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Sample records for gro fellows handbook

  1. Myxococcus xanthus DK1622 Coordinates Expressions of the Duplicate groEL and Single groES Genes for Synergistic Functions of GroELs and GroES

    Directory of Open Access Journals (Sweden)

    Yue-zhong Li

    2017-04-01

    Full Text Available Chaperonin GroEL (Cpn60 requires cofactor GroES (Cpn10 for protein refolding in bacteria that possess single groEL and groES genes in a bicistronic groESL operon. Among 4,861 completely-sequenced prokaryotic genomes, 884 possess duplicate groEL genes and 770 possess groEL genes with no neighboring groES. It is unclear whether stand-alone groEL requires groES in order to function and, if required, how duplicate groEL genes and unequal groES genes balance their expressions. In Myxococcus xanthus DK1622, we determined that, while duplicate groELs were alternatively deletable, the single groES that clusters with groEL1 was essential for cell survival. Either GroEL1 or GroEL2 required interactions with GroES for in vitro and in vivo functions. Deletion of groEL1 or groEL2 resulted in decreased expressions of both groEL and groES; and ectopic complementation of groEL recovered not only the groEL but also groES expressions. The addition of an extra groES gene upstream groEL2 to form a bicistronic operon had almost no influence on groES expression and the cell survival rate, whereas over-expression of groES using a self-replicating plasmid simultaneously increased the groEL expressions. The results indicated that M. xanthus DK1622 cells coordinate expressions of the duplicate groEL and single groES genes for synergistic functions of GroELs and GroES. We proposed a potential regulation mechanism for the expression coordination.

  2. New procedures for Fellows nominations

    Science.gov (United States)

    Wood, Eric

    On January 30, 2000, the Union Fellows Committee met and elected 37 new members for Fellowship.The Fellows Committee's selection of Fellows is the last step in a process that begins with the nomination of members by their colleagues.

  3. 2011 Einstein Fellows Chosen

    Science.gov (United States)

    2011-03-01

    ASA has announced the selection of the 2011 Einstein Fellows who will conduct research related to NASA's Physics of the Cosmos program, which aims to expand our knowledge of the origin, evolution, and fate of the Universe. The Einstein Fellowship provides support to the awardees for three years, and the Fellows may pursue their research at a host university or research center of their choosing in the United States. The new Fellows will begin their programs in the fall of 2011. The new Einstein Fellows and their host institutions are listed below: * Akos Bogdan (Smithsonian Astrophysical Observatory, Cambridge, Mass.) * Samuel Gralla (University of Maryland, College Park, Md.) * Philip Hopkins (University of California at Berkeley) * Matthew Kunz (Princeton University, Princeton, N.J.) * Laura Lopez (Massachusetts Institute of Technology, Cambridge, Mass.) * Amy Reines (National Radio Astronomy Observatory, Charlottesville, Virg.) * Rubens Reis (University of Michigan, Ann Arbor) * Ken Shen (Lawrence Berkeley National Laboratory, Berkeley, Calif.) * Jennifer Siegal-Gaskins (California Institute of Technology, Pasadena) * Lorenzo Sironi (Harvard University, Cambridge, Mass.) NASA has two other astrophysics theme-based fellowship programs: the Sagan Fellowship Program, which supports research into exoplanet exploration, and the Hubble Fellowship Program, which supports research into cosmic origins. More information on the Einstein Fellowships can be found at: http://cxc.harvard.edu/fellows/

  4. AGU elects 1989 Fellows

    Science.gov (United States)

    Twenty-two distinguished scientists have been elected Fellows of the Union. Fellows are scientists who are judged by their peers as having attained ackowledged eminence in a branch of geophysics. The number of Fellows elected each year is limited to 0.1 % of the total membership at the time of election. The newly elected Fellows are Walter Alvarez, University of California, Berkeley; John R. Booker, University of Washington, Seattle; Peter G. Brewer, Woods Hole Oceanographie Institution, Woods Hole, Mass.; Michael H. Carr, U.S. Geological Survey, Menlo Park, Calif.; Gedeon Dagan, Tel Aviv University, Israel; James H. Dieterich, USGS, Menlo Park; Thomas Dunne, University of Washington, Seattle; Jack Fooed Evernden, USGS, Menlo Park; Edward A. Flinn, NASA Headquarters, Washington, D.C.; Arnold L. Gordon, Lamont-Doherty Geological Observatory, Palisades, N.Y.; Gerhard Haerendel, Max Planck Institut, Garching, Federal Republic of Germany; David L. Kohlstedt, Cornell University, Ithaca, N.Y.; Robert A. Langel, NASA Goddard Space Flight Center, Greenbelt, MD; James G. Moore, USGS, Menlo Park; Marcia Neugebauer, Jet Propulsion Laboratory, Pasadena, Calif. Robert C. Newton, University of Chicago, Illinois; John A. Orcutt, Scripps Institution of Oceanography, La Jolla, Calif.; Robert B. Smith, University of Utah, Salt Lake City; Bengt U. Sonnerup, Dartmouth College, Hanover, N.H.; Martin A. Uman, University of Florida, Gainesville; Joe Veverka, Cornell University; and James C.G. Walker, University of Michigan, Ann Arbor.

  5. 2004 Fellows Citations

    Science.gov (United States)

    2004-04-01

    AGU congratulates the forty-one distinguished scientists who were selected by a committee of their peers to be AGU Fellows for 2004. This selection was based on the individuals' attainment of acknowledged eminence in a branch of geophysics. The number of Fellows selected annually is limited to no more than 0.1% of the AGU membership: Andrew D. Barry, Enrico Bonatti, Edward V. Bromwell, John P. Burrows, Philip R. Christensen, William B. Curry, Judith Curry, Margaret L. Delaney, Steven R. Emerson, Brian J. Evans, Donald H. Fairfield, Marvin Geller, David Green, William Holt, Roy Hyndman, David E. James, James F. Kasting, Peter Kelemen, Paul J. Kellogg, Michael J. Kirkby, Daniel Loucks, P.M. Mathews, Jean-Paul Montagner, William R. Normark, Gerald R. North, Michael O'Hara, Ronald S. Oremland, Roger A. Pielke, Sr., Joseph Prospero, Karsten Pruess, Edmond C. Roelof, Gary Rottman, Allan Rubin, Ernest H. Rutter, John H. Seinfeld, Sharon Smith, Pieter Tans, John M. Toole, Jean-Pierre Valet, Lionel Wilson, and E. L. Winterer

  6. Brazing handbook

    CERN Document Server

    American Welding Society

    2007-01-01

    By agreement between the American Welding Society C3 Committee on Brazing and Soldering and the ASM Handbook Committee, the AWS Brazing Handbook has been formally adopted as part of the ASM Handbook Series. Through this agreement, the brazing content in the ASM Handbook is significantly updated and expanded. The AWS Brazing Handbook, 5th Edition provides a comprehensive, organized survey of the basics of brazing, processes, and applications. Addresses the fundamentals of brazing, brazement design, brazing filler metals and fluxes, safety and health, and many other topics. Includes new chapters on induction brazing and diamond brazing.

  7. Fellows, Associates & Students Programmes

    CERN Document Server

    2005-01-01

    The present document reviews the CERN Fellows, Associates and Students Programmes emphasizing the developments since 2000, when the previous review was presented to the Scientific Policy Committee, Finance Committee and Council (CERN/2325), and makes proposals for the coming five years. In summary, it is proposed to â?¢ Simplify the payment scheme for the Paid Scientific Associates Programme, which will no longer depend on candidateâ??s home support and age; â?¢ Broaden the scope of the Fellowship Programme, in order to facilitate the recruitment of young graduates in computing and engineering. Age-related eligibility conditions and payment levels will be replaced with experience-based criteria; â?¢ Modify subsistence rates for the Doctoral and Technical Student Programme in order to harmonize CERNâ??s payment levels with those offered by other research establishments. This document is presented for discussion and recommendation by the Scientific Policy Committee and approval by the Council. Additiona...

  8. Fellows Celebrated at Joint Assembly

    Science.gov (United States)

    2007-06-01

    The 2007 AGU Fellows were presented at the recent Joint Assembly in Acapulco, Mexico. A formal ceremony was held on 25 May 2007, where President Tim Killeen introduced each Fellow and read a brief statement of the achievements for which each had been selected. The presentations were followed by an honors fiesta at which family members and close colleagues further feted the honorees.

  9. Fellows Celebrated at Joint Assembly

    Science.gov (United States)

    2009-06-01

    The 2009 AGU Fellows were presented at the recent Joint Assembly in Toronto, Ontario, Canada. At a formal ceremony on 26 May 2009, AGU President Timothy L. Grove introduced each Fellow and read a brief statement of the achievements for which each had been selected. The presentations were followed by a reception for meeting attendees and a banquet at which family members and close colleagues further feted the honorees. AGU Fellows are scientists who have attained “acknowledged eminence in the geophysical sciences.” Election to AGU Fellowship is a very high recognition by one's peers. The number of Fellows elected may not exceed 0.1% of the membership in any given year.

  10. 5 CFR 315.708 - Conversion based on service as a Fellow or Senior Fellow in the Presidential Management Fellows...

    Science.gov (United States)

    2010-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CAREER AND CAREER-CONDITIONAL... Conversion based on service as a Fellow or Senior Fellow in the Presidential Management Fellows Program. (a... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Conversion based on service as a Fellow...

  11. Teacher's Handbook. Peace Corps Language Handbook Series.

    Science.gov (United States)

    Clark, Raymond C.

    This handbook is a general introduction to the handbooks, methods, and materials used in Peace Corps language training classes. The first part of the handbook introduces the reader to the nature of language teaching and gives a general introduction to the handbooks. It also provides a more detailed description of the handbooks on (1) communication…

  12. Crane handbook

    CERN Document Server

    Dickie, D E

    1975-01-01

    Crane Handbook offers extensive advice on how to properly handle a crane. The handbook highlights various safety requirements and rules. The aim of the book is to improve the readers' crane operating skills, which could eventually make the book a standard working guide for training operators. The handbook first reminds the readers that the machine should be carefully tested by a regulatory board before use. The text then notes that choosing the right crane for a particular job is vital and explains why this is the case. It then discusses how well-equipped and durable the crane should be. T

  13. NISE Fellows Program: Feedback from Past Fellows. Occasional Paper.

    Science.gov (United States)

    White, Paula A., Ed.

    The National Institute for Science Education (NISE) is an organization in which scholars from different disciplinary backgrounds work collaboratively to address the important issues in Science, Mathematics, Engineering, and Technology (SMET) education. This document reports on NISE Fellows' experiences based on these questions: (1) How did you…

  14. Employee Handbook

    OpenAIRE

    2008-01-01

    Civilian employee handbook governing Naval Postgraduate School, Naval Auxiliary Landing Field, Fleet Numerical Weather Central, and Navy Management Systems Center, and covering expected personal conduct, duties, dress code, and available services.

  15. Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES

    Science.gov (United States)

    Chi, Haixia; Wang, Xiaoqiang; Li, Jiqiang; Ren, Hao; Huang, Fang

    2015-11-01

    The in vitro folding of newly translated human CC chemokine receptor type 5 (CCR5), which belongs to the physiologically important family of G protein-coupled receptors (GPCRs), has been studied in a cell-free system supplemented with the surfactant Brij-35. The freshly synthesized CCR5 can spontaneously fold into its biologically active state but only slowly and inefficiently. However, on addition of the GroEL-GroES molecular chaperone system, the folding of the nascent CCR5 was significantly enhanced, as was the structural stability and functional expression of the soluble form of CCR5. The chaperonin GroEL was partially effective on its own, but for maximum efficiency both the GroEL and its GroES lid were necessary. These results are direct evidence for chaperone-assisted membrane protein folding and therefore demonstrate that GroEL-GroES may be implicated in the folding of membrane proteins.

  16. GRoW Buffalo Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Bohm, Martha [Univ. at Buffalo, NY (United States)

    2016-04-17

    This document provides final reporting on the GRoW Home, University at Buffalo's entry to the 2015 Solar Decathlon competition in Irvine, CA. The report summarizes fundraising efforts, documents media outreach, lists online presence, analyzes the organizer's communication, describes post-competition life of the house and future employment plans for student team members. Last, it suggests improvements for future decathlons.

  17. Decommissioning Handbook

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Decommissioning Handbook is a technical guide for the decommissioning of nuclear facilities. The decommissioning of a nuclear facility involves the removal of the radioactive and, for practical reasons, hazardous materials to enable the facility to be released and not represent a further risk to human health and the environment. This handbook identifies and technologies and techniques that will accomplish these objectives. The emphasis in this handbook is on characterization; waste treatment; decontamination; dismantling, segmenting, demolition; and remote technologies. Other aspects that are discussed in some detail include the regulations governing decommissioning, worker and environmental protection, and packaging and transportation of the waste materials. The handbook describes in general terms the overall decommissioning project, including planning, cost estimating, and operating practices that would ease preparation of the Decommissioning Plan and the decommissioning itself. The reader is referred to other documents for more detailed information. This Decommissioning Handbook has been prepared by Enserch Environmental Corporation for the US Department of Energy and is a complete restructuring of the original handbook developed in 1980 by Nuclear Energy Services. The significant changes between the two documents are the addition of current and the deletion of obsolete technologies and the addition of chapters on project planning and the Decommissioning Plan, regulatory requirements, characterization, remote technology, and packaging and transportation of the waste materials.

  18. Progress in molecular chaperon GroEL%GroEL分子伴侣研究进展

    Institute of Scientific and Technical Information of China (English)

    张经余; 赵志虎; 蔡民华

    2001-01-01

    大肠杆菌的GroEL是同型寡聚复合体,由14个相对分子质量58×103亚基组成背靠背的双环结构。它在新生蛋白质的正确折叠和组装以及在热或化学逆境下变性蛋白质的恢复过程中起重要作用。同时,在大肠杆菌的跨膜转运及插入细胞质膜方面都起重要作用。这些活动依赖于GroEL与底物蛋白的疏水片断的相互作用。综述了Hsp60分子伴侣系统中研究得比较清楚的GroEL的晶体结构、功能及作用机理等方面的研究进展。%Molecular chaperon GroEL of E.coli is a homo-oligomeric complex composed of 14 58kDa subunits arranged in two rings stacked back to back, which is required for correct folding and assambly of newly synthesized proteins and for recovery of the cell after exposure to either thermal or chemical stress .Apart from these functions, GroEL chaperon is able to play a role in protein translocation across or insertion into the cytoplasmic membrane of E.coli. These actions depend on the interaction between GroE chaperionin system and the hydrophobic side chains .

  19. Employee Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Bello, Madelyn

    2008-09-05

    Welcome to Berkeley Lab. You are joining or are already a part of a laboratory with a sterling tradition of scientific achievement, including eleven Nobel Laureates and thirteen National Medal of Science winners. No matter what job you do, you make Berkeley Lab the outstanding organization that it is. Without your hard work and dedication, we could not achieve all that we have. We value you and thank you for choosing to be part of our community. This Employee Handbook is designed to help you navigate the Lab. With over 3,000 employees, an additional 3,000 guests visiting from countries around the world, a 200-acre campus and many policies and procedures, learning all the ins and outs may seem overwhelming, especially if you're a new employee. However, even if you have been here for a while, this Handbook should be a useful reference tool. It is meant to serve as a guide, highlighting and summarizing what you need to know and informing you where you can go for more detailed information. The general information provided in this Handbook serves only as a brief description of many of the Lab's policies. Policies, procedures and information are found in the Lab's Regulations and Procedures Manual (RPM), Summary Plan Descriptions, University of California policies, and provisions of Contract 31 between the Regents of the University and the U.S. Department of Energy. In addition, specific terms and conditions for represented employees are found in applicable collective bargaining agreements. Nothing in this Handbook is intended to supplant, change or conflict with the previously mentioned documents. In addition, the information in this Handbook does not constitute a contract or a promise of continued employment and may be changed at any time by the Lab. We believe employees are happier and more productive if they know what they can expect from their organization and what their organization expects from them. The Handbook will familiarize you with the

  20. Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein

    DEFF Research Database (Denmark)

    Tang, Sheila Tuyet; Chang, HC; Roeben, A

    2006-01-01

    GroEL and GroES form a chaperonin nano-cage for proteins up to similar to 60 kDa to fold in isolation. Here we explored the structural features of the chaperonin cage critical for rapid folding of encapsulated substrates. Modulating the volume of the GroEL central cavity affected folding speed....... Additionally, interactions with the C-terminal, mildly hydrophobic Gly-Gly-Met repeat sequences of GroEL protruding into the cavity, and repulsion effects from the negatively charged cavity wall were required for rapid folding of some proteins. We suggest that by combining these features, the chaperonin cage...

  1. IFSIM Handbook

    OpenAIRE

    Baroni, Elisa; Zamac, Jovan; Öberg, Gustav

    2009-01-01

    This handbook explains the simulation model IFSIM. IFSIM is an agent based simulation model written in JAVA. The model is constructed for analyzing demographic and economic issues. The aim of the model is to include the main consumption and production patterns over the life-cycle and thus being able to test demo-economic interactions.

  2. Ambulance Handbook

    Science.gov (United States)

    1976-01-01

    Johnson Space Center has devised a checklist for the skylab inflight medical support system that has been transferred for public emergencies. The checklist illustrates a procedure for diagnosis, treatment, and stabilization of a wide variety of emergencies. Handbook presents comprehensive ordered description of emergency medical equipment and its use in treating victims. Paramedics assigned to the Houston Fire Department are now using the checklist.

  3. Sequence analysis of the Legionella micdadei groELS operon

    DEFF Research Database (Denmark)

    Hindersson, P; Høiby, N; Bangsborg, Jette Marie

    1991-01-01

    shock expression signals were identified upstream of the L. micdadei groEL gene. Further upstream, a poly-T region, also a feature of the sigma 32-regulated Escherichia coli groELS heat shock operon, was found. Despite the high degree of homology of the expression signals in E. coli and L. micdadei...

  4. Fellow's Apéro

    CERN Multimedia

    Staff Association

    2017-01-01

    Let's get together, meet each other, exchange experiences and ideas, and share useful information on CERN and the Staff Association. Join us for Fellow's Apéro, organised by the Staff Association on Tuesday 21 February at 16.30 in Restaurant 1. There will be drinks and snacks for everybody! We look forward to seeing you there! Please confirm your participation on Doodle http://doodle.com/poll/skvm7ucm2z78i6bt or alternatively on Facebook https://www.facebook.com/events/1862757017340069/. Your delegates in the Staff Association, Barbora & Jiri

  5. Public health lives: Gro Harlem Brundtland.

    Science.gov (United States)

    Yach, D; von Schirnding, Y

    2014-02-01

    Health has been a deeply personal, professional and political dimension of Gro Harlem Brundtland's life. Her decision to study breast feeding while an MPH student at Harvard in 1964, or her desire to tackle tobacco being influenced by her father sending her as a 10-year old girl to buy his cigarettes at the local store, or her deeply personal family experience of mental ill health all led her to take actions on the global stage to address these and other issues that evidence showed would have global impact. Her impact on global health started with a commitment to make a difference in the lives of people, particularly those in greatest need. Copyright © 2013 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  6. Econometric Fellows and Nobel Laureates in Economics

    OpenAIRE

    Ho Fai Chan; Benno Torgler

    2012-01-01

    An academic award is method by which peers offer recognition of intellectual efforts. In this paper we take a purely descriptive look at the relationship between becoming a Fellow of the Econometric Society and receiving the Nobel Prize in economics. We discover some interesting aspects: of all 69 Nobel Prize Laureates between 1969 and 2011, only 9 of them were not also Fellows. Moreover, the proportion of future Nobel winners among the Fellows has been quite high throughout time and a large ...

  7. Report on the 2009 ESO Fellows Symposium

    Science.gov (United States)

    Emsellem, Eric; West, Michael; Leibundgut, Bruno

    2009-09-01

    The fourth ESO Fellows Symposium took place in Garching from 8-10 June 2009. This year's symposium brought together 28 ESO Fellows from Chile and Germany to meet their colleagues from across the ocean, discuss their research and provide feedback on ESO's Fellowship programme. This year's symposium also included training workshops to enhance the practical skills of ESO Fellows in today's competitive job market.

  8. Loudspeaker handbook

    CERN Document Server

    Eargle, John

    2003-01-01

    The second edition of Loudspeaker Handbook follows the same general outlines as the highly successful first edition and has been augmented and updated in many areas of technology. Most notable are the developments in large-scale, programmable line arrays, distributed mode loudspeakers, and ultrasonic-based audio transduction. Additionally, the core chapters on low frequency systems, system concepts, and horn systems have been expanded to include both more analytical material and a richer array of examples. Much of the success of the first edition has been due to its accessibility both to loudspeaker engineers and to lay technicians working in the field - a point of view the author maintains in the present work. A full understanding of the underlying technology requires a fairly rigorous engineering background through the second year of professional study. At the same time, the generous use of graphs, with their intuitive thrust, will be useful to all readers. Loudspeaker Handbook, Second Edition continues to ...

  9. Nanobiomaterials handbook

    CERN Document Server

    Sitharaman, Balaji

    2011-01-01

    Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they are poised to play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Nanobiomaterials Handbook provides a comprehensive overview of the field, offering a broad introduction for those new to the subject as well as a useful reference for advanced professionals.Analyzing major topics and disciplines in this arena, this volume:

  10. GroEL of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31 exhibits GroES and ATP-independent refolding activity.

    Science.gov (United States)

    Potnis, Akhilesh A; Rajaram, Hema; Apte, Shree K

    2016-03-01

    The nitrogen-fixing cyanobacterium, Anabaena L-31 has two Hsp60 proteins, 59 kDa GroEL coded by the second gene of groESL operon and 61 kDa Cpn60 coded by cpn60 gene. Anabaena GroEL formed stable higher oligomer (>12-mer) in the presence of K(+) and prevented thermal aggregation of malate dehydrogenase (MDH). Using three protein substrates (MDH, All1541 and green fluorescent protein), it was found that the refolding activity of Anabaena GroEL was lower than that of Escherichia coli GroEL, but independent of both GroES and ATP. This correlated with in vivo data. GroEL exhibited ATPase activity which was enhanced in the presence of GroES and absence of a denatured protein, contrary to that observed for bacterial GroEL. However, a significant role for ATP could not be ascertained during in vitro folding assays. The monomeric Cpn60 exhibited much lower refolding activity than GroEL, unaffected by GroES and ATP. In vitro studies revealed inhibition of the refolding activity of Anabaena GroEL by Cpn60, which could be due to their different oligomeric status. The role of GroES and ATP may have been added during the course of evolution from the ancient cyanobacteria to modern day bacteria enhancing the refolding ability and ensuring wider scope of substrates for GroEL.

  11. Dataset concerning GroEL chaperonin interaction with proteins

    Directory of Open Access Journals (Sweden)

    V.V. Marchenkov

    2016-03-01

    Full Text Available GroEL chaperonin is well-known to interact with a wide variety of polypeptide chains. Here we show the data related to our previous work (http://dx.doi.org/10.1016/j.pep.2015.11.020 [1], and concerning the interaction of GroEL with native (lysozyme, α-lactalbumin and denatured (lysozyme, α-lactalbumin and pepsin proteins in solution. The use of affinity chromatography on the base of denatured pepsin for GroEL purification from fluorescent impurities is represented as well.

  12. Fellow As Teacher Curriculum: Improving Rheumatology Fellows' Teaching Skills During Inpatient Consultation.

    Science.gov (United States)

    Miloslavsky, Eli M; Criscione-Schreiber, Lisa G; Jonas, Beth L; O'rourke, Kenneth S; McSparron, Jakob I; Bolster, Marcy B

    2016-06-01

    Enhancing rheumatology fellows' teaching skills in the setting of inpatient consultation may have a broad positive impact. Such efforts may improve fellows' clinical skills and overall patient care. Most importantly, effective resident-fellow teaching interactions may not only increase residents' knowledge of rheumatology but may influence their career choice. However, a number of barriers to the resident-fellow teaching interaction have been identified, including fellows' teaching skills. We developed the Fellow As Clinical Teacher (FACT) curriculum in order to enhance fellows' teaching skills during inpatient consultation. The FACT curriculum was delivered in two 45-minute workshops during the 3-day Winter Symposium of the Carolinas Fellows Collaborative. We evaluated its effect with self-assessment surveys and fellow performance on the objective structured teaching exercise (OSTE) before and after participation in the curriculum. Nineteen fellows from 4 rheumatology training programs participated in the pre- and post-curriculum OSTEs and 18 fellows completed pre- and post-curriculum surveys. OSTE scores improved on 5 of the 8 items assessed, and the total OSTE score improved as well (34.7 versus 29.5; P Rheumatology.

  13. Strategisches Informationsmanagement in Großprojekten der Industrie

    OpenAIRE

    Gemmel, Gunter

    2013-01-01

    Unternehmen gründen Projekte, um einmalige, zeitlich begrenzte Vorhaben effizient zu realisieren. Gerade in der Industrie zeigt sich diese Vorgehensweise häufig in Form von Großprojekten. Das IT-Management zur Unterstützung dieser Industrieprojekte steht dabei vor besonderen, charakteristischen Herausforderungen. Diese Arbeit beantwortet die Forschungsfrage, wie die bestehenden Konzepte des strategi- schen Informationsmanagements im speziellen Kontext von Großprojekten der Industrie angewe...

  14. Nanomaterials handbook

    CERN Document Server

    Gogotsi, Yury

    2006-01-01

    Even before it was identified as a science and given a name,  nanotechnology was the province of the most innovative inventors. In medieval times, craftsmen, ingeniously employing nanometer-sized gold particles, created the enchanting red hues found in the gold ruby glass of cathedral windows. Today, nanomaterials are being just as creatively used to improve old products, as well as usher in new ones. From tires to CRTs to sunscreens, nanomaterials are becoming a part of every industry. The Nanomaterials Handbook provides a comprehensive overview of the current state of nanomaterials. Employ

  15. Geothermal Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Leffel, C.S., Jr.; Eisenberg, R.A.

    1977-06-01

    This handbook is intended to assist the physicist, chemist, engineer, and geologist engaged in discovering and developing geothermal energy resources. This first section contains a glossary of the approximately 500 most frequently occurring geological, physical, and engineering terms, chosen from the geothermal literature. Sections 2 through 8 are fact sheets that discuss such subjects as geothermal gradients, rock classification, and geological time scales. Section 9 contains conversion tables for the physical quantities of interest for energy research in general and for geothermal research in particular.

  16. Training Psychiatry Addiction Fellows in Acupuncture

    Science.gov (United States)

    Serafini, Kelly; Bryant, Katurah; Ikomi, Jolomi; LaPaglia, Donna

    2015-01-01

    Objective Acupuncture has been studied as an adjunct for addictions treatment. Because many hospitals, outpatient clinics, and facilities are integrating acupuncture treatment, it is important that psychiatrists remain informed about this treatment. This manuscript describes the National Acupuncture Detoxification Association (NADA) protocol and its inclusion as part of the curriculum for psychiatry addictions fellows. Methods Psychiatry and psychology fellows completed the NADA training (N = 20) and reported on their satisfaction with the training. Results Overall, participants stated that they found the training beneficial and many were integrating acupuncture within their current practice. Conclusions Results support the acceptability of acupuncture training among psychiatry fellows in this program. PMID:26048457

  17. Handbook of systems toxicology

    National Research Council Canada - National Science Library

    Casciano, Daniel A; Sahu, Saura C

    2011-01-01

    "In the first handbook to comprehensively cover the emerging area of systems toxicology, the Handbook of Systems Toxicology provides an authoritative compilation of up-to-date developments presented...

  18. GUO Lei honored as IFAC Fellow

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Prof. GUO Lei, an expert in systems science with the Academy of Mathematics and Systems Science (AMSS) under CAS, was recently elected a Fellow of International Federation of Autonomic Control (IFAC).

  19. Mechanical engineer's handbook

    CERN Document Server

    Marghitu, Dan B

    2001-01-01

    The Mechanical Engineer's Handbook was developed and written specifically to fill a need for mechanical engineers and mechanical engineering students throughout the world. With over 1000 pages, 550 illustrations, and 26 tables the Mechanical Engineer's Handbook is very comprehensive, yet affordable, compact, and durable. The Handbook covers all major areas of mechanical engineering with succinct coverage of the definitions, formulas, examples, theory, proofs, and explanations of all principle subject areas. The Handbook is an essential, practical companion for all mechanic

  20. Semiconductors data handbook

    CERN Document Server

    Madelung, Otfried

    2004-01-01

    This volume Semiconductors: Data Handbook contains frequently used data from the corresponding larger Landolt-Börnstein handbooks in a low price book for the individual scientist working in the laboratory. The Handbook contain important information about a large number of semiconductors

  1. GroEL mediates protein folding with a two successive timer mechanism.

    Science.gov (United States)

    Ueno, Taro; Taguchi, Hideki; Tadakuma, Hisashi; Yoshida, Masasuke; Funatsu, Takashi

    2004-05-21

    GroEL encapsulates nonnative substrate proteins in a central cavity capped by GroES, providing a safe folding cage. Conventional models assume that a single timer lasting approximately 8 s governs the ATP hydrolysis-driven GroEL chaperonin cycle. We examine single molecule imaging of GFP folding within the cavity, binding release dynamics of GroEL-GroES, ensemble measurements of GroEL/substrate FRET, and the initial kinetics of GroEL ATPase activity. We conclude that the cycle consists of two successive timers of approximately 3 s and approximately 5 s duration. During the first timer, GroEL is bound to ATP, substrate protein, and GroES. When the first timer ends, the substrate protein is released into the central cavity and folding begins. ATP hydrolysis and phosphate release immediately follow this transition. ADP, GroES, and substrate depart GroEL after the second timer is complete. This mechanism explains how GroES binding to a GroEL-substrate complex encapsulates the substrate rather than allowing it to escape into solution.

  2. The RSNA Editorial Fellows: Then and Now.

    Science.gov (United States)

    Lee, Edward Y; Guglielmi, Giuseppe; Katz, Douglas S

    2015-09-01

    Since its establishment in 1998, the Radiological Society of North America (RSNA) Editorial Fellowship has been offering unique opportunities to radiologists from around the world who have a strong interest in radiologic journalism. For the past 16 years, the selected RSNA Editorial Fellows have learned essential processes involved in the production of Radiology and RadioGraphics by working closely with the editors, associate editors, and staff. The editorial fellowship for radiology attending physicians was renamed the RSNA William R. Eyler Editorial Fellowship, in honor of the founding editor of RadioGraphics, with the first Eyler fellow selected in 2005. Additionally, several years ago, a second fellowship was created for radiology trainees, which is now named the RSNA William W. Olmsted Editorial Fellowship for Trainees, in honor of the most recent emeritus editor of RadioGraphics. For the special centennial year of the journal Radiology, several former editorial fellows were interested in knowing what the previous fellows are up to presently and how their experience and learning from the fellowship influenced and contributed to their academic career development. The invitation to share their experience of the RSNA Editorial Fellowship was sent to 19 previous RSNA Editorial Fellows. We report the findings from 16 of these fellows who responded. We found that almost all previous RSNA Editorial Fellows (15 of 16, 94%) stayed in academic radiology, and each is currently leading a successful academic career. All of them are currently actively serving in one or more positions as an editor, associate editor, reviewer, and/or editorial board member of various radiology journals and clinical journals related to their area(s) of academic expertise. Among the 16 previous editorial fellows who responded, there are four chairs and six vice-chairs of their respective radiology departments. All of them reported that the experience and knowledge they gained from the RSNA

  3. Competency Testing for Pediatric Cardiology Fellows Learning Transthoracic Echocardiography: Implementation, Fellow Experience, and Lessons Learned.

    Science.gov (United States)

    Levine, Jami C; Geva, Tal; Brown, David W

    2015-12-01

    There is currently great interest in measuring trainee competency at all levels of medical education. In 2007, we implemented a system for assessing cardiology fellows' progress in attaining imaging skills. This paradigm could be adapted for use by other cardiology programs. Evaluation consisted of a two-part exercise performed after years 1 and 2 of pediatric cardiology training. Part 1: a directly observed evaluation of technical skills as fellows imaged a normal subject (year 1) and a patient with complex heart disease (year 2). Part 2: fellows interpreted and wrote reports for two echocardiograms illustrating congenital heart disease. These were graded for accuracy and facility with communicating pertinent data. After 5 years of testing, fellows were surveyed about their experience. In 5 years, 40 fellows were tested at least once. Testing identified four fellows who underperformed on the technical portion and four on the interpretive portion. Surveys were completed by 33 fellows (83 %). Most (67 %) felt that intermittent observation by faculty was inadequate for assessing skills and that procedural volume was a poor surrogate for competency (58 %). Posttest feedback was constructive and valuable for 90, and 70 % felt the process helped them set goals for skill improvement. Overall, fellows felt this testing was fair and should continue. Fellow performance and responses identified programmatic issues that were creating barriers to learning. We describe a practical test to assess competency for cardiology fellows learning echocardiography. This paradigm is feasible, has excellent acceptance among trainees, and identifies trainees who need support. Materials developed could be easily adapted to help track upcoming ACGME-mandated metrics.

  4. Decommissioning handbook

    Energy Technology Data Exchange (ETDEWEB)

    Manion, W.J.; LaGuardia, T.S.

    1980-11-01

    This document is a compilation of information pertinent to the decommissioning of surplus nuclear facilities. This handbook is intended to describe all stages of the decommissioning process including selection of the end product, estimation of the radioactive inventory, estimation of occupational exposures, description of the state-of-the-art in re decontamination, remote csposition of wastes, and estimation of program costs. Presentation of state-of-the-art technology and data related to decommissioning will aid in consistent and efficient program planning and performance. Particular attention is focused on available technology applicable to those decommissioning activities that have not been accomplished before, such as remote segmenting and handling of highly activated 1100 MW(e) light water reactor vessel internals and thick-walled reactor vessels. A summary of available information associated with the planning and estimating of a decommissioning program is also presented. Summarized in particular are the methodologies associated with the calculation and measurement of activated material inventory, distribution, and surface dose level, system contamination inventory and distribution, and work area dose levels. Cost estimating techniques are also presented and the manner in which to account for variations in labor costs as impacting labor-intensive work activities is explained.

  5. Manuelle Montage von Großgeräten

    Science.gov (United States)

    Lotter, Bruno

    Die manuelle Montage von Großgeräten — wie. z. B. Maschinen, Traktoren, Haushaltsgeräte, PKW-Motoren, LKW-Achsen, Schaltschränke usw. — wird in ihrer Montagestruktur vorrangig durch das Produktgewicht, die Produktabmessung und die Produktionsrate bestimmt.

  6. Probing the dynamic process of encapsulation in Escherichia coli GroEL.

    Directory of Open Access Journals (Sweden)

    Toshifumi Mizuta

    Full Text Available Kinetic analyses of GroE-assisted folding provide a dynamic sequence of molecular events that underlie chaperonin function. We used stopped-flow analysis of various fluorescent GroEL mutants to obtain details regarding the sequence of events that transpire immediately after ATP binding to GroEL and GroEL with prebound unfolded proteins. Characterization of GroEL CP86, a circularly permuted GroEL with the polypeptide ends relocated to the vicinity of the ATP binding site, showed that GroES binding and protection of unfolded protein from solution is achieved surprisingly early in the functional cycle, and in spite of greatly reduced apical domain movement. Analysis of fluorescent GroEL SR-1 and GroEL D398A variants suggested that among other factors, the presence of two GroEL rings and a specific conformational rearrangement of Helix M in GroEL contribute significantly to the rapid release of unfolded protein from the GroEL apical domain.

  7. Differential T-cell recognition of native and recombinant Mycobacterium tuberculosis GroES

    DEFF Research Database (Denmark)

    Rosenkrands, I; Weldingh, K; Ravn, P

    1999-01-01

    Mycobacterium tuberculosis GroES was purified from culture filtrate, and its identity was confirmed by immunoblot analysis and N-terminal sequencing. Comparing the immunological recognition of native and recombinant GroES, we found that whereas native GroES elicited a strong proliferative response...

  8. Handbook for Policymackers

    DEFF Research Database (Denmark)

    Jensen, Ulla Højmark

    2016-01-01

    The purpose of the handbook is to support policy makers / decision makers by enabling them to make informed decisions about funding for second chance education or the adoption of its methods into mainstream education. The Handbook makes policy recommendations and provides guidelines to structure...... a quality assurance system that evidences success factors of second chance education and the value of informal learning. The handbook draws on the results of the literature review, the development of the quality assurance system (SMS system), the Teachers Handbook and the Organisational Handbook....... These are available on the SMART project website at www.edu-smart.eu. The guidelines in this handbook will provide policy makers with the rationale for setting up monitoring and self evaluation systems makes recommendations and provides a structure that facilitates evidencing and justification of success factors...

  9. Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses

    DEFF Research Database (Denmark)

    Goltermann, Lise; Sarusie, Menachem V; Bentin, Thomas

    2016-01-01

    Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short-ter...... mechanism for emergence of antibiotic resistance.......Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short......-term tolerance, respectively, to this drug class. Here, we show that chaperonin GroEL/GroES over-expression accelerates acquisition of streptomycin resistance and reduces susceptibility to several other antibiotics following sub-lethal streptomycin antibiotic exposure. Chaperonin buffering could provide a novel...

  10. FINODEX Handbook for Entrepreneurs

    DEFF Research Database (Denmark)

    The handbook provides short introductions to necessary knowledge for applicants in the two calls in October 2014 and June 2015 where they can present an idea for product development and apply for up to 10,000 Euro. Furthermore, the handbook is relevant for the next phase, where the selected approx....... 50 projects elaborate detailed technical and market plans. Last, the handbook provides links to further study and information about how to get help in later phases....

  11. Energy Efficiency Governance: Handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This handbook has been written to assist EE practitioners, government officials and stakeholders to establish effective EE governance structures for their country. The handbook provides readers with relevant information in an accessible format that will help develop comprehensive and effective governance mechanisms. For each of the specific topics dealt with (see Figure 1 in the Handbook), the IEA offers guidelines for addressing issues, or directs readers to examples of how such issues have been dealt with by specific countries.

  12. Chaperonin GroEL/GroES over-expression promotes multi-drug resistance in E. coli following exposure to aminoglycoside antibiotics

    Directory of Open Access Journals (Sweden)

    Lise eGoltermann

    2016-01-01

    Full Text Available Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antiobiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and overexpression sensitize and promote short-term tolerance, respectively, to this drug class. Here we show that chaperonin GroEL/GroES over-expression accelerates acquisition of aminoglycoside resistance and multi-drug resistance following sub-lethal aminoglycoside antibiotic exposure. Chaperonin buffering could provide a novel mechanism for antibiotic resistance and multi-drug resistance development.

  13. Geothermal handbook

    Science.gov (United States)

    1976-01-01

    The Bureau of Land Management offered over 400,000 hectares (one million acres) for geothermal exploration and development in 1975, and figure is expected to double this year. The Energy Research and Development Administration hopes for 10-15,000 megawatts of geothermal energy by 1985, which would require, leasing over 16.3 million hectares (37 million acres) of land, at least half of which is federal land. Since there is an 8 to 8-1/2 year time laf between initial exploration and full field development, there would have to be a ten-fold increase in the amount of federal land leased within the next three years. Seventy percent of geothermal potential, 22.3 million hectares (55 million acres), is on federal lands in the west. The implication for the Service are enormous and the problems immediate. Geothermal resource are so widespread they are found to some extent in most biomes and ecosystems in the western United States. In most cases exploitation and production of geothermal resources can be made compatible with fish and wildlife management without damage, if probable impacts are clearly understood and provided for before damage has unwittingly been allowed to occur. Planning for site suitability and concern with specific operating techniques are crucial factors. There will be opportunities for enhancement: during exploration and testing many shallow groundwater bodies may be penetrated which might be developed for wildlife use. Construction equipment and materials needed for enhancement projects will be available in areas heretofore considered remote projects will be available in areas heretofore considered remote by land managers. A comprehensive knowledge of geothermal development is necessary to avoid dangers and seize opportunities. This handbook is intended to serve as a working tool in the field. It anticipated where geothermal resource development will occur in the western United States in the near future. A set of environmental assessment procedures are

  14. Direct Versus Indirect Supervision of Fellows Covering Football Events: A Survey of Fellows and Program Directors

    Science.gov (United States)

    Lascano, Charles A.; Stovak, Mark L.; Harvey, A. T.

    2010-01-01

    Background The Accreditation Council for Graduate Medical Education (ACGME) program requirements mandate “adequate supervision,” of residents, but there is little guidance for sports medicine fellowship directors regarding the transition from direct to indirect supervision of fellows covering football games. Objective We sought to gather evidence of current supervision practices in the context of injury outcomes. Methods Fellows and program directors of ACGME-accredited sports medicine fellowship programs were invited to complete an online survey regarding their experience and current supervision practice at football games. Criteria for transition to autonomy and desired changes in supervision practice were elicited. Player safety was quantified by noting the number of field-side emergencies, whether an attending was present, and whether better outcomes might have resulted from the presence of an attending. Results A total of 80 fellows and 50 program directors completed the online survey. Direct supervision was lacking in about 50% of high school games and 20% of college games. A resulting cost in terms of player safety was estimated to apply to 5% of serious injuries by fellows' report but less than 0.5% by directors' report. Written criteria for transitioning from direct supervision to autonomy were the exception rather than the rule. The majority of fellows and directors expressed satisfaction with the current level of supervision, but 20% of fellows would prefer more supervision through postgame review. Conclusions Football games covered by fellows are often not directly supervised. Absence of an attending affected the outcomes of 5% or less of serious injuries. Transition to autonomy does not usually require meeting written criteria. Fellows might benefit from additional off-site supervision. PMID:21976096

  15. Cloning and characterization of groESL operon in Acetobacter aceti.

    Science.gov (United States)

    Okamoto-Kainuma, Akiko; Yan, Wang; Kadono, Sachiko; Tayama, Kenji; Koizumi, Yukimichi; Yanagida, Fujiharu

    2002-01-01

    The groESL operon of Acetobacter aceti was cloned and sequenced. We observed that GroES and GroEL of A. aceti had high amino acid sequence homologies to GroES and GroEL of Escherichia coli and Bacillus subtilis. The upstream region of the groESL operon contained the heat-shock promoter, which was previously reported in alpha-purple proteobacteria, and the highly conserved inverted repeat sequence. Phylogenetic analysis revealed that the A. aceti GroES and GroEL are very closely related to those of other alpha-purple proteobacteria. Transcription of this operon in A. aceti was induced by heat shock as well as by exposure to ethanol and acetic acid, which are present during fermentation of acetic acid. A. aceti that overexpressed the groESL was more resistant than the control strain to Stressors such as heat, ethanol, or acetic acid, indicating that GroES and GroEL are closely associated with the characteristic nature of Acetobacter and play an important role in acetic acid fermentation.

  16. Mimicking the action of GroEL in molecular dynamics simulations : Application to the refinement of protein structures

    NARCIS (Netherlands)

    Fan, H; Mark, AE

    2006-01-01

    Bacterial chaperonin, GroEL, together with its co-chaperonin, GroES, facilitates the folding of a variety of polypeptides. Experiments suggest that GroEL stimulates protein folding by multiple cycles of binding and release. Misfolded proteins first bind to an exposed hydrophobic surface on GroEL. Gr

  17. Handbook of Social Capital

    DEFF Research Database (Denmark)

    The Handbook of Social Capital balances the ‘troika' of sociology, political science and economics by offering important contributions to the study of bonding and bridging social capital networks. This inter-disciplinary Handbook intends to serve as a bridge for students and scholars within all...

  18. Research grant handbook

    Science.gov (United States)

    1993-01-01

    This handbook prescribes policies and procedures relating to the award and administration of NASA research grants and cooperative agreements with educational institutions and other nonprofit organizations. The handbook is divided into six subparts: (1) general; (2) definitions; (3) the process; (4) provisions and special conditions; (5) administration; and (6) reports. The appendix includes a listing of exhibits.

  19. Consumer's Resource Handbook.

    Science.gov (United States)

    Office of Consumer Affairs, Washington, DC.

    This handbook is intended to help consumers exercise their rights in the marketplace in three ways. It shows how to communicate more effectively with manufacturers, retailers, and service providers; it is a self-help manual for resolving individual consumer complaints; and it lists helpful sources of assistance. The handbook has two sections. Part…

  20. Customs Modernization Handbook

    OpenAIRE

    De Wulf, Luc; Sokol, José B.

