WorldWideScience

Sample records for grism response curves

  1. Revised Wavelength and Spectral Response Calibrations for AKARI Near-Infrared Grism Spectroscopy: Cryogenic Phase

    CERN Document Server

    Baba, S; Shirahata, M; Isobe, N; Usui, F; Ohyama, Y; Onaka, T; Yano, K; Kochi, C

    2016-01-01

    We perform revised spectral calibrations for the AKARI near-infrared grism to quantitatively correct for the effect of the wavelength-dependent refractive index. The near-infrared grism covering the wavelength range of 2.5--5.0 micron with a spectral resolving power of 120 at 3.6 micron, is found to be contaminated by second-order light at wavelengths longer than 4.9 micron which is especially serious for red objects. First, we present the wavelength calibration considering the refractive index of the grism as a function of the wavelength for the first time. We find that the previous solution is positively shifted by up to 0.01 micron compared with the revised wavelengths at 2.5--5.0 micron. In addition, we demonstrate that second-order contamination occurs even with a perfect order-sorting filter owing to the wavelength dependence of the refractive index. Second, the spectral responses of the system from the first- and second-order light are simultaneously obtained from two types of standard objects with dif...

  2. Grisms Developed for FOCAS

    CERN Document Server

    Ebizuka, Noboru; Oka, Keiko; Yamada, Akiko; Kashiwagi, Masako; Kodate, Kashiko; Hattori, Takashi; Kashikawa, Nobunari; Iye, Masanori

    2011-01-01

    Faint Object Camera and Spectrograph (FOCAS) is a versatile common-use optical instrument for the 8.2m Subaru Telescope, offering imaging and spectroscopic observations. FOCAS employs grisms with resolving powers ranging from 280 to 8200 as dispersive optical elements. A grism is a direct-vision grating composed of a transmission grating and prism(s). FOCAS has five grisms with replica surface-relief gratings including an echelle-type grism, and eight grisms with volume-phase holographic (VPH) gratings. The size of these grisms is 110 mm X 106 mm in aperture with a maximum thickness of 110 mm. We employ not only the dichromated gelatin, but also the hologram resin as a recording material for VPH gratings. We discuss the performance of these FOCAS grisms measured in the laboratory, and verify it by test observations, and show examples of astronomical spectroscopic observations.

  3. Compact Grism Spectrometer

    Science.gov (United States)

    Teare, S. W.

    2003-05-01

    Many observatories and instrument builders are retrofitting visible and near-infrared spectrometers into their existing imaging cameras. Camera designs that reimage the focal plane and have the optical filters located in a pseudo collimated beam are ideal candidates for the addition of a spectrometer. One device commonly used as the dispersing element for such spectrometers is a grism. The traditional grism is constructed from a prism that has had a diffraction grating applied on one surface. The objective of such a design is to use the prism wedge angle to select the desired "in-line" or "zero-deviation" wavelength that passes through on axis. The grating on the surface of the prism provides much of the dispersion for the spectrometer. A grism can also be used in a "constant-dispersion" design which provides an almost linear spatial scale across the spectrum. In this paper we provide an overview of the development of a grism spectrometer for use in a near infrared camera and demonstrate that a compact grism spectrometer can be developed on a very modest budget that can be afforded at almost any facility. The grism design was prototyped using visible light and then a final device was constructed which provides partial coverage in the near infrared I, J, H and K astronomical bands using the appropriate band pass filter for order sorting. The near infrared grism presented here provides a spectral resolution of about 650 and velocity resolution of about 450 km/s. The design of this grism relied on a computer code called Xspect, developed by the author, to determine the various critical parameters of the grism. This work was supported by a small equipment grant from NASA and administered by the AAS.

  4. Description of dose response curve

    OpenAIRE

    Al-Samarai, Firas

    2011-01-01

    The book included several methods to estimate LD50, in addition to explain how to use several programs to estimate LD50. Moreover the book illustrate the description of the dose response curves. Firas Al-Samarai

  5. Final design and choices for EUCLID NISP grism

    Science.gov (United States)

    Costille, A.; Caillat, A.; Rossin, C.; Pascal, S.; Sanchez, P.; Foulon, B.; Vives, S.

    2016-07-01

    ESA Euclid mission is designed to map the geometry of the dark Universe. The NISP (Near Infrared Spectro- Photometer) is one of its two instruments dedicated to NIR with two main observing modes: the photometric mode and the spectroscopic mode, for the acquisition of slitless dispersed images using four low resolution grisms: three "red" grisms for 1250-1850nm, and one "blue" grism for 920-1300nm. The NISP grisms are complex optical components that combine four main functions: a grism done by the grating on the prism hypotenuse, a spectral filter done by a multilayer filter deposited on the first surface of the prism, a focus function done by a curved surface and a spectral wavefront correction done by the grating with curved grooves. This specific grating is made thanks to a new technic developed with SILIOS Technologies to manufacture a resin-free grating. The optical component is glued onto a mechanical ring, designed to survive to 60g DLL and to keep optical performance at 130K. The design and manufacturing of these components represent an important challenge to obtain the best performances with very constraining requirements. We will present the performance obtained on scale-1 prototypes of the filter, the grating and the mount manufactured to validate the final design choices and used to make the necessary trade-off during the development phase. All the prototypes have shown very good optical performances and have withstood vibrations and vacuum cryogenic tests that confirm the feasibility of NISP grisms and prepare the next phase for the procurement and tests of NISP grism flight models.

  6. A Low Cost Grism Spectrometer for Small Telescopes

    Science.gov (United States)

    Ludovici, Dominic

    2016-06-01

    We have designed and built a low cost (appx. $500) low resolution (R ~ 300) grating-prism (grism) spectrometer for the University of Iowa's robotic observatory. Grism spectrometers differ from simple transmission grating systems by partially compensating for the curved focal plane using a wedge prism. The spectrometer has five optical elements, and was designed using a ray tracing program. The collimating and focusing optics are easily modified for other telescope optics. The optics are mounted in an enclosure made with a 3-d printer. The spectrometer was installed in a modified (extended) filter wheel and has been in routine operation since January 2016. I will show sample spectra using this system and discuss spectral calibration, and optical design considerations for other telescopes. I will also discuss how low-resolution spectrometers can be used in undergraduate teaching laboratories.

  7. Inferring mechanisms from dose-response curves

    OpenAIRE

    Chow, Carson C.; Ong, Karen M.; Dougherty, Edward J.; Simons, S. Stoney

    2011-01-01

    The steady state dose-response curve of ligand-mediated gene induction usually appears to precisely follow a first-order Hill equation (Hill coefficient equal to 1). Additionally, various cofactors/reagents can affect both the potency and the maximum activity of gene induction in a gene-specific manner. Recently, we have developed a general theory for which an unspecified sequence of steps or reactions yields a first-order Hill dose-response curve (FHDC) for plots of the final product vs. ini...

  8. Task 4 Improvised Nuclear Device Response Curves

    Energy Technology Data Exchange (ETDEWEB)

    Alai, Maureen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Neuscamman, Stephanie [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-05-31

    LLNL performed fallout and nuclear blast modeling for the 60 cities using the NARAC modeling system and predominant weather patterns determined in a previous Task 4 effort. LLNL performed model simulations and analyses to identify and provide response curves (expressed as two-dimensional contours) for radioactive fallout deposition, transport, population, and blast overpressure as a function of yield, weather, location and time. These contours can then be further combined and correlated with infrastructure and population databases to estimate city specific effects on KPFs such as impacted infrastructure and casualty rates.

  9. The Swift UVOT grism calibration and example spectra

    CERN Document Server

    Kuin, Paul; Page, Mat

    2015-01-01

    The calibration of the two UVOT grisms which provide slitless spectroscopy in the 170-500 nm (UV grism) and 295-660 nm (visible grism) ranges has been completed. The UV grism has a spectral resolution ($\\lambda/\\Delta\\lambda$) of 75 at $\\lambda$2600 \\AA\\ for source magnitudes of u=10-16 mag, while the visible grism has a spectral resolution of 100 at $\\lambda$4000 \\AA\\ for source magnitudes of b=12-17 mag. For brighter spectra, coincidence loss (pile-up) occurs in the photon-counting detector. A correction for the coincidence loss in grism spectra has been developed, and limits have been established above which that correction fails. After discussing the UVOT grisms and their calibration, an illustration is given of the breadth of the UVOT grism spectroscopy.

  10. A more generalized coordinate transformation approach for grisms

    Science.gov (United States)

    Pirzkal, Norbert; Ryan, Russell

    2017-01-01

    Current HST configuration files for the NICMOS, ACS and WFC3 grisms have been based on the aXe configuration file methodology. These files describe how spectra are physically dispersed for individual orders when using a particular detector and instrument. With the addition of direct filter wedge offsets in the grism calibration of the WFC3 G102 and G141 grisms and with new instruments on the horizon, such as JWST NIRCAM, the current aXe method to describe the grism dispersion needs to be generalized. Here we introduce an updated version of the grism dispersion parametrization.

  11. The Swift-UVOT ultraviolet and visible grism calibration

    CERN Document Server

    Kuin, N P M; Breeveld, A A; Page, M J; James, C; Lamoureux, H; Mehdipour, M; Still, M; Yershov, V; Brown, P J; Carter, M; Mason, K O; Kennedy, T; Marshall, F; Roming, P W A; Siegel, M; Oates, S; Smith, P J; De Pasquale, M

    2015-01-01

    We present the calibration of the Swift UVOT grisms, of which there are two, providing low-resolution field spectroscopy in the ultraviolet and optical bands respectively. The UV grism covers the range 1700-5000 Angstrom with a spectral resolution of 75 at 2600 Angstrom for source magnitudes of u=10-16 mag, while the visible grism covers the range 2850-6600 Angstrom with a spectral resolution of 100 at 4000 Angstrom for source magnitudes of b=12-17 mag. This calibration extends over all detector positions, for all modes used during operations. The wavelength accuracy (1-sigma) is 9 Angstrom in the UV grism clocked mode, 17 Angstrom in the UV grism nominal mode and 22 Angstrom in the visible grism. The range below 2740 Angstrom in the UV grism and 5200 Angstrom in the visible grism never suffers from overlapping by higher spectral orders. The flux calibration of the grisms includes a correction we developed for coincidence loss in the detector. The error in the coincidence loss correction is less than 20%. The...

  12. A Grism Design Review and the as-built performance of the silicon grisms for JWST-NIRCAM

    CERN Document Server

    Deen, Casey; Wang, Weisong; Pozderac, Jasmina; Mar, Douglas; Jaffe, Daniel

    2016-01-01

    Grisms are dispersive transmission optics that find their most frequent use in instruments that combine imaging and spectroscopy. This application is particularly popular in the infrared where imagers frequently have a cold pupil in their optical path that is a suitable location for a dispersive element. In particular, several recent and planned space experiments make use of grisms in slit-less spectrographs capable of multi-object spectroscopy. We present an astronomer-oriented general purpose introduction to grisms and their use in current and future astronomical instruments. We present a simple, step-by-step procedure for adding a grism spectroscopy capability to an existing imager design. This procedure serves as an introduction to a discussion of the device performance requirements for grisms, focusing in particular on the problems of lithographically patterned silicon devices, the most effective grism technology for the 1.1-8 micron range. We begin by summarizing the manufacturing process of monolithic ...

  13. Review of dose-response curves for acute antimigraine drugs

    DEFF Research Database (Denmark)

    Hougaard, Anders; Tfelt-Hansen, Peer

    2015-01-01

    INTRODUCTION: Dose-response curves for efficacy and tolerability are the important determinants for the choice of doses of acute migraine drugs. Areas covered: Dose-response curves for the efficacy of seven triptans (5-HT1B/1D receptor agonists), a 5-HT1F receptor agonist (lasmiditan) and four oral...... calcitonin-gene related peptide receptor antagonists (telcagepant, MK-3207, BI 44370 TA and BMS-927711) in placebo-controlled trials were reviewed. In addition, dose-response curves for adverse events (AEs) were reviewed. Expert opinion: For most triptans, the dose-response curve for efficacy is flat......, whereas AEs often increase with increasing doses. The two other groups of drugs also have flat dose-response curves for efficacy. Overall, the triptans still have the most favorable efficacy-tolerability profile. Current acute antimigraine drugs do not fulfill the expectations of the patients, and thus...

  14. Cryogenic Volume-Phase Holograpic Grisms for MOIRCS

    CERN Document Server

    Ebizuka, Noboru; Yamada, Toru; Tokoku, Chihiro; Onodera, Masato; Hanesaka, Mai; Kodate, Kashiko; Uchimoto, Yuka Katsuno; Maruyama, Miyoko; Shimasaku, Kazuhiro; Tanaka, Ichi; Yoshikawa, Tomohiro; Kashikawa, Nobunari; Iye, Masanori; Ichikawa, Takashi

    2011-01-01

    We have developed high dispersion VPH (volume phase holographic) grisms with zinc selenide (ZnSe) prisms for the cryogenic optical system of MOIRCS (Multi-Object near InfraRed Camera and Spectrograph) for Y-, J-, H- and K- band observations. We fabricated the VPH gratings using a hologram resin. After several heat cycles at between room temperature and 120 K, the VPH gratings were assembled to grisms by gluing with two ZnSe prisms. Several heat cycles were also carried out for the grisms before being installed into MOIRCS. We measured the efficiencies of the VPH grisms in a laboratory, and found them to be 70% - 82%. The performances obtained by observations of MOIRCS with the 8.2 m Subaru Telescope have been found to be very consistent with the results in the laboratory test. This is the first astronomical application of cryogenic VPH grisms.

  15. Nonparallel nephrotoxicity dose-response curves of aminoglycosides.

    OpenAIRE

    1981-01-01

    Nephrotoxicity comparisons of aminoglycosides in rats, utilizing large multiples of human doses, have indicated an advantage for netilmicin. However, no nephrotoxicity advantage of netilmicin has been demonstrated at the lower doses used in clinics. Some high-dose studies in rats have also suggested that the slope of the nephrotoxicity dose-response curve of netilmicin was less steep than the slopes of other aminoglycosides. Therefore, the slopes of the nephrotoxicity dose-response curves of ...

  16. The Hubble Legacy Archive ACS Grism Data

    CERN Document Server

    Kuemmel, M; Fosbury, R; Haase, J; Hook, R N; Kuntschner, H; Lombardi, M; Micol, A; Nilsson, K K; Stoehr, F; Walsh, J R

    2011-01-01

    A public release of slitless spectra, obtained with ACS/WFC and the G800L grism, is presented. Spectra were automatically extracted in a uniform way from 153 archival fields (or "associations") distributed across the two Galactic caps, covering all observations to 2008. The ACS G800L grism provides a wavelength range of 0.55-1.00 \\mu$m, with a dispersion of $40 \\ \\AA / pixel$ and a resolution of $\\sim 80\\ \\AA$ for point-like sources. The ACS G800L images and matched direct images were reduced with an automatic pipeline that handles all steps from archive retrieval, alignment and astrometric calibration, direct image combination, catalogue generation, spectral extraction and collection of metadata. The large number of extracted spectra (73,581) demanded automatic methods for quality control and an automated classification algorithm was trained on the visual inspection of several thousand spectra. The final sample of quality controlled spectra includes 47,919 datasets (65% of the total number of extracted spect...

  17. Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine.

    OpenAIRE

    Cockcroft, D. W.; Berscheid, B A

    1983-01-01

    The value of determining the slope of the histamine dose-response curve, in addition to the histamine provocation concentration producing a 20% reduction in FEV1 (PC20-FEV1), was assessed by analysis of histamine dose-response curves in 40 patients selected as having a wide range of increased non-specific bronchial responsiveness to inhaled histamine. The histamine dose-response curves were found to be fit the linear curve (dose v response, mean r2 = 0.97) better than the logarithmic curve (l...

  18. First results from Faint Infrared Grism Survey (FIGS)

    DEFF Research Database (Denmark)

    Tilvi, V.; Pirzkal, N.; Malhotra, S.

    2016-01-01

    in the Faint Infrared Grism Survey (FIGS). These spectra, taken with G102 grism on Hubble Space Telescope (HST), show a significant emission line detection (6{\\sigma}) in multiple observational position angles (PA), with total integrated Ly{\\alpha} line flux of 1.06+/- 0.12 e10-17erg s-1cm-2. The line flux......-redshift AGN yet found. Thus, this observation from the Hubble Space Telescope clearly demonstrates the sensitivity of the FIGS survey, and the capability of grism spectroscopy to study the epoch of reionization....

  19. GLASS: The Grism Lens-Amplified Survey From Space. HST Grism Spectroscopy of the Frontier Fields

    Science.gov (United States)

    Schmidt, Kasper B.; Schmidt

    The Grism Lens-Amplified Survey From Space (GLASS) is a 140 orbit spectroscopic survey of 10 massive galaxy clusters, including the six Hubble Frontier Fields. GLASS has observed the cluster cores with the HST-WFC3 G102 and G141 grisms providing a wide wavelength coverage in the near-infrared from roughly 0.8-1.7μm. The parallel fields were observed through the optical ACS G800L grism. Taking advantage of the lensing magnification of the clusters, GLASS reaches intrinsic spectroscopic 1σ flux limits of roughly 10-18erg/s/cm2 and improved spatial resolution for lensed sources behind the clusters. These features are particularly useful for the three main science drivers of GLASS which are, I) exploring the universe at the epoch of reionization, II) describe how metals cycle in and out of galaxies, and III) asses the environmental dependence of galaxy evolution. The former two benefit highly from the improved depth and increased resolution provided by the cluster lensing. Apart from the main science drivers, a slew of ancillary science has been enabled by the survey, including improving cluster lens modeling and searches for supernovae. Here we present the survey and the GLASS data releases, which are continuously being made available to the community through https://archive.stsci.edu/prepds/glass/. For further information we refer to Schmidt et al. (2014), Treu et al. (2015), and http://glass.physics.ucsb.edu.

  20. GRISM Spectophotometry of the Uranus Ring

    Science.gov (United States)

    Smith, Bradford

    1997-07-01

    Details of the near-infrared spectral reflectance of the Uranus rings are poorly known, because of problems associated with the scattered light from the planet. Grism spectroscopy of the brightest part of the Epsilon ring will be made with the planet just outside the field of view. To minimize the glare from Uranus, the observations should made when the widest part of the Epsilon ring is at a position angle of approximately 174 degrees. This is one in a series of observations designed to intercompare the near-infrared spectral reflectivity of dark objects in the solar system. Some record of processes that occurred within the Uranus subnebula may be left on the surfaces of the ring particles or the surface coatings of the associated dark inner satellites.

  1. Dose-response curve estimation: a semiparametric mixture approach.

    Science.gov (United States)

    Yuan, Ying; Yin, Guosheng

    2011-12-01

    In the estimation of a dose-response curve, parametric models are straightforward and efficient but subject to model misspecifications; nonparametric methods are robust but less efficient. As a compromise, we propose a semiparametric approach that combines the advantages of parametric and nonparametric curve estimates. In a mixture form, our estimator takes a weighted average of the parametric and nonparametric curve estimates, in which a higher weight is assigned to the estimate with a better model fit. When the parametric model assumption holds, the semiparametric curve estimate converges to the parametric estimate and thus achieves high efficiency; when the parametric model is misspecified, the semiparametric estimate converges to the nonparametric estimate and remains consistent. We also consider an adaptive weighting scheme to allow the weight to vary according to the local fit of the models. We conduct extensive simulation studies to investigate the performance of the proposed methods and illustrate them with two real examples.

  2. Inner detached frequency response curves: an experimental study

    Science.gov (United States)

    Gatti, Gianluca; Brennan, Michael J.

    2017-05-01

    Certain nonlinear vibrating systems have frequency response curves (FRCs), in which isolated detached curves exist inside the main continuous FRC. The behavior of these systems has hitherto been studied analytically and numerically, but to the authors' knowledge, there is no record of an inner detached FRC being detected experimentally. These curves may be hidden by numerical or experimental analysis, particularly when a system is subject to swept or stepped-sine excitation. Their existence may thus lead to unexpected dramatic changes in the amplitude of the system response. This paper presents an experimental study that involves the design, construction and testing of a specific system that has an isolated detached FRC inside the main continuous FRC. The experimental design of the test rig is supported by multibody dynamic simulations, and in the experimental tests the existence of a detached FRC was verified.

  3. A universal dose–response curve for radiochromic films

    Energy Technology Data Exchange (ETDEWEB)

    Martín-Viera Cueto, J. A., E-mail: josea.martinviera.sspa@juntadeandalucia.es; Parra Osorio, V.; Moreno Sáiz, C.; Navarro Guirado, F.; Casado Villalón, F. J.; Galán Montenegro, P. [Radiofísica Hospitalaria, Hospital Regional Universitario, Málaga 29010 (Spain)

    2015-01-15

    Purpose: This paper presents a model for dose–response curves of radiochromic films. It is based on a modified version of single-hit model to take into account the growth experienced by lithium salt of pentacosa-10,12-diynoic acid polymers after irradiation. Methods: Polymer growth in radiochromic films is a critical phenomenon that can be properly described by means of percolation theory to provide an appropriate distribution function for polymer sizes. Resulting functional form is a power function featuring a critical exponent and two adjustable parameters. Moreover, these parameters act as scaling factors setting a natural scale for sensitometric curves where the dependence on channel sensitivity is removed. A unique reduced response curve is then obtained from all the color channels describing film behavior independently of film dosimetry system. Results: Resulting functional form has been successfully tested in several sensitometric curves from different Gafchromic EBT models, providing excellent agreement with experimental data in a wide dose range up to about 40 Gy and low dose uncertainty. Conclusions: The model presented in this paper describes accurately the sensitometric curves of radiochromic films in wide dose ranges covering all typical ranges used in external radiotherapy. Resulting dose uncertainty is low enough to render a reasonably good performance in clinical applications. Due to cross-correlation, only one of the adjustable parameters is totally independent and characterizes film batches.

  4. GLASS: The Grism Lens-Amplified Survey From Space. HST Grism Spectroscopy of the Frontier Fields.

    Science.gov (United States)

    Borello Schmidt, Kasper

    2015-08-01

    The Grism Lens-Amplified Survey From Space (GLASS) is a 140 orbit spectroscopic survey of 10 massive galaxy clusters, including the six Hubble Frontier Fields. GLASS has observed the cluster cores in the HST-WFC3 G102 and G141 grisms providing a wide wavelength coverage in the near-infrared from roughly 0.8 - 1.7 μm. The parallel fields were observed through the optical ACS G800L grism. Taking advantage of the lensing magnification of the clusters, GLASS reaches excellent spectroscopic limits of ˜10-18 erg/s/cm2 and improved spatial resolution for lensed sources behind the clusters. These features are particularly useful for the three main science drivers of GLASS, which are: I) Use the hundreds of spectra of galaxies at z>6 to shed light on the epoch of reionization, the role galaxies play in reionizing the universe, and the Lyα escape fraction at the cosmic dawn. II) Study gas accretion, star formation, and outflows by spatially mapping resolved star formation and determine metallicity gradients from emission lines at z˜2. III) Explore the environmental dependence of galaxy evolution using the first comprehensive census of spatially resolved star formation in dense environments, i.e., the cluster cores as well as the cluster infall regions. The former two benefit highly from the improved depth and increased resolution provided by the cluster lensing. Apart from the main science drivers, a slew of ancillary science has been enabled by the survey. One particularly interesting example is the search for supernovae in the more than 40 GLASS visits, which resulted in the detection of the first multiple imaged supernova, SN Refsdal. I will present the survey, give an update on the current science results, in particular on the GLASS galaxies at the epoch of reionization, and provide a status report on the GLASS data releases, which are continuously being made available to the community.

