Proven Innovations and New Initiatives in Ground System Development: Reducing Costs in the Ground System

Science.gov (United States)

Gunn, Jody M.

2006-01-01

The state-of-the-practice for engineering and development of Ground Systems has evolved significantly over the past half decade. Missions that challenge ground system developers with significantly reduced budgets in spite of requirements for greater and previously unimagined functionality are now the norm. Making the right trades early in the mission lifecycle is one of the key factors to minimizing ground system costs. The Mission Operations Strategic Leadership Team at the Jet Propulsion Laboratory has spent the last year collecting and working through successes and failures in ground systems for application to future missions.

Development of mine explosion ground truth smart sensors

Energy Technology Data Exchange (ETDEWEB)

Taylor, Steven R. [Rocky Mountain Geophysics, Inc., Los Alamos, NM (United States); Harben, Phillip E. [Rocky Mountain Geophysics, Inc., Los Alamos, NM (United States); Jarpe, Steve [Jarpe Data Solutions, Prescott, AZ (United States); Harris, David B. [Deschutes Signal Processing, Maupin, OR (United States)

2015-09-14

Accurate seismo-acoustic source location is one of the fundamental aspects of nuclear explosion monitoring. Critical to improved location is the compilation of ground truth data sets for which origin time and location are accurately known. Substantial effort by the National Laboratories and other seismic monitoring groups have been undertaken to acquire and develop ground truth catalogs that form the basis of location efforts (e.g. Sweeney, 1998; Bergmann et al., 2009; Waldhauser and Richards, 2004). In particular, more GT1 (Ground Truth 1 km) events are required to improve three-dimensional velocity models that are currently under development. Mine seismicity can form the basis of accurate ground truth datasets. Although the location of mining explosions can often be accurately determined using array methods (e.g. Harris, 1991) and from overhead observations (e.g. MacCarthy et al., 2008), accurate origin time estimation can be difficult. Occasionally, mine operators will share shot time, location, explosion size and even shot configuration, but this is rarely done, especially in foreign countries. Additionally, shot times provided by mine operators are often inaccurate. An inexpensive, ground truth event detector that could be mailed to a contact, placed in close proximity (< 5 km) to mining regions or earthquake aftershock regions that automatically transmits back ground-truth parameters, would greatly aid in development of ground truth datasets that could be used to improve nuclear explosion monitoring capabilities. We are developing an inexpensive, compact, lightweight smart sensor unit (or units) that could be used in the development of ground truth datasets for the purpose of improving nuclear explosion monitoring capabilities. The units must be easy to deploy, be able to operate autonomously for a significant period of time (> 6 months) and inexpensive enough to be discarded after useful operations have expired (although this may not be part of our business

Proven Innovations and New Initiatives in Ground System Development

Science.gov (United States)

Gunn, Jody M.

2006-01-01

The state-of-the-practice for engineering and development of Ground Systems has evolved significantly over the past half decade. Missions that challenge ground system developers with significantly reduced budgets in spite of requirements for greater and previously unimagined functionality are now the norm. Making the right trades early in the mission lifecycle is one of the key factors to minimizing ground system costs. The Mission Operations Strategic Leadership Team at the Jet Propulsion Laboratory has spent the last year collecting and working through successes and failures in ground systems for application to future missions.

Relational grounding facilitates development of scientifically useful multiscale models

Directory of Open Access Journals (Sweden)

Lam Tai

2011-09-01

Full Text Available Abstract We review grounding issues that influence the scientific usefulness of any biomedical multiscale model (MSM. Groundings are the collection of units, dimensions, and/or objects to which a variable or model constituent refers. To date, models that primarily use continuous mathematics rely heavily on absolute grounding, whereas those that primarily use discrete software paradigms (e.g., object-oriented, agent-based, actor typically employ relational grounding. We review grounding issues and identify strategies to address them. We maintain that grounding issues should be addressed at the start of any MSM project and should be reevaluated throughout the model development process. We make the following points. Grounding decisions influence model flexibility, adaptability, and thus reusability. Grounding choices should be influenced by measures, uncertainty, system information, and the nature of available validation data. Absolute grounding complicates the process of combining models to form larger models unless all are grounded absolutely. Relational grounding facilitates referent knowledge embodiment within computational mechanisms but requires separate model-to-referent mappings. Absolute grounding can simplify integration by forcing common units and, hence, a common integration target, but context change may require model reengineering. Relational grounding enables synthesis of large, composite (multi-module models that can be robust to context changes. Because biological components have varying degrees of autonomy, corresponding components in MSMs need to do the same. Relational grounding facilitates achieving such autonomy. Biomimetic analogues designed to facilitate translational research and development must have long lifecycles. Exploring mechanisms of normal-to-disease transition requires model components that are grounded relationally. Multi-paradigm modeling requires both hyperspatial and relational grounding.

Theory of Economic Development (Secondary Stage)

OpenAIRE

Mashkoor, Aasim; Ahmed, Ovais

2015-01-01

This is a secondary stage of theory of economic development. This research study is covering the secondary phase of development which rules the tactical plans of the main strategy. In this stage, the social and economical demands varies from country to country and we have developed the theory according to the Pakistani economic conditions. It requires great a lot of technical and strategic analysis to chose the accurate plans accordingly.

Developing and implementing institutional controls for ground water remediation

International Nuclear Information System (INIS)

Ulland, L.M.; Cooper, M.G.

1995-01-01

The US DOE has initiated its Ground Water Project as the second phase of the Uranium Mill Tailings Remedial Action (UMTRA) Project authorized under the Uranium Mill Tailings Radiation Control Act (UMTRCA). In the Ground Water Project, the DOE must reduce risk from ground water contaminated by uranium mill processing activities at 24 inactive processing sites by meeting the US EPA standards. The UMTRCA also requires consistency with federal statutes such as the Resource Conservation and Recovery Act (RCRA). The use of institutional controls to reduce risk from contaminated ground water is one element of compliance with standards and the protection of public health and the environment. Institutional controls are active or passive measures that reduce exposure to risks by preventing intrusion or restricting direct access to an area, or restricting access to the contamination through secondary means. Because of inconsistent regulations and multi-party authorities for ground water management, the key to selecting and implementing effective institutional controls lies with developing a consensus between the parties responsible for ground water remediation; those with authority to implement, monitor, and maintain institutional controls; and those facing the risks from contaminated ground water. These parties must develop a consensus for an institutional control program that meets minimum regulatory requirements and protects public health and the environment. Developing consensus and implementing a successful institutional controls program was achieved by the DOE during the cleanup of uranium mill tailings. An effective institutional controls program can also be developed to protect against risks from contaminated ground water. Consensus building and information transmission are the critical elements of an institutional control program that protects human health and the environment from risks associated with ground water contamination

Energy regulation in context: Free-living female arctic ground squirrels modulate the relationship between thyroid hormones and activity among life history stages.

Science.gov (United States)

Wilsterman, Kathryn; Buck, C Loren; Barnes, Brian M; Williams, Cory T

2015-09-01

Thyroid hormones (THs), key regulators of lipid and carbohydrate metabolism, are likely modulators of energy allocation within and among animal life history stages. Despite their role in modulating metabolism, few studies have investigated whether THs vary among life history stages in free-living animals or if they exhibit stage-specific relationships to total energy expenditure and activity levels. We measured plasma total triiodothyronine (tT3) and thyroxine (tT4) at four, discrete life history stages of female arctic ground squirrels from two different populations in northern Alaska to test whether plasma THs correlate with life history stage-specific changes in metabolic rate and energy demand. We also tested whether THs explained individual variation in aboveground activity levels within life history stages. T3 peaked during lactation and was lowest during pre-hibernation fattening, consistent with known changes in basal metabolism and core body temperature. In contrast, T4 was elevated shortly after terminating hibernation but remained low and stable across other life-history stages in the active season. THs were consistently higher in the population that spent more time above-ground but the relationship between THs and activity varied among life history stages. T3 was positively correlated with activity only during lactation (r(2)=0.50) whereas T4 was positively correlated with activity immediately following lactation (r(2)=0.48) and during fattening (r(2)=0.53). Our results support the hypothesis that THs are an important modulator of basal metabolism but also suggest that the relationship between THs and activity varies among life history stages. Copyright © 2015 Elsevier Inc. All rights reserved.

High-speed ground transportation development outside United States

Energy Technology Data Exchange (ETDEWEB)

Eastham, T.R. [Queen`s Univ., Kingston, Ontario (United Kingdom)

1995-09-01

This paper surveys the state of high-speed (in excess of 200 km/h) ground-transportation developments outside the United States. Both high-speed rail and Maglev systems are covered. Many vehicle systems capable of providing intercity service in the speed range 200--500 km/h are or will soon be available. The current state of various technologies, their implementation, and the near-term plans of countries that are most active in high-speed ground transportation development are reported.

Development Ground Fault Detecting System for D.C Voltage Line

Energy Technology Data Exchange (ETDEWEB)

Kim Taek Soo; Song Ung Il; Gwon, Young Dong; Lee Hyoung Kee [Korea Electric Power Research Institute, Taejon (Korea, Republic of)

1996-12-31

It is necessary to keep the security of reliability and to maximize the efficiency of maintenance by prompt detection of a D.C feeder ground fault point at the built ed or a building power plants. At present, the most of the power plants are set up the ground fault indicator lamp in the monitor room. If a ground fault occurs on DC voltage feeder, a current through the ground fault relay is adjusted and the lamps have brightened while the current flows the relay coil. In order to develop such a system, it is analyzed a D.C feeder ground circuit theoretically and studied a principles which can determine ground fault point or a polarity discrimination and a phase discrimination of the line. So, the developed system through this principles can compute a resistance ground fault current and a capacitive ground fault current. It shows that the system can defect a ground fault point or a bad insulated line by measuring a power plant D.C feeder insulation resistance at the un interruptible power status, and therefore the power plant could protect an unexpected service interruption . (author). 18 refs., figs.

Development costs for a nuclear electric propulsion stage.

Science.gov (United States)

Mondt, J. F.; Prickett, W. Z.

1973-01-01

Development costs are presented for an unmanned nuclear electric propulsion (NEP) stage based upon a liquid metal cooled, in-core thermionic reactor. A total of 120 kWe are delivered to the thrust subsystem which employs mercury ion engines for electric propulsion. This study represents the most recent cost evaluation of the development of a reactor power system for a wide range of nuclear space power applications. These include geocentric, and outer planet and other deep space missions. The development program is described for the total NEP stage, based upon specific development programs for key NEP stage components and subsystems.

Social Development Training Project. Stage I and Stage II. [The Granville Project].

Science.gov (United States)

Riches, Vivienne C., Ed.

The book presents a training program developed at the Granville Work Preparation Centre in Australia, to teach mildly retarded adolescents basic social skills and competencies. The program is divided into two stages, with a total of 17 different skill areas. Stage 1 covers self-awareness, social/interpersonal skills, relaxation and behavioral self…

Coronary heart disease patients transitioning to a normal life: perspectives and stages identified through a grounded theory approach.

Science.gov (United States)

Najafi Ghezeljeh, Tahereh; Yadavar Nikravesh, Mansoureh; Emami, Azita

2014-02-01

To explore how Iranian patients with coronary heart disease experience their lives. Coronary heart disease is a leading cause of death in Iran and worldwide. Understanding qualitatively how patients experience the acute and postacute stages of this chronic condition is essential knowledge for minimising the negative consequences of coronary heart disease. Qualitative study using grounded theory for the data analysis. Data for this study were collected through individual qualitative interviews with 24 patients with coronary heart disease, conducted between January 2009 and January 2011. Patients with angina pectoris were selected for participation through purposive sampling, and sample size was determined by data saturation. Data analysis began with initial coding and continued with focused coding. Categories were determined, and the core category was subsequently developed and finalised. The main categories of the transition from acute phase to a modified or 'new normal' life were: (1) Loss of normal life. Experiencing emotions and consequences of illness; (2) Coming to terms. Using coping strategies; (3) Recreating normal life. Healthcare providers must correctly recognise the stages of transition patients navigate while coping with coronary heart disease to support and educate them appropriately throughout these stages. Patients with coronary heart disease lose their normal lives and must work towards recreating a revised life using coping strategies that enable them to come to terms with their situations. By understanding Iranian patients' experiences, healthcare providers and especially nurses can use the information to support and educate patients with coronary heart disease on how to more effectively deal with their illness and its consequences. © 2013 John Wiley & Sons Ltd.

INNOVATION DIFFUSION THEORY MAIN DEVELOPMENT STAGES

Directory of Open Access Journals (Sweden)

S. V. Lisafiev

2011-01-01

Full Text Available Abstract: Main innovation diffusion development theory stages are: Rogers model of moving new products to the market including characteristics of its segments; mathematic substantiation of this model by Bass; Moor model taking into account gaps between adjacent market segments; Goldenberg model making it possible to predict sales drops at new product life cycle initial stages. It is reasonable to use this theory while moving innovative products to the market.

The process of accepting breast cancer among Chinese women: A grounded theory study.

Science.gov (United States)

Chen, Shuang-Qin; Liu, Jun-E; Li, Zhi; Su, Ya-Li

2017-06-01

To describe the process by which Chinese women accept living with breast cancer. Individual interviews were conducted with 18 Chinese women who completed breast cancer treatment. Data were collected from September 2014 to January 2015 at a large tertiary teaching hospital in Beijing, China. In this grounded theory study, data were analyzed using constant comparative and coding analysis methods. In order to explain the process of accepting having breast cancer among women in China through the grounded theory study, a model that includes 5 axial categories was developed. Cognitive reconstruction emerged as the core category. The extent to which the women with breast cancer accepted having the disease was found to increase with the treatment stage and as their treatment stage progressed with time. The accepting process included five stages: non-acceptance, passive acceptance, willingness to accept, behavioral acceptance, and transcendence of acceptance. Our study using grounded theory study develops a model describing the process by which women accept having breast cancer. The model provides some intervention opportunities at every point of the process. Copyright © 2017. Published by Elsevier Ltd.

Effects of energy development on ground water quality: an overview and preliminary assessment

International Nuclear Information System (INIS)

Parker, W.M. III; Yin, S.C.L.; Davis, M.J.; Kutz, W.J.

1981-07-01

A preliminary national overview of the various effects on ground water quality likely to result from energy development. Based on estimates of present and projected energy-development activities, those regions of the country are identified where ground water quality has the potential for being adversely affected. The general causes of change in ground water quality are reviewed. Specific effects on ground water quality of selected energy technologies are discussed, and some case-history material is provided. A brief overview of pertinent legislation relating to the protection and management of ground water quality is presented. Six methodologies that have some value for assessing the potential effects on ground water quality of energy development activities are reviewed. A method of identifying regions in the 48 contiguous states where there is a potential for ground water quality problems is described and then applied

On development and improvement of evaluation techniques for seismic ground motion

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-08-15

Issues regarding evaluation of active fault and ground motion for formulation of design basis ground motion (Ss) were prescribed in 'NSC seismic and tsunami safety reviewing manual' in 2012. Moreover, Nuclear Regulation Authority (NRA) is establishing the new seismic safety guideline. In this theme following four subjects were investigated to resolve the important problems for ground motion evaluation, (1) advanced evaluation of ground motion using fault model and uncertainty; (2) improving evaluation of ground motion using attenuation relation of response spectrum; (3) development of advanced and generic techniques for ground motion observation and observation tool in deep borehole; (4) improving the evaluation of site effect and seismic wave propagation characteristics. In addition as emergency requirements from NRA following two subjects were also investigated; (5) hazard evaluation development on fault displacement; (6) ground motion evaluation at near-by source location. Obtained results will be reflected not only in the domestic guideline established by NRA but in the national safety review and also in the safety standard guidelines of the International Atomic Energy Agency (IAEA) through its Extra-Budgetary Program (EBP), thereby contributing to technical cooperation in global nuclear seismic safety. (author)

Affordable Development and Demonstration of a Small Nuclear Thermal Rocket (NTR) Engine and Stage: How Small Is Big Enough?

Science.gov (United States)

Borowski, Stanley K.; Sefcik, Robert J.; Fittje, James E.; McCurdy, David R.; Qualls, Arthur L.; Schnitzler, Bruce G.; Werner, James E.; Weitzberg, Abraham; Joyner, Claude R.

2016-01-01

89-centimeters) -long FE, the SNRE's larger diameter core contains approximately 300 more FEs needed to produce an additional 210 thermal megawatts of power. To reduce the cost of the FTD mission, a simple one-burn lunar flyby mission was considered to reduce the liquid hydrogen (LH2) propellant loading, the stage size and complexity. Use of existing and flight proven liquid rocket and stage hardware (e.g., from the RL10B-2 engine and Delta Cryogenic Second Stage) was also maximized to further aid affordability. This paper examines the pros and cons of using these two small engine options, including their potential to support future human exploration missions to the Moon, near Earth asteroids (NEA), and Mars, and recommends a preferred size. It also provides a preliminary assessment of the key activities, development options, and schedule required to affordably build, ground test and fly a small NTR engine and stage within a 10-year timeframe.

Affordable Development and Demonstration of a Small NTR Engine and Stage: How Small is Big Enough?

Science.gov (United States)

Borowski, Stanley K.; Sefcik, Robert J.; Fittje, James E.; McCurdy, David R.; Qualls, Arthur L.; Schnitzler, Bruce G.; Werner, James E.; Weitzberg (Abraham); Joyner, Claude R.

2015-01-01

The Nuclear Thermal Rocket (NTR) derives its energy from fission of uranium-235 atoms contained within fuel elements that comprise the engine's reactor core. It generates high thrust and has a specific impulse potential of approximately 900 seconds - a 100% increase over today's best chemical rockets. The Nuclear Thermal Propulsion (NTP) project, funded by NASA's AES program, includes five key task activities: (1) Recapture, demonstration, and validation of heritage graphite composite (GC) fuel (selected as the "Lead Fuel" option); (2) Engine Conceptual Design; (3) Operating Requirements Definition; (4) Identification of Affordable Options for Ground Testing; and (5) Formulation of an Affordable Development Strategy. During FY'14, a preliminary DDT&E plan and schedule for NTP development was outlined by GRC, DOE and industry that involved significant system-level demonstration projects that included GTD tests at the NNSS, followed by a FTD mission. To reduce cost for the GTD tests and FTD mission, small NTR engines, in either the 7.5 or 16.5 klbf thrust class, were considered. Both engine options used GC fuel and a "common" fuel element (FE) design. The small approximately 7.5 klbf "criticality-limited" engine produces approximately 157 megawatts of thermal power (MWt) and its core is configured with parallel rows of hexagonal-shaped FEs and tie tubes (TTs) with a FE to TT ratio of approximately 1:1. The larger approximately 16.5 klbf Small Nuclear Rocket Engine (SNRE), developed by LANL at the end of the Rover program, produces approximately 367 MWt and has a FE to TT ratio of approximately 2:1. Although both engines use a common 35 inch (approximately 89 cm) long FE, the SNRE's larger diameter core contains approximately 300 more FEs needed to produce an additional 210 MWt of power. To reduce the cost of the FTD mission, a simple "1-burn" lunar flyby mission was considered to reduce the LH2 propellant loading, the stage size and complexity. Use of existing and

Dual odontogenic origins develop at the early stage of rat maxillary incisor development.

Science.gov (United States)

Kriangkrai, Rungarun; Iseki, Sachiko; Eto, Kazuhiro; Chareonvit, Suconta

2006-03-01

Developmental process of rat maxillary incisor has been studied through histological analysis and investigation of tooth-related gene expression patterns at initial tooth development. The tooth-related genes studied here are fibroblast growth factor-8 (Fgf-8), pituitary homeobox gene-2 (Pitx-2), sonic hedgehog (Shh), muscle segment homeobox-1 (Msx-1), paired box-9 (Pax-9) and bone morphogenetic protein-4 (Bmp-4). The genes are expressed in oral epithelium and/or ectomesenchyme at the stage of epithelial thickening to the early bud stage of tooth development. Both the histological observation and tooth-related gene expression patterns during early stage of maxillary incisor development demonstrate that dual odontogenic origins aligned medio-laterally in the medial nasal process develop, subsequently only single functional maxillary incisor dental placode forms. The cascade of tooth-related gene expression patterns in rat maxillary incisor studied here is quite similar to those of the previous studies in mouse mandibular molar, even though the origins of oral epithelium and ectomesenchyme involved in development of maxillary incisor and mandibular molar are different. Thus, we conclude that maxillary incisor and mandibular molar share a similar signaling control of Fgf-8, Pitx-2, Shh, Msx-1, Pax-9 and Bmp-4 genes at the stage of oral epithelial thickening to the early bud stage of tooth development.

Adding Theoretical Grounding to Grounded Theory: Toward Multi-Grounded Theory

OpenAIRE

Göran Goldkuhl; Stefan Cronholm

2010-01-01

The purpose of this paper is to challenge some of the cornerstones of the grounded theory approach and propose an extended and alternative approach for data analysis and theory development, which the authors call multi-grounded theory (MGT). A multi-grounded theory is not only empirically grounded; it is also grounded in other ways. Three different grounding processes are acknowledged: theoretical, empirical, and internal grounding. The authors go beyond the pure inductivist approach in GT an...

Marshall Space Flight Center Ground Systems Development and Integration

Science.gov (United States)

Wade, Gina

2016-01-01

Ground Systems Development and Integration performs a variety of tasks in support of the Mission Operations Laboratory (MOL) and other Center and Agency projects. These tasks include various systems engineering processes such as performing system requirements development, system architecture design, integration, verification and validation, software development, and sustaining engineering of mission operations systems that has evolved the Huntsville Operations Support Center (HOSC) into a leader in remote operations for current and future NASA space projects. The group is also responsible for developing and managing telemetry and command configuration and calibration databases. Personnel are responsible for maintaining and enhancing their disciplinary skills in the areas of project management, software engineering, software development, software process improvement, telecommunications, networking, and systems management. Domain expertise in the ground systems area is also maintained and includes detailed proficiency in the areas of real-time telemetry systems, command systems, voice, video, data networks, and mission planning systems.

Memory for conversation and the development of common ground.

Science.gov (United States)

McKinley, Geoffrey L; Brown-Schmidt, Sarah; Benjamin, Aaron S

2017-11-01

Efficient conversation is guided by the mutual knowledge, or common ground, that interlocutors form as a conversation progresses. Characterized from the perspective of commonly used measures of memory, efficient conversation should be closely associated with item memory-what was said-and context memory-who said what to whom. However, few studies have explicitly probed memory to evaluate what type of information is maintained following a communicative exchange. The current study examined how item and context memory relate to the development of common ground over the course of a conversation, and how these forms of memory vary as a function of one's role in a conversation as speaker or listener. The process of developing common ground was positively related to both item and context memory. In addition, content that was spoken was remembered better than content that was heard. Our findings illustrate how memory assessments can complement language measures by revealing the impact that basic conversational processes have on memory for what has been discussed. By taking this approach, we show that not only does the process of forming common ground facilitate communication in the present, but it also promotes an enduring record of that event, facilitating conversation into the future.

Validating a Measure of Stages of Change in Career Development

Science.gov (United States)

Hammond, Marie S.; Michael, Tony; Luke, Charles

2017-01-01

Research on the processes of change in career development has focused on developmental stages rather than processes. This manuscript reports on the development and validation of the stages of change-career development scale, adapted from McConnaughy, Prochaska, & Velicer (1983) measure of stages of change in psychotherapy. Data from 875…

Radiologic Predictors for Clinical Stage IA Lung Adenocarcinoma with Ground Glass Components: A Multi-Center Study of Long-Term Outcomes.

Directory of Open Access Journals (Sweden)

Zhao Li

Full Text Available This study was to define preoperative predictors from radiologic findings for the pathologic risk groups based on long-term surgical outcomes, in the aim to help guide individualized patient management.We retrospectively reviewed 321 consecutive patients with clinical stage IA lung adenocarcinoma with ground glass component on computed tomography (CT scanning. Pathologic diagnosis for resection specimens was based on the 2011 IASLC/ATS/ERS classification of lung adenocarcinoma. Patients were classified into different pathologic risk grading groups based on their lymph node status, local regional recurrence and overall survival. Radiologic characteristics of the pulmonary nodules were re-evaluated by reconstructed three-dimension CT (3D-CT. Univariate and multivariate analysis identifies independent radiologic predictors from tumor diameter, total volume (TV, average CT value (AVG, and solid-to-tumor (S/T ratio. Receiver operating characteristic curves (ROC studies were carried out to determine the cutoff value(s for the predictor(s. Univariate cox regression model was used to determine the clinical significance of the above findings.A total of 321 patients with clinical stage IA lung adenocarcinoma with ground glass components were included in our study. Patients were classified into two pathologic low- and high- risk groups based on their distinguished surgical outcomes. A total of 134 patients fell into the low-risk group. Univariate and multivariate analyses identified AVG (HR: 32.210, 95% CI: 3.020-79.689, P<0.001 and S/T ratio (HR: 12.212, 95% CI: 5.441-27.408, P<0.001 as independent predictors for pathologic risk grading. ROC curves studies suggested the optimal cut-off values for AVG and S/T ratio were-198 (area under the curve [AUC] 0.921, 2.9 (AUC 0.996 and 54% (AUC 0.907, respectively. The tumor diameter and TV were excluded for the low AUCs (0.778 and 0.767. Both the cutoff values of AVG and S/T ratio were correlated with pathologic

Contemporary sand wedge development in seasonally frozen ground and paleoenvironmental implications

Science.gov (United States)

Wolfe, Stephen A.; Morse, Peter D.; Neudorf, Christina M.; Kokelj, Steven V.; Lian, Olav B.; O'Neill, H. Brendan

2018-05-01

Contemporary sand wedges and sand veins are active in seasonally frozen ground within the extensive discontinuous permafrost zone in Northwest Territories, Canada. The region has a subarctic continental climate with 291 mm a-1 precipitation, -4.1 °C mean annual air temperature, warm summers (July mean 17.0 °C), and cold winters (January mean -26.6 °C). Five years of continuous observations indicate that interannual variation of the ground thermal regime is dominantly controlled by winter air temperature and snow cover conditions. At sandy sites, thin snow cover and high thermal conductivity promote rapid freezing, high rates of ground cooling, and low near-surface ground temperatures (-15 to -25 °C), resulting in thermal contraction cracking to depths of 1.2 m. Cracking potentials are high in sandy soils when air temperatures are air temperatures are ≤-17 °C, and snow cover is conditions in peatlands maintain permafrost, but thermal contraction cracking does not occur because thicker snow cover and the thermal properties of peat prolong freezeback and maintain higher winter ground temperatures. A combination of radiocarbon dating, optical dating, and stratigraphic observations were used to differentiate sand wedge types and formation histories. Thermal contraction cracks that develop in the sandy terrain are filled by surface (allochthonous) and/or host (autochthonous) material during the thaw season. Epigenetic sand wedges infilled with allochthonous sand develop within former beach sediments beneath an active eolian sand sheet. Narrower and deeper syngenetic wedges developed within aggrading eolian sand sheets, whereas wider and shallower antisyngenetic wedges developed in areas of active erosion. Thermal contraction cracking beneath vegetation-stabilized surfaces leads to crack infilling by autochthonous host and overlying organic material, with resultant downturning and subsidence of adjacent strata. Sand wedge development in seasonally frozen ground

The Development of the TPR-DB as Grounded Theory Method

DEFF Research Database (Denmark)

Carl, Michael; Schaeffer, Moritz

2018-01-01

and refine the emerging concepts and categories and to validate the developing theories, the TPR-DB has been extended with further translation studies in different languages and translation modes. In this respect, it shares many features with Grounded Theory Method. This method was discovered in 1967...... and used in qualitative research in social science ad many other research areas. We analyze the TPR-DB development as a Grounded Theory Method....... on quantitative assessment of well-defined research questions on cognitive processes in human translation production, the integration of the data into the TPR-DB allowed for broader qualitative and exploratory research which has led to new codes, categories and research themes. In a constant effort to develop...

Development of Stepped-Frequency Ground-Penetrating Radar

DEFF Research Database (Denmark)

Jakobsen, Kaj Bjarne

1998-01-01

The status of the development of a multi-monostatic stepped-frequency ground-penetrating radar (GPR) at The Department of Applied Electronics (IAE), The Technical University of Denmark (DTU) is presented. The feasibility of the used approach is demonstrated by the successful detection of small me...... metallic and non-metallic objects with a diameter of 54 mm buried in loamy soil....

Methodological Grounds of Managing Innovation Development of Restaurants

OpenAIRE

Naidiuk V. S.

2013-01-01

The goal of the article lies in identification and further development of methodological grounds of managing the innovation development of restaurants. Based on the data of the critical analysis of existing scientific views on interpretation of the essence of the "managing innovation development of an enterprise" notion, the article conducts clarification of this definition. In the result of the study the article builds up a cause-effect diagram of solution of the problem of ensuring efficien...

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite.

Directory of Open Access Journals (Sweden)

Upeksha L Rathnapala

2017-06-01

Full Text Available The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty means that malaria remains a major global health crisis. Understanding metabolic pathways at all parasite life stages is important in prioritising and targeting novel anti-parasitic compounds. The unusual heme synthesis pathway of the rodent malaria parasite, Plasmodium berghei, requires eight enzymes distributed across the mitochondrion, apicoplast and cytoplasm. Deletion of the ferrochelatase (FC gene, the final enzyme in the pathway, confirms that heme synthesis is not essential in the red blood cell stages of the life cycle but is required to complete oocyst development in mosquitoes. The lethality of FC deletions in the mosquito stage makes it difficult to study the impact of these mutations in the subsequent liver stage. To overcome this, we combined locus-specific fluorophore expression with a genetic complementation approach to generate viable, heterozygous oocysts able to produce a mix of FC expressing and FC deficient sporozoites. These sporozoites show normal motility and can invade liver cells, where FC deficient parasites can be distinguished by fluorescence and phenotyped. Parasites lacking FC exhibit a severe growth defect within liver cells, with development failure detectable in the early to mid stages of liver development in vitro. FC deficient parasites could not complete liver stage development in vitro nor infect naïve mice, confirming liver stage arrest. These results validate the heme pathway as a potential target for prophylactic drugs targeting liver stage parasites. In addition, we demonstrate that our simple genetic approach can extend the phenotyping window beyond the insect stages, opening considerable scope for straightforward reverse genetic analysis of genes that are dispensable in blood stages but essential for completing mosquito development.

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite.

Science.gov (United States)

Rathnapala, Upeksha L; Goodman, Christopher D; McFadden, Geoffrey I

2017-06-01

The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty means that malaria remains a major global health crisis. Understanding metabolic pathways at all parasite life stages is important in prioritising and targeting novel anti-parasitic compounds. The unusual heme synthesis pathway of the rodent malaria parasite, Plasmodium berghei, requires eight enzymes distributed across the mitochondrion, apicoplast and cytoplasm. Deletion of the ferrochelatase (FC) gene, the final enzyme in the pathway, confirms that heme synthesis is not essential in the red blood cell stages of the life cycle but is required to complete oocyst development in mosquitoes. The lethality of FC deletions in the mosquito stage makes it difficult to study the impact of these mutations in the subsequent liver stage. To overcome this, we combined locus-specific fluorophore expression with a genetic complementation approach to generate viable, heterozygous oocysts able to produce a mix of FC expressing and FC deficient sporozoites. These sporozoites show normal motility and can invade liver cells, where FC deficient parasites can be distinguished by fluorescence and phenotyped. Parasites lacking FC exhibit a severe growth defect within liver cells, with development failure detectable in the early to mid stages of liver development in vitro. FC deficient parasites could not complete liver stage development in vitro nor infect naïve mice, confirming liver stage arrest. These results validate the heme pathway as a potential target for prophylactic drugs targeting liver stage parasites. In addition, we demonstrate that our simple genetic approach can extend the phenotyping window beyond the insect stages, opening considerable scope for straightforward reverse genetic analysis of genes that are dispensable in blood stages but essential for completing mosquito development.

Solar Constant (SOLCON) Experiment: Ground Support Equipment (GSE) software development

Science.gov (United States)

Gibson, M. Alan; Thomas, Susan; Wilson, Robert

1991-01-01

The Solar Constant (SOLCON) Experiment, the objective of which is to determine the solar constant value and its variability, is scheduled for launch as part of the Space Shuttle/Atmospheric Laboratory for Application and Science (ATLAS) spacelab mission. The Ground Support Equipment (GSE) software was developed to monitor and analyze the SOLCON telemetry data during flight and to test the instrument on the ground. The design and development of the GSE software are discussed. The SOLCON instrument was tested during Davos International Solar Intercomparison, 1989 and the SOLCON data collected during the tests are analyzed to study the behavior of the instrument.

Simple-1: Development stage of the data transmission system for a solid propellant mid-power rocket model

Science.gov (United States)

Yarce, Andrés; Sebastián Rodríguez, Juan; Galvez, Julián; Gómez, Alejandro; García, Manuel J.

2017-06-01

This paper presents the development stage of a communication module for a solid propellant mid-power rocket model. The communication module was named. Simple-1 and this work considers its design, construction and testing. A rocket model Estes Ventris Series Pro II® was modified to introduce, on the top of the payload, several sensors in a CanSat form factor. The Printed Circuit Board (PCB) was designed and fabricated from Commercial Off The Shelf (COTS) components and assembled in a cylindrical rack structure similar to this small format satellite concept. The sensors data was processed using one Arduino Mini and transmitted using a radio module to a Software Defined Radio (SDR) HackRF based platform on the ground station. The Simple-1 was tested using a drone in successive releases, reaching altitudes from 200 to 300 meters. Different kind of data, in terms of altitude, position, atmospheric pressure and vehicle temperature were successfully measured, making possible the progress to a next stage of launching and analysis.

[Review of digital ground object spectral library].

Science.gov (United States)

Zhou, Xiao-Hu; Zhou, Ding-Wu

2009-06-01

A higher spectral resolution is the main direction of developing remote sensing technology, and it is quite important to set up the digital ground object reflectance spectral database library, one of fundamental research fields in remote sensing application. Remote sensing application has been increasingly relying on ground object spectral characteristics, and quantitative analysis has been developed to a new stage. The present article summarized and systematically introduced the research status quo and development trend of digital ground object reflectance spectral libraries at home and in the world in recent years. Introducing the spectral libraries has been established, including desertification spectral database library, plants spectral database library, geological spectral database library, soil spectral database library, minerals spectral database library, cloud spectral database library, snow spectral database library, the atmosphere spectral database library, rocks spectral database library, water spectral database library, meteorites spectral database library, moon rock spectral database library, and man-made materials spectral database library, mixture spectral database library, volatile compounds spectral database library, and liquids spectral database library. In the process of establishing spectral database libraries, there have been some problems, such as the lack of uniform national spectral database standard and uniform standards for the ground object features as well as the comparability between different databases. In addition, data sharing mechanism can not be carried out, etc. This article also put forward some suggestions on those problems.

Constellation Program Electrical Ground Support Equipment Research and Development

Science.gov (United States)

McCoy, Keegan S.

2010-01-01

At the Kennedy Space Center, I engaged in the research and development of electrical ground support equipment for NASA's Constellation Program. Timing characteristics playa crucial role in ground support communications. Latency and jitter are two problems that must be understood so that communications are timely and consistent within the Kennedy Ground Control System (KGCS). I conducted latency and jitter tests using Alien-Bradley programmable logic controllers (PLCs) so that these two intrinsic network properties can be reduced. Time stamping and clock synchronization also play significant roles in launch processing and operations. Using RSLogix 5000 project files and Wireshark network protocol analyzing software, I verified master/slave PLC Ethernet module clock synchronization, master/slave IEEE 1588 communications, and time stamping capabilities. All of the timing and synchronization test results are useful in assessing the current KGCS operational level and determining improvements for the future.

Physics Identity Development: A Snapshot of the Stages of Development of Upper-Level Physics Students

Science.gov (United States)

Irving, Paul W.; Sayre, Eleanor C.

2013-01-01

As part of a longitudinal study into identity development in upper-level physics students a phenomenographic research method is employed to assess the stages of identity development of a group of upper-level students. Three categories of description were discovered which indicate the three different stages of identity development for this group…

Stages of Teachers' Careers: Implications for Professional Development.

Science.gov (United States)

Christensen, Judith; And Others

This monograph on the development of teachers' careers synthesizes researchers' prescriptions for early-, mid-, and late-career professional development; and describes successful programs that demonstrate sensitivity to the stages of teachers' growth. The first chapter, "Teachers' Career Development," reviews current adult- and career-stage…

Affordable Development and Demonstration of a Small NTR Engine and Stage: A Preliminary NASA, DOE, and Industry Assessment

Science.gov (United States)

Borowski, Stanley K.; Sefcik, Robert J.; Fittje, James E.; McCurdy, David R.; Qualls, Arthur L.; Schnitzler, Bruce G.; Werner, James E.; Weitzberg, Abraham; Joyner, Claude R.

2015-01-01

maximizing the use of existing and flight proven liquid rocket and stage hardware (e.g., from the RL10-B2 engine and Delta Cryogenic Second Stage) to further ensure affordability. This paper provides a preliminary NASA, DOE and industry assessment of what is required - the key DDT&E activities, development options, and the associated schedule - to affordably build, ground test and fly a small NTR engine and stage within a 10-year timeframe.

Preliminary development of a wing in ground effect vehicle

Science.gov (United States)

Abidin, Razali; Ahamat, Mohamad Asmidzam; Ahmad, Tarmizi; Saad, Mohd Rasdan; Hafizi, Ezzat

2018-02-01

Wing in ground vehicle is one of the mode of transportation that allows high speed movement over water by travelling few meters above the water level. Through this manouver strategy, a cushion of compressed air exists between the wing in ground vehicle wings and water. This significantly increase the lift force, thus reducing the necessity in having a long wing span. Our project deals with the development of wing in ground vehicle with the capability of transporting four people. The total weight of this wing in ground vehicle was estimated at 5.4 kN to enable the prediction on required wing area, minimum takeoff velocity, drag force and engine power requirement. The required takeoff velocity is decreases as the lift coefficient increases, and our current mathematical model shows the takeoff velocity at 50 m/s avoid the significant increase in lift coefficient for the wing area of 5 m2. At the velocity of 50 m/s, the drag force created by this wing in ground vehicle is well below 1 kN, which required a 100-120 kW of engine power if the propeller has the efficiency of 0.7. Assessment on the stresses and deflection of the hull structural indicate the capability of plywood to withstand the expected load. However, excessive deflection was expected in the rear section which requires a minor structural modification. In the near future, we expect that the wind tunnel tests of this wing in ground vehicle model would enable more definite prediction on the important parameters related to its performance.

Stages of socio-economic development: Shah Wali-Allah's concept of al-irtifaqat

OpenAIRE

aislahi, Abdul Azim

1989-01-01

The present paper introduces Shah Wali-Allah Dehlawi’s concept of the stages of socio-economic developments (al-irtifaqat). According to him, starting from simple primitive village life to an international community, the socio-economic development of human society can be divided into four stages. The first stage is dominated by simple economic struggle while the last stage is developed to maintain just political order on international level, to safeguard the socio-economic interests of differ...

High Throughput Determination of Plant Height, Ground Cover, and Above-Ground Biomass in Wheat with LiDAR.

Science.gov (United States)

Jimenez-Berni, Jose A; Deery, David M; Rozas-Larraondo, Pablo; Condon, Anthony Tony G; Rebetzke, Greg J; James, Richard A; Bovill, William D; Furbank, Robert T; Sirault, Xavier R R

2018-01-01

Crop improvement efforts are targeting increased above-ground biomass and radiation-use efficiency as drivers for greater yield. Early ground cover and canopy height contribute to biomass production, but manual measurements of these traits, and in particular above-ground biomass, are slow and labor-intensive, more so when made at multiple developmental stages. These constraints limit the ability to capture these data in a temporal fashion, hampering insights that could be gained from multi-dimensional data. Here we demonstrate the capacity of Light Detection and Ranging (LiDAR), mounted on a lightweight, mobile, ground-based platform, for rapid multi-temporal and non-destructive estimation of canopy height, ground cover and above-ground biomass. Field validation of LiDAR measurements is presented. For canopy height, strong relationships with LiDAR ( r 2 of 0.99 and root mean square error of 0.017 m) were obtained. Ground cover was estimated from LiDAR using two methodologies: red reflectance image and canopy height. In contrast to NDVI, LiDAR was not affected by saturation at high ground cover, and the comparison of both LiDAR methodologies showed strong association ( r 2 = 0.92 and slope = 1.02) at ground cover above 0.8. For above-ground biomass, a dedicated field experiment was performed with destructive biomass sampled eight times across different developmental stages. Two methodologies are presented for the estimation of biomass from LiDAR: 3D voxel index (3DVI) and 3D profile index (3DPI). The parameters involved in the calculation of 3DVI and 3DPI were optimized for each sample event from tillering to maturity, as well as generalized for any developmental stage. Individual sample point predictions were strong while predictions across all eight sample events, provided the strongest association with biomass ( r 2 = 0.93 and r 2 = 0.92) for 3DPI and 3DVI, respectively. Given these results, we believe that application of this system will provide new

Collaboration with Pharma Will Introduce Nanotechnologies in Early Stage Drug Development | FNLCR Staging

Science.gov (United States)

The Frederick National Lab has begun to assist several major pharmaceutical companies in adopting nanotechnologies in early stage drug development, when the approach is most efficient and cost-effective. For some time, the national lab’s Nanotechno

On development and improvement of evaluation techniques for strong ground motion

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-08-15

Issues regarding evaluation of active fault and ground motion for formulation of design basis ground motion (Ss) were identified during NISA and NSC seismic safety reviewing activities, which have been conducted in the light of the revision of the relevant seismic regulatory guide in 2006 and the experiences of the Niigataken Chuetsu-oki Earthquake in 2007 and the 2011 off the Pacific Coast of Tohoku Earthquake. In this theme following four subjects were investigated to resolve the important problems for ground motion evaluation, (1) advanced evaluation of ground motion using fault model and uncertainty; (2) improving evaluation of ground motion using attenuation relation of response spectrum; (3) development of advanced technique for ground motion observation and observation tool in deep borehole; (4) improving the evaluation of site effect and seismic wave propagation characteristics. Obtained results will be incorporated into the national safety review and also in the safety standard guidelines of the International Atomic Energy Agency (IAEA) using its Extra-Budgetary Program (IAEA EBP), thereby contributing to technical cooperation in global nuclear seismic safety. (author)

Stage line diagram: an age-conditional reference diagram for tracking development.

Science.gov (United States)

van Buuren, Stef; Ooms, Jeroen C L

2009-05-15

This paper presents a method for calculating stage line diagrams, a novel type of reference diagram useful for tracking developmental processes over time. Potential fields of applications include: dentistry (tooth eruption), oncology (tumor grading, cancer staging), virology (HIV infection and disease staging), psychology (stages of cognitive development), human development (pubertal stages) and chronic diseases (stages of dementia). Transition probabilities between successive stages are modeled as smoothly varying functions of age. Age-conditional references are calculated from the modeled probabilities by the mid-P value. It is possible to eliminate the influence of age by calculating standard deviation scores (SDS). The method is applied to the empirical data to produce reference charts on secondary sexual maturation. The mean of the empirical SDS in the reference population is close to zero, whereas the variance depends on age. The stage line diagram provides quick insight into both status (in SDS) and tempo (in SDS/year) of development of an individual child. Other measures (e.g. height SDS, body mass index SDS) from the same child can be added to the chart. Diagrams for sexual maturation are available as a web application at http://vps.stefvanbuuren.nl/puberty. The stage line diagram expresses status and tempo of discrete changes on a continuous scale. Wider application of these measures scores opens up new analytic possibilities. (c) 2009 John Wiley & Sons, Ltd.

Changes in psychosocial well-being during stages of gay identity development.

Science.gov (United States)

Halpin, Sean A; Allen, Michael W

2004-01-01

The current study evaluated the stage theory of Homosexual Identity Formation (HIF) developed by Cass (1979), in terms of the relationship between stage of gay identity development and psychosocial well-being. Four hundred twenty-five males (12 to 64 years, M = 29.2) reporting sexual attraction to other men provided demographic information and completed psychosocial measures: the Happiness-Sadness Scale (McGreal & Joseph, 1993), the Satisfaction with Life Scale (Diener, Emmons, Larsen & Griffin, 1985), the UCLA Loneliness Scale (Russell, Peplau & Ferguson, 1978), the Index of Self-Esteem (Hudson, 1982), and the Gay Identity Questionnaire (Brady & Busse, 1994). Correlation analysis and ANCOVAs controlling for age and nationality demonstrated that the 6 sequential stages of HIF were associated with a U-shaped function for the psychosocial variables. Well-being was high during the initial Confusion and Comparison stages of HIF, was reduced during the middle Tolerance and Acceptance stages, and was again high in the later Pride and Synthesis stages. Each of the psychosocial variables was significantly different according to stage of development (p <.001). Qualitative analysis of subjects' comments also revealed support for the U-shaped pattern.

Two critical periods in early visual cortex during figure–ground segregation

Science.gov (United States)

Wokke, Martijn E; Sligte, Ilja G; Steven Scholte, H; Lamme, Victor A F

2012-01-01

The ability to distinguish a figure from its background is crucial for visual perception. To date, it remains unresolved where and how in the visual system different stages of figure–ground segregation emerge. Neural correlates of figure border detection have consistently been found in early visual cortex (V1/V2). However, areas V1/V2 have also been frequently associated with later stages of figure–ground segregation (such as border ownership or surface segregation). To causally link activity in early visual cortex to different stages of figure–ground segregation, we briefly disrupted activity in areas V1/V2 at various moments in time using transcranial magnetic stimulation (TMS). Prior to stimulation we presented stimuli that made it possible to differentiate between figure border detection and surface segregation. We concurrently recorded electroencephalographic (EEG) signals to examine how neural correlates of figure–ground segregation were affected by TMS. Results show that disruption of V1/V2 in an early time window (96–119 msec) affected detection of figure stimuli and affected neural correlates of figure border detection, border ownership, and surface segregation. TMS applied in a relatively late time window (236–259 msec) selectively deteriorated performance associated with surface segregation. We conclude that areas V1/V2 are not only essential in an early stage of figure–ground segregation when figure borders are detected, but subsequently causally contribute to more sophisticated stages of figure–ground segregation such as surface segregation. PMID:23170239

Two critical periods in early visual cortex during figure-ground segregation.

Science.gov (United States)

Wokke, Martijn E; Sligte, Ilja G; Steven Scholte, H; Lamme, Victor A F

2012-11-01

The ability to distinguish a figure from its background is crucial for visual perception. To date, it remains unresolved where and how in the visual system different stages of figure-ground segregation emerge. Neural correlates of figure border detection have consistently been found in early visual cortex (V1/V2). However, areas V1/V2 have also been frequently associated with later stages of figure-ground segregation (such as border ownership or surface segregation). To causally link activity in early visual cortex to different stages of figure-ground segregation, we briefly disrupted activity in areas V1/V2 at various moments in time using transcranial magnetic stimulation (TMS). Prior to stimulation we presented stimuli that made it possible to differentiate between figure border detection and surface segregation. We concurrently recorded electroencephalographic (EEG) signals to examine how neural correlates of figure-ground segregation were affected by TMS. Results show that disruption of V1/V2 in an early time window (96-119 msec) affected detection of figure stimuli and affected neural correlates of figure border detection, border ownership, and surface segregation. TMS applied in a relatively late time window (236-259 msec) selectively deteriorated performance associated with surface segregation. We conclude that areas V1/V2 are not only essential in an early stage of figure-ground segregation when figure borders are detected, but subsequently causally contribute to more sophisticated stages of figure-ground segregation such as surface segregation.

How to Develop a Multi-Grounded Theory: the evolution of a business process theory

Directory of Open Access Journals (Sweden)

Mikael Lind

2006-05-01

Full Text Available In the information systems field there is a great need for different theories. Theory development can be performed in different ways – deductively and/or inductively. Different approaches with their pros and cons for theory development exists. A combined approach, which builds on inductive as well as deductive thinking, has been put forward – a Multi-Grounded Theory approach. In this paper the evolution of a business process theory is regarded as the development of a multi-grounded theory. This evolution is based on empirical studies, theory-informed conceptual development and the creation of conceptual cohesion. The theoretical development has involved a dialectic approach aiming at a theoretical synthesis based on antagonistic theories. The result of this research process was a multi-grounded business process theory. Multi-grounded means that the theory is empirically, internally and theoretically founded. This business process theory can be used as an aid for business modellers to direct attention towards relevant aspects when business process determination is performed.

On development and improvement of evaluation techniques for strong ground motion

International Nuclear Information System (INIS)

Tsutsumi, Hideaki; Wu, Changjiang; Kobayashi, Genyu; Mamada, Yutaka

2011-01-01

The NSC regulatory guide for reviewing seismic design, revised in September 2006 requires revision of evaluation method for design seismic ground motion. The new design seismic ground motion must be evaluated based on not only response spectra method but also fault model method. In the case of evaluation method using fault model, factors which affect ground motion (heterogeneous fault rupture, frequency dependence of radiation pattern on seismic waves and high-frequency reduction on observed spectrum (fmax)) were studied in order to apply the models to actual phenomenon. In the case of response spectra, attenuation relationships for earthquake response spectra on seismic basement, considering the earthquake source types (e.g. inter-plate, intra-plate and crustal types), were developed. In addition, in coping with the problems on evaluating ground motion amplification and attenuation in deep underground, JNES drills 3000 m deep boring and acquires the data for verification of new evaluation methods at deep borehole locating on sedimentary rock site in the Niigata Institute of Technology. Moreover JNES develops borehole seismometer enduring high temperature and high pressure and enabling multi-depth seismic observation system to perform vertical seismic array observation. (author)

Grounded Learning Experience: Helping Students Learn Physics through Visuo-Haptic Priming and Instruction

Science.gov (United States)

Huang, Shih-Chieh Douglas

2013-01-01

In this dissertation, I investigate the effects of a grounded learning experience on college students' mental models of physics systems. The grounded learning experience consisted of a priming stage and an instruction stage, and within each stage, one of two different types of visuo-haptic representation was applied: visuo-gestural simulation…

A Proven Methodology for Developing Secure Software and Applying It to Ground Systems

Science.gov (United States)

Bailey, Brandon

2016-01-01

Part Two expands upon Part One in an attempt to translate the methodology for ground system personnel. The goal is to build upon the methodology presented in Part One by showing examples and details on how to implement the methodology. Section 1: Ground Systems Overview; Section 2: Secure Software Development; Section 3: Defense in Depth for Ground Systems; Section 4: What Now?

Thermal Performance Analyses of Multiborehole Ground Heat Exchangers

Directory of Open Access Journals (Sweden)

Wanjing Luo

2017-01-01

Full Text Available Geothermal energy known as a clean, renewable energy resource is widely available and reliable. Ground heat exchangers (GHEs can assist the development of geothermal energy by reducing the capital cost and greenhouse gas emission. In this paper, a novel semianalytical method was developed to study the thermal performance of multiborehole ground heat exchangers (GHEs with arbitrary configurations. By assuming a uniform inlet fluid temperature (UIFT, instead of uniform heat flux (UHF, the effects of thermal interference and the thermal performance difference between different boreholes can be examined. Simulation results indicate that the monthly average outlet fluid temperatures of GHEs will increase gradually while the annual cooling load of the GHEs is greater than the annual heating load. Besides, two mechanisms, the thermal dissipation and the heat storage effect, will determine the heat transfer underground, which can be further divided into four stages. Moreover, some boreholes will be malfunctioned; that is, boreholes can absorb heat from ground when the GHEs are under the cooling mode. However, as indicated by further investigations, this malfunction can be avoided by increasing borehole spacing.

Ground-water development and problems in Idaho

Science.gov (United States)

Crosthwaite, E.G.

1954-01-01

The development of groundwater for irrigation in Idaho, as most of you know, has proceeded at phenomenal rate since the Second World War. In the period 1907 to 1944 inclusive only about 328 valid permits and licenses to appropriate ground water were issued by the state. thereafter 28 permits became valid in 1945, 83 in 1946, and 121 in 1947. Sine 1947 permits and licenses have been issued at the rate of more than 400 a year.  

THE STAGES OF ESTABLISHMENT AND DEVELOPMENT OF FINANCIAL MANAGEMENT

Directory of Open Access Journals (Sweden)

Roman GRESHKO

2017-06-01

Full Text Available The paper reviews major stages of establishment and development of financial management, main conceptual theories, and methods, approaches, developed by academic economists in the field of corporate finance that became the basis for the development of financial management as a science. In the paper, the authors identify the major five stages of its establishment, in the process of which the range of thoroughly studied issues was constantly expanded, the methodologies of their research were enriched. The paper describes the main scientific works of famous economists of the relevant periods that have made a significant contribution to the formation and development of financial management as a science. The authors drew the conclusions about prerequisites to the development of financial science and research priorities in the financial management of enterprises.