    2005-01-01

    This handbook aims to make a positive contribution to the efforts that many countries are undertaking to modernize their customs administrations. The handbook views a competent and well-organized customs service as one that successfully balances its various responsibilities to ensure a high level of compliance with revenue objectives and regulatory requirements while at the same time inter...

  1. Warehouse Sanitation Workshop Handbook.

    Science.gov (United States)

    Food and Drug Administration (DHHS/PHS), Washington, DC.

    This workshop handbook contains information and reference materials on proper food warehouse sanitation. The materials have been used at Food and Drug Administration (FDA) food warehouse sanitation workshops, and are selected by the FDA for use by food warehouse operators and for training warehouse sanitation employees. The handbook is divided…

  2. Rockin' Readers Handbook.

    Science.gov (United States)

    Alachua County Schools, Gainesville, FL.

    Designed for use by volunteers in the program, this handbook describes the "Rockin' Readers" program, in which senior-citizen volunteers are matched with specifically targeted at-risk children in Alachua County, Florida, who tested below their peer group in language development and reading readiness skills. The handbook notes that each…

  3. Area Handbook for Honduras.

    Science.gov (United States)

    Blutstein, Howard I.; And Others

    This volume is one of 62 in a series of handbooks designed to be useful to military and other personnel who need a convenient compilation of basic facts about social, economic, political, and military institutions and practices of various countries. This handbook seeks to supply an integrated and comprehensive exposition and analysis of the entire…

  4. Report on the ESO Fellows Days in Chile 2011

    Science.gov (United States)

    West, M.; Emsellem, E.

    2012-03-01

    The 2011 ESO Fellows Days were held in Chile and brought together over 30 ESO Fellows from Garching and Chile. As well as presentations of research and social activities, the Fellows Days included a visit to San Pedro de Atacama and the ALMA site.

  5. The runaway black hole GRO J1655-40

    CERN Document Server

    Mirabel, I F; Rodrigues, I; Combi, J A; Rodríguez, L F; Guglielmetti, F

    2002-01-01

    We have used the Hubble Space Telescope to measure the motion in the sky and compute the galactocentric orbit of the black hole X-ray binary GRO J1655-40. The system moves with a runaway space velocity of $112\\pm 18$ km s$^{-1}$ in a highly eccentric ($e = 0.34\\pm 0.05$) orbit. The black hole was formed in the disk at a distance greater than 3 kpc from the Galactic centre and must have been shot to such an eccentric orbit by the explosion of the progenitor star. The runaway linear momentum and kinetic energy of this black hole binary are comparable to those of solitary neutron stars and millisecond pulsars. GRO J1655-40 is the first black hole for which there is evidence for a runaway motion imparted by a natal kick in a supernova explosion.

  6. Student perceptions of clerkship handbooks.

    Science.gov (United States)

    Atherley, Anique; Taylor, Charles

    2017-08-01

    When students transition into new clerkships, it can be useful to provide them with information to assist them in their adjustment to the new social environment. Handbooks could support students by providing information, particularly during clerkship orientation. The authors explored aspects of existing handbooks that students found useful, and sought additional desirable content. During seven semi-structured focus group discussions, 48 final-year medical students discussed their perceptions of six handbooks at the end of their training. Focus group discussions continued until data saturation. Transcripts were thematically analysed. Students appreciated handbooks that were concise, and valued reviewing handbooks with faculty members who could highlight important content. Most students valued and desired content related to assessment, and specifically used handbooks when preparing for examinations. Most students appreciated handbooks that provided study guidance such as a syllabus. Students also appreciated logistical aspects such as a timetable and information on clerkship cultural norms. Students disliked handbooks with vague descriptions of faculty member expectations and students' roles. Students liked, disliked and desired many aspects of clerkship handbooks. The findings of our study could be used when designing handbooks to enhance their perceived value to students. Further research is needed on the impact of handbooks on learning and increasing students' engagement with handbook content. There are many aspects of handbook content and delivery that could be used to improve students' perceptions regarding handbooks. Handbooks could support students by providing information. © 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

  7. International Fellows of NCI at Frederick | Poster

    Science.gov (United States)

    Each year, the Employee Diversity Team (EDT) acknowledges members of the NCI at Frederick Community for their achievements and contributions towards the mission of facility.  Historically, the team has profiled the “Women of NCI at Frederick,” but this year, the team decided to instead shed light on the diverse and successful individuals who make up the international fellows community.

  8. International Fellows of NCI at Frederick | Poster

    Science.gov (United States)

    Each year, the Employee Diversity Team (EDT) acknowledges members of the NCI at Frederick Community for their achievements and contributions towards the mission of facility.  Historically, the team has profiled the “Women of NCI at Frederick,” but this year, the team decided to instead shed light on the diverse and successful individuals who make up the international fellows community.

  9. Java EE 7 handbook

    CERN Document Server

    Pilgrim, Peter A

    2013-01-01

    Java EE 7 Handbook is an example based tutorial with descriptions and explanations.""Java EE 7 Handbook"" is for the developer, designer, and architect aiming to get acquainted with the Java EE platform in its newest edition. This guide will enhance your knowledge about the Java EE 7 platform. Whether you are a long-term Java EE (J2EE) developer or an intermediate level engineer on the JVM with just Java SE behind you, this handbook is for you, the new contemporary Java EE 7 developer!

  10. Handbook of energy

    CERN Document Server

    Cleveland, Cutler J

    2013-01-01

    Handbook of Energy, Volume II: Chronologies, Top Ten Lists, and Word Clouds draws together a comprehensive account of the energy field from the prestigious and award-winning authors of the Encyclopedia of Energy (2004), The Dictionary of Energy, Expanded Edition (2009), and the Handbook of Energy, Volume I (2013). Handbook of Energy, Volume II takes the wealth of information about historical aspects of energy spread across many books, journals, websites, disciplines, ideologies, and user communities and synthesizes the information in one central repository. This book meets the needs of a di

  11. Asp-52 in combination with Asp-398 plays a critical role in ATP hydrolysis of chaperonin GroEL.

    Science.gov (United States)

    Koike-Takeshita, Ayumi; Mitsuoka, Kaoru; Taguchi, Hideki

    2014-10-24

    The Escherichia coli chaperonin GroEL is a double-ring chaperone that assists protein folding with the aid of GroES and ATP. Asp-398 in GroEL is known as one of the critical residues on ATP hydrolysis because GroEL(D398A) mutant is deficient in ATP hydrolysis (Asp-52 in the corresponding E. coli GroEL, in addition to Asp-398 is also important for ATP hydrolysis. We investigated the role of Asp-52 in GroEL and found that ATPase activity of GroEL(D52A) and GroEL(D52A/D398A) mutants was ∼ 20% and Asp-52 in E. coli GroEL is also involved in the ATP hydrolysis. GroEL(D52A/D398A) formed a symmetric football-shaped GroEL-GroES complex in the presence of ATP, again confirming the importance of the symmetric complex during the GroEL ATPase cycle. Notably, the symmetric complex of GroEL(D52A/D398A) was extremely stable, with a half-time of ∼ 150 h (∼ 6 days), providing a good model to characterize the football-shaped complex. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. [Role of GroEL/GroES chaperonin system and Lon protease in regulation of expression Vibrio fischeri lux genes in Escherichia coli cells].

    Science.gov (United States)

    Manukhov, I V; Kotova, V Iu; Zavil'genskiĭ, G B

    2006-01-01

    It was shown that the chaperonin GroEL/GroES and protease Lon influence the expression of the Vibrio fischeri lux regulon in Escherichia coli cells: E. coli groE mutants bearing hybrid plasmid with the lux regulon were weakly luminescent; cells of the E. coli lon- comprising the entire lux regulon display very intense bioluminescence, with no lag period in the induction curve characteristic of lon+ strains. The luxR gene was cloned from the Vibrio fischeri genome in the pGEX-KG vector. It was shown that the active fusion protein GST-LuxR by affinity chromatography on glutathione-sucrose colony is purified only with proteins GroEL and Lon. The present results showed that the LuxR, transcriptional activator of the V. fischeri lux operon, really complexes with GroEL chaperonin and Lon protease. We suppose, that the GroEL/GroES chaperonin systems is required for the folding of LuxR into an active protein, and the LuxR is the target for the ATP-dependent serine Lon protease of E. coli.

  13. May we eat our fellow creatures?

    DEFF Research Database (Denmark)

    Myskja, B.K.; Gjerris, Mickey

    2016-01-01

    for veganism holds that industrial meat production is by necessity cruel and partaking in it is not virtuous. Diamond agrees that fellow creatures should not be regarded as stages in the production of a meat product but she admits that this attitude to animals as worthy of respect and compassion does...... not necessarily lead to veganism. We suggest that one possible case of virtuous non-veganism is eating domestic animals that lead good lives and are humanely slaughtered. Another could be eating wild animals that could be worse off unless some of them are killed through humane hunting practices...

  14. Risk Characterization Handbook

    Science.gov (United States)

    This Handbook has two parts. The first is the Risk Characterization guidance itself. The second part comprises the Appendices which contain the Risk Characterization Policy, the risk characterization case studies and references.

  15. Water Quality Standards Handbook

    Science.gov (United States)

    The Water Quality Standards Handbook is a compilation of the EPA's water quality standards (WQS) program guidance including recommendations for states, authorized tribes, and territories in reviewing, revising, and implementing WQS.

  16. Utah geothermal institutional handbook

    Energy Technology Data Exchange (ETDEWEB)

    Wagstaff, L.W.; Green, S.

    1982-01-01

    Included in the Handbook are lists of the main permits required and the names of agencies and persons associated with the permits; a summary of pertinent laws, regulations, and permits; and charts outlining typical development and permitting procedures.

  17. The handbook of biomarkers

    CERN Document Server

    Jain, Kewal K

    2010-01-01

    This handbook describes many different types of biomarkers and their discovery. It also presents the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials.

  18. Handbook of antenna technologies

    CERN Document Server

    Liu, Duixian; Nakano, Hisamatsu; Qing, Xianming; Zwick, Thomas

    2016-01-01

    The Handbook of Antenna Technologies aims to present the rapid development of antenna technologies, particularly in the past two decades, and also showcasing the newly developed technologies and the latest applications. The handbook will provide readers with the comprehensive updated reference information covering theory, modeling and optimization methods, design and measurement, new electromagnetic materials, and applications of antennas. The handbook will widely cover not only all key antenna design issues but also fundamentals, issues related to antennas (transmission, propagation, feeding structure, materials, fabrication, measurement, system, and unique design challenges in specific applications). This handbook will benefit the readers as a full and quick technical reference with a high-level historic review of technology, detailed technical descriptions and the latest practical applications.

  19. Newnes electronics assembly handbook

    CERN Document Server

    Brindley, Keith

    2013-01-01

    Newnes Electronics Assembly Handbook: Techniques, Standards and Quality Assurance focuses on the aspects of electronic assembling. The handbook first looks at the printed circuit board (PCB). Base materials, basic mechanical properties, cleaning of assemblies, design, and PCB manufacturing processes are then explained. The text also discusses surface mounted assemblies and packaging of electromechanical assemblies, as well as the soldering process. Requirements for the soldering process; solderability and protective coatings; cleaning of PCBs; and mass solder/component reflow soldering are des

  20. Handbook of Social Capital

    DEFF Research Database (Denmark)

    The Handbook of Social Capital balances the ‘troika' of sociology, political science and economics by offering important contributions to the study of bonding and bridging social capital networks. This inter-disciplinary Handbook intends to serve as a bridge for students and scholars within all...... the social sciences. The contributors explore the different scientific approaches that are all needed if international research is to embrace both the bright and the more shadowy aspects of social capital....

  1. Handbook on Decision Making

    CERN Document Server

    Jain, Lakhmi C

    2010-01-01

    The present "Volume 1: Techniques and Applications" of the "Handbook on Decision Making" presents a useful collection of AI techniques, as well as other complementary methodologies, that are useful for the design and development of intelligent decision support systems. Application examples of how these intelligent decision support systems can be utilized to help tackle a variety of real-world problems in different domains, such as business, management, manufacturing, transportation and food industries, and biomedicine, are presented. The handbook includes twenty condensed c

  2. Rechargeable batteries applications handbook

    CERN Document Server

    1998-01-01

    Represents the first widely available compendium of the information needed by those design professionals responsible for using rechargeable batteries. This handbook introduces the most common forms of rechargeable batteries, including their history, the basic chemistry that governs their operation, and common design approaches. The introduction also exposes reader to common battery design terms and concepts.Two sections of the handbook provide performance information on two principal types of rechargeable batteries commonly found in consumer and industrial products: sealed nickel-cad

  3. DOE handbook electrical safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    Electrical Safety Handbook presents the Department of Energy (DOE) safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety guidance and information for DOE installations to effect a reduction or elimination of risks associated with the use of electrical energy. The objectives of this handbook are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

  4. Energy Handbook; Energy Vademecum

    Energy Technology Data Exchange (ETDEWEB)

    Israels, E.; Stofberg, F.

    2010-05-15

    This is the third and revised print of the Handbook energy-conscious designing of new dwellings. The handbook addresses the latest developments in the field of developing, designing and realizing of new dwellings. [Dutch] Dit is een derde en sterk herziene druk van het 'Vademecum energiebewust ontwerpen van nieuwbouwwoningen', dat in 1992 verscheen. In het 'EnergieVademecum' komen de nieuwste ontwikkelingen op het gebied van energiebewust ontwikkelen, ontwerpen en realiseren van nieuwbouwwoningen aan bod.

  5. Soviet Space Program Handbook.

    Science.gov (United States)

    1988-04-01

    in advance and some events were even broadcast live. Immediately following the first success- ful launch of their new Energia space launch vehicle in...early 1988. Just as a handbook written a couple of years ago would need updating with Mir, Energia , and the SL-16, this handbook will one day need up...1986. Johnson, Nicholas L. The Soviet Year in Space 1983. Colorado Springs, CO: Teledyne Brown Engineering, 1984. Lawton, A. " Energia - Soviet Super

  6. Knowledge Service Engineering Handbook

    CERN Document Server

    Kantola, Jussi

    2012-01-01

    Covering the emerging field of knowledge service engineering, this groundbreaking handbook outlines how to acquire and utilize knowledge in the 21st century. Drawn on the expertise of the founding faculty member of the world's first university knowledge engineering service department, this book describes what knowledge services engineering means and how it is different from service engineering and service production. Presenting multiple cultural aspects including US, Finnish, and Korean, this handbook provides engineering, systemic, industry, and consumer use viewpoints to knowledge service sy

  7. NASA Systems Engineering Handbook

    Science.gov (United States)

    Hirshorn, Steven R.; Voss, Linda D.; Bromley, Linda K.

    2017-01-01

    The update of this handbook continues the methodology of the previous revision: a top-down compatibility with higher level Agency policy and a bottom-up infusion of guidance from the NASA practitioners in the field. This approach provides the opportunity to obtain best practices from across NASA and bridge the information to the established NASA systems engineering processes and to communicate principles of good practice as well as alternative approaches rather than specify a particular way to accomplish a task. The result embodied in this handbook is a top-level implementation approach on the practice of systems engineering unique to NASA. Material used for updating this handbook has been drawn from many sources, including NPRs, Center systems engineering handbooks and processes, other Agency best practices, and external systems engineering textbooks and guides. This handbook consists of six chapters: (1) an introduction, (2) a systems engineering fundamentals discussion, (3) the NASA program project life cycles, (4) systems engineering processes to get from a concept to a design, (5) systems engineering processes to get from a design to a final product, and (6) crosscutting management processes in systems engineering. The chapters are supplemented by appendices that provide outlines, examples, and further information to illustrate topics in the chapters. The handbook makes extensive use of boxes and figures to define, refine, illustrate, and extend concepts in the chapters.

  8. A pharmacogenetics service experience for pharmacy students, residents, and fellows.

    Science.gov (United States)

    Drozda, Katarzyna; Labinov, Yana; Jiang, Ruixuan; Thomas, Margaret R; Wong, Shan S; Patel, Shitalben; Nutescu, Edith A; Cavallari, Larisa H

    2013-10-14

    To utilize a comprehensive, pharmacist-led warfarin pharmacogenetics service to provide pharmacy students, residents, and fellows with clinical and research experiences involving genotype-guided therapy. First-year (P1) through fourth-year (P4) pharmacy students, pharmacy residents, and pharmacy fellows participated in a newly implemented warfarin pharmacogenetics service in a hospital setting. Students, residents, and fellows provided genotype-guided dosing recommendations as part of clinical care, or analyzed samples and data collected from patients on the service for research purposes. Students', residents', and fellows' achievement of learning objectives was assessed using a checklist based on established core competencies in pharmacogenetics. The mean competency score of the students, residents, and fellows who completed a clinical and/or research experience with the service was 97% ±3%. A comprehensive warfarin pharmacogenetics service provided unique experiential and research opportunities for pharmacy students, residents, and fellows and sufficiently addressed a number of core competencies in pharmacogenetics.

  9. NASA Announces 2009 Astronomy and Astrophysics Fellows

    Science.gov (United States)

    2009-02-01

    WASHINGTON -- NASA has selected fellows in three areas of astronomy and astrophysics for its Einstein, Hubble, and Sagan Fellowships. The recipients of this year's post-doctoral fellowships will conduct independent research at institutions around the country. "The new fellows are among the best and brightest young astronomers in the world," said Jon Morse, director of the Astrophysics Division in NASA's Science Mission Directorate in Washington. "They already have contributed significantly to studies of how the universe works, the origin of our cosmos and whether we are alone in the cosmos. The fellowships will serve as a springboard for scientific leadership in the years to come, and as an inspiration for the next generation of students and early career researchers." Each fellowship provides support to the awardees for three years. The fellows may pursue their research at any host university or research center of their choosing in the United States. The new fellows will begin their programs in the fall of 2009. "I cannot tell you how much I am looking forward to spending the next few years conducting research in the U.S., thanks to the fellowships," said Karin Oberg, a graduate student in Leiden, The Netherlands. Oberg will study the evolution of water and ices during star formation when she starts her fellowship at the Smithsonian Astrophysical Observatory in Cambridge, Mass. People Who Read This Also Read... Milky Way's Super-efficient Particle Accelerators Caught in The Act Cosmic Heavyweights in Free-for-all Galaxies Coming of Age in Cosmic Blobs Cassiopeia A Comes Alive Across Time and Space A diverse group of 32 young scientists will work on a wide variety of projects, such as understanding supernova hydrodynamics, radio transients, neutron stars, galaxy clusters and the intercluster medium, supermassive black holes, their mergers and the associated gravitational waves, dark energy, dark matter and the reionization process. Other research topics include

  10. Tannerella forsythia GroEL induces inflammatory bone resorption and synergizes with interleukin-17.

    Science.gov (United States)

    Jung, Y-J; Choi, Y-J; An, S-J; Lee, H-R; Jun, H-K; Choi, B-K

    2016-08-03

    Tannerella forsythia is a major periodontal pathogen, and T. forsythia GroEL is a molecular chaperone homologous to human heat-shock protein 60. Interleukin-17 (IL-17) has been implicated in the pathogenesis of periodontitis and several systemic diseases. This study investigated the potential of T. forsythia GroEL to induce inflammatory bone resorption and examined the cooperative effect of IL-17 and T. forsythia GroEL on inflammatory responses. Human gingival fibroblasts (HGFs) and periodontal ligament (PDL) fibroblasts were stimulated with T. forsythia GroEL and/or IL-17. Gene expression of IL-6, IL-8, and cyclooxygenase-2 (COX-2) and concentrations of IL-6, IL-8, and prostaglandin E2 (PGE2 ) were measured by real-time reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assays, respectively. After stimulation of MG63 cells with T. forsythia GroEL and/or IL-17, gene expression of osteoprotegerin (OPG) was examined. After subcutaneous injection of T. forsythia GroEL and/or IL-17 above the calvaria of BALB/c mice, calvarial bone resorption was assessed by micro-computed tomography and histological examination. Tannerella forsythia GroEL induced IL-6 and IL-8 production in HGFs and PDL cells, and IL-17 further promoted IL-6 and IL-8 production. Both T. forsythia GroEL and IL-17 synergistically increased PGE2 production and inhibited OPG gene expression. Calvarial bone resorption was induced by T. forsythia GroEL injection, and simultaneous injection of T. forsythia GroEL and IL-17 further increased bone resorption. These results suggest that T. forsythia GroEL is a novel virulence factor that can contribute to inflammatory bone resorption caused by T. forsythia and synergizes with IL-17 to exacerbate inflammation and bone resorption.

  11. Characteristics of American Psychological Association Division 40 (clinical neuropsychology) Fellows.

    Science.gov (United States)

    Johnson-Greene, Doug; Collins, K C

    2011-11-01

    Fellow status is an honor bestowed on American Psychological Association (APA) members who have made unusual and outstanding contributions to the field of psychology that have had a national impact. Thus far no studies have examined the characteristics of the individuals who have received this honor. This study examined publicly available data for 157 Division 40 Fellows. Fellows comprise 3.7% of the 4273 members of the division compared to 5.7% of the entire APA membership. Fellows are predominantly male (73%). All but two fellows had earned a Ph.D. with the average time since granting of the doctoral degree of 17.1 ± 6 years (median=16 years) with a range of 7-40 years post-degree. Slightly over half of the fellows hold board certification (53%) in the American Board of Professional Psychology. The largest group of fellows reports their primary employment currently as a university-affiliated medical setting (48%). These data serve to characterize current Division 40 Fellows for the field of neuropsychology and may provide useful information to assist prospective fellow applicants.

  12. Induction of heat shock proteins DnaK, GroEL, and GroES by salt stress in Lactococcus lactis

    DEFF Research Database (Denmark)

    Kilstrup, Mogens; Jacobsen, Susanne; Hammer, Karin

    1997-01-01

    laboratory strain MG1363, which was originally derived from a dairy strain, After two-dimensional separation of proteins, the DnaK, GroEL, and GroES heat shock proteins, the HrcA (Orf1) heat shack repressor, and the glycolytic enzymes pyruvate kinase, glyceral-dehyde-3-phosphate dehydrogenase......, and phosphoglycerate kinase were identified by a combination of Western blotting and direct N-terminal amino acid sequencing of proteins from the gels, Of 400 to 500 visible proteins, 17 were induced more than twofold during heat stress, Two classes of heat stress proteins were identified from their temporal induction...... proteins exhibited a gradual increase in the rate of synthesis after the onset of stress, Unlike other organisms, all salt stress-induced proteins in L. lactis were also subjected to heat stress induction. DnaK, GroEL, and GroES showed similar temporal patterns of induction during salt stress, resembling...

  13. Scientific writing courses for pediatrics fellows.

    Science.gov (United States)

    Cox, B G; Schatz, D A; Van Mierop, L H

    1990-10-01

    A six-week course in scientific writing and publishing was developed for pediatrics fellows at the University of Florida College of Medicine in 1984. It covered three areas: (1) grammar, syntax, and prose style; (2) construction of scientific papers; and (3) the submissions and review process. Increasing enrollment and the requests of course graduates led to the development of a second course, Advanced Scientific Writing; both courses are now offered annually. Class materials consist of texts in scientific writing, comprehensive syllabi, and handouts; the focus is on workshop activities, exercises, collaboration with peers, and individual consultations with the instructor. At the end of each course, participants complete detailed evaluation instruments, and the data obtained are used to modify the course's structure and content the following year.

  14. Fellows as teachers: a model to enhance pediatric resident education

    Directory of Open Access Journals (Sweden)

    Charles V. Smith

    2011-09-01

    Full Text Available Pressures on academic faculty to perform beyond their role as educators has stimulated interest in complementary approaches in resident medical education. While fellows are often believed to detract from resident learning and experience, we describe our preliminary investigations utilizing clinical fellows as a positive force in pediatric resident education. Our objectives were to implement a practical approach to engage fellows in resident education, evaluate the impact of a fellow-led education program on pediatric resident and fellow experience, and investigate if growth of a fellowship program detracts from resident procedural experience.This study was conducted in a neonatal intensive care unit (NICU where fellows designed and implemented an education program consisting of daily didactic teaching sessions before morning clinical rounds. The impact of a fellow-led education program on resident satisfaction with their NICU experience was assessed via anonymous student evaluations. The potential value of the program for participating fellows was also evaluated using an anonymous survey.The online evaluation was completed by 105 residents. Scores were markedly higher after the program was implemented in areas of teaching excellence (4.44 out of 5 versus 4.67, p<0.05 and overall resident learning (3.60 out of 5 versus 4.61, p<0.001. Fellows rated the acquisition of teaching skills and enhanced knowledge of neonatal pathophysiology as the most valuable aspects of their participation in the education program. The anonymous survey revealed that 87.5% of participating residents believed that NICU fellows were very important to their overall training and education.While fellows are often believed to be a detracting factor to residency training, we found that pediatric resident attitudes toward the fellows were generally positive. In our experience, in the specialty of neonatology a fellow-led education program can positively contribute to both

  15. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid

    DEFF Research Database (Denmark)

    Charbon, Godefroid; Wang, Jiangyun; Brustad, Eric

    2011-01-01

    Escherichia coli cells, indicated colocalization with the cell division protein FtsZ at the cleavage furrow, while a second E. coli study of fixed cells indicated more even distribution throughout the cytoplasm. Here, for the first time, we have examined the spatial distribution of GroEL in living cells using......The molecular chaperone GroEL is required for bacterial growth under all conditions, mediating folding assistance, via its central cavity, to a diverse set of cytosolic proteins; yet the subcellular localization of GroEL remains unresolved. An earlier study, using antibody probing of fixed...... incorporation of a fluorescent unnatural amino acid into the chaperone. Fluorescence microscopy indicated that GroEL is diffusely distributed, both under normal and stress conditions. Importantly, the present procedure uses a small, fluorescent unnatural amino acid to visualize GroEL in vivo, avoiding...

  16. Introducing the Newest APPA Fellows: Maggie Kinnaman and Mo Qayoumi

    Science.gov (United States)

    Thaler-Carter, Ruth E.

    2010-01-01

    Few APPA members have contributed as much in as many areas over as many years as the 2010 recipients of APPA's highest individual honor, the APPA Fellow. This article introduces two recipients of the 2010 APPA Fellows, Margaret "Maggie" Kinnaman, who retired as director for business administration for the facilities division at the University of…

  17. Jack Colby Continues Stellar Legacy of APPA Fellows

    Science.gov (United States)

    Thaler-Carter, Ruth E.

    2011-01-01

    This article profiles 2011 APPA Fellow Jack K. Colby, assistant vice chancellor for facilities operations at North Carolina State University. Colby has a history of nonstop service to his profession and to APPA that makes that ever-active, never-stop rabbit look like a piker. Like previous APPA Fellows, Colby could easily rest on his laurels of…

  18. Recruiting post-doctoral fellows into global health research: selecting NIH Fogarty International Clinical Research Fellows.

    Science.gov (United States)

    Heimburger, Douglas C; Warner, Tokesha L; Carothers, Catherine Lem; Blevins, Meridith; Thomas, Yolanda; Gardner, Pierce; Primack, Aron; Vermund, Sten H

    2014-08-01

    From 2008 to 2012, the National Institutes of Health (NIH) Fogarty International Clinical Research Fellows Program (FICRF) provided 1-year mentored research training at low- and middle-income country sites for American and international post-doctoral health professionals. We examined the FICRF applicant pool, proposed research topics, selection process, and characteristics of enrollees to assess trends in global health research interest and factors associated with applicant competitiveness. The majority (58%) of 67 US and 57 international Fellows were women, and 83% of Fellows had medical degrees. Most applicants were in clinical fellowships (41%) or residencies (24%). More applicants proposing infectious disease projects were supported (59%) than applicants proposing non-communicable disease (NCD) projects (41%), although projects that combined both topic areas were most successful (69%). The numbers of applicants proposing research on NCDs and the numbers of these applicants awarded fellowships rose dramatically over time. Funding provided to the FICRF varied significantly among NIH Institutes and Centers and was strongly associated with the research topics awarded. © The American Society of Tropical Medicine and Hygiene.

  19. Springer Handbook of Acoustics

    CERN Document Server

    Rossing, Thomas D

    2007-01-01

    Acoustics, the science of sound, has developed into a broad interdisciplinary field encompassing the academic disciplines of physics, engineering, psychology, speech, audiology, music, architecture, physiology, neuroscience, and others. The Springer Handbook of Acoustics is an unparalleled modern handbook reflecting this richly interdisciplinary nature edited by one of the acknowledged masters in the field, Thomas Rossing. Researchers and students benefit from the comprehensive contents spanning: animal acoustics including infrasound and ultrasound, environmental noise control, music and human speech and singing, physiological and psychological acoustics, architectural acoustics, physical and engineering acoustics, signal processing, medical acoustics, and ocean acoustics. This handbook reviews the most important areas of acoustics, with emphasis on current research. The authors of the various chapters are all experts in their fields. Each chapter is richly illustrated with figures and tables. The latest rese...

  20. Idaho Geothermal Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, Gay Davis; Esposito, Louis; Montgomery, Martin

    1979-07-01

    Idaho's energy problems have increased at alarming rates due to their dependency on imports of gas and oil. The large hydroelectric base developed in Idaho has for years kept the electric rates relatively low and supplied them with energy on a consumer demand basis. However, this resource cannot be 4expected to meet their growing demands in the years to come. Energy alternatives, in whatever form, are extremely important to the future welfare of the State of Idaho. This handbook addresses the implications, uses, requirements and regulations governing one of Idaho's most abundant resources, geothermal energy. The intent of the Idaho Geothermal Handbook is to familiarize the lay person with the basis of geothermal energy in Idaho. The potential for geothermal development in the State of Idaho is tremendous. The authors hope this handbook will both increase your knowledge of geothermal energy and speed you on your way to utilizing this renewable resource.

  1. Springer handbook of robotics

    CERN Document Server

    Khatib, Oussama

    2016-01-01

    The second edition of this handbook provides a state-of-the-art cover view on the various aspects in the rapidly developing field of robotics. Reaching for the human frontier, robotics is vigorously engaged in the growing challenges of new emerging domains. Interacting, exploring, and working with humans, the new generation of robots will increasingly touch people and their lives. The credible prospect of practical robots among humans is the result of the scientific endeavour of a half a century of robotic developments that established robotics as a modern scientific discipline. The ongoing vibrant expansion and strong growth of the field during the last decade has fueled this second edition of the Springer Handbook of Robotics. The first edition of the handbook soon became a landmark in robotics publishing and won the American Association of Publishers PROSE Award for Excellence in Physical Sciences & Mathematics as well as the organization’s Award for Engineering & Technology. The second edition o...

  2. Springer handbook of acoustics

    CERN Document Server

    2014-01-01

    Acoustics, the science of sound, has developed into a broad interdisciplinary field encompassing the academic disciplines of physics, engineering, psychology, speech, audiology, music, architecture, physiology, neuroscience, and electronics. The Springer Handbook of Acoustics is also in his 2nd edition an unparalleled modern handbook reflecting this richly interdisciplinary nature edited by one of the acknowledged masters in the field, Thomas Rossing. Researchers and students benefit from the comprehensive contents. This new edition of the Handbook features over 11 revised and expanded chapters, new illustrations, and 2 new chapters covering microphone arrays  and acoustic emission.  Updated chapters contain the latest research and applications in, e.g. sound propagation in the atmosphere, nonlinear acoustics in fluids, building and concert hall acoustics, signal processing, psychoacoustics, computer music, animal bioacousics, sound intensity, modal acoustics as well as new chapters on microphone arrays an...

  3. Electric power emergency handbook

    Energy Technology Data Exchange (ETDEWEB)

    Labadie, J.R.

    1980-09-01

    The Emergency Electric Power Administration's Emergency Operations Handbook is designed to provide guidance to the EEPA organization. It defines responsibilities and describes actions performed by the government and electric utilities in planning for, and in operations during, national emergencies. The EEPA Handbook is reissued periodically to describe organizational changes, to assign new duties and responsibilities, and to clarify the responsibilities of the government to direct and coordinate the operations of the electric utility industry under emergencies declared by the President. This Handbook is consistent with the assumptions, policies, and procedures contained in the National Plan for Emergency Preparedness. Claimancy and restoration, communications and warning, and effects of nuclear weapons are subjects covered in the appendices.

  4. COMPTEL observations of GRO J1655-40

    Science.gov (United States)

    vanDijk, R.; Bennett, K.; Winkler, C.; Bloemen, H.; Hermsen, W.; Diehl, R.; Schoenfelder, V.; McConnell, M.; Ryan, J.

    1997-01-01

    The transient black hole candidate GRO J1655-40 was shown elsewhere to eject matter at apparently superluminal velocities. The oriented scintillation spectrometer experiment (OSSE) spectra, measured during the X-ray outbursts, are consistent with a single power law up to 600 keV, with no evidence of a high energy cutoff. The detection of the flaring behavior of this source up to 10 MeV was claimed elsewhere. The Compton telescope (COMPTEL) observations in the 0.75 to 30 MeV band of this source are analyzed. The upper limits on the time averaged emission are presented and gamma ray flares are searched for. It is concluded that the COMPTEL data can neither confirm nor refute the claimed detection of a large gamma ray flare from this source. The gamma ray flare search in five years' worth of data did not reveal evidence for the occurrence of strong flares on timescales of two days.

  5. Unilateral Amblyopia Affects Two Eyes: Fellow Eye Deficits in Amblyopia.

    Science.gov (United States)

    Meier, Kimberly; Giaschi, Deborah

    2017-03-01

    Unilateral amblyopia is a visual disorder that arises after selective disruption of visual input to one eye during critical periods of development. In the clinic, amblyopia is understood as poor visual acuity in an eye that was deprived of pattern vision early in life. By its nature, however, amblyopia has an adverse effect on the development of a binocular visual system and the interactions between signals from two eyes. Visual functions aside from visual acuity are impacted, and many studies have indicated compromised sensitivity in the fellow eye even though it demonstrates normal visual acuity. While these fellow eye deficits have been noted, no overarching theory has been proposed to describe why and under what conditions the fellow eye is impacted by amblyopia. Here, we consider four explanations that may account for decreased fellow eye sensitivity: the fellow eye is adversely impacted by treatment for amblyopia; the maturation of the fellow eye is delayed by amblyopia; fellow eye sensitivity is impacted for visual functions that rely on binocular cortex; and fellow eye deficits reflect an adaptive mechanism that works to equalize the sensitivity of the two eyes. To evaluate these ideas, we describe five visual functions that are commonly reported to be deficient in the amblyopic eye (hyperacuity, contrast sensitivity, spatial integration, global motion, and motion-defined form), and unify the current evidence for fellow eye deficits. Further research targeted at exploring fellow eye deficits in amblyopia will provide us with a broader understanding of normal visual development and how amblyopia impacts the developing visual system.

  6. Handbook of optical design

    CERN Document Server

    Malacara-Hernández, Daniel

    2013-01-01

    Handbook of Optical Design, Third Edition covers the fundamental principles of geometric optics and their application to lens design in one volume. It incorporates classic aspects of lens design along with important modern methods, tools, and instruments, including contemporary astronomical telescopes, Gaussian beams, and computer lens design. Written by respected researchers, the book has been extensively classroom-tested and developed in their lens design courses. This well-illustrated handbook clearly and concisely explains the intricacies of optical system design and evaluation. It also di

  7. Electric power distribution handbook

    CERN Document Server

    Short, Thomas Allen

    2003-01-01

    Of the ...big three... components of the electricity infrastructure, distribution typically gets the least attention, and no thorough, up-to-date treatment of the subject has been published in years. Filling that void, the Electric Power Distribution Handbook provides comprehensive information on the electrical aspects of power distribution systems. It is an unparalleled source for the background information, hard-to-find tables, graphs, methods, and statistics that power engineers need, and includes tips and solutions for problem solving and improving performance. In short, this handbook giv

  8. Handbook of surveillance technologies

    CERN Document Server

    Petersen, JK

    2012-01-01

    From officially sanctioned, high-tech operations to budget spy cameras and cell phone video, this updated and expanded edition of a bestselling handbook reflects the rapid and significant growth of the surveillance industry. The Handbook of Surveillance Technologies, Third Edition is the only comprehensive work to chronicle the background and current applications of the full-range of surveillance technologies--offering the latest in surveillance and privacy issues.Cutting-Edge--updates its bestselling predecessor with discussions on social media, GPS circuits in cell phones and PDAs, new GIS s

  9. Handbook of biomedical optics

    CERN Document Server

    Boas, David A

    2011-01-01

    Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques.Organized into six sections, this handbook: Contains intr

  10. Handbook of vacuum physics

    CERN Document Server

    1964-01-01

    Handbook of Vacuum Physics, Volume 3: Technology is a handbook of vacuum physics, with emphasis on the properties of miscellaneous materials such as mica, oils, greases, waxes, and rubber. Accurate modern tables of physical constants, properties of materials, laboratory techniques, and properties of commercial pumps, gauges, and leak detectors are presented. This volume is comprised of 12 chapters and begins with a discussion on pump oils, divided into rotary pump oils and vapor pump oils. The next chapter deals with the properties and applications of greases, including outgassing and vapor pr

  11. Handbook of graph theory

    CERN Document Server

    Gross, Jonathan L

    2003-01-01

    The Handbook of Graph Theory is the most comprehensive single-source guide to graph theory ever published. Best-selling authors Jonathan Gross and Jay Yellen assembled an outstanding team of experts to contribute overviews of more than 50 of the most significant topics in graph theory-including those related to algorithmic and optimization approaches as well as ""pure"" graph theory. They then carefully edited the compilation to produce a unified, authoritative work ideal for ready reference.Designed and edited with non-experts in mind, the Handbook of Graph Theory makes information easy to fi

  12. Nanoelectronic device applications handbook

    CERN Document Server

    Morris, James E

    2013-01-01

    Nanoelectronic Device Applications Handbook gives a comprehensive snapshot of the state of the art in nanodevices for nanoelectronics applications. Combining breadth and depth, the book includes 68 chapters on topics that range from nano-scaled complementary metal-oxide-semiconductor (CMOS) devices through recent developments in nano capacitors and AlGaAs/GaAs devices. The contributors are world-renowned experts from academia and industry from around the globe. The handbook explores current research into potentially disruptive technologies for a post-CMOS world.These include: Nanoscale advance

  13. The digital media handbook

    CERN Document Server

    Dewdney, Andrew

    2013-01-01

    The new edition of The Digital Media Handbook presents an essential guide to the historical and theoretical development of digital media, emphasising cultural continuity alongside technological change, and highlighting the emergence of new forms of communication in contemporary networked culture.Andrew Dewdney and Peter Ride present detailed critical commentary and descriptive historical accounts, as well as a series of interviews from a range of digital media practitioners, including producers, developers, curators and artists.The Digital Media Handbook highlights key concerns of today's prac

  14. Information security management handbook

    CERN Document Server

    2002-01-01

    The Information Security Management Handbook continues its tradition of consistently communicating the fundamental concepts of security needed to be a true CISSP. In response to new developments, Volume 4 supplements the previous volumes with new information covering topics such as wireless, HIPAA, the latest hacker attacks and defenses, intrusion detection, and provides expanded coverage on security management issues and applications security. Even those that don't plan on sitting for the CISSP exam will find that this handbook is a great information security reference.The changes in the tech

  15. Practical electronics handbook

    CERN Document Server

    Sinclair, Ian R

    1988-01-01

    Practical Electronics Handbook, Second Edition covers information useful in electronics, with focus on mathematical conventions. The handbook discusses the passive (resistors, capacitors, band coding, and inductors) and active discrete (diodes, transistors and negative feedback) components; discrete component circuits; and transferring digital data. Linear I.C.s, which are the single-chip arrangements of amplifier circuits that are intended to be biased and operated in a linear way, and digital I.C.s, which process signals and consist of two significant voltage levels, are also considered. T

  16. Information security management handbook

    CERN Document Server

    Tipton, Harold F

    2003-01-01

    Since 1993, the Information Security Management Handbook has served not only as an everyday reference for information security practitioners but also as an important document for conducting the intense review necessary to prepare for the Certified Information System Security Professional (CISSP) examination. Now completely revised and updated and in its fifth edition, the handbook maps the ten domains of the Information Security Common Body of Knowledge and provides a complete understanding of all the items in it. This is a ...must have... book, both for preparing for the CISSP exam and as a c

  17. Handbook of finite fields

    CERN Document Server

    Mullen, Gary L

    2013-01-01

    Poised to become the leading reference in the field, the Handbook of Finite Fields is exclusively devoted to the theory and applications of finite fields. More than 80 international contributors compile state-of-the-art research in this definitive handbook. Edited by two renowned researchers, the book uses a uniform style and format throughout and each chapter is self contained and peer reviewed. The first part of the book traces the history of finite fields through the eighteenth and nineteenth centuries. The second part presents theoretical properties of finite fields, covering polynomials,

  18. Handbook of probability

    CERN Document Server

    Florescu, Ionut

    2013-01-01

    THE COMPLETE COLLECTION NECESSARY FOR A CONCRETE UNDERSTANDING OF PROBABILITY Written in a clear, accessible, and comprehensive manner, the Handbook of Probability presents the fundamentals of probability with an emphasis on the balance of theory, application, and methodology. Utilizing basic examples throughout, the handbook expertly transitions between concepts and practice to allow readers an inclusive introduction to the field of probability. The book provides a useful format with self-contained chapters, allowing the reader easy and quick reference. Each chapter includes an introductio

  19. Software quality assurance handbook

    Energy Technology Data Exchange (ETDEWEB)

    1990-09-01

    There are two important reasons for Software Quality Assurance (SQA) at Allied-Signal Inc., Kansas City Division (KCD): First, the benefits from SQA make good business sense. Second, the Department of Energy has requested SQA. This handbook is one of the first steps in a plant-wide implementation of Software Quality Assurance at KCD. The handbook has two main purposes. The first is to provide information that you will need to perform software quality assurance activities. The second is to provide a common thread to unify the approach to SQA at KCD. 2 figs.

  20. Where Are They Now? A Survey of Woodrow Wilson Fellows and Woodrow Wilson Dissertation Fellows Elected Between 1945 and 1971.

    Science.gov (United States)

    Woodrow Wilson National Fellowship Foundation, Princeton, NJ.

    Woodrow Wilson Fellows and Dissertation Fellows elected between 1945 and 1971 were surveyed to trace their educational careers, judge the effectiveness of the selection process, and determine what they are now doing with their education. Some elements covered by other national studies were included to make possible a comparison of the Woodrow…

  1. Probing the functional mechanism of Escherichia coli GroEL using circular permutation.

    Directory of Open Access Journals (Sweden)

    Tomohiro Mizobata

    Full Text Available BACKGROUND: The Escherichia coli chaperonin GroEL subunit consists of three domains linked via two hinge regions, and each domain is responsible for a specific role in the functional mechanism. Here, we have used circular permutation to study the structural and functional characteristics of the GroEL subunit. METHODOLOGY/PRINCIPAL FINDINGS: Three soluble, partially active mutants with polypeptide ends relocated into various positions of the apical domain of GroEL were isolated and studied. The basic functional hallmarks of GroEL (ATPase and chaperoning activities were retained in all three mutants. Certain functional characteristics, such as basal ATPase activity and ATPase inhibition by the cochaperonin GroES, differed in the mutants while at the same time, the ability to facilitate the refolding of rhodanese was roughly equal. Stopped-flow fluorescence experiments using a fluorescent variant of the circularly permuted GroEL CP376 revealed that a specific kinetic transition that reflects movements of the apical domain was missing in this mutant. This mutant also displayed several characteristics that suggested that the apical domains were behaving in an uncoordinated fashion. CONCLUSIONS/SIGNIFICANCE: The loss of apical domain coordination and a concomitant decrease in functional ability highlights the importance of certain conformational signals that are relayed through domain interlinks in GroEL. We propose that circular permutation is a very versatile tool to probe chaperonin structure and function.

  2. The Asphalt Handbook.

    Science.gov (United States)

    Asphalt Inst., College Park, MD.