  5. Spatial impulse response of a rectangular double curved transducer

    DEFF Research Database (Denmark)

    Bæk, David; Jensen, Jørgen Arendt; Willatzen, Morten

    2012-01-01

    Calculation of the pressure field from transducers having both a convex and a concave surface geometry is a complicated assignment that often is accomplished by subdividing the transducer surface into smaller flat elements of which the spatial impulse response is known. This method is often seen...... applied to curved transducers because an analytical solution is un-known. In this work a semi-analytical algorithm for the exact solution to a first order in diffraction effect of the spatial impulse response of rectangular shaped double curved transducers is presented. The algorithm and an approximation...... approximations ranging from 0.03 % to 0.8 % relative to a numerical solution for the spatial impulse response. It is shown that the presented algorithm gives consistent results with Field II for a linear flat, a linear focused, and a convex non-focused element. Best solution was found to be 0.01 % with a three...

  6. Optimal designs for dose response curves with common parameters

    OpenAIRE

    Feller, Chrystel; Schorning, Kirsten; Dette, Holger; Bermann, Georgina; Bornkamp, Björn

    2016-01-01

    A common problem in Phase II clinical trials is the comparison of dose response curves corresponding to different treatment groups. If the effect of the dose level is described by parametric regression models and the treatments differ in the administration frequency (but not in the sort of drug) a reasonable assumption is that the regression models for the different treatments share common parameters. This paper develops optimal design theory for the comparison of different regression models ...

  7. Parfocal wide field near infrared grism design and fabrication for WFIRST Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The original objective was to ensure that the grism assembly can be designed and fabricated to meet the WFIRST spectrometer requirements. The current grism design...

  8. Quantitative Dose-Response Curves from Subcellular Lipid Multilayer Microarrays

    Science.gov (United States)

    Kusi-Appiah, A. E.; Lowry, T. W.; Darrow, E. M.; Wilson, K.; Chadwick, B. P.; Davidson, M. W.; Lenhert, S.

    2015-01-01

    The dose-dependent bioactivity of small molecules on cells is a crucial factor in drug discovery and personalized medicine. Although small-molecule microarrays are a promising platform for miniaturized screening, it has been a challenge to use them to obtain quantitative dose-response curves in vitro, especially for lipophilic compounds. Here we establish a small-molecule microarray assay capable of controlling the dosage of small lipophilic molecules delivered to cells by varying the sub-cellular volumes of surface supported lipid micro- and nanostructure arrays fabricated with nanointaglio. Features with sub-cellular lateral dimensions were found necessary to obtain normal cell adhesion with HeLa cells. The volumes of the lipophilic drug-containing nanostructures were determined using a fluorescence microscope calibrated by atomic-force microscopy. We used the surface supported lipid volume information to obtain EC-50 values for the response of HeLa cells to three FDA-approved lipophilic anticancer drugs, docetaxel, imiquimod and triethylenemelamine, which were found to be significantly different from neat lipid controls. No significant toxicity was observed on the control cells surrounding the drug/lipid patterns, indicating lack of interference or leakage from the arrays. Comparison of the microarray data to dose-response curves for the same drugs delivered liposomally from solution revealed quantitative differences in the efficacy values, which we explain in terms of cell-adhesion playing a more important role in the surface-based assay. The assay should be scalable to a density of at least 10,000 dose response curves on the area of a standard microtiter plate. PMID:26167949

  9. Phase response curves for models of earthquake fault dynamics

    CERN Document Server

    Franović, Igor; Perc, Matjaz; Klinshov, Vladimir; Nekorkin, Vladimir; Kurths, Jürgen

    2016-01-01

    We systematically study effects of external perturbations on models describing earthquake fault dynamics. The latter are based on the framework of the Burridge-Knopoff spring-block system, including the cases of a simple mono-block fault, as well as the paradigmatic complex faults made up of two identical or distinct blocks. The blocks exhibit relaxation oscillations, which are representative for the stick-slip behavior typical for earthquake dynamics. Our analysis is carried out by determining the phase response curves of first and second order. For a mono-block fault, we consider the impact of a single and two successive pulse perturbations, further demonstrating how the profile of phase response curves depends on the fault parameters. For a homogeneous two-block fault, our focus is on the scenario where each of the blocks is influenced by a single pulse, whereas for heterogeneous faults, we analyze how the response of the system depends on whether the stimulus is applied to the block having a shorter or a ...

  10. Phase response curves for models of earthquake fault dynamics

    Science.gov (United States)

    Franović, Igor; Kostić, Srdjan; Perc, Matjaž; Klinshov, Vladimir; Nekorkin, Vladimir; Kurths, Jürgen

    2016-06-01

    We systematically study effects of external perturbations on models describing earthquake fault dynamics. The latter are based on the framework of the Burridge-Knopoff spring-block system, including the cases of a simple mono-block fault, as well as the paradigmatic complex faults made up of two identical or distinct blocks. The blocks exhibit relaxation oscillations, which are representative for the stick-slip behavior typical for earthquake dynamics. Our analysis is carried out by determining the phase response curves of first and second order. For a mono-block fault, we consider the impact of a single and two successive pulse perturbations, further demonstrating how the profile of phase response curves depends on the fault parameters. For a homogeneous two-block fault, our focus is on the scenario where each of the blocks is influenced by a single pulse, whereas for heterogeneous faults, we analyze how the response of the system depends on whether the stimulus is applied to the block having a shorter or a longer oscillation period.

  11. Measurement of infinitesimal phase response curves from noisy real neurons

    Science.gov (United States)

    Ota, Keisuke; Omori, Toshiaki; Watanabe, Shigeo; Miyakawa, Hiroyoshi; Okada, Masato; Aonishi, Toru

    2011-10-01

    We sought to measure infinitesimal phase response curves (iPRCs) from rat hippocampal CA1 pyramidal neurons. It is difficult to measure iPRCs from noisy neurons because of the dilemma that either the linearity or the signal-to-noise ratio of responses to external perturbations must be sacrificed. To overcome this difficulty, we used an iPRC measurement model formulated as the Langevin phase equation (LPE) to extract iPRCs in the Bayesian scheme. We then simultaneously verified the effectiveness of the measurement model and the reliability of the estimated iPRCs by demonstrating that LPEs with the estimated iPRCs could predict the stochastic behaviors of the same neurons, whose iPRCs had been measured, when they were perturbed by periodic stimulus currents. Our results suggest that the LPE is an effective model for real oscillating neurons and that many theoretical frameworks based on it may be applicable to real nerve systems.

  12. Interpretation of psychophysics response curves using statistical physics.

    Science.gov (United States)

    Knani, S; Khalfaoui, M; Hachicha, M A; Mathlouthi, M; Ben Lamine, A

    2014-05-15

    Experimental gustatory curves have been fitted for four sugars (sucrose, fructose, glucose and maltitol), using a double layer adsorption model. Three parameters of the model are fitted, namely the number of molecules per site n, the maximum response RM and the concentration at half saturation C1/2. The behaviours of these parameters are discussed in relationship to each molecule's characteristics. Starting from the double layer adsorption model, we determined (in addition) the adsorption energy of each molecule on taste receptor sites. The use of the threshold expression allowed us to gain information about the adsorption occupation rate of a receptor site which fires a minimal response at a gustatory nerve. Finally, by means of this model we could calculate the configurational entropy of the adsorption system, which can describe the order and disorder of the adsorbent surface.

  13. The analysis of dose-response curve from bioassays with quantal response: Deterministic or statistical approaches?

    Science.gov (United States)

    Mougabure-Cueto, G; Sfara, V

    2016-04-25

    Dose-response relations can be obtained from systems at any structural level of biological matter, from the molecular to the organismic level. There are two types of approaches for analyzing dose-response curves: a deterministic approach, based on the law of mass action, and a statistical approach, based on the assumed probabilities distribution of phenotypic characters. Models based on the law of mass action have been proposed to analyze dose-response relations across the entire range of biological systems. The purpose of this paper is to discuss the principles that determine the dose-response relations. Dose-response curves of simple systems are the result of chemical interactions between reacting molecules, and therefore are supported by the law of mass action. In consequence, the shape of these curves is perfectly sustained by physicochemical features. However, dose-response curves of bioassays with quantal response are not explained by the simple collision of molecules but by phenotypic variations among individuals and can be interpreted as individual tolerances. The expression of tolerance is the result of many genetic and environmental factors and thus can be considered a random variable. In consequence, the shape of its associated dose-response curve has no physicochemical bearings; instead, they are originated from random biological variations. Due to the randomness of tolerance there is no reason to use deterministic equations for its analysis; on the contrary, statistical models are the appropriate tools for analyzing these dose-response relations.

  14. CALUX measurements: statistical inferences for the dose-response curve.

    Science.gov (United States)

    Elskens, M; Baston, D S; Stumpf, C; Haedrich, J; Keupers, I; Croes, K; Denison, M S; Baeyens, W; Goeyens, L

    2011-09-30

    Chemical Activated LUciferase gene eXpression [CALUX] is a reporter gene mammalian cell bioassay used for detection and semi-quantitative analyses of dioxin-like compounds. CALUX dose-response curves for 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD] are typically smooth and sigmoidal when the dose is portrayed on a logarithmic scale. Non-linear regression models are used to calibrate the CALUX response versus TCDD standards and to convert the sample response into Bioanalytical EQuivalents (BEQs). Several complications may arise in terms of statistical inference, specifically and most important is the uncertainty assessment of the predicted BEQ. This paper presents the use of linear calibration functions based on Box-Cox transformations to overcome the issue of uncertainty assessment. Main issues being addressed are (i) confidence and prediction intervals for the CALUX response, (ii) confidence and prediction intervals for the predicted BEQ-value, and (iii) detection/estimation capabilities for the sigmoid and linearized models. Statistical comparisons between different calculation methods involving inverse prediction, effective concentration ratios (ECR(20-50-80)) and slope ratio were achieved with example datasets in order to provide guidance for optimizing BEQ determinations and expand assay performance with the recombinant mouse hepatoma CALUX cell line H1L6.1c3.

  15. LAMOST Spectrograph Response Curves: Stability and Application to Flux Calibration

    Science.gov (United States)

    Du, Bing; Luo, A.-Li; Kong, Xiao; Zhang, Jian-Nan; Guo, Yan-Xin; Cook, Neil James; Hou, Wen; Yang, Hai-Feng; Li, Yin-Bi; Song, Yi-Han; Chen, Jian-Jun; Zuo, Fang; Wu, Ke-Fei; Wang, Meng-Xin; Wu, Yue; Wang, You-Fen; Zhao, Yong-Heng

    2016-12-01

    The task of flux calibration for Large sky Area Multi-Object Spectroscopic Telescope (LAMOST) spectra is difficult due to many factors, such as the lack of standard stars, flat-fielding for large field of view, and variation of reddening between different stars, especially at low Galactic latitudes. Poor selection, bad spectral quality, or extinction uncertainty of standard stars not only might induce errors to the calculated spectral response curve (SRC) but also might lead to failures in producing final 1D spectra. In this paper, we inspected spectra with Galactic latitude | b| ≥slant 60^\\circ and reliable stellar parameters, determined through the LAMOST Stellar Parameter Pipeline (LASP), to study the stability of the spectrograph. To guarantee that the selected stars had been observed by each fiber, we selected 37,931 high-quality exposures of 29,000 stars from LAMOST DR2, and more than seven exposures for each fiber. We calculated the SRCs for each fiber for each exposure and calculated the statistics of SRCs for spectrographs with both the fiber variations and time variations. The result shows that the average response curve of each spectrograph (henceforth ASPSRC) is relatively stable, with statistical errors ≤10%. From the comparison between each ASPSRC and the SRCs for the same spectrograph obtained by the 2D pipeline, we find that the ASPSRCs are good enough to use for the calibration. The ASPSRCs have been applied to spectra that were abandoned by the LAMOST 2D pipeline due to the lack of standard stars, increasing the number of LAMOST spectra by 52,181 in DR2. Comparing those same targets with the Sloan Digital Sky Survey (SDSS), the relative flux differences between SDSS spectra and LAMOST spectra with the ASPSRC method are less than 10%, which underlines that the ASPSRC method is feasible for LAMOST flux calibration.

  16. [Dose response curve of paclitaxel measured by histoculture drug response assay].

    Science.gov (United States)

    Yoshimasu, Tatsuya; Oura, Shoji; Hirai, Issei; Kokawa, Yozo; Okamura, Yoshitaka; Furukawa, Tomoko

    2005-04-01

    Dose response curves of paclitaxel were measured by histoculture drug response assay (HDRA) in 11 lung cancer patients. Inhibition rates of paclitaxel at several concentrations were measured and fitted to the sigmoid dose response curve, using non-linear least square analysis, with fitting equation y=A (1-1/(1+exp (b (x-log (ED50)). Parameters A, b, and ED50 were 88.3+/-6.0 (80.0-100.0) %, 9.57+/-4.32 (2.25-15.0), and 26.8+/-8.1 (15.0-41.0) microg/ml, respectively. The parameter b was lower in well-differentiated tumors compared with moderately and poorly-differentiated tumors. Dose response curves of paclitaxel could be measured by HDRA in lung cancer. This method provides us more information for drug sensitivity than the usual HDRA method. This may lead to the improved accuracy of HDRA.

  17. Ramsay-Curve Item Response Theory for the Three-Parameter Logistic Item Response Model

    Science.gov (United States)

    Woods, Carol M.

    2008-01-01

    In Ramsay-curve item response theory (RC-IRT), the latent variable distribution is estimated simultaneously with the item parameters of a unidimensional item response model using marginal maximum likelihood estimation. This study evaluates RC-IRT for the three-parameter logistic (3PL) model with comparisons to the normal model and to the empirical…

  18. In search of a phase response curve for lithium chloride

    Energy Technology Data Exchange (ETDEWEB)

    Readey, M.A.; Groh, K.R.; Ehret, C.F.

    1987-01-01

    Male rats were free-run, and one day later were exposed to a single, punctate dose of 5 mM LiCl/kg body weight by injection at one of eight equally spaced times throughout the 24-h period. For each of the six days following injection, a separate phase response curve was derived from core-temperature chronograms. Unlike the classical response induced by chronobiotics such as dexamethasone, alpha-methyl-para-tyrosine, and theophylline, statistically significant phase shifts for lithium were observed only on the first day following injection. These induced phase changes were not permanent, but instead were transient. By the sixth day of free-run, all experimental rats had drifted to the control acrophase; i.e., by the end of the experiment, most of the treated rats again had phase and confidence arcs not significantly different from their controls. The confidence arcs of the acrophases of the individual animals on the subsequent days post injection reveal that in this experiment, lithium was transiently dyschronogenic rather than definitively chronobiotic. The results suggest that punctate rather than chronic administration of lithium, followed by strict orthochronal administration of traditional zeitgebers, would be an effective way of restoring circadian synchrony in an internally desynchronized system. 122 refs.

  19. An item response curves analysis of the Force Concept Inventory

    Science.gov (United States)

    Morris, Gary A.; Harshman, Nathan; Branum-Martin, Lee; Mazur, Eric; Mzoughi, Taha; Baker, Stephen D.

    2012-09-01

    Several years ago, we introduced the idea of item response curves (IRC), a simplistic form of item response theory (IRT), to the physics education research community as a way to examine item performance on diagnostic instruments such as the Force Concept Inventory (FCI). We noted that a full-blown analysis using IRT would be a next logical step, which several authors have since taken. In this paper, we show that our simple approach not only yields similar conclusions in the analysis of the performance of items on the FCI to the more sophisticated and complex IRT analyses but also permits additional insights by characterizing both the correct and incorrect answer choices. Our IRC approach can be applied to a variety of multiple-choice assessments but, as applied to a carefully designed instrument such as the FCI, allows us to probe student understanding as a function of ability level through an examination of each answer choice. We imagine that physics teachers could use IRC analysis to identify prominent misconceptions and tailor their instruction to combat those misconceptions, fulfilling the FCI authors' original intentions for its use. Furthermore, the IRC analysis can assist test designers to improve their assessments by identifying nonfunctioning distractors that can be replaced with distractors attractive to students at various ability levels.

  20. Latent Growth Curve Models for Biomarkers of the Stress Response

    Directory of Open Access Journals (Sweden)

    John M. Felt

    2017-06-01

    Full Text Available Objective: The stress response is a dynamic process that can be characterized by predictable biochemical and psychological changes. Biomarkers of the stress response are typically measured over time and require statistical methods that can model change over time. One flexible method of evaluating change over time is the latent growth curve model (LGCM. However, stress researchers seldom use the LGCM when studying biomarkers, despite their benefits. Stress researchers may be unaware of how these methods can be useful. Therefore, the purpose of this paper is to provide an overview of LGCMs in the context of stress research. We specifically highlight the unique benefits of using these approaches.Methods: Hypothetical examples are used to describe four forms of the LGCM.Results: The following four specifications of the LGCM are described: basic LGCM, latent growth mixture model, piecewise LGCM, and LGCM for two parallel processes. The specifications of the LGCM are discussed in the context of the Trier Social Stress Test. Beyond the discussion of the four models, we present issues of modeling nonlinear patterns of change, assessing model fit, and linking specific research questions regarding biomarker research using different statistical models.Conclusions: The final sections of the paper discuss statistical software packages and more advanced modeling capabilities of LGCMs. The online Appendix contains example code with annotation from two statistical programs for the LCGM.

  1. Maximum likelihood estimation for cytogenetic dose-response curves

    Energy Technology Data Exchange (ETDEWEB)

    Frome, E.L; DuFrain, R.J.

    1983-10-01

    In vitro dose-response curves are used to describe the relation between the yield of dicentric chromosome aberrations and radiation dose for human lymphocytes. The dicentric yields follow the Poisson distribution, and the expected yield depends on both the magnitude and the temporal distribution of the dose for low LET radiation. A general dose-response model that describes this relation has been obtained by Kellerer and Rossi using the theory of dual radiation action. The yield of elementary lesions is kappa(..gamma..d + g(t, tau)d/sup 2/), where t is the time and d is dose. The coefficient of the d/sup 2/ term is determined by the recovery function and the temporal mode of irradiation. Two special cases of practical interest are split-dose and continuous exposure experiments, and the resulting models are intrinsically nonlinear in the parameters. A general purpose maximum likelihood estimation procedure is described and illustrated with numerical examples from both experimental designs. Poisson regression analysis is used for estimation, hypothesis testing, and regression diagnostics. Results are discussed in the context of exposure assessment procedures for both acute and chronic human radiation exposure.

  2. LAMOST Spectrograph Response Curves: Stability and Application to flux calibration

    CERN Document Server

    Du, Bing; Bai, Zhong-Rui; Kong, Xiao; Zhang, Jian-Nan; Guo, Yan-Xin; Cook, Neil James; Hou, Wen; Yang, Hai-Feng; Li, Yin-Bi; Song, Yi-Han; Chen, Jian-Jun; Zuo, Fang; Wu, Ke-Fei; Wang, Meng-Xin; Wang, You-Fen; Zhao, Yong-Heng

    2016-01-01

    The task of flux calibration for LAMOST (Large sky Area Multi-Object Spectroscopic Telescope) spectra is difficult due to many factors. For example, the lack of standard stars, flat fielding for large field of view, and variation of reddening between different stars especially at low galactic latitudes etc. Poor selection, bad spectral quality, or extinction uncertainty of standard stars not only might induce errors to the calculated spectral response curve (SRC), but also might lead to failures in producing final 1D spectra. In this paper, we inspected spectra with Galactic latitude |b|>=60 degree and reliable stellar parameters, determined through the LAMOST Stellar Parameter Pipeline (LASP), to study the stability of the spectrograph. To guarantee the selected stars had been observed by each fiber, we selected 37,931 high quality exposures of 29,000 stars from LAMOST DR2, and more than 7 exposures for each fiber. We calculated the SRCs for each fiber for each exposure, and calculated the statistics of SRCs...

  3. Human Adolescent Phase Response Curves to Bright White Light.

    Science.gov (United States)

    Crowley, Stephanie J; Eastman, Charmane I

    2017-08-01

    Older adolescents are particularly vulnerable to circadian misalignment and sleep restriction, primarily due to early school start times. Light can shift the circadian system and could help attenuate circadian misalignment; however, a phase response curve (PRC) to determine the optimal time for receiving light and avoiding light is not available for adolescents. We constructed light PRCs for late pubertal to postpubertal adolescents aged 14 to 17 years. Participants completed 2 counterbalanced 5-day laboratory sessions after 8 or 9 days of scheduled sleep at home. Each session included phase assessments to measure the dim light melatonin onset (DLMO) before and after 3 days of free-running through an ultradian light-dark (wake-sleep) cycle (2 h dim [~20 lux] light, 2 h dark). In one session, intermittent bright white light (~5000 lux; four 20-min exposures) was alternated with 10 min of dim room light once per day for 3 consecutive days. The time of light varied among participants to cover the 24-h day. For each individual, the phase shift to bright light was corrected for the free-run derived from the other laboratory session with no bright light. One PRC showed phase shifts in response to light start time relative to the DLMO and another relative to home sleep. Phase delay shifts occurred around the hours corresponding to home bedtime. Phase advances occurred during the hours surrounding wake time and later in the afternoon. The transition from delays to advances occurred at the midpoint of home sleep. The adolescent PRCs presented here provide a valuable tool to time bright light in adolescents.

  4. Optical verification tests of the NISP/Euclid grism qualification model

    Science.gov (United States)

    Caillat, Amandine; Costille, Anne; Pascal, Sandrine; Vives, Sébastien; Rossin, Christelle; Sanchez, Patrice; Foulon, Benjamin

    2016-07-01

    The Euclid space mission aims at elucidating dark matter and dark energy mysteries thanks to two scientific instruments: VIS, the visible camera and NISP, the Near Infrared Spectro-Photometer. Millions of galaxies spectra will be recorded thanks to its spectroscopic mode using four grisms developed under LAM (Laboratoire d'Astrophysique de Marseille) responsibility. These dispersive optical components are made of a grating on a prism and include also, specifically for NISP, three other optical functions: spectral filtering, focus adjustment and spectral wavefront correction. Therefore, these optical elements are very challenging to manufacture (four industrial partners work on a single optical component) and to test before integration into NISP. In this paper, first we describe the optical specifications and the manufacturing process. Second, we explain the optical validation tests campaign: optical setups, measurements and data processing procedures used to validate these complex optical components, particularly for transmitted efficiency and wavefront error for which specifications are very stringent. Finally, we present the first results obtained on the grism EQM which manufacturing is on-going and almost finished.