A Mixed Prediction Model of Ground Subsidence for Civil Infrastructures on Soft Ground

Directory of Open Access Journals (Sweden)

Kiyoshi Kobayashi

2012-01-01

Full Text Available The estimation of ground subsidence processes is an important subject for the asset management of civil infrastructures on soft ground, such as airport facilities. In the planning and design stage, there exist many uncertainties in geotechnical conditions, and it is impossible to estimate the ground subsidence process by deterministic methods. In this paper, the sets of sample paths designating ground subsidence processes are generated by use of a one-dimensional consolidation model incorporating inhomogeneous ground subsidence. Given the sample paths, the mixed subsidence model is presented to describe the probabilistic structure behind the sample paths. The mixed model can be updated by the Bayesian methods based upon the newly obtained monitoring data. Concretely speaking, in order to estimate the updating models, Markov Chain Monte Calro method, which is the frontier technique in Bayesian statistics, is applied. Through a case study, this paper discussed the applicability of the proposed method and illustrated its possible application and future works.

Analysing growth and development of plants jointly using developmental growth stages.

Science.gov (United States)

Dambreville, Anaëlle; Lauri, Pierre-Éric; Normand, Frédéric; Guédon, Yann

2015-01-01

Plant growth, the increase of organ dimensions over time, and development, the change in plant structure, are often studied as two separate processes. However, there is structural and functional evidence that these two processes are strongly related. The aim of this study was to investigate the co-ordination between growth and development using mango trees, which have well-defined developmental stages. Developmental stages, determined in an expert way, and organ sizes, determined from objective measurements, were collected during the vegetative growth and flowering phases of two cultivars of mango, Mangifera indica. For a given cultivar and growth unit type (either vegetative or flowering), a multistage model based on absolute growth rate sequences deduced from the measurements was first built, and then growth stages deduced from the model were compared with developmental stages. Strong matches were obtained between growth stages and developmental stages, leading to a consistent definition of integrative developmental growth stages. The growth stages highlighted growth asynchronisms between two topologically connected organs, namely the vegetative axis and its leaves. Integrative developmental growth stages emphasize that developmental stages are closely related to organ growth rates. The results are discussed in terms of the possible physiological processes underlying these stages, including plant hydraulics, biomechanics and carbohydrate partitioning. © The Author 2014. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Nuclear Cryogenic Propulsion Stage Affordable Development Strategy

Science.gov (United States)

Doughty, Glen E.; Gerrish, H. P.; Kenny, R. J.

2014-01-01

The development of nuclear power for space use in nuclear thermal propulsion (NTP) systems will involve significant expenditures of funds and require major technology development efforts. The development effort must be economically viable yet sufficient to validate the systems designed. Efforts are underway within the National Aeronautics and Space Administration's (NASA) Nuclear Cryogenic Propulsion Stage Project (NCPS) to study what a viable program would entail. The study will produce an integrated schedule, cost estimate and technology development plan. This will include the evaluation of various options for test facilities, types of testing and use of the engine, components, and technology developed. A "Human Rating" approach will also be developed and factored into the schedule, budget and technology development approach.

Classical and post-classical stages of development of ideas on global conflicts

Directory of Open Access Journals (Sweden)

Y. S. Pilipenko

2016-06-01

Thus, in the history of the development of ideas about the nature of the conflict, it is possible to allocate three stages. The first stage is a classic, it representatives of which are O. Conte, K. Marx, G. Zimmel. The second stage is post-classical, represented by such scholars as P. Sztompka, G. lutsishin, N. Luhmann, M. Zelenkov, V. Zavalniuk. The third stage is multi-paradigmal, not formed yet, but actively developed by modern sociologists as I. Bekeshkina, Ye. Golovakha, A. Ruchka and other.

Monitoring the hydrologic system for potential effects of geothermal and ground-water development in the Long Valley Caldera, Mono County, California, USA

International Nuclear Information System (INIS)

Farrar, C.D.; Lyster, D.L.

1990-01-01

In the early 1980's, renewed interest in the geothermal potential of the Long valley caldera, California, highlighted the need to balance the benefits of energy development with the established recreational activities of the area. The Long Valley Hydrologic Advisory Committee, formed in 1987, instituted a monitoring program to collect data during the early stages of resource utilization to evaluate potential effects on the hydrologic system. This paper reports that early data show declines in streamflow, spring flow, and ground-water levels caused by 6 years of below-average precipitation. Springs in the Hot Creek State Fish Hatchery area discharge water that is a mixture of nonthermal and hydrothermal components. Possible sources of nonthermal water have been identified by comparing deuterium concentrations in streams and springs. The equivalent amount of undiluted thermal water discharged from the springs was calculated on the basis of boron and chloride concentrations. Quantifying the thermal and nonthermal fractions of the total flow may allow researchers to assess changes in flow volume or temperature of the springs caused by ground-water or geothermal development

Ground Pollution Science

International Nuclear Information System (INIS)

Oh, Jong Min; Bae, Jae Geun

1997-08-01

This book deals with ground pollution science and soil science, classification of soil and fundamentals, ground pollution and human, ground pollution and organic matter, ground pollution and city environment, environmental problems of the earth and ground pollution, soil pollution and development of geological features of the ground, ground pollution and landfill of waste, case of measurement of ground pollution.

Grounding the Innovation of Future Technologies

Directory of Open Access Journals (Sweden)

Antti Oulasvirta

2005-01-01

Full Text Available Mobile and ubiquitous technologies can potentially change the role of information and communication technology in human lives. Empirical, human-centered approaches are emerging as an alternative to technology-driven approaches in the innovation of these technologies. Three necessary empirical stages, intertwined with analytical ones and with each informing and grounding the succeeding stages, are analyzed. First, needfinding is utilized to discover societal and individual demands for technology. Second, observational and experimental studies examine the social and cognitive preconditions for interaction. From these two steps, a hypothesis is formulated regarding how technology will change existing practices. Finally, this hypothesis, embodied in the design of a prototype, is tested in a field trial. Four design cases illustrate the value of empirical grounding.

Space nuclear power plant technology development philosophy for a ground engineering phase

International Nuclear Information System (INIS)

Buden, D.; Trapp, T.J.; Los Alamos National Lab., NM)

1985-01-01

The development of a space qualified nuclear power plant is proceeding from the technical assessment and advancement phase to the ground engineering phase. In this new phase, the selected concept will be matured by the completion of activities needed before protoflight units can be assembled and qualified for first flight applications. This paper addresses a possible philosophy to arrive at the activities to be performed during the ground engineering phase. The philosophy is derived from what we believe a potential user of nuclear power would like to see completed before commitment to a flight development phase. 5 references

Space nuclear power plant technology development philosophy for a ground engineering phase

International Nuclear Information System (INIS)

Buden, D.; Trapp, T.J.

1985-01-01

The development of a space qualified nuclear power plant is proceeding from the Technical Assessment and Advancement Phase to the Ground Engineering Phase. In this new phase, the selected concept will be matured by the completion of activities needed before protoflight units can be assembled and qualified for first flight applications. This paper addresses a possible philosophy to arrive at the activities to be performed during the Ground Engineering Phase. The philosophy is derived from what we believe a potential user of nuclear power would like to see completed before commitment to a flight development phase

Development of Hybrid Product Breakdown Structure for NASA Ground Systems

Science.gov (United States)

Monaghan, Mark W.; Henry, Robert J.

2013-01-01

The Product Breakdown Structure is traditionally a method of identification of the products of a project in a tree structure. It is a tool used to assess, plan, document, and display the equipment requirements for a project. It is part of a product based planning technique, and attempts to break down all components of a project in as much detail as possible, so that nothing is overlooked. The PBS for ground systems at the Kennedy Space Center is being developed to encompass the traditional requirements including the alignment of facility, systems, and components to the organizational hierarchy. The Ground Operations Product Breakdown Structure is a hybrid in nature in that some aspects of a work breakdown structure will be incorporated and merged with the Architecture Concept of Operations, Master Subsystem List, customer interface, and assigned management responsibility. The Ground Operations Product Breakdown Structure needs to be able to identify the flexibility of support differing customers (internal and external) usage of ground support equipment within the Kennedy Space Center launch and processing complex. The development of the Product Breakdown Structure is an iterative activity Initially documenting the organization hierarchy structure and relationships. The Product Breakdown Structure identifies the linkage between the customer program requirements, allocation of system resources, development of design goals, and identification logistics products. As the Product Breakdown Structure progresses the incorporation of the results of requirement planning for the customer occurs identifying facility needs and systems. The mature Product Breakdown Structure is baselined with a hierarchical drawing, the Product Breakdown Structure database, and an associated document identifying the verification of the data through the life cycle of the program/product line. This paper will document, demonstrate, and identify key aspects of the life cycle of a Hybrid Product

How to Develop a Multi-Grounded Theory: the evolution of a business process theory

OpenAIRE

Mikael Lind; Goran Goldkuhl

2006-01-01

In the information systems field there is a great need for different theories. Theory development can be performed in different ways – deductively and/or inductively. Different approaches with their pros and cons for theory development exists. A combined approach, which builds on inductive as well as deductive thinking, has been put forward – a Multi-Grounded Theory approach. In this paper the evolution of a business process theory is regarded as the development of a multi-grounded theory. Th...

Exogenous spatial attention influences figure-ground assignment.

Science.gov (United States)

Vecera, Shaun P; Flevaris, Anastasia V; Filapek, Joseph C

2004-01-01

In a hierarchical stage account of vision, figure-ground assignment is thought to be completed before the operation of focal spatial attention. Results of previous studies have supported this account by showing that unpredictive, exogenous spatial precues do not influence figure-ground assignment, although voluntary attention can influence figure-ground assignment. However, in these studies, attention was not summoned directly to a region in a figure-ground display. In three experiments, we addressed the relationship between figure-ground assignment and visuospatial attention. In Experiment 1, we replicated the finding that exogenous precues do not influence figure-ground assignment when they direct attention outside of a figure-ground stimulus. In Experiment 2, we demonstrated that exogenous attention can influence figure-ground assignment if it is directed to one of the regions in a figure-ground stimulus. In Experiment 3, we demonstrated that exogenous attention can influence figure-ground assignment in displays that contain a Gestalt figure-ground cue; this result suggests that figure-ground processes are not entirely completed prior to the operation of focal spatial attention. Exogenous spatial attention acts as a cue for figure-ground assignment and can affect the outcome of figure-ground processes.

Techniques for enhancing durability and equivalence ratio control in a rich-lean, three-stage ground power gas turbine combustor

Science.gov (United States)

Schultz, D. F.

1982-01-01

Rig tests of a can-type combustor were performed to demonstrate two advanced ground power engine combustor concepts: steam cooled rich-burn combustor primary zones for enhanced durability; and variable combustor geometry for three stage combustion equivalence ratio control. Both concepts proved to be highly successful in achieving their desired objectives. The steam cooling reduced peak liner temperatures to less than 800 K. This offers the potential of both long life and reduced use of strategic materials for liner fabrication. Three degrees of variable geometry were successfully implemented to control airflow distribution within the combustor. One was a variable blade angle axial flow air swirler to control primary airflow while the other two consisted of rotating bands to control secondary and tertiary or dilution air flow.

Aerodynamic Analyses and Database Development for Ares I Vehicle First Stage Separation

Science.gov (United States)

Pamadi, Bandu N.; Pei, Jing; Pinier, Jeremy T.; Holland, Scott D.; Covell, Peter F.; Klopfer, Goetz, H.

2012-01-01

This paper presents the aerodynamic analysis and database development for the first stage separation of the Ares I A106 Crew Launch Vehicle configuration. Separate databases were created for the first stage and upper stage. Each database consists of three components: isolated or free-stream coefficients, power-off proximity increments, and power-on proximity increments. The power-on database consists of three parts, all plumes firing at nominal conditions, the one booster deceleration motor out condition, and the one ullage settling motor out condition. The isolated and power-off incremental databases were developed using wind tunnel test data. The power-on proximity increments were developed using CFD solutions.

The role of competence assessment in the different stages of competence development

NARCIS (Netherlands)

Schoonenboom, J.; Tattersall, C.; Miao, Y.; Stefanov, K.; Aleksieva-Petrova, A.; Adelsberger, H.H.; Kinshuk,; Pawlowski, J.M.; Sampson, D.

2008-01-01

This chapter discusses the role of e-assessment in the process of competence development. Its basic claim is that competence development is a process with distinct stages, and that the assessment forms and the roles taken on by those involved in the process depend on the stage in which learning

Assessing the ground vibrations produced by a heavy vehicle traversing a traffic obstacle.

Science.gov (United States)

Ducarne, Loïc; Ainalis, Daniel; Kouroussis, Georges

2018-01-15

Despite advancements in alternative transport networks, road transport remains the dominant mode in many modern and developing countries. The ground-borne motions produced by the passage of a heavy vehicle over a geometric obstacle (e.g. speed hump, train tracks) pose a fundamental problem in transport annoyance in urban areas. In order to predict the ground vibrations generated by the passage of a heavy vehicle over a geometric obstacle, a two-step numerical model is developed. The first step involves simulating the dynamic loads generated by the heavy vehicle using a multibody approach, which includes the tyre-obstacle-ground interaction. The second step involves the simulation of the ground wave propagation using a three dimensional finite element model. The simulation is able to be decoupled due to the large difference in stiffness between the vehicle's tyres and the road. First, the two-step model is validated using an experimental case study available in the literature. A sensitivity analysis is then presented, examining the influence of various factors on the generated ground vibrations. Factors investigated include obstacle shape, obstacle dimensions, vehicle speed, and tyre stiffness. The developed model can be used as a tool in the early planning stages to predict the ground vibrations generated by the passage of a heavy vehicle over an obstacle in urban areas. Copyright © 2017 Elsevier B.V. All rights reserved.

Development and evaluation of an ultrasonic ground water seepage meter.

Science.gov (United States)

Paulsen, R J; Smith, C F; O'Rourke, D; Wong, T F

2001-01-01

Submarine ground water discharge can influence significantly the near-shore transport and flux of chemicals into the oceans. Quantification of the sources and rates of such discharge requires a ground water seepage meter that provides continuous measurements at high resolution over an extended period of time. An ultrasonic flowmeter has been adapted for such measurements in the submarine environment. Connected to a steel collection funnel, the meter houses two piezoelectric transducers mounted at opposite ends of a cylindrical flow tube. By monitoring the perturbations of fluid flow on the propagation of sound waves inside the flow tube, the ultrasonic meter can measure both forward and reverse fluid flows in real time. Laboratory and field calibrations show that the ultrasonic meter can resolve ground water discharges on the order of 0.1 microm/sec, and it is sufficiently robust for deployment in the field for several days. Data from West Neck Bay, Shelter Island, New York, elucidate the temporal and spatial heterogeneity of submarine ground water discharge and its interplay with tidal loading. A negative correlation between the discharge and tidal elevation was generally observed. A methodology was also developed whereby data for the sound velocity as a function of temperature can be used to infer the salinity and source of the submarine discharge. Independent measurements of electrical conductance were performed to validate this methodology.

Seven methods to measure ground moisture

International Nuclear Information System (INIS)

Anon.

1983-01-01

The correct irrigation methods are of great importance to the deciduous fruit grower. The article discusses seven methods for the measuring of ground humidity. These methods are based on gravimetry, electric resistance, gamma attenuation, neutron humidity measurement, tensiometers and a study of the correlation between ground humidity and water evaporation. At this stage, the last technique is regarded as the most practicle method. Neutron moisture gages might be used if adhered to the regulations of NUCOR

Using cow dung and spent coffee grounds to enhance the two-stage co-composting of green waste.

Science.gov (United States)

Zhang, Lu; Sun, Xiangyang

2017-12-01

The objective of this study was to determine the effects of cow dung (CD) (at 0%, 20%, and 35%) and/or spent coffee grounds (SCGs) (at 0%, 30%, and 45%) as amendments in the two-stage co-composting of green waste (GW); the percentages refer to grams of amendment per 100g of GW based on dry weights. The combined addition of CD and SCGs improved the conditions during co-composting and the quality of the compost product in terms of composting temperature; particle-size distribution; mechanical properties; nitrogen changes; low-molecular weight compounds; humic substances; the degradation of lignin, cellulose, and hemicellulose; enzyme activities; the contents of total Kjeldahl nitrogen, total phosphorus, and total potassium; and the toxicity to germinating seeds. The combined addition of 20% CD and 45% SCGs to GW resulted in the production of the highest quality compost product and did so in only 21days. Copyright © 2017 Elsevier Ltd. All rights reserved.

Understanding College Students' Civic Identity Development: A Grounded Theory

Science.gov (United States)

Johnson, Matthew R.

2017-01-01

This article presents the results of a study designed to understand the development of college students' civic identity--that is, an identity encompassing their knowledge, attitudes, values, and actions regarding civic engagement. Grounded theory was used to examine the experiences and attitudes of 19 college seniors who manifested strong civic…

Method development at Nordic School of Public Health NHV: Phenomenology and Grounded Theory.

Science.gov (United States)

Strandmark, Margaretha

2015-08-01

Qualitative methods such as phenomenology and grounded theory have been valuable tools in studying public health problems. A description and comparison of these methods. Phenomenology emphasises an inside perspective in form of consciousness and subjectively lived experiences, whereas grounded theory emanates from the idea that interactions between people create new insights and knowledge. Fundamental aspects of phenomenology include life world, consciousness, phenomenological reduction and essence. Significant elements in grounded theory are coding, categories and core categories, which develop a theory. There are differences in the philosophical approach, the name of the concept and the systematic tools between the methods. Thus, the phenomenological method is appropriate when studying emotional and existential research problems, and grounded theory is a method more suited to investigate processes. © 2015 the Nordic Societies of Public Health.

Ares I-X Ground Diagnostic Prototype

Science.gov (United States)

Schwabacher, Mark A.; Martin, Rodney Alexander; Waterman, Robert D.; Oostdyk, Rebecca Lynn; Ossenfort, John P.; Matthews, Bryan

2010-01-01

The automation of pre-launch diagnostics for launch vehicles offers three potential benefits: improving safety, reducing cost, and reducing launch delays. The Ares I-X Ground Diagnostic Prototype demonstrated anomaly detection, fault detection, fault isolation, and diagnostics for the Ares I-X first-stage Thrust Vector Control and for the associated ground hydraulics while the vehicle was in the Vehicle Assembly Building at Kennedy Space Center (KSC) and while it was on the launch pad. The prototype combines three existing tools. The first tool, TEAMS (Testability Engineering and Maintenance System), is a model-based tool from Qualtech Systems Inc. for fault isolation and diagnostics. The second tool, SHINE (Spacecraft Health Inference Engine), is a rule-based expert system that was developed at the NASA Jet Propulsion Laboratory. We developed SHINE rules for fault detection and mode identification, and used the outputs of SHINE as inputs to TEAMS. The third tool, IMS (Inductive Monitoring System), is an anomaly detection tool that was developed at NASA Ames Research Center. The three tools were integrated and deployed to KSC, where they were interfaced with live data. This paper describes how the prototype performed during the period of time before the launch, including accuracy and computer resource usage. The paper concludes with some of the lessons that we learned from the experience of developing and deploying the prototype.

Short-Term Responses of Ground Beetles to Forest Changes Caused by Early Stages of Emerald Ash Borer (Coleoptera: Buprestidae)-Induced Ash Mortality.

Science.gov (United States)

Perry, Kayla I; Herms, Daniel A

2016-04-22

Emerald ash borer (Agrilus planipennis Fairmaire), an invasive wood-boring beetle native to Asia, has killed hundreds of millions of ash trees since its accidental introduction into North America, resulting in widespread formation of canopy gaps and accumulations of coarse woody debris (CWD) in forests. The objective was to quantify effects of canopy gaps and CWD caused by early stages of emerald ash borer-induced ash mortality, and their interaction on ground beetle assemblages. The impact of canopy gaps and CWD varied, as gaps affected beetle assemblages in 2011, while effects of CWD were only observed in 2012. Gaps decreased beetle activity-abundance, and marginally decreased richness, driving changes in species composition, but evenness and diversity were unaffected. Effects of the CWD treatment alone were minimal, but CWD interacted with the canopy treatment, resulting in an increase in activity-abundance of ground beetles in canopy gaps without CWD, and a marginal increase in species richness in canopy gaps with CWD. Although there were some initial changes in species composition, these were ephemeral, suggesting that ground beetle assemblages may be resilient to disturbance caused by emerald ash borer. This study contributes to our understanding of the cascading ecological impacts of biological invasions on forest ecosystems. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

Science.gov (United States)

Vaughan, Ashley M.; Mikolajczak, Sebastian A.; Wilson, Elizabeth M.; Grompe, Markus; Kaushansky, Alexis; Camargo, Nelly; Bial, John; Ploss, Alexander; Kappe, Stefan H.I.

2012-01-01

Plasmodium falciparum, which causes the most lethal form of human malaria, replicates in the host liver during the initial stage of infection. However, in vivo malaria liver-stage (LS) studies in humans are virtually impossible, and in vitro models of LS development do not reconstitute relevant parasite growth conditions. To overcome these obstacles, we have adopted a robust mouse model for the study of P. falciparum LS in vivo: the immunocompromised and fumarylacetoacetate hydrolase–deficient mouse (Fah–/–, Rag2–/–, Il2rg–/–, termed the FRG mouse) engrafted with human hepatocytes (FRG huHep). FRG huHep mice supported vigorous, quantifiable P. falciparum LS development that culminated in complete maturation of LS at approximately 7 days after infection, providing a relevant model for LS development in humans. The infections allowed observations of previously unknown expression of proteins in LS, including P. falciparum translocon of exported proteins 150 (PTEX150) and exported protein-2 (EXP-2), components of a known parasite protein export machinery. LS schizonts exhibited exoerythrocytic merozoite formation and merosome release. Furthermore, FRG mice backcrossed to the NOD background and repopulated with huHeps and human red blood cells supported reproducible transition from LS infection to blood-stage infection. Thus, these mice constitute reliable models to study human LS directly in vivo and demonstrate utility for studies of LS–to–blood-stage transition of a human malaria parasite. PMID:22996664

Ground water currents: Developments in innovative ground water treatment, March 1994

Energy Technology Data Exchange (ETDEWEB)

Eilers, R.

1994-03-01

;Contents: Hydrodynamic cavitation oxidation destroys organics; Biosparging documented in fuel remediation study; Surfactant flushing research to remove organic liquids from aquifers; and Compilation of Ground-Water Models (a book review).

Cadmium uptake in above-ground parts of lettuce (Lactuca sativa L.).

Science.gov (United States)

Tang, Xiwang; Pang, Yan; Ji, Puhui; Gao, Pengcheng; Nguyen, Thanh Hung; Tong, Yan'an

2016-03-01

Because of its high Cd uptake and translocation, lettuce is often used in Cd contamination studies. However, there is a lack of information on Cd accumulation in the above-ground parts of lettuce during the entire growing season. In this study, a field experiment was carried out in a Cd-contaminated area. Above-ground lettuce parts were sampled, and the Cd content was measured using a flame atomic absorption spectrophotometer (AAS). The results showed that the Cd concentration in the above-ground parts of lettuce increased from 2.70 to 3.62mgkg(-1) during the seedling stage, but decreased from 3.62 to 2.40mgkg(-1) during organogenesis and from 2.40 to 1.64mgkg(-1) during bolting. The mean Cd concentration during the seedling stage was significantly higher than that during organogenesis (a=0.05) and bolting (a=0.01). The Cd accumulation in the above-ground parts of an individual lettuce plant could be described by a sigmoidal curve. Cadmium uptake during organogenesis was highest (80% of the total), whereas that during bolting was only 4.34%. This research further reveals that for Rome lettuce: (1) the highest Cd content of above-ground parts occurred at the end of the seedling phase; (2) the best harvest time with respect to Cd phytoaccumulation is at the end of the organogenesis stage; and (3) the organogenesis stage is the most suitable time to enhance phytoaccumulation efficiency by adjusting the root:shoot ratio. Copyright © 2015 Elsevier Inc. All rights reserved.

Theoretical Grounds of Identification of the Essence of the Enterprise Development Efficiency Category

Directory of Open Access Journals (Sweden)

Adzhavenko Maryna M.

2014-02-01

Full Text Available Modern economic conditions put a new problem in front of scientists, namely: capability of an enterprise to survive in the unfavourable external environment. This problem is a system and complex one and its solution is within the plane of management of capital, personnel, development, efficiency, etc. The article marks out that efficiency is a corner stone of the modern economic science, which justifies studies of the gnoseological essence of the efficiency category. The main goal of the article lies in the study of scientific and theoretical grounds of formation of the enterprise development efficiency under modern conditions of the changing internal and external environments. The other goals of the article are identification of the essence of the development efficiency category, deepening the theoretical foundation of assessment of efficiency of enterprise development in the modern economic science. The article conducts an ontological analysis of the essence and goals of the enterprise development efficiency notion, studies evolution of scientific approaches and systemises theoretical provisions of the specified category and their assessment in the economic science. In the result of the study the article identifies a new vector of theoretical grounds and dominating logic of formation of the methodology of assessment of efficiency of enterprises under conditions of innovation development of the state, namely: it underlines principles of systemacy, complexity, self-organisation, significance of human capital as an important factor of increase of efficiency and development. Development of methodological grounds of assessment of efficiency of enterprise innovation development is a prospective direction of further studies.

Two critical periods in early visual cortex during figure–ground segregation

OpenAIRE

Wokke, Martijn E; Sligte, Ilja G; Steven Scholte, H; Lamme, Victor A F

2012-01-01

.The ability to distinguish a figure from its background is crucial for visual perception. To date, it remains unresolved where and how in the visual system different stages of figure-ground segregation emerge. Neural correlates of figure border detection have consistently been found in early visual cortex (V1/V2). However, areas V1/V2 have also been frequently associated with later stages of figure-ground segregation (such as border ownership or surface segregation). To causally link activit...

Understanding the Conceptual Development Phase of Applied Theory-Building Research: A Grounded Approach

Science.gov (United States)

Storberg-Walker, Julia

2007-01-01

This article presents a provisional grounded theory of conceptual development for applied theory-building research. The theory described here extends the understanding of the components of conceptual development and provides generalized relations among the components. The conceptual development phase of theory-building research has been widely…

Development of a PC-based ground support system for a small satellite instrument

Science.gov (United States)

Deschambault, Robert L.; Gregory, Philip R.; Spenler, Stephen; Whalen, Brian A.

1993-11-01

The importance of effective ground support for the remote control and data retrieval of a satellite instrument cannot be understated. Problems with ground support may include the need to base personnel at a ground tracking station for extended periods, and the delay between the instrument observation and the processing of the data by the science team. Flexible solutions to such problems in the case of small satellite systems are provided by using low-cost, powerful personal computers and off-the-shelf software for data acquisition and processing, and by using Internet as a communication pathway to enable scientists to view and manipulate satellite data in real time at any ground location. The personal computer based ground support system is illustrated for the case of the cold plasma analyzer flown on the Freja satellite. Commercial software was used as building blocks for writing the ground support equipment software. Several levels of hardware support, including unit tests and development, functional tests, and integration were provided by portable and desktop personal computers. Satellite stations in Saskatchewan and Sweden were linked to the science team via phone lines and Internet, which provided remote control through a central point. These successful strategies will be used on future small satellite space programs.

Implementing national nuclear safety plan at the preliminary stage of nuclear power project development

International Nuclear Information System (INIS)

Xue Yabin; Cui Shaozhang; Pan Fengguo; Zhang Lizhen; Shi Yonggang

2014-01-01

This study discusses the importance of nuclear power project design and engineering methods at the preliminary stage of its development on nuclear power plant's operational safety from the professional view. Specifically, we share our understanding of national nuclear safety plan's requirement on new reactor accident probability, technology, site selection, as well as building and improving nuclear safety culture and strengthening public participation, with a focus on plan's implications on preliminary stage of nuclear power project development. Last, we introduce China Huaneng Group's work on nuclear power project preliminary development and the experience accumulated during the process. By analyzing the siting philosophy of nuclear power plant and the necessity of building nuclear safety culture at the preliminary stage of nuclear power project development, this study explicates how to fully implement the nuclear safety plan's requirements at the preliminary stage of nuclear power project development. (authors)

Using XML Configuration-Driven Development to Create a Customizable Ground Data System

Science.gov (United States)

Nash, Brent; DeMore, Martha

2009-01-01

The Mission data Processing and Control Subsystem (MPCS) is being developed as a multi-mission Ground Data System with the Mars Science Laboratory (MSL) as the first fully supported mission. MPCS is a fully featured, Java-based Ground Data System (GDS) for telecommand and telemetry processing based on Configuration-Driven Development (CDD). The eXtensible Markup Language (XML) is the ideal language for CDD because it is easily readable and editable by all levels of users and is also backed by a World Wide Web Consortium (W3C) standard and numerous powerful processing tools that make it uniquely flexible. The CDD approach adopted by MPCS minimizes changes to compiled code by using XML to create a series of configuration files that provide both coarse and fine grained control over all aspects of GDS operation.

TWO-STAGE HEAT PUMPS FOR ENERGY SAVING TECHNOLOGIES

Directory of Open Access Journals (Sweden)

A. E. Denysova

2017-09-01

Full Text Available The problem of energy saving becomes one of the most important in power engineering. It is caused by exhaustion of world reserves in hydrocarbon fuel, such as gas, oil and coal representing sources of traditional heat supply. Conventional sources have essential shortcomings: low power, ecological and economic efficiencies, that can be eliminated by using alternative methods of power supply, like the considered one: low-temperature natural heat of ground waters of on the basis of heat pump installations application. The heat supply system considered provides an effective use of two stages heat pump installation operating as heat source at ground waters during the lowest ambient temperature period. Proposed is a calculation method of heat pump installations on the basis of groundwater energy. Calculated are the values of electric energy consumption by the compressors’ drive, and the heat supply system transformation coefficient µ for a low-potential source of heat from ground waters allowing to estimate high efficiency of two stages heat pump installations.

Development of a three-dimensional ground-water model of the Hanford Site unconfined aquifer system: FY 1995 status report

International Nuclear Information System (INIS)

Wurstner, S.K.; Thorne, P.D.; Chamness, M.A.; Freshley, M.D.; Williams, M.D.

1995-12-01

A three-dimensional numerical model of ground-water flow was developed for the uppermost unconfined aquifer at the Hanford Site in south-central Washington. Development of the model is supported by the Hanford Site Ground-Water Surveillance Project, managed by the Pacific Northwest National Laboratory, which is responsible for monitoring the sitewide movement of contaminants in ground water beneath the Hanford Site. Two objectives of the Ground-Water Surveillance Project are to (1) identify and quantify existing, emerging, or potential ground-water quality problems, and (2) assess the potential for contaminants to migrate from the Hanford Site through the ground-water pathway. Numerical models of the ground-water flow system are important tools for estimating future aquifer conditions and predicting the movement of contaminants through ground water. The Ground-Water Surveillance Project has supported development and maintenance of a two-dimensional model of the unconfined aquifer. This report describes upgrade of the two-dimensional model to a three-dimensional model. The numerical model is based on a three-dimensional conceptual model that will be continually refined and updated as additional information becomes available. This report presents a description of the three-dimensional conceptual model of ground-water flow in the unconfined aquifer system and then discusses the cur-rent state of the three-dimensional numerical model

Methodological Grounds of Managing Innovation Development of Restaurants

Directory of Open Access Journals (Sweden)

Naidiuk V. S.

2013-12-01

Full Text Available The goal of the article lies in identification and further development of methodological grounds of managing the innovation development of restaurants. Based on the data of the critical analysis of existing scientific views on interpretation of the essence of the “managing innovation development of an enterprise” notion, the article conducts clarification of this definition. In the result of the study the article builds up a cause-effect diagram of solution of the problem of ensuring efficient management of the innovation development of a restaurant. The article develops a conceptual scheme of development and realisation of the strategy of innovation development in a restaurant. It experimentally confirms the hypothesis of availability of a very strong density of the feedback between resistance to innovation changes and a variable share of qualified personnel that is capable of permanent development (learning and generation of new ideas, in restaurants and builds a model of dependency between them. The prospects of further studies in this direction could become scientific studies directed at development of methodical approaches to identification of the level of innovation potential and assessment of efficiency of managing innovation development of different (by type, class, size, etc. restaurants. The obtained data could also be used for development of a new or improvement of the existing tools of strategic management of innovation development at the micro-level.

Evolution of Fractal Parameters through Development Stage of Soil Crust

Science.gov (United States)

Ospina, Abelardo; Florentino, Adriana; Tarquis, Ana Maria

2016-04-01

Soil surface characteristics are subjected to changes driven by several interactions between water, air, biotic and abiotic components. One of the examples of such interactions is provided through biological soil crusts (BSC) in arid and semi-arid environments. BSC are communities composed of cyanobacteria, fungi, mosses, lichens, algae and liverworts covering the soil surface and play an important role in ecosystem functioning. The characteristics and formation of these BSC influence the soil hydrological balance, control the mass of eroded sediment, increase stability of soil surface, and influence plant productivity through the modification of nitrogen and carbon cycle. The site of this work is located at Quibor and Ojo de Agua (Lara state, Venezuela). The Quibor Depression in Venezuela is a major agricultural area being at semi-arid conditions and limited drainage favor the natural process of salinization. Additionally, the extension and intensification of agriculture has led to over-exploitation of groundwater in the past 30 years (Méndoza et al., 2013). The soil microbial crust develops initially on physical crusts which are mainly generated since wetting and drying, being a recurrent feature in the Quíbor arid zone. The microbiotic crust is organic, composed of macro organisms (bryophytes and lichens) and microorganisms (cyanobacteria, fungi algae, etc.); growing on the ground, forming a thickness no greater than 3 mm. For further details see Toledo and Florentino (2009). This study focus on characterize the development stage of the BSC based on image analysis. To this end, grayscale images of different types of biological soil crust at different stages where taken, each image corresponding to an area of 12.96 cm2 with a resolution of 1024x1024 pixels (Ospina et al., 2015). For each image lacunarity and fractal dimension through the differential box counting method were calculated. These were made with the software ImageJ/Fraclac (Karperien, 2013

Newly-graduated midwives transcending barriers: a grounded theory study.

Science.gov (United States)

Barry, Michele J; Hauck, Yvonne L; O'Donoghue, Thomas; Clarke, Simon

2013-12-01

Midwifery has developed its own philosophy to formalise its unique identity as a profession. Newly-graduated midwives are taught, and ideally embrace, this philosophy during their education. However, embarking in their career within a predominantly institutionalised and the medically focused health-care model may challenge this application. The research question guiding this study was as follows: 'How do newly graduated midwives deal with applying the philosophy of midwifery in their first six months of practice?' The aim was to generate a grounded theory around this social process. This Western Australian grounded theory study is conceptualised within the social theory of symbolic interactionism. Data were collected by means of in-depth, semi-structured interviews with 11 recent midwifery graduates. Participant and interviewer's journals provided supplementary data. The 'constant comparison' approach was used for data analysis. The substantive theory of transcending barriers was generated. Three stages in transcending barriers were identified: Addressing personal attributes, Understanding the 'bigger picture', and finally, 'Evaluating, planning and acting' to provide woman-centred care. An overview of these three stages provides the focus of this article. The theory of transcending barriers provides a new perspective on how newly-graduated midwives deal with applying the philosophy of midwifery in their first six months of practice. A number of implications for pre and post registration midwifery education and policy development are suggested, as well as recommendations for future research. Copyright © 2013 Elsevier Ltd. All rights reserved.

A Hybrid Ground-Motion Prediction Equation for Earthquakes in Western Alberta

Science.gov (United States)

Spriggs, N.; Yenier, E.; Law, A.; Moores, A. O.

2015-12-01

Estimation of ground-motion amplitudes that may be produced by future earthquakes constitutes the foundation of seismic hazard assessment and earthquake-resistant structural design. This is typically done by using a prediction equation that quantifies amplitudes as a function of key seismological variables such as magnitude, distance and site condition. In this study, we develop a hybrid empirical prediction equation for earthquakes in western Alberta, where evaluation of seismic hazard associated with induced seismicity is of particular interest. We use peak ground motions and response spectra from recorded seismic events to model the regional source and attenuation attributes. The available empirical data is limited in the magnitude range of engineering interest (M>4). Therefore, we combine empirical data with a simulation-based model in order to obtain seismologically informed predictions for moderate-to-large magnitude events. The methodology is two-fold. First, we investigate the shape of geometrical spreading in Alberta. We supplement the seismic data with ground motions obtained from mining/quarry blasts, in order to gain insights into the regional attenuation over a wide distance range. A comparison of ground-motion amplitudes for earthquakes and mining/quarry blasts show that both event types decay at similar rates with distance and demonstrate a significant Moho-bounce effect. In the second stage, we calibrate the source and attenuation parameters of a simulation-based prediction equation to match the available amplitude data from seismic events. We model the geometrical spreading using a trilinear function with attenuation rates obtained from the first stage, and calculate coefficients of anelastic attenuation and site amplification via regression analysis. This provides a hybrid ground-motion prediction equation that is calibrated for observed motions in western Alberta and is applicable to moderate-to-large magnitude events.

Using grounded theory as a method for rigorously reviewing literature

NARCIS (Netherlands)

Wolfswinkel, J.; Furtmueller-Ettinger, Elfriede; Wilderom, Celeste P.M.

2013-01-01

This paper offers guidance to conducting a rigorous literature review. We present this in the form of a five-stage process in which we use Grounded Theory as a method. We first probe the guidelines explicated by Webster and Watson, and then we show the added value of Grounded Theory for rigorously

Ground System Architectures Workshop GMSEC SERVICES SUITE (GSS): an Agile Development Story

Science.gov (United States)

Ly, Vuong

2017-01-01

The GMSEC (Goddard Mission Services Evolution Center) Services Suite (GSS) is a collection of tools and software services along with a robust customizable web-based portal that enables the user to capture, monitor, report, and analyze system-wide GMSEC data. Given our plug-and-play architecture and the needs for rapid system development, we opted to follow the Scrum Agile Methodology for software development. Being one of the first few projects to implement the Agile methodology at NASA GSFC, in this presentation we will present our approaches, tools, successes, and challenges in implementing this methodology. The GMSEC architecture provides a scalable, extensible ground and flight system for existing and future missions. GMSEC comes with a robust Application Programming Interface (GMSEC API) and a core set of Java-based GMSEC components that facilitate the development of a GMSEC-based ground system. Over the past few years, we have seen an upbeat in the number of customers who are moving from a native desktop application environment to a web based environment particularly for data monitoring and analysis. We also see a need to provide separation of the business logic from the GUI display for our Java-based components and also to consolidate all the GUI displays into one interface. This combination of separation and consolidation brings immediate value to a GMSEC-based ground system through increased ease of data access via a uniform interface, built-in security measures, centralized configuration management, and ease of feature extensibility.

Development and tests of fast 1-MA linear transformer driver stages

Directory of Open Access Journals (Sweden)

A. A. Kim

2009-05-01

Full Text Available In this article we present the design and test results of the most powerful, fast linear transformer driver (LTD stage developed to date. This 1-MA LTD stage consists of 40 parallel RLC (resistor R, inductor L, and capacitor C circuits called “bricks” that are triggered simultaneously; it is able to deliver ∼1  MA current pulse with a rise time of ∼100  ns into the ∼0.1-Ohm matched load. The electrical behavior of the stage can be predicted by using a simple RLC circuit, thus simplifying the designing of various LTD-based accelerators. Five 1-MA LTD stages assembled in series into a module have been successfully tested with both resistive and vacuum electron-beam diode loads.

How nursing home residents develop relationships with peers and staff: a grounded theory study.

Science.gov (United States)

Roberts, Tonya; Bowers, Barbara

2015-01-01

Social support and social relationships have been repeatedly identified as essential to nursing home resident quality of life. However, little is known about ways residents develop relationships with peers or staff. This study was conducted to explore the ways resident develop relationships with peers and staff in nursing homes. Fifteen cognitively intact nursing home residents from two facilities were interviewed for this grounded theory study. Sampling, interviewing, and analysis occurred in a cyclical process with results at each stage of the study informing decisions about data collection and analysis in the next. Unstructured interviews and field observations were conducted. Data were analyzed with open, axial, and selective coding. Residents developed relationships with peers and staff largely as an unintended consequence of trying to have a life in the nursing home. Having a life was a two-step process. First, life motivations (Being Self and Creating a Positive Atmosphere) influenced resident preferences for daily activities and interaction goals and subsequently their strategies for achieving and establishing both. Second, the strategies residents used for achieving their required daily activities (Passing Time and Getting Needs Met) and interaction goals then influenced the nature of interaction and the subsequent peer or staff response to these interactions. Residents defined relationships as friendly or unfriendly depending on whether peers or staff responded positively or negatively. There was considerable overlap in the ways peer and staff relationships developed and the results highlight the role of peer and staff responsiveness in relationship development. The results provide possible explanations for the success of interventions in the literature designed to improve staff responsiveness to residents. The results suggest that adapting these kinds of interventions for use with peers may also be successful. The conceptual model also presents a number

Development of a Ground Test and Analysis Protocol for NASA's NextSTEP Phase 2 Habitation Concepts

Science.gov (United States)

Gernhardt, Michael L.; Beaton, Kara H.; Chappell, Steven P.; Bekdash, Omar S.; Abercromby, Andrew F. J.

2018-01-01

The NASA Next Space Technologies for Exploration Partnerships (NextSTEP) program is a public-private partnership model that seeks commercial development of deep space exploration capabilities to support human spaceflight missions around and beyond cislunar space. NASA first issued the Phase 1 NextSTEP Broad Agency Announcement to U.S. industries in 2014, which called for innovative cislunar habitation concepts that leveraged commercialization plans for low-Earth orbit. These habitats will be part of the Deep Space Gateway (DSG), the cislunar space station planned by NASA for construction in the 2020s. In 2016, Phase 2 of the NextSTEP program selected five commercial partners to develop ground prototypes. A team of NASA research engineers and subject matter experts (SMEs) have been tasked with developing the ground-test protocol that will serve as the primary means by which these Phase 2 prototypes will be evaluated. Since 2008, this core test team has successfully conducted multiple spaceflight analog mission evaluations utilizing a consistent set of operational tools, methods, and metrics to enable the iterative development, testing, analysis, and validation of evolving exploration architectures, operations concepts, and vehicle designs. The purpose of implementing a similar evaluation process for the Phase 2 Habitation Concepts is to consistently evaluate different commercial partner ground prototypes to provide data-driven, actionable recommendations for Phase 3. This paper describes the process by which the ground test protocol was developed and the objectives, methods, and metrics by which the NextSTEP Phase 2 Habitation Concepts will be rigorously and systematically evaluated. The protocol has been developed using both a top-down and bottom-up approach. Top-down development began with the Human Exploration and Operations Mission Directorate (HEOMD) exploration objectives and ISS Exploration Capability Study Team (IECST) candidate flight objectives. Strategic

Development of an international schedule for the assessment and staging of care for dementia

NARCIS (Netherlands)

Semrau, M.; Burns, A.; Djukic-Dejanovic, S.; Eraslan, D.; Han, C.; Lecic-Tosevski, D.; Lobo, A.; Mihai, A.; Morris, J.; Palumbo, C.; Robert, P.; Stiens, G.; Stoppe, G.; Volpe, U.; Olde Rikkert, M.G.M.; Sartorius, N.

2015-01-01

BACKGROUND: A reliable and valid global staging scale has been lacking within dementia care. OBJECTIVE: To develop an easy-to-use multi-dimensional clinical staging schedule for dementia. METHODS: The schedule was developed through: i) Two series of focus groups (40 and 48 participants,

Stages of educational development? Beeby revisited

Science.gov (United States)

Guthrie, Gerard

1980-12-01

Beeby's model of stages of educational change in developing countries has been accepted into the educational literature with remarkably little critical analysis. Though valuable for a large number of experiential insights, the author argues that the model has certain weaknesses which should restrict its application. The stages have a teleological bias and are not sufficiently distinct, nor do the labels used for them meet the formal requirements of measuring scales. Furthermore, the model overgeneralizes from the experience of British-tradition South Pacific school systems, and the equation of western teaching with good teaching is an unsupported view which may not be valid in many countries. The most fundamental problem is the lack of clear distinction between empirical issues and the ethical judgements implicit in the formulation. However, the model has a number of positive features well worth building upon, such as its focus on the qualitative aspects of teaching and on qualitative change, the realistic emphasis on the gradualism of such change in practice, and the identification of the teacher as the key change agent in the classroom — a fundamental point often overlooked by innovators. The continua of general and professional education which underlie the teaching styles provide useful hypotheses for empirical analysis of the relationship between teacher education and classroom teaching style, but the association of this education with certain types of teaching style needs careful examination. Stripped of its evaluative connotations, Beeby's interest in qualitative change was a valuable early attempt to move attention in developing countries from linear, quantitative expansion of existing systems to a consideration of what was actually being taught and how. The real lesson to be learned from his work is that education should be paying closer attention to its theoretical propositions.

The Steksovo II burial ground

Directory of Open Access Journals (Sweden)

Martianov Vladimir N.

2014-12-01

Full Text Available The article is dedicated to the results of many-years’ (1990-2010 excavations on the ancient Mordovian Steksovo II burial ground site. The burial ground had functioned in the 3rd to 13th centuries AD. The investigations revealed hundreds of burials, which enabled the researchers to judge upon the wealth of material items found and the variety of burial rites of the population that had formed the burial ground. The 1st millennium AD is characterized by bi-ritualism, while inhumation is characteristic of the 11-13th-century period; horses’ burials were also discovered. The data of the burial ground make it possible to modify the concept of the stages in ancient Mordovians ethnogenesis. It is generally attributed to the Erzya Mordvins, but in early burials the combination of the Erzya and Moksha ancientries is traced. Complexes of the items of crucial importance for the chronology of the burial are discussed in the article with a representation of statistical data characterizing funeral rites and traditions.

Preservation by ionization of refrigerated vacuum-packed ground beef

International Nuclear Information System (INIS)

Soualhia, Z.

1998-01-01

The application of doses of 1, 2, 3, 4, 5 KGy is interesting to lower significantly the contamination microbial flora in ground beef without changing significantly for all that original qualities. Treatment combining ionization (5 KGy) and / or salting (2 %) increases of almost 2 months the duration of refrigerated conservation of Vacuum-packed ground beef with no major change in initial quality. In ionized beef (5 KGy) and / or salted (2 %), the rate of psychotropic germs stays inferior to the threshold superficial putrefaction at all conservation stages. Moreover, faecal contamination pilots, mouldiness, yeast and pathogenic micro-organisms are totally absent in treated samples. Reduction effect of salt is observed at all stages of refrigerated storage. Finally, after cooking, ionizing dose does not change significantly loss of weight and pH of ground beef heated at 100 degrees C in bain-marie or 150 degrees C in drying over during one hour (author)

A development of time-resolved emulsion detector by multi-stage shifter

International Nuclear Information System (INIS)

Takahashi, Satoru; Aoki, Shigeki

2017-01-01

Nuclear emulsion is a powerful tracking device that can record the three-dimensional trajectory of charged particles within 1 μm spatial resolution. We are promoting GRAINE project which is 10 MeV-100 GeV cosmic γ-ray observations with a precise (0.08deg at 1-2 GeV) and polarization-sensitive large-aperture-area (∼10 m 2 ) emulsion telescope by repeating long duration balloon flights. We are developing multi-stage shifter which allows us to give a timing information to emulsion tracks with ∼seconds or below. The multi-stage shifter opened feasibilities of precise cosmic γ-ray observations, GRAINE, as well as precise measurements of ν-N interactions, J-PARC T60. ∼Millisecond time resolution in a balloon-borne experiment, ∼second time resolution for 126.7 days in an accelerator ν experiment and ∼10 6 time-resolved numbers are being achieved. New model of multi-stage shifter is also being developed for future experiments. (author)

Development of SIR-C Ground Calibration Equipment

Science.gov (United States)

Freeman, A.; Azeem, M.; Haub, D.; Sarabandi, K.

1993-01-01

SIR-C/X-SAR is currently scheduled for launch in April 1994. SIR-C is an L-Band and C-Band, multi-polarization spaceborne SAR system developed by NASA/JPL. X- SAR is an X-Band SAR system developed by DARA/ASI. One of the problems involved in calibrating the SIR-C instrument is to make sure that the horizontal (H) and vertical (V) polarized beams are aligned in the azimuth direction, i.e.. that they are pointing in the same direction. This is important if the polarimetric performance specifications for the system are to be met. To solve this problem, we have designed and built a prototype of a low-cost ground receiver capable of recording received power from two antennas, one H-polarized, the other V-polarized. The two signals are mixed to audio then recorded on the left and right stereo channels of a standard audio cassette player. The audio cassette recording can then be played back directly into a Macintosh computer, where it is digitized. Analysis of.

An empirical test of stage models of e-government development: evidence from Dutch municipalities

NARCIS (Netherlands)

Rooks, G.; Matzat, U.; Sadowski, B.M.

2017-01-01

In this article we empirically test stage models of e-government development. We use Lee's classification to make a distinction between four stages of e-government: informational, requests, personal, and e-democracy. We draw on a comprehensive data set on the adoption and development of e-government

A Concept of Two-Stage-To-Orbit Reusable Launch Vehicle

Science.gov (United States)

Yang, Yong; Wang, Xiaojun; Tang, Yihua

2002-01-01

Reusable Launch Vehicle (RLV) has a capability of delivering a wide rang of payload to earth orbit with greater reliability, lower cost, more flexibility and operability than any of today's launch vehicles. It is the goal of future space transportation systems. Past experience on single stage to orbit (SSTO) RLVs, such as NASA's NASP project, which aims at developing an rocket-based combined-cycle (RBCC) airplane and X-33, which aims at developing a rocket RLV, indicates that SSTO RLV can not be realized in the next few years based on the state-of-the-art technologies. This paper presents a concept of all rocket two-stage-to-orbit (TSTO) reusable launch vehicle. The TSTO RLV comprises an orbiter and a booster stage. The orbiter is mounted on the top of the booster stage. The TSTO RLV takes off vertically. At the altitude about 50km the booster stage is separated from the orbiter, returns and lands by parachutes and airbags, or lands horizontally by means of its own propulsion system. The orbiter continues its ascent flight and delivers the payload into LEO orbit. After completing orbit mission, the orbiter will reenter into the atmosphere, automatically fly to the ground base and finally horizontally land on the runway. TSTO RLV has less technology difficulties and risk than SSTO, and maybe the practical approach to the RLV in the near future.

The Onset of Representation and Entry into Stage 6 of Object Permanence Development

Science.gov (United States)

Campos, Joseph J.; Ramsay, Douglas S.

1978-01-01

Attempts to determine whether infants' performance in two search tasks is related to their entry into Stage 6 of object permanence development (thereby testing Piaget's claim that only Stage 6 infants possess the capacity for representation). (BD)

Probabilistic seismic hazard assessment for the effect of vertical ground motions on seismic response of highway bridges

Science.gov (United States)

Yilmaz, Zeynep

Typically, the vertical component of the ground motion is not considered explicitly in seismic design of bridges, but in some cases the vertical component can have a significant effect on the structural response. The key question of when the vertical component should be incorporated in design is answered by the probabilistic seismic hazard assessment study incorporating the probabilistic seismic demand models and ground motion models. Nonlinear simulation models with varying configurations of an existing bridge in California were considered in the analytical study. The simulation models were subjected to the set of selected ground motions in two stages: at first, only horizontal components of the motion were applied; while in the second stage the structures were subjected to both horizontal and vertical components applied simultaneously and the ground motions that produced the largest adverse effects on the bridge system were identified. Moment demand in the mid-span and at the support of the longitudinal girder and the axial force demand in the column are found to be significantly affected by the vertical excitations. These response parameters can be modeled using simple ground motion parameters such as horizontal spectral acceleration and vertical spectral acceleration within 5% to 30% error margin depending on the type of the parameter and the period of the structure. For a complete hazard assessment, both of these ground motion parameters explaining the structural behavior should also be modeled. For the horizontal spectral acceleration, Abrahamson and Silva (2008) model was used within many available standard model. A new NGA vertical ground motion model consistent with the horizontal model was constructed. These models are combined in a vector probabilistic seismic hazard analyses. Series of hazard curves developed and presented for different locations in Bay Area for soil site conditions to provide a roadmap for the prediction of these features for future

GROUNDED THEORY METHODOLOGY and GROUNDED THEORY RESEARCH in TURKEY

OpenAIRE

ARIK, Ferhat; ARIK, Işıl Avşar

2016-01-01

This research discusses the historical development of the Grounded Theory Methodology, which is one of the qualitative research method, its transformation over time and how it is used as a methodology in Turkey. The Grounded Theory which was founded by Strauss and Glaser, is a qualitative methodology based on inductive logic to discover theories in contrast with the deductive understanding which is based on testing an existing theory in sociology. It is possible to examine the Grounded Theory...

