative polarity breakdown. During the stage after the return stroke of the positive CG lightning, the lightning channels propagated at velocity of 2 times faster than that before the return stroke. This stage involved lots of positive fast impulses and corresponded to the continuing current process producing less and dispersed radiation points and more intensive radiation powers. During the final stage of the positive CG lightning, the lightning channels developed at velocity equal to that before the return stroke and the radiation points appeared mainly at the ends of channel. The spatiotemporal development characteristics of the positive CG lightning are very different from that of the negative CG lightning. All of the radiation points of the positive CG lightning appeared in the positive charge region of cloud. Little or no radiation was detected during the positive leader just before the return stroke. The duration of the positive CG lightning was an average of 730 ms. The positive CG lightning discharges with lasting time of 500-600 ms were 43%. 90% of the positive CG lightning discharges involved one return stroke, the most return stroke number being four. The current of the return stroke was an average of 36.5 k

  2. ROVIBRATIONAL LINE LISTS FOR NINE ISOTOPOLOGUES OF THE CO MOLECULE IN THE X {sup 1}Σ{sup +} GROUND ELECTRONIC STATE

    Energy Technology Data Exchange (ETDEWEB)

    Li, Gang; Gordon, Iouli E.; Rothman, Laurence S. [Harvard-Smithsonian Center for Astrophysics, Atomic and Molecular Physics Division, Cambridge, MA 02138 (United States); Tan, Yan; Hu, Shui-Ming [Hefei National Laboratory for Sciences at Microscale, University of Science and Technology of China, 230026 Hefei (China); Kassi, Samir; Campargue, Alain [Laboratoire Interdisciplinaire de Physique, CNRS UMR 5588, Université Joseph Fourier de Grenoble, B.P. 87, F-38402 Saint-Martin-d' Hères Cedex (France); Medvedev, Emile S., E-mail: igordon@cfa.harvard.edu [The Institute of Problems of Chemical Physics, Russian Academy of Science, Prospect Akademika Semenova 1, 142432 Chernogolovka (Russian Federation)

    2015-01-01

    Extensive rovibrational line lists were computed for nine isotopologues of the CO molecule, namely, {sup 12}C{sup 16}O, {sup 12}C{sup 17}O, {sup 12}C{sup 18}O, {sup 13}C{sup 16}O, {sup 13}C{sup 17}O, {sup 13}C{sup 18}O, {sup 14}C{sup 16}O, {sup 14}C{sup 17}O, and {sup 14}C{sup 18}O in the ground electronic state with v ≤ 41, Δv ≤ 11, and J ≤ 150. The line intensity and position calculations were carried out using a newly determined piece-wise dipole moment function (DMF) in conjunction with the wavefunctions calculated from an experimentally determined potential energy function from Coxon and Hajigeorgiou. A direct-fit method that simultaneously fits all the reliable experimental rovibrational matrix elements has been used to construct the dipole moment function near equilibrium internuclear distance. In order to extend the amount and quality of input experimental parameters, new Cavity Ring Down Spectroscopy experiments were carried out to enable measurements of the lines in the 4-0 band with low uncertainty as well as the first measurements of lines in the 6-0 band. A new high-level ab initio DMF, derived from a finite field approach has been calculated to cover internuclear distances far from equilibrium. Accurate partition sums have been derived for temperatures up to 9000 K. In addition to air- and self-induced broadening and shift parameters, those induced by CO{sub 2} and H{sub 2} are now provided for planetary applications. A complete set of broadening and shift parameters was calculated based on sophisticated extrapolation of high-quality measured data. The line lists, which follow HITRAN formalism, are provided as supplementary material.

  3. Analysis of the grounding system for a mobile communication site placed on HV power line mast

    Science.gov (United States)

    Bîrsan, I.; Munteanu, C.; Horgoș, M.; Ilut, T.

    2016-08-01

    This paper aims to analyze the potential distribution on the soil surface or potential variation on the main directions inside computing mobile site. I want to study a system made the earth a mobile communications site, antennas operator and the system of which the earth is placed on a High Voltage Power Line Mast (LEA 110 KV). I made direct measurements and I use a 3D software for analyze the results and simulating some possible solutions.

  4. Relativistic positioning: errors due to uncertainties in the satellite world lines

    CERN Document Server

    Puchades, Neus

    2014-01-01

    Global navigation satellite systems use appropriate satellite constellations to get the coordinates of an user -close to Earth- in an almost inertial reference system. We have simulated both GPS and GALILEO constellations. Uncertainties in the satellite world lines lead to dominant positioning errors. In this paper, a detailed analysis of these errors is developed inside a great region surrounding Earth. This analysis is performed in the framework of the so-called relativistic positioning systems. Our study is based on the Jacobian, J, of the transformation giving the emission coordinates in terms of the inertial ones. Around points of vanishing J, positioning errors are too large. We show that, for any 4-tuple of satellites, the points with J=0 are located at distances, D, from the Earth centre greater than about 2R/3, where R is the radius of the satellite orbits which are assumed to be circumferences. Our results strongly suggest that, for D-distances greater than 2R/3 and smaller than 100000 km, a rather ...

  5. A positioning system with no line-of-sight restrictions for cluttered environments

    Science.gov (United States)

    Prigge, Eric A.

    Accurate sensing of vehicle location and attitude is a fundamental requirement in many mobile-robot applications, but is a very challenging problem in the cluttered and unstructured environment of the real world. Many existing indoor positioning systems are limited in workspace and robustness because they require clear lines of sight or do not provide absolute, drift-free measurements. Examples include overhead vision systems, where an unobstructed view must be maintained between robot and camera, and inertial systems, where the measurements drift over time. The research presented in this dissertation provides a new location- and attitude-sensing system designed specifically to meet the challenges of operation in a realistic, cluttered indoor environment, such as that of an office building or warehouse. The system is not limited by line-of-sight restrictions and produces drift-free measurements throughout a three-dimensional operating volume that can span a large building. Accuracy of several centimeters and a few degrees is delivered at 10 Hz, and any number of the small sensor units can be in operation, all providing estimates in a common reference frame. This positioning system is based on extremely-low-frequency magnetic fields, which have excellent characteristics for penetrating line-of-sight obstructions. Beacons located throughout the workspace create the low-level fields. A sensor unit on the mobile robot samples the local magnetic field and processes the measurements to determine its location and attitude. This research overcomes limitations in existing magnetic-based systems. The design of the signal structure, based on pseudorandom codes, enables the use of multiple, distributed L-beacons and greatly expands coverage volume. The development of real-time identification and correction methods mitigates the impact of distortions caused by materials in the environment. A novel solution algorithm combats both challenges, providing increased coverage volume

  6. First-line treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia in adults.

    Science.gov (United States)

    Ottmann, Oliver G; Pfeifer, Heike

    2009-06-01

    The tyrosine kinase inhibitor (TKI) imatinib has become an integral part of front-line therapy for Philadelphia chromosome-positive acute lymphoblastic leukaemia, with remission rates exceeding 90% irrespective of whether imatinib is given alone or combined with chemotherapy. Treatment outcome with imatinib-based regimens has improved compared with historic controls, but most patients who do not undergo allogeneic stem cell transplantation (SCT) eventually relapse. Second-generation TKI, e.g. dasatinib and nilotinib, show activity against most of the bcr-abl tyrosine kinase domain mutations involved in acquired imatinib resistance, but clinical benefit is generally short lived. Accordingly, SCT in first complete response is considered to be the best curative option. Strategies to improve outcome in patients ineligible for transplantation as well as after SCT include front-line treatment with more effective TKI to increase molecular response rates. Following SCT, the pre-emptive use of imatinib appears to reduce the relapse rate. Novel immunotherapeutic interventions and combinations of TKI are also being explored.

  7. Absolute Position Sensing Based on a Robust Differential Capacitive Sensor with a Grounded Shield Window.

    Science.gov (United States)

    Bai, Yang; Lu, Yunfeng; Hu, Pengcheng; Wang, Gang; Xu, Jinxin; Zeng, Tao; Li, Zhengkun; Zhang, Zhonghua; Tan, Jiubin

    2016-05-11

    A simple differential capacitive sensor is provided in this paper to measure the absolute positions of length measuring systems. By utilizing a shield window inside the differential capacitor, the measurement range and linearity range of the sensor can reach several millimeters. What is more interesting is that this differential capacitive sensor is only sensitive to one translational degree of freedom (DOF) movement, and immune to the vibration along the other two translational DOFs. In the experiment, we used a novel circuit based on an AC capacitance bridge to directly measure the differential capacitance value. The experimental result shows that this differential capacitive sensor has a sensitivity of 2 × 10(-4) pF/μm with 0.08 μm resolution. The measurement range of this differential capacitive sensor is 6 mm, and the linearity error are less than 0.01% over the whole absolute position measurement range.

  8. Effect of translational and rotational errors on complex dose distributions with off-line and on-line position verification

    NARCIS (Netherlands)

    I.M. Lips; U.A. van der Heide; A.N.T.J. Kotte; M. van Vulpen; A. Bel

    2009-01-01

    PURPOSE: To investigate the influence of translational and rotational errors on prostate intensity-modulated radiotherapy (IMRT) with an integrated boost to the tumor and to evaluate the effect of the use of an on-line correction protocol. METHODS AND MATERIALS: For 19 patients, who had been treated

  9. Cytoskeletal regulation dominates temperature-sensitive proteomic changes of hibernation in forebrain of 13-lined ground squirrels.

    Directory of Open Access Journals (Sweden)

    Allyson G Hindle

    Full Text Available 13-lined ground squirrels, Ictidomys tridecemlineatus, are obligate hibernators that transition annually between summer homeothermy and winter heterothermy - wherein they exploit episodic torpor bouts. Despite cerebral ischemia during torpor and rapid reperfusion during arousal, hibernator brains resist damage and the animals emerge neurologically intact each spring. We hypothesized that protein changes in the brain underlie winter neuroprotection. To identify candidate proteins, we applied a sensitive 2D gel electrophoresis method to quantify protein differences among forebrain extracts prepared from ground squirrels in two summer, four winter and fall transition states. Proteins that differed among groups were identified using LC-MS/MS. Only 84 protein spots varied significantly among the defined states of hibernation. Protein changes in the forebrain proteome fell largely into two reciprocal patterns with a strong body temperature dependence. The importance of body temperature was tested in animals from the fall; these fall animals use torpor sporadically with body temperatures mirroring ambient temperatures between 4 and 21°C as they navigate the transition between summer homeothermy and winter heterothermy. Unlike cold-torpid fall ground squirrels, warm-torpid individuals strongly resembled the homeotherms, indicating that the changes observed in torpid hibernators are defined by body temperature, not torpor per se. Metabolic enzymes were largely unchanged despite varied metabolic activity across annual and torpor-arousal cycles. Instead, the majority of the observed changes were cytoskeletal proteins and their regulators. While cytoskeletal structural proteins tended to differ seasonally, i.e., between summer homeothermy and winter heterothermy, their regulatory proteins were more strongly affected by body temperature. Changes in the abundance of various isoforms of the microtubule assembly and disassembly regulatory proteins

  10. Up-regulation of Long Non-coding RNA TUG1 in Hibernating Thirteen-lined Ground Squirrels

    Directory of Open Access Journals (Sweden)

    Jacques J. Frigault

    2016-04-01

    Full Text Available Mammalian hibernation is associated with multiple physiological, biochemical, and molecular changes that allow animals to endure colder temperatures. We hypothesize that long non-coding RNAs (lncRNAs, a group of non-coding transcripts with diverse functions, are differentially expressed during hibernation. In this study, expression levels of lncRNAs H19 and TUG1 were assessed via qRT-PCR in liver, heart, and skeletal muscle tissues of the hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus. TUG1 transcript levels were significantly elevated 1.94-fold in skeletal muscle of hibernating animals when compared with euthermic animals. Furthermore, transcript levels of HSF2 also increased 2.44-fold in the skeletal muscle in hibernating animals. HSF2 encodes a transcription factor that can be negatively regulated by TUG1 levels and that influences heat shock protein expression. Thus, these observations support the differential expression of the TUG1–HSF2 axis during hibernation. To our knowledge, this study provides the first evidence for differential expression of lncRNAs in torpid ground squirrels, adding lncRNAs as another group of transcripts modulated in this mammalian species during hibernation.

  11. Up-regulation of Long Non-coding RNA TUG1 in Hibernating Thirteen-lined Ground Squirrels

    Institute of Scientific and Technical Information of China (English)

    Jacques J. Frigault; Daneck Lang-Ouellette; Pier Morin Jr.

    2016-01-01

    Mammalian hibernation is associated with multiple physiological, biochemical, and molecular changes that allow animals to endure colder temperatures. We hypothesize that long non-coding RNAs (lncRNAs), a group of non-coding transcripts with diverse functions, are differ-entially expressed during hibernation. In this study, expression levels of lncRNAs H19 and TUG1 were assessed via qRT-PCR in liver, heart, and skeletal muscle tissues of the hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus). TUG1 transcript levels were signifi-cantly elevated 1.94-fold in skeletal muscle of hibernating animals when compared with euthermic animals. Furthermore, transcript levels of HSF2 also increased 2.44-fold in the skeletal muscle in hibernating animals. HSF2 encodes a transcription factor that can be negatively regulated by TUG1 levels and that influences heat shock protein expression. Thus, these observations support the differential expression of the TUG1–HSF2 axis during hibernation. To our knowledge, this study provides the first evidence for differential expression of lncRNAs in torpid ground squirrels, adding lncRNAs as another group of transcripts modulated in this mammalian species during hibernation.

  12. An ANN-Based Synthesis Model for Parallel Coupled Microstrip Lines with Floating Ground-Plane Conductor and Its Applications

    Directory of Open Access Journals (Sweden)

    Yuan Cao

    2016-01-01

    Full Text Available To directly obtain physical dimensions of parallel coupled microstrip lines with a floating ground-plane conductor (PCMLFGPC, an accurate synthesis model based on an artificial neural network (ANN is proposed. The synthesis model is validated by using the conformal mapping technique (CMT analysis contours. Using the synthesis model and the CMT analysis, the PCMLFGPC having equal even- and odd-mode phase velocities can be obtained by adjusting the width of the floating ground-plane conductor. Applying the method, a 7 dB coupler with the measured isolation better than 27 dB across a wide bandwidth (more than 120%, a 90° Schiffman phase shifter with phase deviation ±2.5° and return loss more than 17.5 dB covering 63.4% bandwidth, and a bandpass filter with completely eliminated second-order spurious band are implemented. The performances of the current designs are superior to those of the previous components configured with the PCMLFGPC.

  13. Retroperitoneal Lymph Node Dissection as First-Line Treatment of Node-Positive Seminoma.

    Science.gov (United States)

    Hu, Brian; Shah, Swar; Shojaei, Sepehr; Daneshmand, Siamak

    2015-08-01

    The long-term morbidity associated with treating advanced seminoma can be significant. Retroperitoneal lymph node dissection (RPLND) has established oncologic efficacy in treating germ cell tumors with minimal long-term toxicity. We describe our experience with RPLND as a front-line treatment of lymph node-positive seminoma. We reviewed our institutional review board-approved testicular cancer database to find the patients with pure seminoma and isolated retroperitoneal lymph node disease who had undergone primary RPLND. The clinical and pathologic variables were obtained. The follow-up data were used to determine recurrence and death. Four patients with a mean age of 37 years were identified. All patients had normal tumor markers and retroperitoneal lymphadenopathy measuring 1.1, 1.5, 1.8, and 5.5 cm before RPLND. Of the 4 patients, 3 had had seminoma diagnosed at orchiectomy and 1 (with a 5.5-cm retroperitoneal lymphadenopathy and a burned out primary testicular mass) had had seminoma diagnosed at RPLND after 2 nondiagnostic retroperitoneal biopsies. All patients had undergone nerve-sparing, template, extraperitoneal RPLND and were discharged home after 3 days. An average of 3 positive lymph nodes were found. Of the 4 patients, 3 had pathologic stage IIA and 1 stage IIB disease, with no patient undergoing adjuvant therapy. At a mean follow-up period of 25 months, no patient had experienced disease recurrence, and none had died. All patients maintained antegrade ejaculation, and no long-term complications had developed. Our small series has demonstrated encouraging oncologic efficacy for RPLND as a primary treatment of retroperitoneal lymph node-positive seminoma. A multi-institutional phase II trial of RPLND for stage IIA seminoma is being developed. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Determination of the Position of a Tectonic Dislocation in the Shape of a Line, which is Radiating Gamma Rays

    Directory of Open Access Journals (Sweden)

    Pavel Virdzek

    2005-01-01

    Full Text Available In the present paper we describe a computation of the position of a tectonic dislocation in the shape of a line, which is radiating gamma rays. We derive the equation for dose rate as a function of the distance of the point of measurement from the irradiation line. The theoretical calculation of the position of this line is shown for the case of zero radiation of the background as well as for the case when the radiation of the background is considered.

  15. The application of fuzzy theory for the control of weld line positions in injection-molded part.

    Science.gov (United States)

    Chen, Mei-Yung; Tzeng, Huan-Wen; Chen, Yi-Cheng; Chen, Shia-Chung

    2008-01-01

    This research proposes the fuzzy theory for the control of weld lines in plastic injection molding. The weld line occurs as a result of geometrical changes in molded parts in the injection molding process. The weld line is one of the defects present in plastic injection-molded parts; the line affects the quality of parts as well as the strength of the products. In the present study, fuzzy theory was applied in the design of injection molding. First, expert experiences were transformed into IF approximately THEN approximately rules to establish the knowledge base for developing fuzzy inference rules. The rules were then used to adjust the molding parameters, which in turn were applied to control the weld line position in the injection molding process. The results indicate that fuzzy theory exhibited favorable applicability in the control of the weld line as well as decreased the simulation time, thereby accelerating the design process of injection molding.

  16. Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer.

    Science.gov (United States)

    Keating, Gillian M

    2012-02-12

    The humanized monoclonal antibody pertuzumab is the first in a new class of drugs, the human epidermal growth factor receptor (HER) dimerization inhibitors. Given that pertuzumab binds to a different epitope of the HER2 extracellular domain than trastuzumab, combination therapy with pertuzumab plus trastuzumab may result in more comprehensive blockade of HER2 signalling than can be achieved with trastuzumab alone. The efficacy of adding pertuzumab to trastuzumab plus docetaxel for the first-line treatment of HER2-positive metastatic breast cancer was demonstrated in the randomized, double-blind, multinational, phase III CLEOPATRA trial. Both independently assessed progression-free survival (primary endpoint) and investigator-assessed progression-free survival were significantly improved in patients receiving pertuzumab plus trastuzumab and docetaxel compared with those receiving placebo plus trastuzumab and docetaxel. The prespecified interim analysis of survival revealed a strong trend towards a survival benefit associated with pertuzumab, although this was not considered statistically significant. The objective response rate was higher with pertuzumab than with placebo. Intravenous pertuzumab had an acceptable tolerability profile when added to trastuzumab and docetaxel in the CLEOPATRA trial.

  17. Brief Analysis on the Theory of Fault Line Selection of Single Phase Grounding in Small Current Neutral Grounding System%浅析小电流接地系统单相接地故障选线原理

    Institute of Scientific and Technical Information of China (English)

    邢威

    2015-01-01

    文章纵观小电流接地选线的发展历史,简要概括了小电流接地系统发生单相接故障时系统基本特征,分析了几种选线原理的特点,提出了尚需解决的问题,最后给出了分析结论。%In the view of the history of small current grounding fault line selection, the basic features of small current grounding system when single phase grounding failure occurs were briefly summarized, and several characteristics of fault line selection were analyzed, the problems need to be solved were proposed, and the analysis of ifndings was given.

  18. Detecting the single line to ground short circuit fault in the submarine’s power system using the artificial neural network

    Directory of Open Access Journals (Sweden)

    Behniafar Ali

    2013-01-01

    Full Text Available The electric marine instruments are newly inserted in the trade and industry, for which the existence of an equipped and reliable power system is necessitated. One of the features of such a power system is that it cannot have an earth system causing the protection relays not to be able to detect the single line to ground short circuit fault. While on the other hand, the occurrence of another similar fault at the same time can lead to the double line fault and thereby the tripping of relays and shortening of vital loads. This in turn endangers the personals' security and causes the loss of military plans. From the above considerations, it is inferred that detecting the single line to ground fault in the marine instruments is of a special importance. In this way, this paper intends to detect the single line to ground fault in the power systems of the marine instruments using the wavelet transform and Multi-Layer Perceptron (MLP neural network. In the numerical analysis, several different types of short circuit faults are simulated on several marine power systems and the proposed approach is applied to detect the single line to ground fault. The results are of a high quality and preciseness and perfectly demonstrate the effectiveness of the proposed approach.

  19. Dismantling the present and future threats of testicular cancer: a grounded theory of positive and negative adjustment trajectories.

    Science.gov (United States)

    Matheson, Lauren; Boulton, Mary; Lavender, Verna; Protheroe, Andrew; Brand, Sue; Wanat, Marta; Watson, Eila

    2016-02-01

    Testicular cancer commonly affects men in the prime of their lives. While survival rates are excellent, little previous research has examined men's experiences of adjustment to survivorship. We aimed to explore this issue in younger testicular cancer survivors. In-depth qualitative interviews were conducted with testicular cancer survivors over two time points approximately 6 months apart in the year following treatment completion. Interviews were analysed using a grounded theory approach. The sample included 18 testicular cancer survivors between 22 and 44 years (mean age 34). A grounded theory was developed, which explained the process of positive adjustment over the first year following the treatment completion in terms of men's ability to dismantle the present and future threats of cancer, involving the key transitions of gaining a sense of perspective and striving to get on with life and restore normality. These were facilitated by six key processes. The processes that explained a negative adjustment trajectory are also presented. These findings contribute to the understanding of the psychosocial impact of testicular cancer on younger men's lives and have implications for the provision of support to testicular cancer survivors. Further investigation into the feasibility of one-on-one peer support interventions is warranted, as well as informal support that respects men's desire for independence. Understanding the processes involved in adjustment highlights ways in which health professionals can offer support to those struggling to adjust through challenging illness beliefs, encouraging emotional disclosure and facilitating peer mentoring.

  20. Combining Interferometer, LMA, and ΔE measurements on positive cloud-to-ground flashes over Langmuir Laboratory

    Science.gov (United States)

    Sonnenfeld, R. G.; Lapierre, J. L.; Edens, H. E.; Jensen, D.; Stock, M.; Zhang, Y.

    2015-12-01

    Positive cloud-to-ground (+CG) lightning flashes are considerably lesscommon than -CG flashes, and the +CG/-CG ratio has a geographicaldependence. +CG flashes are much more common in supercell storms in Oklahomaand Colorado, for example, than in the small convective cellscharacteristic of New Mexico mountain storms.Since +CG flashes in New Mexico are relatively rare, they have been muchless studied here. In this study, we combined a digital interferometer(INTF) operating in the 20--80~MHz band with cost-reduced flat plateantennae (based on the recently published design by Stock, et al.) witha lightning mapping array. The INTF provides only 2-dimensional maps oflightning, but can be interpolated to 3-D with the integration of lightningmapping array (LMA) data. Finally, we combined ΔE-field(slow-antenna) sensors to characterize the gross charge motion of theflashes (and pre-select positive CG candidates).By combining these data sets, we expect to learn more about therelationship between continuing current and M-components during CG flashesand the in-cloud activity associated with these phenomena. Early resultsseem to indicate that positive CG's with continuing currents reveal channelgrowth in the clouds associated with the production of continuing current.This stands in contrast to prior findings on negative CG's which showed nocorrelation between in-cloud channel development and the presence orabsence of continuing current.

  1. Positive Charge Region in Lower Part of Thunderstorm and Preliminary Breakdown Process of Negative Cloud-to-Ground Lightning

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yijun; MENG Qing; LU Weitao; MA Ming; ZHENG Dong; Pau R. Krehbiel

    2009-01-01

    A new lightning locating technology, called Lightning Mapping Array (LMA), has been developed. The system takes advantage of GPS technology to measure the times of arrival (TOA) of lightning impulsive very high frequency (VHF) radiation events at each remote location. The spatiotemporal development processes of lightning are described in three-dimension by measurement of the system with high time resolution (50 ns) and space precision (50-100 m). The charge structures in thunderstorm and their relationship with lightning discharge processes are revealed. The temporal and spatial characteristics of preliminary breakdown process involved in negative cloud-to-ground (CG) lightning discharges are analyzed based on the data of lightning VHF radiation events. The effect of positive charge region in lower part of thunderstorm on the occurrence of negative CG lightning discharge is discussed. The results indicate that the preliminary breakdown process with longer duration in negative CG lightning discharges is an intracloud discharge process. It occurs between negative and positive charge regions located in middle and lower parts of thunderstorm respectively.It initiates from the negative charge region and propagates downward. After propagating into the positive charge region, the lightning channel develops horizontally. The characteristics of the preliminary breakdown process are consistent with that of intracloud lightning discharges. The stepped leaders are initiated by the K type breakdown which occurs in the last stage of the preliminary breakdown process and develops downward through the positive charge region. The existence of positive charge region in lower part of thunderstorm results in the occurrence of preliminary breakdown process with longer duration before the return stroke of negative CG lightning discharges.

  2. Ground-penetrating radar and differential global positioning system data collected from Long Beach Island, New Jersey, April 2015

    Science.gov (United States)

    Zaremba, Nicholas J.; Smith, Kathryn E.L.; Bishop, James M.; Smith, Christopher G.

    2016-08-04

    Scientists from the United States Geological Survey, St. Petersburg Coastal and Marine Science Center, U.S. Geological Survey Pacific Coastal and Marine Science Center, and students from the University of Hawaii at Manoa collected sediment cores, sediment surface grab samples, ground-penetrating radar (GPR) and Differential Global Positioning System (DGPS) data from within the Edwin B. Forsythe National Wildlife Refuge–Holgate Unit located on the southern end of Long Beach Island, New Jersey, in April 2015 (FAN 2015-611-FA). The study’s objective was to identify washover deposits in the stratigraphic record to aid in understanding barrier island evolution. This report is an archive of GPR and DGPS data collected from Long Beach Island in 2015. Data products, including raw GPR and processed DGPS data, elevation corrected GPR profiles, and accompanying Federal Geographic Data Committee metadata can be downloaded from the Data Downloads page.

  3. PileLineGUI: a desktop environment for handling genome position files in next-generation sequencing studies.

    Science.gov (United States)

    López-Fernández, Hugo; Glez-Peña, Daniel; Reboiro-Jato, Miguel; Gómez-López, Gonzalo; Pisano, David G; Fdez-Riverola, Florentino

    2011-07-01

    Next-generation sequencing (NGS) technologies are making sequence data available on an unprecedented scale. In this context, new catalogs of Single Nucleotide Polymorphism and mutations generated by resequencing studies are usually stored in genome position files (e.g. Variant Call Format, SAMTools pileup, BED, GFF) comprising of large lists of genomic positions, which are difficult to handle by researchers. Here, we present PileLineGUI, a novel desktop application primarily designed for manipulating, browsing and analysing genome position files (GPF), with specific support to somatic mutation finding studies. The developed tool also integrates a new genome browser module specially designed for inspecting GPFs. PileLineGUI is free, multiplatform and designed to be intuitively used by biomedical researchers. PileLineGUI is available at: http://sing.ei.uvigo.es/pileline/pilelinegui.html.

  4. Cover Lines Using Positive, Urgent, Unique Language Entice Moms to Read Health Communications.

    Science.gov (United States)

    Martin-Biggers, Jennifer; Beluska, Katrina; Quick, Virginia; Tursi, Mary; Byrd-Bredbenner, Carol

    2015-01-01

    Crafting messages that capture consumer interest is a frequent challenge of health communicators. A better understanding of the techniques magazine editors use to create cover lines may aid health communicators in their efforts to arouse interest in their communiqués. This study (a) content-analyzed magazine cover lines, (b) used content analysis findings to create health-related cover lines, and (c) assessed the degree to which the health-related cover lines fostered motivation to read the health communication. Cover lines (N = 867) from 11 magazines published in 2012 frequently read by mothers of young children used a variety of themes, with those focusing on informative/how-to, control/improve, and unique/special being most common. Health communication experts used key descriptor terms corresponding to each theme and wrote 310 cover lines for topics focusing on childhood obesity prevention strategies. Unpaired t tests revealed that mothers of young children (N = 77) reported they were significantly (p health-related magazine article when cover lines had a happiness/fun, unique/special, or quick/urgency theme and were significantly less motivated to read when cover lines used a control/improve theme. Study findings may help health communicators create cover lines that better attract reader attention.

  5. Position Measurements with Micro-Channel Plates and Transmission lines using Pico-second Timing and Waveform Analysis

    CERN Document Server

    Adamsa, Bernhard; Bogdan, Mircea; Byrum, Karen; Genat, Jean-Francois C; Grabas, Herve; Frisch, Henry J; Kim, Heejong; Heintz, Mary K; Natoli, Tyler; Northrop, Richard; Oberla, Eric; Meehan, Samuel; May, Edward N; Stanek, Robert; Tang, Fukun; Varner, Gary; Yurtsev, Eugene

    2009-01-01

    The anodes of Micro-Channel Plate devices are coupled to fast transmission lines in order to reduce the number of electronics readout channels, and can provide two-dimension position measurements using two-ends delay timing. Tests with a laser and digital waveform analysis show that resolutions of a few hundreds of microns along the transmission line can be reached taking advantage of a few pico-second timing estimation. This technique is planned to be used in Micro-channel Plate devices integrating the transmission lines as anodes.

  6. FISHING GROUND, CACTH COMPOSITION, HOOK RATE AND LENGTH DISTRIBUTION OF BILLFISHES CAUGHT BY TUNA LONG LINE IN INDIAN OCEAN

    Directory of Open Access Journals (Sweden)

    Fathur Rochman

    2013-12-01

    Full Text Available Billfishes area by cacth of tuna long line vessels in Indian Ocean. Billfish are consist of swordfish Xiphias gladius, black marlin Makaira indica, indo facific blue marlin Makaira mazara, stripe marlin Tetrapturus audax, indo facific sailfish Istiophorus platypterus and shortbill spearfish Tetrapturus angustirostris. Besides that, billfishes also have important economic value compared with tuna as an exsported species such as swordfish and marlin. To optimize the catch of billfishes in Indian Ocean, data and information of potential fishing ground, size and catch composition of this species are needed. The billfishes cacth composition collected in 2011 were dominated by 45% swordfish, 20% black marlin, 19% blue marlin,9% short bill spearfish, 6% sailfish and 1%stripe marlin. The billfishes size range which were caught between 60 - 280 cm LJFL (Lower Jaw Fork Length. The sword fish average length was 150 cm, blue marlin 197 cm, black Marlin 189 cm, sailfish 150cm ,short bill spearfish 144 cm and stripe marlin159 cm. From this observation, it was found that most of billfishes caught were in mature.

  7. A Novel Protection Method for Single Line-to-Ground Faults in Ungrounded Low-Inertia Microgrids

    Directory of Open Access Journals (Sweden)

    Liuming Jing

    2016-06-01

    Full Text Available This paper proposes a novel protection method for single line-to-ground (SLG faults in ungrounded low-inertia microgrids. The proposed method includes microgrid interface protection and unit protection. The microgrid interface protection is based on the difference between the zero-sequence voltage angle and the zero-sequence current angle at the microgrid interconnection transformer for fast selection of the faulty feeder. The microgrid unit protection is based on a comparison of the three zero-sequence current phase directions at each junction point of load or distributed energy resources. Methods are also included to locate the minimum fault section. The fault section location technology operates according to the coordination of microgrid unit protection. The proposed method responds to SLG faults that may occur in both the grid and the microgrid. Simulations of an ungrounded low-inertia microgrid with a relay model were carried out using Power System Computer Aided Design (PSCAD/Electromagnetic Transients including DC (EMTDC.

  8. On the resonance effects due to ground wires in transmission lines with non-uniform soil conductivity and non-uniform tower resistances

    Energy Technology Data Exchange (ETDEWEB)

    Faria, J.A. B. (Centro de Electrotecnia da Univ. Tecnica de Lisboa, Dept. of Electrical Engineering, Inst. Superior Tecnico, 1096 Lisboa Codex (PT))

    1992-01-01

    High frequency resonance effects due to shield wires grounding may affect carrier transmission performance at the vicinity of certain critical frequencies. In this paper the authors investigate if non-uniformities in soil conductivity and in tower footing resistances along the power line may lead to the suppression of such resonance effects. The simulation results the authors have obtained point towards a negative conclusion.

  9. The phylogenetic position of the Critically Endangered Saint Croix ground lizard Ameiva polops: revisiting molecular systematics of West Indian Ameiva.

    Science.gov (United States)

    Hurtado, Luis A; Santamaria, Carlos A; Fitzgerald, Lee A

    2014-05-06

    The phylogenetic position of the critically endangered Saint Croix ground lizard Ameiva polops is presently unknown and several hypotheses have been proposed. We investigated the phylogenetic position of this species using molecular phylogenetic methods. We obtained sequences of DNA fragments of the mitochondrial ribosomal genes 12S rDNA and 16S rDNA for this species. We aligned these sequences with published sequences of other Ameiva species, which include most of the Ameiva species from the West Indies, three Ameiva species from Central America and South America, and one from the teiid lizard Tupinambis teguixin, which was used as outgroup. We conducted Maximum Likelihood and Bayesian phylogenetic analyses. The phylogenetic reconstructions among the different methods were very similar, supporting the monophyly of West Indian Ameiva and showing within this lineage, a basal polytomy of four clades that are separated geographically. Ameiva polops grouped in a cluster that included the other two Ameiva species found in the Puerto Rican Bank: A. wetmorei and A. exsul. A sister relationship between A. polops and A. wetmorei is suggested by our analyses. We compare our results with a previous study on molecular systematics of West Indian Ameiva. 

  10. Technical note: Sensitivity of instrumental line shape monitoring for the ground-based high-resolution FTIR spectrometer with respect to different optical attenuators

    Science.gov (United States)

    Sun, Youwen; Palm, Mathias; Weinzierl, Christine; Petri, Christof; Notholt, Justus; Wang, Yuting; Liu, Cheng

    2017-03-01

    The TCCON (Total Carbon Column Observing Network) and most NDACC (Network for Detection of Atmospheric Composition Change) sites assume an ideal ILS (instrumental line shape) for analysis of the spectra. In order to adapt the radiant energy received by the detector, an attenuator or different sizes of field stop can be inserted in the light path. These processes may alter the alignment of a high-resolution FTIR (Fourier transform infrared) spectrometer, and may result in bias due to ILS drift. In this paper, we first investigated the sensitivity of the ILS monitoring with respect to application of different kinds of attenuators for ground-based high-resolution FTIR spectrometers within the TCCON and NDACC networks. Both lamp and sun cell measurements were conducted after the insertion of five different attenuators in front of and behind the interferometer. The ILS characteristics derived from lamp and sun spectra are in good agreement. ILSs deduced from all lamp cell measurements were compared. As a result, the disturbances to the ILS of a high-resolution FTIR spectrometer with respect to the insertion of different attenuators at different positions were quantified. A potential strategy to adapt the incident intensity of a detector was finally deduced.

  11. Line positions, pressure broadening and shift coefficients for the second overtone transitions of carbon monoxide in argon

    Science.gov (United States)

    Kowzan, G.; Stec, K.; Zaborowski, M.; Wójtewicz, S.; Cygan, A.; Lisak, D.; Masłowski, P.; Trawiński, R. S.

    2017-04-01

    Absolute positions and spectral line-shape parameters of carbon monoxide 0 → 3 band, P branch transitions are reported. The speed-dependent effects and the influence of velocity-changing collisions were taken into account in the fitted line-shape models. For the first time the values of pressure shift coefficients of CO in argon for this band were determined. The measurements were made with the Pound-Drever-Hall-locked frequency-stabilized cavity ring-down spectrometer, with the frequency axis linked through an optical frequency comb to the UTC(AOS) frequency reference based on a hydrogen maser. Achieved uncertainties of line positions are between 70 kHz and 420 kHz.

  12. A comparative study to evaluate the vertical position of maxillary central incisor and canine in relation to incisive papilla line

    Directory of Open Access Journals (Sweden)

    Mayank Shah

    2014-01-01

    Full Text Available Objectives: The aim of the study was to determine the vertical distance of maxillary central incisor (CI and maxillary canine (CA from the incisive papilla (IP line and their variation with age and sex. Materials and Methods: A total of 120 dentulous subjects following the inclusion and exclusion criteria were randomly selected from the local population. On the basis of gender and age, subjects were divided into four groups: M a , M b , F a and F b . Maxillary impressions of selected subjects were made and corresponding casts were retrieved. The cast was positioned on the surveyor and the center of IP was transferred to the labial side of maxillary right CI and CA regions with the help of analyzing rod of the surveyor and a line was drawn in this region which was referred to as "IP line." The measurements were made from the IP line to the mesio-incisal line angle of right maxillary CI-IP and cusp tip of right maxillary CA with the help of digital vernier caliper (CA to IP. Result: The mean vertical distance of maxillary CI-IP ranged from 6.31 ± 0.74 mm to 7.04 ± 0.87 mm and the mean vertical distance of maxillary CA-IP ranged from 5.83 ± 0.80 mm to 6.30 ± 0.82 mm. Conclusion: The CA position in relation to the IP line is more stable to its position than the CI position irrespective of age and sex.

  13. Development of Speed Car Crossing the Obstacle on the Ground Line%过障碍物地线飞车的研制

    Institute of Scientific and Technical Information of China (English)

    朱理宏

    2015-01-01

    The transmission line maintenance repair work is an important constituent part of the line oper-ation and maintenance work , it is essential to eliminate the line defects and ensure safe and stable opera-tion for the line .When the defect occurs on the ground line , how to cross the obstacles on the ground line in time to eliminate the defects has been one of the major research topics for every company of operation and maintenance for lines .This article describes the principle , the development process and the key technology of speed car crossing the obstacles on the ground line , and it has great value for the elimina-tion of similar defects in the future .%输电线路检修工作是线路运维工作的一个重要工作组成部分,对于消除线路缺陷,确保线路安全稳定运行至关重要。当缺陷出现在地线上的时候,如何跨越地线上的障碍物及时消缺一直是各线路运行维护单位主要的研究课题之一。文章介绍了过障碍物地线飞车研制的原理、研制过程及关键技术,对以后类似缺陷的消除具有比较好的应用价值。

  14. Development of the Spring-Hook Grounding Line of EHV/UHV Transmission Line%超(特)高压线路弹压式钩型接地线的研制

    Institute of Scientific and Technical Information of China (English)

    晏节晋; 张振威

    2015-01-01

    An important measure is that to hang grounding lines to protect electric operators from electric shock injury in the interruption maintenance of transmission lines .There are some difficulties and security risks in the process of the use of common grounding lines , especially even worse in EHV/UHV transmis-sion line .But this spring-hook grounding line is more simple and convenient , more efficient and safer in the process of hanging and removing .%输电线路停电检修时,一项重要保护措施就是挂设接地线,以保证检修人员在检修过程中免遭触电伤害。而比较常见的接地线在使用过程中存在一定的困难和安全隐患,特别是在超(特)高压输电线路上,尤为明显,而研制的弹压式钩型接地线在挂设、拆除过程中简单方便、工作效率较高、安全性大大提高。

  15. Asbestos fibres in the lungs of an American mechanic who drilled, riveted, and ground brake linings: a case report and discussion.

    Science.gov (United States)

    Finkelstein, Murray M

    2015-05-01

    In North America and Europe, the use of asbestos in friction products was discontinued before the end of the 20th century. In the developing world, the use of asbestos-containing friction products continues. In 2010, Cely-Garcia and colleagues (Cely-Garcia et al., 2012) sampled three brake repair shops located in Bogota, Colombia. Both asbestos and non-asbestos containing brake linings were sold separately or attached to a shoe. When brake linings are sold separated from the shoe, they must be manipulated to attach them to the shoe before installation. The process starts with the removal of the old brake shoe from the vehicle's brake drum. If the existing brake shoe is to be reused, the old lining needs to be removed and the old shoe must be ground to prepare it for a new lining. Riveting requires drilling holes in the linings and shoes and before installing rivets, the lining must be countersunk. The borders of the lining are bevelled. On some occasions, the entire exposed surface of the lining is ground to make it thinner. Once attached to the shoe, the edges of brake linings may extend beyond the shoe. In this case, it is necessary to cut or grind the edges to match the lining to the shoe before bevelling or grinding. The authors reported that 'the sampling results indicate that the brake mechanics sampled are exposed to extremely high asbestos concentrations (i.e. based on transmission electron microscopy counts), suggesting that this occupational group could be at excess risk of asbestos-related diseases'.

  16. Selective mobilization of saturated fatty acids in isolated adipocytes of hibernating 13-lined ground squirrels Ictidomys tridecemlineatus.

    Science.gov (United States)

    Price, Edwin R; Armstrong, Christopher; Guglielmo, Christopher G; Staples, James F

    2013-01-01

    Fatty acids are not mobilized from adipocyte triacylglycerols uniformly but rather some are preferentially mobilized while others are preferentially retained. In many vertebrate species, the pattern of differential mobilization is determined by the physical and chemical properties of each fatty acid. Fatty acids with shorter chains and more double bonds tend to be more readily mobilized than others, a pattern observed both in whole-animal studies and in isolated adipocytes. Several hibernating species seem to break this pattern, however, and retain 18:2ω6 (linoleic acid) while mobilizing saturated fatty acids such as 18:0. We sought to confirm this pattern in adipocytes of a hibernator, the 13-lined ground squirrel Ictidomys tridecemlineatus, and to investigate mobilization patterns for the first time at hibernation temperature. We isolated adipocytes from summer active and winter torpid squirrels and incubated them with 1 μM norepinephrine at 4°C (7 h) and 37°C (90 min). We measured the proportion of each fatty acid in the adipose tissue and in the buffer at the end of incubation. Patterns of mobilization were similar in both seasons and incubation temperatures. Saturated fatty acids (18:0 and 16:0) were highly mobilized relative to the average, while some unsaturated fatty acids (notably, 18:1ω9 and 18:2ω6) were retained. We conclude that hibernators have unique mechanisms at the level of adipose tissue that preferentially mobilize saturated fatty acids. Additionally, we found that adipocytes from hibernating squirrels produced more glycerol than those from summer squirrels (regardless of temperature), indicating a higher lipolytic capacity in hibernating squirrels.

  17. Study of improvement of indices maize line to establish their position in hybrids

    Directory of Open Access Journals (Sweden)

    Oxana DIRZU-COCOS

    2015-12-01

    Full Text Available Corn (Zea mays L. crop that is grown on large areas - over 140 million hectares worldwide, and 400-500 thousand ha in Moldova due to production potential broad diversity of use as food for humans, animals, birds raw material for industrial processing. The upward trend in average yields achieved is largely attributed to the improvement of scientific programs. Select the line with the characters and traits that are transmitted hereditary hybrids and contribute to their performance, ensure progress in improvement. Therefore, the process of creating inbred lines associated with combining ability testing as a measure of productivity conferred hybrids, is significant research programs. Orientation purpose of improved maize hybrids to formulas and simple change to a superior capitalization heterosis effect and perfect uniformity of plant requires changes in methodology for the creation, evaluation and classification of inbred lines.

  18. One-End Data Method for Fault Position Estimate of Two-Parallel Transmission Lines

    Institute of Scientific and Technical Information of China (English)

    张庆超; 刘飞; 武永峰; 宋文南

    2003-01-01

    An accurate numerical algorithm for three-line fault involving different phases from each of two-parallel lines is presented. It is based on one-terminal voltage and current data. The loop and nodel equations comparing faulted phase to non-faulted phase of two-parallel lines are introduced in the fault location estimation modal, in which the faulted impedance of remote end is not involved. The effect of load flow and fault resistance on the accuracy of fault location are effectively eliminated, therefore an accurate algorithm of locating fault is derived. The algorithm is demonstrated by digital computer simulations and the results show that errors in locating fault are less than 1%.

  19. A grounded theory of positive youth development through sport based on results from a qualitative meta-study

    Science.gov (United States)

    Holt, Nicholas L.; Neely, Kacey C.; Slater, Linda G.; Camiré, Martin; Côté, Jean; Fraser-Thomas, Jessica; MacDonald, Dany; Strachan, Leisha; Tamminen, Katherine A.

    2017-01-01

    ABSTRACT The overall purpose of this study was to create a model of positive youth development (PYD) through sport grounded in the extant qualitative literature. More specifically, the first objective was to review and evaluate qualitative studies of PYD in sport. The second objective was to analyze and synthesize findings from these studies. Following record identification and screening, 63 articles were retained for analysis. Meta-method analysis revealed strengths of studies were the use of multiple data collection and validity techniques, which produced high-quality data. Weaknesses were limited use of ‘named’ methodologies and inadequate reporting of sampling procedures. Philosophical perspectives were rarely reported, and theory was used sparingly. Results of an inductive meta-data analysis produced three categories: PYD climate (adult relationships, peer relationships, and parental involvement), life skills program focus (life skill building activities and transfer activities), and PYD outcomes (in personal, social, and physical domains). A model that distinguishes between implicit and explicit processes to PYD is presented. PMID:27695511

  20. GEANT4 simulation diagram showing the architecture of the ATLAS test line: the detectors are positioned to receive the beam from the SPS. A muon particle which enters the magnet and crosses all detectors is shown (blue line).

    CERN Multimedia

    2004-01-01

    GEANT4 simulation diagram showing the architecture of the ATLAS test line: the detectors are positioned to receive the beam from the SPS. A muon particle which enters the magnet and crosses all detectors is shown (blue line).

  1. A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe

    DEFF Research Database (Denmark)

    Mocroft, A; Reiss, P; Rakhmanova, A

    2014-01-01

    ATRIPLA is licensed for use only in HIV-positive persons whose viral loads therapy (ART) in EuroSIDA using a web-based survey performed in Autumn 2012. 96/112 clinics (85.7 %) completed the survey. Recommendations...... when initiating first-line ART was TRUVADA plus efavirenz in 36 (37.5 %), ATRIPLA in 35 (36.5 %), a different first-line regimen in 12 clinics (12.5 %), and no recommendation in 7 clinics (7.3 %). ATRIPLA was commonest in Northern (15/21 clinics; 71.4 %), and least common in Eastern Europe (2....../31 clinics; 6.5 %; p therapy, despite EMA recommendations....

  2. Hospital takes customer service to new level, sees positive effect on bottom line.

    Science.gov (United States)

    1997-06-01

    Service with a smile boosts bottom line. Treating co-workers and patients like guests is the linchpin of a whole new philosophy at Bradley Memorial Hospital in Cleveland, TN. Administrators there insist a host of new customer service programs, from cap and gown graduation ceremonies to bunny bucks, has resulted in dramatic financial improvements and more satisfied patients and staff.

  3. Outburst of GX304-1 Monitored with INTEGRAL: Positive Correlation Between the Cyclotron Line Energy and Flux

    Science.gov (United States)

    Klochkov, D.; Doroshenko, V.; Santangelo, A.; Staubert, R.; Ferrigno, C.; Kretschmar, P.; Caballero, I.; Wilms, J.; Kreykenbohm, I.; Pottschmidt, I.; hide

    2012-01-01

    Context. X-ray spectra of many accreting pulsars exhibit significant variations as a function of flux and thus of mass accretion rate. In some of these pulsars, the centroid energy of the cyclotron line(s), which characterizes the magnetic field strength at the site of the X-ray emission, has been found to vary systematically with flux. Aims. GX304-1 is a recently established cyclotron line source with a line energy around 50 keV. Since 2009, the pulsar shows regular outbursts with the peak flux exceeding one Crab. We analyze the INTEGRAL observations of the source during its outburst in January-February 2012. Methods. The observations covered almost the entire outburst, allowing us to measure the source's broad-band X-my spectrum at different flux levels. We report on the variations in the spectral parameters with luminosity and focus on the variations in the cyclotron line. Results. The centroid energy of the line is found to be positively correlated with the luminosity. We interpret this result as a manifestation of the local sub-Eddington (sub-critical) accretion regime operating in the source.

  4. Positive Psychology in Cancer Care : A Story Line Resistant to Evidence

    NARCIS (Netherlands)

    Coyne, James C.; Tennen, Howard; Ranchor, Adelita V.

    2010-01-01

    Aspinwall and Tedeschi (Ann Behav Med, 2010) summarize evidence they view as supporting links between positive psychological states, including sense of coherence (SOC) and optimism and health outcomes, and they refer to persistent assumptions that interfere with understanding how positive states pre

  5. Post-LGM grounding line and calving front translations of the West Antarctic Ice Sheet in the Whales Deep paleo-ice-stream trough, eastern Ross Sea, Antarctica

    Science.gov (United States)

    McGlannan, A. J.; Bart, P. J.; Chow, J.

    2016-12-01

    A large-area (2500 km2) multibeam survey of the Whales Deep paleo-ice-stream trough, eastern Ross Sea, Antarctica was acquired during NBP1502B. This sector of the continental shelf is important as it was covered by grounded and floating ice, which drained the central part of an expanded West Antarctic Ice Sheet (WAIS) during the last glacial cycle. The seafloor geomorphology shows a well-defined cluster of four back stepping grounding zone wedges (GZWs) that were deposited in a partly overlapping fashion on the middle continental shelf during WAIS retreat. These observations permit two end-member possibilities for how the WAIS grounding line and calving front vacated the trough. In the first scenario, each GZW represents successive landward shifts of the grounding line and calving front. In the second scenario, each GZW represents a large-scale retreat and re-advance of grounded and floating ice. To determine which of these two end-member scenarios most accurately describes WAIS retreat from this sector of Ross Sea, we evaluated a grid of kasten and piston cores. The core stations were selected on the basis of backstepping GZWs along the trough axis. Our core data analyses included an integration of visual core descriptions, x-ray images, grain size, water content, total organic carbon, shear strengths, and diatom assemblage data. Core data reveal a single transgressive succession from proximal diamict overlain by sub-ice-shelf and/or open-marine sediments. These data strongly support the first scenario, suggesting that an ice shelf remained continuously intact during the time that the grounding line successively moved from the shelf edge to the middle shelf by small-scale landward translations until the end of the fourth grounding event. Sedimentologic and diatom-assemblage data from the inner shelf show that only the last middle shelf grounding event ended with a long-distance retreat of grounded and then floating ice to south of the modern calving front.

  6. Application of robot kinematics methods to the simulation and control of neutron beam line positioning systems

    Energy Technology Data Exchange (ETDEWEB)

    James, Jonathan A. [Open University, Materials Engineering, Walton Hall, Milton Keynes, Buckinghamshire MK7 6AA (United Kingdom)]. E-mail: j.a.j.james@open.ac.uk; Edwards, Lyndon [Open University, Materials Engineering, Walton Hall, Milton Keynes, Buckinghamshire MK7 6AA (United Kingdom)

    2007-02-11

    Neutron stress measurements require specimens of complex geometry to be speedily and accurately positioned and oriented with respect to the neutron beam. Recognition that a majority of the specimen positioning systems in use at strain scanning facilities are effectively serial robot manipulators, suggests that the methods of serial robot kinematic modelling may be applied to advantage. The adoption of robotics methods provides a simple and reliable framework for controlling positioning systems of arbitrary geometry and complexity. In addition the numerical solution of the inverse kinematic problem is facilitated, allowing specimens to be automatically positioned and orientated so that pre-determined strain components are measured. It is also shown that, given sufficient degrees of freedom, a secondary characteristic of the measurement position such as the measurement count time may be simultaneously optimised.

  7. Experimental models for the study of drug resistance in osteosarcoma: P-glycoprotein-positive, murine osteosarcoma cell lines.

    Science.gov (United States)

    Takeshita, H; Gebhardt, M C; Springfield, D S; Kusuzaki, K; Mankin, H J

    1996-03-01

    P-glycoprotein is an adenosine triphosphate-dependent drug-efflux pump that extrudes drugs from cells and causes drug-resistance. P-glycoprotein is believed to mediate drug-resistance in a wide variety of tumors. In this study, we developed two P-glycoprotein-positive, murine osteosarcoma cell lines that were resistant to Adriamycin (doxorubicin) (MOS/ADR1 and MOS/ADR2). We created the cell lines by short-term pulse exposures of the parent cell line to Adriamycin followed by single-cell cloning. The MOS/ADR1 and MOS/ADR2 cells were sevenfold and eighteenfold more resistant to Adriamycin than the cells from the parent line. Expression of P-glycoprotein, as examined with an immunofluorescence method, was detected in most of the MOS/ADR1 and MOS/ADR2 cells but not in the parent cells. After the cells had been incubated with Adriamycin for one hour, there was less accumulation of the drug in the resistant cell lines than in the parent cell line. The reduced accumulation was due to the increased efflux of Adriamycin. The Adriamycin-resistant cell lines demonstrated greater alkaline phosphatase activity than the parent cell line and produced more differentiated osteoblastic sarcomas in mice. Dose survival studies with use of a tetrazolium colorimetric assay showed that the MOS/ADR1 cells were cross-resistant to vincristine, vinblastine, etoposide, bleomycin, mitomycin C, and actinomycin D but not to dacarbazine, cisplatin, carboplatin, cytosine arabinoside, carmustine, cyclophosphamide, ifosfamide, methotrexate, and 5-fluorouracil. Although the MOS/ADR2 cells exhibited a similar spectrum of cross-resistance, they were more resistant than the MOS/ADR1 cells. We also tested the effect of three different resistance-modifying agents on the reversal of resistance to Adriamycin. We found that verapamil and trifluoperazine substantially reversed resistance to Adriamycin in the P-glycoprotein positive cell lines, whereas cyclosporin A was relatively ineffective. Because these

  8. The direct determination of double bond positions in lipid mixtures by liquid chromatography/in-line ozonolysis/mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Chenxing; Zhao, Yuan-Yuan [Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5 (Canada); Curtis, Jonathan M., E-mail: jcurtis1@ualberta.ca [Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5 (Canada)

    2013-01-31

    Highlights: ► An ozonolysis reactor was coupled in-line with mass spectrometry (O{sub 3}-MS). ► Double bond positions in FAME were determined unambiguously without standards. ► LC directly connected to O{sub 3}-MS allowed double bond localization in lipid mixtures. ► LC/O{sub 3}-MS applied to bovine fat demonstrated practical use in lipid analysis. -- Abstract: The direct determination of double bond positions in unsaturated lipids using in-line ozonolysis-mass spectrometry (O{sub 3}-MS) is described. In this experiment, ozone penetrates through the semi-permeable Teflon AF-2400 tubing containing a flow of a solution of fatty acid methyl esters (FAME). Unsaturated FAME are thus oxidized by the ozone and cleaved at the double bond positions. The ozonolysis products then flow directly into the atmospheric pressure photoionization (APPI) source of a mass spectrometer for analysis. Aldehyde products retaining the methyl ester group are indicative of the double bond positions in unsaturated FAME. For the first time, O{sub 3}-MS is able to couple directly to high performance liquid chromatography (HPLC), making the double bond localization in lipid mixtures possible. The application of LC/O{sub 3}-MS has been demonstrated for a fat sample from bovine adipose tissue. A total of 9 unsaturated FAME including 6 positional isomers were identified unambiguously, without comparison to standards. The in-line ozonolysis reaction apparatus is applicable to most mass spectrometers without instrumental modification; it is also directly compatible with various LC columns. The LC/O{sub 3}-MS method described here is thus a practical, versatile and easy to use new approach to the direct determination of double bond positions in lipids, even in complex mixtures.

  9. The effect of on-line position correction on the dose distribution in focal radiotherapy for bladder cancer

    Directory of Open Access Journals (Sweden)

    Koning Caro CE

    2009-09-01

    Full Text Available Abstract Background The purpose of this study was to determine the dosimetric effect of on-line position correction for bladder tumor irradiation and to find methods to predict and handle this effect. Methods For 25 patients with unifocal bladder cancer intensity modulated radiotherapy (IMRT with 5 beams was planned. The requirement for each plan was that 99% of the target volume received 95% of the prescribed dose. Tumor displacements from -2.0 cm to 2.0 cm in each dimension were simulated, using 0.5 cm increments, resulting in 729 simulations per patient. We assumed that on-line correction for the tumor was applied perfectly. We determined the correlation between the change in D99% and the change in path length, which is defined here as the distance from the skin to the isocenter for each beam. In addition the margin needed to avoid underdosage was determined and the probability that an underdosage occurs in a real treatment was calculated. Results Adjustments for tumor displacement with perfect on-line position correction resulted in an altered dose distribution. The altered fraction dose to the target varied from 91.9% to 100.4% of the prescribed dose. The mean D99% (± SD was 95.8% ± 1.0%. There was a modest linear correlation between the difference in D99% and the change in path length of the beams after correction (R2 = 0.590. The median probability that a systematic underdosage occurs in a real treatment was 0.23% (range: 0 - 24.5%. A margin of 2 mm reduced that probability to Conclusion On-line position correction does result in an altered target coverage, due to changes in average path length after position correction. An extra margin can be added to prevent underdosage.