  5. HST WFC3 Early Release Science: Emission-Line Galaxies from IR Grism Observations

    CERN Document Server

    Straughn, A N; Kuemmel, M; Walsh, J R; Cohen, S H; Gardner, J P; Windhorst, R A; O'Connell, R W; Pirzkal, N; Meurer, G; McCarthy, P J; Hathi, N P; Malhotra, S; Rhoads, J; Balick, B; Bond, H E; Calzetti, D; Disney, M J; Dopita, M A; Frogel, J A; Hall, D N B; Holtzman, J A; Kimble, R A; Luppino, G; Paresce, F; Saha, A; Silk, J I; Trauger, J T; Walker, A R; Whitmore, B C; Young, E T

    2010-01-01

    We present grism spectra of emission--line galaxies (ELGs) from 0.6--1.6 microns from the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST). These new infrared grism data augment previous optical Advanced Camera for Surveys G800L (0.6--0.95 micron) grism data in GOODS--South, extending the wavelength covereage well past the G800L red cutoff. The ERS grism field was observed at a depth of 2 orbits per grism, yielding spectra of hundreds of faint objects, a subset of which are presented here. ELGs are studied via the \\Ha, \\OIII, and \\OII\\ emission lines detected in the redshift ranges 0.2$\\cle$z$\\cle$1.6, 1.2$\\cle$z$\\cle$2.4 and 2.0$\\cle$z$\\cle$3.6 respectively in the G102 (0.8--1.1 microns; R$\\sim$210) and G141 (1.1--1.6 microns; R$\\sim$130) grisms. The higher spectral resolution afforded by the WFC3 grisms also reveals emission lines not detectable with the G800L grism (e.g., \\SII\\ and \\SIII\\ lines). From these relatively shallow observations, line luminosities, star--formation rates, and grism s...

  6. Effects of mistuning and matrix structure on the topology of frequency response curves

    Science.gov (United States)

    Afolabi, Dare

    1989-01-01

    The stability of a frequency response curve under mild perturbations of the system's matrix is investigated. Using recent developments in the theory of singularities of differentiable maps, it is shown that the stability of a response curve depends on the structure of the system's matrix. In particular, the frequency response curves of a cylic system are shown to be unstable. Consequently, slight parameter variations engendered by mistuning will induce a significant difference in the topology of the forced response curves, if the mistuning transformation crosses the bifurcation set.

  7. Infrared Testing of the Wide-field Infrared Survey Telescope Grism Using Computer Generated Holograms

    Science.gov (United States)

    Dominguez, Margaret Z.; Content, David A.; Gong, Qian; Griesmann, Ulf; Hagopian, John G.; Marx, Catherine T; Whipple, Arthur L.

    2017-01-01

    Infrared Computer Generated Holograms (CGHs) were designed, manufactured and used to measure the performance of the grism (grating prism) prototype which includes testing Diffractive Optical Elements (DOE). The grism in the Wide Field Infrared Survey Telescope (WFIRST) will allow the surveying of a large section of the sky to find bright galaxies.

  8. Performance characteristics of two volume phase holographic grisms produced for the ESPRESSO spectrograph

    Science.gov (United States)

    Arns, James A.

    2016-08-01

    The ESPRESSO spectrograph [1], a new addition to the European Southern Observatory's (ESO) Very Large Telescope (VLT), requires two volume phase holographic (VPH) grisms, one blue and the other red, splitting the overall spectral range of the instrument to maximize throughput while achieving high resolution. The blue grism covers the spectral range from 375 nm to 520 nm with a dispersion of 0.88 degrees/nm at the central wavelength of 438 nm. The red grism operates from 535 nm to 780 nm with a dispersion of 0.47 degrees/nm at 654.8 nm. Both designs use a single input prism to enhance the dispersion of the grism assembly. The grisms are relatively large in size with a working aperture of 185 mm x 185 mm for the blue grism and 215 nm x 185 mm for the red grism respectively. This paper describes the specifications of the two grating types, gives the rigorous coupled wave analysis (RCWA) theoretical performances of diffraction efficiency for the production designs and presents the measured performances of each of the delivered grisms.

  9. Final design of the grism cryogenic mount for the Euclid-NISP mission

    Science.gov (United States)

    Rossin, Christelle; Costille, Anne; Caillat, Amandine; Pascal, Sandrine; Sanchez, Patrice; Foulon, Benjamin; Vives, Sebastien; Zavattini, Lorenzo; Moroni, Andrea; Radaelli, Paolo

    2016-07-01

    The grism mount design for the Euclid-NISP mission was studied to maintain optical performances and alignment at cryogenic temperature, and to survive to launch vibrations. An Invar mount with strong weight-relief bonded to the Silica grism through tangential blades has been designed. In spring 2015 we proceeded to thermal cycling and vibration tests to successfully qualify the Grism Engineering Model in the Euclid space environment. Thanks to detailed Finite Element analyses, we correlated simulations and tests. Now that phase C began, we are manufacturing the Engineering and Qualification Model and the four Flight Models. Thus, random coupled analyses of the grisms on the complete wheel assembly and impact of interface preloads on the grism behavior have also been studied.

  10. Confidence Bands for the Three-Parameter Logistic Item Response Curve.

    Science.gov (United States)

    Lord, Frederic M.; Pashley, Peter J.

    A large sample method for obtaining asymptotic simultaneous confidence bands for a three-parameter logistic response curve is described. Simultaneous confidence bands indicate the sampling variation of item response curves relative to a fitted function. A procedure is given which requires as input maximum likelihood parameter estimates and an…

  11. Modeling and regression analysis of semiochemical dose-response curves of insect antennal reception and behavior

    Science.gov (United States)

    Dose-response curves with semiochemicals are reported in many articles in insect chemical ecology regarding neurophysiology and behavioral bioassays. Most such curves are shown in figures where the x-axis has order of magnitude increases in dosages versus responses on the y-axis represented by point...

  12. Wayne - A Simulator for HST WFC3 IR Grism Spectroscopy

    CERN Document Server

    Varley, R

    2015-01-01

    Wayne is an algorithm that simulates Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3) grism spectroscopic frames including sources of noise and systematics. It can simulate both staring and spatial scan modes, and observations such as the transit and eclipse of exoplanets. Unlike many other instrument simulators, the focus of Wayne is on creating frames with realistic systematics in order to test the effectiveness of different data analysis methods in a variety of different scenarios. This approach is critical for method validation and optimising observing strategies. In this paper we describe Wayne's implementation for WFC3 in the near-infrared channel with the G141 and G102 grisms. We compare the simulations to real data, obtained for the exoplanet HD 209458b to verify the accuracy of the simulation. The simulated data described in this paper is available now at www.ucl.ac.uk/exoplanets/wayne/. We plan to release this tool to the community as open source software in the near future.

  13. FIGS—Faint Infrared Grism Survey: Description and Data Reduction

    Science.gov (United States)

    Pirzkal, Norbert; Malhotra, Sangeeta; Ryan, Russell E.; Rothberg, Barry; Grogin, Norman; Finkelstein, Steven L.; Koekemoer, Anton M.; Rhoads, James; Larson, Rebecca L.; Christensen, Lise; Cimatti, Andrea; Ferreras, Ignacio; Gardner, Jonathan P.; Gronwall, Caryl; Hathi, Nimish P.; Hibon, Pascale; Joshi, Bhavin; Kuntschner, Harald; Meurer, Gerhardt R.; O’Connell, Robert W.; Oestlin, Goeran; Pasquali, Anna; Pharo, John; Straughn, Amber N.; Walsh, Jeremy R.; Watson, Darach; Windhorst, Rogier A.; Zakamska, Nadia L.; Zirm, Andrew

    2017-09-01

    The Faint Infrared Grism Survey (FIGS) is a deep Hubble Space Telescope (HST) WFC3/IR (Wide Field Camera 3 Infrared) slitless spectroscopic survey of four deep fields. Two fields are located in the Great Observatories Origins Deep Survey-North (GOODS-N) area and two fields are located in the Great Observatories Origins Deep Survey-South (GOODS-S) area. One of the southern fields selected is the Hubble Ultra Deep Field. Each of these four fields were observed using the WFC3/G102 grism (0.8 μm–1.15 μm continuous coverage) with a total exposure time of 40 orbits (≈100 kilo-seconds) per field. This reaches a 3σ continuum depth of ≈ 26 AB magnitudes and probes emission lines to ∼ {10}-17 {erg} {{{s}}}-1 {{cm}}-2. This paper details the four FIGS fields and the overall observational strategy of the project. A detailed description of the Simulation Based Extraction (SBE) method used to extract and combine over 10,000 spectra of over 2000 distinct sources brighter than {m}F105W=26.5 mag is provided. High fidelity simulations of the observations is shown to significantly improve the background subtraction process, the spectral contamination estimates, and the final flux calibration. This allows for the combination of multiple spectra to produce a final high quality, deep, 1D spectra for each object in the survey.

  14. A Grid Algorithm for High Throughput Fitting of Dose-Response Curve Data

    OpenAIRE

    Wang, Yuhong; Jadhav, Ajit; Southal, Noel; Huang, Ruili; Nguyen, Dac-Trung

    2010-01-01

    We describe a novel algorithm, Grid algorithm, and the corresponding computer program for high throughput fitting of dose-response curves that are described by the four-parameter symmetric logistic dose-response model. The Grid algorithm searches through all points in a grid of four dimensions (parameters) and finds the optimum one that corresponds to the best fit. Using simulated dose-response curves, we examined the Grid program’s performance in reproducing the actual values that were used ...

  15. Interpreting 'dose-response' curves using homeodynamic data: with an improved explanation for hormesis.

    Science.gov (United States)

    Stebbing, A R D

    2009-04-15

    A re-interpretation of the 'dose-response' curve is given that accommodates homeostasis. The outcome, or overall effect, of toxicity is the consequence of toxicity that is moderated by homeodynamic responses. Equilibrium is achieved by a balance of opposing forces of toxic inhibition countered by a stimulatory response. A graphical model is given consisting of two linked curves (response vs concentration and effect vs concentration), which provide the basis for a re-interpretation of the 'dose-response' curve. The model indicates that such relationships are non-linear with a threshold, which is due to homeodynamic responses. Subthreshold concentrations in 'dose-response' curves provide the sum of toxic inhibition minus the homeodynamic response; the response itself is unseen in serving its purpose of neutralizing perturbation. This interpretation suggests why the alpha- and beta-curves are non-linear. The beta-curve indicates adaptive overcorrection to toxicity that confers greater resistance to subsequent toxic exposure, with hormesis as an epiphenomenon.

  16. Driver Vision Based Perception-Response Time Prediction and Assistance Model on Mountain Highway Curve

    Science.gov (United States)

    Li, Yi; Chen, Yuren

    2016-01-01

    To make driving assistance system more humanized, this study focused on the prediction and assistance of drivers’ perception-response time on mountain highway curves. Field tests were conducted to collect real-time driving data and driver vision information. A driver-vision lane model quantified curve elements in drivers’ vision. A multinomial log-linear model was established to predict perception-response time with traffic/road environment information, driver-vision lane model, and mechanical status (last second). A corresponding assistance model showed a positive impact on drivers’ perception-response times on mountain highway curves. Model results revealed that the driver-vision lane model and visual elements did have important influence on drivers’ perception-response time. Compared with roadside passive road safety infrastructure, proper visual geometry design, timely visual guidance, and visual information integrality of a curve are significant factors for drivers’ perception-response time. PMID:28042851

  17. Driver Vision Based Perception-Response Time Prediction and Assistance Model on Mountain Highway Curve

    Directory of Open Access Journals (Sweden)

    Yi Li

    2016-12-01

    Full Text Available To make driving assistance system more humanized, this study focused on the prediction and assistance of drivers’ perception-response time on mountain highway curves. Field tests were conducted to collect real-time driving data and driver vision information. A driver-vision lane model quantified curve elements in drivers’ vision. A multinomial log-linear model was established to predict perception-response time with traffic/road environment information, driver-vision lane model, and mechanical status (last second. A corresponding assistance model showed a positive impact on drivers’ perception-response times on mountain highway curves. Model results revealed that the driver-vision lane model and visual elements did have important influence on drivers’ perception-response time. Compared with roadside passive road safety infrastructure, proper visual geometry design, timely visual guidance, and visual information integrality of a curve are significant factors for drivers’ perception-response time.

  18. Driver Vision Based Perception-Response Time Prediction and Assistance Model on Mountain Highway Curve.

    Science.gov (United States)

    Li, Yi; Chen, Yuren

    2016-12-30

    To make driving assistance system more humanized, this study focused on the prediction and assistance of drivers' perception-response time on mountain highway curves. Field tests were conducted to collect real-time driving data and driver vision information. A driver-vision lane model quantified curve elements in drivers' vision. A multinomial log-linear model was established to predict perception-response time with traffic/road environment information, driver-vision lane model, and mechanical status (last second). A corresponding assistance model showed a positive impact on drivers' perception-response times on mountain highway curves. Model results revealed that the driver-vision lane model and visual elements did have important influence on drivers' perception-response time. Compared with roadside passive road safety infrastructure, proper visual geometry design, timely visual guidance, and visual information integrality of a curve are significant factors for drivers' perception-response time.

  19. Methodology of light response curves: application of chlorophyll fluorescence to microphytobenthic biofilms

    NARCIS (Netherlands)

    Herlory, O.; Richard, P.; Blanchard, G.F.

    2007-01-01

    The light response curve methodology for microphytobenthic biofilms was studied by comparing the two most usual approaches used in pulse amplitude modulated (PAM) fluorometry. The non-sequential light curve (N-SLC) method is characterized by independent measures of the photosynthetic activity across

  20. Spatial Finite Element Analysis for Dynamic Response of Curved Thin-Walled Box Girder Bridges

    Directory of Open Access Journals (Sweden)

    Yinhui Wang

    2016-01-01

    Full Text Available According to the flexural and torsional characteristics of curved thin-walled box girder with the effect of initial curvature, 7 basic displacements of curved box girder are determined. And then the strain-displacement calculation correlations were established. Under the curvilinear coordinate system, a three-noded curved girder finite element which has 7 degrees of freedom per node for the vibration characteristic and dynamic response analysis of curved box girder is constructed. The shape functions are used as the interpolation functions of variable curvature and variable height to accommodate to the variation of curvature and section height. A MATLAB numerical analysis program has been implemented.

  1. New, Efficient High-Resolution Red VPH Grisms in VIMOS

    Science.gov (United States)

    Marconi, Gianni; Bagnulo, Stefano; Lizon, Jean-Louis; Buzzoni, Bernard; Dekker, Hans; D'Odorico, Sandro; Izzo, Carlo; Wolff, Burkhard F.

    2006-06-01

    VIMOS is the visible (360 to 1000 nm) wide-field imager and multi-object spectrograph mounted on the Nasmyth focus B of Melipal (UT3) (Le Fèvre et al. 2003). The instrument is comprised of four identical arms each with a field of view of 7' × 8' with a 0.205' pixel size and a gap between each quadrant of ~ 2'. Each arm is equipped with six grisms providing a spectral resolution range from ~ 200-2500 and with an EEV 44-82, thinned, anti-reflection coated, 4k × 2k pixel CCD. VIMOS operates in three different modes: Imaging (IMG), Multi-Object Spectroscopy (MOS), and with Integral Field Unit (IFU). For a summary of the instrument capability and performance, see http://www.eso.org/instruments/vimos/.

  2. A grid algorithm for high throughput fitting of dose-response curve data.

    Science.gov (United States)

    Wang, Yuhong; Jadhav, Ajit; Southal, Noel; Huang, Ruili; Nguyen, Dac-Trung

    2010-10-21

    We describe a novel algorithm, Grid algorithm, and the corresponding computer program for high throughput fitting of dose-response curves that are described by the four-parameter symmetric logistic dose-response model. The Grid algorithm searches through all points in a grid of four dimensions (parameters) and finds the optimum one that corresponds to the best fit. Using simulated dose-response curves, we examined the Grid program's performance in reproducing the actual values that were used to generate the simulated data and compared it with the DRC package for the language and environment R and the XLfit add-in for Microsoft Excel. The Grid program was robust and consistently recovered the actual values for both complete and partial curves with or without noise. Both DRC and XLfit performed well on data without noise, but they were sensitive to and their performance degraded rapidly with increasing noise. The Grid program is automated and scalable to millions of dose-response curves, and it is able to process 100,000 dose-response curves from high throughput screening experiment per CPU hour. The Grid program has the potential of greatly increasing the productivity of large-scale dose-response data analysis and early drug discovery processes, and it is also applicable to many other curve fitting problems in chemical, biological, and medical sciences.

  3. A Lyman Break Galaxy in the Epoch of Reionization from Hubble Space Telescope (HST) Grism Spectroscopy

    Science.gov (United States)

    Rhoads, James E.; Malhotra, Sangeeta; Stern, Daniel K.; Gardner, Jonathan P.; Dickinson, Mark; Pirzkal, Norbert; Spinrad, Hyron; Reddy, Naveen; Dey, Arjun; Hathi, Nimish; hide

    2013-01-01

    Slitless grism spectroscopy from space offers dramatic advantages for studying high redshift galaxies: high spatial resolution to match the compact sizes of the targets, a dark and uniform sky background, and simultaneous observation over fields ranging from five square arcminutes (HST) to over 1000 square arcminutes (Euclid). Here we present observations of a galaxy at z = 6.57 the end of the reioinization epoch identified using slitless HST grism spectra from the PEARS survey (Probing Evolution And Reionization Spectroscopically) and reconfirmed with Keck + DEIMOS. This high redshift identification is enabled by the depth of the PEARS survey. Substantially higher redshifts are precluded for PEARS data by the declining sensitivity of the ACS grism at greater than lambda 0.95 micrometers. Spectra of Lyman breaks at yet higher redshifts will be possible using comparably deep observations with IR-sensitive grisms.

  4. Optical gratings and grisms: developments on straylight and polarization sensitivity improved microstructures

    Science.gov (United States)

    Diehl, Torsten; Triebel, Peter; Moeller, Tobias; Gatto, Alexandre; Pesch, Alexander; Erdmann, Lars H.; Burkhardt, Matthias; Kalies, Alexander

    2015-09-01

    Spectral imaging systems lead to enhanced sensing properties when the sensing system provides sufficient spectral resolution to identify materials from its spectral reflectance signature. The performance of diffraction gratings provides an initial way to improve instrumental resolution. Thus, subsequent manufacturing techniques of high quality gratings are essential to significantly improve the spectral performance. The ZEISS unique technology of manufacturing real-blazed profiles comprising transparent substrates is well suited for the production of transmission gratings. In order to reduce high order aberrations, aspherical and free-form surfaces can be alternatively processed to allow more degrees of freedom in the optical design of spectroscopic instruments with less optical elements and therefore size and weight advantages. Prism substrates were used to manufacture monolithic GRISM elements for UV to IR spectral range. Many years of expertise in the research and development of optical coatings enable high transmission anti-reflection coatings from the DUV to the NIR. ZEISS has developed specially adapted coating processes (Ion beam sputtering, ion-assisted deposition and so on) for maintaining the micro-structure of blazed gratings in particular. Besides of transmission gratings, numerous spectrometer setups (e.g. Offner, Rowland circle, Czerny-Turner system layout) working on the optical design principles of reflection gratings. This technology steps can be applied to manufacture high quality reflection gratings from the EUV to the IR applications with an outstanding level of low stray light and ghost diffraction order by employing a combination of holography and reactive ion beam etching together with the in-house coating capabilities. We report on results of transmission, reflection gratings on plane and curved substrates and GRISM elements with enhanced efficiency of the grating itself combined with low scattered light in the angular distribution. Focusing

  5. Dose-Response Curve of Chromosome Aberrations in Human Lymphocytes Induced by Gamma-Rays

    Directory of Open Access Journals (Sweden)

    Y. Lusiyanti

    2013-12-01

    Full Text Available Chromosome aberration is a biomarker to predict the level of cell damage caused by exposure to ionizing radiation on human body. Dicentric chromosome is a specific chromosome aberration caused by ionizing radiation and is used as a gold standard biodosimetry of individuals over exposed to ionizing radiation. In radiation accident the dicentric assays has been applied as biological dosimetry to estimate radiation absorbed dose and also to confirm the radiation dose received to radiation workers.The purpose of this study was to generate a dose response curve of chromosome aberration (dicentric in human lymphocyte induced by gamma radiation. Peripheral blood samples from three non smoking healthy volunteers aged between 25-48 years old with informed consent were irradiated with dose between 0.1-4.0 Gy and a control using gamma teletherapy source. The culture procedure was conducted following the IAEA standard procedures with slight modifications. Analysis of dose-response curves used was LQ model Y = a + αD + βD2. The result showed that α and β values of the curve obtained were 0.018 ± 0.006 and 0.013 ± 0.002, respectively. Dose response calibration curve for dicentric chromosome aberrations in human lymphocytes induced by gamma-radiation fitted to linear quadratic model. In order to apply the dose response curve of chromosome aberration disentric for biodosimetry, this standar curve still need to be validated.

  6. Evaluation of optimum profile modification curves of profile shifted spur gears based on vibration responses

    Science.gov (United States)

    Ma, Hui; Pang, Xu; Feng, Ranjiao; Wen, Bangchun

    2016-03-01

    In this paper, a mesh stiffness model is developed for profile shifted gears with addendum modifications and tooth profile modifications (TPMs). The time-varying mesh stiffness (TVMS), load sharing factor (LSF), loaded static transmission error (LSTE) and non-loaded static transmission error (NLSTE) of a profile shifted spur gear pair with TPMs are obtained by the analytical model. The optimum profile modification curve under different amounts of TPM is determined by analyzing the LSTE first. Then, considering the effect of NLSTE, finite element (FE) model of a geared rotor system is established. The system vibration responses under different TPM curves are analyzed and the optimum modification curve is further evaluated by amplitude frequency responses. The results show that the optimum modification curve is related to the amount of TPM and modification coefficients. The comparison of the optimum profile modification curves is evaluated by LSTE and vibration responses, which shows that the optimum modification curve should be determined by evaluating the vibration response of the geared rotor system in the low mesh frequency range.

  7. Grism Performance for Mid-IR (5-40 microns) Spectroscopy

    Science.gov (United States)

    Ennico, K. A.; Mar, D. J.; Jaffe, D. T.; Marsh, J. P.; Keller, L. D.; Herter, T. L.; Greene, T. P.; Adams, J. D.

    2006-01-01

    Grisms provide a straightforward method to transform an imager into a spectrometer with little change to the original imaging optics. This paper addresses the performance of a suite of grisms as part of an Astrobiology Science and Instrument Development (ASTID) Program to implement a moderate resolution spectroscopic capability to the mid/far-IR facility instrument FORCAST for the Stratospheric Observatory For Infrared Astronomy (SOFIA) [see accompanying abstract by Adams et al.]. A moderate resolution mid-IR spectrometer on SOFIA will offer advantages not available to either ground or space-based instruments after the Spitzer Space Telescope ceases operation in approx. 2007. SOFIA will begin operations in 2007 and will have an operational lifetime of approx. 20 years. From aircraft altitudes, it will be possible to cover a range of wavelengths, particularly in the critical 5-9 micron band, where detection of astrobiologically interesting molecules have key spectral signatures, that are not accessible from the ground. This grism suite consists of six grisms: four monolithic Si grisms [see accompanying abstract by Mar et al.] and two KRS-5 grisms. These devices will allow long slit low-resolution and short slit, cross-dispersed high-resolution spectroscopic modes selectable by simply moving the camera filter wheels. This configuration will enable observing programs to gather images and spectra in a single SOFIA flight. The four silicon grisms, whose performance is highlighted in this paper, will operate in the following wavelength ranges: 5-8, 17-28, and 28-37 microns. In the 5-8 micron range, R=1200 is achievable for a 2 arcsecond slit using the grism as a cross-disperser. For the 17-28 and 28-37 micron ranges, the resolving powers are R approx. 130, 250 when used in low orders with a slit of 3 arcseconds. The silicon grisms demonstrate a new family of dispersive elements with good optical performance for spectroscopy from 1.2-8 micron and beyond 18 microns

  8. Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk

    DEFF Research Database (Denmark)

    Hulman, Adam; Simmons, Rebecca Kate; Vistisen, Dorte

    2017-01-01

    We aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response curve groups. We analyzed data from 1,267 individuals without diabetes from five studies...... in Denmark, the Netherlands and the USA. Each study included between 5 and 11 measurements at different time points during a 2-h oral glucose tolerance test, resulting in 9,602 plasma glucose measurements. Latent class trajectories with a cubic specification for time were fitted to identify different...... patterns of plasma glucose change during the oral glucose tolerance test. Cardiometabolic risk factor profiles were compared between the identified groups. Using latent class trajectory analysis, five glucose response curves were identified. Despite similar fasting and 2-h values, glucose peaks and peak...