Development of a package program for estimating ground level concentrations of radioactive gases

International Nuclear Information System (INIS)

Nilkamhang, W.

1986-01-01

A package program for estimating ground level concentration of radioactive gas from elevate release was develop for use on IBM P C microcomputer. The main program, GAMMA PLUME NT10, is based on the well known VALLEY MODEL which is a Fortran computer code intended for mainframe computers. Other two options were added, namely, calculation of radioactive gas ground level concentration in Ci/m 3 and dose equivalent rate in mren/hr. In addition, a menu program and editor program were developed to render the program easier to use since the option could be readily selected and the input data could be easily modified as required through the keyboard. The accuracy and reliability of the program is almost identical to the mainframe. Ground level concentration of radioactive radon gas due to ore program processing in the nuclear chemistry laboratory of the Department of Nuclear Technology was estimated. In processing radioactive ore at a rate of 2 kg/day, about 35 p Ci/s of radioactive gas was released from a 14 m stack. When meteorological data of Don Muang (average for 5 years 1978-1982) were used maximum ground level concentration and the dose equivalent rate were found to be 0.00094 p Ci/m 3 and 5.0 x 10 -10 mrem/hr respectively. The processing time required for the above problem was about 7 minutes for any case of source on IBM P C which was acceptable for a computer of this class

Development of Ground Test System For RKX-200EB

Science.gov (United States)

Yudhi Irwanto, Herma

2018-04-01

After being postponed for seven years, the development of RKX-200EB now restarts by initiating a ground test, preceding the real flight test. The series of the development starts from simulation test using the real vehicle and its components, focusing on a flight sequence test using hardware in the loop simulation. The result of the simulation shows that the autonomous control system in development is able to control the X tail fin vehicle, since take off using booster, separating booster-sustainer, making flight maneuver using sustainer with average cruise speed of 1000 km/h, and doing bank to maneuver up to ±40 deg heading to the target. The simulation result also shows that the presence of sustainer in vehicle control can expand the distance range by 162% (12.6 km) from its ballistic range using only a booster.

The development of co-innovation strategies: stages and interaction patterns in interfirm innovation

NARCIS (Netherlands)

Bossink, B.A.G.

2002-01-01

Organizations that choose or are forced to innovate in co-operation withother organizations, go through four stages of co-innovation strategy development.The stages are successively: (1) autonomous strategy making: organizations developstrategies on their own, (2) co-operative strategy making:

Reaching for the stars - New developments in ground-based astronomy

CERN Document Server

CERN. Geneva

2015-01-01

I will briefly review the state-of-the-art in ground-based astronomy - both on the telescope side and the instrument side. Interesting parallels can be drawn in cost, construction and operations with the particle physics facilities. I will then present some recent results in the two hottest topics in astronomy, driving the requests for more advanced facilities: exoplanets and the hunt for life beyond the solar system (calling for Extremely Large Telescope); and cosmology and the understanding of dark energy (calling for large survey telescopes). This will lead to a description of the latest telescope project developments on the ground: the on-going construction of the Large Synoptic Telescope on a quest to better understand dark energy, and the start of the construction of three Extremely Large Telescopes by European and US-led international consortia, hoping to find life on planets around nearby stars.   ATS Seminars Organisers: H. Burkhardt (BE), M. Modena (TE), T. Stora (EN) Coffee / tea will ...

Efficiency of optical-electronic systems: methods application for the analysis of structural changes in the process of eye grounds diagnosis

Science.gov (United States)

Saldan, Yosyp R.; Pavlov, Sergii V.; Vovkotrub, Dina V.; Saldan, Yulia Y.; Vassilenko, Valentina B.; Mazur, Nadia I.; Nikolaichuk, Daria V.; Wójcik, Waldemar; Romaniuk, Ryszard; Suleimenov, Batyrbek; Bainazarov, Ulan

2017-08-01

Process of eye tomogram obtaining by means of optical coherent tomography is studied. Stages of idiopathic macula holes formation in the process of eye grounds diagnostics are considered. Main stages of retina pathology progression are determined: Fuzzy logic units for obtaining reliable conclusions regarding the result of diagnosis are developed. By the results of theoretical and practical research system and technique of retinal macular region of the eye state analysis is developed ; application of the system, based on fuzzy logic device, improves the efficiency of eye retina complex.

Ground-Water System in the Chimacum Creek Basin and Surface Water/Ground Water Interaction in Chimacum and Tarboo Creeks and the Big and Little Quilcene Rivers, Eastern Jefferson County, Washington

Science.gov (United States)

Simonds, F. William; Longpre, Claire I.; Justin, Greg B.

2004-01-01

A detailed study of the ground-water system in the unconsolidated glacial deposits in the Chimacum Creek Basin and the interactions between surface water and ground water in four main drainage basins was conducted in eastern Jefferson County, Washington. The study will assist local watershed planners in assessing the status of the water resources and the potential effects of ground-water development on surface-water systems. A new surficial geologic map of the Chimacum Creek Basin and a series of hydrogeologic sections were developed by incorporating LIDAR imagery, existing map sources, and drillers' logs from 110 inventoried wells. The hydrogeologic framework outlined in the study will help characterize the occurrence of ground water in the unconsolidated glacial deposits and how it interacts with the surface-water system. Water levels measured throughout the study show that the altitude of the water table parallels the surface topography and ranges from 0 to 400 feet above the North American Vertical Datum of 1988 across the basin, and seasonal variations in precipitation due to natural cycles generally are on the order of 2 to 3 feet. Synoptic stream-discharge measurements and instream mini-piezometers and piezometers with nested temperature sensors provided additional data to refine the positions of gaining and losing reaches and delineate seasonal variations. Chimacum Creek generally gains water from the shallow ground-water system, except near the community of Chimacum where localized losses occur. In the lower portions of Chimacum Creek, gaining conditions dominate in the summer when creek stages are low and ground-water levels are high, and losing conditions dominate in the winter when creek stages are high relative to ground-water levels. In the Quilcene Bay area, three drainage basins were studied specifically to assess surface water/ground water interactions. The upper reaches of Tarboo Creek generally gain water from the shallow ground-water system

Stimulating shale gas development in China: A comparison with the US experience

International Nuclear Information System (INIS)

Tian, Lei; Wang, Zhongmin; Krupnick, Alan; Liu, Xiaoli

2014-01-01

In this paper, we use the US shale gas experience to shed light on how China might overcome the innovation problem inherent in exploring and developing shale gas plays with complex geology. We separate shale gas development into two stages, an innovation stage and a scaling-up stage, with the first presenting a much bigger challenge than the latter. Our analysis suggests that China's national oil companies offer the best hope for overcoming the innovation problem. China's policy of opening shale gas development to new entrants is a market-oriented reform that can be justified on various grounds, but the new entrants will not play a major role in overcoming the innovation problem even though they may help scale up production later on. - Highlights: • We separate shale gas development into an innovation stage and a scaling up stage. • We use the US experience to elucidate how China may solve the innovation problem. • China has to rely on its national oil companies to solve the innovation problem. • Opening shale gas development to new entrants can be justified on several grounds. • New entrants will not help overcome the innovation problem

The Generality of Adult Development Stages and Transformations: Comparing Meaning-making and Logical Reasoning

Directory of Open Access Journals (Sweden)

Tom Hagström

2015-09-01

Full Text Available Human development theories differ in “context sensitivity,” covering those stressing development stages and those stressing continuously progressing changes. The former theories differ in whether, how and why the stages are regarded as being generalized across domains, i.e. their generality claims. Piaget’s developmental stage theory of logical complexity of children and adolescents fulfill “strong” such claims, including fixed stage sequentiality of increasing complexity levels and higher stage structures integrating earlier ones. His theory has inspired a number of adult development stage theories with varying generality claims. These provide suggestions of stages and stage transitions reaching beyond “pure” cognition, integrating more of e.g. emotional, value and moral dimensions. From a neo-Piagetian perspective, core generality aspects seem to concern on the one hand logical reasoning and on the other hand meaning-making. This raises questions of how these aspects are related to each other in terms of stage structures and transformations. The aim of the article is to discern general features in adult development stage structures and transitions, in terms of logical reasoning and meaning making. This is carried out by a “thought experiment” interrelating two theories that differ in these respects but that are both based on Piaget’s theory, namely Robert Kegan’s constructive developmental Subject-Object Theory (SOT and Michael Common´s behaviouristic Model of Hierarchical Complexity (MHC. This comparing approach concerns the 3rd, 4th and 5th order of consciousness as well as transitions between these according to SOT, and order 9 to 12 and corresponding transitions according to MHC. The thought experiment indicates that the generality claims of both models can be argued for without one of them necessarily being subordinated to the other one. Both theories are interpreted as differing but partly overlapping structures of

A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development.

Directory of Open Access Journals (Sweden)

Olivier Silvie

2008-06-01

Full Text Available Plasmodium sporozoites invade host hepatocytes and develop as liver stages (LS before the onset of erythrocytic infection and malaria symptoms. LS are clinically silent, and constitute ideal targets for causal prophylactic drugs and vaccines. The molecular and cellular mechanisms underlying LS development remain poorly characterized. Here we describe a conserved Plasmodium asparagine-rich protein that is specifically expressed in sporozoites and liver stages. Gene disruption in Plasmodium berghei results in complete loss of sporozoite infectivity to rodents, due to early developmental arrest after invasion of hepatocytes. Mutant sporozoites productively invade host cells by forming a parasitophorous vacuole (PV, but subsequent remodelling of the membrane of the PV (PVM is impaired as a consequence of dramatic down-regulation of genes encoding PVM-resident proteins. These early arrested mutants confer only limited protective immunity in immunized animals. Our results demonstrate the role of an asparagine-rich protein as a key regulator of Plasmodium sporozoite gene expression and LS development, and suggest a requirement of partial LS maturation to induce optimal protective immune responses against malaria pre-erythrocytic stages. These findings have important implications for the development of genetically attenuated parasites as a vaccine approach.

Ground-water flow and ground- and surface-water interaction at the Weldon Spring quarry, St. Charles County, Missouri

International Nuclear Information System (INIS)

Imes, J.L.; Kleeschulte, M.J.

1997-01-01

Ground-water-level measurements to support remedial actions were made in 37 piezometers and 19 monitoring wells during a 19-month period to assess the potential for ground-water flow from an abandoned quarry to the nearby St. Charles County well field, which withdraws water from the base of the alluvial aquifer. From 1957 to 1966, low-level radioactive waste products from the Weldon Spring chemical plant were placed in the quarry a few hundred feet north of the Missouri River alluvial plain. Uranium-based contaminants subsequently were detected in alluvial ground water south of the quarry. During all but flood conditions, lateral ground-water flow in the bedrock from the quarry, as interpreted from water-table maps, generally is southwest toward Little Femme Osage Creek or south into the alluvial aquifer. After entering the alluvial aquifer, the ground water flows southeast to east toward a ground-water depression presumably produced by pumping at the St. Charles County well field. The depression position varies depending on the Missouri River stage and probably the number and location of active wells in the St. Charles County well field

Towards Autonomous Agriculture: Automatic Ground Detection Using Trinocular Stereovision

Directory of Open Access Journals (Sweden)

Annalisa Milella

2012-09-01

Full Text Available Autonomous driving is a challenging problem, particularly when the domain is unstructured, as in an outdoor agricultural setting. Thus, advanced perception systems are primarily required to sense and understand the surrounding environment recognizing artificial and natural structures, topology, vegetation and paths. In this paper, a self-learning framework is proposed to automatically train a ground classifier for scene interpretation and autonomous navigation based on multi-baseline stereovision. The use of rich 3D data is emphasized where the sensor output includes range and color information of the surrounding environment. Two distinct classifiers are presented, one based on geometric data that can detect the broad class of ground and one based on color data that can further segment ground into subclasses. The geometry-based classifier features two main stages: an adaptive training stage and a classification stage. During the training stage, the system automatically learns to associate geometric appearance of 3D stereo-generated data with class labels. Then, it makes predictions based on past observations. It serves as well to provide training labels to the color-based classifier. Once trained, the color-based classifier is able to recognize similar terrain classes in stereo imagery. The system is continuously updated online using the latest stereo readings, thus making it feasible for long range and long duration navigation, over changing environments. Experimental results, obtained with a tractor test platform operating in a rural environment, are presented to validate this approach, showing an average classification precision and recall of 91.0% and 77.3%, respectively.

Towards re-use of knowledge in the concept stage of development

NARCIS (Netherlands)

Smallenburg, K.; Halman, J.I.M.; Mal, van H.H.

1996-01-01

A framework for specifying the intended result of a product development project is introduced in the paper. This framework has been developed for the concept stage and facilitates the establishment and re-use of acquired knowledge. In this way, core capabilities naturally grow stronger with each

Figure-ground segregation can rely on differences in motion direction.

Science.gov (United States)

Kandil, Farid I; Fahle, Manfred

2004-12-01

If the elements within a figure move synchronously while those in the surround move at a different time, the figure is easily segregated from the surround and thus perceived. Lee and Blake (1999) [Visual form created solely from temporal structure. Science, 284, 1165-1168] demonstrated that this figure-ground separation may be based not only on time differences between motion onsets, but also on the differences between reversals of motion direction. However, Farid and Adelson (2001) [Synchrony does not promote grouping in temporally structured displays. Nature Neuroscience, 4, 875-876] argued that figure-ground segregation in the motion-reversal experiment might have been based on a contrast artefact and concluded that (a)synchrony as such was 'not responsible for the perception of form in these or earlier displays'. Here, we present experiments that avoid contrast artefacts but still produce figure-ground segregation based on purely temporal cues. Our results show that subjects can segregate figure from ground even though being unable to use motion reversals as such. Subjects detect the figure when either (i) motion stops (leading to contrast artefacts), or (ii) motion directions differ between figure and ground. Segregation requires minimum delays of about 15 ms. We argue that whatever the underlying cues and mechanisms, a second stage beyond motion detection is required to globally compare the outputs of local motion detectors and to segregate figure from ground. Since analogous changes take place in both figure and ground in rapid succession, this second stage has to detect the asynchrony with high temporal precision.

Optimized ex-ovo culturing of chick embryos to advanced stages of development.

Science.gov (United States)

Cloney, Kellie; Franz-Odendaal, Tamara Anne

2015-01-24

Research in anatomy, embryology, and developmental biology has largely relied on the use of model organisms. In order to study development in live embryos model organisms, such as the chicken, are often used. The chicken is an excellent model organism due to its low cost and minimal maintenance, however they present observational challenges because they are enclosed in an opaque eggshell. In order to properly view the embryo as it develops, the shell must be windowed or removed. Both windowing and ex ovo techniques have been developed to assist researchers in the study of embryonic development. However, each of the methods has limitations and challenges. Here, we present a simple, optimized ex ovo culture technique for chicken embryos that enables the observation of embryonic development from stage HH 19 into late stages of development (HH 40), when many organs have developed. This technique is easy to adopt in both undergraduate classes and more advanced research laboratories where embryo manipulations are conducted.

Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods. Stages 14 and 15

International Nuclear Information System (INIS)

Pazsit, Imre; Wihlstrand, Gustav; Tambouratzis, Tatiana; Jonsson, Anders; Dahl, Berit

2009-12-01

This report constitutes Stages 14 and 15 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. Stage 14 was a full one-year project, whereas Stage 15 consisted of a half-year project. The program executed in Stages 14 and 15 consists of the following three parts: - Study of criticality, neutron kinetics and neutron noise in molten salt reactors (MSR) (Stages 14 and 15); - An overview and introduction to fuzzy logics (Stage 14), and an application to two-phase flow identification (Stage 15) - Preparations for and execution of an IAEA-ICTP workshop on Neutron fluctuations, reactor noise and their applications in nuclear reactors (Stage 14)

Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods. Stages 14 and 15

Energy Technology Data Exchange (ETDEWEB)

Pazsit, Imre; Wihlstrand, Gustav; Tambouratzis, Tatiana; Jonsson, Anders; Dahl, Berit (Chalmers Univ. of Technology, Dept. of Nuclear Engineering, SE-412 96 Goeteborg (Sweden))

2009-12-15

This report constitutes Stages 14 and 15 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. Stage 14 was a full one-year project, whereas Stage 15 consisted of a half-year project. The program executed in Stages 14 and 15 consists of the following three parts: - Study of criticality, neutron kinetics and neutron noise in molten salt reactors (MSR) (Stages 14 and 15); - An overview and introduction to fuzzy logics (Stage 14), and an application to two-phase flow identification (Stage 15) - Preparations for and execution of an IAEA-ICTP workshop on Neutron fluctuations, reactor noise and their applications in nuclear reactors (Stage 14)

Investigation of historical evolution stages of the term "pedagogical innovation" in modern scientific discourse

Directory of Open Access Journals (Sweden)

Світлана Миколаївна Ефендієва

2016-12-01

Full Text Available The article describes the basic concepts of innovation. The formation of pedagogical innovations was analyzed and factors of effective management of innovative development were theoretically grounded. The essence of the concepts of scientific and pedagogical discourse was highlighted. The historical stages of the evolution of the term «pedagogical innovation» were investigated. The main draft laws about innovation activity in education were characterized

New, but slow – technical newness challenges late stage development speed

DEFF Research Database (Denmark)

Smed, Marie; Salomo, Søren; Getz, Kenneth A.

2014-01-01

The down-stream processes where new product prospects undergo pilot testing and adjustments before market launch can have significant impact on development speed. Previous literature has primarily pointed to firm traits as influential factors to speed. However, product specific measures such as t......The down-stream processes where new product prospects undergo pilot testing and adjustments before market launch can have significant impact on development speed. Previous literature has primarily pointed to firm traits as influential factors to speed. However, product specific measures...... such as technical innovativeness may be a critical factor when going through the crucial late stages of development. We have limited knowledge of the relation between product newness and the speed of NPD, and how this may be related to firm size and partnering strategies during development. Combining product traits...... with firm resources relevant to late stage development speed can enrich our understanding of time-tomarket in the aim of improving this crucial measure of NPD. The research model is tested on a dataset of all new drug developments approved for the US market 2000-2010. The results show that newness...

STATE CONTROL OF THE REPUBLIC OF BELARUS: INITIAL STAGE OF ORGANIZATION AND DEVELOPMENT

Directory of Open Access Journals (Sweden)

V. A. Sakovich

2013-01-01

Full Text Available  The paper considers  the initial stage of organization and development of the first State control organ of the independent Belarus – Control Chamber of the Republic of Belarus on the basis of scientific grounds of control theory of economic systems. Scientific and methodologically considered organizational and coordination approaches to the activity of the Control Chamber have promoted to  higher intensity and efficiency of financial and economic control in the initial period of the activity of new control organ and  the activity of all control organs of the Republic has taken systemized and perfectly oriented character. Such approaches have made it possible to stabilize macro-economic situation in the Republic and strengthen its economic security. The Control Chamber through highly-qualified personal, created and practically introduced methodological principles of control activity, international cooperation experience and finally high efficiency of practical control activity has made its historical contribution in formation of fundamentals of  the State Control in Belarus.13th of March 1992 is the day when the Law “About Control Chamber of the Republic of Belarus” has been enacted by the Supreme Council of the Republic of Belarus and this day is to considered as the Day of State Control foundation in the Republic of Belarus.  

Approach to developing a ground-motion design basis for facilities important to safety at Yucca Mountain

International Nuclear Information System (INIS)

King, J.L.

1990-01-01

This paper discusses a methodology for developing a ground-motion design basis for prospective facilities at Yucca Mountain that are important to safety. The methodology utilizes a guasi-deterministic construct called the 10,000-year cumulative-slip earthquake that is designed to provide a conservative, robust, and reproducible estimate of ground motion that has a one-in-ten chance of occurring during the preclosure period. This estimate is intended to define a ground-motion level for which the seismic design would ensure minimal disruption to operations engineering analyses to ensure safe performance are included

Location and cellular stages of NK cell development

Science.gov (United States)

Yu, Jianhua; Freud, Aharon G.; Caligiuri, Michael A

2013-01-01

The identification of distinct tissue-specific natural killer (NK) cell populations that apparently mature from local precursor populations has brought new insight into the diversity and developmental regulation of this important lymphoid subset. NK cells provide a necessary link between the early (innate) and late (adaptive) immune responses to infection. Gaining a better understanding of the processes that govern NK cell development should allow us to better harness NK cell functions in multiple clinical settings as well as to gain further insight into how these cells undergo malignant transformation. In this review, we summarize recent advances in understanding sites and cellular stages of NK cell development in humans and mice. PMID:24055329

SPHERES: From Ground Development to Operations on ISS

Science.gov (United States)

Katterhagen, A.

2015-01-01

SPHERES (Synchronized Position Hold Engage and Reorient Experimental Satellites) is an internal International Space Station (ISS) Facility that supports multiple investigations for the development of multi-spacecraft and robotic control algorithms. The SPHERES Facility on ISS is managed and operated by the SPHERES National Lab Facility at NASA Ames Research Center (ARC) at Moffett Field California. The SPHERES Facility on ISS consists of three self-contained eight-inch diameter free-floating satellites which perform the various flight algorithms and serve as a platform to support the integration of experimental hardware. To help make science a reality on the ISS, the SPHERES ARC team supports a Guest Scientist Program (GSP). This program allows anyone with new science the possibility to interface with the SPHERES team and hardware. In addition to highlighting the available SPHERES hardware on ISS and on the ground, this presentation will also highlight ground support, facilities, and resources available to guest researchers. Investigations on the ISS evolve through four main phases: Strategic, Tactical, Operations, and Post Operations. The Strategic Phase encompasses early planning beginning with initial contact by the Principle Investigator (PI) and the SPHERES program who may work with the PI to assess what assistance the PI may need. Once the basic parameters are understood, the investigation moves to the Tactical Phase which involves more detailed planning, development, and testing. Depending on the nature of the investigation, the tactical phase may be split into the Lab Tactical Phase or the ISS Tactical Phase due to the difference in requirements for the two destinations. The Operations Phase is when the actual science is performed; this can be either in the lab, or on the ISS. The Post Operations Phase encompasses data analysis and distribution, and generation of summary status and reports. The SPHERES Operations and Engineering teams at ARC is composed of

Integrating and Analyzing Psychosocial and Stage Theories To Challenge the Development of the Injured Collegiate Athlete.

Science.gov (United States)

Harris, Laura L.

2003-01-01

Integrated a psychosocial developmental theory (the Kubler-Ross Stage Theory) and a psychological stage theory (the Ross Stage Theory) and a psychological stage theory (the Chickering and Reisser psychosocial and developmental theory) for challenging injured collegiate student-athletes' personal development. A search of online databases from…

Staged Repository Development Programmes

International Nuclear Information System (INIS)

Isaacs, T

2003-01-01

Programs to manage and ultimately dispose of high-level radioactive wastes are unique from scientific and technological as well as socio-political aspects. From a scientific and technological perspective, high-level radioactive wastes remain potentially hazardous for geological time periods-many millennia-and scientific and technological programs must be put in place that result in a system that provides high confidence that the wastes will be isolated from the accessible environment for these many thousands of years. Of course, ''proof'' in the classical sense is not possible at the outset, since the performance of the system can only be known with assurance, if ever, after the waste has been emplaced for those geological time periods. Adding to this challenge, many uncertainties exist in both the natural and engineered systems that are intended to isolate the wastes, and some of the uncertainties will remain regardless of the time and expense in attempting to characterize the system and assess its performance. What was perhaps underappreciated in the early days of waste management and repository program development were the unique and intense reactions that the institutional, political, and public bodies would have to repository program development, particularly in programs attempting to identify and then select sites for characterization, design, licensing, and ultimate development. Reactions in most nations were strong, focused, unrelenting, and often successful in hindering, derailing, and even stopping national repository programs. The reasons for such reactions and the measures to successfully respond to them are still evolving and continue to be the focus of many national program and political leaders. Adaptive Staging suggests an approach to repository program development that reflects the unique challenges associated with the disposal of high-level radioactive waste. The step-wise, incremental, learn-as-you-go approach is intended to maximize the

Review Essay: A Journey through Grounded Theory

Directory of Open Access Journals (Sweden)

Paula Krüger

2007-01-01

Full Text Available In "Constructing Grounded Theory", Kathy CHARMAZ guides the reader through the research process. Starting with a look back at the history of grounded theory, she explains how to gather rich data, code it, write memos, and compose the first draft. Through various examples from her own research CHARMAZ provides the reader not only with a theoretical description of how to construct a grounded theory but also with a way of seeing how new questions emerge from the data and new theory is built from it. She highlights central concepts, definitions, and useful questions, and offers the reader flexible guidelines to design and conduct a research project. Because of this, the book will be very useful for novices as well as for experts and (PhD- students in the late stages of their theses; it is a must-have for everyone who works with/on (constructivist grounded theory. URN: urn:nbn:de:0114-fqs0701256

Saturn V First Stage Leaves the Dynamic Test Stand

Science.gov (United States)

1967-01-01

This photo shows the Saturn V first stage being lowered to the ground following a successful test to determine the effects of continual vibrations simulating the effects of an actual launch. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

A staging scheme for the development of the scuttle fly Megaselia abdita.

Directory of Open Access Journals (Sweden)

Karl R Wotton

Full Text Available Model organisms, such as Drosophila melanogaster, provide powerful experimental tools for the study of development. However, approaches using model systems need to be complemented by comparative studies for us to gain a deeper understanding of the functional properties and evolution of developmental processes. New model organisms need to be established to enable such comparative work. The establishment of new model system requires a detailed description of its life cycle and development. The resulting staging scheme is essential for providing morphological context for molecular studies, and allows us to homologise developmental processes between species. In this paper, we provide a staging scheme and morphological characterisation of the life cycle for an emerging non-drosophilid dipteran model system: the scuttle fly Megaselia abdita. We pay particular attention to early embryogenesis (cleavage and blastoderm stages up to gastrulation, the formation and retraction of extraembryonic tissues, and the determination and formation of germ (pole cells. Despite the large evolutionary distance between the two species (approximately 150 million years, we find that M. abdita development is remarkably similar to D. melanogaster in terms of developmental landmarks and their relative timing.

Fish early life stage: Developing AOPs to support targeted reduction and replacement

Science.gov (United States)

There is an interest in developing alternatives to the fish early-life stage (FELS) test (OECD test guideline 210), for predicting adverse chronic toxicity outcomes (e.g., impacts on growth and survival). Development and characterization of adverse outcome pathways (AOPs) related...

Gestalt and Figure-Ground: Reframing Graduate Attribute Conversations between Educational Developers and Academics

Science.gov (United States)

Knewstubb, Bernadette; Ruth, Alison

2015-01-01

Academics implementing graduate attributes, and the educational developers who support those academics, may experience graduate attributes and disciplinary knowledge and skills as unrelated dimensions of curriculum. Gestalt conceptions of curriculum, together with a figure-ground understanding of the relationship between disciplinary understanding…

Development and use of interactive displays in real-time ground support research facilities

Science.gov (United States)

Rhea, Donald C.; Hammons, Kvin R.; Malone, Jacqueline C.; Nesel, Michael C.

1989-01-01

The NASA Western Aeronautical Test Range (WATR) is one of the world's most advanced aeronautical research flight test support facilities. A variety of advanced and often unique real-time interactive displays has been developed for use in the mission control centers (MCC) to support research flight and ground testing. These dispalys consist of applications operating on systems described as real-time interactive graphics super workstations and real-time interactive PC/AT compatible workstations. This paper reviews these two types of workstations and the specific applications operating on each display system. The applications provide examples that demonstrate overall system capability applicable for use in other ground-based real-time research/test facilities.

Why Are There Developmental Stages in Language Learning? A Developmental Robotics Model of Language Development.

Science.gov (United States)

Morse, Anthony F; Cangelosi, Angelo

2017-02-01

Most theories of learning would predict a gradual acquisition and refinement of skills as learning progresses, and while some highlight exponential growth, this fails to explain why natural cognitive development typically progresses in stages. Models that do span multiple developmental stages typically have parameters to "switch" between stages. We argue that by taking an embodied view, the interaction between learning mechanisms, the resulting behavior of the agent, and the opportunities for learning that the environment provides can account for the stage-wise development of cognitive abilities. We summarize work relevant to this hypothesis and suggest two simple mechanisms that account for some developmental transitions: neural readiness focuses on changes in the neural substrate resulting from ongoing learning, and perceptual readiness focuses on the perceptual requirements for learning new tasks. Previous work has demonstrated these mechanisms in replications of a wide variety of infant language experiments, spanning multiple developmental stages. Here we piece this work together as a single model of ongoing learning with no parameter changes at all. The model, an instance of the Epigenetic Robotics Architecture (Morse et al 2010) embodied on the iCub humanoid robot, exhibits ongoing multi-stage development while learning pre-linguistic and then basic language skills. Copyright © 2016 Cognitive Science Society, Inc.

Spheres: from Ground Development to ISS Operations

Science.gov (United States)

Katterhagen, A.

2016-01-01

SPHERES (Synchronized Position Hold Engage and Reorient Experimental Satellites) is an internal International Space Station (ISS) Facility that supports multiple investigations for the development of multi-spacecraft and robotic control algorithms. The SPHERES National Lab Facility aboard ISS is managed and operated by NASA Ames Research Center (ARC) at Moffett Field California. The SPHERES Facility on ISS consists of three self-contained eight-inch diameter free-floating satellites which perform the various flight algorithms and serve as a platform to support the integration of experimental hardware. SPHERES has served to mature the adaptability of control algorithms of future formation flight missions in microgravity (6 DOF (Degrees of Freedom) / long duration microgravity), demonstrate key close-proximity formation flight and rendezvous and docking maneuvers, understand fault diagnosis and recovery, improve the field of human telerobotic operation and control, and lessons learned on ISS have significant impact on ground robotics, mapping, localization, and sensing in three-dimensions - among several other areas of study.

Electrochemical stabilization of clayey ground

Science.gov (United States)

Rzhanitzin, B.A.; Sokoloff, V.P.

1947-01-01

Recently developed new methods of stabilization of weak grounds (e.g. the silicate treatment) are based on injection of chemical solutions into the ground. Such methods are applicable accordingly only to the kinds of ground that have the coefficient of filtration higher than 2 meters per 24 hours and permit penetration of the chemical solutions under pressure. This limit, however, as it is shown by our experience in construction, excludes a numerous and an important class of grounds, stabilization of which is indispensable in many instances. For example, digging of trenches and pits in clayey, silty, or sandy ground shows that all these types act like typical "floaters" (sluds? -S) in the presence of the ground water pressure. There were several instances in the canalization of the city of Moskow where the laying of trenches below the ground water level has led to extreme difficulties with clayey and silty ground. Similar examples could be cited in mining, engineering hydrology, and railroad construction. For these reasons, the development of methods of stabilizing such difficult types of ground has become an urgent problem of our day. In 1936, the author began his investigations, at the ground Stabilization Laboratory of VODGEO Institute, with direct electrical current as the means of stabilization of grounds. Experiments had shown that a large number of clayey types, following passage of direct electrical current, undergoes a transformation of its physico-chemical properties. It was established that the (apparent -S) density of the ground is substantially increased in consequence of the application of direct electrical current. The ground loses also its capacity to swell and to soften in water. Later, after a more detailed study of the physico-chemical mechanism of the electrical stabilization, it became possible to develop the method so as to make it applicable to sandy and silty as well as to clayey ground. By this time (1941, S.), the method has already been

Ground Systems Development and Operations (GSDO) Education 101: Exploration Begins Here [Grades 9-12

Science.gov (United States)

Hill, Trudy

2012-01-01

Presentation to inform the non-NASA general public and school children of ground systems development and operations activities at Kennedy Space Center, particularly on what GSDO is and does, in a high level overview.

Anther development stage and gamma radiation effects on tomato anther-derived callus formation

International Nuclear Information System (INIS)

Brasileiro, Ana Christina R.; Willadino, Lilia; Guerra, Marcelo; Colaco, Waldeciro; Meunier, Isabelle; Camara, Terezinha R.

1999-01-01

Two experiments were carried (I) to determine tomato anther development stage influence on callus production; and (II) to investigate gamma radiation effects on anther culture. In the first experiment, anthers of a tomato hybrid (IPA 5 x Rotam 4-F 1 ) were grown on three media. Although calli were induced at all stages of anther development, varying from prophase I to mono nucleate microspore, callus frequency decreased as anther development progressed and calli induction were not significantly affected by all media tested. Anthers containing prophase I meiocytes produced the highest calli frequency. Anther and flower bud length both were significantly correlated with anther development stage. In the second experiment, seed and floral buds of tomato hybrids IPA 5 x Rotam 4 (F 2 ), IPA 6 x Rotam 4 (F 2 ) and IPA 8 x 217.1 (F 2 ) were submitted to gamma-ray and anthers were plated on two media described by Gresshoff and Doy (1972) supplemented with 2.0 mg L -1 NAA + 5.0 mg L -1 KIN and 2.0 mg L -1 NAA + 1.0 mg L -1 KIN. No significant differences for genotype and dosage testes were found for calli formation. (author)

Final Stage Development of Reactor Console Simulator

International Nuclear Information System (INIS)

Mohamad Idris Taib; Ridzuan Abdul Mutalib; Zareen Khan Abdul Jalil Khan; Mohd Khairulezwan Abdul Manan; Mohd Sabri Minhat; Nurfarhana Ayuni Joha

2013-01-01

The Reactor Console Simulator PUSPATI TRIGA Reactor was developed since end of 2011 and now in the final stage of development. It is will be an interactive tool for operator training and teaching of PUSPATI TRIGA Reactor. Behavior and characteristic for reactor console and reactor itself can be evaluated and understand. This Simulator will be used as complement for actual present reactor console. Implementation of human system interface (HSI) is using computer screens, keyboard and mouse. Multiple screens are used to match the physical of present reactor console. LabVIEW software are using for user interface and mathematical calculation. Polynomial equation based on control rods calibration data as well as operation parameters record was used to calculate and estimated reactor console parameters. The capabilities in user interface, reactor physics and thermal-hydraulics can be expanded and explored to simulation as well as modeling for New Reactor Console, Research Reactor and Nuclear Power Plant. (author)

Infectivity and development of X-irradiated third-stage larvae of Angiostrongylus cantonensis in rats

International Nuclear Information System (INIS)

Fujiu, Yoshinori

1989-01-01

Angiostrongylus cantonensis third-stage larvae were exposed to less than 10Krad of X-radiation and then given orally to white rats to examine the effects of X-radiation on infectivity and development of the irradiated third-stage larvae and on fecundity of adults developing from the irradiated third-stage larvae. The deleterious effects of X-radiation were observed at relatively lower dosage in the above three parameters. A degree in susceptibility on X-radiation was shown to be radiation-dose-dependent. Comparing to the irradiation of larvae in vitro, the irradiation of larvae in snails caused less deleterious effects at the same dose of X-irradiation. Application of X-radiation to food hygiene was also discussed. (author)

Three-Stage InP Submillimeter-Wave MMIC Amplifier

Science.gov (United States)

Pukala, David; Samoska, Lorene; Man, King; Gaier, Todd; Deal, William; Lai, Richard; Mei, Gerry; Makishi, Stella

2008-01-01

A submillimeter-wave monolithic integrated- circuit (S-MMIC) amplifier has been designed and fabricated using an indium phosphide (InP) 35-nm gate-length high electron mobility transistor (HEMT) device, developed at Northrop Grumman Corporation. The HEMT device employs two fingers each 15 micrometers wide. The HEMT wafers are grown by molecular beam epitaxy (MBE) and make use of a pseudomorphic In0.75Ga0.25As channel, a silicon delta-doping layer as the electron supply, an In0.52Al0.48As buffer layer, and an InP substrate. The three-stage design uses coplanar waveguide topology with a very narrow ground-to-ground spacing of 14 micrometers. Quarter-wave matching transmission lines, on-chip metal-insulator-metal shunt capacitors, series thin-film resistors, and matching stubs were used in the design. Series resistors in the shunt branch arm provide the basic circuit stabilization. The S-MMIC amplifier was measured for S-parameters and found to be centered at 320 GHz with 13-15-dB gain from 300-345 GHz. This chip was developed as part of the DARPA Submillimeter Wave Imaging Focal Plane Technology (SWIFT) program (see figure). Submillimeter-wave amplifiers could enable more sensitive receivers for earth science, planetary remote sensing, and astrophysics telescopes, particularly in radio astronomy, both from the ground and in space. A small atmospheric window at 340 GHz exists and could enable ground-based observations. However, the submillimeter-wave regime (above 300 GHz) is best used for space telescopes as Earth s atmosphere attenuates most of the signal through water and oxygen absorption. Future radio telescopes could make use of S-MMIC amplifiers for wideband, low noise, instantaneous frequency coverage, particularly in the case of heterodyne array receivers.

The Development of Altruism with Special Reference to Human Relationships: A 10-Stage Theory

Directory of Open Access Journals (Sweden)

Hing Keung Ma

2017-10-01

Full Text Available All human relationships involve some form of cost and benefit and altruism forms the foundation upon which human relationships are built. In this paper, a taxonomy of human relationships in terms of altruism was constructed. In the proposed taxonomy, human relationships are categorized into three major groups: primary group, secondary group, and tertiary group. The primary group consists of members that are very closely related to each other either by genetic relatedness (e.g., parents, siblings, and cousins or social relatedness (e.g., mate and close friends or both. The secondary group consists of members that are socially related but also less closely related with each other (e.g., people of the same political or religious group, teachers, mentors, acquaintances, neighbors, working colleagues, and strangers. Lastly, the tertiary group consists of members of other species. A 10-stage theory of altruism with special reference to human relationships is proposed. The affective, cognitive, and relationship aspects of each stage are delineated in details. There are two developmental principles of altruism. The first principle states that the development of altruism follows the 10-stage theory and moves from Stage 1: Egoism toward the higher stages of altruism slowly. The second developmental principle states that the taxonomy of human relationships is valid at any stage of altruism development. In other words, people at any stage of altruism are more altruistic toward their kin and mate, and then close friends, extended family members, and so on. They are least altruistic toward enemies and members of non-human species. In summary, the proposed developmental principle of altruism and human relationships is logical and robust. It is formulated based on the major developmental and social psychological theories. The theory has the potential in providing a useful framework for future studies on the development and evolution of human relationships.

The Development of Altruism with Special Reference to Human Relationships: A 10-Stage Theory

Science.gov (United States)

Ma, Hing Keung

2017-01-01

All human relationships involve some form of cost and benefit and altruism forms the foundation upon which human relationships are built. In this paper, a taxonomy of human relationships in terms of altruism was constructed. In the proposed taxonomy, human relationships are categorized into three major groups: primary group, secondary group, and tertiary group. The primary group consists of members that are very closely related to each other either by genetic relatedness (e.g., parents, siblings, and cousins) or social relatedness (e.g., mate and close friends) or both. The secondary group consists of members that are socially related but also less closely related with each other (e.g., people of the same political or religious group, teachers, mentors, acquaintances, neighbors, working colleagues, and strangers). Lastly, the tertiary group consists of members of other species. A 10-stage theory of altruism with special reference to human relationships is proposed. The affective, cognitive, and relationship aspects of each stage are delineated in details. There are two developmental principles of altruism. The first principle states that the development of altruism follows the 10-stage theory and moves from Stage 1: Egoism toward the higher stages of altruism slowly. The second developmental principle states that the taxonomy of human relationships is valid at any stage of altruism development. In other words, people at any stage of altruism are more altruistic toward their kin and mate, and then close friends, extended family members, and so on. They are least altruistic toward enemies and members of non-human species. In summary, the proposed developmental principle of altruism and human relationships is logical and robust. It is formulated based on the major developmental and social psychological theories. The theory has the potential in providing a useful framework for future studies on the development and evolution of human relationships. PMID:29085818

The Development of Altruism with Special Reference to Human Relationships: A 10-Stage Theory.

Science.gov (United States)

Ma, Hing Keung

2017-01-01

All human relationships involve some form of cost and benefit and altruism forms the foundation upon which human relationships are built. In this paper, a taxonomy of human relationships in terms of altruism was constructed. In the proposed taxonomy, human relationships are categorized into three major groups: primary group, secondary group, and tertiary group. The primary group consists of members that are very closely related to each other either by genetic relatedness (e.g., parents, siblings, and cousins) or social relatedness (e.g., mate and close friends) or both. The secondary group consists of members that are socially related but also less closely related with each other (e.g., people of the same political or religious group, teachers, mentors, acquaintances, neighbors, working colleagues, and strangers). Lastly, the tertiary group consists of members of other species. A 10-stage theory of altruism with special reference to human relationships is proposed. The affective, cognitive, and relationship aspects of each stage are delineated in details. There are two developmental principles of altruism. The first principle states that the development of altruism follows the 10-stage theory and moves from Stage 1: Egoism toward the higher stages of altruism slowly. The second developmental principle states that the taxonomy of human relationships is valid at any stage of altruism development. In other words, people at any stage of altruism are more altruistic toward their kin and mate, and then close friends, extended family members, and so on. They are least altruistic toward enemies and members of non-human species. In summary, the proposed developmental principle of altruism and human relationships is logical and robust. It is formulated based on the major developmental and social psychological theories. The theory has the potential in providing a useful framework for future studies on the development and evolution of human relationships.

Development of 52 inches last stage blade for steam turbines

International Nuclear Information System (INIS)

Suzuki, Atsuhide; Hisa, Shoichi; Nagao, Shinichiro; Ogata, Hisao

1986-01-01

The last stage blades of steam turbines are the important component controlling the power output and performance of plants. In order to realize a unit of large capacity and high efficiency, the proper exhaust area and the last stage blades having good performance are indispensable. Toshiba Corp. has completed the development of the 52 inch last stage blades for 1500 and 1800 rpm steam turbines. The 52 inch last stage blades are the longest in the world, which have the annular exhaust area nearly 1.5 times as much as that of 41 inch blades used for 1100 MW, 1500 rpm turbines in nuclear power stations. By adopting these 52 inch blades, the large capacity nuclear power plants up to 1800 MW can be economically constructed, the rate of heat consumption of 1350 MW plants is improved by 3 ∼ 4 % as compared with 41 inch blades, and in the plants up to 1100 MW, LP turbines can be reduced from three sets to two. The features of 52 inch blades, the flow pattern and blade form design, the structural strength analysis and the erosion withstanding property, and the verification by the rotation test of the actual blades, the performance test using a test turbine, the vibration analysis of the actually loaded blades and the analysis of wet steam behavior are reported. (Kako, I.)

A four stage approach for ontology-based health information system design.

Science.gov (United States)

Kuziemsky, Craig E; Lau, Francis

2010-11-01

To describe and illustrate a four stage methodological approach to capture user knowledge in a biomedical domain area, use that knowledge to design an ontology, and then implement and evaluate the ontology as a health information system (HIS). A hybrid participatory design-grounded theory (GT-PD) method was used to obtain data and code them for ontology development. Prototyping was used to implement the ontology as a computer-based tool. Usability testing evaluated the computer-based tool. An empirically derived domain ontology and set of three problem-solving approaches were developed as a formalized model of the concepts and categories from the GT coding. The ontology and problem-solving approaches were used to design and implement a HIS that tested favorably in usability testing. The four stage approach illustrated in this paper is useful for designing and implementing an ontology as the basis for a HIS. The approach extends existing ontology development methodologies by providing an empirical basis for theory incorporated into ontology design. Copyright © 2010 Elsevier B.V. All rights reserved.

Development of single-well techniques for quantitative ground water studies

International Nuclear Information System (INIS)

Bachmat, Y.; Bugayevsky, M.; Mandel, S.; Behrens, H.; Drost, W.; Klotz, D.; Moser, H.

1984-02-01

The signle-well pulse technique was modified in such manner that the dispersivity of the ground water bearing strata can be derived from the measured results. An outline of the theoretical fundamentals is followed by solutions to apparative problems, i.e. tracer selection (Br-82, colour), set-up of measuring points, etc.. The method was tested in the laboratory and in a test field. Suitable, quick methods of evaluation were developed and the technical equipment was optimized for routine application. The method was tested in wells in Israel. (HP) [de

Periods and stages of the prenatal development of the domestic cat.

Science.gov (United States)

Knospe, C

2002-02-01

Twenty-two stages of the prenatal development of the domestic cat are described for intraspecies comparison in embryological studies. These are assigned to the 15 embryonal periods based on the Nomina Embryologica Veterinaria to make the interspecies comparison possible.

Hydrogeology, simulated ground-water flow, and ground-water quality, Wright-Patterson Air Force Base, Ohio

Science.gov (United States)

Dumouchelle, D.H.; Schalk, C.W.; Rowe, G.L.; De Roche, J.T.

1993-01-01

Ground water is the primary source of water in the Wright-Patterson Air Force Base area. The aquifer consists of glacial sands and gravels that fill a buried bedrock-valley system. Consolidated rocks in the area consist of poorly permeable Ordovician shale of the Richmondian stage, in the upland areas, the Brassfield Limestone of Silurian age. The valleys are filled with glacial sediments of Wisconsinan age consisting of clay-rich tills and coarse-grained outwash deposits. Estimates of hydraulic conductivity of the shales based on results of displacement/recovery tests range from 0.0016 to 12 feet per day; estimates for the glacial sediments range from less than 1 foot per day to more than 1,000 feet per day. Ground water flow from the uplands towards the valleys and the major rivers in the region, the Great Miami and the Mad Rivers. Hydraulic-head data indicate that ground water flows between the bedrock and unconsolidated deposits. Data from a gain/loss study of the Mad River System and hydrographs from nearby wells reveal that the reach of the river next to Wright-Patterson Air Force Base is a ground-water discharge area. A steady-state, three-dimensional ground-water-flow model was developed to simulate ground-water flow in the region. The model contains three layers and encompasses about 100 square miles centered on Wright-Patterson Air Force Base. Ground water enters the modeled area primarily by river leakage and underflow at the model boundary. Ground water exits the modeled area primarily by flow through the valleys at the model boundaries and through production wells. A model sensitivity analysis involving systematic changes in values of hydrologic parameters in the model indicates that the model is most sensitive to decreases in riverbed conductance and vertical conductance between the upper two layers. The analysis also indicates that the contribution of water to the buried-valley aquifer from the bedrock that forms the valley walls is about 2 to 4

Integrating Environmental Decisions into the Product Development Process: Part 1 - The Early Stages

DEFF Research Database (Denmark)

Bhamra, T.; Evans, S.; McAloone, Timothy Charles

1999-01-01

environmental decisions into their product development process which is very unusual in that ecodesign is significantly different for the pre- and post-specification stages of the design process. This paper explains the findings related to the first phase being the very early stages of the product development...... in the UK, Central Europe and the USA are carrying out Ecodesign. The survey also investigated the successes and failures companies had experienced and the lessons they had learnt along the way. From this survey we identified a number of success factors that enabled companies to successfully integrate...... process prior to the specification being finalised. A second paper, considers the findings from the later phases of the product development process....

Development of Earthquake Ground Motion Input for Preclosure Seismic Design and Postclosure Performance Assessment of a Geologic Repository at Yucca Mountain, NV

International Nuclear Information System (INIS)

I. Wong

2004-01-01

This report describes a site-response model and its implementation for developing earthquake ground motion input for preclosure seismic design and postclosure assessment of the proposed geologic repository at Yucca Mountain, Nevada. The model implements a random-vibration theory (RVT), one-dimensional (1D) equivalent-linear approach to calculate site response effects on ground motions. The model provides results in terms of spectral acceleration including peak ground acceleration, peak ground velocity, and dynamically-induced strains as a function of depth. In addition to documenting and validating this model for use in the Yucca Mountain Project, this report also describes the development of model inputs, implementation of the model, its results, and the development of earthquake time history inputs based on the model results. The purpose of the site-response ground motion model is to incorporate the effects on earthquake ground motions of (1) the approximately 300 m of rock above the emplacement levels beneath Yucca Mountain and (2) soil and rock beneath the site of the Surface Facilities Area. A previously performed probabilistic seismic hazard analysis (PSHA) (CRWMS M and O 1998a [DIRS 103731]) estimated ground motions at a reference rock outcrop for the Yucca Mountain site (Point A), but those results do not include these site response effects. Thus, the additional step of applying the site-response ground motion model is required to develop ground motion inputs that are used for preclosure and postclosure purposes

Development of Earthquake Ground Motion Input for Preclosure Seismic Design and Postclosure Performance Assessment of a Geologic Repository at Yucca Mountain, NV

Energy Technology Data Exchange (ETDEWEB)

I. Wong

2004-11-05

This report describes a site-response model and its implementation for developing earthquake ground motion input for preclosure seismic design and postclosure assessment of the proposed geologic repository at Yucca Mountain, Nevada. The model implements a random-vibration theory (RVT), one-dimensional (1D) equivalent-linear approach to calculate site response effects on ground motions. The model provides results in terms of spectral acceleration including peak ground acceleration, peak ground velocity, and dynamically-induced strains as a function of depth. In addition to documenting and validating this model for use in the Yucca Mountain Project, this report also describes the development of model inputs, implementation of the model, its results, and the development of earthquake time history inputs based on the model results. The purpose of the site-response ground motion model is to incorporate the effects on earthquake ground motions of (1) the approximately 300 m of rock above the emplacement levels beneath Yucca Mountain and (2) soil and rock beneath the site of the Surface Facilities Area. A previously performed probabilistic seismic hazard analysis (PSHA) (CRWMS M&O 1998a [DIRS 103731]) estimated ground motions at a reference rock outcrop for the Yucca Mountain site (Point A), but those results do not include these site response effects. Thus, the additional step of applying the site-response ground motion model is required to develop ground motion inputs that are used for preclosure and postclosure purposes.

Software Development and Test Methodology for a Distributed Ground System

Science.gov (United States)

Ritter, George; Guillebeau, Pat; McNair, Ann R. (Technical Monitor)

2002-01-01

The Marshall Space Flight Center's (MSFC) Payload Operations Center (POC) ground system has evolved over a period of about 10 years. During this time the software processes have migrated from more traditional to more contemporary development processes in an effort to minimize unnecessary overhead while maximizing process benefits. The Software processes that have evolved still emphasize requirements capture, software configuration management, design documenting, and making sure the products that have been developed are accountable to initial requirements. This paper will give an overview of how the Software Processes have evolved, highlighting the positives as well as the negatives. In addition, we will mention the COTS tools that have been integrated into the processes and how the COTS have provided value to the project.

Mechanisms important to later stages of streamer system development

Science.gov (United States)

Lehtinen, N. G.; Carlson, B.; Kochkin, P.; Østgaard, N.

2017-12-01

Typical streamer modeling focuses on the propagation of the streamer head and thus neglects processes such as electron detachment, electron energy relaxation, and thermalization of the electron energy distribution. These mechanisms, however, may become important at later stages of streamer system development, in particular following streamer collisions. We present a model of a later-stage streamer system development which includes these processes. A linear analysis suggests that these processes under some conditions can lead to new effects, such as excitation of waves similar to striations in the positive column of a glow discharge. Such instabilities do not occur if these mechanisms are neglected under the same conditions, although previous modeling suggested existence of wave-like phenomena during the streamer propagation [Luque et al, 2016, doi:10.1002/2015JA022234]. In the sea-level pressure air, the obtained striation-like waves may manifest as very high frequency range (>10 MHz) oscillations in plasma parameters and may have been detected in the electrode current and electromagnetic radiation measurements during laboratory spark experiments. We discuss whether the longitudinal electric field in such waves can efficiently transfer energy to charged particles, because such a process may play a role in production of x-rays.

Stages of recovery in early psychosis: Associations with symptoms, function, and narrative development.

Science.gov (United States)

Bourdeau, Geneviève; Lecomte, Tania; Lysaker, Paul H

2015-06-01

This study sought to explore the links between recovery stages, symptoms, function, and narrative development among individuals with a recent onset of psychosis. A qualitative longitudinal study was conducted including quantitative data at baseline. Forty-seven participants were administered the Indiana Psychiatric Illness Interview three times over 9 months and content analysis was performed. Participants also completed the Social Functioning Scale, the Brief Psychiatric Rating Scale--Expanded, the California Verbal Learning Test, and the Trailing Making Test at baseline. Descriptive discriminant analysis was performed. Results suggested that participants were mostly in the first two stages of recovery (moratorium, awareness) and that being in the awareness, rather than moratorium, stage was associated, to a different extent, with richer narrative development, better levels of psychosocial function, less negative and positive symptoms, and more years of education. Furthermore, recovery appeared to be a stable process over the assessment period. Recovery is a complex concept including objective and subjective aspects. In the recovery path of persons recently diagnosed with psychosis, social engagement, narrative development, and occupational functioning seem to be particularly important aspects. This study is a first step, and future research is needed with larger and more diverse participant pools, and assessments conducted over longer periods of time. As greater level of social engagement was the most robust predictor of membership in the awareness versus moratorium stage, treatment of early psychosis should include interventions targeting social relations and social skills. As greater narrative development was the second most robust predictor, enhancing it via psychotherapy could be a pertinent clinical goal. © 2014 The British Psychological Society.