  10. Looking for a Silver Lining: The Possible Positives of Declining Energy Return on Investment (EROI

    Directory of Open Access Journals (Sweden)

    Jack P. Manno

    2011-10-01

    Full Text Available Declining energy return on investment (EROI of a society’s available energy sources can lead to both crisis and opportunity for positive social change. The implications of declining EROI for human wellbeing are complex and open to interpretation. There are many reasons why frugal living and an energy diet could be beneficial. A measure of wellbeing or welfare gained per unit of energy expended (WROEI is proposed. A threshold is hypothesized for the relation between energy consumption and wellbeing. The paper offers a biophysical-based social science explanation for both the negative and positive possible implications of declining EROI. Two sets of future scenarios based on environmental and economic trends are described. Six types of social change activism are considered essential if the positives of declining EROI are to balance or exceed the negatives.

  11. Line positions and intensities of the phosphine (PH3) Pentad near 4.5μm

    Energy Technology Data Exchange (ETDEWEB)

    Malathy Devi, V.; Kleiner, Isabelle; Sams, Robert L.; Brown, Linda R.; Benner, D. Chris; Fletcher, Leigh N.

    2014-04-01

    In order to improve the spectroscopic database for remote sensing of the giant planets, line positions and intensities are determined for the five bands (2ν2, ν2 + ν4, 2ν4, ν1 and ν3) that comprise the Pentad of PH3 between 1950 and 2450 cm-1. Knowledge of PH3 spectral line parameters in this region is important for the exploration of dynamics and chemistry on Saturn, (using existing Cassini/VIMS observations) and future near-IR data of Jupiter from Juno and ESA’s Jupiter Icy Moons Explorer (JUICE). For this study, spectra of pure PH3 from two Fourier transform spectrometers were obtained: (a) five high-resolution (0.00223 cm-1), high signal-to-noise (~1800) spectra recorded at room temperature (298.2 K) with the Bruker IFS 125HR Fourier transform spectrometer (FTS) at the Pacific Northwest National Laboratory (PNNL), Richland, Washington and (b) four high-resolution (at 0.0115 cm-1 resolution), high signal-to-noise (~700) spectra recorded at room temperature in the region 1800–5200 cm-1 using the McMath-Pierce Fourier transform spectrometer located at the National Solar Observatory (NSO) on Kitt Peak. Individual line parameters above 2150 cm-1 were retrieved by simultaneous multispectrum fittings of all five Bruker spectra, while retrievals with the four Kitt Peak spectra were done in the 1938–2168 cm-1 range spectrum by spectrum and averaged. In all, positions and intensities were obtained for more than 4400 lines. These included 53 A+A- split pairs of transitions (arising due to vibration–rotation interactions (Coriolis-type interaction) between the ν3 and ν1 fundamental bands) for K" = 3, 6, and 9. Over 3400 positions and 1750 intensities of these lines were ultimately identified as relatively unblended and modeled up to J = 14 and K = 12 with rms values of 0

  12. Raw and processed ground-penetrating radar and postprocessed differential global positioning system data collected from Assateague Island, Maryland, October 2014

    Science.gov (United States)

    Zaremba, Nicholas J.; Bernier, Julie C.; Forde, Arnell S.; Smith, Christopher G.

    2016-06-08

    Scientists from the U.S. Geological Survey, St. Petersburg Coastal and Marine Science Center acquired sediment cores, sediment surface grab samples, ground-penetrating radar (GPR) and Differential Global Positioning System (DGPS) data from Assateague Island, Maryland, in October 2014. The objectives were to identify washover deposits in the stratigraphic record to aid in understanding barrier island evolution.

  13. Moisture Analysis of a Squall Line Case Based on Precipitable Water Vapor Data from a Ground-Based GPS Network in the Yangtze River Delta

    Institute of Scientific and Technical Information of China (English)

    DING Jincai; YANG Yinming; YE Qixin; HUANG Yan; MA Xiaoxing; MA Leiming; Y.R.GUO

    2007-01-01

    A squall line swept eastward across the area of the Yangtze River Delta and produced gusty winds and heavy rain from the afternoon to the evening of 24 August 2002. In this paper, the roles of moisture in the genesis and development of the squall line were studied. Based on the precipitable water vapor (PWV) data from a ground-based GPS network over the Yangtze River Delta in China, plus data from a Pennsylvania State University/National Atmospheric Center (PSU/NCAR) mesoscale model (MM5) simulation, initialized by three-dimensional variational (3D-VAR) assimilation of the PWV data, some interesting features are revealed. During the 12 hours prior to the squall line arriving in the Shanghai area, a significant increase in PWV indicates a favorable moist environment for a squall line to develop. The vertical profile of the moisture illustrates that it mainly increased in the middle levels of the troposphere, and not at the surface. Temporal variation in PWV is a better precursor for squall line development than other surface meteorological parameters. The characteristics of the horizontal distribution of PWV not only indicated a favorable moist environment, but also evolved a cyclonic wind field for a squall line genesis and development. The "+2 mm" contours of the three-hourly PWV variation can be used successfully to predict the location of the squall line two hours later.

  14. Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer

    DEFF Research Database (Denmark)

    Hortobagyi, G. N.; Stemmer, S. M.; Burris, H. A.

    2016-01-01

    BACKGROUND The inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) could potentially overcome or delay resistance to endocrine therapy in advanced breast cancer that is positive for hormone receptor (HR) and negative for human epidermal growth factor receptor 2 (HER2). METHODS In this randomi...

  15. Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines

    Directory of Open Access Journals (Sweden)

    Pan Zhongzong

    2009-01-01

    Full Text Available Abstract Background Estrogen receptor-α (ERα is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands and the majority of primary breast tumors, it is generally believed that paracrine regulation is involved in ERα mediated cell proliferation. In the paracrine model, ERα-positive cells don't proliferate but will release some paracrine growth factors to stimulate the neighboring cells to proliferate. In a subpopulation of cancer cells in some primary breast tumors, however, ERα does colocalize with the cell proliferation marker Ki-67, suggesting an autocrine regulation by ERα in some primary breast tumors. Methods Colocalization of ERα with Ki-67 in ERα-positive breast cancer cell lines (MCF-7, T47D, and ZR75-1 was evaluated by immunofluorescent staining. Cell cycle phase dependent expression of ERα was determined by co-immunofluorescent staining of ERα and the major cyclins (D, E, A, B, and by flow cytometry analysis of ERαhigh cells. To further confirm the autocrine action of ERα, MCF-7 cells were growth arrested by ICI182780 treatment, followed by treatment with EGFR inhibitor, before estrogen stimulation and analyses for colocalization of Ki-67 and ERα and cell cycle progression. Results Colocalization of ERα with Ki-67 was present in all three ERα-positive breast cancer cell lines. Unlike that in the normal mammary glands and the majority of primary breast tumors, ERα is highly expressed throughout the cell cycle in MCF-7 cells. Without E2 stimulation, MCF-7 cells released from ICI182780 treatment remain at G1 phase. E2 stimulation of ICI182780 treated cells, however, promotes the expression and colocalization of ERα and Ki-67 as well as the cell cycle progressing through the S and G2/M phases. Inhibition of EGFR signaling does not inhibit the autocrine action of ERα. Conclusion Our data indicate

  16. Buccolingual implant position and vertical abutment finish line geometry: two strictly related factors that may influence the implant esthetic outcome.

    Science.gov (United States)

    Scutellà, Fabio; Weinstein, Tommaso; Lazzara, Richard; Testori, Tiziano

    2015-06-01

    Three-dimensional implant positioning has always been a highly debated topic especially in the esthetic zone due to many problems related to buccal bone resorption. A new concept in implant position, dictated by changing the abutment finish line, is presented in the following article. The actual guidelines on implant position agree that in the bucco-palatal dimension, the implant should be placed more toward the palatal preserving at least 2 mm of buccal bone. However, changing the abutment finish line geometry from horizontal to vertical, the authors' geometry of choice, the surgical approach in the bucco-palatal direction has been modified accordingly to ensure final restorations that will guarantee long-term soft tissue stability. The emergence angle of the natural teeth has been the authors' guide to establish the implant position which should be located with the long axis of the implant corresponding to the incisal edge of the future restoration. Observation of the clinical results in the past years strongly supports this approach. The surgical and prosthetic concepts described in this article allow the clinician to recreate a pleasant and natural-looking esthetics while the patient can easily maintain a proper hygiene around the implant. However, despite the promising clinical results obtained by the authors, further clinical and randomized researches should be realized to validate the above-proposed approach.

  17. Engineering Calculation Method of Electromagnetic Effect on Oil/Gas Pipelines from 1 000 kV AC Transmission Line Having Single-phase Ground Fault

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wenliang; JIANG Jun; GUO Jian; LU Jiayu

    2012-01-01

    There will be more and more AC transmission lines near oil/gas pipelines in the future.So in order to determine the safe distance between them,simple and effective methods are required for engineers to efficiently evaluate the electromagnetic effect on oil/gas pipelines due to faults of AC transmission lines.In this paper,an easily handled fitting formula is obtained based on multiple calculation results,which is the maximum voltage on the pipeline anticorrosive coating produced by 1 000 kV AC transmission line under single phase ground fault.Although the calculation results obtained from the fitting formula differ from those gained by precise calculation with softwares,the verification of the formula shows that it is applicable for engineering calculation.This research could be applied to evaluate the electromagnetic effect of 1 000 kV AC transmission line under single-phase ground fault on nearby pipelines,as well as to determine the safe distance or the maximum parallel length.

  18. A Review on Level of Specific Absorption Rate Due to High Power Transmission Lines: Analysis toward Human Position Posture

    Directory of Open Access Journals (Sweden)

    Ghazali Z.

    2016-01-01

    Full Text Available The main contribution of this project is the development of a homogeneous model of a man to presents the specific absorption rate (SAR due to high power transmission line. As a low frequency application under high power transmission line of 50 Hz in electrical engineering, to studies the influence of human’s posture on specific absorption rate. This project designs two types of human body which one design uses most cylinder block and another design use brick block where both blocks have a different value of mesh cells. For each design has four types of posture are standing, sitting, arms up and arms out by using Computer Simulation Technology (CST Studio Software. This analysis does toward for four types of the human position postures because each posture has different value of specific absorption rate (SAR based on the size of the mesh cells of the design. Based on two designs of the human body, the lowest of the mesh cells value will reduce time to simulate SAR. For each posture has different value of SAR for each part of the human body because the whole human body has different types of tissues. Therefore, the CST studio software uses extremely to simulate the SAR value toward human position posture due to high power transmission line.

  19. Dissecting the Power Sources of Low-Luminosity Emission-Line Galaxy Nuclei via Comparison of HST-STIS and Ground-Based Spectra

    Science.gov (United States)

    Constantin, Anca; Shields, Joseph C.; Ho, Luis C.; Barth, Aaron J.; Filippenko, Alexei V.; Castillo, Christopher A.

    2015-12-01

    Using a sample of ∼100 nearby line-emitting galaxy nuclei, we have built the currently definitive atlas of spectroscopic measurements of Hα and neighboring emission lines at subarcsecond scales. We employ these data in a quantitative comparison of the nebular emission in Hubble Space Telescope (HST) and ground-based apertures, which offer an order-of-magnitude difference in contrast, and provide new statistical constraints on the degree to which transition objects and low-ionization nuclear emission-line regions (LINERs) are powered by an accreting black hole at ≲10 pc. We show that while the small-aperture observations clearly resolve the nebular emission, the aperture dependence in the line ratios is generally weak, and this can be explained by gradients in the density of the line-emitting gas: the higher densities in the more nuclear regions potentially flatten the excitation gradients, suppressing the forbidden emission. The transition objects show a threefold increase in the incidence of broad Hα emission in the high-resolution data, as well as the strongest density gradients, supporting the composite model for these systems as accreting sources surrounded by star-forming activity. The narrow-line LINERs appear to be the weaker counterparts of the Type 1 LINERs, where the low accretion rates cause the disappearance of the broad-line component. The enhanced sensitivity of the HST observations reveals a 30% increase in the incidence of accretion-powered systems at z ≈ 0. A comparison of the strength of the broad-line emission detected at different epochs implies potential broad-line variability on a decade-long timescale, with at least a factor of three in amplitude. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the data archive at the Space Telescope Science Institute. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555.

  20. DISSECTING THE POWER SOURCES OF LOW-LUMINOSITY EMISSION-LINE GALAXY NUCLEI VIA COMPARISON OF HST-STIS AND GROUND-BASED SPECTRA

    Energy Technology Data Exchange (ETDEWEB)

    Constantin, Anca; Castillo, Christopher A. [Department of Physics and Astronomy, James Madison University, Harrisonburg, VA 22807 (United States); Shields, Joseph C. [Department of Physics and Astronomy, Ohio University, Athens, OH 45701 (United States); Ho, Luis C. [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Barth, Aaron J. [Department of Physics and Astronomy, University of California, Irvine, CA 92697-4575 (United States); Filippenko, Alexei V. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States)

    2015-12-01

    Using a sample of ∼100 nearby line-emitting galaxy nuclei, we have built the currently definitive atlas of spectroscopic measurements of Hα and neighboring emission lines at subarcsecond scales. We employ these data in a quantitative comparison of the nebular emission in Hubble Space Telescope (HST) and ground-based apertures, which offer an order-of-magnitude difference in contrast, and provide new statistical constraints on the degree to which transition objects and low-ionization nuclear emission-line regions (LINERs) are powered by an accreting black hole at ≲10 pc. We show that while the small-aperture observations clearly resolve the nebular emission, the aperture dependence in the line ratios is generally weak, and this can be explained by gradients in the density of the line-emitting gas: the higher densities in the more nuclear regions potentially flatten the excitation gradients, suppressing the forbidden emission. The transition objects show a threefold increase in the incidence of broad Hα emission in the high-resolution data, as well as the strongest density gradients, supporting the composite model for these systems as accreting sources surrounded by star-forming activity. The narrow-line LINERs appear to be the weaker counterparts of the Type 1 LINERs, where the low accretion rates cause the disappearance of the broad-line component. The enhanced sensitivity of the HST observations reveals a 30% increase in the incidence of accretion-powered systems at z ≈ 0. A comparison of the strength of the broad-line emission detected at different epochs implies potential broad-line variability on a decade-long timescale, with at least a factor of three in amplitude.

  1. Pressure-Induced Shifts of R, R', and B Line-Groups and Ground-State Zero-Field-Splitting of Ruby

    Institute of Scientific and Technical Information of China (English)

    MA Dong-Ping; CHEN Ju-Rong

    2005-01-01

    By means of improved ligand-field theory, the "pure electronic" presure-induced shifts (PS's) and the PS's due to electron-phonon interaction (EPI) of the R1, R2, B1, B2, B3, and R'3 lines and the ground-state zero-field-splitting of ruby have been uniformly calculated. The calculation results are in very good agreement with all the experimental data. At normal pressure, ruby is a crystal with very strong crystal field. Thus, the admixture of |t22 (3T1)e4T2> and |t3 2 2 E> bases in the wavefunction of R1 level of ruby is small at normal pressure, and it gradually decreases with increasing pressure, which causes the R1-line PS of ruby to monotonously red shift with approximate linearity. The combined effect of the pure electronic PS of R1 line and the PS of R1 line due to EPI gives rise to the total PS of R1 line. The analyses and comparisons among the features of R1-line PS's of three laser crystals (ruby, GSGG:Cr3+ and GGG:Cr3+ ) have been made, and the origin of their difference has been revealed.

  2. Contact wire positions and contact forces. Measurements at high-speed lines in China; Fahrdrahtlage und Kontaktkraefte. Messungen an Hochgeschwindigkeitsstrecken in China

    Energy Technology Data Exchange (ETDEWEB)

    Heland, Joerg; Rick, Frank; Sarnes, Bernhard [DB Systemtechnik GmbH, Muenchen (Germany); Puschmann, Rainer [Siemens AG, Erlangen (Germany). Infrastructure and Cities

    2012-07-15

    The reliable energy transmission from overhead contact line to pantograph of traction units without interruption decides on the successful operation of high-speed railway lines. Measurements of contact wire position and contact forces are suited to assess interaction of overhead contact line and pantograph. Chinese Railways actually implement the biggest electrification program for high-speed lines worldwide. For these projects contact wire position and contact forces are monitored by procedures developed in Germany. The experience confirms that keeping the contact wire position within the specified limits lead to a superior energy transmission up to 350 km/h. (orig.)

  3. Molecular glass positive i-line photoresist materials containing 2,1,4-DNQ and acid labile group

    Science.gov (United States)

    Wang, Liyuan; Yu, Jinxing; Xu, Na

    2010-04-01

    Recent years increasing attention has been given to molecular glass resist materials. In this paper, maleopimaric acid, cycloaddition reaction product of rosin with maleic anhydride, was reacted with hydroxylamine and then further esterified with 2-diazo-1-naphthoquinone-4-sulfonyl chloride to give N-hydroxy maleopimarimide sulfonate. The carboxylic acid group of the compound was then protected by the reaction of this compound with vinyl ethyl ether or dihydropyran. Thus obtained compounds were amorphous. When irradiated with i-line light, the 2,1,4-DNQ group undergo photolysis not only to give off nitrogen gas but also generate sulfonic acid which can result in the decomposition of the acid labile group. So, a novel chemically amplified positive i-line molecular glass photoresists can be formed by the compound and other acidolytic molecular glass compounds. The lithographic performance of the resist materials is evaluated.

  4. The hydro- and multi-isotope geochemistry of iron-rich ground waters emerging at the southern Baltic Sea coast line

    Science.gov (United States)

    Lipka, Marko; Wu, Zijun; Escher, Peter; Struck, Ulrich; Dellwig, Olaf; Schafmeister, Maria; Böttcher*, Michael E.

    2013-04-01

    Iron-rich groundwater springs emerging at the shore zone of the southern Baltic Sea (BS; Site Meschendorf) were examined on a seasonal base for a period of about two years. Besides major, minor, and trace elements, stable isotopes of water (H-2, O-18), dissolved inorganic carbon (DIC; C-13), and sulfate (S-34) were analyzed. The stream bed sediment was extracted for the geochemistry of the newly formed precipitates and further characterized via SEM-EDAX. Subsequently, the hydrogeochemical results were subjected to a thermodynamic analysis via the PHREEQC speciation model. The springs emerge from small pits (about 60 cm diameter; up to 15cm depth). Surrounding sediments are sandy with gravels found at depth and corresponding high permeabilities. The positions of different springs on the shore zone were stable during the investigation period while the shape of the pits and the stream beds may vary due to wind- and wave-driven forces. Selected measurements of spring yield discharges close to 10 L/min. The H-2 and O-18 contents of the spring waters indicate the ground water to originate from relatively young mixed meteoric waters. The hydrochemistry of the springs was similar and showed some variability in between which indicates that the genetic processes for the ground water before reaching the surface may slightly differ. The springs are characterized by dissolved Ca, Mg, Na, DIC and sulfate, mainly reflecting the interaction with soils and bedrocks in the recharge area that is dominated by marly till. The oxygen-free ground water is rich in Fe, P, and DIC. Iron and dissolved sulfate originate from the oxidation of pyrite, as further confirmed by the 34-S signature of sulfate. The carbon isotope signature of DIC indicates a mixture of biogenic CO2 from the soil zone with some water-rock interaction with carbonate minerals. The streams flow towards the BS and, in contact with the atmosphere, outgas carbon dioxide and takes up oxygen. Upon CO2-degassing, C-12 is

  5. Minimal stratifications for line arrangements and positive homogeneous presentations for fundamental groups

    CERN Document Server

    Yoshinaga, Masahiko

    2011-01-01

    The complement of a complex hyperplane arrangement is known to be homotopic to a minimal CW complex. There are several approaches to the minimality. In this paper, we restrict our attention to real two dimensional cases, and introduce the "dual" objects so called minimal stratifications. The strata are explicitly described as semialgebraic sets. The stratification induces a partition of the complement into a disjoint union of contractible spaces, which is minimal in the sense that the number of codimension $k$ pieces equals the $k$-th Betti number. We also discuss presentations for the fundamental group associated to the minimal stratification. In particular, we show that the fundamental groups of complements of a real arrangements have positive homogeneous presentations.

  6. Radiation-hard Beam Position Detector for Use in the Accelerator Dump Lines

    CERN Document Server

    Degtiarenko, Pavel; Popov, Vladimir

    2005-01-01

    Proper transport of the electron beam with over 0.5MW of power to the beam dump is a prerequisite for operations at Jefferson Lab. Operations has relied on imaging the beam on a beam viewer located at the entrance to the beam dump. The large beam size at the dump entrance, due to beam scattering in the experimental target, sometimes results in no observable image on the view-screen. Chemical vapor deposited silicon carbide (CVD) material with its large thermal conductivity and high melting point is well suited for surviving the thermal effects of beam exposure with this power density. We are exploring the CVD properties and how it can be used as a robust beam position monitor. Results of some beam tests with 0.5MW beams will be presented.

  7. Numerical modelling of ground vibration caused by elevated high-speed railway lines considering structure-soil-structure interaction

    DEFF Research Database (Denmark)

    Bucinskas, Paulius; Andersen, Lars Vabbersgaard; Persson, Kent

    2016-01-01

    Construction of high speed railway lines has been an increasing trend in recent years. Countries like Denmark and Sweden plan to expand and upgrade their railways to accommodate high-speed traffic. To benefit from the full potential of the reduced commuting times, these lines must pass through...... densely populated urban areas with the collateral effect of increased noise and vibrations levels. This paper aims to quantify the vibrations levels in the area surrounding an elevated railway line built as a multi-span bridge structure. The proposed model employs finite-element analysis to model...

  8. Simultaneous Determination of Averaged cross Sections for the Formation of Ground and Metastable State when Using Reactor Neutrons as Bombarding Particles the straight line method

    CERN Document Server

    Ribeiro Guevara, S

    2001-01-01

    determine, by this method, the production cross section for the ground state even in those cases where the assumption that one of the states has decayed completely, cannot be warranted.In cases where the ground state half life is much longer than that of the isomeric state, when employing direct methods, it is only possible to determine the sum cross section for the production of both states; therefore, if the metastable production cross section is known, then it is possible to determine, by subtraction, the ground state production cross section.When using the straight-line method, both cross sections can be determined separately.The main limitation of the method is the need to measure the g emission associated to the ground state decay at different time intervals.A parametric analysis of the equations associated to the method shows that under certain conditions it is not possible to apply the method, while under other conditions the method delivers optimum results.The method was applied to the study of four ...

  9. Position and orientation measurement adopting camera calibrated by projection geometry of Plücker matrices of three-dimensional lines

    Science.gov (United States)

    Xu, Guan; Zheng, Anqi; Li, Xiaotao; Su, Jian

    2017-03-01

    A position and orientation measurement method is investigated by adopting a camera calibrated by the projection geometry of the skew-symmetric Plücker matrices of 3D lines. The relationship between the Plücker matrices of the dual 3D lines and the 2D projective lines is provided in two vertical world coordinate planes. The transform matrix is generated from the projections of the 3D lines. The differences between the coordinates of the reprojective lines and the coordinates of extracted lines are employed to verify the calibration validity. Moreover, the differences between the standard movement distance of the target and the measurement distance are also presented to compare the calibration accuracy of the 3D line to 2D line method and the point-based method. Furthermore, we also explore the noise immunity of the two methods by adding Gaussian noises. Finally, an example to measure the position and orientation of a cart is performed as an application case of this method. The results are tabled for the reproduction by the readers. The results demonstrate that the line to line method contributes higher calibration accuracy and better noise immunity. The position and orientation measurement adopting the line to line method is valid for the future applications.

  10. Application of RAMAC Ground Probing Radar in Detection of Tunnel Lining%RAMAC地质雷达在隧道衬砌检测中的应用

    Institute of Scientific and Technical Information of China (English)

    牛连超; 高永涛; 吴顺川

    2011-01-01

    隧道衬砌属隐蔽工程施工.常规检查手段多以钻孔验证为主,带有随机性、有损性,且较盲目.地质雷达是利用高频脉冲电磁波探测地下介质分布的一种地球物理勘探方法.以北京-化稍营高速公路黄羊山隧道初衬检测为例,阐述地质雷达的原理和工作方式,并通过雷达图像的解析,得出钢拱架、初衬等的图像特点,为同类工程的研究提供参考.%Tunnel lining belongs to concealed work construction. Conventional detection measures are mainly-based on drilling for verification, with randomness, prejudice and blindness. Ground probing radar is a method of geophysical exploration to detect the distribution of underground medium using high frequency impulse electromagnetic wave. Taking the detection of Beijtng-Huashaoying Highway Huangyangshan tunnel lining for example, this paper describes the principle and working method of ground probing radar, and obtains the image characteristics of steel arch and initial lining through analysis of radar image, which provides a reference for research of (he similar engineering.

  11. 2D ground motion at a soft viscoelastic layer/hard substratum site in response to SH cylindrical seismic waves radiated by deep and shallow line sources

    CERN Document Server

    Wirgin, A; Wirgin, Armand

    2004-01-01

    We show, essentially by theoretical means, that for a site with the chosen simple geometry and mechanical properties (horizontal, homogeneous, soft viscoelastic layer of infinite lateral extent overlying, and in welded contact with, a homogeneous, hard elastic substratum of half-infinite radial extent, shear-horizontal motion): 1) coupling to Love modes is all the weaker the farther the seismic source (modeled as a line, assumed to lie in the substratum) is from the lower boundary of the soft layer, 2) for a line source close to the lower boundary of the soft layer, the ground response is characterized by possible beating phenomena, and is of significantly-longer duration than for excitation by cylindrical waves radiated by deep sources. Numerical applications of the theory show, for instance, that a line source, located 40m below the lower boundary of a 60m thick soft layer in a hypothetical Mexico City-like site, radiating a SH pulse of 4s duration, produces substantial ground motion during 200s, with marke...

  12. 小电流接地电网故障选线方法的研究%Research on Low Current Grounding Electric Network Fault Line Selection

    Institute of Scientific and Technical Information of China (English)

    何金朋; 聂赫; 刘颖

    2011-01-01

    The 35 kV or below power distribution network in China and small current grounding system single phase occurs single grounding,there is less difference between normal lines and fault line transient zero sequence current,which affects the precision of line selection.In view of this,one kind of digital filter is designed.The pure fault component of zero sequence current is extracted and the data is being analyzed,combined with substation automation generatrix insulate monitoring device and automation reclose device,the fault line is selected.The theoretical analysis and Matlab simulation experiment indicates the accuracy and reliability of line selection method has improved significantly.%针对我国35 kV及以下配电网小电流接地系统发生单相接地时,健全线路与故障线路暂态零序电流相差不大,影响了选线的精度等状况,设计了一种数字滤波器。它可提取零序电流的纯故障分量,对数据进行相关分析,结合变电站自动化母线绝缘监视装置以及自动重合闸装置,选出故障线路。通过理论分析和Matlab实验仿真表明,这种选线方法,其准确性、可靠性有明显提高。

  13. Dissecting the Power Sources of Low-Luminosity Emission-Line Galaxy Nuclei via Comparison of HST-STIS and Ground-Based Spectra

    CERN Document Server

    Constantin, Anca; Ho, Luis C; Barth, Aaron J; Filippenko, Alexei V; Castillo, Christopher A

    2015-01-01

    Using a sample of ~100 nearby line-emitting galaxy nuclei, we have built the currently definitive atlas of spectroscopic measurements of H_alpha and neighboring emission lines at subarcsecond scales. We employ these data in a quantitative comparison of the nebular emission in Hubble Space Telescope (HST) and ground-based apertures, which offer an order-of-magnitude difference in contrast, and provide new statistical constraints on the degree to which Transition Objects and low-ionization nuclear emission-line regions (LINERs) are powered by an accreting black hole at <10 pc. We show that while the small-aperture observations clearly resolve the nebular emission, the aperture dependence in the line ratios is generally weak, and this can be explained by gradients in the density of the line-emitting gas: the higher densities in the more nuclear regions potentially flatten the excitation gradients, suppressing the forbidden emission. The Transition Objects show a threefold increase in the incidence of broad H_...

  14. 输电线路杆塔接地电阻测量方法%Transmission Line Tower Grounding Resistance Measurement Method

    Institute of Scientific and Technical Information of China (English)

    范大鹏

    2015-01-01

    According to the transmission line tower grounding resistance equipment with the measured transmission lines are there any direct electrical connection,it can be divided into contact measurement and non-contact measurement method,has carried on the detailed introduction of its theory.Combining with the advantages and disadvantages of contact measurement and non-contact measurement method,the initial test contact measurement method may be used for the early stage of the transmission line tower grounding resistance of the layout of satisfy the lightning protection security requirements,such as late for transmission line tower guard,can be used in a non-contact method of measurement,can quickly find problems and in a timely manner.Regular testing of transmission line tower grounding resistance is also important to ensure the safe operation of the transmission line maintenance.%根据输电线路杆塔接地电阻设备与被测输电线路有无直接电气的连接,可将其划分为接触式测量方法和非接触式测量方法,对其原理进行了翔实介绍。结合接触式测量方法和非接触式测量方法的优缺点,初期的测试可以采用接触式测量方法进行前期输电线路杆塔的接地电阻的布置,使其满足防雷等安全要求,后期对输电线路杆塔进行巡防时,可以采用非接触式测量方法,能较快地发现问题并及时进行防护。定期检测输电线路杆塔的接地电阻也是维护输电线路安全运行的重要保证。

  15. TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines

    Science.gov (United States)

    Schwartz, J. L.; Jordan, R.; Liber, H.; Murnane, J. P.; Evans, H. H.

    2001-01-01

    Telomere shortening in telomerase-negative somatic cells leads to the activation of the TP53 protein and the elimination of potentially unstable cells. We examined the effect of TP53 gene expression on both telomere metabolism and chromosome stability in immortal, telomerase-positive cell lines. Telomere length, telomerase activity, and chromosome instability were measured in multiple clones isolated from three related human B-lymphoblast cell lines that vary in TP53 expression; TK6 cells express wild-type TP53, WTK1 cells overexpress a mutant form of TP53, and NH32 cells express no TP53 protein. Clonal variations in both telomere length and chromosome stability were observed, and shorter telomeres were associated with higher levels of chromosome instability. The shortest telomeres were found in WTK1- and NH32-derived cells, and these cells had 5- to 10-fold higher levels of chromosome instability. The primary marker of instability was the presence of dicentric chromosomes. Aneuploidy and other stable chromosome alterations were also found in clones showing high levels of dicentrics. Polyploidy was found only in WTK1-derived cells. Both telomere length and chromosome instability fluctuated in the different cell populations with time in culture, presumably as unstable cells and cells with short telomeres were eliminated from the growing population. Our results suggest that transient reductions in telomere lengths may be common in immortal cell lines and that these alterations in telomere metabolism can have a profound effect on chromosome stability. Copyright 2000 Wiley-Liss, Inc.

  16. Method Study Based on Ground Line Current Division Achieve Grounding Fault Location of DC Transmission Lines%基于地线分流实现直流输电线路接地故障区段定位的方法

    Institute of Scientific and Technical Information of China (English)

    王法; 曾东; 许金明; 张勇

    2012-01-01

    本文针对直流输电线路地线与杆塔非绝缘连接的特点,分析线路发生不同类型的接地故障时在各杆塔某一根地线上的故障电流分流特征。通过采集输电线路地线上故障电流的方向实现故障定位,从而为故障情况下不同的输电线路运维单位辅助决策服务。%In this article, according to DC transmission lines are non-isolated connected with tower, when different types of ground fault occur,we analyze the characteristics of fault current division through ground line of different towders. By collecting the direction of fault current in the ground line to achieve fault location. As a result, it supports decision service for the units of operation and maintenance of transmission lines when faults accur.

  17. Numerical modelling of ground vibration caused by elevated high-speed railway lines considering structure-soil-structure interaction

    DEFF Research Database (Denmark)

    Bucinskas, Paulius; Andersen, Lars Vabbersgaard; Persson, Kent

    2016-01-01

    the bridge structure, including a multi-degree-of-freedom vehicle model and accounting for the track unevenness via a nonlinear contact model. The foundations are implemented as rigid footings resting on the ground surface, while the soil is modelled utilizing Green’s function for a horizontally layered half......-space. The paper analyses the effects of structure-soil-structure interaction on the dynamic behaviour of the surrounding soil surface. The effects of different soil stratification and material properties as well as different train speeds are assessed. Finally, the drawbacks of simplifying the numerical model...

  18. Measured electric and magnetic fields from an unusual cloud-to-ground lightning flash containing two positive strokes followed by four negative strokes

    Science.gov (United States)

    Jerauld, J. E.; Uman, M. A.; Rakov, V. A.; Rambo, K. J.; Jordan, D. M.; Schnetzer, G. H.

    2009-10-01

    We present electric and magnetic fields measured at multiple stations between about 300 and 800 m of a cloud-to-ground "bipolar" lightning flash containing two initial positive strokes, separated in time by 53 ms and striking ground at two locations separated by about 800 m, followed by four negative strokes that traversed the same path as the second positive stroke. The leader electric field durations for the positive first, positive second, and negative third strokes were about 120 ms, 35 ms, and 1 ms, respectively. The first-stroke leader electric field changes measured at five stations ranged from about +16 to +35 kV/m, the second stroke +8 to +13 kV/m, and the third stroke -0.9 to -1.8 kV/m (atmospheric electricity sign convention). The microsecond-scale return stroke waveforms of the first and second (positive) strokes exhibited a similar "slow-front/fast-transition" to those observed for close negative first strokes. The peak rate-of-change of the positive first stroke electric field normalized to 100 km was about 20 V m-1μs-1, similar to the values observed for close negative first strokes. The positive second stroke was followed by a long continuing current of duration at least 400 ms, while the positive first stroke had a total current duration of only about 1 ms. All four negative strokes were followed by long continuing current, with durations ranging from about 70 ms to about 230 ms. The overall flash duration was about 1.5 s.

  19. Optimal Design of Transmission Lines Pole Tower Grounding Down Lead%输电线路铁塔接地引下线优化设计

    Institute of Scientific and Technical Information of China (English)

    代鑫波; 崔勇; 陈湘华

    2013-01-01

    针对传统接地引下线存在的易腐蚀和材料质地太硬的缺陷,提出将接地引下线的制作材料用镀锌钢绞线代替,同时制定了钢绞线接地引下线的安装方法,并通过热稳定计算确定了钢绞线截面积.实例应用结果表明,该优化设计方法安装简单、方便,成本小,同时在减少输电线路维护工作量、运行成本和延长接地引下线使用寿命等方面均具有很强的实用性.%Traditional grounding down lead has defects of corrosion easily and too hard material texture. This paper presents the grounding wire galvanized steel strand for instead of round steel and designs installation process. And then the steel wire cross-sectional area is determined by thermal stability calculation. Example results show that the optimized design scheme has advantages of simple installation and low cost. At the same time, it has practicability of reducing the transmission line maintenance workload, operation cost and prolonging the service life of grounding down lead.

  20. Hereditary position of relatives in direct ascending and collateral line, spouses and cohabitation partner: Comparative legal analysis

    Directory of Open Access Journals (Sweden)

    Vidić-Trninić Jelena

    2013-01-01

    Full Text Available This paper analyses hereditary position of ascendants and collateral relatives on one hand and a surviving spouse and cohabitation partner on the other hand, as intestate successors in the modern laws of Europe, particularly those belonging to the European civil law system, which also includes the Serbian legal system. The subject of the research is observed through the prism of comparative method which is necessary in order to obtain a comprehensive insight into the scope of application and the manner of usage of kinship in direct ascending and collateral line and marriage, that is, cohabitation, as material facts in formulating the rules of inheritance. This method further allows to recognize certain differences and, more importantly, similarities and common solutions and general legal principles that these laws are governed by in their legislative and theoretical approach regarding this issue. In this way we aim to answer the question to what extent the relationship between the kinship in the direct ascending and collateral line and marriage, in Serbian law, is synchronized with legal standards adopted in legal systems of the most other European countries; and whether there is a need in the local law, in particular in terms of adoption of the Civil Code of Serbia, for certain inheritance law reforms relating to regulation of this issue.

  1. Pertuzumab: a review of its use for first-line combination treatment of HER2-positive metastatic breast cancer.

    Science.gov (United States)

    McCormack, Paul L

    2013-09-01

    Pertuzumab (Perjeta®) is a humanized anti-HER2 monoclonal antibody that binds to the extracellular dimerization subdomain of the HER2 receptor and reduces HER2 intracellular signalling by preventing HER2 from forming heterodimers with other HER receptors. Inhibition of HER2 signalling results in a reduction of tumour cell proliferation, invasiveness and survival. Pertuzumab and trastuzumab bind to different sites on the HER2 receptor and have complementary antitumour activities; they act synergistically in inhibiting the growth of HER2-overexpressing breast cancer cell lines in vitro. The efficacy of intravenous pertuzumab (840 mg loading dose, then 420 mg every 3 weeks) in combination with trastuzumab plus docetaxel in the first-line treatment of HER2-positive metastatic breast cancer was demonstrated in the randomized, double-blind, placebo-controlled, multinational, phase III CLEOPATRA trial. Pertuzumab in combination with trastuzumab and docetaxel significantly increased independently assessed median progression-free survival (primary endpoint), objective response rate and overall survival compared with placebo in combination with trastuzumab and docetaxel. Pertuzumab had an acceptable tolerability profile when added to trastuzumab and docetaxel in the pivotal CLEOPATRA trial. Thus, pertuzumab is a valuable addition to the growing list of anti-HER2 targeted therapies for breast cancer.

  2. Expression of TLR4/iNOS pathway molecules in high-risk HPV-positive cervical cancer tissue and cell lines and its significance

    Institute of Scientific and Technical Information of China (English)

    Ding Wang; Zhi-Ying Li; Jiao Lu

    2016-01-01

    Objective:To study the expression of TLR4/iNOS pathway molecules in high-risk HPV-positive cervical cancer tissue and cell lines and its significance.Methods: 35 cases of patients with high-risk HPV-positive cervical cancer and 35 cases of healthy subjects receiving cervical biopsy were enrolled for study, and mRNA contents of TLRs and NOS in cervical tissue were analyzed. CaSki cell lines (HPV16-positive), Hela cell lines (HPV18-positive) and C33a cell lines (HPV-negative) were cultured, siRNA was transfected and contents of TLR4, NF-kB, iNOS and NO were detected.Results:mRNA contents of TLR4 and iNOS in high-risk HPV-positive cervical cancer tissue were significantly higher than those in normal cervical biopsy tissue, and comparison of mRNA contents of TLR3, TLR7, TLR8, TLR9, eNOS and nNOS with normal cervical biopsy tissue showed no significant differences; mRNA contents of TLR4, NF-kB and iNOS as well as NO levels in CaSki cell lines and Hela cell lines were higher than those in C33a cell lines; after transfection of TLR4 siRNA, mRNA contents of NF-kB and iNOS as well as NO levels in CaSki cell lines and Hela cell lines were lower than those transfected with negative control siRNA.Conclusions: Expression of TLR4/iNOS pathway molecules in high-risk HPV-positive cervical cancer tissue and cell lines increases, and TLR4 can increase iNOS expression and NO generation through NF-kB, thus participating in pathological process of cervical cancer caused by high-risk HPV.

  3. Positive correlation between the cyclotron line energy and luminosity in sub-critical X-ray pulsars: Doppler effect in the accretion channel

    Science.gov (United States)

    Mushtukov, Alexander A.; Tsygankov, Sergey S.; Serber, Alexander V.; Suleimanov, Valery F.; Poutanen, Juri

    2015-12-01

    Cyclotron resonance scattering features observed in the spectra of some X-ray pulsars show significant changes of the line centroid energy with the pulsar luminosity. Whereas for bright sources above the so-called critical luminosity, these variations are established to be connected with the appearance of the high-accretion column above the neutron star surface, at low, sub-critical luminosities the nature of the variations (but with the opposite sign) has not been discussed widely. We argue here that the cyclotron line is formed when the radiation from a hotspot propagates through the plasma falling with a mildly relativistic velocity on to the neutron star surface. The position of the cyclotron resonance is determined by the Doppler effect. The change of the cyclotron line position in the spectrum with luminosity is caused by variations of the velocity profile in the line-forming region affected by the radiation pressure force. The presented model has several characteristic features: (i) the line centroid energy is positively correlated with the luminosity; (ii) the line width is positively correlated with the luminosity as well; (iii) the position and the width of the cyclotron absorption line are variable over the pulse phase; (iv) the line has a more complicated shape than widely used Lorentzian or Gaussian profiles; (v) the phase-resolved cyclotron line centroid energy and the width are negatively and positively correlated with the pulse intensity, respectively. The predictions of the proposed theory are compared with the variations of the cyclotron line parameters in the X-ray pulsar GX 304-1 over a wide range of sub-critical luminosities as seen by the INTEGRAL observatory.

  4. Ground state energy and wave function of an off-centre donor in spherical core/shell nanostructures: Dielectric mismatch and impurity position effects

    Energy Technology Data Exchange (ETDEWEB)

    Ibral, Asmaa [Equipe d’Optique et Electronique du Solide, Département de Physique, Faculté des Sciences, Université Chouaïb Doukkali, B.P. 20 El Jadida Principale, El Jadida 24000 (Morocco); Laboratoire d’Instrumentation, Mesure et Contrôle, Département de Physique, Université Chouaïb Doukkali, B.P. 20 El Jadida Principale, El Jadida (Morocco); Zouitine, Asmae [Département de Physique, Ecole Nationale Supérieure d’Enseignement Technique, Université Mohammed V Souissi, B.P. 6207 Rabat-Instituts, Rabat (Morocco); Assaid, El Mahdi, E-mail: eassaid@yahoo.fr [Equipe d’Optique et Electronique du Solide, Département de Physique, Faculté des Sciences, Université Chouaïb Doukkali, B.P. 20 El Jadida Principale, El Jadida 24000 (Morocco); Laboratoire d’Instrumentation, Mesure et Contrôle, Département de Physique, Université Chouaïb Doukkali, B.P. 20 El Jadida Principale, El Jadida (Morocco); Feddi, El Mustapha [Département de Physique, Ecole Nationale Supérieure d’Enseignement Technique, Université Mohammed V Souissi, B.P. 6207 Rabat-Instituts, Rabat (Morocco); and others

    2014-09-15

    Ground state energy and wave function of a hydrogen-like off-centre donor impurity, confined anywhere in a ZnS/CdSe spherical core/shell nanostructure are determined in the framework of the envelope function approximation. Conduction band-edge alignment between core and shell of nanostructure is described by a finite height barrier. Dielectric constant mismatch at the surface where core and shell materials meet is taken into account. Electron effective mass mismatch at the inner surface between core and shell is considered. A trial wave function where coulomb attraction between electron and off-centre ionized donor is used to calculate ground state energy via the Ritz variational principle. The numerical approach developed enables access to the dependence of binding energy, coulomb correlation parameter, spatial extension and radial probability density with respect to core radius, shell radius and impurity position inside ZnS/CdSe core/shell nanostructure.

  5. Special requisites for ground switch operation of parallel circuits of strongly connected transmission lines; Requisitos especiais de manobra para chaves de terra de circuitos paralelos de linhas de transmissao fortemente acoplados

    Energy Technology Data Exchange (ETDEWEB)

    Amon Filho, J.; Kastrup Filho, O.; Franca, W.J. [FURNAS, Rio de Janeiro, RJ (Brazil)

    1993-12-31

    This work aims to present results of a qualitative and quantitative analysis of the problem concerning the ground switch turn off operation of transmission lines parallel circuits involving computer simulations and field tests, being such tests compared to standards and constant criteria of the technical specifications of such ground switches. The so far achieved conclusions indicate that the arc resistors installed in the ground switches have been satisfactory solving the problem of the interruption of induced currents by those ground switches. 7 refs., 2 figs., 3 tabs.

  6. Hubungan tweed triangle dan posisi bibir terhadap garis estetik (Relationship between tweed triangle and the lips position to esthetic line

    Directory of Open Access Journals (Sweden)

    Intan Oktaviona

    2014-12-01

    Full Text Available Background: The aimed of almost all of patient came for orthodontics treatment, were to recover face esthetic or their profile. The facial profile not only determined by the hard tissue, but will also be influenced by the soft tissue such as nose, lip, and chin. Tweed has done face analysis with cephalometric by using three angles which are FMA, FMIA, and IMPA. There are many facial profile analysis that usually use in lateral cephalometric one of them is Ricketts analysis that draw the line from pogonion to the tip of nose. The biggest tribe in Indonesia is Javanese, the Javanese have a specific characteristic. Javanese people do not have a long nose and the chin not really uppermost, thick lip, convex profile and female’s profile more convex than male. Purpose: The study was aimed to examine the relation between Tweed triangle, upper lip and lower lip to esthetic line according to Ricketts. Methods: The facial profile pictures of subjects which were taken base on sample criteria changed into silhouette black and white. The photo selected by orthodontist and lay persons. Then the lateral cephalometric radiograph was taken and measured the angle of Tweed triangle and the lip position to esthetic line. Results: The FMA were 28.830, FMIA were 56.740 and IMPA were 94.430. The upper lip distance among males were closer to the esthetic line than female. The lower lip of males located in front of esthetic line and female lower lip located rare of esthetic line. Conclusion: There was corelation between FMA and FMIA with lower lip. There was no corelation between IMPA towards upper lip and also lower lip.Latar belakang: Tujuan dari hampir seluruh pasien yang datang untuk perawatan ortodonti adalah untuk memperbaiki estetis wajah atau profilnya. Profil fasial tidak hanya ditentukan oleh jaringan keras, akan tetapi juga akan sangat dipengaruhi oleh jaringan lunak hidung, bibir, dan dagu. Tweed melakukan analisis wajah pada sefalometri menggunakan 3

  7. Rhinoplasty Setsquare Device: A Novel Instrument to Verify Columellar and Nasal Dorsal Position at the Midsagittal Line

    Directory of Open Access Journals (Sweden)

    Aret Çerçi Özkan, MD

    2017-07-01

    Full Text Available Summary:. Even a mild degree of postoperative deviation of the nasal dorsum and/or columella from the midsagittal plane could be enough to displease a patient. Postoperative judgment of the nasal dorsum and the columellar positioning on the midsagittal plane is somewhat of a subjective decision determined by the surgeons’ naked eye. Most innovations tend to evolve from necessities. The risk and reality of misjudging the positioning for both the nasal dorsum and/or the columella led me to develop a device for the objective measurement of the midsagittal axis of the nose. I have called it the rhinoplasty setsquare device. This device is made from 316 quality stainless chrome. It is completely sterilizable. It consists of 4 main parts. During the finishing touches of the operation, the correct placement of the rhinoplasty setsquare device will provide the surgeon with an objective decision that will help make the positioning of the nasal dorsum and the columella more precise. When I conducted my research on literature and device catalogs for possible devices designed for measurement in rhinoplasty operations, I ran into devices such as the Castroviejo caliper, calibrated lateral crus stabilizer, Joseph measuring rod, and Thorpe Marchac caliper. All of them are unique in their function and design. However, as far as I could see, there is no device similar in form and function to my rhinoplasty setsquare device. I have been using this device for 8 months for all my rhinoplasty patients. I am more confident now in my postoperative results due to its objective measurement of the midsagittal line.

  8. Rhinoplasty Setsquare Device: A Novel Instrument to Verify Columellar and Nasal Dorsal Position at the Midsagittal Line.

    Science.gov (United States)

    Çerçi Özkan, Aret

    2017-07-01

    Even a mild degree of postoperative deviation of the nasal dorsum and/or columella from the midsagittal plane could be enough to displease a patient. Postoperative judgment of the nasal dorsum and the columellar positioning on the midsagittal plane is somewhat of a subjective decision determined by the surgeons' naked eye. Most innovations tend to evolve from necessities. The risk and reality of misjudging the positioning for both the nasal dorsum and/or the columella led me to develop a device for the objective measurement of the midsagittal axis of the nose. I have called it the rhinoplasty setsquare device. This device is made from 316 quality stainless chrome. It is completely sterilizable. It consists of 4 main parts. During the finishing touches of the operation, the correct placement of the rhinoplasty setsquare device will provide the surgeon with an objective decision that will help make the positioning of the nasal dorsum and the columella more precise. When I conducted my research on literature and device catalogs for possible devices designed for measurement in rhinoplasty operations, I ran into devices such as the Castroviejo caliper, calibrated lateral crus stabilizer, Joseph measuring rod, and Thorpe Marchac caliper. All of them are unique in their function and design. However, as far as I could see, there is no device similar in form and function to my rhinoplasty setsquare device. I have been using this device for 8 months for all my rhinoplasty patients. I am more confident now in my postoperative results due to its objective measurement of the midsagittal line.

  9. Positive correlation between the cyclotron line energy and luminosity in sub-critical X-ray pulsars: Doppler effect in the accretion channel

    CERN Document Server

    Mushtukov, Alexander A; Serber, Alexander V; Suleimanov, Valery F; Poutanen, Juri

    2015-01-01

    Cyclotron resonance scattering features observed in the spectra of some X-ray pulsars show significant changes of the line centroid energy with the pulsar luminosity. Whereas for bright sources above the so called critical luminosity these variations are established to be connected with the appearance of the high accretion column above the neutron star surface, at low, sub-critical luminosities the nature of the variations (but with the opposite sign) has not been discussed widely. We argue here that the cyclotron line is formed when the radiation from a hotspot propagates through the plasma falling with a mildly relativistic velocity onto the neutron star surface. The position of the cyclotron resonance is determined by the Doppler effect. The change of the cyclotron line position in the spectrum with luminosity is caused by variations of the velocity profile in the line-forming region affected by the radiation pressure force. The presented model has several characteristic features: (i) the line centroid ene...

  10. A data acquisition system for two-dimensional position sensitive micropattern gas detectors with delay-line readout

    Energy Technology Data Exchange (ETDEWEB)

    Hanu, A.R., E-mail: hanua@mcmaster.ca [Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1 (Canada); NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Prestwich, W.V.; Byun, S.H. [Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada L8S 4K1 (Canada)

    2015-04-21

    We present a data acquisition (DAQ) system for two-dimensional position sensitive micropattern gas detectors using the delay-line method for readout. The DAQ system consists of a field programmable gate array (FPGA) as the main data processor and our time-to-digital (TDC) mezzanine card for making time measurements. We developed the TDC mezzanine card around the Acam TDC-GPX ASIC and it features four independent stop channels referenced to a common start, a typical timing resolution of ~81 ps, and a 17-bit measurement range, and is compliant with the VITA 57.1 standard. For our DAQ system, we have chosen the Xilinx SP601 development kit which features a single Spartan 6 FPGA, 128 MB of DDR2 memory, and a serial USB interface for communication. Output images consist of 1024×1024 square pixels, where each pixel has a 32-bit depth and corresponds to a time difference of 162 ps relative to its neighbours. When configured for a 250 ns acquisition window, the DAQ can resolve periodic event rates up to 1.8×10{sup 6} Hz without any loses and will report a maximum event rate of 6.11×10{sup 5} Hz for events whose arrival times follow Poisson statistics. The integral and differential non-linearities have also been measured and are better than 0.1% and 1.5%, respectively. Unlike commercial units, our DAQ system implements the delay-line image reconstruction algorithm entirely in hardware and is particularly attractive for its modularity, low cost, ease of integration, excellent linearity, and high throughput rate.

  11. Facies and depositional architecture according to a jet efflux model of a late Paleozoic tidewater grounding-line system from the Itararé Group (Paraná Basin), southern Brazil

    Science.gov (United States)

    Aquino, Carolina Danielski; Buso, Victoria Valdez; Faccini, Ubiratan Ferrucio; Milana, Juan Pablo; Paim, Paulo Sergio Gomes

    2016-04-01

    -laden nature of the flows. At the transitional zone, a hydraulic jump produces a rapid shift of conglomeratic to sandy facies with associated scour features. Towards the distal zones, the jet detaches to originate a vertical turbulent jet characterized by more diluted flows. Discussion of fan facies and architecture within a framework of jet-efflux dynamics provides an improved understanding of grounding-line fans systems that produce coarse-grained strata commonly enclosed by fine-grained rocks. The results have clear implication in terms of prediction of facies tract and geometry of oil and gas reservoirs deposited under similar conditions. And also can be useful to identifying the position of a glacial terminus through time.

  12. Doxycycline inhibits proliferation and induces apoptosis of both human papillomavirus positive and negative cervical cancer cell lines.

    Science.gov (United States)

    Zhao, Yan; Wang, Xinyu; Li, Lei; Li, Changzhong

    2016-05-01

    The clinical management of cervical cancer remains a challenge and the development of new treatment strategies merits attention. However, the discovery and development of novel compounds can be a long and labourious process. Drug repositioning may circumvent this process and facilitate the rapid translation of hypothesis-driven science into the clinics. In this work, we show that a FDA-approved antibiotic, doxycycline, effectively targets human papillomavirus (HPV) positive and negative cervical cancer cells in vitro and in vivo. Doxycycline significantly inhibits proliferation of a panel of cervical cancer cell lines. It also induces apoptosis of cervical cancer cells in a time- and dose-dependent manner. In addition, the apoptosis induced by doxycycline is through caspase-dependent pathway. Mechanism studies demonstrate that doxycycline affects oxygen consumption rate, glycolysis, and reduces ATP levels in cervical cancer cells. In HeLa xenograft mouse model, doxycycline significantly inhibits growth of tumour. Our in vitro and in vivo data clearly demonstrate the inhibitory effects of doxycycline on the growth and survival of cervical cancer cells. Our work provides the evidence that doxycycline can be repurposed for the treatment of cervical cancer and targeting energy metabolism may represent a potential therapeutic strategy for cervical cancer.

  13. Positive deviance control-case life history: a method to develop grounded hypotheses about successful long-term avoidance of infection

    Directory of Open Access Journals (Sweden)

    Sandoval Milagros

    2008-03-01

    Full Text Available Abstract Background Prevalence rates for long-term injection drug users in some localities surpass 60% for HIV and 80% for HCV. We describe methods for developing grounded hypotheses about how some injectors avoid infection with either virus. Methods Subjects: 25 drug injectors who have injected drugs 8 – 15 years in New York City. 17 remain without antibody to either HIV or HCV; 3 are double-positives; and 5 are positive for HCV but not HIV. "Staying Safe" methodology compares serostatus groups using detailed biographical timelines and narratives; and information about how subjects maintain access to physical resources and social support; their strategies and tactics to remain safe; how they handle problems of addiction and demands by drug dealers and other drug users; and how their behaviors and strategies do or do not become socially-embedded practices. Grounded theory and life-history analysis techniques compare and contrast doubly-uninfected with those infected with both viruses or only with HCV. Results Themes and initial hypotheses emerging from analyses included two master hypotheses that, if confirmed, should help shape preventive interventions: 1 Staying uninfected is not simply a question of social structure or social position. It involves agency by drug injectors, including sustained hard work and adaptation to changing circumstances. 2 Multiple intentionalities contribute to remaining uninfected. These conscious goals include balancing one's need for drugs and one's income; developing ways to avoid drug withdrawal sickness; avoiding situations where other drug users importune you to share drugs; and avoiding HIV (and perhaps HCV infection. Thus, focusing on a single goal in prevention might be sub-optimal. Other hypotheses specify mechanisms of enacting these intentionalities. One example is finding ways to avoid extreme social ostracism. Conclusion We have identified strategies and tactics that some doubly-uninfected IDUs have

  14. Stereoscopic ground-based determination of the cloud base height: theory of camera position calibration with account for lens distortion

    Science.gov (United States)

    Chulichkov, Alexey I.; Postylyakov, Oleg V.

    2016-05-01

    For the reconstruction of some geometrical characteristics of clouds a method was developed based on taking pictures of the sky by a pair of digital photo cameras and subsequent processing of the obtained sequence of stereo frames to obtain the height of the cloud base. Since the directions of the optical axes of the stereo cameras are not exactly known, a procedure of adjusting of obtained frames was developed which use photographs of the night starry sky. In the second step, the method of the morphological analysis of images is used to determine the relative shift of the coordinates of some fragment of cloud. The shift is used to estimate the searched cloud base height. The proposed method can be used for automatic processing of stereo data and getting the cloud base height. The earlier paper described a mathematical model of stereophotography measurement, poses and solves the problem of adjusting of optical axes of the cameras in paraxial (first-order geometric optics) approximation and was applied for the central part of the sky frames. This paper describes the model of experiment which takes into account lens distortion in Seidel approximation (depending on the third order of the distance from optical axis). We developed procedure of simultaneous camera position calibration and estimation of parameters of lens distortion in Seidel approximation.