  9. Electromechanical response of a curved piezoelectric nanobeam with the consideration of surface effects

    Energy Technology Data Exchange (ETDEWEB)

    Yan Zhi; Jiang Liying, E-mail: lyjiang@eng.uwo.ca [Department of Mechanical and Materials Engineering, University of Western Ontario, London, Ontario N6A 5B9 (Canada)

    2011-09-14

    This work investigates the electromechanical response of a curved piezoelectric nanobeam with the consideration of surface effects through the surface-layer-based model and the generalized Young-Laplace equations. For nanoscale piezoelectric structures, the surface effects also include surface piezoelectricity in addition to the residual surface stress and surface elasticity for elastic nanomaterials. A Euler-Bernoulli curved beam theory is used to get the explicit solutions for the electroelastic fields of a curved cantilever beam when subjected to mechanical and electrical loads. In order to apply the appropriate boundary conditions on the beam, effective axial force, shear force and moment are derived. The results indicate that the surface effects play a significant role in the electroelastic fields and the piezoelectric response of the curved piezoelectric nanobeam. It is also found that the coupling of the residual surface stress, the surface elasticity and the surface piezoelectricity may be dramatic despite that the influence of the individual one is small under some circumstances. This study is expected to be useful for design and applications of curved beam based piezoelectric nanodevices, such as the curved nanowires/nanobelts or nanorings as nanoswitches or nanoactuators for displacement control purpose.

  10. Characterizing transiting exoplanet atmospheres using NIRCam grism spectra

    Science.gov (United States)

    Greene, Thomas P.; Schlawin, Everett; Beichman, Charles A.; Line, Michael R.; Fortney, Jonathan J.; Fraine, Jonathan; JWST NIRCam Team

    2017-06-01

    JWST will enable high signal-to-noise spectroscopic observations of the atmospheres of transiting planets with high sensitivity at wavelengths that are inaccessible with HST or other existing facilities. We plan to exploit this by measuring abundances, chemical compositions, cloud properties, and temperature-pressure parameters of a set of mostly warm (T ~ 600 - 1200 K) and low mass (14 - 200 Earth mass) planets in our guaranteed time program. These planets are expected to have significant molecular absorptions of H2O, CH4, CO2, CO, and other molecules that are key for determining these parameters and illuminating how and where the planets formed. We describe how we will use the NIRCam grisms to observe slitless transmission and emission spectra of these planets over 2.4 - 5.0 microns wavelength and how well these observations can measure our desired parameters. This will include how we set integration times, exposure parameters, and obtain simultaneous shorter wavelength images to track telescope pointing and stellar variability. We will illustrate this with specific examples showing model spectra, simulated observations, expected information retrieval results, completed Astronomer's Proposal Tools observing templates, target visibility, and other considerations.

  11. A strategy to model nonmonotonic dose-response curve and estimate IC50.

    Science.gov (United States)

    Zhang, Hui; Holden-Wiltse, Jeanne; Wang, Jiong; Liang, Hua

    2013-01-01

    The half-maximal inhibitory concentration IC[Formula: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic sigmoidal models. However, recent studies on Human Immunodeficiency Virus (HIV) mutants developing resistance to antiviral drugs show that the dose response curve may not be monotonic. Traditional models can fail for nonmonotonic data and ignore observations that may be of biologic significance. Therefore, we propose a nonparametric model to describe the dose response relationship and fit the curve using local polynomial regression. The nonparametric approach is shown to be promising especially for estimating the IC[Formula: see text] of some HIV inhibitory drugs, in which there is a dose-dependent stimulation of response for mutant strains. This model strategy may be applicable to general pharmacologic, toxicologic, or other biomedical data that exhibits a nonmonotonic dose response relationship for which traditional parametric models fail.

  12. Eosinophils in the bronchial mucosa in relation to methacholine dose-response curves in atopic asthma

    NARCIS (Netherlands)

    G.M. Moller (Trude); S.E. Overbeek (Shelley); C.G. van Helden-Meeuwsen; H.C. Hoogsteden (Henk); J.M. Bogaard (Jan)

    1999-01-01

    textabstractAsthma is characterized by both local infiltration of eosinophils in the bronchial mucosa and bronchial hyperreactivity (BHR). A detailed characterization of BHR implies analysis of a histamine or methacholine dose-response curve yielding not only the dose a

  13. Mixed-effects Gaussian process functional regression models with application to dose-response curve prediction.

    Science.gov (United States)

    Shi, J Q; Wang, B; Will, E J; West, R M

    2012-11-20

    We propose a new semiparametric model for functional regression analysis, combining a parametric mixed-effects model with a nonparametric Gaussian process regression model, namely a mixed-effects Gaussian process functional regression model. The parametric component can provide explanatory information between the response and the covariates, whereas the nonparametric component can add nonlinearity. We can model the mean and covariance structures simultaneously, combining the information borrowed from other subjects with the information collected from each individual subject. We apply the model to dose-response curves that describe changes in the responses of subjects for differing levels of the dose of a drug or agent and have a wide application in many areas. We illustrate the method for the management of renal anaemia. An individual dose-response curve is improved when more information is included by this mechanism from the subject/patient over time, enabling a patient-specific treatment regime.

  14. A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC50

    OpenAIRE

    Hui Zhang; Jeanne Holden-Wiltse; Jiong Wang; Hua Liang

    2013-01-01

    The half-maximal inhibitory concentration IC[Formula: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic sigmoidal models. However, recent studies on Human Immunodeficiency Virus (HIV) mutants developing resistance to antiviral drugs show that the dose response curve may not be monotonic. Traditional models can fail for nonmonotonic data and igno...

  15. Dose-response curve to salbutamol during acute and chronic treatment with formoterol in COPD

    Directory of Open Access Journals (Sweden)

    La Piana GE

    2011-07-01

    Full Text Available Giuseppe Emanuele La Piana¹, Luciano Corda², Enrica Bertella¹, Luigi Taranto Montemurro¹, Laura Pini¹, Claudio Tantucci¹¹Cattedra di Malattie dell'Apparato Respiratorio, Università di Brescia, ²Prima Divisione di Medicina Interna, Spedali Civili, Brescia, ItalyBackground: Use of short-acting ß2-agonists in chronic obstructive pulmonary disease (COPD during treatment with long-acting ß2-agonists is recommended as needed, but its effectiveness is unclear. The purpose of this study was to assess the additional bronchodilating effect of increasing doses of salbutamol during acute and chronic treatment with formoterol in patients with COPD.Methods: Ten patients with COPD underwent a dose-response curve to salbutamol (until 800 µg of cumulative dose after a 1-week washout (baseline, 8 hours after the first administration of formoterol 12 µg (day 1, and after a 12-week and 24-week period of treatment with formoterol (12 µg twice daily by dry powder inhaler. Peak expiratory flow, forced expiratory volume in one second (FEV1, forced vital capacity, and inspiratory capacity were measured at the different periods of treatment and at different steps of the dose-response curve.Results: Despite acute or chronic administration of formoterol, maximal values of peak expiratory flow, FEV1, and forced vital capacity after 800 µg of salbutamol were unchanged compared with baseline. The baseline FEV1 dose-response curve was steeper than that at day 1, week 12, or week 24 (P < 0.0001. Within each dose-response curve, FEV1 was different only at baseline and at day 1 (P < 0.001, when FEV1 was still greater at 800 µg than at 0 µg (P < 0.02. In contrast, the forced vital capacity dose-response curves were similar at the different periods, while within each dose-response curve, forced vital capacity was different in all instances (P < 0.001, always being higher at 800 µg than at 0 µg (P < 0.05.Conclusion: In patients with stable COPD, the maximal effect

  16. Modeling and regression analysis of semiochemical dose-response curves of insect antennal reception and behavior.

    Science.gov (United States)

    Byers, John A

    2013-08-01

    Dose-response curves of the effects of semiochemicals on neurophysiology and behavior are reported in many articles in insect chemical ecology. Most curves are shown in figures representing points connected by straight lines, in which the x-axis has order of magnitude increases in dosage vs. responses on the y-axis. The lack of regression curves indicates that the nature of the dose-response relationship is not well understood. Thus, a computer model was developed to simulate a flux of various numbers of pheromone molecules (10(3) to 5 × 10(6)) passing by 10(4) receptors distributed among 10(6) positions along an insect antenna. Each receptor was depolarized by at least one strike by a molecule, and subsequent strikes had no additional effect. The simulations showed that with an increase in pheromone release rate, the antennal response would increase in a convex fashion and not in a logarithmic relation as suggested previously. Non-linear regression showed that a family of kinetic formation functions fit the simulated data nearly perfectly (R(2) >0.999). This is reasonable because olfactory receptors have proteins that bind to the pheromone molecule and are expected to exhibit enzyme kinetics. Over 90 dose-response relationships reported in the literature of electroantennographic and behavioral bioassays in the laboratory and field were analyzed by the logarithmic and kinetic formation functions. This analysis showed that in 95% of the cases, the kinetic functions explained the relationships better than the logarithmic (mean of about 20% better). The kinetic curves become sigmoid when graphed on a log scale on the x-axis. Dose-catch relationships in the field are similar to dose-EAR (effective attraction radius, in which a spherical radius indicates the trapping effect of a lure) and the circular EARc in two dimensions used in mass trapping models. The use of kinetic formation functions for dose-response curves of attractants, and kinetic decay curves for

  17. Dynamic Response and Optimal Design of Curved Metallic Sandwich Panels under Blast Loading

    Directory of Open Access Journals (Sweden)

    Chang Qi

    2014-01-01

    Full Text Available It is important to understand the effect of curvature on the blast response of curved structures so as to seek the optimal configurations of such structures with improved blast resistance. In this study, the dynamic response and protective performance of a type of curved metallic sandwich panel subjected to air blast loading were examined using LS-DYNA. The numerical methods were validated using experimental data in the literature. The curved panel consisted of an aluminum alloy outer face and a rolled homogeneous armour (RHA steel inner face in addition to a closed-cell aluminum foam core. The results showed that the configuration of a “soft” outer face and a “hard” inner face worked well for the curved sandwich panel against air blast loading in terms of maximum deflection (MaxD and energy absorption. The panel curvature was found to have a monotonic effect on the specific energy absorption (SEA and a nonmonotonic effect on the MaxD of the panel. Based on artificial neural network (ANN metamodels, multiobjective optimization designs of the panel were carried out. The optimization results revealed the trade-off relationships between the blast-resistant and the lightweight objectives and showed the great use of Pareto front in such design circumstances.

  18. Dynamic response and optimal design of curved metallic sandwich panels under blast loading.

    Science.gov (United States)

    Qi, Chang; Yang, Shu; Yang, Li-Jun; Han, Shou-Hong; Lu, Zhen-Hua

    2014-01-01

    It is important to understand the effect of curvature on the blast response of curved structures so as to seek the optimal configurations of such structures with improved blast resistance. In this study, the dynamic response and protective performance of a type of curved metallic sandwich panel subjected to air blast loading were examined using LS-DYNA. The numerical methods were validated using experimental data in the literature. The curved panel consisted of an aluminum alloy outer face and a rolled homogeneous armour (RHA) steel inner face in addition to a closed-cell aluminum foam core. The results showed that the configuration of a "soft" outer face and a "hard" inner face worked well for the curved sandwich panel against air blast loading in terms of maximum deflection (MaxD) and energy absorption. The panel curvature was found to have a monotonic effect on the specific energy absorption (SEA) and a nonmonotonic effect on the MaxD of the panel. Based on artificial neural network (ANN) metamodels, multiobjective optimization designs of the panel were carried out. The optimization results revealed the trade-off relationships between the blast-resistant and the lightweight objectives and showed the great use of Pareto front in such design circumstances.

  19. DOSE RESPONSE CURVE OF 60Co FOR PREMATURE CONDENSED CHROMOSOME FRAGMENTS OF HUMAN LYMPHOCYTES

    Institute of Scientific and Technical Information of China (English)

    高锦声; 郑斯英; 等

    1995-01-01

    The dose-response curves obtained by premature condensed chromosome(PCC) and conventional cellular genetic methods can be represented by two linear equations.The ratio of the slopes,KPCC/KM1,is about 28,In compartison to the conventional method.The PCC method has many advantages;e.g.it is faster,simopler,more sensitive and accurate.Its significance in the study of radiation damage is also discussed.

  20. Stimulus-response curve of human motor nerves: multicenter assessment of various indexes.

    Science.gov (United States)

    Boërio, D; Hogrel, J-Y; Lefaucheur, J-P; Wang, F C; Verschueren, A; Pouget, J; Carrera, E; Kuntzer, T

    2008-02-01

    The value of various indexes to characterize the stimulus-response curve of human motor nerves was assessed in 40 healthy subjects recruited from four European centers of investigation (Créteil, Lausanne, Liège, Marseille). Stimulus-response curves were established by stimulating the right median and ulnar motor nerves at the wrist, with stimulus durations of 0.05 and 0.5 ms. The following parameters were studied: the threshold intensity of stimulation to obtain 10% (I 10), 50% (I 50), and 90% (I 90) of the maximal compound muscle action potential, the ratios I 10/I 50, I 90/I 50, (I 90 - I 10)/I 10, (I 90-I 50)/I 50, and (I 50 - I 10)/I 10, and the slopes of the stimulus-response curves with or without normalization to I 50. For each parameter, within-center variability and reproducibility (in a test-retest study) were assessed and between-center comparisons were made. For most of the parameters, the results varied significantly within and between the centers. Within the centers, only the ratios I 10/I 50 and I 90/I 50 were found constant and reproducible. Between the centers, the absolute intensity thresholds (I 10, I 50, I 90) and the ratio I 90/I 50 did not show significant differences at stimulus duration of 0.5 ms, whatever the stimulated nerve. The reduced variability and good reproducibility of the ratios I 10/I 50 and I 90/I 50 open perspectives in neurophysiological practice for the use of these indexes of the stimulus-response curve, a rapid and noninvasive test.

  1. Bayesian fitting of a logistic dose-response curve with numerically derived priors.

    Science.gov (United States)

    Huson, L W; Kinnersley, N

    2009-01-01

    In this report we describe the Bayesian analysis of a logistic dose-response curve in a Phase I study, and we present two simple and intuitive numerical approaches to construction of prior probability distributions for the model parameters. We combine these priors with the expert prior opinion and compare the results of the analyses with those obtained from the use of alternative prior formulations.

  2. Environmental standards for ionizing radiation: theoretical basis for dose-response curves.

    Science.gov (United States)

    Upton, A C

    1983-10-01

    The types of injury attributable to ionizing radiation are subdivided, for purposes of risk assessment and radiological protection, into two broad categories: stochastic effects and nonstochastic effects. Stochastic effects are viewed as probablistic phenomena, varying in frequency but not severity as a function of the dose, without any threshold; nonstochastic effects are viewed as deterministic phenomena, varying in both frequency and severity as a function of the dose, with clinical thresholds. Included among stochastic effects are heritable effects (mutations and chromosome aberrations) and carcinogenic effects. Both types of effects are envisioned as unicellular phenomena which can result from nonlethal injury of individual cells, without the necessity of damage to other cells. For the induction of mutations and chromosome aberrations in the low-to-intermediate dose range, the dose-response curve with high-linear energy transfer (LET) radiation generally conforms to a linear nonthreshold relationship and varies relatively little with the dose rate. In contrast, the curve with low-LET radiation generally conforms to a linear-quadratic relationship, rising less steeply than the curve with high-LET radiation and increasing in slope with increasing dose and dose rate. The dose-response curve for carcinogenic effects varies widely from one type of neoplasm to another in the intermediate-to-high dose range, in part because of differences in the way large doses of radiation can affect the promotion and progression of different neoplasms. Information about dose-response relations for low-level irradiation is fragmentary but consistent, in general, with the hypothesis that the neoplastic transformation may result from mutation, chromosome aberration or genetic recombination in a single susceptible cell.

  3. A WFC3 Grism Emission Line Redshift Catalog in the GOODS-South Field

    CERN Document Server

    Morris, Aaron M; Trump, Jonathan R; Weiner, Benjamin J; Hathi, Nimish P; Barro, Guillermo; Dahlen, Tomas; Faber, Sandra M; Finkelstein, Steven L; Fontana, Adriano; Ferguson, Henry C; Grogin, Norman A; Grützbauch, Ruth; Guo, Yicheng; Hsu, Li-Ting; Koekemoer, Anton M; Koo, David C; Mobasher, Bahram; Pforr, Janine; Salvato, Mara; Wiklind, Tommy; Wuyts, Stijn

    2015-01-01

    We combine HST/WFC3 imaging and G141 grism observations from the CANDELS and 3D-HST surveys to produce a catalog of grism spectroscopic redshifts for galaxies in the CANDELS/GOODS-South field. The WFC3/G141 grism spectra cover a wavelength range of 1.1 0.6. The resulting spectra are visually inspected to identify emission lines and redshifts are determined using cross-correlation with empirical spectral templates. To establish the accuracy of our redshifts, we compare our results against high-quality spectroscopic redshifts from the literature. Using a sample of 411 control galaxies, this analysis yields a precision of sigma_NMAD=0.0028 for the grism-derived redshifts, which is consistent with the accuracy reported by the 3D-HST team. Our final catalog covers an area of 153 square arcmin and contains 1019 redshifts for galaxies in GOODS-S. Roughly 60% (608/1019) of these redshifts are for galaxies with no previously published spectroscopic redshift. These new redshifts span a range of 0.677 1.5. In addition, ...

  4. Quantitative aspects of informed consent: considering the dose response curve when estimating quantity of information.

    Science.gov (United States)

    Lynöe, N; Hoeyer, K

    2005-12-01

    Information is usually supposed to be a prerequisite for people making decisions on whether or not to participate in a clinical trial. Previously conducted studies and research ethics scandals indicate that participants have sometimes lacked important pieces of information. Over the past few decades the quantity of information believed to be adequate has increased significantly, and in some instances a new maxim seems to be in place: the more information, the better the ethics in terms of respecting a participant's autonomy. The authors hypothesise that the dose-response curve from pharmacology or toxicology serves as a model to illustrate that a large amount of written information does not equal optimality. Using the curve as a pedagogical analogy when teaching ethics to students in clinical sciences, and also in engaging in dialogue with research institutions, may promote reflection on how to adjust information in relation to the preferences of individual participants, thereby transgressing the maxim that more information means better ethics.

  5. Analyzing Multiple-Choice Questions by Model Analysis and Item Response Curves

    Science.gov (United States)

    Wattanakasiwich, P.; Ananta, S.

    2010-07-01

    In physics education research, the main goal is to improve physics teaching so that most students understand physics conceptually and be able to apply concepts in solving problems. Therefore many multiple-choice instruments were developed to probe students' conceptual understanding in various topics. Two techniques including model analysis and item response curves were used to analyze students' responses from Force and Motion Conceptual Evaluation (FMCE). For this study FMCE data from more than 1000 students at Chiang Mai University were collected over the past three years. With model analysis, we can obtain students' alternative knowledge and the probabilities for students to use such knowledge in a range of equivalent contexts. The model analysis consists of two algorithms—concentration factor and model estimation. This paper only presents results from using the model estimation algorithm to obtain a model plot. The plot helps to identify a class model state whether it is in the misconception region or not. Item response curve (IRC) derived from item response theory is a plot between percentages of students selecting a particular choice versus their total score. Pros and cons of both techniques are compared and discussed.

  6. Study of the Composition and Spectral Characteristics of a HDG-Prism Disperse System (GRISM) by Refractive Index Phase Matching

    CERN Document Server

    Jo, Chon-Gyu; Im, Song-Jin

    2015-01-01

    The composition and characteristics of a GRISM gained by refractive index matching between a refractive index modulation type HDG and a prism is investigated, the HDG being built by processing silver halide emulsion with halide vapor. The GRISM has been stable under external influences like humidity or ultraviolet light exposure. The mercury atomic spectrum obtained by a GRISM based on a HDG with a spatial frequency of 600mm-1 shows yellow dual lines with the wavelength difference of 2.1nm sufficiently separated.

  7. Mathematical modeling improves EC50 estimations from classical dose-response curves.

    Science.gov (United States)

    Nyman, Elin; Lindgren, Isa; Lövfors, William; Lundengård, Karin; Cervin, Ida; Sjöström, Theresia Arbring; Altimiras, Jordi; Cedersund, Gunnar

    2015-03-01

    The β-adrenergic response is impaired in failing hearts. When studying β-adrenergic function in vitro, the half-maximal effective concentration (EC50 ) is an important measure of ligand response. We previously measured the in vitro contraction force response of chicken heart tissue to increasing concentrations of adrenaline, and observed a decreasing response at high concentrations. The classical interpretation of such data is to assume a maximal response before the decrease, and to fit a sigmoid curve to the remaining data to determine EC50 . Instead, we have applied a mathematical modeling approach to interpret the full dose-response curve in a new way. The developed model predicts a non-steady-state caused by a short resting time between increased concentrations of agonist, which affect the dose-response characterization. Therefore, an improved estimate of EC50 may be calculated using steady-state simulations of the model. The model-based estimation of EC50 is further refined using additional time-resolved data to decrease the uncertainty of the prediction. The resulting model-based EC50 (180-525 nm) is higher than the classically interpreted EC50 (46-191 nm). Mathematical modeling thus makes it possible to re-interpret previously obtained datasets, and to make accurate estimates of EC50 even when steady-state measurements are not experimentally feasible. The mathematical models described here have been submitted to the JWS Online Cellular Systems Modelling Database, and may be accessed at http://jjj.bio.vu.nl/database/nyman. © 2015 FEBS.

  8. Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay.

    Science.gov (United States)

    Cornaglia, Matteo; Trouillon, Raphaël; Tekin, H Cumhur; Lehnert, Thomas; Gijs, Martin A M

    2015-09-25

    Magnetic micro- and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quantification of a sample's analyte concentration have been among the most sensitive and have allowed protein detection lower than the fgmL(-1) concentration range. Recently, we have proposed in this category a magnetic bead surface coverage assay (Tekin et al., 2013 [1]), in which 'large' (2.8μm) antibody (Ab)-functionalized magnetic beads captured their Ag from a serum and these Ag-carrying beads were subsequently exposed to a surface pattern of fixed 'small' (1.0μm) Ab-coated magnetic beads. When the system was exposed to a magnetic induction field, the magnet dipole attractive interactions between the two bead types were used as a handle to approach both bead surfaces and assist with Ag-Ab immunocomplex formation, while unspecific binding (in absence of an Ag) of a large bead was reduced by exploiting viscous drag flow. The dose-response curve of this type of assay had two remarkable features: (i) its ability to detect an output signal (i.e. bead number count) for very low Ag concentrations, and (ii) an output signal of the assay that was non-linear with respect to Ag concentration. We explain here the observed dose-response curves and show that the type of interactions and the concept of our assay are in favour of detecting the lowest analyte concentrations (where typically either zero or one Ag is carried per large bead), while higher concentrations are less efficiently detected. We propose a random walk process for the Ag-carrying bead over the magnetic landscape of small beads and this model description explains the enhanced overall capture probability of this assay and its particular non-linear dose response curves.