    The new and completely revised edition of the Asphalt Handbook, a standard reference work in the field of asphalt technology and construction, summarizes with reference the information contained in other Asphalt Institute technical manuals. Major areas discussed include the following--(1) uses of asphalt, (2) terms relating to asphalt and its…

  3. Rain Gauges Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Bartholomew, M. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-01-01

    To improve the quantitative description of precipitation processes in climate models, the Atmospheric Radiation Measurement (ARM) Climate Research Facility deployed rain gauges located near disdrometers (DISD and VDIS data streams). This handbook deals specifically with the rain gauges that make the observations for the RAIN data stream. Other precipitation observations are made by the surface meteorology instrument suite (i.e., MET data stream).

  4. Area Handbook for Syria.

    Science.gov (United States)

    Nyrop, Richard; And Others

    This volume on Syria is one of a series of handbooks prepared by the Foreign Area Studies (FAS) of the American University, designed to be useful to military and other personnel who need a convenient compilation of basic facts about the social, economic, political, and military institutions and practices of various countries. The emphasis is on…

  5. Area Handbook for Burma.

    Science.gov (United States)

    Henderson, John W.; And Others

    This volume, one of a series of handbooks on foreign culture, is intended as a reference tool for military and other personnel requiring an objective, comprehensive, and balanced description of Burma's modern society. An analytical appraisal of social, economic, and political aspects is provided with emphasis on the interaction of these societal…

  6. Toy Demonstrator's "VISIT" Handbook.

    Science.gov (United States)

    Levenstein, Phyllis

    The role of the toy demonstrator in a home-based, mother-involved intervention effort (Verbal Interaction Project) is presented in this handbook for staff members. It is believed that the prerequisites for functioning in the toy demonstrator's role are a sense of responsibility, patience with the children and their mothers, and willingness to be…

  7. Radiation`96. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The conference program includes eight invited lectures which cover a range of contemporary topics in radiation science and technology. In addition, thirty-two oral papers were presented, along with forty-five posters. The conference handbook contains one-page precis or extended abstracts of all presentations, and is a substantial compendium of current radiation research in Australia.

  8. APA Educational Psychology Handbook

    Science.gov (United States)

    Harris, Karen R., Ed.; Graham, Steve, Ed.; Urdan, Tim, Ed.

    2011-01-01

    The "APA Educational Psychology Handbook" reflects the broad nature of the field today, with state-of-the-science reviews of the diverse critical theories driving research and practice; in-depth investigation of the range of individual differences and cultural/contextual factors that affect student achievement, motivation, and beliefs;…

  9. Basic Spanish: Student Handbook.

    Science.gov (United States)

    Hartley, Peggy J.; And Others

    This handbook was first planned for use by the teacher and students of two experimental introductory Spanish classes of the University of South Carolina, employing the materials "Espanol a lo vivo" during the 1971-72 and 1972-73 academic years. One group followed a traditional approach to instruction having class four times weekly, while the other…

  10. Animal damage management handbook.

    Science.gov (United States)

    Hugh C. Black

    1994-01-01

    This handbook treats animal damage management (ADM) in the West in relation to forest, range, and recreation resources; predator management is not addressed. It provides a comprehensive reference of safe, effective, and practical methods for managing animal damage on National Forest System lands. Supporting information is included in references after each chapter and...

  11. The Military Instructor's Handbook

    DEFF Research Database (Denmark)

    Sjøstedt, Peter; Grønlund, Thomas

    The Military Instructor's handbook was written for the basic professional training of instructors in the danish defence. The book describes the work of instructors and their areas of responsibility, and it offers guidance and direction on how to plan, conduct and evaluate learning activities...

  12. Child Care Services Handbook.

    Science.gov (United States)

    Duval County School Board, Jacksonville, FL.

    A companion document to the curriculum guide for a secondary level child care services curriculum, this handbook contains a variety of administrative and program resources for the teacher: The vocational curriculum outline for child care services; a calendar of suggested public relations activities; procedures for building child care services…

  13. Area Handbook for Mozambique.

    Science.gov (United States)

    Herrick, Allison Butler

    This publication is one of a series of handbooks prepared by the Foreign Areas Studies (FAS) of The American University, designed to be useful to military and other personnel who need a convenient compilation of basic facts about the social, economic, political and military institutions and practices of various countries. The present handbook…

  14. Handbook on Peace Education.

    Science.gov (United States)

    Wulf, Christoph, Ed.

    The intention of this handbook is to report on the present situation in the international discussion on peace education and to make further development of this field possible in the peace movement. The first of the three sections contains papers which are contributions on preconditions for and the foundations of peace education, along with…

  15. Connecticut Marketing Education Handbook.

    Science.gov (United States)

    West Haven Board of Education, CT.

    This revised marketing education handbook is intended to assist marketing education teachers and administrators in Connecticut in preparing students to enter meaningful careers in marketing, merchandising, and management positions. The 17 units of this reference guide cover the following topics: introduction; mission and scope of marketing…

  16. Handbook on Peace Education

    Science.gov (United States)

    Salomon, Gavriel, Ed.; Cairns, Ed, Ed.

    2009-01-01

    This handbook encompasses a range of disciplines that underlie the field of peace education and provides the rationales for the ways it is actually carried out. The discipline is a composite of contributions from a variety of disciplines ranging from social psychology to philosophy and from communication to political science. That is, peace…

  17. The Population Activist's Handbook.

    Science.gov (United States)

    Population Inst., Washington, DC.

    This handbook is a guide to effective action strategies on dealing with overpopulation. Divided into five sections, the book outlines programs, suggests references, and lists resources that are helpful for thinking and for planning action on population issues. Section one focuses on strategies to change the current population policy choices made…

  18. The Population Activist's Handbook.

    Science.gov (United States)

    Population Inst., Washington, DC.

    This handbook is a guide to effective action strategies on dealing with overpopulation. Divided into five sections, the book outlines programs, suggests references, and lists resources that are helpful for thinking and for planning action on population issues. Section one focuses on strategies to change the current population policy choices made…

  19. European food law handbook

    NARCIS (Netherlands)

    Meulen, van der B.M.J.; Velde, van der M.; Szajkowska, A.; Verbruggen, R.

    2008-01-01

    This handbook analyses and explains the institutional, substantive and procedural elements of EU food law, taking the General Food Law as a focus point. Principles are discussed as well as specific rules addressing food as a product, the processes related to food and communication about food through

  20. Area Handbook for Uruguay.

    Science.gov (United States)

    Weil, Thomas E.; And Others

    This volume is one of 62 in a series of handbooks designed to be useful to military and other personnel who need a convenient compilation of basic facts about the social, economic, political, and military institutions and practices of various countries. The emphasis is on objective description of the nation's present society and the kinds of…

  1. Library Media Services Handbook.

    Science.gov (United States)

    Winnipeg School Div. Number 1, Manitoba (Canada).

    This 1991 edition of the handbook for Winnipeg School Division Number 1 school library media programs presents detailed program guidelines, objectives, philosophies, and goals in five major sections: (1) Library Policy and Practices (statement of the division's educational philosophy and goals, philosophy and goals of the division's library…

  2. DOE handbook: Design considerations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-01

    The Design Considerations Handbook includes information and suggestions for the design of systems typical to nuclear facilities, information specific to various types of special facilities, and information useful to various design disciplines. The handbook is presented in two parts. Part 1, which addresses design considerations, includes two sections. The first addresses the design of systems typically used in nuclear facilities to control radiation or radioactive materials. Specifically, this part addresses the design of confinement systems and radiation protection and effluent monitoring systems. The second section of Part 1 addresses the design of special facilities (i.e., specific types of nonreactor nuclear facilities). The specific design considerations provided in this section were developed from review of DOE 6430.1A and are supplemented with specific suggestions and considerations from designers with experience designing and operating such facilities. Part 2 of the Design Considerations Handbook describes good practices and design principles that should be considered in specific design disciplines, such as mechanical systems and electrical systems. These good practices are based on specific experiences in the design of nuclear facilities by design engineers with related experience. This part of the Design Considerations Handbook contains five sections, each of which applies to a particular engineering discipline.

  3. Rockin' Readers Coordinator Handbook.

    Science.gov (United States)

    Alachua County Schools, Gainesville, FL.

    This coordinator's handbook describes the "Rockin' Readers" program, in which senior-citizen volunteers are matched with specifically targeted at-risk children (usually of kindergarten age or slightly older) in Alachua County, Florida, who tested below their peer group in language development and reading readiness skills. The handbook…

  4. APA Educational Psychology Handbook

    Science.gov (United States)

    Harris, Karen R., Ed.; Graham, Steve, Ed.; Urdan, Tim, Ed.

    2011-01-01

    The "APA Educational Psychology Handbook" reflects the broad nature of the field today, with state-of-the-science reviews of the diverse critical theories driving research and practice; in-depth investigation of the range of individual differences and cultural/contextual factors that affect student achievement, motivation, and beliefs; and close…

  5. Nuclear safeguards technology handbook

    Energy Technology Data Exchange (ETDEWEB)

    1977-12-01

    The purpose of this handbook is to present to United States industrial organizations the Department of Energy's (DOE) Safeguards Technology Program. The roles and missions for safeguards in the U.S. government and application of the DOE technology program to industry safeguards planning are discussed. A guide to sources and products is included. (LK)

  6. Handbook of web surveys

    NARCIS (Netherlands)

    Bethlehem, J.; Biffignandi, S.

    2012-01-01

    Best practices to create and implementhighly effective web surveys Exclusively combining design and sampling issues, Handbook of Web Surveys presents a theoretical yet practical approach to creating and conducting web surveys. From the history of web surveys to various modes of data collection to ti

  7. Handbook of Agricultural Geophysics

    Science.gov (United States)

    Geophysical methods continue to show great promise for use in agriculture. The term “agricultural geophysics” denotes a subdiscipline of geophysics that is focused only on agricultural applications. The Handbook of Agricultural Geophysics was compiled to include a comprehensive overview of the geoph...

  8. Handbook of Plant Virology

    NARCIS (Netherlands)

    Khan, J.A.; Dijkstra, J.

    2006-01-01

    The Handbook of Plant Virology is a comprehensive guide to the terms and expressions commonly used in the study of plant virology, complete with descriptions of plant virus families down to the generic level. Rather than simply listing terms in alphabetical order, this unique book links each term to

  9. Handbook of nanomaterials properties

    CERN Document Server

    Luo, Dan; Schricker, Scott R; Sigmund, Wolfgang; Zauscher, Stefan

    2014-01-01

    Nanomaterials attract tremendous attention in recent researches. Although extensive research has been done in this field it still lacks a comprehensive reference work that presents data on properties of different Nanomaterials. This Handbook of Nanomaterials Properties will be the first single reference work that brings together the various properties with wide breadth and scope.

  10. Handbook of Moral Development

    Science.gov (United States)

    Killen, Melanie; Smetana, Judith

    2006-01-01

    The psychological study of moral development has expanded greatly, both in terms of the diversity of theoretical perspectives that are represented in the field, as well as in the range of topics that have been studied. This "Handbook of Moral Development" represents the diversity and multidisciplinary influences on current theorizing about the…

  11. Handbook for Learning Centers.

    Science.gov (United States)

    Norwalk Board of Education, CT.

    The handbook for learning centers contains guidelines, forms, and supplementary information to be used with all children identified as having a learning disability, mild retardation, or sensory deprivation in the Norwalk, Connecticut public schools. It is stressed that the learning center should provide supportive services for at least 35 minutes…

  12. Preface Learning Design Handbook

    NARCIS (Netherlands)

    Koper, Rob; Tattersall, Colin; (eds)

    2005-01-01

    Provided as full text at Springer Online (also here). Koper, R. & Tattersall, C. (2005). Preface. In: Koper, R. & Tattersall, C., Learning Design: A Handbook on Modelling and Delivering Networked Education and Training (pp. 3-20). Berlin-Heidelberg: Springer Verlag.

  13. APA Educational Psychology Handbook

    Science.gov (United States)

    Harris, Karen R., Ed.; Graham, Steve, Ed.; Urdan, Tim, Ed.

    2011-01-01

    The "APA Educational Psychology Handbook" reflects the broad nature of the field today, with state-of-the-science reviews of the diverse critical theories driving research and practice; in-depth investigation of the range of individual differences and cultural/contextual factors that affect student achievement, motivation, and beliefs;…

  14. Single-step Purification of Molecular Chaperone GroEL by Expanded Bed Chromatography

    Institute of Scientific and Technical Information of China (English)

    佟晓冬; 杨征; 董晓燕; 孙彦

    2003-01-01

    Expanded bed adsorption (EBA) is an integrative downstream processing technique for the purification of biological substances directly from unclarified feedstock. In this study, molecular chaperone GroEL, an important protein folding helper both in vivo and in vitro, was purified by the single-step EBA technique from the unclarified homogenate of recombinant E. coli cells. Compared with packed bed adsorption, the EBA technique provided a single-step approach to yield an electrophoretic purity of GroEL. After the homogenate loading and column washing in the expanded bed mode, the GroEL protein was recovered by stepwise salt-gradient elution in packed-bed or expanded-bed modes, respectively. The expanded-bed elution mode was found as efficient as the packed-bed mode in the purification of GroEL from cell disruptate.

  15. Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression

    DEFF Research Database (Denmark)

    Laing, Adam F; Lowell, Sally; Brickman, Joshua M

    2015-01-01

    Gro/TLE proteins (TLE1-4) are a family of transcriptional corepressors acting downstream of multiple signalling pathways. Several TLEs are expressed in a dynamic manner throughout embryonic development and at high levels in embryonic stem cells (ESCs). Here we find that Gro/TLE is not required...... in ESC for sustaining pluripotency and suppressing differentiation genes, but rather is important for the shutting down of the pluripotency network in differentiation. Consistent with this view, we found that one of the Gro/TLE family, TLE4 is expressed heterogeneously in ESCs in a population...... that corresponds to a Nanog low subset of ESC culture. TLE4 expression is also increased in response to LIF withdrawal and Fgf/Mek/Erk stimulation. To explore the role of Gro/TLE in more detail we generated an allelic series of knockout ESCs of two TLE genes expressed most dynamically in early differentiation, TLE...

  16. National Academy of Engineering selects Engineering Education Fellows

    OpenAIRE

    Elliott, Jean

    2004-01-01

    Gary Downey, of Blacksburg, professor of science and technology in society in the College of Liberal Arts and Human Sciences at Virginia Tech, has been named a Boeing Company Engineering Education Senior Fellow by the National Academy of Engineering (NAE).

  17. John Brozovsky appointed Wayne E. Leininger Junior Faculty Fellow

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    John Brozovsky, associate professor of accounting and information systems in the Pamplin College of Business at Virginia Tech, has been appointed the Wayne E. Leininger Junior Faculty Fellow by the Virginia Tech Board of Visitors.

  18. Woodrow Wilson Fellows--Who Are They Now?

    Science.gov (United States)

    Rein, Richard K.

    1975-01-01

    The Woodrow Wilson Senior Fellows are prominent leaders in business and government that are sent to college campuses for a week instead of a one-night lecture. This program has proved to be immensely popular on campuses. (PG)

  19. The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements

    Science.gov (United States)

    Bhat, Aadil H.; Pathak, Deepika; Rao, Alka

    2017-01-01

    Threonylcarbamoyladenosine is a universally conserved essential modification of tRNA that ensures translational fidelity in cellular milieu. TsaD, TsaB and TsaE are identified as tRNA-A37-threonylcarbamoyl (t6A)-transferase enzymes that have been reconstituted in vitro, in few bacteria recently. However, transcriptional organization and regulation of these genes are not known in any of these organisms. This study describes the intricate architecture of a complex multicistronic alr-groEL1 operon, harboring essential genes, namely tsaD, tsaB, tsaE, groES, groEL1, and alr (required for cell wall synthesis), and rimI encoding an N-α- acetyltransferase in Mycobacterium tuberculosis. Using northern blotting, RT-PCR and in vivo fluorescence assays, genes alr to groEL1 were found to constitute an ~6.3 kb heptacistronic operon with multiple internal promoters and an I-shaped intrinsic hairpin-like cis-regulatory element. A strong promoter PtsaD within the coding sequence of rimI gene is identified in M. tuberculosis, in addition. The study further proposes an amendment in the known bicistronic groESL1 operon annotation by providing evidence that groESL1 is co-transcribed as sub-operon of alr-groEL1 operon. The architecture of alr-groEL1 operon, conservation of the genetic context and a mosaic transcriptional profile displayed under various stress conditions convincingly suggest the involvement of this operon in stress adaptation in M. tuberculosis. PMID:28256563

  20. Systematic Reviews and Meta-analyses for Cardiology Fellows.

    Science.gov (United States)

    Fares, Munes; Alahdab, Fares; Alsaied, Tarek

    2016-07-01

    Participating in a scholarly activity is one of the training requirements for cardiology fellows. However, it can be very challenging to complete a research project during such a busy period of clinical training. To help the cardiology fellows in choosing and starting off a research project, a light has been shed on the process of conducting a systematic review, and the importance of this research activity, as well as its limitations. © 2016 Wiley Periodicals, Inc.

  1. Clon of GroEL gene and construction of eukaryotic expression vector in myobacterium tuberclosis%结核分枝杆菌GroEL基因的克隆及真核表达质粒的构建

    Institute of Scientific and Technical Information of China (English)

    付风云; 张卫英

    2009-01-01

    目的 克隆结核分枝杆菌基因组携带的两组GroEL基因,即GroEL1和GroEL2,它们分别编码热休克蛋白HSP60(cpn60.1)和HSP65(cpn60.2),并构建真核表达质粒.方法 用带有EcoR I和Xba I酶切位点的特异性引物,从结核杆菌H37Rv株中PCR扩增两组GroEL基因,构建重组真核表达质粒pCDNA3.1-GroEL1和pCDNA3.1-GroEL2,并进行酶切和测序鉴定.结果 成功克隆了结核分枝杆菌两组GroEL基因,酶切鉴定pCDNA3.1-GroEL1和pCDNA3.1-GroEL2构建成功,经DNA测序证实,载体上插入的序列与GenBank公布的序列一致.结论 获得了结核分枝杆菌GroEL1和GroEL2基因,成功地构建了含GroEL1和GroEL2基因的真核表达质粒,为研究其作为核酸疫苗在免疫学方面作用提供材料.

  2. BeppoSAX observations of GRO J1744-28

    CERN Document Server

    Doroshenko, R; Doroshenko, V; Suleimanov, V; Piraino, S

    2015-01-01

    We present an analysis of BeppoSAX observations of the unique transient bursting X-ray pulsar GRO J1744-28. The observations took place in March 1997 during the decay phase of the outburst. We find that the persistent broadband X-ray continuum of the source is consistent with a cutoff power law typical for the accreting pulsars. We also detect the fluorescence iron line at 6.7 keV and an absorption feature at ~4.5 keV, which we interpret as a cyclotron line. The corresponding magnetic field strength in the line forming region is ~3.7 x 10^11 G. Neither line is detected in the spectra of the bursts. However, additional soft thermal component with kT ~2 keV was required to describe the burst spectrum. We briefly discuss the nature of this component and argue that among other possibilities it might be connected with thermonuclear flashes at the neutron star surface which accompany the accretion-powered bursts in the source.

  3. Double Fellowships in Radiology: A Survey of 2014 Graduating Fellows.

    Science.gov (United States)

    Wong, Thomas Y; Moriarity, Andrew; Lall, Neil; Hoffmann, Jason C; Katz, Douglas S; Flug, Jonathan A

    Radiology fellowship training has evolved from being an uncommon option to being a near requisite for post-training employment in the United States. A subset of fellows elect to pursue second fellowships with potentially substantial implications on both the private sector and academic radiology workforce. The purpose of this study was to assess the proportion of current radiology fellows pursuing multiple years of post-residency fellowship training. After obtaining IRB approval, an anonymous web-based survey was emailed to 1,269 radiology fellows listed as "completing fellowship" in the American College of Radiology database in June 2014. Questions were asked regarding current fellowship training, post-fellowship employment plans, and individual experience pursuing employment. Results were analyzed using the survey analytical software. There were 219 responses received, representing a 17.3% response rate. Ten-percent of respondents were currently completing their second radiology fellowship. Of those completing their first year of fellowship training, 11% indicated plans to complete a second radiology fellowship. This survey provides a snapshot of the percentage of radiology trainees who pursue a second year of fellowship training, currently in the range of 10%. Pursuing a second radiology fellowship may represent a safety net to a substantial subset of fellows who are not able to obtain satisfactory employment following training. Academic programs who rely heavily on fellows should be aware of the proportion of fellows pursuing two fellowships and should be prepared to adapt should this change over time. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Do Pediatric Hematology/Oncology (PHO) Fellows Receive Communication Training?

    Science.gov (United States)

    File, Wilson; Bylund, Carma L.; Kesselheim, Jennifer; Leonard, David; Leavey, Patrick

    2017-01-01

    Purpose The Accreditation Council for Graduate Medical Education (ACGME) has established communication as a core competency for physicians in training. However, data suggest that most pediatric residents perceive inadequate training in the delivery of bad news and the majority of former trainees in pediatric oncology received no formal training in the delivery of bad news during fellowship. The study examines communication training in ACGME accredited US pediatric hematology-oncology (PHO) fellowship programs. Methods An online survey was distributed to 315 PHO fellows in training via the American Society of Pediatric Hematology/Oncology (ASPHO) fellow email registry. Each fellow received an initial request to participate and 2 reminders, while participation was encouraged through a random incentive drawing. Results One hundred and ten fellows (35%) responded. Eighty percent of respondents perceived communication training to be important to fellow education, however only 32% reported receiving communication training (other than direct observation). The most common reported teaching method of fellowship communication training was formal lecture (42%). Twenty-three percent of respondents reported neither communication training nor frequent feedback on their communication skills from faculty observation. This same group was the least satisfied with their programs’ approach to teaching communication (P communication training in PHO fellowships despite ACGME requirements and fellows’ interest in this training. Didactic learning remains the most frequently described training method, yet educational theory identifies the limitation of didactic lectures alone. Communication training employing novel teaching methods and emphasizing communication challenges identified by fellows should be developed and evaluated. PMID:24039096

  5. Geritalk: communication skills training for geriatric and palliative medicine fellows.

    Science.gov (United States)

    Kelley, Amy S; Back, Anthony L; Arnold, Robert M; Goldberg, Gabrielle R; Lim, Betty B; Litrivis, Evgenia; Smith, Cardinale B; O'Neill, Lynn B

    2012-02-01

    Expert communication is essential to high-quality care for older patients with serious illness. Although the importance of communication skills is widely recognized, formal curricula for teaching communication skills to geriatric and palliative medicine fellows is often inadequate or unavailable. The current study drew upon the educational principles and format of an evidence-based, interactive teaching method to develop an intensive communication skills training course designed specifically to address the common communication challenges that geriatric and palliative medicine fellows face. The 2-day retreat, held away from the hospital environment, included large-group overview presentations, small-group communication skills practice, and development of future skills practice commitment. Faculty received in-depth training in small-group facilitation techniques before the course. Geriatric and palliative medicine fellows were recruited to participate in the course and 100% (n = 18) enrolled. Overall satisfaction with the course was very high (mean 4.8 on a 5-point scale). After the course, fellows reported an increase in self-assessed preparedness for specific communication challenges (mean increase 1.4 on 5-point scale, P skills practice (mean 4.3 on 5-point scale). In sum, the intensive communication skills program, customized for the specific needs of geriatric and palliative medicine fellows, improved fellows' self-assessed preparedness for challenging communication tasks and provided a model for ongoing deliberate practice of communication skills.

  6. Mauritanian Arabic. Teacher's Handbook. Peace Corps Language Handbook Series.

    Science.gov (United States)

    Clark, Raymond C.; And Others

    The teaching guide is designed to accompany a set of instructional materials in Mauritanian Arabic (Hassaniya) for Peace Corps volunteers. It provides information and techniques for language teaching in three volumes: (1) a literacy handbook--a volume of lessons on the Arabic alphabet and script; (2) a communication and culture handbook; and (3) a…

  7. 76 FR 60474 - Commercial Item Handbook

    Science.gov (United States)

    2011-09-29

    ... Defense Acquisition Regulations System Commercial Item Handbook AGENCY: Defense Acquisition Regulations... Commercial Item Handbook. The purpose of the Handbook is to help acquisition personnel develop sound business... the Handbook. DATES: Comments should be submitted in writing to the address shown below on or before...

  8. Review of Handbook of New Age

    DEFF Research Database (Denmark)

    Davidsen, Markus Altena

    2011-01-01

    Review of Daren Kemp & James R. Lewis (eds.), Handbook of New Age, in the series Brill Handbooks on Contemporary Religion 1, 2007, Leiden & Boston: Brill.......Review of Daren Kemp & James R. Lewis (eds.), Handbook of New Age, in the series Brill Handbooks on Contemporary Religion 1, 2007, Leiden & Boston: Brill....

  9. The data analysis handbook

    CERN Document Server

    Frank, IE

    1994-01-01

    Analyzing observed or measured data is an important step in applied sciences. The recent increase in computer capacity has resulted in a revolution both in data collection and data analysis. An increasing number of scientists, researchers and students are venturing into statistical data analysis; hence the need for more guidance in this field, which was previously dominated mainly by statisticians. This handbook fills the gap in the range of textbooks on data analysis. Written in a dictionary format, it will serve as a comprehensive reference book in a rapidly growing field. However, this book is more structured than an ordinary dictionary, where each entry is a separate, self-contained entity. The authors provide not only definitions and short descriptions, but also offer an overview of the different topics. Therefore, the handbook can also be used as a companion to textbooks for undergraduate or graduate courses. 1700 entries are given in alphabetical order grouped into 20 topics and each topic is organized...

  10. Handbook of sustainable engineering

    CERN Document Server

    Lee, Kun-Mo

    2013-01-01

    "The efficient utilization of energy, sustainable use of natural resources, and large-scale adoption of sustainable technologies is the key to a sustainable future. The Handbook of Sustainable Engineering provides tools that will help us achieve these goals". Nobel Prize Winner Dr. R.K. Pauchauri, Chairman, UN Intergovernmental Panel on Climate Change As global society confronts the challenges of diminishing resources, ecological degradation, and climate change, engineers play a crucial role designing and building technologies and products that fulfil our needs for utility and sustainability. The Handbook of Sustainable Engineering equips readers with the context and the best practices derived from both academic research and practical examples of successful implementations of sustainable technical solutions. The handbook’s content revolves around the two themes, new ways of thinking and new business models, including sustainable production, products, service systems and consumption while addressing key asse...

  11. Handbook of Practical Astronomy

    CERN Document Server

    Roth, Günter D

    2009-01-01

    With amateurs, students, and teachers of astronomy in high schools and colleges particularly in mind, the Handbook of Practical Astronomy is an essential source to demonstrate trends and variety of astronomical observations. The book presents the substance of celestial bodies for the amateur observer: the planets, the stars, and the galaxies. The sun is the local link to the other stars, the nexus of cosmic evolution. The solar system is made up by the sun and all the celestial bodies orbit it. This system is of special interest for the observing amateur. The Handbook of Practial Astronomy spans astronomy, education and computing. Like many other fields of science, astronomy has become digitized and data rich in recent years. Besides the references at the end of each chapter, there are the notes in the margins with astronomical news and observing highlights on the web.

  12. Handbook of Brain Connectivity

    CERN Document Server

    Jirsa, Viktor K

    2007-01-01

    Our contemporary understanding of brain function is deeply rooted in the ideas of the nonlinear dynamics of distributed networks. Cognition and motor coordination seem to arise from the interactions of local neuronal networks, which themselves are connected in large scales across the entire brain. The spatial architectures between various scales inevitably influence the dynamics of the brain and thereby its function. But how can we integrate brain connectivity amongst these structural and functional domains? Our Handbook provides an account of the current knowledge on the measurement, analysis and theory of the anatomical and functional connectivity of the brain. All contributors are leading experts in various fields concerning structural and functional brain connectivity. In the first part of the Handbook, the chapters focus on an introduction and discussion of the principles underlying connected neural systems. The second part introduces the currently available non-invasive technologies for measuring struct...

  13. Handbook of satellite applications

    CERN Document Server

    Madry, Scott; Camacho-Lara, Sergio

    2013-01-01

    Top space experts from around the world have collaborated to produce this comprehensive, authoritative, and clearly illustrated reference guide to the fast growing, multi-billion dollar field of satellite applications and space communications. This handbook, done under the auspices of the International Space University based in France, addresses not only system technologies but also examines market dynamics, technical standards and regulatory constraints. The handbook is a completely multi-disciplinary reference book that covers, in an in-depth fashion, the fields of satellite telecommunications, Earth observation, remote sensing, satellite navigation, geographical information systems, and geosynchronous meteorological systems. It covers current practices and designs as well as advanced concepts and future systems. It provides a comparative analysis of the common technologies and design elements for satellite application bus structures, thermal controls, power systems, stabilization techniques, telemetry, com...

  14. Handbook of electroporation

    CERN Document Server

    2017-01-01

    This major reference work is a one-shot knowledge base on electroporation and the use of pulsed electric fields of high intensity and their use in biology, medicine, biotechnology, and food and environmental technologies. The Handbook offers a widespread and well-structured compilation of 156 chapters ranging from the foundations to applications in industry and hospital. It is edited and written by most prominent researchers in the field. With regular updates and growing in its volume it is suitable for academic readers and researchers regardless of their disciplinary expertise, and will also be accessible to students and serious general readers. The Handbook's 276 authors have established scholarly credentials and come from a wide range of disciplines. This is crucially important in a highly interdisciplinary field of electroporation and the use of pulsed electric fields of high intensity and its applications in different fields from medicine, biology, food proce ssing, agriculture, process engineering, en...

  15. Springer handbook of spacetime

    CERN Document Server

    Petkov, Vesselin

    2014-01-01

    The Springer Handbook of Spacetime is dedicated to the ground-breaking paradigm shifts embodied in the two relativity theories, and describes in detail the profound reshaping of physical sciences they ushered in. It includes in a single volume chapters on foundations, on the underlying mathematics, on physical and astrophysical implications, experimental evidence and cosmological predictions, as well as chapters on efforts to unify general relativity and quantum physics. The Handbook can be used as a desk reference by researchers in a wide variety of fields, not only by specialists in relativity but also by researchers in related areas that either grew out of, or are deeply influenced by, the two relativity theories: cosmology, astronomy and astrophysics, high energy physics, quantum field theory, mathematics, and philosophy of science. It should also serve as a valuable resource for graduate students and young researchers entering these areas, and for instructors who teach courses on these subjects. The Han...

  16. Industrial communication technology handbook

    CERN Document Server

    Zurawski, Richard

    2014-01-01

    Featuring contributions from major technology vendors, industry consortia, and government and private research establishments, the Industrial Communication Technology Handbook, Second Edition provides comprehensive and authoritative coverage of wire- and wireless-based specialized communication networks used in plant and factory automation, automotive applications, avionics, building automation, energy and power systems, train applications, and more.New to the Second Edition:46 brand-new chapters and 21 substantially revised chaptersInclusion of the latest, most significant developments in spe

  17. The clinical nanomedicine handbook

    CERN Document Server

    Brenner, Sara

    2013-01-01

    Designed to foster a stronger awareness and exploration of the subject by practicing clinicians, medical researchers and scientists, The Clinical Nanomedicine Handbook discusses the integration of nanotechnology, biology, and medicine from a clinical point of view. The book highlights relevant research and applications by specialty; it examines nanotechnology in depth, and the potential to solve medical problems. It also increases literacy in nanotechnology, and allows for more effective communication and collaboration between disciplines. Details worldwide developments in nanomedicine Provide

  18. Practical electronics handbook

    CERN Document Server

    Sinclair, Ian R

    2013-01-01

    Practical Electronics Handbook, Third Edition provides the frequently used and highly applicable principles of electronics and electronic circuits.The book contains relevant information in electronics. The topics discussed in the text include passive and active discrete components; linear and digital I.C.s; microprocessors and microprocessor systems; digital-analogue conversions; computer aids in electronics design; and electronic hardware components.Electronic circuit constructors, service engineers, electronic design engineers, and anyone with an interest in electronics will find the book ve

  19. Newnes communications technology handbook

    CERN Document Server

    Lewis, Geoff

    1994-01-01

    Newnes Communications Technology Handbook provides a discussion on different topics relevant to communications technology. The book is comprised of 39 chapters that tackle a wide variety of concern in communications technology. The coverage of the text includes technologies, such as analog digital communications systems, radio frequency receiver, and satellite systems. The book also discusses some methods and techniques used in communications technology, including mixer signal processing, modulation and demodulation, and spread spectrum techniques. The text will be of great use to engineers, t

  20. Fixed mobile convergence handbook

    CERN Document Server

    Ahson, Syed A

    2010-01-01

    From basic concepts to future directions, this handbook provides technical information on all aspects of fixed-mobile convergence (FMC). The book examines such topics as integrated management architecture, business trends and strategic implications for service providers, personal area networks, mobile controlled handover methods, SIP-based session mobility, and supervisory and notification aggregator service. Case studies are used to illustrate technical and systematic implementation of unified and rationalized internet access by fixed-mobile network convergence. The text examines the technolo

  1. Joint Program Management Handbook

    Science.gov (United States)

    1994-12-01

    the Engieermg and Manufacuring Devopment Phase. Nfilestoae HI- Develommen Annros Devopment approval marks a significant step for any program, but it is...to review concept formulaton. Systems Engilneertn As with service programs, systems engineering in joint program management is an essential tool . I...MANAGEMENT HANDBOOK On=e wd Umawtaiutt As discussed in Chapter 7, systems analysis of relationships is a usef tool for joint program managers. The joint

  2. The universal access handbook

    CERN Document Server

    Stephanidis, Constantine

    2009-01-01

    In recent years, the field of Universal Access has made significant progress in consolidating theoretical approaches, scientific methods and technologies, as well as in exploring new application domains. Increasingly, professionals in this rapidly maturing area require a comprehensive and multidisciplinary resource that addresses current principles, methods, and tools. Written by leading international authorities from academic, research, and industrial organizations and nonmarket institutions, The Universal Access Handbook covers the unfolding scientific, methodological, technological, and pol

  3. CTBT technical issues handbook

    Energy Technology Data Exchange (ETDEWEB)

    Zucca, J.J. [ed.

    1994-05-01

    The purpose of this handbook is to give the nonspecialist in nuclear explosion physics and nuclear test monitoring an introduction to the topic as it pertains to a Comprehensive Test Ban Treaty (CTBT). The authors have tried to make the handbook visually oriented, with figures paired to short discussions. As such, the handbook may be read straight through or in sections. The handbook covers four main areas and ends with a glossary, which includes both scientific terms and acronyms likely to be encountered during CTBT negotiations. The following topics are covered: (1) Physics of nuclear explosion experiments. This is a description of basic nuclear physics and elementary nuclear weapon design. Also discussed are testing practices. (2) Other nuclear experiments. This section discusses experiments that produce small amounts of nuclear energy but differ from explosion experiments discussed in the first chapter. This includes the type of activities, such as laser fusion, that would continue after a CTBT is in force. (3) Monitoring tests in various environments. This section describes the different physical environments in which a test could be conducted (underground, in the atmosphere, in space, underwater, and in the laboratory); the sources of non-nuclear events (such as earthquakes and mining operations); and the opportunities for evasion. (4) On-site inspections. A CTBT is likely to include these inspections as an element of the verification provisions, in order to resolve the nature of ambiguous events. This chapter describes some technical considerations and technologies that are likely to be useful. (5) Selecting verification measures. This chapter discusses the uncertain nature of the evidence from monitoring systems and how compliance judgments could be made, taking the uncertainties into account. It also discusses how to allocate monitoring resources, given the likelihood of testing by various countries in various environments.

  4. Energy emergency handbook

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    This Handbook identifies selected state and federal measures available to mitigate the impact of an energy emergency, and provides a comprehensive energy emergency communications directory. In the case of state remedial actions, particular emphasis has been placed on typical implementation procedures and likely impacts. The discussions of federal actions focus on initation and implementation procedures. The directory is designed to facilitate communications of all types (telephone, Telex, TWX, or facsimile) among key energy emergency officials in the federal and state governments.

  5. Handbook of networking & connectivity

    CERN Document Server

    McClain, Gary R

    1994-01-01

    Handbook of Networking & Connectivity focuses on connectivity standards in use, including hardware and software options. The book serves as a guide for solving specific problems that arise in designing and maintaining organizational networks.The selection first tackles open systems interconnection, guide to digital communications, and implementing TCP/IP in an SNA environment. Discussions focus on elimination of the SNA backbone, routing SNA over internets, connectionless versus connection-oriented networks, internet concepts, application program interfaces, basic principles of layering, proto

  6. Power vacuum tubes handbook

    CERN Document Server

    Whitaker, Jerry

    2012-01-01

    Providing examples of applications, Power Vacuum Tubes Handbook, Third Edition examines the underlying technology of each type of power vacuum tube device in common use today. The author presents basic principles, reports on new development efforts, and discusses implementation and maintenance considerations. Supporting mathematical equations and extensive technical illustrations and schematic diagrams help readers understand the material. Translate Principles into Specific Applications This one-stop reference is a hands-on guide for engineering personnel involved in the design, specification,

  7. Handbook on electronic commerce

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, M. [Illinois Univ., Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology; Blanning, R. [Vanderbilt Univ., Nashville, TN (United States). Owen Graduate School of Management; Strader, T. [Iowa State Univ., Ames, IA (United States). Management Information Systems; Whinston, A. [eds.] [Texas Univ., Austin, TX (United States). Dept. of Management Science and Information Systems

    2000-07-01

    The world is undergoing a revolution to a digital economy, with pronounced implications for corporate strategy, marketing, operations, information systems, customer services, global supply-chain management, and product distribution. This handbook examines the aspects of electronic commerce, including electronic storefront, on-line business, consumer interface, business-to-business networking, digital payment, legal issues, information product development, and electronic business models. Indispensable for academics, students and professionals who are interested in Electronic Commerce and Internet Business. (orig.)

  8. Handbook of industrial lighting

    CERN Document Server

    Lyons, Stanley L

    2013-01-01

    Handbook of Industrial Lighting is a practical guide on the specification, design, installation, operation, and maintenance of lighting in industrial premises. Coverage of the book includes the importance of good localized lighting; the different lighting schemes; lighting for difficult visual tasks; lighting in consideration to safety; and emergency lighting. The book also includes the practical, thermal, ventilation, and energy considerations; lighting in different environments; maintenance of lighting installations; and the cost benefits of efficient lighting. Appendices include useful info

  9. Standard interface file handbook

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro, A.; Huria, H.C. (Cincinnati Univ., OH (United States))

    1992-10-01

    This handbook documents many of the standard interface file formats that have been adopted by the US Department of Energy to facilitate communications between and portability of, various large reactor physics and radiation transport software packages. The emphasis is on those files needed for use of the VENTURE/PC diffusion-depletion code system. File structures, contents and some practical advice on use of the various files are provided.

  10. Handbook of wafer bonding

    CERN Document Server

    Ramm, Peter; Taklo, Maaike M V

    2011-01-01

    Written by an author and editor team from microsystems companies and industry-near research organizations, this handbook and reference presents dependable, first-hand information on bonding technologies.In the first part, researchers from companies and institutions around the world discuss the most reliable and reproducible technologies for the production of bonded wafers. The second part is devoted to current and emerging applications, including microresonators, biosensors and precise measuring devices.

  11. Site characterization handbook

    Energy Technology Data Exchange (ETDEWEB)

    1988-06-01

    This Handbook discusses both management and technical elements that should be considered in developing a comprehensive site characterization program. Management elements typical of any project of a comparable magnitude and complexity are combined with a discussion of strategies specific to site characterization. Information specific to the technical elements involved in site characterization is based on guidance published by the Nuclear Regulatory Commission (NRC) with respect to licensing requirements for LLW disposal facilities. The objective of this Handbook is to provide a reference for both NRC Agreement States and non-Agreement States for use in developing a comprehensive site characterization program that meets the specific objectives of the State and/or site developer/licensee. Each site characterization program will vary depending on the objectives, licensing requirements, schedules/budgets, physical characteristics of the site, proposed facility design, and the specific concerns raised by government agencies and the public. Therefore, the Handbook is not a prescriptive guide to site characterization. 18 refs., 6 figs.

  12. Site characterization handbook

    Energy Technology Data Exchange (ETDEWEB)

    1988-06-01

    This Handbook discusses both management and technical elements that should be considered in developing a comprehensive site characterization program. Management elements typical of any project of a comparable magnitude and complexity are combined with a discussion of strategies specific to site characterization. Information specific to the technical elements involved in site characterization is based on guidance published by the Nuclear Regulatory Commission (NRC) with respect to licensing requirements for LLW disposal facilities. The objective of this Handbook is to provide a reference for both NRC Agreement States and non-Agreement States for use in developing a comprehensive site characterization program that meets the specific objectives of the State and/or site developer/licensee. Each site characterization program will vary depending on the objectives, licensing requirements, schedules/budgets, physical characteristics of the site, proposed facility design, and the specific concerns raised by government agencies and the public. Therefore, the Handbook is not a prescriptive guide to site characterization. 18 refs., 6 figs.

  13. Handbook of metaheuristics

    CERN Document Server

    Potvin, Jean-Yves

    2010-01-01

    “… an excellent book if you want to learn about a number of individual metaheuristics." (U. Aickelin, Journal of the Operational Research Society, Issue 56, 2005, on the First Edition) The first edition of the Handbook of Metaheuristics was published in 2003 under the editorship of Fred Glover and Gary A. Kochenberger. Given the numerous developments observed in the field of metaheuristics in recent years, it appeared that the time was ripe for a second edition of the Handbook. When Glover and Kochenberger were unable to prepare this second edition, they suggested that Michel Gendreau and Jean-Yves Potvin should take over the editorship, and so this important new edition is now available. Through its 21 chapters, this second edition is designed to provide a broad coverage of the concepts, implementations and applications in this important field of optimization. Original contributors either revised or updated their work, or provided entirely new chapters. The Handbook now includes updated chapters on the b...

  14. Handbook for TEAC Auditors, 2011

    Science.gov (United States)

    Teacher Education Accreditation Council, 2011

    2011-01-01

    This handbook is primarily for the Teacher Education Accreditation Council (TEAC) auditor. It is intended to help in preparing for audits of "Inquiry Briefs" and "Inquiry Brief Proposals" and to contribute to the writing of the audit report. This handbook contains a full description of the audit process, the responsibilities of…

  15. Anmeldelse: The Writer's Handbooks 2009

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2008-01-01

    Anmeldelse af: Barry Turner (red.) (2008) The Writer’s Handbook 2009. The complete guide for all writers, publishers, editors, agents, and broadcasts. New York: MacMillan Barry Turner (red.) (2008) The Screenwriter’s Handbook 2009. The essential companion for screenwriters. New York: MacMillan...

  16. Handbook on Innovations in Learning

    Science.gov (United States)

    Murphy, Marilyn, Ed.; Redding, Sam, Ed.; Twyman, Janet, Ed.

    2013-01-01

    The "Handbook on Innovations in Learning" focuses on innovations--both methodological and technological--in teaching and learning that promise to surpass standard practice in achieving learning outcomes for students. The experts who have written chapters in this Handbook first identify the underlying principles of learning and then…

  17. Colgate University Faculty Handbook, 1970.

    Science.gov (United States)

    Colgate Univ., Hamilton, NY.

    Designed to supplement the university catalog and handbook, this 1970 faculty handbook is primarily for the information and guidance of new members of the faculty. The community is described, and university organization and campus governance outlined. Specific details are reported on various topics, including: faculty use of college facilities,…

  18. Pottery from Pakistan. A Handbook.

    Science.gov (United States)

    Rammage, Alix

    One of three handbooks dealing with pottery traditions from around the world, this packet draws together information about historical, ethnographic, and pottery traditions of Pakistan. The handbook begins with a brief discussion of Pakistan's land and people, a short history of Pakistan, Islamic pottery traditions, and Pakistan potters and…

  19. Anmeldelse: The Writer's Handbooks 2009

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2008-01-01

    Anmeldelse af: Barry Turner (red.) (2008) The Writer’s Handbook 2009. The complete guide for all writers, publishers, editors, agents, and broadcasts. New York: MacMillan Barry Turner (red.) (2008) The Screenwriter’s Handbook 2009. The essential companion for screenwriters. New York: MacMillan...