  15. Correction of patient positioning errors based on in-line cone beam CTs: clinical implementation and first experiences

    Directory of Open Access Journals (Sweden)

    Häring Peter

    2006-05-01

    Full Text Available Abstract Background The purpose of the study was the clinical implementation of a kV cone beam CT (CBCT for setup correction in radiotherapy. Patients and methods For evaluation of the setup correction workflow, six tumor patients (lung cancer, sacral chordoma, head-and-neck and paraspinal tumor, and two prostate cancer patients were selected. All patients were treated with fractionated stereotactic radiotherapy, five of them with intensity modulated radiotherapy (IMRT. For patient fixation, a scotch cast body frame or a vacuum pillow, each in combination with a scotch cast head mask, were used. The imaging equipment, consisting of an x-ray tube and a flat panel imager (FPI, was attached to a Siemens linear accelerator according to the in-line approach, i.e. with the imaging beam mounted opposite to the treatment beam sharing the same isocenter. For dose delivery, the treatment beam has to traverse the FPI which is mounted in the accessory tray below the multi-leaf collimator. For each patient, a predefined number of imaging projections over a range of at least 200 degrees were acquired. The fast reconstruction of the 3D-CBCT dataset was done with an implementation of the Feldkamp-David-Kress (FDK algorithm. For the registration of the treatment planning CT with the acquired CBCT, an automatic mutual information matcher and manual matching was used. Results and discussion Bony landmarks were easily detected and the table shifts for correction of setup deviations could be automatically calculated in all cases. The image quality was sufficient for a visual comparison of the desired target point with the isocenter visible on the CBCT. Soft tissue contrast was problematic for the prostate of an obese patient, but good in the lung tumor case. The detected maximum setup deviation was 3 mm for patients fixated with the body frame, and 6 mm for patients positioned in the vacuum pillow. Using an action level of 2 mm translational error, a target point

  16. Retention in care among HIV-positive patients initiating second-line antiretroviral therapy: a retrospective study from an Ethiopian public hospital clinic

    Directory of Open Access Journals (Sweden)

    Sten Wilhelmson

    2016-01-01

    Full Text Available Background: Access to second-line antiretroviral therapy (ART for HIV-positive patients remains limited in sub-Saharan Africa. Furthermore, outcomes of second-line ART may be compromised by mortality and loss to follow-up (LTFU. Objective: To determine retention in care among patients receiving second-line ART in a public hospital in Ethiopia, and to investigate factors associated with LTFU among adults and adolescents. Design: HIV-positive persons with documented change of first-line ART to a second-line regimen were retrospectively identified from hospital registers, and data were collected at the time of treatment change and subsequent clinic visits. Baseline variables for adults and adolescents were analyzed using multivariate Cox proportional hazards models comparing subjects remaining in care and those LTFU (defined as a missed appointment of ≥90 days. Results: A total of 383 persons had started second-line ART (330 adults/adolescents; 53 children and were followed for a median of 22.2 months (the total follow-up time was 906 person years. At the end of study follow-up, 80.5% of patients remained in care (adults and adolescents 79.8%; children 85.7%. In multivariate analysis, LTFU among adults and adolescents was associated with a baseline CD4 cell count <100 cells/mm3 and a first-line regimen failure that was not confirmed by HIV RNA testing. Conclusions: Although retention in care during second-line ART in this cohort was satisfactory, and similar to that reported from first-line ART programs in Ethiopia, our findings suggest the benefit of earlier recognition of patients with first-line ART failure and confirmation of suspected treatment failure by viral load testing.

  17. Retrievals of ethane from ground-based high-resolution FTIR solar observations with updated line parameters: determination of the optimum strategy for the Jungfraujoch station.

    Science.gov (United States)

    Bader, W.; Perrin, A.; Jacquemart, D.; Sudo, K.; Yashiro, H.; Gauss, M.; Demoulin, P.; Servais, C.; Mahieu, E.

    2012-04-01

    Ethane (C2H6) is the most abundant Non-Methane HydroCarbon (NMHC) in the Earth's atmosphere, with a lifetime of approximately 2 months. C2H6 has both anthropogenic and natural emission sources such as biomass burning, natural gas loss and biofuel consumption. Oxidation by the hydroxyl radical is by far the major C2H6 sink as the seasonally changing OH concentration controls the strong modulation of the ethane abundance throughout the year. Ethane lowers Cl atom concentrations in the lower stratosphere and is a major source of peroxyacetyl nitrate (PAN) and carbon monoxide (by reaction with OH). Involved in the formation of tropospheric ozone and in the destruction of atmospheric methane through changes in OH, C2H6 is a non-direct greenhouse gas with a net-global warming potential (100-yr horizon) of 5.5. The retrieval of ethane from ground-based infrared (IR) spectra is challenging. Indeed, the fitting of the ethane features is complicated by numerous interferences by strong water vapor, ozone and methane absorptions. Moreover, ethane has a complicated spectrum with many interacting vibrational modes and the current state of ethane parameters in HITRAN (e.g. : Rothman et al., 2009, see http://www.hitran.com) was rather unsatisfactory in the 3 μm region. In fact, PQ branches outside the 2973-3001 cm-1 range are not included in HITRAN, and most P and R structures are missing. New ethane absorption cross sections recorded at the Molecular Spectroscopy Facility of the Rutherford Appleton Laboratory (Harrison et al., 2010) are used in our retrievals. They were calibrated in intensity by using reference low-resolution spectra from the Pacific Northwest National Laboratory (PNNL) IR database. Pseudoline parameters fitted to these ethane spectra have been combined with HITRAN 2004 line parameters (including all the 2006 updates) for all other species encompassed in the selected microwindows. Also, the improvement brought by the update of the line positions and intensities

  18. Polarized hard X-ray photoemission system with micro-positioning technique for probing ground-state symmetry of strongly correlated materials.

    Science.gov (United States)

    Fujiwara, Hidenori; Naimen, Sho; Higashiya, Atsushi; Kanai, Yuina; Yomosa, Hiroshi; Yamagami, Kohei; Kiss, Takayuki; Kadono, Toshiharu; Imada, Shin; Yamasaki, Atsushi; Takase, Kouichi; Otsuka, Shintaro; Shimizu, Tomohiro; Shingubara, Shoso; Suga, Shigemasa; Yabashi, Makina; Tamasaku, Kenji; Ishikawa, Tetsuya; Sekiyama, Akira

    2016-05-01

    An angle-resolved linearly polarized hard X-ray photoemission spectroscopy (HAXPES) system has been developed to study the ground-state symmetry of strongly correlated materials. The linear polarization of the incoming X-ray beam is switched by a transmission-type phase retarder composed of two diamond (100) crystals. The best value of the degree of linear polarization was found to be -0.96, containing a vertical polarization component of 98%. A newly developed low-temperature two-axis manipulator enables easy polar and azimuthal rotations to select the detection direction of photoelectrons. The lowest temperature achieved was 9 K, offering the chance to access the ground state even for strongly correlated electron systems in cubic symmetry. A co-axial sample monitoring system with long-working-distance microscope enables the same region on the sample surface to be measured before and after rotation. Combining this sample monitoring system with a micro-focused X-ray beam by means of an ellipsoidal Kirkpatrick-Baez mirror (25 µm × 25 µm FWHM), polarized valence-band HAXPES has been performed on NiO for voltage application as resistive random access memory to demonstrate the micro-positioning technique and polarization switching.

  19. Self-healing of single-phase grounding fault for power distribution lines%配电线路单相接地故障自愈方案

    Institute of Scientific and Technical Information of China (English)

    施慎行; 董新洲; 吴家华; 沈冬

    2012-01-01

    A self-healing scheme is presented for the single-phase grounding fault of distribution lines,which consists of four parts:fault detection, faulty feeder selection, faulty section identification and faulty feeder isolation. The fault detection is based on the open-delta-side voltages of PT. A single-phase grounding fault is identified when the measured voltage is greater than the setting value. The faulty feeder selection is based on the current traveling waves. The feeder with different traveling wave polarity is selected as the faulty one. The faulty section identification is based on the synthesized results of faulty feeder selection. After the faulty feeder is selected,close the interconnection switch at the load side first,then open its incoming switch and isolate the power source side of faulty. Simulative results show that the scheme realizes the automatic quick isolation of single-phase grounding fault without power loss of load.%针对配电线路的单相接地故障,提出了故障自愈方案.方案包括单相接地故障检测、故障选线、故障区段识别和接地线路隔离4个部分.故障检测基于母线上的电压互感器开口三角侧电压,当测量电压大于整定值时,判断系统中发生了单相接地故障;故障选线基于线路上的电流行波,极性与众不同的电流行波所在线路为接地线路;故障区段识别基于故障选线的综合结果;选出故障母线后,先闭合接地线路负荷侧的联络开关,再打开接地线路负荷侧进线开关,最后隔离接地线路电源侧.仿真结果表明,所提自愈方案可实现单相接地故障自动快速隔离,故障隔离过程中负荷不失电.

  20. Existence of Positive Solutions for Systems of Nonlinear Second-Order Differential Equations on the Half Line in a Banach Space

    Institute of Scientific and Technical Information of China (English)

    Xing Qiu ZHANG

    2011-01-01

    In this paper,the cone theory and M(o)nch fixed point theorem combined with the monotone iterative technique are used to investigate the positive solutions for a class of systems of nonlinear singular differential equations with multi-point boundary value conditions on the half line in a Banach space.The conditions for the existence of positive solutions are formulated.In addition,an explicit iterative approximation of the solution is also derived.

  1. Measurements of Line Positions and Intensities of 14NH_3 in the 1.5 μm Region

    Science.gov (United States)

    Sung, Keeyoon; Brown, Linda R.; Huang, Xinchuan; Schwenke, David W.; Lee, Timothy J.

    2011-06-01

    In the atmosphere of outer planets, low mass brown dwarfs, and possibly extrasolar planets, ammonia (NH_3) is one of the major opacity sources particularly in the 1.5 μm region (the H-band). However, the spectroscopic information of NH_3 in the region is completely missing in the HITRAN database. NH_3 has four infrared active fundamental modes, with the well-known inversion doubling for {ν_2} band, in addition to the usual vibrational degeneracies. Its strong bands, {ν_1}, {ν_3} and 2{ν_4}, dominate the spectrum at 3 μm, while their corresponding overtone and combination bands (e.g., 2{ν_1}, 2{ν_3}, {ν_1}+{ν_3}, {ν_1}+2{ν_4} and {ν_3}+2{ν_4}) are prominent in the 1.5 μm region. As part of an effort to provide a complete set of NH_3 spectroscopic information in the 1.5 μm region, we are analyzing the laboratory spectra recorded at various temperatures (200 - 299 K) with the McMath-Pierce Fourier transform spectrometer (FTS) on Kitt Peak Observatory in Arizona. Line positions and strengths have been measured from the laboratory spectra, from which lower state energies and quantum assignments are being determined by adopting intensity ratios at two different temperatures and combination differnces. A theoretical IR linelist built upon the recent HSL-2 potential energy surface (nonadiabatic corrections included) is complementarily used for the quantum assignments. Preliminary results are presented for {ν_1}+{ν_3}, 2{ν_3}, {ν_1}+2{ν_4} and {ν_3}+{2ν_4} bands and compared with those from early work available. X. Huang, D.W. Schwenke, and T.J. Lee J. Chem. Phys. 134, (2011) 044320/044321 The research described in this paper was performed at the Jet Propulsion Laboratory, California Institute of Technology and the Ames Research Center under contracts with National Aeronautics and Space Administration.

  2. 500 kV 直流地线融冰方法%Research on the Implementation of DC Ground Wire Ice-melting for 500 kV Niu-Cong Transmission Line

    Institute of Scientific and Technical Information of China (English)

    张锐; 曹双全

    2014-01-01

    介绍输电线路抗冰改造、加装融冰装置及增加覆冰在线监测装置等措施,在线路覆冰初期,启动融冰装置对覆冰导线、地线进行融冰,有效地保护了输电线路的安全。%took many measures such as transmission lines resisting ice, increasing melting ice device and measure of the icing on-line monitoring device, At the beginning of transmission lines iced, starting melting ice device to melt ice for iced conductor lines and grounding lines, taking these measures can protect the safety of the transmission lines effectively.

  3. Research on the Implementation of DC Ground Wire Ice-melting for 500 kV Niu-Cong Transmission Line%500kV直流地线融冰方法

    Institute of Scientific and Technical Information of China (English)

    张锐; 曹双全

    2014-01-01

    介绍输电线路抗冰改造、加装融冰装置及增加覆冰在线监测装置等措施,在线路覆冰初期,启动融冰装置对覆冰导线、地线进行融冰,有效地保护了输电线路的安全。%took many measures such as transmission lines resisting ice, increasing melting ice device and measure of the icing on-line monitoring device, At the beginning of transmission lines iced, starting melting ice device to melt ice for iced conductor lines and grounding lines, taking these measures can protect the safety of the transmission lines effectively.

  4. Sloped Ground Lines - USACE IENC

    Data.gov (United States)

    Department of Homeland Security — These inland electronic Navigational charts (IENCs) were developed from available data used in maintenance of Navigation channels. Users of these IENCs should be...

  5. The Expectation of $X^1$ as a Function of $\\mathbb{E}(X)$ for an Exponential Family on the Positive Line

    OpenAIRE

    Letac, Gerard; Seshadri, Vanamamalai

    1989-01-01

    If the distribution of $X$ belongs to a natural exponential family on the positive real line, this note studies the expectation of the reciprocal of $X$ as a function of the expectation $m$ of $X$ and characterizes the cases where this function is an affine function of $m^{-1}$ as gamma, inverse-Gaussian, Ressel or Abel families.

  6. Improved instrumental line shape monitoring for the ground-based, high-resolution FTIR spectrometers of the Network for the Detection of Atmospheric Composition Change

    Directory of Open Access Journals (Sweden)

    F. Hase

    2012-03-01

    Full Text Available We propose an improved monitoring scheme for the instrumental line shape (ILS of high-resolution, ground-based FTIR (Fourier Transform InfraRed spectrometers used for chemical monitoring of the atmosphere by the Network for Detection of Atmospheric Composition Change (NDACC. Good ILS knowledge is required for the analysis of the recorded mid-infrared spectra. The new method applies a sequence of measurements using different gas cells instead of a single calibration cell. Three cells are used: cell C1 is a refillable cell offering 200 mm path length and equipped with a pressure gauge (filled with 100 Pa N2O, cells C2 and C3 are sealed cells offering 75 mm path length. C2 is filled with 5 Pa of pure N2O. Cell C3 is filled with 16 Pa N2O in 200 hPa technical air, so provides pressure-broadened N2O lines. We demonstrate that an ILS retrieval using C1 improves significantly the sensitivity of the ILS retrieval over the current calibration cells used in the network, because this cell provides narrow fully saturated N2O lines. The N2O columns derived from C2 and C3 allow the performance of a highly valuable closure experiment: adopting the ILS retrieved from C1, the N2O columns of C2 and C3 are derived. Because N2O is an inert gas, both columns should be constant on long timescales. Apparent changes in the columns would immediately attract attention and indicate either inconsistent ILS results or instrumental problems of other origin. Two different cells are applied for the closure experiment, because the NDACC spectrometers observe both stratospheric and tropospheric gases: C2 mimics signatures of stratospheric gases, whereas C3 mimics signatures of tropospheric gases.

  7. Aircraft Ground Operation, Servicing, Fluid Lines and Fittings, Mechanics Privileges and Limitations, and Maintenance Publications, Forms and Records (Course Outline), Aviation Mechanics 1 (Power and Frame): 9073.02.

    Science.gov (United States)

    Dade County Public Schools, Miami, FL.

    The course outline consists of five instructional blocks of several units each: (1) Aircraft Ground Operation and Servicing; (2) Fluid Lines and Fittings; (3) Mechanics Requirements, Privileges and Limitations; (4) Maintenance Publications; and, (5) Maintenance forms and Records. It is a basic course of knowledge and skills necessary to any…

  8. Comparison of gefitinib as first- and second-line therapy for advanced lung adenocarcinoma patients with positive exon 21 or 19 del epidermal growth factor receptor mutation

    Directory of Open Access Journals (Sweden)

    Patel N

    2017-06-01

    Full Text Available Nishant Patel,1 Pingping Wu,2 Haijun Zhang1 1Department of Oncology, Zhongda Hospital, Medical School, Southeast University, 2Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, People’s Republic of China Objectives: Gefitinib, a tyrosine kinase inhibitor (TKI targeting epidermal growth factor receptor (EGFR, shows excellent clinical benefit in treating advanced non-small-cell lung cancer (NSCLC. The aim of this study was to compare the efficacy and toxicity of gefitinib as first-line therapy and second-line therapy for advanced lung adenocarcinoma patients with positive exon 21 (L858R or exon 19 deletion of EGFR mutation. Methods: We retrospectively analyzed the clinical data of 60 EGFR-mutated advanced lung adenocarcinoma patients from July 2011 to November 2015 who have received oral gefitinib 250 mg once daily. Gefitinib was taken until disease progression, intolerable toxicity or death. Results: After a median follow-up of 792 days, one death had occurred. Among the 59 patients who survived, 17 patients progressed. Overall, the median progression-free survival (mPFS was 10 months (95% confidence interval [CI]: 7.53–12.46 months, p<0.05. The response rate (RR and disease control rate (DCR were 33.33% and 71.66%, respectively. However, there was longer mPFS in the first line-therapy than that in the second-line therapy: in the first-line gefitinib therapy, mPFS was 12 months among 41 patients (95% CI: 9.58–14.41 months, p<0.05, and in the second-line therapy, mPFS was 7 months among 19 patients (95% CI: 1.31–12.68 months, p<0.05. Furthermore, in subgroup analyses examining different EGFR mutation types, we noted that mPFS was significantly longer for patients with exon 19 deletion than for those with positive exon 21in both the first-line therapy and second-line therapy. Conclusion: Patients with advance lung adenocarcinoma who were selected by positive exon 21 or 19 deletion mutations had significantly longer m

  9. Research on Special Maintenance Tool of Straight Line Tower Ground and OPGW Cable in Overhead Transmission Line%线路直线塔地线及光缆金具维护

    Institute of Scientific and Technical Information of China (English)

    杨军

    2014-01-01

    本文在对架空输电线路直线塔地线支架和地线、 OPGW光缆金具组装方式及杆塔荷载的分析计算基础上,结合机械设计基础理论,确定了初步的专用工具研制方案。通过自行购买材料、零部件,在加工、装配和试用过程中不断完善后,成功研制出一套地线、 OPGW光缆金具维护的专用工具。该专用工具通过在不同电压等级线路、荷载情况下的4次现场试用,完全满足对35 kV~500 kV线路通用通用直线塔地线、 OPGW光缆金具的维护工作,而且与传统的作业方法相比明显提高了作业安全性和工作效率。%Based on the basis of the calculation,combining with the basic mechanical design theory, and analysis of straight wire bracket and a ground wire,OPGW cable for overhead power transmission line and tower load, the special maintenance tool is pre-liminary designed. Through the purchase of materials, parts, continuous improvement in processing, assembly and trial process,successfully developed a set of wire,OPGW cable maintenance special tool. The special tool is through the field test for 4 times in different voltage grade line,load conditions,to meet the needs of 35 kV-500 kV line general linear tower wire,OPGW cable main-tenance work,and compared with the traditional operating method significantly improves the operation safety and efficiency.

  10. Far-infrared 14NH3 line positions and intensities measured with a FT-IR and AILES beamline, Synchrotron SOLEIL

    Science.gov (United States)

    Sung, Keeyoon; Yu, Shanshan; Pearson, John; Pirali, Olivier; Kwabia Tchana, Fridolin; Manceron, Laurent

    2016-09-01

    Extensive measurements of line positions and intensities are reported for the inversion-rotation and rovibrational transitions of 14NH3 in the 50-660 cm-1 region. This study analyzes high-resolution (0.00167 cm-1, unapodized) Fourier-transform spectra of high purity (99.5%) normal ammonia sample obtained using the AILES beamline of Synchrotron SOLEIL. The experimental conditions are designed to study transitions with intensities weaker than 1 × 10-22 cm-1/(molecule cm-2) at room temperature. Line positions and intensities of more than 2830 transitions of 14NH3 are measured and compiled after proper quality control; the features from minor isotopologues (15NH3 and NH2D) and H2O are identified and excluded. Based on the predictions of recent work from the empirical Hamiltonian modeling, systematic quantum assignments are made for 2047 transitions from eight bands including four inversion-rotation (gs, v2, 2v2, and v4) and four ro-vibrational bands (v2-gs, 2v2-v2, v4-v2, and 2v2-v4), as well as covering their ΔK = 3 forbidden transitions. The measured line positions for the assigned transitions are in an excellent agreement (typically better than 0.001 cm-1) with the predictions in a wide range of J and K for all the eight bands. The comparison with the HITRAN 2012 database is also satisfactory, although systematic offsets are seen for transitions with high J and K and those from weak bands. Also we note that out of the eight bands, the 2v2-v4 has not been listed in the HITRAN 2012 database. Differences of 20% are seen between our measured and calculated intensities depending on the bands. For line positions, greater differences are found for some NH3 bands in HITRAN 2012 than recent predictions. Measurements of the individual line positions and intensities are presented for the eight bands, and the final spectroscopic line positions and intensities are compiled as an electronic supplement.

  11. Line parameter study of ozone at 5 and 10 μm using atmospheric FTIR spectra from the ground: A spectroscopic database and wavelength region comparison

    Science.gov (United States)

    Janssen, Christof; Boursier, Corinne; Jeseck, Pascal; Té, Yao

    2016-08-01

    Atmospheric ozone concentration measurements mostly depend on spectroscopic methods that cover different spectral regions. Despite long years of measurement efforts, the uncertainty goal of 1% in absolute line intensities has not yet been reached. Multispectral inter-comparisons using both laboratory and atmospheric studies reveal that important discrepancies exist when ozone columns are retrieved from different spectral regions. Here, we use ground based FTIR to study the sensitivity of ozone columns on different spectroscopic parameters as a function of individual bands for identifying necessary improvements of the spectroscopic databases. In particular, we examine the degree of consistency that can be reached in ozone retrievals using spectral windows in the 5 and 10 μm bands of ozone. Based on the atmospheric spectra, a detailed database inter-comparison between HITRAN (version 2012), GEISA (version 2011) and S&MPO (as retrieved from the website at the end of 2015) is made. Data from the 10 μm window are consistent to better than 1%, but there are larger differences when the windows at 5 μm are included. The 5 μm results agree with the results from 10 μm within ±2% for all databases. Recent S&MPO data are even more consistent with the desired level of 1%, but spectroscopic data from HITRAN give about 4% higher ozone columns than those from GEISA. If four sub-windows in the 5 μm band are checked for consistency, retrievals using GEISA or S&MPO parameters show less dispersion than those using HITRAN, where one window in the P-branch of the ν1 + ν3 band gives about 2% lower results than the other three. The atmospheric observations are corroborated by a direct comparison of the spectroscopic databases, using a simple statistical analysis based on intensity weighted spectroscopic parameters. The bias introduced by the weighted average approach is investigated and it is negligible if relative differences between databases do not correlate with line

  12. Positive Predictive Value of the WHO Clinical and Immunologic Criteria to Predict Viral Load Failure among Adults on First, or Second-Line Antiretroviral Therapy in Kenya.

    Directory of Open Access Journals (Sweden)

    Anthony Waruru

    Full Text Available Routine HIV viral load (VL monitoring is the standard of care for persons receiving antiretroviral therapy (ART in developed countries. Although the World Health Organization recommends annual VL monitoring of patients on ART, recognizing difficulties in conducting routine VL testing, the WHO continues to recommend targeted VL testing to confirm treatment failure for persons who meet selected immunologic and clinical criteria. Studies have measured positive predictive value (PPV, negative predictive value, sensitivity and specificity of these criteria among patients receiving first-line ART but not specifically among those on second-line or subsequent regimens. Between 2008 and 2011, adult ART patients in Nyanza, Kenya who met national clinical or immunologic criteria for treatment failure received targeted VL testing. We calculated PPV and 95% confidence intervals (CI of these criteria to detect virologic treatment failure among patients receiving a first-line ART, b second/subsequent ART, and c any regimen. Of 12,134 patient specimens tested, 2,874 (23.7% were virologically confirmed as treatment failures. The PPV for 2,834 first-line ART patients who met either the clinical or immunologic criteria for treatment failure was 34.4% (95% CI 33.2-35.7, 33.1% (95% CI 24.7-42.3 for the 40 patients on second-line/subsequent regimens, and 33.4% (95% CI 33.1-35.6 for any ART. PPV, regardless of criteria, for first-line ART patients was lowest among patients over 44 years old and highest for patients aged 15 to 34 years. PPV of immunological and clinical criteria for correctly identifying treatment failure was similarly low for adult patients receiving either first-line or second-line/subsequent ART regimens. Our data confirm the inadequacy of clinical and immunologic criteria to correctly identify treatment failure and support the implementation of routine VL testing.

  13. Positive Predictive Value of the WHO Clinical and Immunologic Criteria to Predict Viral Load Failure among Adults on First, or Second-Line Antiretroviral Therapy in Kenya.

    Science.gov (United States)

    Waruru, Anthony; Muttai, Hellen; Ng'ang'a, Lucy; Ackers, Marta; Kim, Andrea; Miruka, Fredrick; Erick, Opiyo; Okonji, Julie; Ayuaya, Tolbert; Schwarcz, Sandra

    2016-01-01

    Routine HIV viral load (VL) monitoring is the standard of care for persons receiving antiretroviral therapy (ART) in developed countries. Although the World Health Organization recommends annual VL monitoring of patients on ART, recognizing difficulties in conducting routine VL testing, the WHO continues to recommend targeted VL testing to confirm treatment failure for persons who meet selected immunologic and clinical criteria. Studies have measured positive predictive value (PPV), negative predictive value, sensitivity and specificity of these criteria among patients receiving first-line ART but not specifically among those on second-line or subsequent regimens. Between 2008 and 2011, adult ART patients in Nyanza, Kenya who met national clinical or immunologic criteria for treatment failure received targeted VL testing. We calculated PPV and 95% confidence intervals (CI) of these criteria to detect virologic treatment failure among patients receiving a) first-line ART, b) second/subsequent ART, and c) any regimen. Of 12,134 patient specimens tested, 2,874 (23.7%) were virologically confirmed as treatment failures. The PPV for 2,834 first-line ART patients who met either the clinical or immunologic criteria for treatment failure was 34.4% (95% CI 33.2-35.7), 33.1% (95% CI 24.7-42.3) for the 40 patients on second-line/subsequent regimens, and 33.4% (95% CI 33.1-35.6) for any ART. PPV, regardless of criteria, for first-line ART patients was lowest among patients over 44 years old and highest for patients aged 15 to 34 years. PPV of immunological and clinical criteria for correctly identifying treatment failure was similarly low for adult patients receiving either first-line or second-line/subsequent ART regimens. Our data confirm the inadequacy of clinical and immunologic criteria to correctly identify treatment failure and support the implementation of routine VL testing.

  14. The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus.

    Directory of Open Access Journals (Sweden)

    Bryan E Luu

    Full Text Available Hibernation is an adaptive strategy used by various mammals to survive the winter under situations of low ambient temperatures and limited or no food availability. The heart of hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus has the remarkable ability to descend to low, near 0°C temperatures without falling into cardiac arrest. We hypothesized that the transcription factors GATA4 and Nkx2-5 may play a role in cardioprotection by facilitating the expression of key downstream targets such as troponin I, troponin C, and ANP (atrial natriuretic peptide. This study measured relative changes in transcript levels, protein levels, protein post-translational modifications, and transcription factor binding over six stages: euthermic control (EC, entrance into torpor (EN, early torpor (ET, late torpor (LT, early arousal (EA, and interbout arousal (IA. We found differential regulation of GATA4 whereby transcript/protein expression, post-translational modification (phosphorylation of serine 261, and DNA binding were enhanced during the transitory phases (entrance and arousal of hibernation. Activation of GATA4 was paired with increases in cardiac troponin I, troponin C and ANP protein levels during entrance, while increases in p-GATA4 DNA binding during early arousal was paired with decreases in troponin I and no changes in troponin C and ANP protein levels. Unlike its binding partner, the relative mRNA/protein expression and DNA binding of Nkx2-5 did not change during hibernation. This suggests that either Nkx2-5 does not play a substantial role or other regulatory mechanisms not presently studied (e.g. posttranslational modifications are important during hibernation. The data suggest a significant role for GATA4-mediated gene transcription in the differential regulation of genes which aid cardiac-specific challenges associated with torpor-arousal.

  15. Hibernation alters the diversity and composition of mucosa-associated bacteria while enhancing antimicrobial defence in the gut of 13-lined ground squirrels.

    Science.gov (United States)

    Dill-McFarland, Kimberly A; Neil, Katie L; Zeng, Austin; Sprenger, Ryan J; Kurtz, Courtney C; Suen, Garret; Carey, Hannah V

    2014-09-01

    The gut microbiota plays important roles in animal nutrition and health. This relationship is particularly dynamic in hibernating mammals where fasting drives the gut community to rely on host-derived nutrients instead of exogenous substrates. We used 16S rRNA pyrosequencing and caecal tissue protein analysis to investigate the effects of hibernation on the mucosa-associated bacterial microbiota and host responses in 13-lined ground squirrels. The mucosal microbiota was less diverse in winter hibernators than in actively feeding spring and summer squirrels. UniFrac analysis revealed distinct summer and late winter microbiota clusters, while spring and early winter clusters overlapped slightly, consistent with their transitional structures. Communities in all seasons were dominated by Firmicutes and Bacteroidetes, with lesser contributions from Proteobacteria, Verrucomicrobia, Tenericutes and Actinobacteria. Hibernators had lower relative abundances of Firmicutes, which include genera that prefer plant polysaccharides, and higher abundances of Bacteroidetes and Verrucomicrobia, some of which can survive solely on host-derived mucins. A core mucosal assemblage of nine operational taxonomic units shared among all individuals was identified with an average total sequence abundance of 60.2%. This core community, together with moderate shifts in specific taxa, indicates that the mucosal microbiota remains relatively stable over the annual cycle yet responds to substrate changes while potentially serving as a pool for 'seeding' the microbiota once exogenous substrates return in spring. Relative to summer, hibernation reduced caecal crypt length and increased MUC2 expression in early winter and spring. Hibernation also decreased caecal TLR4 and increased TLR5 expression, suggesting a protective response that minimizes inflammation.

  16. Characterization of the SIRT family of NAD+-dependent protein deacetylases in the context of a mammalian model of hibernation, the thirteen-lined ground squirrel.

    Science.gov (United States)

    Rouble, Andrew N; Storey, Kenneth B

    2015-10-01

    Hibernating mammals employ strong metabolic rate depression to survive the winter, thereby avoiding the high energy costs of maintaining a euthermic lifestyle in the face of low seasonal temperatures and limited food resources. Characteristics of this natural torpor include a significant reduction in body temperature, a shift to a lipid-based metabolism, global suppression of ATP-expensive activities, and the upregulation of selected genes that mediate biochemical reorganization and cytoprotection. Sirtuin (SIRT) proteins, an evolutionarily conserved family of NAD(+)-dependent protein deacetylases, have been shown to play important roles in the post-translational regulation of many metabolic and cytoprotective processes, suggesting a potential function for these enzymes in the control of hibernation. To assess this possibility, protein levels of the seven mammalian SIRTs (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7), total SIRT activity, and the acetylation status of two downstream SIRT targets (SOD2K68 and NF-κB p65K310) were measured in skeletal muscle, liver, brown adipose and white adipose tissues of the hibernating thirteen-lined ground squirrel (Ictidomys tridecemlineatus) over the course of the torpor-arousal cycle. The analysis revealed tissue-specific responses of different SIRTs at various points throughout hibernation, including a potentially interesting correlation between increased levels of SIRT3 protein, heightened total SIRT activity, and decreased acetylation of SIRT3 downstream target SOD2K68 in skeletal muscle during late torpor. These results provide evidence to suggest a possible role for the SIRT family of protein deacetylases in the regulation of the metabolic and cellular protective pathways that mediate the process of mammalian hibernation.

  17. The aqueous extract of Ficus religiosa induces cell cycle arrest in human cervical cancer cell lines SiHa (HPV-16 Positive and apoptosis in HeLa (HPV-18 positive.

    Directory of Open Access Journals (Sweden)

    Amit S Choudhari

    Full Text Available Natural products are being extensively explored for their potential to prevent as well as treat cancer due to their ability to target multiple molecular pathways. Ficus religiosa has been shown to exert diverse biological activities including apoptosis in breast cancer cell lines. In the present study, we report the anti-neoplastic potential of aqueous extract of F. religiosa (FRaq bark in human cervical cancer cell lines, SiHa and HeLa. FRaq altered the growth kinetics of SiHa (HPV-16 positive and HeLa (HPV-18 positive cells in a dose-dependent manner. It blocked the cell cycle progression at G1/S phase in SiHa that was characterized by an increase in the expression of p53, p21 and pRb proteins with a simultaneous decrease in the expression of phospho Rb (ppRb protein. On the other hand, in HeLa, FRaq induced apoptosis through an increase in intracellular Ca(2+ leading to loss of mitochondrial membrane potential, release of cytochrome-c and increase in the expression of caspase-3. Moreover, FRaq reduced the migration as well as invasion capability of both the cervical cancer cell lines accompanied with downregulation of MMP-2 and Her-2 expression. Interestingly, FRaq reduced the expression of viral oncoproteins E6 and E7 in both the cervical cancer cell lines. All these data suggest that F. religiosa could be explored for its chemopreventive potential in cervical cancer.

  18. MCSCF/CI ground state potential energy surface, dipole moment function, and gas phase vibrational frequencies for the nitrogen dioxide positive ion

    Energy Technology Data Exchange (ETDEWEB)

    Hopper, D.G.

    1980-05-01

    The ground state potential energy surface for the nitrogen dioxide positive ion, NO/sup +//sub 2/X /sup 1/..sigma../sup +//sub g/(..sigma../sup +/,A/sub 1/,A'), has been scanned with a correlated wave function to obtain directly, for the first time, the gas phase equilibrium geometry, force constants, vibrational frequencies, and dipole moment function. The wave function for this scan was constructed from a double-zeta plus polarization one-electron basis with a 12 configuration MCSCF determination of the orbital basis for a full valence /sup 1/..sigma../sup +//sub g/ configuration interaction expansion. The calculated equilibrium bond length is 1.12 A. The vibrational frequencies are computed to be ..nu../sub 1/=1514, ..nu../sub 2/=679, and ..nu../sub 3/=2614 cm/sup -1/ The present ab initio results differ significantly from crystalline spectroscopic studies and are, thus, the best values available for the gas phase vibrational frequencies. The dipole moment function is nonzero at the ..sigma../sup +/, A/sub 1/, and A' geometries included in the potential surface scan, and is obtained here to provide for the future a priori calculation of the infrared band intensities.

  19. Toral lateral line units of goldfish, Carassius auratus, are sensitive to the position and vibration direction of a vibrating sphere.

    Science.gov (United States)

    Meyer, Gunnar; Klein, Adrian; Mogdans, Joachim; Bleckmann, Horst

    2012-09-01

    We recorded the responses of lateral line units in the midbrain torus semicircularis of goldfish, Carassius auratus, to a 50-Hz vibrating sphere and determined the unit's spatial receptive fields for various distances between fish and sphere and for different directions of sphere vibration. All but one unit responded to the vibrating sphere with an increase in discharge rate. Only a proportion (25%) of the units exhibited phase-locked responses. Receptive fields were narrow or broad and contained one, two or more areas of increased discharge rate. The data show that the receptive fields of toral lateral line units are in many respects similar to those of brainstem units but differ from those of afferent nerve fibres. The responses of primary afferents represent the pressure gradient pattern generated by a vibrating sphere and provide information about sphere location and vibration direction. Across the array of lateral line neuromasts, the fish brain in principle can derive this information. Nevertheless, toral units tuned to a distinct sphere location or sensitive to a distinct sphere vibration direction were not found. Therefore, it is conceivable that the torus semicircularis uses a population code to determine spatial location and vibration direction of a vibrating sphere.

  20. In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel {sup 99m}Tc-radiofolate tracer

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Cristina [Paul Scherrer Institute, Center for Radiopharmaceutical Science ETH-PSI-USZ, Villigen-PSI (Switzerland); Schubiger, P.A.; Schibli, Roger [Paul Scherrer Institute, Center for Radiopharmaceutical Science ETH-PSI-USZ, Villigen-PSI (Switzerland); Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich (Switzerland)

    2006-10-15

    For the assessment of folate-based radiopharmaceuticals, human nasopharyngeal KB carcinoma cells are traditionally used although nasopharyngeal cancer is rare. On the other hand, the folate receptor (FR) is frequently overexpressed on diverse cancer types, the highest frequency (>90%) being on ovarian carcinomas. The goal of our study was the in vitro and in vivo assessment of different FR-positive human carcinoma cells. In addition, a murine sarcoma cell line was assessed as a pre-clinical alternative to human xenograft models. FR-positive human nasopharyngeal, cervical, ovarian and colorectal cancer cell lines and the transgenic mouse sarcoma (24JK-FBP) cell line were targeted with a novel {sup 99m}Tc-tricarbonyl folate derivative 2. Comparative in vitro cell binding studies were carried out under standardised folate-deficient conditions. In vivo studies were performed in nude mice and C6 black mice. The in vitro cell experiments revealed only FR-specific binding (unspecific <0.02%), ranging from 3.5% to 52% of complex 2 owing to variable levels of FR expression of the cell lines. In vivo tumour uptake of radiotracer 2 varied less than in vitro. It ranged from 0.66{+-}0.17% ID/g (LoVo) through 1.16{+-}0.64% ID/g (IGROV-1) and 1.55{+-}0.43% ID/g (24JK-FBP) to 2.33{+-}0.36% ID/g (KB) 4 h p.i. These pre-clinical studies indicate that in vitro data obtained in FR-positive cancer cells do not necessarily correspond with or predict in vivo radiofolate uptake in corresponding (xeno)grafts. In addition, the murine 24JK-FBP cell line proved to be a valuable pre-clinical alternative to human tumour models. (orig.)

  1. Effect of head and neck position on vertical ground reaction forces and interlimb coordination in the dressage horse ridden at walk and trot on a treadmill.

    Science.gov (United States)

    Weishaupt, M A; Wiestner, T; von Peinen, K; Waldern, N; Roepstorff, L; van Weeren, R; Meyer, H; Johnston, C

    2006-08-01

    Little is known in quantitative terms about the influence of different head-neck positions (HNPs) on the loading pattern of the locomotor apparatus. Therefore it is difficult to predict whether a specific riding technique is beneficial for the horse or if it may increase the risk for injury. To improve the understanding of forelimb-hindlimb balance and its underlying temporal changes in relation to different head and neck positions. Vertical ground reaction force and time parameters of each limb were measured in 7 high level dressage horses while being ridden at walk and trot on an instrumented treadmill in 6 predetermined HNPs: HNP1 - free, unrestrained with loose reins; HNP2 - neck raised, bridge of the nose in front of the vertical; HNP3 - neck raised, bridge of the nose behind the vertical; HNP4 - neck lowered and flexed, bridge of the nose considerably behind the vertical; HNP5 - neck extremely elevated and bridge of the nose considerably in front of the vertical; HNP6 - neck and head extended forward and downward. Positions were judged by a qualified dressage judge. HNPs were assessed by comparing the data to a velocity-matched reference HNP (HNP2). Differences were tested using paired t test or Wilcoxon signed rank test (Pwalk, stride duration and overreach distance increased in HNP1, but decreased in HNP3 and HNP5. Stride impulse was shifted to the forehand in HNP1 and HNP6, but shifted to the hindquarters in HNP5. At the trot, stride duration increased in HNP4 and HNP5. Overreach distance was shorter in HNP4. Stride impulse shifted to the hindquarters in HNP5. In HNP1 peak forces decreased in the forelimbs; in HNP5 peak forces increased in fore- and hindlimbs. HNP5 had the biggest impact on limb timing and load distribution and behaved inversely to HNP1 and HNP6. Shortening of forelimb stance duration in HNP5 increased peak forces although the percentage of stride impulse carried by the forelimbs decreased. An extremely high HNP affects functionality much

  2. Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells

    Science.gov (United States)

    Liu, P; Brown, S; Goktug, T; Channathodiyil, P; Kannappan, V; Hugnot, J-P; Guichet, P-O; Bian, X; Armesilla, A L; Darling, J L; Wang, W

    2012-01-01

    Background: Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram (DS), an aldehyde dehydrogenase (ALDH) inhibitor, targets breast CSC-like cells. In this study, the effect of DS and combination of DS and gemcitabine (dFdC) on GBM cells and GBM stem-like cells was investigated. Methods: 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan (MTT), combination index (CI)-isobologram, western blot, luciferase reporter gene assay, electrophoretic mobility-shift assay and ALDH analysis were used in this study. Results: Disulfiram is cytotoxic in GBM cell lines in a copper (Cu)-dependent manner. Disulfiram/copper enhances the cytotoxicity of dFdC. Combination index-isobologram analysis indicates a synergistic effect between DS/Cu and dFdC. Disulfiram/copper induces reactive oxygen species (ROS), activates JNK and p38 pathways and inhibits nuclear factor-kappa B activity in GBM cell lines. Disulfiram/copper may trigger intrinsic apoptotic pathway via modulation of the Bcl2 family. Disulfiram/copper abolishes stem-like cell population in GBM cell lines. Conclusion: Our findings indicate that the cytotoxicity of DS/Cu and the enhancing effect of DS/Cu on the cytotoxicity of dFdC in GBM stem-like cells may be caused by induction of ROS and inhibition of both ALDH and the NFkB pathway. Both DS and dFdC can traverse the blood–brain barrier. Further study may lead them into GBM chemotherapy. PMID:23033007

  3. Characterization of T cell receptor assembly and expression in a Ti gamma delta-positive cell line

    DEFF Research Database (Denmark)

    Kuhlmann, J; Caspar-Bauguil, S; Geisler, C;

    1993-01-01

    of the various components of this multimeric protein complex is still not fully understood. In this report, the human leukemic T cell line Lyon which expresses a Ti-gamma delta/CD3 complex, was characterized and compared to another human leukemic T cell line Jurkat (Ti-alpha beta/CD3). Membrane TCR-/CD3......T cell antigen receptor (TcR) heterodimers of both the Ti-alpha beta and Ti-gamma delta types are expressed at the surface of T cells noncovalently associated with the CD3 complex composed of the monomorphic chains gamma, delta, epsilon and zeta. The structural relationship and assembly......- variants of the T cell Lyon were induced and found to produce all of the Ti/CD3 components, with the exception of Ti-delta. Biochemical analysis indicated that: (1) Ti-gamma/CD3 gamma, delta, epsilon complexes were formed in the endoplasmic reticulum in the absence of Ti-delta; (2) the CD3-zeta chain did...

  4. The silver lining of a mind in the clouds: interesting musings are associated with positive mood while mind-wandering.

    Science.gov (United States)

    Franklin, Michael S; Mrazek, Michael D; Anderson, Craig L; Smallwood, Jonathan; Kingstone, Alan; Schooler, Jonathan W

    2013-01-01

    The negative effects of mind-wandering on performance and mood have been widely documented. In a recent well-cited study, Killingsworth and Gilbert (2010) conducted a large experience sampling study revealing that all off-task episodes, regardless of content, have equal to or lower happiness ratings, than on-task episodes. We present data from a similarly implemented experience sampling study with additional mind-wandering content categories. Our results largely conform to those of the Killingsworth and Gilbert (2010) study, with mind-wandering generally being associated with a more negative mood. However, subsequent analyses reveal situations in which a more positive mood is reported after being off-task. Specifically when off-task episodes are rated for interest, the high interest episodes are associated with an increase in positive mood compared to all on-task episodes. These findings both identify a situation in which mind-wandering may have positive effects on mood, and suggest the possible benefits of encouraging individuals to shift their off-task musings to the topics they find most engaging.

  5. The silver lining of a mind in the clouds: Interesting musings are associated with positive mood while mind-wandering

    Directory of Open Access Journals (Sweden)

    Michael S. Franklin

    2013-08-01

    Full Text Available The negative effects of mind-wandering on performance and mood have been widely documented. In a recent well-cited study, Killingsworth and Gilbert (2010 conducted a large experience sampling study revealing that all off-task episodes, regardless of content, have equal to or lower happiness ratings, than on-task episodes. We present data from a similarly implemented experience sampling study with additional mind-wandering content categories. Our results largely conform to those of the Killingsworth and Gilbert (2010 study, with mind-wandering generally being associated with a more negative mood. However, subsequent analyses reveal situations in which a more positive mood is reported after being off-task. Specifically when off-task episodes are rated for interest, the high interest episodes are associated with an increase in positive mood compared to all on-task episodes. These findings both identify a situation in which mind-wandering may have positive effects on mood, and suggest the possible benefits of encouraging individuals to shift their off task musings to the topics they find most engaging.

  6. The silver lining of a mind in the clouds: interesting musings are associated with positive mood while mind-wandering

    Science.gov (United States)

    Franklin, Michael S.; Mrazek, Michael D.; Anderson, Craig L.; Smallwood, Jonathan; Kingstone, Alan; Schooler, Jonathan W.

    2013-01-01

    The negative effects of mind-wandering on performance and mood have been widely documented. In a recent well-cited study, Killingsworth and Gilbert (2010) conducted a large experience sampling study revealing that all off-task episodes, regardless of content, have equal to or lower happiness ratings, than on-task episodes. We present data from a similarly implemented experience sampling study with additional mind-wandering content categories. Our results largely conform to those of the Killingsworth and Gilbert (2010) study, with mind-wandering generally being associated with a more negative mood. However, subsequent analyses reveal situations in which a more positive mood is reported after being off-task. Specifically when off-task episodes are rated for interest, the high interest episodes are associated with an increase in positive mood compared to all on-task episodes. These findings both identify a situation in which mind-wandering may have positive effects on mood, and suggest the possible benefits of encouraging individuals to shift their off-task musings to the topics they find most engaging. PMID:24009599

  7. Influence of different head-neck positions on vertical ground reaction forces, linear and time parameters in the unridden horse walking and trotting on a treadmill.

    Science.gov (United States)

    Waldern, N M; Wiestner, T; von Peinen, K; Gómez Alvarez, C G; Roepstorff, L; Johnston, C; Meyer, H; Weishaupt, M A

    2009-03-01

    It is believed that the head-neck position (HNP) has specific effects on the loading pattern of the equine locomotor system, but very few quantitative data are available. To quantify the effects of 6 different HNPs on forelimb-hindlimb loading and underlying temporal changes. Vertical ground reaction forces of each limb and interlimb coordination were measured in 7 high level dressage horses walking and trotting on an instrumented treadmill in 6 predetermined HNPs: HNP1--unrestrained; HNP2--elevated neck, bridge of the nose in front of the vertical; HNP3--elevated neck, bridge of the nose behind the vertical; HNP4--low and flexed neck; HNP5--head and neck in extreme high position; and HNP6--forward downward extension of head and neck. HNP1 served as a velocity-matched control. At the walk, the percentage of vertical stride impulse carried by the forehand (Iz(fore)) as well as stride length and overreach distance were decreased in HNP2, HNP3, HNP4 and HNP5 when compared to HNP1. At the trot, Iz(fore) was decreased in HNP2, HNP3, HNP4 and HNP5. Peak forces in the forelimbs increased in HNP5 and decreased in HNP6. Stance duration in the forelimbs was decreased in HNP2 and HNP5. Suspension duration was increased in HNP2, HNP3 and HNP5. Overreach distance was shorter in HNP4 and longer in HNP6. In comparison to HNP1 and HNP6, HNPs with elevation of the neck with either flexion or extension at the poll as well as a low and flexed head and neck lead to a weight shift from the forehand to the hindquarters. HNP5 had the biggest effect on limb timing and load distribution. At the trot, shortening of forelimb stance duration in HNP5 increased peak vertical forces although Iz(fore) decreased. Presented results contribute to the understanding of the value of certain HNPs in horse training.

  8. Isolation and characterization of a metastatic hybrid cell line generated by ER negative and ER positive breast cancer cells in mouse bone marrow.

    Directory of Open Access Journals (Sweden)

    Keya De Mukhopadhyay

    Full Text Available BACKGROUND: The origin and the contribution of breast tumor heterogeneity to its progression are not clear. We investigated the effect of a growing orthotopic tumor formed by an aggressive estrogen receptor (ER-negative breast cancer cell line on the metastatic potential of a less aggressive ER-positive breast cancer cell line for the elucidation of how the presence of heterogeneous cancer cells might affect each other's metastatic behavior. METHODS: ER positive ZR-75-1/GFP/puro cells, resistant to puromycin and non-tumorigenic/non-metastatic without exogenous estrogen supplementation, were injected intracardiacally into mice bearing growing orthotopic tumors, formed by ER negative MDA-MB-231/GFP/Neo cells resistant to G418. A variant cell line B6, containing both estrogen-dependent and -independent cells, were isolated from GFP expressing cells in the bone marrow and re-inoculated in nude mice to generate an estrogen-independent cell line B6TC. RESULTS: The presence of ER negative orthotopic tumors resulted in bone metastasis of ZR-75-1 without estrogen supplementation. The newly established B6TC cell line was tumorigenic without estrogen supplementation and resistant to both puromycin and G418 suggesting its origin from the fusion of MDA-MB-231/GFP/Neo and ZR-75-1/GFP/puro in the mouse bone marrow. Compared to parental cells, B6TC cells were more metastatic to lung and bone after intracardiac inoculation. More significantly, B6TC mice also developed brain metastasis, which was not observed in the MDA-MB-231/GFP/Neo cell-inoculated mice. Low expression of ERα and CD24, and high expression of EMT-related markers such as Vimentin, CXCR4, and Integrin-β1 along with high CD44 and ALDH expression indicated stem cell-like characteristics of B6TC. Gene microarray analysis demonstrated a significantly different gene expression profile of B6TC in comparison to those of parental cell lines. CONCLUSIONS: Spontaneous generation of the novel hybrid cell

  9. Primary Multidrug Resistant Tuberculosis and Utility of Line Probe Assay for Its Detection in Smear-Positive Sputum Samples in a Tertiary Care Hospital in South India

    Directory of Open Access Journals (Sweden)

    Fahmiya Leena Yacoob

    2016-01-01

    Full Text Available In a high tuberculosis burdened country like India, rapid, cost-effective, and reliable diagnostic tools for tuberculosis are an urgent need of the hour to prevent inappropriate treatment strategies and further spread of resistance. This study aimed to estimate the proportion of new smear-positive tuberculosis cases with primary resistance to rifampicin and/or isoniazid as well as identify the common mutations associated with it. Sputum of 200 newly diagnosed smear-positive cases of 1+ score and above was directly subjected to Line Probe Assay using the GenoType MTBDRplus assay kit. All samples were inoculated onto solid media and 61 samples were inoculated in automated liquid culture also. The Line Probe Assay gave hundred percent interpretable results with 2.5% of the study population showing resistant pattern. Only 1% of the cases were primary multidrug resistant tuberculosis and 1.5% showed isoniazid monoresistance. S531L and C15T were the most common genetic mutations seen for rifampicin and isoniazid resistance, respectively. 40% had absent rpoB wild type 8 band indicating probable silent mutation after clinical correlation. The average turnaround time for Line Probe Assay was far less (3.8 days as compared to solid and liquid cultures (35.6 days and 13.5 days, resp..

  10. Immunocapture of CD133-positive cells from human cancer cell lines by using monodisperse magnetic poly(glycidyl methacrylate) microspheres containing amino groups

    Energy Technology Data Exchange (ETDEWEB)

    Kuan, Wei-Chih [Department of Chemical Engineering, Systems Biology and Tissue Engineering Research Center, National Chung Cheng University, Minhisung 621, Taiwan (China); Horák, Daniel, E-mail: horak@imc.cas.cz [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6 (Czech Republic); Plichta, Zdeněk [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6 (Czech Republic); Lee, Wen-Chien [Department of Chemical Engineering, Systems Biology and Tissue Engineering Research Center, National Chung Cheng University, Minhisung 621, Taiwan (China)

    2014-01-01

    Magnetic poly(glycidyl methacrylate)-based macroporous microspheres with an average particle size of 4.2 μm were prepared using a modified multi-step swelling polymerization method and by introducing amino functionality on their surfaces. Antibody molecules were oxidized on their carbohydrate moieties and bound to the amino-containing magnetic microspheres via a site-directed procedure. CD133-positive cells could be effectively captured from human cancer cell lines (HepG2, HCT116, MCF7, and IMR-32) by using magnetic microspheres conjugated to an anti-human CD133 antibody. After further culture, the immunocaptured CD133-expressing cells from IMR-32 proliferated and gradually detached from the magnetic microspheres. Flow-cytometric analysis confirmed the enrichment of CD133-expressing cells by using the antibody-bound magnetic microspheres. Such microspheres suitable for immunocapture are very promising for cancer diagnosis because the CD133-expressing cells in cancer cell lines have been suggested to be cancer stem cells. - Highlights: • Multi-step swelling polymerization produced poly(glycidyl methacrylate) microspheres. • Anti-human CD133 antibodies were bound to the amino-containing magnetic microspheres. • CD133-positive cells were effectively captured from human cancer cell lines. • Immunocaptured CD133-expressing cells proliferated and were detached from microspheres. • Enrichment of CD133-expressing cells was confirmed by flow-cytometric analysis.

  11. Existence and Global Asymptotic Behavior of Positive Solutions for Nonlinear Fractional Dirichlet Problems on the Half-Line

    Directory of Open Access Journals (Sweden)

    Imed Bachar

    2014-01-01

    Full Text Available We are interested in the following fractional boundary value problem: Dαu(t+atuσ=0, t∈(0,∞, limt→0⁡t2-αu(t=0, limt→∞⁡t1-αu(t=0, where 1<α<2, σ∈(-1,1, Dα is the standard Riemann-Liouville fractional derivative, and a is a nonnegative continuous function on (0,∞ satisfying some appropriate assumptions related to Karamata regular variation theory. Using the Schauder fixed point theorem, we prove the existence and the uniqueness of a positive solution. We also give a global behavior of such solution.

  12. The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Mack, Hildegard I.D.; Munger, Karl, E-mail: kmunger@rics.bwh.harvard.edu

    2013-11-15

    Infection with high-risk human papillomaviruses is causally linked to cervical carcinogenesis. However, most lesions caused by high-risk HPV infections do not progress to cancer. Host cell mutations contribute to malignant progression but the molecular nature of such mutations is unknown. Based on a previous study that reported an association between liver kinase B1 (LKB1) tumor suppressor loss and poor outcome in cervical cancer, we sought to determine the molecular basis for this observation. LKB1-negative cervical and lung cancer cells were reconstituted with wild type or kinase defective LKB1 mutants and we examined the importance of LKB1 catalytic activity in known LKB1-regulated processes including inhibition of cell proliferation and elevated resistance to energy stress. Our studies revealed marked differences in the biological activities of two kinase defective LKB1 mutants in the various cell lines. Thus, our results suggest that LKB1 may be a cell-type specific tumor suppressor. - Highlights: • LKB1 is a tumor suppressor that is linked to Peutz-Jeghers syndrome. • Peutz-Jeghers syndrome patients have a high incidence of cervical cancer. • Cervical cancer is caused by HPV infections. • This study investigates LKB1 tumor suppressor activity in cervical cancer.

  13. Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the HERNATA study

    DEFF Research Database (Denmark)

    Andersson, Michael; Lidbrink, Elisabeth; Bjerre, Karsten;

    2011-01-01

    To evaluate docetaxel or vinorelbine, both with trastuzumab, as first-line therapy of human epidermal growth factor receptor 2-positive advanced breast cancer.......To evaluate docetaxel or vinorelbine, both with trastuzumab, as first-line therapy of human epidermal growth factor receptor 2-positive advanced breast cancer....