  9. Quantitative structure-activity relationships of selected phenols with non-monotonic dose-response curves

    Institute of Scientific and Technical Information of China (English)

    GAO ChangAn; ZHANG AiQian; LIN Yuan; YIN DaQiang; WANG LianSheng

    2009-01-01

    Particular non-monotonic dose-response curves of many endocrine disrupting chemicals (EDCs) suggest the existence of diverse toxicity mechanisms at different dose levels. As a result, the biologi-cal activities of EDCs cannot be simply exhibited by unique EC/LD<,50. values, and the quantitative structure-activity relationship (QSAR) analysis for non-monotonic dose-response relationship be-comes an unknown field in the environmental science. In this paper, nine phenols with inverted U-shaped dose-response curves in lymphocyte proliferation test of Carassius auratus were selected. The binding interactions between the phenols and several typical EDCs-related receptors were then explored in a molecular simulation study. The estrogen receptor (ER), androgen receptor (AR), thyroid hormone receptor (TR), bacterial O2 sensing FixL protein (FixL), aryl hydrocarbon receptor (AhR), and the peroxisome proliferator-activated receptor (PPAR) were the target receptors in the study. Linear regression QSAR models for the low and high exposure levels of the compounds were developed separately. The results indicated that the lymphocyte proliferation in the low-dose range might involve ER-mediated process, while the proliferation inhibition in the high dose range was dominated by the acute toxicity of phenols due to receptor occupancy and cell damage.

  10. Phase resetting for a network of oscillators via phase response curve approach.

    Science.gov (United States)

    Efimov, D

    2015-02-01

    The problem of phase regulation for a population of oscillating systems is considered. The proposed control strategy is based on a phase response curve (PRC) model of an oscillator (the first-order reduced model obtained for linearized system and inputs with infinitesimal amplitude). It is proven that the control provides phase resetting for the original nonlinear system. Next, the problem of phase resetting for a network of oscillators is considered when applying a common control input. Performance of the obtained solutions is demonstrated via computer simulation for three different models of circadian/neural oscillators.

  11. Construction and validation of a dose-response curve using the comet assay to determine human radiosensitivity to ionizing radiation.

    Science.gov (United States)

    Güerci, A; Zúñiga, L; Marcos, R

    2011-01-01

    Individual radiosensitivity is an individual characteristic associated with an increased reaction to ionizing radiation. The purpose of our work is to establish a dose-response curve useful to classify individuals as radiosensitive or radioresistant. Thus, a dose-response curve was constructed by measuring in vitro responses to increasing doses (0 to 8 Gy) of gamma radiation in the comet assay. The obtained curve fit well with a linear equation in the range of 0 to 8 Gy. The overall dose-response curve was constructed for percent DNA in tail, as a measure of the genetic damage induced by irradiation. To probe the goodness of the constructed curve, a validation study was carried out with whole blood from two donors in a blind study. Results show that, for the two applied doses (2 and 6 Gy), the obtained values fit well inside the interval of confidence of the curve. In conclusion, our results demonstrate the usefulness of the comet assay in determining individual responses to defined doses of gamma radiation. The standard dose-response curve constructed may be used to detect individuals departing from reference values.

  12. Principal response curves: analysis of time-dependent multivariate responses of biological community to stress

    NARCIS (Netherlands)

    Brink, van den P.J.; Braak, ter C.J.F.

    1999-01-01

    In this paper a novel multivariate method is proposed for the analysis of community response data from designed experiments repeatedly sampled in time. The long-term effects of the insecticide chlorpyrifos on the invertebrate community and the dissolved oxygen (DO)–pH–alkalinity–conductivity syndrom

  13. Response to Martini and Habeck: Semiochemical dose-response curves fit by kinetic formation functions

    Science.gov (United States)

    Martini and Habeck (2014) correctly describe the conceptual simulation model of Byers (2013) where molecules in an odor filament pass by an antenna causing an electrophysiological antennographic (EAG) response that is proportional to how many of the receptors are hit at least once by a molecule. Inc...

  14. Melatonin entrains free-running blind people according to a physiological dose-response curve.

    Science.gov (United States)

    Lewy, Alfred J; Emens, Jonathan S; Lefler, Bryan J; Yuhas, Krista; Jackman, Angela R

    2005-01-01

    The specific circadian role proposed for endogenous melatonin production was based on a study of sighted people who took low pharmacological doses (500 microg) of this chemical signal for the "biological night": the magnitude and direction of the induced phase shifts were dependent on what time of day exogenous melatonin was administered and were described by a phase-response curve that turned out to be the opposite of that for light. We now report that lower (physiological) doses of up to 300 microg can entrain (synchronize) free-running circadian rhythms of 10 totally blind subjects that would otherwise drift later each day. The resulting log-linear dose-response curve in the physiological range adds support for a circadian function of endogenous melatonin in humans. Efficacy of exogenous doses in the physiological range are of clinical significance for totally blind people who will need to take melatonin daily over their entire lifetimes in order to remain entrained to the 24 h day. Left untreated, their free-running endocrine, metabolic, behavioral, and sleep/wake cycles can be almost as burdensome as not having vision.

  15. Linearization of dose-response curve of the radiochromic film dosimetry system

    Energy Technology Data Exchange (ETDEWEB)

    Devic, Slobodan; Tomic, Nada; Aldelaijan, Saad; DeBlois, Francois; Seuntjens, Jan; Chan, Maria F.; Lewis, Dave [Medical Physics Unit, McGill University, Montreal, Quebec H3G 1A4 (Canada) and Department of Radiation Oncology, SMBD Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2 (Canada); Executive Administration for Radiation Protection and Safety Medical Devices Sector, Saudi Food and Drug Authority, Riyadh, Kingdom of Saudi Arabia 13312 (Saudi Arabia); Medical Physics Unit, McGill University, Montreal, Quebec H3G 1A4 (Canada) and Department of Radiation Oncology, SMBD Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2 (Canada); Medical Physics Unit, McGill University, Montreal, Quebec H3G 1A4 (Canada); Department of Medical Physics, Memorial Sloan-Kettering Cancer Center Basking Ridge, New Jersey 07920 (United States); Ashland Inc., Wayne, New Jersey 07470 (United States)

    2012-08-15

    Purpose: Despite numerous advantages of radiochromic film dosimeter (high spatial resolution, near tissue equivalence, low energy dependence) to measure a relative dose distribution with film, one needs to first measure an absolute dose (following previously established reference dosimetry protocol) and then convert measured absolute dose values into relative doses. In this work, we present result of our efforts to obtain a functional form that would linearize the inherently nonlinear dose-response curve of the radiochromic film dosimetry system. Methods: Functional form [{zeta}= (-1){center_dot}netOD{sup (2/3)}/ln(netOD)] was derived from calibration curves of various previously established radiochromic film dosimetry systems. In order to test the invariance of the proposed functional form with respect to the film model used we tested it with three different GAFCHROMIC Trade-Mark-Sign film models (EBT, EBT2, and EBT3) irradiated to various doses and scanned on a same scanner. For one of the film models (EBT2), we tested the invariance of the functional form to the scanner model used by scanning irradiated film pieces with three different flatbed scanner models (Epson V700, 1680, and 10000XL). To test our hypothesis that the proposed functional argument linearizes the response of the radiochromic film dosimetry system, verification tests have been performed in clinical applications: percent depth dose measurements, IMRT quality assurance (QA), and brachytherapy QA. Results: Obtained R{sup 2} values indicate that the choice of the functional form of the new argument appropriately linearizes the dose response of the radiochromic film dosimetry system we used. The linear behavior was insensitive to both film model and flatbed scanner model used. Measured PDD values using the green channel response of the GAFCHROMIC Trade-Mark-Sign EBT3 film model are well within {+-}2% window of the local relative dose value when compared to the tabulated Cobalt-60 data. It was also

  16. A Theoretical Model for the Hormetic Dose-response Curve for Anticancer Agents.

    Science.gov (United States)

    Yoshimasu, Tatsuya; Ohashi, Takuya; Oura, Shoji; Kokawa, Yozo; Kawago, Mitsumasa; Hirai, Yoshimitsu; Miyasaka, Miwako; Nishiguchi, Haruka; Kawashima, Sayoko; Yata, Yumi; Honda, Mariko; Fujimoto, Takahiro; Okamura, Yoshitaka

    2015-11-01

    In the present article, we quantitatively evaluated the dose-response relationship of hormetic reactions of anticancer agents in vitro. Serial dilutions of gemcitabine, cisplatin, 5-fluorouracil, vinorelbine, and paclitaxel were administered to the A549 non-small-cell lung cancer cell line. The bi-phasic sigmoidal curve with hormetic and cytotoxic effects is given by the formula y=(a-b/(1+exp(c(*)log(x)-d)))/(1+exp(e(*)log(x)-f)), that was used to perform a non-linear least square regression. The dose-responses of the five anticancer agents were fitted to this equation. Gemcitabine and 5-fluorouracil, which had the lowest ED50 for their hormetic reaction, had the most pronounced promotive effects out of the five anticancer agents tested. The hormetic reaction progressed exponentially with culturing time. Our theoretical model will be useful in predicting how hormetic reactions affect patients with malignant tumors.

  17. A method for inverse bifurcation of biochemical switches: inferring parameters from dose response curves.

    Science.gov (United States)

    Otero-Muras, Irene; Yordanov, Pencho; Stelling, Joerg

    2014-11-20

    Within cells, stimuli are transduced into cell responses by complex networks of biochemical reactions. In many cell decision processes the underlying networks behave as bistable switches, converting graded stimuli or inputs into all or none cell responses. Observing how systems respond to different perturbations, insight can be gained into the underlying molecular mechanisms by developing mathematical models. Emergent properties of systems, like bistability, can be exploited to this purpose. One of the main challenges in modeling intracellular processes, from signaling pathways to gene regulatory networks, is to deal with high structural and parametric uncertainty, due to the complexity of the systems and the difficulty to obtain experimental measurements. Formal methods that exploit structural properties of networks for parameter estimation can help to overcome these problems. We here propose a novel method to infer the kinetic parameters of bistable biochemical network models. Bistable systems typically show hysteretic dose response curves, in which the so called bifurcation points can be located experimentally. We exploit the fact that, at the bifurcation points, a condition for multistationarity derived in the context of the Chemical Reaction Network Theory must be fulfilled. Chemical Reaction Network Theory has attracted attention from the (systems) biology community since it connects the structure of biochemical reaction networks to qualitative properties of the corresponding model of ordinary differential equations. The inverse bifurcation method developed here allows determining the parameters that produce the expected behavior of the dose response curves and, in particular, the observed location of the bifurcation points given by experimental data. Our inverse bifurcation method exploits inherent structural properties of bistable switches in order to estimate kinetic parameters of bistable biochemical networks, opening a promising route for developments in

  18. Influence of lung parenchymal destruction on the different indexes of the methacholine dose-response curve in COPD patients

    NARCIS (Netherlands)

    G.T. Verhoeven; A.F.M. Verbraak (Anton); S. Boere-van der Straat; H.C. Hoogsteden (Henk); J.M. Bogaard (Jan)

    2000-01-01

    textabstractSTUDY OBJECTIVES: The interpretation of nonspecific bronchial provocation dose-response curves in COPD is still a matter of debate. Bronchial hyperresponsiveness (BHR) in patients with COPD could be influenced by the destruction of the parenchyma and the

  19. Investigating quartz optically stimulated luminescence dose-response curves at high doses

    Energy Technology Data Exchange (ETDEWEB)

    Lowick, Sally E., E-mail: lowick@geo.unibe.c [Institut fuer Geologie, Universitaet Bern, Baltzerstrasse 1-3, 3012 Bern (Switzerland); Preusser, Frank [Institut fuer Geologie, Universitaet Bern, Baltzerstrasse 1-3, 3012 Bern (Switzerland); Wintle, Ann G. [Institute of Geography and Earth Sciences, Aberystwyth University, AberystwythSY23 3DB (United Kingdom)

    2010-10-15

    Despite the general expectation that optically stimulated luminescence (OSL) growth should be described by a simple saturating exponential function, an additional high dose component is often reported in the dose response of quartz. Although often reported as linear, it appears that this response is the early expression of a second saturating exponential. While some studies using equivalent doses that fall in this high dose region have produced ages that correlate well with independent dating, others report that it results in unreliable age determinations. Two fine grain sedimentary quartz samples that display such a response were used to investigate the origin of this additional high dose component: three experiments were conducted to examine their dose-response up to >1000 Gy. The high dose rates provided by laboratory irradiation were found not to induce a sensitivity change in the response to a subsequent test dose, with the latter not being significantly different from those generated following naturally acquired doses. The relative percentage contributions of the fast and medium OSL components remained fixed throughout the dose-response curve, suggesting that the electron traps that give rise to the initial OSL do not change with dose. An attempt was made to investigate a change in luminescence centre recombination probability by monitoring the depletion of the '325 {sup o}C' thermoluminescence (TL) during the optical stimulation that would result in depletion of the OSL signal. The emissions measured through both the conventional ultraviolet (UV), and a longer wavelength violet/blue (VB) window, displayed similar relative growth with dose, although it was not possible to resolve the origin of the VB emissions. No evidence was found to indicate whether the additional component at high doses occurs naturally or is a product of laboratory treatment. However, it appears that these samples display an increased sensitivity of quartz OSL to high doses

  20. Flux Calibration Monitoring: WFC3/IR G102 and G141 Grisms

    Science.gov (United States)

    Lee, Janice C.; Pirzkal, Norbert; Hilbert, Bryan

    2014-01-01

    As part of the regular WFC3 flux calibration mo nitoring program, we analyze WFC3/IR G102 and G141 grism observations of the standard star GD153 taken in 2013June (Cycle 20 P rogram 13092). The IR grism flux calibrations for the +1 order spectra are shown to have excellent temporal stability over WFC3's 4 years of operation, with average variations constr ained to be less than 1%. Tests of the current corrections for throughput variations over the field - of - view and aperture losses are also performed, and no significant changes are found. These results confirm that the G102 and G141 sensitivity functions and flat - field cubes currently in use for +1 order spectra are still valid.

  1. Wayne—A Simulator for HST  WFC3 IR Grism Spectroscopy

    Science.gov (United States)

    Varley, R.; Tsiaras, A.; Karpouzas, K.

    2017-07-01

    Wayne is an algorithm that simulates Hubble Space Telescope Wide Field Camera 3 (WFC3) grism spectroscopic frames, including sources of noise and systematics. It can simulate both staring and spatial scan modes, and observations such as the transit and the eclipse of an exoplanet. Unlike many other instrument simulators, the focus of Wayne is on creating frames with realistic systematics in order to test the effectiveness of different data analysis methods in a variety of different scenarios. This approach is critical for method validation and optimizing observing strategies. In this paper we describe the implementation of Wayne for WFC3 in the near-infrared channel with the G102 and G141 grisms. We compare the simulations to real data obtained for the exoplanet HD 209458b, to verify the accuracy of the simulation. The software is now available as open source at https://github.com/ucl-exoplanets/wayne.

  2. POD curves for non-maximizable ultrasonic responses: Statistical derivation and application to solid freight axles

    Science.gov (United States)

    Carboni, Michele; Cantini, Stefano

    2016-02-01

    The most relevant standards on ultrasonic testing, and an effective inspection practice, require the maximization of echo responses due to indications before their evaluation in terms of amplitude and size. This is achieved effectively pointing the acoustic axis of the sound beam to the indication, in a way to get back the maximum possible sound energy. Considering some operative cases, however, such a response maximization is not always feasible, mainly due to geometrical constraints impeding the inspection of the whole control area with a constant sensitivity. The traditional end inspection of solid railway axles by a rotating probe mounting conventional sensors falls back into this kind of inspections. In particular, inspection angles are fixed and the probe holder cannot move along the axle allowing response maximization of in-service damages located, for example, along the cylindrical body. It follows some control areas cannot be inspected using the maximum sound pressure. The present research shows how the derivation of "Probability of Detection" curves for non-maximizable ultrasonic responses cannot be carried out by the traditional statistical approach and a novel one, of the "Model-Assisted Probability of Detection" kind, is consequently proposed based on experiments and numerical simulations.

  3. A Remarkably Luminous Galaxy at z=11.1 Measured with Hubble Space Telescope Grism Spectroscopy

    CERN Document Server

    Oesch, P A; van Dokkum, P G; Illingworth, G D; Bouwens, R J; Labbe, I; Franx, M; Momcheva, I; Ashby, M L N; Fazio, G G; Gonzalez, V; Holden, B; Magee, D; Skelton, R E; Smit, R; Spitler, L R; Trenti, M; Willner, S P

    2016-01-01

    We present Hubble WFC3/IR slitless grism spectra of a remarkably bright $z\\gtrsim10$ galaxy candidate, GN-z11, identified initially from CANDELS/GOODS-N imaging data. A significant spectroscopic continuum break is detected at $\\lambda=1.47\\pm0.01~\\mu$m. The new grism data, combined with the photometric data, rule out all plausible lower redshift solutions for this source. The only viable solution is that this continuum break is the Ly$\\alpha$ break redshifted to ${z_\\mathrm{grism}=11.09^{+0.08}_{-0.12}}$, just $\\sim$400 Myr after the Big Bang. This observation extends the current spectroscopic frontier by 150 Myr to well before the Planck (instantaneous) cosmic reionization peak at z~8.8, demonstrating that galaxy build-up was well underway early in the reionization epoch at z>10. GN-z11 is remarkably and unexpectedly luminous for a galaxy at such an early time: its UV luminosity is 3x larger than L* measured at z~6-8. The Spitzer IRAC detections up to 4.5 $\\mu$m of this galaxy are consistent with a stellar m...

  4. First Results from Contamination Monitoring with the WFC3 UVIS G280 Grism

    Science.gov (United States)

    Rothberg, B.; Pirzkal, N.; Baggett, S.

    2011-11-01

    The presence of contaminants within the optical light path of the instrument or telescope can alter photometric zeropoints and the observed flux levels of imaging and spectra, particularly at UV wavelengths. Regular monitoring of a spectro-photometric standard star using photometric filters has been used in the past to monitor the presence of contaminants and (when necessary) re-calibrate zeropoints. However, the use of the WFC3 UVIS Grism mode (G280 filter) may provide a more robust early alert detection system for the presence of contaminants, in particular, those that are photo-polymerized from the bright Earth. These contaminants may collect on surfaces in the optical light path of the telescope. The G280 grism is sensitive to light at wavelengths below the cutoff of the bluest UV filter (F218W). In this ISR, we present: 1) the first results from G280 monitoring for the period of 2010-November through 2011-August; 2) the discovery of an anomaly in the WCS header information of sub-array exposures; and 3) an outline for reducing standard G280 grism observations and the specialized case of observations obtained in sub-array mode.

  5. Swift UVOT Grism Spectroscopy of Comets: A First Application to C/2007 N3 (Lulin)

    CERN Document Server

    Bodewits, D; Mumma, M J; Landsman, W B; Carter, J A; Read, A M

    2010-01-01

    We observed comet C/2007 N3 (Lulin) twice on UT 28 January 2009, using the UV grism of the Ultraviolet and Optical Telescope (UVOT) on board the Swift Gamma Ray Burst space observatory. Grism spectroscopy provides spatially resolved spectroscopy over large apertures for faint objects. We developed a novel methodology to analyze grism observations of comets, and applied a Haser comet model to extract production rates of OH, CS, NH, CN, C3, C2, and dust. The water production rates retrieved from two visits on this date were $6.7 \\pm 0.7$ and 7.9 $\\pm$ 0.7 x 1E28 molecules s-1, respectively. Jets were sought (but not found) in the white-light and ‘OH’ images reported here, suggesting that the jets reported by Knight and Schleicher (2009) are unique to CN. Based on the abundances of its carbon-bearing species, comet Lulin is ‘typical’ (i.e., not ‘depleted’) in its composition.

  6. The Grism Lens-Amplified Survey from Space (GLASS). I. Survey overview and first data release

    CERN Document Server

    Treu, T; Brammer, G B; Vulcani, B; Wang, X; Bradač, M; Dijkstra, M; Dressler, A; Fontana, A; Gavazzi, R; Henry, A L; Hoag, A; Huang, K H; Jones, T A; Kelly, P L; Malkan, M A; Mason, C; Pentericci, L; Poggianti, B; Stiavelli, M; Trenti, M; von der Linden, A

    2015-01-01

    We give an overview of the Grism Lens Amplified Survey from Space (GLASS), a large Hubble Space Telescope program aimed at obtaining grism spectroscopy of the fields of ten massive clusters of galaxies at redshift z=0.308-0.686, including the Hubble Frontier Fields (HFF). The Wide Field Camera 3 yields near infrared spectra of the cluster cores, covering the wavelength range 0.81-1.69mum through grisms G102 and G141, while the Advanced Camera for Surveys in parallel mode provides G800L spectra of the infall regions of the clusters. The WFC3 spectra are taken at two almost orthogonal position angles in order to minimize the effects of confusion. After summarizing the scientific drivers of GLASS, we describe the sample selection as well as the observing strategy and data processing pipeline. We then utilize MACSJ0717.5+3745, a HFF cluster and the first one observed by GLASS, to illustrate the data quality and the high-level data products. Each spectrum brighter than H_AB=23 is visually inspected by at least two...

  7. Can we predict ectotherm responses to climate change using thermal performance curves and body temperatures?

    DEFF Research Database (Denmark)

    Sinclair, Brent J.; Marshall, Katie E.; Sewell, Mary A.;

    2016-01-01

    Thermal performance curves (TPCs), which quantify how an ectotherm's body temperature (T-b) affects its performance or fitness, are often used in an attempt to predict organismal responses to climate change. Here, we examine the key - but often biologically unreasonable - assumptions underlying...... this approach; for example, that physiology and thermal regimes are invariant over ontogeny, space and time, and also that TPCs are independent of previously experienced T-b. We show how a critical consideration of these assumptions can lead to biologically useful hypotheses and experimental designs....... For example, rather than assuming that TPCs are fixed during ontogeny, one can measure TPCs for each major life stage and incorporate these into stage-specific ecological models to reveal the life stage most likely to be vulnerable to climate change. Our overall goal is to explicitly examine the assumptions...