From trust on intimacy: A new inventory for examining erikson's stages of psychosocial development.

Science.gov (United States)

Rosenthal, D A; Gurney, R M; Moore, S M

1981-12-01

A new inventory for examining the first six of Erikson's psychosocial stages is described. The self-report questionnaire, developed in a pilot study of 97 adolescents and tested in a study of 622 adolescents, has 12 items for each subscale. Measures of reliability and validity are reported. It is concluded that the Erikson Psychosocial Stage Inventory (EPSI) is a useful measure for researchers interested in development from early adolescence and in mapping changes as a function of life events.

Three Global Land Cover and Use Stage considering Environmental Condition and Economic Development

Science.gov (United States)

Lee, W. K.; Song, C.; Moon, J.; Ryu, D.

2016-12-01

The Mid-Latitude zone can be broadly defined as part of the hemisphere between around 30° - 60° latitude. This zone is a home to over more than 50% of the world population and encompasses about 36 countries throughout the principal regions which host most of the global problems related to development and poverty. Mid-Latitude region and its ecotone demands in-depth analysis, however, latitudinal approach has not been widely recognized, considering that many of natural resources and environment indicators, as well as social and economic indicators are based on administrative basis or by country and regional boundaries. This study sets the land cover change and use stage based on environmental condition and economic development. Because various land cover and use among the regions, form vegetated parts of East Asia and Mediterranean to deserted parts of Central Asia, the forest area was varied between countries. In addition, some nations such as North Korea, Afghanistan, Pakistan showed decreasing trends in forest area whereas some nations showed increasing trends in forest area. The economic capacity for environmental activities and policies for restoration were different among countries. By adopting the standard from IMF or World Bank, developing and developed counties were classified. Based on the classification, this study suggested the land cover and use stages as degradation, restoration, and sustainability. As the degradation stage, the nations which had decreasing forest area with less environmental restoration capacity based on economic size were selected. As the restoration stage, the nation which had increasing forest area or restoration capacity were selected. In the case of the sustainability, the nation which had enough restoration capacity with increasing forest area or small ratio in forest area decreasing were selected. In reviewing some of the past and current major environmental challenges that regions of Mid-Latitudes are facing, grouping by

Clinical and laboratory characteristics of chronic hepatitis C on the early stages of development

Directory of Open Access Journals (Sweden)

N. S. Zhevnerova

2016-01-01

Full Text Available Aim of the research – to assess the clinical and laboratory parameters in patients with chronic hepatitis C (CHC on the early stages of development and their comparison with the level of galectin3. The study included 78 patients with oligosymptomatic course of the disease and minimal liver fibrosis in the most cases. In the most patients with stages of the disease exceeding 8 years, viral load was over a million copies/ml. In 10 % of patients on the early stages of the disease, changes corresponding to severe liver fibrosis and cirrhosis F3 and F4 were detected. Moderate correlation of ALT activity, viral load and low severity with the duration of the disease was identified. There is a trend towards a higher level of galectin3 in a long course of CHC in comparison with earlier stages of its development, with significantly higher average level of galectin-3 in patients with minimal liver fibrosis (F0–F1 as compared to advanced stages, suggesting its importance in the launching and initial mechanisms of fibrogenesis.

X-ray diffraction topography. Stages and tendencies of development

International Nuclear Information System (INIS)

Shul'pina, I.L.

2000-01-01

The physical foundation of X-ray diffraction topography, its methods, the achievements in image theory, the stages of evolution were described in this review. It was found that modern topography is well along in development associated with the use of third-generation synchrotron radiation and with its adaptation to advance materials and problems of materials science. Some proposals about prospects for X-ray topography progress in the future have been made [ru

SPIRIT advance care planning intervention in early stage dementias: An NIH stage I behavioral intervention development trial.

Science.gov (United States)

Song, Mi-Kyung; Ward, Sandra E; Hepburn, Kenneth; Paul, Sudeshna; Shah, Raj C; Morhardt, Darby J

2018-06-02

People in the early stages of Alzheimer's disease and related dementias (ADRD) are encouraged to engage in advance care planning (ACP) while they are still competent to appoint a surrogate decision maker and meaningfully participate in ACP discussions with the surrogate. In this NIH Stage I behavioral intervention development trial, we will adapt and test an efficacious ACP intervention, SPIRIT (Sharing Patient's Illness Representation to Increase Trust), with people with mild dementia and their surrogates to promote open, honest discussions while such discussions about end-of-life care are possible. We will first adapt SPIRIT (in person) to target people with mild dementia and their surrogates through a process of modification-pretesting-refinement using stakeholders (persons with mild dementia, family caregivers, and clinicians) and experts, including adapting the delivery mode to interactive web-based videoconference format (SPIRIT-remote). Then in a 3-group RCT with 120 patient-surrogate dyads, we will evaluate the feasibility and acceptability of SPIRIT in-person and SPIRIT remote, and preliminary efficacy of SPIRIT compared to usual care on preparedness outcomes for end-of-life decision making (dyad congruence on goals of care, patient decisional conflict, and surrogate decision-making confidence) shortly after the intervention. This Stage I research of SPIRIT will generate valuable insights regarding how to improve ACP for people with mild dementia who will progress to an advanced stage of the disease in the foreseeable future. ClinicalTrials.gov NCT03311711, Registered 10/12/2017. Copyright © 2018. Published by Elsevier Inc.

Collaboration with Pharma Will Introduce Nanotechnologies in Early Stage Drug Development | Poster

Science.gov (United States)

The Frederick National Lab has begun to assist several major pharmaceutical companies in adopting nanotechnologies in early stage drug development, when the approach is most efficient and cost-effective.

Developing a Logistics Data Process for Support Equipment for NASA Ground Operations

Science.gov (United States)

Chakrabarti, Suman

2010-01-01

The United States NASA Space Shuttle has long been considered an extremely capable yet relatively expensive rocket. A great part of the roughly US $500 million per launch expense was the support footprint: refurbishment and maintenance of the space shuttle system, together with the long list of resources required to support it, including personnel, tools, facilities, transport and support equipment. NASA determined to make its next rocket system with a smaller logistics footprint, and thereby more cost-effective and quicker turnaround. The logical solution was to adopt a standard Logistics Support Analysis (LSA) process based on GEIA-STD-0007 http://www.logisticsengineers.org/may09pres/GEIASTD0007DEXShortIntro.pdf which is the successor of MIL-STD-1388-2B widely used by U.S., NATO, and other world military services and industries. This approach is unprecedented at NASA: it is the first time a major program of programs, Project Constellation, is factoring logistics and supportability into design at many levels. This paper will focus on one of those levels NASA ground support equipment for the next generation of NASA rockets and on building a Logistics Support Analysis Record (LSAR) for developing and documenting a support solution and inventory of resources for. This LSAR is actually a standards-based database, containing analyses of the time and tools, personnel, facilities and support equipment required to assemble and integrate the stages and umbilicals of a rocket. This paper will cover building this database from scratch: including creating and importing a hierarchical bill of materials (BOM) from legacy data; identifying line-replaceable units (LRUs) of a given piece of equipment; analyzing reliability and maintainability of said LRUs; and therefore making an assessment back to design whether the support solution for a piece of equipment is too much work, i.e., too resource-intensive. If one must replace or inspect an LRU too much, perhaps a modification of

Information support of decision-making in the early stages of new product development when approaching marketing management

Directory of Open Access Journals (Sweden)

A. A. Tishhenko

2017-01-01

Full Text Available Goal. To create theoretical and practical approaches to information support of the decision making procedure at the initial stages of developing a new product with a marketing management approach that allows to improve the quality of management decisions on the product. Material and methods. The projected software package on the basis of expert assessments and fuzzy sets, allows to automate the decision to implement innovation at an early stage. The work used such scientific methods as generalization of scientific literature in the field of shaping and taking into account the features of innovation, Solutions in the initial stages of development, methods of expert evaluation and elements of fuzzy sets. Results and its discussion. The article presents the rationale and possibilities for informational support of the decision-making procedure for innovative products. The authors also proposed a methodology for making a decision when developing a new product based on expert and predictive assessments of innovation at the initial stages of its creation. A software package has been developed that automates the decision to manufacture a new product at the initial stages of production. Conclusion. Despite a large number of theoretical developments in innovative management, the risk associated with the release of new products remains quite high. The developed methodology of information support for decision-making at the initial stages of the development of a new product will reduce the risk of the lack of demand for innovation.

Investigation of Intellectual Risk-Taking Abilities of Students According to Piaget's Stages of Cognitive Development and Education Grade

Directory of Open Access Journals (Sweden)

Arzu Derya DAŞCI

2014-07-01

Full Text Available The purpose of this study is to determine the cognitive development stages of students of 4-8th class and is to research the effect to ability of intellectual risk-taking of this periods and education grade. Survey method and clinical method are used in the study which practices for this purpose. In the study which 20 students from every grade, in total 100 students, 6 different activities which are improved and used by different researchers are applied to determine the cognitive development stages whose classification is made by Piaget with Intellectual Risk-Taking and Predictor Scale which was improved by Beghetto (2009. Activities that students made individualistically are marked with observation form and their cognitive development stages are determined according to responses of each. Cognitive development stages and intellectual risk-taking level of students are analyzed with descriptive statistics. In the research result it is seen that majority of students is in the transitional stage and as long as class level increases it is passed to formal operational stage from concrete operational stage. While it is seen that as long as education grade rise intellectual risk-taking abilities of students decreases, it is determined that cognitive development stages has not any effect on this ability. The research is completed with suggestions based on results.

[Histological structure of tripartite mushroom bodies in ground beetles (Insecta, Coleoptera: Carabidae)].

Science.gov (United States)

Panov, A A

2013-01-01

Contrary to members of the suborder Polyphaga; ground beetles have been found to possess tripartite mushroom bodies, which are poorly developed in members of basal taxa and maximally elaborated in evolutionarily advanced groups. Nevertheless, they do not reach the developmental stage, which has been previously found in particular families of beetles. It has been pointed out that anew formation of the Kenyon cells occurs during at least the first months of adult life, and inactive neuroblasts are found even in one-year-old beetles. It has been suggested that there is a relation between the Kenyon cell number and development of the centers of Kenyon cell new-formation.

Development sites, feeding modes and early stages of seven European Palloptera species (Diptera, Pallopteridae).

Science.gov (United States)

Rotheray, Graham E

2014-12-19

Two hundred and ninety-eight rearing records and 87 larvae and puparia were obtained of seven species of Palloptera Fallén (Diptera, Pallopteridae), mainly in Scotland during 2012-2013. The third stage larva and puparium of each species were assessed morphologically and development sites and feeding modes investigated by rearing, observation and feeding tests. Early stages appear to be distinguished by the swollen, apico-lateral margins of the prothorax which are coated in vestiture and a poorly developed anal lobe with few spicules. Individual pallopteran species are separated by features of the head skeleton, locomotory spicules and the posterior respiratory organs. Five species can be distinguished by unique character states. Observations and feeding tests suggest that the frequently cited attribute of zoophagy is accidental and that saprophagy is the primary larval feeding mode with autumn/winter as the main period of development. Food plants were confirmed for flowerhead and stem developing species and rain is important for maintaining biofilms on which larvae feed. Due to difficulties in capturing adults, especially males, the distribution and abundance of many pallopteran species is probably underestimated. Better informed estimates are possible if early stages are included in biodiversity assessments. To facilitate this for the species investigated, a key to the third stage larva and puparium along with details on finding them, is provided. 

Every Picture Tells A Story: Stages of Art Development in Children

African Journals Online (AJOL)

user

2013-07-07

Jul 7, 2013 ... The crux in this work is an analysis of the stages of art development among children .... emotional and cognitive competences in the child. In the same ... a basic property of the nervous system) as well as a psychological need.

The cost of unresectable stage III or stage IV melanoma in Italy

Directory of Open Access Journals (Sweden)

Maio Michele

2012-11-01

Full Text Available Abstract Background In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation in the incidence of melanoma, with the highest rates reported in Scandinavia (15 cases per 100,000 inhabitants per year and the lowest in the Mediterranean countries (5 to 7 cases per 100,000 inhabitants per year. Methods The present article is based on the information collected in the MELODY study (MELanoma treatment patterns and Outcomes among patients with unresectable stage III or stage IV Disease: a retrospective longitudinal survey. In that study, the medical charts of patients were reviewed to document current treatment patterns and to analyse information on patients, disease characteristics and healthcare resource utilization related to the treatment of advanced melanoma regarding patients who presented with a diagnosis of malignant melanoma (stage I to IV at participating sites between 01 July, 2005 and 30 June, 2006. Results Summarizing, though the length of the follow-up period varies among sample patients, an amount of the yearly cost per patient can be estimated, dividing the average per patient total cost (€ 5.040 by the average follow-up duration (17.5 months and reporting to one year; on these grounds, unresectable stage III or stage IV melanoma in Italy would cost € 3,456 per patient per year.

Influence of sports on human mental and physical development in various stages of life

OpenAIRE

SLÁDKOVÁ, Jitka

2011-01-01

The thesis deals with the impact of sports and physical activity on human physical and mental development in various developmental stages of life. It contains a brief description of the stages of life and presents the possibilities, nature and influence of sports and physical activity on human physical and mental state.

Transcriptome Analysis of Calcium- and Hormone-Related Gene Expressions during Different Stages of Peanut Pod Development

Science.gov (United States)

Li, Yan; Meng, Jingjing; Yang, Sha; Guo, Feng; Zhang, Jialei; Geng, Yun; Cui, Li; Wan, Shubo; Li, Xinguo

2017-01-01

Peanut is one of the calciphilous plants. Calcium serves as a ubiquitous central hub in a large number of signaling pathways. In the field, free calcium ion (Ca2+)-deficient soil can result in unfilled pods. Four pod stages were analyzed to determine the relationship between Ca2+ excretion and pod development. Peanut shells showed Ca2+ excretion at all four stages; however, both the embryo of Stage 4 (S4) and the red skin of Stage 3 (S3) showed Ca2+ absorbance. These results showed that embryo and red skin of peanut need Ca2+ during development. In order to survey the relationship among calcium, hormone and seed development from gene perspective, we further analyzed the seed transcriptome at Stage 2 (S2), S3, and S4. About 70 million high quality clean reads were generated, which were assembled into 58,147 unigenes. By comparing these three stages, total 4,457 differentially expressed genes were identified. In these genes, 53 Ca2+ related genes, 40 auxin related genes, 15 gibberellin genes, 20 ethylene related genes, 2 abscisic acid related genes, and 7 cytokinin related genes were identified. Additionally, a part of them were validated by qRT-PCR. Most of their expressions changed during the pod development. Since some reports showed that Ca2+ signal transduction pathway is involved in hormone regulation pathway, these results implied that peanut seed development might be regulated by the collaboration of Ca2+ signal transduction pathway and hormone regulation pathway. PMID:28769950

Transcriptome Analysis of Calcium- and Hormone-Related Gene Expressions during Different Stages of Peanut Pod Development

Directory of Open Access Journals (Sweden)

Yan Li

2017-07-01

Full Text Available Peanut is one of the calciphilous plants. Calcium serves as a ubiquitous central hub in a large number of signaling pathways. In the field, free calcium ion (Ca2+-deficient soil can result in unfilled pods. Four pod stages were analyzed to determine the relationship between Ca2+ excretion and pod development. Peanut shells showed Ca2+ excretion at all four stages; however, both the embryo of Stage 4 (S4 and the red skin of Stage 3 (S3 showed Ca2+ absorbance. These results showed that embryo and red skin of peanut need Ca2+ during development. In order to survey the relationship among calcium, hormone and seed development from gene perspective, we further analyzed the seed transcriptome at Stage 2 (S2, S3, and S4. About 70 million high quality clean reads were generated, which were assembled into 58,147 unigenes. By comparing these three stages, total 4,457 differentially expressed genes were identified. In these genes, 53 Ca2+ related genes, 40 auxin related genes, 15 gibberellin genes, 20 ethylene related genes, 2 abscisic acid related genes, and 7 cytokinin related genes were identified. Additionally, a part of them were validated by qRT-PCR. Most of their expressions changed during the pod development. Since some reports showed that Ca2+ signal transduction pathway is involved in hormone regulation pathway, these results implied that peanut seed development might be regulated by the collaboration of Ca2+ signal transduction pathway and hormone regulation pathway.

Procedures for ground-water investigations

International Nuclear Information System (INIS)

1992-12-01

This manual was developed by the Pacific Northwest Laboratory (PNL) to document the procedures used to carry out and control the technical aspects of ground-water investigations at the PNL. Ground-water monitoring procedures are developed and used in accordance with the PNL Quality Assurance Program

Ground Water in the Anchorage Area, Alaska--Meeting the Challenges of Ground-Water Sustainability

Science.gov (United States)

Moran, Edward H.; Galloway, Devin L.

2006-01-01

Ground water is an important component of Anchorage's water supply. During the 1970s and early 80s when ground water extracted from aquifers near Ship Creek was the principal source of supply, area-wide declines in ground-water levels resulted in near record low streamflows in Ship Creek. Since the importation of Eklutna Lake water in the late 1980s, ground-water use has been reduced and ground water has contributed 14-30 percent of the annual supply. As Anchorage grows, given the current constraints on the Eklutna Lake water availability, the increasing demand for water could place an increasing reliance on local ground-water resources. The sustainability of Anchorage's ground-water resources challenges stakeholders to develop a comprehensive water-resources management strategy.

The automated ground network system

Science.gov (United States)

Smith, Miles T.; Militch, Peter N.

1993-01-01

The primary goal of the Automated Ground Network System (AGNS) project is to reduce Ground Network (GN) station life-cycle costs. To accomplish this goal, the AGNS project will employ an object-oriented approach to develop a new infrastructure that will permit continuous application of new technologies and methodologies to the Ground Network's class of problems. The AGNS project is a Total Quality (TQ) project. Through use of an open collaborative development environment, developers and users will have equal input into the end-to-end design and development process. This will permit direct user input and feedback and will enable rapid prototyping for requirements clarification. This paper describes the AGNS objectives, operations concept, and proposed design.

From Trust to Intimacy: A New Inventory for Examining Erikson's Stages of Psychosocial Development.

Science.gov (United States)

Rosenthal, Doreen A.; And Others

1981-01-01

A new inventory for examining the first six of Erikson's psychosocial stages is described. It is concluded that the Erikson Psychosocial Stage Inventory (EPSI), a self-report questionnaire, is a useful measure for researchers interested in development from early adolescence and in mapping changes as a function of life events. (Author/GK)

The Grounded Theory Bookshelf

Directory of Open Access Journals (Sweden)

Dr. Alvita Nathaniel, DSN, APRN, BC

2005-06-01

Full Text Available The Grounded Theory Perspective III: Theoretical Coding, Barney G. Glaser (Sociology Press, 2005. Not intended for a beginner, this book further defi nes, describes, and explicates the classic grounded theory (GT method. Perspective III lays out various facets of theoretical coding as Glaser meticulously distinguishes classic GT from other subsequent methods. Developed many years after Glaser’s classic GT, these methods, particularly as described by Strauss and Corbin, adopt the grounded theory name and engender ongoing confusion about the very premises of grounded theory. Glaser distinguishes between classic GT and the adscititious methods in his writings, referring to remodeled grounded theory and its offshoots as Qualitative Data Analysis (QDA models.

Stochastic ground motion simulation

Science.gov (United States)

Rezaeian, Sanaz; Xiaodan, Sun; Beer, Michael; Kougioumtzoglou, Ioannis A.; Patelli, Edoardo; Siu-Kui Au, Ivan

2014-01-01

Strong earthquake ground motion records are fundamental in engineering applications. Ground motion time series are used in response-history dynamic analysis of structural or geotechnical systems. In such analysis, the validity of predicted responses depends on the validity of the input excitations. Ground motion records are also used to develop ground motion prediction equations(GMPEs) for intensity measures such as spectral accelerations that are used in response-spectrum dynamic analysis. Despite the thousands of available strong ground motion records, there remains a shortage of records for large-magnitude earthquakes at short distances or in specific regions, as well as records that sample specific combinations of source, path, and site characteristics.

A Grounded Theory Analysis of Introductory Computer Science Pedagogy

Directory of Open Access Journals (Sweden)

Jonathan Wellons

2011-12-01

Full Text Available Planning is a critical, early step on the path to successful program writing and a skill that is often lacking in novice programmers. As practitioners we are continually searching for or creating interventions to help our students, particularly those who struggle in the early stages of their computer science education. In this paper we report on our ongoing research of novice programming skills that utilizes the qualitative research method of grounded theory to develop theories and inform the construction of these interventions. We describe how grounded theory, a popular research method in the social sciences since the 1960’s, can lend formality and structure to the common practice of simply asking students what they did and why they did it. Further, we aim to inform the reader not only about our emerging theories on interventions for planning but also how they might collect and analyze their own data in this and other areas that trouble novice programmers. In this way those who lecture and design CS1 interventions can do so from a more informed perspective.

Volatile Organic Compounds Emissions from Luculia pinceana Flower and Its Changes at Different Stages of Flower Development

Directory of Open Access Journals (Sweden)

Yuying Li

2016-04-01

Full Text Available Luculia plants are famed ornamental plants with sweetly fragrant flowers, of which L. pinceana Hooker, found primarily in Yunnan Province, China, has the widest distribution. Solid phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS was employed to identify the volatile organic compounds (VOCs emitted from different flower development stages of L. pinceana for the evaluation of floral volatile polymorphism. Peak areas were normalized as percentages and used to determine the relative amounts of the volatiles. The results showed that a total of 39 compounds were identified at four different stages of L. pinceana flower development, including 26 at the bud stage, 26 at the initial-flowering stage, 32 at the full-flowering stage, and 32 at the end-flowering stage. The most abundant compound was paeonol (51%–83% followed by (E,E-α-farnesene, cyclosativene, and δ-cadinene. All these volatile compounds create the unique fragrance of L. pinceana flower. Floral scent emission offered tendency of ascending first and descending in succession, meeting its peak level at the initial-flowering stage. The richest diversity of floral volatile was detected at the third and later periods of flower development. Principal component analysis (PCA indicated that the composition and its relative content of floral scent differed throughout the whole flower development. The result has important implications for future floral fragrance breeding of Luculia. L. pinceana would be adequate for a beneficial houseplant and has a promising prospect for development as essential oil besides for a fragrant ornamental owing to the main compounds of floral scent with many medicinal properties.

Early Stages of Figure–Ground Segregation during Perception of the Face–Vase

OpenAIRE

Pitts, Michael A.; Martínez, Antígona; Brewer, James B.; Hillyard, Steven A.

2010-01-01

The temporal sequence of neural processes supporting figure–ground perception was investigated by recording ERPs associated with subjects’ perceptions of the face–vase figure. In Experiment 1, subjects continuously reported whether they perceived the face or the vase as the foreground figure by pressing one of two buttons. Each button press triggered a probe flash to the face region, the vase region, or the borders between the two. The N170/vertex positive potential (VPP) component of the ERP...

INVESTIGATIONS ON BIOCHEMICAL PURIFICATION OF GROUND WATER FROM HYDROGEN SULFIDE

Directory of Open Access Journals (Sweden)

Yu. P. Sedlukho

2015-01-01

Full Text Available The paper considers problems and features of biochemical removal of hydrogen sulfide from ground water. The analysis of existing methods for purification of ground water from hydrogen sulfide has been given in the paper. The paper has established shortcomings of physical and chemical purification of ground water. While using aeration methods for removal of hydrogen sulfide formation of colloidal sulfur that gives muddiness and opalescence to water occurs due to partial chemical air oxidation. In addition to this violation of sulfide-carbonate equilibrium taking place in the process of aeration due to desorption of H2S and CO2, often leads to clogging of degasifier nozzles with formed CaCO3 that causes serious operational problems. Chemical methods require relatively large flow of complex reagent facilities, storage facilities and transportation costs.In terms of hydrogen sulfide ground water purification the greatest interest is given to the biochemical method. Factors deterring widespread application of the biochemical method is its insufficient previous investigation and necessity to execute special research in order to determine optimal process parameters while purifying groundwater of a particular water supply source. Biochemical methods for oxidation of sulfur compounds are based on natural biological processes that ensure natural sulfur cycle. S. Vinogradsky has established a two-stage mechanism for oxidation of hydrogen sulfide with sulfur bacteria (Beggiatoa. The first stage presupposes oxidation of hydrogen sulphide to elemental sulfur which is accumulating in the cytoplasm in the form of globules. During the second stage sulfur bacteria begin to oxidize intracellular sulfur to sulfuric acid due to shortage of hydrogen sulfide.The paper provides the results of technological tests of large-scale pilot plants for biochemical purification of groundwater from hydrogen sulfide in semi-industrial conditions. Dependences of water quality

A three-stage heuristic for harvest scheduling with access road network development

Science.gov (United States)

Mark M. Clark; Russell D. Meller; Timothy P. McDonald

2000-01-01

In this article we present a new model for the scheduling of forest harvesting with spatial and temporal constraints. Our approach is unique in that we incorporate access road network development into the harvest scheduling selection process. Due to the difficulty of solving the problem optimally, we develop a heuristic that consists of a solution construction stage...

GROUND TRANSPORTATION OF NUCLEAR PROPULSION STAGES

Energy Technology Data Exchange (ETDEWEB)

Marjon, P. L.

1963-08-15

The results of studies on transportation problems associated with the development and testing of nuclear rocket powered space vehicles at the static test size are presented. Factors involved in selecting a transport mode are discussed. Radiation shutdown considerations and a conceptual transporter capable of handling test articles of foreseeable size are examined. (D.C.W.)

[Introduction to grounded theory].

Science.gov (United States)

Wang, Shou-Yu; Windsor, Carol; Yates, Patsy

2012-02-01

Grounded theory, first developed by Glaser and Strauss in the 1960s, was introduced into nursing education as a distinct research methodology in the 1970s. The theory is grounded in a critique of the dominant contemporary approach to social inquiry, which imposed "enduring" theoretical propositions onto study data. Rather than starting from a set theoretical framework, grounded theory relies on researchers distinguishing meaningful constructs from generated data and then identifying an appropriate theory. Grounded theory is thus particularly useful in investigating complex issues and behaviours not previously addressed and concepts and relationships in particular populations or places that are still undeveloped or weakly connected. Grounded theory data analysis processes include open, axial and selective coding levels. The purpose of this article was to explore the grounded theory research process and provide an initial understanding of this methodology.

Early two-stage double opposing Z-plasty or one-stage push-back palatoplasty?: comparisons in maxillary development and speech outcome at 4 years of age.

Science.gov (United States)

Yamanishi, Tadashi; Nishio, Juntaro; Sako, Michiyo; Kohara, Hiroshi; Hirano, Yoshiko; Yamanishi, Yukiko; Adachi, Tadafumi; Miya, Shigenori; Mukai, Takao

2011-02-01

Determining the optimal timing and procedure of palatal surgery for children with cleft lip and palate has long raised a major controversy. An early two-stage palatoplasty protocol has been a recent trend in an attempt to obtain preferable maxillary growth without compromising adequate speech development. In this study, we aim to address whether the resulting maxillofacial growth and speech development obtained by an early 2-stage palatoplasty protocol are better than those obtained by conventional 1-stage push-back palatoplasty. Seventy-two nonsyndromic children with complete unilateral cleft lip and palate were enrolled in this study. They were divided into 2 groups: 30 children, who were treated with early 2-stage palatoplasty, in which soft palate closure was performed using a modified Furlow's procedure at 12 months of age and hard palate closure was performed at 18 months of age (Early Tow Stage [ETS] group: 22 boys, 8 girls), and 42 children, who underwent 1-stage Wardill-Kilner push-back palatoplasty at 12 months of age (Push Back [PB] group: 31 boys, 11 girls). Cephalometric analysis for maxillofacial growth and assessments of speech development were performed for each child at 4 years of age. The ETS group showed a lager maxillary length than the PB group [anterior nasal spine (ANS)-ptm': ETS, 46.7 ± 2.0 mm; PB, 43.6 ± 2.3 mm]. The ANS in the ETS group was positioned more anteriorly than that in the PB group (N'-ANS: ETS, 2.5 ± 1.8 mm; PB, 0.26 ± 2.5 mm), whereas the posterior edge of the maxilla positioned anteroposteiorly was comparable between the 2 groups. The anterior facial height was significantly greater in the ETS group than in the PB group (N-N': ETS, 43.3 ± 2.9 mm; PB, 40.1 ± 2.3 mm, S-S': ETS, 29.7 ± 3.2 mm; PB, 31.0 ± 3.2 mm). No statistically significant differences were observed in the incidence of either velopharyngeal incompetence or articulation errors between the 2 groups at 4 years of age. Our results show that the early 2

Development and verification of ground-based tele-robotics operations concept for Dextre

Science.gov (United States)

Aziz, Sarmad

2013-05-01

The Special Purpose Dextreous Manipulator (Dextre) is the latest addition to the on-orbit segment of the Mobile Servicing System (MSS); Canada's contribution to the International Space Station (ISS). Launched in March 2008, the advanced two-armed robot is designed to perform various ISS maintenance tasks on robotically compatible elements and on-orbit replaceable units using a wide variety of tools and interfaces. The addition of Dextre has increased the capabilities of the MSS, and has introduced significant complexity to ISS robotics operations. While the initial operations concept for Dextre was based on human-in-the-loop control by the on-orbit astronauts, the complexities of robotic maintenance and the associated costs of training and maintaining the operator skills required for Dextre operations demanded a reexamination of the old concepts. A new approach to ISS robotic maintenance was developed in order to utilize the capabilities of Dextre safely and efficiently, while at the same time reducing the costs of on-orbit operations. This paper will describe the development, validation, and on-orbit demonstration of the operations concept for ground-based tele-robotics control of Dextre. It will describe the evolution of the new concepts from the experience gained from the development and implementation of the ground control capability for the Space Station Remote Manipulator System; Canadarm 2. It will discuss the various technical challenges faced during the development effort, such as requirements for high positioning accuracy, force/moment sensing and accommodation, failure tolerance, complex tool operations, and the novel operational tools and techniques developed to overcome them. The paper will also describe the work performed to validate the new concepts on orbit and will discuss the results and lessons learned from the on-orbit checkout and commissioning of Dextre using the newly developed tele-robotics techniques and capabilities.

Turbine stage model

International Nuclear Information System (INIS)

Kazantsev, A.A.

2009-01-01

A model of turbine stage for calculations of NPP turbine department dynamics in real time was developed. The simulation results were compared with manufacturer calculations for NPP low-speed and fast turbines. The comparison results have shown that the model is valid for real time simulation of all modes of turbines operation. The model allows calculating turbine stage parameters with 1% accuracy. It was shown that the developed turbine stage model meets the accuracy requirements if the data of turbine blades setting angles for all turbine stages are available [ru

A Project to Help Child Development Students Recognize Piagetian Developmental Stages.

Science.gov (United States)

Husmann, Ann

This practicum report was designed to help child development students differentiate between the preoperational and concrete operational stages of the Piagetian cognitive hierarchy. The 36 on-campus and 63 instructional television students used a Piagetian Game booklet, which is included in the appendix. Using this booklet, students were able to…

Applying a particle filtering technique for canola crop growth stage estimation in Canada

Science.gov (United States)

Sinha, Abhijit; Tan, Weikai; Li, Yifeng; McNairn, Heather; Jiao, Xianfeng; Hosseini, Mehdi

2017-10-01

Accurate crop growth stage estimation is important in precision agriculture as it facilitates improved crop management, pest and disease mitigation and resource planning. Earth observation imagery, specifically Synthetic Aperture Radar (SAR) data, can provide field level growth estimates while covering regional scales. In this paper, RADARSAT-2 quad polarization and TerraSAR-X dual polarization SAR data and ground truth growth stage data are used to model the influence of canola growth stages on SAR imagery extracted parameters. The details of the growth stage modeling work are provided, including a) the development of a new crop growth stage indicator that is continuous and suitable as the state variable in the dynamic estimation procedure; b) a selection procedure for SAR polarimetric parameters that is sensitive to both linear and nonlinear dependency between variables; and c) procedures for compensation of SAR polarimetric parameters for different beam modes. The data was collected over three crop growth seasons in Manitoba, Canada, and the growth model provides the foundation of a novel dynamic filtering framework for real-time estimation of canola growth stages using the multi-sensor and multi-mode SAR data. A description of the dynamic filtering framework that uses particle filter as the estimator is also provided in this paper.

The Development of Proportional Reasoning and the Ratio Concept: Part I - Differentiation of Stages.

Science.gov (United States)

Noelting, Gerald

1980-01-01

This study considers two problems related to cognitive development: "Is development hierarchical?" and "If so, what are the mechanisms involved in the process of development?" Analysis of the results of an experiment lead to differentiation of stages of development, and problem-solving strategies at each level are discussed.…

Engineering-geophysical criteria for evaluating the development stages of landslides in loess rocks

Energy Technology Data Exchange (ETDEWEB)

Abdullayev, S K

1981-01-01

As a result of conducting geophysical observations on landslide slopes formed by loess rocks, with their artifical moistening, quantitiative engineering-geophysical criteria were obtained which characterize the basic stages of landslide development. The studies were conducted by surface methods of electrical resistance and seismometry conducted directly in the massif. According to the indicators of moisture content, state of comminution, compactness calculated with the help of geophysical parameters, the stage of preparation and movement of landslides are characterized.

Consideration of the restoring plan in subsidence prone areas through the development of ground stability assessment techniques

Energy Technology Data Exchange (ETDEWEB)

Kwon, Kwang-Soo; Kim, Im-Ho; Baek, Sang-Ho [Korea Institute of Geology Mining and Materials, Taejon (KR)] (and others)

1999-12-01

This report consists of 2 subjects. (1) Consideration of the restoring plan in subsidence prone areas through the development of ground stability assessment techniques : The number of mines at rest as well as closed have abruptly increased since the 1980's, which has caused subsidence problems around the mined areas. To protect such places from damage due to subsidence, it is necessary to develop the assessment techniques of ground stability and make restoration plan. To achieve this goal, the site investigation should have been conducted before the subsidence events occurred, but ground behaviors around the places where a vertical movement is expected and recognised in advance before the occurrence of the subsidence events. In this study ground stability analysis for the area surrounding the Moo-Geuk Mine, located close to a city, was conducted and the measurements were recorded. The objectives of the present study include, the development of a risk assessment technique for the subsidence using GIS tool, an evaluation of the numerical methods related to the site investigation and the ground stability analysis, the application of the numerical tools to the present problems. (2) Integration of coal mine data and use of remote sensing in investigation of coal mine area : This study attempt to integrate the previous geological and mining data to avoid confusions often occurred when accessing source data. And the investigation of underground mining place using remote sensing method is the other effort to assure the geographic locations of mining places as well as to find out unknown mining place. The sample region for examining the remote sensing method is the Chungnam coal field, which locates in the middle western part of South Korea. Detailed investigation was held on the Seongju area, locating north eastern part of the coal field. (author). 54 refs., tabs., figs.

Solar thermal upper stage: Economic advantage and development status

Science.gov (United States)

Adams, Alan M.

1995-01-01

A solar thermal upper stage (STUS) is envisioned as a propulsive concept for the future. The STUS will be used for low Earth orbit (LEO) to geostationary-Earth orbit (GEO) transfer and for planetary exploration missions. The STUS offers significant performance gains over conventional chemical propulsion systems. These performance gains translate into a more economical, more efficient method of placing useful payloads in space and maximizing the benefits derived from space activity. This paper will discuss the economical advantages of an STUS compared to conventional chemical propulsion systems, the potential market for an STUS, and the recent activity in the development of an STUS. The results of this assessment combined with the performance gains, will provide a strong justification for the development of an STUS.

Ground squirrel shooting and potential lead exposure in breeding avian scavengers

Science.gov (United States)

Herring, Garth; Eagles-Smith, Collin A.; Wagner, Mason T.

2016-01-01

Recreational ground squirrel shooting is a popular activity throughout the western United States and serves as a tool for managing ground squirrel populations in agricultural regions. Belding’s ground squirrels (Spermophilus beldingi) are routinely shot in California, Nevada, and Oregon across habitats that overlap with breeding avian scavengers. Ground squirrels shot with lead (Pb)-based bullets may pose a risk to avian scavengers if they consume carcasses containing Pb fragments. To assess the potential risk to breeding avian scavengers we developed a model to estimate the number, mass, and distribution of Pb fragments in shot ground squirrels using radiographic images. Eighty percent of shot carcasses contained detectible Pb fragments with an average of 38.6 mg of Pb fragments. Seven percent of all carcasses contained Pb fragment masses exceeding a lethal dose for a model raptor nestling (e.g. American kestrel Falco sparverius). Bullet type did not influence the number of fragments in shot ground squirrels, but did influence the mass of fragments retained. Belding’s ground squirrels shot with .17 Super Mag and unknown ammunition types contained over 28 and 17 times more mass of Pb fragments than those shot with .22 solid and .22 hollow point bullets, respectively. Ground squirrel body mass was positively correlated with both the number and mass of Pb fragments in carcasses, increasing on average by 76% and 56% respectively across the range of carcass masses. Although the mass of Pb retained in ground squirrel carcasses was small relative to the original bullet mass, avian scavenger nestlings that frequently consume shot ground squirrels may be at risk for Pb-induced effects (e.g., physiology, growth, or survival). Using modeling efforts we found that if nestling golden eagles (Aquila chrysaetos), red-tailed hawks (Buteo jamaicensis), and Swainson’s hawks (B. swainsoni) consumed shot ground squirrels proportionately to the nestling’s mass, energy needs

Ground Squirrel Shooting and Potential Lead Exposure in Breeding Avian Scavengers.

Directory of Open Access Journals (Sweden)

Garth Herring

Full Text Available Recreational ground squirrel shooting is a popular activity throughout the western United States and serves as a tool for managing ground squirrel populations in agricultural regions. Belding's ground squirrels (Spermophilus beldingi are routinely shot in California, Nevada, and Oregon across habitats that overlap with breeding avian scavengers. Ground squirrels shot with lead (Pb-based bullets may pose a risk to avian scavengers if they consume carcasses containing Pb fragments. To assess the potential risk to breeding avian scavengers we developed a model to estimate the number, mass, and distribution of Pb fragments in shot ground squirrels using radiographic images. Eighty percent of shot carcasses contained detectible Pb fragments with an average of 38.6 mg of Pb fragments. Seven percent of all carcasses contained Pb fragment masses exceeding a lethal dose for a model raptor nestling (e.g. American kestrel Falco sparverius. Bullet type did not influence the number of fragments in shot ground squirrels, but did influence the mass of fragments retained. Belding's ground squirrels shot with .17 Super Mag and unknown ammunition types contained over 28 and 17 times more mass of Pb fragments than those shot with .22 solid and .22 hollow point bullets, respectively. Ground squirrel body mass was positively correlated with both the number and mass of Pb fragments in carcasses, increasing on average by 76% and 56% respectively across the range of carcass masses. Although the mass of Pb retained in ground squirrel carcasses was small relative to the original bullet mass, avian scavenger nestlings that frequently consume shot ground squirrels may be at risk for Pb-induced effects (e.g., physiology, growth, or survival. Using modeling efforts we found that if nestling golden eagles (Aquila chrysaetos, red-tailed hawks (Buteo jamaicensis, and Swainson's hawks (B. swainsoni consumed shot ground squirrels proportionately to the nestling's mass, energy

Forensic age estimation based on development of third molars: a staging technique for magnetic resonance imaging.

Science.gov (United States)

De Tobel, J; Phlypo, I; Fieuws, S; Politis, C; Verstraete, K L; Thevissen, P W

2017-12-01

The development of third molars can be evaluated with medical imaging to estimate age in subadults. The appearance of third molars on magnetic resonance imaging (MRI) differs greatly from that on radiographs. Therefore a specific staging technique is necessary to classify third molar development on MRI and to apply it for age estimation. To develop a specific staging technique to register third molar development on MRI and to evaluate its performance for age estimation in subadults. Using 3T MRI in three planes, all third molars were evaluated in 309 healthy Caucasian participants from 14 to 26 years old. According to the appearance of the developing third molars on MRI, descriptive criteria and schematic representations were established to define a specific staging technique. Two observers, with different levels of experience, staged all third molars independently with the developed technique. Intra- and inter-observer agreement were calculated. The data were imported in a Bayesian model for age estimation as described by Fieuws et al. (2016). This approach adequately handles correlation between age indicators and missing age indicators. It was used to calculate a point estimate and a prediction interval of the estimated age. Observed age minus predicted age was calculated, reflecting the error of the estimate. One-hundred and sixty-six third molars were agenetic. Five percent (51/1096) of upper third molars and 7% (70/1044) of lower third molars were not assessable. Kappa for inter-observer agreement ranged from 0.76 to 0.80. For intra-observer agreement kappa ranged from 0.80 to 0.89. However, two stage differences between observers or between staging sessions occurred in up to 2.2% (20/899) of assessments, probably due to a learning effect. Using the Bayesian model for age estimation, a mean absolute error of 2.0 years in females and 1.7 years in males was obtained. Root mean squared error equalled 2.38 years and 2.06 years respectively. The performance to

Buddhism in the Astrakhan territory: stages of the historical development

Directory of Open Access Journals (Sweden)

Андрей Алексеевич Курапов

2010-03-01

Full Text Available In authors article are considered the basic stages of distribution of the Buddhism on the Bottom Volga region, within the limits of the Astrakhan province. Analysed characteristic features of historical development of a Buddhist community (sangha at Kalmyks, participation of Buddhist clergy in political life of region. Determined and considered specificity of interaction of a Buddhist community with secular authorities of region and national elite.

Stages of Psychometric Measure Development: The Example of the Generalized Expertise Measure (GEM)

Science.gov (United States)

Germain, Marie-Line

2006-01-01

This paper chronicles the steps, methods, and presents hypothetical results of quantitative and qualitative studies being conducted to develop a Generalized Expertise Measure (GEM). Per Hinkin (1995), the stages of scale development are domain and item generation, content expert validation, and pilot test. Content/face validity and internal…

Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development.

Science.gov (United States)

Rijpma, Sanna R; van der Velden, Maarten; Annoura, Takeshi; Matz, Joachim M; Kenthirapalan, Sanketha; Kooij, Taco W A; Matuschewski, Kai; van Gemert, Geert-Jan; van de Vegte-Bolmer, Marga; Siebelink-Stoter, Rianne; Graumans, Wouter; Ramesar, Jai; Klop, Onny; Russel, Frans G M; Sauerwein, Robert W; Janse, Chris J; Franke-Fayard, Blandine M; Koenderink, Jan B

2016-07-01

Multidrug resistance (MDR) proteins belong to the B subfamily of the ATP Binding Cassette (ABC) transporters, which export a wide range of compounds including pharmaceuticals. In this study, we used reverse genetics to study the role of all seven Plasmodium MDR proteins during the life cycle of malaria parasites. Four P. berghei genes (encoding MDR1, 4, 6 and 7) were refractory to deletion, indicating a vital role during blood stage multiplication and validating them as potential targets for antimalarial drugs. Mutants lacking expression of MDR2, MDR3 and MDR5 were generated in both P. berghei and P. falciparum, indicating a dispensable role for blood stage development. Whereas P. berghei mutants lacking MDR3 and MDR5 had a reduced blood stage multiplication in vivo, blood stage growth of P. falciparum mutants in vitro was not significantly different. Oocyst maturation and sporozoite formation in Plasmodium mutants lacking MDR2 or MDR5 was reduced. Sporozoites of these P. berghei mutants were capable of infecting mice and life cycle completion, indicating the absence of vital roles during liver stage development. Our results demonstrate vital and dispensable roles of MDR proteins during blood stages and an important function in sporogony for MDR2 and MDR5 in both Plasmodium species. © 2016 John Wiley & Sons Ltd.

Bedrock geology Forsmark. Modelling stage 2.3. Implications for and verification of the deterministic geological models based on complementary data

Energy Technology Data Exchange (ETDEWEB)

Stephens, Michael B. (Geological Survey of Sweden, Uppsala (Sweden)); Simeonov, Assen (Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)); Isaksson, Hans (GeoVista AB, Luleaa (Sweden))

2008-12-15

The Swedish Nuclear Fuel and Waste Management Company is in the process of completing site descriptive modelling at two locations in Sweden, with the objective to site a deep geological repository for spent nuclear fuel. At Forsmark, the results of the stage 2.2 geological modelling formed the input for downstream users. Since complementary ground and borehole geological and geophysical data, acquired after model stage 2.2, were not planned to be included in the deterministic rock domain, fracture domain and deformation zone models supplied to the users, it was deemed necessary to evaluate the implications of these stage 2.3 data for the stage 2.2 deterministic geological models and, if possible, to make use of these data to verify the models. This report presents the results of the analysis of the complementary stage 2.3 geological and geophysical data. Model verification from borehole data has been implemented in the form of a prediction-outcome test. The stage 2.3 geological and geophysical data at Forsmark mostly provide information on the bedrock outside the target volume. Additional high-resolution ground magnetic data and the data from the boreholes KFM02B, KFM11A, KFM12A and HFM33 to HFM37 can be included in this category. Other data complement older information of identical character, both inside and outside this volume. These include the character and kinematics of deformation zones and fracture mineralogy. In general terms, it can be stated that all these new data either confirm the geological modelling work completed during stage 2.2 or are in good agreement with the data that were used in this work. In particular, although the new high-resolution ground magnetic data modify slightly the position and trace length of some stage 2.2 deformation zones at the ground surface, no new or modified deformation zones with a trace length longer than 3,000 m at the ground surface have emerged. It is also apparent that the revision of fracture orientation data

Bedrock geology Forsmark. Modelling stage 2.3. Implications for and verification of the deterministic geological models based on complementary data

International Nuclear Information System (INIS)

Stephens, Michael B.; Simeonov, Assen; Isaksson, Hans

2008-12-01

The Swedish Nuclear Fuel and Waste Management Company is in the process of completing site descriptive modelling at two locations in Sweden, with the objective to site a deep geological repository for spent nuclear fuel. At Forsmark, the results of the stage 2.2 geological modelling formed the input for downstream users. Since complementary ground and borehole geological and geophysical data, acquired after model stage 2.2, were not planned to be included in the deterministic rock domain, fracture domain and deformation zone models supplied to the users, it was deemed necessary to evaluate the implications of these stage 2.3 data for the stage 2.2 deterministic geological models and, if possible, to make use of these data to verify the models. This report presents the results of the analysis of the complementary stage 2.3 geological and geophysical data. Model verification from borehole data has been implemented in the form of a prediction-outcome test. The stage 2.3 geological and geophysical data at Forsmark mostly provide information on the bedrock outside the target volume. Additional high-resolution ground magnetic data and the data from the boreholes KFM02B, KFM11A, KFM12A and HFM33 to HFM37 can be included in this category. Other data complement older information of identical character, both inside and outside this volume. These include the character and kinematics of deformation zones and fracture mineralogy. In general terms, it can be stated that all these new data either confirm the geological modelling work completed during stage 2.2 or are in good agreement with the data that were used in this work. In particular, although the new high-resolution ground magnetic data modify slightly the position and trace length of some stage 2.2 deformation zones at the ground surface, no new or modified deformation zones with a trace length longer than 3,000 m at the ground surface have emerged. It is also apparent that the revision of fracture orientation data

Stages of Biological Development across Age: An Analysis of Canadian Health Measure Survey 2007-2011.

Science.gov (United States)

Chao, Yi-Sheng; Wu, Hsing-Chien; Wu, Chao-Jung; Chen, Wei-Chih

2017-01-01

The stages of biological development are not clearly defined despite the fact that they have been used to refer to concepts such as adolescence and aging. This study aimed to (1) propose and test a framework to search for stages of representative components and determine stages of stability and transition, (2) identify stages of biological development based on health questionnaire and biomarker data, and (3) interpret the major trajectories in a health and biomarker database. This study analyzed the data on the Canadian Health Measures Survey (CHMS) interviewees from cycle 1 to 3 (2007-2013) in Canada. We selected 282 variables containing information from questionnaire and on biomarkers after removing redundant variables based on high correlation. Fifty-nine nominal variables were replaced by 122 binominal variables, leaving 345 variables for analysis. Principal component (PC) analysis was conducted to summarize the data and the loadings were used to interpret the PCs. A stable stage was assumed to be the age groups without significantly different values of PCs. The CHMS interviewed 16,340 Canadians. Of all, 51.25% were female. The age ranged from 6 to 79 years (mean = 34.41 years, 95% CI = 34.74-34.08). The proportions of total variance explained by the first three PCs were 12.14, 4.03, and 3.19%, respectively. The differences of the first PC were not significant, especially between age 22 and 33, 34 and 40, 41 and 45, 46 and 71, and 72 and 79 years (adjusted p  > 0.05 for all). The leading variable, in terms of the variance contributed to PC1, was time spent in physical activities, followed by variables related to alcohol consumption, and smoking. The 13 leading contributors to PC2 variances were all lung function measures. There are stages of stability and transition across all age groups based on the first PCs. The first and second PCs are related to physical development and lung function. The identification of stable stages is the first step

TRL Assessment of Solar Sail Technology Development Following the 20-Meter System Ground Demonstrator Hardware Testing

Science.gov (United States)

Young, Roy M.; Adams, Charles L.

2010-01-01

The NASA In-Space Propulsion Technology (ISPT) Projects Office sponsored two separate, independent solar sail system design and development demonstration activities during 2002-2005. ATK Space Systems of Goleta, CA was the prime contractor for one development team and L' Garde, Inc. of Tustin, CA was the prime contractor for the other development team. The goal of these activities was to advance the technology readiness level (TRL) of solar sail propulsion from 3 towards 6 by the year 2006. Component and subsystem fabrication and testing were completed successfully, including the ground deployment of 10-meter and 20-meter demonstration hardware systems under vacuum conditions. The deployment and structural testing of the 20-meter solar sail systems was conducted in the 30 meter diameter Space Power Facility thermal-vacuum chamber at NASA Glenn Plum Brook in April though August, 2005. This paper will present the results of the TRL assessment following the solar sail technology development activities associated with the design, development, analysis and testing of the 20-meter system ground demonstrators.

The effect of flurbiprofen on the development of anencephaly in early stage chicken embryos.

Science.gov (United States)

Özeren, Ersin; Er, Uygur; Güvenç, Yahya; Demirci, Adnan; Arıkök, Ata Türker; Şenveli, Engin; Ergün, Rüçhan Behzat

2015-04-01

The study investigated the effect of flurbiprofen on the development of anencephaly in early stage chicken embryos. We looked at four groups with a total of 36 embryos. There was a control group, a normal saline group, a normal-dose group and a high-dose group with ten, ten, eight and eight eggs with embryo respectively. Two embryos in the control group, studied with light microscopy at 48 h, were consistent with 28-29 hours' incubation in the Hamburger-Hamilton System. They had open neural tubes. The other embryos in this group were considered normal. One embryo in the normal saline group was on the occlusion stage at 48 h. One embryo showed an open neural tube. They were compatible with 28-29 hours' incubation in the Hamburger-Hamilton system. The remaining eight embryos showed normal development. In the normal dose group, one embryo showed underdevelopment of the embryonic disc and the embryo was dead. In four embryos, the neural tubes were open. One cranial malformation was found that was complicated with anencephaly in one embryo. In two embryos the neural tubes were closed, as they showed normal development, and they reached their expected stages according to the Hamburger-Hamilton classification. There was no malformation or growth retardation. Four experimental embryos were anencephalic in the high dose group, and three embryos had open neural tubes. One embryo exhibited both anencephaly and a neural tube closure defect. None of the embryos in this group showed normal development. Even the usual therapeutic doses of flurbiprofen increased the risk of neural tube defect. Flurbiprofen was found to significantly increase the risk of anencephaly. The provision of improved technical materials and studies with larger sample sizes will reveal the stage of morphological disruption during the development of embryos.

Preparatory research to develop an operational method to calibrate airborne sensor data using a network of ground calibration sites

International Nuclear Information System (INIS)

Milton, E.J.; Smith, G.M.; Lawless, K.P.

1996-01-01

The objective of the research is to develop an operational method to convert airborne spectral radiance data to reflectance using a number of well-characterized ground calibration sites located around the UK. The study is in three phases. First, a pilot study has been conducted at a disused airfield in southern England to test the feasibility of the open-quote empirical line close-quote method of sensor calibration. The second phase is developing methods to predict temporal changes in the bidirectional reflectance of ground calibration sites. The final phase of the project will look at methods to extend such calibrations spatially. This paper presents some results from the first phase of this study. The viability of the empirical line method of correction is shown to depend upon the use of ground targets whose in-band reflectance encompasses that of the targets of interest in the spectral band(s) concerned. The experimental design for the second phase of the study, in which methods to predict temporal trends in the bidirectional reflectance of these sites will be developed, is discussed. Finally, it is planned to develop an automated method of searching through Landsat TM data for the UK to identify a number of candidate ground calibration sites for which the model can be tested. 11 refs., 5 figs., 5 tabs

Review of Ground Systems Development and Operations (GSDO) Tools for Verifying Command and Control Software

Science.gov (United States)

Aguilar, Michael L.; Bonanne, Kevin H.; Favretto, Jeffrey A.; Jackson, Maddalena M.; Jones, Stephanie L.; Mackey, Ryan M.; Sarrel, Marc A.; Simpson, Kimberly A.