  20. Consumer's Resource Handbook. 1988 Edition.

    Science.gov (United States)

    Office of Consumer Affairs, Washington, DC.

    This handbook is intended to help consumers exercise their rights in the marketplace in three ways: (1) it shows how to communicate more effectively with manufacturers, retailers, and service providers; (2) it is a self-help manual for resolving in dividual consumer complaints; and (3) it lists helpful sources of assistance. The handbook has two…

  1. Mechanical Design Handbook for Elastomers

    Science.gov (United States)

    Darlow, M.; Zorzi, E.

    1986-01-01

    Mechanical Design Handbook for Elastomers reviews state of art in elastomer-damper technology with particular emphasis on applications of highspeed rotor dampers. Self-contained reference but includes some theoretical discussion to help reader understand how and why dampers used for rotating machines. Handbook presents step-by-step procedure for design of elastomer dampers and detailed examples of actual elastomer damper applications.

  2. The small library manager's handbook

    CERN Document Server

    Graves, Alice

    2014-01-01

    The Small Library Manager's Handbook is for librarians working in all types of small libraries. It covers the everyday nuts-and-bolts operations that all librarians must perform. This handbook, written by experts who are small librarians themselves, will help all small librarians to do multiple jobs at the same time.

  3. Revising Academic Library Governance Handbooks

    OpenAIRE

    2015-01-01

    Original Image by Flickr user Sasquatch 1 (CC BY 2.0), with minimal modification by C. Strunk (10 June 2015). In Brief Regardless of our status (tenure track, non-tenure track, staff, and/or union), academic librarians at colleges and universities may use a handbook or similar document as a framework for self-governance. These handbooks typically cover rank […

  4. ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

    CERN Multimedia

    Visual Media Office

    2013-01-01

    ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

  5. Revising Academic Library Governance Handbooks

    Directory of Open Access Journals (Sweden)

    Jen Stevens

    2015-07-01

    Full Text Available Regardless of our status (tenure track, non-tenure track, staff, and/or union, academic librarians at colleges and universities may use a handbook or similar document as a framework for self-governance. These handbooks typically cover rank descriptions, promotion requirements, and grievance rights, among other topics. Unlike employee handbooks used in the corporate world, these documents may be written and maintained by academic librarians themselves1. In 2010, a group of academic librarians at George Mason University was charged with revising our Librarians’ Handbook. Given the dearth of literature about academic librarians’ handbooks and their revision, we anticipate our library colleagues in similar situations will benefit from our experience and recommendations.

  6. River-Based Experiential Learning: the Bear River Fellows Program

    Science.gov (United States)

    Rosenberg, D. E.; Shirley, B.; Roark, M. F.

    2012-12-01

    The Department of Civil and Environmental Engineering, Outdoor Recreation, and Parks and Recreation programs at Utah State University (USU) have partnered to offer a new, unique river-based experiential learning opportunity for undergraduates called the Bear River Fellows Program. The program allows incoming freshmen Fellows to experience a river first hand during a 5-day/4-night river trip on the nearby Bear River two weeks before the start of their first Fall semester. As part of the program, Fellows will navigate the Bear River in canoes, camp along the banks, interact with local water and environmental managers, collect channel cross section, stream flow, vegetation cover, and topological complexity data, meet other incoming freshmen, interact with faculty and graduate students, develop boating and leadership skills, problem solve, and participate as full members of the trip team. Subsequently, Fellows will get paid as undergraduate researchers during their Fall and Spring Freshman semesters to analyze, synthesize, and present the field data they collect. The program is a collaborative effort between two USU academic units and the (non-academic) division of Student Services and supports a larger National Science Foundation funded environmental modelling and management project for the lower Bear River, Utah watershed. We have advertised the program via Facebook and emails to incoming USU freshmen, received 35 applications (60% women), and accepted 5 Fellows into the program (3 female and 2 male). The river trip departs August 14, 2012. The poster will overview the Bear River Fellows Program and present qualitative and preliminary outcomes emerging from the trip and Fellows' work through the Fall semester with the field data they collect. We will also undertake more rigorous and longer longitudinal quantitative evaluation of Program outcomes (for example, in problem-solving and leadership) both in Spring 2013 and in subsequent 2013 and 2014 offerings of the

  7. Handbook of space security policies, applications and programs

    CERN Document Server

    Hays, Peter; Robinson, Jana; Moura, Denis; Giannopapa, Christina

    2015-01-01

    Space Security involves the use of space (in particular communication, navigation, earth observation, and electronic intelligence satellites) for military and security purposes on earth and also the maintenance of space (in particular the earth orbits) as safe and secure areas for conducting peaceful activities. The two aspects can be summarized as "space for security on earth" and “the safeguarding of space for peaceful endeavors.” The Handbook will provide a sophisticated, cutting-edge resource on the space security policy portfolio and the associated assets, assisting fellow members of the global space community and other interested policy-making and academic audiences in keeping abreast of the current and future directions of this vital dimension of international space policy. The debate on coordinated space security measures, including relevant 'Transparency and Confidence-Building Measures,' remains at a relatively early stage of development. The book offers a comprehensive description of the variou...

  8. Maeve Boland selected as AGU Congressional Science Fellow

    Science.gov (United States)

    Chell, Kaitlin

    2009-10-01

    Maeve Boland, research assistant professor at the Colorado School of Mines, is AGU's 2009-2010 Congressional Science Fellow. Boland, who has a Ph.D. in geology from the Colorado School of Mines, is spending a year working in the office of U.S. Sen. Byron Dorgan (D-N. D.). She was selected in March by AGU's Committee on Public Affairs after a competitive interview process, and she is AGU's 32nd Congressional Science Fellow. In September, Boland and 31 other Congressional Science Fellows participated in a 2-week course in politics and the legislative process put on by the American Association for the Advancement of Science. She then interviewed with a number of congressional offices and was offered a position in the office of Sen. Dorgan, who chairs the Senate Appropriations Subcommittee on Energy and Water Development and is a member of the Committee on Energy and Natural Resources and the Committee on Commerce, Science, and Transportation. Boland is working as a legislative fellow carrying out a range of duties such as organizing congressional hearings, crafting legislation, advising legislators on votes, meeting with lobbyists, and writing speeches. Fellows also are often asked to assist their senator or representative during committee hearings and on the U.S. House or Senate floors during legislative debates.

  9. Geritalk: Communication Skills Training for Geriatrics and Palliative Medicine Fellows

    Science.gov (United States)

    Kelley, Amy S.; Back, Anthony L.; Arnold, Robert M.; Goldberg, Gabrielle R.; Lim, Betty B.; Litrivis, Evgenia; Smith, Cardinale B.; O’Neill, Lynn B.

    2011-01-01

    Expert communication is essential to high quality care for older patients with serious illness. While the importance of communication skills is widely recognized, formal curricula for teaching communication skills to geriatrics and palliative medicine fellows is often inadequate or unavailable. We drew upon the educational principles and format of an evidence-based, interactive teaching method, to develop an intensive communication skills training course designed specifically to address the common communication challenges faced by geriatrics and palliative medicine fellows. The 2-day retreat, held away from the hospital environment, included large-group overview presentations, small-group communication skills practice, and development of future skills practice commitment. Faculty received in-depth training in small-group facilitation techniques prior to the course. Geriatrics and palliative medicine fellows were recruited to participate in the course and 100% (n=18) enrolled. Overall satisfaction with the course was very high (mean 4.8 on 5-point scale). Compared to before the course, fellows reported an increase in self-assessed preparedness for specific communication challenges (mean increase 1.4 on 5-point scale, pskills practice (mean 4.3 on 5-point scale). In sum, the intensive communication skills program, tailored to the specific needs of geriatrics and palliative medicine fellows, improved fellows’ self-assessed preparedness for challenging communication tasks and provided a model for ongoing deliberate practice of communication skills. PMID:22211768

  10. The Critical Care Communication project: improving fellows' communication skills.

    Science.gov (United States)

    Arnold, Robert M; Back, Anthony L; Barnato, Amber E; Prendergast, Thomas J; Emlet, Lillian L; Karpov, Irina; White, Patrick H; Nelson, Judith E

    2015-04-01

    The aim of this study was to develop an evidence-based communication skills training workshop to improve the communication skills of critical care fellows. Pulmonary and critical care fellows (N = 38) participated in a 3-day communication skills workshop between 2008 and 2010 involving brief didactic talks, faculty demonstration of skills, and faculty-supervised small group skills practice sessions with simulated families. Skills included the following: giving bad news, achieving consensus on goals of therapy, and discussing the limitations of life-sustaining treatment. Participants rated their skill levels in a pre-post survey in 11 core communication tasks using a 5-point Likert scale. Of 38 fellows, 36 (95%) completed all 3 days of the workshop. We compared pre and post scores using the Wilcoxon signed rank test. Overall, self-rated skills increased for all 11 tasks. In analyses by participant, 95% reported improvement in at least 1 skill; with improvement in a median of 10 of 11 skills. Ninety-two percent rated the course as either very good/excellent, and 80% recommended that it be mandatory for future fellows. This 3-day communication skills training program increased critical care fellows' self-reported family meeting communication skills. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. A jolly good call for Marie Curie Fellows

    CERN Multimedia

    2009-01-01

    A new funding opportunity to train young researchers has just been announced by the European Commission. One of the calls within FP7 Marie Curie Actions requests proposals for Initial Training Network (ITN) projects, with a deadline of 22 December 2009. Project proposals are strongly encouraged at CERN and authors can receive support and guidance from the Marie Curie Steering Group. Winnie Wong: "I wouldn’t have considered a PhD if I hadn’t been a Marie Curie fellow" Dan Savu: "It’s the best of both worlds: training plus working in an international organisation" ITN projects have one key aim: training. Academic and industrial partners work together to form a network to recruit and train Marie Curie Fellows. Fellows are young researchers (typically PhD-level) from any country who combine project-based research with tailor-made training programmes, ...

  12. Handbook of mathematics

    CERN Document Server

    Kuipers, L

    1969-01-01

    International Series of Monographs in Pure and Applied Mathematics, Volume 99: Handbook of Mathematics provides the fundamental mathematical knowledge needed for scientific and technological research. The book starts with the history of mathematics and the number systems. The text then progresses to discussions of linear algebra and analytical geometry including polar theories of conic sections and quadratic surfaces. The book then explains differential and integral calculus, covering topics, such as algebra of limits, the concept of continuity, the theorem of continuous functions (with examp

  13. Handbook of molecular plasmonics

    CERN Document Server

    Sala, Fabio Della

    2013-01-01

    While several reviews and books on surface nanophotonics and fluorescence spectroscopy are available, an updated focus on molecular plasmonics, including both theoretical methods and experimental aspects, is still lacking. This handbook is a comprehensive overview on the physics of the plasmon-emitter interaction, ranging from electromagnetism to quantum mechanics, from metal-enhanced fluorescence to surface-enhanced Raman scattering, from optical microscopy to synthesis of metal nanoparticles, filling the gap in the literature of this merging field. It allows experimentalists to have a solid

  14. AVR RISC microcontroller handbook

    CERN Document Server

    Kuhnel, Claus

    1998-01-01

    The AVR RISC Microcontroller Handbook is a comprehensive guide to designing with Atmel's new controller family, which is designed to offer high speed and low power consumption at a lower cost. The main text is divided into three sections: hardware, which covers all internal peripherals; software, which covers programming and the instruction set; and tools, which explains using Atmel's Assembler and Simulator (available on the Web) as well as IAR's C compiler.Practical guide for advanced hobbyists or design professionalsDevelopment tools and code available on the Web

  15. The sound handbook

    CERN Document Server

    Crook, Tim

    2013-01-01

    'Tim Crook has written an important and much-needed book, and its arrival on our shelves has come at a highly appropriate time.' Professor Seán Street, Bournemouth UniversityThe Sound Handbook maps theoretical and practical connections between the creation and study of sound across the multi-media spectrum of film, radio, music, sound art, websites, animation and computer games entertainment, and stage theatre. Using an interdisciplinary approach Tim Crook explores the technologies, philosophies and cultural issues involved in making a

  16. Computer Security Handbook

    CERN Document Server

    Bosworth, Seymour; Whyne, Eric

    2012-01-01

    The classic and authoritative reference in the field of computer security, now completely updated and revised With the continued presence of large-scale computers; the proliferation of desktop, laptop, and handheld computers; and the vast international networks that interconnect them, the nature and extent of threats to computer security have grown enormously. Now in its fifth edition, Computer Security Handbook continues to provide authoritative guidance to identify and to eliminate these threats where possible, as well as to lessen any losses attributable to them. With seventy-seven chapter

  17. Computer science handbook

    CERN Document Server

    Tucker, Allen B

    2004-01-01

    Due to the great response to the famous Computer Science Handbook edited by Allen B. Tucker, … in 2004 Chapman & Hall/CRC published a second edition of this comprehensive reference book. Within more than 70 chapters, every one new or significantly revised, one can find any kind of information and references about computer science one can imagine. … All in all, there is absolute nothing about computer science that can not be found in the encyclopedia with its 110 survey articles …-Christoph Meinel, Zentralblatt MATH

  18. Steel designers' handbook

    CERN Document Server

    Gorenc, Branko; Tinyou, Ron

    2012-01-01

    The Revised 7th Edition of Steel Designers' Handbook is an invaluable tool for all practising structural, civil and mechanical engineers as well as engineering students at university and TAFE in Australia and New Zealand. It has been prepared in response to changes in the design Standard AS 4100, the structural Design Actions Standards, AS /ANZ 1170, other processing Standards such as welding and coatings, updated research as well as feedback from users. This edition is based on Australian Standard (AS) 4100: 1998 and subsequent amendments. The worked numerical examples in the book have been e

  19. Handbook of visual communications

    CERN Document Server

    Hang, Hseuh-Ming

    1995-01-01

    Handbook of Visual Communications explores the latest developments in the field, such as model-based image coding, and provides readers with insight into possible future developments.Key Features* Displays comprehensive coverage from fundamental theory to international standards and VLSI design* Includes 518 pages of contributions from well-known experts* [please keep this feature current with the page count]* Presents state-of-the-art knowledge--the most up-to-date and accurate information on various topics in the field* Provides an extensive overview of international standards for industrial

  20. Handbook of Plastic Welding

    DEFF Research Database (Denmark)

    Islam, Aminul

    The purpose of this document is to summarize the information about the laser welding of plastic. Laser welding is a matured process nevertheless laser welding of micro dimensional plastic parts is still a big challenge. This report collects the latest information about the laser welding of plasti...... as a knowledge handbook for laser welding of plastic components. This document should provide the information for all aspects of plastic laser welding and help the design engineers to take all critical issues into consideration from the very beginning of the design phase....

  1. The SQUID Handbook

    CERN Document Server

    Braginski, Alex I

    2006-01-01

    This two-volume handbook offers a comprehensive and well coordinated presentation of SQUIDs (Superconducting Quantum Interference Devices), including device fundamentals, design, technology, system construction and multiple applications. It is intended to bridge the gap between fundamentals and applications, and will be a valuable textbook reference for graduate students and for professionals engaged in SQUID research and engineering. It will also be of use to specialists in multiple fields of practical SQUID applications, from human brain research and heart diagnostics to airplane and nuclear

  2. Electric power distribution handbook

    CERN Document Server

    Short, Thomas Allen

    2014-01-01

    Of the ""big three"" components of electrical infrastructure, distribution typically gets the least attention. In fact, a thorough, up-to-date treatment of the subject hasn't been published in years, yet deregulation and technical changes have increased the need for better information. Filling this void, the Electric Power Distribution Handbook delivers comprehensive, cutting-edge coverage of the electrical aspects of power distribution systems. The first few chapters of this pragmatic guidebook focus on equipment-oriented information and applications such as choosing transformer connections,

  3. Seals and sealing handbook

    CERN Document Server

    Flitney, Robert K

    2014-01-01

    Seals and Sealing Handbook, 6th Edition provides comprehensive coverage of sealing technology, bringing together information on all aspects of this area to enable you to make the right sealing choice. This includes detailed coverage on the seals applicable to static, rotary and reciprocating applications, the best materials to use in your sealing systems, and the legislature and regulations that may impact your sealing choices. Updated in line with current trends this updated reference provides the theory necessary for you to select the most appropriate seals for the job and with its 'Failur

  4. Communications technology handbook

    CERN Document Server

    Lewis, Geoff

    2013-01-01

    This is the first point of reference for the communications industries. It offers an introduction to a wide range of topics and concepts encountered in the field of communications technology. Whether you are looking for a simple explanation, or need to go into a subject in more depth, the Communications Technology Handbook provides all the information you need in one single volume.This second edition has been updated to include the latest technology including: Video on DemandWire-less Distribution systemsHigh spee

  5. The VLSI handbook

    CERN Document Server

    Chen, Wai-Kai

    2007-01-01

    Written by a stellar international panel of expert contributors, this handbook remains the most up-to-date, reliable, and comprehensive source for real answers to practical problems. In addition to updated information in most chapters, this edition features several heavily revised and completely rewritten chapters, new chapters on such topics as CMOS fabrication and high-speed circuit design, heavily revised sections on testing of digital systems and design languages, and two entirely new sections on low-power electronics and VLSI signal processing. An updated compendium of references and othe

  6. Circuits and filters handbook

    CERN Document Server

    Chen, Wai-Kai

    2003-01-01

    A bestseller in its first edition, The Circuits and Filters Handbook has been thoroughly updated to provide the most current, most comprehensive information available in both the classical and emerging fields of circuits and filters, both analog and digital. This edition contains 29 new chapters, with significant additions in the areas of computer-aided design, circuit simulation, VLSI circuits, design automation, and active and digital filters. It will undoubtedly take its place as the engineer's first choice in looking for solutions to problems encountered in the design, analysis, and behavi

  7. HVAC systems design handbook

    CERN Document Server

    Haines, Roger W

    2010-01-01

    Thoroughly updated with the latest codes, technologies, and practices, this all-in-one resource provides details, calculations, and specifications for designing efficient and effective residential, commercial, and industrial HVAC systems. HVAC Systems Design Handbook, Fifth Edition, features new information on energy conservation and computer usage for design and control, as well as the most recent International Code Council (ICC) Mechanical Code requirements. Detailed illustrations, tables, and essential HVAC equations are also included. This comprehensive guide contains everything you need to design, operate, and maintain peak-performing HVAC systems.

  8. Handbook of linear algebra

    CERN Document Server

    Hogben, Leslie

    2013-01-01

    With a substantial amount of new material, the Handbook of Linear Algebra, Second Edition provides comprehensive coverage of linear algebra concepts, applications, and computational software packages in an easy-to-use format. It guides you from the very elementary aspects of the subject to the frontiers of current research. Along with revisions and updates throughout, the second edition of this bestseller includes 20 new chapters.New to the Second EditionSeparate chapters on Schur complements, additional types of canonical forms, tensors, matrix polynomials, matrix equations, special types of

  9. The branch librarians' handbook

    CERN Document Server

    Rivers, Vickie

    2004-01-01

    ""Recommended""--Booklist; ""an excellent addition...highly recommended""--Public Libraries; ""clear...very sound advice...strongly recommend""--Catholic Library World; ""excellent resource...organized...well written""--Against the Grain; ""interesting...thoroughly practical...a very good book...well organized...clearly written""--ARBA. This handbook covers a wide variety of issues that the branch librarian must deal with every day. Chapters are devoted to mission statements (the Dallas Public Library and Dayton Metro Library mission statements are highlighted as examples), library systems,

  10. Heat pump planning handbook

    CERN Document Server

    Bonin, Jürgen

    2015-01-01

    The Heat Pump Planning Handbook contains practical information and guidance on the design, planning and selection of heat pump systems, allowing engineers, designers, architects and construction specialists to compare a number of different systems and options. Including detailed descriptions of components and their functions and reflecting the current state of technology this guide contains sample tasks and solutions as well as new model calculations and planning evaluations. Also economic factors and alternative energy sources are covered, which are essential at a time of rising heat costs. T

  11. Handbook of web surveys

    CERN Document Server

    Bethlehem, Jelke

    2011-01-01

    BEST PRACTICES TO CREATE AND IMPLEMENTHIGHLY EFFECTIVE WEB SURVEYS Exclusively combining design and sampling issues, Handbook of Web Surveys presents a theoretical yet practical approach to creating and conducting web surveys. From the history of web surveys to various modes of data collection to tips for detecting error, this book thoroughly introduces readers to the this cutting-edge technique and offers tips for creating successful web surveys. The authors provide a history of web surveys and go on to explore the advantages and disadvantages of this mode of dat

  12. Handbook for sound engineers

    CERN Document Server

    Ballou, Glen

    2015-01-01

    Handbook for Sound Engineers is the most comprehensive reference available for audio engineers, and is a must read for all who work in audio.With contributions from many of the top professionals in the field, including Glen Ballou on interpretation systems, intercoms, assistive listening, and fundamentals and units of measurement, David Miles Huber on MIDI, Bill Whitlock on audio transformers and preamplifiers, Steve Dove on consoles, DAWs, and computers, Pat Brown on fundamentals, gain structures, and test and measurement, Ray Rayburn on virtual systems, digital interfacing, and preamplifiers

  13. Capability Handbook- offline metrology

    DEFF Research Database (Denmark)

    Islam, Aminul; Marhöfer, David Maximilian; Tosello, Guido

    This offline metrological capability handbook has been made in relation to HiMicro Task 3.3. The purpose of this document is to assess the metrological capability of the HiMicro partners and to gather the information of all available metrological instruments in the one single document. It provides...... a quick overview of what is possible today by the state of the art, what the HiMicro consortium can do and what metrological requirements we have concerning the HiMicro industrial demonstrators....

  14. Project Management Handbook

    OpenAIRE

    Hyttinen, Kirsi

    2017-01-01

    “Project Management has become a core competency, and nearly every manager is involved in managing one or more projects. Moreover, the role of projects in organisations is receiving increasing attention.” In almost every organisation, projects are planned and run on a daily basis. At the same time, we are living in a hectic world with no time for massive reading exercises. This handbook aims to support both perspectives: to run projects smoothly, and to quickly find topics that are releva...

  15. Embedded systems handbook

    CERN Document Server

    Zurawski, Richard

    2005-01-01

    Embedded systems are nearly ubiquitous, and books on individual topics or components of embedded systems are equally abundant. Unfortunately, for those designers who thirst for knowledge of the big picture of embedded systems there is not a drop to drink. Until now. The Embedded Systems Handbook is an oasis of information, offering a mix of basic and advanced topics, new solutions and technologies arising from the most recent research efforts, and emerging trends to help you stay current in this ever-changing field.With preeminent contributors from leading industrial and academic institutions

  16. Handbook of information science

    CERN Document Server

    Stock, Wolfgang G

    2013-01-01

    Dealing with information is one of the vital skills in thetwenty-first century. It takes a fair degree of information savvy to create, represent and supply information as well as to search for and retrieve relevant knowledge. This Handbook is a basic work of information science, providing a comprehensive overview of the current state of information retrieval and knowledge representation. It addresses readers from all professions and scientific disciplines, but particularly scholars, practitioners and students of Information Science, Library Science, Computer Science, Information Management, an

  17. Handbook for sound engineers

    CERN Document Server

    Ballou, Glen

    2013-01-01

    Handbook for Sound Engineers is the most comprehensive reference available for audio engineers. All audio topics are explored: if you work on anything related to audio you should not be without this book! The 4th edition of this trusted reference has been updated to reflect changes in the industry since the publication of the 3rd edition in 2002 -- including new technologies like software-based recording systems such as Pro Tools and Sound Forge; digital recording using MP3, wave files and others; mobile audio devices such as iPods and MP3 players. Over 40 topic

  18. Induction machine handbook

    CERN Document Server

    Boldea, Ion

    2002-01-01

    Often called the workhorse of industry, the advent of power electronics and advances in digital control are transforming the induction motor into the racehorse of industrial motion control. Now, the classic texts on induction machines are nearly three decades old, while more recent books on electric motors lack the necessary depth and detail on induction machines.The Induction Machine Handbook fills industry's long-standing need for a comprehensive treatise embracing the many intricate facets of induction machine analysis and design. Moving gradually from simple to complex and from standard to

  19. Handbook of enumerative combinatorics

    CERN Document Server

    Bona, Miklos

    2015-01-01

    Presenting the state of the art, the Handbook of Enumerative Combinatorics brings together the work of today's most prominent researchers. The contributors survey the methods of combinatorial enumeration along with the most frequent applications of these methods.This important new work is edited by Miklós Bóna of the University of Florida where he is a member of the Academy of Distinguished Teaching Scholars. He received his Ph.D. in mathematics at Massachusetts Institute of Technology in 1997. Miklós is the author of four books and more than 65 research articles, including the award-winning C

  20. Handbook of graph theory

    CERN Document Server

    Gross, Jonathan L; Zhang, Ping

    2013-01-01

    In the ten years since the publication of the best-selling first edition, more than 1,000 graph theory papers have been published each year. Reflecting these advances, Handbook of Graph Theory, Second Edition provides comprehensive coverage of the main topics in pure and applied graph theory. This second edition-over 400 pages longer than its predecessor-incorporates 14 new sections. Each chapter includes lists of essential definitions and facts, accompanied by examples, tables, remarks, and, in some cases, conjectures and open problems. A bibliography at the end of each chapter provides an ex

  1. Heat exchanger design handbook

    CERN Document Server

    Thulukkanam, Kuppan

    2013-01-01

    Completely revised and updated to reflect current advances in heat exchanger technology, Heat Exchanger Design Handbook, Second Edition includes enhanced figures and thermal effectiveness charts, tables, new chapter, and additional topics--all while keeping the qualities that made the first edition a centerpiece of information for practicing engineers, research, engineers, academicians, designers, and manufacturers involved in heat exchange between two or more fluids.See What's New in the Second Edition: Updated information on pressure vessel codes, manufacturer's association standards A new c

  2. Centrifugal pump handbook

    CERN Document Server

    Pumps, Sulzer

    2010-01-01

    This long-awaited new edition is the complete reference for engineers and designers working on pump design and development or using centrifugal pumps in the field. This authoritative guide has been developed with access to the technical expertise of the leading centrifugal pump developer, Sulzer Pumps. In addition to providing the most comprehensive centrifugal pump theory and design reference with detailed material on cavitation, erosion, selection of materials, rotor vibration behavior and forces acting on pumps, the handbook also covers key pumping applications topics and operational

  3. Handbook of thermoluminescence

    CERN Document Server

    Furetta, Claudio

    2010-01-01

    This second edition of the Handbook of Thermoluminescence enlarges on all the subjects which were treated in the first edition and adds further arguments, including the theory of thermoluminescent dose measurement, several examples concerning the kinetics parameters determination using various methods such as peak shape, isothermal decay, and so on. A special section is devoted to food irradiation, an important subject at the present time, and to the thermoluminescent characterization of the minerals extracted from the irradiated food. Another new section is devoted to the thermoluminescent ph

  4. The image processing handbook

    CERN Document Server

    Russ, John C

    2006-01-01

    Now in its fifth edition, John C. Russ's monumental image processing reference is an even more complete, modern, and hands-on tool than ever before. The Image Processing Handbook, Fifth Edition is fully updated and expanded to reflect the latest developments in the field. Written by an expert with unequalled experience and authority, it offers clear guidance on how to create, select, and use the most appropriate algorithms for a specific application. What's new in the Fifth Edition? ·       A new chapter on the human visual process that explains which visual cues elicit a response from the vie

  5. Industrial communication technology handbook

    CERN Document Server

    Zurawski, Richard

    2005-01-01

    The Industrial Communication Technology Handbook focuses on current and newly emerging communication technologies and systems that are evolving in response to the needs of industry and the demands of industry-led consortia and organizations.Organized into two parts, the text first summarizes the basics of data communications and IP networks, then presents a comprehensive overview of the field of industrial communications. This book extensively covers the areas of fieldbus technology, industrial Ethernet and real-time extensions, wireless and mobile technologies in industrial applications, the

  6. Handbook of purified gases

    CERN Document Server

    Schoen, Helmut

    2015-01-01

    Technical gases are used in almost every field of industry, science and medicine and also as a means of control by government authorities and institutions and are regarded as indispensable means of assistance. In this complete handbook of purified gases the physical foundations of purified gases and mixtures as well as their manufacturing, purification, analysis, storage, handling and transport are presented in a comprehensive way. This important reference work is accompanied with a large number of Data Sheets dedicated to the most important purified gases.  

  7. Handbook of electromagnetic compatibility

    CERN Document Server

    1995-01-01

    This""know-how""book gives readers a concise understanding of the fundamentals of EMC, from basic mathematical and physical concepts through present, computer-age methods used in analysis, design, and tests. With contributions from leading experts in their fields, the text provides a comprehensive overview. Fortified with information on how to solve potential electromagnetic interference (EMI) problems that may arise in electronic design, practitioners will be betterable to grasp the latest techniques, trends, and applications of this increasingly important engineering discipline.Handbook of E

  8. Mechanical design engineering handbook

    CERN Document Server

    Childs, Peter R N

    2013-01-01

    Mechanical Design Engineering Handbook is a straight-talking and forward-thinking reference covering the design, specification, selection, use and integration of machine elements fundamental to a wide range of engineering applications. Develop or refresh your mechanical design skills in the areas of bearings, shafts, gears, seals, belts and chains, clutches and brakes, springs, fasteners, pneumatics and hydraulics, amongst other core mechanical elements, and dip in for principles, data and calculations as needed to inform and evaluate your on-the-job decisions. Covering the full spectrum

  9. Handbook of compliant mechanisms

    CERN Document Server

    Howell, Larry L; Olsen, Brian M

    2013-01-01

    A fully illustrated reference book giving an easy-to-understand introduction to compliant mechanisms A broad compilation of compliant mechanisms to give inspiration and guidance to those interested in using compliant mechanisms in their designs, the Handbook of Compliant Mechanisms includes graphics and descriptions of many compliant mechanisms. It comprises an extensive categorization of devices that can be used to help readers identify compliant mechanisms related to their application. It also provides chapters on the basic background in compliant mechanisms, the categories o

  10. Near field communications handbook

    CERN Document Server

    Ahson, Syed A; Furht, Borko

    2011-01-01

    Near Field Communication, or NFC, is a short-range high frequency wireless communication technology that enables the exchange of data between devices over about a decimeter. The technology is a simple extension of the ISO 14443 proximity-card standard (contact less card, RFID) that combines the interface of a smart card and a reader into a single device with practical implications. A complete reference for NFC, this handbook provides technical information about all aspects of NFC, as well as applications. It covers basic concepts as well as research grade material and includes a discussion of

  11. Handbook of algebra

    CERN Document Server

    Hazewinkel, M

    2008-01-01

    Algebra, as we know it today, consists of many different ideas, concepts and results. A reasonable estimate of the number of these different items would be somewhere between 50,000 and 200,000. Many of these have been named and many more could (and perhaps should) have a name or a convenient designation. Even the nonspecialist is likely to encounter most of these, either somewhere in the literature, disguised as a definition or a theorem or to hear about them and feel the need for more information. If this happens, one should be able to find enough information in this Handbook to judge if it i

  12. Handbook of reference electrodes

    CERN Document Server

    Inzelt, György; Scholz, Fritz

    2013-01-01

    Reference Electrodes are a crucial part of any electrochemical system, yet an up-to-date and comprehensive handbook is long overdue. Here, an experienced team of electrochemists provides an in-depth source of information and data for the proper choice and construction of reference electrodes. This includes all kinds of applications such as aqueous and non-aqueous solutions, ionic liquids, glass melts, solid electrolyte systems, and membrane electrodes. Advanced technologies such as miniaturized, conducting-polymer-based, screen-printed or disposable reference electrodes are also covered. Essen

  13. Electric motor handbook

    CERN Document Server

    Chalmers, B J

    2013-01-01

    Electric Motor Handbook aims to give practical knowledge in a wide range of capacities such as plant design, equipment specification, commissioning, operation and maintenance. The book covers topics such as the modeling of steady-state motor performance; polyphase induction, synchronous, and a.c. commutator motors; ambient conditions, enclosures, cooling and loss dissipation; and electrical supply systems and motor drives. Also covered are topics such as variable-speed drives and motor control; materials and motor components; insulation types, systems, and techniques; and the installation, sit

  14. CRC handbook of modern telecommunications

    CERN Document Server

    Morreale, Patricia A

    2001-01-01

    This authoritative handbook, contributed to by a team of international experts, covers the most dynamic areas in the changing telecommunications landscape. Written for telecommunications specialists who implement the new technologies, The CRC Handbook of Modern Telecommunications is an excellent companion volume to the authors' The Telecommunications Handbook, but stands well on its own, as it extends the range of topics to include voice over Internet, traffic management, quality of service, and other dominant future trends. It is an indispensable reference for all professionals working in the

  15. Gro2mat: a package to efficiently read gromacs output in MATLAB.

    Science.gov (United States)

    Dien, Hung; Deane, Charlotte M; Knapp, Bernhard

    2014-07-30

    Molecular dynamics (MD) simulations are a state-of-the-art computational method used to investigate molecular interactions at atomic scale. Interaction processes out of experimental reach can be monitored using MD software, such as Gromacs. Here, we present the gro2mat package that allows fast and easy access to Gromacs output files from Matlab. Gro2mat enables direct parsing of the most common Gromacs output formats including the binary xtc-format. No openly available Matlab parser currently exists for this format. The xtc reader is orders of magnitudes faster than other available pdb/ascii workarounds. Gro2mat is especially useful for scientists with an interest in quick prototyping of new mathematical and statistical approaches for Gromacs trajectory analyses. © 2014 Wiley Periodicals, Inc.

  16. Handbook of ecotoxicology

    Science.gov (United States)

    Hoffman, David J.; Rattner, Barnett A.; Burton, G. Allen; Cairns, John

    1995-01-01

    The Handbook of Ecotoxicology offers 34 chapters with contributions from over 50 selected international experts. The book is divided into four major sections: I. Quantifying and Measuring Ecotoxicological Effects, II. Contaminant Sources and Effects, III. Case Histories and Ecosystem Surveys, and IV. Methods for Making Estimates and Predictability in Ecotoxicology. Concepts and methodology are presented for many types of aquatic and terrestrial ecotoxicity test protocols for both controlled and field assessments. Chapters are offered on such diverse topics as sediment and soil ecotoxicity, landscape indicators, biomonitoring, and use of current bioindicators. The roles of deforestation and global warming, pathogens and disease in ecotoxicology, abiotic factors, urban runoff, predictive ecotoxicology, population modeling, and restoration ecology are discussed. This book was designed to serve as a reference book for students entering the fields of ecotoxicology, aquatic toxicology, terrestrial wildlife toxicology, and other environmental sciences. Many portions of this handbook will serve as a convenient reference text for established investigators, resource managers, and those involved in risk assessment and risk management within regulatory agencies and the private sector.

  17. Photovoltaic Incentive Design Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Hoff, T. E.

    2006-12-01

    Investments in customer-owned grid-connected photovoltaic (PV) energy systems are growing at a steady pace. This is due, in part, to the availability of attractive economic incentives offered by public state agencies and utilities. In the United States, these incentives have largely been upfront lump payments tied to the system capacity rating. While capacity-based ''buydowns'' have stimulated the domestic PV market, they have been criticized for subsidizing systems with potentially poor energy performance. As a result, the industry has been forced to consider alternative incentive structures, particularly ones that pay based on long-term measured performance. The industry, however, lacks consensus in the debate over the tradeoffs between upfront incentive payments versus longer-term payments for energy delivery. This handbook is designed for agencies and utilities that offer or intend to offer incentive programs for customer-owned PV systems. Its purpose is to help select, design, and implement incentive programs that best meet programmatic goals. The handbook begins with a discussion of the various available incentive structures and then provides qualitative and quantitative tools necessary to design the most appropriate incentive structure. It concludes with program administration considerations.

  18. Handbook of mass measurement

    CERN Document Server

    Jones, Frank E

    2002-01-01

    "How much does it weigh?" seems a simple question. To scientists and engineers, however, the answer is far from simple, and determining the answer demands consideration of an almost overwhelming number of factors.With an intriguing blend of history, fundamentals, and technical details, the Handbook of Mass Measurement sets forth the details of achieving the highest precision in mass measurements. It covers the whole field, from the development, calibration, and maintenance of mass standards to detailed accounts of weighing designs, balances, and uncertainty. It addresses the entire measurement process and provides in-depth examinations of the various factors that introduce error.Much of the material is the authors'' own work and some of it is published here for the first time. Jones and Schoonover are both highly regarded veterans of the U.S. National Institute of Standards and Technology. With this handbook, they have provided a service and resource vital to anyone involved not only in the determination of m...

  19. Análise funcional das proteínas HrcA, GroES/GroEL e DnaK/DnaJ em Caulobacter crescentus

    OpenAIRE

    Michelle Fernanda Susin

    2005-01-01

    O operon groESL de C. crescentus apresenta dupla regulação. A indução deste operon por choque térmico é dependente do fator sigma de choque térmico σ32. A temperaturas fisiológicas, a expressão de groESL apresenta regulação temporal durante o ciclo celular da bactéria e o controle envolve a proteína repressora HrcA e o elemento CIRCE (controlling inverted repeat of chaperonin expression). Para estudar a atividade da proteína repressora in vitro, produzimos e purificamos de E. coli a Hrc...

  20. Developer's handbook of interactive multimedia

    CERN Document Server

    Phillips, Robin

    2014-01-01

    New technology is being used more and more in education and providers have to be aware of what is on offer and how it can be used. This practical handbook demonstrates how interactive multimedia can be developed for educational application.

  1. Handbook of unmanned aerial vehicles

    CERN Document Server

    Vachtsevanos, George

    2015-01-01

    The Handbook of Unmanned Aerial Vehicles is a reference text for the academic and research communities, industry, manufacturers, users, practitioners, Federal Government, Federal and State Agencies, the private sector, as well as all organizations that are and will be using unmanned aircraft in a wide spectrum of applications. The Handbook covers all aspects of UAVs, from design to logistics and ethical issues. It is also targeting the young investigator, the future inventor and entrepreneur by providing an overview and detailed information of the state-of-the-art as well as useful new concepts that may lead to innovative research. The contents of the Handbook include material that addresses the needs and ‘know how’ of all of the above sectors targeting a very diverse audience. The Handbook offers a unique and comprehensive treatise of everything one needs to know about unmanned aircrafts, from conception to operation, from technologies to business activities, users, OEMs, reference sources, conferences, ...

  2. Hanford Facility RCRA permit handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Purpose of this Hanford Facility (HF) RCRA Permit Handbook is to provide, in one document, information to be used for clarification of permit conditions and guidance for implementing the HF RCRA Permit.

  3. Urban Farm Business Plan Handbook

    Science.gov (United States)

    The Urban Farm Business Plan Handbook (this document) provides guidance for developing a business plan for the startup and operation of an urban farm. It focuses on food and non-food related cultivated agriculture.

  4. Wind energy a reference handbook

    CERN Document Server

    Newton, PhD, David E

    2014-01-01

    While covering the fascinating history of wind power as a whole, this timely handbook focuses on current technological developments and the promise--and pitfalls--of wind energy as part of the world's energy future.

  5. Stereoscopic observations of hard x ray sources in solar flares made with GRO and other spacecraft

    Science.gov (United States)

    Kane, S. R.; Hurley, K.; Mctiernan, J. M.; Laros, J. G.

    1992-01-01

    Since the launch of the Gamma Ray Observatory (GRO) in Apr. 1991, the Burst and Transient Source Experiment (BATSE) instrument on GRO has recorded a large number of solar flares. Some of these flares have also been observed by the Gamma-Ray Burst Detector on the Pioneer Venus Orbiter (PVO) and/or by the Solar X-Ray/Cosmic Gamma-Ray Burst Experiment on the Ulysses spacecraft. A preliminary list of common flares observed during the period May-Jun. 1991 is presented and the possible joint studies are indicated.

  6. Bibliothekarische Berufsethik in der Praxis – Ergebnisse eines Studienprojekts aus Deutschland und Großbritannien

    Directory of Open Access Journals (Sweden)

    Jens Boye

    2011-10-01

    Full Text Available Sowohl in Deutschland als auch in Großbritannien existieren seit einigen Jahren Grundsatzpapiere zur Berufsethik im Informations- und Bibliotheksbereich. Neben der bloßen Existenz derartiger Kodizes stellt sich die Frage, welche Relevanz diese Dokumente in der beruflichen Praxis haben. Dieser Frage wurde im Rahmen einer Team-Projektarbeit an der FH Köln nachgegangen. Mithilfe eines standardisierten Fragebogens wurden deutsche Bibliotheksleitungen zu der Thematik befragt. In Großbritannien wurde ein Interview mit Paul Sturges geführt, darüber hinaus erfolgte eine Analyse der Online-Angebote von CILIP, insbesondere des Information Ethics Blog.

  7. A Handbook for Strategic Planning

    Science.gov (United States)

    1994-01-01

    This handbook was written for Department of the Navy (DON) commanding officers, TQL coordinators, and strategic planning facilitators in response to...questions about the strategic planning process and how it should be conducted within the DON. It is not intended to teach the intricacies of strategic ... planning , but is provided to answer process questions. While every question cannot be anticipated, the handbook details one way to do strategic

  8. Handbook of signal processing systems

    CERN Document Server

    Deprettere, Ed; Leupers, Rainer; Takala, Jarmo

    2013-01-01

    Handbook of Signal Processing Systems is organized in three parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools, describes models of computation and their associated design tools and methodologies. This handbook is an essential tool for professionals in many fields and researchers of all levels.

  9. The handbook of artificial intelligence

    CERN Document Server

    Barr, Avron J

    1981-01-01

    The Handbook of Artificial Intelligence, Volume I focuses on the progress in artificial intelligence (AI) and its increasing applications, including parsing, grammars, and search methods.The book first elaborates on AI, AI handbook and literature, problem representation, search methods, and sample search programs. The text then ponders on representation of knowledge, including survey of representation techniques and representation schemes. The manuscript explores understanding natural languages, as well as machine translation, grammars, parsing, test generation, and natural language processing

  10. Revising Academic Library Governance Handbooks

    Directory of Open Access Journals (Sweden)

    Jen Stevens

    2015-07-01

    Full Text Available Original Image by Flickr user Sasquatch 1 (CC BY 2.0, with minimal modification by C. Strunk (10 June 2015. In Brief Regardless of our status (tenure track, non-tenure track, staff, and/or union, academic librarians at colleges and universities may use a handbook or similar document as a framework for self-governance. These handbooks typically cover rank […

  11. Theories of Specialized Discourses and Writing Fellows Programs

    Science.gov (United States)

    Severino, Carol; Trachsel, Mary

    2008-01-01

    How much do specialized academic discourse communities matter to undergraduate writers? To what degree should theories of specialized discourses influence the design of undergraduate Writing Across the Curriculum (WAC) programs? At the University of Iowa, where an undergraduate Writing Fellows program engages peer tutors in writing-intensive…

  12. Practicing Statistics by Creating Exercises for Fellow Students

    Science.gov (United States)

    Bebermeier, Sarah; Reiss, Katharina

    2016-01-01

    This article outlines the execution of a workshop in which students were encouraged to actively review the course contents on descriptive statistics by creating exercises for their fellow students. In a first-year statistics course in psychology, 39 out of 155 students participated in the workshop. In a subsequent evaluation, the workshop was…

  13. Former Nonproliferation Graduate Fellow Served at U.S. Mission

    Energy Technology Data Exchange (ETDEWEB)

    Brim, Cornelia P.

    2014-10-01

    Because of her training and professional experiences, Rosalyn Leitch, a Security Specialist at Pacific Northwest National Laboratory and former Nonproliferation Graduate Fellow with NIS (2012-2013) was able to transition into temporary assignment as UNVIE Acting Nuclear Security Attaché from November 2013 through February 2014.

