WorldWideScience

Sample records for gro newsletter issue

  1. EQUIP3 Newsletter. Issue Number 19

    Science.gov (United States)

    EQUIP3, 2009

    2009-01-01

    The "EQUIP3 Newsletter" is an e-newsletter that is currently sent to subscribers quarterly. It provides updates on EQUIP3 activities and initiatives, and shares excerpts from relevant youth development resources. This issue contains the following articles: (1) Bangladesh Youth Employment Pilot (BYEP); (2) CSY [Cross-Sectoral Youth]/YED…

  2. Science Information Systems Newsletter, issue 28

    Science.gov (United States)

    1993-01-01

    The purpose of the Information Systems Newsletter is to inform the space science and applications research community about information systems development and to promote coordination and collaboration by providing a forum for communication. This quarterly publication focuses on programs sponsored by the Information Systems Branch in support of NASA's Office of Space Science. Articles of interest for other programs and agencies are presented as well. The April 1993 issue is presented.

  3. BE Newsletter Issue #17 December 2016

    CERN Document Server

    Billen, Ronny

    2016-01-01

    Inside this issue: Editorial – Ronny Billen My Work Experience at CERN as a Student Trainee – Gerda Powell, Summer Trainee 2015 BE-BI Communication and Informatics for Controls – Fernando Varela, BE-ICS Controls Configuration Service – a challenge in usability – Lukasz Burdzanowski, BE-CO Pushing LEIR limits to new horizons – Giulia Bellodi, Alexander Huschauer BE-ABP Colonne Sécurité Administration & Human Resources Responsibility Changes Newsletter contacts

  4. BE Newsletter Issue #14 August 2015

    CERN Document Server

    Billen, Ronny

    2015-01-01

    Inside this issue: Editorial – Ronny Billen SPS and LHC scrubbing: A way through the clouds – Giovanni Rumolo, Giovanni Iadarola, Kevin Li, Annalisa Romano, Michael Schenk, BE-ABP-HSC, Hannes Bartosik, Lotta Mether, BE-ABP-LAT TrimMachine – a concept application – Valter Correia Costa, BE-RF-CS, Bertrand Lefort, BE-OP-AD Accelerator Performance: Statistics & Fault Tracking – Chris Roderick, BE-CO-DS Safety Column – Mesure à prendre en cas de forte chaleur ? – Safety Unit Life in BE - Beam-beam compensation for undergraduates – Ray Veness, BE-BI-ML Newsletter contacts

  5. BE Newsletter Issue #11 September 2014

    CERN Document Server

    Billen, Ronny

    2014-01-01

    Inside this issue: Editorial – Ronny Billen Simulating beam cleaning in the LHC – Roderik Bruce, BE-ABP-HSS The CERN Resonant WISP Search – Michael Betz, BE-BI-QP The LHC sees the light at the end of the tunnel – Matteo Solfaroli Camillocci, Mirko Pojer, BE-OP-LHC New Magnetic Alloy Based RF Cavities for Synchrotrons – Mauro Paoluzzi, BE-RF-IS Safety column – Prevention against oxygen deficiency hazard (ODH) in the LHC – Safety Unit Responsibility changes & Newsletter contacts

  6. BE Newsletter Issue #12 December 2014

    CERN Document Server

    Billen, Ronny

    2014-01-01

    Inside this issue: Editorial – Ronny Billen Playing XBOX@CTF3 – Jose Luis Navarro Quirante & Frank Tecker, BE-OP-PS/CTF3 Independence for Controls – Stefan Lüders, IT-DI-CSO The Smooth Upgrades Working Group – Vito Baggiolini, BE-CO, Leader of the SUWG A Cryogenic Beam Current Monitor for Low-Energy Antiproton Facilities – Miguel Abreu Fernandes, BE-BI-PI Les EIS : Vous connaissez ? – Anne Funken, BE-ASR-SU Safety Column – Safety Unit Life in BE – Juan F. Esteban Müller, BE-RF-BR Responsibility changes & Newsletter contacts

  7. BE Newsletter Issue #13 April 2015

    CERN Document Server

    Billen, Ronny

    2015-01-01

    Inside this issue: Editorial – Ronny Billen Extra Low Energy Antiproton ring ELENA – Christian Carli, BE-ABP-HSC, on behalf of the ELENA and AD teams LEIR: When, Why, What? – Django Manglunki, BE-OP-SPS for the LEIR team LHC LLRF restart – Helga Timko, BE-RF-FB From instrumentation to education with a pixel detector – Oliver Keller, DG-EDU (formerly BE-BI-BL) Les coulisses d’un exercice d’évacuation – Annie Di Luca, Christelle Gaignant, BE-ASR-SU Safety Column – Simplification des cours de sécurité “e-learning” – Safety Unit Responsibility changes & Newsletter contacts

  8. BE Newsletter Issue #15 December 2015

    CERN Document Server

    Billen, Ronny

    2015-01-01

    Inside this issue: Editorial – Ronny Billen The PS to SPS Multi-Turn Extraction (MTE): ready for 2016! – Simone Gilardoni, Massimo Giovannozzi, Cedric Hernalsteens, Alexander Huschauer and Guido Sterbini on behalf of the BE-ABP team, – PSB-OP, PS-OP, and SPS-OP teams Gis Portal Racks – Olivier Barrière, BE-CO-IN Electron Cooling at CERN – Gérard Tranquille, BE-BI-EA BE-OP-TI logbook remodelling – Daniel Martin Anido, BE-OP-TI – Emanuele Matli, BE-OP-PSB A new seminar to BE – Get to know some of our brilliant young minds – Eva Barbara Holzer, BE-BI-BL BlonD(e) – Simon Albright, Theodoros Argyropoulos, Juan Esteban Müller, Alexandre Lasheen, Danilo Quartullo, Elena Shaposhnikova & Helga Timko, BE-RF, With special thanks to Danilo Piparo, PH-SFT and Alberto Pace, IT-DSS Safety Column – Ma liste de contrôle avant l’hiver – Safety Unit Responsibility changes & Special Award Newsletter contacts

  9. BE Newsletter Issue #5 September 2012

    CERN Document Server

    Billen, Ronny

    2012-01-01

    Inside this issue: Editorial – R. Billen Lindau meeting – Giulia Papotti – BE-OP-LHC, Roderik Bruce – BE-ABP- LCU Knowledge transfer in the BE Department – a discussion – Fritz Caspers, BE-RF-BR Cherenkov Fibers as a Beam Loss Monitor for CLIC – Sophie Mallows, BE-BI-BL Putting the Hadrons in the LHC – R. Scrivens, BE-ABP-HSL Life in BE – G. Kautzman, BE-ABP-SU Safety Column – BE Safety Unit Safety issues for LS1 – Special issue, BE Safety Unit Responsibility Changes and Special Awards – ASR-AS

  10. BE Newsletter Issue #10 April 2014

    CERN Document Server

    Billen, Ronny

    2014-01-01

    Inside this issue: Editorial – Ronny Billen Laser-based Transverse Emittance Measurement for LINAC4 – T. Hofmann, BE-BI-PM New SPS energy saving scheme – S. Cettour Cave, V. Kain, BE-OP-SPS, C. Kittel, BE-OP-PS, J.-C. Bau, BE-CO-HT, S. Page, BE-CO-DO Bio-LEIR A “healthy” future ahead – A. Garonna, (ex ABP-HSC), PH-UGC – D. Abler, Oxford University & IT-SDC Latest safety alerts – Safety Unit Safety column – Something new in the PS complex – Safety Unit

  11. BE Newsletter Issue #9 December 2013

    CERN Document Server

    Billen, Ronny

    2013-01-01

    Inside this issue: Editorial – Ronny Billen Linac4 type position measurement and more... – J. Tan, BE-BI-PI, M. Ludwig, BE-BI-SW Time for JUAS 2014 – Guido Sterbini, BE-ABP-LIS Inspector, a rapid application development framework with embedded telemetry and alarm capabilities for hardware specialiste and machine operators – Bertrand Lefort, BE-OP-AD, Martino Giordano Ferrari, BE-OP-PSB Raspberry Pi, unesolution rapide, économique et compacte – Eric Veyrunes, BE-OP-SPS LifeinBE – Ester Sancho Cabrera, BE-RF-PM Latest safety alerts – Safety Unit Safety column – Safety Unit

  12. BE Newsletter Issue #3 December 2011

    CERN Document Server

    Billen, Ronny

    2011-01-01

    Inside this issue: Editorial – R. Billen OPERA : The experiment, which will change the world ? –J. Serrano, BE-CO-HT Determination of the distance to Gran Sasso – M. Jones, BE-ABP-SU J’aime les GEM – J. Spanggaard , BE-BI ELENA, A new challenge for the RF Group – M. E. Angoletta, BE-RF Safety Column – BE Safety Unit Parc automobile, autopartage, gaz naturel.. Que faut-il retenir sur les voitures du CERN? – A. Di Luca – C. Thomas, BE-ASR Life in BE – H. Bartosik, BE-ABP-LIS

  13. BE Newsletter Issue #1 May 2011

    CERN Document Server

    Billen, Ronny

    2011-01-01

    Inside this issue: Editorial – Paul Collier, BE Department Head Un nouvel outil de sécurité : le « Beam Permit » – Marc Tavlet on behalf of ASR-SU Characterizing the LHC Beams’ Transverse and Longitudinal Distributions with Synchrotron Radiation Monitors – Federico Roncarolo on behalf of BI-PM La micro-triangulation, l’optimisation d’un instrument traditionnel – Sylvain Griffet on behalf of ABP-SU OP-TI in a Nutshell – Eric Lienard on behalf of OP-TI LHC Transverse Damper from Commissioning to Routine – Wolfgang Hofle on behalf of RF-FB Safety Column – Magali Gruwé on behalf of ASR-SU BTE Desktop – Pierre Charrue, CO-IN Life in BE – Zereyakob Makonnen, CO-DM

  14. BE Newsletter Issue #8 September 2013

    CERN Document Server

    Billen, Ronny

    2013-01-01

    Inside this issue: Editorial – Ronny Billen Cryogenic Beam Loss Monitors (CryoBLM) for the LHC –Marcin Bartosik, Bernd Dehning, Barbara Holzer, Christoph Kurfuerst and Mariusz Sapinski, BE-BI-BL LHC Magnet Splice Quality Control – Jean-Charles Dumont, BE-OP-PS, Guy Crockford, BE-OP-LHC Virtual PC: The standard BE/CO tool for developers of controls applications – Luigi Gallerani, BE-CO-IN Reshaping of Injector alignment – Patrick Bestmann, Tobias Dobers, D. Missiaen, BE-ABP-SU Linac4: Premiers faisceaux à 3 MeV – J.-B. Lallement, BE-ABP-HSL Latest safety alerts – SafetyUnit Life in BE – Tom Levens, BE-RF-FB

  15. BE Newsletter Issue #7 April 2013

    CERN Document Server

    Billen, Ronny

    2013-01-01

    Inside this issue: Editorial – Ronny Billen New Isolde Synoptic project – Martino Giordano Ferrari, BE-OP-PSB, Emiliano Piselli, BE-BI-BL Nivellement rapide dans le LHC – Jean-Frédéric Fuchs, BE-ABP-SU, Dominique Missiaen, BE-ABP-SU The Software Improvement Process– Tools and Rules to Encourage Quality –Katarina Sigerud, BE-CO-DA, Vito Baggiolini, BE-CO-DO Emitance Mètre pour le Linac4 à partir de 3 MeV – Delphine Gérard, BE-BI-ML Superconducting RF and Infrastructure Upgrading at CERN – Karl Schirm, BE-RF-SRF Identification des risques à mon poste de travail – Analyse de risques – BE Safety Unit Stress and back pains: who can escape? Safety column – Safety Unit Prevessin site – Pedestrian and cycle entrance Life in BE

  16. New England Wind Forum: A Wind Powering America Project, Volume 1, Issue 3 -- October 2007 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, R. C.; Gifford, J.

    2007-10-01

    The New England Wind Forum electronic newsletter summarizes the latest news in wind energy development activity, markets, education, and policy in the New England region. It also features an interview with a key figure influencing New England's wind energy development. Volume 1, Issue 3 features an interview with Andrew Dzykewicz, Commissioner of the Rhode Island Office of Energy Resources.

  17. New England Wind Forum: A Wind Powering America Project, Volume 1, Issue 4 -- May 2008 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, R. C.; Gifford, J.

    2008-05-01

    The New England Wind Forum electronic newsletter summarizes the latest news in wind energy development activity, markets, education, and policy in the New England region. It also features an interview with a key figure influencing New England's wind energy development. Volume 1, Issue 4 features an interview with Brian Fairbank, president and CEO of Jiminy Peak Mountain Resort.

  18. Urban Issues. National Dropout Prevention Center/Network Newsletter. Volume 20, Number 4

    Science.gov (United States)

    Duckenfield, Marty, Ed.

    2008-01-01

    The "National Dropout Prevention Newsletter" is published quarterly by the National Dropout Prevention Center/Network. This issue contains the following articles: (1) Education in the Urban Context (Ed Lambert); (2) An Interview with Paul Reville, Massachusetts Secretary of Education; (3) Communities In Schools of Chicago (Jane…

  19. CCA Newsletters

    Science.gov (United States)

    ... meck's match play - horseheads, NY brings wonder to students - all the way for cca - craniofacial acceptance month CCA 2014 Issue 1 Newsletter - message from the executive director - chocolate festival - friends of jeremy - lily's dinner - pete's oktoberfest - ...

  20. EDIN-USVI Clean Energy Quarterly: Volume 1, Issue 3, September 2011 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2011-09-01

    This quarterly newsletter provides timely news and information about the plans and progress of the Energy Development in Island Nations-U.S. Virgin Islands pilot project, including significant events and milestones, work undertaken by each of the five working groups, and project-related renewable energy and energy efficiency educational outreach and technology deployment efforts.

  1. EDIN-USVI Clean Energy Quarterly: Volume 2, Issue 1, June 2012 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2012-06-01

    This quarterly newsletter provides timely news and information about the plans and progress of the Energy Development in Island Nations-U.S. Virgin Islands pilot project, including significant events and milestones, work undertaken by each of the working groups, and project-related technology deployment efforts.

  2. IDRA Newsletter, 2001.

    Science.gov (United States)

    Montecel, Maria Robledo , Ed.; Goodman, Christie L., Ed.

    2001-01-01

    The 10 issues of IDRA Newsletter published in 2001 focus on education in Texas and on national and statewide educational issues concerning minority, low-income, or bilingual students. Feature articles are: "Challenges and Strategies for Principals of Low-Performing Schools" (Abelardo Villarreal); "Coca-Cola Valued Youth Program in…

  3. Adolescence Education Newsletter, 2001.

    Science.gov (United States)

    Villanueva, Carmelita L., Ed.; Espada-Carlos, Lichelle Dara, Ed.

    2001-01-01

    This document comprises the two 2001 issues of a UNESCO newsletter addressing topics related to adolescent well-being in the Asia-Pacific region, particularly reproductive and sexual health. Each issue contains news from the region on various initiatives related to adolescent health and education, as well as Web links and publications on the…

  4. Adolescence Education Newsletter, 1999.

    Science.gov (United States)

    Villanueva, Carmelita L., Ed.; Padilla, Teresita M., Ed.

    1999-01-01

    This document comprises the two 1999 issues of a UNESCO newsletter addressing topics related to adolescent well-being in the Asia-Pacific region, particularly reproductive and sexual health. Each issue contains news from the region on various initiatives related to adolescent heath and education, as well as Web links and publications on the…

  5. Adolescence Education Newsletter, 1998.

    Science.gov (United States)

    Villanueva, Carmelita L., Ed.; Padilla, Teresita M., Ed.

    1998-01-01

    This document comprises two issues of a new UNESCO newsletter addressing topics related to adolescent well-being in the Asia-Pacific region, particularly reproductive and sexual health. Both issues contain news from the region on various initiatives related to adolescent health and education, as well as Web links and publications on the subject.…

  6. Adolescence Education Newsletter, 2000.

    Science.gov (United States)

    Villanueva, Carmelita L., Ed.; Padilla, Teresita M., Ed.

    2000-01-01

    This document comprises the two 2000 issues of a UNESCO newsletter addressing topics related to adolescent well-being in the Asia-Pacific region, particularly reproductive and sexual health. Each issue contains news from the region on various initiatives related to adolescent health and education, as well as Web links and publications on the…

  7. Adolescence Education Newsletter, 2002.

    Science.gov (United States)

    Villanueva, Carmelita L., Ed.; Espada-Carlos, Lichelle Dara, Ed.

    2002-01-01

    This document consists of the two 2002 issues of a UNESCO newsletter addressing topics related to adolescent well-being in the Asia-Pacific region, particularly reproductive and sexual health. Each issue includes news from the region on various initiatives related to adolescent health and education, as well as Web links and publications on the…

  8. IWGIA Newsletter: 1993 = IWGIA Boletin: 1993.

    Science.gov (United States)

    IWGIA Newsletter, 1993

    1993-01-01

    This document contains the four 1992 English-language issues of the IWGIA newsletter and the four corresponding issues in Spanish. These newsletters provide educators with a resource on the history, current conditions, and struggles for self-determination of indigenous peoples around the world. One issue focuses exclusively on Africa. The other…

  9. Antarctic Meteorite Newsletter, Volume 31, No. 1

    Science.gov (United States)

    Satterwhite, Cecilia (Editor); Righter, Kevin (Editor)

    2008-01-01

    This newsletter reports 418 new meteorites from the 2004 and 2006 ANSMET seasons from the Cumulus Hills (CMS), LaPaz Ice Field (LAP), Graves Nunataks (GRA), Grosvenor Mountains (GRO), Larkman Nunatak (LAR), MacAlpine Hills (MAC), Miller Range (MIL), Roberts Massif (RBT), and Scott Glacier (SCO). These new samples include one iron, 1 eucrite, 1 mesosiderite, 6 CK chondrites (2 with pairing), 2 CV3 chondrites, 1 CM1, 7 CM2 (4 with pairing), 3 CR2 (2 with pairing), and one each of a type 3 L and H chondrites. The CK6 chondrites (LAR 06869, 06872, 06873) are unusual in that they have no discernable chondrules, extremely fine-grained texture, and are full of veins. This newsletter represents a break from recent newsletters in which we have announced many unusual and popular samples, including new lunar and martian meteorites, an unusual achondrite (GRA 06128 and 06129 the topic of a special session at this years LPSC).

  10. Bernard van Leer Foundation Newsletter, 1996.

    Science.gov (United States)

    Bernard van Leer Foundation, Newsletter, 1996

    1996-01-01

    This document consists of the four issues of the Bernard van Leer Foundation's "Newsletter" published during 1996. The newsletter covers topics related to, or about efforts to foster, the education and welfare of children around the world, and includes descriptions of programs around the world, lists of resources and publications, and…

  11. Arms Control, Disarmament, and Peace Newsletters.

    Science.gov (United States)

    Atkins, Stephen

    1986-01-01

    Considers the research value of four types of newsletters on arms control, disarmament, and peace: direct-action, informational, scholarly, and single-issue. An annotated list of 58 newsletters includes those considered most significant of their type and recommended for library collections. (EM)

  12. NITRD NewsLetter - July 2016

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — Welcome to this first issue of NITRD Leads IT, a quarterly newsletter of the Networking and Information Technology Research and Development (NITRD) Program. We...

  13. NITRD NewsLetter - October 2016

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — Welcome to the second issue of NITRD Leads IT, a quarterly newsletter of the Networking and Information Technology Research and Development (NITRD) Program. I...

  14. The Transformation of Observatory Newsletters - A Gemini Perspective

    Science.gov (United States)

    Zhang, Xiaoyu

    2015-08-01

    Astronomical observatories publish newsletters to communicate the observatory’s new discoveries and activities with its user communities, funding agencies, and general public. Gemini Observatory started publishing the newsletter in March 1992. Over the years, it transformed from a no-frills black and white publication to a full-color magazine type newsletter with a special name “GeminiFocus”. Since 2012, the contents of GeminiFocus moved from print to digital with an additional print issue of the Year in Review. The newsletter transformation is in sync with the rapid development of the internet technologies. We discuss here the evolvement of Gemini newsletter and the lessons learned.

  15. Wind Program Newsletter: October 2014 Edition (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2014-10-01

    The U.S. Department of Energy's Wind Program Newsletter, supported by the EERE Wind and Water Power Technologies office, highlights the Wind Program's key activities, events, and funding opportunities.

  16. POWERNEXT Newsletter n. 41

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-01-15

    Powernext SA is a Multilateral Trading Facility which organizes and warrants the transactions on the European power exchange and CO{sub 2} exchange markets. This issue of Powernext newsletter presents the highlights of the European power and carbon trade markets for the past months and up to January 2006 (editorial: let's give the organized market its due place). It reports on some market statistics related to prices and volumes traded on Powernext Day-Ahead{sup TM} in the case of day-ahead contracts (January 2006 to January 2007), on Powernext Futures{sup TM} in the case of medium-term contracts (December 2005 to December 2006), and on Powernext Carbon in the case of CO{sub 2} (December 2005 to December 2006). Some Powernext and market news are summarized at the end of the document. (J.S.)

  17. Society for Research in Child Development Newsletter, 2001.

    Science.gov (United States)

    Reid, Pamela Trotman, Ed.

    2001-01-01

    This document consists of the four 2001 issues of a newsletter disseminating information on the Society for Research in Child Development (SRCD) and providing a forum for important news, research, and information concerning advancements in child growth and development research. Each issue of the newsletter includes announcements and notices of…

  18. Society for Research in Child Development Newsletter, 2003.

    Science.gov (United States)

    Reid, Pamela Trotman, Ed.; Ehart, Bridget, Ed.

    2003-01-01

    This document consists of the four 2003 issues of a newsletter disseminating information on the Society for Research in Child Development (SRCD) and providing a forum for important news, research, and information concerning advancement in child growth and development research. Each issue of the newsletter includes announcements and notices of…

  19. Society for Research in Child Development Newsletter, 2002.

    Science.gov (United States)

    Reid, Pamela Trotman, Ed.; Tucker, Thelma, Ed.

    2002-01-01

    This document consists of the four 2002 issues of a newsletter disseminating information on the Society for Research in Child Development (SRCD) and providing a forum for important news, research, and information concerning advancement in child growth and development research. Each issue of the newsletter includes announcements and notices of…

  20. International Neutron Radiography Newsletter

    DEFF Research Database (Denmark)

    Domanus, Joseph Czeslaw

    1986-01-01

    At the First World Conference on Neutron Radiography i t was decided to continue the "Neutron Radiography Newsletter", published previously by J.P. Barton, as the "International Neutron Radiography Newsletter" (INRNL), with J.C. Doraanus as editor. The British Journal of Non-Destructive Testing...

  1. ICFA Beam Dynamics Newsletter

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Zvi I.; Kuczewski A.; Altinbas, Z.; Beavis, D.; Belomestnykh,; Dai, J. et al

    2012-07-01

    The Collider-Accelerator Department at Brookhaven National Laboratory is building a high-brightness 500 mA capable Energy Recovery Linac (ERL) as one of its main R&D thrusts towards eRHIC, the polarized electron - hadron collider as an upgrade of the operating RHIC facility. The ERL is in final assembly stages, with injection commisioning starting in October 2012. The objective of this ERL is to serve as a platform for R&D into high current ERL, in particular issues of halo generation and control, Higher-Order Mode (HOM) issues, coherent emissions for the beam and high-brightness, high-power beam generation and preservation. The R&D ERL features a superconducting laser-photocathode RF gun with a high quantum efficiency photoccathode served with a load-lock cathode delivery system, a highly damped 5-cell accelerating cavity, a highly flexible single-pass loop and a comprehensive system of beam instrumentation. In this ICFA Beam Dynamics Newsletter article we will describe the ERL in a degree of detail that is not usually found in regular publications. We will discuss the various systems of the ERL, following the electrons from the photocathode to the beam dump, cover the control system, machine protection etc and summarize with the status of the ERL systems.

  2. IDRA Newsletter. Volume 37, No. 8

    Science.gov (United States)

    Goodman, Christie L., Ed.

    2010-01-01

    Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Change Strategies and includes: (1) YA! Es Tiempo--The Courage to Connect (Maria "Cuca" Robledo Montecel); (2) Making…

  3. Child Rights Information Network Newsletter, 1997.

    Science.gov (United States)

    Purbrick, Becky, Ed.

    1997-01-01

    These three newsletter issues communicate activities of the Child Rights Information Network (CRIN) and report on information resources and worldwide activities concerning children and child rights. The January 1997 issue profiles CRIN members in Costa Rica, Tanzania, Germany, and Switzerland; and provides updates on the activities of projects…

  4. EDIN-USVI Clean Energy Quarterly: Volume 1, Issue 2, March 2011, Energy Development in Island Nations, U.S. Virgin Islands (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2011-03-01

    This quarterly newsletter provides timely news and information about the plans and progress of the Energy Development in Island Nations U.S. Virgin Islands pilot project, including significant events and milestones, work undertaken by each of the five working groups, and project-related renewable energy and energy efficiency projects.

  5. POWERNEXT Newsletter n. 38

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-05-15

    Powernext SA is a Multilateral Trading Facility which organizes and warrants the transactions on the European power exchange and CO{sub 2} exchange markets. This issue of Powernext newsletter presents the highlights of the European power and carbon trade markets for the past months and up to April 2006 (editorial: knowing the fair price in order to take on the energy and climate challenges, need for a better coordination of the information at the European level, a liberalization of the French power market at the standstill for the benefit of the German market and prices). It reports on some market statistics related to prices and volumes traded on Powernext Day-Ahead{sup TM} in the case of day-ahead contracts (April 2005 to April 2006), on Powernext Futures{sup TM} in the case of medium-term contracts (February to April 2006), and on Powernext Carbon in the case of CO{sub 2} (June 2005 to April 2006). Some Powernext and market news are summarized at the end of the document. (J.S.)

  6. POWERNEXT Newsletter n. 40

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-09-15

    Powernext SA is a Multilateral Trading Facility which organizes and warrants the transactions on the European power exchange and CO{sub 2} exchange markets. This issue of Powernext newsletter presents the highlights of the European power and carbon trade markets for the past months and up to September 2006 (editorial: liberalization, prices and tariffs: restoring a couple of true facts about the electricity market, partial aspect of French market's opening disrupts its operation and not the opposite, the return to a completely regulated market threatens the balance of the French electricity system and the construction of the Europe of energy). It reports on some market statistics (August 2005 to August 2006) related to prices and volumes traded on Powernext Day-Ahead{sup TM} in the case of day-ahead contracts, on Powernext Futures{sup TM} in the case of medium-term contracts, and on Powernext Carbon in the case of CO{sub 2}. Some Powernext and market news are summarized at the end of the document. (J.S.)

  7. Media Anthropologist Newsletter. Volume 1, Number 2.

    Science.gov (United States)

    James, C. A., Ed.

    The aim of media anthropologists is to provide the general public with entertaining, relevant anthropological background information through the public media. This quarterly newsletter disseminates information, promotes awareness of present physical and social issues, and offers a means of intercommunication on the topic of Media Anthropology.…

  8. CERN Diversity Newsletter - April 2017

    CERN Document Server

    AUTHOR|(CDS)2069427; Koutava, Ioanna; CERN. Geneva. HR Department

    2017-01-01

    The CERN Diversity Newsletter, informing on recent and ongoing diversity activities, and interesting reads, videos and other links related to diversity. Subscribe here: https://diversity.web.cern.ch/2015/07/subscribe-diversity-newsletter

  9. CERN Diversity Newsletter - March 2016

    CERN Document Server

    Kaltenhauser, Kristin; CERN. Geneva. HR Department

    2016-01-01

    Quarterly CERN Diversity Newsletter, informing on recent and ongoing diversity activities, and interesting reads, videos and other links related to diversity. Subscribe here: https://diversity.web.cern.ch/2015/07/subscribe-diversity-newsletter

  10. CERN Diversity Newsletter - November 2015

    CERN Document Server

    Kaltenhauser, Kristin; CERN. Geneva. HR Department

    2015-01-01

    Quarterly CERN Diversity Newsletter, informing on recent and ongoing diversity activities, and interesting reads, videos and other links related to diversity. Subscribe here: https://diversity.web.cern.ch/2015/07/subscribe-diversity-newsletter

  11. CERN Diversity Newsletter - September 2016

    CERN Document Server

    Guinot, Genevieve

    2016-01-01

    Quarterly CERN Diversity Newsletter, informing on recent and ongoing diversity activities, and interesting reads, videos and other links related to diversity. Subscribe here: https://diversity.web.cern.ch/2015/07/subscribe-diversity-newsletter

  12. Myxococcus xanthus DK1622 Coordinates Expressions of the Duplicate groEL and Single groES Genes for Synergistic Functions of GroELs and GroES

    Directory of Open Access Journals (Sweden)

    Yue-zhong Li

    2017-04-01

    Full Text Available Chaperonin GroEL (Cpn60 requires cofactor GroES (Cpn10 for protein refolding in bacteria that possess single groEL and groES genes in a bicistronic groESL operon. Among 4,861 completely-sequenced prokaryotic genomes, 884 possess duplicate groEL genes and 770 possess groEL genes with no neighboring groES. It is unclear whether stand-alone groEL requires groES in order to function and, if required, how duplicate groEL genes and unequal groES genes balance their expressions. In Myxococcus xanthus DK1622, we determined that, while duplicate groELs were alternatively deletable, the single groES that clusters with groEL1 was essential for cell survival. Either GroEL1 or GroEL2 required interactions with GroES for in vitro and in vivo functions. Deletion of groEL1 or groEL2 resulted in decreased expressions of both groEL and groES; and ectopic complementation of groEL recovered not only the groEL but also groES expressions. The addition of an extra groES gene upstream groEL2 to form a bicistronic operon had almost no influence on groES expression and the cell survival rate, whereas over-expression of groES using a self-replicating plasmid simultaneously increased the groEL expressions. The results indicated that M. xanthus DK1622 cells coordinate expressions of the duplicate groEL and single groES genes for synergistic functions of GroELs and GroES. We proposed a potential regulation mechanism for the expression coordination.

  13. The CERN & Society programme launches its newsletter

    CERN Multimedia

    Matteo Castoldi

    2016-01-01

    The newsletter will be issued quarterly. Sign up to remain informed about the latest initiatives of the CERN & Society programme!    The CERN & Society programme encompasses projects in the areas of education and outreach, innovation and knowledge exchange, and culture and creativity that spread the CERN spirit of scientific curiosity for the inspiration and benefit of society. The programme is funded primarily by the CERN & Society Foundation, a charitable foundation established by CERN and supported by individuals, trusts, organisations and commercial companies. The projects are inspired or enabled by CERN but lie outside of the Laboratory’s specific research mandate. We especially want to help young talent from around the world to flourish in the future. The programme is now launching its newsletter, which will be issued quarterly. Everybody who wants to be informed about CERN & Society’s activities, stay up-to-date with its latest in...

  14. CERN Diversity Newsletter - July 2015

    CERN Document Server

    Kaltenhauser, Kristin; CERN. Geneva. HR Department

    2015-01-01

    The first official edition of the CERN Diversity Newsletter, informing on recent and ongoing diversity activities, and interesting reads, videos and other links related to diversity. Subscribe here: https://diversity.web.cern.ch/2015/07/subscribe-diversity-newsletter

  15. National Cartographic Information Center Newsletter No. 4

    Science.gov (United States)

    ,

    1976-01-01

    Last week, the editor of this publication was told to start signing the introduction. Something to do with credit given for work done. We look at it in the unfortunate light of accountability; our days under the bushel of anonymity are over. Speaking of accountability, it's about time we gave some recognition to the Newsletter's unknowing progenitor, John Wright, of the British Directorate of Overseas Surveys. Editorially and stylistically, the NCIC Newsletter owes him a large debt. Last month we received a suggestion from a reader that the Newsletter begin consistently listing prices for new products. In the publishing business, however, there is an infallible law of inflation prices increase as soon as they appear in print. We do try to quote exact prices where possible, and as our reader suggested, ballpark figures when we have to. In nearly all cases, additional information is available either by contacting the addresses listed in the article or indexed in the back or by calling NCIC's User Services Section. Numerous bits and pieces of information make up the bulk of this issue. Among them are the possibility of the Geological Survey issuing readable indexes to available topographic maps, the development of an NCIC classification system for U.S. cartographic data, and information on the publication of prototype topographic-bathymetric maps. Lastly, here is our quarterly solicitation for suggestions, comments, criticism, notes, and information for publication. Call it your bicentennial contribution to participatory democracy.

  16. Public health lives: Gro Harlem Brundtland.

    Science.gov (United States)

    Yach, D; von Schirnding, Y

    2014-02-01

    Health has been a deeply personal, professional and political dimension of Gro Harlem Brundtland's life. Her decision to study breast feeding while an MPH student at Harvard in 1964, or her desire to tackle tobacco being influenced by her father sending her as a 10-year old girl to buy his cigarettes at the local store, or her deeply personal family experience of mental ill health all led her to take actions on the global stage to address these and other issues that evidence showed would have global impact. Her impact on global health started with a commitment to make a difference in the lives of people, particularly those in greatest need. Copyright © 2013 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  17. April 2016 Pacific Southwest Newsletter

    Science.gov (United States)

    EPA Pacific Southwest Newsletter for April 2016: University of Arizona Reduces Food Waste, Cleaning Up Underground Fuel Tanks in Fresno, The Argonaut Mine, Ensuring Clean Water in Nevada,Cleaning Up Groundwater in Whittier, California, and more!

  18. Communication and Negotiation. Growing Pains: Sex Education for Parents. A Newsletter Series. Letter IV.

    Science.gov (United States)

    Polulech, Joan Burgess; Nuttall, Paul

    This document presents the fourth of five newsletters on sex education for parents. The newsletters were designed to help parents increase their ability to communicate with their adolescents about sexual issues. They explore the origins of the parents' feelings about sex; teach the importance of a healthy self-concept and how to build it in the…

  19. Sexuality. Growing Pains: Sex Education for Parents. A Newsletter Series. Letter I.

    Science.gov (United States)

    Polulech, Joan Burgess; Nuttall, Paul

    This document presents the first of five newsletters on sex education for parents. The newsletters were designed to help parents increase their ability to communicate with their adolescents about sexual issues. They explore the origins of the parents' feelings about sex; teach the importance of a healthy self-concept and how to build it in the…

  20. Talking about Sex. Growing Pains: Sex Education for Parents. A Newsletter Series. Letter V.

    Science.gov (United States)

    Polulech, Joan Burgess; Nuttall, Paul

    This document presents the fifth of five newsletters on sex education for parents. The newsletters were designed to help parents increase their ability to communicate with their adolescents about sexual issues. They explore the origins of the parents' feelings about sex; teach the importance of a healthy self-concept and how to build it in the…

  1. Puberty/Adolescence. Growing Pains: Sex Education for Parents. A Newsletter Series. Letter III.

    Science.gov (United States)

    Polulech, Joan Burgess; Nuttall, Paul

    This document presents the third of five newsletters on sex education for parents. The newsletters were designed to help parents increase their ability to communicate with their adolescents about sexual issues. They explore the origins of the parents' feelings about sex; teach the importance of a healthy self-concept and how to build it in the…

  2. Self-Esteem. Growing Pains: Sex Education for Parents. A Newsletter Series. Letter II.

    Science.gov (United States)

    Polulech, Joan Burgess; Nuttall, Paul

    This document presents the second of five newsletters on sex education for parents. The newsletters were designed to help parents increase their ability to communicate with their adolescents about sexual issues. They explore the origins of the parents' feelings about sex; teach the importance of a healthy self-concept and how to build it in the…

  3. A Work of ARTE: The Newsletter of the Assembly of Rural Teachers of English, 1993.

    Science.gov (United States)

    Work of ARTE, 1993

    1993-01-01

    This document consists of the three issues of the ARTE newsletter published during 1993. This newsletter describes organizational objectives and activities of the Assembly of Rural Teachers of English (ARTE), and presents articles of interest to rural English teachers. Articles discuss: (1) promoting and capitalizing on positive feelings of family…

  4. Powernext, newsletter no.18

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-03-01

    This newsletter provides information and statistical data on the four business unit of Powernext: Powernext Day-Ahead, Powernext Carbon, Powernext Futures and Powernext Weather. Powernext Day-Ahead provides a short term price reference to manage the volume risk. Powernext Day-Ahead counts close to 50 members among producers, suppliers, eligible consumers, etc. Powernext Carbon is a spot market of CO{sub 2} allowances. The market model is the result of a three-fold partnership between Powernext, Caisse des Depots and Euronext. Powernext Carbon counts close to 30 active members. More than 2 Million tonnes of CO{sub 2} have been traded since the launch of the market on 24 June. Powernext Carbon has made a name for itself as the most liquid CO{sub 2} allowances spot market in Europe to date. Powernext Futures has made a name for itself as a price reference for the medium term market. Its market makers and members guarantee a high-quality market over a time period going up until 2008. Powernext Weather is a range of economically weather driven temperature indices provided by our partner Meteo France. These indices are decision making or hedging tools. This analysis concerns February and March 2004. (A.L.B.)

  5. Powernext, newsletter no.27

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This newsletter provides information and statistical data on the four business unit of Powernext: Powernext Day-Ahead, Powernext Carbon, Powernext Futures and Powernext Weather. Powernext Day-Ahead provides a short term price reference to manage the volume risk. Powernext Day-Aheado counts close to 50 members among producers, suppliers, eligible consumers, etc. Powernext Carbon is a spot market of CO{sub 2} allowances. The market model is the result of a three-fold partnership between Powernext, Caisse des Depots and Euronext. Powernext Carbon counts close to 30 active members. More than 2 Million tonnes of CO{sub 2} have been traded since the launch of the market on 24 June. Powernext Carbon has made a name for itself as the most liquid CO{sub 2} allowances spot market in Europe to date. Powernext Futures has made a name for itself as a price reference for the medium term market. Its market makers and members guarantee a high-quality market over a time period going up until 2008. Powernext Weather is a range of economically weather driven temperature indices provided by our partner Meteo France. These indices are decision making or hedging tools. This analysis concerns February and march 2005. (A.L.B.)

  6. Powernext, newsletter no.19

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-04-01

    This newsletter provides information and statistical data on the four business unit of Powernext: Powernext Day-Ahead, Powernext Carbon, Powernext Futures and Powernext Weather. Powernext Day-Ahead provides a short term price reference to manage the volume risk. Powernext Day-Ahead counts close to 50 members among producers, suppliers, eligible consumers, etc. Powernext Carbon is a spot market of CO{sub 2} allowances. The market model is the result of a three-fold partnership between Powernext, Caisse des Depots and Euronext. Powernext Carbon counts close to 30 active members. More than 2 Million tonnes of CO{sub 2} have been traded since the launch of the market on 24 June. Powernext Carbon has made a name for itself as the most liquid CO{sub 2} allowances spot market in Europe to date. Powernext Futures has made a name for itself as a price reference for the medium term market. Its market makers and members guarantee a high-quality market over a time period going up until 2008. Powernext Weather is a range of economically weather driven temperature indices provided by our partner Meteo France. These indices are decision making or hedging tools. This analysis concerns April 2004. (A.L.B.)

  7. Powernext, newsletter no.21

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This newsletter provides information and statistical data on the four business unit of Powernext: Powernext Day-Ahead, Powernext Carbon, Powernext Futures and Powernext Weather. Powernext Day-Ahead provides a short term price reference to manage the volume risk. Powernext Day-Ahead counts close to 50 members among producers, suppliers, eligible consumers, etc. Powernext Carbon is a spot market of CO{sub 2} allowances. The market model is the result of a three-fold partnership between Powernext, Caisse des Depots and Euronext. Powernext Carbon counts close to 30 active members. More than 2 Million tonnes of CO{sub 2} have been traded since the launch of the market on 24 June. Powernext Carbon has made a name for itself as the most liquid CO{sub 2} allowances spot market in Europe to date. Powernext Futures has made a name for itself as a price reference for the medium term market. Its market makers and members guarantee a high-quality market over a time period going up until 2008. Powernext Weather is a range of economically weather driven temperature indices provided by our partner Meteo France. These indices are decision making or hedging tools. This analysis concerns July 2004. (A.L.B.)

  8. Powernext, newsletter no.26

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-01-01

    This newsletter provides information and statistical data on the four business unit of Powernext: Powernext Day-Ahead, Powernext Carbon, Powernext Futures and Powernext Weather. Powernext Day-Ahead provides a short term price reference to manage the volume risk. Powernext Day-Ahead counts close to 50 members among producers, suppliers, eligible consumers, etc. Powernext Carbon is a spot market of CO{sub 2} allowances. The market model is the result of a three-fold partnership between Powernext, Caisse des Depots and Euronext. Powernext Carbon counts close to 30 active members. More than 2 Million tonnes of CO{sub 2} have been traded since the launch of the market on 24 June. Powernext Carbon has made a name for itself as the most liquid CO{sub 2} allowances spot market in Europe to date. Powernext Futures has made a name for itself as a price reference for the medium term market. Its market makers and members guarantee a high-quality market over a time period going up until 2008. Powernext Weather is a range of economically weather driven temperature indices provided by our partner Meteo France. These indices are decision making or hedging tools. This analysis concerns January 2005. (A.L.B.)

  9. Powernext, newsletter no.20

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-05-01

    This newsletter provides information and statistical data on the four business unit of Powernext: Powernext Day-Ahead, Powernext Carbon, Powernext Futures and Powernext Weather. Powernext Day-Ahead provides a short term price reference to manage the volume risk. Powernext Day-Ahead counts close to 50 members among producers, suppliers, eligible consumers, etc. Powernext Carbon is a spot market of CO{sub 2} allowances. The market model is the result of a three-fold partnership between Powernext, Caisse des Depots and Euronext. Powernext Carbon counts close to 30 active members. More than 2 Million tonnes of CO{sub 2} have been traded since the launch of the market on 24 June. Powernext Carbon has made a name for itself as the most liquid CO{sub 2} allowances spot market in Europe to date. Powernext Futures has made a name for itself as a price reference for the medium term market. Its market makers and members guarantee a high-quality market over a time period going up until 2008. Powernext Weather is a range of economically weather driven temperature indices provided by our partner Meteo France. These indices are decision making or hedging tools. This analysis concerns May 2004. (A.L.B.)

  10. Scientific Newsletters and Electronic Publishing - the Example of GCNEWS

    Science.gov (United States)

    Falcke, H.; Cotera, A.

    The exponentially growing number of papers published monthly in peer reviewed journals, in combination with the advances made in electronic publishing, has resulted in the creation of several electronically distributed newsletters. Typically, these newsletters focus on a specialized field within astrophysics research and each serve a few hundred subscribers. Since almost all recognized astronomical research papers are published in a few traditional journals, each covering a large range of subtopics, these newsletters can provide the benefits of specialized journals without replacing the traditional means of publication. The Galactic Center Newsletter (GCNEWS) is a recent addition to this growing trend. Each issue features abstracts of recently submitted or accepted papers, shorter commentary articles, and solicited articles of general interest to the Galatic Center community. The Newsletter is distributed as a PostScript file and in HTML format (http://www.astro.umd.edu/~gcnews). Papers can be submitted conveniently in any Tex/ASCII format, and most abstracts are automatically reformatted and extracted. Because of its user friendly style and the ease with which researchers around the world are now able to stay abreast of recent developments in this field, GCNEWS was accepted very quickly by the international Galactic Center community. GCNEWS now provides a quick, convenient, and very cost-efficient innovative form of communicating scientific results in Galactic Center research.

  11. Clean Cities Now: Vol. 18, No. 1, Spring 2014 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2014-04-01

    Spring 2014 edition of the biannual newsletter of the U.S. Department of Energy's Clean Cities program. Each issue contains program news, success stories, and information about tools and resources to assist in the deployment of alternative fuels, advanced vehicles, idle reduction, fuel efficiency improvements, and other measures to cut petroleum use in transportation.

  12. Council on Anthropology and Education Newsletter. Volume III, Number 1.

    Science.gov (United States)

    Singleton, John Ed.

    General information on format, included, materials, broad concerns, objectives, and availability of the newsletter are described in Volume I, ED 048 049. This issue focuses on ethnology, offering two papers presented at the American Anthropological Association symposiums. The lead paper presents a psycho-cultural developmental approach to the…

  13. Nutrition Frontiers E-Newsletter | Division of Cancer Prevention

    Science.gov (United States)

    The Nutritional Science Research Group, Division of Cancer Prevention at NCI issues a quarterly electronic newsletter, Nutrition Frontiers, that highlights emerging evidence linking diet to cancer prevention and showcases recent findings about who will likely benefit most from dietary change. |

  14. Bilingual Newspapers, Newsletters, and Periodicals.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Bilingual Resource Center.

    This booklet presents a list of 34 Spanish-language newspapers published in the United States and Latin America, 23 newsletters with information in the field of bilingual education, and 42 magazines published in Spanish and available in the U.S. Information includes the name of the publication, the city or country of origin, the address of the…

  15. Press Censorship Newsletter No. VI.

    Science.gov (United States)

    Reporters Committee for Freedom of the Press, Washington, DC. Legal Defense and Research Fund.

    A compendium of legal actions affecting the First Amendment and freedom of information interests of all the media on the federal, state, and local levels, this newsletter contains 316 indexed summaries of "Media Law Reports." The abstracts are arranged in 10 categories: prior restraints on publication and distribution, freedom of information,…

  16. NAWIG News: The Quarterly Newsletter of the Native American Wind Interest Group, Spring 2009

    Energy Technology Data Exchange (ETDEWEB)

    2009-01-01

    As part of its Native American outreach, DOE's Wind Powering America program has initiated a NAWIG newsletter to present Native American wind information, including projects, interviews with pioneers, issues, WPA activities, and related events. It is our hope that this newsletter will both inform and elicit comments and input on wind development in Indian Country. This issue profiles the Banner Wind Project in Nome, Alaska, and a new Native project in Kansas.