  14. MRI compatibility of position-sensitive photomultiplier depth-of-interaction PET detectors modules for in-line multimodality preclinical studies

    Energy Technology Data Exchange (ETDEWEB)

    Vaquero, J.J., E-mail: juanjose.vaquero@uc3m.es [Universidad Carlos III de Madrid, Departamento de Bioingeniería e Ingeniería Aeroespacial, Avda. de la Universidad 30 Leganés, 28911 Madrid (Spain); Instituto de Investigación Sanitaria Gregorio Marañón, Madrid (Spain); Sánchez, J.J. [Instituto de Investigación Sanitaria Gregorio Marañón, Madrid (Spain); Udías, J.M.; Cal-González, J. [Grupo de Física Nuclear, Departamento de Física Atómica, Molecular y Nuclear, Universidad Complutense de Madrid, CEI Moncloa, Madrid (Spain); Desco, M. [Universidad Carlos III de Madrid, Departamento de Bioingeniería e Ingeniería Aeroespacial, Avda. de la Universidad 30 Leganés, 28911 Madrid (Spain); Instituto de Investigación Sanitaria Gregorio Marañón, Madrid (Spain)

    2013-02-21

    This work addresses the feasibility of a small-animal, in-line PET/MR system based on Position-Sensitive Photo Multiplier Tubes (PS-PMTs). To this end, we measured the effects of static magnetic fields on the PS-PMTs performance in order to explore the minimal tandem separation between the PET and MR subsystems to preserve their respective performances. We concluded that it is possible to achieve minimal degradation of the PET scanner performance (after a system recalibration) if the magnetic field strength influencing the PET detectors is less than 1 mT and if it is oriented perpendicularly to the longitudinal axis of the tube. Therefore, we predict that it will be possible to maintain the PET image quality if it is placed outside the 1 mT line.

  15. De-Li-DAQ-2D - a new data acquisition system for position-sensitive neutron detectors with delay-line readout

    Science.gov (United States)

    Levchanovskiy, F. V.; Murashkevich, S. M.

    2016-09-01

    Software for a data acquisition system of modern one- and two-dimensional position-sensitive detectors with delay-line readout, which includes a software interface to a new electronic module De-Li-DAQ-2D with a USB interface, is presented. The new system after successful tests on the stand and on several spectrometers of the IBR-2 reactor has been integrated into the software complex SONIX+ [1]. The De-Li- DAQ-2D module [2] contains an 8-channel time-code converter (TDC-GPX) with a time resolution of 80 ps, field programmable gate array (FPGA), 1 Gbyte histogram memory and high-speed interface with a fiber-optic communication line. A real count rate is no less than 106 events/s. The De-Li-DAQ-2D module is implemented in the NIM standard. The De-Li-DAQ-2D module can operate in two modes: histogram mode and list mode.

  16. Comparison of positions of the trochlear groove line and the vertical midline of the pericondylar rectangle on axial computed tomography: a retrospective pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Nizic, Dinko [Zagreb University Hospital Center, Clinical Institute of Diagnostic and Interventional Radiology, Zagreb (Croatia)

    2012-09-15

    To compare the positions of the trochlear groove (TG) line and the vertical midline of the pericondylar rectangle on axial computed tomography (CT). A retrospective pilot study was conducted in February and March 2011 comprising 14 knees in 9 consecutive patients with patellofemoral pain, a normal trochlear angle (124 -145 ), and no medical record of prior knee surgery. After the axial CT image displaying the center of the trochlear groove (''reference cut'') with a normal trochlear angle was identified, the pericondylar rectangle was drawn and located in the first quadrant of the Cartesian rectangular coordinate system. The x-coordinates of the vertical lines passing through the most posterior point of the trochlear groove (TG line) and the midpoints of the horizontal sides of the pericondylar rectangle (vertical midline) were obtained at 2-week intervals and statistically analyzed as matched pairs for differences (Wilcoxon signed rank test), agreements (Bland-Altman plot, intraclass correlation coefficient [ICC]) and relative variations (coefficient of variation [CV]). There were no statistically significant differences between matched pairs (2-tailed p from 0.583 to 0.641) whereas the agreements were substantial (bias = -0.37 and -0.45 respectively, ICC = 0.688 and 0.670 respectively) to almost perfect for duplicate measurements (bias = 0.11 and 0.04 respectively, ICC = 0.975 and 0.998 respectively), with much less relative variation with regard to the vertical midline (CV = 1.22% to CV = 0.34% respectively). The positions of the TG line and the vertical midline of the pericondylar rectangle on axial CT were identical. The latter was identified regardless of trochlear morphology. (orig.)

  17. The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines.

    Science.gov (United States)

    Gwanmesia, Patricia Mambou; Romanski, Annette; Schwarz, Kerstin; Bacic, Biserka; Ruthardt, Martin; Ottmann, Oliver G

    2009-02-13

    Imatinib mesylate, a selective inhibitor of Abl tyrosine kinase, is efficacious in treating chronic myeloid leukaemia (CML) and Ph+ acute lymphoblastic leukaemia (ALL). However, most advanced-phase CML and Ph+ ALL patients relapse on Imatinib therapy. Several mechanisms of refractoriness have been reported, including the activation of the Src-family kinases (SFK). Here, we investigated the biological effect of the new specific dual Src/Abl kinase inhibitor AZD0530 on Ph+ leukaemic cells. Cell lines used included BV173 (CML in myeloid blast crisis), SEM t(4;11), Ba/F3 (IL-3 dependent murine pro B), p185Bcr-Abl infected Ba/F3 cells, p185Bcr-Abl mutant infected Ba/F3 cells, SupB15 (Ph+ ALL) and Imatinib resistant SupB15 (RTSupB15) (Ph+ ALL) cells. Cells were exposed to AZD0530 and Imatinib. Cell proliferation, apoptosis, survival and signalling pathways were assessed by dye exclusion, flow cytometry and Western blotting respectively. AZD0530 specifically inhibited the growth of, and induced apoptosis in CML and Ph+ ALL cells in a dose dependent manner, but showed only marginal effects on Ph- ALL cells. Resistance to Imatinib due to the mutation Y253F in p185Bcr-Abl was overcome by AZD0530. Combination of AZD0530 and Imatinib showed an additive inhibitory effect on the proliferation of CML BV173 cells but not on Ph+ ALL SupB15 cells. An ongoing transphosphorylation was demonstrated between SFKs and Bcr-Abl. AZD0530 significantly down-regulated the activation of survival signalling pathways in Ph+ cells, resistant or sensitive to Imatinib, with the exception of the RTSupB15. Our results indicate that AZD0530 targets both Src and Bcr-Abl kinase activity and reduces the leukaemic maintenance by Bcr-Abl.

  18. The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines

    Directory of Open Access Journals (Sweden)

    Ruthardt Martin

    2009-02-01

    Full Text Available Abstract Background Imatinib mesylate, a selective inhibitor of Abl tyrosine kinase, is efficacious in treating chronic myeloid leukaemia (CML and Ph+ acute lymphoblastic leukaemia (ALL. However, most advanced-phase CML and Ph+ ALL patients relapse on Imatinib therapy. Several mechanisms of refractoriness have been reported, including the activation of the Src-family kinases (SFK. Here, we investigated the biological effect of the new specific dual Src/Abl kinase inhibitor AZD0530 on Ph+ leukaemic cells. Methods Cell lines used included BV173 (CML in myeloid blast crisis, SEM t(4;11, Ba/F3 (IL-3 dependent murine pro B, p185Bcr-Abl infected Ba/F3 cells, p185Bcr-Abl mutant infected Ba/F3 cells, SupB15 (Ph+ ALL and Imatinib resistant SupB15 (RTSupB15 (Ph+ ALL cells. Cells were exposed to AZD0530 and Imatinib. Cell proliferation, apoptosis, survival and signalling pathways were assessed by dye exclusion, flow cytometry and Western blotting respectively. Results AZD0530 specifically inhibited the growth of, and induced apoptosis in CML and Ph+ ALL cells in a dose dependent manner, but showed only marginal effects on Ph- ALL cells. Resistance to Imatinib due to the mutation Y253F in p185Bcr-Abl was overcome by AZD0530. Combination of AZD0530 and Imatinib showed an additive inhibitory effect on the proliferation of CML BV173 cells but not on Ph+ ALL SupB15 cells. An ongoing transphosphorylation was demonstrated between SFKs and Bcr-Abl. AZD0530 significantly down-regulated the activation of survival signalling pathways in Ph+ cells, resistant or sensitive to Imatinib, with the exception of the RTSupB15. Conclusion Our results indicate that AZD0530 targets both Src and Bcr-Abl kinase activity and reduces the leukaemic maintenance by Bcr-Abl.

  19. 14NH_3 Line Positions and Intensities in the Far-Infrared Comparison of Ft-Ir Measurements to Empirical Hamiltonian Model Predictions

    Science.gov (United States)

    Sung, Keeyoon; Yu, Shanshan; Pearson, John; Pirali, Olivier; Kwabia Tchana, F.; Manceron, Laurent

    2016-06-01

    We have analyzed multiple spectra of high purity (99.5%) normal ammonia sample recorded at room temperatures using the FT-IR and AILES beamline at Synchrotron SOLEIL, France. More than 2830 line positions and intensities are measured for the inversion-rotation and rovibrational transitions in the 50 - 660 wn region. Quantum assignments were made for 2047 transitions from eight bands including four inversion-rotation bands (gs(a-s), νb{2}(a-s), 2νb{2}(a-s), and νb{4}(a-s)) and four ro-vibrational bands (νb{2} - gs, 2νb{2} - gs, νb{4} - νb{2}, and 2νb{2} -νb{4}), as well as covering more than 300 lines of ΔK = 3 forbidden transitions. Out of the eight bands, we note that 2νb{2} - νb{4} has not been listed in the HITRAN 2012 database. The measured line positions for the assigned transitions are in an excellent agreement (typically better than 0.001 wn) with the predictions from the empirical Hamiltonian model [S. Yu, J.C. Pearson, B.J. Drouin, et al.(2010)] in a wide range of J and K for all the eight bands. The comparison with the HITRAN 2012 database is also satisfactory, although systematic offsets are seen for transitions with high J and K and those from weak bands. However, differences of 20% or so are seen in line intensities for allowed transitions between the measurements and the model predictions, depending on the bands. We have also noticed that most of the intensity outliers in the Hamiltonian model predictions belong to transitions from gs(a-s) band. We present the final results of the FT-IR measurements of line positions and intensities, and their comparisons to the model predictions and the HITRAN 2012 database. Research described in this paper was performed at the Jet Propulsion Laboratory and California Institute of Technology, under contracts and cooperative agreements with the National Aeronautics and Space Administration.

  20. 110 kV双回线路管型复合材料杆避雷线架设与接地方案研究%Erection Scheme of Overhead Grounding Wire on Composite Material Pole and Its Grounding for 110 kV Double Circuit Overhead Transmission Lines

    Institute of Scientific and Technical Information of China (English)

    李志军; 陈维江; 戴敏; 李志政; 李汉明; 邓世聪

    2014-01-01

    我国学者尝试在雷电活动强烈、污秽严重地区的110 kV架空线路应用复合材料绝缘杆,以提高相对地空气间隙距离和爬电距离。然而绝缘水平的提高,复合材料杆还是否需要架设避雷线以及避雷线接地引下线,是防雷面临的关键技术问题之一。针对典型110 kV复合材料杆,对比研究未架设避雷线的复合材料杆与架设避雷线的同电压等级、相同导线高度铁塔线路的雷电性能,考虑2种杆塔线路引雷能力、雷电冲击绝缘强度以及建弧率等因素的差异,发现:2种杆塔线路引雷能力间的差异可以忽略;未架设避雷线的复合材料杆雷电冲击绝缘强度是铁塔的3.5倍,建弧率为铁塔的53%,但是反击耐雷水平仅为24.5 kA,雷击跳闸率高达1.13次/(100 km⋅a),均明显劣于铁塔。据此,推荐110 kV复合材料杆架设避雷线。然后,对比估算避雷线不同接地方案下雷电性能的差异发现:避雷线若不经引下线接地,则复合材料杆雷电性能明显劣于铁塔,但若经引下线逐杆接地,则雷电性能显著优于铁塔。因此,提出避雷线应逐杆接地。综上所述,110 kV 复合材料杆线路防雷接地方案应当采用架设避雷线,且通过金属引下线逐杆接地的设计。%It is attempted for Chinese scholars to apply insulation pole composed of composite material in the erection of 110 kV overhead transmission lines located at the regions with strong lightning activity and/or serious pollution to enhance the phase-to-ground air gap distance and creepage distance effectively. However, with the enhancement of insulation level whether the overhead ground wire should be erected on the composite material pole as well as its grounding downlead should be equipped are key problems that the lightning protection technology has to be faced with. As to the composite material pole for 110 kV transmission lines, the lightning

  1. Positive solubility of some classes of non-linear integral equations of Hammerstein type on the semi-axis and on the whole line

    Science.gov (United States)

    Khachatryan, Kh A.

    2015-04-01

    We study certain classes of non-linear Hammerstein integral equations on the semi-axis and the whole line. These classes of equations arise in the theory of radiative transfer in nuclear reactors, in the kinetic theory of gases, and for travelling waves in non-linear Richer competition systems. By combining special iteration methods with the methods of construction of invariant cone segments for the appropriate non-linear operator, we are able to prove constructive existence theorems for positive solutions in various function spaces. We give illustrative examples of equations satisfying all the hypotheses of our theorems.

  2. Diagnostics of the plasma parameters based on the K X-ray line positions for various 4d and 4f metals

    Directory of Open Access Journals (Sweden)

    Szymańska Ewa

    2016-12-01

    Full Text Available This paper shows the theoretical predictions of the outer-shell ionization effect on the positions of Kα1,2, Kβ1,3, and K β2 X-ray lines for some 4d-transition metals (molybdenum and palladium and 4f rare-earth elements (dysprosium and ytterbium. The ionization energy shifts have been evaluated using the multiconfiguration Dirac-Fock method, containing Breit interaction and quantum electrodynamic (QED corrections. The presented results are important for obtaining the information about some parameters of plasma generated by different sources, especially by pulsed power machine and short-pulse lasers.

  3. Level of suboptimal adherence to first line antiretroviral treatment & its determinants among HIV positive people in India

    Directory of Open Access Journals (Sweden)

    Beena Joshi

    2014-01-01

    Full Text Available Background & objectives: National Anti-retroviral treatment (ART programme in India was launched in 2004. Since then, there has been no published country representative estimate of suboptimal adherence among people living with HIV (PLHIV on first line ART in public settings. Hence a multicentric study was undertaken in 15 States of India to assess the level of suboptimal adherence and its determinants among PLHIV. Methods: Using a prospective observational study design, 3285 PLHIV were enrolled and followed up to six months across 30 ART centres in India. Adherence was assessed using pill count and self-reported recall method and determinants of suboptimal adherence were explored based on the responses to various issues as perceived by them. Results: Suboptimal adherence was found in 24.5 per cent PLHIV. Determinants of suboptimal adherence were illiteracy (OR-1.341, CI-1.080-1.665 , on ART for less than 6 months (OR-1.540, CI- 1.280-1.853, male gender (OR for females -0.807, CI- 0.662-0.982, tribals (OR-2.246, CI-1.134-4.447, on efavirenz (EFA regimen (OR- 1.479, CI - 1.190 - 1.837, presence of anxiety (OR- 1.375, CI - 1.117 - 1.692, non-disclosure of HIV status to family (OR- 1.549, CI - 1.176 - 2.039, not motivated for treatment (OR- 1.389, CI - 1.093 - 1.756, neglect from friends (OR-1.368, CI-1.069-1.751, frequent change of residence (OR- 3.373, CI - 2.659 - 4.278, travel expenses (OR- 1.364, CI - 1.138-1.649, not meeting the PLHIV volunteer/community care coordinator at the ART center (OR-1.639, CI-1.330-2.019. Interpretation & conclusions: To enhance identification of PLHIV vulnerable to suboptimal adherence, the existing checklist to identify the barriers to adherence in the National ART Guidelines needs to be updated based on the study findings. Quality of comprehensive adherence support services needs to be improved coupled with vigilant monitoring of adherence measurement.

  4. Functional Contributions of Positive Charges in the Pore-Lining Helix 3 of the Bordetella pertussis CyaA-Hemolysin to Hemolytic Activity and Ion-Channel Opening

    Directory of Open Access Journals (Sweden)

    Chattip Kurehong

    2017-03-01

    Full Text Available The Bordetella pertussis CyaA-hemolysin (CyaA-Hly domain was previously demonstrated to be an important determinant for hemolysis against target erythrocytes and ion-channel formation in planar lipid bilayers (PLBs. Here, net-charge variations in the pore-lining helix of thirteen related RTX cytolysins including CyaA-Hly were revealed by amino acid sequence alignments, reflecting their different degrees of hemolytic activity. To analyze possible functional effects of net-charge alterations on hemolytic activity and channel formation of CyaA-Hly, specific mutations were made at Gln574 or Glu581 in its pore-lining α3 of which both residues are highly conserved Lys in the three highly active RTX cytolysins (i.e., Escherichia coli α-hemolysin, Actinobacillus pleuropneumoniae toxin, and Aggregatibacter actinomycetemcomitans leukotoxin. All six constructed CyaA-Hly mutants that were over-expressed in E. coli as 126 kDa His-tagged soluble proteins were successfully purified via immobilized Ni2+-affinity chromatography. Both positive-charge substitutions (Q574K, Q574R, E581K, E581R and negative-charge elimination (E581Q appeared to increase the kinetics of toxin-induced hemolysis while the substitution with a negatively-charged side-chain (Q574E completely abolished its hemolytic activity. When incorporated into PLBs under symmetrical conditions (1.0 M KCl, pH 7.4, all five mutant toxins with the increased hemolytic activity produced clearly-resolved single channels with higher open probability and longer lifetime than the wild-type toxin, albeit with a half decrease in their maximum conductance. Molecular dynamics simulations for 50 ns of a trimeric CyaA-Hly pore model comprising three α2-loop-α3 transmembrane hairpins revealed a significant role of the positive charge at both target positions in the structural stability and enlarged diameter of the simulated pore. Altogether, our present data have disclosed functional contributions of positively

  5. Discovery and modelling of a flattening of the positive cyclotron line/luminosity relation in GX 304-1 with RXTE

    Science.gov (United States)

    Rothschild, Richard E.; Kühnel, Matthias; Pottschmidt, Katja; Hemphill, Paul; Postnov, Konstantin; Gornostaev, Mikhail; Shakura, Nikolai; Fürst, Felix; Wilms, Jörn; Staubert, Rüdiger; Klochkov, Dmitry

    2017-04-01

    The Rossi X-ray Timing Explorer (RXTE) observed four outbursts of the accreting X-ray binary transient source, GX 304-1 in 2010 and 2011. We present results of detailed 3-100 keV spectral analysis of 69 separate observations, and report a positive correlation between cyclotron line parameters, as well as other spectral parameters, with power-law flux. The cyclotron line energy, width and depth versus flux, and thus luminosity, correlations show a flattening of the relationships with increasing luminosity, which are well described by quasi-spherical or disc accretion that yield the surface magnetic field to be ∼5 × 1012 Gauss. Since HEXTE (High Energy X-ray Timing Experiment) cluster A was fixed aligned with the Proportional Counter Array field of view and cluster B was fixed viewing a background region 1.5° off of the source direction during these observations near the end of the RXTE mission, the cluster A background was estimated from cluster B events using HEXTEBACKEST. This made possible the detection of the ∼55 keV cyclotron line and an accurate measurement of the continuum. Correlations of all spectral parameters with the primary 2-10 keV power-law flux reveal it to be the primary driver of the spectral shape. The accretion is found to be in the collisionless shock braking regime.

  6. Line position analysis of the ν2 band of SO2F2 using the C2vTop Data System

    Science.gov (United States)

    Hmida, F.; Grouiez, B.; Rotger, M.; Faye, M.; Manceron, L.; Boudon, V.; Aroui, H.

    2016-07-01

    A new high-resolution infrared spectrum of the ν2 band of SO2F2 centered at 849.46 cm-1 has been recorded with a resolution of 0.00102 cm-1 at the AILES beamline of SOLEIL Synchrotron facility. More than 1600 lines up to Jmax = 41 have been assigned and fitted in line position using a tensorial formalism adapted to the case of XY2Z2 asymmetric molecules developed as an extension of the usual one used for spherical tops (Rotger et al., 2002). The analysis has been performed in the O (3) ⊃Td ⊃C2v group chain, thanks to the C2vTDS program suite (Wenger et al., 2005). This approach allows a systematic development of rovibrational interaction to study any polyad of SO2F2 and makes easier global analysis. Compared to a previous study (Merke et al., 2006), the present fit uses less effective Hamiltonian parameters but we assigned lines up to a lower J value.

  7. Discovery and Modeling of a Flattening of the Positive Cyclotron Line/Luminosity Relation in GX 304-1 with RXTE

    CERN Document Server

    Rothschild, Richard E; Pottschmidt, Katja; Hemphill, Paul; Postnov, Konstantin; Gornostaev, Mikhail; Shakura, Nikolai; Fuerst, Felix; Wilms, Joern; Staubert, Ruediger; Klochkov, Dmitry

    2016-01-01

    The RXTE observed four outbursts of the accreting X-ray binary transient source, GX 304-1 in 2010 and 2011. We present results of detailed 3-100 keV spectral analysis of 69 separate observations, and report a positive correlation between cyclotron line parameters, as well as other spectral parameters, with power law flux. The cyclotron line energy, width and depth versus flux, and thus luminosity, correlations show a flattening of the relationships with increasing luminosity, which are well described by quasi-spherical or disk accretion that yield the surface magnetic field to be ~60 keV. Since HEXTE cluster A was fixed aligned with the PCA field of view and cluster B was fixed viewing a background region 1.5 degrees off of the source direction during these observations near the end of the RXTE mission, the cluster A background was estimated from cluster B events using HEXTEBACKEST. This made possible the detection of the ~55 keV cyclotron line and an accurate measurement of the continuum. Correlations of all...

  8. Long-term use of first-line highly active antiretroviral therapy is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients

    Directory of Open Access Journals (Sweden)

    Haohui Zhu

    2014-09-01

    Full Text Available Objective: To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China. Method: Fifty human immunodeficiency virus-positive patients with at least a 5-year history of highly active antiretroviral therapy use and 50 human immunodeficiency virus-positive patients without a history of highly active antiretroviral therapy use were enrolled in this study. Carotid artery intima-media thickness and stiffness were determined by quantitative inter-media thickness and quantitative artery stiffness, respectively. Results: No statistically significant difference in carotid artery intima-media thickness and stiffness was observed between groups. A significant association between human immunodeficiency virus infection time and carotid artery stiffness was observed, but no significant association between human immunodeficiency virus infection time and intima-media thickness was found. No significant association between intima-media thickness, stiffness, and CD4+ and CD8+ T-cell counts were observed. Conclusion: The first-line highly active antiretroviral therapy currently used in China is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients with good highly active antiretroviral therapy compliance. Human immunodeficiency virus may play a role in the development of atherosclerosis.

  9. Pseudonegative BCL2 protein expression in a t(14;18) translocation positive lymphoma cell line: a need for an alternative BCL2 antibody.

    Science.gov (United States)

    Masir, Noraidah; Campbell, Lisa J; Jones, Margaret; Mason, David Y

    2010-04-01

    The t(14;18)(q32;q21) chromosomal translocation induces BCL2 protein expression in most follicular lymphomas. However, a small number of cases lack BCL2 expression despite carrying the t(14;18)(q32;q21) translocation. This study aims to explore the mechanism accounting for the lack of BCL2 protein expression when the t(14;18) translocation is present. BCL2 expression in the t(14;18) positive cell lines FL18, Karpas-422, SU-DHL-4 and SU-DHL-6, was analysed by Western blotting and by immunohistochemistry using two different antibodies. FISH analysis was performed to confirm the cytogenetic changes in the cell lines and real time quantitative PCR was used to evaluate the BCL2 mRNA level. Sequence analysis of translocated BCL2 was performed on FL18, Karpas-422, SU-DHL-4 and SU-DHL-6 cell lines. In FL18, Karpas-422, and SU-DHL-4, the BCL2 mRNA level correlated with the BCL2 protein expression. In contrast, BCL2 protein was not detected in SU-DHL-6 line using standard anti-BCL2 antibody (BCL2/124), despite the presence of the t(14;18) translocation and high level of mRNA. cDNA sequencing of translocated BCL2 showed three mutations in the SU-DHL-6 cell line, one of which resulted in an amino acid substitution (I48F) in the region recognised by the standard BCL2 antibody, whereas the other two were silent mutations at aa71 and aa72. Interestingly, when BCL2 expression was tested with an alternative antibody, E17, the protein was detected in SU-DHL-6, suggesting that the 'negativity' of SU-DHL-6 line for BCL2 using the standard antibody is spurious. Amino acid changes were found in Karpas-422 (G47D, P59L) and SU-DHL-4 (P59T, S117R) but these did not affect BCL2 detection. This study suggests that some somatic mutations of the translocated BCL2 gene may prevent epitope recognition by BCL2 antibodies, and hence cause false negative expression using the standard antibody. It is recommended that in practice all BCL2 negative cases should routinely be stained with an alternative

  10. FT-IR measurements of NH3 in the 1.5 μm region: line positions, intensities and their quantum assignments

    Science.gov (United States)

    Sung, K.; Brown, L. R.; Huang, X.; Schwenke, D. W.; Lee, T. J.

    2011-12-01

    As part of an effort to provide a complete set of spectroscopic line parameters of NH3 in the 1.5 μm region, we have analyzed the laboratory spectra recorded at various temperatures (200 - 299 K) with the McMath-Pierce Fourier transform spectrometer (FTS) on Kitt Peak Observatory in Arizona. The integrated sum of observed line strengths is measured to be 4.7×10-19 cm/molecule in the 6300 - 7000 cm-1 region. In this poster, we present line positions and strengths for the lines from four strong bands (2v1, 2v3, v1+v3, v1+2v4 and v3+2v4), which contribute more than 65% of opacity in the region. Lower state energies and quantum assignments determined by constructing combination differences are also presented. A theoretical IR linelist (X. Huang, D. W. Schwenke, and T. J. Lee. J. Chem. Phys., 134, 044320/044321, 2011) built upon the recent HSL-2 potential energy surface (nonadiabatic corrections included) is complementarily used for the quantum assignments. This work will support spectroscopic studies of atmospheres of outer planets, low mass brown dwarfs, and possibly extrasolar planets, in the 1.5 μm region (the H-band), where ammonia is one of significant opacity sources. (Research described in this talk was performed at Jet Propulsion Laboratory, California Institute of Technology, and was supported by the Planetary Atmospheric Research Program under the National Aeronautics and Space Administration. The AMES group acknowledges support from the NASA APRA & Herschel GO Program, and X.H. acknowledges the support by NASA/SETI Institute Co-operative Agreement.)

  11. The effects of nutrient losses from agriculture on ground and surface water quality: the position of science in developing indicators for regulation

    NARCIS (Netherlands)

    Schröder, J.J.; Scholefield, D.; Cabral, F.; Hofmans, G.

    2004-01-01

    The magnitude of current nutrient losses from agriculture to ground and surface water calls for effective environmental policy, including the use of regulation. Nutrient loss is experienced in many countries despite differences in the organisation and intensity of agricultural production. However, a

  12. Effect of herceptin combined with second-line therapy paclitaxel + S-1 on malignant degree and angiogenesis in patients with HER-2-positive gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Lei-Fan Li; Xiu-Yun Wang; Hui-Qiong Xu; Xia Liu

    2016-01-01

    Objective:To analyze the effect of herceptin combined with second-line therapy paclitaxel + S-1 on the malignant degree and angiogenesis in patients with HER-2-positive gastric cancer.Methods: A total of 90 patients with HER-2-positive gastric cancer were randomly divided into observation group and control group (n=45), control group received paclitaxel + S-1 chemotherapy, observation group received herceptin combined with paclitaxel + S-1 chemotherapy, and differences in the content of tumor markers and angiogenesis indexes in serum as well as mRNA expression levels of apoptosis and invasion genes in tumor biopsy specimens were compared between two groups of patients after 4 cycles of treatment.Results:CA19-9, CEA, CA242, CA724 and AFP content in serum of observation group were lower than those of control group; VEGF, bFGF, Ang-2 and IGF-Ⅱ content in serum were lower than those of control group while PEDF and ES content were higher than those of control group; apoptosis genesNorrin andp-Bad mRNA expression levels were lower than those of control group while BadandCaspase-3 mRNA expression levels were higher than those of control group; invasion genesEaf2 andE-cadherin mRNA expression levels were higher than those of control group while eIF4E, CD44, UHRF1 and Vav3mRNA expression levels were lower than those of control group.Conclusions:Herceptin combined with second-line therapy paclitaxel + S-1 can effectively inhibit the disease progression in patients with HER-2-positive gastric cancer, and is advantageous in reducing the malignant degree of tumor and prolonging patients’ survival time.

  13. Increased radiosensitivity of HPV-positive head and neck cancer cell lines due to cell cycle dysregulation and induction of apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Arenz, Andrea; Ziemann, Frank; Wittig, Andrea; Preising, Stefanie; Engenhart-Cabillic, Rita [Philipps-University, Department of Radiotherapy and Radiooncology, BMFZ - Biomedical Research Center, Marburg (Germany); Mayer, Christina; Wagner, Steffen; Klussmann, Jens-Peter; Wittekindt, Claus [Justus Liebig University, Department of Otorhinolaryngology and Head and Neck Surgery, Giessen (Germany); Dreffke, Kirstin [Philipps-University, Institute for Radiobiology and Molecular Radiooncology, Marburg (Germany)

    2014-09-15

    Human Papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) respond favourably to radiotherapy as compared to HPV-unrelated HNSCC. We investigated DNA damage response in HPV-positive and HPV-negative HNSCC cell lines aiming to identify mechanisms, which illustrate reasons for the increased sensitivity of HPV-positive cancers of the oropharynx. Radiation response including clonogenic survival, apoptosis, DNA double-strand break (DSB) repair, and cell cycle redistribution in four HPV-positive (UM-SCC-47, UM-SCC-104, 93-VU-147T, UPCI:SCC152) and four HPV-negative (UD-SCC-1, UM-SCC-6, UM-SCC-11b, UT-SCC-33) cell lines was evaluated. HPV-positive cells were more radiosensitive (mean SF2: 0.198 range: 0.22-0.18) than HPV-negative cells (mean SF2: 0.34, range: 0.45-0.27; p = 0.010). Irradiated HPV-positive cell lines progressed faster through S-phase showing a more distinct accumulation in G2/M. The abnormal cell cycle checkpoint activation was accompanied by a more pronounced increase of cell death after x-irradiation and a higher number of residual and unreleased DSBs. The enhanced responsiveness of HPV-related HNSCC to radiotherapy might be caused by a higher cellular radiosensitivity due to cell cycle dysregulation and impaired DNA DSB repair. (orig.) [German] Fuer Patienten mit HPV-assoziierten Kopf-Hals-Tumoren (HNSCC) ist im Vergleich zu Patienten mit nicht-HPV-assoziierten Tumoren ein besseres Ueberleben nach Radiotherapie gesichert. Ziel der Untersuchung war die Identifizierung von Unterschieden in der zellulaeren DNA-Schadensantwort von HPV-positiven und HPV-negativen Zelllinien, wodurch die bereits in Erprobung stehende Deeskalation einer Radiotherapie bei Patienten mit HPV-assoziierten HNSCC durch experimentelle Daten abgesichert werden koennte. Klonogenes Ueberleben, Induktion von Apoptose, DNA-Doppelstrang-Reparatur und Zellzyklusverhalten wurden in vier HPV-positiven (UM-SCC-47, UM-SCC-104, 93-VU-147T, UPCI:SCC152) und vier HPV

  14. SEISMIC RESPONSE OF LARGE CROSSING TRANSMISSION TOWER-LINE SYSTEM SUBJECTED TO NEAR-FAULT GROUND MOTIONS%大跨越输电塔-线体系的近场脉冲型地震反应分析

    Institute of Scientific and Technical Information of China (English)

    武钢; 翟长海; 李爽; 谢礼立

    2013-01-01

    分析了大跨越输电塔-线体系的动力特性,对比了大跨越输电塔-线体系的近-远场地震反应,研究了大跨越塔-线体系的近场脉冲地震反应规律.结果表明在同幅值的近场脉冲型地震动作用下,大跨越输电塔-线体系的动力反应远大于其在一般地震动下的反应,大跨越输电塔-线体系的近场脉冲型地震反应幅值随地震动脉冲周期增大而增大.将等效脉冲模型引入大跨越输电塔-线体系近场响应分析,结果表明:塔-线体系在等效脉冲作用下的响应与实际地震动相近,将等效脉冲用于分析大跨越输电塔-线体系的地震响应能够弥补实际近场脉冲型地震动数目过少的不足.%Dynamic characteristics of a large crossing transmission tower-line system (LCTTL) are analyzed.The seismic responses of a large crossing transmission tower-line system subjected to near-fault pulse-like ground motions and ordinary ground motions are compared.The characteristics of responses caused by near-fault pulse-like ground motions are presented.It is shown that the seismic responses of LCTL induced by near-fault pulse-like ground motions are severer than the responses subjected to ordinary ground motions.The amplitude of seismic responses increases with the pulse period of near-fault pulse-like ground motions.An equivalent pulse model is introduced to seismic response evaluation of LCTL.The results demonstrate that the equivalent pulse model can capture the important response characteristics of the near-fault records.The application of equivalent pulse model in seismic responses analysis of LCTL can augment the number of near-fault record set.

  15. A combination of positive dielectrophoresis driven on-line enrichment and aptamer-fluorescent silica nanoparticle label for rapid and sensitive detection of Staphylococcus aureus.

    Science.gov (United States)

    Shangguan, Jingfang; Li, Yuhong; He, Dinggeng; He, Xiaoxiao; Wang, Kemin; Zou, Zhen; Shi, Hui

    2015-07-07

    Staphylococcus aureus (S. aureus) is an important human pathogen that causes several diseases ranging from superficial skin infections to life-threatening diseases. Here, a method combining positive dielectrophoresis (pDEP) driven on-line enrichment and aptamer-fluorescent silica nanoparticle label has been developed for the rapid and sensitive detection of S. aureus in microfluidic channels. An aptamer, having high affinity to S. aureus, is used as the molecular recognition tool and immobilized onto chloropropyl functionalized fluorescent silica nanoparticles through a click chemistry approach to obtain S. aureus aptamer-nanoparticle bioconjugates (Apt(S.aureus)/FNPs). The pDEP driven on-line enrichment technology was used for accumulating the Apt(S.aureus)/FNP labeled S. aureus. After incubating with S. aureus, the mixture of Apt(S.aureus)/FNP labeled S. aureus and Apt(S.aureus)/FNPs was directly introduced into the pDEP-based microfluidic system. By applying an AC voltage in a pDEP frequency region, the Apt(S.aureus)/FNP labelled S. aureus moved to the electrodes and accumulated in the electrode gap, while the free Apt(S.aureus)/FNPs flowed away. The signal that came from the Apt(S.aureus)/FNP labelled S. aureus in the focused detection areas was then detected. Profiting from the specificity of aptamer, signal amplification of FNP label and pDEP on-line enrichment, this assay can detect as low as 93 and 270 cfu mL(-1)S. aureus in deionized water and spiked water samples, respectively, with higher sensitivities than our previously reported Apt(S.aureus)/FNP based flow cytometry. Moreover, without the need for separation and washing steps usually required for FNP label involved bioassays, the total assay time including sample pretreatment was within 2 h.

  16. A very low geno2pheno false positive rate is associated with poor viro-immunological response in drug-naive patients starting a first-line HAART.

    Directory of Open Access Journals (Sweden)

    Daniele Armenia

    Full Text Available We previously found that a very low geno2pheno false positive rate (FPR ≤ 2% defines a viral population associated with low CD4 cell count and the highest amount of X4-quasispecies. In this study, we aimed at evaluating whether FPR ≤ 2% might impact on the viro-immunological response in HIV-1 infected patients starting a first-line HAART.The analysis was performed on 305 HIV-1 B subtype infected drug-naïve patients who started their first-line HAART. Baseline FPR (% values were stratified according to the following ranges: ≤ 2; 2-5; 5-10; 10-20; 20-60; >60. The impact of genotypically-inferred tropism on the time to achieve immunological reconstitution (a CD4 cell count gain from HAART initiation ≥ 150 cells/mm(3 and on the time to achieve virological success (the first HIV-RNA measurement 60; p = 0.008. The overall proportion of patients achieving virological success was 95.5% by 12 months of therapy. Multivariable Cox analyses showed that patients having pre-HAART FPR ≤ 2% had a significant lower relative adjusted hazard [95% C.I.] both to achieve immunological reconstitution (0.37 [0.20-0.71], p = 0.003 and to achieve virological success (0.50 [0.26-0.94], p = 0.031 than those with pre-HAART FPR >60%.Beyond the genotypically-inferred tropism determination, FPR ≤ 2% predicts both a poor immunological reconstitution and a lower virological response in drug-naïve patients who started their first-line therapy. This parameter could be useful to identify patients potentially with less chance of achieving adequate immunological reconstitution and virological undetectability.

  17. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines

    Directory of Open Access Journals (Sweden)

    Cristiane Tavares

    2016-06-01

    Full Text Available ABSTRACT BACKGROUND: Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new drugs to treat myeloproliferative neoplasms, including l-amino acid oxidase from Calloselasma rhodostoma snake venom (CR-LAAO, which is a toxin capable of eliciting apoptosis in several tumor cell lines. OBJECTIVE: To evaluate the effects of l-amino acid oxidase from C. rhodostoma snake venom in the apoptotic machinery of JAK2-mutated cell lines. METHODS: The HEL 92.1.7 and SET-2 cell lines were cultured with l-amino acid oxidase and catalase for 12 h at 37 °C in 5% carbon dioxide. The cell viability was assessed by the multi-table tournament method, the level of apoptosis was measured by flow cytometry, and the expression of cysteine-dependent aspartate-specific proteases and cleaved Poly(ADP-ribose polymerase were analyzed by Western blotting. RESULTS: l-Amino acid oxidase from C. rhodostoma snake venom was cytotoxic to HEL 92.1.7 and SET-2 cells (50% inhibitory concentration = 0.15 µg/mL and 1.5 µg/mL, respectively and induced apoptosis in a concentration-dependent manner. Cell treatment with catalase mitigated the l-amino acid oxidase toxicity, indicating that hydrogen peroxide is a key component of its cytotoxic effect.The activated caspases 3 and 8 expression and cleaved PARP in HEL 92.1.7 and SET-2 cells confirmed the apoptosis activation by CR-LAAO. CONCLUSIONS: l-Amino acid oxidase from C. rhodostoma snake venom is a potential antineoplastic agent against HEL 92.1.7 and SET-2 JAK2V617F-positive cells as it activates the extrinsic apoptosis pathway.

  18. A Calculation Method of Grounding-Distance Protection Setting for Transmission Lines with Double-Branched Structure%双分叉线路的接地距离保护整定计算

    Institute of Scientific and Technical Information of China (English)

    文安; 王聪; 李建设; 于芮技; 莫天文; 魏承志; 寻斌斌; 李银红

    2014-01-01

    双分叉线路是输电线路增容改建工程中产生的一种特殊结构线路。可以增大线路输送容量,提高走廊利用率,并且节约建设投资,缩短工期,停电时间较短。从双分叉线路结构特点和保护原理入手,分析了双分叉结构对继电保护整定计算的影响。分析表明,对于双分叉线路,采用改建后线路的实际测量参数,或根据原线路参数计算得到的修正参数,及时调整零序补偿系数中的相应一次值,然后按简单线路整定方法进行整定即可,不会造成保护玉段超越误动。为继电保护整定计算工作提供了依据。%Double-branched transmission line is a special structure in the extension and reconstruction of transmission lines.It can be used to increase the capacity of transmission lines, improve transmission corridors' use efficiency, save cost, shorten construction pe-riod and outage time.A model for double-branched lines has been established based on its structure, and on this basis, effect of the double branched structure to selectivity of ground distance protection has been discussed.The analysis shows that, for transmission lines with double-branched structure, it only needs to calculate zero-sequence compensating coefficient with the correct actual meas-ured value of the newly structured lines or the adjusted parameters, that can get reasonable setting values in the light of the original setting calculation method for usual lines.It provides more reasonable principles when determining the grounding distance protection settings.

  19. Attenuation of ground-borne vibration affecting residents near railway. Lines Deliverable 2.1: Exposure response relationships and factors influencing these relationships (Work Package WP1)

    NARCIS (Netherlands)

    Janssen, S.A.; Vos, H.; Koopman, A.

    2014-01-01

    The objective of the present deliverable is to describe and assess reported health impacts of vibration among residents living near railway lines, in particular the response to freight trains. To this end, first a state of the art overview is given of the results from all field studies reported so f

  20. Simulation study for measurement of horizontal wind profiles in the polar stratosphere and mesosphere using ground-based observations of ozone and carbon monoxide lines in the 230-250 GHz region

    Science.gov (United States)

    Newnham, David A.; Ford, George P.; Moffat-Griffin, Tracy; Pumphrey, Hugh C.

    2016-07-01

    Meteorological and atmospheric models are being extended up to 80 km altitude but there are very few observing techniques that can measure stratospheric-mesospheric winds at altitudes between 20 and 80 km to verify model datasets. Here we demonstrate the feasibility of horizontal wind profile measurements using ground-based passive millimetre-wave spectroradiometric observations of ozone lines centred at 231.28, 249.79, and 249.96 GHz. Vertical profiles of horizontal winds are retrieved from forward and inverse modelling simulations of the line-of-sight Doppler-shifted atmospheric emission lines above Halley station (75°37' S, 26°14' W), Antarctica. For a radiometer with a system temperature of 1400 K and 30 kHz spectral resolution observing the ozone 231.28 GHz line we estimate that 12 h zonal and meridional wind profiles could be determined over the altitude range 25-74 km in winter, and 28-66 km in summer. Height-dependent measurement uncertainties are in the range 3-8 m s-1 and vertical resolution ˜ 8-16 km. Under optimum observing conditions at Halley a temporal resolution of 1.5 h for measuring either zonal or meridional winds is possible, reducing to 0.5 h for a radiometer with a 700 K system temperature. Combining observations of the 231.28 GHz ozone line and the 230.54 GHz carbon monoxide line gives additional altitude coverage at 85 ± 12 km. The effects of clear-sky seasonal mean winter/summer conditions, zenith angle of the received atmospheric emission, and spectrometer frequency resolution on the altitude coverage, measurement uncertainty, and height and time resolution of the retrieved wind profiles have been determined.

  1. Comparison of multi-pole shaping and delay line clipping pre-amplifiers for position sensitive NaI(Tl) detectors

    Energy Technology Data Exchange (ETDEWEB)

    Freifelder, R.; Karp, J.S.; Wear, J.A.; Lockyer, N.S.; Newcomer, F.M.; Surti, S.; Berg, R. van [Univ. of Pennsylvania, Philadelphia, PA (United States)

    1998-06-01

    NaI(Tl) position sensitive detectors have been used in medical imaging for many years. For PET applications without collimators, the high counting rates place severe demands on such large area detectors. The NaI(Tl) detectors in the PENN-PET scanners are read-out via photomultiplier tubes and preamplifiers. Those preamplifiers use a delay-line clipping technique to shorten the characteristic 240 ns fall time of the NaI(Tl) signal. As an alternative, the authors have investigated a pole-zero network to shorten the signal followed by a multi-pole shaper to produce a symmetric signal suitable for high counting rates. This has been compared to the current design by measuring the energy and spatial resolution of a single detector as a function of different preamplifier designs. Data were taken over a range of ADC integration times and countrates. The new design shows improved energy resolution with short integration times. Effects on spatial resolution and deadtime are reported for large position sensitive detectors at different countrates.

  2. 基于RAP的垂直线列阵时反定位研究%Research on time reversal positioning of vertical line array based on RAP

    Institute of Scientific and Technical Information of China (English)

    王鸿吉; 韩建辉; 杨日杰

    2015-01-01

    在分析可靠声路径( RAP )的物理机理的基础上,将RAP与时间反转处理相结合,研究了基于RAP的垂直水听器阵时反定位问题,并在Munk声速剖面下的进行了仿真分析,结果表明了利用RAP进行垂直线列阵时反定位的有效性,通过适当提高阵元数量和间距可增强时反聚焦效果。%On the basis of analyzing physical mechanism of reliable acoustic path( RAP ) and time reversal processing is combined. Time reversal positioning problem of vertical hydrophone array based on RAP is researched. Simulation analysis under the condition of Munk sound speed profile is carried out,and the result shows validity of positioning of vertical line array based on RAP,improving sensor number and distance between sensors can enhance time-reversal energy focus effect.

  3. Efficacy of Letrozole as First-Line Treatment of Postmenopausal Women with Hormone Receptor-Positive Metastatic Breast Cancer in Korea.

    Science.gov (United States)

    Beom, Seung Hoon; Oh, Jisu; Kim, Tae-Yong; Lee, Kyung-Hun; Yang, Yaewon; Suh, Koung Jin; Moon, Hyeong-Gon; Han, Sae-Won; Oh, Do-Youn; Han, Wonshik; Kim, Tae-You; Noh, Dong-Young; Im, Seock-Ah

    2017-04-01

    Letrozole showed efficacy and generally favorable toxicities, along with the convenience of oral administration in postmenopausal patients with hormone receptor (HR)-positive metastatic breast cancer (MBC). To the best of our knowledge, there have been no reports of the clinical outcomes in Korean patients, although letrozole is widely used in practice. Therefore, this studywas conducted to affirm the efficacy and toxicities of letrozole in Korean patients. This study retrospectively analyzed 84 HR-positive MBC patients who had been treated with letrozole from January 2001 to December 2012. Clinicopathological characteristics and treatment history were extracted from medicalrecords. All patients received 2.5 mg letrozole once a day until there were disease progressions or unacceptable toxicity. Progression-free survival (PFS) was the primary endpoint, and secondary endpoints were overall survival (OS), objective response rate (ORR), and toxicity. The median age of the subjects was 59.3 years. Letrozole treatment resulted in a median PFS of 16.8 months (95% confidence interval [CI], 9.8 to 23.8) and a median OS of 56.4 months (95% CI, 38.1 to 74.7). The ORR was 36.9% for the 84 patients with measurable lesions. Multivariate analysis revealed symptomatic visceral disease (hazard ratio, 3.437; 95% CI, 1.576 to 7.495; p=0.002) and a disease-free interval ≤ 2 years (hazard ratio, 2.697; 95% CI, 1.262 to 5.762; p=0.010) were independently associated with shorter PFS. However, sensitivity to adjuvant hormone treatment was not related to PFS. Letrozole was generally well tolerated. Letrozole showed considerable efficacy and tolerability as a first-line treatment in postmenopausal patients with HR-positive MBC.

  4. Antiproliferative activity and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cell lines by Gmelina asiatica roots

    Directory of Open Access Journals (Sweden)

    Madhu Katyayani Balijepalli

    2010-01-01

    Full Text Available Low risk of breast cancer has been proposed to be associated with high intake of lignans. We have reported the presence of lignans in Gmelina asiatica roots. There are no scientific reports on the antiproliferative activity of G. asiatica roots. The objective of the present study was to evaluate the effect of ethyl acetate extract from G. asiatica roots (EGAR on estrogen receptor-positive (MCF-7 and negative (MDA-MB-231 human breast cancer cell lines. The effects of 50% inhibitory concentrations (IC 50 of EGAR on MCF-7 and MDA-MB-231 cells were determined using 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide (MTT assay kit. The mode of cell death caused by EGAR was determined using dual apoptosis assay kit by observing the cells under fluorescent microscope. The quantification of apoptosis and necrosis in cells caused by EGAR was determined using cell death detection kit through ELISA. Down-regulation of the proliferative activity occurred in a clear dose-dependent response with IC 50 values of 32.9 ± 3.8 μg/mL in MCF-7 and 19.9 ± 2.3 μg/mL in MDA-MB-231 cell lines. Treatment of breast cancer cells with EGAR resulted in significant apoptosis. The EGAR contain lignans and flavonoids. The antiproliferative activity of the extract is attributed to the presence of these secondary metabolites. The results suggest the efficacy of G. asiatica roots as antiproliferative agents on human breast cancer cells, supporting the hypothesis that plants containing lignans have beneficial effects on human breast cancer.

  5. In-line positioning of ultrasound images using wireless remote display system with tablet computer facilitates ultrasound-guided radial artery catheterization.

    Science.gov (United States)

    Tsuchiya, Masahiko; Mizutani, Koh; Funai, Yusuke; Nakamoto, Tatsuo

    2016-02-01

    Ultrasound-guided procedures may be easier to perform when the operator's eye axis, needle puncture site, and ultrasound image display form a straight line in the puncture direction. However, such methods have not been well tested in clinical settings because that arrangement is often impossible due to limited space in the operating room. We developed a wireless remote display system for ultrasound devices using a tablet computer (iPad Mini), which allows easy display of images at nearly any location chosen by the operator. We hypothesized that the in-line layout of ultrasound images provided by this system would allow for secure and quick catheterization of the radial artery. We enrolled first-year medical interns (n = 20) who had no prior experience with ultrasound-guided radial artery catheterization to perform that using a short-axis out-of-plane approach with two different methods. With the conventional method, only the ultrasound machine placed at the side of the head of the patient across the targeted forearm was utilized. With the tablet method, the ultrasound images were displayed on an iPad Mini positioned on the arm in alignment with the operator's eye axis and needle puncture direction. The success rate and time required for catheterization were compared between the two methods. Success rate was significantly higher (100 vs. 70 %, P = 0.02) and catheterization time significantly shorter (28.5 ± 7.5 vs. 68.2 ± 14.3 s, P method as compared to the conventional method. An ergonomic straight arrangement of the image display is crucial for successful and quick completion of ultrasound-guided arterial catheterization. The present remote display system is a practical method for providing such an arrangement.

  6. Steps toward determination of the size and structure of the broad-line region in active galactic nuclei. 8: An intensive HST, IUE, and ground-based study of NGC 5548

    Science.gov (United States)

    Korista, K.; Alloin, D.; Barr, P.; Clavel, J.; Cohen, R. D.; Crenshaw, D. M.; Evans, I. N.; Horne, K.; Koratkar, A. P.; Kriss, G. A.

    1994-01-01

    We present the data and initial results from a combined HST/IUE/ground-based spectroscopic monitoring campaign on the Seyfert 1 galaxy NGC 5548 that was undertaken in order to address questions that require both higher temporal resolution and higher signal-to-noise ratios than were obtained in our previous multiwavelength monitoring of this galaxy in 1988-89. IUE spectra were obtained once every two days for a period of 74 days beginning on 14 March 1993. During the last 39 days of this campaign, spectroscopic observations were also made with the HST Faint Object Spectrograph (FOS) on a daily basis. Ground-based observations, consisting of 165 optical spectra and 77 photometric observations (both CCD imaging and aperture photometry), are reported for the period 1992 October to 1993 September, although much of the data are concentrated around the time of the satellite-based program. These data constitute a fifth year of intensive optical monitoring of this galaxy. In this contribution, we describe the acquisition and reduction of all of the satellite and ground-based data obtained in this program. We describe in detail various photometric problems with the FOS and explain how we identified and corrected for various anomalies. During the HST portion of the monitoring campaign, the 1350 A continuum flux is found to have varied by nearly a factor of two. In other wavebands, the continuum shows nearly identical behavior, except that the amplitude of variability is larger at shorter wavelengths, and the continuum light curves appear to show more short time-scale variability at shorter wavelengths. The broad emission lines also vary in flux, with amplitudes that are slightly smaller than the UV continuum variations and with a small time delay relative to the UV continuum. On the basis of simple time-series analysis of the UV and optical continuum and emission line light curves, we find (1) that the ultraviolet and optical continuum variations are virtually simultaneous

  7. 单档距走廊法架设高压输电线路对地闪的影响%The Influence on Ground Flash from the HV Transmission Lines Erected with Statistical Method of Single-span Corridor

    Institute of Scientific and Technical Information of China (English)

    黎志锋; 张耀宇; 刘刚; 唐军

    2011-01-01

    基于引雷空间理论及珠三角地区已有输电线路参数,建立了单档距走廊法统计模型,对不同地形环境下输电线路走廊区域的地闪定位数据进行了筛选,分析了输电线路架设前后雷电活动及地闪幅值概率分布规律,并基于有限元-模拟电荷法,对雷云先导与大地均匀静电场在置入输电杆塔前后的电场进行了计算及模拟仿真,分析了输电线路的架设时于地闪分布规律影响.结果表明:在不同地形环境下输电线路所产生的对于雷击落点的吸引效应是不同的,在山地环境下最为明显.%Based on the theory of attractive volume of lightning and the parameters of existing transmission lines of the Pearl River Delta region, the statistical method of single-span corridor is established in this paper. Selecting the lightning location data of the corridor area of transmission line in various terrain environments, the paper analyzes the probability distribution of lightning activity and lightning current amplitude before and after the erection of HV transmission lines, and makes calculation and simulation on the electrostatic fields of lightning leader and ground for the both cases based on finite element-charge simulation method to analyze the influence on ground flash from the HV transmission lines erected with statistical method of single-span corridor. The results show that the attractive effect from the transmission line is different in various terrain environments, and is greater in mountainous area.

  8. Grounded theory.

    Science.gov (United States)

    Harris, Tina

    2015-04-29

    Grounded theory is a popular research approach in health care and the social sciences. This article provides a description of grounded theory methodology and its key components, using examples from published studies to demonstrate practical application. It aims to demystify grounded theory for novice nurse researchers, by explaining what it is, when to use it, why they would want to use it and how to use it. It should enable nurse researchers to decide if grounded theory is an appropriate approach for their research, and to determine the quality of any grounded theory research they read.

  9. Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples.

    Science.gov (United States)

    Meaza, Abyot; Kebede, Abebaw; Yaregal, Zelalem; Dagne, Zekarias; Moga, Shewki; Yenew, Bazezew; Diriba, Getu; Molalign, Helina; Tadesse, Mengistu; Adisse, Desalegn; Getahun, Muluwork; Desta, Kassu

    2017-04-17

    Multi drug resistant tuberculosis (MDR-TB) poses formidable challenges to TB control due to its complex diagnostic and treatment challenges and often associated with a high rate of mortality. Accurate and rapid detection of MDR-TB is critical for timely initiation of treatment. Line Probe Assay (LPA) is a qualitative in vitro diagnostic test based on DNA-STRIP technology for the identification of the M. tuberculosis complex and its resistance to rifampicin (RMP) and/or isoniazid (INH). Hain Lifescience, GmbH, Germany has improved the sensitivity of Genotype MTBDRplus VER 2.0 LPA for the detection of MDR-TB; with the possibility of applying the tool in smear negative sputum samples. A cross sectional study was conducted on 274 presumptive MDR-TB patients referred to the National TB Reference Laboratory (NTRL), Ethiopian Public Health Institute (EPHI) who submitted sputum samples for laboratory diagnosis of drug resistant-TB testing. Seventy-two smear and culture positive samples processed in smear positive direct LPA category and 197 smear negative sputum samples were processed for direct LPA. Among the smear negative samples 145 (73.6%) were culture negative and 26 (13.2%) were culture positive. All specimens were processed using NALC-NaOH method and ZN smear microscopy done from sediments. Genotype MTBDRplus VER 2.0 done from processed sputum sediments and the result was compared against the reference, BACTEC MGIT 960 culture and DST. Sensitivity, specificity, PPV and NPV of Genotype MTBDRplus VER 2.0 assay was determined and P-value TB from direct smear positive sputum samples. The sensitivity, specificity, PPV and NPV of Genotype MTBDR plus VER 2.0 LPA were 77.8, 97.2, 82.4 and 97.2%, respectively, for the detection of M. tuberculosis from direct smear negative sputum samples. Fourteen (53.8%) samples had valid results with LPA among the 26 smear negative culture positive samples. The remaining 8 (30.8%) and 4 (15.4%) were invalid and negative with LPA

  10. Collision induced broadening of ν1 band and ground state spectral lines of sulfur dioxide perturbed by N2 and O2

    Science.gov (United States)

    Ceselin, Giorgia; Tasinato, Nicola; Puzzarini, Cristina; Charmet, Andrea Pietropolli; Stoppa, Paolo; Giorgianni, Santi

    2017-09-01

    To monitor the constituents and trace pollutants of Earth atmosphere and understand its evolution, accurate spectroscopic parameters are fundamental information. SO2 is produced by both natural and anthropogenic sources and it is one of the principal causes of acid rains as well as an important component of fine aerosol particles, once oxidized to sulfate. The present work aims at determining SO2 broadening parameters using N2 and O2 as atmospherically relevant damping gases. Measurements are carried out in the infrared (IR) and mm-/sub-mm wave regions, around 8.8 μm and in the 104 GHz-1.1 THz interval, respectively. IR ro-vibrational transitions are recorded by using a tunable diode laser spectrometer, whereas the microwave spectra are recorded by using a frequency-modulated millimeter-/submillimeter-wave spectrometer. SO2-N2 and SO2-O2 collisional cross sections are retrieved for several ν1 band ro-vibrational transitions of 32S16O2, for some transitions belonging to either ν1 + ν2 - ν2 of 32S16O2 or ν1 of 34S16O2 as well as for about 20 pure rotational transitions in the vibrational ground state of the main isotopic species. From N2- and O2- broadening coefficients the broadening parameters of SO2 in air are derived. The work is completed with the study of the dependence of foreign broadening coefficients on the rotational quantum numbers.