  14. Physics GRE Scores of Prize Postdoctoral Fellows in Astronomy

    Science.gov (United States)

    Levesque, Emily M.; Bezanson, Rachel; Tremblay, Grant

    2017-01-01

    The Physics GRE has long been a required element of the graduate admissions process in many U.S. astronomy programs; however, its predictive power and utility as a means of selection "successful" applicants had not been quantitatively examined until recently. In the fall of 2015 we circulated a short questionnaire to 271 people who have held U.S. prize postdoctoral fellowships in astrophysics between 2010-2015, asking them to report their Physics GRE scores. The response rate was 64%, and the responding sample was unbiased with respect to the overall gender distribution of prize fellows. The responses revealed that the Physics GRE scores of prize fellows do not adhere to any minimum percentile score and show no statistically significant correlation with the number of first author papers published. As an example, a Physics GRE percentile cutoff of 60% would have eliminated 44% of 2010-2015 U.S. prize postdoctoral fellows, including 60% of the female fellows. From these data, we found no evidence that the Physics GRE could be used as an effective predictor of "success" either in or beyond graduate school. Following this work and last year's official recommendation from the AAS, several astronomy departments have recently decided to eliminate the Physics GRE as a requirement for graduate applicants.

  15. 34 CFR 1100.20 - How is a fellow selected?

    Science.gov (United States)

    2010-07-01

    ... LITERACY NATIONAL INSTITUTE FOR LITERACY: LITERACY LEADER FELLOWSHIP PROGRAM How Does the Director Award a Fellowship? § 1100.20 How is a fellow selected? (a) The Director selects applications for fellowships on the... Register and are applicable to the selection of applications. (b)(1) The Director may use experts from the...

  16. The Advanced Technology Environmental Education Center Summer Fellows Institute.

    Science.gov (United States)

    Depken, Diane E.; Zeman, Catherine L.; Lensch, Ellen Kabat; Brown, Edward J.

    2002-01-01

    Describes the background, activities, and outcomes of the Advanced Technology Environmental Education Center (ATEEC) and its Summer Fellows Institutes as a model for disciplinary and cross-disciplinary infusion of environmental science and technology content, curriculum, and methods into the classroom. Presents experiences, themes, and activities…

  17. 77 FR 61791 - System of Records; Presidential Management Fellows Program

    Science.gov (United States)

    2012-10-11

    ... Personnel Management Human Resource Solutions will now be collected by a contractor. A routine use was added... existing OPM Human Resource Services (HRS) operated system in Macon, GA will continue to function in... MANAGEMENT System of Records; Presidential Management Fellows Program AGENCY: U.S. Office of Personnel...

  18. Why is Danish so difficult to understand for fellow Scandinavians?

    NARCIS (Netherlands)

    Schüppert, Anja; Hilton, Nanna; Gooskens, Charlotte

    2016-01-01

    It has consistently been shown that among the three mainland Scandinavian languages, Danish is most difficult to understand for fellow Scandinavians. Recent research suggests that Danish is spoken significantly faster than Norwegian and Swedish. This finding might partly explain the asymmetric intel

  19. Communication skills training curriculum for pulmonary and critical care fellows.

    Science.gov (United States)

    McCallister, Jennifer W; Gustin, Jillian L; Wells-Di Gregorio, Sharla; Way, David P; Mastronarde, John G

    2015-04-01

    The Accreditation Council for Graduate Medical Education requires physicians training in pulmonary and critical care medicine to demonstrate competency in interpersonal communication. Studies have shown that residency training is often insufficient to prepare physicians to provide end-of-life care and facilitate patient and family decision-making. Poor communication in the intensive care unit (ICU) can adversely affect outcomes for critically ill patients and their family members. Despite this, communication training curricula in pulmonary and critical care medicine are largely absent in the published literature. We evaluated the effectiveness of a communication skills curriculum during the first year of a pulmonary and critical care medicine fellowship using a family meeting checklist to provide formative feedback to fellows during ICU rotations. We hypothesized that fellows would demonstrate increased competence and confidence in the behavioral skills necessary for facilitating family meetings. We evaluated a 12-month communication skills curriculum using a pre-post, quasiexperimental design. Subjects for this study included 11 first-year fellows who participated in the new curriculum (intervention group) and a historical control group of five fellows who had completed no formal communication curriculum. Performance of communication skills and self-confidence in family meetings were assessed for the intervention group before and after the curriculum. The control group was assessed once at the beginning of their second year of fellowship. Fellows in the intervention group demonstrated significantly improved communication skills as evaluated by two psychologists using the Family Meeting Behavioral Skills Checklist, with an increase in total observed skills from 51 to 65% (P ≤ 0.01; Cohen's D effect size [es], 1.13). Their performance was also rated significantly higher when compared with the historical control group, who demonstrated only 49% of observed skills

  20. EURANOS. The Handbook Users Group (HUG)

    DEFF Research Database (Denmark)

    Nisbet, A.F.; Andersson, Kasper Grann; Carlé, B.;

    the demonstrations were discussed with the HUG steering group who then made recommendations to the handbook developers on how the handbooks could be improved in the future. Updates have been made and version 2 of the generic handbooks will be published in 2009. In the future, it is likely that the HUG will join......Three handbooks to assist in the management of contaminated food production systems, inhabited areas and drinking water supplies have been developed in conjunction with a wide range of stakeholders in Europe. These handbooks are living documents that will require updating from time to time...... to remain state-of-the-art. To address this need, a handbook users’ group (HUG) was established in 2007 to provide a platform for maintaining the handbooks and to build a network of users for both the generic handbooks and any subsequently customised versions. A web site was set up (www...

  1. How To Develop Survey Protocols: A Handbook

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This handbook provides a standard and guidance for developing and reviewing survey protocols used in the National Wildlife Refuge System. In the handbook, survey...

  2. Society News: RAS Fellows are honoured with awards; Patrick Moore Medal; Best theses win prizes; New Fellows

    Science.gov (United States)

    2011-08-01

    Congratulations to several Fellows of the RAS who have received prestigious awards this year. Congratulations to the winners of the annual prizes for the best PhD theses in astronomy and geophysics, awarded by the RAS and sponsored by Wiley-Blackwell. Winners receive a cheque for £1000, runners-up £50.

  3. Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats.

    Directory of Open Access Journals (Sweden)

    Feng-Yen Lin

    Full Text Available Porphyromonas gingivalis is a major periodontal pathogen that contains a variety of virulence factors. The antibody titer to P. gingivalis GroEL, a homologue of HSP60, is significantly higher in periodontitis patients than in healthy control subjects, suggesting that P. gingivalis GroEL is a potential stimulator of periodontal disease. However, the specific role of GroEL in periodontal disease remains unclear. Here, we investigated the effect of P. gingivalis GroEL on human periodontal ligament (PDL cells in vitro, as well as its effect on alveolar bone resorption in rats in vivo. First, we found that stimulation of PDL cells with recombinant GroEL increased the secretion of the bone resorption-associated cytokines interleukin (IL-6 and IL-8, potentially via NF-κB activation. Furthermore, GroEL could effectively stimulate PDL cell migration, possibly through activation of integrin α1 and α2 mRNA expression as well as cytoskeletal reorganization. Additionally, GroEL may be involved in osteoclastogenesis via receptor activator of nuclear factor κ-B ligand (RANKL activation and alkaline phosphatase (ALP mRNA inhibition in PDL cells. Finally, we inoculated GroEL into rat gingiva, and the results of microcomputed tomography (micro-CT and histomorphometric assays indicated that the administration of GroEL significantly increased inflammation and bone loss. In conclusion, P. gingivalis GroEL may act as a potent virulence factor, contributing to osteoclastogenesis of PDL cells and resulting in periodontal disease with alveolar bone resorption.

  4. GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function.

    Directory of Open Access Journals (Sweden)

    Yi-Wen Lin

    Full Text Available The number and function of endothelial progenitor cells (EPCs are sensitive to hyperglycemia, hypertension, and smoking in humans, which are also associated with the development of atherosclerosis. GroEL1 from Chlamydia pneumoniae has been found in atherosclerotic lesions and is related to atherosclerotic pathogenesis. However, the actual effects of GroEL1 on EPC function are unclear. In this study, we investigate the EPC function in GroEL1-administered hind limb-ischemic C57BL/B6 and C57BL/10ScNJ (a toll-like receptor 4 (TLR4 mutation mice and human EPCs. In mice, laser Doppler imaging, flow cytometry, and immunohistochemistry were used to evaluate the degree of neo-vasculogenesis, circulating level of EPCs, and expression of CD34, vWF, and endothelial nitric oxide synthase (eNOS in vessels. Blood flow in the ischemic limb was significantly impaired in C57BL/B6 but not C57BL/10ScNJ mice treated with GroEL1. Circulating EPCs were also decreased after GroEL1 administration in C57BL/B6 mice. Additionally, GroEL1 inhibited the expression of CD34 and eNOS in C57BL/B6 ischemic muscle. In vitro, GroEL1 impaired the capacity of differentiation, mobilization, tube formation, and migration of EPCs. GroEL1 increased senescence, which was mediated by caspases, p38 MAPK, and ERK1/2 signaling in EPCs. Furthermore, GroEL1 decreased integrin and E-selectin expression and induced inflammatory responses in EPCs. In conclusion, these findings suggest that TLR4 and impaired NO-related mechanisms could contribute to the reduced number and functional activity of EPCs in the presence of GroEL1 from C. pneumoniae.

  5. 20 CFR 638.501 - Student handbook.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Student handbook. 638.501 Section 638.501... TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.501 Student handbook. Each center operator shall develop a student handbook which provides essential information to students for distribution...

  6. Instrumentation Hardware Abstraction Language (IHAL) Handbook

    Science.gov (United States)

    2017-01-01

    Telemetry Group DOCUMENT 128-17 INSTRUMENTATION HARDWARE ABSTRACTION LANGUAGE (IHAL) HANDBOOK DISTRIBUTION A...intentionally left blank DOCUMENT 128-17 INSTRUMENTATION HARDWARE ABSTRACTION LANGUAGE (IHAL) HANDBOOK January 2017...5100 This page intentionally left blank. Instrumentation Hardware Abstract Language (IHAL) Handbook, RCC Document 128-17, January 2017 iii

  7. Site Development Planning Handbook

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-01

    The Handbook provides facility managers and site planners at DOE organizations responsible for planning site developments and facilities utilization a step-by-step planning checklist to ensure that planners at each site are focusing on Department-wide goals and objectives. It begins with a brief discussion of a site development-by-objectives program design to promote, recognize, and implement opportunities for improvements in site utilization through planning. Additional information is included on: assembling existing data, plans, programs, and procedures; establishing realistic objectives; identifying site problems, opportunities; and development needs; determining priorities among development needs; developing short and long-range plans; choosing the right development solutions and meeting minimum legal site restrictions; presenting the plan; implementing elements of the plan; monitoring and reporting plan status; and modifying development program plans. (MCW)

  8. Handbook of radioactivity analysis

    CERN Document Server

    2012-01-01

    The updated and much expanded Third Edition of the "Handbook of Radioactivity Analysis" is an authoritative reference providing the principles, practical techniques, and procedures for the accurate measurement of radioactivity from the very low levels encountered in the environment to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, fuel cycle facilities and in the implementation of nuclear forensic analysis and nuclear safeguards. The Third Edition contains seven new chapters providing a reference text much broader in scope than the previous Second Edition, and all of the other chapters have been updated and expanded many with new authors. The book describes the basic principles of radiation detection and measurement, the preparation of samples from a wide variety of matrices, assists the investigator or technician in the selection and use of appropriate radiation detectors, and presents state-of-the-ar...

  9. Handbook of Memetic Algorithms

    CERN Document Server

    Cotta, Carlos; Moscato, Pablo

    2012-01-01

    Memetic Algorithms (MAs) are computational intelligence structures combining multiple and various operators in order to address optimization problems.  The combination and interaction amongst operators evolves and promotes the diffusion of the most successful units and generates an algorithmic behavior which can handle complex objective functions and hard fitness landscapes.   “Handbook of Memetic Algorithms” organizes, in a structured way, all the the most important results in the field of MAs since their earliest definition until now.  A broad review including various algorithmic solutions as well as successful applications is included in this book. Each class of optimization problems, such as constrained optimization, multi-objective optimization, continuous vs combinatorial problems, uncertainties, are analysed separately and, for each problem,  memetic recipes for tackling the difficulties are given with some successful examples. Although this book contains chapters written by multiple authors, ...

  10. Handbook of geomathematics

    CERN Document Server

    Nashed, M; Sonar, Thomas

    2015-01-01

    During the last three decades geosciences and geo-engineering were influenced by two essential scenarios: First, the technological progress has changed completely the observational and measurement techniques. Modern high speed computers and satellite based techniques are entering more and more all geodisciplines. Second, there is a growing public concern about the future of our planet, its climate, its environment and about an expected shortage of natural resources. Obviously, both aspects, viz. efficient strategies of protection against threats of a changing Earth and the exceptional situation of getting terrestrial, airborne as well as space borne data of better and better quality explain the strong need of new mathematical structures, tools and methods. Mathematics concerned with geoscientific problems, i.e., Geomathematics, is becoming increasingly important. The ‘Handbook of Geomathematics’ deals with the qualitative and quantitative properties for the current and possible structures of the system Ea...

  11. Handbook of simulation optimization

    CERN Document Server

    Fu, Michael C

    2014-01-01

    The Handbook of Simulation Optimization presents an overview of the state of the art of simulation optimization, providing a survey of the most well-established approaches for optimizing stochastic simulation models and a sampling of recent research advances in theory and methodology. Leading contributors cover such topics as discrete optimization via simulation, ranking and selection, efficient simulation budget allocation, random search methods, response surface methodology, stochastic gradient estimation, stochastic approximation, sample average approximation, stochastic constraints, variance reduction techniques, model-based stochastic search methods and Markov decision processes. This single volume should serve as a reference for those already in the field and as a means for those new to the field for understanding and applying the main approaches. The intended audience includes researchers, practitioners and graduate students in the business/engineering fields of operations research, management science,...

  12. Machine Vision Handbook

    CERN Document Server

    2012-01-01

    The automation of visual inspection is becoming more and more important in modern industry as a consistent, reliable means of judging the quality of raw materials and manufactured goods . The Machine Vision Handbook  equips the reader with the practical details required to engineer integrated mechanical-optical-electronic-software systems. Machine vision is first set in the context of basic information on light, natural vision, colour sensing and optics. The physical apparatus required for mechanized image capture – lenses, cameras, scanners and light sources – are discussed followed by detailed treatment of various image-processing methods including an introduction to the QT image processing system. QT is unique to this book, and provides an example of a practical machine vision system along with extensive libraries of useful commands, functions and images which can be implemented by the reader. The main text of the book is completed by studies of a wide variety of applications of machine vision in insp...

  13. Handbook for Language Detectives

    DEFF Research Database (Denmark)

    Bryanne, Ulla; Bruntt, Karen Scheel Lassen

    Handbook for Language Detectives gives a thorough presentation of English grammar and discusses how to teach grammar. The book unveils to the readers, who will be working as grammar detectives, the fascinating world of language. It does not only deal with "traditional grammar" but also discusses...... what different grammatical structures mean (semantics) and how they influence the level of style (pragmatics). Grammar should not be taught as a separate discipline; it can and should be integrated in communicative language teaching. The book gives you innovative and valuable ideas of how this can...... be done. The book serves a double purpose: - English grammar and language usage at bachelor level from a functional linguistic point of view. - How to teach English grammar within a communicative approach. The book is mainly intended for Danish student teachers of English, but anyone else interested...

  14. Handbook on loss reserving

    CERN Document Server

    Schmidt, Klaus; Schnaus, Anja

    2016-01-01

    This handbook presents the basic aspects of actuarial loss reserving. Besides the traditional methods, it also includes a description of more recent ones and a discussion of certain problems occurring in actuarial practice, like inflation, scarce data, large claims, slow loss development, the use of market statistics, the need for simulation techniques and the task of calculating best estimates and ranges of future losses. In property and casualty insurance the provisions for payment obligations from losses that have occurred but have not yet been settled usually constitute the largest item on the liabilities side of an insurer's balance sheet. For this reason, the determination and evaluation of these loss reserves is of considerable economic importance for every property and casualty insurer. Actuarial students, academics as well as practicing actuaries will benefit from this overview of the most important actuarial methods of loss reserving by developing an understanding of the underlying stochastic models...

  15. Handbook of mathematics

    CERN Document Server

    Bronshtein, I N; Musiol, Gerhard; Mühlig, Heiner

    2015-01-01

    This guide book to mathematics contains in handbook form the fundamental working knowledge of mathematics which is needed as an everyday guide for working scientists and engineers, as well as for students. Easy to understand, and convenient to use, this guide book gives concisely the information necessary to evaluate most problems which occur in concrete applications. In the newer editions emphasis was laid on those fields of mathematics that became more important for the formulation and modeling of technical and natural processes, namely Numerical Mathematics, Probability Theory and Statistics, as well as Information Processing. Besides many enhancements and  new paragraphs,  new sections on Geometric and Coordinate Transformations, Quaternions and Applications, and Lie Groups and Lie Algebras were added for the sixth edition.

  16. Solar cell radiation handbook

    Science.gov (United States)

    Tada, H. Y.; Carter, J. R., Jr.; Anspaugh, B. E.; Downing, R. G.

    1982-01-01

    The handbook to predict the degradation of solar cell electrical performance in any given space radiation environment is presented. Solar cell theory, cell manufacturing and how they are modeled mathematically are described. The interaction of energetic charged particles radiation with solar cells is discussed and the concept of 1 MeV equivalent electron fluence is introduced. The space radiation environment is described and methods of calculating equivalent fluences for the space environment are developed. A computer program was written to perform the equivalent fluence calculations and a FORTRAN listing of the program is included. Data detailing the degradation of solar cell electrical parameters as a function of 1 MeV electron fluence are presented.

  17. Welding processes handbook

    CERN Document Server

    Weman, Klas

    2011-01-01

    Offers an introduction to the range of available welding technologies. This title includes chapters on individual techniques that cover principles, equipment, consumables and key quality issues. It includes material on such topics as the basics of electricity in welding, arc physics, and distortion, and the weldability of particular metals.$bThe first edition of Welding processes handbook established itself as a standard introduction and guide to the main welding technologies and their applications. This new edition has been substantially revised and extended to reflect the latest developments. After an initial introduction, the book first reviews gas welding before discussing the fundamentals of arc welding, including arc physics and power sources. It then discusses the range of arc welding techniques including TIG, plasma, MIG/MAG, MMA and submerged arc welding. Further chapters cover a range of other important welding technologies such as resistance and laser welding, as well as the use of welding techniqu...

  18. The photomultiplier handbook

    CERN Document Server

    Wright, A G

    2017-01-01

    Photomultipliers are extremely sensitive light detectors that can detect single photons. In multiplying the charge produced by incident light by up to 100 million times, these devices are essential to a wide range of functions, from medical instrumentation to astronomical observations. This complete and authoritative guide will provide students, practitioners, and researchers with a deeper understanding of the operating principles of these devices. Authored by an experienced user and manufacturer of photomultipliers, this handbook gives the reader insights into photomultiplier behaviour as a means to optimize performance. Diffuse and low level light sources are best served with a photomultiplier for the detection of single photon emissions. Light detection and electron multiplication are statistical in nature and the mathematics of these processes is derived from first principles. The book covers other related topics such as scintillation counting, light guides, and large area detectors. The usually complicat...

  19. Handbook of Intelligent Vehicles

    CERN Document Server

    2012-01-01

    The Handbook of Intelligent Vehicles provides a complete coverage of the fundamentals, new technologies, and sub-areas essential to the development of intelligent vehicles; it also includes advances made to date, challenges, and future trends. Significant strides in the field have been made to date; however, so far there has been no single book or volume which captures these advances in a comprehensive format, addressing all essential components and subspecialties of intelligent vehicles, as this book does. Since the intended users are engineering practitioners, as well as researchers and graduate students, the book chapters do not only cover fundamentals, methods, and algorithms but also include how software/hardware are implemented, and demonstrate the advances along with their present challenges. Research at both component and systems levels are required to advance the functionality of intelligent vehicles. This volume covers both of these aspects in addition to the fundamentals listed above.

  20. Further observations of GRO J1750-27 (AXJ1749.1-2639) with INTEGRAL

    DEFF Research Database (Denmark)

    Brandt, Søren Kristian; Shaw, S.; Hill, A.;

    2008-01-01

    The transient accreting X-ray pulsar GRO J1750-27 (AX J1749.1-2639), which became active end of January 2008 (ATel #1376), has been repeatedly observed by the INTEGRAL Galactic Bulge monitoring program since mid February (ATel #1385) on 11, 20 and 23 Feb. 2008. During the three observations...

  1. Rapidly evolving circularly polarized emission during the 1994 outburst of GRO J1655-40

    NARCIS (Netherlands)

    Macquart, JP; Wu, K; Sault, RJ; Hannikainen, DC

    2002-01-01

    We report the detection of circular polarization during the 1994 outburst of the Galactic microquasar GRO J1655-40. The circular polarization is clearly detected at 1.4 and 2.4 GHz, but not at 4.8 and 8.4 GHz, where its magnitude never exceeds 5 mJy. Both the sign and magnitude of the circular

  2. Positive selection in the leucine-rich repeat domain of Gro1 genes in Solanum species

    Indian Academy of Sciences (India)

    Valentino Ruggieri; Angelina Nunziata; Amalia Barone

    2014-12-01

    In pathogen resistant plants, solvent-exposed residues in the leucine-rich repeat (LRR) proteins are thought to mediate resistance by recognizing plant pathogen elicitors. In potato, the gene Gro1-4 confers resistance to Globodera rostochiensis. The investigation of variablity in different copies of this gene represents a good model for the verification of positive selection mechanisms. Two datasets of Gro1 LRR sequences were constructed, one derived from the Gro1-4 gene, belonging to different cultivated and wild Solanum species, and the other belonging to paralogues of a resistant genotype. Analysis of non-synonymous to synonymous substitution rates $(K_{a}/K_{s})$ highlighted 14 and six amino acids with $K_{a}/K_{s} \\gt 1$ in orthologue and paralogue datasets, respectively. Selection analysis revealed that the leucine-rich regions accumulate variability in a very specific way, and we found that some combinations of amino acids in these sites might be involved in pathogen recognition. The results confirm previous studies on positive selection in the LRR domain of R protein in Arabidopsis and other model plants and extend these to wild Solanum species. Moreover, positively selected sites in the Gro1 LRR domain show that coevolution mainly occurred in two regions on the internal surface of the three-dimensional horseshoe structure of the domain, albeit with different evolutionary forces between paralogues and orthologues.

  3. The Accretion Powered Spin-up of GRO 1750–27

    DEFF Research Database (Denmark)

    Kretschmar, P.; Shaw, S.; Hill, A. B.

    2009-01-01

    The transient Be X-ray pulsar GRO J1750-27 was originally detected in 1995 by CGRO/BATSE during a giant outburst. After a long period of quiescence the source was detected in another outburst early 2008. Following this outburst with hard X-ray data from INTEGRAL and Swift, the orbital parameters ...

  4. The accretion powered spin-up of GRO J1750-27

    DEFF Research Database (Denmark)

    Shaw, S.E.; Hill, A.B.; Kuulkers, E.

    2009-01-01

    ), respectively. The model is then used to compare the time-resolved variation of the X-ray flux and intrinsic spin-up against the accretion torque model of Ghosh & Lamb; this finds that GRO J1750-27 is likely located 12-22 kpc distant and that the surface magnetic field of the neutron star is similar to 2 x 10...

  5. Computational Approaches for Mining GRO-Seq Data to Identify and Characterize Active Enhancers.

    Science.gov (United States)

    Nagari, Anusha; Murakami, Shino; Malladi, Venkat S; Kraus, W Lee

    2017-01-01

    Transcriptional enhancers are DNA regulatory elements that are bound by transcription factors and act to positively regulate the expression of nearby or distally located target genes. Enhancers have many features that have been discovered using genomic analyses. Recent studies have shown that active enhancers recruit RNA polymerase II (Pol II) and are transcribed, producing enhancer RNAs (eRNAs). GRO-seq, a method for identifying the location and orientation of all actively transcribing RNA polymerases across the genome, is a powerful approach for monitoring nascent enhancer transcription. Furthermore, the unique pattern of enhancer transcription can be used to identify enhancers in the absence of any information about the underlying transcription factors. Here, we describe the computational approaches required to identify and analyze active enhancers using GRO-seq data, including data pre-processing, alignment, and transcript calling. In addition, we describe protocols and computational pipelines for mining GRO-seq data to identify active enhancers, as well as known transcription factor binding sites that are transcribed. Furthermore, we discuss approaches for integrating GRO-seq-based enhancer data with other genomic data, including target gene expression and function. Finally, we describe molecular biology assays that can be used to confirm and explore further the function of enhancers that have been identified using genomic assays. Together, these approaches should allow the user to identify and explore the features and biological functions of new cell type-specific enhancers.

  6. NASA Schedule Management Handbook

    Science.gov (United States)

    2011-01-01

    The purpose of schedule management is to provide the framework for time-phasing, resource planning, coordination, and communicating the necessary tasks within a work effort. The intent is to improve schedule management by providing recommended concepts, processes, and techniques used within the Agency and private industry. The intended function of this handbook is two-fold: first, to provide guidance for meeting the scheduling requirements contained in NPR 7120.5, NASA Space Flight Program and Project Management Requirements, NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Requirements, NPR 7120.8, NASA Research and Technology Program and Project Management Requirements, and NPD 1000.5, Policy for NASA Acquisition. The second function is to describe the schedule management approach and the recommended best practices for carrying out this project control function. With regards to the above project management requirements documents, it should be noted that those space flight projects previously established and approved under the guidance of prior versions of NPR 7120.5 will continue to comply with those requirements until project completion has been achieved. This handbook will be updated as needed, to enhance efficient and effective schedule management across the Agency. It is acknowledged that most, if not all, external organizations participating in NASA programs/projects will have their own internal schedule management documents. Issues that arise from conflicting schedule guidance will be resolved on a case by case basis as contracts and partnering relationships are established. It is also acknowledged and understood that all projects are not the same and may require different levels of schedule visibility, scrutiny and control. Project type, value, and complexity are factors that typically dictate which schedule management practices should be employed.

  7. Fellow eye treatment in excimer photo refractive keratectomy

    Directory of Open Access Journals (Sweden)

    Rao Srinivas

    2000-01-01

    Full Text Available Purpose: To describe symmetry of response in fellow eyes of patients undergoing photorefractive keratectomy (PRK for myopia, analyse the risk factors leading to asymmetry in response and to determine if delayed treatment of the second eye increases safety and predictability of PRK. Methods: Retrospective review of case records of 133 patients who underwent bilateral myopic PRK and had a minimum follow up of 6 months in both eyes. Results: Postoperative uncorrected visual acuity, spherical equivalent (SE refraction within ±1D of emmetropia, best-corrected visual acuity (BCVA and corneal haze were not significantly different in fellow eyes of patients undergoing PRK for myopia. Of 87 eyes in group 1 (myopia <6D, 96.6% had uncorrected visual acuity ≥6/ 12, 89.7% were within ±1D of emmetropia, none lost ≥1 line BCVA, and none had haze ≥grade 3. Similar results for 98 eyes in group II (myopia 6 to 9.9D were 75.6%, 55.1%, 2.0% and 2.0% respectively. For 81 eyes in group III (myopia ≥ 10D the results were 42.7%, 33.3%, 8.6%, and 4.9% respectively. Among 84 patients with similar preoperative myopia in both eyes, 54 (64.3% patients had a postoperative SE difference ≤ ID in fellow eyes. Risk factors for asymmetric response among fellow eyes included increasing preoperative myopia (p<0.001 and dissimilar treatment technique in the two eyes (p=0.03. Corneal haze did not increase significantly after the third postoperative month. Conclusion: This study demonstrates that considerable symmetry of response exists in fellow eyes of patients undergoing myopic PRK. Early PRK in the fellow eye of patients with < 6 D myopia is safe and allows quick visual rehabilitation of the patient. In patients with myopia ≥6D, a 3-month interval before treating the second eye may improve the safety of the procedure.

  8. Over expression of GroESL in Cupriavidus necator for heterotrophic and autotrophic isopropanol production.

    Science.gov (United States)

    Marc, Jillian; Grousseau, Estelle; Lombard, Eric; Sinskey, Anthony J; Gorret, Nathalie; Guillouet, Stéphane E

    2017-07-01

    We previously reported a metabolic engineering strategy to develop an isopropanol producing strain of Cupriavidus necator leading to production of 3.4gL(-1) isopropanol. In order to reach higher titers, isopropanol toxicity to the cells has to be considered. A toxic effect of isopropanol on the growth of C. necator has been indeed observed above a critical value of 15gL(-1). GroESL chaperones were first searched and identified in the genome of C. necator. Native groEL and groES genes from C. necator were over-expressed in a strain deleted for PHA synthesis. We demonstrated that over-expressing groESL genes led to a better tolerance of the strain towards exogenous isopropanol. GroESL genes were then over-expressed within the best engineered isopropanol producing strain. A final isopropanol concentration of 9.8gL(-1) was achieved in fed-batch culture on fructose as the sole carbon source (equivalent to 16gL(-1) after taking into account evaporation). Cell viability was slightly improved by the chaperone over-expression, particularly at the end of the fermentation when the isopropanol concentration was the highest. Moreover, the strain over-expressing the chaperones showed higher enzyme activity levels of the 2 heterologous enzymes (acetoacetate carboxylase and alcohol dehydrogenase) of the isopropanol synthetic operon, translating to a higher specific production rate of isopropanol at the expense of the specific production rate of acetone. Over-expressing the native chaperones led to a 9-18% increase in the isopropanol yield on fructose. Copyright © 2017 International Metabolic Engineering Society. All rights reserved.

  9. 34 CFR 663.22 - How does the J. William Fulbright Foreign Scholarship Board select fellows?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false How does the J. William Fulbright Foreign Scholarship Board select fellows? 663.22 Section 663.22 Education Regulations of the Offices of the Department of... Scholarship Board select fellows? The J. William Fulbright Foreign Scholarship Board selects fellows on...

  10. Gen IV Materials Handbook Functionalities and Operation

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL

    2009-12-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  11. New AGU Mass Media Fellow Initiated College Science Communication Course

    Science.gov (United States)

    Weiss, Peter

    2010-10-01

    Marissa Weiss, this year's AGU Mass Media Fellow, feels so strongly about communicating science that she and a fellow graduate student started a course on the subject. Three years ago, she and the other student in the biogeochemistry and environmental biocomplexity program at Cornell University, Ithaca, N. Y., developed—with the aid of mentors—a semester­long science communication class. The course has since become a regular offering at Cornell, where Weiss defended her dissertation in ecology this past August. A soil ecologist, Weiss showed in her thesis research that nitrogen pollution can cause slowing of soil decomposition because of a declining abundance of microbes that break the soil down.

  12. Safety and environmental health handbook

    Science.gov (United States)

    ,

    1989-01-01

    This Safety Handbook (445-1-H.) supplements the Geological Survey Safety Management Program objectives set forth in Survey Manual 445.1. Specifically, it provides a compact source of basic information to assist management and employees in preventing motor vehicle accidents, personal injuries, occupational diseases, fire, and other property damage or loss. All work situations incidental to the Geological Survey cannot be discussed in a handbook, and such complete coverage is not intended in this document. However, a wide range of subjects are covered in which a "common sense" approach to safety has been expressed. These subjects have been organized such that Chapters 1-5 address administrative issues, Chapters 6-12 address activities usually conducted within a facility, and Chapters 13-20 address field activities. No information contained in the Handbook is intended to alter any provision of any Federal law or executive order, Department of the Interior or Survey directive, or collective bargaining agreement. Questions or suggestions regarding the content of the Safety Handbook may be directed to the Survey Safety Manager, Administrative Division, Office of Facilities and Management Services, National Center, Reston, Virginia, Mail Stop 246. The previous edition of the Safety Handbook is superseded.

  13. Training residents/fellows in paediatric cardiology: the Emory experience.

    Science.gov (United States)

    Campbell, Robert M

    2016-12-01

    Pediatric cardiology fellowship is a very busy time, with new responsibilities, new knowledge, new technology and fast pace. Above and beyond the science and art of pediatric cardiology, we emphasize that our cardiology fellows are in the middle of the "people business", with additional roles and responsibilities as they serve their patients and communities. This manuscript provides insight into these opportunities for our pediatric cardiac professionals.

  14. Physics GRE Scores of Prize Postdoctoral Fellows in Astronomy

    CERN Document Server

    Levesque, Emily M; Tremblay, Grant R

    2015-01-01

    The Physics GRE is currently a required element of the graduate admissions process in nearly all U.S. astronomy programs; however, its predictive power and utility as a means of selecting "successful" applicants has never been examined. We circulated a short questionnaire to 271 people who have held U.S. prize postdoctoral fellowships in astrophysics between 2010-2015, asking them to report their Physics GRE scores (this should not in any way be interpreted as a belief that a prize fellowship is the best or only metric of "success" in astronomy). The response rate was 64%, and the responding sample is unbiased with respect to the overall gender distribution of prize fellows. The responses reveal that the Physics GRE scores of prize fellows do not adhere to any minimum percentile score and show no statistically significant correlation with the number of first author papers published. As an example, a Physics GRE percentile cutoff of 60% would have eliminated 44% of 2010-2015 U.S. prize postdoctoral fellows, in...

  15. CERN Fellows, don’t splash that cash!

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    When their CERN contracts expire and they leave the Organization, Fellows recoup the amounts paid into the Pension Fund by and for them every month. If they invest this money well, right from the outset, it can grow into a nice little nest-egg by the time they reach retirement age.   As employed members of the CERN personnel, Fellows are members of the Organization’s Pension Fund. Accordingly, a specific amount is withheld from their salary every month (see first box) and, as the months go by, this gradually accumulates into their transfer value (i.e. their capital). When their contracts expire, Fellows may opt to transfer that money directly into another pension fund (subject to the national laws of the destination country and, unfortunately, not possible everywhere), or take it in cash. This is because only employed members of the personnel who have at least five years of service with the Organization are entitled to remain beneficiaries of the CERN Pension Fund for life*. But the capi...

  16. The morphogenesis of herpes simplex virus type 1 in infected parental mouse L fibroblasts and mutant gro29 cells

    DEFF Research Database (Denmark)

    Jensen, Helle Lone; Norrild, Bodil

    2003-01-01

    Mutants of cell lines and viruses are important biological tools. The pathway of herpesvirus particle maturation and egress are contentious issues. The mutant gro29 line of mouse L cells is defective for egress of herpes simplex virus type 1 (HSV-1) virions, and a candidate for studies of virus......-cell interactions. The properties of uninfected and HSV-1-infected L fibroblasts and gro29 cells investigated by protein assay, immunoblot, titration assay, immunofluorescence light microscopy and immunogold cryosection electron microscopy are reported. The ultrastructure of both HSV-1-infected L and gro29 cells...

  17. Handbook of smoke control engineering

    CERN Document Server

    Klote, John H; Turnbull, Paul G; Kashef, Ahmed; Ferreira, Michael J

    2012-01-01

    The Handbook of Smoke Control Engineering extends the tradition of the comprehensive treatment of smoke control technology, including fundamental concepts, smoke control systems, and methods of analysis. The handbook provides information needed for the analysis of design fires, including considerations of sprinklers, shielded fires, and transient fuels. It is also extremely useful for practicing engineers, architects, code officials, researchers, and students. Following the success of Principles of Smoke Management in 2002, this new book incorporates the latest research and advances in smoke control practice. New topics in the handbook are: controls, fire and smoke control in transport tunnels, and full-scale fire testing. For those getting started with the computer models CONTAM and CFAST, there are simplified instructions with examples. This is the first smoke control book with climatic data so that users will have easy-to-use weather data specifically for smoke control design for locations in the U.S., Can...

  18. Handbook on Windows and Energy

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe; Svendsen, Sv Aa Højgaard

    The handbook on windows and energy is a general description of windows with the main focus put on the energy performance. Common window products are described by commonly used nomenclature, description of frame and sash conctructions and description of commonly used glazing types.The energy...... flow and detailed calculation of light and solar transmittance is given.Different measurement techniques for characterization of window heat loss coefficient and total solar energy transmittance is described and references to interantional standards are given.Finally, the handbook includes...... a comprehensive list of window related standards and a list of Nordic research and development projects.Two programs are encloased in the handbook for calculation of solar radiation on inclined surfaces including a shadow correction and a simple program for evaluation of energy savings and risk of overtemperature....

  19. Handbook on the Experience Economy

    DEFF Research Database (Denmark)

    This illuminating Handbook presents the state-of-the-art in the scientific field of experience economy studies. It offers a rich and varied collection of contributions that discuss different issues of crucial importance for our understanding of the experience economy. Each chapter reflects diverse...... scientific viewpoints from disciplines including management, mainstream economics and sociology to provide a comprehensive overview. The Handbook is divided into three subsections to explore progression in the scientific field of experience economy studies. The first section focuses on fundamental debates...... surrounding the nature and importance of the experience economy. The second section presents more specific topics including innovation, networks and the design of experiences. Finally, the last section explores issues such as cultural events, cuisine, theatre and video games. Moreover, the Handbook gives...

  20. Handbook of relativistic quantum chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Wenjian (ed.) [Peking Univ., Beijing (China). Center for Computational Science and Engineering

    2017-03-01

    This handbook focuses on the foundations of relativistic quantum mechanics and addresses a number of fundamental issues never covered before in a book. For instance: How can many-body theory be combined with quantum electrodynamics? How can quantum electrodynamics be interfaced with relativistic quantum chemistry? What is the most appropriate relativistic many-electron Hamiltonian? How can we achieve relativistic explicit correlation? How can we formulate relativistic properties? - just to name a few. Since relativistic quantum chemistry is an integral component of computational chemistry, this handbook also supplements the ''Handbook of Computational Chemistry''. Generally speaking, it aims to establish the 'big picture' of relativistic molecular quantum mechanics as the union of quantum electrodynamics and relativistic quantum chemistry. Accordingly, it provides an accessible introduction for readers new to the field, presents advanced methodologies for experts, and discusses possible future perspectives, helping readers understand when/how to apply/develop the methodologies.

  1. Effective enhancement of Pseudomonas stutzeri D-phenylglycine aminotransferase functional expression in Pichia pastoris by co-expressing Escherichia coli GroEL-GroES

    Directory of Open Access Journals (Sweden)

    Jariyachawalid Kanidtha

    2012-04-01

    Full Text Available Abstract Background D-phenylglycine aminotransferase (D-PhgAT of Pseudomonas stutzeri ST-201 catalyzes the reversible stereo-inverting transamination potentially useful in the application for synthesis of D-phenylglycine and D-4-hydroxyphenylglycine using L-glutamate as a low cost amino donor substrate in one single step. The enzyme is a relatively hydrophobic homodimeric intracellular protein difficult to express in the soluble functionally active form. Over-expression of the dpgA gene in E. coli resulted in the majority of the D-PhgAT aggregated into insoluble inclusion bodies that failed to be re-natured. Expression in Pichia pastoris was explored as an alternative route for high level production of the D-PhgAT. Results Intracellular expression of the codon-optimized synthetic dpgA gene under the PAOX1 promoter in P. pastoris resulted in inactive D-PhgAT associated with insoluble cellular fraction and very low level of D-PhgAT activity in the soluble fraction. Manipulation of culture conditions such as addition of sorbitol to induce intracellular accumulation of osmolytes, addition of benzyl alcohol to induce chaperone expression, or lowering incubation temperature to slow down protein expression and folding rates all failed to increase the active D-PhgAT yield. Co-expression of E. coli chaperonins GroEL-GroES with the D-PhgAT dramatically improved the soluble active enzyme production. Increasing gene dosage of both the dpgA and those of the chaperones further increased functional D-PhgAT yield up to 14400-fold higher than when the dpgA was expressed alone. Optimization of cultivation condition further increased D-PhgAT activity yield from the best co-expressing strain by 1.2-fold. Conclusions This is the first report on the use of bacterial chaperones co-expressions to enhance functional intracellular expression of bacterial enzyme in P. pastoris. Only two bacterial chaperone genes groEL and groES were sufficient for dramatic enhancement of

  2. Handbook on the Experience Economy

    DEFF Research Database (Denmark)

    scientific viewpoints from disciplines including management, mainstream economics and sociology to provide a comprehensive overview. The Handbook is divided into three subsections to explore progression in the scientific field of experience economy studies. The first section focuses on fundamental debates......This illuminating Handbook presents the state-of-the-art in the scientific field of experience economy studies. It offers a rich and varied collection of contributions that discuss different issues of crucial importance for our understanding of the experience economy. Each chapter reflects diverse...

  3. Handbook of mechanical engineering terms

    CERN Document Server

    Ramalingam, KK

    2009-01-01

    About the Book: The Handbook of Mechanical Engineering terms contains short, precise definitions of about four thousand terms. These terms have been collected from different sources, edited and grouped under twenty six parts and given alphabetically under each part for easy reference. The book will be a source of guidance and help to the students, staff and practising engineers in understanding and updating the subject matter. Contents: The Handbook of Mechanical Engineering terms contains short, precise definitions of about four thousand terms. These terms have been collected from differ

  4. Handbook of Open Source Tools

    CERN Document Server

    Koranne, Sandeep

    2011-01-01

    Handbook of Open Source Tools introduces a comprehensive collection of advanced open source tools useful in developing software applications. The book contains information on more than 200 open-source tools which include software construction utilities for compilers, virtual-machines, database, graphics, high-performance computing, OpenGL, geometry, algebra, graph theory , GUIs and more. Special highlights for software construction utilities and application libraries are included. Each tool is covered in the context of a real like application development setting. This unique handbook presents

  5. Handbook of thin film technology

    CERN Document Server

    Frey, Hartmut

    2015-01-01

    Handbook of Thin Film Technology” covers all aspects of coatings preparation, characterization and applications. Different deposition techniques based on vacuum and plasma processes are presented. Methods of surface and thin film analysis including coating thickness, structural, optical, electrical, mechanical and magnetic properties of films are detailed described. The several applications of thin coatings and a special chapter focusing on nanoparticle-based films can be found in this handbook. A complete reference for students and professionals interested in the science and technology of thin films.

  6. Handbook of Visual Display Technology

    CERN Document Server

    Cranton, Wayne; Fihn, Mark

    2012-01-01

    The Handbook of Visual Display Technology is a unique work offering a comprehensive description of the science, technology, economic and human interface factors associated with the displays industry. An invaluable compilation of information, the Handbook will serve as a single reference source with expert contributions from over 150 international display professionals and academic researchers. All classes of display device are covered including LCDs, reflective displays, flexible solutions and emissive devices such as OLEDs and plasma displays, with discussion of established principles, emergent technologies, and particular areas of application. The wide-ranging content also encompasses the fundamental science of light and vision, image manipulation, core materials and processing techniques, display driving and metrology.

  7. 利用膨胀床吸附技术单步纯化分子伴侣—GroEL%Single-step Purification of Molecular Chaperone GroEL by Expanded Bed Chromatography

    Institute of Scientific and Technical Information of China (English)

    佟晓冬; 杨征; 董晓燕; 孙彦

    2003-01-01

    Expanded bed adsorption (EBA) is an integrative downstream processing technique for the purificationof biological substances directly from unclarified feedstock. In this study, molecular chaperone GroEL, an importantprotein folding helper both in vivo and in vitro, was purified by the single-step EBA technique from the unclarifiedhomogenate of recombinant E. coli cells. Compared with packed bed adsorption, the EBA technique provideda single-step approach to yield an electrophoretic purity of GroEL. After the homogenate loading and columnwashing in the expanded bed mode, the GroEL protein was recovered by stepwise salt-gradient elution in packed-bed or expanded-bed modes, respectively. The expanded-bed elution mode was found as efficient as the packed-bedmode in the purification of GroEL from cell disruptate.

  8. THE AIDS HANDBOOK

    Directory of Open Access Journals (Sweden)

    Z Khan

    1997-12-01

    Full Text Available HIV infection and AIDS is increasingly becoming a major public health problem in our country. Currently, the reported cases represent only the 'tip of the iceberg' of the problem. In view of the fact that no cure or vaccine for the disease has yet been found, spreading knowledge and removing misconceptions is about the only way that AIDS can be effectively tackled.This handbook, developed by Prof. Shankar Chowdhury and associates, seeks to address all levels of medical and non-medical AIDS workers, as well as the layman. It deals with topics ranging from biology of the virus, symptoms and transmission of disease, to prevention, counselling for infected persons and action plan for AIDS education.The biology of the virus and the immune system is described in simple terms, as well as methods of testing for HIV, and what these test results mean. The progression of disease in adults and children, development of symptoms, diagnostic criteria for AIDS, treatment and outcome of disease is dealt with. How AIDS spreads between people, and the health risk for health workers and families is examined. The various ways in which transmission of HIV can be prevented is looked at in detail, including public health measures, national and internatonal action, and ethical and human rights issues involved.