2014-01-01

The Exploration Systems Development (ESD) Standing Review Board (SRB) requested the NASA Engineering and Safety Center (NESC) conduct an independent review of the plan developed by Ground Systems Development and Operations (GSDO) for identifying models and emulators to create a tool(s) to verify their command and control software. The NESC was requested to identify any issues or weaknesses in the GSDO plan. This document contains the outcome of the NESC review.

Development of a hybrid mode linear transformer driver stage

Science.gov (United States)

Zhang, Le; Wang, Meng; Zhou, Liangji; Tian, Qing; Guo, Fan; Wang, Lingyun; Qing, Yanling; Zhao, Yue; Dai, Yingmin; Han, Wenhui; Chen, Lin; Xie, Weiping

2018-02-01

At present, the mainstream technologies of primary power sources of large pulse power devices adopt Marx or linear transformer driver (LTD) designs. Based on the analysis of the characteristics of these two types of circuit topologies, the concept of a hybrid mode LTD stage based on Marx branches is proposed. The analysis shows that the hybrid mode LTD stage can realize the following goals: (a) to reduce the energy and power handled by the basic components (switch and capacitor) to lengthen their lifetime; (b) to reduce the requirements of the multipath synchronous trigger system; and (c) to improve the maintainability of the LTD stage by using independent Marx generators instead of "traditional LTD bricks." To verify the technique, a hybrid mode LTD stage consisting of 50 branches (four-stage compact Marx generators) was designed, manufactured and tested. The stage has a radius of about 3.3 m and a height of 0.6 m. The single Marx circuit's load current is about 21 kA, with a rise time of ˜90 ns (10%-90%), under the conditions of capacitors charged to ±40 kV and a 6.9 Ω matched load. The whole stage's load current is ˜1 MA , with a rise time of ˜112 ns (10%-90%), when the capacitors are charged to ±45 kV and the matched load is 0.14 Ω .

Organ-Specific Metabolic Shifts of Flavonoids in Scutellaria baicalensis at Different Growth and Development Stages

Directory of Open Access Journals (Sweden)

Jingyuan Xu

2018-02-01

Full Text Available Scutellaria baicalensis Georgi is a traditional Chinese herbal medicine mainly containing flavonoids that contribute to its bioactivities. In this study, the distributions and dynamic changes of flavonoid levels in various organs of S. baicalensis at different development stages were investigated by UHPLC-QTOF-MS/MS and HPLC-DAD methods. The results indicated that the metabolic profiles of S. baicalensis changed with growth and development. During the initial germination stage, the seeds mainly contained flavonols. With growth, the main kinds of flavonoids in S. baicalensis changed from flavonols to flavanones and flavones. The results also revealed that the accumulation of flavonoids in S. baicalensis is organ-specific. The flavones without 4′-OH groups mainly accumulate in the root and the flavanones mainly accumulate in aerial organs. Dynamic accumulation analysis showed that the main flavonoids in the root of S. baicalensis accumulated rapidly before the full-bloom stage, then changed to a small extent. The results suggested the proper harvest time for the aerial parts was at the initial stage of reproductive growth and the flower buds should be collected before flowering. This study deepening the knowledge of S. baicalensis should provide valuable information for guiding the scientific cultivation of this plant and the development and utilization of S. baicalensis.

Generating or developing grounded theory: methods to understand health and illness.

Science.gov (United States)

Woods, Phillip; Gapp, Rod; King, Michelle A

2016-06-01

Grounded theory is a qualitative research methodology that aims to explain social phenomena, e.g. why particular motivations or patterns of behaviour occur, at a conceptual level. Developed in the 1960s by Glaser and Strauss, the methodology has been reinterpreted by Strauss and Corbin in more recent times, resulting in different schools of thought. Differences arise from different philosophical perspectives concerning knowledge (epistemology) and the nature of reality (ontology), demanding that researchers make clear theoretical choices at the commencement of their research when choosing this methodology. Compared to other qualitative methods it has ability to achieve understanding of, rather than simply describing, a social phenomenon. Achieving understanding however, requires theoretical sampling to choose interviewees that can contribute most to the research and understanding of the phenomenon, and constant comparison of interviews to evaluate the same event or process in different settings or situations. Sampling continues until conceptual saturation is reached, i.e. when no new concepts emerge from the data. Data analysis focusses on categorising data (finding the main elements of what is occurring and why), and describing those categories in terms of properties (conceptual characteristics that define the category and give meaning) and dimensions (the variations within properties which produce specificity and range). Ultimately a core category which theoretically explains how all other categories are linked together is developed from the data. While achieving theoretical abstraction in the core category, it should be logical and capture all of the variation within the data. Theory development requires understanding of the methodology not just working through a set of procedures. This article provides a basic overview, set in the literature surrounding grounded theory, for those wanting to increase their understanding and quality of research output.

"Putting My Man Face on": A Grounded Theory of College Men's Gender Identity Development

Science.gov (United States)

Edwards, Keith E.; Jones, Susan R.

2009-01-01

The theory that emerged from this constructivist grounded theory study of 10 college men's experiences depicts their gender identity as developed through constant interaction with society's expectations of them as men. In order to try to meet these perceived expectations, participants described putting on a performance that was like wearing a mask…

Development and testing of a two stage granular filter to improve collection efficiency

Energy Technology Data Exchange (ETDEWEB)

Rangan, R.S.; Prakash, S.G.; Chakravarti, S.; Rao, S.R.

1999-07-01

A circulating bed granular filter (CBGF) with a single filtration stage was tested with a PFB combustor in the Coal Research Facility of BHEL R and D in Hyderabad during the years 1993--95. Filter outlet dust loading varied between 20--50 mg/Nm{sup 3} for an inlet dust loading of 5--8 gms/Nm{sup 3}. The results were reported in Fluidized Bed Combustion-Volume 2, ASME 1995. Though the outlet consists of predominantly fine particulates below 2 microns, it is still beyond present day gas turbine specifications for particulate concentration. In order to enhance the collection efficiency, a two-stage granular filtration concept was evolved, wherein the filter depth is divided between two stages, accommodated in two separate vertically mounted units. The design also incorporates BHEL's scale-up concept of multiple parallel stages. The two-stage concept minimizes reentrainment of captured dust by providing clean granules in the upper stage, from where gases finally exit the filter. The design ensures that dusty gases come in contact with granules having a higher dust concentration at the bottom of the two-stage unit, where most of the cleaning is completed. A second filtration stage of cleaned granules is provided in the top unit (where the granules are returned to the system after dedusting) minimizing reentrainment. Tests were conducted to determine the optimum granule to dust ratio (G/D ratio) which decides the granule circulation rate required for the desired collection efficiency. The data brings out the importance of pre-separation and the limitation on inlet dust loading for any continuous system of granular filtration. Collection efficiencies obtained were much higher (outlet dust being 3--9 mg/Nm{sub 3}) than in the single stage filter tested earlier for similar dust loading at the inlet. The results indicate that two-stage granular filtration has a high potential for HTHT application with fewer risks as compared to other systems under development.

Development of 52 inch last stage blade for steam turbine

International Nuclear Information System (INIS)

Kadoya, Yoshiki; Harada, Masakatsu; Watanabe, Eiichiro

1985-01-01

Mitsubishi Heavy Industries, Ltd. has developed the last stage blades with 1320 mm length for a 1800 rpm LP turbine, and the verification by rotating vibration test using actual blades was finished, thus the blades were completed. In a nuclear power plant with an A-PWR of 3800 MW thermal output, the 1350 MW steam turbine has one HP turbine and three LP turbines coupled in tandem, and the optimum last stage blades for the LP turbines became the 1320 mm blades. The completion of these blades largely contributes to the improvement of thermal efficiency and the increase of generator output in large nuclear power plants, and has the possibility to decrease three LP turbines to two in 900 MW plants, which reduces the construction cost. The velocity energy of steam coming out of last stage blades is abandoned as exhaust loss in a condenser, which is the largest loss in a turbine. The increase of exhaust area using long blades reduces this loss. The economy of the 1320 mm blades, the features of the 1320 mm blades, the aerodynamic design and its verification, the prevention of the erosion of the 1320 mm blades due to wet steam, the strength design, the anti-vibration design and its verification, and the CAD/CAM system are reported. (Kako, I.)

Guidelines for determining design basis ground motions

International Nuclear Information System (INIS)

1993-11-01

This report develops and applies a method for estimating strong earthquake ground motion. The emphasis of this study is on ground motion estimation in Eastern North America (east of the Rocky Mountains), with particular emphasis on the Eastern United States and southeastern Canada. Specifically considered are ground motions resulting from earthquakes with magnitudes from 5 to 8, fault distances from 0 to 500 km, and frequencies from 1 to 35 Hz. The two main objectives were: (1) to develop generic relations for estimating ground motion appropriate for site screening; and (2) to develop a guideline for conducting a thorough site investigation needed to define the seismic design basis. For the first objective, an engineering model was developed to predict the expected ground motion on rock sites, with an additional set of amplification factors to account for the response of the soil column over rock at soil sites. The results incorporate best estimates of ground motion as well as the randomness and uncertainty associated with those estimates. For the second objective, guidelines were developed for gathering geotechnical information at a site and using this information in calculating site response. As a part of this development, an extensive set of geotechnical and seismic investigations was conducted at three reference sites. Together, the engineering model and guidelines provide the means to select and assess the seismic suitability of a site

Future aerospace ground test facility requirements for the Arnold Engineering Development Center

Science.gov (United States)

Kirchner, Mark E.; Baron, Judson R.; Bogdonoff, Seymour M.; Carter, Donald I.; Couch, Lana M.; Fanning, Arthur E.; Heiser, William H.; Koff, Bernard L.; Melnik, Robert E.; Mercer, Stephen C.

1992-01-01

Arnold Engineering Development Center (AEDC) was conceived at the close of World War II, when major new developments in flight technology were presaged by new aerodynamic and propulsion concepts. During the past 40 years, AEDC has played a significant part in the development of many aerospace systems. The original plans were extended through the years by some additional facilities, particularly in the area of propulsion testing. AEDC now has undertaken development of a master plan in an attempt to project requirements and to plan for ground test and computational facilities over the coming 20 to 30 years. This report was prepared in response to an AEDC request that the National Research Council (NRC) assemble a committee to prepare guidance for planning and modernizing AEDC facilities for the development and testing of future classes of aerospace systems as envisaged by the U.S. Air Force.

Impact of anthropogenic development on coastal ground-water hydrology in southeastern Florida, 1900-2000

Science.gov (United States)

Renken, Robert A.; Dixon, Joann; Koehmstedt, John A.; Ishman, Scott; Lietz, A.C.; Marella, Richard L.; Telis, Pamela A.; Rodgers, Jeff; Memberg, Steven

2005-01-01

Southeastern Florida is an area that has been subject to widely conflicting anthropogenic stress to the Everglades and coastal ecosystems. This stress is a direct consequence of the 20th century economic competition for limited land and water resources needed to satisfy agricultural development and its expansion, its displacement by burgeoning urban development, and the accompanying growth of the limestone mining industry. The development of a highly controlled water-management system designed to reclaim land for urban and agricultural development has severely impacted the extent, character, and vitality of the historic Everglades and coastal ecosystems. An extensive conveyance system of canals, levees, impoundments, surface- water control structures, and numerous municipal well fields are used to sustain the present-day Everglades hydrologic system, prevent overland flow from moving eastward and flooding urban and agricultural areas, maintain water levels to prevent saltwater intrusion, and provide an adequate water supply. Extractive mining activities expanded considerably in the latter part of the 20th century, largely in response to urban construction needs. Much of the present-day urban-agricultural corridor of southeastern Florida lies within an area that is no more than 15 feet above NGVD 1929 and formerly characterized by freshwater marsh, upland, and saline coastal wetland ecosystems. Miami- Dade, Broward, and Palm Beach Counties have experienced explosive population growth, increasing from less than 4,000 inhabitants in 1900 to more than 5 million in 2000. Ground-water use, the principal source of municipal supply, has increased from about 65 Mgal/d (million gallons per day) obtained from 3 well fields in 1930 to more than 770 Mgal/d obtained from 65 well fields in 1995. Water use for agricultural supply increased from 505 Mgal/d in 1953 to nearly 1,150 Mgal/d in 1988, but has since declined to 764 Mgal/d in 1995, partly as a result of displacement of the

[Premorbid stage in the development of anxiety in children].

Science.gov (United States)

Savost'ianova, O L

2002-01-01

The peculiarities of premorbid stage in children, aged 5-15 years, with ICD-10 diagnosis of anxiety-phobic disorders have been studied. The patient's mental state has been described earlier (Savostyanova, 2001). Retrospective evaluation of the patient's state in premorbid allowed to detect the disturbances in personality formation, anxiety phobic reactions and autochthon phases, represented by continuum of subclinical disorders, from floating anxiety to the signs of vital anxiety. These traits are distinguished by instability and inconsistency as well as by mild expression, which did not reach a level of manifest disorders. Personality of the children, who develop anxiety phobic disorders, may be emotionally labile as well as rigid one inclining to negative effectiveness. Hereditable and environment factors influencing anxiety phobic disorders development were detected. The premorbid traits are concluded to reflect inherited anxiety diathesis, which determines the peculiarities of reaction to negative environment and results not only in personality development but also in the large spectrum of future anxiety phobic symptoms.

Development of a Ground Test and Analysis Protocol to Support NASA's NextSTEP Phase 2 Habitation Concepts

Science.gov (United States)

Beaton, Kara H.; Chappell, Steven P.; Bekdash, Omar S.; Gernhardt, Michael L.

2018-01-01

The NASA Next Space Technologies for Exploration Partnerships (NextSTEP) program is a public-private partnership model that seeks commercial development of deep space exploration capabilities to support extensive human spaceflight missions around and beyond cislunar space. NASA first issued the Phase 1 NextSTEP Broad Agency Announcement to U.S. industries in 2014, which called for innovative cislunar habitation concepts that leveraged commercialization plans for low Earth orbit. These habitats will be part of the Deep Space Gateway (DSG), the cislunar space station planned by NASA for construction in the 2020s. In 2016, Phase 2 of the NextSTEP program selected five commercial partners to develop ground prototypes. A team of NASA research engineers and subject matter experts have been tasked with developing the ground test protocol that will serve as the primary means by which these Phase 2 prototype habitats will be evaluated. Since 2008, this core test team has successfully conducted multiple spaceflight analog mission evaluations utilizing a consistent set of operational products, tools, methods, and metrics to enable the iterative development, testing, analysis, and validation of evolving exploration architectures, operations concepts, and vehicle designs. The purpose of implementing a similar evaluation process for the NextSTEP Phase 2 Habitation Concepts is to consistently evaluate the different commercial partner ground prototypes to provide data-driven, actionable recommendations for Phase 3.

[Development of a staging classification for leisure activities and social communication in dependent elderly persons].

Science.gov (United States)

Okochi, Jiro; Takamuku, Kiyoshi; Higashi, Kentaro; Orimo, Kenichiro; Honma, Tatsuya; Nishiwaki, Keiko; Ando, Shigeru

2014-01-01

The aim of this study was to develop a simple staging classification to measure leisure activity and social communication among the elderly at geriatric health care facilities. In order to construct a staging scale for measuring the participation of the elderly subjects, we developed a list of 28 items for three domains: leisure activities, social participation and communication. Data were obtained from users of institutional and day care services at geriatric health service facilities. The Rasch model was applied to test the degree of item fit and difficulty. Simple staging scales were constructed based on 12 leisure activity and nine social communication items. The validity and reliability were tested using these newly developed scales according to the Rasch model and assessments of the test-retest reliability. The participants were 3,458 elderly persons, of whom 1,560 were currently using institutional services and 1,898 were using day care services. Among the 28 items, "traveling" was identified as the most difficult and "watching television" was identified as the easiest. Because items related to "social participation," such as volunteer activities, exhibited a low frequency, they were not used in the further analyses. Simple staging scales were constructed by analyzing the remaining items of leisure activities and social communication according to the Rasch model. The thresholds within the scales were determined in order of item difficulty. Cohen's kappa, as assessed by two different evaluators, was 0.75 for leisure activities and 0.77 for social communication. In this study, we developed staging scales for leisure activity and social communication. The construct validity and test-retest reliability were adequate for both scales. Service providers can improve service quality by using these scales for individual case management of elderly persons in conjunction with existing scales of activities of daily living.

Identification of resonant earthquake ground motion

Indian Academy of Sciences (India)

Resonant ground motion has been observed in earthquake records measured at several parts of the world. This class of ground motion is characterized by its energy being contained in a narrow frequency band. This paper develops measures to quantify the frequency content of the ground motion using the entropy ...

Method of development force at the young gymnasts on the stages of initial and specialized preparation

Directory of Open Access Journals (Sweden)

Khudolii O.N.

2010-08-01

Full Text Available The terms of effective development of force are considered for young gymnasts on the stages of initial and specialized preparation. The models of urgent and moved aside training effect of the power loadings are certain for young gymnasts 7-13 years. It is set that the process of power preparation of young gymnasts can be separate on two stages. On the first stage by means of the concentrated power loadings the expressed decline of force of group of muscles is arrived at. On the second stage by means of favourable a display maximal efforts of loadings the increase of force of group of muscles is arrived at. Application of the power loadings of different orientation is given by possibility during 10-12 employments on 30-60% to increase force of group of muscles, shorten time of training on development of force in two times.

Stage-related expression of mRNAs during pollen development in lily and tobacco.

Science.gov (United States)

Schrauwen, J A; de Groot, P F; van Herpen, M M; van der Lee, T; Reynen, W H; Weterings, K A; Wullems, G J

1990-09-01

Homogeneous populations of developing microspores and pollen from anthers of lily (Lilium longiflorum Thumb.) and tobacco (Nicotiana tabacum L.) show a continuous production of biomass, reaching a maximum in young pollen. The rate of RNA synthesis was 460 fg · h(-1) in young binucleate cells, 138 fg · h(-1) in late binucleate cells and 56 fg · h(-1) in microspores. The mRNA population in developing pollen can be separated into three groups. In the first group, certain types of mRNAs are present at a constant level during all stages of development. A second group is characteristic of young pollen and increases quantitatively until anthesis. A third group is seen transiently; to this belong mRNAs present only before mitosis or at a distinct cell stage after mitosis. Some of the translation products of this latter group of mRNAs showed similarities between lily and tobacco on two-dimensional gels in respect of molecular weight and isolectric point, indicating that those mRNAs and proteins play a role in the regulation of pollen development.

Development of new geomagnetic storm ground response scaling factors for utilization in hazard assessments

Science.gov (United States)

Pulkkinen, A. A.; Bernabeu, E.; Weigel, R. S.; Kelbert, A.; Rigler, E. J.; Bedrosian, P.; Love, J. J.

2017-12-01

Development of realistic storm scenarios that can be played through the exposed systems is one of the key requirements for carrying out quantitative space weather hazards assessments. In the geomagnetically induced currents (GIC) and power grids context, these scenarios have to quantify the spatiotemporal evolution of the geoelectric field that drives the potentially hazardous currents in the system. In response to the Federal Energy Regulatory Commission (FERC) order 779, a team of scientists and engineers that worked under the auspices of North American Electric Reliability Corporation (NERC), has developed extreme geomagnetic storm and geoelectric field benchmark(s) that use various scaling factors that account for geomagnetic latitude and ground structure of the locations of interest. These benchmarks, together with the information generated in the National Space Weather Action Plan, are the foundation for the hazards assessments that the industry will be carrying out in response to the FERC order and under the auspices of the National Science and Technology Council. While the scaling factors developed in the past work were based on the best available information, there is now significant new information available for parts of the U.S. pertaining to the ground response to external geomagnetic field excitation. The significant new information includes the results magnetotelluric surveys that have been conducted over the past few years across the contiguous US and results from previous surveys that have been made available in a combined online database. In this paper, we distill this new information in the framework of the NERC benchmark and in terms of updated ground response scaling factors thereby allowing straightforward utilization in the hazard assessments. We also outline the path forward for improving the overall extreme event benchmark scenario(s) including generalization of the storm waveforms and geoelectric field spatial patterns.

An automated technique to stage lower third molar development on panoramic radiographs for age estimation: a pilot study.

Science.gov (United States)

De Tobel, J; Radesh, P; Vandermeulen, D; Thevissen, P W

2017-12-01

Automated methods to evaluate growth of hand and wrist bones on radiographs and magnetic resonance imaging have been developed. They can be applied to estimate age in children and subadults. Automated methods require the software to (1) recognise the region of interest in the image(s), (2) evaluate the degree of development and (3) correlate this to the age of the subject based on a reference population. For age estimation based on third molars an automated method for step (1) has been presented for 3D magnetic resonance imaging and is currently being optimised (Unterpirker et al. 2015). To develop an automated method for step (2) based on lower third molars on panoramic radiographs. A modified Demirjian staging technique including ten developmental stages was developed. Twenty panoramic radiographs per stage per gender were retrospectively selected for FDI element 38. Two observers decided in consensus about the stages. When necessary, a third observer acted as a referee to establish the reference stage for the considered third molar. This set of radiographs was used as training data for machine learning algorithms for automated staging. First, image contrast settings were optimised to evaluate the third molar of interest and a rectangular bounding box was placed around it in a standardised way using Adobe Photoshop CC 2017 software. This bounding box indicated the region of interest for the next step. Second, several machine learning algorithms available in MATLAB R2017a software were applied for automated stage recognition. Third, the classification performance was evaluated in a 5-fold cross-validation scenario, using different validation metrics (accuracy, Rank-N recognition rate, mean absolute difference, linear kappa coefficient). Transfer Learning as a type of Deep Learning Convolutional Neural Network approach outperformed all other tested approaches. Mean accuracy equalled 0.51, mean absolute difference was 0.6 stages and mean linearly weighted kappa was

Development of a nomogram combining clinical staging with 18F-FDG PET/CT image features in non-small-cell lung cancer stage I-III

International Nuclear Information System (INIS)

Desseroit, Marie-Charlotte; Visvikis, Dimitris; Majdoub, Mohamed; Hatt, Mathieu; Tixier, Florent; Perdrisot, Remy; Cheze Le Rest, Catherine; Guillevin, Remy

2016-01-01

Our goal was to develop a nomogram by exploiting intratumour heterogeneity on CT and PET images from routine 18 F-FDG PET/CT acquisitions to identify patients with the poorest prognosis. This retrospective study included 116 patients with NSCLC stage I, II or III and with staging 18 F-FDG PET/CT imaging. Primary tumour volumes were delineated using the FLAB algorithm and 3D Slicer trademark on PET and CT images, respectively. PET and CT heterogeneities were quantified using texture analysis. The reproducibility of the CT features was assessed on a separate test-retest dataset. The stratification power of the PET/CT features was evaluated using the Kaplan-Meier method and the log-rank test. The best standard metric (functional volume) was combined with the least redundant and most prognostic PET/CT heterogeneity features to build the nomogram. PET entropy and CT zone percentage had the highest complementary values with clinical stage and functional volume. The nomogram improved stratification amongst patients with stage II and III disease, allowing identification of patients with the poorest prognosis (clinical stage III, large tumour volume, high PET heterogeneity and low CT heterogeneity). Intratumour heterogeneity quantified using textural features on both CT and PET images from routine staging 18 F-FDG PET/CT acquisitions can be used to create a nomogram with higher stratification power than staging alone. (orig.)

[Characteristics of ground-dwelling soil macro-arthropod communities in a biodiversity monitoring plot of black soil cropland, northeastern China].

Science.gov (United States)

Liu, Jie; Gao, Mie Xiang; Wu, Dong Hui

2017-12-01

Agro-ecosystem is an important component of terrestrial ecosystems and it is one of the key areas of global ecological and environmental studies. A 16 hm 2 permanent plot in black soil cropland was built to study the community structure of soil biodiversity in typical black soil region in Northeast China. Pitfall trap was used to investigate the ground-dwelling soil macro-arthropods from August to October 2015 in accordance with the three crop growth stages: whirling stage, silking stage, and milk stage. A total of 5284 ground-dwelling soil macro-arthropods belonging to 47 species were captured sorted into 3 classes, 12 orders, 32 families. 3 dominant groups and 11 common groups were found. Phytophages and Omnivores were dominant groups. The individuals and species numbers of ground-dwelling soil macro-arthropods had significant changes with the vegetative growth period. The maximum values of the Shannon index, Margalef index, Pielou index of soil macro-arthropods all appeared in September, but the maximum dominant index appeared in August. From the variation coefficient (CV) and spatial interpolation of different species, it could be seen that there was heterogeneity in the horizontal direction of the ground-dwelling soil macro-arthropod communities. Regarding the relationships between the ground-dwelling soil macro-arthropod communities and soil environmental factors including soil pH, soil organic matter, total nitrogen and soil water content, the bivariate correlation analysis showed there was no significant correlation between them. Results of canonical correspondence analysis (CCA) further indicated that the dominant and common groups were adaptable to environmental factors and widely distributed in the study area. The results showed that the species richness of ground-dwelling soil macro-arthropods was very high in cropland, and the dynamic of soil arthropod's composition and spatial distribution pattern in diffe-rent crop growth stages were significantly

Transcriptome analysis of pecan seeds at different developing stages and identification of key genes involved in lipid metabolism.

Science.gov (United States)

Xu, Zheng; Ni, Jun; Shah, Faheem Afzal; Wang, Qiaojian; Wang, Zhaocheng; Wu, Lifang; Fu, Songling

2018-01-01

Pecan is an economically important nut crop tree due to its unique texture and flavor properties. The pecan seed is rich of unsaturated fatty acid and protein. However, little is known about the molecular mechanisms of the biosynthesis of fatty acids in the developing seeds. In this study, transcriptome sequencing of the developing seeds was performed using Illumina sequencing technology. Pecan seed embryos at different developmental stages were collected and sequenced. The transcriptomes of pecan seeds at two key developing stages (PA, the initial stage and PS, the fast oil accumulation stage) were also compared. A total of 82,155 unigenes, with an average length of 1,198 bp from seven independent libraries were generated. After functional annotations, we detected approximately 55,854 CDS, among which, 2,807 were Transcription Factor (TF) coding unigenes. Further, there were 13,325 unigenes that showed a 2-fold or greater expression difference between the two groups of libraries (two developmental stages). After transcriptome analysis, we identified abundant unigenes that could be involved in fatty acid biosynthesis, degradation and some other aspects of seed development in pecan. This study presents a comprehensive dataset of transcriptomic changes during the seed development of pecan. It provides insights in understanding the molecular mechanisms responsible for fatty acid biosynthesis in the seed development. The identification of functional genes will also be useful for the molecular breeding work of pecan.

TFTR grounding scheme and ground-monitor system

International Nuclear Information System (INIS)

Viola, M.

1983-01-01

The Tokamak Fusion Test Reactor (TFTR) grounding system utilizes a single-point ground. It is located directly under the machine, at the basement floor level, and is tied to the building perimeter ground. Wired to this single-point ground, via individual 500 MCM insulated cables, are: the vacuum vessel; four toroidal field coil cases/inner support structure quadrants; umbrella structure halves; the substructure ring girder; radial beams and columns; and the diagnostic systems. Prior to the first machine operation, a ground-loop removal program was initiated. It required insulation of all hangers and supports (within a 35-foot radius of the center of the machine) of the various piping, conduits, cable trays, and ventilation systems. A special ground-monitor system was designed and installed. It actively monitors each of the individual machine grounds to insure that there are no inadvertent ground loops within the machine structure or its ground and that the machine grounds are intact prior to each pulse. The TFTR grounding system has proven to be a very manageable system and one that is easy to maintain

Development and validation of a clinically applicable score to classify cachexia stages in advanced cancer patients

Science.gov (United States)

Zhou, Ting; Wang, Bangyan; Liu, Huiquan; Yang, Kaixiang; Thapa, Sudip; Zhang, Haowen; Li, Lu

2018-01-01

Abstract Background Cachexia is a multifactorial syndrome that is highly prevalent in advanced cancer patients and leads to progressive functional impairments. The classification of cachexia stages is essential for diagnosing and treating cachexia. However, there is a lack of simple tools with good discrimination for classifying cachexia stages. Therefore, our study aimed to develop a clinically applicable cachexia staging score (CSS) and validate its discrimination of clinical outcomes for different cachexia stages. Methods Advanced cancer patients were enrolled in our study. A CSS comprising the following five components was developed: weight loss, a simple questionnaire of sarcopenia (SARC‐F), Eastern Cooperative Oncology Group, appetite loss, and abnormal biochemistry. According to the CSS, patients were classified into non‐cachexia, pre‐cachexia, cachexia, and refractory cachexia stages, and clinical outcomes were compared among the four groups. Results Of the 297 participating patients, data from 259 patients were ultimately included. Based on the CSS, patients were classified into non‐cachexia (n = 69), pre‐cachexia (n = 68), cachexia (n = 103), and refractory cachexia (n = 19) stages. Patients with more severe cachexia stages had lower skeletal muscle indexes (P = 0.002 and P = 0.004 in male and female patients, respectively), higher prevalence of sarcopenia (P = 0.017 and P = 0.027 in male and female patients, respectively), more severe symptom burden (P cachexia stages. This score is extremely useful for the clinical treatment and prognosis of cachexia and for designing clinical trials. PMID:29372594

Breeders’ work after cultivar development - the stage of recommendation

Directory of Open Access Journals (Sweden)

Luiz Carlos Federizzi

2012-12-01

Full Text Available The development of new cultivars is the ultimate goal of breeding programs and is the result of many years of hard work and dedication of breeders and their teams. An important part of the process, often neglected by geneticists, is the stage from recommendation to the production of breeder seed (post-breeding. This paper discusses the role of the breeder in the recommendation, registration, protection and marketing of new cultivars. The breeder’s active participation in all phases of post-breeding is fundamental to ensure that the cultivar reaches farmers quickly and can provide the benefits expected by society

Comparative proteomic analysis of a high-tillering dwarf mutant induced by spaceflight at different tillering stages

International Nuclear Information System (INIS)

Wang Wei; Wei Lijun; Wang Junmin; Xu Jianlong; Sun Yeqing

2011-01-01

To investigate changes of proteins during rice tiller development, a comparative proteomic analysis between a high-tillering dwarf mutant R955 induced by spaceflight and its ground control was performed at three developmental stages during the vegetative growth, i. e. at days 14 (no tiller appearance), 21 (initial tillering) and 55 (maximum tillering) after sowing. Analysis of the protein spots on two-dimensional fluorescence difference gel electrophoresis 2-D DIGE images revealed 97 proteins that were differentially expressed at the three stages. Among them, 59 unique proteins were successfully identified by mass spectrometry. Through functional and quantitative analysis of proteomic data, it was found that biological processes including energy pathway, photosynthesis, protein metabolism, nitrogen assimilation, amino acid metabolism and stimulus response were mainly involved in tiller development in mutant plant. K-means clustering revealed that proteins regulated at different stages tended to be involved in different biological processes. Two-way analysis of variance (Two-way ANOVA) showed that S-like was directly correlated RNase with the high-tillering ability. (authors)

Syntheses of nucleic acid and protein in somatic embryos of Fritillaria ussuriensis maxim in different development stages

International Nuclear Information System (INIS)

Wang Shuyu; Tang Wei; Wang Hui

1993-09-01

After developing a procedure for somatic embryogenesis in Fritillaria ussuriensis, dynamics on the syntheses of DNA, RNA, and protein during globular, heart-shaped, torpedo-shaped, cotyledonary, and mature somatic embryo stages was demonstrated by both autoradiography and scintillation counting. The rates of syntheses of DNA, RNA, and protein gradually increase between the globular and cotyledonary somatic embryos stages. DNA, RNA, and protein synthesis rates are in peak at the cotyledonary later stage, precotyledonary stage, and cotyledonary stage, respectively. It appears that more DNA, RNA, and protein are synthesized in the cotyledonary somatic embryo stage than in other stages. All these results indicate that an increased syntheses of DNA, RNA, and protein is associated with the differentiation of embryogenic cells and organogenesis in somatic embryos

Advanced Software Ground Station and UAV Development for NLoS Control Using Mobile Communications

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Amr AbdElHamid

2015-01-01

Full Text Available Over the last decades, Unmanned Aerial Systems (UASs have gained much attention due to their various applications in different sections. However, their communication range is limited to utilized communication equipment. Therefore, utilization of GSM channels opens a new prospect towards long distance UAV missions and mobile command and control centers. This paper demonstrates new design and development of a small-scale UAV and a Ground Control Station (GCS using GSM bidirectional communications for Non-Line of Sight (NLoS long range control. GCSs are considered the front end node in UAV guidance process. Therefore, the proposed GCS employs a two-layer framework to consider all ground pilot requirements. Moreover, a new exploitation of global weather forecast data is added to the GCS. On the other hand, the proposed airborne system utilizes a new integration of different Commercial off-the-Shelf (COTS components and excludes short range receivers. The ground and flight tests show that stable bidirectional GSM communication is established, reliable hardware integration is accomplished, real time performance is achieved, GCS functional fidelity is obtained, and low cost is maintained. Finally, some qualitative aspects of the proposed platform are presented to address the detailed features.

The Development of Videos in Culturally Grounded Drug Prevention for Rural Native Hawaiian Youth

Science.gov (United States)

Okamoto, Scott K.; Helm, Susana; McClain, Latoya L.; Dinson, Ay-Laina

2012-01-01

The purpose of this study was to adapt and validate narrative scripts to be used for the video components of a culturally grounded drug prevention program for rural Native Hawaiian youth. Scripts to be used to film short video vignettes of drug-related problem situations were developed based on a foundation of pre-prevention research funded by the…

A Study on the Improvement Effect and Field Applicability of the Deep Soft Ground by Ground Heating Method

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Mincheol Park

2018-05-01

Full Text Available The soft ground in coastal areas should be treated when it needs to be used for the sustainably developed of urban or industrial complex constructions. The ground heating method for soft ground improvement was applied in Eastern Europe in the 1960s, but it was not widely used due to economic and environmental problems. The author developed a device for improving soft ground using an electric heating pipe. This paper investigates the improvement effect and field application of deep soft ground by the ground heating method using the electric heating pipe. Ground heating increases the temperature of the deep soft ground and increases the tip resistance of the static electronic piezo-cone penetration test. Additionally, the pressure of the pore water decreases because the pore water is evaporated due to the ground heating. As a result of the experiment, it was verified that there was an improvement in the effect of deep soft ground by the ground heating method. With ground heating for 96 h, the tip resistance was increased by 61% at a point 0.35 m horizontally away from the electric heat pipe, 22% at 0.97 m, and 2% at 1.31 m. As a result of the field test, it was found that there were no problems in the power supply of the diesel generator and the control panel. It was easy to install the electric heating pipes in the deep soft ground. However, due to boring, the ground was disturbed and water vapor was discharged through this gap. To minimize the discharge of water vapor, it is necessary to drive the electric heating pipe.

BEHAVIOUR OF BACKFILL MATERIALS FOR ELECTRICAL GROUNDING SYSTEMS UNDER HIGH VOLTAGE CONDITIONS

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S. C. LIM

2015-06-01

Full Text Available Backfill materials like Bentonite and cement are effective in lowering grounding resistance of electrodes for a considerable period. During lightning, switching impulses and earth fault occurrences in medium and high voltage networks, the grounding system needs to handle extremely high currents either for a short duration or prolonged period respectively. This paper investigates the behaviour of bentonite, cement and sand under impulse and alternating high voltage (50Hz conditions. Fulguritic-formation was observed in all materials under alternating high voltage. The findings reveal that performance of grounding systems under high voltage conditions may significantly change from the outcomes anticipated at design stage.

Preparing for Mars: The Evolvable Mars Campaign 'Proving Ground' Approach

Science.gov (United States)

Bobskill, Marianne R.; Lupisella, Mark L.; Mueller, Rob P.; Sibille, Laurent; Vangen, Scott; Williams-Byrd, Julie

2015-01-01

As the National Aeronautics and Space Administration (NASA) prepares to extend human presence beyond Low Earth Orbit, we are in the early stages of planning missions within the framework of an Evolvable Mars Campaign. Initial missions would be conducted in near-Earth cis-lunar space and would eventually culminate in extended duration crewed missions on the surface of Mars. To enable such exploration missions, critical technologies and capabilities must be identified, developed, and tested. NASA has followed a principled approach to identify critical capabilities and a "Proving Ground" approach is emerging to address testing needs. The Proving Ground is a period subsequent to current International Space Station activities wherein exploration-enabling capabilities and technologies are developed and the foundation is laid for sustained human presence in space. The Proving Ground domain essentially includes missions beyond Low Earth Orbit that will provide increasing mission capability while reducing technical risks. Proving Ground missions also provide valuable experience with deep space operations and support the transition from "Earth-dependence" to "Earth-independence" required for sustainable space exploration. A Technology Development Assessment Team identified a suite of critical technologies needed to support the cadence of exploration missions. Discussions among mission planners, vehicle developers, subject-matter-experts, and technologists were used to identify a minimum but sufficient set of required technologies and capabilities. Within System Maturation Teams, known challenges were identified and expressed as specific performance gaps in critical capabilities, which were then refined and activities required to close these critical gaps were identified. Analysis was performed to identify test and demonstration opportunities for critical technical capabilities across the Proving Ground spectrum of missions. This suite of critical capabilities is expected to

The Process of Social Identity Development in Adolescent High School Choral Singers: A Grounded Theory

Science.gov (United States)

Parker, Elizabeth Cassidy

2014-01-01

The purpose of this grounded theory study was to describe the process of adolescent choral singers' social identity development within three midsized, midwestern high school mixed choirs. Forty-nine interviews were conducted with 36 different participants. Secondary data sources included memoing, observations, and interviews with the choir…

Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods, Stage 18

International Nuclear Information System (INIS)

Pazsit, Imre; Nam, Tran Hoai; Dykin, Victor; Jonsson, Anders

2013-01-01

This report constitutes Stage 18 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. The objective of the research program is to contribute to the strategic research goal of competence and research capacity by building up competence within the Department of Nuclear Engineering at Chalmers University of Technology, regarding reactor physics, reactor dynamics and noise diagnostics. The purpose is also to contribute to the research goal of giving a basis for SSM's supervision by developing methods for identification and localization of perturbations in reactor cores. Results up to Stage 17 were reported in SKI and SSM reports, as listed in the report's summary

Simulation of ground-water flow and land subsidence in the Antelope Valley ground-water basin, California

Science.gov (United States)

Leighton, David A.; Phillips, Steven P.

2003-01-01

Antelope Valley, California, is a topographically closed basin in the western part of the Mojave Desert, about 50 miles northeast of Los Angeles. The Antelope Valley ground-water basin is about 940 square miles and is separated from the northern part of Antelope Valley by faults and low-lying hills. Prior to 1972, ground water provided more than 90 percent of the total water supply in the valley; since 1972, it has provided between 50 and 90 percent. Most ground-water pumping in the valley occurs in the Antelope Valley ground-water basin, which includes the rapidly growing cities of Lancaster and Palmdale. Ground-water-level declines of more than 200 feet in some parts of the ground-water basin have resulted in an increase in pumping lifts, reduced well efficiency, and land subsidence of more than 6 feet in some areas. Future urban growth and limits on the supply of imported water may continue to increase reliance on ground water. To better understand the ground-water flow system and to develop a tool to aid in effectively managing the water resources, a numerical model of ground-water flow and land subsidence in the Antelope Valley ground-water basin was developed using old and new geohydrologic information. The ground-water flow system consists of three aquifers: the upper, middle, and lower aquifers. The aquifers, which were identified on the basis of the hydrologic properties, age, and depth of the unconsolidated deposits, consist of gravel, sand, silt, and clay alluvial deposits and clay and silty clay lacustrine deposits. Prior to ground-water development in the valley, recharge was primarily the infiltration of runoff from the surrounding mountains. Ground water flowed from the recharge areas to discharge areas around the playas where it discharged either from the aquifer system as evapotranspiration or from springs. Partial barriers to horizontal ground-water flow, such as faults, have been identified in the ground-water basin. Water-level declines owing to

Develop of a Sweet Cookie with toasted sesame and ground

Directory of Open Access Journals (Sweden)

Dr.C. Aldo Hernández-Monzón

2015-11-01

Full Text Available The sweet cookies nutritionally are rich source of energy and they have great acceptance to world level and the sesame (Sésamum indicum it is of the family of the oleaginous ones that possesses a high quantity of protein and fat where 80% belongs to the fatty polinsaturadas fundamentally linoleic acid, it has high content of calcium and the presence iron, magnesium and zinc, what makes it a functional food. This work had as objective to develop a sweet cookie with addition of toastedsesame and ground with good characteristic sensorial and nutritional. The addition of the toasted sesame and ground it was carried out in dose of 10, 15 and 20% to the formulation of a sweet cookie. The sweet cookies were evaluated by seven trained judges to determine the most appropriate dose according to the general impression of obtained quality. The accepted formulation it was determined humidity, proteins, fat, ashy, calcium, iron, and zinc and texture analysis. The best formulation wasthat of 15% sesame for the obtaining of a product with an acceptability of excellent, a percentage of humidity and typical fat of sweet cookies and high content of proteins and calcium as well as appreciable iron content and zinc. The obtained sweet cookie was characterized sensorial to possess a scent and flavor defined to sesame, good crujencia and harmony among its components, very pleasant hardness and the weight and thickness similar to that of other sweet cookies.

Commissioning of the Ground Test Accelerator RFQ

International Nuclear Information System (INIS)

Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Brown, S.; Connolly, R.; Garnett, R.; Gilpatrick, J.D.; Guy, F.W.; Ingalls, W.B.; Little, C.; Lohson, R.A.; Lloyd, S.; Neuschaefer, G.; Power, J.; Saadatmand, K.; Sandoval, D.P.; Stevens, R.R.; Vaughn, G.; Wadlinger, E.A.; Weiss, R.; Yuan, V.

1992-01-01

The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H - beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on-line. The commissioning stages are the 35 key H - injector, the 2.5 MeV Radio Frequency Quadrupole (RFQ), the Intertank Matching Section (IMS), the 3.2 MeV first 2βγ Drift Tube Linac (DTL-1) module, the 8.7 MeV 2βγ DTL (modules 1--5), and the 24 MeV GTA; all 10 DTL modules. Commissioning results from the RFQ beam experiments will be presented along with comparisons to simulations

Commissioning of the ground test accelerator RFQ

International Nuclear Information System (INIS)

Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Brown, S.; Garnott, R.; Gilpatrick, J.D.; Guy, F.W.; Ingalls, W.B.; Little, C.; Lohsen, R.A.; Lloyd, S.; Neuschaefer, G.; Power, J.; Sandoval, D.P.; Saadatmand, K.; Stevens, R.R.Jr.; Vaughn, G.; Wadlinger, E.A.; Yuan, V.; Connolly, R.; Weiss, R.

1992-01-01

The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H - beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on line. The commissioning stages are the 35-keV H - injector, the 2.5-MeV radio-frequency quadrupole (RFQ), the intertank matching section (IMS), the 3.2-MeV first 2-βλ drift tube linac (DTL-1) module, the 8.7-MeV 2-βλDTL (modules 1-5), and the 24-MeV GTA (all 10 DTL modules). Commissioning results from the RFQ beam experiments are presented along with comparisons with simulations. (Author) 8 refs., 9 figs

Transitions in midwestern ground water law

International Nuclear Information System (INIS)

Bowman, J.A.; Clark, G.R.

1989-01-01

The evolution of ground-water law in eight states in the Midwest (Illinois, Indiana, Iowa, Michigan, Minnesota, Missouri, Ohio, and Wisconsin) is examined, and a review of transitions in ground-water doctrines is presented. Two underlying themes in changing ground-water management are communicated. First, ground-water law is evolving from private property rules of capture based on the absolute ownership doctrines to rules requiring conservation and sharing of ground water as a public resource. Second, in both courts and state legislatures, a proactive role of ground-water management is emerging, again, with an emphasis on sharing. Both of these trends are apparent in the Midwest. In the last decade midwestern states have (1) seen significant shifts in court decisions on ground-water use with greater recognition of the reciprocal or mutually dependent nature of ground-water rights, and (2) seen increased legislative development of comprehensive ground-water management statutes that emphasize the reciprocal liabilities of ground-water use. These trends are examined and ground-water management programs discussed for eight states in the Midwest

The longitudinal effects of physical activity and dietary calcium on bone mass accrual across stages of pubertal development.

Science.gov (United States)

Lappe, Joan M; Watson, Patrice; Gilsanz, Vicente; Hangartner, Thomas; Kalkwarf, Heidi J; Oberfield, Sharon; Shepherd, John; Winer, Karen K; Zemel, Babette

2015-01-01

Childhood and adolescence are critical periods of bone mineral content (BMC) accrual that may have long-term consequences for osteoporosis in adulthood. Adequate dietary calcium intake and weight-bearing physical activity are important for maximizing BMC accrual. However, the relative effects of physical activity and dietary calcium on BMC accrual throughout the continuum of pubertal development in childhood remains unclear. The purpose of this study was to determine the effects of self-reported dietary calcium intake and weight-bearing physical activity on bone mass accrual across the five stages of pubertal development in a large, diverse cohort of US children and adolescents. The Bone Mineral Density in Childhood study was a mixed longitudinal study with 7393 observations on 1743 subjects. Annually, we measured BMC by dual-energy X-ray absorptiometry (DXA), physical activity and calcium intake by questionnaire, and pubertal development (Tanner stage) by examination for up to 7 years. Mixed-effects regression models were used to assess physical activity and calcium intake effects on BMC accrual at each Tanner stage. We found that self-reported weight-bearing physical activity contributed to significantly greater BMC accrual in both sexes and racial subgroups (black and nonblack). In nonblack males, the magnitude of the activity effect on total body BMC accrual varied among Tanner stages after adjustment for calcium intake; the greatest difference between high- and low-activity boys was in Tanner stage 3. Calcium intake had a significant effect on bone accrual only in nonblack girls. This effect was not significantly different among Tanner stages. Our findings do not support differential effects of physical activity or calcium intake on bone mass accrual according to maturational stage. The study demonstrated significant longitudinal effects of weight-bearing physical activity on bone mass accrual through all stages of pubertal development. © 2014 American

Profiling microRNA expression during multi-staged date palm (Phoenix dactylifera L.) fruit development

KAUST Repository

Xin, Chengqi; Liu, Wanfei; Lin, Qiang; Zhang, Xiaowei; Cui, Peng; Li, Fusen; Zhang, Guangyu; Pan, Linlin; Al-Amer, Ali; Mei, Hailiang; Al-Mssallem, Ibrahim S.; Hu, Songnian; Al-Johi, Hasan Awad; Yu, Jun

2015-01-01

MicroRNAs (miRNAs) play crucial roles in multiple stages of plant development and regulate gene expression at posttranscriptional and translational levels. In this study, we first identified 238 conserved miRNAs in date palm (Phoenix dactylifera) based on a high-quality genome assembly and defined 78 fruit-development-associated (FDA) miRNAs, whose expression profiles are variable at different fruit development stages. Using experimental data, we subsequently detected 276 novel P. dactylifera-specific FDA miRNAs and predicted their targets. We also revealed that FDA miRNAs function mainly in regulating genes involved in starch/sucrose metabolisms and other carbon metabolic pathways; among them, 221 FDA miRNAs exhibit negative correlation with their corresponding targets, which suggests their direct regulatory roles on mRNA targets. Our data define a comprehensive set of conserved and novel FDA miRNAs along with their expression profiles, which provide a basis for further experimentation in assigning discrete functions of these miRNAs in P. dactylifera fruit development.

Profiling microRNA expression during multi-staged date palm (Phoenix dactylifera L.) fruit development

KAUST Repository

Xin, Chengqi

2015-01-29

MicroRNAs (miRNAs) play crucial roles in multiple stages of plant development and regulate gene expression at posttranscriptional and translational levels. In this study, we first identified 238 conserved miRNAs in date palm (Phoenix dactylifera) based on a high-quality genome assembly and defined 78 fruit-development-associated (FDA) miRNAs, whose expression profiles are variable at different fruit development stages. Using experimental data, we subsequently detected 276 novel P. dactylifera-specific FDA miRNAs and predicted their targets. We also revealed that FDA miRNAs function mainly in regulating genes involved in starch/sucrose metabolisms and other carbon metabolic pathways; among them, 221 FDA miRNAs exhibit negative correlation with their corresponding targets, which suggests their direct regulatory roles on mRNA targets. Our data define a comprehensive set of conserved and novel FDA miRNAs along with their expression profiles, which provide a basis for further experimentation in assigning discrete functions of these miRNAs in P. dactylifera fruit development.

Rethinking the Food and Drug Administration's 2013 guidance on developing drugs for early-stage Alzheimer's disease.

Science.gov (United States)

Schneider, Lon S

2014-03-01

The February 2013 Food and Drug Administration (FDA) draft guidance for developing drugs for early-stage Alzheimer's disease (AD) creates certain challenges as they guide toward the use of one cognitive outcome to gain accelerated marketing approval for preclinical AD drugs, and a composite clinical scale - the Clinical Dementia Rating Scale in particular - for the primary outcome for prodromal AD clinical trials. In light of the developing knowledge regarding early stage diagnoses and clinical trials outcomes, we recommend that FDA describe its requirements for validating preclinical AD diagnoses for drug development purposes, maintain the principle for requiring coprimary outcomes, and encourage the advancement of outcomes for early stage AD trials. The principles for drug development for early stage AD should not differ from those for clinical AD, especially as the diagnoses of prodromal and early AD impinge on each other. The FDA should not recommend that a composite scale be used as a sole primary efficacy outcome to support a marketing claim unless it requires that the cognitive and functional components of such a scale are demonstrated to be individually meaningful. The current draft guidelines may inadvertently constrain efforts to better assess the clinical effects of new drugs and inhibit innovation in an area where evidence-based clinical research practices are still evolving. Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Reassessment of Ground-Water Recharge and Simulated Ground-Water Availability for the Hawi Area of North Kohala, Hawaii

Science.gov (United States)

Oki, Delwyn S.

2002-01-01

An estimate of ground-water availability in the Hawi area of north Kohala, Hawaii, is needed to determine whether ground-water resources are adequate to meet future demand within the area and other areas to the south. For the Hawi area, estimated average annual recharge from infiltration of rainfall, fog drip, and irrigation is 37.5 million gallons per day from a daily water budget. Low and high annual recharge estimates for the Hawi area that incorporate estimated uncertainty are 19.9 and 55.4 million gallons per day, respectively. The recharge estimates from this study are lower than the recharge of 68.4 million gallons per day previously estimated from a monthly water budget. Three ground-water models, using the low, intermediate, and high recharge estimates (19.9, 37.5, and 55.4 million gallons per day, respectively), were developed for the Hawi area to simulate ground-water levels and discharges for the 1990?s. To assess potential ground-water availability, the numerical ground-water flow models were used to simulate the response of the freshwater-lens system to withdrawals at rates in excess of the average 1990?s withdrawal rates. Because of uncertainty in the recharge estimate, estimates of ground-water availability also are uncertain. Results from numerical simulations indicate that for appropriate well sites, depths, and withdrawal rates (1) for the low recharge estimate (19.9 million gallons per day) it may be possible to develop an additional 10 million gallons per day of fresh ground water from the Hawi area and maintain a freshwater-lens thickness of 160 feet near the withdrawal sites, (2) for the intermediate recharge estimate (37.5 million gallons per day) it may be possible to develop an additional 15 million gallons per day of fresh ground water from the Hawi area and maintain a freshwater-lens thickness of 190 feet near the withdrawal sites, and (3) for the high recharge estimate (55.4 million gallons per day) it may be possible to develop at

Integration of a satellite ground support system based on analysis of the satellite ground support domain

Science.gov (United States)

Pendley, R. D.; Scheidker, E. J.; Levitt, D. S.; Myers, C. R.; Werking, R. D.

1994-11-01

This analysis defines a complete set of ground support functions based on those practiced in real space flight operations during the on-orbit phase of a mission. These functions are mapped against ground support functions currently in use by NASA and DOD. Software components to provide these functions can be hosted on RISC-based work stations and integrated to provide a modular, integrated ground support system. Such modular systems can be configured to provide as much ground support functionality as desired. This approach to ground systems has been widely proposed and prototyped both by government institutions and commercial vendors. The combined set of ground support functions we describe can be used as a standard to evaluate candidate ground systems. This approach has also been used to develop a prototype of a modular, loosely-integrated ground support system, which is discussed briefly. A crucial benefit to a potential user is that all the components are flight-qualified, thus giving high confidence in their accuracy and reliability.