  17. National Cartographic Information Center Newsletter No. 6

    Science.gov (United States)

    ,

    1977-01-01

    As a rule we don't carry personnel information additions, subtractions, etc., in the newsletter. This is a technical publication, not a forum for office baseball league scores. Now, having got that disclaimer out of the way, we wanted to note that Dick Swinnerton, Chief of NCIC since the Center's inception in 1974, has left us. Dick was recently chosen as Chief of the Topographic Divisions's Western Mapping Center (a move up and, geographically at least, to the left). When Dick arrived NCIC consisted of 4 briefing books and an interesting concept. 3 years later we have 10 books and a thriving organization. We shall miss him. This issue contains what we hope is an interesting collection of cartographic news, including articles about recent Federal mapping agreements, new publication announcements, notes on the second NCIC coordinating conference, and a cumulative index for the spring 1975 to summer 1977 issues.

  18. Southern Great Plains Newsletter

    Energy Technology Data Exchange (ETDEWEB)

    J. Prell

    2010-09-01

    This months issue contains the following articles: (1) Scientists convene at SGP site for complex convective cloud experiment; (2) VORTEX2 spins down; (3) Sunphotometer supports SPARTICUS (a Sun and Aureole Measurement imaging sunphotometer) campaign and satellite validation studies; and (4) Ceilometer represents first deployment of new ground-based instruments from Recovery Act.

  19. The morphogenesis of herpes simplex virus type 1 in infected parental mouse L fibroblasts and mutant gro29 cells

    DEFF Research Database (Denmark)

    Jensen, Helle Lone; Norrild, Bodil

    2003-01-01

    Mutants of cell lines and viruses are important biological tools. The pathway of herpesvirus particle maturation and egress are contentious issues. The mutant gro29 line of mouse L cells is defective for egress of herpes simplex virus type 1 (HSV-1) virions, and a candidate for studies of virus......-cell interactions. The properties of uninfected and HSV-1-infected L fibroblasts and gro29 cells investigated by protein assay, immunoblot, titration assay, immunofluorescence light microscopy and immunogold cryosection electron microscopy are reported. The ultrastructure of both HSV-1-infected L and gro29 cells...

  20. EVALUATION OF THE MASTER MARKETER NEWSLETTER

    OpenAIRE

    McCorkle, Dean A.; Waller, Mark L.; Amosson, Stephen H.; Smith, Jackie; Bevers, Stanley J.; Borchardt, Robert

    2001-01-01

    Several support programs have been developed to help support, reinforce, enhance, and improve the effectiveness of the educational experience of Master Marketer graduates and other marketing club participants. One of those products, the Master Marketer Newsletter, is currently mailed to over 700 Master Marketer graduates and Extension faculty on a quarterly basis. In the June 2000 newsletter, a questionnaire was sent to newsletter recipients asking them to evaluate the various sections of the...

  1. Newsletters, Digests, People and Partners- IPinCH Project

    OpenAIRE

    Intellectual Property Issues in Cultural Heritage

    2016-01-01

    The Intellectual Property Issues in Cultural Heritage (IPinCH) project is a seven-year international research initiative based at Simon Fraser University, in British Columbia, Canada. Our work explores the rights, values, and responsibilities of material culture, cultural knowledge and the practice of heritage research. News about the project is shared with our partners through monthly email Digests and semi annually through newsletters. IPinCH is a collaboration of scholars, student...

  2. International Work Group for Indigenous Affairs Newsletter, July 1991-December 1992 = Boletin de Grupo Internacional de Trabajo sobre Asuntos Indigenas, Septiembre 1991-Diciembre 1992.

    Science.gov (United States)

    IWGIA Newsletter, 1992

    1992-01-01

    This document contains seven consecutive English-language issues of the IWGIA Newsletter, from July 1991 through December 1992, followed by the seven corresponding issues in Spanish. These newsletters provide educators with a resource on the history, current conditions, and struggles for self-determination of indigenous peoples around the world.…

  3. International Work Group for Indigenous Affairs Newsletter, July 1991-December 1992 = Boletin de Grupo Internacional de Trabajo sobre Asuntos Indigenas, Septiembre 1991-Diciembre 1992.

    Science.gov (United States)

    IWGIA Newsletter, 1992

    1992-01-01

    This document contains seven consecutive English-language issues of the IWGIA Newsletter, from July 1991 through December 1992, followed by the seven corresponding issues in Spanish. These newsletters provide educators with a resource on the history, current conditions, and struggles for self-determination of indigenous peoples around the world.…

  4. Wind Program Newsletter, May 2016 Edition

    Energy Technology Data Exchange (ETDEWEB)

    2016-05-01

    The U.S. Department of Energy Wind Program Newsletter provides wind industry stakeholders and the public with information about the Wind Program R&D efforts funded by the Wind and Water Power Technologies Office. The newsletter comes out twice a year and is sent electronically to subscribers and distributed in hard copy to conference attendees.

  5. Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES

    Science.gov (United States)

    Chi, Haixia; Wang, Xiaoqiang; Li, Jiqiang; Ren, Hao; Huang, Fang

    2015-11-01

    The in vitro folding of newly translated human CC chemokine receptor type 5 (CCR5), which belongs to the physiologically important family of G protein-coupled receptors (GPCRs), has been studied in a cell-free system supplemented with the surfactant Brij-35. The freshly synthesized CCR5 can spontaneously fold into its biologically active state but only slowly and inefficiently. However, on addition of the GroEL-GroES molecular chaperone system, the folding of the nascent CCR5 was significantly enhanced, as was the structural stability and functional expression of the soluble form of CCR5. The chaperonin GroEL was partially effective on its own, but for maximum efficiency both the GroEL and its GroES lid were necessary. These results are direct evidence for chaperone-assisted membrane protein folding and therefore demonstrate that GroEL-GroES may be implicated in the folding of membrane proteins.

  6. GRoW Buffalo Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Bohm, Martha [Univ. at Buffalo, NY (United States)

    2016-04-17

    This document provides final reporting on the GRoW Home, University at Buffalo's entry to the 2015 Solar Decathlon competition in Irvine, CA. The report summarizes fundraising efforts, documents media outreach, lists online presence, analyzes the organizer's communication, describes post-competition life of the house and future employment plans for student team members. Last, it suggests improvements for future decathlons.

  7. Progress in molecular chaperon GroEL%GroEL分子伴侣研究进展

    Institute of Scientific and Technical Information of China (English)

    张经余; 赵志虎; 蔡民华

    2001-01-01

    大肠杆菌的GroEL是同型寡聚复合体,由14个相对分子质量58×103亚基组成背靠背的双环结构。它在新生蛋白质的正确折叠和组装以及在热或化学逆境下变性蛋白质的恢复过程中起重要作用。同时,在大肠杆菌的跨膜转运及插入细胞质膜方面都起重要作用。这些活动依赖于GroEL与底物蛋白的疏水片断的相互作用。综述了Hsp60分子伴侣系统中研究得比较清楚的GroEL的晶体结构、功能及作用机理等方面的研究进展。%Molecular chaperon GroEL of E.coli is a homo-oligomeric complex composed of 14 58kDa subunits arranged in two rings stacked back to back, which is required for correct folding and assambly of newly synthesized proteins and for recovery of the cell after exposure to either thermal or chemical stress .Apart from these functions, GroEL chaperon is able to play a role in protein translocation across or insertion into the cytoplasmic membrane of E.coli. These actions depend on the interaction between GroE chaperionin system and the hydrophobic side chains .

  8. Lewy Body Digest eNewsletter

    Science.gov (United States)

    ... Host a LBD5K fundraise First Giving Fundraising Everyday Hero raise awareness awareness month photos raise LBD awareness ... LBDA December 2016 Newsletter A Father and Son Journey Giving is Easy with Amazon Resources Available to ...

  9. Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein

    DEFF Research Database (Denmark)

    Tang, Sheila Tuyet; Chang, HC; Roeben, A

    2006-01-01

    GroEL and GroES form a chaperonin nano-cage for proteins up to similar to 60 kDa to fold in isolation. Here we explored the structural features of the chaperonin cage critical for rapid folding of encapsulated substrates. Modulating the volume of the GroEL central cavity affected folding speed....... Additionally, interactions with the C-terminal, mildly hydrophobic Gly-Gly-Met repeat sequences of GroEL protruding into the cavity, and repulsion effects from the negatively charged cavity wall were required for rapid folding of some proteins. We suggest that by combining these features, the chaperonin cage...

  10. Sequence analysis of the Legionella micdadei groELS operon

    DEFF Research Database (Denmark)

    Hindersson, P; Høiby, N; Bangsborg, Jette Marie

    1991-01-01

    shock expression signals were identified upstream of the L. micdadei groEL gene. Further upstream, a poly-T region, also a feature of the sigma 32-regulated Escherichia coli groELS heat shock operon, was found. Despite the high degree of homology of the expression signals in E. coli and L. micdadei...

  11. Anthropology and Language Science in Educational Development Newsletter, No. 2/3.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Structures and Content of Life-Long Education.

    This issue of the ALSED newsletter contains: (1) a description of the Anthropology and Language Science in Educational Development (ALSED) program; (2) information on the meeting of experts on diversification of methods and techniques for teaching a second language or foreign languages (Paris, Unesco, 15-20 September, 1975), which discussed such…

  12. Encore: A Selction of Articles from ERIC/ECE Newsletters (Jan. 1971-Dec. 1972).

    Science.gov (United States)

    ERIC Clearinghouse on Early Childhood Education, Champaign, IL.

    This compilation of articles from newsletters issued by the ERIC Clearinghouse on Early Childhood Education, (January 1971 - December 1972) includes a wide variety of topics such as: teachers' developmental stages, family day care in Pasadena, television violence, children's altruistic lying, and the Home Start program. Also included is a complete…

  13. New England Wind Forum: A Wind Powering America Project - Newsletter #6 - September 2010, (NEWF)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, R.; Gifford, J.; Leeds, T.; Bauer, S.

    2010-09-01

    Wind Powering America program launched the New England Wind Forum (NEWF) in 2005 to provide a single comprehensive source of up-to-date, Web-based information on a broad array of wind energy issues pertaining to New England. The NEWF newsletter provides New England stakeholders with updates on wind energy development in the region.

  14. Second Language Acquisition Notes and Topics, Volume 9, Number 1. A Newsletter for Researchers and Teachers.

    Science.gov (United States)

    Chun, Judith, Ed.

    This issue of the "SLANT" Newsletter for researchers in second language acquisition is highlighted by a report of research on second language acquisition by immigrant workers in West Germany (including research in progress and a bibliography). Also included are reports from various language acquisition conferences; a listing of summer…

  15. Early Childhood Education. National Dropout Prevention Center/Network Newsletter. Volume 22, Number 2

    Science.gov (United States)

    Duckenfield, Marty, Ed.

    2011-01-01

    The "National Dropout Prevention Newsletter" is published quarterly by the National Dropout Prevention Center/Network. This issue contains the following articles: (1) Laying the Foundation for Success (Mary Caputo); (2) Ready or Not? (Laura Koenig); (3) Every Child A School-Ready Child (Leah Newkirk Meunier); (4) Parents As Teachers (Erin Garner);…

  16. SITREP: The NPS Maritime Defense and Security Research Program Newsletter ; v. 38 (April 2009)

    OpenAIRE

    2009-01-01

    This April 2009 issue of the Naval Postgraduate School (NPS) Maritime Defense and Security Research Program Newsletter highlights the following research: "Join MDA [Maritime Defense and Awareness] Outreach on ODNI [Office of the Director of National Intelligence] Bridge" and "NPS Cooperative Operations and Applied Science & Technology Studies." It also provides links to future events, reports, articles, and NPS Theses regarding maritime defense and security.

  17. Palestine Refugees Today. Human Rights Day: Twenty-Fifth Anniversary. Newsletter Number 76.

    Science.gov (United States)

    United Nations Relief and Works Agency, New York, NY.

    A special issue of the United Nations Relief and Works Agency (UNRWA) newsletter relates the ideals of human rights as carried out for the Palestine refugees. An overview of the publication and its contents is followed by a copy of the Universal Declaration of Human Rights. Three articles--The Right to Education, An Adequate Standard of Living,…

  18. The National Research Center on the Gifted and Talented Newsletter, 2001.

    Science.gov (United States)

    Gubbins, E. Jean, Ed.; Siegle, Del, Ed.

    2001-01-01

    This document contains the spring and fall 2001 newsletters of the National Research Center on the Gifted and Talented (NRC/GT). The spring 2001 issue contains the following featured articles: (1) "Using Gifted Education Strategies with All Students" (E. Jean Gubbins and NRC/GT Research Team); (2) "New Center for the Pyschology of…

  19. Second Language Acquisition Notes and Topics, Numbers 1 through 5. A Newsletter for Researchers.

    Science.gov (United States)

    San Francisco State Univ., CA.

    The first five issues of the "SLANT" Newsletter for researchers in second language acquisition are included. Highlights include: (1) a bibliography on theories of second language learning by Larry Selinker, (2) descriptions of research in progress in England, and (3) the syllabus for the diploma in applied lingusitics at the University…

  20. GroEL of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31 exhibits GroES and ATP-independent refolding activity.

    Science.gov (United States)

    Potnis, Akhilesh A; Rajaram, Hema; Apte, Shree K

    2016-03-01

    The nitrogen-fixing cyanobacterium, Anabaena L-31 has two Hsp60 proteins, 59 kDa GroEL coded by the second gene of groESL operon and 61 kDa Cpn60 coded by cpn60 gene. Anabaena GroEL formed stable higher oligomer (>12-mer) in the presence of K(+) and prevented thermal aggregation of malate dehydrogenase (MDH). Using three protein substrates (MDH, All1541 and green fluorescent protein), it was found that the refolding activity of Anabaena GroEL was lower than that of Escherichia coli GroEL, but independent of both GroES and ATP. This correlated with in vivo data. GroEL exhibited ATPase activity which was enhanced in the presence of GroES and absence of a denatured protein, contrary to that observed for bacterial GroEL. However, a significant role for ATP could not be ascertained during in vitro folding assays. The monomeric Cpn60 exhibited much lower refolding activity than GroEL, unaffected by GroES and ATP. In vitro studies revealed inhibition of the refolding activity of Anabaena GroEL by Cpn60, which could be due to their different oligomeric status. The role of GroES and ATP may have been added during the course of evolution from the ancient cyanobacteria to modern day bacteria enhancing the refolding ability and ensuring wider scope of substrates for GroEL.

  1. Dataset concerning GroEL chaperonin interaction with proteins

    Directory of Open Access Journals (Sweden)

    V.V. Marchenkov

    2016-03-01

    Full Text Available GroEL chaperonin is well-known to interact with a wide variety of polypeptide chains. Here we show the data related to our previous work (http://dx.doi.org/10.1016/j.pep.2015.11.020 [1], and concerning the interaction of GroEL with native (lysozyme, α-lactalbumin and denatured (lysozyme, α-lactalbumin and pepsin proteins in solution. The use of affinity chromatography on the base of denatured pepsin for GroEL purification from fluorescent impurities is represented as well.

  2. Anglo-Australian Observatory August 2009 newsletter

    CERN Document Server

    Dobbie, Paul

    2009-01-01

    The August 2009 edition of the AAO newsletter contains articles on observations of the lunar impact of the Kaguya satellite, mapping the ISM towards Omega Centauri, early results from the Anglo-Australian Rocky Planet search, details of a new AAOmega observing mode, the new telescope control system and a number of regular features.

  3. Solar Energy Technologies Program Newsletter - July 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-07-01

    This quarterly newsletter is intended for participants and stakeholders in the DOE Solar Program. The content includes features on technology development, market transformation, and policy analysis for solar. Highlights include solar industry updates, DOE funding opportunity announcements and awards, and national laboratory technology developments.

  4. Solar Energy Technologies Program Newsletter - September 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-10-01

    This quarterly newsletter is intended for participants and stakeholders in the DOE Solar Program. The content includes features on technology development, market transformation, and policy analysis for solar. Highlights include solar industry updates, DOE funding opportunity announcements and awards, and national laboratory technology developments.

  5. Strategisches Informationsmanagement in Großprojekten der Industrie

    OpenAIRE

    Gemmel, Gunter

    2013-01-01

    Unternehmen gründen Projekte, um einmalige, zeitlich begrenzte Vorhaben effizient zu realisieren. Gerade in der Industrie zeigt sich diese Vorgehensweise häufig in Form von Großprojekten. Das IT-Management zur Unterstützung dieser Industrieprojekte steht dabei vor besonderen, charakteristischen Herausforderungen. Diese Arbeit beantwortet die Forschungsfrage, wie die bestehenden Konzepte des strategi- schen Informationsmanagements im speziellen Kontext von Großprojekten der Industrie angewe...

  6. Anglo-Australian Observatory February 2009 newsletter

    CERN Document Server

    Dobbie, P

    2009-01-01

    The February 2009 edition of the AAO newsletter contains articles on the preliminary results from the WiggleZ dark energy survey, the analysis of near-IR observations of the galaxy IRAS18293-3413, the early results from the SPIRAL IFU investigation of the dynamics of a sample of nearby star forming galaxies, a summary of the successful outcome of the first on-sky test of photonic OH suppression and a number of regular features.

  7. GroEL mediates protein folding with a two successive timer mechanism.

    Science.gov (United States)

    Ueno, Taro; Taguchi, Hideki; Tadakuma, Hisashi; Yoshida, Masasuke; Funatsu, Takashi

    2004-05-21

    GroEL encapsulates nonnative substrate proteins in a central cavity capped by GroES, providing a safe folding cage. Conventional models assume that a single timer lasting approximately 8 s governs the ATP hydrolysis-driven GroEL chaperonin cycle. We examine single molecule imaging of GFP folding within the cavity, binding release dynamics of GroEL-GroES, ensemble measurements of GroEL/substrate FRET, and the initial kinetics of GroEL ATPase activity. We conclude that the cycle consists of two successive timers of approximately 3 s and approximately 5 s duration. During the first timer, GroEL is bound to ATP, substrate protein, and GroES. When the first timer ends, the substrate protein is released into the central cavity and folding begins. ATP hydrolysis and phosphate release immediately follow this transition. ADP, GroES, and substrate depart GroEL after the second timer is complete. This mechanism explains how GroES binding to a GroEL-substrate complex encapsulates the substrate rather than allowing it to escape into solution.

  8. LBRIG Newsletter (Newsletter of the Language by Radio Interest Group). Vol. IV, No. 1.

    Science.gov (United States)

    Garfinkel, Alan, Ed.; And Others

    The Language by Radio Interest Group (LBRIG) Newsletter, volume 4, number 1, opens with an appeal to subscribers to contribute articles, reports, notes etc. The annual ACTFL workshop held on 29 Nov. 1975 is then described. It features a report by Dolores Zesiger, instructor in Spanish at Logan (Ohio) High School, on the interesting use of local…

  9. Manuelle Montage von Großgeräten

    Science.gov (United States)

    Lotter, Bruno

    Die manuelle Montage von Großgeräten — wie. z. B. Maschinen, Traktoren, Haushaltsgeräte, PKW-Motoren, LKW-Achsen, Schaltschränke usw. — wird in ihrer Montagestruktur vorrangig durch das Produktgewicht, die Produktabmessung und die Produktionsrate bestimmt.

  10. Probing the dynamic process of encapsulation in Escherichia coli GroEL.

    Directory of Open Access Journals (Sweden)

    Toshifumi Mizuta

    Full Text Available Kinetic analyses of GroE-assisted folding provide a dynamic sequence of molecular events that underlie chaperonin function. We used stopped-flow analysis of various fluorescent GroEL mutants to obtain details regarding the sequence of events that transpire immediately after ATP binding to GroEL and GroEL with prebound unfolded proteins. Characterization of GroEL CP86, a circularly permuted GroEL with the polypeptide ends relocated to the vicinity of the ATP binding site, showed that GroES binding and protection of unfolded protein from solution is achieved surprisingly early in the functional cycle, and in spite of greatly reduced apical domain movement. Analysis of fluorescent GroEL SR-1 and GroEL D398A variants suggested that among other factors, the presence of two GroEL rings and a specific conformational rearrangement of Helix M in GroEL contribute significantly to the rapid release of unfolded protein from the GroEL apical domain.

  11. Differential T-cell recognition of native and recombinant Mycobacterium tuberculosis GroES

    DEFF Research Database (Denmark)

    Rosenkrands, I; Weldingh, K; Ravn, P

    1999-01-01

    Mycobacterium tuberculosis GroES was purified from culture filtrate, and its identity was confirmed by immunoblot analysis and N-terminal sequencing. Comparing the immunological recognition of native and recombinant GroES, we found that whereas native GroES elicited a strong proliferative response...

  12. FIOH-sponsored newsletter misrepresents asbestos hazards in Zimbabwe

    NARCIS (Netherlands)

    Bailar, J.C.; Ballal, S.G.; Boback, M.; Castleman, B.; Chee, H.L.; Cherniack, M.; Christiani, D.; Cicolella, A.; Pool, D' J.F.; Egilman, D.; Frank, A.L.; Garcia, M.A.; Giannasi, F.; Greenberg, M.; Harrison, R.J.; Huff, J.; Souza, E.J.; Joshi, T.K.; Kamuzora, P.; Kazan-Allen, L.; Kern, D.G.; Kromhout, H.; Kuswadji, S.; Ladou, J.; Lemen, R.A.; Levenstein, C.; Luethje, B.; Mancini, F.; Meel, B.L.; Mekonnen, Y.; Mendes, R.; Murie, D.; Myers, J.E.; O'Neill, R.; Cisaro, E.; Paek, D.; Richter, E.; Robertson, H.; Rosskam, E.; Samuels, S.W.; Soskolne, C.L.; Stuckey, R.; Teitelbaum, D.T.; Terracini, B.; Thebaud-Mony, A.; Vanhoorne, M.; Wang, X.R.; Watterson, A.; Wedeen, R.

    2006-01-01

    The Finnish Institute of Occupational Health (FIOH) has received support from the World Health Organization (WHO) and the International Labor Office (ILO) to publish the African Newsletter on Occupational Health and Safety. The African Newsletter on Occupational Health and Safety should not be a med

  13. Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses

    DEFF Research Database (Denmark)

    Goltermann, Lise; Sarusie, Menachem V; Bentin, Thomas

    2016-01-01

    Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short-ter...... mechanism for emergence of antibiotic resistance.......Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short......-term tolerance, respectively, to this drug class. Here, we show that chaperonin GroEL/GroES over-expression accelerates acquisition of streptomycin resistance and reduces susceptibility to several other antibiotics following sub-lethal streptomycin antibiotic exposure. Chaperonin buffering could provide a novel...

  14. Chaperonin GroEL/GroES over-expression promotes multi-drug resistance in E. coli following exposure to aminoglycoside antibiotics

    Directory of Open Access Journals (Sweden)

    Lise eGoltermann

    2016-01-01

    Full Text Available Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antiobiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and overexpression sensitize and promote short-term tolerance, respectively, to this drug class. Here we show that chaperonin GroEL/GroES over-expression accelerates acquisition of aminoglycoside resistance and multi-drug resistance following sub-lethal aminoglycoside antibiotic exposure. Chaperonin buffering could provide a novel mechanism for antibiotic resistance and multi-drug resistance development.

  15. Research Today Volume 3, Issue 2 April 2017 Newsletter

    Science.gov (United States)

    2017-05-05

    student and your department has told you they cannot fund your publication, the 59th Clinical Research Division may pay for your basic journal publishing...for your study [ e.g., 59 MDW CRD Graduate Health Sciences Education (GHSE) (SG5 O&M); SG5 R&D; Tri-Service Nursing Research Program (TSNRP); Defense...59crdpubspres@us.af.mil). This should be accomplished no later than 30 days before final clearance Is required to publish/present your materials. If

  16. RESEARCH TODAY VOLUME 3, ISSUE 3 JULY 2017 NEWSLETTER

    Science.gov (United States)

    2017-07-27

    student and your department has told you they cannot fund your publication, the 59th Clinical Research Division may pay for your basic journal...the funding source for your study (e.g., S9 MOW CRD Graduate Health Sciences Education (GHSE) (SGS O&M); SGS R&D: Tri-Service Nursing Research Program...days before final clearance is required to publish/present your materials. If you have any questions or concerns. please contact the 59 CRD

  17. Cloning and characterization of groESL operon in Acetobacter aceti.

    Science.gov (United States)

    Okamoto-Kainuma, Akiko; Yan, Wang; Kadono, Sachiko; Tayama, Kenji; Koizumi, Yukimichi; Yanagida, Fujiharu

    2002-01-01

    The groESL operon of Acetobacter aceti was cloned and sequenced. We observed that GroES and GroEL of A. aceti had high amino acid sequence homologies to GroES and GroEL of Escherichia coli and Bacillus subtilis. The upstream region of the groESL operon contained the heat-shock promoter, which was previously reported in alpha-purple proteobacteria, and the highly conserved inverted repeat sequence. Phylogenetic analysis revealed that the A. aceti GroES and GroEL are very closely related to those of other alpha-purple proteobacteria. Transcription of this operon in A. aceti was induced by heat shock as well as by exposure to ethanol and acetic acid, which are present during fermentation of acetic acid. A. aceti that overexpressed the groESL was more resistant than the control strain to Stressors such as heat, ethanol, or acetic acid, indicating that GroES and GroEL are closely associated with the characteristic nature of Acetobacter and play an important role in acetic acid fermentation.

  18. Mimicking the action of GroEL in molecular dynamics simulations : Application to the refinement of protein structures

    NARCIS (Netherlands)

    Fan, H; Mark, AE

    2006-01-01

    Bacterial chaperonin, GroEL, together with its co-chaperonin, GroES, facilitates the folding of a variety of polypeptides. Experiments suggest that GroEL stimulates protein folding by multiple cycles of binding and release. Misfolded proteins first bind to an exposed hydrophobic surface on GroEL. Gr

  19. The runaway black hole GRO J1655-40

    CERN Document Server

    Mirabel, I F; Rodrigues, I; Combi, J A; Rodríguez, L F; Guglielmetti, F

    2002-01-01

    We have used the Hubble Space Telescope to measure the motion in the sky and compute the galactocentric orbit of the black hole X-ray binary GRO J1655-40. The system moves with a runaway space velocity of $112\\pm 18$ km s$^{-1}$ in a highly eccentric ($e = 0.34\\pm 0.05$) orbit. The black hole was formed in the disk at a distance greater than 3 kpc from the Galactic centre and must have been shot to such an eccentric orbit by the explosion of the progenitor star. The runaway linear momentum and kinetic energy of this black hole binary are comparable to those of solitary neutron stars and millisecond pulsars. GRO J1655-40 is the first black hole for which there is evidence for a runaway motion imparted by a natal kick in a supernova explosion.

  20. NAWIG News: The Quarterly Newsletter of the Native American Wind Interest Group, Fall 2008, Wind & Hydropower Technologies Program (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2008-09-01

    As part of its Native American outreach, DOE?s Wind Powering America program produces a newsletter to present Native American wind information, including projects, interviews with pioneers, issues, WPA activities, and related events. This issue features an interview with Dave Danz, a tribal planner for the Grand Portage Band of Chippewa in northeastern Minnesota, and a feature on the new turbine that powers the KILI radio station on the Pine Ridge Reservation.

  1. New England Wind Forum: A Wind Powering America Project, Newsletter #5 -- January 2010, Wind and Hydropower Technologies Program (WHTP)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, R. C.; Gifford, J.

    2010-01-01

    Wind Powering America program launched the New England Wind Forum (NEWF) in 2005 to provide a single comprehensive source of up-to-date, Web-based information on a broad array of wind energy issues pertaining to New England. The NEWF newsletter provides New England stakeholders with updates on wind energy development in the region. In addition to regional updates, Issue #5 offers an interview with Angus King, former governor of Maine and co-founder of Independence Wind.

  2. Region 4 Inventory and Monitoring Branch Newsletter: Fall 2013

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This I&M newsletter includes highlights of projects in progress or recently completed that contribute to inventory and monitoring initiatives in addition to...

  3. The International Shorebird Surveys, Annual Newsletter March 1982

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Annual newsletter containing the following topics: The Manomet Shorebird Program and ISS; Case Studies; Red Knots and Avocets; News; Survey Sites in the United...

  4. Solar Energy Technologies Program Newsletter - First Quarter 2010

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-04-22

    The first quarter 2010 edition of the Solar Energy Technologies Program newsletter summarizes the activities for the past three months, funding opportunities, highlights from the national labs, and upcoming events.

  5. Region 4 Inventory and Monitoring Branch Newsletter: Spring 2016

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This I&M newsletter includes highlights of projects in progress or recently completed that contribute to inventory and monitoring initiatives in addition to...

  6. Solar Energy Technologies Program Newsletter - Fourth Quarter 2009

    Energy Technology Data Exchange (ETDEWEB)

    DOE Solar Energy Technologies Program

    2009-12-31

    The Fourth Quarter 2009 edition of the Solar Energy Technologies Program newsletter summarizes the activities for the past three months, funding opportunities, highlights from the national labs, and upcoming events.

  7. Eleven Tribes Jump START Clean Energy Projects, Summer 2012 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2012-06-01

    This newsletter describes key activities of the DOE Office of Indian Energy Policy and Programs for Summer 2012. The U.S. Department of Energy Office of Indian Energy Policy and Programs (DOE-IE) has selected 11 Tribes - five in Alaska and six in the contiguous United States - to receive on-the-ground technical support for community-based energy efficiency and renewable energy projects as part of DOE-IE's Strategic Technical Assistance Response Team (START) Program. START finalists were selected based on the clarity of their requests for technical assistance and the ability of START to successfully work with their projects or community. Technical experts from DOE and its National Renewable Energy Laboratory (NREL) will work directly with community-based project teams to analyze local energy issues and assist the Tribes in moving their projects forward. In Alaska, the effort will be bolstered by DOE-IE's partnership with the Denali Commission, which will provide additional assistance and expertise, as well as funding to fuel the Alaska START initiative.

  8. Adding Value to Customers and Developing Brands through Electronic Newsletters

    Directory of Open Access Journals (Sweden)

    Alexandra ZBUCHEA

    2013-12-01

    Full Text Available Online communication is highly efficient for contemporary business, in most market sectors. In this context, companies use several online instruments in order to achieve a wide array of objectives. Among these, online newsletters (e-newsletters are widely used, since they offer a lot of benefits for companies. Since they are flexible in terms of format and content, they are suitable to address a wide variety of publics. Therefore, e-newsletters could be not just informative (as they are widely seen, but also could add-value to customers and support branding processes and relationship development. The present paper investigated various benefits of e-newsletters in this context and highlights some rules to ensure an effective added-value e-newsletter. The research made on the e-newsletters of 5 of the leading publishing-houses in Romania shows that, at least in this market sector, this instrument is not used at its full potential. It is considered in most cases a way to stimulate sales, either directly by announcing sales, or indirectly by announcing new books releases. In some cases news on events and on the activity of the publishing-houses are presenting, leading to image development.

  9. SIMULTANEOUS FITS IN ISIS ON THE EXAMPLE OF GRO J1008–57

    Directory of Open Access Journals (Sweden)

    M. Kühnel

    2015-04-01

    Full Text Available Parallel computing and steadily increasing computation speed have led to a new tool for analyzing multiple datasets and datatypes: fitting several datasets simultaneously.  With this technique, physically connected parameters of individual data can be treated as a single parameter by implementing this connection directly into the fit. We discuss the terminology, implementation, and possible issues of simultaneous fits based on the Interactive Spectral Interpretation System (ISIS X-ray data analysis tool. While all data modeling tools in X-ray astronomy in principle allow data to be fitted individually from multiple data sets, the syntax used in these tools is not often well suited for this task. Applying simultaneous fits to the transient X-ray binary GRO J1008–57, we find that the spectral shape is only dependent on X-ray flux. We determine time independent parameters e.g., the folding energy Efold, with unprecedented precision.

  10. Simultaneous fits in ISIS on the example of GRO J1008-57

    CERN Document Server

    Kühnel, Matthias; Kreykenbohm, Ingo; Schwarm, Fritz-Walter; Grossberger, Christoph; Dauser, Thomas; Pottschmidt, Katja; Ferrigno, Carlo; Rothschild, Richard E; Klochkov, Dmitry; Staubert, Rüdiger; Wilms, Jörn

    2016-01-01

    Parallel computing and steadily increasing computation speed have led to a new tool for analyzing multiple datasets and datatypes: fitting several datasets simultaneously. With this technique, physically connected parameters of individual data can be treated as a single parameter by implementing this connection into the fit directly. We discuss the terminology, implementation, and possible issues of simultaneous fits based on the X-ray data analysis tool Interactive Spectral Interpretation System (ISIS). While all data modeling tools in X-ray astronomy allow in principle fitting data from multiple data sets individually, the syntax used in these tools is not often well suited for this task. Applying simultaneous fits to the transient X-ray binary GRO J1008-57, we find that the spectral shape is only dependent on X-ray flux. We determine time independent parameters such as, e.g., the folding energy E_fold, with unprecedented precision.

  11. Asp-52 in combination with Asp-398 plays a critical role in ATP hydrolysis of chaperonin GroEL.

    Science.gov (United States)

    Koike-Takeshita, Ayumi; Mitsuoka, Kaoru; Taguchi, Hideki

    2014-10-24

    The Escherichia coli chaperonin GroEL is a double-ring chaperone that assists protein folding with the aid of GroES and ATP. Asp-398 in GroEL is known as one of the critical residues on ATP hydrolysis because GroEL(D398A) mutant is deficient in ATP hydrolysis (Asp-52 in the corresponding E. coli GroEL, in addition to Asp-398 is also important for ATP hydrolysis. We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ∼ 20% and Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis. GroEL(D52A/D398A) formed a symmetric football-shaped GroEL-GroES complex in the presence of ATP, again confirming the importance of the symmetric complex during the GroEL ATPase cycle. Notably, the symmetric complex of GroEL(D52A/D398A) was extremely stable, with a half-time of ∼ 150 h (∼ 6 days), providing a good model to characterize the football-shaped complex. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. [Role of GroEL/GroES chaperonin system and Lon protease in regulation of expression Vibrio fischeri lux genes in Escherichia coli cells].

    Science.gov (United States)

    Manukhov, I V; Kotova, V Iu; Zavil'genskiĭ, G B

    2006-01-01

    It was shown that the chaperonin GroEL/GroES and protease Lon influence the expression of the Vibrio fischeri lux regulon in Escherichia coli cells: E. coli groE mutants bearing hybrid plasmid with the lux regulon were weakly luminescent; cells of the E. coli lon- comprising the entire lux regulon display very intense bioluminescence, with no lag period in the induction curve characteristic of lon+ strains. The luxR gene was cloned from the Vibrio fischeri genome in the pGEX-KG vector. It was shown that the active fusion protein GST-LuxR by affinity chromatography on glutathione-sucrose colony is purified only with proteins GroEL and Lon. The present results showed that the LuxR, transcriptional activator of the V. fischeri lux operon, really complexes with GroEL chaperonin and Lon protease. We suppose, that the GroEL/GroES chaperonin systems is required for the folding of LuxR into an active protein, and the LuxR is the target for the ATP-dependent serine Lon protease of E. coli.

  13. Collège de France Newsletter n°8

    OpenAIRE

    (ATER), Benoit Gaultier; (MCF), Jean-Marie Chevalier; Becking, Bob; Berry, Gérard; Berthoz, Prof. Alain; Bréchet, Yves; Bürki, Micaël; Cantera, Alberto; Cazenave, Anny; Changeux, Jean-Pierre; Chatellier, Anne; Chatzivasiliou, Despina; Chu, Steven; Corvol, Prof. Pierre; Cragg, Tony

    2015-01-01

    Published annually since the 2005/2006 academic­ year, the English-language Collège de France Newsletter (formerly The Letter of the Collège de France) is an anthology of translated articles selected from the two or three yearly issues of La Lettre du Collège de France, which was launched in January 2001. Both the French and English publications mirror the life of the institution, its inaugural lectures, lectures and seminars, and include information and announcements relating to the Collège ...

  14. Tannerella forsythia GroEL induces inflammatory bone resorption and synergizes with interleukin-17.

    Science.gov (United States)

    Jung, Y-J; Choi, Y-J; An, S-J; Lee, H-R; Jun, H-K; Choi, B-K

    2016-08-03

    Tannerella forsythia is a major periodontal pathogen, and T. forsythia GroEL is a molecular chaperone homologous to human heat-shock protein 60. Interleukin-17 (IL-17) has been implicated in the pathogenesis of periodontitis and several systemic diseases. This study investigated the potential of T. forsythia GroEL to induce inflammatory bone resorption and examined the cooperative effect of IL-17 and T. forsythia GroEL on inflammatory responses. Human gingival fibroblasts (HGFs) and periodontal ligament (PDL) fibroblasts were stimulated with T. forsythia GroEL and/or IL-17. Gene expression of IL-6, IL-8, and cyclooxygenase-2 (COX-2) and concentrations of IL-6, IL-8, and prostaglandin E2 (PGE2 ) were measured by real-time reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assays, respectively. After stimulation of MG63 cells with T. forsythia GroEL and/or IL-17, gene expression of osteoprotegerin (OPG) was examined. After subcutaneous injection of T. forsythia GroEL and/or IL-17 above the calvaria of BALB/c mice, calvarial bone resorption was assessed by micro-computed tomography and histological examination. Tannerella forsythia GroEL induced IL-6 and IL-8 production in HGFs and PDL cells, and IL-17 further promoted IL-6 and IL-8 production. Both T. forsythia GroEL and IL-17 synergistically increased PGE2 production and inhibited OPG gene expression. Calvarial bone resorption was induced by T. forsythia GroEL injection, and simultaneous injection of T. forsythia GroEL and IL-17 further increased bone resorption. These results suggest that T. forsythia GroEL is a novel virulence factor that can contribute to inflammatory bone resorption caused by T. forsythia and synergizes with IL-17 to exacerbate inflammation and bone resorption.

  15. Pilot trial of an age-paced parenting newsletter.

    Science.gov (United States)

    Keane, Brigid; Waterston, Tony; McConachie, Helen; Towner, Elizabeth; Cook, Margaret; Birks, Eileen

    2005-10-01

    Supporting parents in the first three years of a child's life has the potential to produce successful outcomes. Present government initiatives such as Sure Start focus on this age group. An American educational intervention, in the style of a monthly newsletter, was adapted for use in the UK for parents of young children. Topics were presented in an easy-to-read format and focused on infant emotional development, parent interaction and play. Newsletters, called Baby Express were posted at monthly intervals to the family home providing age-paced information which could meet the specific needs of parents at that stage of their child's life. The aim of the study was to determine the applicability of the newsletter to UK parents and evaluate their satisfaction. Sixty home-based interviews were conducted and 95 per cent of mothers reported reading all or part of the newsletter. Changes in parenting style were spontaneously reported by 28 per cent of mothers. This study found that an aged-paced parenting newsletter was an acceptable and useful method of supporting parents in the early months of a child's life and promotes positive changes in parenting behaviour.

  16. Induction of heat shock proteins DnaK, GroEL, and GroES by salt stress in Lactococcus lactis

    DEFF Research Database (Denmark)

    Kilstrup, Mogens; Jacobsen, Susanne; Hammer, Karin

    1997-01-01

    laboratory strain MG1363, which was originally derived from a dairy strain, After two-dimensional separation of proteins, the DnaK, GroEL, and GroES heat shock proteins, the HrcA (Orf1) heat shack repressor, and the glycolytic enzymes pyruvate kinase, glyceral-dehyde-3-phosphate dehydrogenase......, and phosphoglycerate kinase were identified by a combination of Western blotting and direct N-terminal amino acid sequencing of proteins from the gels, Of 400 to 500 visible proteins, 17 were induced more than twofold during heat stress, Two classes of heat stress proteins were identified from their temporal induction...... proteins exhibited a gradual increase in the rate of synthesis after the onset of stress, Unlike other organisms, all salt stress-induced proteins in L. lactis were also subjected to heat stress induction. DnaK, GroEL, and GroES showed similar temporal patterns of induction during salt stress, resembling...

  17. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid

    DEFF Research Database (Denmark)

    Charbon, Godefroid; Wang, Jiangyun; Brustad, Eric

    2011-01-01

    Escherichia coli cells, indicated colocalization with the cell division protein FtsZ at the cleavage furrow, while a second E. coli study of fixed cells indicated more even distribution throughout the cytoplasm. Here, for the first time, we have examined the spatial distribution of GroEL in living cells using......The molecular chaperone GroEL is required for bacterial growth under all conditions, mediating folding assistance, via its central cavity, to a diverse set of cytosolic proteins; yet the subcellular localization of GroEL remains unresolved. An earlier study, using antibody probing of fixed...... incorporation of a fluorescent unnatural amino acid into the chaperone. Fluorescence microscopy indicated that GroEL is diffusely distributed, both under normal and stress conditions. Importantly, the present procedure uses a small, fluorescent unnatural amino acid to visualize GroEL in vivo, avoiding...

  18. COMPTEL observations of GRO J1655-40

    Science.gov (United States)

    vanDijk, R.; Bennett, K.; Winkler, C.; Bloemen, H.; Hermsen, W.; Diehl, R.; Schoenfelder, V.; McConnell, M.; Ryan, J.

    1997-01-01

    The transient black hole candidate GRO J1655-40 was shown elsewhere to eject matter at apparently superluminal velocities. The oriented scintillation spectrometer experiment (OSSE) spectra, measured during the X-ray outbursts, are consistent with a single power law up to 600 keV, with no evidence of a high energy cutoff. The detection of the flaring behavior of this source up to 10 MeV was claimed elsewhere. The Compton telescope (COMPTEL) observations in the 0.75 to 30 MeV band of this source are analyzed. The upper limits on the time averaged emission are presented and gamma ray flares are searched for. It is concluded that the COMPTEL data can neither confirm nor refute the claimed detection of a large gamma ray flare from this source. The gamma ray flare search in five years' worth of data did not reveal evidence for the occurrence of strong flares on timescales of two days.

  19. "ComPost": A Writing Program Newsletter and Its Rationale.

    Science.gov (United States)

    Hall, Dennis R.

    1993-01-01

    Discusses the development and rationale of "ComPost," a weekly newsletter of the Composition Program at the University of Louisville. Suggests that a vehicle like ComPost can promote the communications that contribute to accomplishing collegiality and genuine program consensus. (RS)

  20. Population Education in Asia and the Pacific Newsletter, Number 23.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    This UNESCO newsletter contains six sections concerned with various aspects of population education. Section 1 deals with workshops for monitoring and evaluating population education programs. Section 2 evaluates the programs of six Asia-Pacific countries (China, Democratic People's Republic of Korea, India, Pakistan, Philippines, and Thailand).…

  1. Using Newsletters to Improve Parents' Communication with Their Early Adolescents

    Science.gov (United States)

    Dworkin, Jodi; Gonzalez, Chris; Gengler, Colleen; Olson, Kathleen

    2011-01-01

    Two sets of newsletters designed to improve parent-teen communication were distributed at two different time points to 71 parents of seventh and eighth graders across five states. At both points, parents completed an evaluation assessing parent-child communication, parenting practices, the emotional experience of parenting, other parent education…

  2. Probing the functional mechanism of Escherichia coli GroEL using circular permutation.

    Directory of Open Access Journals (Sweden)

    Tomohiro Mizobata

    Full Text Available BACKGROUND: The Escherichia coli chaperonin GroEL subunit consists of three domains linked via two hinge regions, and each domain is responsible for a specific role in the functional mechanism. Here, we have used circular permutation to study the structural and functional characteristics of the GroEL subunit. METHODOLOGY/PRINCIPAL FINDINGS: Three soluble, partially active mutants with polypeptide ends relocated into various positions of the apical domain of GroEL were isolated and studied. The basic functional hallmarks of GroEL (ATPase and chaperoning activities were retained in all three mutants. Certain functional characteristics, such as basal ATPase activity and ATPase inhibition by the cochaperonin GroES, differed in the mutants while at the same time, the ability to facilitate the refolding of rhodanese was roughly equal. Stopped-flow fluorescence experiments using a fluorescent variant of the circularly permuted GroEL CP376 revealed that a specific kinetic transition that reflects movements of the apical domain was missing in this mutant. This mutant also displayed several characteristics that suggested that the apical domains were behaving in an uncoordinated fashion. CONCLUSIONS/SIGNIFICANCE: The loss of apical domain coordination and a concomitant decrease in functional ability highlights the importance of certain conformational signals that are relayed through domain interlinks in GroEL. We propose that circular permutation is a very versatile tool to probe chaperonin structure and function.

  3. Testing Age-Paced Parenting Newsletters up to Age 3: Greater Impact on First-Time Parents

    Science.gov (United States)

    Ostergren, Carol S.; Riley, David A.