  11. Structure of the T cell receptor in a Ti alpha V beta 2, alpha V beta 8-positive T cell line

    DEFF Research Database (Denmark)

    Hou, X; Dietrich, J; Kuhlmann, J

    1994-01-01

    The T cell receptor (TcR) is composed of at least six different polypeptide chains consisting of the clonotypic Ti heterodimer (Ti alpha beta or Ti gamma delta) and the noncovalently associated CD3 chains (CD3 gamma delta epsilon zeta). The exact number of subunits constituting the TcR is still...... not known; however, it has been suggested that each TcR contains two Ti dimers. To gain insight into the structure of the TcR we constructed a Ti alpha V beta 2, alpha V beta 8-positive T cell line which expressed the endogenous human TiV beta 8 and the transfected mouse TiV beta 2 both in association...... with the endogenous Ti alpha and CD3 chains at the cell surface. Preclearing experiments with radioiodinated cell lysate prepared with digitonin lysis buffer demonstrated that depleting the lysate of Ti alpha V beta 8 by immunoprecipitation with anti V beta 8 monoclonal antibody (mAb) did not reduce the amount of Ti...

  12. Positive effects of organic farming on below-ground mutualists: large-scale comparison of mycorrhizal fungal communities in agricultural soils.

    Science.gov (United States)

    Verbruggen, Erik; Röling, Wilfred F M; Gamper, Hannes A; Kowalchuk, George A; Verhoef, Herman A; van der Heijden, Marcel G A

    2010-06-01

    *The impact of various agricultural practices on soil biodiversity and, in particular, on arbuscular mycorrhizal fungi (AMF), is still poorly understood, although AMF can provide benefit to plants and ecosystems. Here, we tested whether organic farming enhances AMF diversity and whether AMF communities from organically managed fields are more similar to those of species-rich grasslands or conventionally managed fields. *To address this issue, the AMF community composition was assessed in 26 arable fields (13 pairs of organically and conventionally managed fields) and five semi-natural grasslands, all on sandy soil. Terminal restriction fragment length polymorphism community fingerprinting was used to characterize AMF community composition. *The average number of AMF taxa was highest in grasslands (8.8), intermediate in organically managed fields (6.4) and significantly lower in conventionally managed fields (3.9). Moreover, AMF richness increased significantly with the time since conversion to organic agriculture. AMF communities of organically managed fields were also more similar to those of natural grasslands when compared with those under conventional management, and were less uniform than their conventional counterparts, as expressed by higher beta-diversity (between-site diversity). *We suggest that organic management in agro-ecosystems contributes to the restoration and maintenance of these important below-ground mutualists.

  13. 探地雷达法在水工输水隧洞衬砌混凝土检测中的应用%Application of ground-penetrating radar method in detection of lining concrete in hydraulic tunnel

    Institute of Scientific and Technical Information of China (English)

    汪魁峰

    2014-01-01

    The non-destructive test of concrete structure is the importent problem in civil engineering field and is regarded as the key to ensure safety and durability of large concrete construction .Based on the in-troduction of rule and method of non-destructive test on ground-penetrating radar , the paper took hydrau-lic tunnel lining concrete as the measured object , and applied ground-penetrating radar method to test and verify concrete thickness , internal rebar distribution and internal defect .Through the comparison between the detection results by ground-penetrating radar and that by drilling core ,it analyzed the precision and deviation of ground-penetrating radar method .The research shows the results of non-destructive test by ground-penetrating radar method are reliable and can meet the requirement of quality control in construc -tion of engineering , the application of non-destructive test in water conservancy engineering is feasible .%混凝土结构的无损检测是工程界普遍重视的问题,也是保证结构安全的关键。在介绍探地雷达法无损检测原理方法基础上,以水工输水隧洞衬砌混凝土为被测对象,应用探地雷达法对衬砌混凝土厚度、内置钢筋分布、内部缺陷等进行测试、标识,并与钻芯法取芯检测结果比较,分析探地雷达法无损检测数据的精确度和偏差程度。结果表明:探地雷达法无损检测结果可信度高,能满足工程建设质量控制的要求,其在水利工程无损检测的应用是可行的。

  14. Testing of SIR (a transformable robotic submarine) in Lake Tahoe for future deployment at West Antarctic Ice Sheet grounding lines of Siple Coast

    Science.gov (United States)

    Powell, R. D.; Scherer, R. P.; Griffiths, I.; Taylor, L.; Winans, J.; Mankoff, K. D.

    2011-12-01

    A remotely operated vehicle (ROV) has been custom-designed and built by DOER Marine to meet scientific requirements for exploring subglacial water cavities. This sub-ice rover (SIR) will explore and quantitatively document the grounding zone areas of the Ross Ice Shelf cavity using a 3km-long umbilical tether by deployment through an 800m-long ice borehole in a torpedo shape, which is also its default mode if operational failure occurs. Once in the ocean cavity it transforms via a diamond-shaped geometry into a rectangular form when all of its instruments come alive in its flight mode. Instrumentation includes 4 cameras (one forward-looking HD), a vertical scanning sonar (long-range imaging for spatial orientation and navigation), Doppler current meter (determine water current velocities), multi-beam sonar (image and swath map bottom topography), sub-bottom profiler (profile sub-sea-floor sediment for geological history), CTD (determine salinity, temperature and depth), DO meter (determine dissolved oxygen content in water), transmissometer (determine suspended particulate concentrations in water), laser particle-size analyzer (determine sizes of particles in water), triple laser-beams (determine size and volume of objects), thermistor probe (measure in situ temperatures of ice and sediment), shear vane probe (determine in situ strength of sediment), manipulator arm (deploy instrumentation packages, collect samples), shallow ice corer (collect ice samples and glacial debris), water sampler (determine sea water/freshwater composition, calibrate real-time sensors, sample microbes), shallow sediment corer (sample sea floor, in-ice and subglacial sediment for stratigraphy, facies, particle size, composition, structure, fabric, microbes). A sophisticated array of data handling, storing and displaying will allow real-time observations and environmental assessments to be made. This robotic submarine and other instruments will be tested in Lake Tahoe in September, 2011 and

  15. 大庆地区地面变形对哈齐客专的影响研究%Study on Influence of Ground Deformation in Daqing Region on Harbin-Qiqihaer Passenger Dedicated Line

    Institute of Scientific and Technical Information of China (English)

    甄庆廷

    2013-01-01

    研究目的:哈尔滨至齐齐哈尔客运专线穿过的大庆油田由于高强度注水采油和工业、生活超量开采地下水,致使在油田采区及地下水下降漏斗区产生了不同程度的地面隆起和沉降变形,不均匀地面变形会对高速行驶的列车安全产生一定程度的影响,因此,查明和研究地面变形发生的范围、速率、变形量及对客运专线的影响程度,为设计采取必要的措施提供依据是非常必要的.研究结论:(1)为准确了解大庆地区地面变形规律,应建立地面变形动态监测系统,监测第四系沉降变形和白垩系隆起变形特征.(2)多采用化学驱油方式,控制注水压力,尽量保持压力场的平衡,并对靠近线路的采油井和注水井进行适当迁改.(3)在动态监测的基础上,建立地下水开采、采油注水、地面变形的耦合模型,预测地面变形发生、发展趋势,为铁路工程提供准确的预报预警.通过分析得出随着采油工艺的改进、地下水减采和动态监测系统的建立,大庆地区地面变形会得到有效控制和缓解,不会对哈齐客运专线工程造成较大影响.%Research purposes: The Harbin - Qiqihaer Passenger Dedicated Line passes through the Daqing oilfield in where the ground rises or settles in the oil extraction area and the underground water dropping area because of the high -pressure waterflooding for oil extraction and the over exploitation of groundwater for production and living. The uneven ground deformation maybe influences the safety of high -speed railway. Thus, it is necessary to find out and study the range, speed and deformation volume of the ground deformation and their influence on the passenger dedicated line for providing the reference to the railway design. Research conclusions: (1) For accurately knowing the regulation of the ground deformation of the Daqing area, the dynamic monitoring system for the ground deformation should be established to monitor

  16. Grounded cognition.

    Science.gov (United States)

    Barsalou, Lawrence W

    2008-01-01

    Grounded cognition rejects traditional views that cognition is computation on amodal symbols in a modular system, independent of the brain's modal systems for perception, action, and introspection. Instead, grounded cognition proposes that modal simulations, bodily states, and situated action underlie cognition. Accumulating behavioral and neural evidence supporting this view is reviewed from research on perception, memory, knowledge, language, thought, social cognition, and development. Theories of grounded cognition are also reviewed, as are origins of the area and common misperceptions of it. Theoretical, empirical, and methodological issues are raised whose future treatment is likely to affect the growth and impact of grounded cognition.

  17. Localizing Ground-Penetrating Radar

    Science.gov (United States)

    2014-11-01

    ing Ground-Penetrating Radar (LGPR) uses very high frequency (VHF) radar reflections of underground features to generate base- line maps and then...Innovative ground- penetrating radar that maps underground geological features provides autonomous vehicles with real-time localization. Localizing...NOV 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Localizing Ground-Penetrating Radar 5a. CONTRACT NUMBER

  18. Ground Attenuation of Railroad Noise

    DEFF Research Database (Denmark)

    Makarewicz, R.; Rasmussen, Karsten Bo; Kokowski, P.

    1996-01-01

    The influence of ground effect on railroad noise is described using the concept of the peak A-weighted sound exposure level, and A-weighted sound exposure level. The train is modelled by a continuous line of incoherent point sources that have a cosine directivity. The ground effect is included by...

  19. Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.

    Science.gov (United States)

    McLaughlin, Richard N; Young, Janet M; Yang, Lei; Neme, Rafik; Wichman, Holly A; Malik, Harmit S

    2014-09-01

    Mammalian genomes comprise many active and fossilized retroelements. The obligate requirement for retroelement integration affords host genomes an opportunity to 'domesticate' retroelement genes for their own purpose, leading to important innovations in genome defense and placentation. While many such exaptations involve retroviruses, the L1TD1 gene is the only known domesticated gene whose protein-coding sequence is almost entirely derived from a LINE-1 (L1) retroelement. Human L1TD1 has been shown to play an important role in pluripotency maintenance. To investigate how this role was acquired, we traced the origin and evolution of L1TD1. We find that L1TD1 originated in the common ancestor of eutherian mammals, but was lost or pseudogenized multiple times during mammalian evolution. We also find that L1TD1 has evolved under positive selection during primate and mouse evolution, and that one prosimian L1TD1 has 'replenished' itself with a more recent L1 ORF1 from the prosimian genome. These data suggest that L1TD1 has been recurrently selected for functional novelty, perhaps for a role in genome defense. L1TD1 loss is associated with L1 extinction in several megabat lineages, but not in sigmodontine rodents. We hypothesize that L1TD1 could have originally evolved for genome defense against L1 elements. Later, L1TD1 may have become incorporated into pluripotency maintenance in some lineages. Our study highlights the role of retroelement gene domestication in fundamental aspects of mammalian biology, and that such domesticated genes can adopt different functions in different lineages.

  20. Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).

    Science.gov (United States)

    Ottmann, Oliver G; Wassmann, Barbara; Pfeifer, Heike; Giagounidis, Aristoteles; Stelljes, Matthias; Dührsen, Ulrich; Schmalzing, Marc; Wunderle, Lydia; Binckebanck, Anja; Hoelzer, Dieter

    2007-05-15

    Elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) have a poor prognosis, with a low complete remission (CR) rate, high induction mortality, and short remission duration. Imatinib (IM) has a favorable toxicity profile but limited antileukemic activity in advanced Ph+ALL. Imatinib in combination with intensive chemotherapy has yielded promising results as front-line therapy, but its value as monotherapy in newly diagnosed Ph+ALL is not known. Patients with de novo Ph+ALL were randomly assigned to induction therapy with either imatinib (Ind(IM)) or multiagent, age-adapted chemotherapy (Ind(chemo)). Imatinib was subsequently coadministered with consolidation chemotherapy. In all, 55 patients (median age, 68 years) were enrolled. The overall CR rate was 96.3% in patients randomly assigned to Ind(IM) and 50% in patients allocated to Ind(chemo) (P = .0001). Nine patients (34.6%) were refractory and 2 patients died during Ind(chemo); none failed imatinib induction. Severe adverse events were significantly more frequent during Ind(chemo) (90% vs 39%; P = .005). The estimated overall survival (OS) of all patients was 42% +/- 8% at 24 months, with no significant difference between the 2 cohorts. Median disease-free survival was significantly longer in the 43% of patients (21 of 49 evaluable) in whom BCR-ABL transcripts became undetectable (18.3 months vs 7.2 months; P = .002). In elderly patients with de novo Ph+ALL, imatinib induction results in a significantly higher CR rate and lower toxicity than induction chemotherapy. With subsequent combined imatinib and chemotherapy consolidation, this initial benefit does not translate into improved survival compared with chemotherapy induction. (c) 2007 American Cancer Society

  1. Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.

    Directory of Open Access Journals (Sweden)

    Richard N McLaughlin

    2014-09-01

    Full Text Available Mammalian genomes comprise many active and fossilized retroelements. The obligate requirement for retroelement integration affords host genomes an opportunity to 'domesticate' retroelement genes for their own purpose, leading to important innovations in genome defense and placentation. While many such exaptations involve retroviruses, the L1TD1 gene is the only known domesticated gene whose protein-coding sequence is almost entirely derived from a LINE-1 (L1 retroelement. Human L1TD1 has been shown to play an important role in pluripotency maintenance. To investigate how this role was acquired, we traced the origin and evolution of L1TD1. We find that L1TD1 originated in the common ancestor of eutherian mammals, but was lost or pseudogenized multiple times during mammalian evolution. We also find that L1TD1 has evolved under positive selection during primate and mouse evolution, and that one prosimian L1TD1 has 'replenished' itself with a more recent L1 ORF1 from the prosimian genome. These data suggest that L1TD1 has been recurrently selected for functional novelty, perhaps for a role in genome defense. L1TD1 loss is associated with L1 extinction in several megabat lineages, but not in sigmodontine rodents. We hypothesize that L1TD1 could have originally evolved for genome defense against L1 elements. Later, L1TD1 may have become incorporated into pluripotency maintenance in some lineages. Our study highlights the role of retroelement gene domestication in fundamental aspects of mammalian biology, and that such domesticated genes can adopt different functions in different lineages.

  2. Development and Application of A New Type of Grounding Clamper for Transmission Lines%输电线路新型接地线夹的研制和应用

    Institute of Scientific and Technical Information of China (English)

    洪行军; 方玉群; 赵俊杰

    2015-01-01

    针对高压输电线路检修中存在的接地线导线夹挂设不便、易意外脱落等问题,从结构上进行创新,设计出新型接地线导线夹并简要介绍其结构和使用方法。型式检验和现场试用表明,该导线夹具有挂设简便快速、意外脱落率低、安全可靠等优点,效果显著,具有良好的应用前景。%According to the defect of current ground clamper for high voltage transmission lines such as hook inconvenience and accidental shedding, this paper designs a new type of wire clamper for transmission lines and introduces the structure and application method. Type test and field test show that this clamper is simple and rapid in hooking, low in accidental shedding, safe and reliable, significantly effective and has a good application prospect.

  3. Characterized Fault Model of Scenario Earthquake Caused by the Itoigawa-Shizuoka Tectonic Line Fault Zone in Central Japan and Strong Ground Motion Prediction

    Science.gov (United States)

    Sato, T.; Dan, K.; Irikura, K.; Furumura, M.

    2001-12-01

    Based on the existing ideas on characterizing complex fault rupture process, we constructed four different characterized fault models for predicting strong motions from the most likely scenario earthquake along the active fault zone of the Itoigawa-Shizuoka Tectonic Line in central Japan. The Headquarters for Earthquake Research Promotion in Japanese government (2001) estimated that the earthquake (8 +/- 0.5) has the total fault length of 112 km with four segments. We assumed that the characterized fault model consisted of two regions: asperity and background (Somerville et al., 1999; Irikura, 2000; Dan et al., 2000). The main differences in the four fault models were 1) how to determine a seismic moment Mo from a fault rupture area S, 2) number of asperities N, 3) how to determine a stress parameter σ , and 4) fmax. We calculated broadband strong motions at three stations near the fault by a hybrid method of the semi-empirical and theoretical approaches. A comparison between the results from the hybrid method and those from empirical attenuation relations showed that the hybrid method using the characterized fault model could evaluate near-fault rupture directivity effects more reliably than the empirical attenuation relations. We also discussed the characterized fault models and the strong motion characteristics. The Mo extrapolated from the empirical Mo-S relation by Somerville et al. (1999) was a half of that determined from the mean value of the Wells and Coppersmith (1994) data. The latter Mo was consistent with that for the 1891 Nobi, Japan, earthquake whose fault length was almost the same as the length of the target earthquake. In addition, the fault model using the latter Mo produced a slip amount of about 6 m on the largest asperity, which was consistent with the displacement of 6 m to 9 m per event obtained from a trench survey. High-frequency strong motions were greatly influenced by the σ for the asperities (188 bars, 246 bars, 108 bars, and 134

  4. Costs of adverse events associated with erlotinib or afatinib in first-line treatment of advanced EGFR-positive non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Isla D

    2016-12-01

    342.57–881.29 per patient.Conclusion: In advanced EGFR mutation-positive NSCLC patients, first-line treatment with erlotinib could reduce health care costs for the NHS, due to a decrease in the AE rate compared with afatinib. In long-term treatments, the avoidance of complications and the lowering of costs associated with the management of AEs are relevant factors that contribute to the sustainability of the health system. Keywords: adverse event, afatinib, cost analysis, erlotinib, non-small cell lung cancer

  5. Costs of adverse events associated with erlotinib or afatinib in first-line treatment of advanced EGFR-positive non-small cell lung cancer

    Science.gov (United States)

    Isla, Dolores; De Castro, Javier; Juan, Oscar; Grau, Santiago; Orofino, Javier; Gordo, Rocío; Rubio-Terrés, Carlos; Rubio-Rodríguez, Darío

    2017-01-01

    Objectives Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKIs) are an established treatment for advanced non-small cell lung cancer (NSCLC) with EGFR mutation. According to published meta-analyses, no significant efficacy differences have been demonstrated between erlotinib and afatinib. However, the incidence of EGFR–TKI-related adverse events (AEs) was lower with erlotinib. This study compares the cost of management of the AEs associated with these two drugs from the perspective of the Spanish National Health System (NHS). Methods The frequency of AEs was established from a recently published meta-analysis. In Spain, the daily cost of both drugs can be considered similar; as a result, only the costs of management of the AEs were considered. Costs and resource utilization in the management of the AEs were estimated by a panel of Spanish oncologists and from studies previously carried out in Spain. A probabilistic analysis was performed based on a Monte Carlo simulation. Results The model generated 1,000 simulations. The total cost per patient treated with erlotinib and afatinib was €657.44 and €1,272.15, respectively. With erlotinib, the cost per patient and per AE of grades ≤2 and ≥3 was €550.86 and €106.58, respectively, whereas the cost with afatinib was €980.63 and €291.52, respectively. The reduction in the number of AEs with erlotinib could avoid a mean cost for the NHS of €614.71 (95% CI: €342.57–881.29) per patient. Conclusion In advanced EGFR mutation-positive NSCLC patients, first-line treatment with erlotinib could reduce health care costs for the NHS, due to a decrease in the AE rate compared with afatinib. In long-term treatments, the avoidance of complications and the lowering of costs associated with the management of AEs are relevant factors that contribute to the sustainability of the health system. PMID:28115857

  6. Role of the STAT3/survivin signaling pathway in the EML4-ALK-positive lung adenocarcinoma cell line H2228 before and after crizotinib-induced resistance

    Institute of Scientific and Technical Information of China (English)

    Haiyan Peng; Wenhua Zhao Co-first author; Cuiyun Su; Xiangqun Song; Aiping Zeng; Huilin Wang; Ruiling Ning; Shaozhang Zhou 

    2015-01-01

    Objective This study investigated the role of the STAT3/survivin signaling pathway in the EML4-ALK–positive lung adenocarcinoma cel line H2228 before and after crizotinib-induced resistance. The mecha-nism of resistance was studied. Methods Cel viability was determined using the MTT assay. Crizotinib-induced apoptosis in H2228 and H2228 crizotinib-resistant cel s treated with the indicated doses of crizotinib was measured at dif erent times (24 h, 48 h, 72 h) using flow cytometry. The levels of p-ALK, ALK, p-STAT3, STAT3, and survivin after treatment of cel s with 0, 0.3, and 1μM crizotinib for 72 h were determined using Western blot analysis. DNA sequencing was used to identify mutations in H2228 crizotinib-resistant cel s. Results The crizotinib IC50 values in H2228 and H2228 crizotinib-resistant cel s at 72 h were 334.5 nM and 3418 nM, respectively. The resistance index of H2228 crizotinib-resistant cel s was 10.20. Crizotinib induced apoptosis in H2228 cel s and reduced the levels of p-ALK, p-STAT3, and survivin. In contrast, no changes in the levels of p-ALK, p-STAT3, and survivin were observed in H2228 crizotinib-resistant cel s. The mutations 2067G→A and 2182G→C in EML4-ALK were present in the H2228 crizotinib-resistant cel s. Conclusion Crizotinib decreased the viability of H2228 cel s in a dose- and time-dependent manner. In the STAT3/survivin pathway, downregulation of p-ALK, p-STAT3, and survivin might contribute to crizo-tinib-induced apoptosis in H2228 cel s. However, the STAT3/survivin pathway in H2228 crizotinib-resistant cel s was unaf ected by crizotinib treatment. Acquired resistance in H2228 cel s might be related to ALK mutations.

  7. A comparative study of protein patterns of human estrogen receptor positive (MCF-7) and negative (MDA-MB-231) breast cancer cell lines.

    Science.gov (United States)

    Flodrova, Dana; Toporova, Lucia; Macejova, Dana; Lastovickova, Marketa; Brtko, Julius; Bobalova, Janette

    2016-07-01

    In the present study, we analyzed the cell lysates of human tumour cell lines representing two major clinically different types of breast cancer. Our main goal was to show the differences between them on proteomic level. Gel electrophoresis followed by MALDI-TOF MS analysis was used for proteins determination. Exactly 98 proteins were unequivocally identified and 60 of them were expressed differentially between MDA-MB-231 and MCF-7 cell lines. Among the proteins reported here, some well-known breast cancer markers (e.g., annexin A1, annexin A2 and vimentin) were identified in the MDA-MB-231 cell line and thus we were able to distinguish both cell lines sufficiently.

  8. Ground Wars

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    Political campaigns today are won or lost in the so-called ground war--the strategic deployment of teams of staffers, volunteers, and paid part-timers who work the phones and canvass block by block, house by house, voter by voter. Ground Wars provides an in-depth ethnographic portrait of two...... infrastructures that utilize large databases with detailed individual-level information for targeting voters, and armies of dedicated volunteers and paid part-timers. Nielsen challenges the notion that political communication in America must be tightly scripted, controlled, and conducted by a select coterie...... of professionals. Yet he also quashes the romantic idea that canvassing is a purer form of grassroots politics. In today's political ground wars, Nielsen demonstrates, even the most ordinary-seeming volunteer knocking at your door is backed up by high-tech targeting technologies and party expertise. Ground Wars...

  9. 7 CFR 1755.402 - Ground resistance measurements.

    Science.gov (United States)

    2010-01-01

    ... ground resistance of electronic equipment such as span line repeaters, carrier terminal equipment... Protection Grounding Fundamentals,” for a comprehensive discussion of ground resistance measurements. (d... electronic equipment, the ground resistance shall not exceed 25 ohms. Where the measured ground...

  10. 交流线路与+800 kV直流线路同走廊时的地面混合电场研究%Study on the Hybrid Electric Field Over the Ground Surface Under AC Lines and ±800 kV DC Lines in the Same Corridor

    Institute of Scientific and Technical Information of China (English)

    杨勇; 陆家榆; 鞠勇

    2009-01-01

    交流线路与±800 kV直流线路共用走廊的情况将在我困出现,因此需要研究该种线路地面混合电场的计算方法,以满足工程设计和环境保护需要.在分析同走廊架设的交流线路与±800 kV直流线路相互影响的基础上,提出了一种计算该类线路地面混合电场的方法.通过对比使用该方法得到的计算结果与不考虑两种线路相互影响时的计算结果,得到如下结论:相对于忽略交直流线路的相互影响,当考虑其相互影响时,在同走廊交直流线路中心附近,地面混合电场的瞬时最大值横向分布有波动;两种计算方法得到的地面混合电场有效值分布曲线基本重合;在一个交流周期内,同走廊线路地面混合电场的最大值与单独±800 kV直流线路地面合成电场的最大值差别很小.%Parallel adjacent erection of AC transmission lines and ±800 kV DC transmission lines in the same corridor will occur in China, so the calculation method for the hybrid electric field over the ground under this type of lines should be studied so as to satisfy the requirements of engineering design and environmental protection. Based on the analysis of mutual influences between AC transmission lines and ±800 kV DC transmission lines in the same corridor, a calculation method is proposed. Through the comparison between the calculation results achieved with this method and the corresponding calculation results obtained when the mutual influences between AC transmission lines and ±800 kV DC transmission lines are neglected, some conclusions can be drawn as follows: compared with the calculation results obtained when the mutual influences are neglected, near the center of AC transmission lines and ±800 kV DC transmission lines in the same corridor, the lateral distribution of the instantaneous maximal values of the hybrid electric field obtained with the proposed method fluctuates;the lateral distributions of the virtual values of the

  11. 无人机地面目标定位精度蒙特卡罗仿真分析%Monte-CarloSimulation Analysis for UAV Ground Target Position Accuracy

    Institute of Scientific and Technical Information of China (English)

    李大健; 齐敏

    2011-01-01

    研究无人机定位准确性,针对定位系统模型误差问题,为了给无人侦察机地面目标定位系统的设计提供指导和依据,利用光电任务设备进行地面目标定位的数学模型和误差模型,对影响地面目标定位精度的误差因素进行了介绍,并利用蒙特卡罗分析方法对目标定位精度进行数学仿真,计算确定了影响系统定位精度的主要因素,指导系统精度指标进行更加合理的分配.验证结果,设计的系统满足大系统精度指标要求,并且避免了不必要的部件精度浪费,同时也证明了精度解决方法的有效和实用,可为定位系统设计提供了可靠依据.%In order to provide design basis for ground target position system of reconnaissance UAV, the mathematical model and error model of target position using electro-optical payload are derived. The error elements which influence the target position accuracy are introduced and the target position accuracy is simulated using Monte-Carlo analysis. The main error elements are also analyzed and the result helps a more reasonable system error allocation.Testing result of target position system designed on the accuracy analysis fully meets the system accuracy, avoids unnecessary component accuracy requirement, and saves the system cost. The application also proves the validity of Monte-Carlo simulation analysis for target position system.

  12. Epstein on Anchors and Grounds

    Directory of Open Access Journals (Sweden)

    Guala Francesco

    2016-03-01

    Full Text Available The distinction between anchors and grounds is one of the most innovative contributions of The Ant Trap. In this commentary I will argue that the distinction suffers from an ambiguity between tokens and types. This leads Epstein to endorse pluralism about anchors and grounds, a position that is not justified in the book and to which there are plausible alternatives.

  13. Sex differences in mental rotation and line angle judgments are positively associated with gender equality and economic development across 53 nations.

    Science.gov (United States)

    Lippa, Richard A; Collaer, Marcia L; Peters, Michael

    2010-08-01

    Mental rotation and line angle judgment performance were assessed in more than 90,000 women and 111,000 men from 53 nations. In all nations, men's mean performance exceeded women's on these two visuospatial tasks. Gender equality (as assessed by United Nations indices) and economic development (as assessed by per capita income and life expectancy) were significantly associated, across nations, with larger sex differences, contrary to the predictions of social role theory. For both men and women, across nations, gender equality and economic development were significantly associated with better performance on the two visuospatial tasks. However, these associations were stronger for the mental rotation task than for the line angle judgment task, and they were stronger for men than for women. Results were discussed in terms of evolutionary, social role, and stereotype threat theories of sex differences.

  14. Biomarker screening of oral cancer cell lines revealed sub-populations of CD133-, CD44-, CD24- and ALDH1- positive cancer stem cells

    Directory of Open Access Journals (Sweden)

    Kendall K

    2013-05-01

    Full Text Available Head and neck squamous cell carcinoma (HNSCC ranks sixth worldwide for cancer-related mortality. For the past several decades the mainstay of treatment for HNSCC has been surgery and external beam radiation, although more recent trials combining chemotherapy and radiation have demonstrated improvements. However, cancer recurrence and treatment failures continue to occur in a significant percentage of patients. Recent advances in tumor biology have led to the discovery that many cancers, including HNSCC, may contain subpopulations of cells with stem cell-like properties that may explain relapse and recurrence. The objective of this study was to screen existing oral cancer cell lines for biomarkers specific for cells with stem cell-like properties. RNA was isolated for RT-PCR screening using primers for specific mRNA of the biomarkers: CD44, CD24, CD133, NANOG, Nestin, ALDH1, and ABCG2 in CAL27, SCC25 and SCC15 cells. This analysis revealed that some oral cancer cell lines (CAL27 and SCC25 may contain small subpopulations of adhesion- and contact-independent cells (AiDC that also express tumor stem cell markers, including CD44, CD133, and CD24. In addition, CAL27 cells also expressed the intracellular tumor stem cell markers, ALDH1 and ABCG2. Isolation and culture of the adhesion- and contact-independent cells from CAL27 and SCC25 populations revealed differential proliferation rates and more robust inhibition by the MEK inhibitor PD98059, as well as the chemotherapeutic agents Cisplatin and Paclitaxel, within the AiDC CAL27 cells. At least one oral cancer cell line (CAL27 contained subpopulations of cells that express specific biomarkers associated with tumor stem cells which were morphologically and phenotypically distinct from other cells within this cell line.

  15. Positive correlation between the efficiency of induced pluripotent stem cells and the development rate of nuclear transfer embryos when the same porcine embryonic fibroblast lines are used as donor cells.

    Science.gov (United States)

    Xie, Bingteng; Wang, Jianyu; Liu, Shichao; Wang, Jiaqiang; Xue, Binghua; Li, Jingyu; Wei, Renyue; Zhao, Yanhua; Liu, Zhonghua

    2014-06-01

    Induced pluripotent stem cells (iPSCs) and nuclear transfer (NT) are two of the primary routes to reprogram differentiated cells back to the pluripotent state. However, it is still unknown whether there is any correlation between the reprogramming efficiency of iPSCs and NT if the same donor cells are employed. In this study, six porcine embryonic fibroblast (PEF) lines from Landrace (L1, L6, L9) or Congjiang local pigs (C4, C5, C6) were used for iPSC induction and NT. Furthermore, the resultant iPSCs from four PEF lines (L1, L6, C4, and C5) were used for NT (iPSC-NT), and the expression of exogenous genes was detected in iPSC-NT embryos by real-time PCR. The results showed that the efficiency of iPSC lines established from different PEF lines were significantly different. When the same PEF lines were used as donor cells for NT, the blastocysts rates were also different among different PEF lines and positively related with iPSCs induction efficiency. When the iPSCs were used as donor cells for NT, compared with the source PEFs, the blastocysts rates were significantly decreased. Real-time PCR results indicated that exogenous genes (Oct4, c-Myc) continued to be expressed in iPSC-NT embryos. In summary, our results demonstrate that there was a positive correlation between iPSCs and NT reprogramming efficiency, although the mechanism of these two routes is different. This may provide a new method to select the appropriate donor cells for inducing iPSCs.

  16. 客运专线铁路与普通铁路地面信号显示标准的兼容性研究%Research on Compatibility of Ground Signal Indication Criterions between Dedicated Passenger Line and Conventional Railway Line

    Institute of Scientific and Technical Information of China (English)

    石先明

    2016-01-01

    Dedicated passenger line ( DPL ) and conventional railway line are using different technical specifications for ground signal setting and signal indication. When DPL joints conventional railway lines of CTCS2/3 , compatibility problem exists in the junction station and the section in perspective of signal setting and signal indication, which poses threat to normal traffic. The suggested solution is that the starting signal of the junction station uses the starting signal and the normal red-aspect specified for conventional railways, and signal indication criterions for dedicated railway and conventional railway are implemented respectively after the outgoing route is opened. Moreover, the paper studies and presents other programs to improve the compatibility.%目前我国客运专线铁路和普通铁路的地面信号机设置及其信号显示方式分别采用不同的技术标准。当客运专线铁路与CTCS-2/3级普通铁路交汇衔接时,接轨站及其区间的地面信号机设置及其显示方式存在兼容性问题,给铁路运输造成安全隐患。推荐的解决方案是:接轨站出站信号机采用普通铁路标准的出站信号机机构和常态点红灯方式,开放发车进路后分别执行普通铁路和客运专线铁路的信号显示标准。另外,文中还研究提出了可进一步完善兼容性的其他改进方案。

  17. Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV.

    OpenAIRE

    1994-01-01

    During cultivation of the Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (BL) line Akata, it was noted that EBV DNA is lost from some of the cells. Isolation of EBV-positive and EBV-negative clones with the same origin made it possible to examine the effects of EBV in BL cells. The results indicate that malignant phenotypes of BL, such as growth in low serum, anchorage-independent growth in soft agar, and tumorigenicity in nude mice, are dependent on the presence of EBV genomes and unde...

  18. Transmission Lines or Poles, Electric, Electricity Transmission Lines; electran; Major above ground high voltage electrical transmission lines as shown on USGS 7.5 minute topo quads and/or as confirmed through identification of visible right of way cuts on digital orthophotgraphy., Published in 2001, 1:4800 (1in=400ft) scale, State of Rhode Island and Providence Plantations.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Transmission Lines or Poles, Electric dataset, published at 1:4800 (1in=400ft) scale, was produced all or in part from Orthoimagery information as of 2001. It...

  19. First-line anti-tubercular drug resistance of mycobacterial strains from re-treatment cases that were smear-positive at 4th month onwards under the Revised National Tuberculosis Control Program

    OpenAIRE

    Surajit Lahiri; Abhijit Mukherjee; Supabitra Hazra; Pulak Jana; Sandip Roy; Brojo Kishore Saha

    2015-01-01

    Background: Programmatic management of drug-resistant TB (PMDT) under the RNTCP is being implemented in West Bengal in a phased manner since 2011. During the initial years MDR-TB cases were identified based on criteria A. This study examines the first line anti-tubercular drug resistance pattern of mycobacteria cultured from sputum samples of MDR suspects who were retreatment cases smear positive from 4 th month onwards. Materials and Methods: In the following retrospective record based study...

  20. A Method of Drawing Positioning Line of CT/MR Image Sequence Based on Web%一种基于 Web的 CT/MR 图像序列定位线绘制的方法

    Institute of Scientific and Technical Information of China (English)

    谢勤岚; 夏超; 苑金龙

    2014-01-01

    This paper introduces a positioning line drawing method of CT /MR image sequences based on Web in detail . This method uses the effective and accurate positioning line algorithm on service terminal and displaying algorithm on the client by combining the WADO ( Web Access to DICOM Persistent Object ) protocol in DICOM3.0 ( Digital imaging and Communications in Medicine ) standards with the data informations from DICOM files .It achieves the positioning line of CT/MR images sequence displaying on the browser and provides an important auxiliary tool for the accurate diagnosis in the remote consultation .%提出了一种基于Web的CT/MR图像序列定位线绘制实现的方法,该方法结合DICOM3.0标准中WADO协议和DIOCM文件的数据信息,采取高效准确的服务端定位线算法和Web客户端的显示算法,实现了CT/MR图像序列定位线在浏览器上的显示,可为远程医疗的精确诊断提供重要辅助工具.

  1. Spotlight on crizotinib in the first-line treatment of ALK-positive advanced non-small-cell lung cancer: patients selection and perspectives

    Directory of Open Access Journals (Sweden)

    Giroux Leprieur E

    2016-06-01

    Full Text Available Etienne Giroux Leprieur,1,2 Vincent Fallet,3,4 Jacques Cadranel,3,4 Marie Wislez3,4 1Respiratory Diseases and Thoracic Oncology Department, APHP-Ambroise Paré Hospital, Boulogne-Billancourt, France; 2EA4340 Laboratory, UVSQ, Paris-Saclay University, France; 3Respiratory Diseases Department, APHP – Tenon Hospital, Paris, France; 4Sorbonne University, GRC 04, UPMC Univ Paris 06, France Abstract: Around 4% of advanced non-small-cell lung cancers (NSCLCs have an ALK rearrangement at the time of diagnosis. This molecular feature is more frequent in young patients, with no/light smoking habit and with adenocarcinoma pathological subtype. Crizotinib is a tyrosine kinase inhibitor, targeting ALK, ROS1, RON, and MET. The preclinical efficacy results led to a fast-track clinical development. The US Food and Drug Administration (FDA approval was achieved after the Phase I clinical trial in 2011 in ALK-rearranged advanced NSCLC progressing after a first-line treatment. In 2013, the randomized Phase III trial PROFILE-1007 confirmed the efficacy of crizotinib in ALK-rearranged NSCLC, compared to cytotoxic chemotherapy, in second-line setting or more. In 2014, the PROFILE-1014 trial showed the superiority of crizotinib in the first-line setting compared to the pemetrexed platinum doublet chemotherapy. The response rate was 74%, and the progression-free survival was 10.9 months with crizotinib. Based on these results, crizotinib received approval from the FDA and European Medicines Agency for first-line treatment of ALK-rearranged NSCLC. The various molecular mechanisms at the time of the progression (ALK mutations or amplification, ALK-independent mechanisms encourage performing re-biopsy at the time of progression under crizotinib. The best treatment strategy at the progression (crizotinib continuation beyond progression, switch to second-generation tyrosine kinase inhibitors, or cytotoxic chemotherapy depends on the phenotype of the progression, the

  2. 基于机器视觉的玉米秸秆行实时定位机器人设计%Design for Line Real-time Positioning Robot of Corn Stalk Based on Machine Vision

    Institute of Scientific and Technical Information of China (English)

    张丽; 胡应占; 汪小志; 鲍秀兰

    2016-01-01

    In order to achieve accurate positioning robot corn stalk line , the structure of farming corn robot is improved , and it put forward a kind of RSSI localization method based on Taylor series expansion , and increase the corn stalk line robot positioning accuracy .Together with the method of PID closed-loop feedback control ,by using high resolution camera gathering image ,the positioning system use the PC master side image processing the displacement of the robot , realized the real-time positioning function .In order to verify the reliability of the robot corn stalk line , and adopt the method of field experiments on the performance of the robot were tested .Through test ,it was found that the proposed RSSI positioning method of positioning accuracy is higher , and the image processing system can accurate calibration of corn stalk line , which can accomplish the precise positioning of the robot in the corn field and avoid the robot in the process of opera-tion causing damage to the crops .%为了实现机器人玉米秸秆行的精确定位,对耕作玉米机器人的结构进行了改进,并提出了一种基于泰勒级数展开式的RSSI 定位方法,提高了机器人玉米秸秆行的定位精度. 定位系统使用高清晰度的摄像机采集图像,并采用PID闭环反馈的方式控制机器人的位移,利用 PC 主控端图像处理,实现了实时定位功能. 为了验证机器人玉米秸秆行定位的可靠性,采用田间试验的方法对机器人的性能进行了测试. 结果表明:RSSI 定位方法的定位精度较高,且图像处理系统可以准确地标定玉米秸秆行,实现机器人在玉米田中的精确定位,避免了机器人在作业过程中对农作物造成损害.

  3. Evaluating transmission towers potentials during ground faults

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    During ground faults on transmission lines, a number of towers near the fault are likely to acquire high potentials to ground. These tower voltages, if excessive, may present a hazard to humans and animals. This paper presents analytical methods in order to determine the transmission towers potentials during ground faults, for long and short lines. The author developed a global systematic approach to calculate these voltages, which are dependent of a number of factors. Some of the most important factors are: magnitudes of fault currents, fault location with respect to the line terminals, conductor arrangement on the tower and the location of the faulted phase, the ground resistance of the faulted tower, soil resistivity, number, material and size of ground wires. The effects of these factors on the faulted tower voltages have been also examined for different types of power lines.

  4. Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein-Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines.

    Science.gov (United States)

    Perez-Chacon, Gema; de Los Rios, Cristobal; Zapata, Juan M

    2014-11-01

    Indole-3-carbinol (I3C) is a natural product found in broadly consumed plants of the Brassica genus, such as broccoli, cabbage, and cauliflower, which exhibits anti-tumor effects through poorly defined mechanisms. I3C can be orally administered and clinical trials have demonstrated that I3C and derivatives are safe in humans. In this study we show that I3C efficiently induces apoptosis in cell lines derived from EBV-positive Burkitt's lymphomas (virus latency I/II), while it does not have any cytotoxic activity against EBV-negative Burkitt's lymphomas and immortalized EBV-infected lymphoblastoid cell lines (virus latency III). The effect of I3C in EBV-positive Burkitt's lymphoma is very specific, since only I3C and its C6-methylated derivative, but not other 3-substituted indoles, have an effect on cell viability. I3C treatment caused apoptosis characterized by loss of mitochondria membrane potential and caspase activation. I3C alters the expression of proteins involved in the control of apoptosis and transcription regulation in EBV-positive Burkitt's lymphoma cell lines. Among those, cMYC, cIAP1/2 and XIAP downmodulation at mRNA and protein level precede apoptosis induction, thus suggesting a role in I3C cytotoxicity. We also showed that I3C and, more particularly, its condensation dimer 3,3'-diindolylmethane (DIM) prolonged survival and reduced tumor burden of mice xenotransplanted with EBV-positive Burkitt's lymphoma Daudi cells. In summary these results, together with previous reports from clinical trials indicating the lack of toxicity in humans of I3C and derivatives, support the use of these compounds as a new therapeutic approach for treating patients with endemic (EBV-positive) Burkitt's lymphoma.

  5. Research on the impact of one line failure for a mooring assisted dynamic positioning system%锚泊辅助动力定位系统单缆失效影响研究

    Institute of Scientific and Technical Information of China (English)

    张峰; 王磊; 李勇跃

    2012-01-01

    For a semi-submersible platform, one mooring line may fail when the mooring-assisted dynamic positioning system works in the sea. As an example, a semi-submersible platform has been considered and a mooring-assisted dynamic positioning system has been designed. By using the time domain simulation, the impact of one mooring line failure on the offsets and power utilization of the platform will be analyzed. From the analysis result, it is suggested that under severe conditions, loosing the tension of the leeward lines can reduce power consumption, improve positioning accuracy and the safety of the positioning system, which will be helpful to the further engineering applications of the mooring-assisted dynamic positioning system.%针对半潜式钻井平台锚泊辅助动力定位系统在海上作业时可能会出现的单缆失效情况.以一艘半潜式平台为例,设计锚泊辅助动力定位系统.通过全动态时域模拟,研究不同的单缆失效模式对半潜式平台锚泊辅助动力定位系统功率消耗、定位精度、缆绳张力等的影响.根据分析结果,在极端海况下,松弛锚泊辅助动力定位系统的背风缆有助于降低定位系统的功率消耗,提高定位精度和系统的安全性,从而为锚泊辅助动力定位系统的工程应用提供一些参考.

  6. GPS Multipath Fade Measurements to Determine L-Band Ground Reflectivity Properties

    Science.gov (United States)

    Kavak, Adnan; Xu, Guang-Han; Vogel, Wolfhard J.

    1996-01-01

    In personal satellite communications, especially when the line-of-sight is clear, ground specular reflected signals along with direct signals are received by low gain, almost omni-directional subscriber antennas. A six-channel, C/A code processing, GPS receiver with an almost omni-directional patch antenna was used to take measurements over three types of ground to characterize 1.575 GHz specular ground reflections and ground dielectric properties. Fade measurements were taken over grass, asphalt, and lake water surfaces by placing the antenna in a vertical position at a fixed height from the ground. Electrical characteristics (conductivity and dielectric constant) of these surfaces (grass, asphalt, lake water) were obtained by matching computer simulations to the experimental results.

  7. Effect of atmospheric turbulence on the bit error probability of a space to ground near infrared laser communications link using binary pulse position modulation and an avalanche photodiode detector

    Science.gov (United States)

    Safren, H. G.

    1987-01-01

    The effect of atmospheric turbulence on the bit error rate of a space-to-ground near infrared laser communications link is investigated, for a link using binary pulse position modulation and an avalanche photodiode detector. Formulas are presented for the mean and variance of the bit error rate as a function of signal strength. Because these formulas require numerical integration, they are of limited practical use. Approximate formulas are derived which are easy to compute and sufficiently accurate for system feasibility studies, as shown by numerical comparison with the exact formulas. A very simple formula is derived for the bit error rate as a function of signal strength, which requires only the evaluation of an error function. It is shown by numerical calculations that, for realistic values of the system parameters, the increase in the bit error rate due to turbulence does not exceed about thirty percent for signal strengths of four hundred photons per bit or less. The increase in signal strength required to maintain an error rate of one in 10 million is about one or two tenths of a db.

  8. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Henry, Jon C. [Department of Surgery, Ohio State University Medical Center, Columbus, OH (United States); Park, Jong-Kook; Jiang, Jinmai; Kim, Ji Hye [College of Pharmacy, Ohio State University, Columbus, OH (United States); Nagorney, David M.; Roberts, Lewis R. [Divisions of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN (United States); Banerjee, Soma [Center for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata (India); Schmittgen, Thomas D., E-mail: Schmittgen.2@osu.edu [College of Pharmacy, Ohio State University, Columbus, OH (United States)

    2010-12-03

    Research highlights: {yields} miR-199a-3p targets CD44 in HCC. {yields} Proliferation and invasion are reduced by miR-199a-3p in CD44+ HCC. {yields} miR-199a-3p is reduced and CD44 protein is increased in HCC tissues. {yields} The duplex form of miR-199a-3p mimetic is required for activity. -- Abstract: Previous work by us and others reported decreased expression of miR-199a-3p in hepatocellular carcinoma (HCC) tissues compared to adjacent benign tissue. We report here a significant reduction of miR-199a-3p expression in 7 HCC cell lines. To determine if miR-199a-3p has a tumor suppressive role, pre-miR-199a-3p oligonucleotides were transfected into the HCC cell lines. Pre-miR-199a-3p oligonucleotide reduced cell proliferation by approximately 60% compared to control oligonucleotide in only two cell lines (SNU449 and SNU423); the proliferation of the other 5 treated cell lines was similar to control oligonucleotide. A pre-miR-199a-3p oligonucleotide formulated with chemical modifications to enhance stability while preserving processing, reduced cell proliferation in SNU449 and SNU423 to the same extent as the commercially available pre-miR-199a-3p oligonucleotide. Furthermore, only the duplex miR-199a-3p oligonucleotide, and not the guide strand alone, was effective at reducing cell viability. Since a CD44 variant was essential for c-Met signaling [V. Orian-Rousseau, L. Chen, J.P. Sleeman, P. Herrlich, H. Ponta, CD44 is required for two consecutive steps in HGF/c-Met signaling, Genes Dev. 16 (2002) 3074-3086] and c-Met is a known miR-199a-3p target, we hypothesized that miR-199a-3p may also target CD44. Immunoblotting confirmed that only the two HCC lines that were sensitive to the effects of pre-miR-199a-3p were CD44+. Direct targeting of CD44 by miR-199a-3p was confirmed using luciferase reporter assays and immunoblotting. Transfection of miR-199a-3p into SNU449 cells reduced in vitro invasion and sensitized the cells to doxorubicin; both effects were enhanced

  9. Existence of 2m-1 Positive Solutions for Sturm-Liouville Boundary Value Problems with Linear Functional Boundary Conditions on the Half-Line

    Directory of Open Access Journals (Sweden)

    Yanmei Sun

    2012-01-01

    Full Text Available By using the Leggett-Williams fixed theorem, we establish the existence of multiple positive solutions for second-order nonhomogeneous Sturm-Liouville boundary value problems with linear functional boundary conditions. One explicit example with singularity is presented to demonstrate the application of our main results.

  10. Alloactivated HLA class II-positive T-cell lines induce IL-2 reactivity but lack accessory cell function in mixed leukocyte culture

    DEFF Research Database (Denmark)

    Odum, N; Dickmeiss, E; Hofmann, B

    1989-01-01

    ). From 70 to 90% of the Ta were HLA class II-positive as judged by the reactions with HLA class II-reactive monoclonal antibodies, and the Ta carried the DR allospecificities of the original T-cell donor when typed in the microcytotoxic test using DR-specific alloantisera. Neither irradiated nor...

  11. 'Grounded' Politics

    DEFF Research Database (Denmark)

    Schmidt, Garbi

    2012-01-01

    play within one particular neighbourhood: Nørrebro in the Danish capital, Copenhagen. The article introduces the concept of grounded politics to analyse how groups of Muslim immigrants in Nørrebro use the space, relationships and history of the neighbourhood for identity political statements....... The article further describes how national political debates over the Muslim presence in Denmark affect identity political manifestations within Nørrebro. By using Duncan Bell’s concept of mythscape (Bell, 2003), the article shows how some political actors idealize Nørrebro’s past to contest the present...

  12. Phase III, Double-Blind, Randomized Trial That Compared Maintenance Lapatinib Versus Placebo After First-Line Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 1/2-Positive Metastatic Bladder Cancer.

    Science.gov (United States)

    Powles, Thomas; Huddart, Robert A; Elliott, Tony; Sarker, Shah-Jalal; Ackerman, Charlotte; Jones, Robert; Hussain, Syed; Crabb, Simon; Jagdev, Satinder; Chester, John; Hilman, Serena; Beresford, Mark; Macdonald, Graham; Santhanam, Sundar; Frew, John A; Stockdale, Andrew; Hughes, Simon; Berney, Daniel; Chowdhury, Simon

    2017-01-01

    Purpose To establish whether maintenance lapatinib after first-line chemotherapy is beneficial in human epidermal growth factor receptor (HER) 1/HER2-positive metastatic urothelial bladder cancer (UBC). Methods Patients with metastatic UBC were screened centrally for HER1/HER2 overexpression. Patients who screened positive for HER1/2 and who did not have progressive disease during chemotherapy (four to eight cycles) were randomly assigned one to one to lapatinib or placebo after completion of first-line/initial chemotherapy for metastatic disease. The primary end point was progression-free survival (PFS). Results Between 2007 and 2013, 446 patients with UBC were screened, and 232 with HER1- or HER2-positive disease were randomly assigned. The median PFS for lapatinib and placebo was 4.5 (95% CI, 2.8 to 5.4) and 5.1 (95% CI, 3.0 to 5.8) months, respectively (hazard ratio, 1.07; 95% CI, 0.81 to 1.43; P = .63). The overall survival for lapatinib and placebo was 12.6 (95% CI, 9.0 to 16.2) and 12.0 (95% CI, 10.5 to 14.9) months, respectively (hazard ratio, 0.96; 95% CI, 0.70 to 1.31; P = .80). Discontinuation due to adverse events were similar in both arms (6% lapatinib and 5% placebo). The rate of grade 3 to 4 adverse events for lapatinib and placebo was 8.6% versus 8.1% ( P = .82). Preplanned subset analysis of patients strongly positive for HER1/HER2 (3+ on immunohistochemistry; n = 111), patients positive for only HER1 (n = 102), and patients positive for only HER2 (n = 42) showed no significant benefit with lapatinib in terms of PFS and overall survival ( P > .05 for each). Conclusion This trial did not find significant improvements in outcome by the addition of maintenance lapatinib to standard of care.

  13. Application of RTK Intelligent Positioning System in Project of High Voltage Transmission Line%GPS -RTK 在高压输电线路工程中的应用

    Institute of Scientific and Technical Information of China (English)

    王晓静; 朱宝训; 何保喜

    2014-01-01

    In survey project of high voltage transmission line , due to effect of vegetations , the indivisibility condition is very poor;conventional surveying method results in not only a high cost , but also a long construction period and high surveying workload , there-fore it is difficult to ensure the restored line to be in consistence with the original straight line .With the aid of GPS ( Global Positioning System) technology, survey project of high voltage transmission line can be accomplished conveniently , swiftly, and accurately.The real-time dynamic measurement of RTK ( Real Time Kinematic ) intelligent positioning system discussed in this paper is characterized by its functions of calculating relative relationships among points , lines and surfaces as well as the function of visual graphical display , and is able to accomplish construction survey , record, as well as high intelligent and integration in calculation .Compared with tradi-tional surveying techniques , it is free from constraints of visual conditions , and can be applied to long distance , while maintaining high speed and high precision .In general, real-time dynamic measurement of RTK intelligent positioning system can significantly improve the production efficiency in engineering applications .%在高压输电线路工程测量中,由于受植被影响,通视条件极差;常规测量方法不但赔偿费用高,而且工期长,测量工作量大,很难保证恢复后的直线与原直线一致。随着全球定位系统GPS ( Global Positioning System )的广泛应用,可借助GPS定位技术方便、快速、准确地进行测量。本文论述的实时动态测量RTK ( Real Time Kine2 matic)智能定位系统,具有点、线、面之间相对关系的计算功能及直观的图形显示功能,实现了施工测量、记录、计算的高度智能化、一体化;与传统的测量技术相比,不受通视条件的限制,测量的距离远、速度快、精度高;在

  14. Estimating quality adjusted progression free survival of first-line treatments for EGFR mutation positive non small cell lung cancer patients in The Netherlands.

    Science.gov (United States)

    Verduyn, S Cora; Biesma, Bonne; Schramel, Franz M N H; van der Scheer, Feike W; Langenfeld, Merel K; de Peuter, Maria A; Dingemans, Anne-Marie C

    2012-09-10

    Gefitinib, a tyrosine kinase inhibitor, is an effective treatment in advanced non-small cell lung cancer (NSCLC) patients with an activating mutation in the epidermal growth factor receptor (EGFR). Randomised clinical trials showed a benefit in progression free survival for gefitinib versus doublet chemotherapy regimens in patients with an activated EGFR mutation (EGFR M+). From a patient perspective, progression free survival is important, but so is health-related quality of life. Therefore, this analysis evaluates the Quality Adjusted progression free survival of gefitinib versus three relevant doublet chemotherapies (gemcitabine/cisplatin (Gem/Cis); pemetrexed/cisplatin (Pem/Cis); paclitaxel/carboplatin (Pac/Carb)) in a Dutch health care setting in patients with EGFR M+ stage IIIB/IV NSCLC. This study uses progression free survival rather than overall survival for its time frame in order to better compare the treatments and to account for the influence that subsequent treatment lines would have on overall survival analysis. Mean progression free survival for Pac/Carb was obtained by extrapolating the median progression free survival as reported in the Iressa-Pan-Asia Study (IPASS). Data from a network meta-analysis was used to estimate the mean progression free survival for therapies of interest relative to Pac/Carb. Adjustment for health-related quality of life was done by incorporating utilities for the Dutch population, obtained by converting FACT-L data (from IPASS) to utility values and multiplying these with the mean progression free survival for each treatment arm to determine the Quality Adjusted progression free survival. Probabilistic sensitivity analysis was carried out to determine 95% credibility intervals. The Quality Adjusted progression free survival (PFS) (mean, (95% credibility interval)) was 5.2 months (4.5; 5.8) for Gem/Cis, 5.3 months (4.6; 6.1) for Pem/Cis; 4.9 months (4.4; 5.5) for Pac/Carb and 8.3 (7.0; 9.9) for gefitinib. In the Dutch

  15. Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).