The Experiential Model of the Person-Centred Record: a social constructionist grounded theory

OpenAIRE

Mihelcic, Joanne

2017-01-01

The objective of this research was to explore the co-creation of person-centred records, to support memory, identity and personhood, with the person diagnosed with early stage dementia. This thesis describes the design of a second generation grounded theory methodology and applied archival research. With its postmodern, continuum and social constructionist influences second generation grounded theory sees a shift in how we understand the researcher’s interaction with participants in a study...

Oil production at different stages of leaf development in Lippia alba

Directory of Open Access Journals (Sweden)

Diego Pandeló

2012-06-01

Full Text Available The aim of this work was to analyze terpene oil production and terpene synthases (TPS gene expression from leaves at different developmental stages of different chemotypes of Lippia alba (Mill. N.E. Br. ex Britton & P. Wilson, Verbenaceae. Hydro-distilled essential oil were used for chemical analysis and gene expression of three monoterpene synthase genes called LaTPS12, LaTPS23 and LaTPS25 were used for analyses of gene expression associated to oil production. The putative genes were associated to TPS-b gene class. Semi-quantitative PCR and quantitative PCR (qPCR analysis were used to investigate the expression profile of those three putative genes in different leaf stages and different chemotypes. Additionally, total oil production and gene expression of putative TPS genes cloned from L. alba chemotype linalool were evaluated at different stages of leaf development. The expression level of those three genes was higher when the highest oil production was observed, mainly in young leaves at the fourth nodal segment for all evaluated chemotypes. Total oil production was higher at leaves that had unopened trichomes. We also observed that the 1mM of MeJA treatment increased the gene expression in all chemotypes after 24 h elicitation.

Oil production at different stages of leaf development in Lippia alba

Directory of Open Access Journals (Sweden)

Diego Pandeló

2012-01-01

Full Text Available The aim of this work was to analyze terpene oil production and terpene synthases (TPS gene expression from leaves at different developmental stages of different chemotypes of Lippia alba (Mill. N.E. Br. ex Britton & P. Wilson, Verbenaceae. Hydro-distilled essential oil were used for chemical analysis and gene expression of three monoterpene synthase genes called LaTPS12, LaTPS23 and LaTPS25 were used for analyses of gene expression associated to oil production. The putative genes were associated to TPS-b gene class. Semi-quantitative PCR and quantitative PCR (qPCR analysis were used to investigate the expression profile of those three putative genes in different leaf stages and different chemotypes. Additionally, total oil production and gene expression of putative TPS genes cloned from L. alba chemotype linalool were evaluated at different stages of leaf development. The expression level of those three genes was higher when the highest oil production was observed, mainly in young leaves at the fourth nodal segment for all evaluated chemotypes. Total oil production was higher at leaves that had unopened trichomes. We also observed that the 1mM of MeJA treatment increased the gene expression in all chemotypes after 24 h elicitation.

Cryotop vitrification for in vitro produced bovine and buffalo (Bubalus bubalis embryos at different stages of development

Directory of Open Access Journals (Sweden)

B. Gasparrini

2010-02-01

Full Text Available The aim of this study was to evaluate the possibility to vitrify in vitro produced (IVP buffalo and bovine embryos at different stages of development by an advanced version of the “minimal volume approaches”: the Cryotop method. In both experiments, the embryos were vitrified at the tight morula (TM, early blastocyst (eBl, blastocyst (Bl, expanded blastocyst (xBl and, only for buffalo, at the hatched blastocyst (hBl stage. After warming, the embryos were cultured in vitro for 24 hours. Stage of development affected the freezability of IVP embryos of both species with the highest embryo survival rates at advanced stages (xBl=76% and hBl=75% for buffalos and xBl=75% for bovine. These results suggest that Cryotop vitrification is an efficient method for buffalo and bovine IVP embryo cryopreservation.

Development of Ground Coils with Low Eddy Current Loss by Applying the Compression Molding Method after the Coil Winding

Science.gov (United States)

Suzuki, Masao; Aiba, Masayuki; Takahashi, Noriyuki; Ota, Satoru; Okada, Shigenori

In a magnetically levitated transportation (MAGLEV) system, a huge number of ground coils will be required because they must be laid for the whole line. Therefore, stable performance and reduced cost are essential requirements for the ground coil development. On the other hand, because the magnetic field changes when the superconducting magnet passes by, an eddy current will be generated in the conductor of the ground coil and will result in energy loss. The loss not only increases the magnetic resistance for the train running but also brings an increase in the ground coil temperature. Therefore, the reduction of the eddy current loss is extremely important. This study examined ground coils in which both the eddy current loss and temperature increase were small. Furthermore, quantitative comparison for the eddy current loss of various magnet wire samples was performed by bench test. On the basis of the comparison, a round twisted wire having low eddy current loss was selected as an effective ground coil material. In addition, the ground coils were manufactured on trial. A favorable outlook to improve the size accuracy of the winding coil and uneven thickness of molded resin was obtained without reducing the insulation strength between the coil layers by applying a compression molding after winding.

Environmental impact of a nuclear industry at an early stage of development: peculiar aspects

International Nuclear Information System (INIS)

Paschoa, A.S.; Baptista, G.B.

1978-01-01

The environmental impact of a nuclear industry at an early stage of development is examined vis-a-vis the experience accumulated in studies on the environmental impact of the nuclear fuel cycle in a developed country. Differences in the optics of the nuclear industry in a developed country and that of segments of the public opinion are briefly discussed. Some peculiar aspects of a nuclear industry being implanted in a developing nation, including adoption of new legislation and regulations, are presented, taking into account the unusual opportunity to attack potential problems in advance. The unique example of the pre-operational survey of a region surrounding a uranium mine in a developing nation is mentioned as an example of cooperation between the nuclear industry and the scientific community to minimize the environmental impact of uranium mining operations. The potential environmental impact of other stages of the nuclear fuel cycle is also examined. Further cooperation between the nuclear industry and the scientific community of Latin American countries is suggested to minimize the environmental impact of the nuclear fuel cycle in nations starting nuclear programs. (author)

Development and testing of techniques for in-ground stabilization, size reduction, and safe removal of radioactive wastes stored in containments buried in ground

International Nuclear Information System (INIS)

Halliwell, Stephen; Christodoulou, Apostolos

2013-01-01

Since the 1950's radioactive wastes from a number of laboratories have been stored below ground at the Hanford site, Washington State, USA, in vertical pipe units (VPUs) made of five 200 litre drums without tops or bottoms, and in caissons, made out of corrugated pipe, or concrete and typically 2,500 mm in diameter. The VPU's are buried of the order of 2,100 mm below grade, and the caissons are buried of the order of 6,000 mm below grade. The waste contains fuel pieces, fission products, and a range of chemicals used in the laboratory processes. This can include various energetic reactants such as un-reacted sodium potassium (NaK), potassium superoxide (KO 2 ), and picric acid, as well as quantities of other liquids. The integrity of the containments is considered to present unacceptable risks from leakage of radioactivity to the environment. This paper describes the successful development and full scale testing of in-ground augering equipment, grouting systems and removal equipment for remediation and removal of the VPUs, and the initial development work to test the utilization of the same basic augering and grouting techniques for the stabilization, size reduction and removal of caissons. (authors)

Ground Motion Prediction Models for Caucasus Region

Science.gov (United States)

Jorjiashvili, Nato; Godoladze, Tea; Tvaradze, Nino; Tumanova, Nino

2016-04-01

Ground motion prediction models (GMPMs) relate ground motion intensity measures to variables describing earthquake source, path, and site effects. Estimation of expected ground motion is a fundamental earthquake hazard assessment. The most commonly used parameter for attenuation relation is peak ground acceleration or spectral acceleration because this parameter gives useful information for Seismic Hazard Assessment. Since 2003 development of Georgian Digital Seismic Network has started. In this study new GMP models are obtained based on new data from Georgian seismic network and also from neighboring countries. Estimation of models is obtained by classical, statistical way, regression analysis. In this study site ground conditions are additionally considered because the same earthquake recorded at the same distance may cause different damage according to ground conditions. Empirical ground-motion prediction models (GMPMs) require adjustment to make them appropriate for site-specific scenarios. However, the process of making such adjustments remains a challenge. This work presents a holistic framework for the development of a peak ground acceleration (PGA) or spectral acceleration (SA) GMPE that is easily adjustable to different seismological conditions and does not suffer from the practical problems associated with adjustments in the response spectral domain.

Management of ground water using isotope techniques

International Nuclear Information System (INIS)

Romani, Saleem

2004-01-01

Ground water play a major role in national economy and sustenance of life and environment. Prevalent water crisis in India includes falling water table, water quality deterioration, water logging and salinity. Keeping in view the increasing thrust on groundwater resources and the present scenario of availability vis-a vis demand there is a need to reorient our approach to ground water management. The various ground water management options require proper understanding of ground water flow system. Isotopes are increasingly being applied in hydrogeological investigations as a supplementary tool for assessment of aquifer flow and transport characteristics. Isotope techniques coupled with conventional hydrogeological and hydrochemical methods can bring in greater accuracy in the conceptualization of hydrogeological control mechanism. The use of isotope techniques in following areas can certainly be of immense help in implementing various ground water management options in an efficient manner. viz.Interaction between the surface water - groundwater systems to plan conjunctive use of surface and ground water. Establishing hydraulic interconnections between the aquifers in a multi aquifer system. Depth of circulation of water and dating of ground water. Demarcating ground water recharge and discharge areas. Plan ground water development in coastal aquifers to avoid sea water ingress. Development of flood plain aquifer. (author)

Waste recycling: utilization of coffee grounds and kitchen waste in vermicomposting.

Science.gov (United States)

Adi, A J; Noor, Z M

2009-01-01

Vermicomposting using Lumbricus rubellus for 49 days was conducted after 21 days of pre-composting. Three different combination of treatments were prepared with eight replicates for each treatment namely cow dung: kitchen waste in 30:70 ratio (T(1)), cow dung: coffee grounds in 30:70 ratio (T(2)), and cow dung: kitchen waste: coffee grounds in 30:35:35 ratio (T(3)). The multiplication of earthworms in terms of numbers and weight were measured at the end of vermicomposting. Consequently, only T(2) showed significant increase (from it initial stage) compared to other treatments. The presence of coffee grounds in T(2) and T(3) showed higher percentage of nutrient elements in vermicompost produced. The data reveal that coffee grounds can be decomposed through vermicomposting and help to enhance the quality of vermicompost produced rather than sole use of kitchen waste in vermicomposting.

Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine

Science.gov (United States)

Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

2015-01-01

This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design.

Spider assemblages associated with different crop stages of irrigated rice agroecosystems from eastern Uruguay.

Science.gov (United States)

Bao, Leticia; Ginella, Juaquín; Cadenazzi, Mónica; Castiglioni, Enrique A; Martínez, Sebastián; Casales, Luis; Caraballo, María P; Laborda, Álvaro; Simo, Miguel

2018-01-01

The rice crop and associated ecosystems constitute a rich mosaic of habitats that preserve a rich biological diversity. Spiders are an abundant and successful group of natural predators that are considered efficient in the biocontrol of the major insect pests in agroecosystems. Spider diversity in different stages of the rice crop growth from eastern Uruguay was analysed. Field study was developed on six rice farms with rotation system with pasture, installed during intercropping stage as cover crop. Six rice crops distributed in three locations were sampled with pitfall and entomological vaccum suction machine. Sixteen families, representing six guilds, were collected. Lycosidae, Linyphiidae, Anyphaenidae and Tetragnathidae were the most abundant families (26%, 25%, 20% and 12%, respectively) and comprised more than 80% of total abundance. Other hunters (29%), sheet web weavers (25%) and ground hunters (24%) were the most abundant guilds. Species composition along different crop stages was significantly different according to the ANOSIM test. The results showed higher spider abundance and diversity along the crop and intercrop stages. This study represents the first contribution to the knowledge of spider diversity associated with rice agroecosystem in the country.

Two critical periods in early visual cortex during figure-ground segregation

NARCIS (Netherlands)

Wokke, M.E.; Sligte, I.G.; Scholte, H.S.; Lamme, V.A.F.

2012-01-01

.The ability to distinguish a figure from its background is crucial for visual perception. To date, it remains unresolved where and how in the visual system different stages of figure-ground segregation emerge. Neural correlates of figure border detection have consistently been found in early visual

Changes of lysosomes in the earliest stages of the development of atherosclerosis.

Science.gov (United States)

Bobryshev, Yuri V; Shchelkunova, Tatyana A; Morozov, Ivan A; Rubtsov, Petr M; Sobenin, Igor A; Orekhov, Alexander N; Smirnov, Alexander N

2013-05-01

One of hypotheses of atherosclerosis is based on a presumption that the zones prone to the development of atherosclerosis contain lysosomes which are characterized by enzyme deficiency and thus, are unable to dispose of lipoproteins. The present study was undertaken to investigate the characteristics and changes of lysosomes in the earliest stages of the development of atherosclerosis. Electron microscopic immunocytochemistry revealed that there were certain changes in the distribution of CD68 antigen in lysosomes along the 'normal intima-initial lesion-fatty streak' sequence. There were no significant changes found in the key mRNAs encoding for the components of endosome/lysosome compartment in initial atherosclerotic lesions, but in fatty streaks, the contents of EEA1 and Rab5a mRNAs were found to be diminished while the contents of CD68 and p62 mRNAs were increased, compared with the intact tissue. The study reinforces a view that changes occurring in lysosomes play a role in atherogenesis from the very earlier stages of the disease. © 2013 The Authors. Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.

Microbial landscape features in patients with generalized periodontitis at pre-clinical and radiological stage of its development

Directory of Open Access Journals (Sweden)

Vatamanyuk N.V.

2014-11-01

Full Text Available The paper presents the results of a comparative study of microbial landscape features in patients with generalized periodontitis at pre-clinical and radiological stage of its development in 42 patients. The purpose of the study is a comparative study of the composition of microbiocenosis of periodontal tissues in patients with chronic catarrhal gingivitis (CCG and chronic generalized periodontitis (CGP at an early stage of development and development studies of microbiological criteria for early emergence of the destructive process in periodontal structures. We found that the microflora isolated from dento-gingival grooves is of importance in diagnostics to identify the etiology of chronic generalized catarrhal gingivitis (CGCG and chronic generalized periodontitis in the early stages of its development. It was established that the presence of two or more types of fixed parodonto-pathogenic microorganisms in microbial association increases the likelihood of inflammatory and destructive events in periodontal tissues in patients with GCCG and is one of the reasons of is becoming CGP.

Development of advanced air-blown entrained-flow two-stage bituminous coal IGCC gasifier

Directory of Open Access Journals (Sweden)

Abaimov Nikolay A.

2017-01-01

Full Text Available Integrated gasification combined cycle (IGCC technology has two main advantages: high efficiency, and low levels of harmful emissions. Key element of IGCC is gasifier, which converts solid fuel into a combustible synthesis gas. One of the most promising gasifiers is air-blown entrained-flow two-stage bituminous coal gasifier developed by Mitsubishi Heavy Industries (MHI. The most obvious way to develop advanced gasifier is improvement of commercial-scale 1700 t/d MHI gasifier using the computational fluid dynamics (CFD method. Modernization of commercial-scale 1700 t/d MHI gasifier is made by changing the regime parameters in order to improve its cold gas efficiency (CGE and environmental performance, namely H2/CO ratio. The first change is supply of high temperature (900°C steam in gasifier second stage. And the second change is additional heating of blast air to 900°C.

Ground-motion prediction from tremor

Science.gov (United States)

Baltay, Annemarie S.; Beroza, Gregory C.

2013-01-01

The widespread occurrence of tremor, coupled with its frequency content and location, provides an exceptional opportunity to test and improve strong ground-motion attenuation relations for subduction zones. We characterize the amplitude of thousands of individual 5 min tremor events in Cascadia during three episodic tremor and slip events to constrain the distance decay of peak ground acceleration (PGA) and peak ground velocity (PGV). We determine the anelastic attenuation parameter for ground-motion prediction equations (GMPEs) to a distance of 150 km, which is sufficient to place important constraints on ground-motion decay. Tremor PGA and PGV show a distance decay that is similar to subduction-zone-specific GMPEs developed from both data and simulations; however, the massive amount of data present in the tremor observations should allow us to refine distance-amplitude attenuation relationships for use in hazard maps, and to search for regional variations and intrasubduction zone differences in ground-motion attenuation.

Risk identification for quality on stage of pharmaceutical development of combined eye drops for glaucoma treatment

Directory of Open Access Journals (Sweden)

Олександр Миколайович Якубчук

2015-12-01

Full Text Available Aim: To identify the possible risks associated with critical quality attribute of combined eye drops for the treatment of glaucoma using of common risk evaluation methodologies for plannig a drug quality on the stage of pharmaceutical development. Methods: The paper used method of causal analysis. The maximal number of factors has been define to identify potential factors that provide most significant impact on the drug quality and Ishikawa diagram - graphical representation of causes and effects has been built.Results: Analysis allowed to organize the possible factors affecting the drug quality in the generalized categories: quality control methods, medicines and excipients, primary packaging, proper manufacturing conditions and the stage of the process. The most important factors that are carriers of the risk factors and may lead to negative effects have been identified for the generalized categories.Conclusions: Determined at the stage of pharmaceutical development potential critical quality attribute of AFI, excipients and primary packaging, critical parameters of the process, provide a better understanding, reduction and adoption of risk in subsequent stages of the life cycle of the drug

3. SEGMITE International Symposium on Sustainable Development of Surface and Ground Water Resources

International Nuclear Information System (INIS)

Tabrez, A.R.

1999-01-01

The Society of Economic Geologist and Mineral Technologist (SEGMITE), National Institute of Oceanography (NIO) and Association of Geo-scientists for International Development with the collaboration of Export Promotion Bureau, Government of Pakistan has organised this symposium. The third Segmite International Symposium on Sustainable Development of surface and ground water resources was held on 8-10 march 1999 at Karachi, Pakistan. This book gives the conference information, brochure and abstracts of papers presented in the conference. There are about 38 abstracts submitted for the conference and related nature of the materials. Out of these 38 papers 16 are of nuclear oriented which are presented here separately. (A.B.)

PRINCIPLES, STAGES AND OBJECTIVES OF FORMATION OF INNOVATIVE DEVELOPMENT PATTERNS AT CONSTRUCTION ENTERPRISES

Directory of Open Access Journals (Sweden)

Mikhaylov Valeriy Yurevich

2012-10-01

Full Text Available In the article, the results of the research performed in the field of innovative development of enterprises are provided, and the main principles and the content of each stage of innovative development of construction enterprises in the new economic environment are developed on the basis of the research. Actions, proposed in the article, will ensure the implementation of the strategy of innovative development with a view to effective attainment of objectives of case management and successful adaptation of construction enterprises to altering factors of the media.

Life cycle assessment of nanoadsorbents at early stage technological development

DEFF Research Database (Denmark)

Kazemi, Ali; Bahramifar, Nader; Heydari, Akbar

2018-01-01

the process of the functionalization of nanoadsorbents leads to the increase of the adsorption capacity of nanoadsorbents, it is also paired with a significant enhancement of negative environmental impacts. The results of t-test comparing the cradle-to-use life cycle impacts of studied impact categories for 1...... in the control and removal of environmental pollutants. This application is still an emerging technology at the early stages of development. Hence, the heart of this study enables an environmental assessment of nanoadsorbents as an emerging product. In addition, the environmental impacts of synthesized...

Water resources data, Iowa, water year 2001, Volume 2. surface water--Missouri River basin, and ground water

Science.gov (United States)

Nalley, G.M.; Gorman, J.G.; Goodrich, R.D.; Miller, V.E.; Turco, M.J.; Linhart, S.M.

2002-01-01

The Water Resources Division of the U.S. Geological Survey, in cooperation with State, county, municipal, and other Federal agencies, obtains a large amount of data pertaining to the water resources of Iowa each water year. These data, accumulated during many water years, constitute a valuable data base for developing an improved understanding of the water resources of the State. To make this data readily available to interested parties outside of the Geological Survey, the data is published annually in this report series entitled “Water Resources Data - Iowa” as part of the National Water Data System. Water resources data for water year 2001 for Iowa consists of records of stage, discharge, and water quality of streams; stage and contents of lakes and reservoirs; and water levels and water quality of ground water. This report, in two volumes, contains stage or discharge records for 132 gaging stations; stage records for 9 lakes and reservoirs; water-quality records for 4 gaging stations; sediment records for 13 gaging stations; and water levels for 163 ground-water observation wells. Also included are peak-flow data for 92 crest-stage partial-record stations, water-quality data from 86 municipal wells, and precipitation data collected at 6 gaging stations and 2 precipitation sites. Additional water data were collected at various sites not included in the systematic data-collection program, and are published here as miscellaneous measurements and analyses. These data represent that part of the National Water Data System operated by the U.S. Geological Survey and cooperating local, State, and Federal agencies in Iowa.Records of discharge or stage of streams, and contents or stage of lakes and reservoirs were first published in a series of U.S. Geological Survey water-supply papers entitled “Surface Water Supply of the United States.” Through September 30, 1960, these water-supply papers were published in an annual series; during 1961-65 and 1966-70, they

Jean Piaget and Rudolf Steiner: Stages of Child Development and Implications for Pedagogy.

Science.gov (United States)

Ginsburg, Iona H.

1982-01-01

The views of Jean Piaget and Rudolf Steiner concerning children's stages of development are compared and related to present-day instructional practices used in the Waldorf schools, which employ Steiner's ideas. Educational principles and practices used at the elementary school level are discussed. (PP)

Development of a Ground Water Data Portal for Interoperable Data Exchange within the U.S. National Ground Water Monitoring Network and Beyond

Science.gov (United States)

Booth, N. L.; Brodaric, B.; Lucido, J. M.; Kuo, I.; Boisvert, E.; Cunningham, W. L.

2011-12-01

The need for a national groundwater monitoring network within the United States is profound and has been recognized by organizations outside government as a major data gap for managing ground-water resources. Our country's communities, industries, agriculture, energy production and critical ecosystems rely on water being available in adequate quantity and suitable quality. To meet this need the Subcommittee on Ground Water, established by the Federal Advisory Committee on Water Information, created a National Ground Water Monitoring Network (NGWMN) envisioned as a voluntary, integrated system of data collection, management and reporting that will provide the data needed to address present and future ground-water management questions raised by Congress, Federal, State and Tribal agencies and the public. The NGWMN Data Portal is the means by which policy makers, academics and the public will be able to access ground water data through one seamless web-based application from disparate data sources. Data systems in the United States exist at many organizational and geographic levels and differing vocabulary and data structures have prevented data sharing and reuse. The data portal will facilitate the retrieval of and access to groundwater data on an as-needed basis from multiple, dispersed data repositories allowing the data to continue to be housed and managed by the data provider while being accessible for the purposes of the national monitoring network. This work leverages Open Geospatial Consortium (OGC) data exchange standards and information models. To advance these standards for supporting the exchange of ground water information, an OGC Interoperability Experiment was organized among international participants from government, academia and the private sector. The experiment focused on ground water data exchange across the U.S. / Canadian border. WaterML2.0, an evolving international standard for water observations, encodes ground water levels and is exchanged

The Heme Biosynthesis Pathway Is Essential for Plasmodium falciparum Development in Mosquito Stage but Not in Blood Stages*

Science.gov (United States)

Ke, Hangjun; Sigala, Paul A.; Miura, Kazutoyo; Morrisey, Joanne M.; Mather, Michael W.; Crowley, Jan R.; Henderson, Jeffrey P.; Goldberg, Daniel E.; Long, Carole A.; Vaidya, Akhil B.

2014-01-01

Heme is an essential cofactor for aerobic organisms. Its redox chemistry is central to a variety of biological functions mediated by hemoproteins. In blood stages, malaria parasites consume most of the hemoglobin inside the infected erythrocytes, forming nontoxic hemozoin crystals from large quantities of heme released during digestion. At the same time, the parasites possess a heme de novo biosynthetic pathway. This pathway in the human malaria parasite Plasmodium falciparum has been considered essential and is proposed as a potential drug target. However, we successfully disrupted the first and last genes of the pathway, individually and in combination. These knock-out parasite lines, lacking 5-aminolevulinic acid synthase and/or ferrochelatase (FC), grew normally in blood-stage culture and exhibited no changes in sensitivity to heme-related antimalarial drugs. We developed a sensitive LC-MS/MS assay to monitor stable isotope incorporation into heme from its precursor 5-[13C4]aminolevulinic acid, and this assay confirmed that de novo heme synthesis was ablated in FC knock-out parasites. Disrupting the FC gene also caused no defects in gametocyte generation or maturation but resulted in a greater than 70% reduction in male gamete formation and completely prevented oocyst formation in female Anopheles stephensi mosquitoes. Our data demonstrate that the heme biosynthesis pathway is not essential for asexual blood-stage growth of P. falciparum parasites but is required for mosquito transmission. Drug inhibition of pathway activity is therefore unlikely to provide successful antimalarial therapy. These data also suggest the existence of a parasite mechanism for scavenging host heme to meet metabolic needs. PMID:25352601

Evaporation from bare ground with different water-table depths based on an in-situ experiment in Ordos Plateau, China

Science.gov (United States)

Zhang, Zaiyong; Wang, Wenke; Wang, Zhoufeng; Chen, Li; Gong, Chengcheng

2018-03-01

The dynamic processes of ground evaporation are complex and are related to a multitude of factors such as meteorological influences, water-table depth, and materials in the unsaturated zone. To investigate ground evaporation from a homogeneous unsaturated zone, an in-situ experiment was conducted in Ordos Plateau of China. Two water-table depths were chosen to explore the water movement in the unsaturated zone and ground evaporation. Based on the experimental and calculated results, it was revealed that (1) bare ground evaporation is an atmospheric-limited stage for the case of water-table depth being close to the capillary height; (2) the bare ground evaporation is a water-storage-limited stage for the case of water-table depth being beyond the capillary height; (3) groundwater has little effect on ground-surface evaporation when the water depth is larger than the capillary height; and (4) ground evaporation is greater at nighttime than that during the daytime; and (5) a liquid-vapor interaction zone at nearly 20 cm depth is found, in which there exists a downward vapor flux on sunny days, leading to an increasing trend of soil moisture between 09:00 to 17:00; the maximum value is reached at midday. The results of this investigation are useful to further understand the dynamic processes of ground evaporation in arid areas.

Contrast in edge vegetation structure modifies the predation risk of natural ground nests in an agricultural landscape.

Directory of Open Access Journals (Sweden)

Nicole A Schneider

Full Text Available Nest predation risk generally increases nearer forest-field edges in agricultural landscapes. However, few studies test whether differences in edge contrast (i.e. hard versus soft edges based on vegetation structure and height affect edge-related predation patterns and if such patterns are related to changes in nest conspicuousness between incubation and nestling feeding. Using data on 923 nesting attempts we analyse factors influencing nest predation risk at different edge types in an agricultural landscape of a ground-cavity breeding bird species, the Northern Wheatear (Oenanthe oenanthe. As for many other bird species, nest predation is a major determinant of reproductive success in this migratory passerine. Nest predation risk was higher closer to woodland and crop field edges, but only when these were hard edges in terms of ground vegetation structure (clear contrast between tall vs short ground vegetation. No such edge effect was observed at soft edges where adjacent habitats had tall ground vegetation (crop, ungrazed grassland. This edge effect on nest predation risk was evident during the incubation stage but not the nestling feeding stage. Since wheatear nests are depredated by ground-living animals our results demonstrate: (i that edge effects depend on edge contrast, (ii that edge-related nest predation patterns vary across the breeding period probably resulting from changes in parental activity at the nest between the incubation and nestling feeding stage. Edge effects should be put in the context of the nest predator community as illustrated by the elevated nest predation risk at hard but not soft habitat edges when an edge is defined in terms of ground vegetation. These results thus can potentially explain previously observed variations in edge-related nest predation risk.

Airfield Ground Safety

National Research Council Canada - National Science Library

Petrescu, Jon

2000-01-01

.... The system developed under AGS, called the Ground Safety Tracking and Reporting System, uses multisensor data fusion from in-pavement inductive loop sensors to address a critical problem affecting out nation's airports: runway incursions...

Developing an inventor support service which performs early stage market and manufacturing evaluations. Final report

Energy Technology Data Exchange (ETDEWEB)

1991-10-01

American businesses are learning the difficult high cost lesson of ignoring production and market factors (producibility, unit product cost (UPC), marketability, etc) during the engineering design phase of product development. Studies have shown that the Japanese spend three times as long as Americans in the design feasibility and decision process of new product introductions and one third the amount of time in the implementation of those products. There is a 20 to 1 cost benefit on effort applied in the design phase versus the production phase of the product life cycle. The number one goal of this project was to establish an organization that has, as one of its purposes, the providing of services responsive to the needs of independent inventors. The number two goal was to demonstrate the value of providing marketing and manufacturing counsel at an early stage in the product development process. The first study goal was met by providing the materials and information necessary to establish an evaluation team and an organization to handle such evaluations. The second study goal was met by demonstrating the impact of early market analysis and manufacturing considerations on product design and therefore on the description of the invention for four different inventions. These inventions were selected at various stages of development. Regardless of stage of development, the marketing and manufacturing reviews resulted in significant changes in design and/or market positioning.

Developing an inventor support service which performs early stage market and manufacturing evaluations. [Final Report

Energy Technology Data Exchange (ETDEWEB)

1991-10-01

American businesses are learning the difficult high cost lesson of ignoring production and market factors (producibility, unit product cost (UPC), marketability, etc) during the engineering design phase of product development. Studies have shown that the Japanese spend three times as long as Americans in the design feasibility and decision process of new product introductions and one third the amount of time in the implementation of those products. There is a 20 to 1 cost benefit on effort applied in the design phase versus the production phase of the product life cycle. The number one goal of this project was to establish an organization that has, as one of its purposes, the providing of services responsive to the needs of independent inventors. The number two goal was to demonstrate the value of providing marketing and manufacturing counsel at an early stage in the product development process. The first study goal was met by providing the materials and information necessary to establish an evaluation team and an organization to handle such evaluations. The second study goal was met by demonstrating the impact of early market analysis and manufacturing considerations on product design and therefore on the description of the invention for four different inventions. These inventions were selected at various stages of development. Regardless of stage of development, the marketing and manufacturing reviews resulted in significant changes in design and/or market positioning.

Nondestructive phenotyping of lettuce plants in early stages of development with optical sensors

Science.gov (United States)

Rapid development of plants is important for the production of ‘baby-leaf’ lettuce that is harvested when plants reach the four- to eight-leaf stage of growth. However, environmental factors, such as high or low temperature, or elevated concentrations of salt, inhibit lettuce growth. Therefore, nond...

The problems of plant control on modern stage of development of the nuclear industry

Directory of Open Access Journals (Sweden)

Gusev S. S.

2017-04-01

Full Text Available the article describes the successful development of nuclear industry at the present stage of its development, the problems of control of nuclear power plants, their classes and the choices of modern science in the field of design of fast neutron reactors as one of the promising directions of development of atomic energy.

Developing a Guideline for Reporting and Evaluating Grounded Theory Research Studies (GUREGT)

DEFF Research Database (Denmark)

Berthelsen, Connie Bøttcher; Grimshaw-Aagaard, Søsserr Lone Smilla; Hansen, Carrinna

2018-01-01

theory research studies. The study was conducted in three phases. Phase 1: A structured literature review in PubMed, CINAHL, Cochrane Libraries, PsycInfo and SCOPUS to identify recommendations for reporting and evaluating grounded theory. Phase 2: A selective review of the methodological grounded theory...

Differences in adjustment by child developmental stage among caregivers of children with disorders of sex development

Science.gov (United States)

2011-01-01

Background The current study sought to compare levels of overprotection and parenting stress reported by caregivers of children with disorders of sex development at four different developmental stages. Methods Caregivers (N = 59) of children with disorders of sex development were recruited from specialty clinics and were asked to complete the Parent Protection Scale and Parenting Stress Index/Short Form as measures of overprotective behaviors and parenting stress, respectively. Results Analyses of covariance (ANCOVAs) were conducted to examine differences between caregiver report of overprotection and parenting stress. Results revealed that caregivers of infants and toddlers exhibited more overprotective behaviors than caregivers of children in the other age groups. Further, caregivers of adolescents experienced significantly more parenting stress than caregivers of school-age children, and this effect was driven by personal distress and problematic parent-child interactions, rather than having a difficult child. Conclusions These results suggest that caregivers of children with disorders of sex development may have different psychosocial needs based upon their child's developmental stage and based upon the disorder-related challenges that are most salient at that developmental stage. PMID:22074416

Design, construction, operation, shutdown and surveillance of repositories for solid radioactive wastes in shallow ground

International Nuclear Information System (INIS)

1984-01-01

This report is a part of the IAEA publications under its Programme on Underground Disposal of Radioactive Wastes and is addressed to administrative and technical authorities and specialists who consider the shallow-ground disposal of low- and intermediate-level solid radioactive wastes of short half-lives. The report emphasizes the technological aspects, however it briefly discusses the safety philosophy and regulatory considerations too. The design, construction, operation, shutdown and surveillance of the repositories in shallow ground are considered in some detail, paying special attention to their interrelated aspects. In particular, a review is given of the following aspects: main design and construction considerations in relation to the natural features of the site; design and construction aspects during the repository development process; activities related to operational and post-operational stages of the repository; major steps in repository operation and essential activities in shutdown and operational and post-operational surveillance

Development of suitability maps for ground-coupled heat pump systems using groundwater and heat transport models

Energy Technology Data Exchange (ETDEWEB)

Fujii, Hikari; Itoi, Ryuichi [Department of Earth Resources Engineering, Faculty of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395 (Japan); Inatomi, Tadasuke [YBM Co. Ltd., Kishiyama 589-10 Kitahata, Karatsu 847-1211 (Japan); Uchida, Youhei [Geological Survey of Japan, AIST Tsukuba Central 7, Tsukuba 305-8567 (Japan)

2007-10-15

The thermophysical properties of subsurface materials (soils, sediments and rocks) and groundwater flow strongly affect the heat exchange rates of ground heat exchangers (GHEs). These rates can be maximized and the installation costs of the ground-coupled heat pump (GCHP) systems reduced by developing suitability maps based on local geological and hydrological information. Such maps were generated for the Chikushi Plain (western Japan) using field-survey data and a numerical modeling study. First, a field-wide groundwater model was developed for the area and the results matched against measured groundwater levels and vertical temperature profiles. Single GHE models were then constructed to simulate the heat exchange performance at different locations in the plain. Finally, suitability maps for GCHP systems were prepared using the results from the single GHE models. Variations in the heat exchange rates of over 40% revealed by the map were ascribed to differences in the GHE locations, confirming how important it is to use appropriate thermophysical data when designing GCHP systems. (author)

Navigating the grounded theory terrain. Part 2.

Science.gov (United States)

Hunter, Andrew; Murphy, Kathy; Grealish, Annmarie; Casey, Dympna; Keady, John

2011-01-01

In this paper, the choice of classic grounded theory will be discussed and justified in the context of the first author's PhD research. The methodological discussion takes place within the context of PhD research entitled: Development of a stakeholder-led framework for a structured education programme that will prepare nurses and healthcare assistants to deliver a psychosocial intervention for people with dementia. There is a lack of research and limited understanding of the effect of psychosocial interventions on people with dementia. The first author thought classic grounded theory a suitable research methodology to investigate as it is held to be ideal for areas of research where there is little understanding of the social processes at work. The literature relating to the practical application of classic grounded theory is illustrated using examples relating to four key grounded theory components: Theory development: using constant comparison and memoing, Methodological rigour, Emergence of a core category, Inclusion of self and engagement with participants. Following discussion of the choice and application of classic grounded theory, this paper explores the need for researchers to visit and understand the various grounded theory options. This paper argues that researchers new to grounded theory must be familiar with and understand the various options. The researchers will then be able to apply the methodologies they choose consistently and critically. Doing so will allow them to develop theory rigorously and they will ultimately be able to better defend their final methodological destinations.

Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods, Stage 16

Energy Technology Data Exchange (ETDEWEB)

Pazsit, Imre; Dykin, Victor; Jonsson, Anders; Demaziere, Christophe (Chalmers Univ. of Technology, Dept. of Nuclear Engineering, Goeteborg (Sweden))

2010-12-15

This report gives an account of the work performed by the Dept. of Nuclear Engineering, Chalmers Univ. of Technology, in the frame of a research contract with the Swedish Radiation Safety Authority (SSM), contract No. SSM 2009/2093. The present report is based on work performed by Imre Pazsit, Victor Dykin, Anders Jonsson and Christophe Demaziere, with Imre Pazsit being the project leader. This report describes the results obtained during Stage 16 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. The long-term goals are elaborated in more detail in e.g. the Final Reports of Stage 1 and 2 (SKI Report 95:14 and 96:50, Pazsit et al. 1995, 1996). Results up to Stage 15 were reported in (Pazsit et al. 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2003a, 2003b; Demaziere et al, 2004; Sunde et al, 2006; Pazsit et al. 2008, 2009). A brief proposal for the continuation of this program in Stage 17 is also given at the end of the report. The program executed in Stage 16 consists of four parts as follows: - An overview of the present status of experience with BWR stability; - An investigation of the significance of the properties of the noise source for BWR instability; - Study of the dynamics of molten salt systems: construction of the adjoint and calculating the space dependent noise induced by propagating perturbations in the fuel; - A specific study of some novel methods of analysis of non-linear and non-stationary processes

Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods, Stage 16

International Nuclear Information System (INIS)

Pazsit, Imre; Dykin, Victor; Jonsson, Anders; Demaziere, Christophe

2010-12-01

This report gives an account of the work performed by the Dept. of Nuclear Engineering, Chalmers Univ. of Technology, in the frame of a research contract with the Swedish Radiation Safety Authority (SSM), contract No. SSM 2009/2093. The present report is based on work performed by Imre Pazsit, Victor Dykin, Anders Jonsson and Christophe Demaziere, with Imre Pazsit being the project leader. This report describes the results obtained during Stage 16 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. The long-term goals are elaborated in more detail in e.g. the Final Reports of Stage 1 and 2 (SKI Report 95:14 and 96:50, Pazsit et al. 1995, 1996). Results up to Stage 15 were reported in (Pazsit et al. 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2003a, 2003b; Demaziere et al, 2004; Sunde et al, 2006; Pazsit et al. 2008, 2009). A brief proposal for the continuation of this program in Stage 17 is also given at the end of the report. The program executed in Stage 16 consists of four parts as follows: - An overview of the present status of experience with BWR stability; - An investigation of the significance of the properties of the noise source for BWR instability; - Study of the dynamics of molten salt systems: construction of the adjoint and calculating the space dependent noise induced by propagating perturbations in the fuel; - A specific study of some novel methods of analysis of non-linear and non-stationary processes

Medical Informatics Specialty in the Developed English-Speaking Countries: The Terminology Comparative Analysis

Science.gov (United States)

Kobryn, Nadia

2015-01-01

The article studies the development process of medical informatics specialty terminology as the ground for further research into foreign countries' experience, including the Canadian one, of specialists' professional training in the field of MI. The study determines the origin and chief stages of the formation and development of the medical…

Doing the Things We Do: A Grounded Theory of Academic Procrastination

Science.gov (United States)

Schraw, Gregory; Wadkins, Theresa; Olafson, Lori

2007-01-01

The authors conducted a grounded theory study of academic procrastination to explore adaptive and maladaptive aspects of procrastination and to help guide future empirical research. They discuss previous research on the definition and dimensionality of procrastination and describe the study in which interview data were collected in 4 stages,…

Development and testing of a de novo clinical staging system for podoconiosis (endemic non-filarial elephantiasis).

Science.gov (United States)

Tekola, Fasil; Ayele, Zewdu; Mariam, Dereje Haile; Fuller, Claire; Davey, Gail

2008-10-01

To develop and test a robust clinical staging system for podoconiosis, a geochemical disease in individuals exposed to red clay soil. We adapted the Dreyer system for staging filarial lymphoedema and tested it in four re-iterative field tests conducted in an area of high-podoconiosis prevalence in Southern Ethiopia. The system has five stages according to proximal spread of disease and presence of dermal nodules, ridges and bands. We measured the 1-week repeatability and the inter-observer agreement of the final staging system. The five-stage system is readily understood by community workers with little health training. Kappa for 1-week repeatability was 0.88 (95% CI 0.80-0.96), for agreement between health professionals was 0.71 (95% CI 0.60-0.82), while that between health professionals and community podoconiosis agents without formal health training averaged 0.64 (95% CI 0.52-0.78). This simple staging system with good inter-observer agreement and repeatability can assist in the management and further study of podoconiosis.

Application of Artificial Thunderstorm Cells for the Investigation of Lightning Initiation Problems between a Thundercloud and the Ground

Science.gov (United States)

Temnikov, A. G.; Chernensky, L. L.; Orlov, A. V.; Lysov, N. Y.; Zhuravkova, D. S.; Belova, O. S.; Gerastenok, T. K.

2017-12-01

The results of the experimental application of artificial thunderstorm cells of negative and positive polarities for the investigation of the lightning initiation problems between the thundercloud and the ground using model hydrometeor arrays are presented. Possible options of the initiation and development of a discharge between the charged cloud and the ground in the presence of model hydrometeors are established. It is experimentally shown that groups of large hydrometeors of various shapes significantly increase the probability of channel discharge initiation between the artificial thunderstorm cell and the ground, especially in the case of positive polarity of the cloud. The authors assume that large hail arrays in the thundercloud can initiate the preliminary breakdown stage in the lower part of the thundercloud or initiate and stimulate the propagation of positive lightning from its upper part. A significant effect of the shape of model hydrometeors and the way they are grouped on the processes of initiation and stimulation of the channel discharge propagation in the artificial thunderstorm cell of negative or positive polarity-ground gap is experimentally established. It is found that, in the case of negative polarity of a charged cloud, the group of conductive cylindrical hydrometeors connected by a dielectric string more effectively initiates the channel discharge between the artificial thunderstorm cell and the ground. In the case of positive polarity of the artificial thunderstorm cell, the best effect of the channel discharge initiation is achieved for model hydrometeors grouped together by the dielectric tape. The obtained results can be used in the development of the method for the directed artificial lightning initiation between the thundercloud and the ground.

Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region.

Science.gov (United States)

Orjuela-Sanchez, Pamela; Villa, Zaira Hellen; Moreno, Marta; Tong-Rios, Carlos; Meister, Stephan; LaMonte, Gregory M; Campo, Brice; Vinetz, Joseph M; Winzeler, Elizabeth A

2018-04-13

To develop new drugs and vaccines for malaria elimination, it will be necessary to discover biological interventions, including small molecules that act against Plasmodium vivax exoerythrocytic forms. However, a robust in vitro culture system for P. vivax is still lacking. Thus, to study exoerythrocytic forms, researchers must have simultaneous access to fresh, temperature-controlled patient blood samples, as well as an anopheline mosquito colony. In addition, researchers must rely on native mosquito species to avoid introducing a potentially dangerous invasive species into a malaria-endemic region. Here, we report an in vitro culture system carried out on site in a malaria-endemic region for liver stage parasites of P. vivax sporozoites obtained from An. darlingi, the main malaria vector in the Americas. P. vivax sporozoites were obtained by dissection of salivary glands from infected An. darlingi mosquitoes and purified by Accudenz density gradient centrifugation. HC04 liver cells were exposed to P. vivax sporozoites and cultured up to 9 days. To overcome low P. vivax patient parasitemias, potentially lower mosquito vectorial capacity, and humid, nonsterile environmental conditions, a new antibiotic cocktail was included in tissue culture to prevent contamination. Culturing conditions supported exoerythrocytic (EEF) P. vivax liver stage growth up to 9 days and allowed for maturation into intrahepatocyte merosomes. Some of the identified small forms were resistant to atovaquone (1 μM) but sensitive to the phosphatidylinositol 4-kinase inhibitor, KDU691 (1 μM). This study reports a field-accessible EEF production process for drug discovery in a malaria-endemic site in which viable P. vivax sporozoites are used for drug studies using hepatocyte infection. Our data demonstrate that the development of meaningful, field-based resources for P. vivax liver stage drug screening and liver stage human malaria experimentation in the Amazon region is feasible.

Development of a low-temperature two-stage fluidized bed incinerator for controlling heavy-metal emission in flue gases

International Nuclear Information System (INIS)

Peng, Tzu-Huan; Lin, Chiou-Liang; Wey, Ming-Yen

2014-01-01

This study develops a low-temperature two-stage fluidized bed system for treating municipal solid waste. This new system can decrease the emission of heavy metals, has low construction costs, and can save energy owing to its lower operating temperature. To confirm the treatment efficiency of this system, the combustion efficiency and heavy-metal emission were determined. An artificial waste containing heavy metals (chromium, lead, and cadmium) was used in this study. The tested parameters included first-stage temperature and system gas velocity. Results obtained using a thermogravimetric analyzer with a differential scanning calorimeter indicated that the first-stage temperature should be controlled to at least 400 °C. Although, a large amount of carbon monoxide was emitted after the first stage, it was efficiently consumed in the second. Loss of the ignition values of ash residues were between 0.005% and 0.166%, and they exhibited a negative correlation with temperature and gas velocity. Furthermore, the emission concentration of heavy metals in the two-stage system was lower than that of the traditional one-stage fluidized bed system. The heavy-metal emissions can be decreased by between 16% and 82% using the low-temperature operating process, silica sand adsorption, and the filtration of the secondary stage. -- Graphical abstract: Heavy-metal emission concentrations in flue gases under different temperatures and gas velocities (dashed line: average of the heavy-metal emission in flue gases in the one-stage fluidized-bed incinerator). Highlights: • Low temperature two-stage system is developed to control heavy metal. • The different first-stage temperatures affect the combustion efficiency. • Surplus CO was destroyed efficiently by the secondary fluidized bed combustor. • Metal emission in two-stage system is lower than in the traditional system. • Temperature, bed adsorption, and filtration are the main control mechanisms

Ground Source Integrated Heat Pump (GS-IHP) Development

Energy Technology Data Exchange (ETDEWEB)

Baxter, V. D. [ORNL; Rice, K. [ORNL; Murphy, R. [ORNL; Munk, J. [ORNL; Ally, Moonis [ORNL; Shen, Bo [ORNL; Craddick, William [ORNL; Hearn, Shawn A. [ClimateMaster, Inc.

2013-05-24

Between October 2008 and May 2013 ORNL and ClimateMaster, Inc. (CM) engaged in a Cooperative Research and Development Agreement (CRADA) to develop a groundsource integrated heat pump (GS-IHP) system for the US residential market. A initial prototype was designed and fabricated, lab-tested, and modeled in TRNSYS (SOLAR Energy Laboratory, et al, 2010) to predict annual performance relative to 1) a baseline suite of equipment meeting minimum efficiency standards in effect in 2006 (combination of air-source heat pump (ASHP) and resistance water heater) and 2) a state-of-the-art (SOA) two-capacity ground-source heat pump with desuperheater water heater (WH) option (GSHPwDS). Predicted total annual energy savings, while providing space conditioning and water heating for a 2600 ft{sup 2} (242 m{sup 2}) house at 5 U.S. locations, ranged from 52 to 59%, averaging 55%, relative to the minimum efficiency suite. Predicted energy use for water heating was reduced 68 to 78% relative to resistance WH. Predicted total annual savings for the GSHPwDS relative to the same baseline averaged 22.6% with water heating energy use reduced by 10 to 30% from desuperheater contributions. The 1st generation (or alpha) prototype design for the GS-IHP was finalized in 2010 and field test samples were fabricated for testing by CM and by ORNL. Two of the alpha units were installed in 3700 ft{sup 2} (345 m{sup 2}) houses at the ZEBRAlliance site in Oak Ridge and field tested during 2011. Based on the steady-state performance demonstrated by the GS-IHPs it was projected that it would achieve >52% energy savings relative to the minimum efficiency suite at this specific site. A number of operational issues with the alpha units were identified indicating design changes needed to the system before market introduction could be accomplished. These were communicated to CM throughout the field test period. Based on the alpha unit test results and the diagnostic information coming from the field test

First status report on regional ground-water flow modeling for Vacherie Dome, Louisiana

International Nuclear Information System (INIS)

1986-07-01

Regional ground-water flow within the principal geohydrologic units in the vicinity of Vacherie Dome, Louisiana is evaluated by developing a conceptual model of the flow regime within these units and testing the model using a three-dimensional, finite-difference flow code (SWENT). Semiquantitative sensitivity analyses (a limited parametric study) are conducted to define the system responses to changes in the conceptual model, particularly in regard to the geohydrologic properties. All steps leading to the final results and conclusions are incorporated in this report. The available data utilized in this study are summarized. The conceptual model is defined in terms of the areal and vertical averaging of lithologic units, aquifer properties, and hydrologic boundary conditions. The simulated ground-water flow fields are described with potentiometric surfaces, areas of upward and downward flow across aquitards, tables summarizing the horizontal and vertical volumetric flows through the principal units, ground-water travel times and paths, and Darcy velocities within specified finite-difference blocks. The reported work is the first stage of an ongoing evaluation of Vacherie Dome as a potential repository for high-level radioactive wastes. The results and conclusions should thus be considered preliminary and subject to modification with the collection of additional data. However, the report does provide a useful basis for describing the sensitivity of the conceptualization of ground-water flow to parameterization and, to a lesser extent, the uncertainties in the present conceptualization. 34 refs., 57 figs., 19 tabs

Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development.

Science.gov (United States)

Das, Sujaan; Lemgruber, Leandro; Tay, Chwen L; Baum, Jake; Meissner, Markus

2017-08-15

The phylum Apicomplexa includes intracellular parasites causing immense global disease burden, the deadliest of them being the human malaria parasite Plasmodium falciparum, which invades and replicates within erythrocytes. The cytoskeletal protein actin is well conserved within apicomplexans but divergent from mammalian actins, and was primarily reported to function during host cell invasion. However, novel invasion mechanisms have been described for several apicomplexans, and specific functions of the acto-myosin system are being reinvestigated. Of the two actin genes in P. falciparum, actin-1 (pfact1) is ubiquitously expressed in all life-cycle stages and is thought to be required for erythrocyte invasion, although its functions during parasite development are unknown, and definitive in vivo characterisation during invasion is lacking. Here we have used a conditional Cre-lox system to investigate the functions of PfACT1 during P. falciparum blood-stage development and host cell invasion. We demonstrate that PfACT1 is crucially required for segregation of the plastid-like organelle, the apicoplast, and for efficient daughter cell separation during the final stages of cytokinesis. Surprisingly, we observe that egress from the host cell is not an actin-dependent process. Finally, we show that parasites lacking PfACT1 are capable of microneme secretion, attachment and formation of a junction with the erythrocyte, but are incapable of host cell invasion. This study provides important mechanistic insights into the definitive essential functions of PfACT1 in P. falciparum, which are not only of biological interest, but owing to functional divergence from mammalian actins, could also form the basis for the development of novel therapeutics against apicomplexans.

Development and performance validation of a cryogenic linear stage for SPICA-SAFARI verification

Science.gov (United States)

Ferrari, Lorenza; Smit, H. P.; Eggens, M.; Keizer, G.; de Jonge, A. W.; Detrain, A.; de Jonge, C.; Laauwen, W. M.; Dieleman, P.

2014-07-01

In the context of the SAFARI instrument (SpicA FAR-infrared Instrument) SRON is developing a test environment to verify the SAFARI performance. The characterization of the detector focal plane will be performed with a backilluminated pinhole over a reimaged SAFARI focal plane by an XYZ scanning mechanism that consists of three linear stages stacked together. In order to reduce background radiation that can couple into the high sensitivity cryogenic detectors (goal NEP of 2•10-19 W/√Hz and saturation power of few femtoWatts) the scanner is mounted inside the cryostat in the 4K environment. The required readout accuracy is 3 μm and reproducibility of 1 μm along the total travel of 32 mm. The stage will be operated in "on the fly" mode to prevent vibrations of the scanner mechanism and will move with a constant speed varying from 60 μm/s to 400 μm/s. In order to meet the requirements of large stroke, low dissipation (low friction) and high accuracy a DC motor plus spindle stage solution has been chosen. In this paper we will present the stage design and stage characterization, describing also the measurements setup. The room temperature performance has been measured with a 3D measuring machine cross calibrated with a laser interferometer and a 2-axis tilt sensor. The low temperature verification has been performed in a wet 4K cryostat using a laser interferometer for measuring the linear displacements and a theodolite for measuring the angular displacements. The angular displacements can be calibrated with a precision of 4 arcsec and the position could be determined with high accuracy. The presence of friction caused higher values of torque than predicted and consequently higher dissipation. The thermal model of the stage has also been verified at 4K.