  9. Impact Disdrometers Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Bartholomew, Mary Jane [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-03-01

    To improve the quantitative description of precipitation processes in climate models, the U.S. Department of Energy’s Atmospheric Radiation Measurement (ARM) Climate Research Facility has been collecting observations of the drop size spectra of rain events since early in 2006. Impact disdrometers were the initial choice due to their reliability, ease of maintenance, and relatively low cost. Each of the two units deployed was accompanied by a nearby tipping bucket. In 2010, the tipping buckets were replaced by weighing buckets rain gauges. Five video disdrometers were subsequently purchased and are described in ARM’s VDIS Handbook.1 As of April 2011, three of the weighing bucket instruments were deployed, one was to travel with the second ARM Mobile Facility, and the fifth was a spare. Two of the video disdrometers were deployed, a third was to be deployed later in the spring of 2011, one was to travel with the second ARM Mobile Facility, and the last was a spare. Detailed descriptions of impact disdrometers and their datastreams are provided in this document.

  10. The Kilonova Handbook

    CERN Document Server

    Metzger, Brian D

    2016-01-01

    The mergers of double neutron star (NS-NS) and black hole (BH)-NS binaries are promising gravitational wave (GW) sources for Advanced LIGO and future GW detectors. The neutron-rich ejecta from such merger events undergoes rapid neutron capture (r-process) nucleosynthesis, enriching our Galaxy with rare heavy elements like gold and platinum. The radioactive decay of these unstable nuclei also powers a rapidly evolving, supernova-like transient known as a "kilonova". Kilonovae provide an approximately isotropic electromagnetic counterpart to the GW signal, which also provides a unique and direct probe of an important, if not dominant, r-process site. This handbook reviews the history and physics of kilonovae, leading to the current paradigm of week-long emission with a spectral peak at near-infrared wavelengths. Using a simple light curve model to illustrate the basic physics, I introduce potentially important variations on this canonical picture, including: ~day-long optical ("blue") emission from lanthanide-f...

  11. Welding processes handbook

    CERN Document Server

    Weman, Klas

    2003-01-01

    Deals with the main commercially significant and commonly used welding processes. This title takes the student or novice welder through the individual steps involved in each process in an easily understood way. It covers many of the requirements referred to in European Standards including EN719, EN 729, EN 729 and EN 287.$bWelding processes handbook is a concise, explanatory guide to the main commercially significant and commonly-used welding processes. It takes the novice welder or student through the individual steps involved in each process in a clear and easily understood way. It is intended to provide an up-to-date reference to the major applications of welding as they are used in industry. The contents have been arranged so that it can be used as a textbook for European welding courses in accordance with guidelines from the European Welding Federation. Welding processes and equipment necessary for each process are described so that they can be applied to all instruction levels required by the EWF and th...

  12. The Handbook of Second Language Acquisition. Blackwell Handbooks in Linguistics.

    Science.gov (United States)

    Doughty, Catherine J., Ed.; Long, Michael H., Ed.

    This handbook provides an integrated discussion of key issues in second language acquisition (SLA). The 24 chapters include the following: (1) "The Scope of Inquiry and the Goals of SLA" (Catherine J. Doughty and Michael H. Long); (2) "On the Nature of Interlanguage Representation: Universal Grammar in the Second Language"…

  13. Setswana: Special Skills Handbook. Peace Corps Language Handbook Series.

    Science.gov (United States)

    Hopkins, David B., Comp.

    This handbook is a collection of readings intended to acquaint Peace Corps volunteers with the geography of Botswana, and the culture and daily living customs of the people. The introduction provides techniques to help students use the readings to improve their speaking skills. The first section of the text, the "OXFAM Section," contains…

  14. Induction of heat shock proteins DnaK, GroEL, and GroES by salt stress in Lactococcus lactis

    DEFF Research Database (Denmark)

    Kilstrup, Mogens; Jacobsen, Susanne; Hammer, Karin;

    1997-01-01

    The bacterium Lactococcus lactis has become a model organism in studies of growth physiology and membrane transport, as a result of its simple fermentative metabolism. It is also used as a model for studying the importance of specific genes and functions during lie in excess nutrients, by compari......The bacterium Lactococcus lactis has become a model organism in studies of growth physiology and membrane transport, as a result of its simple fermentative metabolism. It is also used as a model for studying the importance of specific genes and functions during lie in excess nutrients......, by comparison of prototrophic wild-type strains and auxotrophic domesticated (daily) strains. In a study of the capacity of domesticated strains to perform directed responses toward various stress conditions, we have analyzed the heat and salt stress response in the established L,. lactis subsp. cremoris...... laboratory strain MG1363, which was originally derived from a dairy strain, After two-dimensional separation of proteins, the DnaK, GroEL, and GroES heat shock proteins, the HrcA (Orf1) heat shack repressor, and the glycolytic enzymes pyruvate kinase, glyceral-dehyde-3-phosphate dehydrogenase...

  15. Perturbation-based Markovian transmission model for probing allosteric dynamics of large macromolecular assembling: a study of GroEL-GroES.

    Directory of Open Access Journals (Sweden)

    Hsiao-Mei Lu

    2009-10-01

    Full Text Available Large macromolecular assemblies are often important for biological processes in cells. Allosteric communications between different parts of these molecular machines play critical roles in cellular signaling. Although studies of the topology and fluctuation dynamics of coarse-grained residue networks can yield important insights, they do not provide characterization of the time-dependent dynamic behavior of these macromolecular assemblies. Here we develop a novel approach called Perturbation-based Markovian Transmission (PMT model to study globally the dynamic responses of the macromolecular assemblies. By monitoring simultaneous responses of all residues (>8,000 across many (>6 decades of time spanning from the initial perturbation until reaching equilibrium using a Krylov subspace projection method, we show that this approach can yield rich information. With criteria based on quantitative measurements of relaxation half-time, flow amplitude change, and oscillation dynamics, this approach can identify pivot residues that are important for macromolecular movement, messenger residues that are key to signal mediating, and anchor residues important for binding interactions. Based on a detailed analysis of the GroEL-GroES chaperone system, we found that our predictions have an accuracy of 71-84% judged by independent experimental studies reported in the literature. This approach is general and can be applied to other large macromolecular machineries such as the virus capsid and ribosomal complex.

  16. Luminosity dependent accretion state change in GRO J1008–57

    Directory of Open Access Journals (Sweden)

    Kühnel Matthias

    2014-01-01

    Full Text Available In a former publication, we have analyzed the transient neutron star X-ray binary GRO J1008–57 using all available RXTE-, Swift-, and Suzaku-data. As we have found, the source’s spectral components, i.e., a power-law with high exponential cutoff and a black-body, are strongly correlated with the hard X-ray flux (15–50 keV. We update the analytical description of these dependence, including a change in the photon index behaviour from a flat to a logarithmic function. The flux, where the change occurs, is consistent with the onset of the black-body emission. Thus, a change of the accretion state always occurs in GRO J1008–57 at a particular flux level.

  17. Adsorption of a model protein, the GroEL chaperonin, on surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Leung, Carl; Palmer, Richard E [Nanoscale Physics Research Laboratory, School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)], E-mail: carl.leung@kcl.ac.uk

    2008-09-03

    Understanding and controlling protein adsorption on surfaces is fundamental to many biological processes ranging from cell adhesion to the fabrication of protein biochips. In general, proteins need to retain their 3D conformation to perform their intended functions. However, when they are presented with a solid surface, complex interactions ranging from weak non-covalent binding to strong covalent bonding may occur, which can potentially induce conformational changes within the adsorbed protein. To investigate the surface adsorption process and its effects on a model protein, the chaperonin GroEL, we have applied contact mode atomic force microscopy, in buffer solution to probe the interactions between single proteins and surfaces in real space. We will discuss the adsorption of GroEL molecules on planar surfaces (mica, graphite and gold) and specifically tailored nanostructured surfaces, which present structural features on the size scale of individual biological molecules. (topical review)

  18. Thermonuclear Burning on the Accreting X-Ray Pulsar GRO J1744-28

    CERN Document Server

    Bildsten, L; Bildsten, Lars; Brown, Edward F.

    1996-01-01

    We investigate the thermal stability of nuclear burning on the accreting X-ray pulsar GRO J1744-28. The neutron star's dipolar magnetic field is 50 years. We also discuss the nature of the binary and point out that a velocity measurement of the stellar companion (most likely a Roche-lobe filling giant with m_K>17) will constrain the neutron star mass.

  19. Anmeldelse af: Handbook of New Age og Handbook of Contemporary Paganism

    DEFF Research Database (Denmark)

    Davidsen, Markus

    2012-01-01

    Anmeldelse af Daren Kemp & James R. Lewis (red.), 2007, Handbook of New Age, Brill, Leiden og Boston og Murphy Pizza & James R. Lewis (red.), 2009, Handbook of Contemporary Paganism, Brill, Leiden og Boston.......Anmeldelse af Daren Kemp & James R. Lewis (red.), 2007, Handbook of New Age, Brill, Leiden og Boston og Murphy Pizza & James R. Lewis (red.), 2009, Handbook of Contemporary Paganism, Brill, Leiden og Boston....

  20. INTEGRAL/XMM views on the MeV source GRO J1411-64

    CERN Document Server

    Torres, D F; Reimer, O; Barcons, X; Corral, A; Bosch-Ramon, V; Paredes, J M; Romero, G E; Qu, J L; Collmar, W; Schönfelder, V; Butt, Y; Torres, Diego F.; Zhang, Shu; Reimer, Olaf; Barcons, Xavier; Corral, Amalia; Bosch-Ramon, Valent\\'{\\i}; Paredes, Josep M.; Romero, Gustavo E.; Qu, Jin Lu; Collmar, Werner; Sch\\"onfelder, Volker; Butt, Yousaf

    2006-01-01

    The COMPTEL unidentified source GRO J 1411-64 was observed by INTEGRAL and XMM-Newton in 2005. The Circinus Galaxy is the only source detected within the 4$\\sigma$ location error of GRO J1411-64, but in here excluded as the possible counterpart. At soft X-rays, 22 reliable and statistically significant sources (likelihood $> 10$) were extracted and analyzed from XMM-Newton data. Only one of these sources, XMMU J141255.6 -635932, is spectrally compatible with GRO J1411-64 although the fact the soft X-ray observations do not cover the full extent of the COMPTEL source position uncertainty make an association hard to quantify and thus risky. At the best location of the source, detections at hard X-rays show only upper limits, which, together with MeV results obtained by COMPTEL suggest the existence of a peak in power output located somewhere between 300-700 keV for the so-called low state. Such a spectrum resembles those in blazars or microquasars, and might suggest at work by a similar scenario. However, an an...

  1. Handbook of signal processing systems

    CERN Document Server

    Bhattacharyya, Shuvra S; Leupers, Rainer; Takala, Jarmo

    2010-01-01

    The Handbook is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools; and the fourth part describes models of computation and their associated design tools and methodologies.

  2. Handbook of nonlinear optical crystals

    CERN Document Server

    Dmitriev, Valentin G; Nikogosyan, David N

    1991-01-01

    This Handbook of Nonlinear Optical Crystals provides a complete description of the properties and applications of nonlinear crystals In addition, it presents the most important equations for calculating the main parameters of nonlinear frequency converters This comprehensive reference work will be of great value to all scientists and engineers working in nonlinear optics, quantum electronics and laser physics

  3. Biofuel technology handbook. 2. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Rutz, Dominik; Janssen, Rainer

    2008-01-15

    This comprehensive handbook was created in order to promote the production and use of biofuels and to inform politicians, decision makers, biofuel traders and all other relevant stakeholders about the state-of-the-art of biofuels and relevant technologies. The large variety of feedstock types and different conversion technologies are described. Explanations about the most promising bio fuels provide a basis to discuss about the manifold issues of biofuels. The impartial information in this handbook further contributes to diminish existing barriers for the broad use of biofuels. Emphasis of this handbook is on first generation biofuels: bio ethanol, Biodiesel, pure plant oil, and bio methane. It also includes second generation biofuels such as BTL-fuels and bio ethanol from lingo-cellulose as well as bio hydrogen. The whole life cycle of bio fuels is assessed under technical, economical, ecological, and social aspect. Characteristics and applications of bio fuels for transport purposes are demonstrated and evaluated. This is completed by an assessment about the most recent studies on biofuel energy balances. This handbook describes the current discussion about green house gas (GHG) balances and sustainability aspects. GHG calculation methods are presented and potential impacts of biofuel production characterized: deforestation of rainforests and wetlands, loss of biodiversity, water pollution, human health, child labour, and labour conditions.

  4. Area Handbook for Sierra Leone,

    Science.gov (United States)

    1976-01-01

    During its fifteen years of independence since 1961, Sierra Leone has had some difficulty in maintaining political stability and in generating...performance has been comparatively weak. By the mid-1970s, however, there were indications that it might improve. The Area Handbook for Sierra Leone

  5. Early Childhood Educator's Nutrition Handbook.

    Science.gov (United States)

    Olson, Christine; And Others

    This nutrition handbook is designed to provide enough information on nutrition and food habits to enable early childhood educators to add a nutrition dimension to children's learning activities. Topics covered are the role of nutrition in growth during the preschool years; nutrients and their functions; selecting a healthy diet; common nutritional…

  6. Handbook for Prospective Single Parents.

    Science.gov (United States)

    Marindin, Hope

    This handbook for prospective single adoptive parents provides information on locating and adopting a child, necessary clothing and supplies for children of various ages, health and day care arrangements, expenses incurred after adoption, various financial benefits and subsidies available to the adoptive parent, and legal and financial provisions…

  7. Handbook on Marketing Vocational Education.

    Science.gov (United States)

    Martin, William R.

    Compiled after interviews with vocational educators at urban and rural joint vocational schools, comprehensive high schools, and career centers considered to be successful at marketing vocational education locally in Ohio, this handbook contains information on successful marketing activities that other local educators can undertake. Section I…

  8. Handbook of Advanced Multilevel Analysis

    CERN Document Server

    Hox, Joop

    2010-01-01

    This new handbook is the definitive resource on advanced topics related to multilevel analysis. The editors have assembled the top minds in the field to address the latest applications of multilevel modeling as well as the specific difficulties and methodological problems that are becoming more common as more complicated models are developed.

  9. Dentistry and Dental Hygiene Handbook.

    Science.gov (United States)

    New York State Education Dept., Albany. Office of the Professions.

    The handbook contains laws, rules, and regulations of the New York State Education Department that govern dentistry and dental hygiene practice in the state. It describes licensure requirements and includes complete application forms and instructions for obtaining license and first registration as a dentist and dental hygienist. Applicants are…

  10. Information Handbook for Teacher Aides.

    Science.gov (United States)

    Pucciarelli, Catherine S., Ed.

    This handbook provides an introduction for teacher aides recently hired by the Nassau Board of Cooperative Education Services (BOCES) to work with handicapped students. Topics covered include mental, learning, physical and emotional disabilities, the role of the teacher aide, crisis intervention, building students' self-esteem, managing student…

  11. Handbook for Public Playground Safety.

    Science.gov (United States)

    Consumer Product Safety Commission, Washington, DC.

    Guidelines for playground equipment safety are presented in this handbook. It first provides an overview of common playground injuries and definitions. The layout and design of playgrounds, such as choosing a site, locating equipment, and separating equipment by age level, is addressed next. The remaining sections describe the installation and…

  12. Handbook of Applied Behavior Analysis

    Science.gov (United States)

    Fisher, Wayne W., Ed.; Piazza, Cathleen C., Ed.; Roane, Henry S., Ed.

    2011-01-01

    Describing the state of the science of ABA, this comprehensive handbook provides detailed information about theory, research, and intervention. The contributors are leading ABA authorities who present current best practices in behavioral assessment and demonstrate evidence-based strategies for supporting positive behaviors and reducing problem…

  13. Promotion & Publicity Handbook for Broadcasters.

    Science.gov (United States)

    Gompertz, Rolf

    This handbook gives practical suggestions for organizing and conducting publicity campaigns. It is directed to media publicists working for private agencies, studios, stations, or networks; however, the methods and principles discussed apply to all fields of publicity. The book discusses the following topics: the publicity campaign; the press kit,…

  14. The Digital technical documentation handbook

    CERN Document Server

    Schultz, Susan I; Kavanagh, Frank X; Morse, Marjorie J

    1993-01-01

    The Digital Technical Documentation Handbook describes the process of developing and producing technical user information at Digital Equipment Corporation. * Discusses techniques for making user information _more effective * Covers the draft and reviewprocess, the production and distribution of printed and electronic media, archiving, indexing, testing for usability, and many other topics * Provides quality assurance checklists, contains a glossary and a bibliography of resources for technicalcommunicators

  15. Handbook for Preparing Job Classifications.

    Science.gov (United States)

    Thomas, John C.

    To assist local governments in their responsibility for eliminating and preventing discrimination in employment based on race, color, religion, sex, or national origin as specified by the Equal Employment Opportunity Act of 1972, the handbook provides guidelines for analyzing jobs and preparing job classifications (defining; listing duties…

  16. Director of Financial Aid Handbook.

    Science.gov (United States)

    Sorenson, Lynn D.

    Although many independent schools are seeing a diversification in their student bodies, existing structures, such as financial aid awards, have not been modified. In addition, many financial-aid managers in independent schools have 0-5 years of experience in student financial aid. This handbook profiles the overall step-by-step process for…

  17. Handbook for Resource Development Internships.

    Science.gov (United States)

    Southern Regional Education Board, Atlanta, GA.

    The Resource Development Project of the Southern Regional Education Board, in conjunction with federal, state and local agencies and southern colleges and universities has organized a service-learning internship program for college students. This handbook is designed as a guide for student interns and project committee members as they work…

  18. The National Pancreas Foundation fellows symposium program 2006 to 2009.

    Science.gov (United States)

    Gelrud, Andres; Whitcomb, David C

    2010-04-01

    Clinical and translational research is critical for the development of improvement in care of pancreatic diseases. Major concerns are the lack of dedicated trainees in pancreatic research and the difficulty for the remaining trainees to develop independent research careers to be included into the pancreas research community. This article describes the efforts of Solvay Pharmaceuticals and American academic leaders working through the National Pancreas Foundation to facilitate the development and expansion of a new generation of pancreas-related clinical and translational researchers through a 3-year fellows symposium.

  19. Temporal Variations And Spectral Properties of Be/X-ray Pulsar GRO J1008-57 Studied by INTEGRAL

    CERN Document Server

    Wang, Wei

    2013-01-01

    Spin period variations and hard X-ray spectral properties of Be/X-ray pulsar GRO J1008-57 are studied with INTEGRAL observations. The pulsation periods at 93.66 s in 2004 and at 93.73 s in 2009 are determined. Pulse profiles of GRO J1008-57 during outbursts are energy dependent: double-peak profile in soft bands of 3-7 keV and single-peak profile in hard X-rays above 7 keV. GRO J1008-57 has undergone a spin-down trend from 1993-2009 with a rate of 4.1x10^-5 s day^-1, and might transfer into a spin-up trend after 2009. The spectra from 3-100 keV of GRO J1008-57 during outbursts are fitted with photon index of 1.4 and cutoff energies of 23-29 keV. We find a relatively soft spectrum in early phase of the 2009 outburst with cutoff energy 13 keV. Above a hard X-ray flux of 10^-9 erg cm^-2 s^-1, the spectra of GRO J1008-57 during outbursts need an enhanced hydrogen absorption of column density 6x10^22 cm^-2. The observed dip-like pulse profile of GRO J1008-57 in soft X-ray bands should be caused by this intrinsic a...

  20. Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR

    Science.gov (United States)

    Libich, David S.; Tugarinov, Vitali; Clore, G. Marius

    2015-01-01

    The prototypical chaperonin GroEL assists protein folding through an ATP-dependent encapsulation mechanism. The details of how GroEL folds proteins remain elusive, particularly because encapsulation is not an absolute requirement for successful re/folding. Here we make use of a metastable model protein substrate, comprising a triple mutant of Fyn SH3, to directly demonstrate, by simultaneous analysis of three complementary NMR-based relaxation experiments (lifetime line broadening, dark state exchange saturation transfer, and Carr–Purcell–Meinboom–Gill relaxation dispersion), that apo GroEL accelerates the overall interconversion rate between the native state and a well-defined folding intermediate by about 20-fold, under conditions where the “invisible” GroEL-bound states have occupancies below 1%. This is largely achieved through a 500-fold acceleration in the folded-to-intermediate transition of the protein substrate. Catalysis is modulated by a kinetic deuterium isotope effect that reduces the overall interconversion rate between the GroEL-bound species by about 3-fold, indicative of a significant hydrophobic contribution. The location of the GroEL binding site on the folding intermediate, mapped from 15N, 1HN, and 13Cmethyl relaxation dispersion experiments, is composed of a prominent, surface-exposed hydrophobic patch. PMID:26124125

  1. The use of handbooks in orthopaedics.

    Science.gov (United States)

    Giddins, G E; Kurer, M H

    1994-11-01

    The use of handbooks is becoming more widespread in hospital medicine. A review of their use in British orthopaedics received 78 replies (29 per cent) representing 94 (30 per cent) of the orthopaedic units in the United Kingdom. Seventy-five per cent used a handbook, were preparing one or would like to have one. Recommendations are given for the content and format of a handbook, a specimen of which has been prepared.

  2. Handbook of bioplastics and biocomposites engineering applications

    National Research Council Canada - National Science Library

    Pilla, Srikanth

    2011-01-01

    "The Handbook of Bioplastics & Biocomposites Engineering Applications brings together scientists, from academia and industries, to report on current research and applications, in the bioplastics and biocomposites arena...

  3. Training fellows in paediatric cardiology: the Harvard experience.

    Science.gov (United States)

    Brown, David W; Allan, Catherine K; Newburger, Jane W

    2016-12-01

    The Fellowship Program of the Department of Cardiology at Boston Children's Hospital seeks to train academically oriented leaders in clinical care and laboratory and clinical investigation of cardiovascular disease in the young. The core clinical fellowship involves 3 years in training, comprising 24 months of clinical rotations and 12 months of elective and research experience. Trainees have access to a vast array of research opportunities - clinical, basic, and translational. Clinical fellows interested in basic science may reverse the usual sequence and start their training in the laboratory, deferring clinical training for 1 or more years. An increasing number of clinical trainees apply to spend a fourth year as a senior fellow in one of the subspecialty areas of paediatric cardiology. From the founding of the Department to the present, we have maintained a fundamental and unwavering commitment to training and education in clinical care and research in basic science and clinical investigation, as well as to the training of outstanding young clinicians and investigators.

  4. Career choice selection and satisfaction among US adult nephrology fellows.

    Science.gov (United States)

    Shah, Hitesh H; Jhaveri, Kenar D; Sparks, Matthew A; Mattana, Joseph

    2012-09-01

    Although many anticipate that there will be an eventual shortage of practicing nephrologists, a complete understanding is lacking regarding the current factors that lead US adult nephrology fellows to choose nephrology as a career and their satisfaction with this choice. It is of great concern that interest in obtaining nephrology fellowship training continues to decline in the United States, especially among US medical graduates, and the reasons for this are unclear. The exposure that students and residents have to nephrology is likely to play an important role in the career choices that they make and their ultimate satisfaction with this career choice is likely influenced by several factors, including job opportunities. Some of the findings presented here suggest that there may be a high percentage of nephrology fellows who are dissatisfied with their career choice. Failure to understand the factors that influence trainees to choose nephrology as a career and those that affect their satisfaction with this choice may impair the ability to graduate a sufficient number of nephrologists to meet projected demand. In this article, a number of variables related to the choice of nephrology as a career and satisfaction with a career in nephrology are discussed. Some steps that the nephrology training community might take to help promote interest in nephrology and optimize the satisfaction that nephrology graduates derive from their careers are also proposed.

  5. Gen IV Materials Handbook Functionalities and Operation (2B) Handbook Version 2.0

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL

    2011-08-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  6. Gen IV Materials Handbook Functionalities and Operation (4A) Handbook Version 4.0

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL

    2013-09-01

    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  7. Handbook of Ecotoxicology

    Science.gov (United States)

    Hoffman, D.J.; Rattner, B.A.; Burton, G.A.; Cairns, J.

    2003-01-01

    This second edition of the Handbook of Ecotoxicology has expanded considerably in both concept and content over the first edition. The second edition contains 45 chapters with contributions from over 75 international experts. Eighteen new chapters have been introduced, and the original chapters have been substantially revised and updated. All of the content has been reviewed by a board of experts. This edition is divided into five major sections: I. Quantifying and Measuring Ecotoxicological Effects, II. Contaminant Sources and Effects, III. Case Histories and Ecosystem Surveys, IV. Methods for Making Estimates, Predictability, and Risk Assessment in Ecotoxicology, and V. Special Issues in Ecotoxicology. In the first section, concepts and current methodologies for testing are provided for aquatic toxicology, wildlife toxicology, sediment toxicity, soil ecotoxicology, algal and plant toxicity, and landscape ecotoxicology. Biomonitoring programs and current use of bio-indicators for aquatic and terrestrial monitoring are described. The second section contains chapters on major environmental contaminants and other anthropogenic processes capable of disrupting ecosystems including pesticides, petroleum and PAHs, heavy metals, selenium, polyhalogenated aromatic hydrocarbons, urban runoff, nuclear and thermal contamination, global effects of deforestation, pathogens and disease, and abiotic factors that interact with contaminants. In order to illustrate the full impact of different environmental contaminants on diverse ecosystems, seven case histories and ecosystem surveys are described in the third section. The fourth section discusses methods and approaches used for estimating and predicting exposure and effects for purposes of risk assessment. These include global disposition of contaminants, bioaccumulation and bioconcentration, use of quantitative structure activity relationships (QSARs), population modeling, current guidelines and future directions for ecological

  8. Stress and burnout among critical care fellows: preliminary evaluation of an educational intervention

    OpenAIRE

    Kashani, Kianoush; Carrera, Perliveh; Gallo de Moraes, Alice; Sood, Amit; Onigkeit, James A; Ramar, Kannan

    2015-01-01

    Background: Despite a demanding work environment, information on stress and burnout of critical care fellows is limited.Objectives: To assess 1) levels of burnout, perceived stress, and quality of life in critical care fellows, and 2) the impact of a brief stress management training on these outcomes.Methods: In a tertiary care academic medical center, 58 critical care fellows of varying subspecialties and training levels were surveyed to assess baseline levels of stress and burnout. Twenty-o...

  9. Increased expression and purification of soluble iron-regulatory protein 1 from Escherichia coli co-expressing chaperonins GroES and GroEL

    Directory of Open Access Journals (Sweden)

    H. Carvalho

    2008-04-01

    Full Text Available Iron is an essential metal for all living organisms. However, iron homeostasis needs to be tightly controlled since iron can mediate the production of reactive oxygen species, which can damage cell components and compromise the integrity and/or cause DNA mutations, ultimately leading to cancer. In eukaryotes, iron-regulatory protein 1 (IRP1 plays a central role in the control of intracellular iron homeostasis. This occurs by interaction of IRP1 with iron-responsive element regions at 5' of ferritin mRNA and 3' of transferrin mRNA which, respectively, represses translation and increases mRNA stability. We have expressed IRP1 using the plasmid pT7-His-hIRP1, which codifies for human IRP1 attached to an NH2-terminal 6-His tag. IRP1 was expressed in Escherichia coli using the strategy of co-expressing chaperonins GroES and GroEL, in order to circumvent inclusion body formation and increase the yield of soluble protein. The protein co-expressed with these chaperonins was obtained mostly in the soluble form, which greatly increased the efficiency of protein purification. Metal affinity and FPLC ion exchange chromatography were used in order to obtain highly purified IRP1. Purified protein was biologically active, as assessed by electrophoretic mobility shift assay, and could be converted to the cytoplasmic aconitase form. These results corroborate previous studies, which suggest the use of folding catalysts as a powerful strategy to increase protein solubility when expressing heterologous proteins in E. coli.

  10. Presidential Management Fellows (PMF) Talent Acquisition System, PMF-TAS (ACCESS CONTROLLED)

    Data.gov (United States)

    Office of Personnel Management — Application and Assessment system for Presidential Management Fellows (PMF) and PMF Science, Technology, Engineering, and Math (STEM) programs. This sytem is access...

  11. 41 CFR 101-29.301-2 - Federal Standardization Handbook.

    Science.gov (United States)

    2010-07-01

    ... Handbook. 101-29.301-2 Section 101-29.301-2 Public Contracts and Property Management Federal Property... PRODUCT DESCRIPTIONS 29.3-Responsibilities § 101-29.301-2 Federal Standardization Handbook. The Assistant... Standardization Handbook.” The Federal Standardization Handbook sets forth operating procedures and applicable...

  12. 47 CFR 11.15 - EAS Operating Handbook.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false EAS Operating Handbook. 11.15 Section 11.15... Operating Handbook. The EAS Operating Handbook states in summary form the actions to be taken by personnel.... It is issued by the FCC and contains instructions for the above situations. A copy of the Handbook...

  13. Springer handbook of ocean engineering

    CERN Document Server

    Xiros, Nikolaos

    2016-01-01

    The handbook is the definitive reference for the interdisciplinary field that is ocean engineering. It integrates the coverage of fundamental and applied material and encompasses a diverse spectrum of systems, concepts and operations in the maritime environment, as well as providing a comprehensive update on contemporary, leading-edge ocean technologies. Coverage includes but is not limited to; an overview of ocean science, ocean signals and instrumentation, coastal structures, developments in ocean energy technologies, and ocean vehicles and automation. The handbook will be of interest to practitioners in a range of offshore industries and naval establishments as well as academic researchers and graduate students in ocean, coastal, offshore, and marine engineering and naval architecture.

  14. The handbook of journal publishing

    CERN Document Server

    Morris, Sally; LaFrenier, Douglas; Reich, Margaret

    2013-01-01

    The Handbook of Journal Publishing is a comprehensive reference work written by experienced professionals, covering all aspects of journal publishing, both online and in print. Journals are crucial to scholarly communication, but changes in recent years in the way journals are produced, financed, and used make this an especially turbulent and challenging time for journal publishers - and for authors, readers, and librarians. The Handbook offers a thorough guide to the journal publishing process, from editing and production through marketing, sales, and fulfilment, with chapters on management, finances, metrics, copyright, and ethical issues. It provides a wealth of practical tools, including checklists, sample documents, worked examples, alternative scenarios, and extensive lists of resources, which readers can use in their day-to-day work. Between them, the authors have been involved in every aspect of journal publishing over several decades and bring to the text their experience working for a wide range of ...

  15. Handbook of advanced lighting technology

    CERN Document Server

    Sun, Ching-Cherng; Zissis, Georges; Ma, Ruiqing

    2017-01-01

    The Handbook of Advanced Lighting Technology is a major reference work on the subject of light source science and technology, with particular focus on solid-state light sources – LEDs and OLEDs – and the development of 'smart' or 'intelligent' lighting systems; and the integration of advanced light sources, sensors, and adaptive control architectures to provide tailored illumination which is 'fit to purpose.' The concept of smart lighting goes hand-in-hand with the development of solid-state light sources, which offer levels of control not previously available with conventional lighting systems. This has impact not only at the scale of the individual user, but also at an environmental and wider economic level. These advances have enabled and motivated significant research activity on the human factors of lighting, particularly related to the impact of lighting on healthcare and education, and the Handbook provides detailed reviews of work in these areas. The potential applications for smart lighting span ...

  16. Handbook of Molecular Force Spectroscopy

    CERN Document Server

    Noy, Aleksandr

    2008-01-01

    "...Noy's Handbook of Molecular Force Spectroscopy is both a timely and useful summary of fundamental aspects of molecular force spectroscopy, and I believe it would make a worthwhile addition to any good scientific library. New research groups that are entering this field would be well advisedto study this handbook in detail before venturing into the exciting and challenging world of molecular force spectroscopy." Matthew F. Paige, University of Saskatchewan, Journal of the American Chemical Society Modern materials science and biophysics are increasingly focused on studying and controlling intermolecular interactions on the single-molecule level. Molecular force spectroscopy was developed in the past decade as the result of several unprecedented advances in the capabilities of modern scientific instrumentation, and defines a number of techniques that use mechanical force measurements to study interactions between single molecules and molecular assemblies in chemical and biological systems. Examples of these...

  17. Integrated Baseline Review (IBR) Handbook

    Science.gov (United States)

    Fleming, Jon F.; Kehrer, Kristen C.

    2016-01-01

    The purpose of this handbook is intended to be a how-to guide to prepare for, conduct, and close-out an Integrated Baseline Review (IBR). It discusses the steps that should be considered, describes roles and responsibilities, tips for tailoring the IBR based on risk, cost, and need for management insight, and provides lessons learned from past IBRs. Appendices contain example documentation typically used in connection with an IBR. Note that these appendices are examples only, and should be tailored to meet the needs of individual projects and contracts. Following the guidance in this handbook will help customers and suppliers preparing for an IBR understand the expectations of the IBR, and ensure that the IBR meets the requirements for both in-house and contract efforts.

  18. LAWRENCE RADIATION LABORATORY COUNTING HANDBOOK

    Energy Technology Data Exchange (ETDEWEB)

    Group, Nuclear Instrumentation

    1966-10-01

    The Counting Handbook is a compilation of operational techniques and performance specifications on counting equipment in use at the Lawrence Radiation Laboratory, Berkeley. Counting notes have been written from the viewpoint of the user rather than that of the designer or maintenance man. The only maintenance instructions that have been included are those that can easily be performed by the experimenter to assure that the equipment is operating properly.

  19. Handbook of luminescent semiconductor materials

    CERN Document Server

    Bergman, Leah

    2011-01-01

    Photoluminescence spectroscopy is an important approach for examining the optical interactions in semiconductors and optical devices with the goal of gaining insight into material properties. With contributions from researchers at the forefront of this field, Handbook of Luminescent Semiconductor Materials explores the use of this technique to study semiconductor materials in a variety of applications, including solid-state lighting, solar energy conversion, optical devices, and biological imaging. After introducing basic semiconductor theory and photoluminescence principles, the book focuses

  20. Measurement, instrumentation, and sensors handbook

    CERN Document Server

    Eren, Halit

    2014-01-01

    The Second Edition of the bestselling Measurement, Instrumentation, and Sensors Handbook brings together all aspects of the design and implementation of measurement, instrumentation, and sensors. Reflecting the current state of the art, it describes the use of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and the life sciences and discusses processing systems, automatic data acquisition, reduction and analysis, operation characteristics, accuracy, errors, calibrations, and the incorporation of standards for control purposes. Organized acco

  1. Science of reading a handbook

    CERN Document Server

    Snowling, Margaret J

    2008-01-01

    ""In the rapidly burgeoning, cumulative progress that characterizes our field today, this is the compendium that everyone needs. Graduate students and researchers alike will feast on this collection."" Professor Keith E. Stanovich, University of Toronto, Canada ""This authoritative handbook defines the science of reading, reviewing the huge advances in knowledge over the last thirty years in a dazzling display of scholarship. No one interested in the psychology of reading can do without it."" Professor Uta Frith, Institute of Cognitive Neuroscience, University Col

  2. Handbook of structural equation modeling

    CERN Document Server

    Hoyle, Rick H

    2012-01-01

    The first comprehensive structural equation modeling (SEM) handbook, this accessible volume presents both the mechanics of SEM and specific SEM strategies and applications. The editor, contributors, and editorial advisory board are leading methodologists who have organized the book to move from simpler material to more statistically complex modeling approaches. Sections cover the foundations of SEM; statistical underpinnings, from assumptions to model modifications; steps in implementation, from data preparation through writing the SEM report; and basic and advanced applications, inclu

  3. Industrial hazard and safety handbook

    CERN Document Server

    King, Ralph W

    1979-01-01

    Industrial Hazard and Safety Handbook (Revised Impression) describes and exposes the main hazards found in industry, with emphasis on how these hazards arise, are ignored, are identified, are eliminated, or are controlled. These hazard conditions can be due to human stresses (for example, insomnia), unsatisfactory working environments, as well as secret industrial processes. The book reviews the cost of accidents, human factors, inspections, insurance, legal aspects, planning for major emergencies, organization, and safety measures. The text discusses regulations, codes of practice, site layou

  4. Handbook of hydraulic fluid technology

    CERN Document Server

    Totten, George E

    2011-01-01

    ""The Handbook of Hydraulic Fluid Technology"" serves as the foremost resource for designing hydraulic systems and for selecting hydraulic fluids used in engineering applications. Featuring new illustrations, data tables, as well as practical examples, this second edition is updated with essential information on the latest hydraulic fluids and testing methods. The detailed text facilitates unparalleled understanding of the total hydraulic system, including important hardware, fluid properties, and hydraulic lubricants. Written by worldwide experts, the book also offers a rigorous overview of h

  5. Optical Rain Gauge Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Bartholomew, Mary Jane [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-04-01

    To improve the quantitative description of precipitation processes in climate models, the U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement (ARM) Climate Research Facility deploys several types of rain gauges (MET, RAIN, and optical rain gauge [ORG] datastreams) as well as disdrometers (DISD and VDIS datastreams) at the Southern Great Plains (SGP) Site. This handbook deals specifically with the independent analog ORG (i.e., the ORG datastream).

  6. Springer handbook of computational intelligence

    CERN Document Server

    Pedrycz, Witold

    2015-01-01

    This is the first book covering the basics and the state of the art and important applications of the complete growing discipline of computational intelligence. This comprehensive handbook presents a unique synergy of various approaches and new qualities to be gained by using hybrid approaches, incl. inspirations from biology and living organisms and animate systems. The text is organized in 7 main parts foundations, fuzzy sets, rough sets, evolutionary computation, neural networks, swarm intelligence and hybrid computational intelligence systems.

  7. Biomedical photonics handbook biomedical diagnostics

    CERN Document Server

    Vo-Dinh, Tuan

    2014-01-01

    Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, studen

  8. The handbook of artificial intelligence

    CERN Document Server

    Barr, Avron

    1982-01-01

    The Handbook of Artificial Intelligence, Volume II focuses on the improvements in artificial intelligence (AI) and its increasing applications, including programming languages, intelligent CAI systems, and the employment of AI in medicine, science, and education. The book first elaborates on programming languages for AI research and applications-oriented AI research. Discussions cover scientific applications, teiresias, applications in chemistry, dependencies and assumptions, AI programming-language features, and LISP. The manuscript then examines applications-oriented AI research in medicine

  9. GroEL to DnaK chaperone network behind the stability modulation of σ(32) at physiological temperature in Escherichia coli.

    Science.gov (United States)

    Patra, Monobesh; Roy, Sourav Singha; Dasgupta, Rakhi; Basu, Tarakdas

    2015-12-21

    The stability of heat-shock transcription factor σ(32) in Escherichia coli has long been known to be modulated only by its own transcribed chaperone DnaK. Very few reports suggest a role for another heat-shock chaperone, GroEL, for maintenance of cellular σ(32) level. The present study demonstrates in vivo physical association between GroEL and σ(32) in E. coli at physiological temperature. This study further reveals that neither DnaK nor GroEL singly can modulate σ(32) stability in vivo; there is an ordered network between them, where GroEL acts upstream of DnaK.

  10. Effects of the chaperonin GroE on the refolding of tryptophanase from Escherichia coli. Refolding is enhanced in the presence of ADP.

    Science.gov (United States)

    Mizobata, T; Akiyama, Y; Ito, K; Yumoto, N; Kawata, Y

    1992-09-01

    The refolding of the tetrameric enzyme tryptophanase was facilitated by the chaperonin GroE. Maximum refolding yield of tryptophanase molecules (about 80%) was attained in the presence of a 15-fold excess of GroE 21-mer over tryptophanase monomer. The GroEL subunit was required for this improvement in refolding yield, whereas the GroES subunit was not. Light scattering experiments of the refolding reaction revealed that GroE bound to tryptophanase folding intermediates and suppressed their aggregation. The presence of ATP was required for the efficient dissociation of tryptophanase from GroEL. However, our experiments indicated that tryptophanase dissociated readily from GroEL in the presence of not only ATP, but also in the presence of non-hydrolyzable ATP analogues such as ATP gamma S (adenosine 5'-O-(3-thiotriphosphate)) and AMP-PNP (adenyl-5'-yl imidodiphosphate) as well. Surprisingly, the release of tryptophanase from GroEL was facilitated in the presence of ADP as well. We concluded that the binding of nucleotides such as ATP and ADP changed the conformation of GroEL and facilitated the dissociation of tryptophanase molecules. The conformation formed in the presence of ADP was distinct from the conformation formed in the presence of ATP, as shown by the selective dissociation of various folding proteins from the two conformations.

  11. Society News: Workshop helps new GJI authors; Free eBook for schools; EGU awards medal; AGU elects Fellow; Support your Society; New Fellows

    Science.gov (United States)

    2012-04-01

    Early-career researchers and postgraduates are invited to attend an Author Workshop at the 2012 European Geosciences Union General Assembly in Vienna. The following were elected Fellows of the Society on 10 February 2012:

  12. Evaluation of a web-based portal to improve resident education by neonatology fellows

    Directory of Open Access Journals (Sweden)

    Ashwini Lakshmanan

    2014-07-01

    Full Text Available Background: Integration of web-based educational tools into medical training has been shown to increase accessibility of resources and optimize teaching. We developed a web-based educational portal (WBEP to support teaching of pediatric residents about newborn medicine by neonatology fellows. Objectives: 1 To compare residents’ attitudes about their fellow-led education in the NICU pre- and post-WBEP; including assessment of factors that impact their education and usefulness of teaching tools. 2 To compare fellow utilization of various teaching modalities pre- and post-WBEP. Design/methods: We queried residents about their attitudes regarding fellow-led education efforts and various teaching modalities in the NICU and logistics potentially impacting effectiveness. Based on these data, we introduced the WBEP – a repository of teaching tools (e.g., mock code cases, board review questions, journal articles, case-based discussion scenarios for use by fellows to supplement didactic sessions in a faculty-based curriculum. We surveyed residents about the effectiveness of fellow teaching pre- and post-WBEP implementation and the type of fellow-led teaching modalities that were used. Results: After analysis of survey responses, we identified that residents cited fellow level of interest as the most important factor impacting their education. Post-implementation, residents described greater utilization of various teaching modalities by fellows, including an increase in use of mock codes (14% to 76%, p<0.0001 and journal articles (33% to 59%, p=0.02. Conclusions: A web-based resource that supplements traditional curricula led to greater utilization of various teaching modalities by fellows and may encourage fellow involvement in resident teaching.

  13. Come Spin a Yarn: The Storytelling Handbook.

    Science.gov (United States)

    Rudin, Claire

    An outgrowth of the New York City Annual Storytelling Festival, this handbook presents a framework upon which to build a storytelling program for children. The handbook is intended to prompt additional exploration of the literature on storytelling and folklore and help start storytelling programs, contests, and festivals in schools. The handbook…

  14. DOE handbook table-top needs analysis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Purpose of this handbook is to establish guidelines for training personnel in developing training for operation, maintenance, and technical support personnel at DOE nuclear facilities. Information from this handbook can be used to conduct needs analysis as the information and methods apply. Operating contractors are encouraged to use good practices selectively in developing or improving programs to meet the specific needs of their facility.

  15. Data Display Markup Language (DDML) Handbook

    Science.gov (United States)

    2017-01-31

    Moreover, the tendency of T&E is towards a plug-and-play-like data acquisition system that requires standard languages and modules for data displays...Telemetry Group DOCUMENT 127-17 DATA DISPLAY MARKUP LANGUAGE (DDML) HANDBOOK DISTRIBUTION A: APPROVED FOR...DOCUMENT 127-17 DATA DISPLAY MARKUP LANGUAGE (DDML) HANDBOOK January 2017 Prepared by Telemetry Group

  16. EURANOS. The Handbook Users Group (HUG)

    DEFF Research Database (Denmark)

    Nisbet, A.F.; Andersson, Kasper Grann; Carlé, B.

    Three handbooks to assist in the management of contaminated food production systems, inhabited areas and drinking water supplies have been developed in conjunction with a wide range of stakeholders in Europe. These handbooks are living documents that will require updating from time to time...