    2012-01-01

    An age-paced newsletter for parents of toddlers was evaluated. Mothers reported the newsletters were as useful as information from doctors or nurses and more useful than other sources of information. We hypothesized and found that first-time mothers reported the newsletters more useful than experienced mothers--reading more of the newsletters and…

  4. Single-step Purification of Molecular Chaperone GroEL by Expanded Bed Chromatography

    Institute of Scientific and Technical Information of China (English)

    佟晓冬; 杨征; 董晓燕; 孙彦

    2003-01-01

    Expanded bed adsorption (EBA) is an integrative downstream processing technique for the purification of biological substances directly from unclarified feedstock. In this study, molecular chaperone GroEL, an important protein folding helper both in vivo and in vitro, was purified by the single-step EBA technique from the unclarified homogenate of recombinant E. coli cells. Compared with packed bed adsorption, the EBA technique provided a single-step approach to yield an electrophoretic purity of GroEL. After the homogenate loading and column washing in the expanded bed mode, the GroEL protein was recovered by stepwise salt-gradient elution in packed-bed or expanded-bed modes, respectively. The expanded-bed elution mode was found as efficient as the packed-bed mode in the purification of GroEL from cell disruptate.

  5. Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression

    DEFF Research Database (Denmark)

    Laing, Adam F; Lowell, Sally; Brickman, Joshua M

    2015-01-01

    Gro/TLE proteins (TLE1-4) are a family of transcriptional corepressors acting downstream of multiple signalling pathways. Several TLEs are expressed in a dynamic manner throughout embryonic development and at high levels in embryonic stem cells (ESCs). Here we find that Gro/TLE is not required...... in ESC for sustaining pluripotency and suppressing differentiation genes, but rather is important for the shutting down of the pluripotency network in differentiation. Consistent with this view, we found that one of the Gro/TLE family, TLE4 is expressed heterogeneously in ESCs in a population...... that corresponds to a Nanog low subset of ESC culture. TLE4 expression is also increased in response to LIF withdrawal and Fgf/Mek/Erk stimulation. To explore the role of Gro/TLE in more detail we generated an allelic series of knockout ESCs of two TLE genes expressed most dynamically in early differentiation, TLE...

  6. The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements

    Science.gov (United States)

    Bhat, Aadil H.; Pathak, Deepika; Rao, Alka

    2017-01-01

    Threonylcarbamoyladenosine is a universally conserved essential modification of tRNA that ensures translational fidelity in cellular milieu. TsaD, TsaB and TsaE are identified as tRNA-A37-threonylcarbamoyl (t6A)-transferase enzymes that have been reconstituted in vitro, in few bacteria recently. However, transcriptional organization and regulation of these genes are not known in any of these organisms. This study describes the intricate architecture of a complex multicistronic alr-groEL1 operon, harboring essential genes, namely tsaD, tsaB, tsaE, groES, groEL1, and alr (required for cell wall synthesis), and rimI encoding an N-α- acetyltransferase in Mycobacterium tuberculosis. Using northern blotting, RT-PCR and in vivo fluorescence assays, genes alr to groEL1 were found to constitute an ~6.3 kb heptacistronic operon with multiple internal promoters and an I-shaped intrinsic hairpin-like cis-regulatory element. A strong promoter PtsaD within the coding sequence of rimI gene is identified in M. tuberculosis, in addition. The study further proposes an amendment in the known bicistronic groESL1 operon annotation by providing evidence that groESL1 is co-transcribed as sub-operon of alr-groEL1 operon. The architecture of alr-groEL1 operon, conservation of the genetic context and a mosaic transcriptional profile displayed under various stress conditions convincingly suggest the involvement of this operon in stress adaptation in M. tuberculosis. PMID:28256563

  7. Clon of GroEL gene and construction of eukaryotic expression vector in myobacterium tuberclosis%结核分枝杆菌GroEL基因的克隆及真核表达质粒的构建

    Institute of Scientific and Technical Information of China (English)

    付风云; 张卫英

    2009-01-01

    目的 克隆结核分枝杆菌基因组携带的两组GroEL基因,即GroEL1和GroEL2,它们分别编码热休克蛋白HSP60(cpn60.1)和HSP65(cpn60.2),并构建真核表达质粒.方法 用带有EcoR I和Xba I酶切位点的特异性引物,从结核杆菌H37Rv株中PCR扩增两组GroEL基因,构建重组真核表达质粒pCDNA3.1-GroEL1和pCDNA3.1-GroEL2,并进行酶切和测序鉴定.结果 成功克隆了结核分枝杆菌两组GroEL基因,酶切鉴定pCDNA3.1-GroEL1和pCDNA3.1-GroEL2构建成功,经DNA测序证实,载体上插入的序列与GenBank公布的序列一致.结论 获得了结核分枝杆菌GroEL1和GroEL2基因,成功地构建了含GroEL1和GroEL2基因的真核表达质粒,为研究其作为核酸疫苗在免疫学方面作用提供材料.

  8. BeppoSAX observations of GRO J1744-28

    CERN Document Server

    Doroshenko, R; Doroshenko, V; Suleimanov, V; Piraino, S

    2015-01-01

    We present an analysis of BeppoSAX observations of the unique transient bursting X-ray pulsar GRO J1744-28. The observations took place in March 1997 during the decay phase of the outburst. We find that the persistent broadband X-ray continuum of the source is consistent with a cutoff power law typical for the accreting pulsars. We also detect the fluorescence iron line at 6.7 keV and an absorption feature at ~4.5 keV, which we interpret as a cyclotron line. The corresponding magnetic field strength in the line forming region is ~3.7 x 10^11 G. Neither line is detected in the spectra of the bursts. However, additional soft thermal component with kT ~2 keV was required to describe the burst spectrum. We briefly discuss the nature of this component and argue that among other possibilities it might be connected with thermonuclear flashes at the neutron star surface which accompany the accretion-powered bursts in the source.

  9. Atmospheric Radiation Measurement Program Facilities Newsletter - September 1999

    Energy Technology Data Exchange (ETDEWEB)

    Holdridge, D. J., ed

    1999-09-27

    The Atmospheric Radiation Measurement Program September 1999 Facilities Newsletter discusses the several Intensive Observation Periods (IOPs) that the ARM SGP CART site will host in the near future. Two projects of note are the International Pyrgeometer Intercomparison and the Fall Single Column Model (SCM)/Nocturnal Boundary Layer (NBL) IOP. Both projects will bring many US and international scientists to the SGP CART site to participate in atmospheric research.

  10. NAWIG News: The Quarterly Newsletter of the Native American Wind Interest Group, Spring 2008

    Energy Technology Data Exchange (ETDEWEB)

    Baranowski, R.

    2008-03-01

    The United States is home to more than 700 American Indian tribes and Native Alaska villages and corporations located on 96 million acres. Many of these tribes and villages have excellent wind resources that could be commercially developed to meet their electricity needs or for electricity export. The Wind Powering America program engages Native Americans in wind energy development, and as part of that effort, the NAWIG newsletter informs readers of events in the Native American/wind energy community. This issue features an interview with Steven J. Morello, director of DOE's newly formed Office of Indian Energy Policy and Programs, and a feature on the newly installed Vestas V-47 turbine at Turtle Mountain Community College.

  11. Geneletter: An Internet-based newsletter on the ethical, legal, and social implications of genetics. Final report to the Department of Energy [Final report

    Energy Technology Data Exchange (ETDEWEB)

    Reilly, Philip; Wertz, Dorothy C.

    2001-05-01

    The GeneLetter (http://www.geneletter.org) is an Internet newsletter on ethical, legal, and social issues in genetics, designed for a wide and varied audience, some of whom may not be familiar with genetic science. It appears every two months, with a variety of long and short feature articles on ethics and on genetic disorders, a section on new federal and state legislation, an international section, a student corner, book and video reviews, a summary of genetics in the news, and a list of upcoming conferences. Feature articles have ventured into an area of wide general concern, behavioral genetics. The newsletter also has an interactive chatbox and the opportunity of more private communications with the editors via email. The purpose of the GeneLetter is to help fill a communication and knowledge gap on ethical, legal and social issues surrounding genetics.

  12. Technical Assistance Program: Off to a Running Start (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2012-02-01

    This newsletter describes key activities of the DOE Office of Indian Energy Policy and Programs for Winter 2012. Between December 2, 2011, and January 15, 2012, 46 American Indian and Alaska Native Tribes submitted applications to receive technical assistance through the program, which provides Tribes with on-the-ground technical support from DOE and National Renewable Energy Laboratory (NREL) staff to help move tribal energy efficiency and renewable energy projects forward. The applications are being considered through the Strategic Technical Assistance Response Team (START) selection process, which incorporates expert reviews and outreach to Tribes who present a need for assistance with their community-based energy efficiency and renewable energy projects. The final successful applicants will be selected based on the clarity of their requests for technical assistance and the ability of START to successfully work with each unique project or community. At least three selected Tribes in Alaska will receive technical assistance between March and May 2012, and up to five selected Tribes in the contiguous United States will receive technical assistance between March and August 2012. During the months of START Program activity, DOE and NREL experts will work in the two locations. In Alaska, START experts will work directly with community-based project teams to analyze local energy issues and provide assistance with energy projects and cost savings initiatives. This effort will be bolstered by DOE-IE's partnership with the Denali Commission, which will provide further assistance and expertise. In the lower 48 states, NREL experts will work with the selected renewable energy START projects to evaluate financial and technical feasibility and provide early development technical assistance to better position the projects for financing and construction. This on-the-ground technical assistance is part of a broader DOE-IE effort to make reliable, accurate technical

  13. Gro2mat: a package to efficiently read gromacs output in MATLAB.

    Science.gov (United States)

    Dien, Hung; Deane, Charlotte M; Knapp, Bernhard

    2014-07-30

    Molecular dynamics (MD) simulations are a state-of-the-art computational method used to investigate molecular interactions at atomic scale. Interaction processes out of experimental reach can be monitored using MD software, such as Gromacs. Here, we present the gro2mat package that allows fast and easy access to Gromacs output files from Matlab. Gro2mat enables direct parsing of the most common Gromacs output formats including the binary xtc-format. No openly available Matlab parser currently exists for this format. The xtc reader is orders of magnitudes faster than other available pdb/ascii workarounds. Gro2mat is especially useful for scientists with an interest in quick prototyping of new mathematical and statistical approaches for Gromacs trajectory analyses. © 2014 Wiley Periodicals, Inc.

  14. Análise funcional das proteínas HrcA, GroES/GroEL e DnaK/DnaJ em Caulobacter crescentus

    OpenAIRE

    Michelle Fernanda Susin

    2005-01-01

    O operon groESL de C. crescentus apresenta dupla regulação. A indução deste operon por choque térmico é dependente do fator sigma de choque térmico σ32. A temperaturas fisiológicas, a expressão de groESL apresenta regulação temporal durante o ciclo celular da bactéria e o controle envolve a proteína repressora HrcA e o elemento CIRCE (controlling inverted repeat of chaperonin expression). Para estudar a atividade da proteína repressora in vitro, produzimos e purificamos de E. coli a Hrc...

  15. Stereoscopic observations of hard x ray sources in solar flares made with GRO and other spacecraft

    Science.gov (United States)

    Kane, S. R.; Hurley, K.; Mctiernan, J. M.; Laros, J. G.

    1992-01-01

    Since the launch of the Gamma Ray Observatory (GRO) in Apr. 1991, the Burst and Transient Source Experiment (BATSE) instrument on GRO has recorded a large number of solar flares. Some of these flares have also been observed by the Gamma-Ray Burst Detector on the Pioneer Venus Orbiter (PVO) and/or by the Solar X-Ray/Cosmic Gamma-Ray Burst Experiment on the Ulysses spacecraft. A preliminary list of common flares observed during the period May-Jun. 1991 is presented and the possible joint studies are indicated.

  16. Bibliothekarische Berufsethik in der Praxis – Ergebnisse eines Studienprojekts aus Deutschland und Großbritannien

    Directory of Open Access Journals (Sweden)

    Jens Boye

    2011-10-01

    Full Text Available Sowohl in Deutschland als auch in Großbritannien existieren seit einigen Jahren Grundsatzpapiere zur Berufsethik im Informations- und Bibliotheksbereich. Neben der bloßen Existenz derartiger Kodizes stellt sich die Frage, welche Relevanz diese Dokumente in der beruflichen Praxis haben. Dieser Frage wurde im Rahmen einer Team-Projektarbeit an der FH Köln nachgegangen. Mithilfe eines standardisierten Fragebogens wurden deutsche Bibliotheksleitungen zu der Thematik befragt. In Großbritannien wurde ein Interview mit Paul Sturges geführt, darüber hinaus erfolgte eine Analyse der Online-Angebote von CILIP, insbesondere des Information Ethics Blog.

  17. LBRIG Newsletter (Newsletter of the Language by Radio Interest Group). Vol. 4, No. 2.

    Science.gov (United States)

    Garfinkel, Alan, Ed.; And Others

    One new French course taught by short wave radio is described here, and the remainder of the issue is devoted to schedules of major language programs (French, Spanish, Russian, German and Hebrew) given on short wave radio in North America. Frequencies are given in kilohertz, wavebands in meters. Approximate reception quality under normal…

  18. Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats.

    Directory of Open Access Journals (Sweden)

    Feng-Yen Lin

    Full Text Available Porphyromonas gingivalis is a major periodontal pathogen that contains a variety of virulence factors. The antibody titer to P. gingivalis GroEL, a homologue of HSP60, is significantly higher in periodontitis patients than in healthy control subjects, suggesting that P. gingivalis GroEL is a potential stimulator of periodontal disease. However, the specific role of GroEL in periodontal disease remains unclear. Here, we investigated the effect of P. gingivalis GroEL on human periodontal ligament (PDL cells in vitro, as well as its effect on alveolar bone resorption in rats in vivo. First, we found that stimulation of PDL cells with recombinant GroEL increased the secretion of the bone resorption-associated cytokines interleukin (IL-6 and IL-8, potentially via NF-κB activation. Furthermore, GroEL could effectively stimulate PDL cell migration, possibly through activation of integrin α1 and α2 mRNA expression as well as cytoskeletal reorganization. Additionally, GroEL may be involved in osteoclastogenesis via receptor activator of nuclear factor κ-B ligand (RANKL activation and alkaline phosphatase (ALP mRNA inhibition in PDL cells. Finally, we inoculated GroEL into rat gingiva, and the results of microcomputed tomography (micro-CT and histomorphometric assays indicated that the administration of GroEL significantly increased inflammation and bone loss. In conclusion, P. gingivalis GroEL may act as a potent virulence factor, contributing to osteoclastogenesis of PDL cells and resulting in periodontal disease with alveolar bone resorption.

  19. GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function.

    Directory of Open Access Journals (Sweden)

    Yi-Wen Lin

    Full Text Available The number and function of endothelial progenitor cells (EPCs are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. GroEL1 from Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis. However, the actual effects of GroEL1 on EPC function are unclear. In this study, we investigate the EPC function in GroEL1-administered hind limb-ischemic C57BL/B6 and C57BL/10ScNJ (a toll-like receptor 4 (TLR4 mutation mice and human EPCs. In mice, laser Doppler imaging, flow cytometry, and immunohistochemistry were used to evaluate the degree of neo-vasculogenesis, circulating level of EPCs, and expression of CD34, vWF, and endothelial nitric oxide synthase (eNOS in vessels. Blood flow in the ischemic limb was significantly impaired in C57BL/B6 but not C57BL/10ScNJ mice treated with GroEL1. Circulating EPCs were also decreased after GroEL1 administration in C57BL/B6 mice. Additionally, GroEL1 inhibited the expression of CD34 and eNOS in C57BL/B6 ischemic muscle. In vitro, GroEL1 impaired the capacity of differentiation, mobilization, tube formation, and migration of EPCs. GroEL1 increased senescence, which was mediated by caspases, p38 MAPK, and ERK1/2 signaling in EPCs. Furthermore, GroEL1 decreased integrin and E-selectin expression and induced inflammatory responses in EPCs. In conclusion, these findings suggest that TLR4 and impaired NO-related mechanisms could contribute to the reduced number and functional activity of EPCs in the presence of GroEL1 from C. pneumoniae.

  20. Further observations of GRO J1750-27 (AXJ1749.1-2639) with INTEGRAL

    DEFF Research Database (Denmark)

    Brandt, Søren Kristian; Shaw, S.; Hill, A.;

    2008-01-01

    The transient accreting X-ray pulsar GRO J1750-27 (AX J1749.1-2639), which became active end of January 2008 (ATel #1376), has been repeatedly observed by the INTEGRAL Galactic Bulge monitoring program since mid February (ATel #1385) on 11, 20 and 23 Feb. 2008. During the three observations...

  1. Rapidly evolving circularly polarized emission during the 1994 outburst of GRO J1655-40

    NARCIS (Netherlands)

    Macquart, JP; Wu, K; Sault, RJ; Hannikainen, DC

    2002-01-01

    We report the detection of circular polarization during the 1994 outburst of the Galactic microquasar GRO J1655-40. The circular polarization is clearly detected at 1.4 and 2.4 GHz, but not at 4.8 and 8.4 GHz, where its magnitude never exceeds 5 mJy. Both the sign and magnitude of the circular

  2. Positive selection in the leucine-rich repeat domain of Gro1 genes in Solanum species

    Indian Academy of Sciences (India)

    Valentino Ruggieri; Angelina Nunziata; Amalia Barone

    2014-12-01

    In pathogen resistant plants, solvent-exposed residues in the leucine-rich repeat (LRR) proteins are thought to mediate resistance by recognizing plant pathogen elicitors. In potato, the gene Gro1-4 confers resistance to Globodera rostochiensis. The investigation of variablity in different copies of this gene represents a good model for the verification of positive selection mechanisms. Two datasets of Gro1 LRR sequences were constructed, one derived from the Gro1-4 gene, belonging to different cultivated and wild Solanum species, and the other belonging to paralogues of a resistant genotype. Analysis of non-synonymous to synonymous substitution rates $(K_{a}/K_{s})$ highlighted 14 and six amino acids with $K_{a}/K_{s} \\gt 1$ in orthologue and paralogue datasets, respectively. Selection analysis revealed that the leucine-rich regions accumulate variability in a very specific way, and we found that some combinations of amino acids in these sites might be involved in pathogen recognition. The results confirm previous studies on positive selection in the LRR domain of R protein in Arabidopsis and other model plants and extend these to wild Solanum species. Moreover, positively selected sites in the Gro1 LRR domain show that coevolution mainly occurred in two regions on the internal surface of the three-dimensional horseshoe structure of the domain, albeit with different evolutionary forces between paralogues and orthologues.

  3. The Accretion Powered Spin-up of GRO 1750–27

    DEFF Research Database (Denmark)

    Kretschmar, P.; Shaw, S.; Hill, A. B.

    2009-01-01

    The transient Be X-ray pulsar GRO J1750-27 was originally detected in 1995 by CGRO/BATSE during a giant outburst. After a long period of quiescence the source was detected in another outburst early 2008. Following this outburst with hard X-ray data from INTEGRAL and Swift, the orbital parameters ...

  4. The accretion powered spin-up of GRO J1750-27

    DEFF Research Database (Denmark)

    Shaw, S.E.; Hill, A.B.; Kuulkers, E.

    2009-01-01

    ), respectively. The model is then used to compare the time-resolved variation of the X-ray flux and intrinsic spin-up against the accretion torque model of Ghosh & Lamb; this finds that GRO J1750-27 is likely located 12-22 kpc distant and that the surface magnetic field of the neutron star is similar to 2 x 10...

  5. Computational Approaches for Mining GRO-Seq Data to Identify and Characterize Active Enhancers.

    Science.gov (United States)

    Nagari, Anusha; Murakami, Shino; Malladi, Venkat S; Kraus, W Lee

    2017-01-01

    Transcriptional enhancers are DNA regulatory elements that are bound by transcription factors and act to positively regulate the expression of nearby or distally located target genes. Enhancers have many features that have been discovered using genomic analyses. Recent studies have shown that active enhancers recruit RNA polymerase II (Pol II) and are transcribed, producing enhancer RNAs (eRNAs). GRO-seq, a method for identifying the location and orientation of all actively transcribing RNA polymerases across the genome, is a powerful approach for monitoring nascent enhancer transcription. Furthermore, the unique pattern of enhancer transcription can be used to identify enhancers in the absence of any information about the underlying transcription factors. Here, we describe the computational approaches required to identify and analyze active enhancers using GRO-seq data, including data pre-processing, alignment, and transcript calling. In addition, we describe protocols and computational pipelines for mining GRO-seq data to identify active enhancers, as well as known transcription factor binding sites that are transcribed. Furthermore, we discuss approaches for integrating GRO-seq-based enhancer data with other genomic data, including target gene expression and function. Finally, we describe molecular biology assays that can be used to confirm and explore further the function of enhancers that have been identified using genomic assays. Together, these approaches should allow the user to identify and explore the features and biological functions of new cell type-specific enhancers.

  6. Over expression of GroESL in Cupriavidus necator for heterotrophic and autotrophic isopropanol production.

    Science.gov (United States)

    Marc, Jillian; Grousseau, Estelle; Lombard, Eric; Sinskey, Anthony J; Gorret, Nathalie; Guillouet, Stéphane E

    2017-07-01

    We previously reported a metabolic engineering strategy to develop an isopropanol producing strain of Cupriavidus necator leading to production of 3.4gL(-1) isopropanol. In order to reach higher titers, isopropanol toxicity to the cells has to be considered. A toxic effect of isopropanol on the growth of C. necator has been indeed observed above a critical value of 15gL(-1). GroESL chaperones were first searched and identified in the genome of C. necator. Native groEL and groES genes from C. necator were over-expressed in a strain deleted for PHA synthesis. We demonstrated that over-expressing groESL genes led to a better tolerance of the strain towards exogenous isopropanol. GroESL genes were then over-expressed within the best engineered isopropanol producing strain. A final isopropanol concentration of 9.8gL(-1) was achieved in fed-batch culture on fructose as the sole carbon source (equivalent to 16gL(-1) after taking into account evaporation). Cell viability was slightly improved by the chaperone over-expression, particularly at the end of the fermentation when the isopropanol concentration was the highest. Moreover, the strain over-expressing the chaperones showed higher enzyme activity levels of the 2 heterologous enzymes (acetoacetate carboxylase and alcohol dehydrogenase) of the isopropanol synthetic operon, translating to a higher specific production rate of isopropanol at the expense of the specific production rate of acetone. Over-expressing the native chaperones led to a 9-18% increase in the isopropanol yield on fructose. Copyright © 2017 International Metabolic Engineering Society. All rights reserved.

  7. Effective enhancement of Pseudomonas stutzeri D-phenylglycine aminotransferase functional expression in Pichia pastoris by co-expressing Escherichia coli GroEL-GroES

    Directory of Open Access Journals (Sweden)

    Jariyachawalid Kanidtha

    2012-04-01

    Full Text Available Abstract Background D-phenylglycine aminotransferase (D-PhgAT of Pseudomonas stutzeri ST-201 catalyzes the reversible stereo-inverting transamination potentially useful in the application for synthesis of D-phenylglycine and D-4-hydroxyphenylglycine using L-glutamate as a low cost amino donor substrate in one single step. The enzyme is a relatively hydrophobic homodimeric intracellular protein difficult to express in the soluble functionally active form. Over-expression of the dpgA gene in E. coli resulted in the majority of the D-PhgAT aggregated into insoluble inclusion bodies that failed to be re-natured. Expression in Pichia pastoris was explored as an alternative route for high level production of the D-PhgAT. Results Intracellular expression of the codon-optimized synthetic dpgA gene under the PAOX1 promoter in P. pastoris resulted in inactive D-PhgAT associated with insoluble cellular fraction and very low level of D-PhgAT activity in the soluble fraction. Manipulation of culture conditions such as addition of sorbitol to induce intracellular accumulation of osmolytes, addition of benzyl alcohol to induce chaperone expression, or lowering incubation temperature to slow down protein expression and folding rates all failed to increase the active D-PhgAT yield. Co-expression of E. coli chaperonins GroEL-GroES with the D-PhgAT dramatically improved the soluble active enzyme production. Increasing gene dosage of both the dpgA and those of the chaperones further increased functional D-PhgAT yield up to 14400-fold higher than when the dpgA was expressed alone. Optimization of cultivation condition further increased D-PhgAT activity yield from the best co-expressing strain by 1.2-fold. Conclusions This is the first report on the use of bacterial chaperones co-expressions to enhance functional intracellular expression of bacterial enzyme in P. pastoris. Only two bacterial chaperone genes groEL and groES were sufficient for dramatic enhancement of

  8. 利用膨胀床吸附技术单步纯化分子伴侣—GroEL%Single-step Purification of Molecular Chaperone GroEL by Expanded Bed Chromatography

    Institute of Scientific and Technical Information of China (English)

    佟晓冬; 杨征; 董晓燕; 孙彦

    2003-01-01

    Expanded bed adsorption (EBA) is an integrative downstream processing technique for the purificationof biological substances directly from unclarified feedstock. In this study, molecular chaperone GroEL, an importantprotein folding helper both in vivo and in vitro, was purified by the single-step EBA technique from the unclarifiedhomogenate of recombinant E. coli cells. Compared with packed bed adsorption, the EBA technique provideda single-step approach to yield an electrophoretic purity of GroEL. After the homogenate loading and columnwashing in the expanded bed mode, the GroEL protein was recovered by stepwise salt-gradient elution in packed-bed or expanded-bed modes, respectively. The expanded-bed elution mode was found as efficient as the packed-bedmode in the purification of GroEL from cell disruptate.

  9. Induction of heat shock proteins DnaK, GroEL, and GroES by salt stress in Lactococcus lactis

    DEFF Research Database (Denmark)

    Kilstrup, Mogens; Jacobsen, Susanne; Hammer, Karin;

    1997-01-01

    The bacterium Lactococcus lactis has become a model organism in studies of growth physiology and membrane transport, as a result of its simple fermentative metabolism. It is also used as a model for studying the importance of specific genes and functions during lie in excess nutrients, by compari......The bacterium Lactococcus lactis has become a model organism in studies of growth physiology and membrane transport, as a result of its simple fermentative metabolism. It is also used as a model for studying the importance of specific genes and functions during lie in excess nutrients......, by comparison of prototrophic wild-type strains and auxotrophic domesticated (daily) strains. In a study of the capacity of domesticated strains to perform directed responses toward various stress conditions, we have analyzed the heat and salt stress response in the established L,. lactis subsp. cremoris...... laboratory strain MG1363, which was originally derived from a dairy strain, After two-dimensional separation of proteins, the DnaK, GroEL, and GroES heat shock proteins, the HrcA (Orf1) heat shack repressor, and the glycolytic enzymes pyruvate kinase, glyceral-dehyde-3-phosphate dehydrogenase...

  10. Perturbation-based Markovian transmission model for probing allosteric dynamics of large macromolecular assembling: a study of GroEL-GroES.

    Directory of Open Access Journals (Sweden)

    Hsiao-Mei Lu

    2009-10-01

    Full Text Available Large macromolecular assemblies are often important for biological processes in cells. Allosteric communications between different parts of these molecular machines play critical roles in cellular signaling. Although studies of the topology and fluctuation dynamics of coarse-grained residue networks can yield important insights, they do not provide characterization of the time-dependent dynamic behavior of these macromolecular assemblies. Here we develop a novel approach called Perturbation-based Markovian Transmission (PMT model to study globally the dynamic responses of the macromolecular assemblies. By monitoring simultaneous responses of all residues (>8,000 across many (>6 decades of time spanning from the initial perturbation until reaching equilibrium using a Krylov subspace projection method, we show that this approach can yield rich information. With criteria based on quantitative measurements of relaxation half-time, flow amplitude change, and oscillation dynamics, this approach can identify pivot residues that are important for macromolecular movement, messenger residues that are key to signal mediating, and anchor residues important for binding interactions. Based on a detailed analysis of the GroEL-GroES chaperone system, we found that our predictions have an accuracy of 71-84% judged by independent experimental studies reported in the literature. This approach is general and can be applied to other large macromolecular machineries such as the virus capsid and ribosomal complex.

  11. Luminosity dependent accretion state change in GRO J1008–57

    Directory of Open Access Journals (Sweden)

    Kühnel Matthias

    2014-01-01

    Full Text Available In a former publication, we have analyzed the transient neutron star X-ray binary GRO J1008–57 using all available RXTE-, Swift-, and Suzaku-data. As we have found, the source’s spectral components, i.e., a power-law with high exponential cutoff and a black-body, are strongly correlated with the hard X-ray flux (15–50 keV. We update the analytical description of these dependence, including a change in the photon index behaviour from a flat to a logarithmic function. The flux, where the change occurs, is consistent with the onset of the black-body emission. Thus, a change of the accretion state always occurs in GRO J1008–57 at a particular flux level.

  12. Adsorption of a model protein, the GroEL chaperonin, on surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Leung, Carl; Palmer, Richard E [Nanoscale Physics Research Laboratory, School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)], E-mail: carl.leung@kcl.ac.uk

    2008-09-03

    Understanding and controlling protein adsorption on surfaces is fundamental to many biological processes ranging from cell adhesion to the fabrication of protein biochips. In general, proteins need to retain their 3D conformation to perform their intended functions. However, when they are presented with a solid surface, complex interactions ranging from weak non-covalent binding to strong covalent bonding may occur, which can potentially induce conformational changes within the adsorbed protein. To investigate the surface adsorption process and its effects on a model protein, the chaperonin GroEL, we have applied contact mode atomic force microscopy, in buffer solution to probe the interactions between single proteins and surfaces in real space. We will discuss the adsorption of GroEL molecules on planar surfaces (mica, graphite and gold) and specifically tailored nanostructured surfaces, which present structural features on the size scale of individual biological molecules. (topical review)

  13. Thermonuclear Burning on the Accreting X-Ray Pulsar GRO J1744-28

    CERN Document Server

    Bildsten, L; Bildsten, Lars; Brown, Edward F.

    1996-01-01

    We investigate the thermal stability of nuclear burning on the accreting X-ray pulsar GRO J1744-28. The neutron star's dipolar magnetic field is 50 years. We also discuss the nature of the binary and point out that a velocity measurement of the stellar companion (most likely a Roche-lobe filling giant with m_K>17) will constrain the neutron star mass.

  14. INTEGRAL/XMM views on the MeV source GRO J1411-64

    CERN Document Server

    Torres, D F; Reimer, O; Barcons, X; Corral, A; Bosch-Ramon, V; Paredes, J M; Romero, G E; Qu, J L; Collmar, W; Schönfelder, V; Butt, Y; Torres, Diego F.; Zhang, Shu; Reimer, Olaf; Barcons, Xavier; Corral, Amalia; Bosch-Ramon, Valent\\'{\\i}; Paredes, Josep M.; Romero, Gustavo E.; Qu, Jin Lu; Collmar, Werner; Sch\\"onfelder, Volker; Butt, Yousaf

    2006-01-01

    The COMPTEL unidentified source GRO J 1411-64 was observed by INTEGRAL and XMM-Newton in 2005. The Circinus Galaxy is the only source detected within the 4$\\sigma$ location error of GRO J1411-64, but in here excluded as the possible counterpart. At soft X-rays, 22 reliable and statistically significant sources (likelihood $> 10$) were extracted and analyzed from XMM-Newton data. Only one of these sources, XMMU J141255.6 -635932, is spectrally compatible with GRO J1411-64 although the fact the soft X-ray observations do not cover the full extent of the COMPTEL source position uncertainty make an association hard to quantify and thus risky. At the best location of the source, detections at hard X-rays show only upper limits, which, together with MeV results obtained by COMPTEL suggest the existence of a peak in power output located somewhere between 300-700 keV for the so-called low state. Such a spectrum resembles those in blazars or microquasars, and might suggest at work by a similar scenario. However, an an...

  15. Temporal Variations And Spectral Properties of Be/X-ray Pulsar GRO J1008-57 Studied by INTEGRAL

    CERN Document Server

    Wang, Wei

    2013-01-01

    Spin period variations and hard X-ray spectral properties of Be/X-ray pulsar GRO J1008-57 are studied with INTEGRAL observations. The pulsation periods at 93.66 s in 2004 and at 93.73 s in 2009 are determined. Pulse profiles of GRO J1008-57 during outbursts are energy dependent: double-peak profile in soft bands of 3-7 keV and single-peak profile in hard X-rays above 7 keV. GRO J1008-57 has undergone a spin-down trend from 1993-2009 with a rate of 4.1x10^-5 s day^-1, and might transfer into a spin-up trend after 2009. The spectra from 3-100 keV of GRO J1008-57 during outbursts are fitted with photon index of 1.4 and cutoff energies of 23-29 keV. We find a relatively soft spectrum in early phase of the 2009 outburst with cutoff energy 13 keV. Above a hard X-ray flux of 10^-9 erg cm^-2 s^-1, the spectra of GRO J1008-57 during outbursts need an enhanced hydrogen absorption of column density 6x10^22 cm^-2. The observed dip-like pulse profile of GRO J1008-57 in soft X-ray bands should be caused by this intrinsic a...

  16. Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR

    Science.gov (United States)

    Libich, David S.; Tugarinov, Vitali; Clore, G. Marius

    2015-01-01

    The prototypical chaperonin GroEL assists protein folding through an ATP-dependent encapsulation mechanism. The details of how GroEL folds proteins remain elusive, particularly because encapsulation is not an absolute requirement for successful re/folding. Here we make use of a metastable model protein substrate, comprising a triple mutant of Fyn SH3, to directly demonstrate, by simultaneous analysis of three complementary NMR-based relaxation experiments (lifetime line broadening, dark state exchange saturation transfer, and Carr–Purcell–Meinboom–Gill relaxation dispersion), that apo GroEL accelerates the overall interconversion rate between the native state and a well-defined folding intermediate by about 20-fold, under conditions where the “invisible” GroEL-bound states have occupancies below 1%. This is largely achieved through a 500-fold acceleration in the folded-to-intermediate transition of the protein substrate. Catalysis is modulated by a kinetic deuterium isotope effect that reduces the overall interconversion rate between the GroEL-bound species by about 3-fold, indicative of a significant hydrophobic contribution. The location of the GroEL binding site on the folding intermediate, mapped from 15N, 1HN, and 13Cmethyl relaxation dispersion experiments, is composed of a prominent, surface-exposed hydrophobic patch. PMID:26124125

  17. Astronomy Career Profiles from the AAS Newsletter Archives

    CERN Document Server

    Metcalfe, Travis; McDaid, Liam; Bullock, Blake; Pulliam, Christine; Williams, Peter; Roth, Joshua; Whitney, Barb; Olsen, Knut; Howell, Andy; Keller, Luke

    2011-01-01

    This is a collection of articles that were originally published in the Newsletter of the American Astronomical Society (AAS) between May 2008 and September 2011 by the Committee on Employment. Authors representing a wide range of career paths tell their stories and provide insight and advice that is relevant to success in various job sectors. Although all of these articles are available individually from the AAS archives, we are posting the complete collection here to make them more accessible as a resource for the astronomy community. The collection includes the following articles: (1) Changing Priorities: the Hard Money Wild Card, (2) Beyond Ivory Towers, (3) Astronomers Working in Public Outreach, (4) Bush-Whacking a Career Trail, (5) Science Communication as a Press Officer, (6) Jobs in Industry, (7) Back to School: A Ph.D. Enters the Classroom, (8) Working at a Soft-Money Institute, (9) Balancing Research and Service at NOAO, (10) Succeeding in a Large Research Collaboration, and (11) Preparing for the C...

  18. Increased expression and purification of soluble iron-regulatory protein 1 from Escherichia coli co-expressing chaperonins GroES and GroEL

    Directory of Open Access Journals (Sweden)

    H. Carvalho

    2008-04-01

    Full Text Available Iron is an essential metal for all living organisms. However, iron homeostasis needs to be tightly controlled since iron can mediate the production of reactive oxygen species, which can damage cell components and compromise the integrity and/or cause DNA mutations, ultimately leading to cancer. In eukaryotes, iron-regulatory protein 1 (IRP1 plays a central role in the control of intracellular iron homeostasis. This occurs by interaction of IRP1 with iron-responsive element regions at 5' of ferritin mRNA and 3' of transferrin mRNA which, respectively, represses translation and increases mRNA stability. We have expressed IRP1 using the plasmid pT7-His-hIRP1, which codifies for human IRP1 attached to an NH2-terminal 6-His tag. IRP1 was expressed in Escherichia coli using the strategy of co-expressing chaperonins GroES and GroEL, in order to circumvent inclusion body formation and increase the yield of soluble protein. The protein co-expressed with these chaperonins was obtained mostly in the soluble form, which greatly increased the efficiency of protein purification. Metal affinity and FPLC ion exchange chromatography were used in order to obtain highly purified IRP1. Purified protein was biologically active, as assessed by electrophoretic mobility shift assay, and could be converted to the cytoplasmic aconitase form. These results corroborate previous studies, which suggest the use of folding catalysts as a powerful strategy to increase protein solubility when expressing heterologous proteins in E. coli.

  19. GroEL to DnaK chaperone network behind the stability modulation of σ(32) at physiological temperature in Escherichia coli.

    Science.gov (United States)

    Patra, Monobesh; Roy, Sourav Singha; Dasgupta, Rakhi; Basu, Tarakdas

    2015-12-21

    The stability of heat-shock transcription factor σ(32) in Escherichia coli has long been known to be modulated only by its own transcribed chaperone DnaK. Very few reports suggest a role for another heat-shock chaperone, GroEL, for maintenance of cellular σ(32) level. The present study demonstrates in vivo physical association between GroEL and σ(32) in E. coli at physiological temperature. This study further reveals that neither DnaK nor GroEL singly can modulate σ(32) stability in vivo; there is an ordered network between them, where GroEL acts upstream of DnaK.

  20. Effects of the chaperonin GroE on the refolding of tryptophanase from Escherichia coli. Refolding is enhanced in the presence of ADP.

    Science.gov (United States)

    Mizobata, T; Akiyama, Y; Ito, K; Yumoto, N; Kawata, Y

    1992-09-01

    The refolding of the tetrameric enzyme tryptophanase was facilitated by the chaperonin GroE. Maximum refolding yield of tryptophanase molecules (about 80%) was attained in the presence of a 15-fold excess of GroE 21-mer over tryptophanase monomer. The GroEL subunit was required for this improvement in refolding yield, whereas the GroES subunit was not. Light scattering experiments of the refolding reaction revealed that GroE bound to tryptophanase folding intermediates and suppressed their aggregation. The presence of ATP was required for the efficient dissociation of tryptophanase from GroEL. However, our experiments indicated that tryptophanase dissociated readily from GroEL in the presence of not only ATP, but also in the presence of non-hydrolyzable ATP analogues such as ATP gamma S (adenosine 5'-O-(3-thiotriphosphate)) and AMP-PNP (adenyl-5'-yl imidodiphosphate) as well. Surprisingly, the release of tryptophanase from GroEL was facilitated in the presence of ADP as well. We concluded that the binding of nucleotides such as ATP and ADP changed the conformation of GroEL and facilitated the dissociation of tryptophanase molecules. The conformation formed in the presence of ADP was distinct from the conformation formed in the presence of ATP, as shown by the selective dissociation of various folding proteins from the two conformations.

  1. An insecticidal GroEL protein with chitin binding activity from Xenorhabdus nematophila.

    Science.gov (United States)

    Joshi, Mohan Chandra; Sharma, Animesh; Kant, Sashi; Birah, Ajanta; Gupta, Gorakh Prasad; Khan, Sharik R; Bhatnagar, Rakesh; Banerjee, Nirupama

    2008-10-17

    Xenorhabdus nematophila secretes insecticidal proteins to kill its larval prey. We have isolated an approximately 58-kDa GroEL homolog, secreted in the culture medium through outer membrane vesicles. The protein was orally insecticidal to the major crop pest Helicoverpa armigera with an LC50 of approximately 3.6 microg/g diet. For optimal insecticidal activity all three domains of the protein, apical, intermediate, and equatorial, were necessary. The apical domain alone was able to bind to the larval gut membranes and manifest low level insecticidal activity. At equimolar concentrations, the apical domain contained approximately one-third and the apical-intermediate domain approximately one-half bioactivity of that of the full-length protein. Interaction of the protein with the larval gut membrane was specifically inhibited by N-acetylglucosamine and chito-oligosaccharides. Treatment of the larval gut membranes with chitinase abolished protein binding. Based on the three-dimensional structural model, mutational analysis demonstrated that surface-exposed residues Thr-347 and Ser-356 in the apical domain were crucial for both binding to the gut epithelium and insecticidal activity. Double mutant T347A,S356A was 80% less toxic (p activity with Kd approximately 0.64 microm and Bmax approximately 4.68 micromol/g chitin. The variation in chitin binding activity of the mutant proteins was in good agreement with membrane binding characteristics and insecticidal activity. The less toxic double mutant XnGroEL showed an approximately 8-fold increase of Kd in chitin binding assay. Our results demonstrate that X. nematophila secretes an insecticidal GroEL protein with chitin binding activity.

  2. Food Safety. Nourishing News. Volume 3, Issue 10

    Science.gov (United States)

    Idaho State Department of Education, 2009

    2009-01-01

    Serving safe food is a critical responsibility for maintaining quality foodservice programs and healthy environments at schools and child care facilities. Child Nutrition Programs hopes you find this newsletter of assistance when reviewing the food safety program you have at each serving site. The articles contained in this issue are: (1) A…

  3. Marine Corps Center for Lessons Learned Newsletter. Volume 9, Issue 01, January 2013

    Science.gov (United States)

    2013-01-01

    Corps was “a veritable witches’ brew of racism and discrimination.” But LtGen Krulak went further than he had to, essentially disavowing his...466-3193 DSN: (312) 582-3193 2d MLG, Camp Lejeune, NC (910) 451-6924 DSN: (312) 751-6924 III MEF & 1st MAW Okinawa, Japan DSN: (315) 622-9218 3d...MARDIV & 3d MLG Okinawa, Japan DSN: (315) 622-7358 Hawaii Marines Kaneohe Bay, Hawaii (808) 257-5939 DSN: (315) 257-5939 MARFORRES, 4th MAW & 4th MLG New

  4. Warfighter Effectiveness Research Center Biannual Newsletter. Volume 1, Issue1, December 2014

    Science.gov (United States)

    2014-12-01

    concussions ,” said LCDR Brian Johnson. It was this unique military-academic status that led the NCAA and Department of De- fense to include USAFA as a...health information should they be concussed,” said LCDR John- son. “They also give researchers like us a more accurate picture of concussions at...In the Media http://www.usafa.af.mil/news/story.asp?id=123420140 Making an ‘ImPACT’: USAFA works to mitigate concussions http://www.usafa.af.mil

  5. Warfighter Effectiveness Research Center Biannual Newsletter. Volume 1, Issue 2, June 2015

    Science.gov (United States)

    2015-06-01

    place to study concussions ,” said LCDR Bri- an Johnson. It was this unique military -academic sta- tus that led the NCAA and De- partment of...researchers like us a more accurate picture of concussions at USAFA.” The USAFA concussion research team. From left to right: LtCol Jon Jackson (10th

  6. Fight’s On! Newsletter. Volume 8, Issue 1, Spring 2009

    Science.gov (United States)

    2009-06-01

    Prepare for Red Flag; Kleinlein, B., Testbed Upgrade for Helmet-Mounted Cueing System; Symons , S., Dynamic Motion Seat Undergoes Fidelity Assessment...fast jet simulation environ- ments for training. Lt Col Steven Symons , 711 HPW/RHA, and Dr. Winston Bennett, 711 HPW/RHAS 711 HPW/RHA Technology

  7. Human Social Culture Behavior Modeling Program Newsletter. Volume 1. Issue 1, Spring 2009

    Science.gov (United States)

    2009-03-30

    the social psychol- ogy of consumer behavior . A key theory in this space is the Theory of Reasoned Action (TRA), which hypothesizes the re...useful in predicting a range of consumer behavior , including the effectiveness of anti-smoking cam- paigns and weight loss programs—each of which...Priester, J.R. (2002). The social psychology of consumer behavior . Buckingham, UK: Open University Press. Ajzen, I. & Fishbein, M. (1980

  8. INTEGRAL and XMM-Newton observations towards the unidentified MeV source GRO J1411-64

    CERN Document Server

    Torres, D F; Reimer, O; Barcons, X; Corral, A; Bosch-Ramon, V; Paredes, J M; Romero, G E; Qu, J L; Collmar, W; Schönfelder, V; Butt, Y; Torres, Diego F.; Zhang, Shu; Reimer, Olaf; Barcons, Xavier; Corral, Amalia; Bosch-Ramon, Valenti; Paredes, Josep M.; Romero, Gustavo E.; Qu, Jin Lu; Collmar, Werner; Butt, Yousaf

    2006-01-01

    The COMPTEL unidentified source GRO J1411-64 was observed by INTEGRAL, and its central part, also by XMM-Newton. The data analysis shows no hint for new detections at hard X-rays. The upper limits in flux herein presented constrain the energy spectrum of whatever was producing GRO J1411-64, imposing, in the framework of earlier COMPTEL observations, the existence of a peak in power output located somewhere between 300-700 keV for the so-called low state. The Circinus Galaxy is the only source detected within the 4$\\sigma$ location error of GRO J1411-64, but can be safely excluded as the possible counterpart: the extrapolation of the energy spectrum is well below the one for GRO J1411-64 at MeV energies. 22 significant sources (likelihood $> 10$) were extracted and analyzed from XMM-Newton data. Only one of these sources, XMMU J141255.6-635932, is spectrally compatible with GRO J1411-64 although the fact the soft X-ray observations do not cover the full extent of the COMPTEL source position uncertainty make an...

  9. Eine CarSharing-Zielgruppenanalyse der großen SrV-Vergleichsstädte

    OpenAIRE

    Hahn, Christoph

    2015-01-01

    Due to enormous growth rates during the last couple of years CarSharing has become an interesting field of research. This Master Thesis focuses on the analysis of CarSharing users. For this purpose more than 37.000 participants of the "Große SrV-Vergleichsstädte"-Survey were taken into account. After a short literature review and some general information about the statistical methods, the thesis tries to work out some major characteristics of the typical CarSharing user. It will be shown, tha...