    Science.gov (United States)

    Wassmann, Barbara; Pfeifer, Heike; Goekbuget, Nicola; Beelen, Dietrich W; Beck, Joachim; Stelljes, Matthias; Bornhäuser, Martin; Reichle, Albrecht; Perz, Jolanta; Haas, Rainer; Ganser, Arnold; Schmid, Mathias; Kanz, Lothar; Lenz, Georg; Kaufmann, Martin; Binckebanck, Anja; Brück, Patrick; Reutzel, Regina; Gschaidmeier, Harald; Schwartz, Stefan; Hoelzer, Dieter; Ottmann, Oliver G

    2006-09-01

    The best strategy for incorporating imatinib in front-line treatment of Ph+ acute lymphoblastic leukemia (ALL) has not been established. We enrolled 92 patients with newly diagnosed Ph+ ALL in a prospective, multicenter study to investigate sequentially 2 treatment schedules with imatinib administered concurrent to or alternating with a uniform induction and consolidation regimen. Coadministration of imatinib and induction cycle 2 (INDII) resulted in a complete remission (CR) rate of 95% and polymerase chain reaction (PCR) negativity for BCR-ABL in 52% of patients, compared with 19% in patients in the alternating treatment cohort (P = .01). Remarkably, patients with and without a CR after induction cycle 1 (INDI) had similar hematologic and molecular responses after concurrent imatinib and INDII. In the concurrent cohort, grades III and IV cytopenias and transient hepatotoxicity necessitated interruption of induction in 87% and 53% of patients, respectively; however, duration of induction was not prolonged when compared with patients receiving chemotherapy alone. No imatinib-related severe hematologic or nonhematologic toxicities were noted with the alternating schedule. In each cohort, 77% of patients underwent allogeneic stem cell transplantation (SCT) in first CR (CR1). Both schedules of imatinib have acceptable toxicity and facilitate SCT in CR1 in the majority of patients, but concurrent administration of imatinib and chemotherapy has greater antileukemic efficacy.

  16. Debris-covered glacier anomaly? Morphological factors controlling changes in the mass balance, surface area, terminus position, and snow line altitude of Himalayan glaciers

    Science.gov (United States)

    Salerno, Franco; Thakuri, Sudeep; Tartari, Gianni; Nuimura, Takayuki; Sunako, Sojiro; Sakai, Akiko; Fujita, Koji

    2017-08-01

    What are the main morphological factors that control the heterogeneous responses of debris-covered glaciers to climate change in the southern central Himalaya? A debate is open whether thinning rates on debris-covered glaciers are comparable to those of debris-free ones. Previous studies have adopted a deterministic approach, which is indispensable, but is also limiting in that only a few glaciers can be monitored. In this context, we propose a statistical analysis based on a wider glacier population as a complement to these deterministic studies. We analysed 28 glaciers situated on the southern slopes of Mt. Everest in the central southern Himalaya during the period 1992-2008. This study combined data compiled by three distinct studies for a common period and population of glaciers for use in a robust statistical analysis. Generally, surface gradient was the main morphological factor controlling the features and responses of the glaciers to climate change. In particular, the key points that emerged are as follows. 1) Reduced downstream surface gradient is responsible for increased glacier thinning. 2) The development of supraglacial ponds is a further controlling factor of glacier thinning: where supraglacial ponds develop, the glaciers register further surface lowering. 3) Debris coverage and thickness index were not found to be significantly responsible for the development of supraglacial ponds, changes in elevation, or shifts in snow line altitude.

  17. MARVELS-1: A Face-on Double-lined Binary Star Masquerading as a Resonant Planetary System and Consideration of Rare False Positives in Radial Velocity Planet Searches

    Science.gov (United States)

    Wright, Jason T.; Roy, Arpita; Mahadevan, Suvrath; Wang, Sharon X.; Ford, Eric B.; Payne, Matt; Lee, Brian L.; Wang, Ji; Crepp, Justin R.; Gaudi, B. Scott; Eastman, Jason; Pepper, Joshua; Ge, Jian; Fleming, Scott W.; Ghezzi, Luan; González-Hernández, Jonay I.; Cargile, Phillip; Stassun, Keivan G.; Wisniewski, John; Dutra-Ferreira, Leticia; Porto de Mello, Gustavo F.; Maia, Márcio A. G.; Nicolaci da Costa, Luiz; Ogando, Ricardo L. C.; Santiago, Basilio X.; Schneider, Donald P.; Hearty, Fred R.

    2013-06-01

    We have analyzed new and previously published radial velocity (RV) observations of MARVELS-1, known to have an ostensibly substellar companion in a ~6 day orbit. We find significant (~100 m s-1) residuals to the best-fit model for the companion, and these residuals are naïvely consistent with an interior giant planet with a P = 1.965 days in a nearly perfect 3:1 period commensurability (|Pb /Pc - 3| MARVELS-1 with adaptive optics imaging at Keck; both are M dwarfs, one is likely bound, and the other is likely a foreground object. We explore false-alarm scenarios inspired by various curiosities in the data. Ultimately, a line profile and bisector analysis lead us to conclude that the ~100 m s-1 residuals are an artifact of spectral contamination from a stellar companion contributing ~15%-30% of the optical light in the system. We conclude that origin of this contamination is the previously detected RV companion to MARVELS-1, which is not, as previously reported, a brown dwarf, but in fact a G dwarf in a face-on orbit.

  18. The anterior to midaxillary line between the 4th or 5th intercostal space (Buelau position) is safe for the use of thoracostomy tubes in preterm and term infants.

    Science.gov (United States)

    Eifinger, Frank; Lenze, Miriam; Brisken, Katrin; Welzing, Lars; Roth, Bernhard; Koebke, Jürgen

    2009-06-01

    Thoracostomy tubes are widely used in neonatology. Complications occurred significantly more frequently in infants, especially neonates, than in adults. Principally, the access is the modified Buelau position which takes place in the anterior axillary line at the 4th or 5th intercostal space above the margin of the ribs. This study seeks to determine the characteristics and topographic conditions of the anatomical structures at the ventral and lateral thoracic wall in the preterm and term neonate. Fifteen formalin-fixed stillborns were prepared (nine male, six female, 28-43 weeks gestational age). The anatomical preparation involved the complete thoracic wall region. In all preparations, a venous vessel was detected at the lateral wall and was identified as v. thoracoepigastrica without accompanying artery. Arteria (a.) and vena (v.) thoracica interna were regularly found close to the sternal plate on both sides between rib and fascia. With increasing gestational ages the course of the v. thoracoepigastrica varied significantly between the left and right thoracic wall. It was demonstrated that the v. thoracoepigastrica regularly arose within the abdominal or thoracic subcutaneous fat and drained into the v. subclavia. The variance between its course was almost 5-12 mm to the lateral or medial side. At both thoracic sides, no other organs or organ structures except lung parenchyma could be detected when using the Buelau position. The anterior to midaxillary line between the 4th or 5th intercostal space (Buelau position) is safe for the use of thoracostomy tubes in preterm and term infants.

  19. MARVELS-1: A FACE-ON DOUBLE-LINED BINARY STAR MASQUERADING AS A RESONANT PLANETARY SYSTEM AND CONSIDERATION OF RARE FALSE POSITIVES IN RADIAL VELOCITY PLANET SEARCHES

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Jason T.; Roy, Arpita; Mahadevan, Suvrath; Wang, Sharon X.; Fleming, Scott W. [Center for Exoplanets and Habitable Worlds, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16802 (United States); Ford, Eric B.; Payne, Matt; Lee, Brian L.; Ge, Jian [Department of Astronomy, University of Florida, 211 Bryant Space Science Center, Gainesville, FL 32611-2055 (United States); Wang, Ji [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Crepp, Justin R. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556-5670 (United States); Gaudi, B. Scott; Eastman, Jason [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Pepper, Joshua; Cargile, Phillip; Stassun, Keivan G. [Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235 (United States); Ghezzi, Luan [Observatorio Nacional, Rua General Jose Cristino, 77, Rio de Janeiro, RJ 20921-400 (Brazil); Gonzalez-Hernandez, Jonay I. [Instituto de Astrofisica de Canarias (IAC), E-38200 La Laguna, Tenerife (Spain); Wisniewski, John [HL Dodge Department of Physics and Astronomy, University of Oklahoma, 440 W Brooks St, Norman, OK 73019 (United States); Dutra-Ferreira, Leticia, E-mail: jtwright@astro.psu.edu [Laboratorio Interinstitucional de e-Astronomia (LIneA), Rua General Jose Cristino 77, Rio de Janeiro, RJ 20921-400 (Brazil); and others

    2013-06-20

    We have analyzed new and previously published radial velocity (RV) observations of MARVELS-1, known to have an ostensibly substellar companion in a {approx}6 day orbit. We find significant ({approx}100 m s{sup -1}) residuals to the best-fit model for the companion, and these residuals are naievely consistent with an interior giant planet with a P = 1.965 days in a nearly perfect 3:1 period commensurability (|P{sub b} /P{sub c} - 3| < 10{sup -4}). We have performed several tests for the reality of such a companion, including a dynamical analysis, a search for photometric variability, and a hunt for contaminating stellar spectra. We find many reasons to be critical of a planetary interpretation, including the fact that most of the three-body dynamical solutions are unstable. We find no evidence for transits, and no evidence of stellar photometric variability. We have discovered two apparent companions to MARVELS-1 with adaptive optics imaging at Keck; both are M dwarfs, one is likely bound, and the other is likely a foreground object. We explore false-alarm scenarios inspired by various curiosities in the data. Ultimately, a line profile and bisector analysis lead us to conclude that the {approx}100 m s{sup -1} residuals are an artifact of spectral contamination from a stellar companion contributing {approx}15%-30% of the optical light in the system. We conclude that origin of this contamination is the previously detected RV companion to MARVELS-1, which is not, as previously reported, a brown dwarf, but in fact a G dwarf in a face-on orbit.

  20. Getting grounded: using Glaserian grounded theory to conduct nursing research.

    Science.gov (United States)

    Hernandez, Cheri Ann

    2010-03-01

    Glaserian grounded theory is a powerful research methodology for understanding client behaviour in a particular area. It is therefore especially relevant for nurse researchers. Nurse researchers use grounded theory more frequently than other qualitative analysis research methods because of its ability to provide insight into clients' experiences and to make a positive impact. However, there is much confusion about the use of grounded theory.The author delineates key components of grounded theory methodology, areas of concern, and the resulting implications for nursing knowledge development. Knowledge gained from Glaserian grounded theory research can be used to institute measures for enhancing client-nurse relationships, improving quality of care, and ultimately improving client quality of life. In addition, it can serve to expand disciplinary knowledge in nursing because the resulting substantive theory is a middle-range theory that can be subjected to later quantitative testing.

  1. Spectroscopic Parameters for Ozone and its Isotopes: Current Status, Prospects for Improvement, and the Identification of 16O16O17O and O-16O-16O-17 and O-16O-17O-16 Lines in Infrared Ground-Based and Stratospheric Solar Absorption Spectra

    Science.gov (United States)

    Rinsland, C. P.; Flaud, J.-M.; Goldman, A.; Perrin, A.; Camy-Peyret, C.; Smith, M. A. H.; Devi, V. Malathy; Benner, D. C.; Barbe, A.; Stephens, T. M.; hide

    1998-01-01

    We describe the updates to the spectroscopic parameters of ozone and its isotopes in the 1996 HITRAN compilation. Recent published studies not included in HITRAN are also summarized. Finally, we report the identification of infrared lines of the v(sub 3) bands of O-16O-16O-17 and O-16O-17O-16 in high-resolution solar spectra recorded by stratospheric balloon-borne and ground-based Fourier transform spectrometers.

  2. Effects of ground motion spatial variation on seismic response of a power transmission tower-line system%地震动空间变化对高压输电塔线体系地震反应的影响

    Institute of Scientific and Technical Information of China (English)

    田利; 李宏男; 王文明

    2013-01-01

    Here, effects of ground motion spatial variation on seismic response of a power transmission tower-line system were studied with numerical simulations. A three-dimensional finite element model for the power transmission tower-line coupled system considering the geometric nonlinearity of transmission line was established. Based on wave passage effect, coherency loss effect, different local site effect and multi-dimensional nature of ground motion, spatially varying ground motion time histories were simulated according to power spectral density function, coherency loss function and Code for Design of Seismic of Electrical Installations. The effects of wave passage, coherency loss and different local site effect on the seismic response of the transmission tower-line system were investigated, respectively. The results showed that the effects of ground motion spatial variation have significant influence on the seismic response of the transmission tower-line system; neglecting these effects may underestimate the response of the structure; the effects of ground motion spatial variation should be considered in seismic design of transmission line practical engineering.%通过数值模拟研究了地震动空间变化对高压输电塔线体系地震反应的影响.建立了输电塔线耦联体系三维有限元模型,考虑了输电线的几何非线性特征;在考虑地震动的行波效应、部分相干效应和局部场地效应以及多维性基础上,依据功率谱密度函数、相干函数和《电力设施抗震设计规范》模拟了空间变化地震动时程;分别研究了地震动空间变化的行波效应、部分相干效应和局部场地效应对输电塔线体系地震反应的影响.研究结果表明,地震动空间变化对输电塔线体系地震反应影响显著,忽略这些因素将会低估结构的反应.因此对于输电线路实际工程的抗震设计,需要考虑地震动空间变化效应的影响.

  3. The Development of Constructivist Grounded Theory

    Directory of Open Access Journals (Sweden)

    Jane Mills

    2006-03-01

    Full Text Available Constructivist grounded theory is a popular method for research studies primarily in the disciplines of psychology, education, and nursing. In this article, the authors aim to locate the roots of constructivist grounded theory and then trace its development. They examine key grounded theory texts to discern their ontological and epistemological orientation. They find Strauss and Corbin's texts on grounded theory to possess a discernable thread of constructivism in their approach to inquiry. They also discuss Charmaz's landmark work on constructivist grounded theory relative to her positioning of the researcher in relation to the participants, analysis of the data, and rendering of participants' experiences into grounded theory. Grounded theory can be seen as a methodological spiral that begins with Glaser and Strauss' original text and continues today. The variety of epistemological positions that grounded theorists adopt are located at various points on this spiral and are reflective of their underlying ontologies.

  4. First-line anti-tubercular drug resistance of mycobacterial strains from re-treatment cases that were smear-positive at 4 th month onwards under the Revised National Tuberculosis Control Program

    Directory of Open Access Journals (Sweden)

    Surajit Lahiri

    2015-01-01

    Full Text Available Background: Programmatic management of drug-resistant TB (PMDT under the RNTCP is being implemented in West Bengal in a phased manner since 2011. During the initial years MDR-TB cases were identified based on criteria A. This study examines the first line anti-tubercular drug resistance pattern of mycobacteria cultured from sputum samples of MDR suspects who were retreatment cases smear positive from 4 th month onwards. Materials and Methods: In the following retrospective record based study, data on Drug Sensitivity Testing (DST of sputum samples of MDR suspects between September 2011 and August 2012 were collected from the IRL Kolkata and analysed. Sputum samples, collected in the districts maintaining adequate aseptic containment measures, were decontaminated and centrifuged and the sediment inoculated on LJ medium. Probable M. tuberculosis colonies were identified by typical colony characteristics and Ziehl-Neelsen (ZN staining. Sensitivity of the four 1 st line drugs (Streptomycin, Isoniazid, Ethambutol and Rifampicin was deduced by the economic variant of the proportion method. Results: Of all the 917 MDR suspects whose sputum was examined, 64 mycobacteria culture positive strains (6.98% were mono-resistant to any of the four first line anti-tubercular drugs. Among the mono-resistant strains 43 (4.69% were resistant to Rifampicin while 12 (1.31% were resistant to INH. There were a total 78 (8.51% poly drug-resistant strains. MDR-TB strains were seen in 741 (80.81% samples. Conclusion: The magnitude of drug resistance were very high among retreatment patients that were smear positive from 4 th months onwards probably because of repeated courses of anti-tubercular drugs prior to drug sensitivity testing (DST. The decision of the PMDT to enlist all retreatment patients as MDR suspects at initiation will result in early identification and treatment of MDR-TB patients.

  5. Ground target localization algorithm for semi-active laser terminal correction projectile

    Directory of Open Access Journals (Sweden)

    Xing-long Li

    2016-06-01

    Full Text Available A target localization algorithm, which uses the measurement information from onboard GPS and onboard laser detector to acquire the target position, is proposed to obtain the accurate position of ground target in real time in the trajectory correction process of semi-active laser terminal correction projectile. A target localization model is established according to projectile position, attitude and line-of-sight angle. The effects of measurement errors of projectile position, attitude and line-of-sight angle on localization accuracy at different quadrant elevation angles are analyzed through Monte-Carlo simulation. The simulation results show that the measurement error of line-of-sight angle has the largest influence on the localization accuracy. The localization accuracy decreases with the increase in quadrant elevation angle. However, the maximum localization accuracy is less than 7 m. The proposed algorithm meets the accuracy and real-time requirements of target localization.

  6. Establishment and characterization of A novel Philadelphia-chromosome positive chronic myeloid leukemia cell line, TCC-S, expressing P210 and P190 BCR/ABL transcripts but missing normal ABL gene.

    Science.gov (United States)

    Van, Phan Nguyen Thanh; Xinh, Phan Thi; Kano, Yasuhiko; Tokunaga, Katsushi; Sato, Yuko

    2005-03-01

    A novel Philadelphia-chromosome positive (Ph+) cell line, TCC-S, has been established from a patient with Ph+ chronic myeloid leukemia (CML) in the blastic crisis. TCC-S cells were shown to express both P210 and P190 BCR/ABL transcripts by reverse transcriptase-polymerase chain reaction (PCR), although quantitative-PCR revealed that TCC-S cells mainly expressed P210 BCR/ABL transcript. Karyotype analysis revealed several triploid clones which constantly harbored two der(9)del(9) (p12)t(9;22) (q34;qll)s and two del(9) (q21)s. The der(9)del(9) (p12)t(9;22) (q34;q11) is rarely found in other CML cell lines. Moreover, to the best of our knowledge, del(9) (q21) resulting in missing of a restrict region including normal ABL gene has not been found among CML cell lines previously described. Thus, TCC-S cells with only BCR/ABL gene and no normal ABL gene may be a useful tool for functional study of ABL in Ph+ CML.

  7. Analysis on Zero Sequence Current Distribution Characteristic of Grounding Faults Occurred in Double-Circuit Transmission Lines on The Same Tower%同塔双回线路接地故障零序电流分布特性分析

    Institute of Scientific and Technical Information of China (English)

    曾耿晖; 蔡泽祥; 陈桥平; 刘为雄

    2011-01-01

    The distribution regularity of zero-sequence current, which appears during external and internal grounding faults occurred in double-circuit transmission lines on the same tower under different operation modes, different zero-sequence mutual inductance and different fault locations, is analyzed. For external grounding faults, the impact of different zero-sequence impedance of double-circuit transmission lines on the same tower is mainly considered; for internal grounding faults, the impacts of zero-sequence mutual inductances and fault locations under following conditions are considered: parallel operation of both transmission lines; one transmission line is energized and in the stand-by state while the other one is artificially grounded for the maintenance. The effects of "zero-sequence magnetic assist" and "zero-sequence degaussing", which are caused by the flowing of zero-sequence currents of both transmission lines on the same tower in the same direction and by those in the opposite direction respectively, lead to variation of distribution regularity of zero-sequence currents, and in extreme circumstance the out-of-limit of the first zone of zero-sequence over-current protection may occur. Based on practical calculation examples of Guangdong power grid, the setting measures are put forward to avoid the out-of-limit of the first zone of zero-sequence over-current protection for double-circuit transmission lines on the same tower. It is also proposed that in the setting of the first zone of zero-sequence over-current protection for double-circuit transmission lines on the same tower, the comprehensive effects of operation modes of double-circuit transmission lines on the same tower, the extent of zero-sequence mutual induction and fault locations should be taken into account to avoid the malfunction of the first zone of zero-sequence over-current protection of adjacent healthy transmission lines due to the affect of mutual induction while grounding

  8. Ground calibrations of Nuclear Compton Telescope

    Science.gov (United States)

    Chiu, Jeng-Lun; Liu, Zhong-Kai; Bandstra, Mark S.; Bellm, Eric C.; Liang, Jau-Shian; Perez-Becker, Daniel; Zoglauer, Andreas; Boggs, Steven E.; Chang, Hsiang-Kuang; Chang, Yuan-Hann; Huang, Minghuey A.; Amman, Mark; Chiang, Shiuan-Juang; Hung, Wei-Che; Lin, Chih-Hsun; Luke, Paul N.; Run, Ray-Shine; Wunderer, Cornelia B.

    2010-07-01

    The Nuclear Compton Telescope (NCT) is a balloon-borne soft gamma ray (0.2-10 MeV) telescope designed to study astrophysical sources of nuclear line emission and polarization. The heart of NCT is an array of 12 cross-strip germanium detectors, designed to provide 3D positions for each photon interaction with full 3D position resolution to imaging, effectively reduces background, and enables the measurement of polarization. The keys to Compton imaging with NCT's detectors are determining the energy deposited in the detector at each strip and tracking the gamma-ray photon interaction within the detector. The 3D positions are provided by the orthogonal X and Y strips, and by determining the interaction depth using the charge collection time difference (CTD) between the anode and cathode. Calibrations of the energy as well as the 3D position of interactions have been completed, and extensive calibration campaigns for the whole system were also conducted using radioactive sources prior to our flights from Ft. Sumner, New Mexico, USA in Spring 2009, and from Alice Springs, Australia in Spring 2010. Here we will present the techniques and results of our ground calibrations so far, and then compare the calibration results of the effective area throughout NCT's field of view with Monte Carlo simulations using a detailed mass model.

  9. Magnetic bearing optical delay line

    NARCIS (Netherlands)

    Dool, T.C. van den; Kamphues, F.G.; Fouss, B.; Henrioulle, K.; Hogenhuis, H.

    2004-01-01

    TNO TPD, in close cooperation with Micromega-Dynamics and Dutch Space, has developed an advanced Optical Delay Line (ODL) for use in PRIMA, GENIE and other ground based interferometers. The delay line design is modular and flexible, which makes scaling for other applications a relatively easy task.

  10. Grounded coplanar waveguide defected ground structure enabled mulitlayered passive circuits

    Science.gov (United States)

    Schlieter, Daniel Benjamin

    Passive circuits are essential to microwave and millimeter-wave (mm-wave) frequency design, especially as new commercial applications emerge for complementary metal-oxide semiconductor (CMOS) integrated circuits. However, it is challenging to design distributed passive circuits for CMOS due to the substrate loss and thin dielectric layers of the back-end-of-line (BEOL). Furthermore, distributed passive circuits need to be adapted for compactness and integration while overcoming these challenges and maintaining high performance. Grounded coplanar waveguide defected ground structures meet this need for compact and integrable passive circuits by utilizing the top and bottom ground planes of the transmission line to implement circuit elements. Defected ground structures (DGS) are distributed elements realized by etching specific patterns into the ground planes of transmission lines. These structures can be used in conjunction with the center conductor of planar transmission lines to reduce circuit size and/or improve performance. By implementing DGS in grounded coplanar waveguide (GCPW) multiple resonances and higher impedances can be achieved. The resonant-based GCPW DGS are more compact than their microstrip and CPW counterparts and fit well into the vertical technology of back-end-of-line CMOS. This research demonstrates up to 80% size reduction at 5.8GHz by realizing spiral-shaped DGS in GCPW and applying the resulting GCPW DGS unit cell to a dual-behavior band-pass filter. The filter has been scaled to 60GHz and realized in a 130nm CMOS process by using floating metal strips to reduce the impact of the lossy silicon substrate. The impedance-based GCPW DGS, called EG-GCPW, have up to a 20:1 impedance ratio on Rogers RT/DuroidRTM 5880 and an impedance ratio of 15:1 on a benzocyclobutene post-CMOS process. These high impedance ratios increased the power division ratio of an unequal Wilkinson power divider to 7:1 and reduced the size of a stepped impedance low

  11. Point Cloud Oriented Shoulder Line Extraction in Loess Hilly Area

    Science.gov (United States)

    Min, Li; Xin, Yang; Liyang, Xiong

    2016-06-01

    Shoulder line is the significant line in hilly area of Loess Plateau in China, dividing the surface into positive and negative terrain (P-N terrains). Due to the point cloud vegetation removal methods of P-N terrains are different, there is an imperative need for shoulder line extraction. In this paper, we proposed an automatic shoulder line extraction method based on point cloud. The workflow is as below: (i) ground points were selected by using a grid filter in order to remove most of noisy points. (ii) Based on DEM interpolated by those ground points, slope was mapped and classified into two classes (P-N terrains), using Natural Break Classified method. (iii) The common boundary between two slopes is extracted as shoulder line candidate. (iv) Adjust the filter gird size and repeat step i-iii until the shoulder line candidate matches its real location. (v) Generate shoulder line of the whole area. Test area locates in Madigou, Jingbian County of Shaanxi Province, China. A total of 600 million points are acquired in the test area of 0.23km2, using Riegl VZ400 3D Laser Scanner in August 2014. Due to the limit Granted computing performance, the test area is divided into 60 blocks and 13 of them around the shoulder line were selected for filter grid size optimizing. The experiment result shows that the optimal filter grid size varies in diverse sample area, and a power function relation exists between filter grid size and point density. The optimal grid size was determined by above relation and shoulder lines of 60 blocks were then extracted. Comparing with the manual interpretation results, the accuracy of the whole result reaches 85%. This method can be applied to shoulder line extraction in hilly area, which is crucial for point cloud denoising and high accuracy DEM generation.

  12. POINT CLOUD ORIENTED SHOULDER LINE EXTRACTION IN LOESS HILLY AREA

    Directory of Open Access Journals (Sweden)

    L. Min

    2016-06-01

    Full Text Available Shoulder line is the significant line in hilly area of Loess Plateau in China, dividing the surface into positive and negative terrain (P-N terrains. Due to the point cloud vegetation removal methods of P-N terrains are different, there is an imperative need for shoulder line extraction. In this paper, we proposed an automatic shoulder line extraction method based on point cloud. The workflow is as below: (i ground points were selected by using a grid filter in order to remove most of noisy points. (ii Based on DEM interpolated by those ground points, slope was mapped and classified into two classes (P-N terrains, using Natural Break Classified method. (iii The common boundary between two slopes is extracted as shoulder line candidate. (iv Adjust the filter gird size and repeat step i-iii until the shoulder line candidate matches its real location. (v Generate shoulder line of the whole area. Test area locates in Madigou, Jingbian County of Shaanxi Province, China. A total of 600 million points are acquired in the test area of 0.23km2, using Riegl VZ400 3D Laser Scanner in August 2014. Due to the limit Granted computing performance, the test area is divided into 60 blocks and 13 of them around the shoulder line were selected for filter grid size optimizing. The experiment result shows that the optimal filter grid size varies in diverse sample area, and a power function relation exists between filter grid size and point density. The optimal grid size was determined by above relation and shoulder lines of 60 blocks were then extracted. Comparing with the manual interpretation results, the accuracy of the whole result reaches 85%. This method can be applied to shoulder line extraction in hilly area, which is crucial for point cloud denoising and high accuracy DEM generation.

  13. A biomechanical analysis of four sprint start positions.

    Science.gov (United States)

    Schot, P K; Knutzen, K M

    1992-06-01

    The sprint starts of 12 skilled collegiate sprinter/hurdlers were filmed for four different sprint start conditions. Ground reaction forces were collected for the first step out of the blocks and velocities through a 2-m speed trap immediately following the first support phase were recorded. The subjects employed their preferred right-left leg placement in the blocks, while the anterior-posterior spacing of the front block with respect to the starting line and the amount of forward lean in the set position were varied. Four positions were constructed that accounted for anthropometric differences. The four positions consisted of combinations of two arm orientations (forward lean and perpendicular to ground) and two front block to starting line distances (bunched and elongated). Kinematic data were reduced to provide center of mass position and velocity measures and analyzed for critical periods throughout the starting action. Selected critical events from the first step kinetic records were also analyzed. The results indicated that the elongated starting positions resulted in greater horizontal displacement, greater propelling impulse, increased first step toe-off velocity, and greater average velocity through a 2-m speed trap. Arm orientation effects were less well defined. Forward lean tended to result in greater vertical velocity at block clearance and horizontal velocity at first step toe-off, whereas perpendicular arm positioning resulted in greater 2-m speed trap velocity.

  14. Comparison of the effect of the GABAB receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats

    Science.gov (United States)

    Maccioni, Paola; Zaru, Alessandro; Loi, Barbara; Lobina, Carla; Carai, Mauro A.M.; Gessa, Gian Luigi; Capra, Alessandro; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; Hyytiä, Petri; Lumeng, Lawrence; Colombo, Giancarlo

    2012-01-01

    Background Administration of the GABAB receptor agonist, baclofen, and positive allosteric modulator (PAM), GS39783, has been repeatedly reported to suppress multiple alcohol-related behaviors, including operant oral alcohol self-administration, in rats. The present study was designed to compare the effect of baclofen and GS39783 on alcohol self-administration in three lines of selectively bred, alcohol-preferring rats: Indiana alcohol-preferring (P), Sardinian alcohol-preferring (sP), and Alko Alcohol (AA). Methods Rats of each line were initially trained to respond on a lever, on a fixed ratio (FR) 4 (FR4) schedule of reinforcement, to orally self-administer alcohol (15%, v/v) in daily 30-min sessions. Once responding reached stable levels, rats were exposed to a sequence of experiments testing baclofen (0, 1, 1.7, and 3 mg/kg; i.p.) and GS39783 (0, 25, 50, and 100 mg/kg; i.g.) on FR4 and progressive ratio (PR) schedules of reinforcement. Finally, to assess the specificity of baclofen and GS39783 action, rats were slightly food-deprived and trained to lever-respond for food pellets. Results The rank of order of the reinforcing and motivational properties of alcohol was: P>sP>AA rats. Under both FR and PR schedules of reinforcement, the rank of order of potency and efficacy of baclofen and GS39783 in suppressing alcohol self-administration was: P>sP>AA rats. Only the highest dose of baclofen reduced lever-responding for food pellets; this effect was common to all three rat lines. Conversely, no dose of GS39783 altered lever-responding for food in any rat line. Conclusions These results suggest that: (a) the strength of the reinforcing and motivational properties of alcohol differ among P, sP, and AA rats; (b) the reinforcing and motivational properties of alcohol in P, sP, and AA rats are differentially sensitive to treatment with baclofen and GS39783; (c) the heterogeneity in sensitivity to baclofen and GS39783 of alcohol self-administration in P, sP, and AA rats

  15. Steps toward determination of the size and structure of the broad-line region in active galatic nuclei. 8: An intensive HST, IUE, and ground-based study of NGC 5548

    Science.gov (United States)

    Korista, K. T.; Alloin, D.; Barr, P.; Clavel, J.; Cohen, R. D.; Crenshaw, D. M.; Evans, I. N.; Horne, K.; Koratkar, A. P.; Kriss, G. A.

    1995-01-01

    We present the data and initial results from a combined Hubble Space Telescope (HST)/IUE/ground-based spectroscopic monitoring campaign on the Seyfert 1 galaxy NGC 5548 that was undertaken in order to address questions that require both higher temporal resolution and higher signal-to-noise ratios than were obtained in our previous multiwavelength monitoring of this galaxy in 1988-1989. IUE spectra were obtained once every 2 days for a period of 74 days beginning on 1993 March 14. During the last 39 days of this campaign, spectroscopic observations were also made with the HST Faint Object Spectrograph (FOS) on a daily basis. Ground-based observations, consisting of 165 optical spectra and 77 photometric observations (both CCD imaging and aperture photometry), are reported for the period 1992 October-1993 September, although many of the data are concentrated around the time of the satellite-based program. These data constitute a fifth year of intensive optical monitoring of this galaxy. In this contribution we describe the acquisition and reduction of all of the satellite and ground-based data obtained in this program. We describe in detail various photometric problems with the FOS and explain how we identified and corrected for various anomalies.

  16. Spectroscopic measurements of a CO2 absorption line in an open vertical path using an airborne lidar

    CERN Document Server

    Ramanathan, Anand; Allan, Graham R; Riris, Haris; Weaver, Clark J; Hasselbrack, William E; Browell, Edward V; Abshire, James B

    2013-01-01

    We use an airborne pulsed integrated path differential absorption lidar to make spectroscopic measurements of the pressure-induced line broadening and line center shift of atmospheric CO2 at the 1572.335 nm absorption line. We measure the absorption lineshape in the vertical column between the aircraft and ground. A comparison of our measured absorption lineshape to calculations based on HITRAN shows excellent agreement with the peak optical depth accurate to within 0.3%. Additionally, we measure changes in the line center position to within 5.2 MHz of calculations, and the absorption linewidth to within 0.6% of calculations.

  17. Space-based monitoring of ground deformation

    Science.gov (United States)

    Nobakht Ersi, Fereydoun; Safari, Abdolreza; Gamse, Sonja

    2016-07-01

    Ground deformation monitoring is valuable to understanding of the behaviour of natural phenomena. Space-Based measurement systems such as Global Positioning System are useful tools for continuous monitoring of ground deformation. Ground deformation analysis based on space geodetic techniques have provided a new, more accurate, and reliable source of information for geodetic positioning which is used to detect deformations of the Ground surface. This type of studies using displacement fields derived from repeated measurments of space-based geodetic networks indicates how crucial role the space geodetic methods play in geodynamics. The main scope of this contribution is to monitor of ground deformation by obtained measurements from GPS sites. We present ground deformation analysis in three steps: a global congruency test on daily coordinates of permanent GPS stations to specify in which epochs deformations occur, the localization of the deformed GPS sites and the determination of deformations.

  18. Safety, pharmacokinetics and efficacy findings in an open-label, single-arm study of weekly paclitaxel plus lapatinib as first-line therapy for Japanese women with HER2-positive metastatic breast cancer.

    Science.gov (United States)

    Inoue, Kenichi; Kuroi, Katsumasa; Shimizu, Satoru; Rai, Yoshiaki; Aogi, Kenjiro; Masuda, Norikazu; Nakayama, Takahiro; Iwata, Hiroji; Nishimura, Yuichiro; Armour, Alison; Sasaki, Yasutsuna

    2015-12-01

    Lapatinib is the human epidermal growth factor receptor 2 (HER2) targeting agent approved globally for HER2-positive metastatic breast cancer (MBC). The efficacy, safety and pharmacokinetics (PK) of lapatinib combined with paclitaxel (L+P) were investigated in this study, to establish clear evidence regarding the combination in Japanese patients. In this two-part, single-arm, open-label study, the tolerability of L+P as first-line treatment in Japanese patients with HER2-positive MBC was evaluated in six patients in the first part, and the safety, efficacy and PK were evaluated in a further six patients (making a total of twelve patients) in the second part. Eligible women were enrolled and received lapatinib 1500 mg once daily and paclitaxel 80 mg/m(2) weekly for at least 6 cycles. The only dose-limiting toxicity reported was Grade 3 diarrhea in one patient. The systemic exposure to maximum plasma concentration and area under the plasma concentration curve (AUC) for lapatinib, as well as the AUC of paclitaxel, were increased when combined. The most common adverse events (AEs) related to the study treatment were alopecia, diarrhea and decreased hemoglobin. The majority of drug-related AEs were Grade 1 or 2. The median overall survival was 35.6 months (95 % confidence interval 23.9, not reached). The response rate and clinical benefit rate were both 83 % (95 % confidence interval 51.6, 97.9). The L+P treatment was well tolerated in Japanese patients with HER2-positive MBC. Although the PK profiles of lapatinib and paclitaxel influenced each other, the magnitudes were not greatly different from those in non-Japanese patients.

  19. Gene expression profile in a glioma cell line resistant to cell death induced by the chimeric tumor suppressor-1 (CTS-1), a dominant-positive variant of p53--the role of NFkappaB.

    Science.gov (United States)

    Seznec, Janina; Weit, Simone; Naumann, Ulrike

    2010-03-01

    The identification of genes involved in carcinogenesis and tumor progression is of great interest since these genes might be feasible as candidates for new tumor-targeted therapy strategies. Chimeric tumor suppressor-1 (CTS-1), an artificial synthetic variant of p53, resists common p53 inactivation and could therefore be defined as a dominant-positive p53 variant. Overexpression of CTS-1 induces caspase-independent cell death. We used whole-genome microarray expression analysis in a parental (229(P)) and a CTS-1-resistant glioma cell line (229(Res)) to analyze alterations in gene expression in Ad-CTS-1-infected and in uninfected parental and resistant cells. In total, 700 genes were differentially expressed in infected and 313 genes in uninfected 229(Res) versus 229(P) cells. Ingenuity Pathway Analysis determined a variety of differentially expressed genes in Ad-CTS-1-infected cells that were members of intracellular networks with central tumor-involved players such as nuclear factor-kappaB (NFkappaB), protein kinase B/AKT or transforming growth factor-beta. Here we focused on the function of NFkappaB in Ad-CTS-1-mediated cell death in glioma. NFkappaB was activated in Ad-CTS-1-infected 229(P) but not 229(Res) cells. NFkappaB activation was accompanied by the induction of cell death in parental cells. Inhibition of NFkappaB activity by expression of an IkappaB super repressor or upregulation of the NFkappaB-linked gene Bex protected parental cells to Ad-CTS-1-induced cell death, whereas knockdown of Bex sensitized both parental and resistant cells. Taken together, these data suggest that activation of the normally antiapoptotic protein NFkappaB does not always necessarily protect cells from apoptosis but, in the glioma cell lines tested so far, and in an environment where p53 is constitutively active, also leads to the induction of cell death.

  20. Development and application of mechanical calculation and drawing software for conducting wire and ground wire of power transmission line%送电线路导地线力学计算绘图软件的开发与应用

    Institute of Scientific and Technical Information of China (English)

    梁世党

    2012-01-01

      以开发“送电线路导地线力学计算绘图”软件为例,介绍了如何在Excel 2007中利用Visual Basic语言开发一个能快速绘制各种设计气象条件、不同导地线型号的送电线路导地线应力弧垂计算及绘图的应用程序,供工程设计人员在Excel 2007二次开发中作为参考,从而提高绘图效率。%  Taking the development of mechanical calculation and drawing software for conducting wire and ground wire of power transmission line as example, the author presented how to use Excel 2007 and Visual Basic language to develop an application software which permits rapid stress sag calculation and drawing for different types of con⁃ducting wire and ground wire of power transmission line under various meteorological conditions, aiming to provide reference for secondary development of Excel 2007 and higher drawing efficiency.

  1. Characterizing the atomic mass surface beyond the proton drip line via a-decay measurements of the s1/2 ground state of 165Re and the h11/2 isomer in 161Ta

    CERN Document Server

    O'Donnell, D; Scholey, C; Bianco, L; Capponi, L; Carroll, R J; Darby, I G; Donosa, L; Drummond, M; Ertugral, F; Greenlees, P T; Grahn, T; Hauschild, K; Herzan, A; Jakobsson, U; Jones, P; Joss, D T; Julin, R; Juutinen, S; Ketelhut, S; Labiche, M; Leino, M; Lopez-Martens, A; Mullholland, K; Nieminen, P; Peura, P; Rahkila, P; Rinta-Antila, S; Ruotsalainen, P; Sandzelius, M; Saren, J; Saygi, B; Simpson, J; Sorri, J; Thornthwaite, A; Uusitalo, J; 10.1103/PhysRevC.86.064315

    2012-01-01

    The a-decay chains originating from the s1/2 and h11/2 states in 173Au have been investigated following fusion-evaporation reactions. Four generations of a radioactivities have been correlated with 173Aum leading to a measurement of the a decay of 161Tam. It has been found that the known a decay of 161Ta, which was previously associated with the decay of the ground state, is in fact the decay of an isomeric state. This work also reports on the first observation of prompt g rays feeding the ground state of 173Au. This prompt radiation was used to aid the study of the a-decay chain originating from the s1/2 state in 173Au. Three generations of a decays have been correlated with this state leading to the observation of a previously unreported activity which is assigned as the decay of 165Reg. This work also reports the excitation energy of an a-decaying isomer in 161Ta and the Q-value of the decay of 161Tag.

  2. Comprehensive Analysis of Lightning Performance of Overhead Power Distribution Line with Varied Ground Obliquity%不同地形条件下架空配电线路的防雷分析

    Institute of Scientific and Technical Information of China (English)

    刘靖; 刘明光; 屈志坚; 刘铁

    2011-01-01

    In order to take lightning problem into consideration comprehensively, we introduced a new model for calculating the lightning outage rate of overhead power distribution line due to direct and indirect lightning strokes. By establishing an improved EGM model of overhead distribution line based on striking distance theory, combining with probability density function of lightning current, we solved the attract range of overhead line, which possesses a nonlinear relationship with line height for different district. Taking the Rusck's formula into consideration, basing on Generalized Integral method, we put forward a new arithmetic for calculating the lightning outage rate which includes indirect lightning. By calculation of two real 10 kV power distribution line, the new method is practical and accurate. The results show that indirect strokes are the main cause of lightning trip out, and for analyzing the lightning performance of overhead power distribution lines, the indirect lightning must be taken into consideration.%雷电活动直接影响到架空电力线路的安全稳定运行,为全面分析架空配电线路的雷害问题,提出了一种计入地形条件影响的分析新方法.先基于雷电的击距理论建立架空配电线路的引雷模型,结合雷电流的概率密度函数,求出了线路在不同高度和不同地形条件下的引雷范围与线路高度呈非线性关系;在确定线路引雷范围的基础上,分别计算了我国不同地域的架空线路直接雷击跳闸率;在对Rusck感应雷过电压研究成果分析的基础上,利用广义积分法得出了不同地形和地域的感应雷击跳闸率计算公式,而且架空配电线路中感应雷击跳闸次数占总雷击跳闸次数能达到83%,在架空线路的防雷分析中应该计入感应雷击的影响.2条10 kV架空线路算例与实际运行情况的对比验证了该计算方法的正确性.

  3. 零序电流比例增量法在小电流接地故障选线中的应用%Application of the zero sequence current incremental ratio method in small current grounding fault line identification

    Institute of Scientific and Technical Information of China (English)

    王新超; 张玉海

    2011-01-01

    通过对小电流接地系统电路特点的深入研究发现,故障后在各条支路上流动的零序电容电流只决定于系统的零序电压与支路的对地电容,而不决定于故障发生在哪条支路上,且故障发生前后的支路对地电容几乎不变.非故障支路上流动的是零序电容电流,故障支路上流动着的是零序电容电流与接地电流的叠加.正是基于这一分析结果提出了一种零序电流比例增量法,定义了基准零序电流比例系数序列和参考基准电流分度系数等中间参量.其工作特点是可以剥离各支路的零序电容电流,并通过比较剥离后各支路增量的最大者,即故障支路.进一步的仿真表明该法稳定可靠,具有良好的适应能力.该法对其他判别法提高判别精度也有帮助.%Intensive studying on the characteristics of small current grounding system circuit finds that the zero sequence capacitive current in each powerline depends merely on the system's zero-sequence voltage and powerline-to-ground capacitances when a single-phase grounding failure happens, and does not depend on that the failure occurrs in which powerline, and the powerline-to-ground capacitances are almost unchanged before or after the failure. Non-fault powerline currents are zero sequence capacitive currents, but fault powerline current is the zero sequence capacitance current plus the grounding current. Based on the results of this analysis a zero sequence current proportion incremental method is given, which defines some medium-parameters such as the zero sequence current ratio standard coefficient array and reference current gauge coefficient. Characteristics of the method is that zero-sequence capacitive currents are stripped, and the maximum increment of the powerline is found, which is the fault one. Further simulations show that the method is stable and reliable, with good adaptability. The method can also improve identification accuracy of other

  4. Ground water and energy

    Energy Technology Data Exchange (ETDEWEB)

    1980-11-01

    This national workshop on ground water and energy was conceived by the US Department of Energy's Office of Environmental Assessments. Generally, OEA needed to know what data are available on ground water, what information is still needed, and how DOE can best utilize what has already been learned. The workshop focussed on three areas: (1) ground water supply; (2) conflicts and barriers to ground water use; and (3) alternatives or solutions to the various issues relating to ground water. (ACR)

  5. The LOFT Ground Segment

    CERN Document Server

    Bozzo, E; Argan, A; Barret, D; Binko, P; Brandt, S; Cavazzuti, E; Courvoisier, T; Herder, J W den; Feroci, M; Ferrigno, C; Giommi, P; Götz, D; Guy, L; Hernanz, M; Zand, J J M in't; Klochkov, D; Kuulkers, E; Motch, C; Lumb, D; Papitto, A; Pittori, C; Rohlfs, R; Santangelo, A; Schmid, C; Schwope, A D; Smith, P J; Webb, N A; Wilms, J; Zane, S

    2014-01-01

    LOFT, the Large Observatory For X-ray Timing, was one of the ESA M3 mission candidates that completed their assessment phase at the end of 2013. LOFT is equipped with two instruments, the Large Area Detector (LAD) and the Wide Field Monitor (WFM). The LAD performs pointed observations of several targets per orbit (~90 minutes), providing roughly ~80 GB of proprietary data per day (the proprietary period will be 12 months). The WFM continuously monitors about 1/3 of the sky at a time and provides data for about ~100 sources a day, resulting in a total of ~20 GB of additional telemetry. The LOFT Burst alert System additionally identifies on-board bright impulsive events (e.g., Gamma-ray Bursts, GRBs) and broadcasts the corresponding position and trigger time to the ground using a dedicated system of ~15 VHF receivers. All WFM data are planned to be made public immediately. In this contribution we summarize the planned organization of the LOFT ground segment (GS), as established in the mission Yellow Book 1 . We...

  6. Transgenic cassava lines carrying heterologous alternative oxidase ...

    African Journals Online (AJOL)

    To screen positive lines for gene function, leaf lobes from two transgenic lines with a line carrying an empty vector and the wild type were subjected to somatic embryogenesis (SE), a known oxidative ... African Journal of Biotechnology Vol.

  7. Microwave transmission-line impedance data

    CERN Document Server

    Gunston, M A R

    1996-01-01

    A compendium of data for computing the characteristic impedance of transmission lines based on physical dimensions. Covers both conventional structures and unusual geometries, including coaxial, eccentric and elliptic coaxial, twin-wire, wire-above-ground, microstrip and derivatives, stripline, slabline and trough line. Also details numerous configurations of coupled lines.

  8. 49 CFR 192.375 - Service lines: Plastic.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Service lines: Plastic. 192.375 Section 192.375... § 192.375 Service lines: Plastic. (a) Each plastic service line outside a building must be installed... terminate above ground level and outside the building, if— (i) The above ground level part of the...

  9. Measure Lines

    Science.gov (United States)

    Crissman, Sally

    2011-01-01

    One tool for enhancing students' work with data in the science classroom is the measure line. As a coteacher and curriculum developer for The Inquiry Project, the author has seen how measure lines--a number line in which the numbers refer to units of measure--help students not only represent data but also analyze it in ways that generate…

  10. Positive Psychology and Leisure Education

    National Research Council Canada - National Science Library

    John Dattilo

    2015-01-01

      The purpose of this paper is to present a balanced and systematic leisure education service model grounded in positive psychology principles that are applied across diverse audiences and in various...

  11. GENERAL FAULT ADMITTANCE METHOD LINETO- LINE-TO-LINE UNSYMMETRICAL FAULT

    Directory of Open Access Journals (Sweden)

    J. D. SAKALA

    2015-09-01

    Full Text Available Line-to-line-to-line unsymmetrical faults either involving or not involving ground are in the classical fault analysis approach difficult to analyse. This is because the classical solution requires use of the knowledge of connection of symmetrical component sequence networks for various common faults. In this approach, the phase fault constraints are converted into symmetrical sequence constraints and the sequence networks connected in a way that satisfies the constraints. The symmetrical component constraints for an unsymmetrical three-phase fault not involving ground do not lend themselves easy to the connection of the sequence networks. The exception is that, because the phase currents at the fault summate to zero, the zero sequence current is zero and therefore the zero sequence network is not connected. The connection of the positive and negative sequence networks is difficult to deduce when the fault is unsymmetrical. A classical solution is therefore difficult to find. In contrast, a solution by the general method of fault admittance matrix does not require prior knowledge of how the sequence networks are connected. It is therefore more versatile than the classical methods. The paper presents a procedure for solving a three-phase unsymmetrical fault, with different fault impedances, hence fault admittances in each phase. A computer program based on the general fault admittance method is developed and used to analyse an unsymmetrical three-phase fault on a simple power system with a delta-earthed-star connected transformer.

  12. Research of Stop Production Line Position Based on Key Strata Theory%基于关键层理论的停采线位置确定方法研究

    Institute of Scientific and Technical Information of China (English)

    荆俊杰

    2013-01-01

    利用组合梁原理计算出井工开采过程中的关键层上部荷载,并且对关键层应力及应变进行计算,揭示了关键层断裂在下部煤层中的应力分布规律,从而提出巷道稳定判定准则,为确定回采工作面的停采线合理位置提供依据。%The use of composite beam theory to calculate the joint work well in the process of mining key layer beam top load, and the key ctrata deformation and stress calculation, it is concluded that the key layer beam fracture in the lower coal seam, the stress distribution, and then puts forward the roadway stability criterion for well work combined mining working face in line position determine reasonable stop lay the foundation.

  13. Modeling the global positioning system signal propagation through the ionosphere

    Science.gov (United States)

    Bassiri, S.; Hajj, G. A.

    1992-01-01

    Based on realistic modeling of the electron density of the ionosphere and using a dipole moment approximation for the Earth's magnetic field, one is able to estimate the effect of the ionosphere on the Global Positioning System (GPS) signal for a ground user. The lowest order effect, which is on the order of 0.1-100 m of group delay, is subtracted out by forming a linear combination of the dual frequencies of the GPS signal. One is left with second- and third-order effects that are estimated typically to be approximately 0-2 cm and approximately 0-2 mm at zenith, respectively, depending on the geographical location, the time of day, the time of year, the solar cycle, and the relative geometry of the magnetic field and the line of sight. Given the total electron content along a line of sight, the authors derive an approximation to the second-order term which is accurate to approximately 90 percent within the magnetic dipole moment model; this approximation can be used to reduce the second-order term to the millimeter level, thus potentially improving precise positioning in space and on the ground. The induced group delay, or phase advance, due to second- and third-order effects is examined for two ground receivers located at equatorial and mid-latitude regions tracking several GPS satellites.

  14. Laboratory Investigation on Lightning Flashes to High Voltage Transmission Lines%Laboratory Investigation on Lightning Flashes to High Voltage Transmission Lines

    Institute of Scientific and Technical Information of China (English)

    Thongchai Disyadej; Stanislaw Grzybowski

    2011-01-01

    This paper presents an investigation on the attractive width of high voltage transmission lines to lightning strikes. In order to design the optimal lightning protection, the estimated number of lightning flashes on the line, which is based on its attractive width, needs to be determined. The investigation was performed using experiments with model tests at the Mississippi State University High Voltage Laboratory. For laboratory experiments, a total of 2,100 negative and positive switching impulse voltages were applied to transmission line models from a conducting rod, which represented a lightning downward leader. Different tested models of transmission lines on a scale of 1:100 were used. The effects of overhead ground wires, phase conductors, tower structures, and the magnitude and polarity of lightning strokes were also studied. The attractive width increased gradually with the height of overhead ground wires and towers as well as the magnitude of the lightning stroke current. Impulse polarity had an impact on the at- tractive width, and the attractive width for negative polarity was larger than that {or positive polarity. The taller tower had more effect on flash distribution to transmission lines than the shorter one. The experimental results agree with the actual transmission line observations published in literature. The new expressions for the attractive width of transmission lines, based on the experimental results, were established. The accurate estimation of the attractive width can help electric power utilities plan transmission systems reliably and economically. The detailed description of the back- ground problem, proposed method, experimental results, and analysis are presented in this paper.

  15. Establishment and Identification of A New HPV Positive Esophageal Cancer Cell Line%一株人乳头瘤病毒阳性的新的食管癌细胞系的建立及鉴定

    Institute of Scientific and Technical Information of China (English)

    李劲涛; 周福有; 董温平; 王立东; 曾毅

    2013-01-01

    In order to explore the relationship between human papilloma virus ( HPV) and upper gastrointestinal cancer(esophageal cancer), An esophageal squamous cell carcinoma(ESCC) tissue was obtained from a 76 year old Chinese female patient from Anyang city, a high-incidence area for esophageal cancer, in China. Transplanted tumor was formed through direct SCID mouse tumorigenicity experiment and cultured monolayer cells were obtained after several passages and screenings Immunofluorescence test, cell growth curve, soft agar assay, chromosome analysis and tissues HE staining were also performed to confirm the epithelial cell origin. Cell DNA STR typing results showed that no three alleles was observed,indicating no contamination of human cells. DNA analysis revealed the presence of HPV type 18 DNA in this cell line. DOLINK test found the E6 protein expression of HPV virus. We concluded that the established cell line is a new esophageal squamous cell-origincarcinoma cell line with HPV DNA positive and expression of viral oncoprotein. It provides new cytologic material for performing etiology studies on the occurrence and development of esophageal cancer.%为了探讨人乳头瘤病毒(Human papillomavirus,HPV)与上消化道肿瘤食管癌关系,从食管癌高发区安阳市取到一例76岁的中国女性食管鳞癌患者肿瘤组织.通过直接SCID小鼠致瘤实验,可长成移植瘤.取出组织做组织培养并多次纯化传代筛选后,成均一单层细胞.分别进行免疫荧光,细胞生长曲线,软琼脂鉴定,染色体分析,细胞致瘤实验及瘤体切片HE染色等确定是上皮细胞来源的癌细胞.利用细胞STR分型结果显示,基因座均未出现三等位基因现象,无人类细胞交叉污染.对细胞DNA分析发现存在HPV18型的DNA.利用蛋白检测实验发现有HPV病毒癌蛋白表达.结果表明,所建细胞株为有HPV核酸存在并能表达病毒癌蛋白的新的食管鳞癌细胞株.为我们进行食管癌的发生发

  16. Data analysis of photon beam position at PLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Ko, J.; Shin, S., E-mail: tlssh@postech.ac.kr; Huang, Jung-Yun; Kim, D.; Kim, C.; Kim, Ilyou; Lee, T.-Y.; Park, C.-D.; Kim, K. R. [Pohang Accelerator Laboratory, Pohang, Kyungbuk 790-834 (Korea, Republic of); Cho, Moohyun [Department of Physics, POSTECH, Pohang, Kyungbuk 790-834 (Korea, Republic of)

    2016-07-27

    In the third generation light source, photon beam position stability is critical issue on user experiment. Generally photon beam position monitors have been developed for the detection of the real photon beam position and the position is controlled by feedback system in order to keep the reference photon beam position. In the PLS-II, photon beam position stability for front end of particular beam line, in which photon beam position monitor is installed, has been obtained less than rms 1μm for user service period. Nevertheless, detail analysis for photon beam position data in order to demonstrate the performance of photon beam position monitor is necessary, since it can be suffers from various unknown noises. (for instance, a back ground contamination due to upstream or downstream dipole radiation, undulator gap dependence, etc.) In this paper, we will describe the start to end study for photon beam position stability and the Singular Value Decomposition (SVD) analysis to demonstrate the reliability on photon beam position data.

  17. A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer.

    Science.gov (United States)

    Malorni, Luca; Piazza, Silvano; Ciani, Yari; Guarducci, Cristina; Bonechi, Martina; Biagioni, Chiara; Hart, Christopher D; Verardo, Roberto; Di Leo, Angelo; Migliaccio, Ilenia

    2016-09-13

    Palbociclib is a CDK4/6 inhibitor that received FDA approval for treatment of hormone receptor positive (HR+) HER2 negative (HER2neg) advanced breast cancer. To better personalize patients treatment it is critical to identify subgroups that would mostly benefit from it. We hypothesize that complex alterations of the Retinoblastoma (Rb) pathway might be implicated in resistance to CDK4/6 inhibitors and aim to investigate whether signatures of Rb loss-of-function would identify breast cancer cell lines resistant to palbociclib. We established a gene expression signature of Rb loss-of-function (RBsig) by identifying genes correlated with E2F1 and E2F2 expression in breast cancers within The Cancer Genome Atlas. We assessed the RBsig prognostic role in the METABRIC and in a comprehensive breast cancer meta-dataset. Finally, we analyzed whether RBsig would discriminate palbociclib-sensitive and -resistant breast cancer cells in a large RNA sequencing-based dataset. The RBsig was associated with RB1 genetic status in all tumors (p <7e-32) and in luminal or basal subtypes (p < 7e-11 and p < 0.002, respectively). The RBsig was prognostic in the METABRIC dataset (discovery: HR = 1.93 [1.5-2.4] p = 1.4e-08; validation: HR = 2.01 [1.6-2.5] p = 1.3e-09). Untreated and endocrine treated patients with estrogen receptor positive breast cancer expressing high RBsig had significantly worse recurrence free survival compared to those with low RBsig (HR = 2.37 [1.8 - 3.2] p = 1.87e-08 and HR = 2.62 [1.9- 3.5] p = 8.6e-11, respectively). The RBsig was able to identify palbociclib resistant and sensitive breast cancer cells (ROC AUC = 0,7778). Signatures of RB loss might be helpful in personalizing treatment of patients with HR+/HER2neg breast cancer. Further validation in patients receiving palbociclib is warranted.