A 3D reconstruction of pancreas development in the human embryos during embryonic period (Carnegie stages 15-23).

Science.gov (United States)

Radi, M; Gaubert, J; Cristol-Gaubert, R; Baecker, V; Travo, P; Prudhomme, M; Godlewski, G; Prat-Pradal, D

2010-01-01

The goal in this paper was to rebuild a three dimensional (3D) reconstruction of the dorsal and ventral pancreatic buds, in the human embryos, at Carnegie stages 15-23. The early development of the pancreas is studied by tissue observation and reconstruction by a computer-assisted method, using a light micrograph images from consecutive serial sagittal sections (diameter 7 microm) of ten human embryos ranging from Carnegie stages 15-23, CRL 7-27 mm, fixed, dehydrated and embedded in paraffin, were stained alternately with haematoxylin-eosin or Heindenhain'Azan. The images were digitalized by Canon Camera 350 EOS D. The serial views were aligned automatically by software, manual alignment was performed, the data were analysed following segmentation and threshold. The two buds were clearly identified at stage 15. In stage 16, both pancreatic buds were in final position, and begin to merge in stage 17. From stage 18 to the stage 23, surrounding connective tissue differentiated. In the stage 23, the morphology of the pancreas was definitive. The superior portion of the anterior face of the pancreas's head was arising from the dorsal bud. The rest of the head including the uncinate process emanated from the ventral bud. The 3D computer-assisted reconstruction of the human pancreas visualized the relationships between the two pancreatic buds. This explains the disposition and the modality of the components fusion. This embryologic development permits a better understanding of congenital abnormalities.

A Grounded Theory Approach to Physical Activity and Advanced Cancer

Directory of Open Access Journals (Sweden)

Sonya S. Lowe

2015-11-01

Full Text Available Background: Physical activity has demonstrated benefits in cancer-related fatigue and physical functioning in early-stage cancer patients, however the role of physical activity at the end stage of cancer has not been established. To challenge positivist–empiricist assumptions, I am seeking to develop a new theoretical framework that is grounded in the advanced cancer patient’s experience of activity. Aim: To gain an in-depth understanding of the experience of activity and quality of life in advanced cancer patients. Objectives: (1 To explore the meaning of activity for advanced cancer patients in the context of their day-to-day life, (2 to elicit advanced cancer patients’ perceptions of activity with respect to their quality of life, and (3 to elicit advanced cancer patients’ views of barriers and facilitators to activity in the context of their day-to-day life. Study Design: A two-phase, cross-sectional, qualitative study will be conducted through the postpositivist lens of subtle realism and informed by the principles of grounded theory methods. Study Methods: Advanced cancer patients will be recruited through the outpatient department of a tertiary cancer center. For Phase one, participants will wear an activPAL™ activity monitor and fill out a daily record sheet for seven days duration. For Phase two, the activity monitor output and daily record sheets will be used as qualitative probes for face-to-face, semistructured interviews. Concurrent coding, constant comparative analysis, and theoretical sampling will continue with the aim of achieving as close as possible to theoretical saturation. Ethics and Discussion: Ethical and scientific approval will be obtained by all local institutional review boards prior to study commencement. The findings will generate new mid-level theory about the experience of activity and quality of life in advanced cancer patients and aid in the development of a new theoretical framework for designing

Water resources data for Florida, water year 1992. Volume 1B. Northeast Florida ground water. Water-data report (Annual) October 1, 1991-September 30, 1992

International Nuclear Information System (INIS)

1993-01-01

Water resources data for the 1992 for northeast Florida include continuous or daily discharge for 140 streams, periodic discharge for 10 streams, miscellaneous discharge for 14 streams, continuous or daily stage for 32 streams, continuous or daily tide stage for 3 sites, periodic stage for 23 streams, peak discharge for 3 streams, and peak stage for 11 streams; continuous or daily elevations for 36 lakes, periodic elevations for 47 lakes; continuous ground-water levels for 75 wells, periodic ground-water levels for 123 wells, and miscellaneous water-level measurements for 864 wells; and quality-of-water data for 38 surface-water sites and 66 wells

Using Simulated Ground Motions to Constrain Near-Source Ground Motion Prediction Equations in Areas Experiencing Induced Seismicity

Science.gov (United States)

Bydlon, S. A.; Dunham, E. M.

2016-12-01

Recent increases in seismic activity in historically quiescent areas such as Oklahoma, Texas, and Arkansas, including large, potentially induced events such as the 2011 Mw 5.6 Prague, OK, earthquake, have spurred the need for investigation into expected ground motions associated with these seismic sources. The neoteric nature of this seismicity increase corresponds to a scarcity of ground motion recordings within 50 km of earthquakes Mw 3.0 and greater, with increasing scarcity at larger magnitudes. Gathering additional near-source ground motion data will help better constraints on regional ground motion prediction equations (GMPEs) and will happen over time, but this leaves open the possibility of damaging earthquakes occurring before potential ground shaking and seismic hazard in these areas are properly understood. To aid the effort of constraining near-source GMPEs associated with induced seismicity, we integrate synthetic ground motion data from simulated earthquakes into the process. Using the dynamic rupture and seismic wave propagation code waveqlab3d, we perform verification and validation exercises intended to establish confidence in simulated ground motions for use in constraining GMPEs. We verify the accuracy of our ground motion simulator by performing the PEER/SCEC layer-over-halfspace comparison problem LOH.1 Validation exercises to ensure that we are synthesizing realistic ground motion data include comparisons to recorded ground motions for specific earthquakes in target areas of Oklahoma between Mw 3.0 and 4.0. Using a 3D velocity structure that includes a 1D structure with additional small-scale heterogeneity, the properties of which are based on well-log data from Oklahoma, we perform ground motion simulations of small (Mw 3.0 - 4.0) earthquakes using point moment tensor sources. We use the resulting synthetic ground motion data to develop GMPEs for small earthquakes in Oklahoma. Preliminary results indicate that ground motions can be amplified

An embryonic staging table for in ovo development of Eublepharis macularius, the leopard gecko.

Science.gov (United States)

Wise, Patrick A D; Vickaryous, Matthew K; Russell, Anthony P

2009-08-01

Squamates constitute a major vertebrate radiation, representing almost one-third of all known amniotes. Although speciose and morphologically diverse, they remain poorly represented in developmental studies. Here, we present an embryonic staging table of in ovo development for the basal gekkotan Eublepharis macularius (the leopard gecko) and advocate this species as a laboratory-appropriate developmental model. E. macularius, is a hardy and tractable species of relatively large body size (with concomitantly relatively large eggs and embryos), that is widely available and easy to maintain and propagate. Additionally, E. macularius displays a body plan appropriate to the study of the plesiomorphic quadrupedal condition of early pentadactylous terrestrial amniotes. Although not unexpected, it is worth noting that the morphological events characterizing limb development in E. macularius are comparable with those described for the avian Gallus gallus. Therefore, E. macularius holds great promise as a model for developmental studies focusing on pentadactyly and the formation of digits. Furthermore, it is also attractive as a developmental model because it demonstrates temperature-dependent sex determination. The staging table presented herein is based on an all-female series and represents the entire 52 day in ovo period. Overall, embryogenesis of E. macularius is similar to that of other squamates in terms of developmental stage attained at the time of oviposition, patterns of limb and pharyngeal arch development, and features of the appearance of scalation and pigmentation, indicative of a conserved developmental program. (c) 2009 Wiley-Liss, Inc.

Multi-stage subunit vaccine development against Mycobacterium paratuberculosis and Johne’s disease in ruminants

DEFF Research Database (Denmark)

Jungersen, Gregers

paratuberculosis provide only partial protection and interfere with diagnostic tests for JD and surveillance for bovine TB. In contrast, recombinant subunit vaccines can be designed to be used without compromising control of bTB and Map. Taking advantage of data from mouse TB studies, and early Map vaccination...... in macrophages. The disease progression is very slow with neonatal animals being the most susceptible to infection, but without development of detectable IFN-γ responses for months after infection and rarely with clinical disease before the second or third year of life. Available whole cell vaccines against......- and field-studies we developed a vaccine with a single recombinant fusion protein comprising four acute-stage antigens (Ags) and one latent-stage Ag formulated in adjuvant (FET-vaccine). In post-exposure vaccination of calves and goats with necropsy 8-12 months post inoculation, we determined...

Integrating Environmental Decisions into the Product Development Process: Part 2 - The Later Stages

DEFF Research Database (Denmark)

Poole, S.; Simon, M; Sweatman, A.

1999-01-01

, Central Europe, and the USA are carrying out ecodesign. The survey also investigated the successes and failures that compnies have experienced and the lessons learned along the way. Part 1 of this two-part paper focuses on the early stages of the product development process. It shows how products can...

The illusion of parental celibacy. A necessary stage in adolescent development.

Science.gov (United States)

Shopper, Moisy

2002-01-01

The paper begins by reviewing Freud's case history of Dora and emphasizing her involvement in and overstimulation by her parents' sexual behavior. This markedly interfered with her ability to desexualize her relationship with them. As a result she was unable to develop the illusion of parental celibacy, which I postulate is an important and necessary defensive stage in normal adolescence. This illusion facilitates the desexualization of the adolescent's relationship to the parents and so contributes to separation from them and the seeking of non-incestuous sexual outlets. The disruption of this illusion of parental celibacy by parental sex education, or by the complications of parental divorce may contribute significantly to the development of adolescent psychopathology. Clinical vignettes are presented.

Advanced Testing Method for Ground Thermal Conductivity

Energy Technology Data Exchange (ETDEWEB)

Liu, Xiaobing [ORNL; Clemenzi, Rick [Geothermal Design Center Inc.; Liu, Su [University of Tennessee (UT)

2017-04-01

A new method is developed that can quickly and more accurately determine the effective ground thermal conductivity (GTC) based on thermal response test (TRT) results. Ground thermal conductivity is an important parameter for sizing ground heat exchangers (GHEXs) used by geothermal heat pump systems. The conventional GTC test method usually requires a TRT for 48 hours with a very stable electric power supply throughout the entire test. In contrast, the new method reduces the required test time by 40%–60% or more, and it can determine GTC even with an unstable or intermittent power supply. Consequently, it can significantly reduce the cost of GTC testing and increase its use, which will enable optimal design of geothermal heat pump systems. Further, this new method provides more information about the thermal properties of the GHEX and the ground than previous techniques. It can verify the installation quality of GHEXs and has the potential, if developed, to characterize the heterogeneous thermal properties of the ground formation surrounding the GHEXs.

Commissioning of the Ground Test Accelerator Intertank Matching Section

International Nuclear Information System (INIS)

Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Cole, R.; Connolly, R.; Gilpatrick, J.D.; Ingalls, W.B.; Kersteins, D.; Little, C.; Lohsen, R.A.; Lysenko, W.P.; Mottershead, C.T.; Power, J.; Rusthoi, D.P.; Sandoval, D.P.; Stevens, R.R.; Vaughn, G.; Wadlinger, E.A.; Weiss, R.; Yuan, V.

1992-01-01

The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H - beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on-line. The commissioning stages are the 35 keV H - injector, the 2.5 MeV Radio Frequency Quadrupole (RFQ), the Intertank Matching Section (IMS), the 3.2 MeV first 2βγ Drift Tube Linac (DTL-1) module, the 8.7 MeV 2βγ DTL (modules 1--5), and the 24 MeV GTA; all 10 DTL modules. Commissioning results from the IMS beam experiments will be presented

Physiological quality and gene expression related to heat-resistant proteins at different stages of development of maize seeds.

Science.gov (United States)

Andrade, T; Von Pinho, E V R; Von Pinho, R G; Oliveira, G E; Andrade, V; Fernandes, J S

2013-09-13

We quantified and characterized the expression of heat-resistant proteins during seed development of maize lines with distinct levels of tolerance to high drying temperature. A corn field was planted for multiplication of seeds of different lines, two tolerant and two non-tolerant to high drying temperatures. Harvest of the seeds was carried out at various stages of development and they were then subjected to tests of moisture content, germination, first count of germination, accelerated aging, and cold test. The seeds were stored in a freezer for later analysis of expression of heat-resistant proteins by means of real-time PCR, electrophoresis, and spectrophotometry. We observed that heat-resistant proteins are expressed in a differential manner in seeds from different lines and at different stages of development. The expression of heat-resistant proteins was earlier in lines tolerant to high drying temperatures. Greater germination and vigor values was found for seeds collected at the last stage of development.

XML Flight/Ground Data Dictionary Management

Science.gov (United States)

Wright, Jesse; Wiklow, Colette

2007-01-01

A computer program generates Extensible Markup Language (XML) files that effect coupling between the command- and telemetry-handling software running aboard a spacecraft and the corresponding software running in ground support systems. The XML files are produced by use of information from the flight software and from flight-system engineering. The XML files are converted to legacy ground-system data formats for command and telemetry, transformed into Web-based and printed documentation, and used in developing new ground-system data-handling software. Previously, the information about telemetry and command was scattered in various paper documents that were not synchronized. The process of searching and reading the documents was time-consuming and introduced errors. In contrast, the XML files contain all of the information in one place. XML structures can evolve in such a manner as to enable the addition, to the XML files, of the metadata necessary to track the changes and the associated documentation. The use of this software has reduced the extent of manual operations in developing a ground data system, thereby saving considerable time and removing errors that previously arose in the translation and transcription of software information from the flight to the ground system.

Communication grounding facility

International Nuclear Information System (INIS)

Lee, Gye Seong

1998-06-01

It is about communication grounding facility, which is made up twelve chapters. It includes general grounding with purpose, materials thermal insulating material, construction of grounding, super strength grounding method, grounding facility with grounding way and building of insulating, switched grounding with No. 1A and LCR, grounding facility of transmission line, wireless facility grounding, grounding facility in wireless base station, grounding of power facility, grounding low-tenton interior power wire, communication facility of railroad, install of arrester in apartment and house, install of arrester on introduction and earth conductivity and measurement with introduction and grounding resistance.

The role of community mental health nurses caring for people with schizophrenia in Taiwan: a substantive grounded theory.

Science.gov (United States)

Huang, Xuan-Yi; Yen, Wen-Jiuan; Liu, Shwu-Jiuan; Lin, Chouh-Jiuan

2008-03-01

The aim was to develop a practice theory that can be used to guide the direction of community nursing practice to help clients with schizophrenia and those who care for them. Substantive grounded theory was developed through use of grounded theory method of Strauss and Corbin. Two groups of participants in Taiwan were selected using theoretical sampling: one group consisted of community mental health nurses and the other group was clients with schizophrenia and those who cared for them. The number of participants in each group was determined by theoretical saturation. Semi-structured one-to-one in-depth interviews and unstructured non-participant observation were utilized for data collection. Data analysis involved three stages: open, axial and selective coding. During the process of coding and analysis, both inductive and deductive thinking were utilized and the constant comparative analysis process continued until data saturation occurred. To establish trustworthiness, the four criteria of credibility, transferability, dependability and confirmability were followed along with field trial, audit trial, member check and peer debriefing for reliability and validity. A substantive grounded theory, the role of community mental health nurses caring for people with schizophrenia in Taiwan, was developed through utilization of grounded theory method of Strauss and Corbin. In this paper, results and discussion focus on causal conditions, context, intervening conditions, consequences and phenomenon. The theory is the first to contribute knowledge about the field of mental health home visiting services in Taiwan to provide guidance for the delivery of quality care to assist people in the community with schizophrenia and their carers.

The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?

Energy Technology Data Exchange (ETDEWEB)

Tepper, Leonie A. [Sophia Children' s Hospital, Department of Pediatric Pulmonology, Erasmus MC, Rotterdam (Netherlands); Sophia Children' s Hospital, Department of Radiology, Erasmus MC, Rotterdam (Netherlands); Caudri, Daan [Sophia Children' s Hospital, Department of Pediatric Pulmonology, Erasmus MC, Rotterdam (Netherlands); Perez Rovira, Adria [Sophia Children' s Hospital, Department of Pediatric Pulmonology, Erasmus MC, Rotterdam (Netherlands); Erasmus MC, Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Rotterdam (Netherlands); Tiddens, Harm A.W.M. [Sophia Children' s Hospital, Department of Pediatric Pulmonology, Erasmus MC, Rotterdam (Netherlands); Sophia Children' s Hospital, Department of Radiology, Erasmus MC, Rotterdam (Netherlands); Sophia Children' s Hospital, Department of Pediatric Pulmonology and Radiology, Erasmus Medical Center, Rotterdam (Netherlands); Bruijne, Marleen de [Erasmus MC, Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Rotterdam (Netherlands); University of Copenhagen, Department of Computer Science, Copenhagen (Denmark)

2016-12-15

Bronchiectasis is an important component of cystic fibrosis (CF) lung disease but little is known about its development. We aimed to study the development of bronchiectasis and identify determinants for rapid progression of bronchiectasis on chest CT. Forty-three patients with CF with at least four consecutive biennial volumetric CTs were included. Areas with bronchiectasis on the most recent CT were marked as regions of interest (ROIs). These ROIs were generated on all preceding CTs using deformable image registration. Observers indicated whether: bronchiectasis, mucus plugging, airway wall thickening, atelectasis/consolidation or normal airways were present in the ROIs. We identified 362 ROIs on the most recent CT. In 187 (51.7 %) ROIs bronchiectasis was present on all preceding CTs, while 175 ROIs showed development of bronchiectasis. In 139/175 (79.4 %) no pre-stages of bronchiectasis were identified. In 36/175 (20.6 %) bronchiectatic airways the following pre-stages were identified: mucus plugging (17.7 %), airway wall thickening (1.7 %) or atelectasis/consolidation (1.1 %). Pancreatic insufficiency was more prevalent in the rapid progressors compared to the slow progressors (p = 0.05). Most bronchiectatic airways developed within 2 years without visible pre-stages, underlining the treacherous nature of CF lung disease. Mucus plugging was the most frequent pre-stage. (orig.)

The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?

International Nuclear Information System (INIS)

Tepper, Leonie A.; Caudri, Daan; Perez Rovira, Adria; Tiddens, Harm A.W.M.; Bruijne, Marleen de

2016-01-01

Bronchiectasis is an important component of cystic fibrosis (CF) lung disease but little is known about its development. We aimed to study the development of bronchiectasis and identify determinants for rapid progression of bronchiectasis on chest CT. Forty-three patients with CF with at least four consecutive biennial volumetric CTs were included. Areas with bronchiectasis on the most recent CT were marked as regions of interest (ROIs). These ROIs were generated on all preceding CTs using deformable image registration. Observers indicated whether: bronchiectasis, mucus plugging, airway wall thickening, atelectasis/consolidation or normal airways were present in the ROIs. We identified 362 ROIs on the most recent CT. In 187 (51.7 %) ROIs bronchiectasis was present on all preceding CTs, while 175 ROIs showed development of bronchiectasis. In 139/175 (79.4 %) no pre-stages of bronchiectasis were identified. In 36/175 (20.6 %) bronchiectatic airways the following pre-stages were identified: mucus plugging (17.7 %), airway wall thickening (1.7 %) or atelectasis/consolidation (1.1 %). Pancreatic insufficiency was more prevalent in the rapid progressors compared to the slow progressors (p = 0.05). Most bronchiectatic airways developed within 2 years without visible pre-stages, underlining the treacherous nature of CF lung disease. Mucus plugging was the most frequent pre-stage. (orig.)

Development Stages and Curriculum: A Japanese Perspective.

Science.gov (United States)

Abiko, Tadahiko

2002-01-01

Discusses contemporary psychologists' criticism of Jean Piaget's developmental theory; reviews research in brain science, psychology, history, and the experiences of teachers; proposes a new theory of developmental stages based on children's shifting interests; discuses implications of "shifting interest center theory" for school…

Multi-body simulation of a canine hind limb: model development, experimental validation and calculation of ground reaction forces

Directory of Open Access Journals (Sweden)

Wefstaedt Patrick

2009-11-01

Full Text Available Abstract Background Among other causes the long-term result of hip prostheses in dogs is determined by aseptic loosening. A prevention of prosthesis complications can be achieved by an optimization of the tribological system which finally results in improved implant duration. In this context a computerized model for the calculation of hip joint loadings during different motions would be of benefit. In a first step in the development of such an inverse dynamic multi-body simulation (MBS- model we here present the setup of a canine hind limb model applicable for the calculation of ground reaction forces. Methods The anatomical geometries of the MBS-model have been established using computer tomography- (CT- and magnetic resonance imaging- (MRI- data. The CT-data were collected from the pelvis, femora, tibiae and pads of a mixed-breed adult dog. Geometric information about 22 muscles of the pelvic extremity of 4 mixed-breed adult dogs was determined using MRI. Kinematic and kinetic data obtained by motion analysis of a clinically healthy dog during a gait cycle (1 m/s on an instrumented treadmill were used to drive the model in the multi-body simulation. Results and Discussion As a result the vertical ground reaction forces (z-direction calculated by the MBS-system show a maximum deviation of 1.75%BW for the left and 4.65%BW for the right hind limb from the treadmill measurements. The calculated peak ground reaction forces in z- and y-direction were found to be comparable to the treadmill measurements, whereas the curve characteristics of the forces in y-direction were not in complete alignment. Conclusion In conclusion, it could be demonstrated that the developed MBS-model is suitable for simulating ground reaction forces of dogs during walking. In forthcoming investigations the model will be developed further for the calculation of forces and moments acting on the hip joint during different movements, which can be of help in context with the in

METHODOLOGICAL GROUNDS ABOUT ALGORITHM OF DEVELOPMENT ORGANIZATIONAL ANALYSIS OF RAILWAYS OPERATION

Directory of Open Access Journals (Sweden)

H. D. Eitutis

2010-12-01

Full Text Available It was established that the initial stage of reorganization is to run diagnostics of the enterprise, under which a decision on development of an algorithm for structural transformations shall be made. Organizational and management analysis is an important component of diagnostics and is aimed at defining the methods and principles for the enterprise management system. The results of the carried out organizational analysis allow defining the problems and «bottle necks» in the system of strategic management of Ukrainian railways as a whole and in different directions of their economic activities.

Hydrogeological conceptual model development and numerical modelling using CONNECTFLOW, Forsmark modelling stage 2.3

Energy Technology Data Exchange (ETDEWEB)

Follin, Sven (SF GeoLogic AB, Taeby (Sweden)); Hartley, Lee; Jackson, Peter; Roberts, David (Serco TAP (United Kingdom)); Marsic, Niko (Kemakta Konsult AB, Stockholm (Sweden))

2008-05-15

of spatial variability of the hydraulic properties within soil layers and horizontal versus vertical anisotropy in the hydraulic conductivity of soils. For the deformation zones, the same prescription for assigning transmissivities was followed as for stage 2.2, but a new method for automating the local conditioning of the deformation zone transmissivity in the vicinity of a measurement interval was used. The numerical simulations carried out in stage 2.2 demonstrated that the three geological units: deformation zones, fracture domains and regolith, can be parameterised by means of single-hole hydraulic tests and satisfactorily transformed into heterogeneous hydraulic conductor domains (HCD), hydraulic rock mass domains (HRD) and hydraulic soil domains (HSD). This means that the conceptual model developed from the interpretation of Forsmark data in stage 2.2 can be used to predict a wide range of different types of data and processes such as 1) large-scale cross-hole test responses, 2) natural point-water heads in the bedrock and the regolith, and 3) hydrochemistry profiles along the many cored boreholes drilled in close proximity to the so called target area. It is noted that a primary idea of the confirmatory testing applied in stage 2.2 is that the same groundwater flow and solute transport model is used for each type of simulation to make it transparent that a single implementation of the conceptual model could be calibrated against all three types of field observations, although it may have been possible to improve the modelling of a particular data type by refining the model around a relevant observation borehole, for example. The conceptual modelling in stage 2.2 invoked a number of hypotheses, three of which that were addressed in stage 2.3 by means of complementary field investigations (hydraulic tests). The results from these investigations do not falsify (contradict) any of the three hypotheses, hence none of them should be rejected. In fact, the three

Ground-water monitoring under RCRA

International Nuclear Information System (INIS)

Coalgate, J.

1993-11-01

In developing a regulatory strategy for the disposal of hazardous waste under the Resource Conservation and Recovery Act (RCRA), protection of ground-water resources was the primary goal of the Environmental Protection Agency (EPA). EPA's ground-water protection strategy seeks to minimize the potential for hazardous wastes and hazardous constituents in waste placed in land disposel units to migrate into the environment. This is achieved through liquids management (limiting the placement of liquid wastes in or on the land, requiring the use of liners beneath waste, installing leachate collection systems and run-on and run-off controls, and covering wastes at closure). Ground-water monitoring serves to detect any failure in EPA's liquids management strategy so that ground-water contamination can be detected and addressed as soon as possible

Differences in adjustment by child developmental stage among caregivers of children with disorders of sex development

Directory of Open Access Journals (Sweden)

Hullmann Stephanie E

2011-11-01

Full Text Available Abstract Background The current study sought to compare levels of overprotection and parenting stress reported by caregivers of children with disorders of sex development at four different developmental stages. Methods Caregivers (N = 59 of children with disorders of sex development were recruited from specialty clinics and were asked to complete the Parent Protection Scale and Parenting Stress Index/Short Form as measures of overprotective behaviors and parenting stress, respectively. Results Analyses of covariance (ANCOVAs were conducted to examine differences between caregiver report of overprotection and parenting stress. Results revealed that caregivers of infants and toddlers exhibited more overprotective behaviors than caregivers of children in the other age groups. Further, caregivers of adolescents experienced significantly more parenting stress than caregivers of school-age children, and this effect was driven by personal distress and problematic parent-child interactions, rather than having a difficult child. Conclusions These results suggest that caregivers of children with disorders of sex development may have different psychosocial needs based upon their child's developmental stage and based upon the disorder-related challenges that are most salient at that developmental stage.

A Grounded Theory for Regional Development through the IT Offshoring Industry with the Triple-Helix Involvment

Science.gov (United States)

Villarreal de la Garza, Sonia

2011-01-01

The purpose of this qualitative grounded study was to explore the thoughts, experiences, and needs of potential clients and of the triple-helix members with the intention to establish a framework to support the development of the regional economy through the information technology (IT) and business processing outsourcing (BPO) offshoring industry.…

DEM Development from Ground-Based LiDAR Data: A Method to Remove Non-Surface Objects

Directory of Open Access Journals (Sweden)

Maneesh Sharma

2010-11-01

Full Text Available Topography and land cover characteristics can have significant effects on infiltration, runoff, and erosion processes on watersheds. The ability to model the timing and routing of surface water and erosion is affected by the resolution of the digital elevation model (DEM. High resolution ground-based Light Detecting and Ranging (LiDAR technology can be used to collect detailed topographic and land cover characteristic data. In this study, a method was developed to remove vegetation from ground-based LiDAR data to create high resolution DEMs. Research was conducted on intensively studied rainfall–runoff plots on the USDA-ARS Walnut Gulch Experimental Watershed in Southeast Arizona. LiDAR data were used to generate 1 cm resolution digital surface models (DSM for 5 plots. DSMs created directly from LiDAR data contain non-surface objects such as vegetation cover. A vegetation removal method was developed which used a slope threshold and a focal mean filter method to remove vegetation and create bare earth DEMs. The method was validated on a synthetic plot, where rocks and vegetation were added incrementally. Results of the validation showed a vertical error of ±7.5 mm in the final DEM.

Are stage IV vestibular schwannomas preoperatively different from other stages?

Science.gov (United States)

Tringali, Stéphane; Dubreuil, Christian; Zaouche, Sandra; Ferber-Viart, Chantal

2008-01-01

contrast, the occurrence of balance disorder was higher in Stage IV compared with all other stages. In clinical and paraclinical manifestation, Stage IV VS is different from the other stages. The PTA differences may be attributed to the younger age. Occurrence of clinical symptoms, ABR, and VNG pattern can be explained by the fact that Stage IV develops rapidly in the vestibular, rather than the cochlear nerve and by the fact that larger tumors can be cerebellar compression. This has been confirmed by the higher occurrence of balance disorders in Stage IV and the lower occurrence of tinnitus with similar hearing loss in all stages.

Development of Response Spectral Ground Motion Prediction Equations from Empirical Models for Fourier Spectra and Duration of Ground Motion

Science.gov (United States)

Bora, S. S.; Scherbaum, F.; Kuehn, N. M.; Stafford, P.; Edwards, B.

2014-12-01

In a probabilistic seismic hazard assessment (PSHA) framework, it still remains a challenge to adjust ground motion prediction equations (GMPEs) for application in different seismological environments. In this context, this study presents a complete framework for the development of a response spectral GMPE easily adjustable to different seismological conditions; and which does not suffer from the technical problems associated with the adjustment in response spectral domain. Essentially, the approach consists of an empirical FAS (Fourier Amplitude Spectrum) model and a duration model for ground motion which are combined within the random vibration theory (RVT) framework to obtain the full response spectral ordinates. Additionally, FAS corresponding to individual acceleration records are extrapolated beyond the frequency range defined by the data using the stochastic FAS model, obtained by inversion as described in Edwards & Faeh, (2013). To that end, an empirical model for a duration, which is tuned to optimize the fit between RVT based and observed response spectral ordinate, at each oscillator frequency is derived. Although, the main motive of the presented approach was to address the adjustability issues of response spectral GMPEs; comparison, of median predicted response spectra with the other regional models indicate that presented approach can also be used as a stand-alone model. Besides that, a significantly lower aleatory variability (σbrands it to a potentially viable alternative to the classical regression (on response spectral ordinates) based GMPEs for seismic hazard studies in the near future. The dataset used for the presented analysis is a subset of the recently compiled database RESORCE-2012 across Europe, Middle East and the Mediterranean region.

Trust Development With the Spanish-Speaking Mexican American Patient: A Grounded Theory Study.

Science.gov (United States)

Jones, Sharon M

2018-06-01

Interpersonal trust between patient and nurse is important in patient-centered care. Trust development may be more difficult if the patient and nurse do not speak the same language. In this grounded theory study, Spanish-speaking Mexican American adults ( n = 20) hospitalized on a medical-surgical or obstetric unit in the Midwestern United States were interviewed. Through data analysis, a model of how trust develops between nurse and patient revealed eight categories and the core category Caring for Me Well Even When Not Understanding Me. The beginning phase had four categories: Asking for Help, Bothering, Communicating, and Understanding. The middle phase had two categories: Platicando (chatting) and Being Available. The end point category was Having Trust, and outcomes were Feeling Comfortable and Feeling Supported. The language barrier was a hindrance to trust development but the nurse's way of being (personality) was more important. Therefore, the patient did develop trust with nurses who did not speak Spanish.

Development of dog-like retrieving capability in a ground robot

Science.gov (United States)

MacKenzie, Douglas C.; Ashok, Rahul; Rehg, James M.; Witus, Gary

2013-01-01

This paper presents the Mobile Intelligence Team's approach to addressing the CANINE outdoor ground robot competition. The competition required developing a robot that provided retrieving capabilities similar to a dog, while operating fully autonomously in unstructured environments. The vision team consisted of Mobile Intelligence, the Georgia Institute of Technology, and Wayne State University. Important computer vision aspects of the project were the ability to quickly learn the distinguishing characteristics of novel objects, searching images for the object as the robot drove a search pattern, identifying people near the robot for safe operations, correctly identify the object among distractors, and localizing the object for retrieval. The classifier used to identify the objects will be discussed, including an analysis of its performance, and an overview of the entire system architecture presented. A discussion of the robot's performance in the competition will demonstrate the system's successes in real-world testing.

Professional Socialization of Iranian BSN Students: A Grounded Theory Study.

Science.gov (United States)

Dinmohammadi, Mohammad Reza; Peyrovi, Hamid; Mehrdad, Neda

2017-12-01

Introduction: Professional socialization is a critical aspect of nursing students' development, which begins with entry into the nursing program and continues when their professional practice begins. The aim of this study was to explore the socialization of Iranian BSN students in the nursing profession. Methods: An exploratory qualitative approach utilizing Straussian version of the grounded theory (1998) method was used. Individual in-depth semi-structured interviews were undertaken with 14 participants chosen from two large nursing schools in an urban area through purposive and theoretical sampling. The data were analyzed, using the constant comparative method. Results: Five main categories and eleven subcategories emerged and integrated around one core category. Professional metamorphosis as the core variable was a complex and interrelated process (consisting of three stages: dependence, disintegration, and integration) with dynamic, ongoing, and personal features influenced by professional and extra-professional context. The students assumed a passive role in the initial of their studies. However, during the last year of the educational program, they gradually involved actively in dealing with own personal and professional issues. Conclusion: This study introduced "professional metamorphosis of BSN students" as a substantive grounded theory in the socio-cultural context of the health care system in Iran. During this process, students move from outsider personal position to insider professional position. The nurse educators and administrators may develop effective educational interventions to promote professional socialization of students with an understanding of the promoting and driving forces influencing socialization.

The Life Cycle Completed. Extended Version with New Chapters on the Ninth Stage of Development by Joan M. Erikson.

Science.gov (United States)

Erikson, Erik H.

This expanded edition of a 1982 book by Erik Erikson summarizes his work on the stages of the human life cycle, including chapters on psychosexuality and the cycle of generations, major stages in psychosocial development, and ego and ethos. An additional chapter on the ninth stage sets forth his philosophy on old age--i.e. the 80s and 90s--and how…

Ground Truth Annotation in T Analyst

DEFF Research Database (Denmark)

2015-01-01

This video shows how to annotate the ground truth tracks in the thermal videos. The ground truth tracks are produced to be able to compare them to tracks obtained from a Computer Vision tracking approach. The program used for annotation is T-Analyst, which is developed by Aliaksei Laureshyn, Ph...

Exergy analysis of a two-stage ground source heat pump with a vertical bore for residential space conditioning under simulated occupancy

International Nuclear Information System (INIS)

Ally, Moonis R.; Munk, Jeffrey D.; Baxter, Van D.; Gehl, Anthony C.

2015-01-01

Highlights: • Exergy and energy analysis of a vertical-bore ground source heat pump over a 12-month period is presented. • The ground provided more than 75% of the heating energy. • Performance metrics are presented. • Sources of systemic inefficiency are identified and prioritized using Exergy analysis. • Understanding performance metrics is vital for judicial use of renewable energy. - Abstract: This twelve-month field study analyzes the performance of a 7.56 W (2.16-ton) water-to-air-ground source heat pump (WA-GSHP) to satisfy domestic space conditioning loads in a 253 m 2 house in a mixed-humid climate in the United States. The practical feasibility of using the ground as a source of renewable energy is clearly demonstrated. Better than 75% of the energy needed for space heating was extracted from the ground. The average monthly electricity consumption for space conditioning was only 40 kW h at summer and winter thermostat set points of 24.4 °C and 21.7 °C, respectively. The WA-GSHP shared the same 94.5 m vertical bore ground loop with a separate water-to-water ground-source heat pump (WW-GSHP) for meeting domestic hot water needs in the same house. Sources of systemic irreversibility, the main cause of lost work, are identified using Exergy and energy analysis. Quantifying the sources of Exergy and energy losses is essential for further systemic improvements. The research findings suggest that the WA-GSHPs are a practical and viable technology to reduce primary energy consumption and greenhouse gas emissions under the IECC 2012 Standard, as well as the European Union (EU) 2020 targets of using renewable energy resources

Ventromedial prefrontal cortex damage does not impair the development and use of common ground in social interaction: implications for cognitive theory of mind.

Science.gov (United States)

Gupta, Rupa; Tranel, Daniel; Duff, Melissa C

2012-01-01

During conversation, interactants draw on their shared communicative context and history ("common ground") to help decide what to say next, tailoring utterances based on their knowledge of what the listener knows. The use of common ground draws on an understanding of the thoughts and feelings of others to create and update a model of what is known by the other person, employing cognitive processes such as theory of mind. We tested the hypothesis that the ventromedial prefrontal cortex (vmPFC), a neural region involved in processing and interpreting social and emotional information, would be critical for the development and use of common ground. We studied seven patients with bilateral vmPFC damage and seven age-, sex-, and education-matched healthy comparison participants, each interacting with a familiar partner. Across 24 trials, participants verbally directed their partners how to arrange a set of 12 abstract tangram cards. Our hypothesis was not supported: the vmPFC and healthy comparison groups showed similar development and use of common ground, evident in reduction in time and words used to describe the cards, similar increases in the use of definite references (e.g., the horse), and comparable use of verbal play (playful language) in their interactions. These results argue against the idea that the vmPFC is critical for the development and use of common ground in social interaction. We propose that a cognitive and neuroanatomical bifurcation in theory of mind processes may explain this outcome. The vmPFC may be important for affective theory of mind (the ability to understand another's feelings); however, the development and use of common ground in social interaction may place higher demands on the ability to understand another's knowledge, or cognitive theory of mind, which may not require the vmPFC. Copyright © 2011 Elsevier Ltd. All rights reserved.

Uranium isotopic disequilibrium in ground water as an indicator of anomalies

International Nuclear Information System (INIS)

Osmond, J.K.; Cowart, J.B.; Ivanovich, M.

1983-01-01

Because of the unique elemental and isotopic properties of uranium, ground water surveys are a most appropriate approach to prospecting for surficial and secondary uranium deposits. Uranium4+ is generally immobile, but in oxidising and carbonate bearing waters U 6 + is mobile and conservative. Uranium 234 is the radiogenic daughter of 238 U. The intervening α-decay event causes recoil displacements and radioactive disequilibrium between the two isotopes in open systems such as surficial aquifers. Extreme variations in dissolved uranium composition of ground waters combined with significant variations in the ratio 234 U/ 238 U are indicative of the proximity and stage of evolution of secondary deposits. (author)

A grounded theory model for reducing stigma in health professionals in Canada.

Science.gov (United States)

Knaak, S; Patten, S

2016-08-01

The Mental Health Commission of Canada was formed as a national catalyst for improving the mental health system. One of its initiatives is Opening Minds (OM), whose mandate is to reduce mental health-related stigma. This article reports findings from a qualitative study on antistigma interventions for healthcare providers, which includes a process model articulating key stages and strategies for implementing successful antistigma programmes. The study employed a grounded theory methodology. Data collection involved in-depth interviews with programme stakeholders, direct observation of programmes, a review of programme documents, and qualitative feedback from programme participants. Analysis proceeded via the constant comparison method. A model was generated to visually present key findings. Twenty-three in-depth interviews were conducted representing 18 different programmes. Eight programmes were observed directly, 48 programme documents were reviewed, and data from 1812 programme participants were reviewed. The analysis led to a four-stage process model for implementing successful antistigma programmes targeting healthcare providers, informed by the basic social process 'targeting the roots of healthcare provider stigma'. The process model developed through this research may function as a tool to help guide the development and implementation of antistigma programmes in healthcare contexts. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Removal of micropollutants with coarse-ground activated carbon for enhanced separation with hydrocyclone classifiers.

Science.gov (United States)

Otto, N; Platz, S; Fink, T; Wutscherk, M; Menzel, U

2016-01-01

One key technology to eliminate organic micropollutants (OMP) from wastewater effluent is adsorption using powdered activated carbon (PAC). To avoid a discharge of highly loaded PAC particles into natural water bodies a separation stage has to be implemented. Commonly large settling tanks and flocculation filters with the application of coagulants and flocculation aids are used. In this study, a multi-hydrocyclone classifier with a downstream cloth filter has been investigated on a pilot plant as a space-saving alternative with no need for a dosing of chemical additives. To improve the separation, a coarser ground PAC type was compared to a standard PAC type with regard to elimination results of OMP as well as separation performance. With a PAC dosing rate of 20 mg/l an average of 64.7 wt% of the standard PAC and 79.5 wt% of the coarse-ground PAC could be separated in the hydrocyclone classifier. A total average separation efficiency of 93-97 wt% could be reached with a combination of both hydrocyclone classifier and cloth filter. Nonetheless, the OMP elimination of the coarse-ground PAC was not sufficient enough to compete with the standard PAC. Further research and development is necessary to find applicable coarse-grained PAC types with adequate OMP elimination capabilities.

Basin scale management of surface and ground water

International Nuclear Information System (INIS)

Tracy, J.C.; Al-Sharif, M.

1993-01-01

An important element in the economic development of many regions of the Great Plains is the availability of a reliable water supply. Due to the highly variable nature of the climate through out much of the Great Plains region, non-controlled stream flow rates tend to be highly variable from year to year. Thus, the primary water supply has tended towards developing ground water aquifers. However, in regions where shallow ground water is extracted for use, there exists the potential for over drafting aquifers to the point of depleting hydraulically connected stream flows, which could adversely affect the water supply of downstream users. To prevent the potential conflict that can arise when a basin's water supply is being developed or to control the water extractions within a developed basin requires the ability to predict the effect that water extractions in one region will have on water extractions from either surface or ground water supplies else where in the basin. This requires the ability to simulate ground water levels and stream flows on a basin scale as affected by changes in water use, land use practices and climatic changes within the basin. The outline for such a basin scale surface water-ground water model has been presented in Tracy (1991) and Tracy and Koelliker (1992), and the outline for the mathematical programming statement to aid in determining the optimal allocation of water on a basin scale has been presented in Tracy and Al-Sharif (1992). This previous work has been combined into a computer based model with graphical output referred to as the LINOSA model and was developed as a decision support system for basin managers. This paper will present the application of the LINOSA surface-ground water management model to the Rattlesnake watershed basin that resides within Ground Water Management District Number 5 in south central Kansas

Fish egg predation by Baltic sprat and herring: do species characteristics and development stage matter?

DEFF Research Database (Denmark)

Neumann, Viola; Köster, Fritz; Eero, Margit

2017-01-01

Predation of eggs by clupeids has been identified as a major factor contributing to early life stage mortality of Baltic cod. We used data from ichthyoplankton sampling and clupeid stomach analyses to investigate whether eggs of other fish species are to a similar extent subject to predation...... generally negatively selected by both predators, while fish eggs were non-selectively consumed in summer. Predation is suggested to account for a large fraction of mortality of cod eggs at older stages, i.e. those eggs, which have survived the often detrimentally low oxygen concentration in and below...... the permanent halocline. The consumption rates of sprat eggs at all development stages relative to production rates were considerably lower compared to cod, suggesting that egg predation is of lesser importance for sprat recruitment....

Ground-Water Availability in the United States

Science.gov (United States)

Reilly, Thomas E.; Dennehy, Kevin F.; Alley, William M.; Cunningham, William L.

2008-01-01

Ground water is among the Nation's most important natural resources. It provides half our drinking water and is essential to the vitality of agriculture and industry, as well as to the health of rivers, wetlands, and estuaries throughout the country. Large-scale development of ground-water resources with accompanying declines in ground-water levels and other effects of pumping has led to concerns about the future availability of ground water to meet domestic, agricultural, industrial, and environmental needs. The challenges in determining ground-water availability are many. This report examines what is known about the Nation's ground-water availability and outlines a program of study by the U.S. Geological Survey Ground-Water Resources Program to improve our understanding of ground-water availability in major aquifers across the Nation. The approach is designed to provide useful regional information for State and local agencies who manage ground-water resources, while providing the building blocks for a national assessment. The report is written for a wide audience interested or involved in the management, protection, and sustainable use of the Nation's water resources.

Modeling of earthquake ground motion in the frequency domain

Science.gov (United States)

Thrainsson, Hjortur

In recent years, the utilization of time histories of earthquake ground motion has grown considerably in the design and analysis of civil structures. It is very unlikely, however, that recordings of earthquake ground motion will be available for all sites and conditions of interest. Hence, there is a need for efficient methods for the simulation and spatial interpolation of earthquake ground motion. In addition to providing estimates of the ground motion at a site using data from adjacent recording stations, spatially interpolated ground motions can also be used in design and analysis of long-span structures, such as bridges and pipelines, where differential movement is important. The objective of this research is to develop a methodology for rapid generation of horizontal earthquake ground motion at any site for a given region, based on readily available source, path and site characteristics, or (sparse) recordings. The research includes two main topics: (i) the simulation of earthquake ground motion at a given site, and (ii) the spatial interpolation of earthquake ground motion. In topic (i), models are developed to simulate acceleration time histories using the inverse discrete Fourier transform. The Fourier phase differences, defined as the difference in phase angle between adjacent frequency components, are simulated conditional on the Fourier amplitude. Uniformly processed recordings from recent California earthquakes are used to validate the simulation models, as well as to develop prediction formulas for the model parameters. The models developed in this research provide rapid simulation of earthquake ground motion over a wide range of magnitudes and distances, but they are not intended to replace more robust geophysical models. In topic (ii), a model is developed in which Fourier amplitudes and Fourier phase angles are interpolated separately. A simple dispersion relationship is included in the phase angle interpolation. The accuracy of the interpolation

Research on Integrated Geophysics Detect Potential Ground Fissure in City

Science.gov (United States)

Qian, R.

2017-12-01

North China confined aquifer lied 70 to 200 meters below the earth's surface has been exploited for several decades, which resulted in confined water table declining and has generated a mass of ground fissure. Some of them has reached the surface and the other is developing. As it is very difficult to stop the ground fissure coming into being, measures of avoiding are often taken. It brings great potential risk to urban architecture and municipal engineering. It is very important to find out specific distribution and characteristic of potential ground fissure in city with high resolution. The ground fissure is concealed, therefor, geophysical method is an important technology to detecting concealed ground fissure. However, it is very difficult to detect the characteristics of the superficial part of ground fissure directly, as it lies dozens of meters below and has only scores of centimeters fault displacement. This paper studies applied ground penetration radar, surface wave and shallow refleciton seismic to detect ground fissure. It sets up model of surface by taking advantage of high resolution of ground penetrating radar data, constrains Reilay wave inversion and improves its resolution. The high resolution reflection seismic is good at detecting the geology structure. The data processing and interpretation technique is developmented to avoid the pitfall and improve the aliability of the rusult. The experiment has been conducted in Shunyi District, Beijing in 2016. 5 lines were settled to collect data of integrated geophysical method. Development zone of concealed ground fissure was found and its ultra shallow layer location was detected by ground penetrating radar. A trial trench of 6 meters in depth was dug and obvious ground fissure development was found. Its upper end was 1.5 meters beneath the earth's surface with displacement of 0.3 meters. The favorable effect of this detection has provided a new way for detecting ground fissure in cities of China, such

Antlers on the Arctic Refuge: capturing multi-generational patterns of calving ground use from bones on the landscape.

Science.gov (United States)

Miller, Joshua H; Druckenmiller, Patrick; Bahn, Volker

2013-05-22

Bone accumulations faithfully record historical ecological data on animal communities, and owing to millennial-scale bone survival on high-latitude landscapes, have exceptional potential for extending records on arctic ecosystems. For the Porcupine Caribou Herd, maintaining access to calving grounds on the Arctic National Wildlife Refuge (ANWR, Alaska) is a central management concern. However, variability in calving ground geography over the 30+ years of monitoring suggests establishing the impacts of climate change and potential petroleum development on future calving success could benefit from extended temporal perspectives. Using accumulations of female antlers (shed within days of calving) and neonatal skeletons, we test if caribou calving grounds develop measureable and characteristic bone accumulations and if skeletal data may be helpful in establishing a fuller, historically integrated understanding of landscape and habitat needs. Bone surveys of an important ANWR calving area reveal abundant shed antlers (reaching 10(3) km(-2)) and high proportional abundance of newborn skeletal individuals (up to 60% neonate). Openly vegetated riparian terraces, which compose less than 10 per cent of ANWR calving grounds, yield significantly higher antler concentrations than more abundant habitats traditionally viewed as primary calving terrain. Differences between habitats appear robust to potential differences in bone visibility. The distribution of antler weathering stages mirrors known multi-decadal calving histories and highlights portions of the antler accumulation that probably significantly extends records of calving activity. Death assemblages offer historically integrated ecological data valuable for the management and conservation of faunas across polar latitudes.

Development of an optochemical sensor for continuous reversible determination of nitrate in drinking water and ground water

International Nuclear Information System (INIS)

Lumpp, R.

1993-09-01

An optochemical sensor has been developed for continuous reversible determination of nitrate in drinking water and ground water. The sensor is based on the combination of the anion selective liquid ion exchanger Ni(II[bathophenanthroline] 3 2+ with phenolsulfonephtalein dyes in a polyvinylchloride membrane. (orig.) [de

Reusable launch vehicles, enabling technology for the development of advanced upper stages and payloads

International Nuclear Information System (INIS)

Metzger, John D.

1998-01-01

In the near future there will be classes of upper stages and payloads that will require initial operation at a high-earth orbit to reduce the probability of an inadvertent reentry that could result in a detrimental impact on humans and the biosphere. A nuclear propulsion system, such as was being developed under the Space Nuclear Thermal Propulsion (SNTP) Program, is an example of such a potential payload. This paper uses the results of a reusable launch vehicle (RLV) study to demonstrate the potential importance of a Reusable Launch Vehicle (RLV) to test and implement an advanced upper stage (AUS) or payload in a safe orbit and in a cost effective and reliable manner. The RLV is a horizontal takeoff and horizontal landing (HTHL), two-stage-to-orbit (TSTO) vehicle. The results of the study shows that an HTHL is cost effective because it implements airplane-like operation, infrastructure, and flight operations. The first stage of the TSTO is powered by Rocket-Based-Combined-Cycle (RBCC) engines, the second stage is powered by a LOX/LH rocket engine. The TSTO is used since it most effectively utilizes the capability of the RBCC engine. The analysis uses the NASA code POST (Program to Optimize Simulated Trajectories) to determine trajectories and weight in high-earth orbit for AUS/advanced payloads. Cost and reliability of an RLV versus current generation expandable launch vehicles are presented

The stages of modernism in Serbian music

Directory of Open Access Journals (Sweden)

Milin Melita

2006-01-01

(Mihovil Logar, Predrag Milošević, Dragutin Čolić, Ljubica Marić, Vojislav Vučković, Milan Ristić. The third stage (1951–1970 followed immediately after the era of Socialist Realism, which involved the rediscovery of the pre- World War II Western modernism and prepared the ground for contemporary avant-garde developments almost non-existent before 1961 (Milan Ristić, Dušan Radić, Dejan Despić Vladan Radovanović, Enriko Josif, Stanojlo Rajičić, Vasilije Mokranjac Aleksandar Obradović, Ljubica Marić, Rajko Maksimović. The fourth stage (1956–1980 was the period during which the post-World War II avant-garde developments found their home amongst Serbian composers, some of them conceived almost simultaneously with but independent of the current progressive development in the rest of the world (Vladan Radovanović Aleksandar Obradović, Petar Ozgijan, Petar Bergamo, Srdjan Hofman, the group Opus 4.

Funding opportunities for investigators in the early stages of career development.

Science.gov (United States)

Sumandea, C Amelia; Balke, C William

2009-03-10

Many sources of advice and guidance are available to the early career investigator. Generally, mentors serve as the primary source of information, although program and review officers are the most underutilized resources. This article organizes these opportunities to enable early career investigators to plot a rational trajectory for career success. A list of the major agencies that provide grant support for early career investigators is included. In addition, funding opportunities are organized on the basis of the stage in career development pathway and the type of terminal degree.

Development of eggs and the planktonic stages of salmon lice (Lepeophtheirus salmonis) at low temperatures

NARCIS (Netherlands)

Boxaspen, Karin; Næss, Tore

2000-01-01

To verify if and to what extent egg and nauplii development of the salmon lice take place during winter, the development from egg to the copepodid stage at 2,3,4,5 and 10°C was examined. Newly extruded egg strings from a winter population of salmon lice were individually placed in 6 ml stagnant

Genome-Wide DNA Methylation Patterns of Bovine Blastocysts Developed In Vivo from Embryos Completed Different Stages of Development In Vitro.

Directory of Open Access Journals (Sweden)

Dessie Salilew-Wondim

Full Text Available Early embryonic loss and altered gene expression in in vitro produced blastocysts are believed to be partly caused by aberrant DNA methylation. However, specific embryonic stage which is sensitive to in vitro culture conditions to alter the DNA methylation profile of the resulting blastocysts remained unclear. Therefore, the aim of this study was to investigate the stage specific effect of in vitro culture environment on the DNA methylation response of the resulting blastocysts. For this, embryos cultured in vitro until zygote (ZY, 4-cell (4C or 16-cell (16C were transferred to recipients and the blastocysts were recovery at day 7 of the estrous cycle. Another embryo group was cultured in vitro until blastocyst stage (IVP. Genome-wide DNA methylation profiles of ZY, 4C, 16C and IVP blastocyst groups were then determined with reference to blastocysts developed completely under in vivo condition (VO using EmbryoGENE DNA Methylation Array. To assess the contribution of methylation changes on gene expression patterns, the DNA methylation data was superimposed to the transcriptome profile data. The degree of DNA methylation dysregulation in the promoter and/or gene body regions of the resulting blastocysts was correlated with successive stages of development the embryos advanced under in vitro culture before transfer to the in vivo condition. Genomic enrichment analysis revealed that in 4C and 16C blastocyst groups, hypermethylated loci were outpacing the hypomethylated ones in intronic, exonic, promoter and proximal promoter regions, whereas the reverse was observed in ZY blastocyst group. However, in the IVP group, as much hypermethylated as hypomethylated probes were detected in gene body and promoter regions. In addition, gene ontology analysis indicated that differentially methylated regions were found to affected several biological functions including ATP binding in the ZY group, programmed cell death in the 4C, glycolysis in 16C and genetic

Reading Skills of Students with Speech Sound Disorders at Three Stages of Literacy Development

Science.gov (United States)

Skebo, Crysten M.; Lewis, Barbara A.; Freebairn, Lisa A.; Tag, Jessica; Ciesla, Allison Avrich; Stein, Catherine M.