  10. Geopressure industrial forums, newsletter and lease support. Final report, April 7, 1981-December 31, 1983

    Energy Technology Data Exchange (ETDEWEB)

    Knutson, C.F.

    1983-12-01

    In the course of this contract C. K. GeoEnergy: (1) planned, organized, conducted, and reported on six DOE/Industry Forum meetings where the progress of DOE's resource development program was outlined and discussed (these six forum meetings included three meetings of the Drilling and Testing Subgroup and three meetings of the Overview Group), (2) prepared and distributed 15 newsletters, and (3) prepared three reports for DOE lease support. This final report includes summaries of each of the forum meetings as well as the three lease support meetings and the newsletter program.

  11. NuSTAR Observations of the Be/X-ray Binary GRO J1008-57 in Outburst

    Science.gov (United States)

    Bellm, Eric; Fuerst, F.; Pottschmidt, K.; Wilms, J.; Boggs, S. E.; Christensen, F.; Craig, W. W.; Hailey, C. J.; Harrison, F.; Stern, D.; Tomsick, J.; Zhang, W.; NuSTAR Science Team

    2013-04-01

    GRO J1008-57 is an HMXB that exhibits regular outbursts due to orbitally-driven accretion onto the neutron star from the Be companion. Spectral analysis of previous bursts have suggested the existence of a cyclotron resonant scattering feature at 88 keV, which, if confirmed as the fundamental line, would indicate the presence of one of the most highly-magnetized accreting neutron stars. In November 2012, GRO J1008 produced a Type II ("giant") burst with peak flux near 1 Crab. NuSTAR observed the outburst for 12 ksec near the peak of emission. We present spectral and timing analysis of GRO J1008 over NuSTAR's 3-79 keV energy band. Considering that the putative 88 keV line could be a harmonic rather than the fundamental, we search for cyclotron lines in the NuSTAR band and discuss implications for models of the system's magnetic field.

  12. Confirmation of a high magnetic field in GRO J1008–57

    Energy Technology Data Exchange (ETDEWEB)

    Bellm, Eric C.; Fürst, Felix; Harrison, Fiona A.; Walton, Dominic J. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Pottschmidt, Katja [Center for Space Science and Technology, University of Maryland Baltimore County, Baltimore, MD 21250 (United States); Tomsick, John A.; Boggs, Steven E.; Craig, William W. [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Chakrabarty, Deepto [Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Christensen, Finn E. [DTU Space-National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Hailey, Charles J. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Stern, Daniel [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Wilms, Jörn [Dr. Karl-Remeis-Sternwarte and ECAP, Sternwartstr. 7, D-96049 Bamberg (Germany); Zhang, William W., E-mail: ebellm@caltech.edu [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2014-09-10

    GRO J1008–57 is a high-mass X-ray binary for which several claims of a cyclotron resonance scattering feature near 80 keV have been reported. We use NuSTAR, Suzaku, and Swift data from its giant outburst of 2012 November to confirm the existence of the 80 keV feature and perform the most sensitive search to date for cyclotron scattering features at lower energies. We find evidence for a 78{sub −2}{sup +3} keV line in the NuSTAR and Suzaku data at >4σ significance, confirming the detection using Suzaku alone by Yamamoto et al. A search of both the phase-averaged and phase-resolved data rules out a fundamental at lower energies with optical depth larger than 5% of the 78 keV line. These results indicate that GRO J1008–57 has a magnetic field of 6.7 × 10{sup 12}(1 + z) G, the highest among known accreting pulsars.

  13. Let's Talk About You and Sharks, American Oceanography Special Educational Newsletter.

    Science.gov (United States)

    Kraft, Thomas L.; Miloy, Leatha

    1971-01-01

    This special educational newsletter of the American Society for Oceanography presents information on marine oriented subjects, primarily for reading by junior high and secondary school students. Major articles consider the habits and stinging effects of sharks, jelly fish, and sting rays, and what one should do if stung by these fish while…

  14. Newsletters: An Effective Delivery Mode for Providing Educational Information and Emotional Support to Single Parent Families?

    Science.gov (United States)

    Nelson, Patricia Tanner

    1986-01-01

    Suggests that newsletters can be an effective method of education and support for some single parents. In questionnaires and telephone interviews completed with 27 percent of the readers who received "Solo Parenting" for one year, respondents reported attitude and behavior changes without the benefit of face-to-face meetings. (Author/BL)

  15. [SMEAC Newsletters, Science Education, Vol. 1, No. 1--Vol. 2, No. 1, 1967-1968].

    Science.gov (United States)

    ERIC Clearinghouse for Science, Mathematics, and Environmental Education, Columbus, OH.

    Each of these newsletters, produced by the ERIC Information Analysis Center for Science, Mathematics, and Environmental Education, contains information concerning center publications and other items considered of interest to researchers and educators of various education levels. Vol. 1, No. 1 highlights selected bibliographies (no longer produced…

  16. [SMEAC Newsletters, Science Education, Vol. 2, No. 2--Vol. 2, No. 3, 1969].

    Science.gov (United States)

    ERIC Clearinghouse for Science, Mathematics, and Environmental Education, Columbus, OH.

    Each of these newsletters, produced by the ERIC Information Analysis Center for Science, Mathematics, and Environmental Education, Contains information concerning center publications and activities, as well as other items considered of interest to researchers and educators of various educational levels. One of the emphases in Vol. 2, No. 2, is a…

  17. CVRP Patch Panel; The Newsletter of the California Video Resource Project.

    Science.gov (United States)

    Lourea, Lee Oliver, Ed.

    1975-01-01

    The bimonthly newsletter of the California Video Resource Project reports on the Children's Television Fair sponsored by the Committee for Children's Television and other groups, and on other activities. A demonstration of light used as a television art form is also described, and employees of the CVRP are profiled. The facilities and hardware of…

  18. The Newsletter as a Communication Medium in Teaching Low-Income Homemakers.

    Science.gov (United States)

    Ben Efionayi, Joseph Aibangbee

    The objectives of this study were to determine the sources from which low-income families generally receive information about nutrition, to determine the extent to which the participants acquired knowledge of nutrition principles as taught through a newsletter, and also to find out their attitude towards the publication as a medium of nutritional…

  19. Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.

    OpenAIRE

    Mizushima, T.; Matsuo, M.; Sekimizu, K

    1997-01-01

    Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to those required for DNA relaxation and much higher than those required for cell death.

  20. Predominant recognition of species-specific determinants of the GroES homologues from Mycobacterium leprae and M. tuberculosis

    NARCIS (Netherlands)

    Chua-Intra, B.; Ivanyi, J.; Hills, A.; Thole, J.; Moreno, C.; Vordermeier, H.M.

    1998-01-01

    The Mycobacterium leprae and M. tuberculosis 10000 MW heat-shock protein homologues of GroES have previously been identified as major immunogens for human T cells. We used synthetic peptides to characterize the determinants recognized by murine T cells. The findings suggest that, despite 90% sequenc

  1. Simultaneous NuSTAR/Chandra Observations of The Bursting Pulsar GRO J1744-28 During Its Third Reactivation

    DEFF Research Database (Denmark)

    Younes, G.; Kouveliotou, C.; Grefenstette, B. W.

    2015-01-01

    We report on a 10 ks simultaneous Chandra/High Energy Transmission Grating (HETG)-Nuclear Spectroscopic Telescope Array (NuSTAR) observation of the Bursting Pulsar, GRO J1744-28, during its third detected outburst since discovery and after nearly 18 yr of quiescence. The source is detected up to ...

  2. Assessing Reliability and Validity of the "GroPromo" Audit Tool for Evaluation of Grocery Store Marketing and Promotional Environments

    Science.gov (United States)

    Kerr, Jacqueline; Sallis, James F.; Bromby, Erica; Glanz, Karen

    2012-01-01

    Objective: To evaluate reliability and validity of a new tool for assessing the placement and promotional environment in grocery stores. Methods: Trained observers used the "GroPromo" instrument in 40 stores to code the placement of 7 products in 9 locations within a store, along with other promotional characteristics. To test construct validity,…

  3. Discovery of a non-blazar $\\gamma$-ray transient near the Galactic plane GRO J1838-04

    CERN Document Server

    Tavani, M; Mattox, J R; Halpern, J; Thompson, D J; Kanbach, G; Hermsen, W; Zhang, S N; Foster, R S

    1997-01-01

    We report the discovery of a remarkable gamma-ray transient source near the Galactic plane, GRO J1838-04. This source was serendipitously discovered by EGRET in June 1995 with a peak intensity of 4 E(-6) ph/cm/cm/s (for photon energies larger than 100 MeV) and a 5.9 sigma significance. At that time, GRO J1838-04 was the second brightest gamma-ray source in the sky. A subsequent EGRET pointing in late September 1995 detected the source at a flux smaller than its peak value by a factor of 7. We determined that no radio-loud spectrally-flat blazar is within the error box of GRO J1838-04. We discuss the origin of the \\ggg-ray transient source and show that interpretations in terms of AGNs or isolated pulsars are highly problematic. GRO J1838-04 provides strong evidence for the existence of a new class of variable gamma-ray sources.

  4. Effects of the prebiotics GroBiotic-A and inulin on the intestinal microbiota of red drum, Sciaenops ocellatus

    Science.gov (United States)

    Two separate feeding trials examined the effects of dietary supplementation of the prebiotics GroBiotic®-A and inulin on growth performance and gastrointestinal tract microbiota of the red drum Sciaenops ocellatus. In the first feeding trial, fishmeal-based diets without prebiotics or supplemented ...

  5. Senate Rostrum: Academic Senate for California Community Colleges Newsletter

    Science.gov (United States)

    Academic Senate for California Community Colleges, 2010

    2010-01-01

    The Rostrum is a quarterly publication of the Academic Senate for California Community Colleges. The following articles are included in this issue: (1) The Need for full Time faculty (again) by Jane Patton; (2) Reading May Be the Key to Unlocking Basic Skills Success by Janet Fulks; (3) Diversity Institute on the Right Track by Beth Smith; (4)…

  6. Schoolhouse. A Newsletter from Educational Facilities Laboratories. No. 26.

    Science.gov (United States)

    Educational Facilities Labs., Inc., New York, NY.

    This issue addresses the question frequently asked by administrators, "Is solar energy suitable for new or existing schools?" Various applications of solar energy that schools have installed or are about to install are described. These examples include a new school designed for solar energy, an existing school with solar energy added, a simple…

  7. Paul Scherrer Institut annual report 1995. Annex II: PSI life sciences and institute for medical radiobiology newsletter 1995

    Energy Technology Data Exchange (ETDEWEB)

    Blaeuenstein, P.; Gschwend, B. [eds.

    1996-09-01

    The newsletter presents the 1995 progress report of PSI F2-Department and of the Institute for Medical Radiobiology in the fields of radiation medicine, radiopharmacy and radiation hygiene. figs., tabs., refs.

  8. The effectiveness of personalized e-mail newsletters and the role of personal characteristics.

    Science.gov (United States)

    Maslowska, Ewa; Putte, Bas van den; Smit, Edith G

    2011-12-01

    Personalizing communication means creating persuasive messages that refer to aspects of a person's self. Although the use of personalization is increasing, research on its effectiveness is limited and the results are mixed. This study examined the persuasiveness of personalized e-mail newsletters in terms of increased attention, cognitive activity, evaluation, attitude, intention, and behavior by means of an experiment (n=109). Participants randomly received either a personalized or a generic newsletter advertising a sports center. Personalization triggered a more positive evaluation of the message; however, it did not influence the other effect variables. The effects were moderated by consumers' need for uniqueness, trust, and privacy concerns, suggesting that personalization is a good strategy to increase message evaluation only among individuals who have a high need for uniqueness.

  9. Abstracts of the 28. annual meeting of the Austrian Radiation Oncology, Radiation Biology and Medical Radiation Physics Society (OeGRO 2011); Abstracts der 28. Jahrestagung der Oesterreichischen Gesellschaft fuer Radioonkologie, Radiobiologie und Medizinische Radiophysik (OeGRO 2011)

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2012-06-15

    The second part of the volume includes the abstracts of the 28th annual meeting of the Austrian Radiation Oncology, Radiation Biology and Medical Radiation Physics Society (OeGRO 2011), covering the following topics: extracranial stereotactic radiotherapy; brachytherapy, hyperthermia; radiotherapy side effects; psycho-oncology in radiotherapy; head-neck carcinomas; radiation source implants for carcinoma irradiation; MRI-supported adaptive radiotherapy; CT-guided radiotherapy; mammary carcinomas; prostate carcinomas; magnetic nanoparticles for future medical applications.

  10. The lesional skin of linear IgA bullous dermatosis expresses growth-regulated peptide (GRO)-alpha.

    Science.gov (United States)

    Tsunemi, Yuichiro; Ihn, Hironobu; Saeki, Hidehisa; Tamaki, Kunihiko

    2004-07-01

    The patient was a 62-year-old man with erythema with tense vesiculobullae and erosions on the bilateral elbows, right knee, and one buttock. A skin biopsy specimen revealed subepidermal blister formation with a predominant infiltration of neutrophils and papillary neutrophilic microabscesses. Direct immunofluorescence study showed linear deposition of IgA and weak deposition of IgG at the basement membrane zone of the lesional skin, and indirect immunofluorescence study showed linear deposition of IgA at the epidermal side of the 1M NaCl-separated normal skin. He was diagnosed with linear IgA bullous dermatosis. Immunohistochemical study revealed that the lesional and perilesional keratinocytes expressed growth-regulated peptide (GRO) -alpha, a potent chemoattractant for neutrophils. This suggests that GRO-alpha plays a role in the infiltration of neutrophils into the lesional skin and in bulla formation in linear IgA bullous dermatosis.

  11. GRO J1655-40: Early Stages of the 2005 Outburst

    CERN Document Server

    Shaposhnikov, N; Shrader, C R; Rupen, M; Beckmann, V; Markwardt, C B; Smith, D A

    2006-01-01

    The black-hole X-ray binary transient GRO J1655-40 underwent an outburst beginning in early 2005. We present the results of our multi-wavelength observational campaign to study the early outburst spectral and temporal evolution, which combines data from X-ray (RXTE, INTEGRAL), radio (VLA) and optical (ROTSE, SMARTS) instruments. During the reported period the source left quiescence and went through four major accreting black hole states: low-hard, hard intermediate, soft intermediate and high-soft. We investigated dipping behavior in the RXTE band and compare our results to the 1996-1997 case, when the source was predominantly in the high-soft state, finding significant differences. We consider the evolution of the low frequency quasi-periodic oscillations and find that the frequency strongly correlates with the spectral characteristics, before shutting off prior to the transition to the high-soft state. We model the broad-band high-energy spectrum in the context of empirical models, as well as more physicall...

  12. Allosteric transitions of supramolecular systems explored by network models: application to chaperonin GroEL.

    Directory of Open Access Journals (Sweden)

    Zheng Yang

    2009-04-01

    Full Text Available Identification of pathways involved in the structural transitions of biomolecular systems is often complicated by the transient nature of the conformations visited across energy barriers and the multiplicity of paths accessible in the multidimensional energy landscape. This task becomes even more challenging in exploring molecular systems on the order of megadaltons. Coarse-grained models that lend themselves to analytical solutions appear to be the only possible means of approaching such cases. Motivated by the utility of elastic network models for describing the collective dynamics of biomolecular systems and by the growing theoretical and experimental evidence in support of the intrinsic accessibility of functional substates, we introduce a new method, adaptive anisotropic network model (aANM, for exploring functional transitions. Application to bacterial chaperonin GroEL and comparisons with experimental data, results from action minimization algorithm, and previous simulations support the utility of aANM as a computationally efficient, yet physically plausible, tool for unraveling potential transition pathways sampled by large complexes/assemblies. An important outcome is the assessment of the critical inter-residue interactions formed/broken near the transition state(s, most of which involve conserved residues.

  13. The quiescent light curve and orbital period of GRO$\\sim$J0422+32

    CERN Document Server

    Chevalier, C; Chevalier, Claude; Ilovaisky, Sergio A

    1996-01-01

    CCD photometry of the black hole candidate GRO~J0422+32 in quiescence, obtained at Haute-Provence from 1994 November to 1995 February, reveals a double-wave modulation at a period close to the value we found during outbursts and also close to one of the possible periods derived by Filippenko, Matheson and Ho (1995) from spectroscopic observations with the W. M. Keck 10-m telescope. A period of 0.212140 \\pm 0.000003 d (5.09136 \\pm 0.00007 h) fits all our photometric data from 1993 January to 1995 February and yields a minimum in our light curves at the inferior conjunction of the M star, as determined from the radial velocity data of Filippenko et al. (1995). The quiescent R_{c} band light curve exhibits a changing asymmetry of shape and a variable amplitude. On two consecutive nights the source was found constant to within \\pm 0.05 mag, suggesting an upper limit on the ellipsoidal effect in this band.

  14. Vanadyl ions binding to GroEL (HSP60) and inducing its depolymerization

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Several vanadium compounds have been known for the hypoglycemic and anticancer effects. However, the mechanisms of the pharmacological and toxicological effects were not clear. In this work, we investigated the potential targets of vanadium in mitochondria. Vanadyl ions were found to bind to mitochondria from rat liver with a stoichiometry of 244±58 nmol/mg protein and an apparent dissocia- tion constant (Kd) of (2.0±0.8)×10-16 mol/L. Using size exclusion chromatography, a vanadium-binding protein was isolated and identified to be the 60-kDa heat shock protein (HSP60) by mass spectrometry analysis and immunoassays. Additionally, binding of vanadyl ions was found to result in depolymerization of homo-oligomeric HSP60 (GroEL). HSP60 is an indispensable molecular chaperone and involved in many kinds of pathogenesis of inflammatory and autoimmune diseases, e.g. type 1 diabetes. Our results suggested that HSP60 could be a novel important target involved in the biological and/or toxicological effects of vanadium compounds.

  15. Spectral and Timing evolution of GRO J1655-40 during its outburst of 2005

    CERN Document Server

    Debnath, D; Nandi, A; Mandal, S

    2009-01-01

    In a recent outburst which lasted for 260 days, the black hole candidate GRO J1655-40 exhibited a behaviour similar to its last outburst observed almost eight years ago. We analyze a total of 150 observational spells in 122 days of data spreaded over the entire outburst phase of Feb. 2005 to Oct. 2005. From our study, a comprehensive understanding of the detailed behaviour of this black hole candidate has emerged. Based on the degree of importance of the black body and the power-law components we divide the entire episode in four spectral states, namely, hard, soft, very soft and intermediate. Quasi-Periodic oscillations (QPOs) were found in two out of these four states, namely, in the hard and the intermediate states. In the hard state, at the rising phase of the outburst, QPO frequency ranged from 0.034 - 17.78Hz and the spectra was fitted by a disk black body, power-law and iron emission line at 6.2 - 6.5 keV. In the intermediate state, QPOs vary from 13.17Hz to 19.04Hz and the QPO frequency modulation in ...

  16. High-Resolution X-Ray Spectroscopy of the Bursting Pulsar GRO J1744-28

    CERN Document Server

    Degenaar, N; Harrison, F A; Kennea, J A; Kouveliotou, C; Younes, G

    2014-01-01

    The bursting pulsar GRO J1744-28 is a Galactic low-mass X-ray binary that distinguishes itself by displaying type-II X-ray bursts: brief, bright flashes of X-ray emission that likely arise from spasmodic accretion. Combined with its coherent 2.1 Hz X-ray pulsations and relatively high estimated magnetic field, it is a particularly interesting source to study the physics of accretion flows around neutron stars. Here we report on Chandra/HETG observations obtained near the peak of its bright 2014 accretion outburst. Spectral analysis suggests the presence of a broad iron emission line centered at E_l ~ 6.7 keV. Fits with a disk reflection model yield an inclination angle of i ~ 52 degrees and an inner disk radius of R_in ~ 85 GM/c^2, which is much further out than typically found for neutron star low-mass X-ray binaries. Assuming that the disk is truncated at the magnetospheric radius of the neutron star, we estimate a magnetic field strength of B ~ (2-6)E10 G. Furthermore, we identify an absorption feature nea...

  17. A Super-Eddington Compton-Thick Wind in GRO J1655-40?

    CERN Document Server

    Neilsen, J; Homan, J; Buxton, M

    2016-01-01

    During its 2005 outburst, GRO J1655-40 was observed at high spectral resolution with the Chandra HETGS, revealing a spectrum rich with blueshifted absorption lines indicative of an accretion disk wind -- apparently too hot, too dense, and too close to the black hole to be driven by radiation pressure or thermal pressure (Miller et al.). But this exotic wind represents just one piece of the puzzle in this outburst, as its presence coincides with an extremely soft and curved X-ray continuum spectrum, remarkable X-ray variability (Uttley & Klein-Wolt), and a bright, unexpected optical/infrared blackbody component that varies on the orbital period. Focusing on the X-ray continuum and the optical/infrared/UV spectral energy distribution, we argue that the unusual features of this "hypersoft state" are natural consequences of a super-Eddington Compton-thick wind from the disk: the optical/infrared blackbody represents the cool photosphere of a dense, extended outflow, while the X-ray emission is explained as Co...

  18. 表达大肠杆菌分子伴侣GroEL、 GroES和GrpE载体的构建及其应用%Construction of the Vector Expressing GroEL 、 GroES and GrpE from Escherchia coli and Its Application

    Institute of Scientific and Technical Information of China (English)

    许鹏; 王蕾蕾; 程备久; 范军

    2012-01-01

    Coexpression system in Escherichia coli often requires the different plasmids with different antibiotic resistance genes and replicons. Using sticky-end PCR cloning technology, two independent,PCR reactions were performed for amplifying the artificial operon from pR-GESP plasmid, which contains the artificial polycistron of GroEL, GroES and GrpE genes from E. coli encoding three molecular chaperones. The cohesive end of the PCR products allowed to be inserted into pACYCDuet-1 plasmid treated with Ncol and Xhol. The constructed plasmid named pA-GESP contained the artificial operon, pl5A replicon and chloramphenicol resistance gene, compatible with pET-28b plasmid including ColEl replicon and kanamycin resistance gene. The SDS-PAGE analysis showed that three chaperones were expressed in soluble form from the induced E. coli cells carrying pA-GESP plasmid, similar to the cells harboring pR-GESP plasmid. Co-expression of three molecular chaperones partly improved the soluble expression of recombinant maize serine racemase, but did not have an affect on the expression of maize ferrodioxin reductase. Co-expression of three molecular chaperones, yeast 5-aminolevulinate synthase and Bacillus subtilis uroporphyrinogen methyltransferase from three plasmids containing the different antibiotics resistance gene increased the accumulation of intracellular red fluorescent products catalyzed by two enzymes successively. The production was estimated about 562. 13 ±3. 17/OD600 , compared with the production of 457. 66 ±4. 98/OD600 without function of the recombinant chaperones. The results suggested three chaperones partly improved the soluble expression of some proteins and catalytic activity in E. coli.%大肠杆菌(Escherichia coli)共表达系统常要求质粒具有不同抗生素抗性以及不同的复制子.利用粘性末端PCR技术,以含有大肠杆菌分子伴侣基因GroEL、GroES和GrpE的pR-GESP质粒为模板,设计两对引物,通

  19. Multiplex PCR for the detection and differentiation of Vibrio parahaemolyticus strains using the groEL, tdh and trh genes.

    Science.gov (United States)

    Hossain, Muhammad Tofazzal; Kim, Young-Ok; Kong, In-Soo

    2013-01-01

    Vibrio parahaemolyticus is a significant cause of human gastrointestinal disorders worldwide, transmitted primarily by ingestion of raw or undercooked contaminated seafood. In this study, a multiplex PCR assay for the detection and differentiation of V. parahaemolyticus strains was developed using primer sets for a species-specific marker, groEL, and two virulence markers, tdh and trh. Multiplex PCR conditions were standardised, and extracted genomic DNA of 70 V. parahaemolyticus strains was used for identification. The sensitivity and efficacy of this method were validated using artificially inoculated shellfish and seawater. The expected sizes of amplicons were 510 bp, 382 bp, and 171 bp for groEL, tdh and trh, respectively. PCR products were sufficiently different in size, and the detection limits of the multiplex PCR for groEL, tdh and trh were each 200 pg DNA. Specific detection and differentiation of virulent from non-virulent strains in shellfish homogenates and seawater was also possible after artificial inoculation with various V. parahaemolyticus strains. This newly developed multiplex PCR is a rapid assay for detection and differentiation of pathogenic V. parahaemolyticus strains, and could be used to prevent disease outbreaks and protect public health by helping the seafood industry maintain a safe shellfish supply.

  20. TELESCAN. Volume 4, Issues 1-10, September 1984-June 1985.

    Science.gov (United States)

    TELESCAN, 1985

    1985-01-01

    A digest about how higher education can use new telecommunications technologies, especially to reach students in off-campus settings, is presented. Ten issues of volume 4 of the newsletter "TELESCAN" include information on legislation and trends in the applications of technology-based instruction in postsecondary education. Also included are…

  1. Making a friend from a foe: expressing a GroEL gene from the whitefly Bemisia tabaci in the phloem of tomato plants confers resistance to tomato yellow leaf curl virus.

    Science.gov (United States)

    Akad, F; Eybishtz, A; Edelbaum, D; Gorovits, R; Dar-Issa, O; Iraki, N; Czosnek, H

    2007-01-01

    Some (perhaps all) plant viruses transmitted in a circulative manner by their insect vectors avoid destruction in the haemolymph by interacting with GroEL homologues, ensuring transmission. We have previously shown that the phloem-limited begomovirus tomato yellow leaf curl virus (TYLCV) interacts in vivo and in vitro with GroEL produced by the whitefly vector Bemisia tabaci. In this study, we have exploited this phenomenon to generate transgenic tomato plants expressing the whitefly GroEL in their phloem. We postulated that following inoculation, TYLCV particles will be trapped by GroEL in the plant phloem, thereby inhibiting virus replication and movement, thereby rendering the plants resistant. A whitefly GroEL gene was cloned in an Agrobacterium vector under the control of an Arabidopsis phloem-specific promoter, which was used to transform two tomato genotypes. During three consecutive generations, plants expressing GroEL exhibited mild or no disease symptoms upon whitefly-mediated inoculation of TYLCV. In vitro assays indicated that the sap of resistant plants contained GroEL-TYLCV complexes. Infected resistant plants served as virus source for whitefly-mediated transmission as effectively as infected non-transgenic tomato. Non-transgenic susceptible tomato plants grafted on resistant GroEL-transgenic scions remained susceptible, although GroEL translocated into the grafted plant and GroEL-TYLCV complexes were detected in the grafted tissues.

  2. CcpA affects expression of the groESL and dnaK operons in Lactobacillus plantarum

    Directory of Open Access Journals (Sweden)

    Marasco Rosangela

    2006-11-01

    Full Text Available Abstract Background Lactic acid bacteria (LAB are widely used in food industry and their growth performance is important for the quality of the fermented product. During industrial processes changes in temperature may represent an environmental stress to be overcome by starters and non-starters LAB. Studies on adaptation to heat shock have shown the involvement of the chaperon system-proteins in various Gram-positive bacteria. The corresponding operons, namely the dnaK and groESL operons, are controlled by a negative mechanism involving the HrcA repressor protein binding to the cis acting element CIRCE. Results We studied adaptation to heat shock in the lactic acid bacterium Lactobacillus plantarum. The LM3-2 strain, carrying a null mutation in the ccpA gene, encoding the catabolite control protein A (CcpA, showed a lower percent of survival to high temperature with respect to the LM3 wild type strain. Among proteins differentially expressed in the two strains, the GroES chaperon was more abundant in the wild type strain compared to the mutant strain under standard growth conditions. Transcriptional studies showed that class I heat shock operons were differentially expressed upon heat shock in both strains. Indeed, the dnaK and groESL operons were induced about two times more in the LM3 strain compared to the LM3-2 strain. Analysis of the regulatory region of the two operons showed the presence of cre sequences, putative binding sites for the CcpA protein. Conclusion The L. plantarum dnaK and groESL operons are characterized by the presence of the cis acting sequence CIRCE in the promoter region, suggesting a negative regulation by the HrcA/CIRCE system, which is a common type of control among the class I heat shock operons of Gram-positive bacteria. We found an additional system of regulation, based on a positive control exerted by the CcpA protein, which would interact with cre sequences present in the regulatory region of the dnaK and gro

  3. Gene cloning and expression analysis of Gro/KC by primary hepatocytes

    Directory of Open Access Journals (Sweden)

    GH. Hassanshahi

    2007-01-01

    Full Text Available Abstract Background and purpose: It is now well established that several environmental stresses lead to activation of p38 MAP kinase and JNK in various cell systems which is followed by chemokine producion. We investigated the expression of both CXC chemokines SDF-1a (ELR- and Gro/KC (ELR+ in rat H4 hepatoma cells in response to heat shock, hyper-osmolarity and oxidative stresses. The pattern of expression of these chemokines by hepatoma cells in response to stress conditions was also studied.Materials and Methods: Hepatoma cells were maintained in MEM medium. Cells were subjected to different stresses [(H2O2 0.15% (w/v, manitol and NaCl (160 mM and heat shock [(42 °C for 20 minutes]. At the indicated time points, cells were harvested and RNA was extracted, purified and expression of the chemokines were analysed by RT-PCR. cDNA was separated by gel electrophoresis on a 1% (w/v agarose gel and visualised on a UV transilluminator.Results: Results obtained in this report showed that there was detectable but low expression of chemokines in H4 hepatoma cells. Heat shock failed to induce expression of chemokines in H4 rat hepatoma cells. Hyper-osmolarity also has not stimulated Chemokines expression. In this study we have also shown that oxidative stress did not induce expression of chemokines. Overall, although detection is possible but regulatory responses were not observed in H4 hepatoma cells.Conclusion: Several known injurious conditions cause recruitment of macrophages, neutrophils and other immune cells to the liver. Immune cells are recruited to the hepatic vasculature following local liver injury and consequent chemokine production. Our results demonstrated that failure in production of these chemokines by Hepatoma cells may be a way to escape from immune surveillance.

  4. HIGH-RESOLUTION X-RAY SPECTROSCOPY OF THE BURSTING PULSAR GRO J1744-28

    Energy Technology Data Exchange (ETDEWEB)

    Degenaar, N.; Miller, J. M. [Department of Astronomy, University of Michigan, 1085 South University Avenue, Ann Arbor, MI 48109 (United States); Harrison, F. A. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Kennea, J. A. [Department of Astronomy and Astrophysics, 525 Davey Lab, Pennsylvania State University, University Park, PA 16802 (United States); Kouveliotou, C. [Space Science Office, ZP12, NASA Marshall Space Flight Center, Huntsville, AL 35812 (United States); Younes, G., E-mail: degenaar@umich.edu [Universities Space Research Association, 6767 Old Madison Pike, Suite 450, Huntsville, AL 35806 (United States)

    2014-11-20

    The bursting pulsar GRO J1744-28 is a Galactic low-mass X-ray binary that distinguishes itself by displaying type-II X-ray bursts: brief, bright flashes of X-ray emission that likely arise from spasmodic accretion. Combined with its coherent 2.1 Hz X-ray pulsations and relatively high estimated magnetic field, it is a particularly interesting source to study the physics of accretion flows around neutron stars. Here we report on Chandra/High Energy Transmission Grating observations obtained near the peak of its bright 2014 accretion outburst. Spectral analysis suggests the presence of a broad iron emission line centered at E {sub l} ≅ 6.7 keV. Fits with a disk reflection model yield an inclination angle of i ≅ 52° and an inner disk radius of R {sub in} ≅ 85 GM/c {sup 2}, which is much further out than typically found for neutron star low-mass X-ray binaries. Assuming that the disk is truncated at the magnetospheric radius of the neutron star, we estimate a magnetic field strength of B ≅ (2-6) × 10{sup 10} G. Furthermore, we identify an absorption feature near ≅ 6.85 keV that could correspond to blue-shifted Fe XXV and point to a fast disk wind with an outflow velocity of v {sub out} ≅ (7.5-8.2) × 10{sup 3} km s{sup –1} (≅ 0.025c-0.027c). If the covering fraction and filling factor are large, this wind could be energetically important and perhaps account for the fact that the companion star lost significant mass while the magnetic field of the neutron star remained strong.

  5. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 19, Number 4, July-August 2006

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2006-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  6. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 16, Number 6. November-December 2003

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Jensen, Susan, Ed.; Lucich, Mardi, Ed.

    2003-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  7. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 19, Number 1. January-February 2006

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Gendell, Mara, Ed.

    2006-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  8. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 23, Number 1, January-February 2010

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2010-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  9. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 16, Number 2. March-April 2003

    Science.gov (United States)

    Zamani, Rahman, Ed.; Guralnick, Eva, Ed.; Kunitz, Judith Ed.

    2003-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  10. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 21, Number 1. January-February 2008

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Turner, Debra, Ed.

    2008-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  11. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 19, Number 6, November-December 2006

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2006-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of this newsletter are to promote and support a healthy and safe environment…

  12. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 20, Number 3, May-June 2007

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2007-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  13. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 17, Number 5. September-October 2004

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Lucich, Mardi, Ed.; Walsh, Eileen, Ed.

    2004-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  14. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 16, Number 3. May-June 2003

    Science.gov (United States)

    Zamani, Rahman, Ed.; Guralnick, Eva, Ed.; Kunitz, Judith, Ed.

    2003-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  15. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 21, Number 6. November-December 2008

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.

    2008-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment for all…

  16. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 18, Number 3. May-June 2005

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Walsh, Eileen, Ed.

    2005-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  17. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 16, Number 1. January-February 2002

    Science.gov (United States)

    Zamani, Rahman, Ed.; Guralnick, Eva, Ed.; Kunitz, Judith, Ed.

    2002-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  18. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 22, Number 1, January-February 2009

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.

    2009-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  19. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 22, Number 3, May-June 2009

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2009-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  20. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 18, Number 5. September-October 2005

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Walsh, Eileen, Ed.

    2005-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  1. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 20, Number 4. July-August 2007

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2007-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  2. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 20, Number 1. January-February 2007

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2007-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  3. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 21, Number 3, May-June 2008

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.

    2008-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of this newsletter are to promote and support a healthy and safe environment…

  4. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 17, Number 1. January-February 2004

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Lucich, Mardi, Ed.

    2004-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  5. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 22, Number 4, July-August 2009

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2009-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment for all…

  6. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 18, Number 4. July-August 2005

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Walsh, Eileen, Ed.

    2005-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  7. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 17, Number 4. July-August 2004

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Kunitz, Judith Ed.; Lucich, Mardi, Ed.; Walsh, Eileen, Ed.

    2004-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  8. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 20, Number 5, September-October 2007

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2007-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  9. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 21, Number 4, July-August 2008

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.

    2008-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  10. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 17, Number 2. March-April 2004

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Lucich, Mardi, Ed.

    2004-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  11. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 23, Number 3, May-June 2010

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2010-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of this newsletter are to promote and support a healthy and safe environment for all…

  12. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 17, Number 3. May-June 2004

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Kunitz, Judith, Ed.; Lucich, Mardi, Ed.

    2004-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  13. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 17, Number 6. November-December 2004

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Lucich, Mardi, Ed.; Walsh, Eileen, Ed.

    2004-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  14. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 20, Number 2, March-April 2007

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2007-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  15. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 23, Number 2, March-April 2010

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2010-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  16. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 16, Number 4. July-August 2003

    Science.gov (United States)

    Zamani, Rahman, Ed.; Guralnick, Eva, Ed.; Kunitz, Judith Ed.

    2003-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  17. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 19, Number 2, March-April 2006

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2006-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  18. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 19, Number 5, September-October 2006

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2006-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of this newsletter are to promote and support a healthy and safe environment…

  19. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 22, Number 2, March-April 2009

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2009-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment for all…

  20. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 16, Number 5. September-October 2003

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Jensen, Susan, Ed.; Lucich, Mardi, Ed.

    2003-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  1. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 18, Number 2. March-April 2005

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Walsh, Eileen, Ed.

    2005-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  2. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 22, Number 6, November-December 2009

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2009-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  3. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 22, Number 5, September-October 2009

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2009-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  4. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 18, Number 1. January-February 2005

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Guralnick, Eva, Ed.; Calder, Judy, Ed.; Walsh, Eileen, Ed.

    2005-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  5. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 18, Number 6. November-December 2005

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.

    2005-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  6. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 23, Number 4, July-August 2010

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Rose, Bobbie, Ed.; Calder, Judy, Ed.; Garakani, Tahereh, Ed.; Leonard, Victoria, Ed.

    2010-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  7. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 20, Number 6, November-December 2007

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2007-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of this newsletter are to promote and support a healthy and safe environment…

  8. Child Care Health Connections: A Health and Safety Newsletter for California Child Care Professionals. Volume 19, Number 3, May-June 2006

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.; Gendell, Mara, Ed.

    2006-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  9. Child Care Health Connections. A Health and Safety Newsletter for California Child Care Professionals. Volume 21, Number 2. March-April 2008

    Science.gov (United States)

    Zamani, A. Rahman, Ed.; Calder, Judy, Ed.; Rose, Bobbie, Ed.; Leonard, Victoria, Ed.

    2008-01-01

    "Child Care Health Connections" is a bimonthly newsletter published by the California Childcare Health Program (CCHP), a community-based program of the University of California, San Francisco School of Nursing, Department of Family Health Care Nursing. The goals of the newsletter are to promote and support a healthy and safe environment…

  10. Activation of phagocytic cells by Staphylococcus epidermidis biofilms: effects of extracellular matrix proteins and the bacterial stress protein GroEL on netosis and MRP-14 release.

    Science.gov (United States)

    Dapunt, Ulrike; Gaida, Matthias M; Meyle, Eva; Prior, Birgit; Hänsch, Gertrud M

    2016-07-01

    The recognition and phagocytosis of free-swimming (planktonic) bacteria by polymorphonuclear neutrophils have been investigated in depth. However, less is known about the neutrophil response towards bacterial biofilms. Our previous work demonstrated that neutrophils recognize activating entities within the extracellular polymeric substance (EPS) of biofilms (the bacterial heat shock protein GroEL) and that this process does not require opsonization. Aim of this study was to evaluate the release of DNA by neutrophils in response to biofilms, as well as the release of the inflammatory cytokine MRP-14. Neutrophils were stimulated with Staphylococcus epidermidis biofilms, planktonic bacteria, extracted EPS and GroEL. Release of DNA and of MRP-14 was evaluated. Furthermore, tissue samples from patients suffering from biofilm infections were collected and evaluated by histology. MRP-14 concentration in blood samples was measured. We were able to show that biofilms, the EPS and GroEL induce DNA release. MRP-14 was only released after stimulation with EPS, not GroEL. Histology of tissue samples revealed MRP-14 positive cells in association with neutrophil infiltration and MRP-14 concentration was elevated in blood samples of patients suffering from biofilm infections. Our data demonstrate that neutrophil-activating entities are present in the EPS and that GroEL induces DNA release by neutrophils.

  11. Simultaneous NuSTAR/Chandra Observations of The Bursting Pulsar GRO J1744-28 During Its Third Reactivation

    DEFF Research Database (Denmark)

    Younes, G.; Kouveliotou, C.; Grefenstette, B. W.;

    2015-01-01

    keV with an Eddington persistent flux level. Seven bursts, followed by dips, are seen with Chandra, three of which are also detected with NuSTAR. Timing analysis reveals a slight increase in the persistent emission pulsed fraction with energy (from 10% to 15%) up to 10 keV, above which it remains......We report on a 10 ks simultaneous Chandra/High Energy Transmission Grating (HETG)-Nuclear Spectroscopic Telescope Array (NuSTAR) observation of the Bursting Pulsar, GRO J1744-28, during its third detected outburst since discovery and after nearly 18 yr of quiescence. The source is detected up to 60...

  12. EMTC Newsletter

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner; Lerner, Adrienne; Suvini, Ferdinando

    2014-01-01

    The EMTC is a confederation of professional music therapy associations, working actively to promote the further development of professional practice in Europe, and to foster exchange and collaboration between member countries. The overall purpose of the EMTC is to nurture mutual respect, understa...

  13. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC

    Institute of Scientific and Technical Information of China (English)

    Fei Dong; Yi-Ru Du; Wenrui Xie; Judith A.Strong; Xi-Jing He; Jun-Ming Zhang

    2012-01-01

    Objective Inflammation at the level of the sensory dorsal root ganglia (DRGs) leads to robust mechanical pain behavior and the local inflammation has direct excitatory effects on sensory neurons including small,primarily nociceptive,neurons.These neurons express the transient receptor potential vanilloid-1 (TRPV 1) channel,which integrates multiple signals of pain and inflammation.The aim of this study was to characterize the regulation of the TRPV1 channel by local DRG inflammation and by growth-related oncogene (GRO/KC,systemic name:CXCL1),a cytokine known to be upregulated in inflamed DRGs.Methods Activation of the TRPV1 receptor with capsaicin was studied with patch clamp methods in acutely isolated small-diameter rat sensory neurons in primary culture.In vivo,behavioral effects of TRPV1 and GRO/KC were examined by paw injections.Results Neurons isolated from lumbar DRGs 3 days after local inflammation showed enhanced TRPV1 function:tachyphylaxis (the decline in response to repeated applications of capsaicin) was significantly reduced.A similar effect on tachyphylaxis was observed in neurons pre-treated for 4 h in vitro with GRO/KC.This effect was blocked by H-89,a protein kinase A inhibitor.Consistent with the in vitro results,in vivo behavioral responses to paw injection of capsaicin were enhanced and prolonged by pre-injecting the paw with GRO/KC 4 h before the capsaicin injection.GRO/KC paw injections alone did not elicit pain behaviors.Conclusion Function of the TRPV 1 channel is enhanced by DRG inflammation and these effects are preserved in vitro during short-term culture.The effects (decreased tachyphylaxis) are mimicked by incubation with GRO/KC,which has previously been found to be strongly upregulated in this and other pain models.

  14. INTEGRAL detection of the multi-peaked emission from the Be/X-ray binary pulsar GRO J1008-57

    DEFF Research Database (Denmark)

    Fiocchi, M.; Sguera, A.; Chenevez, Jérôme

    2014-01-01

    Recent observations from the on-going INTEGRAL Galactic Plane Scanning programme (PI: A. Bazzano) have detected increasing X-ray flux from the Be/X-ray binary pulsar GRO J1008-57, confirming the re-brightening detected by MAXI/GSC (ATel #6819). The source was in the field of view of the IBIS...

  15. Electron microscopy and image analysis of the GroEL-like protein and its complexes with glutamine synthetase from pea leaves

    NARCIS (Netherlands)

    Tsuprun, Vladimir L.; Boekema, Egbert J.; Pushkin, Alexander V.; Tagunova, Irina V.

    1992-01-01

    The molecular structure of groEL-like protein from pea leaves has been studied by electron microscopy and image analysis of negatively stained particles. Over 1500 molecular projections were selected and classified by multivariate statistical analysis. It was shown that the molecule consists of 14 s

  16. Growth performance and resistance to Streptococcus iniae of juvenile Nile tilapia (Oreochromis niloticus) fed diets supplemented with GroBiotic - A and Brewtech Dried Brewers Yeast

    Science.gov (United States)

    This study was conducted to evaluate the effect of dietary levels of Brewtech® dried brewers yeast (BY) and GroBiotic®-A (GB) on growth performance, proximate body composition, immune response and resistance of juvenile Nile tilapia to Streptococcus iniae challenge. A practical basal (control) diet ...

  17. Detection of the Host Immune Response to Burkholderia mallei Heat-Shock Proteins GroEL and DnaK in a Glanders Patient and Infected Mice

    Science.gov (United States)

    2007-01-01

    infected animal are the most common methods of acquiring glanders because the organism can be trans- mitted through droplets or saliva . In horses...host cell. A GroEL-like protein in Actinobacillus actinomycetemcomitans, a patho- gen associated with periodontal disease, was found in extracellular

  18. Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice.

    Science.gov (United States)

    Amemiya, Kei; Meyers, Jennifer L; Deshazer, David; Riggins, Renaldo N; Halasohoris, Stephanie; England, Marilyn; Ribot, Wilson; Norris, Sarah L; Waag, David M

    2007-10-01

    We examined, by enzyme-linked immunosorbent assay and Western blot analysis, the host immune response to 2 heat-shock proteins (hsps) in a patient and mice previously infected with Burkholderia mallei. The patient was the first reported human glanders case in 50 years in the United States. The expression of the groEL and dnaK operons appeared to be dependent upon a sigma(32) RNA polymerase as suggested by conserved heat-shock promoter sequences, and the groESL operon may be negatively regulated by a controlling invert repeat of chaperone expression (CIRCE) site. In the antisera, the GroEL protein was found to be more immunoreactive than the DnaK protein in both a human patient and mice previously infected with B. mallei. Examination of the supernatant of a growing culture of B. mallei showed that more GroEL protein than DnaK protein was released from the cell. This may occur similarly within an infected host causing an elevated host immune response to the B. mallei hsps.

  19. Nucleolin inhibitor GroA triggers reduction in epidermal growth factor receptor activation: Pharmacological implication for glial scarring after spinal cord injury.