  18. A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer

    Science.gov (United States)

    Malorni, Luca; Piazza, Silvano; Ciani, Yari; Guarducci, Cristina; Bonechi, Martina; Biagioni, Chiara; Hart, Christopher D.; Verardo, Roberto; Leo, Angelo Di; Migliaccio, Ilenia

    2016-01-01

    Palbociclib is a CDK4/6 inhibitor that received FDA approval for treatment of hormone receptor positive (HR+) HER2 negative (HER2neg) advanced breast cancer. To better personalize patients treatment it is critical to identify subgroups that would mostly benefit from it. We hypothesize that complex alterations of the Retinoblastoma (Rb) pathway might be implicated in resistance to CDK4/6 inhibitors and aim to investigate whether signatures of Rb loss-of-function would identify breast cancer cell lines resistant to palbociclib. We established a gene expression signature of Rb loss-of-function (RBsig) by identifying genes correlated with E2F1 and E2F2 expression in breast cancers within The Cancer Genome Atlas. We assessed the RBsig prognostic role in the METABRIC and in a comprehensive breast cancer meta-dataset. Finally, we analyzed whether RBsig would discriminate palbociclib-sensitive and -resistant breast cancer cells in a large RNA sequencing-based dataset. The RBsig was associated with RB1 genetic status in all tumors (p <7e-32) and in luminal or basal subtypes (p < 7e-11 and p < 0.002, respectively). The RBsig was prognostic in the METABRIC dataset (discovery: HR = 1.93 [1.5-2.4] p = 1.4e-08; validation: HR = 2.01 [1.6-2.5] p = 1.3e-09). Untreated and endocrine treated patients with estrogen receptor positive breast cancer expressing high RBsig had significantly worse recurrence free survival compared to those with low RBsig (HR = 2.37 [1.8 − 3.2] p = 1.87e−08 and HR = 2.62 [1.9− 3.5] p = 8.6e−11, respectively). The RBsig was able to identify palbociclib resistant and sensitive breast cancer cells (ROC AUC = 0,7778). Signatures of RB loss might be helpful in personalizing treatment of patients with HR+/HER2neg breast cancer. Further validation in patients receiving palbociclib is warranted. PMID:27634906

  19. Clinical grade expansion of CD45RA, CD45RO, and CD62L-positive T-cell lines from HLA-compatible donors: high cytotoxic potential against AML and ALL cells.

    Science.gov (United States)

    Barbui, Anna M; Borleri, Gianmaria; Conti, Elena; Ciocca, Alice; Salvi, Anna; Micò, Caterina; Introna, Martino; Rambaldi, Alessandro

    2006-04-01

    Identification of a clinical grade method for the ex vivo generation of donor-derived T cells cytotoxic against both myeloid and lymphoblastic cells still remains elusive. We investigated rapid generation and expansion of donor derived-allogeneic T-cell lines cytotoxic against patient leukemic cells. Acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL) blasts were cultured 5 days in Stem Span, granulocyte macrophage colony-stimulating factor, interleukin-4, and calcium ionophore. All B-precursor ALL (N22) and AML (N13), but not T-cell ALL (N3), differentiated into mature leukemia-derived antigen-presenting cells (LD-APC). All but one LD-APC generated cytotoxic T lymphocyte (CTL) from adult human leukocyte antigen (HLA)-identical (N8) or unrelated donors (N2). Upon in vitro culture, donor-derived CTL acquired a memory T phenotype, showing concomitant high CD45RA, CD45RO, CD62L expression. CD8(+) cells, but not CD4(+) cells, were granzyme, perforine, and interferon-gamma-positive. Pooled CD4(+) and CD8(+) cells were cytotoxic against leukemic blasts (32%, 30:1 E:T ratio), but not against autologous or patient-derived phytohemagglutinin blasts. LD-APC from five ALL patients were used to generate CTL from cord blood. A mixed population of CD4(+) and CD8(+) cells was documented in 54% of wells. T cells acquired classical effector memory phenotype and showed a higher cytotoxicity against leukemia blasts (47%, 1:1 E:T ratio). Adult and cord blood CTL showed a skewing from a complete T-cell receptor repertoire to an oligo-clonal/clonal pattern. Availability of these cells should allow clinical trials for salvage treatment of leukemia patients relapsing after allogeneic stem cell transplantation.

  20. How Service Innovation Boosts Bottom Lines

    National Research Council Canada - National Science Library

    Claude Legrand; Rob LaJoie

    2013-01-01

      In the national quest for ground-breaking R&D discoveries and inventions, service innovation is frequently ignored at considerable cost to an organization's bottom line and a nation's productivity...

  1. Advanced optical delay line demonstrator

    NARCIS (Netherlands)

    Dool, T.C. van den; Kamphues, F.G.; Fouss, B.; Henrioulle, K.; Hogenhuis, H.

    2004-01-01

    TNO TPD, in cooperation with Micromega-Dynamics and Dutch Space, has designed an advanced Optical Delay Line (ODL) for use in future ground based and space interferometry missions. The work is performed under NIVR contract in preparation for GENIE and DARWIN. Using the ESO PRIMA DDL requirements as

  2. A New Method of Ground Fault Location in 2 × 25 kV Railway Power Supply Systems

    Directory of Open Access Journals (Sweden)

    Jesús Serrano

    2017-03-01

    Full Text Available Owing to the installation of autotransformers at regular intervals along the line, distance protection relays cannot be used with the aim of locating ground faults in 2 × 25 kV railway power supply systems. The reason is that the ratio between impedance and distance to the fault point is not linear in these electrification systems, unlike in 1 × 25 kV power systems. Therefore, the location of ground faults represents a complicated task in 2 × 25 kV railway power supply systems. Various methods have been used to localize the ground fault position in 2 × 25 kV systems. The method described here allows the location of a ground fault to be economically found in an accurate way in real time, using the modules of the circulating currents in different autotransformers when the ground fault occurs. This method first needs to know the subsection and the conductor (catenary or feeder with the defect, then localizes the ground fault’s position.

  3. ExoMol line list - XXI. Nitric Oxide (NO)

    Science.gov (United States)

    Wong, Andy; Yurchenko, Sergei N.; Bernath, Peter; Müller, Holger S. P.; McConkey, Stephanie; Tennyson, Jonathan

    2017-09-01

    Line lists for the X 2Π electronic ground state for the parent isotopologue of nitric oxide (14N16O) and five other major isotopologues (14N17O, 14N18O, 15N16O, 15N17O and 15N18O) are presented. The line lists are constructed using empirical energy levels (and line positions) and high-level ab initio intensities. The energy levels were obtained using a combination of two approaches, from an effective Hamiltonian and from solving the rovibronic Schrödinger equation variationally. The effective Hamiltonian model was obtained through a fit to the experimental line positions of NO available in the literature for all six isotopologues using the programs spfit and spcat. The variational model was built through a least squares fit of the ab initio potential and spin-orbit curves to the experimentally derived energies and experimental line positions of the main isotopologue only using the duo program. The ab initio potential energy, spin-orbit and dipole moment curves (PEC, SOC and DMC) are computed using high-level ab initio methods and the marvel method is used to obtain energies of NO from experimental transition frequencies. The line lists are constructed for each isotopologue based on the use of the most accurate energy levels and the ab initio DMC. Each line list covers a wavenumber range from 0 to 40 000 cm-1 with approximately 22 000 rovibronic states and 2.3-2.6 million transitions extending to Jmax = 184.5 and vmax = 51. Partition functions are also calculated up to a temperature of 5000 K. The calculated absorption line intensities at 296 K using these line lists show excellent agreement with those included in the HITRAN and HITEMP data bases. The computed NO line lists are the most comprehensive to date, covering a wider wavenumber and temperature range compared to both the HITRAN and HITEMP data bases. These line lists are also more accurate than those used in HITEMP. The full line lists are available from the CDS http://cdsarc.u-strasbg.fr and ExoMol www

  4. 互感线路接地距离保护定值灵敏度影响分析及其整定优化%Sensitivity Impact Analysis and Optimal Setting of Grounding Distance Protection of Transmission Lines with Mutual Inductance

    Institute of Scientific and Technical Information of China (English)

    邱建; 曾耿晖; 李一泉; 陈志光; 屠卿瑞; 张葆红

    2015-01-01

    A complete detecting impedance analysis model of transmission lines with mutual inductance is developed from the angle of setting.In the model,the influence mechanism of various factors on the measured impendence of grounding distance protection is qualitatively analyzed and quantitatively validated.With these results,the conditions for the simplified model which can calculate the extreme values of the measured impendence are proposed.On this basis and by referring to typical extreme value cases in the power system,the sideline current addition influence of the detecting impendence of transmission lines with mutual inductance is further analyzed.Finally,the optimal relay setting strategy for the grounding distance protection based on the analysis results is proposed.The strategy is implemented in Guangdong power grid.Actual application results show that the optimal strategy is able to improve the adaptability and performance of grounding distance protection.%从整定的角度建立互感线路感受阻抗分析完整模型,并对模型中各因素影响互感线路接地距离保护测量阻抗的机理进行定性分析和定量验证,提出了求取测量阻抗极值的简化模型条件。在此基础上结合电网中典型极值工况进一步对互感线路感受阻抗的助增影响进行分析。最后,根据分析结论提出了接地距离保护定值的整定优化策略,该整定策略已在广东电网全面应用,实际应用结果表明该整定策略能够提高接地距离保护定值的适应性,改善了接地距离保护定值的性能。

  5. Optimal Centroid Position Estimation

    Energy Technology Data Exchange (ETDEWEB)

    Candy, J V; McClay, W A; Awwal, A S; Ferguson, S W

    2004-07-23

    The alignment of high energy laser beams for potential fusion experiments demand high precision and accuracy by the underlying positioning algorithms. This paper discusses the feasibility of employing online optimal position estimators in the form of model-based processors to achieve the desired results. Here we discuss the modeling, development, implementation and processing of model-based processors applied to both simulated and actual beam line data.

  6. 电子设备的接地和接地设计%Ground and Ground Design for Electronic Equipment

    Institute of Scientific and Technical Information of China (English)

    丁小东

    2001-01-01

    从电子设备的安全性和可靠性出发,论述了接地的重要性,并从接地类型、地线作用、接地设计等几方面介绍了有关接地技术的理论及应用。%This essay from electronic equipment of safe and reliability Start, Expound ground of significant, And from ground trpy. ground Line action. Design for ground etc. Servile aspects to introduce have Ground technique of basic knowledge. Basic theory and basic put to use.

  7. Temperature and energy deficit in the ground during operation and recovery phases of closed-loop ground source heat pump system: Effect of the groundwater flow

    Science.gov (United States)

    Erol, Selcuk; Francois, Bertrand

    2016-04-01

    The advection/dispersion mechanism of the groundwater flow in the ground has a significant effect on a borehole heat exchanger (BHE) to enhance its thermal performance. However, the amount of energy extracted from the ground never disappears and only shifts with the magnitude of the effective thermal velocity in the infinite domain. In this work, we focus on the temperature and the energy balance of the ground in an advection/dispersion dominated heat transfer system during the operation period of a BHE and the subsequent recovery phase when the system is idle. The problem is treated with single BHE and multi-BHEs systems, for different representative geology and different groundwater flow velocity. In order to assess the thermal energy deficit due to heat extraction from the ground, we used the finite line source analytical model, developed recently (Erol et al., 2015) that provides the temperature distributions around the boreholes for discontinuous heat extraction. The model is developed based on the Green's function, which is the solution of heat conduction/advection/dispersion equation in porous media, for discontinuous heat extraction by analytically convoluting rectangular function or pulses in time domain. The results demonstrate the significant positive impact of the groundwater flow for the recovery in terms of temperature deficit at the location of the borehole. However, the total thermal energy deficit is not affected by the groundwater movement. The energy balance of the ground is the same no matter the prevailing heat transfer system, which can be only conduction or advection/dispersion. In addition, the energy balance of the ground is not based on either the duration of the production period operation or of the recovery phase, but depends on the total amount of heat that is extracted and on the bulk volumetric heat capacity of the ground.

  8. 中西太平洋长鳍金枪鱼(Thunnus alalunga)延绳钓渔场分布的时空变化%The Spatio-Temporal Changes in the Long-Line Fishing Grounds of Albacore (Thunnus alalunga) in Western and Central Pacific Ocean

    Institute of Scientific and Technical Information of China (English)

    唐衍力; 徐湛

    2015-01-01

    Albacore (Thunnus alalunga) is an important economic fish species in the long-line tuna fisheries in western and central Pacific Ocean, and it is also one of the major species that the Chinese long-line fleets target in this area. To explore the spatio–temporal changes in the fishing grounds of albacore and provide guidance to the long-line fishery practice, we studied the relationship between the catch per unit effort(CPUE), the monthly catch and the sea surface temperature(SST), and analyzed the geographical changes in the fishing grounds using the frequentness accumulation method. The statistical analysis was based on the data collected from 10 albacore long-line fishing vessels of China National Fisheries Corporation (CNFC) from Feb. 2011 to Jan. 2012, combined with the environmental factors such as the SST. The results showed that in western and central Pacific Ocean, the temperature at the depth of 200 m and 150 m remained stable in a year but SST fluctuated dramatically and thus had great effects on the distribution of fishing grounds and CPUE. In a year (Feb. 2011 to Jan. 2012) the fishing ground moved periodically from 14°S to 26°S then back to 14°S. To the north of 20°S the fishing ground existed all year long, and the high catch and high CPUE were present in the area where SST was 28–29℃. To the south of 23°S the fishing ground only existed from May to August because the adverse weather conditions in other months imperiled the fishing vessels, and the high catch and high CPUE were present in the area where SST was 22–24℃. In this time window the catch accounted for 27.6% of the yearly total catch while the fishing vessels worked for only 14.4% of the yearly total fishing days. Given the enhanced anti-wind and anti-wave features of fishing vessels and gears, a new sustainable fishing ground of albacore could be explored and exploited to the south of 25°S.%为提高中西太平洋金枪鱼延绳钓渔业作业效率和应对多变的渔业

  9. High Line

    DEFF Research Database (Denmark)

    Kiib, Hans

    2015-01-01

    At just over 10 meters above street level, the High Line extends three kilometers through three districts of Southwestern Manhattan in New York. It consists of simple steel construction, and previously served as an elevated rail line connection between Penn Station on 34th Street and the many....... The High Line project has been carried out as part of an open conversion strategy. The result is a remarkable urban architectural project, which works as a catalyst for the urban development of Western Manhattan. The greater project includes the restoration and reuse of many old industrial buildings...... in close proximity to the park bridge and new projects being added to fit the context. The outcome is a conglomeration of non-contemporary urban activities along the High Line, where mechanical workshops, small wholesale stores. etc. mix with new exclusive residential buildings, eminent cafés...

  10. High Line

    DEFF Research Database (Denmark)

    Kiib, Hans

    2015-01-01

    in close proximity to the park bridge and new projects being added to fit the context. The outcome is a conglomeration of non-contemporary urban activities along the High Line, where mechanical workshops, small wholesale stores. etc. mix with new exclusive residential buildings, eminent cafés......At just over 10 meters above street level, the High Line extends three kilometers through three districts of Southwestern Manhattan in New York. It consists of simple steel construction, and previously served as an elevated rail line connection between Penn Station on 34th Street and the many...... factories and warehouses on Gansevoort Street. Today the High Line is a beautiful park covered with new tiles, viewing platforms and smaller recreational areas. The park bridge has simple, uniform, urban fittings and features a variety of flowering plants, grasses, shrubs and trees from around the world...

  11. Building Grounded Theory in Entrepreneurship Research

    DEFF Research Database (Denmark)

    Mäkelä, Markus; Turcan, Romeo V.

    2007-01-01

    In this chapter we describe the process of building of theory from data (Glaser and Strauss 1967; Strauss and Corbin 1998). We discuss current grounded theory in relation to research in entrepreneurship and point out directions and potential improvements for further research in this field...... our approach to grounded theory, we acknowledge the existence of other approaches and try to locate our approach in relation to them. As an important part of this discussion, we take a stand on how to usefully define ‘grounded theory’ and ‘case study research’. Second, we seek to firmly link our....... The chapter has two goals. First, we wish to provide an explicit paradigmatic positioning of the grounded theory methodology, discussing the most relevant views of ontology and epistemology that can be used as alternative starting points for conducting grounded theory research. While the chapter introduces...

  12. Airport Ground Staff Scheduling

    DEFF Research Database (Denmark)

    Clausen, Tommy

    travels safely and efficiently through the airport. When an aircraft lands, a significant number of tasks must be performed by different groups of ground crew, such as fueling, baggage handling and cleaning. These tasks must be complete before the aircraft is able to depart, as well as check......-in and security services. These tasks are collectively known as ground handling, and are the major source of activity with airports. The business environments of modern airports are becoming increasingly competitive, as both airports themselves and their ground handling operations are changing to private...... ownership. As airports are in competition to attract airline routes, efficient and reliable ground handling operations are imperative for the viability and continued growth of both airports and airlines. The increasing liberalization of the ground handling market prompts ground handling operators...

  13. [Introduction to grounded theory].

    Science.gov (United States)

    Wang, Shou-Yu; Windsor, Carol; Yates, Patsy

    2012-02-01

    Grounded theory, first developed by Glaser and Strauss in the 1960s, was introduced into nursing education as a distinct research methodology in the 1970s. The theory is grounded in a critique of the dominant contemporary approach to social inquiry, which imposed "enduring" theoretical propositions onto study data. Rather than starting from a set theoretical framework, grounded theory relies on researchers distinguishing meaningful constructs from generated data and then identifying an appropriate theory. Grounded theory is thus particularly useful in investigating complex issues and behaviours not previously addressed and concepts and relationships in particular populations or places that are still undeveloped or weakly connected. Grounded theory data analysis processes include open, axial and selective coding levels. The purpose of this article was to explore the grounded theory research process and provide an initial understanding of this methodology.

  14. 配网馈线自动化开关安装位置及保护定值整定探讨%Discussion on the Installation Position of Automatic Switch of the Feeder Line of Distribution Network and Protection Setting

    Institute of Scientific and Technical Information of China (English)

    王荣; 喻亮亮; 龚宇亮; 陈天一

    2014-01-01

    This paper discussed and analyzed the instal ation position of automatic switch of the feeder line, at the same time, analyzing the numerical set ing protection of the relay of the automatic switch of feeder line, hoping to provide a refe-rence for the instal ation and running of the installation po-sition of automatic switch of the feeder line of distribution ne-twork.%本文对馈线自动化开关安装位置进行了探讨与分析,同时对馈线上的自动化开关继电保护定值整定进行了分析,希望能为配网馈线自动化开关的安装及运行提供参考。

  15. Ground Vehicle Robotics

    Science.gov (United States)

    2013-08-20

    Ground Vehicle Robotics Jim Parker Associate Director, Ground Vehicle Robotics UNCLASSIFIED: Distribution Statement A. Approved for public...DATE 20 AUG 2013 2. REPORT TYPE Briefing Charts 3. DATES COVERED 09-05-2013 to 15-08-2013 4. TITLE AND SUBTITLE Ground Vehicle Robotics 5a...Willing to take Risk on technology -User Evaluated -Contested Environments -Operational Data Applied Robotics for Installation & Base Ops -Low Risk

  16. Study on Control Standard of Ground Surface Settlement of Shallow -burying and Under-excavating Tunnel Based on Smoothness of Existing Line%基于既有线平顺性浅埋暗挖隧道地面沉降控制标准

    Institute of Scientific and Technical Information of China (English)

    尚淑萍; 胡玉娇; 徐彦妮

    2014-01-01

    以西安地铁4号线下穿西安铁路站场咽喉区为例,从隧道施工引起的地层变位的一般规律出发,根据隧道施工地面沉降经典 Peck 法,基于既有线的平顺性,依据规范规定的既有线路的允许偏差值,应用数学力学的基本分析方法,分析了隧道施工对既有线路的影响及浅埋暗挖隧道施工对铁路站场的路线影响,系统地建立浅埋暗挖隧道施工地表沉降控制标准,为地铁隧道工程的资金投入和施工方案、加固方案的选取提供依据。%Taking Xi’an Underground Railway No .4 Line which crosses below Xi’an Station for example ,according to the general deformation regulation in tunnel construction and the classical Peak Method ,and based on the smoothness and the permissible deviation of existing lines ,the impacts of tunnel construction on existing lines and railway stations are an -alyzed ,and the control standard for the ground surface settlement in shallow-burying and under-excavating tunnel con-struction is estabilished by using basic mathematic and mechanical analysis methods ,which could provide some references for the fund investment of metro tunnel engineerings and the selecting of construction and reinforcement schemes .

  17. Position Information

    Data.gov (United States)

    Social Security Administration — The Position Information Data Asset provides the ability to search for active SSA position descriptions using various search criteria. An individual may search by PD...

  18. The Grounded Theory Bookshelf

    Directory of Open Access Journals (Sweden)

    Vivian B. Martin, Ph.D.

    2005-03-01

    Full Text Available Bookshelf will provide critical reviews and perspectives on books on theory and methodology of interest to grounded theory. This issue includes a review of Heaton’s Reworking Qualitative Data, of special interest for some of its references to grounded theory as a secondary analysis tool; and Goulding’s Grounded Theory: A practical guide for management, business, and market researchers, a book that attempts to explicate the method and presents a grounded theory study that falls a little short of the mark of a fully elaborated theory.Reworking Qualitative Data, Janet Heaton (Sage, 2004. Paperback, 176 pages, $29.95. Hardcover also available.

  19. Grounded theory, feminist theory, critical theory: toward theoretical triangulation.

    Science.gov (United States)

    Kushner, Kaysi Eastlick; Morrow, Raymond

    2003-01-01

    Nursing and social science scholars have examined the compatibility between feminist and grounded theory traditions in scientific knowledge generation, concluding that they are complementary, yet not without certain tensions. This line of inquiry is extended to propose a critical feminist grounded theory methodology. The construction of symbolic interactionist, feminist, and critical feminist variants of grounded theory methodology is examined in terms of the presuppositions of each tradition and their interplay as a process of theoretical triangulation.

  20. Positive Psychology

    Science.gov (United States)

    Peterson, Christopher

    2009-01-01

    Positive psychology is a deliberate correction to the focus of psychology on problems. Positive psychology does not deny the difficulties that people may experience but does suggest that sole attention to disorder leads to an incomplete view of the human condition. Positive psychologists concern themselves with four major topics: (1) positive…

  1. 29 CFR 1926.954 - Grounding for protection of employees.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Power Transmission and... the new lines or equipment. (c) Communication conductors. Bare wire communication conductors on power... operation of protective devices. (i) Grounding to tower. Grounding to tower shall be made with a tower...

  2. Ubiquitous positioning

    CERN Document Server

    Mannings, Robin

    2008-01-01

    This groundbreaking resource offers a practical, in-depth understanding of Ubiquitous Positioning - positioning systems that identify the location and position of people, vehicles and objects in time and space in the digitized networked economy. The future and growth of ubiquitous positioning will be fueled by the convergence of many other areas of technology, from mobile telematics, Internet technology, and location systems, to sensing systems, geographic information systems, and the semantic web. This first-of-its-kind volume explores ubiquitous positioning from a convergence perspective, of

  3. Science, values, and common ground.

    Science.gov (United States)

    Cuomo, Chris

    2003-11-01

    In this paper, I argue that there may be common ground shared by animal science and its critics insofar as animal scientists seek improvement in their field in four areas: the quality of their products, the quality of life for those who make their livelihood in food production, the fair treatment of human workers, and the humane treatment of animals. I also propose that there are fundamental differences between improvement motivated by profit and improvement motivated by ethical values. Positive moral change is sometimes revolutionary, although it is often a matter of promoting positive incremental changes and keeping one's attention on the effects of actions and attitudes. In conclusion, I suggest that in animal agriculture, positive change can be brought about by "getting closer" to the objects of scientific research, including nonhuman animals, by paying more attention to their welfare.

  4. Positioning consumption

    DEFF Research Database (Denmark)

    Halkier, Bente; Keller, Margit

    2014-01-01

    positionings emerges based on empirical examples of research in parent–children consumption. Positionings are flexible discursive fixations of the relationship between the performances of the practitioner, other practitioners, media discourse and consumption activities. The basic positioning types...... are the practice maintenance and the practice change position, with different sorts of adapting in between. Media discourse can become a resource for a resistant position against social control or for an appropriating position in favour of space for action. Regardless of the current relation to a particular media...... discourse, practitioners attempt to maintain their self-positioning of competence when performing. This leads us, as researchers, to caution against any a priori anticipation of the anchoring power of media discourses within everyday activities....

  5. A New Defected Ground Structure for Different Microstrip Circuit Applications

    Directory of Open Access Journals (Sweden)

    S. Das

    2007-04-01

    Full Text Available In this paper, a microstrip transmission line combined with a new U-headed dumb-bell defected ground structure (DGS is investigated. The proposed DGS of two U-shape slots connected by a thin transverse slot is placed in the ground plane of a microstrip line. A finite cutoff frequency and attenuation pole is observed and thus, the equivalent circuit of the DGS unit can be represented by a parallel LC resonant circuit in series with the transmission line. A two-cell DGS microstrip line yields a better lowpass filtering characteristics. The simulation is carried out by the MoM based IE3D software and in the experimental measurements a vector network analyzer is used. The effects of the transverse slot width and the distance between arms of the U-slot on the filter response curve are studied. This DGS is utilized for different microstrip circuit applications. The DGS is placed in the ground of a capacitive loaded microstrip line and a very low cutoff frequency is obtained. The DGS is adopted under the coupled lines of a parallel line coupler and an improvement in coupling coefficient is noticed. The proposed DGS is also incorporated in the ground plane under the feed lines and the coupled lines of a bandpass filter to improve separately the stopband and passband performances.

  6. Pesticides in Ground Water

    DEFF Research Database (Denmark)

    Bjerg, Poul Løgstrup

    1996-01-01

    Review af: Jack E. Barbash & Elizabeth A. Resek (1996). Pesticides in Ground Water. Distribution trends and governing factors. Ann Arbor Press, Inc. Chelsea, Michigan. pp 588.......Review af: Jack E. Barbash & Elizabeth A. Resek (1996). Pesticides in Ground Water. Distribution trends and governing factors. Ann Arbor Press, Inc. Chelsea, Michigan. pp 588....

  7. Pesticides in Ground Water

    DEFF Research Database (Denmark)

    Bjerg, Poul Løgstrup

    1996-01-01

    Review af: Jack E. Barbash & Elizabeth A. Resek (1996). Pesticides in Ground Water. Distribution trends and governing factors. Ann Arbor Press, Inc. Chelsea, Michigan. pp 588.......Review af: Jack E. Barbash & Elizabeth A. Resek (1996). Pesticides in Ground Water. Distribution trends and governing factors. Ann Arbor Press, Inc. Chelsea, Michigan. pp 588....

  8. Communication, concepts and grounding.

    Science.gov (United States)

    van der Velde, Frank

    2015-02-01

    This article discusses the relation between communication and conceptual grounding. In the brain, neurons, circuits and brain areas are involved in the representation of a concept, grounding it in perception and action. In terms of grounding we can distinguish between communication within the brain and communication between humans or between humans and machines. In the first form of communication, a concept is activated by sensory input. Due to grounding, the information provided by this communication is not just determined by the sensory input but also by the outgoing connection structure of the conceptual representation, which is based on previous experiences and actions. The second form of communication, that between humans or between humans and machines, is influenced by the first form. In particular, a more successful interpersonal communication might require forms of situated cognition and interaction in which the entire representations of grounded concepts are involved.

  9. Stochastic ground motion simulation

    Science.gov (United States)

    Rezaeian, Sanaz; Xiaodan, Sun; Beer, Michael; Kougioumtzoglou, Ioannis A.; Patelli, Edoardo; Siu-Kui Au, Ivan

    2014-01-01

    Strong earthquake ground motion records are fundamental in engineering applications. Ground motion time series are used in response-history dynamic analysis of structural or geotechnical systems. In such analysis, the validity of predicted responses depends on the validity of the input excitations. Ground motion records are also used to develop ground motion prediction equations(GMPEs) for intensity measures such as spectral accelerations that are used in response-spectrum dynamic analysis. Despite the thousands of available strong ground motion records, there remains a shortage of records for large-magnitude earthquakes at short distances or in specific regions, as well as records that sample specific combinations of source, path, and site characteristics.

  10. Ground energy coupling

    Science.gov (United States)

    Metz, P. D.

    The feasibility of ground coupling for various heat pump systems was investigated. Analytical heat flow models were developed to approximate design ground coupling devices for use in solar heat pump space conditioning systems. A digital computer program called GROCS (GRound Coupled Systems) was written to model 3-dimensional underground heat flow in order to simulate the behavior of ground coupling experiments and to provide performance predictions which have been compared to experimental results. GROCS also has been integrated with TRNSYS. Soil thermal property and ground coupling device experiments are described. Buried tanks, serpentine earth coils in various configurations, lengths and depths, and sealed vertical wells are being investigated. An earth coil used to heat a house without use of resistance heating is described.

  11. Inhibition spectrum studies of microthecin and other anhydrofructose derivatives using selected strains of Gram-positive and –negative bacteria, yeast and moulds, and investigation of the cytotoxicity of microthecin to malignant blood cell lines

    DEFF Research Database (Denmark)

    Fiskesund, R.; Thomas, L.V.; Schobert, M.

    2009-01-01

    Aims: To prepare 1,5-anhydro-d-fructose (AF) derivatives, test their microbial inhibition spectrum, and to further examine the most effective AF derivative against Pseudomonas aeruginosa and malignant blood cell lines. Methods and Results: Microthecin and nine other AF derivatives were synthesize...

  12. Ground level cosmic ray observations

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, S.A. [Tata Institute of Fundamental Research, Bombay (International Commission on Radiation Units and Measurements); Grimani, C.; Brunetti, M.T.; Codino, A. [Perugia Univ. (Italy)]|[INFN, Perugia (Italy); Papini, P.; Massimo Brancaccio, F.; Piccardi, S. [Florence Univ. (Italy)]|[INFN, Florence (Italy); Basini, G.; Bongiorno, F. [INFN, Laboratori Nazionali di Frascati, Rome (Italy); Golden, R.L. [New Mexico State Univ., Las Cruces, NM (United States). Particle Astrophysics Lab.; Hof, M. [Siegen Univ. (Germany). Fachbereich Physik

    1995-09-01

    Cosmic rays at ground level have been collected using the NMSU/Wizard - MASS2 instrument. The 17-hr observation run was made on September 9. 1991 in Fort Sumner, New Mexico, Usa. Fort Sumner is located at 1270 meters a.s.l., corresponding to an atmospheric depth of about 887 g/cm{sup 2}. The geomagnetic cutoff is 4.5 GV/c. The charge ratio of positive and negative muons and the proton to muon ratio have been determined. These observations will also be compared with data collected at a higher latitude using the same basic apparatus.

  13. Stop. Write! Writing Grounded Theory

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, PhD, Hon. PhD

    2012-06-01

    Full Text Available The message in this book, the dictum in this book, is to stop and write when the Grounded Theory (GT methodology puts you in that ready position. Stop unending conceptualization, unending data coverage, and unending listening to others who would egg you on with additional data, ideas and/or requirements or simply wait too long. I will discuss these ideas in detail. My experience with PhD candidates is that for the few who write when ready, many do not and SHOULD. Simply put, many write-up, but many more should.

  14. Ground states of linearly coupled Schrodinger systems

    Directory of Open Access Journals (Sweden)

    Haidong Liu

    2017-01-01

    Full Text Available This article concerns the standing waves of a linearly coupled Schrodinger system which arises from nonlinear optics and condensed matter physics. The coefficients of the system are spatially dependent and have a mixed behavior: they are periodic in some directions and tend to positive constants in other directions. Under suitable assumptions, we prove that the system has a positive ground state. In addition, when the L-infinity-norm of the coupling coefficient tends to zero, the asymptotic behavior of the ground states is also obtained.

  15. Positive Psychotherapy

    Science.gov (United States)

    Seligman, Martin E. P.; Rashid, Tayyab; Parks, Acacia C.

    2006-01-01

    Positive psychotherapy (PPT) contrasts with standard interventions for depression by increasing positive emotion, engagement, and meaning rather than directly targeting depressive symptoms. The authors have tested the effects of these interventions in a variety of settings. In informal student and clinical settings, people not uncommonly reported…

  16. Positioning Agility

    Science.gov (United States)

    Oza, Nilay; Abrahamsson, Pekka; Conboy, Kieran

    Agile methods are increasingly adopted by European companies. Academics too are conducting numerous studies on different tenets of agile methods. Companies often feel proud in marketing themselves as ‘agile’. However, the true notion of ‘being agile’ seems to have been overlooked due to lack of positioning of oneself for agility. This raises a call for more research and interactions between academia and the industry. The proposed workshop refers to this call. It will be highly relevant to participants, interested in positioning their company’s agility from organizational, group or project perspectives. The positioning of agility will help companies to better align their agile practices with stakeholder values. Results of the workshop will be shared across participants and they will also have opportunity to continue their work on agile positioning in their companies. At broader level, the work done in this workshop will contribute towards developing Agile Positioning System.

  17. Umbilic Lines in Orientational Order

    Directory of Open Access Journals (Sweden)

    Thomas Machon

    2016-03-01

    Full Text Available Three-dimensional orientational order in systems whose ground states possess nonzero gradients typically exhibits linelike structures or defects: λ lines in cholesterics or Skyrmion tubes in ferromagnets, for example. Here, we show that such lines can be identified as a set of natural geometric singularities in a unit vector field, the generalization of the umbilic points of a surface. We characterize these lines in terms of the natural vector bundles that the order defines and show that they give a way to localize and identify Skyrmion distortions in chiral materials—in particular, that they supply a natural representative of the Poincaré dual of the cocycle describing the topology. Their global structure leads to the definition of a self-linking number and helicity integral which relates the linking of umbilic lines to the Hopf invariant of the texture.

  18. Block ground interaction of rockfalls

    Science.gov (United States)

    Volkwein, Axel; Gerber, Werner; Kummer, Peter

    2016-04-01

    During a rockfall the interaction of the falling block with the ground is one of the most important factors that define the evolution of a rockfall trajectory. It steers the rebound, the rotational movement, possibly brake effects, friction losses and damping effects. Therefore, if most reliable rockfall /trajectory simulation software is sought a good understanding of the block ground interaction is necessary. Today's rockfall codes enable the simulation of a fully 3D modelled block within a full 3D surface . However, the details during the contact, i.e. the contact duration, the penetration depth or the dimension of the marks in the ground are usually not part of the simulation. Recent field tests with rocks between 20 and 80 kg have been conducted on a grassy slope in 2014 [1]. A special rockfall sensor [2] within the blocks measured the rotational velocity and the acting accelerations during the tests. External video records and a so-called LocalPositioningSystem deliver information on the travel velocity. With these data not only the flight phases of the trajectories but also the contacts with the ground can be analysed. During the single jumps of a block the flight time, jump length, the velocity, and the rotation are known. During the single impacts their duration and the acting accelerations are visible. Further, the changes of rotational and translational velocity influence the next jump of the block. The change of the rotational velocity over the whole trajectory nicely visualizes the different phases of a rockfall regarding general acceleration and deceleration in respect to the inclination and the topography of the field. References: [1] Volkwein A, Krummenacher B, Gerber W, Lardon J, Gees F, Brügger L, Ott T (2015) Repeated controlled rockfall trajectory testing. [Abstract] Geophys. Res. Abstr. 17: EGU2015-9779. [2] Volkwein A, Klette J (2014) Semi-Automatic Determination of Rockfall Trajectories. Sensors 14: 18187-18210.

  19. Researcher positioning

    DEFF Research Database (Denmark)

    Mørck, Line Lerche; Khawaja, Iram

    2009-01-01

    abstract  This article focuses on the complex and multi-layered process of researcher positioning, specifically in relation to the politically sensitive study of marginalised and ‘othered' groups such as Muslims living in Denmark. We discuss the impact of different ethnic, religious and racial...... political and personal involvement by the researcher, which challenges traditional perspectives on research and researcher positioning. A key point in this regard is the importance of constant awareness of and reflection on the multiple ways in which one's positioning as a researcher influences the research...

  20. Ground State Spin Logic

    CERN Document Server

    Whitfield, J D; Biamonte, J D

    2012-01-01

    Designing and optimizing cost functions and energy landscapes is a problem encountered in many fields of science and engineering. These landscapes and cost functions can be embedded and annealed in experimentally controllable spin Hamiltonians. Using an approach based on group theory and symmetries, we examine the embedding of Boolean logic gates into the ground state subspace of such spin systems. We describe parameterized families of diagonal Hamiltonians and symmetry operations which preserve the ground state subspace encoding the truth tables of Boolean formulas. The ground state embeddings of adder circuits are used to illustrate how gates are combined and simplified using symmetry. Our work is relevant for experimental demonstrations of ground state embeddings found in both classical optimization as well as adiabatic quantum optimization.

  1. Ground Vehicle Robotics Presentation

    Science.gov (United States)

    2012-08-14

    Mr. Jim Parker Associate Director Ground Vehicle Robotics Distribution Statement A. Approved for public release Report Documentation Page...Briefing 3. DATES COVERED 01-07-2012 to 01-08-2012 4. TITLE AND SUBTITLE Ground Vehicle Robotics Presentation 5a. CONTRACT NUMBER 5b. GRANT...ABSTRACT Provide Transition-Ready, Cost-Effective, and Innovative Robotics and Control System Solutions for Manned, Optionally-Manned, and Unmanned

  2. Researcher positioning

    DEFF Research Database (Denmark)

    Mørck, Line Lerche; Khawaja, Iram

    2009-01-01

    abstract  This article focuses on the complex and multi-layered process of researcher positioning, specifically in relation to the politically sensitive study of marginalised and ‘othered' groups such as Muslims living in Denmark. We discuss the impact of different ethnic, religious and racial...... political and personal involvement by the researcher, which challenges traditional perspectives on research and researcher positioning. A key point in this regard is the importance of constant awareness of and reflection on the multiple ways in which one's positioning as a researcher influences the research...... process. Studying the other calls for close reflections on one's own position, theoretically, personally, and politically, taking into account one's complicity in either overcoming or reproducing processes of othering and marginalisation. [i] We use the term (ethnic) minoritised, not as a distinction...

  3. Patches of bare ground as a staple commodity for declining ground-foraging insectivorous farmland birds.

    Science.gov (United States)

    Schaub, Michael; Martinez, Nicolas; Tagmann-Ioset, Aline; Weisshaupt, Nadja; Maurer, Melanie L; Reichlin, Thomas S; Abadi, Fitsum; Zbinden, Niklaus; Jenni, Lukas; Arlettaz, Raphaël

    2010-10-06

    Conceived to combat widescale biodiversity erosion in farmland, agri-environment schemes have largely failed to deliver their promises despite massive financial support. While several common species have shown to react positively to existing measures, rare species have continued to decline in most European countries. Of particular concern is the status of insectivorous farmland birds that forage on the ground. We modelled the foraging habitat preferences of four declining insectivorous bird species (hoopoe, wryneck, woodlark, common redstart) inhabiting fruit tree plantations, orchards and vineyards. All species preferred foraging in habitat mosaics consisting of patches of grass and bare ground, with an optimal, species-specific bare ground coverage of 30-70% at the foraging patch scale. In the study areas, birds thrived in intensively cultivated farmland where such ground vegetation mosaics existed. Not promoted by conventional agri-environment schemes until now, patches of bare ground should be implemented throughout grassland in order to prevent further decline of insectivorous farmland birds.

  4. Energized overhead ground wires - OHGWs the pioneer Brazilian application

    Energy Technology Data Exchange (ETDEWEB)

    D`Ajuz, Ary; Martinez, Manuel L.B.; Araujo, Ana Maria R.; Takai, Mario Noboru; Sganzerla, Flavio [ELETRONORTE, Brasilia, DF (Brazil); O. Junior, Helio P.; Fonseca, Claudio S. [Marte Engenharia (Brazil); Guimaraes, R.P.; Mendes, Eloisa R.

    1994-12-31

    This paper introduces an economical solution for close HV lines small villages and farms load supply. The needed modifications to adapt a planned transmission system to supply loads located along the lines routes are presented. The paper describes the two overhead ground wires scheme planned for implementation in the 230 kV transmission line under construction by ELETRONORTE in Mato Grosso and Rondonia supplying loads each one totaling roughly 8 MW. (author) 4 refs., 4 figs., 2 tabs.

  5. Pc5 Oscillation Analysis by the Satellite and Ground-Based Data

    Institute of Scientific and Technical Information of China (English)

    A. Potapov; T. Polyushkina; T. L. Zhang; H. Zhao; A. Guglielmi; J. Kultima

    2005-01-01

    Large amplitude Pc5 event was observed in the space and on ground on August 3, 2001, about three hours after contact of the strong discontinuity in the solar wind with the magnetosphere according to data from ACE and Wind satellites. The Pc5 amplitude was as high as 15 nT in the tail of magnetosphere and about 5 nT at the ground based stations. In the magnetosphere Pc5 waves were observed by Cluster and Polar satellites, which occupied positions in the morning part of the near tail at the close field lines but were parted by distance of 11.5 Re, mainly along the x-axis of the GSM coordinate system. Both compressional and transverse components of the Pc5 wave activity were observed in the space, with the transverse component having the larger amplitude. Time delay between the Cluster and Polar satellites was about 8 minutes, which could be interpreted as a wave propagation from the geomagnetic tail to the Earth with the 150km/s group velocity.The ground-based Pc5 activity was analysed by using data from the Image magnetometer network. Doubtless demonstrations of a field line resonant structure were found in variations of amplitude and polarization with latitude. Finnish chain of search coil magnetometers observed modulated Pc1 emission simultaneously with the Pc5 wave train. A possibility of non-linear impact of Pc5 wave energy on the plasma and waves in the magnetosphere is discussed.

  6. production lines

    Directory of Open Access Journals (Sweden)

    Jingshan Li

    2000-01-01

    Full Text Available In this work, serial production lines with finished goods buffers operating in the pull regime are considered. The machines are assumed to obey Bernoulli reliability model. The problem of satisfying customers demand is addressed. The level of demand satisfaction is quantified by the due-time performance (DTP, which is defined as the probability to ship to the customer a required number of parts during a fixed time interval. Within this scenario, the definitions of DTP bottlenecks are introduced and a method for their identification is developed.

  7. Distributed operating system for NASA ground stations

    Science.gov (United States)

    Doyle, John F.

    1987-01-01

    NASA ground stations are characterized by ever changing support requirements, so application software is developed and modified on a continuing basis. A distributed operating system was designed to optimize the generation and maintenance of those applications. Unusual features include automatic program generation from detailed design graphs, on-line software modification in the testing phase, and the incorporation of a relational database within a real-time, distributed system.

  8. Distributed operating system for NASA ground stations

    Science.gov (United States)

    Doyle, John F.

    1987-01-01

    NASA ground stations are characterized by ever changing support requirements, so application software is developed and modified on a continuing basis. A distributed operating system was designed to optimize the generation and maintenance of those applications. Unusual features include automatic program generation from detailed design graphs, on-line software modification in the testing phase, and the incorporation of a relational database within a real-time, distributed system.

  9. Ground Enterprise Management System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Emergent Space Technologies Inc. proposes to develop the Ground Enterprise Management System (GEMS) for spacecraft ground systems. GEMS will provide situational...

  10. Positive Aesthetics : claims and problems

    OpenAIRE

    Alcaraz León, María José

    2010-01-01

    In this paper I present an overview of the doctrine known as Positive Aesthetics regarding aesthetic judgements about nature. According to this view, all pristine nature is always beautiful and, generally, although not necessarily, human intervention tends to introduce ugliness in nature. One of the strong practical motivations behind this claim is an attempt to ground our reasons to preserve natural environments in aesthetic reasons. Positive Aesthetics has been defended within contrary appr...

  11. Positional games

    CERN Document Server

    Hefetz, Dan; Stojaković, Miloš; Szabó, Tibor

    2014-01-01

    This text serves as a thorough introduction to the rapidly developing field of positional games. This area constitutes an important branch of combinatorics, whose aim it is to systematically develop an extensive mathematical basis for a variety of two-player perfect information games. These range from such popular games as Tic-Tac-Toe and Hex to purely abstract games played on graphs and hypergraphs. The subject of positional games is strongly related to several other branches of combinatorics such as Ramsey theory, extremal graph and set theory, and the probabilistic method. These notes cover a variety of topics in positional games, including both classical results and recent important developments. They are presented in an accessible way and are accompanied by exercises of varying difficulty, helping the reader to better understand the theory. The text will benefit both researchers and graduate students in combinatorics and adjacent fields.

  12. Researcher Positioning

    DEFF Research Database (Denmark)

    Khawaja, Iram; Mørck, Line Lerche

    2009-01-01

    This article focuses on the complex and multilayered process of researcher positioning,specifically in relation to the politically sensitive study of marginalised and "othered"groups such as Muslims living in Denmark. We discuss the impact of different ethnic,religious, and racial backgrounds...... involvement by the researcher, which challenges traditional perspectives onresearch and researcher positioning. A key point in this regard is the importance ofconstant awareness of and reflection on the multiple ways in which one's positioningas a researcher influences the research process. Studying the other...

  13. Reinventing Grounded Theory: Some Questions about Theory, Ground and Discovery

    Science.gov (United States)

    Thomas, Gary; James, David

    2006-01-01

    Grounded theory's popularity persists after three decades of broad-ranging critique. In this article three problematic notions are discussed--"theory," "ground" and "discovery"--which linger in the continuing use and development of grounded theory procedures. It is argued that far from providing the epistemic security promised by grounded theory,…

  14. Positively Adolescent!

    Science.gov (United States)

    Williamson, Sue

    2000-01-01

    Believes that music teachers should reassess their views toward adolescent behavior in the music classroom by learning to see their behavior in a positive light. Describes teaching strategies that build on four adolescent behaviors: (1) desire for peer acceptance; (2) abundant energy; (3) love of fun; and (4) limited time-managing skills. (CMK)

  15. Ground water in Oklahoma

    Science.gov (United States)

    Leonard, A.R.

    1960-01-01

    One of the first requisites for the intelligent planning of utilization and control of water and for the administration of laws relating to its use is data on the quantity, quality, and mode of occurrence of the available supplies. The collection, evaluation and interpretation, and publication of such data are among the primary functions of the U.S. Geological Survey. Since 1895 the Congress has made appropriations to the Survey for investigation of the water resources of the Nation. In 1929 the Congress adopted the policy of dollar-for-dollar cooperation with the States and local governmental agencies in water-resources investigations of the U.S. Geological Survey. In 1937 a program of ground-water investigations was started in cooperation with the Oklahoma Geological Survey, and in 1949 this program was expanded to include cooperation with the Oklahoma Planning and Resources Board. In 1957 the State Legislature created the Oklahoma Water Resources Board as the principal State water agency and it became the principal local cooperator. The Ground Water Branch of the U.S. Geological Survey collects, analyzes, and evaluates basic information on ground-water resources and prepares interpretive reports based on those data. Cooperative ground-water work was first concentrated in the Panhandle counties. During World War II most work was related to problems of water supply for defense requirements. Since 1945 detailed investigations of ground-water availability have been made in 11 areas, chiefly in the western and central parts of the State. In addition, water levels in more than 300 wells are measured periodically, principally in the western half of the State. In Oklahoma current studies are directed toward determining the source, occurrence, and availability of ground water and toward estimating the quantity of water and rate of replenishment to specific areas and water-bearing formations. Ground water plays an important role in the economy of the State. It is

  16. Fault diagnosis in neutral point indirectly grounded system based on information fusion

    Institute of Scientific and Technical Information of China (English)

    于飞; 鞠丽叶; 刘喜梅; 崔平远; 钟秋海

    2003-01-01

    In neutral point indirectly grounded systems, phase-to-ground fault is putting new demands on fault diagnosis technology. Information fusion is applied to detect the phase-to-ground fault, which integrates several sources of information, including line current, line voltage, zero sequence current and voltage, and quintic harmonic wave component. This method is testified through the simulation of Matlab. Simulation results show that the precision and reliability of the detection has been greatly increased.

  17. Parallel Lines

    Directory of Open Access Journals (Sweden)

    James G. Worner

    2017-05-01

    Full Text Available James Worner is an Australian-based writer and scholar currently pursuing a PhD at the University of Technology Sydney. His research seeks to expose masculinities lost in the shadow of Australia’s Anzac hegemony while exploring new opportunities for contemporary historiography. He is the recipient of the Doctoral Scholarship in Historical Consciousness at the university’s Australian Centre of Public History and will be hosted by the University of Bologna during 2017 on a doctoral research writing scholarship.   ‘Parallel Lines’ is one of a collection of stories, The Shapes of Us, exploring liminal spaces of modern life: class, gender, sexuality, race, religion and education. It looks at lives, like lines, that do not meet but which travel in proximity, simultaneously attracted and repelled. James’ short stories have been published in various journals and anthologies.

  18. On the Interpretation of Gravity Wave Measurements by Ground-Based Lidars

    Directory of Open Access Journals (Sweden)

    Andreas Dörnbrack

    2017-03-01

    Full Text Available This paper asks the simple question: How can we interpret vertical time series of middle atmosphere gravity wave measurements by ground-based temperature lidars? Linear wave theory is used to show that the association of identified phase lines with quasi-monochromatic waves should be considered with great care. The ambient mean wind has a substantial effect on the inclination of the detected phase lines. The lack of knowledge about the wind might lead to a misinterpretation of the vertical propagation direction of the observed gravity waves. In particular, numerical simulations of three archetypal atmospheric mountain wave regimes show a sensitivity of virtual lidar observations on the position relative to the mountain and on the scale of the mountain.

  19. Detection of ground ice using ground penetrating radar method

    Institute of Scientific and Technical Information of China (English)

    Gennady M. Stoyanovich; Viktor V. Pupatenko; Yury A. Sukhobok

    2015-01-01

    The paper presents the results of a ground penetrating radar (GPR) application for the detection of ground ice. We com-bined a reflection traveltime curves analysis with a frequency spectrogram analysis. We found special anomalies at specific traces in the traveltime curves and ground boundaries analysis, and obtained a ground model for subsurface structure which allows the ground ice layer to be identified and delineated.

  20. Collison and Grounding

    DEFF Research Database (Denmark)

    Wang, G.; Ji, C.; Kuhala, P.;

    2006-01-01

    COMMITTEE MANDATE Concern for structural arrangements on ships and floating structures with regard to their integrity and adequacy in the events of collision and grounding, with the view towards risk assessment and management. Consideration shall be given to the frequency of occurrence, the proba......COMMITTEE MANDATE Concern for structural arrangements on ships and floating structures with regard to their integrity and adequacy in the events of collision and grounding, with the view towards risk assessment and management. Consideration shall be given to the frequency of occurrence...

  1. Clinical efficacy of posterior surgery for cervical ossification of posterior longitudinal ligament with K-line positive in extension radiograph%后路手术治疗过伸位K线阳性颈椎后纵韧带骨化症的疗效

    Institute of Scientific and Technical Information of China (English)

    陈德纯; 陈宇; 陈德玉

    2014-01-01

    目的:观察后路减压手术治疗过伸位K线阳性颈椎后纵韧带骨化症(OPLL)的临床疗效。方法回顾性分析2005年2月至2012年1月第二军医大学附属长征医院收治的72例OPLL患者的临床资料,其中27例行椎板成型术、45例行椎板切除减压内固定术。根据OPLL骨化最高点相对于K线的位置,分为K线阳性组(标准侧位片K线阳性,39例)和过伸位K线阳性组(标准侧位片K线阴性但过伸位侧位片K线阳性,33例)。记录术前和术后1年两组患者的日本骨科学会(JOA)评分,计算恢复率。结果术后1年,K线阳性组JOA评分由术前的(11.3±2.9)分提高到(14.2±3.0)分(P<0.05),过伸位K线阳性组JOA评分由术前的(10.5±1.8)分提高到(13.3±2.7)分(P<0.05),但术前、术后JOA评分组间比较,差异无统计学意义(P>0.05);K线阳性组和过伸位K线阳性组恢复率分别为(51±22)%和(44±23)%,两组比较,差异无统计学意义(P>0.05)。结论对过伸位K线阳性颈椎OPLL患者施行后路手术可以获得与K线阳性患者相当的临床疗效。%Objective To evaluate the clinical effects of posterior surgery for cervical ossification of posterior longitudinal ligament (OPLL) with K-line positive in extension lateral X-ray film. Methods Seventy-two patients with cervical OPLL underwent posterior laminoplasty (27 patients) or laminectomy (45 cases) in Changzheng Hospital of the Second Military Medical University from February 2005 to January 2012, and their clinical data were reviewed retrospectively. According to the position relation of K-line and the range of OPLL, patients were classified into 2 groups, K-line positive group (OPLL not beyond K-line, 39 cases) and group of K-line positive in extension radiograph (OPLL beyond K-line in normal lateral X-ray film but not beyond K-line in extension lateral film, 33 cases). Japanese Orthopaedic Association

  2. Induction of MTG8-specific cytotoxic T-cell lines: MTG8 is probably a tumour antigen that is recognized by cytotoxic T cells in AML1-MTG8-fused gene-positive acute myelogenous leukaemia.

    Science.gov (United States)

    Maeda, M; Otsuka, T; Kimura, N; Kozu, T; Fukuyama, T; Uchida, N; Sugio, Y; Itoh, Y; Iino, T; Inaba, S; Niho, Y

    2000-11-01

    Several reports have demonstrated the persistent detection of AML1-MTG8 fusion products, representing minimal residual disease (MRD), in patients with t(8;21) acute myelogenous leukaemia (AML) who are in long-term remission. It is probable that immune-mediated mechanisms that are able to suppress the expansion of MRD may result in the continuance of remission. It was previously shown that some t(8;21) AML patients had high anti-MTG8 antibody titres. MTG8 expression in normal adult tissues is limited to the brain or heart in which human leucocyte antigen (HLA) class I cell-surface antigens are either not or are only faintly detectable. We hypothesized that the overexpression of the MTG8 gene in t(8;21) AML cells could act as a possible tumour antigen, which might be able to induce the immune-mediated suppression of the expansion of MRD. We were able to induce HLA-A0201-restricted cytotoxic T-lymphocyte (CTL) lines against an MTG8 peptide (MTG8b amino acids 182-191) using monocyte-derived dendritic cells from a healthy donor. T-cell receptor (TCR)Valpha17, TCRVbeta14 and 15, and TCRJbeta2.1 and 2.3 are predominantly used in these CTL lines. Our data, which suggest that the MTG8 protein could be one of the tumour antigens recognized by CTLs, may be helpful in further investigations of TCR analysis in t(8;21) AML patients with HLA-A0201 who are in long-term remission.

  3. The historical power lines. The climate political positions and strategies towards emission intensive industry in five Norwegian industrial counties; Historiens kraftlinjer. Klimapolitiske posisjoner og strategier overfor utslippsintensiv industri i fem norske industrikommuner

    Energy Technology Data Exchange (ETDEWEB)

    Kasa, Sjur

    2003-07-01

    What is the position of the industrial communities in Norway in the political process behind the regulation of greenhouse gases from industrial sources and what strategies do they use to achieve their objectives. Interviews conducted with local governmental leaders in five industrial communities in Norway revealed that concerns about industrial closure, both within their own and neighbouring municipalities and well established industrial traditions had a clear influence on their climate policy perspectives regardless of their party affiliation. Strategies employed by industrial communities to promote their interests and communicate their positions to central authorities include not only traditional lobbying at the state level but also co-operation through horizontal networks of both private and public actors at the inter-municipal and inter-regional level. These horizontal networks are particularly important in connection with the proposed construction of gas fired power plants and increasing the industrial application of natural gas. (Author)

  4. Coding Issues in Grounded Theory

    Science.gov (United States)

    Moghaddam, Alireza

    2006-01-01

    This paper discusses grounded theory as one of the qualitative research designs. It describes how grounded theory generates from data. Three phases of grounded theory--open coding, axial coding, and selective coding--are discussed, along with some of the issues which are the source of debate among grounded theorists, especially between its…

  5. Coding Issues in Grounded Theory

    Science.gov (United States)

    Moghaddam, Alireza

    2006-01-01

    This paper discusses grounded theory as one of the qualitative research designs. It describes how grounded theory generates from data. Three phases of grounded theory--open coding, axial coding, and selective coding--are discussed, along with some of the issues which are the source of debate among grounded theorists, especially between its…

  6. Predicting above-ground density and distribution of small mammal prey species at large spatial scales.

    Science.gov (United States)

    Olson, Lucretia E; Squires, John R; Oakleaf, Robert J; Wallace, Zachary P; Kennedy, Patricia L

    2017-01-01

    Grassland and shrub-steppe ecosystems are increasingly threatened by anthropogenic activities. Loss of native habitats may negatively impact important small mammal prey species. Little information, however, is available on the impact of habitat variability on density of small mammal prey species at broad spatial scales. We examined the relationship between small mammal density and remotely-sensed environmental covariates in shrub-steppe and grassland ecosystems in Wyoming, USA. We sampled four sciurid and leporid species groups using line transect methods, and used hierarchical distance-sampling to model density in response to variation in vegetation, climate, topographic, and anthropogenic variables, while accounting for variation in detection probability. We created spatial predictions of each species' density and distribution. Sciurid and leporid species exhibited mixed responses to vegetation, such that changes to native habitat will likely affect prey species differently. Density of white-tailed prairie dogs (Cynomys leucurus), Wyoming ground squirrels (Urocitellus elegans), and leporids correlated negatively with proportion of shrub or sagebrush cover and positively with herbaceous cover or bare ground, whereas least chipmunks showed a positive correlation with shrub cover and a negative correlation with herbaceous cover. Spatial predictions from our models provide a landscape-scale metric of above-ground prey density, which will facilitate the development of conservation plans for these taxa and their predators at spatial scales relevant to management.