  8. Clinical application of Chamomilla recutita in phlebitis: dose response curve study.

    Science.gov (United States)

    Reis, Paula Elaine Diniz Dos; Carvalho, Emilia Campos de; Bueno, Paula Carolina Pires; Bastos, Jairo Kenupp

    2011-01-01

    This experimental and dose-response curve study aimed to carry out the quality control of the Chamomilla recutita sample, as well as to estimate the ideal dose, for anti-inflammatory effect, of the extract of its capitula, in patients with phlebitis due to peripheral intravenous infusion of antineoplastic chemotherapy and to evaluate the toxicity of this extract in human beings. The therapeutic efficacy, concerning the anti-inflammatory potential, of different doses of Chamomilla recutita extract were analyzed and compared in 25 patients. The time of regression of phlebitis was shorter for groups with 2.5% concentration (mean=29.2h, standard deviation = 8.98) and 5% concentration (mean = 38.8h, standard deviation = 17.47). Local toxicity was almost not observed. This research contributes to the innovation of the nursing clinical practice, since it suggests an alternative for the treatment of phlebitis through the clinical use of phytotherapeutic drugs.

  9. Therapeutic efficacy of endostatin exhibits a biphasic dose-response curve.

    Science.gov (United States)

    Celik, Ilhan; Sürücü, Oguzkan; Dietz, Carsten; Heymach, John V; Force, Jeremy; Höschele, Iris; Becker, Christian M; Folkman, Judah; Kisker, Oliver

    2005-12-01

    We show here that recombinant endostatin protein has a biphasic effect on the inhibition of endothelial cell migration in vitro. In tumor-bearing animals, there is a similar biphasic effect on the inhibition of tumor growth and on circulating endothelial cells after once-daily s.c. injections. This biphasic effect is revealed as a U-shaped curve in which efficacy is optimal between very low and very high doses depending on the tumor type. This result may be applicable to other inhibitors of endothelial growth and to angiogenesis. Furthermore, these results have important implications for clinicians who administer angiogenesis inhibitors for cancer or other angiogenesis-dependent diseases. When these results are taken together with two previous reports of angiogenesis inhibitors with a U-shaped dose-response, they suggest that other regulators of endothelial growth may display a similar pattern.

  10. Effect of intrinsic motivation on affective responses during and after exercise: latent curve model analysis.

    Science.gov (United States)

    Shin, Myoungjin; Kim, Inwoo; Kwon, Sungho

    2014-12-01

    Understanding the relationship between affect and exercise is helpful in predicting human behavior with respect to exercise participation. The goals of the present study were to investigate individual differences in affective response during and after exercise and to identify the role of intrinsic motivation in affective changes. 30 active male college students (M age = 21.4 yr.) who regularly participated in sports activities volunteered to answer a questionnaire measuring intrinsic motivation toward running activities and performed a 20-min. straight running protocol at heavy intensity (about 70% of VO2max). Participants' affective responses were measured every 5 min. from the beginning of the run to 10 min. after completing the run. Latent curve model analysis indicated that individuals experienced different changes in affective state during exercise, moderated by intrinsic motivation. Higher intrinsic motivation was associated with more positive affect during exercise. There were no significant individual differences in the positive tendency of the participants' affective responses after exercise over time. Intrinsic motivation seems to facilitate positive feelings during exercise and encourages participation in exercise.

  11. Quality control procedures for dose-response curve generation using nanoliter dispense technologies.

    Science.gov (United States)

    Quintero, Catherine; Rosenstein, Craig; Hughes, Bethany; Middleton, Richard; Kariv, Ilona

    2007-09-01

    With the advancement of high-throughput biomolecular screening techniques to the lead optimization stage, there is a critical need to quality control (QC) dose-response curves generated by robotic liquid handlers to ensure accurate affinity determinations. One challenge in evaluating the performance of liquid handlers is identifying and validating a robust method for testing dispense volumes across different instruments. Although traditional automated liquid handlers are still considered the standard platform in many laboratories, nanoliter dispensers are becoming more common and pose new challenges for routine quality control procedures. For example, standard gravimetric measurements are unreliable for testing the accuracy of nanoliter liquid dispenses. However, nanoliter dispensing technology allows for the conservation of compound, reduces compound carryover from well to well through discrete dispenses, and eliminates the need for intermediate compound dilution steps to achieve a low final DMSO assay concentration. Moreover, an intermediate dilution step in aqueous solution might result in compound precipitation at high concentrations. This study compared representative automation procedures done on a variety of liquid dispensers, including manual, traditional, and nanodispense volumes. The data confirmed the importance of establishing robust QC procedures for dose-response generation in addition to accuracy and precision determinations for each instrument, and they validated the use of nanoliter pipettors for dose-response testing. The results of this study also support the requirement for thorough mixing during serial compound dilutions prepared for high-throughput lead optimization strategies using traditional liquid handlers.

  12. Predicting future space near-IR grism surveys using the WFC3 infrared spectroscopic parallels survey

    Energy Technology Data Exchange (ETDEWEB)

    Colbert, James W.; Atek, Hakim [Spitzer Science Center, California Institute of Technology, Pasadena, CA 91125 (United States); Teplitz, Harry; Rafelski, Marc [Infrared Processing and Analysis Center, Caltech, Pasadena, CA 91125 (United States); Bunker, Andrew [Department of Physics, University of Oxford, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); Ross, Nathaniel; Malkan, Matt [Department of Physics and Astronomy, University of California, Los Angeles, CA (United States); Scarlata, Claudia; Bedregal, Alejandro G. [Minnesota Institute for Astrophysics, University of Minnesota, Minneapolis, MN 55455 (United States); Dominguez, Alberto; Masters, Dan; Siana, Brian [Department of Physics and Astronomy, University of California Riverside, Riverside, CA 92521 (United States); Dressler, Alan; McCarthy, Patrick [Observatories of the Carnegie Institution for Science, Pasadena, CA 91101 (United States); Henry, Alaina [Astrophysics Science Division, Goddard Space Flight Center, Code 665, Greenbelt, MD 20771 (United States); Martin, Crystal L. [Department of Physics, University of California, Santa Barbara, CA 93106 (United States)

    2013-12-10

    We present near-infrared emission line counts and luminosity functions from the Hubble Space Telescope Wide Field Camera 3 Infrared Spectroscopic Parallels (WISP) program for 29 fields (0.037 deg{sup 2}) observed using both the G102 and G141 grism. Altogether we identify 1048 emission line galaxies with observed equivalent widths greater than 40 Å, 467 of which have multiple detected emission lines. We use simulations to correct for significant (>20%) incompleteness introduced in part by the non-dithered, non-rotated nature of the grism parallels. The WISP survey is sensitive to fainter flux levels ((3-5) × 10{sup –17} erg s{sup –1} cm{sup –2}) than the future space near-infrared grism missions aimed at baryonic acoustic oscillation cosmology ((1-4) × 10{sup –16} erg s{sup –1} cm{sup –2}), allowing us to probe the fainter emission line galaxies that the shallower future surveys may miss. Cumulative number counts of 0.7 < z < 1.5 galaxies reach 10,000 deg{sup –2} above an Hα flux of 2 × 10{sup –16} erg s{sup –1} cm{sup –2}. Hα-emitting galaxies with comparable [O III] flux are roughly five times less common than galaxies with just Hα emission at those flux levels. Galaxies with low Hα/[O III] ratios are very rare at the brighter fluxes that future near-infrared grism surveys will probe; our survey finds no galaxies with Hα/[O III] < 0.95 that have Hα flux greater than 3 × 10{sup –16} erg s{sup –1} cm{sup –2}. Our Hα luminosity function contains a comparable number density of faint line emitters to that found by the Near IR Camera and Multi-Object Spectrometer near-infrared grism surveys, but significantly fewer (factors of 3-4 less) high-luminosity emitters. We also find that our high-redshift (z = 0.9-1.5) counts are in agreement with the high-redshift (z = 1.47) narrowband Hα survey of HiZELS (Sobral et al.), while our lower redshift luminosity function (z = 0.3-0.9) falls slightly below their z = 0.84 result. The evolution

  13. The slope parameter of concentration-response curves used as a touchstone for the existence of spare receptors.

    Science.gov (United States)

    Agneter, E; Singer, E A; Sauermann, W; Feuerstein, T J

    1997-09-01

    The present work was stimulated by findings of a large reserve of presynaptic alpha2-autoreceptors in rat neocortex by different investigators and our own group, using classical models of receptor agonism. The mathematical background of these classical models seems erroneous since the asymmetry that spare receptors introduce into concentration-response curves is not considered appropriately. This asymmetry leads to a steepening of curve fits based on the logistic function. Therefore, the slope parameter c of a logistically fitted concentration-response curve can be used as a touchstone for the existence of spare receptors. Spare receptors induce a c > 1. Concentration-response data of the alpha2-autoreceptor-mediated inhibition of evoked [3H]-noradrenaline release in rat neocortex slices were re-analysed. The estimates of the slope parameter c of logistically fitted concentration-response curves obtained after treatment of rats with either vehicle or N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) to achieve an irreversible inactivation of alpha2-autoreceptors, were not compatible with the existence of a large receptor reserve. A model for nonlinear regression analysis developed under the a priori assumption of spare receptors confirmed the absence of spare receptors. Evaluation methods which neglect the alteration of the geometrical form of concentration-response curves due to non-proportionality between receptor occupation and relative response do not seem appropriate to quantify spare receptors. These methods may detect spare receptors where they do not exist.

  14. Patients who do not respond to the "usual" dose: why Terry fell off the dose-response curve.

    Science.gov (United States)

    Preskorn, Sheldon H

    2009-11-01

    Clinical trials are aimed at determining what happens in the "usual" patient; however, clinicians are interested in what happens in their patients even if they are not usual. The usual dose-response relationship is determined as part of the drug development process required for approval of a new drug. However, clinicians are likely to encounter patients who "fall off" the usual dose-response curve because they are either sensitive or resistant to the beneficial (efficacy) or adverse effects of a drug. This column is the first in a series that will examine why specific patients fall off the usual dose-response curve and how clinicians can manage such patients when they encounter them. This column discusses what a dose-response curve is, how it is determined, and why it is clinically important.

  15. Evaluation of the Phase-Dependent Rhythm Control of Human Walking Using Phase Response Curves.

    Directory of Open Access Journals (Sweden)

    Tetsuro Funato

    2016-05-01

    Full Text Available Humans and animals control their walking rhythms to maintain motion in a variable environment. The neural mechanism for controlling rhythm has been investigated in many studies using mechanical and electrical stimulation. However, quantitative evaluation of rhythm variation in response to perturbation at various timings has rarely been investigated. Such a characteristic of rhythm is described by the phase response curve (PRC. Dynamical simulations of human skeletal models with changing walking rhythms (phase reset described a relation between the effective phase reset on stability and PRC, and phase reset around touch-down was shown to improve stability. A PRC of human walking was estimated by pulling the swing leg, but such perturbations hardly influenced the stance leg, so the relation between the PRC and walking events was difficult to discuss. This research thus examines human response to variations in floor velocity. Such perturbation yields another problem, in that the swing leg is indirectly (and weakly perturbed, so the precision of PRC decreases. To solve this problem, this research adopts the weighted spike-triggered average (WSTA method. In the WSTA method, a sequential pulsed perturbation is used for stimulation. This is in contrast with the conventional impulse method, which applies an intermittent impulsive perturbation. The WSTA method can be used to analyze responses to a large number of perturbations for each sequence. In the experiment, perturbations are applied to walking subjects by rapidly accelerating and decelerating a treadmill belt, and measured data are analyzed by the WSTA and impulse methods. The PRC obtained by the WSTA method had clear and stable waveforms with a higher temporal resolution than those obtained by the impulse method. By investigation of the rhythm transition for each phase of walking using the obtained PRC, a rhythm change that extends the touch-down and mid-single support phases is found to occur.

  16. Evaluation of the Phase-Dependent Rhythm Control of Human Walking Using Phase Response Curves.

    Science.gov (United States)

    Funato, Tetsuro; Yamamoto, Yuki; Aoi, Shinya; Imai, Takashi; Aoyagi, Toshio; Tomita, Nozomi; Tsuchiya, Kazuo

    2016-05-01

    Humans and animals control their walking rhythms to maintain motion in a variable environment. The neural mechanism for controlling rhythm has been investigated in many studies using mechanical and electrical stimulation. However, quantitative evaluation of rhythm variation in response to perturbation at various timings has rarely been investigated. Such a characteristic of rhythm is described by the phase response curve (PRC). Dynamical simulations of human skeletal models with changing walking rhythms (phase reset) described a relation between the effective phase reset on stability and PRC, and phase reset around touch-down was shown to improve stability. A PRC of human walking was estimated by pulling the swing leg, but such perturbations hardly influenced the stance leg, so the relation between the PRC and walking events was difficult to discuss. This research thus examines human response to variations in floor velocity. Such perturbation yields another problem, in that the swing leg is indirectly (and weakly) perturbed, so the precision of PRC decreases. To solve this problem, this research adopts the weighted spike-triggered average (WSTA) method. In the WSTA method, a sequential pulsed perturbation is used for stimulation. This is in contrast with the conventional impulse method, which applies an intermittent impulsive perturbation. The WSTA method can be used to analyze responses to a large number of perturbations for each sequence. In the experiment, perturbations are applied to walking subjects by rapidly accelerating and decelerating a treadmill belt, and measured data are analyzed by the WSTA and impulse methods. The PRC obtained by the WSTA method had clear and stable waveforms with a higher temporal resolution than those obtained by the impulse method. By investigation of the rhythm transition for each phase of walking using the obtained PRC, a rhythm change that extends the touch-down and mid-single support phases is found to occur.

  17. Convolution effect on TCR log response curve and the correction method for it

    Science.gov (United States)

    Chen, Q.; Liu, L. J.; Gao, J.

    2016-09-01

    Through-casing resistivity (TCR) logging has been successfully used in production wells for the dynamic monitoring of oil pools and the distribution of the residual oil, but its vertical resolution has limited its efficiency in identification of thin beds. The vertical resolution is limited by the distortion phenomenon of vertical response of TCR logging. The distortion phenomenon was studied in this work. It was found that the vertical response curve of TCR logging is the convolution of the true formation resistivity and the convolution function of TCR logging tool. Due to the effect of convolution, the measurement error at thin beds can reach 30% or even bigger. Thus the information of thin bed might be covered up very likely. The convolution function of TCR logging tool was obtained in both continuous and discrete way in this work. Through modified Lyle-Kalman deconvolution method, the true formation resistivity can be optimally estimated, so this inverse algorithm can correct the error caused by the convolution effect. Thus it can improve the vertical resolution of TCR logging tool for identification of thin beds.

  18. Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function

    Science.gov (United States)

    Rabin, B. M.; Joseph, J. A.; Shukitt-Hale, B.

    2004-01-01

    Exposure to heavy particles can affect the functioning of the central nervous system (CNS), particularly the dopaminergic system. In turn, the radiation-induced disruption of dopaminergic function affects a variety of behaviors that are dependent upon the integrity of this system, including motor behavior (upper body strength), amphetamine (dopamine)-mediated taste aversion learning, and operant conditioning (fixed-ratio bar pressing). Although the relationships between heavy particle irradiation and the effects of exposure depend, to some extent, upon the specific behavioral or neurochemical endpoint under consideration, a review of the available research leads to the hypothesis that the endpoints mediated by the CNS have certain characteristics in common. These include: (1) a threshold, below which there is no apparent effect; (2) the lack of a dose-response relationship, or an extremely steep dose-response curve, depending on the particular endpoint; and (3) the absence of recovery of function, such that the heavy particle-induced behavioral and neural changes are present when tested up to one year following exposure. The current report reviews the data relevant to the degree to which these characteristics are common to neurochemical and behavioral endpoints that are mediated by the effects of exposure to heavy particles on CNS activity.

  19. Phase response curve to 1 h light pulses for the European rabbit (Oryctolagus cuniculus).

    Science.gov (United States)

    Kennedy, Gerard A; Hudson, Robyn

    2016-01-01

    While much is known about the circadian systems of rodents, chronobiological studies of other mammalian groups have been limited. One of the most extensively studied nonrodent species, both in the laboratory and in the wild, is the European rabbit. The aim of this study was to extend knowledge of the rabbit circadian system by examining its phasic response to light. Twelve Dutch-Himalayan cross rabbits of both sexes were allowed to free-run in constant darkness and then administered 1 h light pulses (1000 lux) at multiple predetermined circadian times. Changes in the phase of the rabbits' circadian wheel-running rhythms were measured after each light pulse and used to construct a phase-response curve (PRC). The rabbits' PRC and free-running period (τ) conformed to the empirical regularities reported for other predominantly nocturnal animals, including rodents and predatory marsupials. The results of the study are thus consistent with reports that the rabbit is essentially a nocturnal animal and show that it can entrain to light/dark (LD) cycles via discrete phase shifts. Knowledge about the rabbit's circadian range of entrainment to LD cycles gained in this study will be useful for examining the putative circadian processes believed to underlie the unusual rhythm of very brief, once-daily nest visits by nursing rabbit mothers and other nursing lagomorphs.

  20. Heavy particle irradiation, neurochemistry and behavior: thresholds, dose-response curves and recovery of function

    Science.gov (United States)

    Rabin, B. M.; Joseph, J. A.; Shukitt-Hale, B.

    2004-01-01

    Exposure to heavy particles can affect the functioning of the central nervous system (CNS), particularly the dopaminergic system. In turn, the radiation-induced disruption of dopaminergic function affects a variety of behaviors that are dependent upon the integrity of this system, including motor behavior (upper body strength), amphetamine (dopamine)-mediated taste aversion learning, and operant conditioning (fixed-ratio bar pressing). Although the relationships between heavy particle irradiation and the effects of exposure depend, to some extent, upon the specific behavioral or neurochemical endpoint under consideration, a review of the available research leads to the hypothesis that the endpoints mediated by the CNS have certain characteristics in common. These include: (1) a threshold, below which there is no apparent effect; (2) the lack of a dose-response relationship, or an extremely steep dose-response curve, depending on the particular endpoint; and (3) the absence of recovery of function, such that the heavy particle-induced behavioral and neural changes are present when tested up to one year following exposure. The current report reviews the data relevant to the degree to which these characteristics are common to neurochemical and behavioral endpoints that are mediated by the effects of exposure to heavy particles on CNS activity. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

  1. Dose-response calibration curves of {sup 137}Cs gamma rays for dicentric chromosome aberrations in human lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Wol Soon; Oh, Su Jung; Jeong, Soo Kyun; Yang, Kwang Mo [Dept. of Research center, Dong Nam Institute of Radiological and Medical Sciences, Busan (Korea, Republic of); Jeong, Min Ho [Dept. of Microbiology, Dong A University College of Medicine, Busan (Korea, Republic of)

    2012-11-15

    Recently, the increased threat of radiologically industrial accident such as radiation nondestructive inspection or destruction of nuclear accident by natural disaster such as Fukushima accident requires a greater capacity for cytogenetic biodosimetry, which is critical for clinical triage of potentially thousands of radiation-exposed individuals. Dicentric chromosome aberration analysis is the conventional means of assessing radiation exposure. Dose–response calibration curves for {sup 13}'7Cs gamma rays have been established for unstable chromosome aberrations in human peripheral blood lymphocytes in many laboratories of international biodosimetry network. In this study, therefore, we established dose– response calibration curves of our laboratory for {sup 137}Cs gamma raysaccording to the IAEA protocols for conducting the dicentric chromosome assay We established in vitro dose–response calibration curves for dicentric chromosome aberrations in human lymphocytes for{sup 13}'7Cs gamma rays in the 0 to 5 Gy range, using the maximum likelihood linear-quadratic model, Y = c+αD+βD2. The estimated coefficients of the fitted curves were within the 95% confidence intervals (CIs) and the curve fitting of dose–effect relationship data indicated a good fit to the linear-quadratic model. Hence, meaningful dose estimation from unknown sample can be determined accurately by using our laboratory’s calibration curve according to standard protocol.

  2. Effect of Phase Response Curve Skew on Synchronization with and without Conduction Delays

    Directory of Open Access Journals (Sweden)

    Carmen eCanavier

    2013-12-01

    Full Text Available A central problem in cortical processing including sensory binding and attentional gating is how neurons can synchronize their responses with zero or near-zero time lag. For a spontaneously firing neuron, an input from another neuron can delay or advance the next spike by different amounts depending upon the timing of the input relative to the previous spike. This information constitutes the phase response curve (PRC. We present a simple graphical method for determining the effect of PRC shape on synchronization tendencies and illustrate it using type 1 PRCs, which consist entirely of advances (delays in response to excitation (inhibition. We obtained the following generic solutions for type 1 PRCs, which include the pulse coupled leaky integrate and fire model. For pairs with mutual excitation, exact synchrony can be stable for strong coupling because of the stabilizing effect of the causal limit region of the PRC in which an input triggers a spike immediately upon arrival. However, synchrony is unstable for short delays, because delayed inputs arrive during a refractory period and cannot trigger an immediate spike. Right skew destabilizes antiphase and enables modes with time lags that grow as the conduction delay is increased. Therefore, right skew favors near-synchrony at short conduction delays and a gradual transition between synchrony and antiphase for pairs coupled by mutual excitation. For pairs with mutual inhibition, zero time lag synchrony is stable for conduction delays ranging from zero to a substantial fraction of the period for pairs. However, for right skew there is a preferred antiphase mode at short delays. In contrast to mutual excitation, left skew destabilizes antiphase for mutual inhibition so that synchrony dominates at short delays as well. These pairwise synchronization tendencies constrain the synchronization properties of neurons embedded in larger networks.

  3. Steepness of the radiation dose-response curve for dose-per-fraction escalation keeping the number of fractions fixed.

    Science.gov (United States)

    Bentzen, Søren M

    2005-01-01

    Clinically, there is growing interest in strategies for intensifying radiation therapy by escalating the dose per fraction. This paper considers the steepness of the dose-response curve in this case. The steepness of a radiation dose-response curve is most conveniently quantified by the normalized dose-response gradient, gamma. Under the assumption of a linear-quadratic dose-effect model, a simple analytical relationship is derived between the gamma-value for a dose-response curve generated by varying the total dose while keeping the number of fractions constant, i.e. escalating the dose per fraction, and the gamma-value for a dose-response curve generated by varying the total dose while keeping the dose per fraction constant. This formulation is compared with clinical dose-response data from the literature and shown to be in good agreement with the observations. Some implications of this formulation for non-uniform dose distributions delivered using 3D conformal radiotherapy or intensity modulated radiotherapy (IMRT) are briefly discussed.

  4. Finite-time Lyapunov exponents and metabolic control coefficients for threshold detection of stimulus-response curves.

    Science.gov (United States)

    Duc, Luu Hoang; Chávez, Joseph Páez; Son, Doan Thai; Siegmund, Stefan

    2016-01-01

    In biochemical networks transient dynamics plays a fundamental role, since the activation of signalling pathways is determined by thresholds encountered during the transition from an initial state (e.g. an initial concentration of a certain protein) to a steady-state. These thresholds can be defined in terms of the inflection points of the stimulus-response curves associated to the activation processes in the biochemical network. In the present work, we present a rigorous discussion as to the suitability of finite-time Lyapunov exponents and metabolic control coefficients for the detection of inflection points of stimulus-response curves with sigmoidal shape.

  5. Multidimensional representations of the phase response curve for both type 1 and type 2 membrane excitability

    Science.gov (United States)

    Raidt, Robert; Smith, Andrew J.; Oprisan, Sorinel A.