    Science.gov (United States)

    Goldshmit, Yona; Schokoroy Trangle, Sari; Afergan, Fabian; Iram, Tal; Pinkas-Kramarski, Ronit

    2016-09-01

    Glial scarring, formed by reactive astrocytes, is one of the major impediments for regeneration after spinal cord injury (SCI). Reactive astrocytes become hypertrophic, proliferate and secrete chondroitin sulphate proteoglycans into the extracellular matrix (ECM). Many studies have demonstrated that epidermal growth factor receptors (EGFR) can mediate astrocyte reactivity after neurotrauma. Previously we showed that there is crosstalk between nucleolin and EGFR that leads to increased EGFR activation followed by increased cell proliferation. Treatment with the nucleolin inhibitor GroA (AS1411) prevented these effects in vitro and in vivo. In this study, we hypothesized that similar interactions may mediate astrogliosis after SCI. Our results demonstrate that nucleolin and EGFR interaction may play a pivotal role in mediating astrocyte proliferation and reactivity after SCI. Moreover, we demonstrate that treatment with GroA reduces EGFR activation, astrocyte proliferation and chondroitin sulphate proteoglycans secretion, therefore promoting axonal regeneration and sprouting into the lesion site. Our results identify, for the first time, a role for the interaction between nucleolin and EGFR in astrocytes after SCI, indicating that nucleolin inhibitor GroA may be used as a novel treatment after neurotrauma. A major barrier for axonal regeneration after spinal cord injury is glial scar created by reactive and proliferating astrocytes. EGFR mediate astrocyte reactivity. We showed that inhibition of nucleolin by GroA, reduces EGFR activation, which results in attenuation of astrocyte reactivity and proliferation in vivo and in vitro. EGFR, epidermal growth factor receptor.

  20. Bone marrow mast cell density correlates with serum levels of VEGF and CXC chemokines ENA-78 and GRO-α in multiple myeloma.

    Science.gov (United States)

    Pappa, C A; Tsirakis, G; Devetzoglou, M; Zafeiri, M; Vyzoukaki, R; Androvitsanea, A; Xekalou, A; Sfiridaki, K; Alexandrakis, M G

    2014-06-01

    Angiogenesis is a crucial process in growth and progression of multiple myeloma (MM). Mast cells (MCs) play an important role in MM angiogenesis. Various angiogenic mediators secreted by MCs regulate endothelial cell proliferation and function. Among them, ELR(+) CXC chemokines, such as growth-related oncogen-alpha (GRO-α) and epithelial neutrophil activating protein-78 (ENA-78), have been described as potential mediators in regulation of angiogenesis. The purpose of the study was to quantify MCs in bone marrow (BM) biopsies of MM patients, expressed as MC density (MCD), and correlate it with serum concentrations of vascular endothelial factor (VEGF), GRO-α, ENA-78. Fifty-four newly diagnosed MM patients and 22 healthy controls were studied. Tryptase was used for the immunohistochemical stain of MCs. VEGF, GRO-α, and ENA-78 were measured in sera by ELISA. MCD and serum levels of GRO-α, ENA-78, and VEGF were significantly higher in MM patients compared to controls (pENA-78. These findings support that MCs participate in the pathophysiology of MM and is implicated in the angiogenic process and disease progression.

  1. The htpAB operon of Legionella pneumophila cannot be deleted in the presence of the groE chaperonin operon of Escherichia coli.

    Science.gov (United States)

    Nasrallah, Gheyath K; Gagnon, Elizabeth; Orton, Dennis J; Garduño, Rafael A

    2011-11-01

    HtpB, the chaperonin of the intracellular bacterial pathogen Legionella pneumophila , displays several virulence-related functions in vitro. To confirm HtpB's role in vivo, host infections with an htpB deletion mutant would be required. However, we previously reported that the htpAB operon (encoding co-chaperonin and chaperonin) is essential. We attempted here to delete htpAB in a L. pneumophila strain carrying the groE operon (encoding the Escherichia coli co-chaperonin and chaperonin). The groE operon was inserted into the chromosome of L. pneumophila Lp02, and then allelic replacement of htpAB with a gentamicin resistance cassette was attempted. Although numerous potential postallelic replacement transformants showed a correct selection phenotype, we still detected htpAB by PCR and full-size HtpB by immunoblot. Southern blot and PCR analysis indicated that the gentamicin resistance cassette had apparently integrated in a duplicated htpAB region. However, we showed by Southern blot that strain Lp02, and the Lp02 derivative carrying the groE operon, have only one copy of htpAB. These results confirmed that the htpAB operon cannot be deleted, not even in the presence of the groE operon, and suggested that attempts to delete htpAB under strong phenotypic selection result in aberrant genetic recombinations that could involve duplication of the htpAB locus.

  2. Von Nobel bis Viagra: Die Geschichte eines kleinen Moleküls mit großer Wirkung: Stickstoffmonoxyd (NO

    Directory of Open Access Journals (Sweden)

    Philipp T

    2010-01-01

    Full Text Available Es wird kurzgefasst die Geschichte des Nitroglyzerins und von Alfred Nobel dargestellt. Nitroglyzerin war als explosiver Bestandteil von Dynamit der gewaltigste Sprengstoff seiner Zeit und wurde von Alfred Nobel weiterentwickelt und kommerzialisiert, der später den Nobelpreis stiftete. Gleichermaßen ist Nitroglyzerin in öliger Dispersion und in geringsten Mengen seit 100 Jahren als „Koronardilatator“ eingeführt und weiterhin nahezu unersetzlich. Der Mechanismus, mit dem Nitroglyzerin Gefäße erweitert, wurde erst vor 25 Jahren von Furchgott, Ignarro und Murad vollständig aufgeklärt, indem sie die große Bedeutung des Endothels und des gefäßerweiternden Stickstoffmonoxyds beschrieben. Die 3 Forscher erhielten 1998 den Nobelpreis für Medizin zu gleichen Teilen "für die Entdeckung des NOs als Signalmolekül für das kardiovaskuläre System".

  3. Chaperonin GroEL a Brucella immunodominant antigen identified using Nanobody and MALDI-TOF-MS technologies.

    Science.gov (United States)

    Abbady, A Q; Al-Daoude, A; Al-Mariri, A; Zarkawi, M; Muyldermans, S

    2012-05-15

    The deployment of today's antibodies that are able to distinguish Brucella from the closely similar pathogens, such as Yersinia, is still considered a great challenge since both pathogens share identical LPS (lipopolysaccharide) O-ring epitopes. In addition, because of the great impact of Brucella on health and economy in many countries including Syria, much effort is going to the development of next generation vaccines, mainly on the identification of new immunogenic proteins of this pathogen. In this context, Brucella-specific nanobodies (Nbs), camel genetic engineered heavy-chain antibody fragments, could be of great value. Previously, a large Nb library was constructed from a camel immunized with heat-killed Brucella. Phage display panning of this 'immune' library with Brucella total lysate resulted in a remarkable fast enrichment for a Nb referred to as NbBruc02. In the present work, we investigated the main characteristics of this Nb that can efficiently distinguish under well-defined conditions the Brucella from other bacteria including Yersinia. NbBruc02 showed a strong and specific interaction with its antigen within the crude lysate as tested by a surface plasmon resonance (SPR) biosensor and it was also able to pull down its cognate antigen from such lysate by immuno-capturing. Using matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), NbBruc02 specific antigen was identified as chaperonin GroEL, also known as heat shock protein of 60 kDa (HSP-60), which represents a Brucella immunodominant antigen responsible of maintaining proteins folding during stress conditions. Interestingly, the antigen recognition by NbBruc02 was found to be affected by the state of GroEL folding. Thus, the Nb technology applied in the field of infectious diseases, e.g. brucellosis, yields two outcomes: (1) it generates specific binders that can be used for diagnosis, and perhaps treatment, and (2) it identifies the immunogenic candidate

  4. Enhanced translocation and growth of Rhodococcus erythropolis PR4 in the alkane phase of aqueous-alkane two phase cultures were mediated by GroEL2 overexpression.

    Science.gov (United States)

    Takihara, Hayato; Ogihara, Jun; Yoshida, Takao; Okuda, Shujiro; Nakajima, Mutsuyasu; Iwabuchi, Noriyuki; Sunairi, Michio

    2014-01-01

    We previously reported that R. erythropolis PR4 translocated from the aqueous to the alkane phase, and then grew in two phase cultures to which long-chain alkanes had been added. This was considered to be beneficial for bioremediation. In the present study, we investigated the proteins involved in the translocation of R. erythropolis PR4. The results of our proteogenomic analysis suggested that GroEL2 was upregulated more in cells that translocated inside of the pristane (C19) phase than in those located at the aqueous-alkane interface attached to the n-dodecane (C12) surface. PR4 (pK4-EL2-1) and PR4 (pK4-ΔEL2-1) strains were constructed to confirm the effects of the upregulation of GroEL2 in translocated cells. The expression of GroEL2 in PR4 (pK4-EL2-1) was 15.5-fold higher than that in PR4 (pK4-ΔEL2-1) in two phase cultures containing C12. The growth and cell surface lipophilicity of PR4 were enhanced by the introduction of pK4-EL2-1. These results suggested that the plasmid overexpression of groEL2 in PR4 (pK4-EL2-1) led to changes in cell localization, enhanced growth, and increased cell surface lipophilicity. Thus, we concluded that the overexpression of GroEL2 may play an important role in increasing the organic solvent tolerance of R. erythropolis PR4 in aqueous-alkane two phase cultures.

  5. Authormagic: Ein Konzept zur Autorenidentifikation in Großen Digitalen Bibliotheken

    CERN Document Server

    Weiler, Henning

    2012-01-01

    Author name ambiguities distort the quality of information discovery in digital libraries. These ambiguities also contribute to the inaccurate attribution of authorship to individual researchers. The latter is especially delicate in research evaluation. To solve this issue, many algorithmic bulk disambiguation approaches have been proposed in the literature. However, no algorithmic approach can solve author ambiguities with an accuracy of 100%. Some online projects allow users to manually create publication lists, which are then regarded as profiles of the researchers. The tedious work to manually assemble such publication lists and the unavailability of scientific material in these projects limit the success of these projects. The “Authormagic” concept is developed in this thesis to address the author ambiguity issue with a hybrid approach of combining algorithmic and human intelligence. A customized agglomerative clustering approach first determines publication clusters by comparing available metadata. ...

  6. New England Wind Forum, Volume 1, Issue 1 -- January 2006

    Energy Technology Data Exchange (ETDEWEB)

    2006-01-01

    The New England Wind Forum electronic newsletter summarizes the latest news in wind energy development activity, markets, education and policy in the New England region. It also features an interview with a key figure influencing New England's wind energy development. Volume 1, Issue 1 features an interview with Brother Joseph of Portsmouth Abbey. A commercial-scale Vestas V47 wind turbine will soon be installed on the grounds of the Benedictine monastery and prep school in Rhode Island, with the assistance of a grant from the Rhode Island Renewable Energy Fund. This will be the first large-scale turbine located behind the customer meter in the region.

  7. Binding of Haemophilus ducreyi to carbohydrate receptors is mediated by the 58.5-kDa GroEL heat shock protein.

    Science.gov (United States)

    Pantzar, Martina; Teneberg, Susann; Lagergård, Teresa

    2006-08-01

    The bacterium Haemophilus ducreyi causes the sexually transmitted disease chancroid, which is characterized by the appearance of mucocutaneous, persistent ulcers on the external genitals. To identify carbohydrate receptors that mediate the attachment of this pathogen to host cells, we investigated the binding of 35S-methionine-labeled H. ducreyi strains to a panel of defined glycosphingolipids that were separated on thin layer chromatography plates. H. ducreyi bound to lactosylceramide, gangliotriaosylceramide, gangliotetraosylceramide, neolactotetraosylceramide, the GM3 ganglioside, and sulfatide. To elucidate the role of the surface-located 58.5-kDa GroEL heat shock protein (HSP) of H. ducreyi in attachment, we investigated the binding of purified HSP to the same panel of glycosphingolipids. Our results suggest that the 58.5-kDa GroEL HSP of H. ducreyi is responsible for the attachment of this bacterium to the majority of the tested glycosphingolipids, and thus represents a potential bacterial adhesin.

  8. Arsenophonus GroEL interacts with CLCuV and is localized in midgut and salivary gland of whitefly B. tabaci.

    Directory of Open Access Journals (Sweden)

    Vipin Singh Rana

    Full Text Available Cotton leaf curl virus (CLCuV (Gemininiviridae: Begomovirus is the causative agent of leaf curl disease in cotton plants (Gossypium hirsutum. CLCuV is exclusively transmitted by the whitefly species B. tabaci (Gennadius (Hemiptera: Alerodidae. B. tabaci contains several biotypes which harbor dissimilar bacterial endo-symbiotic community. It is reported that these bacterial endosymbionts produce a 63 kDa chaperon GroEL protein which binds to geminivirus particles and protects them from rapid degradation in gut and haemolymph. In biotype B, GroEL protein of Hamiltonella has been shown to interact with Tomato yellow leaf curl virus (TYLCV. The present study was initiated to find out whether endosymbionts of B. tabaci are similarly involved in CLCuV transmission in Sriganganagar (Rajasthan, an area endemic with cotton leaf curl disease. Biotype and endosymbiont diversity of B. tabaci were identified using MtCO1 and 16S rDNA genes respectively. Analysis of our results indicated that the collected B. tabaci population belong to AsiaII genetic group and harbor the primary endosymbiont Portiera and the secondary endosymbiont Arsenophonus. The GroEL proteins of Portiera and Arsenophonus were purified and in-vitro interaction studies were carried out using pull down and co-immunoprecipitation assays. In-vivo interaction was confirmed using yeast two hybrid system. In both in-vitro and in-vivo studies, the GroEL protein of Arsenophonus was found to be interacting with the CLCuV coat protein. Further, we also localized the presence of Arsenophonus in the salivary glands and the midgut of B. tabaci besides the already reported bacteriocytes. These results suggest the involvement of Arsenophonus in the transmission of CLCuV in AsiaII genetic group of B. tabaci.

  9. Arsenophonus GroEL interacts with CLCuV and is localized in midgut and salivary gland of whitefly B. tabaci.

    Science.gov (United States)

    Rana, Vipin Singh; Singh, Shalini Thakur; Priya, Natarajan Gayatri; Kumar, Jitendra; Rajagopal, Raman

    2012-01-01

    Cotton leaf curl virus (CLCuV) (Gemininiviridae: Begomovirus) is the causative agent of leaf curl disease in cotton plants (Gossypium hirsutum). CLCuV is exclusively transmitted by the whitefly species B. tabaci (Gennadius) (Hemiptera: Alerodidae). B. tabaci contains several biotypes which harbor dissimilar bacterial endo-symbiotic community. It is reported that these bacterial endosymbionts produce a 63 kDa chaperon GroEL protein which binds to geminivirus particles and protects them from rapid degradation in gut and haemolymph. In biotype B, GroEL protein of Hamiltonella has been shown to interact with Tomato yellow leaf curl virus (TYLCV). The present study was initiated to find out whether endosymbionts of B. tabaci are similarly involved in CLCuV transmission in Sriganganagar (Rajasthan), an area endemic with cotton leaf curl disease. Biotype and endosymbiont diversity of B. tabaci were identified using MtCO1 and 16S rDNA genes respectively. Analysis of our results indicated that the collected B. tabaci population belong to AsiaII genetic group and harbor the primary endosymbiont Portiera and the secondary endosymbiont Arsenophonus. The GroEL proteins of Portiera and Arsenophonus were purified and in-vitro interaction studies were carried out using pull down and co-immunoprecipitation assays. In-vivo interaction was confirmed using yeast two hybrid system. In both in-vitro and in-vivo studies, the GroEL protein of Arsenophonus was found to be interacting with the CLCuV coat protein. Further, we also localized the presence of Arsenophonus in the salivary glands and the midgut of B. tabaci besides the already reported bacteriocytes. These results suggest the involvement of Arsenophonus in the transmission of CLCuV in AsiaII genetic group of B. tabaci.

  10. "Kein Zeugnis abzulegen, wäre Verrat": Holocaustausstellungen an Stätten des Gedenkens im internationalen Vergleich – Deutschland, Frankreich, Großbritannien und Israel

    OpenAIRE

    Hofer-Englmaier, Iris Pamela Anna

    2015-01-01

    Die Studie zielt auf eine vergleichende Analyse der ausstellerischen Diskurse von Stätten des Gedenkens an den Holocaust in den Ländern Großbritannien, Frankreich, Israel und Deutschland. Hierbei wird der Begriff des Holocaust so weit gefasst, wie es im englischsprachigen Diskurs üblich ist. Er beinhaltet neben den Juden auch andere Bevölkerungsgruppen, die von den Nationalsozialisten verfolgt wurden. Untersucht werden konkret das Imperial War Museum, London's Museum of Jewish Life und d...

  11. Controversy of the GRO J1655-40 black hole mass and spin estimates and its possible solutions

    CERN Document Server

    Stuchlík, Zdeněk

    2016-01-01

    Estimates of the black hole mass $M$ and dimensionless spin $a$ in the microquasar GRO J1655-40 implied by strong gravity effects related to the timing and spectral measurements are controversial, if the mass restriction determined by the dynamics related to independent optical measurements, $M_{\\rm opt}=(5.4\\pm0.3) M_{\\odot}$, are applied. The timing measurements of twin high-frequency (HF) quasiperiodic oscillations (QPOs) with frequency ratio $3:2$ and the simultaneously observed low-frequency (LF) QPO imply the spin in the range $a\\in(0.27-0.29)$ if models based on the frequencies of the geodesic epicyclic motion are used to fit the timing measurements, and correlated creation of the twin HF QPOs and the LF QPO at a common radius is assumed. On the other hand, the spectral continuum method implies $a\\in(0.65-0.75)$, and the Fe-line-profile method implies $a\\in(0.94-0.98)$. This controversy can be cured, if we abandon the assumption of the occurrence of the twin HF QPOs and the simultaneously observed LF Q...

  12. Simultaneous NuSTAR/Chandra observations of the Bursting Pulsar GRO J1744-28 during its third reactivation

    CERN Document Server

    Younes, G; Grefenstette, B W; Tomsick, J A; Tennant, A; Finger, M H; Furst, F; Pottschmidt, K; Bhalerao, V; Boggs, S E; Boirin, L; Chakrabarty, D; Christensen, F E; Craig, W W; Degenaar, N; Fabian, A C; Gandhi, P; Gogus, E; Hailey, C J; Harrison, F A; Kennea, J A; Miller, J M; Stern, D; Zhang, W W

    2015-01-01

    We report on a 10 ks simultaneous Chandra/HETG-NuSTAR observation of the Bursting Pulsar, GRO J1744-28, during its third detected outburst since discovery and after nearly 18 years of quiescence. The source is detected up to 60 keV with an Eddington persistent flux level. Seven bursts, followed by dips, are seen with Chandra, three of which are also detected with NuSTAR. Timing analysis reveals a slight increase in the persistent emission pulsed fraction with energy (from 10% to 15%) up to 10 keV, above which it remains constant. The 0.5-70 keV spectra of the persistent and dip emission are the same within errors, and well described by a blackbody (BB), a power-law with an exponential rolloff, a 10 keV feature, and a 6.7 keV emission feature, all modified by neutral absorption. Assuming that the BB emission originates in an accretion disc, we estimate its inner (magnetospheric) radius to be about 4x10^7 cm, which translates to a surface dipole field B~9x10^10 G. The Chandra/HETG spectrum resolves the 6.7 keV ...

  13. Primjena nove tehnike prosušivanja bobica grožđa za proizvodnju prošeka

    OpenAIRE

    Sito, Stjepan; Peršurić Bernobić, Katarina; Bilandžija, Nikolina; Kraljević, Ante; Sinković, Ana; Sinković, Petra

    2013-01-01

    U radu su prikazani rezultati pokusnog prosušivanja grožđa sorti Muškat žuti i Muškat ruža crni dopremljenih iz vinograda blizu Poreča s OPG-a Peršurić Đordano. Uzorci prije sušenja sorte Muškat žuti imali su sadržaj šećera 87ºOe (186 g/L), a Muškat ruža crni 91ºOe (200 g/L). Nakon sušenja sadržaj šećera u soku bobica bio je oko 173ºOe (378 g/L). Proces prosušivanja uzoraka sorte Muškat žuti trajao je 120 sati, a kod sorte Muškat ruža crni 108 sati pri temperaturi zraka za sušenje od 35-38°C ...

  14. Die Facharztweiterbildung in Großbritannien oder die "Modernisierung der ärztlichen Karrieren" [Modernising Medical Careers

    Directory of Open Access Journals (Sweden)

    du Moulin, Marcel

    2007-05-01

    Full Text Available [english] This paper analyses the reform of postgraduate medical education introduced in the United Kingdom in 2003 under the heading "Modernising Medical Careers“. This nationally standardised and structured postgraduate medical training was started in 2005. The analysis includes the transition from undergraduate to postgraduate education, the new responsibilities in postgraduate education, the application process and the mode of distribution of the positions and the relationship of posts with and without postgraduate training opportunities. Possible consequences for postgraduate training and for the trainees are discussed. [german] Die Arbeit beschreibt und analysiert die Reform der Facharztweiterbildung in Großbritannien, die 2003 unter dem Titel "Modernising Medical Careers“ eingeführt wurde und seit 2005 umgesetzt wird. Vorgestellt werden der Übergang von der Ausbildung zur Weiterbildung, die neuen Zuständigkeiten für die Weiterbildung, das Auswahlverfahren und der Verteilungsmodus der Weiterbildungsstellen sowie das Verhältnis von Stellen mit und ohne Facharztperspektive. Die potenziellen Folgen für die Facharztweiterbildung und für die Weitergebildeten werden diskutiert.

  15. A preliminary in vitro assessment of GroBiotic-A, brewer's yeast and fructooligosaccharide as prebiotics for the red drum Sciaenops ocellatus.

    Science.gov (United States)

    Burr, Gary; Hume, Michael; Ricke, Steven; Nisbet, David; Gatlin, Delbert

    2008-01-01

    This study examined the effects of brewers yeast, fructooligosaccharide (FOS), and GroBiotic-A, a mixture of partially autolyzed brewers yeast, dairy components and dried fermentation products, on the intestinal microbial community of red drum, Sciaenops ocellatus. Gastrointestinal (GI) tracts were aseptically removed from three sub-adult red drum previously maintained on a commercial diet and placed in an anaerobic chamber. Intestinal contents were removed, diluted and incubated in vitro in one of four liquid media: normal diet alone, diet + 2% (w/w) GroBiotic-A, diet + 2% brewers yeast, and diet + 2% FOS. After 24 and 48 h of incubation at 25 degrees C, supernatants were removed for volatile fatty acid (VFA) analysis and DNA was extracted for denaturing gradient gel electrophoresis (DGGE) analysis. Polymerase chain reaction (PCR) was performed on a highly conserved region of M 16S rDNA and the amplicons were subjected to DGGE. The microbial community (MC) fingerprint was used to distinguish microbial populations. The intestinal contents incubated with GroBiotic-A had significantly (Pyeast.

  16. The Effects of Heterologous Expression of groEL from Arthrobacter simplex on the Resistance Performance of Escherichia coli%简单节杆菌groEL基因表达对大肠杆菌抗逆性能的影响

    Institute of Scientific and Technical Information of China (English)

    王艳霞; 王红玲; 王敏; 骆健美

    2016-01-01

    Arthrobacter simplex,a strain with steroid C1,2 dehydrogenation ability,has been widely used in the steroid industry, usually adding ethanol in the transforming system may catalyze the dissolution of hydrophobic substrates. Our prior work by LC-MS/MS and bioinformatics analysis found that heat shock protein(HSP)GroEL was closely correlated to the cell adaptive behavior under ethanol stress condition. Based on this concept,groEL gene was cloned by PCR while usingA. simplexTCCC 11037 genome as a template. The results showed that the homologies of nucleotide and amino acid sequence of GroEL in the strain were the highest with that fromNocardioides sp. JS614 by the ratio of 89% and 95%,respectively. Then its heterologous expression was conducted in Escherichia coli BL21(DE3)with the vector pET-22b (+),and the results showed that the recombinant strain presented the significant increase on the survival performance under the shock condition with high-concentration of methanol,hypertonicity and superacid,as well as the growth performance under the proper stresses of them. The study was the first report on the cloning and expression of genegroEL fromA. simplex,and also provided fundamental data for exploring the biological function of HSP protein GroEL from A. simplex.%以简单节杆菌(Arthrobacter simplex)TCCC 11037基因组为模板,通过PCR方法进行groEL基因克隆,结果表明,该菌株中GroEL的核苷酸和氨基酸序列与Nocardioidessp. JS614来源的GroEL同源性最高,分别为89%和95%。通过pET-22b(+)将其在大肠杆菌BL21(DE3)中进行异源表达,结果表明,重组菌株在甲醇、高渗和强酸这3种压力高浓度冲击条件下的存活能力和适当压力条件下的生长性能均明显提高。

  17. Delirium: Issues for Older Adults

    Science.gov (United States)

    ... our e-newsletter! Aging & Health A to Z Delirium Unique to Older Adults This section provides information ... of life. Overview of this section: Differences between Delirium and Dementia Other Neurologic Disorders Some Important Causes ...

  18. ThegroE operon ofStreptococcus mutans with its expression and regulation%变异链球菌groE操纵子及其表达与调控

    Institute of Scientific and Technical Information of China (English)

    王一舟; 张雅琪; 牛雪微; 张志民

    2016-01-01

    变异链球菌耐受口腔内多种环境的变化,主要依赖于多种热休克蛋白基因的表达。其中,groE操纵子表达的GroES-GroEL蛋白可辅助新合成的以及变性的蛋白质折叠、组装、转运和降解,从而影响细胞的代谢。变异链球菌groE操纵子位于1 834 692~1 832 649位点,包括σA型启动子、分子伴侣表达反向重复序列(CIRCE)、groES和groEL及终止子,在进化上高度保守,其表达受热、酸、乙醇和过氧化氢等多种应激环境的诱导,受CtsR和HrcA蛋白的双重负性调节。groE操纵子的调控有HrcA-CIRCE系统负调控假说和CtsR的负调控两种方式,但其具体调控机制尚未在变异链球菌中得到充分证实。从分子水平上研究变异链球菌groE操纵子的结构和调控机制,有助于进一步阐明细胞的生理过程,为了解细胞在应激和病变状态下的分子调节机制打下基础。%Streptococcus mutans(S.mutans), as one of the primary cariogenic bacteria, can respond to several environmental stresses. This ability mainly depends on the translation and expression of variety of heat shock protein genes. groE operon, one of the best-studied heat shock genes, affects the metabolism of cells by translating the heat shock proteins, groES-groEL, which can mediate the folding, assembly, transport, and degradation of new or misfolding proteins. The groE operon locates in 1 834 692-1 832 649 sites, including a σA promoter, inverted repeat sequence(CIRCE), groES, groEL and a terminator. It is highly conserved, and can be induced to express by stress environment including heat, acid, ethanol and hydrogen peroxide. Both HrcA-CIRCE system and CtsR play a negative regulation role, without a clear mechanism. Studies, about the structure and regulation mechanism of S.mutans groE operon in a molecular level, help to further clarify the physiological process of cells, and lay the foundation for understanding the molecular

  19. Identification of gain- and loss-framed cancer screening messages that appeared in municipal newsletters in Japan.

    Science.gov (United States)

    Okuhara, Tsuyoshi; Ishikawa, Hirono; Okada, Hiroko; Kiuchi, Takahiro

    2014-12-11

    Research suggests that cancer screening messages are more persuasive when framed in terms of the costs of not obtaining screening (i.e., loss-framed) than when framed in terms of the benefits of obtaining screening (i.e., gain-framed). However, to what extent these findings have been integrated into public health practice is unknown. To analyze message framing of cancer screening information, the present study examined message framing of cancer screening announcement articles that appeared in municipal newsletters published from 23 wards in central Tokyo, Japan. Two independent raters coded the articles. Gain- and loss-framed sentences in each article were identified, and based on what the sentences conveyed, articles were classified into gain-framed, loss-framed, mixed-framed, and non-framed. Inter-rater reliability was acceptable (intraclass correlation coefficient = 0.88). Of the 129 articles evaluated, the total number of gain-framed sentences was 87, while that of loss-framed sentences was six. The total number of gain-framed articles was 32 (24.8%) while that of loss-framed articles was zero (0%). Five (3.9%) articles were mixed-framed. Ninety-two (71.3%) articles were non-framed. Cancer screening announcement articles of municipal newsletters were mostly non-framed or gain-framed in 23 Tokyo wards in Japan. The absence of loss-framed articles and only a small number of loss-framed messages indicate a missed opportunity to persuade readers to obtain cancer screenings. Loss-framed messages and articles need to be increased to enhance the persuasiveness of cancer screening information in municipal newsletters.

  20. FEMP Focus: 2011 Volume 20 Issue 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-04-05

    Department of Energy (DOE); Federal Energy Management Program; FEMP Focus Newsletter; December 2010; Alternative Financing, Guidance Documents, Recovery Act Technical Assistance, Training, Energy Awareness

  1. Controversy of the GRO J1655-40 Black Hole Mass and Spin Estimates and Its Possible Solutions

    Science.gov (United States)

    Stuchlík, Z.; Kološ, M.

    2016-07-01

    Estimates of the black hole mass M and the dimensionless spin a in the microquasar GRO J1655-40 implied by strong gravity effects related to the timing and spectral measurements are controversial, if the mass restriction determined by the dynamics related to independent optical measurements, M opt = (5.4 ± 0.3) M ⊙, is applied. The timing measurements of twin high-frequency (HF) quasiperiodic oscillations (QPOs) with the frequency ratio 3:2 and the simultaneously observed low-frequency (LF) QPO imply spin in the range a\\in (0.27{--}0.29) if models based on the frequencies of geodesic epicyclic motion are used to fit the timing measurements, and the correlated creation of the twin HF QPOs and the LF QPO at a common radius is assumed. On the other hand, the spectral continuum method implies a\\in (0.65{--}0.75), and the Fe-line-profile method implies a\\in (0.94{--}0.98). This controversy can be cured if we abandon the assumption of the occurrence of the twin HF QPOs and the simultaneously observed LF QPO at a common radius. We demonstrate that the epicyclic resonance model of the twin HF QPOs is able to predict the spin in agreement with the Fe-profile method, but no model based on the geodesic epicyclic frequencies can be in agreement with the spectral continuum method. We also show that the non-geodesic string loop oscillation model of twin HF QPOs predicts spin a > 0.3 under the optical measurement limit on the black hole mass, which is in agreement with both the spectral continuum and Fe-profile methods.

  2. Simultaneous NuSTAR/Chandra Observations of the Bursting Pulsar GRO J1744-28 during Its Third Reactivation

    Science.gov (United States)

    Younes, G.; Kouveliotou, C.; Grefenstette, B. W.; Tomsick, J. A.; Tennant, A.; Finger, M. H.; Fürst, F.; Pottschmidt, K.; Bhalerao, V.; Boggs, S. E.; Boirin, L.; Chakrabarty, D.; Christensen, F. E.; Craig, W. W.; Degenaar, N.; Fabian, A. C.; Gandhi, P.; Göğüş, E.; Hailey, C. J.; Harrison, F. A.; Kennea, J. A.; Miller, J. M.; Stern, D.; Zhang, W. W.

    2015-05-01

    We report on a 10 ks simultaneous Chandra/High Energy Transmission Grating (HETG)-Nuclear Spectroscopic Telescope Array (NuSTAR) observation of the Bursting Pulsar, GRO J1744-28, during its third detected outburst since discovery and after nearly 18 yr of quiescence. The source is detected up to 60 keV with an Eddington persistent flux level. Seven bursts, followed by dips, are seen with Chandra, three of which are also detected with NuSTAR. Timing analysis reveals a slight increase in the persistent emission pulsed fraction with energy (from 10% to 15%) up to 10 keV, above which it remains constant. The 0.5-70 keV spectra of the persistent and dip emission are the same within errors and well described by a blackbody (BB), a power-law (PL) with an exponential rolloff, a 10 keV feature, and a 6.7 keV emission feature, all modified by neutral absorption. Assuming that the BB emission originates in an accretion disk, we estimate its inner (magnetospheric) radius to be about 4 × 107 cm, which translates to a surface dipole field B ≈ 9 × 1010 G. The Chandra/HETG spectrum resolves the 6.7 keV feature into (quasi-)neutral and highly ionized Fe xxv and Fe xxvi emission lines. XSTAR modeling shows these lines to also emanate from a truncated accretion disk. The burst spectra, with a peak flux more than an order of magnitude higher than Eddington, are well fit with a PL with an exponential rolloff and a 10 keV feature, with similar fit values compared to the persistent and dip spectra. The burst spectra lack a thermal component and any Fe features. Anisotropic (beamed) burst emission would explain both the lack of the BB and any Fe components.

  3. SIMULTANEOUS NuSTAR/CHANDRA OBSERVATIONS OF THE BURSTING PULSAR GRO J1744-28 DURING ITS THIRD REACTIVATION

    Energy Technology Data Exchange (ETDEWEB)

    Younes, G.; Finger, M. H. [Universities Space Research Association, 6767 Old Madison Pike, Suite 450, Huntsville, AL 35806 (United States); Kouveliotou, C.; Tennant, A. [Astrophysics Office, ZP 12, NASA-Marshall Space Flight Center, Huntsville, AL 35812 (United States); Grefenstette, B. W.; Fürst, F. [Cahill Center for Astrophysics, 1216 East California Boulevard, California Institute of Technology, Pasadena, CA 91125 (United States); Tomsick, J. A.; Boggs, S. E.; Craig, W. W. [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720-7450 (United States); Pottschmidt, K. [Center for Space Science and Technology, University of Maryland Baltimore County, Baltimore, MD 21250 (United States); Bhalerao, V. [Inter-University Center for Astronomy and Astrophysics, Post Bag 4, Ganeshkhind, Pune 411007 (India); Boirin, L. [Observatoire Astronomique de Strasbourg, 11 Rue de l' Université, F-67000 Strasbourg (France); Chakrabarty, D. [Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Christensen, F. E. [DTU Space, National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Degenaar, N. [Department of Astronomy, University of Michigan, 1085 South University Avenue, Ann Arbor, MI 48109 (United States); Fabian, A. C. [Institute of Astronomy, Madingley Road, Cambridge CB3 0HA (United Kingdom); Gandhi, P. [Department of Physics, Durham University, South Road, Durham DH1 3LE (United Kingdom); Göğüş, E. [Sabancı University, Orhanlı-Tuzla, İstanbul 34956 (Turkey); and others

    2015-05-01

    We report on a 10 ks simultaneous Chandra/High Energy Transmission Grating (HETG)–Nuclear Spectroscopic Telescope Array (NuSTAR) observation of the Bursting Pulsar, GRO J1744-28, during its third detected outburst since discovery and after nearly 18 yr of quiescence. The source is detected up to 60 keV with an Eddington persistent flux level. Seven bursts, followed by dips, are seen with Chandra, three of which are also detected with NuSTAR. Timing analysis reveals a slight increase in the persistent emission pulsed fraction with energy (from 10% to 15%) up to 10 keV, above which it remains constant. The 0.5–70 keV spectra of the persistent and dip emission are the same within errors and well described by a blackbody (BB), a power-law (PL) with an exponential rolloff, a 10 keV feature, and a 6.7 keV emission feature, all modified by neutral absorption. Assuming that the BB emission originates in an accretion disk, we estimate its inner (magnetospheric) radius to be about 4 × 10{sup 7} cm, which translates to a surface dipole field B ≈ 9 × 10{sup 10} G. The Chandra/HETG spectrum resolves the 6.7 keV feature into (quasi-)neutral and highly ionized Fe xxv and Fe xxvi emission lines. XSTAR modeling shows these lines to also emanate from a truncated accretion disk. The burst spectra, with a peak flux more than an order of magnitude higher than Eddington, are well fit with a PL with an exponential rolloff and a 10 keV feature, with similar fit values compared to the persistent and dip spectra. The burst spectra lack a thermal component and any Fe features. Anisotropic (beamed) burst emission would explain both the lack of the BB and any Fe components.

  4. Genreanalyse af Investor Relations Newsletters. En teoretisk og empirisk baseret genreanalyse af tyske Investor Relations nyhedsbreve med fokus på identifikation og adskillelse af funktionelle træk

    DEFF Research Database (Denmark)

    Pedersen, Anne Grethe Julius

    2007-01-01

    My PhD-thesis focuses on genre analysis within the field of German applied linguistics, with the emphasis on the identification of functional moves in Investor Relations (IR) newsletters from chemical companies in Germany. IR newsletters are offered as an email subscription-based service on corpo......My PhD-thesis focuses on genre analysis within the field of German applied linguistics, with the emphasis on the identification of functional moves in Investor Relations (IR) newsletters from chemical companies in Germany. IR newsletters are offered as an email subscription-based service...... on corporate websites and addressed primarily to investors. The aim of my PhD thesis is to propose an explanatory genre description of IR Newsletters concentrating on constitutive factors like contextual aspects incorporating communicative purposes, functional moves and lexicogrammatical features. The question...

  5. INTEGRAL Galactic bulge monitoring observations of GRO J1750-27 (AX J1749.1-2639), H1743-322 and SLX 1746-331

    DEFF Research Database (Denmark)

    Kuulkers, E.; Beckmann, V.; Shaw, S.;

    2008-01-01

    A new season of the INTEGRAL Galactic Bulge monitoring program (see ATels #438, #874, #1005; Kuulkers et al. 2007, A&A 466, 595) started, with observations on UT 11 Feb 2008, 16:33-18:07. We here report on results from three currently active transient sources. The IBIS/ISGRI and JEM-X1 images sho...... a bright source near GX 3+1, coincident with the position of the transient accreting X-ray pulsar GRO J1750-27 (AX J1749.1-2639)....

  6. FGV/DAPP lança newsletter semanal com análises de rede e de políticas públicas

    OpenAIRE

    Ferreira, Humberto

    2014-01-01

    A Diretoria de Análise de Políticas Públicas lançou nesta segunda-feira (18) a DAPP Notícias, newsletter com periodicidade semanal que oferecerá análises de rede e de políticas públicas realizadas por sua equipe

  7. Final Technical Progress Report; Closeout Certifications; CSSV Newsletter Volume I; CSSV Newsletter Volume II; CSSV Activity Journal; CSSV Final Financial Report

    Energy Technology Data Exchange (ETDEWEB)

    Houston, Johnny L [PI; Geter, Kerry [Division of Business and Finance

    2013-08-23

    This Project?s third year of implementation in 2007-2008, the final year, as designated by Elizabeth City State University (ECSU), in cooperation with the National Association of Mathematicians (NAM) Inc., in an effort to promote research and research training programs in computational science ? scientific visualization (CSSV). A major goal of the Project was to attract the energetic and productive faculty, graduate and upper division undergraduate students of diverse ethnicities to a program that investigates science and computational science issues of long-term interest to the Department of Energy (DoE) and the nation. The breadth and depth of computational science?scientific visualization and the magnitude of resources available are enormous for permitting a variety of research activities. ECSU?s Computational Science-Science Visualization Center will serve as a conduit for directing users to these enormous resources.

  8. Department of Energy Awards $43 Million to Spur Offshore Wind Energy, Wind Program Newsletter, September 2011 Edition (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-09-01

    EERE Wind Program Quarterly Newsletter - September 2011. In September, the U.S. Department of Energy announced that it will award $43 million over the next five years to 41 projects across 20 states to speed technical innovations, lower costs, and shorten the timeline for deploying offshore wind energy systems. The projects will advance wind turbine design tools and hardware, improve information about U.S. offshore wind resources, and accelerate the deployment of offshore wind by reducing market barriers such as supply chain development, transmission and infrastructure. The projects announced in September focus on approaches to advancing offshore technology and removing market barriers to responsible offshore wind energy deployment. Funding is subject to Congressional appropriations.

  9. Strontium-Substituted Bioceramics Particles: A New Way to Modulate MCP-1 and Gro-α Production by Human Primary Osteoblastic Cells

    Directory of Open Access Journals (Sweden)

    Julien Braux

    2016-12-01

    Full Text Available Background: To avoid morbidity and limited availability associated with autografts, synthetic calcium phosphate (CaP ceramics were extensively developed and used as bone filling materials. Controlling their induced-inflammatory response nevertheless remained a major concern. Strontium-containing CaP ceramics were recently demonstrated for impacting cytokines’ secretion pattern of human primary monocytes. The present study focuses on the ability of strontium-containing CaP to control the human primary bone cell production of two major inflammatory and pro-osteoclastogenic mediators, namely MCP-1 and Gro-α, in response to ceramics particles. Methods: This in vitro study was performed using human primary osteoblasts in which their response to ceramics was evaluated by PCR arrays, antibody arrays were used for screening and real-time PCR and ELISA for more focused analyses. Results: Study of mRNA and protein expression highlights that human primary bone cells are able to produce these inflammatory mediators and reveal that the adjunction of CaP in the culture medium leads to their enhanced production. Importantly, the current work determines the down-regulating effect of strontium-substituted CaP on MCP-1 and Gro-α production. Conclusion: Our findings point out a new capability of strontium to modulate human primary bone cells’ communication with the immune system.

  10. INTEGRAL detection of the on-going outbursts from 1RXS J180408.9-342058 and GRO J1750-27

    DEFF Research Database (Denmark)

    Boissay, R.; Chenevez, J.; Wilms, J.

    2015-01-01

    During the observations of the Galactic Center (from 2015 February 16 12:46 to February 17 at 4:25 UTC), INTEGRAL detected the two sources 1RXS J180408.9-342058 (Atel #6997, #7008, #7039) and GRO J1750-27 (Atel #1385, #1400, #6839) which were recently reported to undergo new outbursts. 1RXS J180408.......9-342058 was observed in both the IBIS/ISGRI and the JEM-X FoV. A preliminary analysis of the ISGRI and JEM-X data revealed that the source broad-band spectrum (effective exposure time 34.2 ks for ISGRI and 9.3 ks for the two JEM-X) could be described by using a cut-off power-law model. We measured a power-law photon...... of the source. GRO J1750-27 was observed by IBIS/ISGRI for an effective exposure time 34.2 ks and by the two JEM-X for a total effective exposure time 9 ks. The ISGRI spectrum of the source could be roughly described with a soft power-law of photon index ~4. The estimated source flux from the spectral fit is 7...

  11. Application of a relativistic accretion disc model to X-ray spectra of LMC X-1 and GRO J1655-40

    CERN Document Server

    Gierlinski, M; Ebisawa, K; Gierlinski, Marek; Maciolek-Niedzwiecki, Andrzej; Ebisawa, Ken

    2001-01-01

    We present a general relativistic accretion disc model and its application to the soft-state X-ray spectra of black hole binaries. The model assumes a flat, optically thick disc around a rotating Kerr black hole. The disc locally radiates away the dissipated energy as a blackbody. Special and general relativistic effects influencing photons emitted by the disc are taken into account. The emerging spectrum, as seen by a distant observer, is parametrized by the black hole mass and spin, the accretion rate, the disc inclination angle and the inner disc radius. We fit the ASCA soft state X-ray spectra of LMC X-1 and GRO J1655-40 by this model. We find that having additional limits on the black hole mass and inclination angle from optical/UV observations, we can constrain the black hole spin from X-ray data. In LMC X-1 the constrain is weak, we can only rule out the maximally rotating black hole. In GRO J1655-40 we can limit the spin much better, and we find 0.68 < a < 0.88. Accretion discs in both sources a...

  12. Development of PCR primers and a DNA macroarray for the simultaneous detection of major Staphylococcus species using groESL gene.

    Science.gov (United States)

    Chiang, Yu-Cheng; Lu, Hsi-Chi; Li, Sheng-Chih; Chang, Yu-Hsin; Chen, Hsin-Yen; Lin, Chia-Wei; Tsen, Hau-Yang

    2012-03-01

    Staphylococcus spp., including S. aureus, S. intermedius, S. hyicus, S. epidermidis, S. saprophyticus, S. haemolyticus, S. xylosus, and S. carnosus, are major bacterial species associated with food poisoning, and human and veterinary clinics. Traditional methods for the identification of these staphylococci are time-consuming, laborious, or inaccurate. Therefore, rapid and accurate diagnostic methods are needed. In this study, we designed the DNA probes and polymerase chain reaction (PCR) primers for the detection of the aforementioned Staphylococcus species. These primers were proved to be specific for the detection of their corresponding target strains. Furthermore, by using a consensus primer pair, we were able to co-amplify the intergenic region of groES-groEL for these staphylococci. Followed by a chromogenic macroarray system with the specific probes on the plastic chips, these staphylococci in milk products or clinical samples could be simultaneously detected. When the system was used for the inspection of milk or urine samples containing N × 10⁰ target cells per milliliter of the sample, all these staphylococcal species could be identified after an 8-h pre-enrichment step. This system also allowed the adequate diagnosis of bacteremia, since N × 10⁰ target cells per milliliter of the blood samples could be detected after a 12-h pre-enrichment. Compared to the multiplex PCR method, this approach has the additional advantage that it allowed the discrimination of more bacterial strains-even some bacterial strains that may generate PCR products with the same molecular sizes.

  13. Genreanalyse af Investor Relations Newsletters. En teoretisk og empirisk baseret genreanalyse af tyske Investor Relations nyhedsbreve med fokus på identifikation og adskillelse af funktionelle træk

    DEFF Research Database (Denmark)

    Pedersen, Anne Grethe Julius

    2007-01-01

    on corporate websites and addressed primarily to investors. The aim of my PhD thesis is to propose an explanatory genre description of IR Newsletters concentrating on constitutive factors like contextual aspects incorporating communicative purposes, functional moves and lexicogrammatical features. The question......My PhD-thesis focuses on genre analysis within the field of German applied linguistics, with the emphasis on the identification of functional moves in Investor Relations (IR) newsletters from chemical companies in Germany. IR newsletters are offered as an email subscription-based service...