  7. 高效点胶机器人磁路封装线塞规加载与卸载工位的研发%Research and Development of the Position Used to Load and Unload Plug Located in Magnetic Circuit Packaging Line with High Efficient Dispensing Robots

    Institute of Scientific and Technical Information of China (English)

    章磊

    2012-01-01

    研发了点胶机器人磁路封装线上塞规加载与卸载工位,该工位的上下料、搬运、精确定位与装配流程采取了气动机械手臂控制方案.经生产实践证明,在磁路封装线上采用机械手臂系统使各个工位既独立受控又相互牵制,组合形成了一个整体,方便对每个工位进行相应的工业参数设置.最后对塞规约束力的仿真实验证实了该工位系统设计合理,能够满足生产自动化的需求.%The research and development of the position in which the dispensing robots are used to load and unload the plug in the magnetic circuit packaging line. The proposal of the pneumatic robot arm control is used for the positions' loading and unloading, transportation, precise positioning and assembling processes. It can be proved by the production practice that the adoption of the robot arm system in the magnetic circuit packaging line can not only control each position independently but also constitute a whole by against each other, which makes it convenient to set the corresponding industrial parameter for each position. The simula- tion experiment of plug binding finally verify that this position system is designed reasonably and can satisfy the demand of production automation.

  8. Mapping your competitive position.

    Science.gov (United States)

    D'Aveni, Richard A

    2007-11-01

    A price-benefit positioning map helps you see, through your customers' eyes, how your product compares with all its competitors in a market. You can draw such a map quickly and objectively, without having to resort to costly, time-consuming consumer surveys or subjective estimates of the excellence of your product and the shortcomings of all the others. Creating a positioning map involves three steps: First, define your market to include everything your customers might consider to be your product's competitors or substitutes. Second, track the price your customers actually pay (wholesale or retail? bundled or unbundled?) and identify what your customers see as your offering's primary benefit. This is done through regression analysis, determining which of the product's attributes (as described objectively by rating services, government agencies, R&D departments, and the like) explains most of the variance in its price. Third, draw the map by plotting on a graph the position of every product in the market you've selected according to its price and its level of primary benefit, and draw a line that runs through the middle of the points. What you get is a picture of the competitive landscape of your market, where all the products above the line command a price premium owing to some secondary benefit customers value, and all those below the line are positioned to earn market share through lower prices and reduced secondary benefits. Using examples as varied as Harley-Davidson motorcycles, Motorola cell phones, and the New York restaurant market, Tuck professor D'Aveni demonstrates some of the many ways the maps can be used: to locate unoccupied or less-crowded spaces in highly competitive markets, for instance, or to identify opportunities created through changes in the relationship between the primary benefit and prices. The maps even allow companies to anticipate--and counter-- rivals' strategies. R eprint RO711G

  9. Mechanics of Ship Grounding

    DEFF Research Database (Denmark)

    Pedersen, Preben Terndrup

    1996-01-01

    In these notes first a simplified mathematical model is presented for analysis of ship hull loading due to grounding on relatively hard and plane sand, clay or rock sea bottoms. In a second section a more rational calculation model is described for the sea bed soil reaction forces on the sea bottom...

  10. Grounding Anger Management

    Directory of Open Access Journals (Sweden)

    Odis E. Simmons, PhD

    2017-06-01

    Full Text Available One of the things that drew me to grounded theory from the beginning was Glaser and Strauss’ assertion in The Discovery of Grounded Theory that it was useful as a “theoretical foothold” for practical applications (p. 268. From this, when I was a Ph.D student studying under Glaser and Strauss in the early 1970s, I devised a GT based approach to action I later came to call “grounded action.” In this short paper I’ll present a very brief sketch of an anger management program I developed in 1992, using grounded action. I began my research by attending a two-day anger management training workshop designed for training professionals in the most commonly used anger management model. Like other intervention programs I had seen, this model took a psychologizing and pathologizing approach to the issue. Following this, I sat through the full course of an anger management program that used this model, observing the reactions of the participants and the approach of the facilitator. Following each session I conducted open-ended interviews with most of the participants, either individually or in groups of two or three. I had also done previous research in counseling and social work contexts that turned out to be very relevant to an anger management program design.

  11. Grounding in Instant Messaging

    Science.gov (United States)

    Fox Tree, Jean E.; Mayer, Sarah A.; Betts, Teresa E.

    2011-01-01

    In two experiments, we investigated predictions of the "collaborative theory of language use" (Clark, 1996) as applied to instant messaging (IM). This theory describes how the presence and absence of different grounding constraints causes people to interact differently across different communicative media (Clark & Brennan, 1991). In Study 1, we…

  12. Informed Grounded Theory

    Science.gov (United States)

    Thornberg, Robert

    2012-01-01

    There is a widespread idea that in grounded theory (GT) research, the researcher has to delay the literature review until the end of the analysis to avoid contamination--a dictum that might turn educational researchers away from GT. Nevertheless, in this article the author (a) problematizes the dictum of delaying a literature review in classic…

  13. TARDEC Ground Vehicle Robotics

    Science.gov (United States)

    2013-05-30

    UNCLASSIFIED UNCLASSIFIED 10 Optionally Manned Vehicles OMV can be driven by a soldier; OMV can drive a soldier; OMV can be remotely operated; OMV can be...all missions for OMV (i.e. shared driving) (i.e. remotely operated) 2 m od al iti es Mission Payloads UNCLASSIFIED UNCLASSIFIED 11 Ground

  14. Accurate internuclear potential energy functions for the ground electronic states of NeH+ and ArH+

    Science.gov (United States)

    Coxon, John A.; Hajigeorgiou, Photos G.

    2016-12-01

    All pure rotational and vibrational-rotational spectroscopic line positions available on the ground X1Σ+ electronic states of the rare gas hydride cations NeH+ and ArH+ have been employed in weighted least-squares direct fits to the potential energy functions, together with auxiliary functions describing breakdown of the Born-Oppenheimer approximation. All radial functions are represented by compact analytical models, and the spectroscopic line positions are reproduced to within the associated experimental uncertainties by the quantum-mechanical eigenvalues of the derived Hamiltonians. The potential energy functions are constrained to approach the theoretical radial behavior at long-range. Accurate vibrational term values and rotational and centrifugal distortion constants are provided for all stable isotopologues of NeH+ and ArH+ included in the least-squares fits.

  15. The study on the measurement of related lines and the positioning of human foramina infraorbitale%眶下孔相关径线测量及定位研究

    Institute of Scientific and Technical Information of China (English)

    孙雪梅; 徐剑; 孙波; 赵晓晖; 王振江; 沈维高

    2015-01-01

    目的:测量完整人颅骨的眶下孔的相关径线,为临床应用提供数据。方法用游标卡尺测量60例(120侧)成人眶下孔内径的长径和短径,并观察孔的形状,观察副孔的数量。测量眶下孔到眶下缘的距离,切此线与面部前正中线平行。测量眶下孔到梨状孔外缘的距离,切此线与面部前正中线垂直。结果①眶下孔为圆孔(10%)和椭圆形孔(90%);②左右两侧眶下孔副孔总的出现率为2.5%。③眶下孔的长径为(4.24±0.91)mm(2.48~7.59 mm)。④眶下孔的短径为(2.55±0.48)mm(1.37~3.63 mm)。⑤眶下孔到眶下缘的距离为(8.54±1.60)mm(5.16~13.63 mm)。⑥眶下孔到梨状孔外缘的距离为(16.55±2.01)mm(11.73~23.17 mm)。结论完善人颅骨眶下孔的形态学资料,为临床开展眶下孔的应用研究提供数据。%Objective To study the relevant radial lines, the size, and the location of foramina infraorbitale, providing scientific and reasonable basic materials for clinic application. Methods The long and short diameter of infraorbital foramina in 60 cadavers (120 sides) were measured by ordinary vernier caliper. The shape of the hole, the number of accessory infraorbital holes were also record; the distance between the infraorbital foramen and the inferior margin of the eye socket, the distance from the line between the infraorbital foramen to the anterior midline of the face were measured. The distance between the infraorbital foramen and the piriform foramen, and the distance from the line between the infraorbital foramen the piriform foramen to the anterior midline of the face were measured. Results The probability of foramina infraorbitale being elliptical in shape accounted for 90%, circular for 10%. The total occurrence rate of accessory foramen was 2.5%. The long diameter of the foramina infraorbitale ranged from 2.48 mm to7.59 mm, with an average of (4.24 ± 0.91) mm;The short diameter

  16. Positionality at the Center

    Directory of Open Access Journals (Sweden)

    Catherine Vanner

    2015-11-01

    Full Text Available As a Western feminist supporting and researching gender equality in education in postcolonial contexts, I often wonder: Am I doing more harm than good? The privilege of my social location means that my efforts to support education in postcolonial contexts risk being patronizing, insulting, threatening, imperialist, and recolonizing. Yet neglecting and ignoring postcolonial contexts similarly reflects and reproduces a privileged position. I provide a tentative framework designed to address positionality, power, and privilege while creating an ethical research process for working in a postcolonial context. Beginning with an identification of positionality, the objectives of research, and guiding theoretical frameworks to situate the research in relation to the participants and context, I proceed to establish a methodology designed to minimize the negative effects of power and maximize participants’ empowerment. I position myself as a bricoleur, layering feminist standpoint theory and postcolonial theory, and propose the collaborative data collection and analysis techniques, with particular attention to ethical and cultural sensitivity, using a social constructivist approach to grounded theory. This article highlights the need for Western researchers to reflect upon the power dynamics of their research in postcolonial contexts and develop a strategy for conducting empowering research that prevents the misrepresentation and exploitation of participants. Observations from my doctoral thesis data collection provide examples of how these concepts were operationalized in practice as well as reflections on the disconnect between theorizing and conducting ethical research in postcolonial contexts.

  17. Investigation of full and partial ground effects on a flapping foil hovering above a finite-sized platform

    Science.gov (United States)

    Wang, Lu; Yeung, Ronald W.

    2016-07-01

    The full and partial ground effects on the lift generation of a flapping airfoil in normal hovering mode are investigated numerically using the discrete vortex method in two dimensions. To achieve full ground effect, the airfoil of chord c is made to hover above the center of a finite-sized platform of length 10c. We have observed the force-enhancement, force-reduction, and force-recovery regimes at low, medium, and high ground clearances in line with the existing literature. This paper puts special focus on partial ground effect when the airfoil is hovering near the edge of the platform. Lift-modifying mechanisms not previously observed under full ground effect have been discovered. When stroke reversal occurs near the edge of the platform, a relatively stationary strong vortex may form above the platform edge. This strong vortex can either increase or decrease the instantaneous lift force on the airfoil depending on the position of the airfoil relative to the platform edge. Also, the platform edge may lead to the formation of an additional vortex pair which increases the instantaneous lift force as the airfoil sweeps past the edge under suitable conditions. Lastly, the platform edge can lead to the formation of a reverse von Kármán vortex street that extends well below the stroke plane under suitable geometric arrangements.

  18. Palbociclib as a first-line treatment in oestrogen receptor-positive, HER2-negative, advanced breast cancer not cost-effective with current pricing: a health economic analysis of the Swiss Group for Clinical Cancer Research (SAKK).

    Science.gov (United States)

    Matter-Walstra, K; Ruhstaller, T; Klingbiel, D; Schwenkglenks, M; Dedes, K J

    2016-07-01

    Endocrine therapy continues to be the optimal systemic treatment for metastatic ER(+)HER2(-) breast cancer. The CDK4/6 inhibitor palbociclib combined with letrozole has recently been shown to significantly improve progression-free survival. Here we examined the cost-effectiveness of this regimen for the Swiss healthcare system. A Markov cohort simulation based on the PALOMA-1 trial (Finn et al. in Lancet Oncol 16:25-35, 2015) was used as the clinical course. Input parameters were based on summary trial data. Costs were assessed from the Swiss healthcare system perspective. Adding palbociclib to letrozole (PALLET) compared to letrozole monotherapy was estimated to cost an additional CHF342,440 and gain 1.14 quality-adjusted life years, resulting in an incremental cost-effectiveness ratio (ICER) of CHF301,227/QALY gained. In univariate sensitivity analyses, no tested variation in key parameters resulted in an ICER below a willingness-to-pay threshold of CHF100,000/QALY. PALLET had a 0 % probability of being cost-effective in probabilistic sensitivity analyses. Lowering PALLET's price by 75 % resulted in an ICER of CHF73,995/QALY and a 73 % probability of being cost-effective. At current prices, PALLET would cost the Swiss healthcare system an additional CHF155 million/year. Palbociclib plus letrozole cannot be considered cost-effective for the first-line treatment of patients with metastatic breast cancer in the Swiss healthcare system.

  19. Comparison of algorithms for finding the air-ground interface in ground penetrating radar signals

    Science.gov (United States)

    Wood, Joshua; Bolton, Jeremy; Casella, George; Collins, Leslie; Gader, Paul; Glenn, Taylor; Ho, Jeffery; Lee, Wen; Mueller, Richard; Smock, Brandon; Torrione, Peter; Watford, Ken; Wilson, Joseph

    2011-06-01

    In using GPR images for landmine detection it is often useful to identify the air-ground interface in the GPR signal for alignment purposes. A number of algorithms have been proposed to solve the air-ground interface detection problem, including some which use only A-scan data, and others which track the ground in B-scans or C-scans. Here we develop a framework for comparing these algorithms relative to one another and we examine the results. The evaluations are performed on data that have been categorized in terms of features that make the air-ground interface difficult to find or track. The data also have associated human selected ground locations, from multiple evaluators, that can be used for determining correctness. A distribution is placed over each of the human selected ground locations, with the sum of these distributions at the algorithm selected location used as a measure of its correctness. Algorithms are also evaluated in terms of how they affect the false alarm and true positive rates of mine detection algorithms that use ground aligned data.

  20. Infrasonic induced ground motions

    Science.gov (United States)

    Lin, Ting-Li

    On January 28, 2004, the CERI seismic network recorded seismic signals generated by an unknown source. Our conclusion is that the acoustic waves were initiated by an explosive source near the ground surface. The meteorological temperature and effective sound speed profiles suggested existence of an efficient near-surface waveguide that allowed the acoustic disturbance to propagate to large distances. An explosion occurring in an area of forest and farms would have limited the number of eyewitnesses. Resolution of the source might be possible by experiment or by detailed analysis of the ground motion data. A seismo-acoustic array was built to investigate thunder-induced ground motions. Two thunder events with similar N-wave waveforms but different horizontal slownesses are chosen to evaluate the credibility of using thunder as a seismic source. These impulsive acoustic waves excited P and S reverberations in the near surface that depend on both the incident wave horizontal slowness and the velocity structure in the upper 30 meters. Nineteen thunder events were chosen to further investigate the seismo-acoustic coupling. The consistent incident slowness differences between acoustic pressure and ground motions suggest that ground reverberations were first initiated somewhat away from the array. Acoustic and seismic signals were used to generate the time-domain transfer function through the deconvolution technique. Possible non-linear interaction for acoustic propagation into the soil at the surface was observed. The reverse radial initial motions suggest a low Poisson's ratio for the near-surface layer. The acoustic-to-seismic transfer functions show a consistent reverberation series of the Rayleigh wave type, which has a systematic dispersion relation to incident slownesses inferred from the seismic ground velocity. Air-coupled Rayleigh wave dispersion was used to quantitatively constrain the near-surface site structure with constraints afforded by near-surface body

  1. Decentralized Ground Staff Scheduling

    DEFF Research Database (Denmark)

    Sørensen, M. D.; Clausen, Jens

    2002-01-01

    Typically, ground staff scheduling is centrally planned for each terminal in an airport. The advantage of this is that the staff is efficiently utilized, but a disadvantage is that staff spends considerable time walking between stands. In this paper a decentralized approach for ground staff...... scheduling is investigated. The airport terminal is divided into zones, where each zone consists of a set of stands geographically next to each other. Staff is assigned to work in only one zone and the staff scheduling is planned decentralized for each zone. The advantage of this approach is that the staff...... work in a smaller area of the terminal and thus spends less time walking between stands. When planning decentralized the allocation of stands to flights influences the staff scheduling since the workload in a zone depends on which flights are allocated to stands in the zone. Hence solving the problem...

  2. Ibis ground calibration

    Energy Technology Data Exchange (ETDEWEB)

    Bird, A.J.; Barlow, E.J.; Tikkanen, T. [Southampton Univ., School of Physics and Astronomy (United Kingdom); Bazzano, A.; Del Santo, M.; Ubertini, P. [Istituto di Astrofisica Spaziale e Fisica Cosmica - IASF/CNR, Roma (Italy); Blondel, C.; Laurent, P.; Lebrun, F. [CEA Saclay - Sap, 91 - Gif sur Yvette (France); Di Cocco, G.; Malaguti, E. [Istituto di Astrofisica Spaziale e Fisica-Bologna - IASF/CNR (Italy); Gabriele, M.; La Rosa, G.; Segreto, A. [Istituto di Astrofisica Spaziale e Fisica- IASF/CNR, Palermo (Italy); Quadrini, E. [Istituto di Astrofisica Spaziale e Fisica-Cosmica, EASF/CNR, Milano (Italy); Volkmer, R. [Institut fur Astronomie und Astrophysik, Tubingen (Germany)

    2003-11-01

    We present an overview of results obtained from IBIS ground calibrations. The spectral and spatial characteristics of the detector planes and surrounding passive materials have been determined through a series of calibration campaigns. Measurements of pixel gain, energy resolution, detection uniformity, efficiency and imaging capability are presented. The key results obtained from the ground calibration have been: - optimization of the instrument tunable parameters, - determination of energy linearity for all detection modes, - determination of energy resolution as a function of energy through the range 20 keV - 3 MeV, - demonstration of imaging capability in each mode, - measurement of intrinsic detector non-uniformity and understanding of the effects of passive materials surrounding the detector plane, and - discovery (and closure) of various leakage paths through the passive shielding system.

  3. Mechanics of Ship Grounding

    DEFF Research Database (Denmark)

    Pedersen, Preben Terndrup

    1996-01-01

    In these notes first a simplified mathematical model is presented for analysis of ship hull loading due to grounding on relatively hard and plane sand, clay or rock sea bottoms. In a second section a more rational calculation model is described for the sea bed soil reaction forces on the sea bottom....... Finally, overall hull failure is considered first applying a quasistatic analysis model and thereafter a full dynamic model....

  4. Outdoor ground impedance models.

    Science.gov (United States)

    Attenborough, Keith; Bashir, Imran; Taherzadeh, Shahram

    2011-05-01

    Many models for the acoustical properties of rigid-porous media require knowledge of parameter values that are not available for outdoor ground surfaces. The relationship used between tortuosity and porosity for stacked spheres results in five characteristic impedance models that require not more than two adjustable parameters. These models and hard-backed-layer versions are considered further through numerical fitting of 42 short range level difference spectra measured over various ground surfaces. For all but eight sites, slit-pore, phenomenological and variable porosity models yield lower fitting errors than those given by the widely used one-parameter semi-empirical model. Data for 12 of 26 grassland sites and for three beech wood sites are fitted better by hard-backed-layer models. Parameter values obtained by fitting slit-pore and phenomenological models to data for relatively low flow resistivity grounds, such as forest floors, porous asphalt, and gravel, are consistent with values that have been obtained non-acoustically. Three impedance models yield reasonable fits to a narrow band excess attenuation spectrum measured at short range over railway ballast but, if extended reaction is taken into account, the hard-backed-layer version of the slit-pore model gives the most reasonable parameter values.

  5. The ATLAS SCT grounding and shielding concept and implementation

    CERN Document Server

    Bates, RL; Bernabeu, J; Bizzell, J; Bohm, J; Brenner, R; Bruckman de Renstrom, P A; Catinaccio, A; Cindro, V; Ciocio, A; Civera, J V; Chouridou, S; Dervan, P; Dick, B; Dolezal, Z; Eklund, L; Feld, L; Ferrere, D; Gadomski, S; Gonzalez, F; Gornicki, E; Greenhall, A; Grillo, A A; Grosse-Knetter, J; Gruwe, M; Haywood, S; Hessey, N P; Ikegami, Y; Jones, T J; Kaplon, J; Kodys, P; Kohriki, T; Kondo, T; Koperny, S; Lacasta, C; Lozano Bahilo, J; Malecki, P; Martinez-McKinney, F; McMahon, S J; McPherson, A; Mikulec, B; Mikus, M; Moorhead, G F; Morrissey, M C; Nagai, K; Nichols, A; O'Shea, V; Pater, J R; Peeters, S J M; Pernegger, H; Perrin, E; Phillips, P W; Pieron, J P; Roe, S; Sanchez, J; Spencer, E; Stastny, J; Tarrant, J; Terada, S; Tyndel, M; Unno, Y; Wallny, R; Weber, M; Weidberg, A R; Wells, P S; Werneke, P; Wilmut, I

    2012-01-01

    This paper describes the design and implementation of the grounding and shielding system for the ATLAS SemiConductor Tracker (SCT). The mitigation of electromagnetic interference and noise pickup through power lines is the critical design goal as they have the potential to jeopardize the electrical performance. We accomplish this by adhering to the ATLAS grounding rules, by avoiding ground loops and isolating the different subdetectors. Noise sources are identified and design rules to protect the SCT against them are described. A rigorous implementation of the design was crucial to achieve the required performance. This paper highlights the location, connection and assembly of the different components that affect the grounding and shielding system: cables, filters, cooling pipes, shielding enclosure, power supplies and others. Special care is taken with the electrical properties of materials and joints. The monitoring of the grounding system during the installation period is also discussed. Finally, after con...

  6. Getting around Antarctica: new high-resolution mappings of the grounded and freely-floating boundaries of the Antarctic ice sheet created for the International Polar Year

    Directory of Open Access Journals (Sweden)

    R. Bindschadler

    2011-07-01

    Full Text Available Two ice-dynamic transitions of the Antarctic ice sheet – the boundary of grounded ice features and the freely-floating boundary – are mapped at 15-m resolution by participants of the International Polar Year project ASAID using customized software combining Landsat-7 imagery and ICESat/GLAS laser altimetry. The grounded ice boundary is 53 610 km long; 74 % abuts to floating ice shelves or outlet glaciers, 19 % is adjacent to open or sea-ice covered ocean, and 7 % of the boundary ice terminates on land. The freely-floating boundary, called here the hydrostatic line, is the most landward position on ice shelves that expresses the full amplitude of oscillating ocean tides. It extends 27 521 km and is discontinuous. Positional (one-sigma accuracies of the grounded ice boundary vary an order of magnitude ranging from ±52 m for the land and open-ocean terminating segments to ±502 m for the outlet glaciers. The hydrostatic line is less well positioned with errors over 2 km. Elevations along each line are selected from 6 candidate digital elevation models based on their agreement with ICESat elevation values and surface shape inferred from the Landsat imagery. Elevations along the hydrostatic line are converted to ice thicknesses by applying a firn-correction factor and a flotation criterion. BEDMAP-compiled data and other airborne data are compared to the ASAID elevations and ice thicknesses to arrive at quantitative (one-sigma uncertainties of surface elevations of ±3.6, ±9.6, ±11.4, ±30 and ±100 m for five ASAID-assigned confidence levels. Over one-half of the surface elevations along the grounded ice boundary and over one-third of the hydrostatic line elevations are ranked in the highest two confidence categories. A comparison between ASAID-calculated ice shelf thicknesses and BEDMAP-compiled data indicate a thin-ice bias of 41.2 ± 71.3 m for the ASAID ice thicknesses. The relationship between the seaward offset of the hydrostatic line

  7. Getting around Antarctica: New High-Resolution Mappings of the Grounded and Freely-Floating Boundaries of the Antarctic Ice Sheet Created for the International Polar Year

    Science.gov (United States)

    Bindschadler, R.; Choi, H.; Wichlacz, A.; Bingham, R.; Bohlander, J.; Brunt, K.; Corr, H.; Drews, R.; Fricker, H.; Hall, M.; Hindmarsh, R.; Kohler, J.; Padman, L.; Rack, W.; Rotschkly, G.; Urbini, S.; Vornberger, P.; Young, N.

    2011-01-01

    Two ice-dynamic transitions of the Antarctic ice sheet - the boundary of grounded ice features and the freely-floating boundary - are mapped at 15-m resolution by participants of the International Polar Year project ASAID using customized software combining Landsat-7 imagery and ICESat/GLAS laser altimetry. The grounded ice boundary is 53 610 km long; 74% abuts to floating ice shelves or outlet glaciers, 19% is adjacent to open or sea-ice covered ocean, and 7% of the boundary ice terminates on land. The freely-floating boundary, called here the hydrostatic line, is the most landward position on ice shelves that expresses the full amplitude of oscillating ocean tides. It extends 27 521 km and is discontinuous. Positional (one-sigma) accuracies of the grounded ice boundary vary an order of magnitude ranging from +/- 52m for the land and open-ocean terminating segments to +/- 502m for the outlet glaciers. The hydrostatic line is less well positioned with errors over 2 km. Elevations along each line are selected from 6 candidate digital elevation models based on their agreement with ICESat elevation values and surface shape inferred from the Landsat imagery. Elevations along the hydrostatic line are converted to ice thicknesses by applying a firn-correction factor and a flotation criterion. BEDMAP-compiled data and other airborne data are compared to the ASAID elevations and ice thicknesses to arrive at quantitative (one-sigma) uncertainties of surface elevations of +/-3.6, +/-9.6, +/-11.4, +/-30 and +/-100m for five ASAID-assigned confidence levels. Over one-half of the surface elevations along the grounded ice boundary and over one-third of the hydrostatic line elevations are ranked in the highest two confidence categories. A comparison between ASAID-calculated ice shelf thicknesses and BEDMAP-compiled data indicate a thin-ice bias of 41.2+/-71.3m for the ASAID ice thicknesses. The relationship between the seaward offset of the hydrostatic line from the grounded ice

  8. Formation of Zr I and II lines under non-LTE conditions of stellar atmospheres

    CERN Document Server

    Velichko, A; Nilsson, H

    2011-01-01

    The non-local thermodynaic equilibrium (non-LTE) line formation for the two ions of zirconium is considered through a range of spectral types when the Zr abundance varies from the solar value down to [Zr/H] = -3. The model atom was built using 148 energy levels of Zr I, 772 levels of Zr II, and the ground state of Zr III. It was shown that the main non-LTE mechnism for the minority species Zr I is ultraviolet overionization. Non-LTE leads to systematically depleted total absorption in the Zr I lines and positive abundance corrections, reaching to 0.33 dex for the solar metallicity models. The excited levels of Zr II are overpopulated relative to their thermodynamic equilibrium populations in the line formation layers due to radiative pumping from the low-excitation levels. As a result, the line source function exceeds the Planck function leading to weakening the Zr II lines and positive non-LTE abundance corrections. Such corrections grow towards lower metallicity and lower surface gravity and reach to 0.34 d...

  9. Pre-Service Teachers Constructing Positive Mathematical Identities: Positing a Grounded Theory Approach

    Science.gov (United States)

    Wilson, Sue

    2010-01-01

    Mathematics anxiety in pre-service primary teachers is an important issue in teacher education. This leads to the question of how pre-service primary teachers with mathematics anxiety perceive their mathematical identities. The paper explores the potential to develop a research-based model to identify the process whereby pre-service primary…

  10. AA, sandwich line with magnetic horn

    CERN Document Server

    1980-01-01

    Continuation from 8010293: Finally, the sandwich line with the horn is placed on the ground, for the horn to be inspected and, if needed, exchanged for a new one. The whole procedure was trained with several members of the AA team, for quick and safe handling, and to share the radiation dose amongst them.

  11. The clinical value of CT guidance Hook-wire positioning thoracoscopic surgery for ground-glass opacity lung nodules%术前CT引导下Hook-wire定位胸腔镜切除肺毛玻璃样结节临床研究

    Institute of Scientific and Technical Information of China (English)

    邓俊; 仲宁; 陈文

    2016-01-01

    目的:探讨CT引导下Hook-wire术前定位肺磨玻璃样结节(GGO)在胸腔镜切除术中的应用。方法:25例肺GGO患者均术前行Hook-wire定位,行胸腔镜肺楔形切除术。根据术中冰冻病理结果决定下一步治疗方式。结果:肺GGO直径为(11.48±3.50)mm,距离壁层胸膜(16.52±5.98)mm。CT引导肺GGO Hook-wire定位均成功,定位时间(15.04±3.38)min,出现微量气胸5例(占20%),均不需放置引流管,1例出现少许肺实质出血(占4.00%),无一例出现定位针脱落,实施胸腔镜肺楔形切除100%,其中12例单纯行胸腔镜肺楔形切除手术时间为(21.67±3.94)min,13例为浸润性腺癌,行胸腔镜肺叶或是肺段切除及淋巴结清扫术,手术时间为(58.84±12.01)min。结论:术前CT引导下Hook-wire定位是一种安全可靠且容易掌握的临床技术,降低了手术时间,并发症少,值得临床推广应用。%Objective: To evaluate the clinical application of guidance Hook-wire positioning for ground-glass opacity before video-assisted thoracoscopic resection.Methods: Preoperative location of 25 patients with ground-glass opacity lung nodules was performed using CT-guided Hook-wire technique. Video assisted tho-racic surgery (VATS) pulmonary wedge resection was adopted. According to the result of intraoperative frozen pathology, the next mode of operation was adopted.Results: GGO diameter (11.48±3.50) mm, diatance from the parietal pleura (16.52±5.98) mm. Twenty ifve patients were successfully located. The mean procedure time for preoperative CT-guided Hook-wire location was (15.04±3.38) min. 5 patients had micro pneumothroax after positioning. The chest tube drainage was not required. One patient had minimal needle tract parenchymal hemor-rhages. No one occured migration and fall out of the hookwire. VATS wedge resection surgery successful rate was 100%. Twelve cases of pure thoracoscopy pulmonary wedge

  12. 30 CFR 77.704-1 - Work on high-voltage lines.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Work on high-voltage lines. 77.704-1 Section 77... MINES Grounding § 77.704-1 Work on high-voltage lines. (a) No high-voltage line shall be regarded as... provided in § 77.103) that such high-voltage line has been deenergized and grounded. Such qualified...

  13. 选择性电极型晶硅太阳能电池金属栅线印刷位置精度的检测方法%Detection method of printing position accuracy of selective electrode type amorphous silicon solar battery metal gate line

    Institute of Scientific and Technical Information of China (English)

    段湘宁; 周兵; 沈欣; 于国丰

    2013-01-01

    本文提出一种金属栅线印刷位置的检测方法,适用于直接检测金属栅线印刷位置与选择性重扩散栅线印刷区的重合精度,可以实时在线检测栅线印刷位置精度并反馈偏差值,实现对位印刷的闭环控制。该检测方法同时也为采用图形识别技术和图形对位技术的选择性电极型晶硅太阳能电池丝网印刷设备提供了可直观衡量设备印刷精度的验证方法。此外,利用该检测方法可以实现对网板使用寿命的监测,提高网板和丝网印刷设备的使用率,降低生产成本,简化工艺控制。%This paper provides a method for detecting metal gate line printing position,registration accuracy for direct detection of metal gate line printing position and selective diffusion grid line printing area,can print position accuracy of real-time online detection of the gate line and feedback the deviation values,to achieve closed-loop metal grating pattern alignment printing control.The detection method at the same time as the selective electrode type amorphous silicon solar cell screen printing equipment using pattern recognition techniques and pattern alignment technology provides verification method can directly measure equipment printing precision.In addition,the detection method can be achieved on the monitor screen service life,improve the use of screen and screen printing equipment rate,reduce production cost, simplify the process control.

  14. Lightning Performance on Overhead Distribution Lines : After Improvement Field Observation

    Directory of Open Access Journals (Sweden)

    Reynaldo Zoro

    2009-11-01

    Full Text Available Two feeders of 20 kV overhead distribution lines which are located in a high lightning density area are chosen to be observed as a field study due to their good lightning performance after improvement of lightning protection system. These two feeders used the new overhead ground wire and new line arrester equipped with lightning counter on the main lines. The significant reduced of lines outages are reported. Study was carried out to observe these improvements by comparing to the other two feeders line which are not improved and not equipped yet with the ground wire and line arrester. These two feeders located in the nearby area. Two cameras were installed to record the trajectory of the lightning strikes on the improved lines. Lightning peak currents are measured using magnetic tape measurement system installed on the grounding lead of lightning arrester. Lightning overvoltage calculations are carried out by using several scenarios based on observation results and historical lightning data derived from lightning detection network. Lightning overvoltages caused by indirect or direct strikes are analyzed to get the lightning performance of the lines. The best scenario was chosen and performance of the lines were improved significantly by installing overhead ground wire and improvement of lightning arrester installation.

  15. Common Ground and Delegation

    DEFF Research Database (Denmark)

    Dobrajska, Magdalena; Foss, Nicolai Juul; Lyngsie, Jacob

    Much recent research suggests that firms need to increase their level of delegation to better cope with, for example, the challenges introduced by dynamic rapid environments and the need to engage more with external knowledge sources. However, there is less insight into the organizational...... preconditions of increasing delegation. We argue that key HR practices?namely, hiring, training and job-rotation?are associated with delegation of decision-making authority. These practices assist in the creation of shared knowledge conditions between managers and employees. In turn, such a ?common ground...

  16. Ground penetrating radar

    CERN Document Server

    Daniels, David J

    2004-01-01

    Ground-penetrating radar has come to public attention in recent criminal investigations, but has actually been a developing and maturing remote sensing field for some time. In the light of recent expansion of the technique to a wide range of applications, the need for an up-to-date reference has become pressing. This fully revised and expanded edition of the best-selling Surface-Penetrating Radar (IEE, 1996) presents, for the non-specialist user or engineer, all the key elements of this technique, which span several disciplines including electromagnetics, geophysics and signal processing. The

  17. Singlet Ground State Magnetism:

    DEFF Research Database (Denmark)

    Loidl, A.; Knorr, K.; Kjems, Jørgen;

    1979-01-01

    The magneticGamma 1 –Gamma 4 exciton of the singlet ground state system TbP has been studied by inelastic neutron scattering above the antiferromagnetic ordering temperature. Considerable dispersion and a pronounced splitting was found in the [100] and [110] directions. Both the band width...... and the splitting increased rapidly as the transition temperature was approached in accordance with the predictions of the RPA-theory. The dispersion is analysed in terms of a phenomenological model using interactions up to the fourth nearest neighbour....

  18. The LOFT Ground Segment

    DEFF Research Database (Denmark)

    Bozzo, E.; Antonelli, A.; Argan, A.;

    2014-01-01

    targets per orbit (~90 minutes), providing roughly ~80 GB of proprietary data per day (the proprietary period will be 12 months). The WFM continuously monitors about 1/3 of the sky at a time and provides data for about ~100 sources a day, resulting in a total of ~20 GB of additional telemetry. The LOFT...... we summarize the planned organization of the LOFT ground segment (GS), as established in the mission Yellow Book 1 . We describe the expected GS contributions from ESA and the LOFT consortium. A review is provided of the planned LOFT data products and the details of the data flow, archiving...

  19. Feasibility Lateral Position Under Endotracheal Intubation Intubation Laryngeal Mask Line Application%侧卧位下应用插管喉罩行气管插管的可行性

    Institute of Scientific and Technical Information of China (English)

    杨春艳

    2014-01-01

    目的:紧急情况下侧卧位应用传统喉镜建立气道是很困难的。我们进行了一项随机对照试验,探讨在侧卧位下应用插管喉罩建立通气及其气管插管的成功率。方法90例患者分为3组,每组30例,随机分为仰卧位,左侧卧位,右侧卧位。每组患者ASA分级为Ⅰ~Ⅱ级,择期在全身麻醉下行外科手术治疗,气道评估为非困难气道。诱导药物应用咪达唑仑、芬太尼、丙泊酚及阿曲库铵。诱导后置入插管喉罩,经插管喉罩盲探置入气管导管,分别记录成功率、所需时间以及需要调整的次数。数据采用卡方检验、方差分析及t检验。结果3组患者插管成功率为100%,插管时间以及调整次数无显著性差异,P<0.05。结论侧卧位患者在紧急情况下需要建立气道,插管喉罩在可行性、插管成功率、所需时间方面有绝对的优势,是临床上最佳选择。%[Abstrct] Objective Airway in patients in the lateral position in emergency application of conventional laryngoscopy has always been proven to be dififcult. We conducted a randomized controlled trial to explor the application and rate of ventilation and intubation in the lateral position via intubating laryngeal mask airway. Methods Ninety patients were divided into three groups of 30 patients each, positioned supine, right lateral, and left lateral randomly. Each group American Society of Anesth-esiologists grade Ⅰand Ⅱ, with normal airway posted for surgery under general anesthesia. Patients were induction withfentanyl, propofol and atrucrinium. ILMA was inserted andblind tracheal intubation via ILMA was done. The success rate, time taken and the number of adjusting maneuvers used for both procedures were recorded.The data

  20. EXPERIMENTS WITH UAS IMAGERY FOR AUTOMATIC MODELING OF POWER LINE 3D GEOMETRY

    Directory of Open Access Journals (Sweden)

    G. Jóźków

    2015-08-01

    Full Text Available The ideal mapping technology for transmission line inspection is the airborne LiDAR executed from helicopter platforms. It allows for full 3D geometry extraction in highly automated manner. Large scale aerial images can be also used for this purpose, however, automation is possible only for finding transmission line positions (2D geometry, and the sag needs to be estimated manually. For longer lines, these techniques are less expensive than ground surveys, yet they are still expensive. UAS technology has the potential to reduce these costs, especially if using inexpensive platforms with consumer grade cameras. This study investigates the potential of using high resolution UAS imagery for automatic modeling of transmission line 3D geometry. The key point of this experiment was to employ dense matching algorithms to appropriately acquired UAS images to have points created also on wires. This allowed to model the 3D geometry of transmission lines similarly to LiDAR acquired point clouds. Results showed that the transmission line modeling is possible with a high internal accuracy for both, horizontal and vertical directions, even when wires were represented by a partial (sparse point cloud.

  1. Superimposed particles in 1D ground states

    Energy Technology Data Exchange (ETDEWEB)

    Sueto, Andras, E-mail: suto@szfki.hu [Research Institute for Solid State Physics and Optics, Hungarian Academy of Sciences, PO Box 49, H-1525 Budapest (Hungary)

    2011-01-21

    For a class of nonnegative, range-1 pair potentials in one-dimensional continuous space we prove that any classical ground state of lower density {>=}1 is a tower-lattice, i.e. a lattice formed by towers of particles the heights of which can differ only by 1, and the lattice constant is 1. The potential may be flat or may have a cusp at the origin; it can be continuous, but its derivative has a jump at 1. The result is valid on finite intervals or rings of integer length and on the whole line.

  2. OPTIMIZATION OF TRANSIENT FEEDING TO PARALLEL-PLATE TRANSMISSION LINES FROM COAXIAL LINE

    Institute of Scientific and Technical Information of China (English)

    Tian Chunming; Wang Jianguo; Meng Fenxia; Zhang Maoyu; Ge Debiao

    2001-01-01

    The transient feeding to parallel-plate transmission lines from coaxial line is optimized by using the Finite-Difference Time-Domain (FDTD) method and a simple FDTD feed model. Observing the reflected voltages, this letter presents the optimal feeding position and ratio of width to height for a given input impedance of the coaxial line.

  3. Modeling and Simulation Analysis of Power Frequency Electric Field of UHV AC Transmission Line

    Directory of Open Access Journals (Sweden)

    Chen Han

    2015-02-01

    Full Text Available In order to study the power frequency electric field of UHV AC transmission lines, this paper which models and calculates using boundary element method simulates various factors influencing the distribution of the power frequency electric field, such as the conductor arrangement, the over-ground height, the split spacing and the sub conductor radius. Different influence of various factors on the electric field distribution will be presented. In a single loop, using VVV triangular arrangement is the most secure way; in a dual loop, the electric field intensity using reverse phase sequence is weaker than that using positive phase sequence. Elevating the over-ground height and reducing the conductor split spacing will both weaken the electric field intensity, while the change of sub conductor radius can hardly cause any difference. These conclusions are important for electric power company to detect circuit.

  4. Ground Vehicle Navigation Using Magnetic Field Variation

    Science.gov (United States)

    Shockley, Jeremiah A.

    The Earth's magnetic field has been the bedrock of navigation for centuries. The latest research highlights the uniqueness of magnetic field measurements based on position due to large scale variations as well as localized perturbations. These observable changes in the Earth's magnetic field as a function of position provide distinct information which can be used for navigation. This dissertation describes ground vehicle navigation exploiting variation in Earth's magnetic field using a self-contained navigation system consisting of only a magnetometer and magnetic field maps. In order to achieve navigation, effective calibration enables repeatable magnetic field measurements from different vehicles and facilitates mapping of the observable magnetic field as a function of position. A new modified ellipsoid calibration technique for strapdown magnetometers in large vehicles is described, as well as analysis of position measurement generation comparing a multitude of measurement compositions using existing and newly developed likelihood techniques. Finally, navigation solutions are presented using both a position measurement and direct incorporation of the magnetometer measurements via a particle filter to demonstrate road navigation in three different environments. Emphatically, the results affirm that navigation using magnetic field variation in ground vehicles is viable and achieves adequate performance for road level navigation.

  5. Nursing of Patients with PET-CT Examination Combined CT Positioning Reinforce Line Radiation%正电子发射型计算机断层扫描仪/计算机体层扫描检查联合CT定位行强化放疗患者的护理

    Institute of Scientific and Technical Information of China (English)

    孙淑梅; 高莹; 许海燕; 赵恩

    2015-01-01

    Objective To discuss the nursing of patients with PET-CT examination combined CT positioning rein-force line radiation.Methods Clinical data of 5 2 cases with PET-CT examination combined CT positioning were analyzed retrospectively,and analysis its nursing measures.Results The result was false read because of the body shake during examination in two patients and 1 patient has drug leakage.The other 49 patients successfully finished the treatment.Conclusion The reasonable nursing procedure is the gauraantee of the successful finish the PET-CT examination combined CT positioning reinforce line radiation,which is worth for clinical trail.%目的:探讨正电子发射型计算机断层扫描仪/计算机体层扫描(positron emission tomography/computed tomography, PET/CT)检查联合CT定位行强化放疗患者的护理方法。方法回顾性分析了2013年7月至2014年5月在济南军区总医院核医学科实施PET-CT检查联合CT定位强化的52例患者的临床资料,总结其护理方法。结果52例患者中2例患者因检查过程中身体抖动,影响结果判读;1例患者在高压推注碘佛醇注射液时药液渗漏,其余49例患者顺利完成PET-CT联合CT定位强化放疗。结论合理的护理流程是患者顺利进行PET-CT联合CT定位强化放疗的保障,值得推广。

  6. Lightning simulation of a combined overhead line/cable connected GIS

    DEFF Research Database (Denmark)

    Kessel, Jakob; Atlason, Vioir; Bak, Claus Leth;

    2008-01-01

    at the surge arrester grounding in the overhead line/cable transition and different length of the connection cable between the transformer and the GIS busbar with a SA implemented. Those simulations are conducted for different positions of the circuit breaker present at the GIS busbar. The lightning current...... required to cause inadmissible voltages at the transformer is evaluated and the MTBF is found for different cases. With the circuit breaker at the GIS busbar in closed position results indicate that SF does not cause inadmissible voltages to appear at the trasformer. However, BFO caused by a lightning...... stroke of extremely high magnitude can cause inadmissible voltages to appear at the transformer. With the circuit breaker at the GIS busbar in open position results indicate that both SF and BFO can cause inadmissible voltages to appear at the tranformer. A risk assessment based on the simulation results...

  7. Ground-Ground Data Communication-Assisted Planning and Coordination: Shorter Verbal Communications

    Science.gov (United States)

    Kessell, Angela Mary; Lee, Paul U.; Smith, Nancy M.; Lee, Hwasoo Eric

    2010-01-01

    A human-in-the-loop simulation was conducted to investigate the operational feasibility, technical requirements, and potential improvement in airspace efficiency of adding a Multi-Sector Planner position. A subset of the data from that simulation is analyzed here to determine the impact, if any, of ground-ground data communication (Data Comm) on verbal communication and coordination for multi-sector air traffic management. The results suggest that the use of Data Comm significantly decreases the duration of individual verbal communications. The results also suggest that the use of Data Comm, as instantiated in the current simulation, does not obviate the need for accompanying voice calls.

  8. Stable line defects in silicene

    Science.gov (United States)

    Ghosh, Dibyajyoti; Parida, Prakash; Pati, Swapan K.

    2015-11-01

    Line defects in two-dimensional (2D) materials greatly modulate various properties of their pristine form. Using ab initio molecular dynamics (AIMD) simulations, we investigate the structural reconstructions of different kinds of grain boundaries in the silicene sheets. It is evident that depending upon the presence of silicon adatoms and edge shape of grain boundaries (i.e., armchair or zigzag), stable extended line defects (ELDs) can be introduced in a controlled way. Further studies show the stability of these line-defects in silicene, grown on Ag(111) surface at room-temperature. Importantly, unlike most of the 2D sheet materials such as graphene and hexagonal boron nitride, 5-5-8 line defects modify the nonmagnetic semimetallic pristine silicene sheet to spin-polarized metal. As ferromagnetically ordered magnetic moments remain strongly localized at the line defect, a one-dimensional spin channel gets created in silicene. Interestingly, these spin channels are quite stable because, unlike the edge of nanoribbons, structural reconstruction or contamination cannot destroy the ordering of magnetic moments here. Zigzag silicene nanoribbons with a 5-5-8 line defect also exhibit various interesting electronic and magnetic properties depending upon their width as well as the nature of the magnetic coupling between edge and defect spin states. Upon incorporation of other ELDs, such as 4-4-4 and 4-8 defects, 2D sheets and nanoribbons of silicene show a nonmagnetic metallic or semiconducting ground state. Highlighting the controlled formation of ELDs and consequent emergence of technologically important properties in silicene, we propose new routes to realize silicene-based nanoelectronic and spintronic devices.

  9. Designing as middle ground

    DEFF Research Database (Denmark)

    Nickelsen, Niels Christian Mossfeldt; Binder, Thomas

    2010-01-01

    The theoretical background in this chapter is science and technology studies and actor network theory, enabling investigation of heterogeneity, agency and perfor-mative effects through ‘symmetric’ analysis. The concept of design is defined as being imaginative and mindful to a number of actors...... in a network of humans and non-humans, highlighting that design objects and the designer as an authority are constructed throughout this endeavour. The illustrative case example is drawn from product development in a rubber valve factory in Jutland in Denmark. The key contribution to a general core of design...... research is an articulation of design activity taking place as a middle ground and as an intermixture between a ‘scientific’ regime of knowledge transfer and a capital ‘D’ ‘Designerly’ regime of authoring....

  10. Wind-induced ground motion

    Science.gov (United States)

    Naderyan, Vahid; Hickey, Craig J.; Raspet, Richard

    2016-02-01

    Wind noise is a problem in seismic surveys and can mask the seismic signals at low frequency. This research investigates ground motions caused by wind pressure and shear stress perturbations on the ground surface. A prediction of the ground displacement spectra using the measured ground properties and predicted pressure and shear stress at the ground surface is developed. Field measurements are conducted at a site having a flat terrain and low ambient seismic noise. Triaxial geophones are deployed at different depths to study the wind-induced ground vibrations as a function of depth and wind velocity. Comparison of the predicted to the measured wind-induced ground displacement spectra shows good agreement for the vertical component but significant underprediction for the horizontal components. To validate the theoretical model, a test experiment is designed to exert controlled normal pressure and shear stress on the ground using a vertical and a horizontal mass-spring apparatus. This experiment verifies the linear elastic rheology and the quasi-static displacements assumptions of the model. The results indicate that the existing surface shear stress models significantly underestimate the wind shear stress at the ground surface and the amplitude of the fluctuation shear stress must be of the same order of magnitude as the normal pressure. Measurement results show that mounting the geophones flush with the ground provides a significant reduction in wind noise on all three components of the geophone. Further reduction in wind noise with depth of burial is small for depths up to 40 cm.

  11. Automatic Omega Station and LOP (Line of Position) Selection,

    Science.gov (United States)

    1987-09-01

    checkiNLOPiINLOPI; double Dinv[NLOPJ[NLOPJ, Hinter [Nj(NLOPJ; /* Scratch vars */ register int i,j,k; **--INITIALIZE WORK ARRAYS for (j=O; j < NSTNS; j+e...TEST2 mti sa olw:\\" Nprintf("\\t Inverse(D*R*Dt)marxiasflo:\

  12. Movable Ground Based Recovery System for Reuseable Space Flight Hardware

    Science.gov (United States)

    Sarver, George L. (Inventor)

    2013-01-01

    A reusable space flight launch system is configured to eliminate complex descent and landing systems from the space flight hardware and move them to maneuverable ground based systems. Precision landing of the reusable space flight hardware is enabled using a simple, light weight aerodynamic device on board the flight hardware such as a parachute, and one or more translating ground based vehicles such as a hovercraft that include active speed, orientation and directional control. The ground based vehicle maneuvers itself into position beneath the descending flight hardware, matching its speed and direction and captures the flight hardware. The ground based vehicle will contain propulsion, command and GN&C functionality as well as space flight hardware landing cushioning and retaining hardware. The ground based vehicle propulsion system enables longitudinal and transverse maneuverability independent of its physical heading.

  13. 2011 Ground Testing Highlights Article

    Science.gov (United States)

    Ross, James C.; Buchholz, Steven J.

    2011-01-01

    Two tests supporting development of the launch abort system for the Orion MultiPurpose Crew Vehicle were run in the NASA Ames Unitary Plan wind tunnel last year. The first test used a fully metric model to examine the stability and controllability of the Launch Abort Vehicle during potential abort scenarios for Mach numbers ranging from 0.3 to 2.5. The aerodynamic effects of the Abort Motor and Attitude Control Motor plumes were simulated using high-pressure air flowing through independent paths. The aerodynamic effects of the proximity to the launch vehicle during the early moments of an abort were simulated with a remotely actuated Service Module that allowed the position relative to the Crew Module to be varied appropriately. The second test simulated the acoustic environment around the Launch Abort Vehicle caused by the plumes from the 400,000-pound thrust, solid-fueled Abort Motor. To obtain the proper acoustic characteristics of the hot rocket plumes for the flight vehicle, heated Helium was used. A custom Helium supply system was developed for the test consisting of 2 jumbo high-pressure Helium trailers, a twelve-tube accumulator, and a 13MW gas-fired heater borrowed from the Propulsion Simulation Laboratory at NASA Glenn Research Center. The test provided fluctuating surface pressure measurements at over 200 points on the vehicle surface that have now been used to define the ground-testing requirements for the Orion Launch Abort Vehicle.

  14. Central line infections - hospitals

    Science.gov (United States)

    ... infection; Central venous catheter - infection; CVC - infection; Central venous device - infection; Infection control - central line infection; Nosocomial infection - central line infection; Hospital acquired ...

  15. Analysis on Electric Field Around HVAC-HVDC Hybrid Transmission Lines%Analysis on Electric Field Around HVAC-HVDC Hybrid Transmission Lines

    Institute of Scientific and Technical Information of China (English)

    LI Qian; LIU Jun-xiang; LI Hua; LIN Fu-chang

    2011-01-01

    As the transmission line corridors become more and more rare in China, it is now inevitable for people to construct HVAC-HVDC hybrid transmission lines. The research on the electric field around the transmission lines plays an important role in evaluating the electromagnetic environment nearby. However, few existing research now considered the mutual effect of HVAC-HVDC hybrid transmission lines. Thus, this research designed a program based on windows, which calculated the surface voltage gradient on the transmission lines and the electric field at ground level respectively. This research calculated the surface voltage gradient on the transmission lines by applying the improved method of successive images. For the electric field at ground level under AC transmission line, simula- tion charge method is used, while for the electric field at the ground level under DC transmission lines, deutsch as- sumption method is used. Comparing the results generated by the calculation with those in published literature, the program is reliable. Taking 500 kV transmission lines as an example, when considering the mutual effect of the HVAC-HVDC'lines, the amplitude of the surface voltage gradient will increase by about 10% and the amplitude of the electric field at ground level will increase by about 8%, making the mutual effect of the AC and DC lines unneglectable. Larger part of the electric field at ground level under hybrid lines is produced by the DC line. Thus, in order to control the electric field at ground level under hybrid lines, it should pay more attention on that produced by the DC line.

  16. Apparatus and method for grounding compressed fuel fueling operator

    Science.gov (United States)

    Cohen, Joseph Perry; Farese, David John; Xu, Jianguo

    2002-06-11

    A safety system for grounding an operator at a fueling station prior to removing a fuel fill nozzle from a fuel tank upon completion of a fuel filling operation is provided which includes a fuel tank port in communication with the fuel tank for receiving and retaining the nozzle during the fuel filling operation and a grounding device adjacent to the fuel tank port which includes a grounding switch having a contact member that receives physical contact by the operator and where physical contact of the contact member activates the grounding switch. A releasable interlock is included that provides a lock position wherein the nozzle is locked into the port upon insertion of the nozzle into the port and a release position wherein the nozzle is releasable from the port upon completion of the fuel filling operation and after physical contact of the contact member is accomplished.

  17. Laser Frequency-Modulated Spectroscopy of a Laser-Guided Plasma in Sodium Vapor: Line Positions for NaH (A1Σ+-X1Σ+), Na (9-13dand 11-14s), and Ar (5p-4s)

    Science.gov (United States)

    Bahns, J. T.; Tsai, C. C.; Ji, B.; Kim, J. T.; Zhao, G.; Stwalley, W. C.; Bloch, J. C.; Field, R. W.

    1997-12-01

    Laser frequency-modulated (FM) spectroscopy has been used as an axial probe of a laser-guided electric discharge in sodium-argon vapor contained in an optically accessible metal heat pipe oven. Absorption measurements in the region 23 106-23 881 cm-1provided accurate line positions (±<0.006 cm-1) for 141 transitions in thev‧ = 3-8 ←v″ = 0 andv‧ = 5-9 ←v″ = 1 bands of NaH (A1Σ+-X1Σ+). In addition, 18 transitions of Na (3pto 9-13dand 11-14s) and 10 of argon (5p-4s) were measured. Analysis of the spectrum indicates that perhaps all absorption signals are due to neutrals NaH, Na, and Ar and are observed via "population" modulation.

  18. Burial Ground Expansion Hydrogeologic Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Gaughan , T.F.

    1999-02-26

    Sirrine Environmental Consultants provided technical oversight of the installation of eighteen groundwater monitoring wells and six exploratory borings around the location of the Burial Ground Expansion.

  19. Relativistic Positioning Systems: Numerical Simulations

    CERN Document Server

    Puchades, Neus

    2014-01-01

    The motion of satellite constellations similar to GPS and Galileo is numerically simulated and, then, the region where bifurcation (double positioning) occurs is appropriately represented. In the cases of double positioning, the true location may be found using additional information (angles or times). The zone where the Jacobian, J, of the transformation from inertial to emission coordinates vanishes is also represented and interpreted. It is shown that the uncertainties in the satellite world lines produce positioning errors, which depend on the value of |J|. The smaller this quantity the greater the expected positioning errors. Among all the available 4-tuples of satellites, the most appropriate one -for a given location- should minimize positioning errors (large enough |J| values) avoiding bifurcation. Our study is particularly important to locate objects which are far away from Earth, e.g., satellites.

  20. On what grounds?

    DEFF Research Database (Denmark)

    Markussen, Thomas; Krogh, Peter Gall; Bang, Anne Louise

    2015-01-01

    Research through design is a murky field and there is an increasing interest in understanding its varied practices and methodology. In the research literature that is initially reviewed in this paper two positions are located as the most dominant representing opposite opinions concerning the natu...