  17. Stop the Bullying: A Handbook for Schools.

    Science.gov (United States)

    Rigby, Ken

    Noting that bullying in school is a growing concern in Australian communities, this handbook draws upon a 10-year study of bullying in Australian schools and is designed to help educators find out what is happening in their school and develop sound anti-bullying policies. The handbook also provides guidance in working effectively with students to…

  18. Alberta Associations for Bright Children Members' Handbook.

    Science.gov (United States)

    Alberta Association for Bright Children, Edmonton.

    This handbook is designed to provide information to parents of gifted children in Alberta, Canada. The handbook outlines the mission and objectives of the Alberta Associations for Bright Children and describes the structure of the non-profit organization. The booklet then addresses: (1) the characteristics of gifted children; (2) the rights of…

  19. Program and Course Approval Handbook. Fifth Edition

    Science.gov (United States)

    California Community Colleges, Chancellor's Office, 2013

    2013-01-01

    This "Program and Course Approval Handbook" assists California Community College (CCC) administrators, faculty, and staff in the development of programs and courses and the submission of these proposals for review by the Chancellor's Office. By law, the Chancellor is required to prepare and distribute a handbook for program and course…

  20. Asian-American Media Skills Handbook.

    Science.gov (United States)

    Haines, Roberta M., Comp.

    This handbook is for teachers to use in the classroom and as a reference source for information about Asia and Asian-Americans. The handbook uses information about geography and culture to teach skills such as almanac, atlas, and encyclopedia use. Other student exercises include: how to sequence a Chinese fairy tale and present it to the class,…

  1. An insecticidal GroEL protein with chitin binding activity from Xenorhabdus nematophila.

    Science.gov (United States)

    Joshi, Mohan Chandra; Sharma, Animesh; Kant, Sashi; Birah, Ajanta; Gupta, Gorakh Prasad; Khan, Sharik R; Bhatnagar, Rakesh; Banerjee, Nirupama

    2008-10-17

    Xenorhabdus nematophila secretes insecticidal proteins to kill its larval prey. We have isolated an approximately 58-kDa GroEL homolog, secreted in the culture medium through outer membrane vesicles. The protein was orally insecticidal to the major crop pest Helicoverpa armigera with an LC50 of approximately 3.6 microg/g diet. For optimal insecticidal activity all three domains of the protein, apical, intermediate, and equatorial, were necessary. The apical domain alone was able to bind to the larval gut membranes and manifest low level insecticidal activity. At equimolar concentrations, the apical domain contained approximately one-third and the apical-intermediate domain approximately one-half bioactivity of that of the full-length protein. Interaction of the protein with the larval gut membrane was specifically inhibited by N-acetylglucosamine and chito-oligosaccharides. Treatment of the larval gut membranes with chitinase abolished protein binding. Based on the three-dimensional structural model, mutational analysis demonstrated that surface-exposed residues Thr-347 and Ser-356 in the apical domain were crucial for both binding to the gut epithelium and insecticidal activity. Double mutant T347A,S356A was 80% less toxic (p activity with Kd approximately 0.64 microm and Bmax approximately 4.68 micromol/g chitin. The variation in chitin binding activity of the mutant proteins was in good agreement with membrane binding characteristics and insecticidal activity. The less toxic double mutant XnGroEL showed an approximately 8-fold increase of Kd in chitin binding assay. Our results demonstrate that X. nematophila secretes an insecticidal GroEL protein with chitin binding activity.

  2. INTEGRAL and XMM-Newton observations towards the unidentified MeV source GRO J1411-64

    CERN Document Server

    Torres, D F; Reimer, O; Barcons, X; Corral, A; Bosch-Ramon, V; Paredes, J M; Romero, G E; Qu, J L; Collmar, W; Schönfelder, V; Butt, Y; Torres, Diego F.; Zhang, Shu; Reimer, Olaf; Barcons, Xavier; Corral, Amalia; Bosch-Ramon, Valenti; Paredes, Josep M.; Romero, Gustavo E.; Qu, Jin Lu; Collmar, Werner; Butt, Yousaf

    2006-01-01

    The COMPTEL unidentified source GRO J1411-64 was observed by INTEGRAL, and its central part, also by XMM-Newton. The data analysis shows no hint for new detections at hard X-rays. The upper limits in flux herein presented constrain the energy spectrum of whatever was producing GRO J1411-64, imposing, in the framework of earlier COMPTEL observations, the existence of a peak in power output located somewhere between 300-700 keV for the so-called low state. The Circinus Galaxy is the only source detected within the 4$\\sigma$ location error of GRO J1411-64, but can be safely excluded as the possible counterpart: the extrapolation of the energy spectrum is well below the one for GRO J1411-64 at MeV energies. 22 significant sources (likelihood $> 10$) were extracted and analyzed from XMM-Newton data. Only one of these sources, XMMU J141255.6-635932, is spectrally compatible with GRO J1411-64 although the fact the soft X-ray observations do not cover the full extent of the COMPTEL source position uncertainty make an...

  3. Eine CarSharing-Zielgruppenanalyse der großen SrV-Vergleichsstädte

    OpenAIRE

    Hahn, Christoph

    2015-01-01

    Due to enormous growth rates during the last couple of years CarSharing has become an interesting field of research. This Master Thesis focuses on the analysis of CarSharing users. For this purpose more than 37.000 participants of the "Große SrV-Vergleichsstädte"-Survey were taken into account. After a short literature review and some general information about the statistical methods, the thesis tries to work out some major characteristics of the typical CarSharing user. It will be shown, tha...

  4. DOE handbook: Tritium handling and safe storage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The DOE Handbook was developed as an educational supplement and reference for operations and maintenance personnel. Most of the tritium publications are written from a radiological protection perspective. This handbook provides more extensive guidance and advice on the null range of tritium operations. This handbook can be used by personnel involved in the full range of tritium handling from receipt to ultimate disposal. Compliance issues are addressed at each stage of handling. This handbook can also be used as a reference for those individuals involved in real time determination of bounding doses resulting from inadvertent tritium releases. This handbook provides useful information for establishing processes and procedures for the receipt, storage, assay, handling, packaging, and shipping of tritium and tritiated wastes. It includes discussions and advice on compliance-based issues and adds insight to those areas that currently possess unclear DOE guidance.

  5. 34 CFR 662.22 - How does the J. William Fulbright Foreign Scholarship Board select fellows?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false How does the J. William Fulbright Foreign Scholarship Board select fellows? 662.22 Section 662.22 Education Regulations of the Offices of the Department of... Foreign Scholarship Board select fellows? (a) The J. William Fulbright Foreign Scholarship Board...

  6. What should a fellow-in-training expect at national cardiovascular conferences? The interventional cardiology fellows' perspective.

    Science.gov (United States)

    Kiramijyan, Sarkis; Didier, Romain; Koifman, Edward; Negi, Smita I

    It has become challenging for cardiovascular fellows-in-training (FIT) to determine which national cardiovascular conference (NCC) to attend given the broad range of meetings and the breadth of information offered. The aim of this study was to report our own experiences of the utility and individual strengths of the NCCs and to further understand the interventional cardiology (IC) FITs' viewpoint regarding the benefits of the individual NCCs. A survey was formulated with questions and scenarios regarding topics deemed to be of highest importance for an IC-FIT. The survey emphasized experiences regarding the utility and benefits of the NCCs, time management, optimization of acquired education, and specific interests in clinical and research topics. The completely anonymous survey was sent via an email format to a total of 234, majority of IC (fourth and fifth years) and a minority of general (third year), FITs. A completed survey response was received from 131 of the fellows (56%). The results demonstrated that the IC-FITs endorsed that the small, focused sub-specialty interventional meetings vs. the large society general meetings were more beneficial in regard to the didactic education offered. In addition, the IC-FITs indicated that pre-planning for the meetings is the most beneficial approach in optimizing one's education and that the caliber of expert faculty, case-based and live-case presentations are among the most important aspects of the meetings. Interventional cardiology FITs prefer the small sub-specialty interventional meetings over the large society general NCCs in regard to the benefits of didactic learning. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. NuSTAR Observations of the Be/X-ray Binary GRO J1008-57 in Outburst

    Science.gov (United States)

    Bellm, Eric; Fuerst, F.; Pottschmidt, K.; Wilms, J.; Boggs, S. E.; Christensen, F.; Craig, W. W.; Hailey, C. J.; Harrison, F.; Stern, D.; Tomsick, J.; Zhang, W.; NuSTAR Science Team

    2013-04-01

    GRO J1008-57 is an HMXB that exhibits regular outbursts due to orbitally-driven accretion onto the neutron star from the Be companion. Spectral analysis of previous bursts have suggested the existence of a cyclotron resonant scattering feature at 88 keV, which, if confirmed as the fundamental line, would indicate the presence of one of the most highly-magnetized accreting neutron stars. In November 2012, GRO J1008 produced a Type II ("giant") burst with peak flux near 1 Crab. NuSTAR observed the outburst for 12 ksec near the peak of emission. We present spectral and timing analysis of GRO J1008 over NuSTAR's 3-79 keV energy band. Considering that the putative 88 keV line could be a harmonic rather than the fundamental, we search for cyclotron lines in the NuSTAR band and discuss implications for models of the system's magnetic field.

  8. Gen IV Materials Handbook Implementation Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rittenhouse, P.; Ren, W.

    2005-03-29

    A Gen IV Materials Handbook is being developed to provide an authoritative single source of highly qualified structural materials information and materials properties data for use in design and analyses of all Generation IV Reactor Systems. The Handbook will be responsive to the needs expressed by all of the principal government, national laboratory, and private company stakeholders of Gen IV Reactor Systems. The Gen IV Materials Handbook Implementation Plan provided here addresses the purpose, rationale, attributes, and benefits of the Handbook and will detail its content, format, quality assurance, applicability, and access. Structural materials, both metallic and ceramic, for all Gen IV reactor types currently supported by the Department of Energy (DOE) will be included in the Gen IV Materials Handbook. However, initial emphasis will be on materials for the Very High Temperature Reactor (VHTR). Descriptive information (e.g., chemical composition and applicable technical specifications and codes) will be provided for each material along with an extensive presentation of mechanical and physical property data including consideration of temperature, irradiation, environment, etc. effects on properties. Access to the Gen IV Materials Handbook will be internet-based with appropriate levels of control. Information and data in the Handbook will be configured to allow search by material classes, specific materials, specific information or property class, specific property, data parameters, and individual data points identified with materials parameters, test conditions, and data source. Details on all of these as well as proposed applicability and consideration of data quality classes are provided in the Implementation Plan. Website development for the Handbook is divided into six phases including (1) detailed product analysis and specification, (2) simulation and design, (3) implementation and testing, (4) product release, (5) project/product evaluation, and (6) product

  9. Confirmation of a high magnetic field in GRO J1008–57

    Energy Technology Data Exchange (ETDEWEB)

    Bellm, Eric C.; Fürst, Felix; Harrison, Fiona A.; Walton, Dominic J. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Pottschmidt, Katja [Center for Space Science and Technology, University of Maryland Baltimore County, Baltimore, MD 21250 (United States); Tomsick, John A.; Boggs, Steven E.; Craig, William W. [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Chakrabarty, Deepto [Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Christensen, Finn E. [DTU Space-National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Hailey, Charles J. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Stern, Daniel [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Wilms, Jörn [Dr. Karl-Remeis-Sternwarte and ECAP, Sternwartstr. 7, D-96049 Bamberg (Germany); Zhang, William W., E-mail: ebellm@caltech.edu [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2014-09-10

    GRO J1008–57 is a high-mass X-ray binary for which several claims of a cyclotron resonance scattering feature near 80 keV have been reported. We use NuSTAR, Suzaku, and Swift data from its giant outburst of 2012 November to confirm the existence of the 80 keV feature and perform the most sensitive search to date for cyclotron scattering features at lower energies. We find evidence for a 78{sub −2}{sup +3} keV line in the NuSTAR and Suzaku data at >4σ significance, confirming the detection using Suzaku alone by Yamamoto et al. A search of both the phase-averaged and phase-resolved data rules out a fundamental at lower energies with optical depth larger than 5% of the 78 keV line. These results indicate that GRO J1008–57 has a magnetic field of 6.7 × 10{sup 12}(1 + z) G, the highest among known accreting pulsars.

  10. Stress and burnout among critical care fellows: preliminary evaluation of an educational intervention

    Directory of Open Access Journals (Sweden)

    Kianoush Kashani

    2015-07-01

    Full Text Available Background: Despite a demanding work environment, information on stress and burnout of critical care fellows is limited. Objectives: To assess 1 levels of burnout, perceived stress, and quality of life in critical care fellows, and 2 the impact of a brief stress management training on these outcomes. Methods: In a tertiary care academic medical center, 58 critical care fellows of varying subspecialties and training levels were surveyed to assess baseline levels of stress and burnout. Twenty-one of the 58 critical care fellows who were in the first year of training at the time of this initial survey participated in a pre-test and 1-year post-test to determine the effects of a brief, 90-min stress management intervention. Results: Based on responses (n=58 to the abbreviated Maslach Burnout Inventory, reported burnout was significantly lower in Asian fellows (p=0.04 and substantially higher among graduating fellows (versus new and transitioning fellows (p=0.02. Among the intervention cohort, burnout did not significantly improve – though two-thirds of fellows reported using the interventional techniques to deal with stressful situations. Fellows who participated in the intervention rated the effectiveness of the course as 4 (IQR=3.75–5 using the 5-point Likert scale. Conclusions: In comparison with the new and transitioning trainees, burnout was highest among graduating critical care fellows. Although no significant improvements were found in first-year fellows’ burnout scores following the single, 90-min training intervention, participants felt the training did provide them with tools to apply during stressful situations.

  11. Postgraduate Education in Quality Improvement Methods: Initial Results of the Fellows' Applied Quality Training (FAQT) Curriculum.

    Science.gov (United States)

    Winchester, David E; Burkart, Thomas A; Choi, Calvin Y; McKillop, Matthew S; Beyth, Rebecca J; Dahm, Phillipp

    2016-06-01

    Training in quality improvement (QI) is a pillar of the next accreditation system of the Accreditation Committee on Graduate Medical Education and a growing expectation of physicians for maintenance of certification. Despite this, many postgraduate medical trainees are not receiving training in QI methods. We created the Fellows Applied Quality Training (FAQT) curriculum for cardiology fellows using both didactic and applied components with the goal of increasing confidence to participate in future QI projects. Fellows completed didactic training from the Institute for Healthcare Improvement's Open School and then designed and completed a project to improve quality of care or patient safety. Self-assessments were completed by the fellows before, during, and after the first year of the curriculum. The primary outcome for our curriculum was the median score reported by the fellows regarding their self-confidence to complete QI activities. Self-assessments were completed by 23 fellows. The majority of fellows (15 of 23, 65.2%) reported no prior formal QI training. Median score on baseline self-assessment was 3.0 (range, 1.85-4), which was significantly increased to 3.27 (range, 2.23-4; P = 0.004) on the final assessment. The distribution of scores reported by the fellows indicates that 30% were slightly confident at conducting QI activities on their own, which was reduced to 5% after completing the FAQT curriculum. An interim assessment was conducted after the fellows completed didactic training only; median scores were not different from the baseline (mean, 3.0; P = 0.51). After completion of the FAQT, cardiology fellows reported higher self-confidence to complete QI activities. The increase in self-confidence seemed to be limited to the applied component of the curriculum, with no significant change after the didactic component.

  12. Palliative care experience of US adult nephrology fellows: a national survey.

    Science.gov (United States)

    Shah, Hitesh H; Monga, Divya; Caperna, April; Jhaveri, Kenar D

    2014-02-01

    Palliative care (PC) training and experience of United States (US) adult nephrology fellows was not known. It was also not clear whether nephrology fellows in the US undergo formal training in PC medicine during fellowship. To gain a better understanding of the clinical training and experience of US adult nephrology fellows in PC medicine, we conducted a national survey in March 2012. An anonymous on-line survey was sent to US adult nephrology fellows via nephrology fellowship training program directors. Fellows were asked several PC medicine experience and training questions. A total of 105 US adult nephrology fellows responded to our survey (11% response rate). Majority of the respondents (94%) were from university-based fellowship programs. Over two-thirds (72%) of the fellows had no formal PC medicine rotation during their medical school. Half (53%) of the respondents had no formal PC elective experience during residency. Although nearly 90% of the fellows had a division or department of PC medicine at their institution, only 46.9% had formal didactic PC medicine experience. Over 80% of the respondent's program did not offer formal clinical training or rotation in PC medicine during fellowship. While 90% of the responding fellows felt most comfortable with either writing dialysis orders in the chronic outpatient unit, seeing an ICU consult or writing continuous dialysis orders in the ICU, only 35% of them felt most comfortable "not offering" dialysis to a patient in the ICU with multi-organ failure. Nearly one out of five fellows surveyed felt obligated to offer dialysis to every patient regardless of benefit. Over two-thirds (67%) of the respondents thought that a formal rotation in PC medicine during fellowship would be helpful to them. To enhance clinical competency and confidence in PC medicine, a formal PC rotation during fellowship should be highly considered by nephrology training community.

  13. National association of broadcasters engineering handbook NAB engineering handbook

    CERN Document Server

    Jones, Graham A; Osenkowsky, Thomas G; Williams, Edmund A

    2013-01-01

    The NAB Engineering Handbook provides detailed information on virtually every aspect of the broadcast chain, from news gathering, program production and postproduction through master control and distribution links to transmission, antennas, RF propagation, cable and satellite. Hot topics covered include HD Radio, HDTV, 2 GHz broadcast auxiliary services, EAS, workflow, metadata, digital asset management, advanced video and audio compression, audio and video over IP, and Internet broadcasting. A wide range of related topics that engineers and managers need to understand are also covered, includ

  14. MESSENGER Educator Fellows Taking the Nation on a Ride to the Innermost Planet

    Science.gov (United States)

    Vanhala, H. A.; Goldstein, J. J.; Chapman, C. R.; Edmonds, J. P.; Hallau, K. G.; Hirshon, B.; Weir, H. M.; Solomon, S. C.

    2011-12-01

    Exploration of the mysterious planet Mercury offers an unprecedented opportunity for teachers, students, and citizens to tag along for the ride, and the MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) Educator Fellows are making sure classrooms across the U.S. are treated to quite a show. The Fellows, a nationally selected team of 30 master science educator volunteers, conduct workshops to teachers on how to bring educational materials developed in support of the mission into the classroom. The goal of the program is to provide teachers and school districts with exceptional educational materials and professional development strongly tied to the space science curriculum, and the materials are designed to inspire the next generation of America's scientists and engineers through NASA missions. Since the program's inception in 2003, more than 17,000 educators have been trained by the Fellows. On the basis of data gathered from the Fellows, this figure could translate to over two million student experiences. The success of the Fellowship program can also be gauged by determining how well it has maintained its volunteer corps over the years. The Fellows, selected to the program through a national announcement of opportunity every two years, reflect a geographically and institutionally diverse mix of individuals from a variety of settings such as science centers, museums, school districts, and universities. The Fellows sign up to the program for two years at a time, and at the end of their term they have the option to reapply. To keep the number of Fellows at 30 in each cadre, new Fellows are recruited to replace those who have retired. The current, fourth cadre of Fellows includes 30 individuals in 19 states and territories. Of these, seven have been in the program since the first cadre, and the other 23 include Fellows from the second, third, and fourth recruitment campaigns in 2006, 2008, and 2010. The current cadre is conducting its work

  15. The composite materials handbook (MIL handbook 17). Volume 1: Guidelines for characterization of structural materials

    Energy Technology Data Exchange (ETDEWEB)

    1999-01-01

    The Composite Materials Handbook (MIL Handbook 17) is THE source for data and usage guidelines for current and emerging polymer matrix composite materials. It provides the tools needed to design and fabricate end items from polymer matrix composite materials and offers guidelines for how these data should be generated and used. The Handbook is a comprehensive guide of composites technology and engineering, an area that is advancing and changing rapidly. Volume 1 explains the methods by which materials property data should be obtained, and criteria for their acceptance for publication in the Handbook.

  16. Security-by-design handbook.

    Energy Technology Data Exchange (ETDEWEB)

    Snell, Mark Kamerer; Jaeger, Calvin Dell; Scharmer, Carol; Jordan, Sabina Erteza; Tanuma, Koji [Japan Atomic Energy Agency, Tokai-mura, Ibaraki, Japan; Ochiai, Kazuya [Japan Atomic Energy Agency, Tokai-mura, Ibaraki, Japan; Iida, Toru [Japan Atomic Energy Agency, Tokai-mura, Ibaraki, Japan

    2013-01-01

    This document is a draft SecuritybyDesign (SeBD) handbook produced to support the Work Plan of the Nuclear Security Summit to share best practices for nuclear security in new facility design. The Work Plan calls on States to %E2%80%9Cencourage nuclear operators and architect/engineering firms to take into account and incorporate, where appropriate, effective measures of physical protection and security culture into the planning, construction, and operation of civilian nuclear facilities and provide technical assistance, upon request, to other States in doing so.%E2%80%9D The materials for this document were generated primarily as part of a bilateral project to produce a SeBD handbook as a collaboration between the Japan Atomic Energy Agency (JAEA) Nuclear Nonproliferation Science and Technology Center and Sandia National Laboratories (SNL), which represented the US Department Energy (DOE) National Nuclear Security Administration (NNSA) under a Project Action Sheet PASPP04. Input was also derived based on tours of the Savannah River Site (SRS) and Japan Nuclear Fuel Limited (JNFL) Rokkasho Mixed Oxide Fuel fabrication facilities and associated project lessonslearned. For the purposes of the handbook, SeBD will be described as the systemlevel incorporation of the physical protection system (PPS) into a new nuclear power plant or nuclear facility resulting in a PPS design that minimizes the risk of malicious acts leading to nuclear material theft; nuclear material sabotage; and facility sabotage as much as possible through features inherent in (or intrinsic to) the design of the facility. A fourelement strategy is presented to achieve a robust, durable, and responsive security system.

  17. Handbook of Collaborative Management Research

    CERN Document Server

    Shani, A B Rami B; Pasmore, William A A; Stymne, Dr Bengt; Adler, Niclas

    2007-01-01

    This handbook provides the latest thinking, methodologies and cases in the rapidly growing area of collaborative management research. What makes collaborative management research different is its emphasis on creating a close partnership between scholars and practitioners in the search for knowledge concerning organizations and complex systems. In the ideal situation, scholars and their managerial partners would work together to define the research focus, develop the methods to be used for data collection, participate equally in the analysis of data, and work together in the application and dis

  18. Handbook of power systems I

    CERN Document Server

    Pardalos, P M; Pereira, Mario V; Iliadis, Niko A

    2010-01-01

    Energy is one of the world's most challenging problems, and power systems are an important aspect of energy-related issues. The Handbook of Power Systems contains state-of-the-art contributions on power systems modeling. In particular, it covers topics like operation planning, expansion planning, transmission and distribution modelling, computing technologies in energy systems, energy auctions, risk management, market regulation, stochastic programming in energy, and forecasting in energy. The book is separated into nine sections, which cover the most important areas of energy systems. The con

  19. Handbook for Designing MMOD Protection

    Science.gov (United States)

    Arnold, Jim; Christiansen, Eric L.; Davis, Alan; Hyde, James; Lear, Dana; Liou, J.C.; Lyons, Frankel; Prior, Thomas; Studor, George; Ratliff, Martin; hide

    2009-01-01

    Spacecraft are subject to micro-meteoroid and orbital debris (MMOD) impact damage which have the potential to degrade performance, shorten the mission, or result in catastrophic loss of the vehicle. Specific MMOD protection requirements are established by NASA for each spacecraft early in the program/project life, to ensure the spacecraft meets desired safety and mission success goals. Both the design and operations influences spacecraft survivability in the MMOD environment, and NASA considers both in meeting MMOD protection requirements. The purpose of this handbook is to provide spacecraft designers and operations personnel with knowledge gained by NASA in implementing effective MMOD protection for the International Space Station, Space Shuttle, and various science spacecraft. It has been drawn from a number of previous publications [10-14], as well as new work. This handbook documents design and operational methods to reduce MMOD risk. In addition, this handbook describes tools and equations needed to design proper MMOD protection. It is a living report, in that it will be updated and re-released periodically in future with additional information. Providing effective and efficient MMOD protection is essential for ensuring safe and successful operations of spacecraft and satellites. A variety of shields protect crew modules, external pressurized vessels and critical equipment from MMOD on the International Space Station (ISS). Certain Space Shuttle Orbiter vehicle systems are hardened from MMOD impact, and operational rules are established to reduce the risk from MMOD (i.e., flight attitudes are selected and late inspection of sensitive thermal protection surfaces are conducted to reduce MMOD impacts). Science spacecraft include specific provisions to meet MMOD protection requirements in their design (for example, Stardust & GLAST). Commercial satellites such as Iridium and Bigelow Aerospace Genesis spacecraft incorporate MMOD protection. The development of low

  20. The mobile application hacker's handbook

    CERN Document Server

    Chell, Dominic; Colley, Shaun; Whitehouse, Ollie

    2015-01-01

    See your app through a hacker's eyes to find the real sources of vulnerability The Mobile Application Hacker's Handbook is a comprehensive guide to securing all mobile applications by approaching the issue from a hacker's point of view. Heavily practical, this book provides expert guidance toward discovering and exploiting flaws in mobile applications on the iOS, Android, Blackberry, and Windows Phone platforms. You will learn a proven methodology for approaching mobile application assessments, and the techniques used to prevent, disrupt, and remediate the various types of attacks. Coverage i

  1. The Maplin electronic circuits handbook

    CERN Document Server

    Tooley, Michael

    2015-01-01

    The Maplin Electronic Circuits Handbook provides pertinent data, formula, explanation, practical guidance, theory and practical guidance in the design, testing, and construction of electronic circuits. This book discusses the developments in electronics technology techniques.Organized into 11 chapters, this book begins with an overview of the common types of passive component. This text then provides the reader with sufficient information to make a correct selection of passive components for use in the circuits. Other chapters consider the various types of the most commonly used semiconductor

  2. Computer and information security handbook

    CERN Document Server

    Vacca, John R

    2012-01-01

    The second edition of this comprehensive handbook of computer and information security provides the most complete view of computer security and privacy available. It offers in-depth coverage of security theory, technology, and practice as they relate to established technologies as well as recent advances. It explores practical solutions to many security issues. Individual chapters are authored by leading experts in the field and address the immediate and long-term challenges in the authors' respective areas of expertise. The book is organized into 10 parts comprised of 70 contributed

  3. Newnes short wave listening handbook

    CERN Document Server

    Pritchard, Joe

    2013-01-01

    Newnes Short Wave Listening Handbook is a guide for starting up in short wave listening (SWL). The book is comprised of 15 chapters that discuss the basics and fundamental concepts of short wave radio listening. The coverage of the text includes electrical principles; types of signals that can be heard in the radio spectrum; and using computers in SWL. The book also covers SWL equipment, such as receivers, converters, and circuits. The text will be of great use to individuals who want to get into short wave listening.

  4. Reeds diesel engine troubleshooting handbook

    CERN Document Server

    Pickthall, Barry

    2013-01-01

    Most diesel engines will develop a problem at some point in their lives, but armed with the right knowledge a skipper needn't worry. The Reeds Diesel Engine Troubleshooting Handbook is a compact, pocket-sized guide to finding solutions to all of the most common engine problems, and many of the less common ones too. The perfect format for quick reference on board, this book will help skippers fix troublesome engines themselves, avoiding costly engineer fees if the problem is simple to sort out, or enabling an emergency patch-up for a more serious problem until they can get back to port. Each to

  5. Handbook of ecotoxicology, second edition

    Science.gov (United States)

    Hoffman, David J.; Rattner, Barnett A.; Burton, G. Allen; Cairns, John

    2003-01-01

    Handbook of Ecotoxicology, Second Edition focuses on toxic substances and how they affect ecosystems worldwide. It presents methods for quantifying and measuring ecotoxicological effects in the field and in the lab, as well as methods for estimating, predicting, and modeling in ecotoxicology studies. Completely revised and updated with 18 new chapters, this second edition includes contributions from over 75 international experts. Also, a Technical Review Board reviewed all manuscripts for accuracy and currency. This authoritative work is the definitive reference for students, researchers, consultants, and other professionals in the environmental sciences, toxicology, chemistry, biology, and ecology - in academia, industry, and government.

  6. Technology handbook of vacuum physics

    CERN Document Server

    Beck, A H

    2013-01-01

    Handbook of Vacuum Physics, Volume 3: Technology is part of a series of publications that presents articles featuring the whole spectrum of vacuum physics. This particular volume presents materials that deal with technology concerns in vacuum mechanics. The first material talks about the utilization of ceramic materials in the construction of vacuum devices. The next paper details the application of vacuum physics in soldering and brazing process. The last article deals with the utilization of vacuum technology in high frequency heating. The book will be of great use to professionals involved

  7. Handbook of data intensive computing

    CERN Document Server

    Furht, Borko

    2011-01-01

    Data Intensive Computing refers to capturing, managing, analyzing, and understanding data at volumes and rates that push the frontiers of current technologies. The challenge of data intensive computing is to provide the hardware architectures and related software systems and techniques which are capable of transforming ultra-large data into valuable knowledge. Handbook of Data Intensive Computing is written by leading international experts in the field. Experts from academia, research laboratories and private industry address both theory and application. Data intensive computing demands a fund

  8. Oxford handbook of sound studies

    CERN Document Server

    Pinch, Trevor

    2011-01-01

    Written by the world's leading scholars and researchers in the emerging field of sound studies, The Oxford Handbook of Sound Studies offers new and fully engaging perspectives on the significance of sound in its material and cultural forms. The book considers sounds and music as experienced in such diverse settings as shop floors, laboratories, clinics, design studios, homes, and clubs, across an impressively broad range of historical periods and national and cultural contexts.Science has traditionally been understood as a visual matter, a study which has historically been undertaken with opti

  9. Handbook of algebra Vol. 1

    CERN Document Server

    1996-01-01

    Handbook of Algebra defines algebra as consisting of many different ideas, concepts and results. Even the nonspecialist is likely to encounter most of these, either somewhere in the literature, disguised as a definition or a theorem or to hear about them and feel the need for more information. Each chapter of the book combines some of the features of both a graduate-level textbook and a research-level survey. This book is divided into eight sections. Section 1A focuses on linear algebra and discusses such concepts as matrix functions and equations and random matrices. Section 1B cover linear d

  10. The Weibull distribution a handbook

    CERN Document Server

    Rinne, Horst

    2008-01-01

    The Most Comprehensive Book on the SubjectChronicles the Development of the Weibull Distribution in Statistical Theory and Applied StatisticsExploring one of the most important distributions in statistics, The Weibull Distribution: A Handbook focuses on its origin, statistical properties, and related distributions. The book also presents various approaches to estimate the parameters of the Weibull distribution under all possible situations of sampling data as well as approaches to parameter and goodness-of-fit testing.Describes the Statistical Methods, Concepts, Theories, and Applications of T

  11. Transformer and inductor design handbook

    CERN Document Server

    McLyman, Colonel Wm T

    2011-01-01

    With its practical approach to design, Transformer and Inductor Design Handbook, Fourth Edition distinguishes itself from other books by presenting information and guidance that is shaped primarily by the user's needs and point of view. Expanded and revised to address recent industry developments, the fourth edition of this classic reference is re-organized and improved, again serving as a constant aid for anyone seeking to apply the state of the art in transformer and inductor design. Carefully considering key factors such as overall system weight, power conversion efficiency, and cost, the a

  12. Mass Media Fellow Westley spends summer publishing in Newsweek

    Science.gov (United States)

    Leifert, Harvey

    If you are a subscriber to Newsweek, you probably remember these stories from the past few months: “Vaccine Revolution,” “Aliens Invade America!,” “A Gymnast's Long Fall,” “Is AIDS Forever?,” and a cover story, “Science Finds God.” They all had something in common, aside from their science focus: at the end of each article was the credit line, “With Marian Westley.” In addition, a story titled “A Long, Wacky Summer,” on recent weather patterns, carried Marian Westley's byline. Who, you may have wondered, is this Marian Westley, who reports with equal aplomb on matters as diverse as epidemiology, meteorology, the predations of nonnative plant species, and the interface between scientists and theologians? Actually, Westley is a graduate student in biological oceanography at the University of Hawaii and a member of AGU. She spent the summer of 1998 as the AAAS/AGU Mass Media Fellow at Newsweek in New York.

  13. A pilot study of palliative medicine fellows' hospice home visits.

    Science.gov (United States)

    Shoemaker, Laura K; Aktas, Aynur; Walsh, Declan; Hullihen, Barbara; Khan, Mohammed I Ahmed; Russell, Kraig M; Davis, Mellar P; Lagman, Ruth; LeGrand, Susan

    2012-12-01

    This was a prospective descriptive study of hospice physician home visits (HVs) conducted by Hospice and Palliative Medicine Fellows. Our objectives were 1) to improve our knowledge of hospice care at home by describing physician HVs 2) to identify the indications for physician HVs and the problems addressed during the HV. Data was collected on 58 consecutive patients using a standardized form completed before and after the home visit. More than half of the persons were women. Most were Caucasian. Median age was 75 years; 57% had cancer; 77% were do-not-resuscitate. 76% HV occurred in the home. The median visit duration was 60 minutes; median travel distance and time 25 miles and 42 minutes, respectively. A hospice nurse case manager was present in 95%. The most common issues addressed during HVs were: health education, symptom management, and psychosocial support. Medication review was prominent. Physicians identified previously unreported issues. Symptom control was usually pain, although 27 symptoms were identified. Medications were important; all home visits included drug review and two thirds drug change. Physicians had unique responsibilities and identified important issues in the HV. Physicians provided both education and symptom management. Physician HVs are an important intervention. HVs were important in continuity of care, however, time-consuming, and incurred considerable travel, and professional time and costs.

  14. Audiology: student perception of preceptor and fellow student ethics.

    Science.gov (United States)

    Franklin, Clifford; Vesely, Brian; White, Letitia; Mantie-Kozlowski, Alana; Franklin, Clay

    2014-01-01

    Health care professionals are expected to uphold high ethical standards. Recently, ethical practices in health care have received increased scrutiny and study in an effort to ensure that clinicians meet such high ethical standards in serving their patients and clients. The American Academy of Audiology's Code of Ethics establishes professional standards that allow for the proper discharge of an audiologist's responsibilities while maintaining the integrity of the profession. Under this code, student academy members are included and required to abide by the code, the same as practicing members. The code is composed of a preamble and eight principles. The present study provides an overview of students' perceptions across a broad spectrum of ethical topics governing our profession. Specifically, this study examined audiology students' perceptions of preceptor ethics relating to these eight principles using an online survey. Responses were collected from 143 of 600 audiology students contacted and indicated that they believed that their preceptors consistently followed each of the eight principles. Results also indicated that students believe fellow students also behave ethically and that it is the primary responsibility of academic faculty, not preceptors, to teach ethics. It can be concluded that preceptors are perceived by their students to be acting with high ethical standards. However, more research and discussion may be needed to determine who should teach these ethics to students.

  15. Attitudes toward neuroscience education among psychiatry residents and fellows.

    Science.gov (United States)

    Fung, Lawrence K; Akil, Mayada; Widge, Alik; Roberts, Laura Weiss; Etkin, Amit

    2014-04-01

    The purpose of this study is to assess the attitudes of psychiatry trainees toward neuroscience education in psychiatry residency and subsequent training in order to inform neuroscience education approaches in the future. This online survey was designed to capture demographic information, self-assessed neuroscience knowledge, attitudes toward neuroscience education, preferences in learning modalities, and interest in specific neuroscience topics. Volunteers were identified through the American Psychiatric Association, which invited 2,563 psychiatry trainees among their members. Four hundred thirty-six trainees completed the survey. Nearly all agreed that there is a need for more neuroscience education in psychiatry residency training (94%) and that neuroscience education could help destigmatize mental illness (91%). Nearly all (94%) expressed interest in attending a 3-day course on neuroscience. Many neuroscience topics and modes of learning were viewed favorably by participants. Residents in their first 2 years of training expressed attitudes similar to those of more advanced residents and fellows. Some differences were found based on the level of interest in a future academic role. This web-based study demonstrates that psychiatry residents see neuroscience education as important in their training and worthy of greater attention. Our results suggest potential opportunities for advancing neuroscience education.

  16. Detection of Keratoconus in Clinically and Algorithmically Topographically Normal Fellow Eyes Using Epithelial Thickness Analysis

    Science.gov (United States)

    Reinstein, Dan Z.; Archer, Timothy J.; Urs, Raksha; Gobbe, Marine; RoyChoudhury, Arindam; Silverman, Ronald H.

    2017-01-01

    PURPOSE To assess the effectiveness of a keratoconus-detection algorithm derived from Artemis very high-frequency (VHF) digital ultrasound (ArcScan Inc., Morrison, CO) epithelial thickness maps in the fellow eye from a series of patients with unilateral keratoconus. METHODS The study included 10 patients with moderate to advanced keratoconus in one eye but a clinically and algorithmically topographically normal fellow eye. VHF digital ultrasound epithelial thickness data were acquired and a previously developed classification model was applied for identification of keratoconus to the clinically normal fellow eyes. Pentacam (Oculus Optikgeräte, Wetzlar, Germany) Belin-Ambrósio Display (BAD) data (5 of 10 eyes), and Orbscan (Bausch & Lomb, Rochester, NY) SCORE data (9 of 10 eyes) were also evaluated. RESULTS Five of the 10 fellow eyes were classified as keratoconic by the VHF digital ultrasound epithelium model. Five of 9 fellow eyes were classified as keratoconic by the SCORE model. For the 5 fellow eyes with Pentacam and VHF digital ultrasound data, one was classified as keratoconic by the VHF digital ultrasound model, one (different) eye by a combined VHF digital ultrasound and Pentacam model, and none by BAD-D alone. CONCLUSIONS Under the assumption that keratoconus is a bilateral but asymmetric disease, half of the ‘normal’ fellow eyes could be found to have keratoconus using epithelial thickness maps. The Orbscan SCORE or the combination of topographic BAD criteria with epithelial maps did not perform better. PMID:26544561

  17. Training gastroenterology fellows to perform gastric polypectomy using a novel ex vivo model

    Institute of Scientific and Technical Information of China (English)

    Ming-Jen Chen; Ching-Chung Lin; Chia-Yuan Liu; Chih-Jen Chen; Chen-Wang Chang; Ching-Wei Chang; Chien-Wei Lee; Shou-Chuan Shih; Horng-Yuan Wang

    2011-01-01

    AIM: To evaluate the effect of hands-on training of gastroenterology fellows in gastric polypectomy using an ex vivo simulator.METHODS: Eight gastroenterology fellows at Mackay Memorial Hospital, Taipei were evaluated in gastric polypectomy techniques using a pig stomach with artificial polyps created by a rubber band ligation device. The performance of four second year (year-2) fellows who had undergone one year of clinical training was compared with that of four first year (year-1) fellows both before and after a 4-h workshop using the ex vivo simulator. The workshop allowed for hands-on training in the removal of multiple artificial polyps and the placement of hemoclips at the excision site. Evaluation included observation of technical skills, procedure time, and the fellows' confidence scale.RESULTS: One week after the workshop, the year-1 fellows were re-evaluated and had significantly improved mean performance scores (from 17.9 ± 1.8 to 22.5 ± 0.7), confidence scale (from 4.5 ± 1.0 to 7.8 ± 0.5) and procedure time (from 615.0 ± 57.4 s to 357.5 ± 85.0 s) compared with their baseline performance. After 4 h of training using the ex vivo simulator, the skills of the year-1 fellows were statistically similar to those of the year-2 fellows.CONCLUSION: Use of this ex vivo simulator significantly improved the endoscopic gastric polypectomy skills of gastroenterology fellows who had not had previous clinical training in gastric polypectomy.

  18. ABCs of Safety and Quality for the Pediatric Resident and Fellow.

    Science.gov (United States)

    Mathias, Emily; Sethuraman, Usha

    2016-04-01

    The role of resident and fellow trainees in patient-centered improvement processes is critical to a health care system's success. There is a growing impetus to incorporate patient safety and quality improvement into the educational framework of physicians in training. As part of the Next Accreditation System, practice-based learning and improvement and systems-based practice domains mandate that residents and fellows be assessed on their ability to enhance the quality of care and advocate for patient safety. Best practices for incorporating quality improvement and patient safety into the curriculum of residents and fellows remains an area of interest for educators. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Handbook of human resources management

    CERN Document Server

    2016-01-01

    Human resources topics are gaining more and more strategic importance in modern business management. Only those companies that find the right answers to the following questions have a sustainable basis for their future success: - How can we attract and select the right talent for our teams? - How can we develop the skills and behaviors which are key for our business? - How can we engage and retain the talent we need for our future? While most other management disciplines have their standards and procedures, Human Resources still lacks a broadly accepted basis for its work. Both the structured collection of reflected real-life experience and the multi-perspective view support readers in making informed and well-balanced decisions. With this handbook, Springer provides a landmark reference work on today’s HR management, based on the combined experience of more than 85 globally selected HR leaders and HR experts. Rather than theoretical discussions about definitions, the handbook focuses on sharing practical e...

  20. Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.

    OpenAIRE

    Mizushima, T.; Matsuo, M.; Sekimizu, K

    1997-01-01

    Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to those required for DNA relaxation and much higher than those required for cell death.

  1. Predominant recognition of species-specific determinants of the GroES homologues from Mycobacterium leprae and M. tuberculosis

    NARCIS (Netherlands)

    Chua-Intra, B.; Ivanyi, J.; Hills, A.; Thole, J.; Moreno, C.; Vordermeier, H.M.

    1998-01-01

    The Mycobacterium leprae and M. tuberculosis 10000 MW heat-shock protein homologues of GroES have previously been identified as major immunogens for human T cells. We used synthetic peptides to characterize the determinants recognized by murine T cells. The findings suggest that, despite 90% sequenc

  2. Simultaneous NuSTAR/Chandra Observations of The Bursting Pulsar GRO J1744-28 During Its Third Reactivation

    DEFF Research Database (Denmark)

    Younes, G.; Kouveliotou, C.; Grefenstette, B. W.

    2015-01-01

    We report on a 10 ks simultaneous Chandra/High Energy Transmission Grating (HETG)-Nuclear Spectroscopic Telescope Array (NuSTAR) observation of the Bursting Pulsar, GRO J1744-28, during its third detected outburst since discovery and after nearly 18 yr of quiescence. The source is detected up to ...

  3. Assessing Reliability and Validity of the "GroPromo" Audit Tool for Evaluation of Grocery Store Marketing and Promotional Environments

    Science.gov (United States)

    Kerr, Jacqueline; Sallis, James F.; Bromby, Erica; Glanz, Karen

    2012-01-01

    Objective: To evaluate reliability and validity of a new tool for assessing the placement and promotional environment in grocery stores. Methods: Trained observers used the "GroPromo" instrument in 40 stores to code the placement of 7 products in 9 locations within a store, along with other promotional characteristics. To test construct validity,…

  4. Discovery of a non-blazar $\\gamma$-ray transient near the Galactic plane GRO J1838-04

    CERN Document Server

    Tavani, M; Mattox, J R; Halpern, J; Thompson, D J; Kanbach, G; Hermsen, W; Zhang, S N; Foster, R S

    1997-01-01

    We report the discovery of a remarkable gamma-ray transient source near the Galactic plane, GRO J1838-04. This source was serendipitously discovered by EGRET in June 1995 with a peak intensity of 4 E(-6) ph/cm/cm/s (for photon energies larger than 100 MeV) and a 5.9 sigma significance. At that time, GRO J1838-04 was the second brightest gamma-ray source in the sky. A subsequent EGRET pointing in late September 1995 detected the source at a flux smaller than its peak value by a factor of 7. We determined that no radio-loud spectrally-flat blazar is within the error box of GRO J1838-04. We discuss the origin of the \\ggg-ray transient source and show that interpretations in terms of AGNs or isolated pulsars are highly problematic. GRO J1838-04 provides strong evidence for the existence of a new class of variable gamma-ray sources.