  14. National Bioenergy Center, Biochemical Platform Integration Project: Quarterly Update, Winter 2011-2012 (Newsletter)

    Energy Technology Data Exchange (ETDEWEB)

    2012-04-01

    Winter 2011-2012 issue of the National Bioenergy Center Biochemical Platform Integration Project quarterly update. Issue topics: 34th Symposium on Biotechnology for Fuels and Chemicals; feasibility of NIR spectroscopy-based rapid feedstock reactive screening; demonstrating integrated pilot-scale biomass conversion. The Biochemical Process Integration Task focuses on integrating the processing steps in enzyme-based lignocellulose conversion technology. This project supports the U.S. Department of Energy's efforts to foster development, demonstration, and deployment of 'biochemical platform' biorefineries that economically produce ethanol or other fuels, as well as commodity sugars and a variety of other chemical products, from renewable lignocellulosic biomass.

  15. Senate Rostrum: The Newsletter of the Academic Senate for California Community Colleges, March 2009

    Science.gov (United States)

    Academic Senate for California Community Colleges, 2009

    2009-01-01

    The Rostrum is a quarterly publication of the academic senate for California community colleges. The following articles are included in this issue: (1) Establishing a Systemwide California Community College General Education Advanced Placement (CCC GE AP) List by Dave Degroot; (2) Explaining the ASCCC Position on "Transfer Degrees" by…

  16. Bond Issues.

    Science.gov (United States)

    Pollack, Rachel H.

    2000-01-01

    Notes trends toward increased borrowing by colleges and universities and offers guidelines for institutions that are considering issuing bonds to raise money for capital projects. Discussion covers advantages of using bond financing, how use of bonds impacts on traditional fund raising, other cautions and concerns, and some troubling aspects of…

  17. Newspaper Issue.

    Science.gov (United States)

    Bourke, Thomas A.; And Others

    1986-01-01

    This special issue includes "The Microfilming of Newspapers: An Overview" (Thomas Bourke); "United States Newspaper Program: Progress and Propsects" (Larry Sullivan); "The Preservation of Canadian Newspapers" (Mary Jane Starr); "Current Filming of the New York Times at UMI" (Kenneth Tillman); and "The…

  18. New England Wind Forum: A Wind Powering America Project; Volume 1, Issue 2 -- December 2006

    Energy Technology Data Exchange (ETDEWEB)

    Grace, R. C.; Gifford, J.

    2006-12-01

    The New England Wind Forum electronic newsletter summarizes the latest news in wind energy development activity, markets, education, and policy in the New England region. It also features an interview with a key figure influencing New England's wind energy development. Volume 1, Issue 2 features an interview with John MacLeod of Hull Municipal Light Plant. Hull 2, a 1.8-MW Vestas turbine installed in the Town of Hull in Massachusetts in 2006, is the largest wind turbine in New England and the first U.S. installation on a capped landfill.

  19. Paul Scherrer Institut annual report 1996. Annex I. PSI-F1-Newsletter 1996 nuclear and particle physics. Muons in solid-state physics and chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Herlach, D.; Kettle, P.R.; Buechli, C. [eds.] [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-02-01

    This newsletter contains reports from the F1-Department and its Divisions. The contributions are categorized as follows: - activities of the F1-Department of PSI, - nuclear and particle physics supported by the Department, -applications of muons in solid-state physics and chemistry. Groups were asked to present new, preliminary or final results obtained in 1996, as well as a publication list, related to F1-supported work which had appeared in scientific journals during 1996. (author) figs., tabs., refs.

  20. Paul Scherrer Institut annual report 1995. Annex I: PSI-F1-Newsletter 1995. Nuclear and particle physics. Muons in solid-state physics and chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Herlach, D.; Kettle, P.R. [eds.

    1996-09-01

    This newsletter contains reports from the F1-Department and its Divisions. The contributions are categorized as follows: - activities of the F1-Department of PSI, - nuclear and particle physics supported by the Department, - applications of muons in solid-state physics and chemistry. Groups were asked to present new, preliminary or final results obtained in 1995, as well as a publication list, related to F1-supported work which had appeared in scientific journals during 1995. (author) figs., tabs., refs.

  1. Theoretical Issues

    Energy Technology Data Exchange (ETDEWEB)

    Marc Vanderhaeghen

    2007-04-01

    The theoretical issues in the interpretation of the precision measurements of the nucleon-to-Delta transition by means of electromagnetic probes are highlighted. The results of these measurements are confronted with the state-of-the-art calculations based on chiral effective-field theories (EFT), lattice QCD, large-Nc relations, perturbative QCD, and QCD-inspired models. The link of the nucleon-to-Delta form factors to generalized parton distributions (GPDs) is also discussed.

  2. A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer.

    Science.gov (United States)

    Wang, Bo; Khachigian, Levon M; Esau, Luke; Birrer, Michael J; Zhao, Xiaohang; Parker, M Iqbal; Hendricks, Denver T

    2009-05-01

    Although early growth response-1 (EGR-1) has been shown as a key transcription factor in controlling cell growth, proliferation, differentiation, and angiogenesis, its role in the development of esophageal cancer is poorly understood despite the high frequency of this disease in many parts of the world. Here, immunohistochemistry showed that EGR-1 is overexpressed in 80% of esophageal tumor tissues examined. Furthermore, EGR-1 is constitutively expressed in all esophageal cancer cell lines analyzed. Esophageal squamous carcinoma WHCO1 cells stably transfected with EGR-1 short hairpin RNA displayed a 55% reduction in EGR-1 protein levels, 50% reduction in cell proliferation, a 50% reduction in cyclin-dependent kinase 4 levels, and a 2-fold induction in p27(Kip1) levels associated with a G(2)-M cell cycle arrest. EGR-1 knockdown also caused a marked induction in IkappaBalpha expression, an effect also observed in GRObeta RNA interference-expressing WHCO1 cells, because EGR-1 lies downstream of GRO/CXCR2 signaling. Furthermore, p65 mRNA levels were also reduced in cells treated with either short hairpin RNA EGR-1 or small interfering RNA EGR-1. Immunohistochemical analysis indicated that p65 is elevated in 78% (n = 61) of esophageal tumor sections analyzed. Moreover, nuclear factor-kappaB inhibition with either sodium salicylate or p65 RNA interference led to a significant reduction in GROalpha and GRObeta expression. These results indicate that EGR-1 and nuclear factor-kappaB mediate GRO/CXCR2 proliferative signaling in esophageal cancer and may represent potential target molecules for therapeutic intervention.

  3. The immobilization of heavy metals in soil by bioaugmentation of a UV-mutant Bacillus subtilis 38 assisted by NovoGro biostimulation and changes of soil microbial community

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ting [MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300071 (China); Urban Transport Emission Control Research Centre, College of Environmental Science and Engineering, Nankai University, Tianjin 300071 (China); Sun, Hongwen, E-mail: sunhongwen@nankai.edu.cn [MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300071 (China); Mao, Hongjun [Urban Transport Emission Control Research Centre, College of Environmental Science and Engineering, Nankai University, Tianjin 300071 (China); Zhang, Yanfeng; Wang, Cuiping; Zhang, Zhiyuan; Wang, Baolin; Sun, Lei [MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300071 (China)

    2014-08-15

    Highlights: • A UV-mutated species, Bacillus subtilis 38, is a good sorbent for multi-metals (Cd, Cr, Hg and Pb). • B38 mixed with NovoGro exhibited a synergetic effect on the immobilization of heavy metals in soil. • DTPA, M3 and BCR were suitable for predicting metal bioavailability for specific classes of plant. • The NovoGro could enhance the proliferation of both exotic B38 and native microbes. • It's a practical strategy for the remediation of actual farmland polluted by multi-heavy metals. - Abstract: Bacillus subtilis 38 (B38) is a mutant species of Bacillus subtilis acquired by UV irradiation with high cadmium tolerance. This study revealed that B38 was a good biosorbent for the adsorption of multiple heavy metals (cadmium, chromium, mercury, and lead). Simultaneous application of B38 and NovoGro (SNB) exhibited a synergetic effect on the immobilization of heavy metals in soil. The heavy metal concentrations in the edible part of the tested plants (lettuce, radish, and soybean) under SNB treatment decreased by 55.4–97.9% compared to the control. Three single extraction methods, diethylenetriaminepentaacetic acid (DTPA), Mehlich 3 (M3), and the first step of the Community Bureau of Reference method (BCR1), showed good predictive capacities for metal bioavailability to leafy, rhizome, and leguminous plant, respectively. The polymerase chain reaction–denaturing gradient gel electrophoresis (PCR–DGGE) profiles revealed that NovoGro could enhance the proliferation of both exotic B38 and native microbes. Finally, the technology was checked in the field, the reduction in heavy metal concentrations in the edible part of radish was in the range between 30.8% and 96.0% after bioremediation by SNB treatment. This study provides a practical strategy for the remediation of farmland contaminated by multiple heavy metals.

  4. Wind, jet, hybrid corona and hard X-ray flares: multiwavelength evolution of GRO J1655-40 during the 2005 outburst rise

    CERN Document Server

    Kalemci, E; Maccarone, T J; Dincer, T; Russell, T D; Bailyn, C; Tomsick, J A

    2016-01-01

    We have investigated the complex multiwavelength evolution of GRO J1655-40 during the rise of its 2005 outburst. We detected two hard X-ray flares, the first one during the transition from the soft state to the ultra-soft state, and the second one in the ultra-soft state. The first X-ray flare coincided with an optically thin radio flare. We also observed a hint of increased radio emission during the second X-ray flare. To explain the hard flares without invoking a secondary emission component, we fit the entire data set with the eqpair model. This single, hybrid Comptonization model sufficiently fits the data even during the hard X-ray flares if we allow reflection fractions greater than unity. In this case, the hard X-ray flares correspond to a Comptonizing corona dominated by non-thermal electrons. The fits also require absorption features in the soft and ultra-soft state which are likely due to a wind. In this work we show that the wind and the optically thin radio flare co-exist. Finally, we have also in...

  5. Using GRO J1655-40 to test Swift/BAT as a monitor for bright hard X-ray sources

    CERN Document Server

    Senziani, F; De Luca, A; Caraveo, P A; Belloni, T; Bignami, Giovanni Fabrizio

    2007-01-01

    While waiting for new gamma-ray burst detections, the Burst Alert Telescope (BAT) on board Swift covers each day ~50% of the sky in the hard X-ray band (``Survey data''). The large field of view (FOV), high sensitivity and good angular resolution make BAT a potentially powerful all-sky hard X-ray monitor, provided that mask--related systematics can be properly accounted for. We have developed and tested a complete procedure entirely based on public Swift/BAT software tools to analyse BAT Survey data, aimed at assessing the flux and spectral variability of bright sources in the 15-150 keV energy range. Detailed tests of the capabilities of our procedure were performed focusing, in particular, on the reliability of spectral measurements over the entire BAT FOV. First, we analyzed a large set of Crab observations, spread over ~7 months. Next, we studied the case of GRO J1655-40, a strongly variable source, which experienced a 9-month long outburst, beginning on February 2005. Such an outburst was systematically ...

  6. A target-oriented magnetotelluric inversion approach for characterizing the low enthalpy Groß Schönebeck geothermal reservoir

    Science.gov (United States)

    Muñoz, G.; Ritter, O.; Moeck, I.

    2010-12-01

    Electrical conductivity is a key parameter for the exploration and characterization of geothermal reservoirs as hot mineralized formation water of active geothermal areas usually exhibits significantly higher conductivity than the surrounding host rock. Here we present results of a magnetotelluric (MT) exploration experiment carried out in the vicinity of the Groß Schönebeck geothermal test site in Northern Germany, where a doublet system of two 4.3-km deep boreholes was drilled to establish an in situ laboratory to investigate the potential for geothermal energy production. Classical 2-D smooth inversion of the MT data, recorded along two profiles, reveals a shallow conductive structure in good agreement with information from regional geology and seismic images. However, at the northernmost part of the profiles, the conductivity models reveal deep-reaching conductive structures, which appear uncorrelated with existing (geophysical or geological) data. Incorporating information from seismics as independent constraints for MT inversions allows us to examine the model space rigorously but target oriented. Employing so-called tear-zone inversions we can effectively derive an alternative class of models, which are consistent with the MT observations but also with the other data sets. We speculate that the zones of high conductivity imaged at reservoir depth are related areas of reduced thickness of the overlaying evapourite layer. The enhanced conductivity can be explained by a higher fracture density in anhydritic layers and/or generally lower resistivity of the pore fluid.

  7. Evidence for a change in the radiation mechanism in the hard state of GRO J1655-40. Hysteresis in the broad-band noise components

    CERN Document Server

    Reig, P; Sobolewska, M A; Malzac, J

    2013-01-01

    We have analysed RXTE archival data to study the aperiodic variability of the black-hole binary GRO J1655-40 during the hard state of the 2005 outburst. We computed the 0.008-64 Hz power spectral density during the rise and decay of the 2005 outburst, and we found that they were reasonably well modelled by the sum of two, broad Lorenztian functions in most cases (plus a narrow QPO) which correspond to three different variability components. Our aim is to study the evolution of the timing properties of the source during the outburst, by studying the correlation between the characteristics of the broad-band noise components in the power spectra and the source luminosity. Our results suggest that the whole power spectrum shifts to high (low) frequencies as the source luminosity increases (decreases), in agreement with previous studies of other black hole binaries. However, we also detect a strong "hysteresis" pattern in the "frequency-luminosity" plots, and show that the "critical" luminosity limit, above which ...

  8. Wind, jet, hybrid corona and hard X-ray flares: multiwavelength evolution of GRO J1655-40 during the 2005 outburst rise

    Science.gov (United States)

    Kalemci, E.; Begelman, M. C.; Maccarone, T. J.; Dinçer, T.; Russell, T. D.; Bailyn, C.; Tomsick, J. A.

    2016-11-01

    We have investigated the complex multiwavelength evolution of GRO J1655-40 during the rise of its 2005 outburst. We detected two hard X-ray flares, the first one during the transition from the soft state to the ultra-soft state, and the second one in the ultra-soft state. The first X-ray flare coincided with an optically thin radio flare. We also observed a hint of increased radio emission during the second X-ray flare. To explain the hard flares without invoking a secondary emission component, we fit the entire data set with the eqpair model. This single, hybrid Comptonization model sufficiently fits the data even during the hard X-ray flares if we allow reflection fractions greater than unity. In this case, the hard X-ray flares correspond to a Comptonizing corona dominated by non-thermal electrons. The fits also require absorption features in the soft and ultra-soft state which are likely due to a wind. In this work we show that the wind and the optically thin radio flare co-exist. Finally, we have also investigated the radio to optical spectral energy distribution, tracking the radio spectral evolution through the quenching of the compact jet and rise of the optically thin flare, and interpreted all data using state transition models.

  9. Extended abstracts from the eight international meeting on progress in radio-oncology (ICRO/OeGRO 8), Salzburg, May 16-19, 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-12-15

    This part of the journal includes 25 extended abstracts from the Eight International Meeting on Progress in Radio-Oncology ICRO/OeGRO8 in Salzburg, Austria (May 16-19, 2007): adaptive radiotherapy of prostate cancer; homoradiation of prostate cancer; radiation therapy, chemotherapy and combined chemoradiation in the management of malignant glioma; return of high-dose per fraction radiotherapy: paradigm change, lesson from the past; from bench to bedside: enhancing the effects of radiotherapy through biological escalation; gastric cancer: MAGIC or Macdonald; analysis of set-up errors in 70 consecutive patients treated for rectal carcinoma; molecular targeted therapy; teleradiooncology: telematics applications in therapeutic radiology and oncology; in-room guidance technologies for adaptive radiotherapy; dose escalation with photons - emerging technologies; late side-effects after pelvic irradiation; a frameless robotic stereotactic system for highly focused extracranial radiotherapy; altered fractionation in head and neck tumors: an alternative to chemotherapy; integration of molecular targeting with radiotherapy; OGRT pf prostate cancer patients based on CBCT and kV images; hyperfractionation in medulloblastoma; re-irradiation of recurrent prostate cancer; dose reduction of radiotherapy in early-stage testicular semimoma; photons versus protons; randomized clinical trials on postoperative radiotherapy for high-risk head and neck cancer; cardiac risk in multimodal breast cancer treatment; the use of hyperthermia treatment planning in clinical practice; presentation of the ICRU-IAEA Joint Report 'prescribing, recording, and reporting proton-beam therapy'.

  10. Co-administration of rIpaB domain of Shigella with rGroEL of S. Typhi enhances the immune responses and protective efficacy against Shigella infection.

    Science.gov (United States)

    Chitradevi, Sekar Tamil Selvi; Kaur, Gurpreet; Uppalapati, Sivaramakrishna; Yadav, Anandprakash; Singh, Dependrapratap; Bansal, Anju

    2015-11-01

    Shigella species cause severe bacillary dysentery in humans and are associated with high morbidity and mortality. The Invasion plasmid antigen (IpaB) protein, which is conserved across all Shigella spp., induces macrophage cell death and is required to invade host cells. The present study evaluates the immunogenicity and protective efficacy of the recombinant (r) domain region of IpaB (rIpaB) of S. flexneri. rIpaB was administered either alone or was co-administered with the rGroEL (heat shock protein 60) protein from S. Typhi as an adjuvant in a mouse model of intranasal immunization. The IpaB domain region (37 kDa) of S. flexneri was amplified from an invasion plasmid, cloned, expressed in BL21 Escherichia coli cells and purified. Immunization with the rIpaB domain alone stimulated both humoral and cell-mediated immune responses. Furthermore, robust antibody (IgG, IgA) and T-cell responses were induced when the rIpaB domain was co-administered with rGroEL. Antibody isotyping revealed higher IgG1 and IgG2a antibody titers and increased interferon-gamma (IFN-γ) secretion in the co-administered group. Immunization of mice with the rIpaB domain alone protected 60%-70% of the mice from lethal infection by S. flexneri, S. boydii and S. sonnei, whereas co-administration with rGroEL increased the protective efficacy to 80%-85%. Organ burden and histopathological studies also revealed a significant reduction in lung infection in the co-immunized mice compared with mice immunized with the rIpaB domain alone. This study emphasizes that the co-administration of the rIpaB domain and rGroEL protein improves immune responses in mice and increases protective efficacy against Shigella infection. This is also the first report to evaluate the potential of the GroEL (Hsp 60) protein of S. Typhi as an adjuvant molecule, thereby overcoming the need for commercial adjuvants.

  11. Thermo-poroelastic numerical modelling for enhanced geothermal system performance: Case study of the Groß Schönebeck reservoir

    Science.gov (United States)

    Jacquey, Antoine B.; Cacace, Mauro; Blöcher, Guido; Watanabe, Norihiro; Huenges, Ernst; Scheck-Wenderoth, Magdalena

    2016-08-01

    Significant pressure and temperature changes can occur within geothermal reservoirs caused by injection and production of fluid which can affect transport properties of the rocks and therefore alter reservoir performance and sustainability. To understand the coupling between transport properties evolution and state variable changes, a complete description of the mechanical behavior of the reservoir is required which should consider thermo- and poroelastic effects. This study aims to integrate transport properties evolution for coupled thermo-hydro-mechanical (THM) process modelling of fluid-bearing reservoirs. This approach is here applied to the geothermal research site of Groß Schönebeck (40 km north of Berlin, Germany) which consists of a doublet system at a target depth of about - 4100 m in which both injection and production wells have been hydraulically stimulated. A 3D reservoir model including the main geological units, major natural fault zones and hydraulic fractures is integrated in the finite-element method-based simulator OpenGeoSys for modelling coupled THM processes during geothermal activity. One challenge of this study is to integrate both hydro-geological and physical complexity to better describe the dynamic behavior of the geothermal reservoir. From the results of the simulation, thermal breakthrough is observed after 18 years of injection and life time of the system has been evaluated as 50 years. Furthermore, a 5.5% increase of porosity around the injection well is observed as well as an increase of the anisotropy ratio for permeability (kz/kxy) of about 2%. These transport properties enhancements lead to a decrease of the thermal breakthrough time (around - 8%) and life time of the system (- 14%) compared to classic thermo-hydro simulations with constant transport properties. The results presented here provide therefore valuable insights for understanding porosity and permeability distributions and evolutions during injection and production

  12. About the Newsletter

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    The quarterly joumal “SHP NEWS” was firstly published on May, 1984 by HRC under the sponsorship of UNDP/UN-ESCAP-REDP (Regional Energy Development Program) in association with UNIDO. It was officially pemitted for publication with an ISSN No.O256-3118(International Standard Serial Number). The major objective of the journal is for constant exchange of information and experience in the small hydro power(SHP) section among Asian-Pacific countries and/or worldwide. The comprehensive coverage of“SHP NEWS”includes:

  13. PUWORLD Newsletter Survey Questionnaire

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    1.How did you hear about Weekly Intelligence of PUWORLD?Subscription button(0)Magazine advertisement(0)Referral from a friend,relative or colleague(1)Clicked through an email,Linkedin,Twitter or Facebook(0)Others(0)

  14. PUWORLD Newsletter Survey Questionnaire

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>1.How did you hear about Weekly Intelligence of PUWORLD?Subscription button(0)Magazine advertisement(0)Referral from a friend,relative or colleague(1)Clicked through an email,Linkedin,Twitter or Facebook(0)Others(0)2.In which way(s)do you receive and read Weekly Intelligence of PUWORLD?Personal Computer(0)Mobile Phone(1)Pad(0)Others(0)

  15. Parkinson's Disease Foundation Newsletter

    Science.gov (United States)

    ... Patient Advocates Sign Up for Funding News npj Parkinson's Disease Scientific Advisory Board Understanding Parkinson's Coping with a Diagnosis What is Parkinson’s Disease? National HelpLine Educational Publications Online Seminars Parkinson's News ...

  16. South Pacific newsletter : 25

    OpenAIRE

    Kagoshima University Research Center for the Pacific Islands; カゴシマ ダイガク コクサイ トウショ キョウイク ケンキュウ センター; 鹿児島大学国際島嶼教育研究センター

    2014-01-01

    Expecting more extensive education and research activities in island areas / Shinichi Noda Yakushima : the island of hope / Herman Hidayat [International Symposium] Yanagida Kunio’s folklore, re-overlooking sea-road of the East Asia The power to change the island society: information and communications technology to promote the remote islands Keynote speech: does computerization of remote islands produce innovation? / Masato Yokoyama 1: Cloud computing and the increased ava...

  17. Field Verification Project for Small Wind Turbines, Quarterly Report: April - June 2001; 2nd Quarter, Issue No.5

    Energy Technology Data Exchange (ETDEWEB)

    2002-04-01

    This newsletter provides a brief overview of the Field Verification Project for Small Wind Turbines conducted out of the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  18. Field Verification Program for Small Wind Turbines, Quarterly Report: 3rd Quarter, Issue No.2, July-September 2000

    Energy Technology Data Exchange (ETDEWEB)

    Cardinal. J.; Tu, P.

    2001-05-16

    This newsletter provides a brief overview of the Field Verification Program for Small Wind Turbines conducted out of the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  19. Field Verification Project for Small Wind Turbines Quarterly Report; July-September 2001, 3rd Quarter, Issue#6

    Energy Technology Data Exchange (ETDEWEB)

    2003-04-01

    This newsletter provides a brief overview of the Field Verification Project for Small Wind Turbines conducted at the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  20. Field Verification Program for Small Wind Turbines: Quarterly Report for January-March 2001; 1st Quarter, Issue No.4

    Energy Technology Data Exchange (ETDEWEB)

    Forsyth, T.; Cardinal, J.

    2001-10-30

    This newsletter provides a brief overview of the Field Verification Program for Small Wind Turbines conducted out of the NWTC and a description of current activities. The newsletter also contains case studies of current projects.

  1. Style Congruency and Persuasion: A Cross-Cultural Study Into the Influence of Differences in Style Dimensions on the Persuasiveness of Business Newsletters in Great Britain and the Netherlands

    NARCIS (Netherlands)

    Hendriks, B.C.; Meurs, W.F.J. van; Korzilius, H.P.L.M.; Pair, R.G. le; Blanc-Damen, S. le

    2012-01-01

    Abstract—Research problem: The purpose of the present study was to investigate whether style congruency on the dimensions succinct-elaborate and instrumental-affective influenced the persuasiveness of business newsletters in the Netherlands and Great Britain. Research question: Is a writing style mo

  2. Comparison of the nucleotide sequences of 16S rRNA, 444 Ep-ank, and groESL heat shock operon genes in naturally occurring Ehrlichia equi and human granulocytic ehrlichiosis agent isolates from Northern California.

    Science.gov (United States)

    Chae, J S; Foley, J E; Dumler, J S; Madigan, J E

    2000-04-01

    We examined 11 naturally occurring isolates of Ehrlichia equi in horses and two human granulocytic ehrlichiosis agent isolates in California for sequence diversity in three genes. Ehrlichia equi isolates were from Sierra (n = 6), Mendocino (n = 3), Sonoma (n = 1), and Marin (n = 1) counties, and human granulocytic ehrlichiosis (HGE) agent isolates were obtained from Humboldt county. PCR with specific primers for 16S rRNA, 444 Ep-ank and groESL heat shock operon genes successfully produced amplicons for all 13 clinical samples. The 444 Ep-ank gene of the HGE agent and E. equi isolates from northern California is different from the eastern U.S. isolates BDS and USG3. The translated amino acid sequence of the groESL heat shock operon gene fragment is identical among E. equi, the HGE agent, and E. phagocytophila, with the exception of the northern Californian equine CASOLJ isolate. Microheterogeneity was observed in the 16S rRNA gene sequences of HGE agent and E. equi isolates from northern California. These results suggest that E. equi and the HGE agent found in California are similar or identical but may differ from the isolates of equine and human origin found in the eastern United States.

  3. The immobilization of heavy metals in soil by bioaugmentation of a UV-mutant Bacillus subtilis 38 assisted by NovoGro biostimulation and changes of soil microbial community.

    Science.gov (United States)

    Wang, Ting; Sun, Hongwen; Mao, Hongjun; Zhang, Yanfeng; Wang, Cuiping; Zhang, Zhiyuan; Wang, Baolin; Sun, Lei

    2014-08-15

    Bacillus subtilis 38 (B38) is a mutant species of Bacillus subtilis acquired by UV irradiation with high cadmium tolerance. This study revealed that B38 was a good biosorbent for the adsorption of multiple heavy metals (cadmium, chromium, mercury, and lead). Simultaneous application of B38 and NovoGro (SNB) exhibited a synergetic effect on the immobilization of heavy metals in soil. The heavy metal concentrations in the edible part of the tested plants (lettuce, radish, and soybean) under SNB treatment decreased by 55.4-97.9% compared to the control. Three single extraction methods, diethylenetriaminepentaacetic acid (DTPA), Mehlich 3 (M3), and the first step of the Community Bureau of Reference method (BCR1), showed good predictive capacities for metal bioavailability to leafy, rhizome, and leguminous plant, respectively. The polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) profiles revealed that NovoGro could enhance the proliferation of both exotic B38 and native microbes. Finally, the technology was checked in the field, the reduction in heavy metal concentrations in the edible part of radish was in the range between 30.8% and 96.0% after bioremediation by SNB treatment. This study provides a practical strategy for the remediation of farmland contaminated by multiple heavy metals. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Dental Issues & Down Syndrome

    Science.gov (United States)

    ... Associated Conditions » Dental Issues & Down Syndrome Dental Issues & Down Syndrome Dental care is important for everybody, but people ... is Different About the Teeth of People With Down Syndrome? Delayed Eruption The teeth of people with Down ...

  5. Sleep Issues and Sundowning

    Science.gov (United States)

    ... We will not sell or share your name. Sleep Issues and Sundowning Tweet Bookmark this page | Email | ... Sleep Changes Back to top Coping strategies for sleep issues and sundowning If the person is awake ...

  6. Seven Issues Revisited

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Whitehead, Jim; De Bra, Paul

    2002-01-01

    It has been 15 years since the original presentation by Frank Halasz at Hypertext'87 on seven issues for the next generation of hypertext systems. These issues are: Search and Query Composites Virtual Structures Computation in/over hypertext network Versioning Collaborative Work Extensibility...... and Tailorability Since that time, these issues have formed the nucleus of multiple research agendas within the Hypertext community. Befitting this direction-setting role, the issues have been revisited several times, by Halasz in his 1991 Hypertext keynote talk, and by Randy Trigg in his 1996 Hypertext keynote...... five years later. Additionally, over the intervening 15 years, many research systems have addressed the original seven issues, and new research avenues have opened up. The goal of this panel is to begin the process of developing a new set of seven issues for the next generation of hypertext system...

  7. Current issues and actions

    Energy Technology Data Exchange (ETDEWEB)

    Black, D.G.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the progress that has been made toward achieving full regulatory compliance at the Hanford Site. Ongoing compliance self-assessments, implementation of the Tri-Party Agreement, and public meetings continue to identify environmental compliance issues. These issues are discussed openly with the regulatory agencies and with the public to ensure that all environmental compliance issues are addressed.

  8. JPRS Report, Proliferation Issues

    Science.gov (United States)

    2016-03-24

    competence in handling delicate and agricultral projects, medical research, sterilizing issues. tools, and digging oilfields. Electricity Minister Engineer ...CONTENTS 21 October 1992 [This report contains foreign media information on issues related to worldwide proliferation and transfer activities in nuclear...be built by shipping plutonium through the Strait of Malacca, For- the year 2006 to meet the soaring electricity demand, eign Ministry officials said

  9. Medical Issues in Adoption

    Science.gov (United States)

    ... Teaching Kids to Be Smart About Social Media Medical Issues in Adoption KidsHealth > For Parents > Medical Issues in Adoption Print A A A What's ... some things to know about the health and medical care of an adopted child, before, during, and ...

  10. Editorial Introduction - Issue 5

    Directory of Open Access Journals (Sweden)

    Emily Lynema

    2008-12-01

    Full Text Available Welcome to the 5th issue of the Code4Lib Journal. We've come a long way in just over a year! We hope you take a few minutes to celebrate those accomplishments with us as you explore issue 5 and read about the innovations, ideas, and experiences shared there. Let's learn from each other.

  11. Ethical issues in genetics.

    Science.gov (United States)

    Shannon, T A

    1999-03-01

    The first section of the Notes on Moral Theology reviews ethical issues in genetics through the lenses of privacy-confidentiality; risk-benefit analysis in relation to prenatal diagnosis and gene therapy; and freedom-determinism/human dignity in the context of cloning. The author provides an overview of developments in genetics and highlights thematic issues common to these developments.

  12. Navigating "thorny" issues

    Science.gov (United States)

    Hutchinson, Kashema; Gilbert, Aderinsola; Malyukova, Anna

    2016-09-01

    In their article Mindfulness and discussing ` thorny' issues in the classroom Konstantinos Alexakos et al. (Cult Stud Sci Educ, 2016. doi: 10.1007/s11422-015-9718-0) describe "thorny" issues as "difficult topics to discuss because they are more personal to some perhaps even cause pain and violence." As women from different backgrounds, we engage in a metalogue, which expands on our thoughts and emotions the thorny issues evoked. Our discussion is grounded in theoretical frameworks of mindfulness, wellness, and safe space for learning. We also reflect on our experiences of facing some of the thorny issues in our academic and personal lives. Having trust and respect for one another and being aware of thorny issues allows for a meaningful conversation about the complexity and nuances involved in discussing difficult topics in a classroom setting.

  13. Understanding Pregnancy and Birth Issues

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Pregnancy and Birth Issues Past Issues / Winter 2008 Table ... turn Javascript on. What is a High-Risk Pregnancy? All pregnancies involve a certain degree of risk ...

  14. Assessment of Issue Handling Efficiency

    NARCIS (Netherlands)

    Luijten, B.; Visser, J.; Zaidman, A.

    2013-01-01

    We mined the issue database of GNOME to assess how issues are handled. How many issues are submitted and resolved? Does the backlog grow or decrease? How fast are issues resolved? Does issue resolution speed increase or decrease over time? In which subproject are issues handled most efficiently? To

  15. Assessment of Issue Handling Efficiency

    NARCIS (Netherlands)

    Luijten, B.; Visser, J.; Zaidman, A.

    2013-01-01

    We mined the issue database of GNOME to assess how issues are handled. How many issues are submitted and resolved? Does the backlog grow or decrease? How fast are issues resolved? Does issue resolution speed increase or decrease over time? In which subproject are issues handled most efficiently? To

  16. Special issue: Plasma Conversion

    NARCIS (Netherlands)

    Nozaki, T.; Bogaerts, A.; Tu, X.; van de Sanden, M. C. M.

    2017-01-01

    With growing concern of energy and environmental issues, the combination of plasma and heterogeneous catalysts receives special attention in greenhouse gas conversion, nitrogen fixation and hydrocarbon chemistry. Plasma gas conversion driven by renewable electricity is particularly important for the

  17. Research Article Special Issue

    African Journals Online (AJOL)

    2016-05-15

    May 15, 2016 ... entity which has various aims and uses various designs and plans to ... which exists in distribution systems, the possibility of error detection and its restoration .... To examine the issue of mobile agents security, two concepts ...

  18. Gambling: A Consumer Issue?

    Science.gov (United States)

    Makela, Carole J.; Tucker, Suzanne

    1993-01-01

    Focuses upon gambling, the twelfth largest industry in the United States, and its impact on families. Discusses the history of gambling, the cost of gambling, and the growth of lotteries. Suggests issues for consumer professionals to explore. (JOW)

  19. Pregnancy and Reproductive Issues

    Science.gov (United States)

    ... Relationships Pregnancy Share this page Facebook Twitter Email Pregnancy and Reproductive Issues Tahirah Diagnosed in 2003 Pregnancy ... in control groups without the disease. Effects of pregnancy on MS Before 1950, most women with MS ...

  20. Environmental Compliance Issue Coordination

    Science.gov (United States)

    An order to establish the Department of Energy (DOE) requirements for coordination of significant environmental compliance issues to ensure timely development and consistent application of Departmental environmental policy and guidance

  1. Research Article Special Issue

    African Journals Online (AJOL)

    2016-07-17

    Jul 17, 2016 ... Work environment in the organization is one of important issues that ... and their help we can create environments to help resolve problems in the workplace and ..... Entrepreneurship: 101 creative problem solving techniques.

  2. Ethical issues in immunisation.

    Science.gov (United States)

    Isaacs, David; Kilham, Henry; Leask, Julie; Tobin, Bernadette

    2009-01-29

    Discussions about current and future immunisation programmes raise novel questions about familiar ethical issues. Two sets of ethical issues dominate these discussions. The first is the issue of compulsory immunisation: what should be done about parents who fail to immunise their children? The second is: given competing demands on health care budgets, how should principles of justice in access and distribution inform vaccination programmes? This paper considers these two issues in the light of traditional ethical principles. With respect to the first, we argue that compulsion is justified only in cases in which we know with practical certainty that parental failure to immunise puts their own child or other children at high risk of severe illness. We also argue that the state should compensate those who suffer vaccine-related injury. With respect to the second, we claim that allocating resources according to health care need requires establishing priorities between public health programmes such as immunisation and other treatment programmes.

  3. Medical Issues: Nutrition

    Science.gov (United States)

    ... support & care > living with sma > medical issues > nutrition Nutrition Good nutrition is essential to health and growth. ... must make decisions based on their own needs. Nutrition Considerations Since we are still waiting for clinical ...

  4. Osteogenesis Imperfecta Issues: Constipation

    Science.gov (United States)

    OI Issues: Constipation 804 W. Diamond Ave., Ste. 210 Gaithersburg, MD 20878 (800) 981-2663 (301) 947-0083 Fax: (301) 947- ... a cure, education, awareness, and mutual support. Introduction Constipation is a problem for some people with osteogenesis ...

  5. Emerging Issues for Cultural Tourism in Macau Fragen des Kultur-Toursmus in Macau

    Directory of Open Access Journals (Sweden)

    Hilary du Cros

    2009-04-01

    Full Text Available Recent research on achieving sustainable heritage tourism in Macau advocates a greater collaboration between tourism and heritage management authorities and the local community on reaching sustainable tourism goals. A key theme for Macau in the last ten years has been how the tension between the proponents for greater casino development versus those for cultural heritage product development has played out in government policies for heritage management, private sector tourism development and host community concerns about heritage protection and achieving quality tourism. The indirect influence of the central government on Macau Special Administrative Region’s (SAR’s policy development in relation to these topics in the last ten years will be discussed in this context using findings from three recent studies by the Institute For Tourism Studies (IFT and background information collected on government policy and community views. This paper will outline emerging issues regarding demand, supply, and impacts of cultural tourism with reference to findings from four recent research projects. Special reference will be made to over-use and under-use issues, authenticity, and the management of tourism impacts while enhancing visitor experience. Strategic planning and management of cultural tourism products will also be touched upon. Jüngste Forschungen zum Kultur- und Denkmal-Tourismus in Macau haben ergeben, dass einer stärkeren Zusammenarbeit zwischen den Verwaltungsbereichen Toursmus und Denkmalpflege sowie den lokalen Gemeinden große Bedeutung zukommt, um eine nachhaltige Förderung der Tourismus zu erzielen.

  6. Volume 4, Issue 1

    Directory of Open Access Journals (Sweden)

    Karen Nelson

    2013-04-01

    Full Text Available This issue showcases a rich variety of first year issues reported from an assortment of national and international settings.  In the Feature, Professor Phil Long (University of Queensland and Associate Professor Shane Dawson (University of South Australia share their views about the issues and challenges associated with learning analytics.  Reflecting the adage from last century that successful student engagement is the result of a combination of warmth and challenge the articles and practice reports focus on both the cognitive challenge  (e.g., assessment, forms of knowledge, distance learning, research skills, peer learning, etc. and the affective warmth (e.g., help-seeking, collaboration, identity development etc. aspects of student behaviour.

  7. Volume 7 Issue 2

    Directory of Open Access Journals (Sweden)

    Tracy Creagh

    2016-07-01

    Full Text Available The continuing interest and commitment to improving the student experience in the tertiary sector was reflected in yet another successful Students, Transitions, Achievement, Retention and Success (STARS Conference recently held in Perth, Western Australia (June 29-July 2, 2016.  As is customary, this issue of the journal publishes the top research papers selected via a peer review process and the top Emerging Initiatives selected by the Conference Committee.  As well, a Good Practice Report was selected for this issue.  The Invited Feature in this issue republishes an article from Professor Sally Kift, President of the Australian Learning and Teaching Fellows (and one of the Editors of Student Success. The statement draws on and is representative of the national reaction to the closure of the OLT, highlighting the substantial role it has played in developing and disseminating innovation and good practice in tertiary teaching and learning.

  8. Year 2000 commercial issues

    Energy Technology Data Exchange (ETDEWEB)

    Kratz, M.P.J.; Booth, R.T. [Bennett Jones, Calgary, AB (Canada)

    1998-12-31

    This presentation focused on commercial aspects of the Y2K including: (1) special communication issues, (2) outsourcing transactions, (3) joint ventures and the significance for the oil and gas industry, and (4) contingency planning. Communication issues involve interaction with suppliers and vendors of critical systems, liability for Y2K communications (misrepresentation, defamation, promissory estoppel, statutory liability), securities disclosure (Canadian and US SEC requirements), protected communications, protection for Year 2000 statements. Outsourcing problems highlighted include resistance of suppliers to assume responsibility for Y2K problem remediation, factors which support and negate supplier responsibility, scope of suppliers` obligation, and warranties in respect of third party software. Regarding joint ventures, questions concerning limitations on liability, supply warranties, stand-by arrangements, stockpiling inventory, indemnities, confidentiality, operator compensation versus operator risk, and insurance were raised and addressed. Among contingency planning issues the questions of Y2K legal audit, and disclosure aspects of contingency planning were the featured concerns. figs.

  9. SPECIAL ISSUE EDITORIAL

    Institute of Scientific and Technical Information of China (English)

    Amy J.C.TRAPPEY; Fataneh Taghaboni DUTTA; Kai-Ying CHEN

    2010-01-01

    @@ This special issue of Journal of Systems Science and Systems Engineering recognizes the contributions of authors and participants in the 16th ISPE International Conference on Concurrent Engineering (CE2009), 2009 ASME International Manufacturing - Science and Engineering Conference (MSEC) and 2009 IEEE International Conference on Systems, Man and Cybernetics. Among related papers presented in these conferences, the guest editors have selectively identified and invited the authors to re-write and extend their works to full-length papers for re-submission to the special issue.

  10. Phospholipase D from Loxosceles laeta Spider Venom Induces IL-6, IL-8, CXCL1/GRO-α, and CCL2/MCP-1 Production in Human Skin Fibroblasts and Stimulates Monocytes Migration

    Directory of Open Access Journals (Sweden)

    José M. Rojas

    2017-04-01

    Full Text Available Cutaneous loxoscelism envenomation by Loxosceles spiders is characterized by the development of a dermonecrotic lesion, strong inflammatory response, the production of pro-inflammatory mediators, and leukocyte migration to the bite site. The role of phospholipase D (PLD from Loxosceles in the recruitment and migration of monocytes to the envenomation site has not yet been described. This study reports on the expression and production profiles of cytokines and chemokines in human skin fibroblasts treated with catalytically active and inactive recombinant PLDs from Loxosceles laeta (rLlPLD and lipid inflammatory mediators ceramide 1-phosphate (C1P and lysophosphatidic acid (LPA, and the evaluation of their roles in monocyte migration. Recombinant rLlPLD1 (active and rLlPLD2 (inactive isoforms induce interleukin (IL-6, IL-8, CXCL1/GRO-α, and CCL2/monocyte chemoattractant protein-1 (MCP-1 expression and secretion in fibroblasts. Meanwhile, C1P and LPA only exhibited a minor effect on the expression and secretion of these cytokines and chemokines. Moreover, neutralization of both enzymes with anti-rLlPLD1 antibodies completely inhibited the secretion of these cytokines and chemokines. Importantly, conditioned media from fibroblasts, treated with rLlPLDs, stimulated the transmigration of THP-1 monocytes. Our data demonstrate the direct role of PLDs in chemotactic mediator synthesis for monocytes in human skin fibroblasts and indicate that inflammatory processes play an important role during loxoscelism.

  11. About this issue

    Directory of Open Access Journals (Sweden)

    Diane Mulligan

    2013-05-01

    Full Text Available I am delighted to have been asked to be the consulting editor for this special issue on disability and diversity. It covers a range of interesting articles that are relevant for anybody working in community eye health specifically, as well as in the health sector generally.

  12. A dividing issue

    DEFF Research Database (Denmark)

    Gamborg, Christian; Jensen, Frank Søndergaard; Sandøe, Peter

    2016-01-01

    . While there was broad agreement across all three groups that recreational hunting of naturally occurring “surplus” wildlife is acceptable, the release of farm-reared game birds for shooting was a dividing issue, both within the groups and between them. The majority of participants (51%) in the survey...

  13. Algeria: Current Issues

    Science.gov (United States)

    2011-04-13

    exports and a concomitant drop in revenues. An International Monetary Fund (IMF) evaluation in December 2010 concluded that the government’s expansionary ... Policy , coordinated by John Rollins. President Bouteflika’s tenure has produced an energized foreign policy . Strains in ties with neighboring Morocco...Issues for U.S. Policy ............................................................................................................3 Background

  14. Introduction: The Transparency Issue

    NARCIS (Netherlands)

    Teurlings, J.; Stauff, M.

    2014-01-01

    Besides giving an overview on the individual contributions, this introduction to the special issue on transparency delineates a conceptual context for a critical analysis of the contemporary discourse on transparency and the media mechanisms related to it. It focuses on three ambivalences inherent t

  15. Structuralist Performance Issue.

    Science.gov (United States)

    Kirby, Michael, Ed.

    1979-01-01

    Defining structuralism as an unannounced aesthetic movement that involves not only the theatre but all arts, this journal issue focuses on structuralist performance. The nine articles provide information on the following topics: the French theatre group, Atelier Theatre et Musique; "Tell Me," a play by Guy de Cointet; patterning in "Five…

  16. Workplace Diversity Issues.

    Science.gov (United States)

    1999

    This document contains three symposium papers on workplace diversity issues. "Expanding Theories of Career Development: Adding the Voices of African American Women in the White Academy" (Mary V. Alfred) questions the validity of existing career development models for women and minority groups and examines the professional development of five…

  17. JPRS Report, Proliferation Issues

    Science.gov (United States)

    2016-03-24

    All information has been obtained from foreign radio and television broadcasts, news agency transmissions, newspapers , books, and periodicals. Items...COMMERCE 8NATIONAL TECHNICAL INFORMATION SERVICE ’TIC Q.,’U ’ SPRINGFIELD, VA. 22161 PROLIFERATION ISSUES JPRS-TND-92-023 CONTENTS 16 July 1992 [This...Experts To Tour Azerbaijan ........................................................................................ 12 To Conduct Biochemical Analysis

  18. Introduction to special issue

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Eisinga (Rob)

    2001-01-01

    textabstractIntroduces a series of articles on the analysis of cross sections. Issues involved in the analysis of time-series-cross-section (TSCS) data; Modeling of spatial effects, heterogeneity and TSCS data; Use of the Markov chain Monte Carlo and non-linear least-square methods for ecological in

  19. issue 4 2008.indb

    African Journals Online (AJOL)

    Cervical cancer is caused by a virus called Human Papilloma. Virus (HPV) ... protecting against the most common cancer causing HPV types (HPV 16 and 18), and one ..... is not just a woman's issue; men should also play a supportive role as ...