    2012-02-01

    Neurons are complex excitable cells with a highly nonlinear response to external perturbations, such as presynaptic inputs and biological noise. Single-cell activity is determined by the properties of ionic channels and the ionic makeup of cell's environment and is mathematically described by coupled and nonlinear evolution equations. The phase resetting curve (PRC) reduces the complexity of the biophysical mechanisms involved in generating action potentials to tabulating advances or delays of subsequent spikes of a neuron due to an external perturbation. The PRC is widely used to predict the activity of large neural networks that by replacing the computationally intensive integration of evolution equations with lookup tables. The fundamental assumption of the PRC approach in predicting phase-locked modes in coupled neural networks is that the transient PRC measured for isolated and bursting neurons (open-loop) remains the same under the recurrent inputs of a phase-locked mode (close-loop). The novelties of our approach are: 1) the use of discrete sine transforms (DST's) to store the PRC's as a series of coefficients, and 2) the use of multidimensional stacks to represent multidimensional objects.

  6. An interactive computer program for randomization analysis of response curves with facilities for multiple comparisons.

    Science.gov (United States)

    Tan, E S; Roos, J M; Volovics, A; Van Baak, M A; Does, R J

    1992-04-01

    An interactive Fortran program, MUCRA, is presented. The program can perform randomization analysis of a completely randomized or randomized-blocks design extended to growth and response curves. A single-step Scheffé-type procedure as well as the Peritz's closed step-down procedure have been implemented which control the familywise type I error-rate. In general, MUCRA is suitable as a computer tool for a distribution-free analysis of variance with repeated measures. The use of MUCRA is demonstrated by analyzing the effects oxprenolol and atenolol have on exercise heart rate. Oxprenolol is a non-selective beta-blocker with moderate intrinsic sympathomimetic activity (ISA), given by the Oros delivery system. Atenolol is a beta 1-selective blocker without ISA. A randomized placebo-controlled crossover design was used to compare the effects of the beta 1-blockers on heart rate during a progressive maximal exercise test on a bicycle ergometer. Application of the Scheffé-type procedure showed that the two drugs significantly (alpha = .05) reduce the heart rate during the exercise test at the three prechosen times (2, 5, and 24 hr) after intake. The reduction from atenolol is more pronounced than from oxprenolol Oros at 2 and 5 hr.

  7. Dose-response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies.

    Science.gov (United States)

    Webb, Nicholas E; Montefiori, David C; Lee, Benhur

    2015-09-29

    A new generation of HIV broadly neutralizing antibodies (bnAbs) with remarkable potency, breadth and epitope diversity has rejuvenated interest in immunotherapeutic strategies. Potencies defined by in vitro IC50 and IC80 values (50 and 80% inhibitory concentrations) figure prominently into the selection of clinical candidates; however, much higher therapeutic levels will be required to reduce multiple logs of virus and impede escape. Here we predict bnAb potency at therapeutic levels by analysing dose-response curve slopes, and show that slope is independent of IC50/IC80 and specifically relates to bnAb epitope class. With few exceptions, CD4-binding site and V3-glycan bnAbs exhibit slopes >1, indicative of higher expected therapeutic effectiveness, whereas V2-glycan, gp41 membrane-proximal external region (MPER) and gp120-gp41 bnAbs exhibit less favourable slopes <1. Our results indicate that slope is one major predictor of both potency and breadth for bnAbs at clinically relevant concentrations, and may better coordinate the relationship between bnAb epitope structure and therapeutic expectations.

  8. Mechanism Underlying Time-dependent Cross-phenomenon between Concentration-response Curves and Concentration Addition Curves: A Case Study of Sulfonamides-Erythromycin mixtures on Escherichia coli

    Science.gov (United States)

    Sun, Haoyu; Ge, Hongming; Zheng, Min; Lin, Zhifen; Liu, Ying

    2016-09-01

    Previous studies have identified a phenomenon in which the concentration-response curves (CRCs) for mixtures cross the curves for concentration addition model when predicting or judging joint toxic actions. However, mechanistic investigations of this phenomenon are extremely limited. In this study, a similar phenomenon was observed when we determined the joint toxic actions of sulfonamides (SAs) and erythromycin (ERY) on Escherichia coli (E. coli), which we named the “cross-phenomenon”, and it was characterized by antagonism in the low-concentration range, addition in the medium-concentration range, and synergism in the high-concentration range. The mechanistic investigation of the cross-phenomenon was as follows: SAs and ERY could form a double block to inhibit the bacterial growth by exhibiting a synergistic effect; however, the hormetic effect of SAs on E. coli led to antagonism in the low-concentration range, resulting from the stimulation of sdiA mRNA expression by SAs, which increased the expression of the efflux pump (AcrAB-TolC) to discharge ERY. Furthermore, this cross-phenomenon was observed to be a time-dependent process induced by the increase of both the concentration and extent of stimulation of sdiA mRNA with exposure time. This work explains the dose-dependent and time-dependent cross-phenomenon and provides evidence regarding the interaction between hormesis and cross-phenomenon.

  9. Differential thermal performance curves in response to different habitats in the parasitoid Venturia canescens

    Science.gov (United States)

    Foray, Vincent; Gibert, Patricia; Desouhant, Emmanuel

    2011-08-01

    Environmental variability is expected to be important in shaping performance curves, reaction norms of phenotypic traits related to fitness. Models predict that the breadth of performance curves should increase with environmental variability at the expense of maximal performance. In this study, we compared the thermal performance curves of two sympatric populations of the parasitoid Venturia canescens that were observed under contrasting thermal regimes in their respective preferred habitats and differing in their modes of reproduction. Our results confirm the large effect of developmental temperature on phenotypic traits of insects and demonstrate that thelytokous and arrhenotokous wasps respond differently to temperature during development, in agreement with model predictions. For traits related to fecundity, thelytokous parasitoids, which usually occur in stable thermal conditions, exhibit specialist performance curves, maximising their reproductive success under a restricted range of temperature. In contrast, arrhenotokous parasitoids, which occur in variable climates, exhibit generalist performance curves, in keeping with the hypothesis "jack of all temperatures, master of none".

  10. A dose-response curve for biodosimetry from a 6 MV electron linear accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Lemos-Pinto, M.M.P.; Cadena, M.; Santos, N.; Fernandes, T.S.; Borges, E.; Amaral, A., E-mail: marcelazoo@yahoo.com.br [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Departamento de Energia Nuclear

    2015-10-15

    Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET) and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA). Two software programs, CABAS (Chromosomal Aberration Calculation Software) and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates. (author)

  11. A dose-response curve for biodosimetry from a 6 MV electron linear accelerator

    Science.gov (United States)

    Lemos-Pinto, M.M.P.; Cadena, M.; Santos, N.; Fernandes, T.S.; Borges, E.; Amaral, A.

    2015-01-01

    Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET) and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA). Two software programs, CABAS (Chromosomal Aberration Calculation Software) and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates. PMID:26445334

  12. A dose-response curve for biodosimetry from a 6 MV electron linear accelerator.

    Science.gov (United States)

    Lemos-Pinto, M M P; Cadena, M; Santos, N; Fernandes, T S; Borges, E; Amaral, A

    2015-10-01

    Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET) and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA). Two software programs, CABAS (Chromosomal Aberration Calculation Software) and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates.

  13. A dose-response curve for biodosimetry from a 6 MV electron linear accelerator

    Directory of Open Access Journals (Sweden)

    M.M.P. Lemos-Pinto

    2015-01-01

    Full Text Available Biological dosimetry (biodosimetry is based on the investigation of radiation-induced biological effects (biomarkers, mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA. Two software programs, CABAS (Chromosomal Aberration Calculation Software and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates.

  14. Estimation of a Ramsay-Curve Item Response Theory Model by the Metropolis-Hastings Robbins-Monro Algorithm

    Science.gov (United States)

    Monroe, Scott; Cai, Li

    2014-01-01

    In Ramsay curve item response theory (RC-IRT) modeling, the shape of the latent trait distribution is estimated simultaneously with the item parameters. In its original implementation, RC-IRT is estimated via Bock and Aitkin's EM algorithm, which yields maximum marginal likelihood estimates. This method, however, does not produce the…

  15. Estimation of a Ramsay-Curve Item Response Theory Model by the Metropolis-Hastings Robbins-Monro Algorithm

    Science.gov (United States)

    Monroe, Scott; Cai, Li

    2014-01-01

    In Ramsay curve item response theory (RC-IRT) modeling, the shape of the latent trait distribution is estimated simultaneously with the item parameters. In its original implementation, RC-IRT is estimated via Bock and Aitkin's EM algorithm, which yields maximum marginal likelihood estimates. This method, however, does not produce the…

  16. Influence of lung parenchymal destruction on the different indexes of the methacholine dose-response curve in COPD patients

    NARCIS (Netherlands)

    G.T. Verhoeven; A.F.M. Verbraak (Anton); S. Boere-van der Straat; H.C. Hoogsteden (Henk); J.M. Bogaard (Jan)

    2000-01-01

    textabstractSTUDY OBJECTIVES: The interpretation of nonspecific bronchial provocation dose-response curves in COPD is still a matter of debate. Bronchial hyperresponsiveness (BHR) in patients with COPD could be influenced by the destruction of the parenchyma and the aug

  17. Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application.

    Science.gov (United States)

    Luszczki, Jarogniew J

    2007-04-01

    The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice. The anticonvulsant and acute adverse effects of the combination of TPM with GBP at the fixed ratio of 1:1 were determined using the type I isobolographic analysis for nonparallel dose-response relationship curves (DRRCs). To ascertain any pharmacokinetic contribution to the observed interaction between TPM and GBP, total brain concentrations of both drugs were determined. The isobolographic analysis of interaction for TPM and GBP, whose DRRCs were not parallel in both MES and chimney tests, was accompanied with a presentation of all required calculations allowing the determination of lower and upper lines of additivity. The isobolographic analysis revealed that TPM combined with GBP at the fixed-ratio combination of 1:1 interacted supraadditively (synergistically) in terms of suppression of MES-induced seizures, and simultaneously, the combination produced additive interaction with respect to motor coordination impairment (adverse effects) in the chimney test. The evaluation of pharmacokinetic characteristics of interaction for the combination of TPM with GBP revealed that neither TPM nor GBP affected their total brain concentrations in experimental animals, and thus, the observed interaction in the MES test was pharmacodynamic in nature. In conclusion, the combination of TPM with GBP, because of supraadditivity in the MES test and additivity in terms of motor coordination impairment in the chimney test as well as lack of pharmacokinetic interactions between drugs, fulfilled the criterion of a favorable combination, worthy of recommendation in further clinical practice.

  18. A phase response curve to single bright light pulses in human subjects

    Science.gov (United States)

    Khalsa, Sat Bir S.; Jewett, Megan E.; Cajochen, Christian; Czeisler, Charles A.

    2003-01-01

    The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported human phase response curves (PRCs) to single bright light exposures have employed small sample sizes, and were often based on relatively imprecise estimates of circadian phase and phase resetting. In the present study, 21 healthy, entrained subjects underwent pre- and post-stimulus constant routines (CRs) in dim light (approximately 2-7 lx) with maintained wakefulness in a semi-recumbent posture. The 6.7 h bright light exposure stimulus consisted of alternating 6 min fixed gaze (approximately 10 000 lx) and free gaze (approximately 5000-9000 lx) exposures. Light exposures were scheduled across the circadian cycle in different subjects so as to derive a PRC. Plasma melatonin was used to determine the phase of the onset, offset, and midpoint of the melatonin profiles during the CRs. Phase shifts were calculated as the difference in phase between the pre- and post-stimulus CRs. The resultant PRC of the midpoint of the melatonin rhythm revealed a characteristic type 1 PRC with a significant peak-to-trough amplitude of 5.02 h. Phase delays occurred when the light stimulus was centred prior to the critical phase at the core body temperature minimum, phase advances occurred when the light stimulus was centred after the critical phase, and no phase shift occurred at the critical phase. During the subjective day, no prolonged 'dead zone' of photic insensitivity was apparent. Phase shifts derived using the melatonin onsets showed larger magnitudes than those derived from the melatonin offsets. These data provide a comprehensive characterization of the human PRC under highly controlled laboratory conditions.

  19. 3D-HST: A wide-field grism spectroscopic survey with the Hubble Space Telescope

    CERN Document Server

    Brammer, Gabriel; Franx, Marijn; Fumagalli, Mattia; Patel, Shannon; Rix, Hans-Walter; Skelton, Rosalind; Kriek, Mariska; Nelson, Erica; Schmidt, Kasper; Bezanson, Rachel; da Cunha, Elisabete; Erb, Dawn; Fan, Xiaohui; Schreiber, Natascha Förster; Illingworth, Garth; Labbé, Ivo; Leja, Joel; Lundgren, Britt; Magee, Dan; Marchesini, Danilo; McCarthy, Patrick; Momcheva, Ivelina; Muzzin, Adam; Quadri, Ryan; Steidel, Charles; Tal, Tomer; Wake, David; Whitaker, Katherine; Williams, Anna

    2012-01-01

    We present 3D-HST, a near-infrared spectroscopic Treasury program with the Hubble Space Telescope for studying the processes that shape galaxies in the distant Universe. 3D-HST provides rest-frame optical spectra for a sample of ~7000 galaxies at 1grism coverage and two to four parallel orbits with the ACS/G800L grism. In the IR these exposure times yield a continuum signal-to-noise of ~5 per resolution element at H~23.1 and a 5sigma emission line sensitivity of 5x10-17 erg/s/cm2 for typical objects, improving by a factor of ~2 for compact sources in images with low sky background levels. The WFC3/G141 spectra provide continuous wavelength coverage from 1.1-1.6 um at a spatial resolution...

  20. Predicting Future Space Near-IR Grism Surveys using the WFC3 Infrared Spectroscopic Parallels Survey

    CERN Document Server

    Colbert, James W; Atek, Hakim; Bunker, Andrew; Rafelski, Marc; Ross, Nathaniel; Scarlata, Claudia; Bedregal, Alejandro; Dominguez, Alberto; Dressler, Alan; Henry, Alaina; Malkan, Matt; Martin, Crystal L; Masters, Dan; McCarthy, Patrick; Siana, Brian

    2013-01-01

    We present near-infrared emission line counts and luminosity functions from the HST WFC3 Infrared Spectroscopic Parallels (WISP) program for 29 fields observed using both the G102 and G141 grism. Altogether we identify 1048 emission line galaxies with observed equivalent widths greater than 40 Angstroms, 467 of which have multiple detected emission lines. The WISP survey is sensitive to fainter flux levels (3-5x10^{-17} ergs/s/cm^2) than the future space near-infrared grism missions aimed at baryonic acoustic oscillation cosmology (1-4x10^{-16} ergs/s/cm^2), allowing us to probe the fainter emission line galaxies that the shallower future surveys may miss. Cumulative number counts of 0.7

  1. A LYMAN BREAK GALAXY IN THE EPOCH OF REIONIZATION FROM HUBBLE SPACE TELESCOPE GRISM SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    Rhoads, James E.; Malhotra, Sangeeta; Cohen, Seth; Zheng Zhenya [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287 (United States); Stern, Daniel [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Dickinson, Mark [National Optical Astronomy Observatory, Tucson, AZ (United States); Pirzkal, Norbert; Grogin, Norman; Koekemoer, Anton; Peth, Michael A. [Space Telescope Science Institute, Baltimore, MD (United States); Spinrad, Hyron [University of California, Berkeley, CA (United States); Reddy, Naveen [University of California, Riverside, CA (United States); Hathi, Nimish [Observatories of the Carnegie Institution of Washington, Pasadena, CA (United States); Budavari, Tamas [Johns Hopkins University, Baltimore, MD (United States); Ferreras, Ignacio [Mullard Space Science Laboratory, University College London, Holmbury St Mary, Dorking, Surrey RH5 6NT (United Kingdom); Gardner, Jonathan P. [NASA Goddard Space Flight Center, Astrophysics Science Division, Observational Cosmology Laboratory, Code 665, Greenbelt, MD 20771 (United States); Gronwall, Caryl [Department of Astronomy and Astrophysics, and Institute for Gravitation and the Cosmos, The Pennsylvania State University, University Park, PA 16802 (United States); Haiman, Zoltan [Columbia University, New York, NY (United States); Kuemmel, Martin [Universitaets-Sternwarte Muenchen, Scheinerstr. 1, D-81679 Muenchen (Germany); Meurer, Gerhardt, E-mail: James.Rhoads@asu.edu [International Centre for Radio Astronomy Research, University of Western Australia, M468, 35 Stirling Highway, Crawley, WA 6009 (Australia); and others

    2013-08-10

    We present observations of a luminous galaxy at z = 6.573-the end of the reionization epoch-which has been spectroscopically confirmed twice. The first spectroscopic confirmation comes from slitless Hubble Space Telescope Advanced Camera for Surveys grism spectra from the PEARS survey (Probing Evolution And Reionization Spectroscopically), which show a dramatic continuum break in the spectrum at rest frame 1216 A. The second confirmation is done with Keck + DEIMOS. The continuum is not clearly detected with ground-based spectra, but high wavelength resolution enables the Ly{alpha} emission line profile to be determined. We compare the line profile to composite line profiles at z = 4.5. The Ly{alpha} line profile shows no signature of a damping wing attenuation, confirming that the intergalactic gas is ionized at z = 6.57. Spectra of Lyman breaks at yet higher redshifts will be possible using comparably deep observations with IR-sensitive grisms, even at redshifts where Ly{alpha} is too attenuated by the neutral intergalactic medium to be detectable using traditional spectroscopy from the ground.

  2. Plant Photosynthesis-Irradiance Curve Responses to Pollution Show Non-Competitive Inhibited Michaelis Kinetics.

    Science.gov (United States)

    Lin, Maozi; Wang, Zhiwei; He, Lingchao; Xu, Kang; Cheng, Dongliang; Wang, Genxuan

    2015-01-01

    Photosynthesis-irradiance (PI) curves are extensively used in field and laboratory research to evaluate the photon-use efficiency of plants. However, most existing models for PI curves focus on the relationship between the photosynthetic rate (Pn) and photosynthetically active radiation (PAR), and do not take account of the influence of environmental factors on the curve. In the present study, we used a new non-competitive inhibited Michaelis-Menten model (NIMM) to predict the co-variation of Pn, PAR, and the relative pollution index (I). We then evaluated the model with published data and our own experimental data. The results indicate that the Pn of plants decreased with increasing I in the environment and, as predicted, were all fitted well by the NIMM model. Therefore, our model provides a robust basis to evaluate and understand the influence of environmental pollution on plant photosynthesis.

  3. Plant Photosynthesis-Irradiance Curve Responses to Pollution Show Non-Competitive Inhibited Michaelis Kinetics.

    Directory of Open Access Journals (Sweden)

    Maozi Lin

    Full Text Available Photosynthesis-irradiance (PI curves are extensively used in field and laboratory research to evaluate the photon-use efficiency of plants. However, most existing models for PI curves focus on the relationship between the photosynthetic rate (Pn and photosynthetically active radiation (PAR, and do not take account of the influence of environmental factors on the curve. In the present study, we used a new non-competitive inhibited Michaelis-Menten model (NIMM to predict the co-variation of Pn, PAR, and the relative pollution index (I. We then evaluated the model with published data and our own experimental data. The results indicate that the Pn of plants decreased with increasing I in the environment and, as predicted, were all fitted well by the NIMM model. Therefore, our model provides a robust basis to evaluate and understand the influence of environmental pollution on plant photosynthesis.

  4. QSAR study on the non-monotonic dose-response curve of PCBs in chicken embryo hepatocyte bioassay

    Institute of Scientific and Technical Information of China (English)

    MU YunSong; ZHANG AiQian; GAO ChangAn; PENG SuFen; WANG LianSheng

    2009-01-01

    Endocrine disrupting chemicals (EDCs) in the natural environment exhibit a unique non-monotonic dose-response curve and it is impossible to select one simple index to characterize the bilogogical activity of these compounds. Quantitative structure-activity relationship (QSAR) study on non-monotonic dose-response curve has become a real challenge presently. In order to explore the possible mechanism for the non-monotonic dose-response curve of polychlorinated biphenyls con-geners (PCBs) in chicken embryo hepatocyte bioassay, AM1 method of ChemOffice was adopted to calculate necessary structure descriptors for PCBs, while the interactions between PCBs and simulated AhR ligand binding domain (LBD) were analyzed by using FlexX in SYBYL7.0. Different binding modes for PCBs have been distinguished not only from aligned conformation but also from free binding energy. Some QSAR models were established separately for both low and high doses ranges, revealing that receptor binding may predominate in the interference of the physiological function of cytochrome P4501A-P4501A in the low doses range. But with the higher doses range, the EROD suppression might he related to acute toxicity owing to molecular polarity or distribution of charges and consequently damage structure and function of chicken embryo hepatocyte.

  5. QSAR study on the non-monotonic dose-response curve of PCBs in chicken embryo hepatocyte bioassay

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Endocrine disrupting chemicals (EDCs) in the natural environment exhibit a unique non-monotonic dose-response curve and it is impossible to select one simple index to characterize the bilogogical activity of these compounds. Quantitative structure-activity relationship (QSAR) study on non-monotonic dose-response curve has become a real challenge presently. In order to explore the possible mechanism for the non-monotonic dose-response curve of polychlorinated biphenyls congeners (PCBs) in chicken embryo hepatocyte bioassay, AM1 method of ChemOffice was adopted to calculate necessary structure descriptors for PCBs, while the interactions between PCBs and simulated AhR ligand binding domain (LBD) were analyzed by using FlexX in SYBYL7.0. Different binding modes for PCBs have been distinguished not only from aligned conformation but also from free binding energy. Some QSAR models were established separately for both low and high doses ranges, revealing that receptor binding may predominate in the interference of the physiological function of cytochrome P4501A-P4501A in the low doses range. But with the higher doses range, the EROD suppression might be related to acute toxicity owing to molecular polarity or distribution of charges and consequently damage structure and function of chicken embryo hepatocyte.

  6. 'Abnormal' angle response curves of TW/Rs for near zero tilt and high tilt channeling implants

    Energy Technology Data Exchange (ETDEWEB)

    Guo Baonian; Gossmann, Hans-Joachim; Toh, Terry; Colombeau, Benjamin; Todorov, Stan; Sinclair, Frank; Shim, Kyu-Ha; Henry, Todd [Applied Materials - Varian Semiconductor Equipment, 35 Dory Road, Gloucester, MA 01930 (United States)

    2012-11-06

    Angle control has been widely accepted as the key requirement for ion implantation in semiconductor device processing. From an ion implanter point of view, the incident ion direction should be measured and corrected by suitable techniques, such as XP-VPS for the VIISta implanter platform, to ensure precision ion placement in device structures. So called V-curves have been adopted to generate the wafer-based calibration using channeling effects as the Si lattice steer ions into a channeling direction. Thermal Wave (TW) or sheet resistance (Rs) can be used to determine the minimum of the angle response curve. Normally it is expected that the TW and Rs have their respective minima at identical angles. However, the TW and Rs response to the angle variations does depend on factors such as implant species, dose, and wafer temperature. Implant damage accumulation effects have to be considered for data interpretation especially for some 'abnormal' V-curve data. In this paper we will discuss some observed 'abnormal' angle responses, such as a) TW/Rs reverse trend for Arsenic beam, 2) 'W' shape of Rs Boron, and 3) apparent TW/Rs minimum difference for high tilt characterization, along with experimental data and TCAD simulations.