  5. Effects of the prebiotics GroBiotic-A and inulin on the intestinal microbiota of red drum, Sciaenops ocellatus

    Science.gov (United States)

    Two separate feeding trials examined the effects of dietary supplementation of the prebiotics GroBiotic®-A and inulin on growth performance and gastrointestinal tract microbiota of the red drum Sciaenops ocellatus. In the first feeding trial, fishmeal-based diets without prebiotics or supplemented ...

  6. The handbook of forensic psychopathology and treatment

    NARCIS (Netherlands)

    Cima, M.

    2016-01-01

    The Handbook of Forensic Psychopathology and Treatment explores the relationship between psychopathology and criminal behaviour in juveniles and adults. It provides a detailed explanation of the developmental pathway from the process of increasing criminal behaviour and becoming a forensic patient,

  7. Handbook for value-impact assessment

    Energy Technology Data Exchange (ETDEWEB)

    Heaberlin, S.W.; Burnham, J.B.; Gallucci, R.H.V.; Mullen, M.F.; Nesse, R.J.; Nieves, L.A.; Tawil, J.J.; Triplett, M.B.; Weakley, S.A.; Wusterbarth, A.R.

    1983-12-01

    The basic purpose of this handbook is to document a set of systematic procedures for providing information that can be used in performing value-impact assessments of Nuclear Regulatory Commission (NRC) regulatory actions. The handbook describes a structured but flexible process for performing the assessment. Chapter 1 is an introduction to the value-impact assessment process. Chapter 2 describes the attributes most frequently affected by proposed NRC actions, provides guidance concerningthe appropriate level of effort to be devoted to the assessment, suggests a standard format for documenting the assessment, and discusses the treatment of uncertainty. Chapter 3 contains detailed methods for evaluating each of the attributes affected by a regulatory action. The handbook has five appendixes containing background information, technical data, and example applications of the value-impact assessment procedures. This edition of the handbook focuses primarily on assessing nuclear power reactor safety issues.

  8. Handbook of political citizenship and social movements

    NARCIS (Netherlands)

    van der Heijden, H.A.

    2014-01-01

    This Handbook uniquely collates the results of several decades of academic research in these two important fields. The expert contributions successively address the different forms of political citizenship and current approaches and recent developments in social movement studies. Salient social

  9. The Sage handbook of multilevel modeling

    CERN Document Server

    Scott, Marc A; Marx, Brian D

    2013-01-01

    Leading contributors combine practical pieces with overviews of the state of the art in the field, making this handbook essential reading for any student or researcher looking to apply multilevel techniques in their own research

  10. EXHIBIT OF EMPACT ESTUARY MONITORING HANDBOOKS

    Science.gov (United States)

    Related EMPACT documents were displayed at the National Estuary Day Celebration held in Washington, DC, September 30-Octuber 4, 2002. The estuary monitoring technology transfer handbooks displayed were prepared based on information and monitoring technologies developed from selec...

  11. Landfill Gas Energy Project Development Handbook

    Science.gov (United States)

    View handbook that provides an overview of LFG energy project development guidance and presents the technological, economic and regulatory considerations that affect the feasibility and success of these projects.

  12. Materials data handbook, Inconel alloy 718

    Science.gov (United States)

    Sessler, J.; Weiss, V.

    1967-01-01

    Materials data handbook on Inconel alloy 718 includes data on the properties of the alloy at cryogenic, ambient, and elevated temperatures and other pertinent engineering information required for the design and fabrication of components and equipment utilizing this alloy.

  13. Handbook of offshore oil and gas operations

    National Research Council Canada - National Science Library

    Speight, James G

    2015-01-01

    Handbook of Offshore Oil and Gas Operations is an authoritative source providing extensive up-to-date coverage of the technology used in the exploration, drilling, production, and operations in an offshore setting...

  14. Handbook on modelling for discrete optimization

    CERN Document Server

    Pitsoulis, Leonidas; Williams, H

    2006-01-01

    The primary objective underlying the Handbook on Modelling for Discrete Optimization is to demonstrate and detail the pervasive nature of Discrete Optimization. While its applications cut across an incredibly wide range of activities, many of the applications are only known to specialists. It is the aim of this handbook to correct this. It has long been recognized that "modelling" is a critically important mathematical activity in designing algorithms for solving these discrete optimization problems. Nevertheless solving the resultant models is also often far from straightforward. In recent years it has become possible to solve many large-scale discrete optimization problems. However, some problems remain a challenge, even though advances in mathematical methods, hardware, and software technology have pushed the frontiers forward. This handbook couples the difficult, critical-thinking aspects of mathematical modeling with the hot area of discrete optimization. It will be done in an academic handbook treatment...

  15. The Oxford handbook of economic inequality. - Paperback

    NARCIS (Netherlands)

    Salverda, W.; Nolan, B.; Smeeding, T.M.

    2011-01-01

    The Oxford Handbook of Economic Inequality presents a challenging analysis of economic inequality, focusing primarily on economic inequality in highly-developed countries. This comprehensive and authoritative volume contains twenty-seven original contributions on topics ranging from gender to

  16. Arkansas State University Beebe Branch Faculty Handbook.

    Science.gov (United States)

    Arkansas State Univ., Beebe.

    Arkansas State University Beebe Branch provides a liberal arts oriented program for traditional and nontraditional students. Its faculty handbook contains institutional goals, description of responsibilities of administrative officers and faculty committees, faculty employment policies, and administrative and instructional policies. The…

  17. Security Testing Handbook for Banking Applications

    CERN Document Server

    Doraiswamy, Arvind; Kapoor, Nilesh

    2009-01-01

    Security Testing Handbook for Banking Applications is a specialised guide to testing a wide range of banking applications. The book is intended as a companion to security professionals, software developers and QA professionals who work with banking applications.

  18. Handbook of digital signal processing engineering applications

    CERN Document Server

    1987-01-01

    FROM THE PREFACE: Many new useful ideas are presented in this handbook, including new finite impulse response (FIR) filter design techniques, half-band and multiplierless FIR filters, interpolated FIR (IFIR) structures, and error spectrum shaping.

  19. SIMULTANEOUS FITS IN ISIS ON THE EXAMPLE OF GRO J1008–57

    Directory of Open Access Journals (Sweden)

    M. Kühnel

    2015-04-01

    Full Text Available Parallel computing and steadily increasing computation speed have led to a new tool for analyzing multiple datasets and datatypes: fitting several datasets simultaneously.  With this technique, physically connected parameters of individual data can be treated as a single parameter by implementing this connection directly into the fit. We discuss the terminology, implementation, and possible issues of simultaneous fits based on the Interactive Spectral Interpretation System (ISIS X-ray data analysis tool. While all data modeling tools in X-ray astronomy in principle allow data to be fitted individually from multiple data sets, the syntax used in these tools is not often well suited for this task. Applying simultaneous fits to the transient X-ray binary GRO J1008–57, we find that the spectral shape is only dependent on X-ray flux. We determine time independent parameters e.g., the folding energy Efold, with unprecedented precision.

  20. Simultaneous fits in ISIS on the example of GRO J1008-57

    CERN Document Server

    Kühnel, Matthias; Kreykenbohm, Ingo; Schwarm, Fritz-Walter; Grossberger, Christoph; Dauser, Thomas; Pottschmidt, Katja; Ferrigno, Carlo; Rothschild, Richard E; Klochkov, Dmitry; Staubert, Rüdiger; Wilms, Jörn

    2016-01-01

    Parallel computing and steadily increasing computation speed have led to a new tool for analyzing multiple datasets and datatypes: fitting several datasets simultaneously. With this technique, physically connected parameters of individual data can be treated as a single parameter by implementing this connection into the fit directly. We discuss the terminology, implementation, and possible issues of simultaneous fits based on the X-ray data analysis tool Interactive Spectral Interpretation System (ISIS). While all data modeling tools in X-ray astronomy allow in principle fitting data from multiple data sets individually, the syntax used in these tools is not often well suited for this task. Applying simultaneous fits to the transient X-ray binary GRO J1008-57, we find that the spectral shape is only dependent on X-ray flux. We determine time independent parameters such as, e.g., the folding energy E_fold, with unprecedented precision.

  1. The Development of NASA's Fault Management Handbook

    Science.gov (United States)

    Dennehy, Neil

    2012-01-01

    NASA is developing a FM Handbook to establish guidelines and to provide recommendations for defining, developing, analyzing, evaluating, testing, and operating FM systems. It establishes a process for developing FM throughout the lifecycle of a mission and provides a basis for moving the field toward a formal and consistent FM methodology to be applied on future programs. This paper describes the motivation for, the development of, and the future plans for the NASA FM Handbook.

  2. Handbook of Markov chain Monte Carlo

    CERN Document Server

    Brooks, Steve

    2011-01-01

    ""Handbook of Markov Chain Monte Carlo"" brings together the major advances that have occurred in recent years while incorporating enough introductory material for new users of MCMC. Along with thorough coverage of the theoretical foundations and algorithmic and computational methodology, this comprehensive handbook includes substantial realistic case studies from a variety of disciplines. These case studies demonstrate the application of MCMC methods and serve as a series of templates for the construction, implementation, and choice of MCMC methodology.

  3. A Handbook of Essential Mathematical Formulae

    CERN Document Server

    Davies, Alan

    2005-01-01

    Intended for students of mathematics as well as of engineering, physical science, economics, business studies, and computer science, this handbook contains vital information and formulas for algebra, geometry, calculus, numerical methods, and statistics. Comprehensive tables of standard derivatives and integrals, together with the tables of Laplace, Fourier, and Z transforms are included. A spiral binding that allows the handbook to lay flat for easy reference enhances the user-friendly design.

  4. DOE fundamentals handbook: Mechanical science. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    The Mechanical Science Handbook was developed to assist nuclear facility operating contractors in providing operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of mechanical components and mechanical science. The handbook includes information diesel engines, heat exchangers, pumps, valves, and miscellaneous mechanical components. This information will provide personnel with a foundation for understanding the construction and operation of mechanical components that are associated with various DOE nuclear facility operations and maintenance.

  5. Handbook of Best Practices for Geothermal Drilling

    Energy Technology Data Exchange (ETDEWEB)

    Finger, John Travis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Blankenship, Douglas A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2012-02-01

    This Handbook is a description of the complex process that comprises drilling a geothermal well. The focus of the detailed Chapters covering various aspects of the process (casing design, cementing, logging and instrumentation, etc) is on techniques and hardware that have proven successful in geothermal reservoirs around the world. The Handbook will eventually be linked to the GIA web site, with the hope and expectation that it can be continually updated as new methods are demonstrated or proven.

  6. Maury Nussbaum reappointed as Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Maury Nussbaum, professor of industrial and systems engineering in the College of Engineering at Virginia Tech, has been reappointed as the Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering by the Virginia Tech Board of Visitors.

  7. Recent advances towards an International Year of Planet Earth——A letter to fellow geoscientist

    Institute of Scientific and Technical Information of China (English)

    F.J. de Mulder

    2006-01-01

    @@ Dear fellow geoscientist, I write to draw your attention to recent advances towards an International Year of Planet Earth, which is a joint initiative of the International Union of Geological Sciences (IUGS) and UNESCO.

  8. Frank Gwazdauskas honored with the American Dairy Science Association Fellow Award

    OpenAIRE

    Greiner, Lori A.

    2008-01-01

    Frank C. Gwazdauskas of Blacksburg, Va., the David and Margaret Lincicome Professor in the Department of Dairy Science in Virginia Tech's College of Agriculture and Life Sciences, received the 2008 American Dairy Science Association (ADSA) Fellow Award.

  9. Leo Piilonen appointed William E. Hassinger, Jr. Senior Faculty Fellow in Physics

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Leo Piilonen, professor of physics in the College of Science at Virginia Tech, was recently appointed the William E. Hassinger, Jr., Senior Faculty Fellow in Physics by the Virginia Tech Board of Visitors.

  10. Crisis Communication (Handbooks of Communication Science Vol. 23)

    DEFF Research Database (Denmark)

    Vol. 23 - The Handbook of Communication Science General editors: Peter J. Schultz and Paul Cobley......Vol. 23 - The Handbook of Communication Science General editors: Peter J. Schultz and Paul Cobley...

  11. Graduate Medical Education in Humanism and Professionalism: A Needs Assessment Survey of Pediatric Gastroenterology Fellows

    OpenAIRE

    Garvey, Katharine C.; Kesselheim, Jennifer C.; Herrick, Daniel B; WOOLF, Alan D.; Leichtner, Alan M.

    2014-01-01

    The deterioration of humanism and professionalism during graduate medical training is an acknowledged concern, and programs are required to provide professionalism education for pediatric fellows. We conducted a needs assessment survey in a national sample of 138 first- and second-year gastroenterology fellows (82% response rate). Most believed that present humanism and professionalism education met their needs, but this education was largely informal (eg, role modeling). Areas for formal edu...

  12. Clinical performance and skill retention after simulation-based education for nephrology fellows.

    Science.gov (United States)

    Ahya, Shubhada N; Barsuk, Jeffrey H; Cohen, Elaine R; Tuazon, Jennifer; McGaghie, William C; Wayne, Diane B

    2012-07-01

    We previously demonstrated that simulation-based education (SBE) improved temporary hemodialysis catheter (THDC) insertion skills by nephrology fellows. SBE, featuring deliberate practice and rigorous achievement standards, was a powerful method to enhance THDC insertion skills in nephrology fellows. However, experts have called for further research to evaluate skill transfer from the simulated environment to actual clinical care and skill retention. This is a prospective observational cohort study of THDC insertion skills. Twelve nephrology fellows from three academic centers in Chicago were evaluated using a skills checklist from July 2008 to June 2009. Simulator-trained fellows were tested after the SBE intervention and expected to meet or exceed a minimum passing score (MPS) set by an expert panel. To assess transfer of skill to clinical care, three simulator-trained fellows were assessed at 6 months on actual patient THDC insertions using the checklist. To assess retention of skill, 11 of 12 simulator-trained fellows were reassessed at 1 year using the checklist and central venous catheter simulator. Outcomes were determined by THDC insertion skill performance. Simulator-trained fellows scored similarly during 6-month THDC insertions on actual patients and immediate posttest (M = 86.2%, SD = 22.3% vs. M = 93.5%, SD = 5.3%, p = 0.32). However, 1 year after SBE, simulated THDC insertion scores were significantly lower than at immediate posttest (M = 73.4%, SD = 22.2% vs. M = 93.5%, SD = 5.3%, p = 0.01). Our results show that nephrology fellows who completed SBE displayed high levels of performance during THDC insertions on actual patients 6 months later. At 1 year, there was statistically significant skills decay. We recommend booster training at 6 months.

  13. Fuel Cell Handbook, Fifth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Energy and Environmental Solutions

    2000-10-31

    Progress continues in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in November 1998. Uppermost, polymer electrolyte fuel cells, molten carbonate fuel cells, and solid oxide fuel cells have been demonstrated at commercial size in power plants. The previously demonstrated phosphoric acid fuel cells have entered the marketplace with more than 220 power plants delivered. Highlighting this commercial entry, the phosphoric acid power plant fleet has demonstrated 95+% availability and several units have passed 40,000 hours of operation. One unit has operated over 49,000 hours. Early expectations of very low emissions and relatively high efficiencies have been met in power plants with each type of fuel cell. Fuel flexibility has been demonstrated using natural gas, propane, landfill gas, anaerobic digester gas, military logistic fuels, and coal gas, greatly expanding market opportunities. Transportation markets worldwide have shown remarkable interest in fuel cells; nearly every major vehicle manufacturer in the U.S., Europe, and the Far East is supporting development. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultrahigh efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 8 describe the six major fuel cell types and their performance based on cell operating conditions. Alkaline and intermediate solid state fuel cells were added to this edition of the Handbook. New information indicates that manufacturers have stayed

  14. Fuel Cycle System Analysis Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Steven J. Piet; Brent W. Dixon; Dirk Gombert; Edward A. Hoffman; Gretchen E. Matthern; Kent A. Williams

    2009-06-01

    This Handbook aims to improve understanding and communication regarding nuclear fuel cycle options. It is intended to assist DOE, Campaign Managers, and other presenters prepare presentations and reports. When looking for information, check here. The Handbook generally includes few details of how calculations were performed, which can be found by consulting references provided to the reader. The Handbook emphasizes results in the form of graphics and diagrams, with only enough text to explain the graphic, to ensure that the messages associated with the graphic is clear, and to explain key assumptions and methods that cause the graphed results. Some of the material is new and is not found in previous reports, for example: (1) Section 3 has system-level mass flow diagrams for 0-tier (once-through), 1-tier (UOX to CR=0.50 fast reactor), and 2-tier (UOX to MOX-Pu to CR=0.50 fast reactor) scenarios - at both static and dynamic equilibrium. (2) To help inform fast reactor transuranic (TRU) conversion ratio and uranium supply behavior, section 5 provides the sustainable fast reactor growth rate as a function of TRU conversion ratio. (3) To help clarify the difference in recycling Pu, NpPu, NpPuAm, and all-TRU, section 5 provides mass fraction, gamma, and neutron emission for those four cases for MOX, heterogeneous LWR IMF (assemblies mixing IMF and UOX pins), and a CR=0.50 fast reactor. There are data for the first 10 LWR recycle passes and equilibrium. (4) Section 6 provides information on the cycle length, planned and unplanned outages, and TRU enrichment as a function of fast reactor TRU conversion ratio, as well as the dilution of TRU feedstock by uranium in making fast reactor fuel. (The recovered uranium is considered to be more pure than recovered TRU.) The latter parameter impacts the required TRU impurity limits specified by the Fuels Campaign. (5) Section 7 provides flows for an 800-tonne UOX separation plant. (6) To complement 'tornado' economic

  15. Burnout, career satisfaction, and well-being among US neurology residents and fellows in 2016.

    Science.gov (United States)

    Levin, Kerry H; Shanafelt, Tait D; Keran, Christopher M; Busis, Neil A; Foster, Laura A; Molano, Jennifer Rose V; O'Donovan, Cormac A; Ratliff, Jeffrey B; Schwarz, Heidi B; Sloan, Jeff A; Cascino, Terrence L

    2017-08-01

    To study prevalence of and factors contributing to burnout, career satisfaction, and well-being in US neurology residents and fellows. A total of 938 US American Academy of Neurology member neurology residents and fellows were surveyed using standardized measures of burnout, career satisfaction, and well-being from January 19 to March 21, 2016. Response rate was 37.7% (354/938); about 2/3 of responders were residents and 1/3 were fellows. Median age of participants was 32 years and 51.1% were female. Seventy-three percent of residents and 55% of fellows had at least one symptom of burnout, the difference largely related to higher scores for depersonalization among residents. For residents, greater satisfaction with work-life balance, meaning in work, and older age were associated with lower risk of burnout; for fellows, greater satisfaction with work-life balance and effective support staff were associated with lower risk of burnout. Trainees experiencing burnout were less likely to report career satisfaction. Career satisfaction was more likely among those reporting meaning in work and more likely for those working in the Midwest compared with the Northeast region. Burnout is common in neurology residents and fellows. Lack of work-life balance and lack of meaning in work were associated with reduced career satisfaction and increased risk of burnout. These results should inform approaches to reduce burnout and promote career satisfaction and well-being in US neurology trainees. © 2017 American Academy of Neurology.

  16. Renal Ultrasound, Dialysis Catheter Placement, and Kidney Biopsy Experience of US Nephrology Fellows.

    Science.gov (United States)

    Sachdeva, Mala; Ross, Daniel W; Shah, Hitesh H

    2016-08-01

    Procedures are a key component to the practice of nephrology. The Accreditation Council for Graduate Medical Education (ACGME) requires nephrology fellows to acquire skills and demonstrate competency in the performance of several procedures during fellowship training, including temporary hemodialysis catheter placement, biopsy of native and transplanted kidneys, and various dialytic therapies. It is also required that fellows acquire competency in the interpretation of renal imaging, including renal ultrasound, during their training. To gain a more recent perspective of nephrology fellows' experiences regarding renal ultrasonography, dialysis catheter placement, and kidney biopsies, we carried out a national survey of nephrology fellows in May 2014. A majority of the programs did not offer formal clinical training in renal ultrasonography. In addition, a significant percentage of fellows in adult nephrology may not be acquiring the required procedural skills and competency during fellowship training. In this perspective, we explore some of the reasons for this occurrence and propose some measures that the nephrology training community can take to enhance procedural skills and competency of fellows. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  17. 9 CFR 390.3 - Indexes, reference guide, and handbook.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Indexes, reference guide, and handbook... INFORMATION § 390.3 Indexes, reference guide, and handbook. (a) Pursuant to the regulations in 7 CFR 1.4(c... description of major information and record locator systems. (c) FSIS will prepare a handbook for obtaining...

  18. 41 CFR 114-51.100 - Departmental Quarters Handbook.

    Science.gov (United States)

    2010-07-01

    ... Handbook. 114-51.100 Section 114-51.100 Public Contracts and Property Management Federal Property...-General § 114-51.100 Departmental Quarters Handbook. The Office of Acquisition and Property Management (PAM) has prepared the Departmental Quarters Handbook (DQH), 400 DM, which provides detailed guidelines...

  19. 75 FR 5317 - Exposure Factors Handbook: 2009 Update

    Science.gov (United States)

    2010-02-02

    ... AGENCY Exposure Factors Handbook: 2009 Update AGENCY: Environmental Protection Agency (EPA). ACTION... draft document titled, ``Exposure Factors Handbook 2009 Update'' (EPA/600/R- 09/052A). EPA previously... Environmental Assessment (NCEA) within EPA's Office of Research and Development. The Exposure Factors Handbook...

  20. Rationale for Student Dress Codes: A Review of School Handbooks

    Science.gov (United States)

    Freeburg, Elizabeth W.; Workman, Jane E.; Lentz-Hees, Elizabeth S.

    2004-01-01

    Through dress codes, schools establish rules governing student appearance. This study examined stated rationales for dress and appearance codes in secondary school handbooks; 182 handbooks were received. Of 150 handbooks containing a rationale, 117 related dress and appearance regulations to students' right to a non-disruptive educational…

  1. Springer Handbook of Crystal Growth

    CERN Document Server

    Dhanaraj, Govindhan; Prasad, Vishwanath; Dudley, Michael

    2010-01-01

    Over the years, many successful attempts have been made to describe the art and science of crystal growth. Most modern advances in semiconductor and optical devices would not have been possible without the development of many elemental, binary, ternary, and other compound crystals of varying properties and large sizes. The objective of the Springer Handbook of Crystal Growth is to present state-of-the-art knowledge of both bulk and thin-film crystal growth. The goal is to make readers understand the basics of the commonly employed growth processes, materials produced, and defects generated. Almost 100 leading scientists, researchers, and engineers from 22 different countries from academia and industry have been selected to write chapters on the topics of their expertise. They have written 52 chapters on the fundamentals of bulk crystal growth from the melt, solution, and vapor, epitaxial growth, modeling of growth processes and defects, techniques of defect characterization as well as some contemporary specia...

  2. Planetary Geologic Mapping Handbook - 2009

    Science.gov (United States)

    Tanaka, K. L.; Skinner, J. A.; Hare, T. M.

    2009-01-01

    . Terrestrial geologic maps published by the USGS now are primarily digital products using geographic information system (GIS) software and file formats. GIS mapping tools permit easy spatial comparison, generation, importation, manipulation, and analysis of multiple raster image, gridded, and vector data sets. GIS software has also permitted the development of project-specific tools and the sharing of geospatial products among researchers. GIS approaches are now being used in planetary geologic mapping as well (e.g., Hare and others, 2009). Guidelines or handbooks on techniques in planetary geologic mapping have been developed periodically (e.g., Wilhelms, 1972, 1990; Tanaka and others, 1994). As records of the heritage of mapping methods and data, these remain extremely useful guides. However, many of the fundamental aspects of earlier mapping handbooks have evolved significantly, and a comprehensive review of currently accepted mapping methodologies is now warranted. As documented in this handbook, such a review incorporates additional guidelines developed in recent years for planetary geologic mapping by the NASA Planetary Geology and Geophysics (PGG) Program s Planetary Cartography and Geologic Mapping Working Group s (PCGMWG) Geologic Mapping Subcommittee (GEMS) on the selection and use of map bases as well as map preparation, review, publication, and distribution. In light of the current boom in planetary exploration and the ongoing rapid evolution of available data for planetary mapping, this handbook is especially timely.

  3. Handbook of power systems II

    Energy Technology Data Exchange (ETDEWEB)

    Rebennack, Steffen [Colorado School of Mines, Golden, CO (United States). Div. of Economics and Business; Pardalos, Panos M. [Florida Univ., Gainesville, FL (United States). Dept. of Industrial and Systems Engineering; Pereira, Mario V.F. [Centro Empresarial Rio Praia de Botafogo, Rio de Janeiro (Brazil); Iliadis, Niko A. (eds.) [EnerCoRD, Athens (Greece)

    2010-07-01

    Energy is one of the world's most challenging problems, and power systems are an important aspect of energy related issues. This handbook contains state-of-the-art contributions on power systems modeling and optimization. The book is separated into two volumes with six sections, which cover the most important areas of energy systems. The first volume covers the topics operations planning and expansion planning while the second volume focuses on transmission and distribution modeling, forecasting in energy, energy auctions and markets, as well as risk management. The contributions are authored by recognized specialists in their fields and consist in either state-of-the-art reviews or examinations of state-of-the-art developments. The articles are not purely theoretical, but instead also discuss specific applications in power systems. (orig.)

  4. Handbook of power systems I

    Energy Technology Data Exchange (ETDEWEB)

    Rebennack, Steffen [Colorado School of Mines, Golden, CO (United States). Div. of Economics and Business; Pardalos, Panos M. [Florida Univ., Gainesville, FL (United States). Dept. of Industrial and Systems Engineering; Pereira, Mario V.F. [Centro Empresarial Rio Praia de Botafogo, Rio de Janeiro, RJ (Brazil); Iliadis, Niko A. (eds.) [EnerCoRD, Athens (Greece)

    2010-07-01

    Energy is one of the world's most challenging problems, and power systems are an important aspect of energy related issues. This handbook contains state-of-the-art contributions on power systems modeling and optimization. The book is separated into two volumes with six sections, which cover the most important areas of energy systems. The first volume covers the topics operations planning and expansion planning while the second volume focuses on transmission and distribution modeling, forecasting in energy, energy auctions and markets, as well as risk management. The contributions are authored by recognized specialists in their fields and consist in either state-of-the-art reviews or examinations of state-of-the-art developments. The articles are not purely theoretical, but instead also discuss specific applications in power systems. (orig.)

  5. Handbook of Climate Change Mitigation

    CERN Document Server

    Seiner, John; Suzuki, Toshio; Lackner, Maximilian

    2012-01-01

    There is a mounting consensus that human behavior is changing the global climate and its consequence could be catastrophic. Reducing the 24 billion metric tons of carbon dioxide emissions from stationary and mobile sources is a gigantic task involving both technological challenges and monumental financial and societal costs. The pursuit of sustainable energy resources, environment, and economy has become a complex issue of global scale that affects the daily life of every citizen of the world. The present mitigation activities range from energy conservation, carbon-neutral energy conversions, carbon advanced combustion process that produce no greenhouse gases and that enable carbon capture and sequestion, to other advanced technologies. From its causes and impacts to its solutions, the issues surrounding climate change involve multidisciplinary science and technology. This handbook will provide a single source of this information. The book will be divided into the following sections: Scientific Evidence of Cl...

  6. NASA information resources management handbook

    Science.gov (United States)

    1992-01-01

    This National Aeronautics and Space Administration (NASA) Handbook (NHB) implements recent changes to Federal laws and regulations involving the acquisition, management, and use of Federal Information Processing (FIP) resources. This document defines NASA's Information Resources Management (IRM) practices and procedures and is applicable to all NASA personnel. The dynamic nature of the IRM environment requires that the controlling management practices and procedures for an Agency at the leading edge of technology, such as NASA, must be periodically updated to reflect the changes in this environment. This revision has been undertaken to accommodate changes in the technology and the impact of new laws and regulations dealing with IRM. The contents of this document will be subject to a complete review annually to determine its continued applicability to the acquisition, management, and use of FIP resources by NASA. Updates to this document will be accomplished by page changes. This revision cancels NHB 2410.1D, dated April 1985.

  7. Handbook on Windows and Energy

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe; Svendsen, Sv Aa Højgaard

    The handbook on windows and energy is a general description of windows with the main focus put on the energy performance. Common window products are described by commonly used nomenclature, description of frame and sash conctructions and description of commonly used glazing types.The energy...... transmission through windows is described in detail including radiation, convection and conduction as well as solar transmittance of window glazing. The most used terms related to characterization of window energy performance are defined and calculation methods according to international standards...... are described.A method for estimation of the net energy flow on a yearly basis and/or during the heating season is presented. The method is able to combine the influence of window orientation, window size and window shape, type of glazing, frame area relative to total window area and type of spacer in sealed...

  8. Handbook factory planning and design

    CERN Document Server

    Wiendahl, Hans-Peter; Nyhuis, Peter

    2015-01-01

    This handbook introduces a methodical approach and pragmatic concept for the planning and design of changeable factories that act in strategic alliances to supply the ever-changing needs of the global market. In the first part, the change drivers of manufacturing enterprises and the resulting new challenges are considered in detail with focus on an appropriate change potential. The second part concerns the design of the production facilities and systems on the factory levels work place, section, building and site under functional, organisational, architectural and strategic aspects keeping in mind the environmental, health and safety aspects including corporate social responsibility. The third part is dedicated to the planning and design method that is based on a synergetic interaction of process and space. The accompanying project management of the planning and construction phase and the facility management for the effective utilization of the built premises close the book. -        Concise overview o...

  9. Handbook of archaeoastronomy and ethnoastronomy

    CERN Document Server

    2015-01-01

    How human communities interpret what they perceive in the sky is vital in fulfilling humankind’s most basic need to comprehend the universe it inhabits, both from a modern scientific perspective and from countless other cultural standpoints, extending right back to early prehistory. Archaeoastronomy, which is concerned with cultural perceptions and understandings of astronomical phenomena, is a rich cross-disciplinary field. The central aim of “Handbook of Archaeoastronomy” is to provide a reliable source for theory, method, interpretation and best practices that will give a definitive picture of the state of the art research in this field for serious scholars regardless of the discipline(s) in which they are qualified. It will be equally suitable for those already contributing to the field and those interested in entering it. Also included are studies in ethnoastronomy, which is concerned with contemporary practices related to astronomy, particularly among modern indigenous societies. A major part of t...

  10. Handbook of Advanced Magnetic Materials

    CERN Document Server

    Liu, Yi; Shindo, Daisuke

    2006-01-01

    From high-capacity, inexpensive hard drives to mag-lev trains, recent achievements in magnetic materials research have made the dreams of a few decades ago reality. The objective of Handbook of Advanced Magnetic Materials is to provide a timely, comprehensive review of recent progress in magnetic materials research. This broad yet detailed reference consists of four volumes: 1.) Nanostructured advanced magnetic materials, 2.) Characterization and simulation of advanced magnetic materials, 3.) Processing of advanced magnetic materials, and 4.) Properties and applications of advanced magnetic materials The first volume documents and explains recent development of nanostructured magnetic materials, emphasizing size effects. The second volume provides a comprehensive review of both experimental methods and simulation techniques for the characterization of magnetic materials. The third volume comprehensively reviews recent developments in the processing and manufacturing of advanced magnetic materials. With the co...

  11. Fuel Cell Handbook, Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

    1998-11-01

    Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

  12. FCRD Transmutation Fuels Handbook 2015

    Energy Technology Data Exchange (ETDEWEB)

    Janney, Dawn Elizabeth [Idaho National Lab. (INL), Idaho Falls, ID (United States); Papesch, Cynthia Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    Transmutation of minor actinides such as Np, Am, and Cm in spent nuclear fuel is of international interest because of its potential for reducing the long-term health and safety hazards caused by the radioactivity of the spent fuel. One important approach to transmutation (currently being pursued by the DOE Fuel Cycle Research & Development Advanced Fuels Campaign) involves incorporating the minor actinides into U-Pu-Zr alloys, which can be used as fuel in fast reactors. It is, therefore, important to understand the properties of U-Pu-Zr alloys, both with and without minor actinide additions. In addition to requiring extensive safety precautions, alloys containing U and Pu are difficult to study for numerous reasons, including their complex phase transformations, characteristically sluggish phase-transformation kinetics, tendency to produce experimental results that vary depending on the histories of individual samples, and sensitivity to contaminants such as oxygen in concentrations below a hundred parts per million. Many of the experimental measurements were made before 1980, and the level of documentation for experimental methods and results varies widely. It is, therefore, not surprising that little is known with certainty about U-Pu-Zr alloys, and that general acceptance of results sometimes indicates that there is only a single measurement for a particular property. This handbook summarizes currently available information about U, Pu, Zr, and alloys of two or three of these elements. It contains information about phase diagrams and related information (including phases and phase transformations); heat capacity, entropy, and enthalpy; thermal expansion; and thermal conductivity and diffusivity. In addition to presenting information about materials properties, it attempts to provide information about how well the property is known and how much variation exists between measurements. Although the handbook includes some references to publications about modeling

  13. Creation and Assessment of a Bad News Delivery Simulation Curriculum for Pediatric Emergency Medicine Fellows.

    Science.gov (United States)

    Chumpitazi, Corrie E; Rees, Chris A; Chumpitazi, Bruno P; Hsu, Deborah C; Doughty, Cara B; Lorin, Martin I

    2016-05-01

    Background  Bad news in the context of health care has been broadly defined as significant information that negatively alters people's perceptions of the present or future. Effectively delivering bad news (DBN) in the setting of the emergency department requires excellent communication skills. Evidence shows that bad news is frequently given inadequately. Studies show that trainees need to devote more time to developing this skill through formalized training. This program's objectives were to utilize trained standardized patients in a simulation setting to assist pediatric emergency medicine (PEM) fellows in the development of effective, sensitive, and compassionate communication with patients and family members when conveying bad news, and to recognize and respond to the patient/parent's reaction to such news. Methods PEM fellows participated in a novel curriculum utilizing simulated patients (SPs) acting as the patient's parent and immersive techniques in a realistic and supportive environment. A baseline survey was conducted to ascertain participant demographics and previous experience with simulation and DBN. Experienced, multi-disciplinary faculty participated in a training workshop with the SPs one week prior to course delivery. Three scenarios were developed for bad news delivery. Instructors watched via remote video feed while the fellows individually interacted with the SPs and then participated in a confidential debriefing. Fellows later joined for group debriefing. Fellow characteristics, experience, and self-perceived comfort pre/post-course were collected.   Results Baseline data demonstrated that 78% of fellows reported DBN two or more times per month. Ninety-three percent of fellows in this study were present during the delivery of news about the death of a child to a parent or family member in the six-month period preceding this course. Fellows' self-reported comfort level in DBN to a patient/family and dealing with patient and parent emotions

  14. [Man and his fellow-creatures under ethical aspects

    Science.gov (United States)

    Teutsch

    1999-01-01

    to animals presented in such completeness and thoroughness, together with the distance and objectivity originating in the legal stance. The book is of invaluable significance in particular for the commentators of the German animal protection law as amended in 1998: For the first time, they are now in a position to draw from an abundance of facts and evaluations relevant to animal protection. It appears as a fortunate circumstance in this context, that not only the traditional Lorz-commentary is being continued (Albert Lorz and Ernst Metzger: "Tierschutzgesetz" [Animal Protection Law], commentary, 5th edition) but also a completely new commentary is being developed by the team of Hans Georg Kluge, ed., Antoine F. Goetschel, Jörg Hartung, Eisenhart von Loeper, Jost Dietrich Ort and Kerstin Reckwell: "Kommentar zum Tierschutzgesetz" (Commentary to the Animal Protection Law). "Moral Status" is not only the title of an important investigation by Mary Anne Warren (in the introductory chapter she describes and evaluates the basics of the Status-discussion to date) but also a topic singularly dominating the scientific discourse. Out of rejection or reservation regarding the biocentrical position of Albert Schweitzer or Paul W. Taylor, time after time new restricting concepts have been introduced. In the same way, the criterion of the ability to suffer as developed by Bentham was considered by some as too far reaching. In considering animals ethically the line can be drawn so tightly that, aside from apes and maybe some large marine mammals, the whole of the animal kingdom can be degraded to at best, the ecological worthy resources of man; and all this without being suspected of an adversary position to animal protection. At times, the impression arises that science is seeking and finding ever new hurdles in order to keep the number of morally considered fellow-creatures as small as possible. Following common opinion, even animals with moral status are only entitled to

  15. Assessment of Abilities of Gastroenterology Fellows to Provide Information to Patients With Liver Disease.

    Science.gov (United States)

    Chaudhary, Noami; Lucero, Catherine; Villanueva, Gerald; Poles, Michael; Gillespie, Colleen; Zabar, Sondra; Weinshel, Elizabeth

    2017-07-01

    Patient education is critical in ensuring patient compliance and good health outcomes. Fellows must be able to effectively communicate with their patients, delivering enough information for the patient to understand their medical problem and maximize patient compliance. We created an objective structured clinical examination (OSCE) with 4 liver disease cases to assess fellows' knowledge and ability to inform standardized patients (SPs) about their clinical condition. We developed 4 cases highlighting different aspects of liver disease and created a 4-station OSCE: hepatitis B, acute hepatitis C, new diagnosis of cirrhosis, and an end-stage cirrhotic nontransplant candidate. The SP with hepatitis B was minimizing the fact that she could not read English. The acute hepatitis C SP was a nursing student who is afraid that having hepatitis C might jeopardize her career. The SP with the new diagnosis of alcoholic cirrhosis needed to stop drinking, and the end-stage liver disease patient had to grapple with his advanced directives. Twelve fellows from 4 GI training programs participated. Our focus was to assess the fellows' knowledge about liver diseases and the Accreditation Council for Graduate Medical Education competencies of health literacy, shared decision making, advanced directives, and goals of care. The goal for the fellows was to communicate effectively with the SPs, and acknowledge that each patient had an emotionally charged issue to overcome. The SPs used a checklist to rate fellows' performance. Faculty and the SPs observed the cases and provided feedback. The fellows were surveyed on their performance regarding the case. The majority of fellows were able to successfully summarize findings and discuss a plan with the patient in the new diagnosis of cirrhosis (76.92%) and hepatitis C case (100%), but were less successful in the hepatitis B case (30.77%) and the end-of-life case (41.67%). Overall, a small percentage of fellows reflected that they did a good

  16. Abstracts of the 28. annual meeting of the Austrian Radiation Oncology, Radiation Biology and Medical Radiation Physics Society (OeGRO 2011); Abstracts der 28. Jahrestagung der Oesterreichischen Gesellschaft fuer Radioonkologie, Radiobiologie und Medizinische Radiophysik (OeGRO 2011)

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2012-06-15

    The second part of the volume includes the abstracts of the 28th annual meeting of the Austrian Radiation Oncology, Radiation Biology and Medical Radiation Physics Society (OeGRO 2011), covering the following topics: extracranial stereotactic radiotherapy; brachytherapy, hyperthermia; radiotherapy side effects; psycho-oncology in radiotherapy; head-neck carcinomas; radiation source implants for carcinoma irradiation; MRI-supported adaptive radiotherapy; CT-guided radiotherapy; mammary carcinomas; prostate carcinomas; magnetic nanoparticles for future medical applications.

  17. Teaching geriatric fellows how to teach: a needs assessment targeting geriatrics fellowship program directors.

    Science.gov (United States)

    Rivera, Veronica; Yukawa, Michi; Aronson, Louise; Widera, Eric

    2014-12-01

    The entire healthcare workforce needs to be educated to better care for older adults. The purpose of this study was to determine whether fellows are being trained to teach, to assess the attitudes of fellowship directors toward training fellows to be teachers, and to understand how to facilitate this type of training for fellows. A nine-question survey adapted from a 2001 survey issued to residency program directors inquiring about residents-as-teachers curricula was developed and administered. The survey was issued electronically and sent out three times over a 6-week period. Of 144 ACGME-accredited geriatric fellowship directors from geriatric, internal medicine, and family medicine departments who were e-mailed the survey, 101 (70%) responded; 75% had an academic affiliation, 15% had a community affiliation, and 10% did not report. Academic and community programs required their fellows to teach, but just 55% of academic and 29% of community programs offered teaching skills instruction as part of their fellowship curriculum; 67% of academic programs and 79% of community programs felt that their fellows would benefit from more teaching skill instruction. Program directors listed fellow (39%) and faculty (46%) time constraints as obstacles to creation and implementation of a teaching curriculum. The majority of fellowship directors believe that it is important for geriatric fellows to become competent educators, but only approximately half of programs currently provide formal instruction in teaching skills. A reproducible, accessible curriculum on teaching to teach that includes a rigorous evaluation component should be created for geriatrics fellowship programs. © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

  18. Use and usefulness of laboratory handbooks.

    Science.gov (United States)

    Stakkestad, J A; Sandberg, S; Bjerve, K S; Runde, I; Asberg, A

    1997-11-01

    The aim of this study was to investigate how reference handbooks distributed by hospital laboratories are used by medical doctors, and to what extent this kind of information can influence or change doctors' work habits. We also wanted to see if books with various contents of information are valued differently by the users, and we asked for preferences for an ideal book. A questionnaire was sent to 2075 medical doctors served by five Norwegian hospital laboratories. The overall response rate was 66%, of whom 76% had received a handbook. Seventy-eight percent of respondents who stated that they had received a handbook kept it in their consulting room and 45% used it once or more weekly. The majority (89%) found the books beneficial in their everyday work. Many doctors (36%) claimed that they had changed their routines as a result of the information in the book. The way of interpreting test results was influenced most often, followed by indications for ordering laboratory tests, sample collection and specimen handling, and patient preparation. Nearly all respondents (97%) felt that handbooks of this kind are beneficial to their technical and nursing staff. The results show that handbooks distributed by medical laboratories are well received, frequently used and highly appreciated by medical doctors. Comprehensive books are rated higher than smaller books.

  19. The Fuel Handbook 2012; Braenslehandboken 2012

    Energy Technology Data Exchange (ETDEWEB)

    Stroemberg, Birgitta; Herstad Svaerd, Solvie

    2012-04-15

    This fuel handbook provides, from a plant owner's perspective, a method of evaluating different fuels on the market. The fuel handbook concerns renewable fuels (but not including household waste) that are available on the Swedish market today or which are judged to have the potential to be available within the next ten years. The handbook covers 31 different fuels. Analysis data, special properties, operating experience, recommendations, risks when using the fuels and literature references are outlined for each fuel. The handbook also contains 1. A proposed route to follow when one plans to introduce a new fuel. Those analyses and tests one should perform to reduce the risk of encountering problems. 2. A summary of relevant laws and taxes for energy production, with directions as to where relevant documentation can be found. 3. Theory and background to judge the fuel's combustion, ash and corrosion properties and different methods that can be used for such judgement. 4. Summary of standards, databases and handbooks for biomass fuels and other solid fuels, and details on where further information on the fuels can be found, with the help of links to different web sites. Included in the annexes are 1. A proposal for a standard procedure for test burning of fuel. 2. Calculations procedures for, amongst others, heating value, flue gas composition and key numbers. In addition, calculations routines for different units for a number of different applications are provided

  20. The lesional skin of linear IgA bullous dermatosis expresses growth-regulated peptide (GRO)-alpha.

    Science.gov (United States)

    Tsunemi, Yuichiro; Ihn, Hironobu; Saeki, Hidehisa; Tamaki, Kunihiko

    2004-07-01

    The patient was a 62-year-old man with erythema with tense vesiculobullae and erosions on the bilateral elbows, right knee, and one buttock. A skin biopsy specimen revealed subepidermal blister formation with a predominant infiltration of neutrophils and papillary neutrophilic microabscesses. Direct immunofluorescence study showed linear deposition of IgA and weak deposition of IgG at the basement membrane zone of the lesional skin, and indirect immunofluorescence study showed linear deposition of IgA at the epidermal side of the 1M NaCl-separated normal skin. He was diagnosed with linear IgA bullous dermatosis. Immunohistochemical study revealed that the lesional and perilesional keratinocytes expressed growth-regulated peptide (GRO) -alpha, a potent chemoattractant for neutrophils. This suggests that GRO-alpha plays a role in the infiltration of neutrophils into the lesional skin and in bulla formation in linear IgA bullous dermatosis.