  20. PKI Scalability Issues

    OpenAIRE

    Slagell, Adam J; Bonilla, Rafael

    2004-01-01

    This report surveys different PKI technologies such as PKIX and SPKI and the issues of PKI that affect scalability. Much focus is spent on certificate revocation methodologies and status verification systems such as CRLs, Delta-CRLs, CRS, Certificate Revocation Trees, Windowed Certificate Revocation, OCSP, SCVP and DVCS.

  1. International Issues in Education

    Science.gov (United States)

    Ruggeri, Kai; Diaz, Carmen; Kelley, Karl; Papousek, Ilona; Dempster, Martin; Hanna, Donncha

    2008-01-01

    Anxiety, negative attitudes, and attrition are all issues presented in the teaching of statistics to undergraduates in research-based degrees regardless of location. Previous works have looked at these obstacles, but none have consolidated a multilingual, multinational effort using a consistent method. Over 400 Spanish-, English-, and…

  2. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-09-23

    meeting the government after reports that theCarlos Sofia and Carlos Machado , both national depu- United States, New Zealand, Australia and other...criticized the German Government for refusing to issue warth Gunther chairman of the Humanitarian Assis - the necessary export licenses to complete the

  3. Structuralist Performance Issue.

    Science.gov (United States)

    Kirby, Michael, Ed.

    1979-01-01

    Defining structuralism as an unannounced aesthetic movement that involves not only the theatre but all arts, this journal issue focuses on structuralist performance. The nine articles provide information on the following topics: the French theatre group, Atelier Theatre et Musique; "Tell Me," a play by Guy de Cointet; patterning in "Five…

  4. Research Article Special Issue

    African Journals Online (AJOL)

    2016-06-15

    Jun 15, 2016 ... Department of Psychology, Quchan Branch, Islamic Azad University, ... cluster sampling and a Motivational Strategies Learning (MSLQ) test, ... it, including issues that have always attracted the attention of trainers, teachers and experts of ... educational methods (Samadi, 2007), motivational beliefs (Kajbaf, ...

  5. Ethical issues in physiotherapy

    DEFF Research Database (Denmark)

    Præstegaard, Jeanette; Gard, Gunvor

    2012-01-01

    Background: An important aspect of physiotherapy professional autonomy is the ethical code of the profession, both collectively and for the individual member of the profession. The aim of this study is to explore and add additional insight into the nature and scope of ethical issues as they are u......Background: An important aspect of physiotherapy professional autonomy is the ethical code of the profession, both collectively and for the individual member of the profession. The aim of this study is to explore and add additional insight into the nature and scope of ethical issues......: The ideal of being beneficent toward the patient. Here, the ethical issues uncovered in the interviews were embedded in three code-groups: 1) ethical issues related to equality; 2) feeling obligated to do one's best; and 3) transgression of boundaries. Conclusions: In an ethical perspective, physiotherapy...... in private practice is on a trajectory toward increased professionalism. Physiotherapists in private practice have many reflections on ethics and these reflections are primarily based on individual common sense arguments and on deontological understandings. As physiotherapy by condition is characterized...

  6. Research Article Special Issue

    African Journals Online (AJOL)

    2016-05-15

    May 15, 2016 ... and accountable government and policy makers always a problem for any society is ... administrative reforms with the help of laws and regulations and the actions of other countries ... social, political, historical and economic issues and it is common in ... Employment system duck base on qualification. 3.

  7. Research Article Special Issue

    African Journals Online (AJOL)

    2016-05-15

    May 15, 2016 ... This research aims to study the issue of supply chain network ... company. In this paper, by considering effective factors of the chain we try to develop a comprehensive ...... mortar” retailing: The static case. European Journal of ...

  8. Maritime logistics: contemporary issues

    National Research Council Canada - National Science Library

    Song, D.W; Panayides, P.M

    2012-01-01

    ... in business and for study and research. This book is the first of its kind, adopting the innovative approach of dealing with the overlap between shipping, ports and logistics and covering the current issues having a significant impact on the industry...

  9. Ethical issues in biotechnology.

    Science.gov (United States)

    Polkinghorne, J C

    2000-01-01

    New ethical questions have arisen from our ability to intervene in the structure of the genome. Responsible use of this technique requires ethical evaluation in which experts, potential beneficiaries and the general public should all participate. The examples of genetically modified food and of human genetics help to illustrate the issues involved.

  10. The Fundamental Issues Study within the British BMD Review

    Science.gov (United States)

    1998-02-01

    towards ’Outer Space’: a realm identified in the evocative terminology of the 1987 Brundtland report as one of the three ’global commons’, the other...New Scientist, vol.149, no.2020, 9 March 1996, p.6. 14. Gro Harlem Brundtland , Chair, Our Common Future, Oxford University Press for World Commission

  11. International Association of Geomorphologists Newsletter

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The IAG has joined the European Federation of Geologists, European Geoparks Network, European Society for Soil Conservation, lUGS, and IGU to support the European Manifesto on Earth Heritage and Geodiversity. The active IAG Working Group on Geomorphological Sites also fosters he recognition and protection of sites of geomorphological significance. The European Manifesto, presented here, might serve as a model to be adapted for other countries or regions.

  12. Project Solo; Newsletter Number Seven.

    Science.gov (United States)

    Pittsburgh Univ., PA. Project Solo.

    The current curriculum modules under development at Project Solo are listed. The modules are grouped under the subject matter that they are designed to teach--algebra II, biology, calculus, chemistry, computer science, 12th grade math, physics, social science. Special programs written for use on the Hewlett-Packard Plotter are listed that may be…

  13. Advertising in This Issue

    Science.gov (United States)

    1999-12-01

    If you would like additional information about the products of the advertisers in this issue, the quickest and easiest way is via JCE Online's new service: Ad Index This will take you to the list of advertisers, each conveniently linked to their home page. To get advertising information via mail, fax, or email, refer to the top portion of the Readers Service Card inserted in the print issue. Whatever method of communication you use, be sure to mention to advertisers that you saw their ad in the Journal of Chemical Education. Advertising Representative McNeill Group, Inc. · 301 Oxford Valley Road, Suite 804 Yardley, PA 19067 · phone: 215/321-9662 or 800/275-5084 fax: 215/321-9636; email: jchemed@mcneill-group.com

  14. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu). On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu, cewqo08.phy.bg.ac.yu). On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and

  15. Colombia: Issues for Congress

    Science.gov (United States)

    2011-03-18

    studied at the University of Kansas and Harvard University , and the London School of Economics. Colombia: Issues for Congress Congressional Research...30, 2010, at http://www.lasillavacia.com/ historia /14953. 22 Camila Osorio, “Esta Es la Cara de la Legislatura que Se Posesiona Hoy,” La Silla Vacía...website, July 19, 2010, at http://www.lasillavacia.com/ historia /16740; “New Congress Grants Santos Huge Majority,” Latin American Weekly Report

  16. Issues of English Globalization

    Institute of Scientific and Technical Information of China (English)

    莫焕然

    2016-01-01

    In this essay, the complexity of the present situation of world Englishes, comments on the spread of the language, de-bate over standardized variants in English and the pedagogical implication relating to what types of English should be taught will be discussed. The expansion of English in China is then analyzed concerning issues such as attitudes towards local variety, desirable teaching models, and future adjustment.

  17. Issues in Target Tracking

    Science.gov (United States)

    2010-05-01

    the CUSUM (Page) test yields the quickest detection of a change of distribution for the case of i.i.d. observations [3]. In fact, in a (highly...11. Autocorrelation of the CUSUM increments, sn, under H1 (target present). Issues in Target Tracking RTO-EN-SET-157(2010...restrictive condition that the increments of the cumulative sum, sn, be i.i.d. [3], [22]. Fig. 11 plots the autocorrelation of the CUSUM increments as a

  18. Myanmar; Selected Issues

    OpenAIRE

    International Monetary Fund

    2015-01-01

    This Selected Issues paper analyzes how Myanmar can manage its natural resources for people’s development. Myanmar’s natural resource endowments provide much needed national wealth to finance the country’s development. Given Myanmar’s low tax revenue, mobilizing resource revenues is particularly important in the current macroeconomic environment of widening fiscal and current account deficits, inflationary pressures and exchange rate depreciation. The government should consider revisi...

  19. Symmetry issue in Galileons

    CERN Document Server

    Momeni, Davood

    2014-01-01

    The symmetry issue for Galileons has been studied. In particular we address scaling (conformal) and Noether symmetrized Galileons. We have been proven a series of theorems about the form of Noether conserved charge (current) for irregular (not quadratic) dynamical systems. Special attentions have been made on Galileons. We have been proven that for Galileons always is possible to find a way to "symmetrized" Galileo's field .

  20. Ukraine; Selected Issues

    OpenAIRE

    2008-01-01

    This Selected Issues paper investigates the economic importance of institutions in Ukraine, and attempts to quantify the potential benefits of market-friendly structural reforms. The paper reviews some of the key findings of the development-accounting literature, which has tried to explain the significant differences in income that persist across countries. It introduces the stochastic-frontier approach, outlining its key assumptions and strengths, and results obtained with the stochastic-fro...

  1. JPRS Report, Environmental Issues

    Science.gov (United States)

    1990-11-14

    Minister Issues ’Strong Warning’ on Gill Nets [Johannesburg Radio 18 Oct] 11 Health Minister on Plan for Protection of Ozone Layer [SAPA 18 Oct...government for Finnish beer, Scotch whisky , and Finnish meatballs. The hosts proudly displayed their state-of-the-art gadgets. Scientists who had...No one expects a breakthrough at the conference that would lead to swift actions to benefit the Baltic. Of the Baltic countries, Estonia and Latvia

  2. Ethical issues in publication.

    Science.gov (United States)

    Hamblet, J L

    1996-04-01

    Nurses usually publish to disseminate pertinent information and research findings. Their articles and textbooks promote quality patient care and sound professional practice. Nurses may also publish to meet requirements for academic promotion and professional advancement. Ethical issues play a part in any phase of writing for publication. Veracity, justice, beneficence, and nonmaleficence are four of the ethical principles that pertain to aspects of authorship, peer review, and research in publication.

  3. Wireless ATM : handover issues

    OpenAIRE

    Jiang, Fan; Käkölä, Timo

    1998-01-01

    Basic aspects of cellular systems and the ATM transmission technology are introduced. Wireless ATM is presented as a combination of radio ATM and mobile ATM. Radio ATM is a wireless extension of an ATM connection while mobile ATM contains the necessary extensions to ATM to support mobility. Because the current ATM technology does not support mobility, handover becomes one of the most important research issues for wireless ATM. Wireless ATM handover requirements are thus analysed. A handover s...

  4. Colombia: Issues for Congress

    Science.gov (United States)

    2008-09-12

    government has made in improving security conditions in Colombia, some Members of Congress have expressed concerns about labor activist killings and the para... Sistemas de Información de Población Desplazada,” July 31, 2006. 70 Department of State Bureau of Population, Refugees, and Migration, “Refugee Admissions...agreement are concerned about the status of labor rights in Colombia, as well as the ongoing para-political scandal. An issue of contention is the

  5. Accelerating News Issue 2

    CERN Document Server

    Kahle, K; Wildner, E

    2012-01-01

    In this summer issue we look at how developments in collimator materials could have applications in aerospace and beyond, and how Polish researchers are harnessing accelerators for medical and industrial uses. We see how the LHC luminosity upgrade is linking with European industry and US researchers, and how the neutrino oscillation community is progressing. We find out the mid-term status of TIARA-PP and how it is mapping European accelerator education resources.

  6. Introduction to Special Issue

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    This special issue presents the Italian approach to planned interventions by the Government and public institutions to counteract disability and handicap.Analysis of the provisions and laws which have followed on in time highlight the diversity between two types of approach:one that only considers physical or mental disability and one that also takes into consideration,besides these limitations,aspects linked to the social participation and integration of people with disabilities.

  7. JPRS Report, Proliferation Issues

    Science.gov (United States)

    2016-03-24

    TECHNICAL INFORMATION SERVICE SPRINGFIELD, VA 22161 PROLIFERATION ISSUES JPRS-TND-93-011 CONTENTS 23 April 1993 [This report contains foreign media ...likely after the U.N. Security [Text] Pyongyang, April 17 (KCNA)-Mass media of the Council adopts its first resolution against Pyongyang United States...his interview to the ARGUMENTY I FAKTY upon the path of confrontation and violence . We do not weekly President Leonid Kravchuk dismissed reports want

  8. ECMR’13 Special Issue

    OpenAIRE

    Andrade-Cetto, Juan; Frese, Udo; Moritz, Tenorth

    2015-01-01

    This special issue contains extended versions of the best papers from the 6th European Conference on Mobile Robots (ECMR). ECMR is a biennial European forum, internationally open, that allows roboticists throughout Europe to become acquainted with the latest research accomplishments and innovations in mobile robotics and mobile human–robot systems. ECMR covers most aspects of mobile robotics research and machine intelligence, including (but not limited to) the following topics: multi-sensor f...

  9. Euthanasia: the legal issues.

    Science.gov (United States)

    Chaloner, C; Sanders, K

    The legal status of euthanasia is frequently deliberated. It remains unlawful in Britain and advocates for a change in the law are vigorously opposed by those who argue that it should remain unchanged. An objective account, in which current law and arguments for and against change are exposed, is essential to inform the euthanasia debate. In this article the legal issues concerning euthanasia are examined and arguments raised by proposed changes in the law are considered.

  10. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-07-21

    requires export licenses for the following goods: "non- ferrous metals and ores, berlite, red tufa, Russia To Search Baltic granite, marble, brandy...responsibility for chemical weapons arose. On 19 Feb- became a trump card for the Ukrainian nationalists ruary 1992 the Russian president issued a decree to when...exported 84 tonnes of pipes made of Rhein-Bayern Fahrzeugbau, Kaufbeuren, igniters. an aluminum alloy to Iraq, enough to build 6,000 molec- ular pumps

  11. Due diligence issues report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-05-01

    The administrative and regulatory issues associated with offshore oil and gas exploration and development in British Columbia were discussed with reference to the creation of a management framework that would ensure that resource development occurs in a socially responsible manner. Provincial governments have jurisdiction over resource management, including intra-provincial trade, commerce and environmental issues within their borders. The federal government has control over resources, subsoil and the seabed out to 200 miles beyond the baseline. The federal government also regulates Frontier Lands, which are divided into Non-Accord and Accord areas. In Accord areas such as Newfoundland and Nova Scotia, oil and gas development is managed by the respective Offshore Petroleum Board. Currently, the British Columbia offshore is a Non-Accord area subject to the administration of Federal legislation. Environmental and regulatory issues were also discussed, along with regional equity, benefits planning, equity versus efficiency, proactivity, and public consultation. It was concluded that there is no scientific, technical or environmental barriers that would prevent the socially responsible development of British Columbia's offshore. There is also much evidence from other jurisdictions that indicates that British Columbia and Canada would benefit from prudent development of offshore oil and gas resources. refs., tabs., figs.

  12. Issues in waste combustion

    Energy Technology Data Exchange (ETDEWEB)

    Gustavsson, Lennart; Robertson, Kerstin; Tullin, Claes [Swedish National Testing and Research Inst., Boraas (Sweden); Sundquist, Lena; Wrangensten, Lars [AaF-Energikonsult AB, Stockholm (Sweden); Blom, Elisabet [AaF-Processdesign AB, Stockholm (Sweden)

    2003-05-01

    The main purpose of this review is to provide an overview of the state-of-the-art on research and development issues related to waste combustion with relevance for Swedish conditions. The review focuses on co-combustion in grate and fluidised bed furnaces. It is primarily literature searches in relevant databases of scientific publications with to material published after 1995. As a complement, findings published in different report series, have also been included. Since the area covered by this report is very wide, we do not claim to cover the issues included completely and it has not been possitile to evaluate the referred studies in depth. Basic knowledge about combustion issues is not included since such information can be found elsewhere in the literature. Rather, this review should be viewed as an overview of research and development in the waste-to-energy area and as such we hope that it will inspire scientists and others to further work in relevant areas.

  13. Editorial, Volume 5, Issue 1

    Directory of Open Access Journals (Sweden)

    Kristy L. Archuleta

    2014-08-01

    Full Text Available Welcome to Volume 5, Issue 1 of the Journal of Financial Therapy! In this issue, four scholarly papers are presented along with two profiles and a book review. These four papers address very important issues, such as mental health therapists’ competency in working with financial issues, financial stress of college students, parental messages about money, and financial advice media.

  14. School Meals Initiative (SMI). Nourishing News. Volume 4, Issue 4

    Science.gov (United States)

    Idaho State Department of Education, 2009

    2009-01-01

    The purpose of this newsletter is to help foodservice directors, supervisors, and managers successfully implement the U.S. Department of Agriculture's (USDA) School Meals Initiative (SMI) for Healthy Children regulations. Because there is so much available information on SMI, it can be overwhelming to find answers to your questions and concerns.…

  15. Issue 6, Editorial

    Directory of Open Access Journals (Sweden)

    Judith Winters

    1999-07-01

    Full Text Available There has been more interest than I'd ever anticipated in issue 6 "Digital Publication", the first themed issue of Internet Archaeology - so much so that several more related articles have been submitted and will appear in issue 7! The discussion on linearity and hypertext, arising from the contributions by Cornelius Holtorf and Andre Costopoulos, also generated some serious and lengthy debate on our email discussion list intarch-interest for the first time too, and my thanks go out to all who participated - active authorship and readership in practice. Archaeologists are using the web and other electronic media more than ever now, but I believe that this is not just "because it's there". Theoretically and practically, the internet is a valuable tool for us. On the web, rather than on the printed page, we can come closer to fulfilling our concerns about dissemination, we can more easily incorporate many "voices" and facilitate the opening up of our work and our interpretations to critical inquiry, immediately and on a global scale. At the same time, the web also offers new and experimental ways of expressing and communicating our work, and the flexibility of the medium means that our information can even be layered in complexity - depth and the building up of layers and meaning are concepts that every archaeologist is familiar with after all! But there's one more reason why I think archaeology and the web should be embraced. The printed word lies at the very core of a discipline like history; archaeology, on the other hand, is made up of what we see (images, what we feel (experience, what we find (material, what we read (text - it is multimedia. So what better way to communicate all these things than in a like-minded medium?

  16. Ethical issues in nanotechnology.

    Science.gov (United States)

    Florczyk, Stephen J; Saha, Subrata

    2007-01-01

    Nanotechnology is a rapidly developing area in science involved with manipulating matter at the atomic or molecular level. Nanotechnology is typically defined at a scale on the order of less than approximately 100 nm. Matter possesses unique properties at these size levels that are neither Newtonian nor quantum, but between the two regimes.These unique properties have created significant interest and excitement, sparking numerous research investigations. Nanotechnology is a very broad field with many current and potential applications. Some important examples of applications include battlefield activated dynamic armor clothing for soldiers, additives to sunscreens, and diagnostic laboratories on a chip to monitor general personal health. Groundbreaking capabilities often raise new questions. Any new scientific or technological development has the usual concomitant associated ethical issues, specifically regarding containment and regulation. These ethical issues are more pronounced with nanotechnology due to the sharp divide between those who see its great potential and opponents who express fears. Nanotechnology supporters believe that it has the potential to transform our lives dramatically, while opponents of nanotechnology fear that self-replicating "nanobots" could escape from laboratories and reduce all life on earth to "gray goo. "These fears have swayed generally uninformed public opinions via the media and sensational entertainment. A critical discussion of ethical issues surrounding nanotechnology, including the interaction of nanotechnology with the body and the environment--nanobiotechnology--and regulation of nanotechnology, is presented. We advocate strong, uniform regulations for nanotechnology, but only the use of regulations as needed. The limited use of regulations prevents the regulations from becoming burdensome and inhibiting research in the field.

  17. Organizational issues = change.

    Science.gov (United States)

    Lorenzi, Nancy M; Riley, Robert T

    2003-03-01

    Information systems fail for a number of reasons. Several failure reasons include communication, complexity, organization, technology, and leadership. Failure can be outlined in four major categories: technical shortcomings, project management shortcomings, organizational issues, and the continuing information explosion. Change management is the process of assisting individuals and organizations in passing from an old way of doing things to a new way of doing things. Change management starts early in a technical process, as the need for making major changes starts at the conceptual level. This paper briefly covers the people side of implementing new information systems, and describes resistance to change and various strategies to manage technological change.

  18. Accelerating News Issue 4

    CERN Document Server

    Szeberenyi, A; Wildner, E

    2012-01-01

    In this winter issue, we are very pleased to announce the approval of EuCARD-2 by the European Commission. We look at the conclusions of EUROnu in proposing future neutrino facilities at CERN, a new milestone reached by CLIC and progress on the SPARC upgrade using C-band technology. We also report on recent events: second Joint HiLumi LHC-LARP Annual Meeting and workshop on Superconducting technologies for the Next Generation of Accelerators aiming at closer collaboration with industry. The launch of the Accelerators for Society brochure is also highlighted.

  19. Ethical issues in transgenics.

    Science.gov (United States)

    Sherlock, R; Morrey, J D

    2000-01-01

    The arguments of critics and concerns of the public on generating transgenic cloned animals are analyzed for the absence or presence of logical structure. Critics' arguments are symbolically compared with "genetic trespassing," "genetic speeding," or "going the wrong way," and responses are provided to these arguments. Scientists will be empowered to participate in the public discussion and to engage the critics on these issues as they consider thoughtful, plausible responses to their concerns. Temporary moratoriums are recognized as a plausible approach to dealing with possible concerns of new scientific advancements.

  20. JPRS Report: Proliferation Issues

    Science.gov (United States)

    2016-03-24

    Industry (MITI) plans to hold a seminar on arms export control as early as this fall in an Asian country. The countries include Indonesia, Malaysia ...NPT BK1703072393 Kuala Lumpur BERNAMA in English 0604 GMT 17 Mar 93 [Text] Kuala Lumpur, March 17 (OANA/ BERNAMA)— Malaysia Wednesday, expressed ...JPRS-TND-93-009 29 March 1993 !■■■■! FOREIGN BROADCAST INFORMATION SERVICE JPRS Report— Proliferation Issues Sapsevsd tea ßubSa t©l©ɛ

  1. Orbital debris issues

    Science.gov (United States)

    Kessler, D. J.

    Orbital debris issues fall into three major topics: Environment Definition, Spacecraft Hazard, and Space Object Management. The major issue under Environment Definition is defining the debris flux for sizes smaller (10 cm in diameter) than those tracked by the North American Aerospace Defense Command (NORAD). Sources for this size debris are fragmentation of larger objects, either by explosion or collision, and solid rocket motor products. Modeling of these sources can predict fluxes in low Earth orbit which are greater than the meteoroid environment. Techniques to measure the environment in the size interval between 1 mm and 10 cm are being developed, including the use of telescopes and radar both on the ground and in space. Some impact sensors designed to detect meteoroids may have detected solid rocket motor products. Once the environment is defined, it can be combined with hypervelocity impact data and damage criteria to evaluate the Spacecraft Hazard. Shielding may be required to obtain an acceptable damage level. Space Object Management includes techniques to control the environment and the desired policy to effectively minimize the hazard to spacecraft. One control technique - reducing the likelihood of future explosions in space - has already been implemented by NASA. The effectiveness of other techniques has yet to be evaluated.

  2. CLOUD COMPUTING SECURITY ISSUES

    Directory of Open Access Journals (Sweden)

    Florin OGIGAU-NEAMTIU

    2012-01-01

    Full Text Available The term “cloud computing” has been in the spotlights of IT specialists the last years because of its potential to transform this industry. The promised benefits have determined companies to invest great sums of money in researching and developing this domain and great steps have been made towards implementing this technology. Managers have traditionally viewed IT as difficult and expensive and the promise of cloud computing leads many to think that IT will now be easy and cheap. The reality is that cloud computing has simplified some technical aspects of building computer systems, but the myriad challenges facing IT environment still remain. Organizations which consider adopting cloud based services must also understand the many major problems of information policy, including issues of privacy, security, reliability, access, and regulation. The goal of this article is to identify the main security issues and to draw the attention of both decision makers and users to the potential risks of moving data into “the cloud”.

  3. Global Energy Issues

    Energy Technology Data Exchange (ETDEWEB)

    Suto, M.

    2007-07-01

    The e8 is a Non-Government Organization of nine power companies from the G8 countries. It was established in 1992 to play an active role in global electricity issues and to promote sustainable energy development. The e8 is governed by the Chairmen of the member companies, who exchange their views on common themes of the year at their annual Summit meetings. At the Evian Summit in May 2006, the Chairmen discussed 'Global Energy Issues' and established a common statement of e8 commitments and recommendations as follows: (1) Optimum mix of energy supply, (2) Investment for infrastructure and demand growth, (3) Promoting sustainable energy development by sharing expertise, (4) Cooperation among electricity companies, (5) Integration and modernisation of transmission networks, (6) Inclusion of large scale-technologies under the Flexible Mechanisms, (7) International financial institutions, (8) Developments of long-term contracts in the electricity sector, (9) International Institutions - Producer and Consumer Countries, (10) Public acceptance. Guided by this statement, e8 will stride ahead toward achieving 3A's (Accessibility, Availability, Acceptability) globally. (auth)

  4. Bituminous sands : tax issues

    Energy Technology Data Exchange (ETDEWEB)

    Patel, B. [PricewaterhouseCoopers LLP, Calgary, AB (Canada)

    2004-07-01

    This paper examined some of the tax issues associated with the production of bitumen or synthetic crude oil from oil sands. The oil sands deposits in Alberta are gaining more attention as the supplies of conventional oil in Canada decline. The oil sands reserves located in the Athabasca, Cold Lake and Peace River areas contain about 2.5 trillion barrels of highly viscous hydrocarbons called bitumen, of which nearly 315 billion barrels are recoverable with current technology. The extraction method varies for each geographic area, and even within zones and reservoirs. The two most common extraction methods are surface mining and in-situ extraction such as cyclic steam stimulation (CSS); low pressure steam flood; pressure cycle steam drive; steam assisted gravity drainage (SAGD); hot water flooding; and, fire flood. This paper also discussed the following general tax issues: bituminous sands definition; bituminous sands leases and Canadian development expense versus Canadian oil and gas property expense (COGPE); Canadian exploration expense (CEE) for surface mining versus in-situ methods; additional capital cost allowance; and, scientific research and experimental development (SR and ED). 15 refs.

  5. Clinical research: regulatory issues.

    Science.gov (United States)

    Wermeling, D P

    1999-02-01

    The regulatory issues faced by institutions performing clinical research are described. Many institutions do not have on staff an expert who understands the regulatory issues involved in managing investigational new drug research and who knows the institution's obligations under the federal rules. Because pharmacists understand the FDA regulations that apply to the management of drugs in clinical research, institutions are asking pharmacists to expand their role and manage clinical research offices. Many authorities govern various aspects of investigational drug research. FDA has published regulations for good clinical practice (GCP), and the International Conference on Harmonisation is developing an international standard for the proper management of clinical trials. The guidelines published by the Joint Commission on Accreditation of Healthcare Organizations aim to protect patients who are in the institution to receive health care and also participate in clinical trials. The Social Security Administration Acts specifically state that only items and services that are reasonable and necessary for the diagnosis and treatment of injury or disease can be billed to the government; research-related billings are excluded from coverage. Proper management of drug research is crucial to the success of a research program that is integrated with patient care.

  6. Environmental issues in China

    Energy Technology Data Exchange (ETDEWEB)

    Travis, P.S.

    1991-10-01

    Global concern about the environment is increasing, and the People's Republic of China (PRC) is not immune from such concerns. The Chinese face issues similar to those of many other developing nations. The US Department of Energy is particularly interested in national and world pollution issues, especially those that may infringe on other countries' economic growth and development. The DOE is also interested in any opportunities that might exist for US technical assistance and equipment in combating environmental problems. Our studies of articles in the China Daily, and English-language daily newspaper published by the Chinese government, show that population, pollution, and energy are major concerns of the Chinese Communist Party. Thus this report emphasizes the official Chinese government view. Supporting data were also obtained from other sources. Regardless of the severity of their various environmental problems, the Chinese will only try to remedy those problems with the greatest negative effects on its developing economy. They will be looking for foreign assistance, financial and informational, to help implement solutions. With the Chinese government seeking assistance, the United States has an opportunity to export basic technical information, especially in the areas of pollution control and monitoring, oil exploration methods, oil drilling technology, water and sewage treatment procedures, hazardous waste and nuclear waste handling techniques, and nuclear power plant safety procedures. In those areas the US has expertise and extensive technical experience, and by exporting the technologies the US would benefit both economically and politically. 59 refs., 3 figs.

  7. Drug Abuse on College Campuses: Emerging Issues. Issues in Prevention

    Science.gov (United States)

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2012

    2012-01-01

    This "Issues in Prevention" focuses on emerging issues concerning drug abuse on college campuses. This issue contains the following articles: (1) Drug Abuse Trends; (2) Q&A With Jim Lange; (3) Bath Salts; (4) Refuse to Abuse; (5) Related Federal Resource; and (6) Higher Education Center Resources.

  8. DEGRO 2006: 12. annual congress of the German Radiation Oncology Society, 10. annual meeting of SASRO and 22. annual meeting of OeGRO. Abstracts; DEGRO 2006 - 12. Jahreskongress der Deutschen Gesellschaft fuer Radioonkologie, 10. Jahrestagung der SASRO und 22. Jahrestagung der OeGRO. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-05-15

    The volume displays the abstracts of the meetings of the German, Swiss, and Austrian societies for radiooncology. Issues of the lectures, posters, and symposia were: new technological developments, head-neck tumors, radiobiology, prostate carcinomas, radiotherapy in palliative treatment, hematological malignomas, tumors of gastrointestinal tract, bladder, brain, breast, or bronchi, carrier planning, women in the field of radiooncology, image-guided radiotherapy, sexuality, fertility and pregnancy with gynecological tumors, psychooncology, pediatric oncology and radiotherapy, sex-dependent radiosensitivity, dosimetry, irradiation planning, quality of life in radiooncology, radiooncological information systems. (uke)

  9. Ergonomics Issues in Malaysia

    Directory of Open Access Journals (Sweden)

    H. S. Loo

    2012-01-01

    Full Text Available Problem statement: Ergonomics so far has had little impact in Malaysia. For most Malaysian managers, ergonomics is not considered to be associated with performance, but rather with occupational health and safety and legislation. Approach: This study reviews the development of ergonomics in Malaysia and the underlying issues related to national development. Results: Many changes need to be made within the ergonomics research, education and practice community by integrating concepts from the social sciences with technological advances into Malaysian culture to enhance productivity and sustainable improvements in the quality of life, while achieving essential health and safety goals. Conclusion/Recommendation: Ergonomics helps to improve performance besides enhancing workplace OSH. It is essential to promote ergonomics concepts and practice to various industries in Malaysia. More effort and skills are required to compensate for the lack of infrastructure in providing a framework within which ergonomics recommendations can be disseminated and realized.

  10. Space radiation protection issues.

    Science.gov (United States)

    Kronenberg, Amy; Cucinotta, Francis A

    2012-11-01

    The complex charged particle environments in space pose considerable challenges with regard to potential health consequences that can impact mission design and crew selection. The lack of knowledge of the biological effects of different ions in isolation and in combination is a particular concern because the risk uncertainties are very high for both cancer and non-cancer late effects. Reducing the uncertainties is of high priority. Two principal components of space radiation each raise different concerns. Solar particle events (SPE) occur sporadically and are comprised primarily of low- to moderate-energy protons. Galactic cosmic radiation (GCR) is isotropic and relatively invariant in dose rate. GCR is also dominated by protons, but the energy range is wider than in SPE. In addition, the contribution of other light and heavy ions to the health risks from GCR must be addressed. This paper will introduce the principal issues under consideration for space radiation protection.

  11. Methylmercury risk assessment issues

    Energy Technology Data Exchange (ETDEWEB)

    Lipfert, F.W. [Brookhaven National Lab., Upton, NY (United States); Saroff, L. [USDOE, Washington, DC (United States)

    1996-07-01

    This paper reviews the general background of health risks associated with mercury (Hg), primarily methylmercury (MeHg), with a view towards application to advanced technologies that could reduce any contributions from coal combustion. The need for accurate assessment of such risks is discussed, since Hg is now widely dispersed in the environment and cannot easily be eliminated. The primary pathway of MeHg intake is through eating contaminated fish. The issues of concern include identification of critical health outcomes (various neurological indices) and their confounding factors, accurate assessment of MeHg intake rates, and appropriate use of dose-response functions. Ultimately, such information will be used to evaluate alternative coal combustion systems.

  12. Software Tool Issues

    Science.gov (United States)

    Hennell, Michael

    This chapter relies on experience with tool development gained over the last thirty years. It shows that there are a large number of techniques that contribute to any successful project, and that formality is always the key: a modern software test tool is based on a firm mathematical foundation. After a brief introduction, Section 2 recalls and extends the terminology of Chapter 1. Section 3 discusses the the design of different sorts of static and dynamic analysis tools. Nine important issues to be taken into consideration when evaluating such tools are presented in Section 4. Section 5 investigates the interplay between testing and proof. In Section 6, we call for developers to take their own medicine and verify their tools. Finally, we conclude in Section 7 with a summary of our main messages, emphasising the important role of testing.

  13. Issues in energy finance

    Science.gov (United States)

    Khokher, Zeigham Islam

    As opposed to the well developed and understood equity markets, the energy markets are still in their infancy. The explosion of contracts, of both the primary and derivative types, are testament both to the existing size and the untapped growth potential of this exciting industry. However, because of its relative youth many basic issues in the energy markets remain unresolved. This thesis introduces some interesting questions and provides insights into these issues. Thematically, the chapters of this thesis are linked by an emphasis on valuation and risk management decisions. A contribution of this thesis is to show that subtle differences between the endogenous price process in our general equilibrium setting and the exogenous processes considered in earlier papers can generate significant differences in both financial and real option values. In addition to these valuation concerns there has been much debate about the corporate risk management function. Finance theory suggests that a value maximizing corporation should either be indifferent to hedging or, in the presence of certain imperfections, it should completely hedge all exposures. Both these extremes contradict empirical evidence. We show that existing corporate hedging behaviour is best explained in light of both physical market imperfections and directional predictions on future prices. While these speculative motives may arise from corporate hubris or genuine informational advantages, we argue that it would be difficult to implement private information in the absence of noise traders. Related to the risk management decision is the existence of futures risk premia. These premia have been thought to be cause by covariance with priced factors or due to the hedging demands of consumers and producers. This thesis argues that inventories serve as a signal of available quantity, which coupled with consumers fears regarding stockouts can induce a positive relationship between premia and inventories. In

  14. Integrating Mathematics and Social Issues

    Science.gov (United States)

    Harrell, Gregory K.

    2007-01-01

    This article illustrates how to integrate mathematics with social issues. Social issues discussed in the newspaper provide a rich context for connecting mathematical activities to the real world. The sample activities focus on measurement concepts. (Contains 2 figures.)

  15. Medical and Dental Patient Issues

    Science.gov (United States)

    ... A RadiationAnswers.org Ask the Experts Medical and Dental Patient Issues What's My Risk? The risks of ... developed by our topic editors for this category: Dental-Patient Issues Medical CT Reference Books and Articles ...

  16. Mental Health Issues & Down Syndrome

    Science.gov (United States)

    ... Mental Health Issues & Down Syndrome Mental Health Issues & Down Syndrome What Are the Major Mental Health Related Concerns in Persons With Down Syndrome? At least half of all children and adults ...

  17. Launch Services Program EMC Issues

    Science.gov (United States)

    trout, Dawn

    2004-01-01

    Presentation covers these issues: (1) Vehicles of the Launch Services Program, (2) RF Environment, (3) Common EMC Launch Vehicle Payload Integration Issues, (4) RF Sensitive Missions and (5) Lightning Monitoring,

  18. Neoprene splinting: dermatological issues.

    Science.gov (United States)

    Stern, E B; Callinan, N; Hank, M; Lewis, E J; Schousboe, J T; Ytterberg, S R

    1998-01-01

    Occupational therapists are expanding their use of custom and commercial soft splints fabricated from neoprene (polychloroprene), but little has been written regarding dermatological issues associated with this material. Skin contact with neoprene poses two dermatological risks: allergic contact dermatitis (ACD) and miliaria rubra (i.e., prickly heat). Allergic reaction to neoprene is generally ascribed to the accelerants used to manufacture the man-made rubber, specifically thiourea compounds and mercaptobenzothiazole (MBT). Symptoms of neoprene-related ACD include itching, skin eruptions, swelling, and hemorrhages into the skin. Miliaria rubra creates small, red, elevated, inflammatory papules and a tingling, burning sensation. Although neoprene hypersensitivity is rare, its incidence may grow as neoprene becomes a more commonly used material. It is recommended that therapists screen patients for a history of dermatological reactions to neoprene or other materials containing thiourea compounds or MBT and educate patients to discontinue splint use if dermatological symptoms develop. Therapists are also encouraged to notify splint manufacturers regarding all ACD reactions.

  19. Social Issues in Proposals

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    During the annual session of the 11th National Committee of the Chinese People’s Political Consultative Conference (CPPCC) that concluded on March 14,1,992 of the total 2,236 members at the beginning of their five-year term in China’s top advisory body submitted 4,772 proposals. Members of the CPPCC National Committee put forward proposals to offer comments and suggestions on major po- litical and social issues of the country.A proposal can be raised by one member or a group of members;by one or more groups jointly;in the name of a party or non-government group that has joined the CPPCC;or in the name of a sub- committee of the CPPCC National Committee. Out of the proposals that were classified during the conference,1,863 or 41.16 percent were on economic matters;1,405 or 31.04 percent were on education,scientific research,entertainment,health care and sports;and 1,258 proposals or 27.8 percent were on legal affairs and social seeurity. During the pnst five years,the CPPCC National Committee handled over 23,000 proposals,of which 21,843 were sent to government branches in charge of the matters for solution. Following are summaries of some selected proposals.

  20. Pregnancy issues in scleroderma.

    Science.gov (United States)

    Lidar, Merav; Langevitz, Pnina

    2012-05-01

    Systemic sclerosis is a systemic, inflammatory, autoimmune disease affecting the skin and viscera, manifesting pathologically with microvascular lesions, perivascular infiltration by mononuclear cells and increased deposition of extracellular collagen. The rarity of the disease as well as its propensity to appear in the early 1940s, explain the low frequency of concurrent scleroderma and pregnancy. However, the marked female excess, as well as the trend for increasing maternal age due to social change and assisted reproductive technologies, renders heightened significance to issues of fertility, pregnancy course and pregnancy outcomes. In the past, scleroderma patients were thought to be at high risk for poor fetal and maternal outcome, but more current retrospective studies show that despite an increased frequency of prematurity and small for gestational age infants, overall maternal and neonatal survival is good. Hence, at present, with close monitoring and appropriate therapy most scleroderma patients can sustain a successful pregnancy. Therapy with hydroxychloroquine and low dose steroids as well as judicious use of intravenous immunoglobulins is permitted. Renal crisis remains the most dreaded complication of a scleroderma pregnancy and necessitates prompt institution of ACE inhibitor therapy despite its potential teratogenicity. In order minimize the risk for renal crisis, pregnancies should be avoided in rapidly progressive diffuse disease as such patients are at a greater risk for developing serious cardiopulmonary and renal problems early in the disease. This review shall focus on the bi-directional effects of scleroderma on fertility and pregnancy as well as on the management of pregnancy and delivery in the scleroderma patient.

  1. Special Issue: Tsallis Entropy

    Directory of Open Access Journals (Sweden)

    Anastasios Anastasiadis

    2012-02-01

    Full Text Available One of the crucial properties of the Boltzmann-Gibbs entropy in the context of classical thermodynamics is extensivity, namely proportionality with the number of elements of the system. The Boltzmann-Gibbs entropy satisfies this prescription if the subsystems are statistically (quasi- independent, or typically if the correlations within the system are essentially local. In such cases the energy of the system is typically extensive and the entropy is additive. In general, however, the situation is not of this type and correlations may be far from negligible at all scales. Tsallis in 1988 introduced an entropic expression characterized by an index q which leads to a non-extensive statistics. Tsallis entropy, Sq, is the basis of the so called non-extensive statistical mechanics, which generalizes the Boltzmann-Gibbs theory. Tsallis statistics have found applications in a wide range of phenomena in diverse disciplines such as physics, chemistry, biology, medicine, economics, geophysics, etc. The focus of this special issue of Entropy was to solicit contributions that apply Tsallis entropy in various scientific fields. [...

  2. Issues of environmental (irresponsibility

    Directory of Open Access Journals (Sweden)

    Jana Dundelová

    2013-01-01

    Full Text Available In this paper the author reflects the questions of humans’ relationship to the environment and of their ecological behaviour that becomes together with the development of modern technologies increasingly relevant just as the question whether humans are able to affect fundamentally the environment on the Earth by their activities. According to some authors (e.g. Ehrlich, 1968; Gore, 2006; Wilson, 1995; Winter, Koger, 2009; Šmajs, 2005 human survival is directly connected with people’s relationship to the nature; but other influential authors have contradictory opinions or they are at least afraid of overestimation of ecological activities that can lead to neglecting of other important problems (e.g. Simon, 1981; Goklany, 2007; Lomborg, 2007; Klaus, 2007, 2009.These issues are dealt in this article mainly from the perspective of psychological theories and concepts – the Freud’s concept of unconsciousness is discussed as well as groupthink, theory of dissonance, contingency trap, Milgram’s theory of autonomous and agentic state of consciousness, group and intergroup behaviour, social dilemma – tragedy of the commons. Achieving a sustainable way of life depends on the equilibrium between consumption of individuals and regenerative abilities of the natural environment. However, people still behave as if they were separated from the nature. The linking axis of this article is the question of psychic powers causing individual and collective ecological (irresponsibility and the resulting consequences.

  3. Nanofluids research: key issues.

    Science.gov (United States)

    Wang, Liqiu; Fan, Jing

    2010-05-22

    Nanofluids are a new class of fluids engineered by dispersing nanometer-size structures (particles, fibers, tubes, droplets) in base fluids. The very essence of nanofluids research and development is to enhance fluid macroscopic and megascale properties such as thermal conductivity through manipulating microscopic physics (structures, properties and activities). Therefore, the success of nanofluid technology depends very much on how well we can address issues like effective means of microscale manipulation, interplays among physics at different scales and optimization of microscale physics for the optimal megascale properties. In this work, we take heat-conduction nanofluids as examples to review methodologies available to effectively tackle these key but difficult problems and identify the future research needs as well. The reviewed techniques include nanofluids synthesis through liquid-phase chemical reactions in continuous-flow microfluidic microreactors, scaling-up by the volume averaging and constructal design with the constructal theory. The identified areas of future research contain microfluidic nanofluids, thermal waves and constructal nanofluids.

  4. In This Issue

    Science.gov (United States)

    1996-07-01

    Composing the Curriculum For your summer reading pleasure this month's issue provides a wide range of subjects and activities. Our lead article is a tribute to a chemist-composer, Lejaren A. Hiller, Jr., as well as an examination of the interesting relationship between chemistry (and science) and music. Like Hiller, Wamser and Wamser (page 601) love both chemistry and music, and this comes through loud and clear in their historical perspective on Hiller's work. Much of the rest of the issue impinges on the chemistry curriculum in one form or another. Rettich, Bailey, Frank, and Frick (page 638) describe an integrated first- and second-year curriculum being developed at Illinois Wesleyan University that includes all subdisciplines of chemistry. They describe ways to teach topics such as acids and bases so that the perspectives of (for example) organic and inorganic chemistry are integrated and contemporaneous. Those contemplating a popular reform, group work or cooperative learning, will be interested in Birk and Kurtz's program (page 615) for training teaching assistants using cooperative learning. Surely TAs who have participated in cooperative groups to develop their own techniques for handling discussion and lab sessions will be able to use group learning to better advantage. Several years ago the ACS Division of Chemical Education set up a Task Force on the General Chemistry Curriculum. With support from the National Science Foundation and others, the task force has been quite active. In addition to the summative reports published here (pages 617-636) on four areas in which general chemistry teaching can be improved, they have contributed many Forum columns in earlier issues of the Journal and have published much of their work in New Directions for General Chemistry: A Resource for Curricular Change; Baird W. Lloyd, ed. Our current approach to teaching electron configurations of the atoms is largely based on quantum theory Because of the mathematics required

  5. Acknowledgment - Issue 60

    Directory of Open Access Journals (Sweden)

    Executive Editor

    2015-11-01

    Full Text Available Biblios wish to acknowledge the support of the following professionals who participated in the review process of submissions for our issue 60.ReviewersAndré Ancona Lopez (Universidade de Brasília - UnB, BrasilGildenir Carolino Santos (Universidade Estadual de Campinas - UNICAMP, BrasilJacira Gil Bernardes (Universidade Federal do Rio Grande do Sul - UFRGS, BrasilRodrigo Donoso Vegas (Universidad de Chile - UCHILE, ChileSaúl Hiram Souto Fuentes (Universidad de Monterrey - UDEM, MéxicoReviewers invitedAlejandro Uribe Tirado (Universidad de Antioquia - UDEA, ColombiaFernanda Passini Moreno (Universidade de Brasília - UnB, BrasilJosé Bernal Rivas Fernández (Universidad de Costa Rica - UCR, Costa RicaMarta Lígia Pomim Valentim (Universidade Estadual Paulista - UNESP, BrasilOrlando Corzo Cauracurí (Universidad Nacional Mayor de San Marcos - UNMSM, PerúTerezinha Elisabeth da Silva (Universidade Estadual de Londrina - UEL, BrasilZaira Regina Zafalon (Universidade Federal de São Carlos - UFSCAR, BrasilIn the same way our acknowledge to University Library System (University of Pittsburgh - PITTS, USA by constant technical support and advice for our journal.