2013-01-01

Purpose: The relationship between phonological awareness, overall language, vocabulary, and nonlinguistic cognitive skills to decoding and reading comprehension was examined for students at 3 stages of literacy development (i.e., early elementary school, middle school, and high school). Students with histories of speech sound disorders (SSD) with…

Agricultural Land Use Determines the Trait Composition of Ground Beetle Communities.

Directory of Open Access Journals (Sweden)

Helena I Hanson

Full Text Available In order to improve biological control of agricultural pests, it is fundamental to understand which factors influence the composition of natural enemies in agricultural landscapes. In this study, we aimed to understand how agricultural land use affects a number of different traits in ground beetle communities to better predict potential consequences of land-use change for ecosystem functioning. We studied ground beetles in fields with different agricultural land use ranging from frequently managed sugar beet fields, winter wheat fields to less intensively managed grasslands. The ground beetles were collected in emergence tents that catch individuals overwintering locally in different life stages and with pitfall traps that catch individuals that could have a local origin or may have dispersed into the field. Community weighted mean values for ground beetle traits such as body size, flight ability and feeding preference were estimated for each land-use type and sampling method. In fields with high land-use intensity the average body length of emerging ground beetle communities was lower than in the grasslands while the average body length of actively moving communities did not differ between the land-use types. The proportion of ground beetles with good flight ability or a carnivorous diet was higher in the crop fields as compared to the grasslands. Our study highlights that increasing management intensity reduces the average body size of emerging ground beetles and the proportion of mixed feeders. Our results also suggest that the dispersal ability of ground beetles enables them to compensate for local management intensities.

Agricultural Land Use Determines the Trait Composition of Ground Beetle Communities.

Science.gov (United States)

Hanson, Helena I; Palmu, Erkki; Birkhofer, Klaus; Smith, Henrik G; Hedlund, Katarina

2016-01-01

In order to improve biological control of agricultural pests, it is fundamental to understand which factors influence the composition of natural enemies in agricultural landscapes. In this study, we aimed to understand how agricultural land use affects a number of different traits in ground beetle communities to better predict potential consequences of land-use change for ecosystem functioning. We studied ground beetles in fields with different agricultural land use ranging from frequently managed sugar beet fields, winter wheat fields to less intensively managed grasslands. The ground beetles were collected in emergence tents that catch individuals overwintering locally in different life stages and with pitfall traps that catch individuals that could have a local origin or may have dispersed into the field. Community weighted mean values for ground beetle traits such as body size, flight ability and feeding preference were estimated for each land-use type and sampling method. In fields with high land-use intensity the average body length of emerging ground beetle communities was lower than in the grasslands while the average body length of actively moving communities did not differ between the land-use types. The proportion of ground beetles with good flight ability or a carnivorous diet was higher in the crop fields as compared to the grasslands. Our study highlights that increasing management intensity reduces the average body size of emerging ground beetles and the proportion of mixed feeders. Our results also suggest that the dispersal ability of ground beetles enables them to compensate for local management intensities.

Extraction and textural characterization of above-ground areas from aerial stereo pairs: a quality assessment

Science.gov (United States)

Baillard, C.; Dissard, O.; Jamet, O.; Maître, H.

Above-ground analysis is a key point to the reconstruction of urban scenes, but it is a difficult task because of the diversity of the involved objects. We propose a new method to above-ground extraction from an aerial stereo pair, which does not require any assumption about object shape or nature. A Digital Surface Model is first produced by a stereoscopic matching stage preserving discontinuities, and then processed by a region-based Markovian classification algorithm. The produced above-ground areas are finally characterized as man-made or natural according to the grey level information. The quality of the results is assessed and discussed.

AN INTEGRATED MODEL FOR MANAGING INNOVATION IN THE EARLY STAGES OF NEW PRODUCT DEVELOPMENT IN SMES(RIKON Group)

OpenAIRE

Flinders, Clare; Lynch, Patrick; Holden, Mary T.

2009-01-01

This paper centralises the management of innovation in the early stages of the new product development (NPD) process. The purpose of this paper is to describe the critical episodes that enabled an SME to successfully manage the development of new product concepts from inception and, in so doing, presents implementable guidelines that can be used by SMEs to manage the delivery of creative and attractive new product concepts in the early stages of NPD. Action research was used to conduct a thre...

Tools for Reactive Distillation Column Design: Graphical and Stage-to-Stage Computation Methods

DEFF Research Database (Denmark)

Sanchez Daza, O.; Cisneros, Eduardo Salvador P.; Hostrup, Martin

2001-01-01

Based on the element mass balance concept, a graphical design method and a stage-to-stage multicomponent design method for reactive distillation columns have been developed. For distillation columns comprising reactive and non-reactive stages, a simple design strategy based on reactive and non......-reactive bubble point calculations is proposed. This strategy tracks the conversion and temperature between the feed and the end stages of the column. An illustrative example highlights the verification of the design strategy through rigorous simulation....

Intelligent systems for KSC ground processing

Science.gov (United States)

Heard, Astrid E.

1992-01-01

The ground processing and launch of Shuttle vehicles and their payloads is the primary task of Kennedy Space Center. It is a process which is largely manual and contains little inherent automation. Business is conducted today much as it was during previous NASA programs such as Apollo. In light of new programs and decreasing budgets, NASA must find more cost effective ways in which to do business while retaining the quality and safety of activities. Advanced technologies including artificial intelligence could cut manpower and processing time. This paper is an overview of the research and development in Al technology at KSC with descriptions of the systems which have been implemented, as well as a few under development which are promising additions to ground processing software. Projects discussed cover many facets of ground processing activities, including computer sustaining engineering, subsystem monitor and diagnosis tools and launch team assistants. The deployed Al applications have proven an effectiveness which has helped to demonstrate the benefits of utilizing intelligent software in the ground processing task.

Arbuscular mycorrhizal fungi affect both penetration and further life stage development of root-knot nematodes in tomato.

Science.gov (United States)

Vos, Christine; Geerinckx, Katleen; Mkandawire, Rachel; Panis, Bart; De Waele, Dirk; Elsen, Annemie

2012-02-01

The root-knot nematode Meloidogyne incognita poses a worldwide threat to agriculture, with an increasing demand for alternative control options since most common nematicides are being withdrawn due to environmental concerns. The biocontrol potential of arbuscular mycorrhizal fungi (AMF) against plant-parasitic nematodes has been demonstrated, but the modes of action remain to be unraveled. In this study, M. incognita penetration of second-stage juveniles at 4, 8 and 12 days after inoculation was compared in tomato roots (Solanum lycopersicum cv. Marmande) pre-colonized or not by the AMF Glomus mosseae. Further life stage development of the juveniles was also observed in both control and mycorrhizal roots at 12 days, 3 weeks and 4 weeks after inoculation by means of acid fuchsin staining. Penetration was significantly lower in mycorrhizal roots, with a reduction up to 32%. Significantly lower numbers of third- and fourth-stage juveniles and females accumulated in mycorrhizal roots, at a slower rate than in control roots. The results show for the first time that G. mosseae continuously suppresses root-knot nematodes throughout their entire early infection phase of root penetration and subsequent life stage development.

Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development

Directory of Open Access Journals (Sweden)

Kyle J. Beauchemin

2016-08-01

Full Text Available To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ. Using Principal Component Analysis and least squares regression modeling, we identified both strain-independent and strain-dependent patterns of gene expression. The 4,683 genes contributing to the strain-independent expression patterns were used to define a murine Developing Lung Characteristic Subtranscriptome (mDLCS. Regression modeling of the Principal Components supported the four canonical stages of mammalian embryonic lung development (embryonic, pseudoglandular, canalicular, saccular defined previously by morphology and histology. For postnatal alveolar development, the regression model was consistent with four stages of alveolarization characterized by episodic transcriptional activity of genes related to pulmonary vascularization. Genes expressed in a strain-dependent manner were enriched for annotations related to neurogenesis, extracellular matrix organization, and Wnt signaling. Finally, a comparison of mouse and human transcriptomics from pre-natal stages of lung development revealed conservation of pathways associated with cell cycle, axon guidance, immune function, and metabolism as well as organism-specific expression of genes associated with extracellular matrix organization and protein modification. The mouse lung development transcriptome data generated for this study serves as a unique reference set to identify genes and pathways essential for normal mammalian lung development and for investigations into the developmental origins of respiratory disease and cancer. The gene expression data are available from the Gene Expression Omnibus (GEO archive (GSE74243. Temporal expression patterns of mouse genes can be investigated using a study specific web resource (http://lungdevelopment.jax.org.

Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development.

Science.gov (United States)

Beauchemin, Kyle J; Wells, Julie M; Kho, Alvin T; Philip, Vivek M; Kamir, Daniela; Kohane, Isaac S; Graber, Joel H; Bult, Carol J

2016-01-01

To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ). Using Principal Component Analysis and least squares regression modeling, we identified both strain-independent and strain-dependent patterns of gene expression. The 4,683 genes contributing to the strain-independent expression patterns were used to define a murine Developing Lung Characteristic Subtranscriptome (mDLCS). Regression modeling of the Principal Components supported the four canonical stages of mammalian embryonic lung development (embryonic, pseudoglandular, canalicular, saccular) defined previously by morphology and histology. For postnatal alveolar development, the regression model was consistent with four stages of alveolarization characterized by episodic transcriptional activity of genes related to pulmonary vascularization. Genes expressed in a strain-dependent manner were enriched for annotations related to neurogenesis, extracellular matrix organization, and Wnt signaling. Finally, a comparison of mouse and human transcriptomics from pre-natal stages of lung development revealed conservation of pathways associated with cell cycle, axon guidance, immune function, and metabolism as well as organism-specific expression of genes associated with extracellular matrix organization and protein modification. The mouse lung development transcriptome data generated for this study serves as a unique reference set to identify genes and pathways essential for normal mammalian lung development and for investigations into the developmental origins of respiratory disease and cancer. The gene expression data are available from the Gene Expression Omnibus (GEO) archive (GSE74243). Temporal expression patterns of mouse genes can be investigated using a study specific web resource (http://lungdevelopment.jax.org).

Ground Control System Description Document

International Nuclear Information System (INIS)

Eric Loros

2001-01-01

The Ground Control System contributes to the safe construction and operation of the subsurface facility, including accesses and waste emplacement drifts, by maintaining the configuration and stability of the openings during construction, development, emplacement, and caretaker modes for the duration of preclosure repository life. The Ground Control System consists of ground support structures installed within the subsurface excavated openings, any reinforcement made to the rock surrounding the opening, and inverts if designed as an integral part of the system. The Ground Control System maintains stability for the range of geologic conditions expected at the repository and for all expected loading conditions, including in situ rock, construction, operation, thermal, and seismic loads. The system maintains the size and geometry of operating envelopes for all openings, including alcoves, accesses, and emplacement drifts. The system provides for the installation and operation of sensors and equipment for any required inspection and monitoring. In addition, the Ground Control System provides protection against rockfall for all subsurface personnel, equipment, and the engineered barrier system, including the waste package during the preclosure period. The Ground Control System uses materials that are sufficiently maintainable and that retain the necessary engineering properties for the anticipated conditions of the preclosure service life. These materials are also compatible with postclosure waste isolation performance requirements of the repository. The Ground Control System interfaces with the Subsurface Facility System for operating envelopes, drift orientation, and excavated opening dimensions, Emplacement Drift System for material compatibility, Monitored Geologic Repository Operations Monitoring and Control System for ground control instrument readings, Waste Emplacement/Retrieval System to support waste emplacement operations, and the Subsurface Excavation System

Cost Accounting of Venture Company Depending on the Stage of Its Life Cycle

OpenAIRE

Olha Usatenko

2015-01-01

The purpose of the article is to identify groups of costs that are inherent in life-cycle stages of venture companies and which directly are the objects of accounting. The author distinguishes stages of the life cycle of the venture company with an indication of the degree of risk and the need for venture capital, which determine the accounting tasks required to reflect it. The model of lifecycle accounting of venture company is grounded. The conventional range of expected return on the inves...

CONCEPTUAL DESIGN OF MONITORING AND CONTROL SUBSYSTEM FOR GNSS GROUND STATION

Directory of Open Access Journals (Sweden)

Seongkyun Jeong

2007-12-01

Full Text Available The Global Navigation Satellite System (GNSS becomes more important and is applied to various systems. Recently, the Galileo navigation system is being developed in Europe. Also, other countries like China, Japan and India are developing the global/regional navigation satellite system. As various global/regional navigation satellite systems are used, the navigation ground system gets more important for using the navigation system reasonably and efficiently. According to this trend, the technology of GNSS Ground Station (GGS is developing in many fields. The one of purposes for this study is to develop the high precision receiver for GNSS sensor station and to provide ground infrastructure for better performance services on navigation system. In this study, we consider the configuration of GNSS Ground Station and analyze function of Monitoring and Control subsystem which is a part of GNSS Ground Station. We propose Monitoring and Control subsystem which contains the navigation software for GNSS Ground System to monitor and control equipments in GNSS Ground Station, to spread the applied field of navigation system, and to provide improved navigation information to user.

Development of a decision aid for the treatment of benign prostatic hyperplasia: A four stage method using a Delphi consensus study.

Science.gov (United States)

Lamers, Romy E D; Cuypers, Maarten; Garvelink, Mirjam M; de Vries, Marieke; Bosch, J L H Ruud; Kil, Paul J M

2016-07-01

To develop a web-based decision aid (DA) for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH). From February-September 2014 we performed a four-stage development method: 1: Two-round Delphi consensus method among urologists, 2: Identifying patients' needs and expectations, 3: Development of DA content and structure, 4: Usability testing with LUTS/BPH patients. 1 (N=15): Dutch urologists reached consensus on 61% of the statements concerning users' criteria, decision options, structure, and medical content. 2 (N=24): Consensus was reached in 69% on statements concerning the need for improvement of information provision, the need for DA development and that the DA should clarify patients' preferences. 3: DA development based on results from stage 1 and stage 2. 4 (N=10): Pros of the DA were clear information provision, systematic design and easy to read and re-read. A LUTS/BPH DA containing VCEs(**) was developed in cooperation with urologists and patients following a structured 4 stage method and was stated to be well accepted. This method can be adopted for the development of DAs to support other medical decision issues. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A model to explain suicide by self-immolation among Iranian women: A grounded theory study.

Science.gov (United States)

Khankeh, Hamid Reza; Hosseini, Seyed Ali; Rezaie, Leeba; Shakeri, Jalal; Schwebel, David C

2015-11-01

Self-immolation is a common method of suicide among Iranian women. There are several contributing motives for attempting self-immolation, and exploration of the process of self-immolation incidents will help interventionists and clinicians develop prevention programs. A grounded theory study using face-to-face, recorded interviews was conducted with surviving self-immolated patients (n=14), their close relatives (n=5), and medical staff (n=8) in Kermanshah, Iran. Data were analyzed using constant comparison in open, axial, and selective coding stages. A conceptual model was developed to explain the relationships among the main categories extracted through the grounded theory study. Family conflicts emerged as the core category. Cultural context of self-immolated patients offered a contextual condition. Other important categories linked to the core category were mental health problems, distinct characteristics of the suicidal method, and self-immolation as a threat. The role of mental health problems as a causal condition was detected in different levels of the self-immolation process. Finally, adverse consequences of self-immolation emerged as having important impact. The conceptual model, derived through grounded theory study, can guide design of prevention programs. The pivotal role of family conflicts should be emphasized in mental health interventions. The impact of adverse consequences of self-immolation on further suicidal processes necessitates post-suicide prevention programs. Further research to design specific interventions is recommended. Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved.

Management Research and Grounded Theory: A review of grounded theorybuilding approach in organisational and management research.

Directory of Open Access Journals (Sweden)

Graham J.J. Kenealy, Ph.D.

2008-06-01

Full Text Available Grounded theory is a systematic methodology for the collection and analysis of data which was discovered by Glaser and Strauss in the 1960’s. The discovery of this method was first presented to the academic community in their book ‘The Discovery of Grounded Theory’ (1967 which still remains a primary point of reference for those undertaking qualitative research and grounded theory in particular. This powerful research method has become very popular in some research domains; whilst increasing in popularity it is still less prevalent in the field of organisational and management research particularly in its original form. This self reflexive paper sets out to explore the possibilities for this imbalance which takes the discussion onto the areas of methodological adaptation and training. It also enters the debate about access to research subjects and provides a succinct argument supporting the notion that grounded theory should simply be viewed as a method that develops empirically grounded conceptual theory.

SSE software test management STM capability: Using STM in the Ground Systems Development Environment (GSDE)

Science.gov (United States)

Church, Victor E.; Long, D.; Hartenstein, Ray; Perez-Davila, Alfredo

1992-01-01

This report is one of a series discussing configuration management (CM) topics for Space Station ground systems software development. It provides a description of the Software Support Environment (SSE)-developed Software Test Management (STM) capability, and discusses the possible use of this capability for management of developed software during testing performed on target platforms. This is intended to supplement the formal documentation of STM provided by the SEE Project. How STM can be used to integrate contractor CM and formal CM for software before delivery to operations is described. STM provides a level of control that is flexible enough to support integration and debugging, but sufficiently rigorous to insure the integrity of the testing process.

Staged, High-Pressure Oxy-Combustion Technology: Development and Scale-Up

Energy Technology Data Exchange (ETDEWEB)

Axelbaum, Richard [Washington Univ., St. Louis, MO (United States); Kumfer, Benjamin [Washington Univ., St. Louis, MO (United States); Gopan, Akshay [Washington Univ., St. Louis, MO (United States); Yang, Zhiwei [Washington Univ., St. Louis, MO (United States); Phillips, Jeff [Electric Power Research Inst. (EPRI), Palo Alto, CA (United States); Pint, Bruce [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-12-29

The immediate need for a high efficiency, low cost carbon capture process has prompted the recent development of pressurized oxy-combustion. With a greater combustion pressure the dew point of the flue gas is increased, allowing for effective integration of the latent heat of flue gas moisture into the Rankine cycle. This increases the net plant efficiency and reduces costs. A novel, transformational process, named Staged, Pressurized Oxy-Combustion (SPOC), achieves additional step changes in efficiency and cost reduction by significantly reducing the recycle of flue gas. The research and development activities conducted under Phases I and II of this project (FE0009702) include: SPOC power plant cost and performance modeling, CFD-assisted design of pressurized SPOC boilers, theoretical analysis of radiant heat transfer and ash deposition, boiler materials corrosion testing, construction of a 100 kWth POC test facility, and experimental testing. The results of this project have advanced the technology readiness level (TRL) of the SPOC technology from 1 to 5.

Affordable Development and Demonstration of a Small NTR engine and Stage: A Preliminary NASA, DOE, and Industry Assessment

Science.gov (United States)

Borowski, S. K.; Sefcik, R. J.; Fittje, J. E.; McCurdy, D. R.; Qualls, A. L.; Schnitzler, B. G; Werner, J.; Weitzberg, A.; Joyner, C. R.

2015-01-01

In FY'11, Nuclear Thermal Propulsion (NTP) was identified as a key propulsion option under the Advanced In-Space Propulsion (AISP) component of NASA's Exploration Technology Development and Demonstration (ETDD) program A strategy was outlined by GRC and NASA HQ that included 2 key elements -"Foundational Technology Development" followed by specific "Technology Demonstration" projects. The "Technology Demonstration "element proposed ground technology demonstration (GTD) testing in the early 2020's, followed by a flight technology demonstration (FTD) mission by approx. 2025. In order to reduce development costs, the demonstration projects would focus on developing a small, low thrust (approx. 7.5 -16.5 klb(f)) engine that utilizes a "common" fuel element design scalable to the higher thrust (approx. 25 klb(f)) engines used in NASA's Mars DRA 5.0 study(NASA-SP-2009-566). Besides reducing development costs and allowing utilization of existing, flight proven engine hard-ware (e.g., hydrogen pumps and nozzles), small, lower thrust ground and flight demonstration engines can validate the technology and offer improved capability -increased payloads and decreased transit times -valued for robotic science missions identified in NASA's Decadal Study.

Kinetics of element profile pattern during life cycle stage of morning-glory

International Nuclear Information System (INIS)

Nakanishi, T.M.; Tamada, M.

1999-01-01

The kinetics of seven element profiles, macroscopic elements, Na, Mg, Cl, K and Ca, as well as Al and Br, in every tissue of morning-glory (Ipomoea nil L. c.v. Murasaki), from seedling to flowering stage are presented. Barriers for the elements were formed even in the same tissue during different growing phases. Most of Na and Al remained in root tissue, showing the first barrier to the upper part of the plant. During the juvenile phase, the tissues lower than cotyledon stored the elements, especially Ca and Mg. The barrier at cotyledon did not disappear completely until seed ripening stage, except for K. Generally, late developing stem showed lower accumulation of the elements, which seemed to regulate the inflow of Mg, Ca, Cl and Br into flowering tissue. The concentrations of K, Ca, Cl and Br in leaf were kept constant in spite of twice or three times higher concentration of these elements in leaf petiole. After flowering, selective element accumulation was observed during seed development, where most of the elements were accumulated into seed wall, not in seed. Higher concentration of the elements in elder leaf, which falls into ground and will be reused as plant nutrient, might reflect the recycling system of the elements in plants. (author)

Vitamin A Affects Flatfish Development in a Thyroid Hormone Signaling and Metamorphic Stage Dependent Manner

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Ignacio Fernández

2017-06-01

Full Text Available Vitamin A (VA and retinoid derivatives are known morphogens controlling vertebrate development. Despite the research effort conducted during the last decade, the precise mechanism of how VA induces post-natal bone changes, and particularly those operating through crosstalk with the thyroid hormones (THs remain to be fully understood. Since effects and mechanisms seem to be dose and time-dependent, flatfish are an interesting study model as they undergo a characteristic process of metamorphosis driven by THs that can be followed by external appearance. Here, we studied the effects of VA imbalance that might determine Senegalese sole (Solea senegalensis skeletogenetic phenotype through development of thyroid follicles, THs homeostasis and signaling when a dietary VA excess was specifically provided during pre-, pro- or post-metamorphic stages using enriched rotifers and Artemia as carriers. The increased VA content in enriched live prey was associated to a higher VA content in fish at all developmental stages. Dietary VA content clearly affected thyroid follicle development, T3 and T4 immunoreactive staining, skeletogenesis and mineralization in a dose and time-dependent fashion. Gene expression analysis showed that VA levels modified the mRNA abundance of VA- and TH-specific nuclear receptors at specific developmental stages. Present results provide new and key knowledge to better understand how VA and TH pathways interact at tissue, cellular and nuclear level at different developmental periods in Senegalese sole, unveiling how dietary modulation might determine juvenile phenotype and physiology.

Monitoring and Analysis of Ground Settlement Induced by Tunnelling with Slurry Pressure-Balanced Tunnel Boring Machine

Directory of Open Access Journals (Sweden)

Hyunku Park

2018-01-01

Full Text Available A case study of monitoring and analysis of ground settlement caused by tunnelling of stacked twin tunnels for underground metro line construction through the densely populated area using the slurry pressure-balanced TBM is presented. Detailed ground settlement monitoring was carried out for the initial stage of down-track tunnelling in order to estimate trough width factor and volume losses including face, shield, and tail losses. In addition, using the gap model, prediction of volume loss and ground settlement was carried out with consideration of the ground condition, TBM configurations, and actual operation data. The predictions of the gap model were compared with the observed results, and adjustment factors were determined for volume loss estimation. The adjusted factors were applied to predict ground settlement of the up-track tunnel, and its results were compared with the field measurements.

Effects of food restriction across stages of juvenile and early adult development on body weight, survival and adult life history.

Science.gov (United States)

Wong, J W Y; Kölliker, M

2014-11-01

Organisms have to allocate limited resources among multiple life-history traits, which can result in physiological trade-offs, and variation in environmental conditions experienced during ontogeny can influence reproduction later in life. Food restriction may lead to an adaptive reallocation of the limited resources among traits as a phenotypically plastic adjustment, or it can act as an overall constraint with detrimental effects throughout reproductive life. In this study, we investigated experimentally the effects of food restriction during different stages of the juvenile and early adult development on body weight, survival and reproductive success in females and males of the European earwig Forficula auricularia. Individuals either received limited or unlimited access to food across three different stages of development (fully crossed) allowing us to identify sensitive periods during development and to test both additive and interactive effects of food limitation across stages on development and reproduction. Food restriction during the early and late juvenile stage had additive negative effects on juvenile survival and adult body weight. With regard to reproductive success of females which produce up to two clutches in their lifetime, restriction specifically in the late juvenile stage led to smaller first and second clutch size, lower probability of second clutch production and reduced hatching success in the second clutch. Reproductive success of females was not significantly affected when their male mates experienced food restriction during their development. Our findings in general support the 'silver-spoon' hypothesis in that food restriction during juvenile development poses constraints on development and reproduction throughout life. © 2014 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2014 European Society For Evolutionary Biology.

Monitoring of arched sched ground layer

International Nuclear Information System (INIS)

Listjak, M.; Slaninka, A.; Rau, L.; Pajersky, P.

2015-01-01

Arched Shed was a part of controlled area of NPP A1 site in Jaslovske Bohunice (Slovakia). It had been used for temporary storage of loose radioactive waste (RAW) which has been characterized within the BIDSF project C13, Characterisation of Loose Radioactive Waste'. Stored RAW has been treated and sorted within the project ',Realization of the 2 nd stage of Decommissioning Project of NPP A1'. Area of Arched Shed represents approximately 270 m 2 (45 m x 6 m). Ground layer of the AS consists mostly of soil with solid elements (stones and gravel). The aim of monitoring was to remove the contaminated soil up to 1 m below ground level. Requirement for detail monitoring of the Arched Shed ground layer resulted from conclusions of the BIDSF project C13 which has proved that massic activity 137 Cs of soil was up to few thousands Bq·kg -1 in underground layer. Dominant easy to measure radionuclide in the soil is 137 Cs which has been used as a key radionuclide for methodology of in-situ soil monitoring. Following methods has been applied during characterization: dose rate survey, sampling from defined ground layer followed by laboratory gamma spectrometry analysis by the accredited testing laboratory of radiation dosimetry VUJE (S-219) and in-situ scintillation gamma spectrometry by 1.5''x1.5'' LaBr detector. Massic activity of the remaining soil (not excavated) comply the criteria for free release into the environment (Government Regulation of Slovak Republic 345/2006 Coll.). Area was filled up by non-contaminated soil up to the ground level of surroundings. Afterward the area was covered with geotextile and concrete panels and nowadays it is ready for further usage within the NPP A1 decommissioning project as a place for treatment, conditioning and disposal of contaminated soil and concrete. (authors)

Feasibility of In-Situ Aeration of Old Dumping Ground for Land Reclamation

Directory of Open Access Journals (Sweden)

Huan-Huan Tong

2013-12-01

Full Text Available Dumping grounds are characterized by the absence of engineering controls such as base liners and cover layer. Consequently, these dumping grounds present risks for surrounding resources such as soil, groundwater and air. The concern for groundwater contamination by leachate from tropical dumping grounds is heightened due to the greater amounts of rainfall and subsequent infiltration and percolation through the waste mass. The emergent demand for old dumping grounds reclamation drives the need to employ remediation technologies. Generally, in-situ aeration is a remediation method that promotes aerobic conditions in the later stage of dumping ground. It accelerates carbon transfer, reduces remaining organic load, and generally shortens the post closure period. However, high rainfall in tropical areas straitens this technique. For example, pollutants could be easily flushed out and more energy should be required to overcome hydrostatic pressure. Although heavy rainfall could supply sufficient water to the substrate and accelerate degradation of organic matter, it may inhibit aerobic activities due to limited air transfer. The waste characterization from Lorong Halus Dumping Ground (closed dumping ground in Singapore showed that the waste materials were stabilized after 22 years closure. According to the Waste Acceptance Criteria set by European Communities Council, the waste materials could be classified as inert wastes. One interesting finding was that leachate layer detected was about of 5 - 8 meter depth, which entirely soaked the waste materials. Hence, the reclamation design and operation should be carefully adjusted according to these characters. Lorong Halus Dumping Ground case study can provide a guideline for other tropical closed landfills or dumping grounds.

Longevity of Emplacement Drift Ground Support Materials

International Nuclear Information System (INIS)

Tang, D.

2000-01-01

The purpose of this analysis is to evaluate the factors affecting the longevity of emplacement drift ground support materials and to develop a basis for selection of materials for ground support that will function throughout the preclosure period. The Development Plan (DP) for this analysis is given in CRWMS M and O (Civilian Radioactive Waste Management System Management and Operating Contractor) (1999a). The candidate materials for ground support are steel (carbon steel, ductile cast iron, galvanized steel, and stainless steel, etc.) and cement. Steel will mainly be used for steel sets, lagging, channels, rock bolts, and wire mesh. Cement usage is only considered in the case of grouted rock bolts. The candidate materials for the invert structure are steel and crushed rock ballast. The materials shall be evaluated for the repository emplacement drift environment under a specific thermal loading condition based on the proposed License Application Design Selection (LADS) design. The analysis consists of the following tasks: (1) Identify factors affecting the longevity of ground control materials for use in emplacement drifts. (2) Review existing documents concerning behavior of candidate ground control materials during the preclosure period. The major criteria to be considered for steel are mechanical and thermal properties, and durability, of which corrosion is the most important concern. (3) Evaluate the available results and develop recommendations for material(s) to be used

Neural Correlates of Auditory Figure-Ground Segregation Based on Temporal Coherence.

Science.gov (United States)

Teki, Sundeep; Barascud, Nicolas; Picard, Samuel; Payne, Christopher; Griffiths, Timothy D; Chait, Maria

2016-09-01

To make sense of natural acoustic environments, listeners must parse complex mixtures of sounds that vary in frequency, space, and time. Emerging work suggests that, in addition to the well-studied spectral cues for segregation, sensitivity to temporal coherence-the coincidence of sound elements in and across time-is also critical for the perceptual organization of acoustic scenes. Here, we examine pre-attentive, stimulus-driven neural processes underlying auditory figure-ground segregation using stimuli that capture the challenges of listening in complex scenes where segregation cannot be achieved based on spectral cues alone. Signals ("stochastic figure-ground": SFG) comprised a sequence of brief broadband chords containing random pure tone components that vary from 1 chord to another. Occasional tone repetitions across chords are perceived as "figures" popping out of a stochastic "ground." Magnetoencephalography (MEG) measurement in naïve, distracted, human subjects revealed robust evoked responses, commencing from about 150 ms after figure onset that reflect the emergence of the "figure" from the randomly varying "ground." Neural sources underlying this bottom-up driven figure-ground segregation were localized to planum temporale, and the intraparietal sulcus, demonstrating that this area, outside the "classic" auditory system, is also involved in the early stages of auditory scene analysis." © The Author 2016. Published by Oxford University Press.

Periconceptional maternal one-carbon biomarkers are associated with embryonic development according to the Carnegie stages.

Science.gov (United States)

Parisi, F; Rousian, M; Koning, A H J; Willemsen, S P; Cetin, I; Steegers-Theunissen, R P M

2017-03-01

Is periconceptional maternal one-carbon (I-C) metabolism associated with embryonic morphological development in non-malformed ongoing pregnancies? Serum vitamin B12, red blood cell (RBC) folate and plasma total homocysteine (tHcy) are associated with embryonic development according to the Carnegie stages. Derangements in maternal I-C metabolism affect reproductive and pregnancy outcomes, as well as future health of the offspring. Between 2010 and 2014, women with singleton ongoing pregnancies were enrolled in a prospective periconceptional cohort study. A total of 234 pregnancies, including 138 spontaneous or IUI pregnancies with strict pregnancy dating and 96 pregnancies derived from IVF, ICSI or cryopreserved embryo transfer (IVF/ICSI pregnancies), underwent longitudinal transvaginal three-dimensional ultrasound (3D US) scans from 6+0 up to 10+2 weeks of gestation. Carnegie stages were defined using internal and external morphologic criteria in a virtual reality system. Maternal venous blood samples were collected at enrollment for serum vitamin B12, RBC folate and plasma tHcy assessment. Associations between biomarker concentrations and longitudinal Carnegie stages were investigated using linear mixed models. We performed a median of three 3D US scans per pregnancy (range 1-5) resulting in 600 good quality data sets for the Carnegie stage annotation (80.5%). Vitamin B12 was positively associated with embryonic development in the total study population (β = 0.001 (95% CI: 0.000; 0.002), P Carnegie stages only in IVF/ICSI pregnancies (β = 0.001 (95% CI: 0.0005; 0.0015), P < 0.05). In this group, low RBC folate concentrations (-2SD, 875.4 nmol/l) were associated with a 1.8-day delay (95% CI: 1.7-1.8) in development compared with high concentrations (+2SD, 2119.9 nmol/l). tHcy was negatively associated with embryonic development in the total study population (β = -0.08 (95% CI: -0.14; -0.02), P < 0.01), as well as in the IVF/ICSI subgroup (β = -0.08 (95% CI: -0

Intentionality: evolutionary development in healing: a grounded theory study for holistic nursing.

Science.gov (United States)

Zahourek, Rothlyn P

2005-03-01

Although intentionality has been implicated as a causal variable in healing research, its definition has been inconsistent and vague. The objective of this grounded theory study is to develop a substantive theory of intentionality in a naturalistic encounter between nurse-healers and their healee-clients, and to consider the implications for practice and research. Six expert nurse-healers and six healee-clients were interviewed as individuals and in dyads before and after treatments. Interviews and observational data were analyzed using the constant comparative method and synthesized analysis. Participants described their experience of intentionality in healing as an evolutionary process characterized by distinctive shifts. The theory of intentionality: the matrix for healing (IMH) includes definitions of intentionality and a conceptual framework of three developmental phases of intentionality (generic, healing, and transforming intentionalities). The predominant attribute, development, is described. The theory contributes to knowledge about healing and intentionality and has implications for practice and future research.

Dynamic Modeling of Starting Aerodynamics and Stage Matching in an Axi-Centrifugal Compressor

Science.gov (United States)

Wilkes, Kevin; OBrien, Walter F.; Owen, A. Karl

1996-01-01

A DYNamic Turbine Engine Compressor Code (DYNTECC) has been modified to model speed transients from 0-100% of compressor design speed. The impetus for this enhancement was to investigate stage matching and stalling behavior during a start sequence as compared to rotating stall events above ground idle. The model can simulate speed and throttle excursions simultaneously as well as time varying bleed flow schedules. Results of a start simulation are presented and compared to experimental data obtained from an axi-centrifugal turboshaft engine and companion compressor rig. Stage by stage comparisons reveal the front stages to be operating in or near rotating stall through most of the start sequence. The model matches the starting operating line quite well in the forward stages with deviations appearing in the rearward stages near the start bleed. Overall, the performance of the model is very promising and adds significantly to the dynamic simulation capabilities of DYNTECC.

Evaluating Potential of MODIS-based Indices in Determining “Snow Gone” Stage over Forest-dominant Regions

Directory of Open Access Journals (Sweden)

Navdeep S. Sekhon

2010-05-01

Full Text Available “Snow gone” (SGN stage is one of the critical variables that describe the start of the official forest fire season in the Canadian Province of Alberta. In this paper, our objective is to evaluate the potential of MODIS-based indices for determining the SGN stage. Those included: (i enhanced vegetation index (EVI, (ii normalized difference water index (NDWI using the shortwave infrared (SWIR spectral bands centered at 1.64 µm (NDWI1.64µm and at 2.13 µm (NDWI2.13µm, and (iii normalized difference snow index (NDSI. These were calculated using the 500 m 8-day gridded MODIS-based composites of surface reflectance data (i.e., MOD09A1 v.005 for the period 2006–08. We performed a qualitative evaluation of these indices over two forest fire prone natural subregions in Alberta (i.e., central mixedwood and lower boreal highlands. In the process, we generated and compared the natural subregion-specific lookout tower sites average: (i temporal trends for each of the indices, and (ii SGN stage using the ground-based observations available from Alberta Sustainable Resource Development. The EVI-values were found to have large uncertainty at the onset of the spring and unable to predict the SGN stages precisely. In terms of NDSI, it showed earlier prediction capabilities. On the contrary, both of the NDWI’s showed distinct pattern (i.e., reached a minimum value before started to increase again during the spring in relation to observed SGN stages. Thus further analysis was carried out to determine the best predictor by comparing the NDWI’s predicted SGN stages with the ground-based observations at all of the individual lookout tower sites (approximately 120 in total across the study area. It revealed that NDWI2.13µm demonstrated better prediction capabilities (i.e., on an average approximately 90% of the observations fell within ±2 periods or ±16 days of deviation in comparison to NDWI1.64µm (i.e., on an average approximately 73% of the

Predictive Coding Accelerates Word Recognition and Learning in the Early Stages of Language Development

Science.gov (United States)

Ylinen, Sari; Bosseler, Alexis; Junttila, Katja; Huotilainen, Minna

2017-01-01

The ability to predict future events in the environment and learn from them is a fundamental component of adaptive behavior across species. Here we propose that inferring predictions facilitates speech processing and word learning in the early stages of language development. Twelve- and 24-month olds' electrophysiological brain responses to heard…

Stage specific effects of soluble copper and copper oxide nanoparticles during sea urchin embryo development and their relation to intracellular copper uptake.

Science.gov (United States)

Torres-Duarte, Cristina; Ramos-Torres, Karla M; Rahimoff, René; Cherr, Gary N

2017-08-01

The effects of exposure to either soluble copper (copper sulfate) or copper oxide nanoparticles (nano-CuO) during specific early developmental stages of sea urchin embryos were analyzed. Soluble copper caused significant malformations in embryos (skeletal malformations, delayed development or gut malformations) when present at any given stage, while cleavage stage was the most sensitive to nano-CuO exposure causing skeletal malformations and decreased total antioxidant capacity. The stage specificity was linked to higher endocytic activity during the first hours of development that leads to higher accumulation of copper in specific cells critical for development. Results indicate that nano-CuO results in higher accumulation of copper inside of embryos and this intracellular copper is more persistent as compared to soluble copper. The possible implications later in development are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

Development of a Ground Test Concept Based on Multi-Rotors for In-Flight RVD Experimentation

Science.gov (United States)

2015-08-01

Linux Real-Time work station • Ad-Hoc WiFi internal network for data streaming • High pressure air compressor and compressed air filling station. 12... Air Force Research Laboratory Air Force Office of Scientific Research European Office of Aerospace Research and Development Unit 4515, APO...of screws and nuts, • the same rod is connected to a structure with a base on ground. 6 Distribution A: Approved for public release; distribution is

Second status report on regional ground-water flow modeling for the Palo Duro Basin, Texas

International Nuclear Information System (INIS)

1986-07-01

Regional ground-water flow within the principal geohydrologic units of the Palo Duro Basin is evaluated by developing a conceptual model of the flow regime and testing the model using a three-dimensional, finite-difference flow code. Sensitivity analyses (a limited parametric study) are conducted to define the system responses to changes in the conceptual model. Of particular interest are the impacts of salt permeability and potential climatic changes on the system response. The conceptual model is described in terms of its areal and vertical discretization, aquifer properties, fluid properties and hydrologic boundary conditions. The simulated ground-water flow fields are described with potentiometric surfaces, tables summarizing the areal and vertical volumetric flows through the principal units, and Darcy velocities within specified finite-difference blocks. The reported work is the second stage of an ongoing evaluation of the Palo Duro Basin as a potential repository for high-level radioactive wastes. The results and conclusions should thus be considered preliminary and subject to modification with the collection of additional data. However, the report does provide a useful basis for describing the sensitivity of the present conceptualization of ground-water flow to particular parameters and, to a lesser extent, the uncertainties in the present conceptualization. 28 refs., 44 figs., 13 tabs

Grounding Anger Management

Directory of Open Access Journals (Sweden)

Odis E. Simmons, PhD

2017-06-01

Full Text Available One of the things that drew me to grounded theory from the beginning was Glaser and Strauss’ assertion in The Discovery of Grounded Theory that it was useful as a “theoretical foothold” for practical applications (p. 268. From this, when I was a Ph.D student studying under Glaser and Strauss in the early 1970s, I devised a GT based approach to action I later came to call “grounded action.” In this short paper I’ll present a very brief sketch of an anger management program I developed in 1992, using grounded action. I began my research by attending a two-day anger management training workshop designed for training professionals in the most commonly used anger management model. Like other intervention programs I had seen, this model took a psychologizing and pathologizing approach to the issue. Following this, I sat through the full course of an anger management program that used this model, observing the reactions of the participants and the approach of the facilitator. Following each session I conducted open-ended interviews with most of the participants, either individually or in groups of two or three. I had also done previous research in counseling and social work contexts that turned out to be very relevant to an anger management program design.

A Ground-Nesting Galliform's Response to Thermal Heterogeneity: Implications for Ground-Dwelling Birds.

Science.gov (United States)

Carroll, J Matthew; Davis, Craig A; Elmore, R Dwayne; Fuhlendorf, Samuel D

2015-01-01

The habitat selection choices that individuals make in response to thermal environments influence both survival and reproduction. Importantly, the way that organisms behaviorally respond to thermal environments depends on the availability and juxtaposition of sites affording tolerable or preferred microclimates. Although, ground nesting birds are especially susceptible to heat extremes across many reproductive stages (i.e., breeding, nesting, brood rearing), the mechanistic drivers of nest site selection for these species are not well established from a thermal perspective. Our goal was to assess nest site selection relative to the configuration of the thermal landscape by quantifying thermal environments available to a ground-nesting bird species inhabiting a climatically stressful environment. Using northern bobwhite (Colinus virginanus) as a model species, we measured black bulb temperature (Tbb) and vegetation parameters at 87 nests, 87 paired sites and 205 random landscape sites in Western Oklahoma during spring and summer 2013 and 2014. We found that thermal space within the study area exhibited differences in Tbb of up to 40°C during peak diurnal heating, resulting in a diverse thermal landscape available to ground-nesting birds. Within this thermally heterogeneous landscape, nest sites moderated Tbb by more than 12°C compared to random landscape sites. Furthermore, successful nests remained on average 6°C cooler than unsuccessful nests on days experiencing ambient temperatures ≥ 39°C. Models of future Tbb associated with 2080 climate change projections indicate that nesting bobwhites will face substantially greater Tbb throughout the landscape for longer durations, placing an even greater importance on thermal choices for nest sites in the future. These results highlight the capacity of landscape features to act as moderators of thermal extremes and demonstrate how thermal complexity at organism-specific scales can dictate habitat selection.

Design and development of an automated D.C. ground fault detection and location system for Cirus

International Nuclear Information System (INIS)

Marik, S.K.; Ramesh, N.; Jain, J.K.; Srivastava, A.P.

2002-01-01

Full text: The original design of Cirus safety system provided for automatic detection of ground fault in class I D.C. power supply system and its annunciation followed by delayed reactor trip. Identification of a faulty section was required to be done manually by switching off various sections one at a time thus requiring a lot of shutdown time to identify the faulty section. Since class I power supply is provided for safety control system, quick detection and location of ground faults in this supply is necessary as these faults have potential to bypass safety interlocks and hence the need for a new system for automatic location of a faulty section. Since such systems are not readily available in the market, in-house efforts were made to design and develop a plant-specific system, which has been installed and commissioned

Simulated Effects of Ground-Water Augmentation on the Hydrology of Round and Halfmoon Lakes in Northwestern Hillsborough County, Florida

Science.gov (United States)

Yager, Richard M.; Metz, P.A.

2004-01-01

Pumpage from the Upper Floridan aquifer in northwest Hillsborough County near Tampa, Florida, has induced downward leakage from the overlying surficial aquifer and lowered the water table in many areas. Leakage is highest where the confining layer separating the aquifers is breached, which is common beneath many of the lakes in the study area. Leakage of water to the Upper Floridan aquifer has lowered the water level in many lakes and drained many wetlands. Ground water from the Upper Floridan aquifer has been added (augmented) to some lakes in an effort to maintain lake levels, but the resulting lake-water chemistry and lake leakage patterns are substantially different from those of natural lakes. Changes in lake-water chemistry can cause changes in lake flora, fauna, and lake sediment composition, and large volumes of lake leakage are suspected to enhance the formation of sinkholes near the shoreline of augmented lakes. The leakage rate of lake water through the surficial aquifer to the Upper Floridan aquifer was estimated in this study using ground-water-flow models developed for an augmented lake (Round Lake) and non-augmented lake (Halfmoon Lake). Flow models developed with MODFLOW were calibrated through nonlinear regression with UCODE to measured water levels and monthly net ground-water-flow rates from the lakes estimated from lake-water budgets. Monthly estimates of ground-water recharge were computed using an unsaturated flow model (LEACHM) that simulated daily changes in storage of water in the soil profile, thus estimating recharge as drainage to the water table. Aquifer properties in the Round Lake model were estimated through transient-state simulations using two sets of monthly recharge rates computed during July 1996 to February 1999, which spanned both average conditions (July 1996 through October 1997), and an El Ni?o event (November 1997 through September 1998) when the recharge rate doubled. Aquifer properties in the Halfmoon Lake model were

Dynasting Theory: Lessons in learning grounded theory

Directory of Open Access Journals (Sweden)

Johnben Teik-Cheok Loy, MBA, MTS, Ph.D.

2011-06-01

Full Text Available This article captures the key learning lessons gleaned from the author’s experience learning and developing a grounded theory for his doctoral dissertation using the classic methodology as conceived by Barney Glaser. The theory was developed through data gathered on founders and successors of Malaysian Chinese family-own businesses. The main concern for Malaysian Chinese family businesses emerged as dynasting . the building, maintaining, and growing the power and resources of the business within the family lineage. The core category emerged as dynasting across cultures, where founders and successors struggle to transition from traditional Chinese to hybrid cultural and modernized forms of family business from one generation to the next. The key learning lessons were categorized under five headings: (a sorting through different versions of grounded theory, (b educating and managing research stakeholders, (c embracing experiential learning, (d discovering the core category: grounded intuition, and (e recognizing limitations and possibilities.Keywords: grounded theory, learning, dynasting, family business, Chinese

H-Bridge Transformerless Inverter with Common Ground for Single-Phase Solar-Photovoltaic System

DEFF Research Database (Denmark)

Siwakoti, Yam Prasad; Blaabjerg, Frede

2017-01-01

This paper proposes a new single-phase H-Bridge transformerless inverter with common ground for grid-connected photovoltaic systems (hereafter it is called ‘Siwakoti-H’ inverter). The inverter works on the principle of flying capacitor and consists of only four power switches (two reverse blocking...... IGBT's (RB-IGBT) and two MOSFET's), a capacitor and a small filter at the output stage. The proposed topology share a common ground with the grid and the PV source. A Unipolar Sinusoidal Pulse-Width Modulation (SPWM) technique is used to modulate the inverter to minimize switching loss, output current...

Evaluating Managerial Styles for System Development Life Cycle Stages to Ensure Software Project Success

Science.gov (United States)

Kocherla, Showry

2012-01-01

Information technology (IT) projects are considered successful if they are completed on time, within budget, and within scope. Even though, the required tools and methodologies are in place, IT projects continue to fail at a higher rate. Current literature lacks explanation for success within the stages of system development life-cycle (SDLC) such…

Grounded theory.

Science.gov (United States)

Harris, Tina

2015-04-29

Grounded theory is a popular research approach in health care and the social sciences. This article provides a description of grounded theory methodology and its key components, using examples from published studies to demonstrate practical application. It aims to demystify grounded theory for novice nurse researchers, by explaining what it is, when to use it, why they would want to use it and how to use it. It should enable nurse researchers to decide if grounded theory is an appropriate approach for their research, and to determine the quality of any grounded theory research they read.

CT characteristics and pathological implications of early stage (T1N0M0) lung adenocarcinoma with pure ground-glass opacity

Energy Technology Data Exchange (ETDEWEB)

Jin, Xin; Zhao, Shao-hong; Wu, Jian; Wu, Chong-chong; Chang, Rui-ping; Ju, Hai-yue [Chinese PLA General Hospital, Department of Radiology, Beijing (China); Gao, Jie; Wang, Dian-jun [Chinese PLA General Hospital, Department of Pathology, Beijing (China)

2015-09-15

To analyze the CT characteristics and pathological classification of early lung adenocarcinoma (T1N0M0) with pure ground-glass opacity (pGGO). Ninety-four lesions with pGGO on CT in 88 patients with T1N0M0 lung adenocarcinoma were selected from January 2010 to December 2012. All lesions were confirmed by pathology. CT appearances were analyzed including lesion location, size, density, uniformity, shape, margin, tumour-lung interface, internal and surrounding malignant signs. Lesion size and density were compared using analysis of variance, lesion size also assessed using ROC curves. Gender of patients, lesion location and CT appearances were compared using χ2-test. There were no significant differences in gender, lesion location and density with histological invasiveness (P > 0.05). The ROC curve showed that the possibility of invasive lesion was 88.73 % when diameter of lesion was more than 10.5 mm. There was a significant difference between lesion uniformity and histological invasiveness (P = 0.01). There were significant differences in margin, tumour-lung interface, air bronchogram with histological invasiveness (P = 0.02,P = 0.00,P = 0.048). The correlation index of lesion size and uniformity was r = 0.45 (P = 0.00). The lesion size and uniformity, tumour-lung interface and the air bronchogram can help predict invasive extent of early stage lung adenocarcinoma with pGGO. (orig.)

Ground cross-modal impedance as a tool for analyzing ground/plate interaction and ground wave propagation.

Science.gov (United States)

Grau, L; Laulagnet, B

2015-05-01

An analytical approach is investigated to model ground-plate interaction based on modal decomposition and the two-dimensional Fourier transform. A finite rectangular plate subjected to flexural vibration is coupled with the ground and modeled with the Kirchhoff hypothesis. A Navier equation represents the stratified ground, assumed infinite in the x- and y-directions and free at the top surface. To obtain an analytical solution, modal decomposition is applied to the structure and a Fourier Transform is applied to the ground. The result is a new tool for analyzing ground-plate interaction to resolve this problem: ground cross-modal impedance. It allows quantifying the added-stiffness, added-mass, and added-damping from the ground to the structure. Similarity with the parallel acoustic problem is highlighted. A comparison between the theory and the experiment shows good matching. Finally, specific cases are investigated, notably the influence of layer depth on plate vibration.

Simulation of the Regional Ground-Water-Flow System and Ground-Water/Surface-Water Interaction in the Rock River Basin, Wisconsin

Science.gov (United States)

Juckem, Paul F.

2009-01-01

A regional, two-dimensional, areal ground-water-flow model was developed to simulate the ground-water-flow system and ground-water/surface-water interaction in the Rock River Basin. The model was developed by the U.S. Geological Survey (USGS), in cooperation with the Rock River Coalition. The objectives of the regional model were to improve understanding of the ground-water-flow system and to develop a tool suitable for evaluating the effects of potential regional water-management programs. The computer code GFLOW was used because of the ease with which the model can simulate ground-water/surface-water interactions, provide a framework for simulating regional ground-water-flow systems, and be refined in a stepwise fashion to incorporate new data and simulate ground-water-flow patterns at multiple scales. The ground-water-flow model described in this report simulates the major hydrogeologic features of the modeled area, including bedrock and surficial aquifers, ground-water/surface-water interactions, and ground-water withdrawals from high-capacity wells. The steady-state model treats the ground-water-flow system as a single layer with hydraulic conductivity and base elevation zones that reflect the distribution of lithologic groups above the Precambrian bedrock and a regionally significant confining unit, the Maquoketa Formation. In the eastern part of the Basin where the shale-rich Maquoketa Formation is present, deep ground-water flow in the sandstone aquifer below the Maquoketa Formation was not simulated directly, but flow into this aquifer was incorporated into the GFLOW model from previous work in southeastern Wisconsin. Recharge was constrained primarily by stream base-flow estimates and was applied uniformly within zones guided by regional infiltration estimates for soils. The model includes average ground-water withdrawals from 1997 to 2006 for municipal wells and from 1997 to 2005 for high-capacity irrigation, industrial, and commercial wells. In addition

Electromagnetic simulators for Ground Penetrating Radar applications developed in COST Action TU1208

Science.gov (United States)

Pajewski, Lara; Giannopoulos, Antonios; Warren, Craig; Antonijevic, Sinisa; Doric, Vicko; Poljak, Dragan

2017-04-01