  6. Nanofluids Research: Key Issues

    Directory of Open Access Journals (Sweden)

    Wang Liqiu

    2010-01-01

    Full Text Available Abstract Nanofluids are a new class of fluids engineered by dispersing nanometer-size structures (particles, fibers, tubes, droplets in base fluids. The very essence of nanofluids research and development is to enhance fluid macroscopic and megascale properties such as thermal conductivity through manipulating microscopic physics (structures, properties and activities. Therefore, the success of nanofluid technology depends very much on how well we can address issues like effective means of microscale manipulation, interplays among physics at different scales and optimization of microscale physics for the optimal megascale properties. In this work, we take heat-conduction nanofluids as examples to review methodologies available to effectively tackle these key but difficult problems and identify the future research needs as well. The reviewed techniques include nanofluids synthesis through liquid-phase chemical reactions in continuous-flow microfluidic microreactors, scaling-up by the volume averaging and constructal design with the constructal theory. The identified areas of future research contain microfluidic nanofluids, thermal waves and constructal nanofluids.

  7. Formation Flying Concept Issues

    Directory of Open Access Journals (Sweden)

    M. V. Palkin

    2015-01-01

    Full Text Available The term “formation flying” implies coordinated movement of at least two satellites on coplanar and non-coplanar orbits with a maximum distance between them being much less than the length of the orbit. Peculiarities of formation flying concept also include:- automatic coordination of satellites;- sub-group specialization of formation flying satellites;- equipment and data exchange technology unification in each specialized group or subgroup.Formation flying satellites can be classified according to the configuration stability level (order (array, cluster («swarm», intergroup specialization rules («central satellite», «leader», «slave», manoeuvrability («active» and «passive» satellites.Tasks of formation flying include:- experiments with payload, distributed in formation flying satellites;- various near-earth space and earth-surface research;- super-sized aperture antenna development;- land-based telescope calibration;- «space advertisement» (earth-surface observable satellite compositions of a logotype, word, etc.;- orbital satellite maintenance, etc.Main issues of formation flying satellite system design are:- development of an autonomous satellite group manoeuvring technology;- providing a sufficient characteristic velocity of formation flying satellites;- ballistic and navigation maintenance for satellite formation flying;- technical and economic assessment of formation flying orbital delivery and deployment;- standardization, unification, miniaturization and integration of equipment;- intergroup and intersatellite function redistribution.

  8. Radioactive waste storage issues

    Energy Technology Data Exchange (ETDEWEB)

    Kunz, Daniel E. [Colorado Christian Univ., Lakewood, CO (United States)

    1994-08-15

    In the United States we generate greater than 500 million tons of toxic waste per year which pose a threat to human health and the environment. Some of the most toxic of these wastes are those that are radioactively contaminated. This thesis explores the need for permanent disposal facilities to isolate radioactive waste materials that are being stored temporarily, and therefore potentially unsafely, at generating facilities. Because of current controversies involving the interstate transfer of toxic waste, more states are restricting the flow of wastes into - their borders with the resultant outcome of requiring the management (storage and disposal) of wastes generated solely within a state`s boundary to remain there. The purpose of this project is to study nuclear waste storage issues and public perceptions of this important matter. Temporary storage at generating facilities is a cause for safety concerns and underscores, the need for the opening of permanent disposal sites. Political controversies and public concern are forcing states to look within their own borders to find solutions to this difficult problem. Permanent disposal or retrievable storage for radioactive waste may become a necessity in the near future in Colorado. Suitable areas that could support - a nuclear storage/disposal site need to be explored to make certain the health, safety and environment of our citizens now, and that of future generations, will be protected.

  9. Acetobacter sicerae sp. nov., isolated from cider and kefir, and identification of species of the genus Acetobacter by dnaK, groEL and rpoB sequence analysis.

    Science.gov (United States)

    Li, Leilei; Wieme, Anneleen; Spitaels, Freek; Balzarini, Tom; Nunes, Olga C; Manaia, Célia M; Van Landschoot, Anita; De Vuyst, Luc; Cleenwerck, Ilse; Vandamme, Peter

    2014-07-01

    Five acetic acid bacteria isolates, awK9_3, awK9_4 ( = LMG 27543), awK9_5 ( = LMG 28092), awK9_6 and awK9_9, obtained during a study of micro-organisms present in traditionally produced kefir, were grouped on the basis of their MALDI-TOF MS profile with LMG 1530 and LMG 1531(T), two strains currently classified as members of the genus Acetobacter. Phylogenetic analysis based on nearly complete 16S rRNA gene sequences as well as on concatenated partial sequences of the housekeeping genes dnaK, groEL and rpoB indicated that these isolates were representatives of a single novel species together with LMG 1530 and LMG 1531(T) in the genus Acetobacter, with Acetobacter aceti, Acetobacter nitrogenifigens, Acetobacter oeni and Acetobacter estunensis as nearest phylogenetic neighbours. Pairwise similarity of 16S rRNA gene sequences between LMG 1531(T) and the type strains of the above-mentioned species were 99.7%, 99.1%, 98.4% and 98.2%, respectively. DNA-DNA hybridizations confirmed that status, while amplified fragment length polymorphism (AFLP) and random amplified polymorphic DNA (RAPD) data indicated that LMG 1531(T), LMG 1530, LMG 27543 and LMG 28092 represent at least two different strains of the novel species. The major fatty acid of LMG 1531(T) and LMG 27543 was C18 : 1ω7c. The major ubiquinone present was Q-9 and the DNA G+C contents of LMG 1531(T) and LMG 27543 were 58.3 and 56.7 mol%, respectively. The strains were able to grow on D-fructose and D-sorbitol as a single carbon source. They were also able to grow on yeast extract with 30% D-glucose and on standard medium with pH 3.6 or containing 1% NaCl. They had a weak ability to produce acid from d-arabinose. These features enabled their differentiation from their nearest phylogenetic neighbours. The name Acetobacter sicerae sp. nov. is proposed with LMG 1531(T) ( = NCIMB 8941(T)) as the type strain. © 2014 IUMS.

  10. Issue Management Risk Ranking Systems

    Energy Technology Data Exchange (ETDEWEB)

    Novack, Steven David; Marshall, Frances Mc Clellan; Stromberg, Howard Merion; Grant, Gary Michael

    1999-06-01

    Thousands of safety issues have been collected on-line at the Idaho National Engineering and Environmental Laboratory (INEEL) as part of the Issue Management Plan. However, there has been no established approach to prioritize collected and future issues. The authors developed a methodology, based on hazards assessment, to identify and risk rank over 5000 safety issues collected at INEEL. This approach required that it was easily applied and understandable for site adaptation and commensurate with the Integrated Safety Plan. High-risk issues were investigated and mitigative/preventive measures were suggested and ranked based on a cost-benefit scheme to provide risk-informed safety measures. This methodology was consistent with other integrated safety management goals and tasks providing a site-wide risk informed decision tool to reduce hazardous conditions and focus resources on high-risk safety issues. As part of the issue management plan, this methodology was incorporated at the issue collection level and training was provided to management to better familiarize decision-makers with concepts of safety and risk. This prioritization methodology and issue dissemination procedure will be discussed. Results of issue prioritization and training efforts will be summarized. Difficulties and advantages of the process will be reported. Development and incorporation of this process into INEELs lessons learned reporting and the site-wide integrated safety management program will be shown with an emphasis on establishing self reliance and ownership of safety issues.

  11. Issue Management Risk Ranking Systems

    Energy Technology Data Exchange (ETDEWEB)

    F. M. Marshall; G. M. Grant; H. M. Stromberg; S. D. Novack

    1999-06-01

    Thousands of safety issues have been collected on-line at the Idaho National Engineering and Environmental Laboratory (INEEL) as part of the Issue Management Plan. However, there has been no established approach to prioritize collected and future issues. The authors developed a methodology, based on hazards assessment, to identify and risk rank over 5000 safety issues collected at INEEL. This approach required that it was easily applied and understandable for site adaptation and commensurate with the Integrated Safety Plan. High-risk issues were investigated and mitigative/preventive measures were suggested and ranked based on a cost-benefit scheme to provide risk-informed safety measures. This methodology was consistent with other integrated safety management goals and tasks providing a site-wide risk-informed decision tool to reduce hazardous conditions and focus resources on high-risk safety issues. As part of the issue management plan, this methodology was incorporated at the issue collection level and training was provided to management to better familiarize decision-makers with concepts of safety and risk. This prioritization methodology and issue dissemination procedure will be discussed. Results of issue prioritization and training efforts will be summarized. Difficulties and advantages of the process will be reported. Development and incorporation of this process into INEEL's lessons learned reporting and the site-wide integrated safety management program will be shown with an emphasis on establishing self reliance and ownership of safety issues.

  12. Newsletter, National Center for the Study of Collective Bargaining in Higher Education and the Professions, Vol. 8, No. 4, November 1980.

    Science.gov (United States)

    Levenstein, Aaron, Ed.

    1980-01-01

    Developments in the area of academic collective bargaining are examined. Issues pertaining to interest and final offer arbitration are discussed, with attention to authority of judicial arbitrators and interest arbitrators, standards for the interest arbitrator, and public sector problems. Information on strikes in the fall of 1980 indicate no…

  13. Mars Surface Environmental Issues

    Science.gov (United States)

    Charles, John

    2002-01-01

    Planetary exploration by astronauts will require extended periods of habitation on a planet's surface, under the influence of environmental factors that are different from those of Earth and the spacecraft that delivered the crew to the planet. Human exploration of Mars, a possible near-term planetary objective, can be considered a challenging scenario. Mission scenarios currently under consideration call for surface habitation periods of from 1 to 18 months on even the earliest expeditions. Methods: Environmental issues associated with Mars exploration have been investigated by NASA and the National Space Biomedical Research Institute (NSBRI) as part of the Bioastronautics Critical Path Roadmap Project (see http ://criticalpath.jsc.nasa.gov). Results: Arrival on Mars will immediately expose the crew to gravity only 38% of that at Earth's surface in possibly the first prolonged exposure to gravity other than the 1G of Earth's surface and the zero G of weightless space flight, with yet unknown effects on crew physiology. The radiation at Mars' surface is not well documented, although the planet's bulk and even its thin atmosphere may moderate the influx of galactic cosmic radiation and energetic protons from solar flares. Secondary radiation from activated components of the soil must also be considered. Ultrafine and larger respirable and nonrespirable particles in Martian dust introduced into the habitat after surface excursions may induce pulmonary inflammation exacerbated by the additive reactive and oxidizing nature of the dust. Stringent decontamination cannot eliminate mechanical and corrosive effects of the dust on pressure suits and exposed machinery. The biohazard potential of putative indigenous Martian microorganisms may be assessed by comparison with analog environments on Earth. Even in their absence, human microorganisms, if not properly controlled, can be a threat to the crew's health. Conclusions: Mars' surface offers a substantial challenge to the

  14. Geo Issue Tracking System

    Science.gov (United States)

    Khakpour, Mohammad; Paulik, Christoph; Hahn, Sebastian

    2016-04-01

    Communication about remote sensing data quality between data providers and users as well as between the users is often difficult. The users have a hard time figuring out if a product has known problems over their region of interest and data providers have to spend a lot of effort to make this information available, if it exists. Scientific publications are one tool for communicating with the users base but they are static and mostly one way. As a data provider it is also often difficult to make feedback, received from users, available to the complete user base. The Geo Issue Tracking System (GeoITS) is an Open Source Web Application which has been developed to mitigate these problems. GeoITS combines a mapping interface (Google Maps) with a simple wiki platform. It allows users to give region specific feedback on a remote sensing product by drawing a polygon on the map and describing the problems they had using the remote sensing product in this area. These geolocated wiki entries are then viewable by other users as well as the data providers which can modify and extend the entries. In this way the conversations between the users and the data provider are no longer hidden in e.g. emails but open for all users of the dataset. This new kind of communication platform can enable better cooperation between users and data providers. It will also provide data providers with the ability to track problems their dataset might have in certain areas and resolve them with new product releases. The source code is available via http://github.com/TUW-GEO/geoits_dev A running instance can be tried at https://geoits.herokuapp.com/

  15. In This Issue

    Science.gov (United States)

    1996-04-01

    Advanced Instrumentation in the Educational Laboratory The instruments that chemists use in their research have changed dramatically in the past decades. The explosion in new techniques and their instrumental counterparts has been made possible by two significant advances. The rapid propagation of computer chips and circuitry provides opportunities to collect more specialized and refined data than ever before. Computer-controlled instruments can detect events that a human researcher would never perceive and can record hundreds of data points in the time that a person could only observe one or two. Coupled with these advances in technology are advances in theory that allow more sophisticated interpretation of data. A hundred years ago a sophisticated instrument was a balance that could weigh minute quantities. Today a sophisticated instrument is one that can identify the composition of that minute sample, determine its molecular weight, or reveal a great deal about its energy states and bonding. This bonanza of new instruments is wonderful for the research chemist but a curricular headache for the chemistry teacher. It takes more time to learn how to run an NMR than to use a balance, and more sophistication on the part of the student is needed to interpret the data. And yet many courses that only a generation ago sported an expensive analytical balance as its prize instrument now require students to understand and operate a whole panoply of complex tools. Teachers faced with accommodating these curricular changes will find several articles in this issue helpful--either providing information on new techniques or descriptions of how to incorporate them into the classroom. Electrospray ionization mass spectrometry is one of the newest tools that has been added to the analytical arsenal. It is an extension of mass spectrometry that overcomes the old barrier that allowed only analysis of low molecular weight, volatile compounds. It is now possible to use MS for

  16. Ethical issues in neuroprosthetics

    Science.gov (United States)

    Glannon, Walter

    2016-04-01

    Objective. Neuroprosthetics are artificial devices or systems designed to generate, restore or modulate a range of neurally mediated functions. These include sensorimotor, visual, auditory, cognitive affective and volitional functions that have been impaired or lost from congenital anomalies, traumatic brain injury, infection, amputation or neurodevelopmental and neurodegenerative disorders. Cochlear implants, visual prosthetics, deep brain stimulation, brain-computer interfaces, brain-to-brain interfaces and hippocampal prosthetics can bypass, replace or compensate for dysfunctional neural circuits, brain injury and limb loss. They can enable people with these conditions to gain or regain varying degrees of control of thought and behavior. These direct and indirect interventions in the brain raise general ethical questions about weighing the potential benefit of altering neural circuits against the potential harm from neurophysiological and psychological sequelae. Other ethical questions are more specific to the therapeutic goals of particular neuroprosthetics and the conditions for which they are indicated. These include informed consent, agency, autonomy (free will) and identity. Approach. This review is an analysis and discussion of these questions. It also includes consideration of social justice issues such as how to establish and implement fair selection criteria in providing access to neuroprosthetic research and balancing technological innovation with patients’ best interests. Main results. Neuroprosthetics can restore or improve motor and mental functions in bypassing areas of injury or modulating dysregulation in neural circuits. As enabling devices that integrate with these circuits, neuroprosthetics can restore varying degrees of autonomous agency for people affected by neurological and psychiatric disorders. They can also re-establish the connectedness and continuity of the psychological properties they had before injury or disease onset and thereby

  17. The hydrogen issue.

    Science.gov (United States)

    Armaroli, Nicola; Balzani, Vincenzo

    2011-01-17

    Hydrogen is often proposed as the fuel of the future, but the transformation from the present fossil fuel economy to a hydrogen economy will need the solution of numerous complex scientific and technological issues, which will require several decades to be accomplished. Hydrogen is not an alternative fuel, but an energy carrier that has to be produced by using energy, starting from hydrogen-rich compounds. Production from gasoline or natural gas does not offer any advantage over the direct use of such fuels. Production from coal by gasification techniques with capture and sequestration of CO₂ could be an interim solution. Water splitting by artificial photosynthesis, photobiological methods based on algae, and high temperatures obtained by nuclear or concentrated solar power plants are promising approaches, but still far from practical applications. In the next decades, the development of the hydrogen economy will most likely rely on water electrolysis by using enormous amounts of electric power, which in its turn has to be generated. Producing electricity by burning fossil fuels, of course, cannot be a rational solution. Hydroelectric power can give but a very modest contribution. Therefore, it will be necessary to generate large amounts of electric power by nuclear energy of by renewable energies. A hydrogen economy based on nuclear electricity would imply the construction of thousands of fission reactors, thereby magnifying all the problems related to the use of nuclear energy (e.g., safe disposal of radioactive waste, nuclear proliferation, plant decommissioning, uranium shortage). In principle, wind, photovoltaic, and concentrated solar power have the potential to produce enormous amounts of electric power, but, except for wind, such technologies are too underdeveloped and expensive to tackle such a big task in a short period of time. A full development of a hydrogen economy needs also improvement in hydrogen storage, transportation and distribution

  18. Mega-constellations Issues

    Science.gov (United States)

    Bastida Virgili, Benjamin; Krag, Holger

    2016-07-01

    increase drastically. In this study, we report the detected issues of such a mega-constellation traffic, and we analyse the response of the space object population to the introduction of a large constellation conforming to the post-mission disposal guideline with differing levels of success and with different disposal orbit options.

  19. In This Issue

    Science.gov (United States)

    1996-06-01

    Organic Chemistry--New Challenges Perhaps more than any other of the chemical subdisciplines, the scope and focus of organic chemistry has been changed by modern technology and theoretical advances, and these changes have had an equally striking effect on the undergraduate curriculum. The main challenge in organic chemistry classes has shifted, in less than a generation, from memorizing all the groups, naming conventions, and classes of reactions to understanding complex interactions at the structural and electronic orbital level. As biochemistry and polymer chemistry have grown from being the purview of a few specialists to full-blown disciplines of their own, they have also migrated from interesting, but optional, chapters at the back of the book to separate courses in the curriculum. The availability of inexpensive instrumentation means undergraduates routinely use NMR and mass spec instead of melting points to identify their products. And the changes are continuing: segments of biochemistry are metamorphizing into molecular biology and polymer chemistry is finding interconnections with materials science. In fact, as our understanding of chemical reactions at molecular and electronic levels expands, it becomes more and more difficult to decide on demarcations between the subdisciplines. Organic chemistry is an organizational construct that once was useful for segregating certain topics into a coherent two-semester introductory course. Today, it covers so much territory that no one who is an "organic chemist" can know even a small fraction of the territory and faces unique challenges when designing and teaching undergraduate courses. In a wide spectrum of articles in this issue that fall under the "organic" umbrella--from environmental chemistry to new polymer products--teachers share their specific experiences and creative solutions to these challenges, providing their colleagues with new ideas, processes, and pedagogic approaches. To start off, we can examine

  20. Current issues with research support

    Energy Technology Data Exchange (ETDEWEB)

    Russell, W.T.

    1996-03-01

    It would be difficult to condense current issues in nuclear reactor regulation to just a few minutes. So, let me start off by saying that I have not tried to give a comprehensive listing of issues that are currently facing the reactor program, but rather to select those that I thought were relevant as they relate to research activities. Use of probabilistic risk assessment in regulatory decisions; materials aging issues concerning steam generators and reactor vessels; high burnup fuels; accident management; and digital instrumentation and control, are just a sampling of the important issues that I want to talk about.

  1. Policy issues in modern cartography

    CERN Document Server

    Taylor, DRF

    1998-01-01

    Policy Issues in Modern Cartography contains the views of national mapping agencies, legal scholars, the library community, the private sector and academia on these and many other important issues. The book begins with perspectives from national mapping agencies in Britain, Canada and the United States followed by a survey of the situation in Asia. The next three chapters deal primarily with legal issues such as copyright and intellectual property from both North American and European perspectives. Chapter 8 presents an important perspective on the key issues by a representative of the privat

  2. In This Issue

    Science.gov (United States)

    1996-02-01

    Computational Chemistry for the Masses Not long ago, chemical computation was considered a specialty area requiring extensive computer knowledge, power, and time. Over the past decade, however, it has changed from the arcane pursuit of a few advanced university researchers in the area of physical chemistry to a familiar tool used by a wide range of chemists. Nevertheless, it has required its practitioners to have extensive knowledge of computer programming and a thorough understanding of theoretical chemical concepts and as a result usually was reserved for the graduate curriculum. Now a further metamorphosis is in progress, as computational chemistry moves into the undergraduate curriculum, often using off-the-shelf software--commercial packages or adaptations of them that are readily shared by their creators. As we put this issue together, we realized that many of the articles involved sophisticated computations that would not have been possible a few years ago in the courses described. Further, the hard and software used was widely available at a reasonable cost. Some of the articles focus on the teaching of computational methods and others simply incorporate it as a facet in their overall strategy; however, taken together, they reflect a strong trend to utilize a diverse set of readily available methods and products in the undergraduate curriculum. The most familiar recent use of computational chemistry is the computer design of molecules in organic, medicinal, and biochemistry. However, computational chemistry is useful for inorganic chemists as well and is now migrating to undergraduate courses. Lipkowitz, Pearl, Robertson, and Schultz (page 105) make a strong case for its inclusion and present a two-week component they have developed for their senior-level laboratory course. Comba and Zimmer (page 108) offer a review of inorganic molecular mechanics calculations, which is designed for the novice and includes the basic equations, their application to

  3. Current Issues in Cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Barbour, J B [Department of Physics and Astronomy, University of Rochester (United States)

    2007-02-07

    These colloquium proceedings will be valuable, the blurb says, for graduate students and researchers in cosmology and theoretical astrophysics. Specifically, the book 'looks at both the strengths and weaknesses of the current big bang model in explaining certain puzzling data' and gives a 'comprehensive coverage of the expanding field of cosmology'. The reality is rather different. Conference proceedings rarely compare in value with a solid monograph or good review articles, and Current Issues in Cosmology is no exception. The colloquium was convened by the two editors, who have both long harboured doubts about the big bang, and was held in Paris in June 2004. The proceedings contain 19 presented papers and relatively brief summary comments by four panel speakers. The questions and answers at the end of each talk and a general discussion at the end were recorded and transcribed but contain little of interest. The nature of the colloquium is indicated by panellist Francesco Bertola's comment: 'While in the 1950s it was possible to speak of rival theories in cosmology, now the big-bang picture has no strong rivals. This is confirmed by the fact that out of 1500 members of the IAU Division VIII (Galaxies and the Universe) only a dozen, although bright people, devote their time to the heterodox views.' This was largely a platform for them to give their views. At least half of the dozen, all the 'usual suspects', were present: Geoffery and Margaret Burbidge, Jayant Narlikar, Halton Arp, Chandra Wickramasinghe and, in spirit only but playing a role somewhat like the ghost of Hamlet's father, the late Fred Hoyle. Doubters presented 12 of the 19 papers. Orthodoxy should certainly be challenged and the sociology of science questioned, but I found two main problems with this book. The papers putting the orthodox view are too short, even perfunctory. The most that a serious graduate student would get out of them is a reference

  4. The NCSS Public Issues Program.

    Science.gov (United States)

    McFarland, Mary

    1989-01-01

    Describes programs sponsored by the National Council for the Social Studies (NCSS) to promote civic participation. The programs are National Issues Forums (NIF) in the Classroom; Jefferson Meetings; Great Decisions; Public Issues Series; and C-SPAN in the Classroom. (SLM)

  5. Issue ownership and party choice

    NARCIS (Netherlands)

    Brug, van der Wouter

    2004-01-01

    This study presents an empirical test of the extent to which the “issue ownership” model explains the electoral decisions of individual voters. The model has been tested mainly by its ability to predict aggregate election results by issue salience (e.g., Budge and Farlie, 1983 and Petrocik, 1996). A

  6. Teaching Gender Issues through Literature.

    Science.gov (United States)

    McClish, Glen

    The issues of empiricism and theory-building can be used in practical terms to discuss how literary texts can be used to elucidate gender issues in the classroom. For instance, two literary texts written early in this century--Thornton Wilder's "Our Town" and Ernest Hemingway's short story "Up in Michigan"--can illustrate…

  7. Editorial Volume 5 Issue 3

    Directory of Open Access Journals (Sweden)

    Ciorstan J. Smark

    2011-09-01

    Full Text Available This issue of AABFJ contains a diverse range of articles from accounting, finance, financial planning and education. This issue leads with an article by Cowen, Blair and Taylor (2011 who examine, using a detailed case study, the educational technique of scaffolding to enhance the teaching and learning experiences of both staff and students in the teaching of financial planning.

  8. Issues in Training Family Scientists.

    Science.gov (United States)

    Ganong, Lawrence H.; And Others

    1995-01-01

    Issues related to graduate education in family science, especially at the doctoral level, are explored. Discusses competencies family scientists should have, as well as experiences necessary to help students acquire them. Proposes ideas for a core curriculum, identifies controversies and unresolved issues, and examines training for the future.…

  9. Issues in Training Family Scientists.

    Science.gov (United States)

    Ganong, Lawrence H.; And Others

    1995-01-01

    Issues related to graduate education in family science, especially at the doctoral level, are explored. Discusses competencies family scientists should have, as well as experiences necessary to help students acquire them. Proposes ideas for a core curriculum, identifies controversies and unresolved issues, and examines training for the future.…

  10. Introduction to the Special Issue

    OpenAIRE

    Benati, Alessandro; Lee, James F.

    2015-01-01

    [Without Abstract]\\ud Introduction to International Review of Applied Linguistics in Language Teaching, Volume 53, Issue 2 (Jun 2015)- Special Issue: Processing instruction: New insights after twenty years of theory, research and application. Guest Editors: Alessandro Benati and James F. Lee.

  11. Simulation of Effect of Irrigation with Reclaimed Water on Soil Water-Salt Movement by ENVIRO-GRO Model%模型模拟再生水灌溉对土壤水盐运动的影响

    Institute of Scientific and Technical Information of China (English)

    吕斯丹; 陈卫平; 王美娥

    2012-01-01

    As the conflict between water supply and demand,wastewater reuse has become an important measure,which can relieve the water shortage in Beijing.In order to promote safe irrigation with reclaimed water and prevent soil salinisation,the dynamic transport of salts in urban soils of Beijing,a city of water shortage,under irrigation of reclaimed water was simulated by ENVIRO-GRO model in this research.The accumulation trends of soil salinity were predicted.Simultaneously,it investigated the effects of different irrigation practices on soil water-salt movement and salt accumulation.Results indicated that annual averages of soil salinity(ECe) increased 29.5%,97.2%,197.8% respectively,with the higher irrigation,normal irrigation,and low irrigation under equilibrium conditions.Irrigation frequency had little effect on soil salt-water movement,and soil salt accumulation was in a downward trend with low frequency of irrigation.Under equilibrium conditions,annual averages of ECe increased 23.7%,97.2%,208.5% respectively,with irrigation water salinity(ECw) 0.6,1.2,2.4 dS·m-1.Soil salinity increased slightly with ECw=0.6 dS·m-1,while soil salinization did not appear.Totally,the growth of Blue grass was not influenced by soil salinity under equilibrium conditions with the regular irrigation in Beijing,but mild soil salinization appeared.%随着水资源供需矛盾日益尖锐,污水再生利用成为了缓解北京水资源紧缺的重要举措.为推动北京再生水安全灌溉,本研究运用ENVIRO-GRO模型模拟缺水城市北京再生水灌溉土壤水盐运动规律,并对土壤盐分累积进行预测,探讨了不同灌溉措施对土壤水盐运动规律和盐分累积的影响.结果表明,高水量、常规、低水量灌溉,平衡时土壤含盐量(ECe)年均值分别增加了29.5%、97.2%、197.8%;灌溉频率对土壤水盐运动规律影响不大,但低频灌溉下土壤中盐分的累积有减少的趋势;灌溉水含盐量(ECw)为0.6、1.2、2.4 d

  12. C-FERST Environmental Issue Profiles

    Science.gov (United States)

    This page provides links to the 45 issue profiles for C-FERST users, organized with tabs to show issues related to pollutants, environmental media, health effects, other community issues, and all issues.

  13. Tribal-FERST Environmental Issue Profiles

    Science.gov (United States)

    This page provides links to the 45 issue profiles for Tribal-FERST users, organized with tabs to show issues related to pollutants, environmental media, health effects, other community issues, and all issues.

  14. Recent Water Issues in China

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The rapid urbanization process in China over the past thirty years has significantly improved the living standards of Chinese people. But it also poses severe environmental pressure on environment including water. This paper discusses the water issues like urban water supply, water pollution and water quality of water system in the context of the rapid urbanization process in China. It then proposes strategic measures to tackle those water issues and discusses the progress of providing safe drinking water and protecting water resources by new technologies in-cluding membrane technology. It concludes that water is a global issue and should be tackled by global community together.

  15. Issue Professionals in Transnational Networks

    DEFF Research Database (Denmark)

    Henriksen, Lasse Folke; Seabrooke, Leonard

    Relations to discuss how professionals and organizations battle over issue control through the designation of tasks and the creation of overlapping networks. We outline the emergence of ‘issue professionals’ and how they attempt network management. We do so via a case on transnational sustainability......Professionals and organizations both seek to exploit and cooperate with each other. Professionals seek alliances in their own peer networks while organizations do the same. These networks carry not only information that inform incentives but norms about appropriate forms of governance and practices...... that guide how they actually work. In this paper we outline how professionals and organizations operate in two-level networks through a focus on issue control over issues of transnational governance. As such, this interdisciplinary paper brings together insights from Organization Studies and International...

  16. Health Issues of Premature Babies

    Science.gov (United States)

    ... Text Size Email Print Share Health Issues of Premature Babies Page Content Because premature babies are born before they are physically ready ... associated with prematurity. Because of these health concerns, premature babies are given extra medical attention and assistance ...

  17. Professional Issues In Software Engineering

    CERN Document Server

    Bott, Frank; Eaton, Jack; Rowland, Diane

    2000-01-01

    An comprehensive text covering all the issues that software engineers now have to take into account apart from the technical side of things. Includes information on the legal, professional and commercial context in which they work.

  18. The Origin of the Issue

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Yang : Hello, everybody ! Recently, the discussion on constructing the security cooperative mechanism of Northeast Asia has been increasing both at home and abroad, which has almost t become another hot topic next to the Korean nuclear issue. Why is there such a phenomenon? Judging from the perspective of the regional situation, there have appeared two respects of "changing" and "unchanging" factors in the past few years. Should we consider that the "unchanging factors"have led to the breakout of the Korean Peninsula nuclear crisis again,and the "changing factors" have caused new changes in the regional circumstance following the crisis and the ways of resolving the issue; and with the Korean nuclear issue as a turning point, have these "changing" and "unchanging" factors led to warming-up of the issue of the regional security mechanism in both positive and negative ways?

  19. Editorial Volume 5 Issue 4

    Directory of Open Access Journals (Sweden)

    Ciorstan Smark

    2011-12-01

    Full Text Available Welcome to the final issue of AABFJ for 2012.1. The journal has grown in the past year with an increase in submissions and the editors are considering strategies to manage future publications.

  20. Special Issue on Graph Algorithms

    OpenAIRE

    2013-01-01

    This special issue of Algorithms is devoted to the design and analysis of algorithms for solving combinatorial problems of a theoretical or practical nature involving graphs, with a focus on computational complexity.

  1. Professional Emergence on Transnational Issues

    DEFF Research Database (Denmark)

    Seabrooke, Leonard; Tsingou, Eleni

    2015-01-01

    they are conceptually linked by actors and organizations. A linked ecologies approach asks us to displace locating known actors within structures and instead pays attention to professional interactions on how ‘issue distinctions’ are made, the relationship between issue distinctions and professional tasks, and who......Addressing complex transnational problems requires coordination from different professionals. The emergence of new actors and issues has been addressed by those interested in studies of organizations through concepts and methods that highlight the importance of communities, fields, and networks....... These approaches are important in identifying the sources of what becomes established, but less geared to identifying interactions that are emergent. This article extends a linked ecologies approach to emergence, arguing that interaction on transnational issues should first be understood by how...

  2. Editorial Volume 9, Issue 2

    Directory of Open Access Journals (Sweden)

    Monir Mir

    2015-06-01

    Full Text Available There are five excellent studies which are published in this issue of Australasian Accounting, Banking and Finance Journal (AABFJ. As summarised below, out of these five studies, four of the studies have investigated and explored various accounting, finance and accountability issues of emerging and developing economies. Although more needs to be done, it is encouraging to observe that researchers from developing and emerging economies have been making progress in disseminating their research findings to the interested global communities.

  3. Business Ethics: Some Theoretical Issues

    OpenAIRE

    Lluka, Valon

    2010-01-01

    Ethics can be defined as a process of evaluating actions according to moral principal of values. Throughout the centuries people were trying to choose between profit and moral. Perhaps, some of them obtain both, but every time it could have roused ethical issues. Those issues concern fairness, justice, rightness or wrongness; as a result it can only be resolved according to ethical standards. Setting the ethical standards for the way of doing business in corporation is primarily task of m...

  4. Call for Special Issue Proposals

    OpenAIRE

    2014-01-01

    The Interdisciplinary Journal of Problem-Based Learning is seeking proposals for guest edited special topics issue to be published in 2016. The special issue should focus on a targeted area of interest relevant to problem-based learning, project-based learning, case-based learning, anchored instruction, or inquiry broadly. We are open to any areas of specialized interest, whether they are context, content, or process related.

  5. Gender issues of financial analysts

    OpenAIRE

    Jingwen Ge

    2013-01-01

    Increased attention has been drawn to the gender disparity in workplace. This dissertation is dedicated to provide sight to the gender issues in financial analysts. Profound literature reviews are conducted about gender issues and financial analysts, respectively in order to comprehend the existing gender concerns in the business world, and role and functions of financial analysts. Research proposals are described to answer the following question: whether women financial analysts are more lik...

  6. Some methodological issues in biosurveillance.

    Science.gov (United States)

    Fricker, Ronald D

    2011-02-28

    This paper briefly summarizes a short course I gave at the 12th Biennial Centers for Disease Control and Prevention (CDC) and Agency for Toxic Substances and Disease Registry (ATSDR) Symposium held in Decatur, Georgia on April 6, 2009. The goal of this short course was to discuss various methodological issues of biosurveillance detection algorithms, with a focus on the issues related to developing, evaluating, and implementing such algorithms.

  7. Perspectiva de género para el análisis de la participación femenina en organizaciones ambientalistas. El caso de la organización de mujeres ecologistas de la Sierra de Petatlán, Gro

    Directory of Open Access Journals (Sweden)

    Josu00E9 Maru00EDa Aranda Su00E1nchez

    2007-01-01

    Full Text Available Con base en el análisis empírico de la Organización de Mujeres Ecologistas de la Sierra de Petatlán, Gro., este artículo propone un esquema de análisis de la participación de mujeres en organizaciones no gubernamentales ambientalistas, desde una perspectiva de género, haciendo énfasis en el estudio de las relaciones más significativas, no siempre visibles, que las mujeres establecen como activistas realizando determinadas acciones colectivas a favor del ambiente y la ecología. Esas relaciones se expresan como: a Trabajo extradoméstico; b Situación social de las mujeres; c Relaciones de las mujeres con la naturaleza, y d Relaciones de las mujeres con las instituciones.

  8. Demystifying green buildings through green building issues, case studies and resources

    Energy Technology Data Exchange (ETDEWEB)

    Simon, L.N.

    1996-05-01

    Information and research on sustainability, energy and environmental efficiency, and {open_quotes}green{close_quotes} technologies and products is emerging at a rapid rate. Worldwide, organizations are developing green databases, resource guides, standards, specifications, videos, assessment methods, and research tools to educate the building industry, non-profit organizations, governmental agencies, and the general public. Learning what information is available, knowing where to locate the resources, and accessing this information is the first step in designing and building green buildings. The American Society for Testing Materials (ASTM) describes green buildings as residential, industrial and commercial structures that are designed, constructed, renovated, operated, and reused in an environmentally and energy-efficient manner. Specifically, green buildings aim to lessen their global impact through energy and resource efficiency, to provide good indoor environmental and air quality, to assure occupant health and productivity, to encourage efficient modes of transportation, and to improve the site where they are located. These concepts need to be addressed not as a single issue, however, but in an integrated approach. Green designers and builders recognize that a decision made in one area often affects decisions made in others. Ideally, green building concepts are applied throughout the {open_quotes}whole building{close_quotes}, and over its entire life cycle. Below is a list of green building resources organized by the life cycle of a green building, beginning with their Significance, and including Site Design, Building Design, Construction Process, Building Management and Operations & Maintenance. The resources include books, newsletters, sourcebooks, government publications, and electronic tools.

  9. Ethical & Legal Issues in School Counseling. Chapter 6: Special Issues.

    Science.gov (United States)

    Sampson, James P., Jr.; And Others

    This document contains chapter 6 (5 articles) of a collection of 35 articles primarily from American Association for Counseling and Development (AACD) publications on the most important legal and ethical topics about which all school counselors need to be informed. "Ethical Issues Involved With the Use of Computer-Assisted Counseling, Testing, and…

  10. Legal issues in radon affairs

    Energy Technology Data Exchange (ETDEWEB)

    Massuelle, M.H. [Inst. de Protection et de Surete Nucleaire, Fontenay aux Roses (France)

    1999-12-01

    In France, it was only recently that cases related to high radon concentrations in dwellings received substantial publicity. This irruption of radon as a public health issue came with the general progress of scientific knowledge and the availability of a research capacity in France able to develop expertise. We are interested here in the legal implications of issues that arise from the lag between the activity of expertsand the regulatory activity in the domain of radon. We use the term expertise very broadly, to cover the practical application of research findings, the relation of the researchers with the community, and finally the acts by which experts provide their knowledge to the community. We first examine the course by which science developed the radon issue and the way they organized to move from research to expertise; here we try to characterize the various needs for radon expertise. We then discuss the legal difficulties associated with radon expertise.

  11. Introduction to the special issue

    Directory of Open Access Journals (Sweden)

    Gorka Elordieta

    2007-06-01

    Full Text Available For the past few years there has been an intense and increasing collaboration effort between researchers working on the Iberian languages, and this is particularly true in the realm of phonetics and phonology. The 'Journal of Portuguese Linguistics 'has played a role in contributing to stimulate such a collaborative research focusing on the Iberian languages: first with a Special Issue on 'Variation and Change in the Iberian Languages: the Peninsula and Beyond', and now with a Special Issue on the 'Prosody of Ibero-Romance and Related Languages'. In fact, to broaden its scope of coverage to the Iberian languages has become an explicit goal of the journal. As guest-editors of this issue, we are very pleased to be able to contribute to this objective, which we find an extremely fruitful one.

  12. Special Issue: "Molecules against Alzheimer".

    Science.gov (United States)

    Decker, Michael; Muñoz-Torrero, Diego

    2016-12-16

    This Special Issue, entitled "Molecules against Alzheimer", gathers a number of original articles, short communications, and review articles on recent research efforts toward the development of novel drug candidates, diagnostic agents and therapeutic approaches for Alzheimer's disease (AD), the most prevalent neurodegenerative disorder and a leading cause of death worldwide. This Special Issue contains many interesting examples describing the design, synthesis, and pharmacological profiling of novel compounds that hit one or several key biological targets, such as cholinesterases, β-amyloid formation or aggregation, monoamine oxidase B, oxidative stress, biometal dyshomeostasis, mitochondrial dysfunction, serotonin and/or melatonin systems, the Wnt/β-catenin pathway, sigma receptors, nicotinamide phosphoribosyltransferase, or nuclear erythroid 2-related factor. The development of novel AD diagnostic agents based on tau protein imaging and the use of lithium or intranasal insulin for the prevention or the symptomatic treatment of AD is also covered in some articles of the Special Issue.

  13. Ruby on Rails Issue Tracker

    Science.gov (United States)

    Rodriguez, Juan Jared

    2014-01-01

    The purpose of this report is to detail the tasks accomplished as a NASA NIFS intern for the summer 2014 session. This internship opportunity is to develop an issue tracker Ruby on Rails web application to improve the communication of developmental anomalies between the Support Software Computer Software Configuration Item (CSCI) teams, System Build and Information Architecture. As many may know software development is an arduous, time consuming, collaborative effort. It involves nearly as much work designing, planning, collaborating, discussing, and resolving issues as effort expended in actual development. This internship opportunity was put in place to help alleviate the amount of time spent discussing issues such as bugs, missing tests, new requirements, and usability concerns that arise during development and throughout the life cycle of software applications once in production.

  14. Legal issues in radon affairs

    Energy Technology Data Exchange (ETDEWEB)

    Massuelle, M.H. [Inst. de Protection et de Surete Nucleaire, Fontenay aux Roses (France)

    1999-12-01

    In France, it was only recently that cases related to high radon concentrations in dwellings received substantial publicity. This irruption of radon as a public health issue came with the general progress of scientific knowledge and the availability of a research capacity in France able to develop expertise. We are interested here in the legal implications of issues that arise from the lag between the activity of expertsand the regulatory activity in the domain of radon. We use the term expertise very broadly, to cover the practical application of research findings, the relation of the researchers with the community, and finally the acts by which experts provide their knowledge to the community. We first examine the course by which science developed the radon issue and the way they organized to move from research to expertise; here we try to characterize the various needs for radon expertise. We then discuss the legal difficulties associated with radon expertise.

  15. Ethical issues in livestock cloning.

    Science.gov (United States)

    Thompson, P B

    1999-01-01

    Although cloning may eventually become an important technology for livestock production, four ethical issues must be addressed before the practice becomes widespread. First, researchers must establish that the procedure is not detrimental to the health or well-being of affected animals. Second, animal research institutions should evaluate the net social benefits to livestock producers by weighing the benefits to producers against the opportunity cost of research capacity lost to biomedical projects. Third, scientists should consider the indirect effects of cloning research on the larger ethical issues surrounding human cloning. Finally, the market structure for products of cloned animals should protect individual choice, and should recognize that many individuals find the prospect of cloning (or consuming cloned animals) repugnant. Analysis of these four issues is complicated by spurious arguments alleging that cloning will have a negative impact on environment and genetic diversity.

  16. Census 2001: issues and perspectives.

    Science.gov (United States)

    1998-01-01

    This article discusses the Census of India for 2001 and gender issues such as the sex ratio, undercounts of girls, tribe and scheduled caste data, and the data users' conference. The April 1998 conference was attended by representatives of government planning and development departments, research institutions, and statisticians and researchers. Under consideration was a government Ministry of Welfare proposal to reintroduce, after a 60-year hiatus, data by scheduled caste and tribe. This issue is complicated by criteria that vary by state and includability. Quotas for backward classes in educational institutions, government jobs, and in decision-making bodies are the reason for designations by caste. Some groups are distressed because of lack of inclusion as backward classes. M.N. Srinivas strongly advises that counting by caste will create problems for enumerators and will result in lawsuits and violent disturbances. G. Shah argues that caste counts will not weaken the caste system nor expand their political power, but will intensify internal conflicts between the Dalit and Bahujan movements. One other issue is the reintroduction of the 1961 Household schedule which provides family composition by landholding size and household enterprise. Krishnaji advises that this data would help analyze sex ratio imbalances. In 1997, the Core Group examined gender equity issues and operational issues about increasing the scope without increasing costs. The Core Group recommended caste data at the district and sub-district level. Undercounting of the female work force is a continuing issue from the 1991 Census. Suggestions by the Core Group are indicated in brief.

  17. Editorial Volume 6 Issue 3

    Directory of Open Access Journals (Sweden)

    Ciorstan Smark

    2012-09-01

    Full Text Available This issue of AABFJ has several finance articles related to the Australian securities market. Segara, Das and Turner (2012 report results from the use of active extension strategies in the Australian equities market. Lee (2012 examines whether individual hedge funds and funds-of-hedge funds (FOHFs exhibit risk-return trade-off patterns. Finally, Aldamen, Duncan and Khan (2012 explore the impact of corporate governance on the demand for debt in the Australian market. Pickering (2012 explores the issue of whether public (ASX listed or partnership ownership of accounting firms is the more efficient form.

  18. Editorial: Volume 3, Issue 2

    Directory of Open Access Journals (Sweden)

    Kristy Archuleta

    2012-12-01

    Full Text Available In the mid-year issue of the Journal of Financial Therapy, we highlighted the many accomplishments the Journal has made in just three short years. The submissions to the Journal continue to grow, the quality of submissions is increasing, and the diversity of topics is expanding. For example, in this issue, topics of articles are not only specifically related to financial therapy, but also include: (a financial literacy and social work, (b financial coaching, and (c financial trauma and tactical asset management. Seeing the Journal expand and grow is very exciting!

  19. Reproductive issues in anorexia nervosa

    Science.gov (United States)

    Hoffman, Elizabeth R; Zerwas, Stephanie C; Bulik, Cynthia M

    2011-01-01

    Despite a high prevalence of menstrual irregularities, women with anorexia nervosa are becoming pregnant. The physical and psychological demands of pregnancy and motherhood can represent an immense challenge for women already struggling with the medical and psychological stress of an eating disorder. This article summarizes key issues related to reproduction in women with anorexia nervosa, highlighting the importance of preconception counseling, adequate gestational weight gain, and sufficient pre- and post-natal nutrition. Postpartum issues including eating disorder symptom relapse, weight loss, breastfeeding, and risk of perinatal depression and anxiety are also discussed. PMID:22003362

  20. Introducing to the first issue

    Directory of Open Access Journals (Sweden)

    Cesar Acleto

    2014-06-01

    Full Text Available The presentation of the first issue of the REVISTA PERUANA DE BIOLOGíA, as official organ of dissemination of ASOCIACION DE BIOLOGOS DE LA UNIVERSIDAD DE SAN MARCOS, the reverse of the COVER is included with editorial information and BACK COVER with guidelines for authors and the reverse table with the CONTENS.