  7. Establishment of a Dose-response Curve for X-ray-Induced Micronuclei in Human Lymphocytes.

    Science.gov (United States)

    Lusiyanti, Yanti; Alatas, Zubaidah; Syaifudin, Mukh; Purnami, Sofiati

    2016-01-01

    The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is an established technique for biodosimetry. The aim of this project was to generate a X-ray induced micronuclei (MN) curve for peripheral blood lymphocytes taken from five healthy donors. The blood samples were irradiated with X-rays of 122 KeV at a dose rate of 0.652 Gy/min to doses of 0.5, 1, 2, 3, and 4 Gy. The blood samples were then cultured for 72 h at 37°C and processed following the International Atomic Energy Agency standard procedure with slight modifications. The result showed that the yields of MN frequencies were increased with the increase of radiation dose. Reconstruction of the relationship of MN with dose was fitted to a linear-quadratic model using Chromosome Aberration Calculation Software version 2.0. Due to their advantages, mainly, the dependence on radiation dose and dose rate, despite their limitation, these curves will be useful as alternative method for in vitro dose reconstruction and can support the preparedness for public or occupational radiation overexposure and protection. The results reported here also give us confidence to apply the obtained calibration curve of MN for future biological dosimetry requirements in Indonesia.

  8. Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance.

    Science.gov (United States)

    Sampah, Maame Efua S; Shen, Lin; Jilek, Benjamin L; Siliciano, Robert F

    2011-05-03

    HIV-1 drug resistance is a major clinical problem. Resistance is evaluated using in vitro assays measuring the fold change in IC(50) caused by resistance mutations. Antiretroviral drugs are used at concentrations above IC(50), however, and inhibition at clinical concentrations can only be predicted from IC(50) if the shape of the dose-response curve is also known. Curve shape is influenced by cooperative interactions and is described mathematically by the slope parameter or Hill coefficient (m). Implicit in current analysis of resistance is the assumption that mutations shift dose-response curves to the right without affecting the slope. We show here that m is altered by resistance mutations. For reverse transcriptase and fusion inhibitors, single resistance mutations affect both slope and IC(50). For protease inhibitors, single mutations primarily affect slope. For integrase inhibitors, only IC(50) is affected. Thus, there are fundamental pharmacodynamic differences in resistance to different drug classes. Instantaneous inhibitory potential (IIP), the log inhibition of single-round infectivity at clinical concentrations, takes into account both slope and IC(50), and thus provides a direct measure of the reduction in susceptibility produced by mutations and the residual activity of drugs against resistant viruses. The standard measure, fold change in IC(50), does not correlate well with changes in IIP when mutations alter slope. These results challenge a fundamental assumption underlying current analysis of HIV-1 drug resistance and suggest that a more complete understanding of how resistance mutations reduce antiviral activity requires consideration of a previously ignored parameter, the dose-response curve slope.

  9. Comparing the WFC3 IR Grism Stare and Spatial-Scan Observations for Exoplanet Characterization

    CERN Document Server

    Swain, Mark R; Wagstaff, Kiri L

    2013-01-01

    We report on a detailed study of the measurement stability for WFC3 IR grism stare and spatial scan observations. The excess measurement noise for both modes is established by comparing the observed and theoretical measurement uncertainties. We find that the stare-mode observations produce differential measurements that are consistent and achieve $\\sim\\,1.3$ times photon-limited measurement precision. In contrast, the spatial-scan mode observations produce measurements which are inconsistent, non-Gaussian, and have higher excess noise corresponding to $\\sim\\,2$ times the photon-limited precision. The inferior quality of the spatial scan observations is due to spatial-temporal variability in the detector performance which we measure and map. The non-Gaussian nature of spatial scan measurements makes the use of $\\chi^2$ and the determination of formal confidence intervals problematic and thus renders the comparison of spatial scan data with theoretical models or other measurements difficult. With better measure...

  10. Trace and Wavelength Calibrations of the UVIS G280 +1/-1 Grism Orders

    Science.gov (United States)

    Pirzkal, Norbert; Hilbert, Bryan; Rothberg, Barry

    2017-06-01

    We present new calibrations of the UVIS G280 grism dispersions for the -1 and +1 orders. The new calibration is based on in-flight observations of the star WR14 which was observed at multiple positions on the UVIS detector. This allowed us to derive a first estimate of the field dependence of the UVIS G280 dispersion. While previous, TV3 ground test based calibration, were only able to calibrate spectra obtained at the center of the UVIS CHIP1, our new solutions allow for the extraction and wavelength calibration of spectra over the entire UVIS field-of-view. We estimate the accuracy of the wavelength calibration using the new V2.0 dispersion solutions to be ± 7Å, or about half of a UVIS resolution element.

  11. The cytokinesis-blocked micronucleus assay: dose-response calibration curve, background frequency in the population and dose estimation.

    Science.gov (United States)

    Rastkhah, E; Zakeri, F; Ghoranneviss, M; Rajabpour, M R; Farshidpour, M R; Mianji, F; Bayat, M

    2016-03-01

    An in vitro study of the dose responses of human peripheral blood lymphocytes was conducted with the aim of creating calibrated dose-response curves for biodosimetry measuring up to 4 Gy (0.25-4 Gy) of gamma radiation. The cytokinesis-blocked micronucleus (CBMN) assay was employed to obtain the frequencies of micronuclei (MN) per binucleated cell in blood samples from 16 healthy donors (eight males and eight females) in two age ranges of 20-34 and 35-50 years. The data were used to construct the calibration curves for men and women in two age groups, separately. An increase in micronuclei yield with the dose in a linear-quadratic way was observed in all groups. To verify the applicability of the constructed calibration curve, MN yields were measured in peripheral blood lymphocytes of two real overexposed subjects and three irradiated samples with unknown dose, and the results were compared with dose values obtained from measuring dicentric chromosomes. The comparison of the results obtained by the two techniques indicated a good agreement between dose estimates. The average baseline frequency of MN for the 130 healthy non-exposed donors (77 men and 55 women, 20-60 years old divided into four age groups) ranged from 6 to 21 micronuclei per 1000 binucleated cells. Baseline MN frequencies were higher for women and for the older age group. The results presented in this study point out that the CBMN assay is a reliable, easier and valuable alternative method for biological dosimetry.

  12. Assessment of Pulse Echo Response of Flat Bottom Holes Through Curved Interfaces Using the Patch Element Model

    Science.gov (United States)

    Madhu, G.; Reddy, Sudhan; Krishnamurthy, C. V.; Balasubramaniam, Krishnan

    2009-03-01

    The World Federations of Non-Destructive Evaluations Centers (WFNDEC) has proposed two studies for 2008 Benchmark problem. The first study deals with surface curvature effects across fluid-solid media to evaluate immersion transducer's P-wave response from Flat Bottom Holes (FBH) situated in the solid medium. The second study pertains to pulse echo response from Side Drilled Holes (SDH). We report the results for P-wave response from a FBH due to a transducer placed above a curved interface using the frequency domain Patch Element Model (PEM), developed at CNDE at IITM. The assessment employs an optimized algorithm to determine the points of reflection/refraction on any planar or curved interface between two media and incorporates the Divergence Factor (DF) to account for curvature effects on the field assessment. We also report results on the 2007 benchmark problem dealing with the response from FBH which has two parts: One is model based study and the other is comparison of model with experiments. The PEM results for 2007 and 2008 are compared with the available results from experiments and other models.

  13. Vibration analysis and transient response of a functionally graded piezoelectric curved beam with general boundary conditions

    Science.gov (United States)

    Su, Zhu; Jin, Guoyong; Ye, Tiangui

    2016-06-01

    The paper presents a unified solution for free and transient vibration analyses of a functionally graded piezoelectric curved beam with general boundary conditions within the framework of Timoshenko beam theory. The formulation is derived by means of the variational principle in conjunction with a modified Fourier series which consists of standard Fourier cosine series and supplemented functions. The mechanical and electrical properties of functionally graded piezoelectric materials (FGPMs) are assumed to vary continuously in the thickness direction and are estimated by Voigt’s rule of mixture. The convergence, accuracy and reliability of the present formulation are demonstrated by comparing the present solutions with those from the literature and finite element analysis. Numerous results for FGPM beams with different boundary conditions, geometrical parameters as well as material distributions are given. Moreover, forced vibration of the FGPM beams subjected to dynamic loads and general boundary conditions are also investigated.

  14. Elastic response and wrinkling onset of curved elastic membranes subjected to indentation test.

    Science.gov (United States)

    Bernal, R; Tassius, Ch; Melo, F; Géminard, J-Ch

    2011-02-01

    Starting from a polymeric-fluid droplet, by vulcanization of the fluid free surface, curved elastic membranes, several nanometers thick and a few millimeters in diameter, which enclose a constant fluid volume, are produced. In an indentation-type test, carried out by pushing the membrane along its normal by means of a micro-needle, under some conditions, wrinkles are likely to appear around the contact region. Interestingly, we observe that the instability does not significantly alter the force-displacement relation: the relation between the force and the displacement remains linear and the associated stiffness is simply proportional to the tension of the membrane. In addition, we determine that the wrinkles develop when the stretching modulus of the membrane compares with its tension, which provides a useful method to estimate the elastic constant.

  15. AN ITEM RESPONSE MODEL WITH SINGLE PEAKED ITEM CHARACTERISTIC CURVES - THE PARELLA MODEL

    NARCIS (Netherlands)

    HOIJTINK, H; MOLENAAR, [No Value

    In this paper an item response model (the PARELLA model) designed specifically for the measurement of attitudes and preferences will be introduced. In contrast with the item response models currently used (e.g. the Rasch model and, the two and three parameter logistic model) the item characteristic

  16. Low blood lead level effects on intelligence: can a dose-response curve be determined from the epidemiological data?

    Science.gov (United States)

    Banner, W; Kahn, C M

    2014-02-01

    CONTEXT. Recent publications have graphically demonstrated a curvilinear relationship between measures of intelligence and blood lead levels at low concentrations (dose-response curves. METHODS. Random data based on varied distributions were constructed to simulate a previous study using a single, randomly generated covariate income (Inc) to demonstrate the impact of normally versus exponentially distributed data on the shape of the graph of intelligence quotient (IQ) versus blood lead. We also used an existing database of US blood lead levels and constructed a similar model of income and IQ using both assumptions of distribution for the intermediate variable income. RESULTS. When both lead and income are exponentially distributed, the graph of lead and IQ will be a curve. CONCLUSION. The apparent shape of a dose-response relationship from simulated epidemiological data is nonlinear when one variable and a covariate are exponentially distributed. A non-linear biological relationship should not be assumed and in fact may be the least likely explanation. The use of observational epidemiological data to discern a dose-response relationship between two variables may be misleading.

  17. Mathematical Modeling of Allelopathy. III. A Model for Curve-Fitting Allelochemical Dose Responses

    OpenAIRE

    Liu, Li; An, Min; Johnson, Ian R.; Lovett, John V.

    2003-01-01

    Bioassay techniques are often used to study the effects of allelochemicals on plant processes, and it is generally observed that the processes are stimulated at low allelochemical concentrations and inhibited as the concentrations increase. A simple empirical model is presented to analyze this type of response. The stimulation-inhibition properties of allelochemical-dose responses can be described by the parameters in the model. The indices, p% reductions, are calculated to assess the alleloc...

  18. Mathematical Modeling of Allelopathy. III. A Model for Curve-Fitting Allelochemical Dose Responses

    Science.gov (United States)

    Liu, De Li; An, Min; Johnson, Ian R.; Lovett, John V.

    2003-01-01

    Bioassay techniques are often used to study the effects of allelochemicals on plant processes, and it is generally observed that the processes are stimulated at low allelochemical concentrations and inhibited as the concentrations increase. A simple empirical model is presented to analyze this type of response. The stimulation-inhibition properties of allelochemical-dose responses can be described by the parameters in the model. The indices, p% reductions, are calculated to assess the allelochemical effects. The model is compared with experimental data for the response of lettuce seedling growth to Centaurepensin, the olfactory response of weevil larvae to α-terpineol, and the responses of annual ryegrass (Lolium multiflorum Lam.), creeping red fescue (Festuca rubra L., cv. Ensylva), Kentucky bluegrass (Poa pratensis L., cv. Kenblue), perennial ryegrass (L. perenne L., cv. Manhattan), and Rebel tall fescue (F. arundinacea Schreb) seedling growth to leachates of Rebel and Kentucky 31 tall fescue. The results show that the model gives a good description to observations and can be used to fit a wide range of dose responses. Assessments of the effects of leachates of Rebel and Kentucky 31 tall fescue clearly differentiate the properties of the allelopathic sources and the relative sensitivities of indicators such as the length of root and leaf. PMID:19330111

  19. Mathematical Modeling of Allelopathy. III. A Model for Curve-Fitting Allelochemical Dose Responses.

    Science.gov (United States)

    Liu, De Li; An, Min; Johnson, Ian R; Lovett, John V

    2003-01-01

    Bioassay techniques are often used to study the effects of allelochemicals on plant processes, and it is generally observed that the processes are stimulated at low allelochemical concentrations and inhibited as the concentrations increase. A simple empirical model is presented to analyze this type of response. The stimulation-inhibition properties of allelochemical-dose responses can be described by the parameters in the model. The indices, p% reductions, are calculated to assess the allelochemical effects. The model is compared with experimental data for the response of lettuce seedling growth to Centaurepensin, the olfactory response of weevil larvae to alpha-terpineol, and the responses of annual ryegrass (Lolium multiflorum Lam.), creeping red fescue (Festuca rubra L., cv. Ensylva), Kentucky bluegrass (Poa pratensis L., cv. Kenblue), perennial ryegrass (L. perenne L., cv. Manhattan), and Rebel tall fescue (F. arundinacea Schreb) seedling growth to leachates of Rebel and Kentucky 31 tall fescue. The results show that the model gives a good description to observations and can be used to fit a wide range of dose responses. Assessments of the effects of leachates of Rebel and Kentucky 31 tall fescue clearly differentiate the properties of the allelopathic sources and the relative sensitivities of indicators such as the length of root and leaf.

  20. Combining optimization methods with response spectra curve-fitting toward improved damping ratio estimation

    Science.gov (United States)

    Brewick, Patrick T.; Smyth, Andrew W.

    2016-12-01

    The authors have previously shown that many traditional approaches to operational modal analysis (OMA) struggle to properly identify the modal damping ratios for bridges under traffic loading due to the interference caused by the driving frequencies of the traffic loads. This paper presents a novel methodology for modal parameter estimation in OMA that overcomes the problems presented by driving frequencies and significantly improves the damping estimates. This methodology is based on finding the power spectral density (PSD) of a given modal coordinate, and then dividing the modal PSD into separate regions, left- and right-side spectra. The modal coordinates were found using a blind source separation (BSS) algorithm and a curve-fitting technique was developed that uses optimization to find the modal parameters that best fit each side spectra of the PSD. Specifically, a pattern-search optimization method was combined with a clustering analysis algorithm and together they were employed in a series of stages in order to improve the estimates of the modal damping ratios. This method was used to estimate the damping ratios from a simulated bridge model subjected to moving traffic loads. The results of this method were compared to other established OMA methods, such as Frequency Domain Decomposition (FDD) and BSS methods, and they were found to be more accurate and more reliable, even for modes that had their PSDs distorted or altered by driving frequencies.

  1. Dose-response curve for blood exposed to gamma-neutron mixed field by conventional cytogenetic method

    Energy Technology Data Exchange (ETDEWEB)

    Brandao, Jose Odinilson de C.; Souza, Priscilla L.G.; Santos, Joelan A.L.; Vilela, Eudice C.; Lima, Fabiana F., E-mail: jodinilson@cnen.gov.b, E-mail: fflima@cnen.gov.b, E-mail: jasantos@cnen.gov.b [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil); Calixto, Merilane S.; Santos, Neide, E-mail: santos_neide@yahoo.com.b [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Genetica

    2009-07-01

    There is increasing concern about airline crew members (about one million worldwide) are exposed to measurable neutrons doses. Historically, cytogenetic biodosimetry assays have been based on quantifying asymmetrical chromosome alterations (dicentrics, centric rings and acentric fragments) in mytogen-stimulated T-lymphocytes in their first mitosis after radiation exposure. Increased levels of chromosome damage in peripheral blood lymphocytes are a sensitive indicator of radiation exposure and they are routinely exploited for assessing radiation absorbed dose after accidental or occupational exposure. Since radiological accidents are not common, not all nations feel that it is economically justified to maintain biodosimetry competence. However, dependable access to biological dosimetry capabilities is completely critical in event of an accident. In this paper the dose-response curve was measured for the induction of chromosomal alterations in peripheral blood lymphocytes after chronic exposure in vitro to neutron-gamma mixes field. Blood was obtained from one healthy donor and exposed to two neutron-gamma mixed field from sources {sup 241}AmBe (20 Ci) at the Neutron Calibration Laboratory (NCL-CRCN/NE-PE-Brazil). The evaluated absorbed doses were 0.2 Gy; 1.0 Gy and 2.5 Gy. The dicentric chromosomes were observed at metaphase, following colcemid accumulation and 1000 well-spread metaphase figures were analyzed for the presence of dicentrics by two experienced scorers after painted by giemsa 5%. Our preliminary results showed a linear dependence between radiations absorbed dose and dicentric chromosomes frequencies. Dose-response curve described in this paper will contribute to the construction of calibration curve that will be used in our laboratory for biological dosimetry. (author)

  2. On-Sky Tests of an A/R Coated Silicon Grism on board NICS@TNG

    CERN Document Server

    Vitali, Fabrizio; Lorenzetti, Dario; Cianci, Elena; Ghinassi, Francesca; Harutyunyan, Avet; Antoniucci, Simone; Riverol, Carlos; Riverol, Luis

    2014-01-01

    We present the results of our project for the design and construction and on-sky test of silicon grisms. The fabrication of such devices is a complex and critical process involving litho-masking, anisotropic etching and direct bonding techniques. After the successful fabrication of the silicon grating, we have optimized the bonding of the grating onto the hypotenuse of a silicon prism to get the final prototype. After some critical phases during the experimentation a silicon grism with 363 grooves/mm and a blaze angle of 14 degrees has been eventually fabricated. The application of an A/R coating on both the surfaces has been the last step: this procedure is critical because of the groove geometry of the diffraction grating, whose performace might be compromised by the coating. Then, the grism was inserted in the filter wheel of the Near Infrared camera NICS, at the focal plane of the National Galileo Telescope (TNG), the 3.5 m Italian facility in the Canary Islands (E). The result of the on-sky tests are giv...

  3. Fundamental investigations of natural and laboratory generated SAR dose response curves for quartz OSL in the high dose range

    DEFF Research Database (Denmark)

    Timar-Gabor, Alida; Constantin, Daniela; Buylaert, Jan-Pieter

    2015-01-01

    SAR-OSL investigations on quartz from Romanian loess resulted in non concordant fine and coarse-grain ages for equivalent doses higher than ~100 Gy. The laboratory dose response for both grain sizes is well represented by a sum of two saturating exponential functions, fine and coarse grains chara...... equivalent dose of 2000e2500 Gy were found to be below the saturation level of the laboratory dose response curve for both grain sizes; this also applied to the luminescence signals measured after >5000 Gy given on top of natural doses. © 2015 Elsevier Ltd. All rights reserved....... characterised by D01 and D02 values of ~140 and ~1400 Gy and ~65 and ~650 Gy respectively. Pulsed OSL experiments confirmed that this behaviour is almost certainly inherent to quartz and not caused by contamination with another mineral. Natural doseeresponse curves do not follow the same pattern and enter...... saturation much earlier. Analysis of time resolved spectra indicated similar luminescence lifetimes for both fine and coarse quartz grains, and natural and laboratory generated OSL signals seem to use the same non-dosedependent recombination pathways. The natural signals of a sample with an expected...

  4. VizieR Online Data Catalog: Hubble Legacy Archive ACS grism data (Kuemmel+, 2011)

    Science.gov (United States)

    Kuemmel, M.; Rosati, P.; Fosbury, R.; Haase, J.; Hook, R. N.; Kuntschner, H.; Lombardi, M.; Micol, A.; Nilsson, K. K.; Stoehr, F.; Walsh, J. R.

    2011-09-01

    A public release of slitless spectra, obtained with ACS/WFC and the G800L grism, is presented. Spectra were automatically extracted in a uniform way from 153 archival fields (or "associations") distributed across the two Galactic caps, covering all observations to 2008. The ACS G800L grism provides a wavelength range of 0.55-1.00um, with a dispersion of 40Å/pixel and a resolution of ~80Å for point-like sources. The ACS G800L images and matched direct images were reduced with an automatic pipeline that handles all steps from archive retrieval, alignment and astrometric calibration, direct image combination, catalogue generation, spectral extraction and collection of metadata. The large number of extracted spectra (73,581) demanded automatic methods for quality control and an automated classification algorithm was trained on the visual inspection of several thousand spectra. The final sample of quality controlled spectra includes 47919 datasets (65% of the total number of extracted spectra) for 32149 unique objects, with a median iAB-band magnitude of 23.7, reaching 26.5 AB for the faintest objects. Each released dataset contains science-ready 1D and 2D spectra, as well as multi-band image cutouts of corresponding sources and a useful preview page summarising the direct and slitless data, astrometric and photometric parameters. This release is part of the continuing effort to enhance the content of the Hubble Legacy Archive (HLA) with highly processed data products which significantly facilitate the scientific exploitation of the Hubble data. In order to characterize the slitless spectra, emission-line flux and equivalent width sensitivity of the ACS data were compared with public ground-based spectra in the GOODS-South field. An example list of emission line galaxies with two or more identified lines is also included, covering the redshift range 0.2-4.6. Almost all redshift determinations outside of the GOODS fields are new. The scope of science projects possible

  5. Measurement of Photomultipier Plateau Curves and Single MIP response in the AD detector at ALICE

    CERN Document Server

    Sanchez Falero, Sebastian De Jesus

    2015-01-01

    The Alice Diffractive (AD) detector is a forward detector in the ALICE experiment at CERN. It is aimed to the triggering on diffractive events and extends the pseudorapidity coverage to about 4.9 < /n/ < 6.3. In this work, a PMT's efficiency plateau and single MIP response are measured using a replica of the detector's scintillator modules, electronic and data acquisition system and cosmic rays as particle source.

  6. Biphasic fluence-response curves for phytochrome-mediated kalanchoë seed germination : sensitization by gibberellic Acid.

    Science.gov (United States)

    Rethy, R; Dedonder, A; De Petter, E; Van Wiemeersch, L; Fredericq, H; De Greef, J; Steyaert, H; Stevens, H

    1987-01-01

    The fluence-response curves for the effect of two red pulses separated by 24 hours on the germination of Kalanchoe blossfeldiana Poelln. cv Vesuv seeds, incubated on gibberellic acid (GA(3)) are biphasic for suboptimal concentrations. The response in the low fluence range corresponds with a classical red/far-red reversible phytochrome mediated reaction. GA(3) induces an additional response in the very low fluence range, which is also phytochrome mediated. The sensitivity to phytochrome-far-red absorbing form (Pfr), however, is increased about 20,000-fold, so that even far-red fluences become saturating. Both in the very low and low fluence response range, the maximal responses induced by saturating fluences are modulated by the GA(3) concentration. GA(3) having no direct influence on the phytochrome phototransformations, alters the Pfr requirement and determines the responding seed population fraction in the very low and low fluence range. The effet of GA(3) appears to be on the transduction chain of the phytochrome signal.

  7. Leveraging 3D-HST Grism Redshifts to Quantify Photometric Redshift Performance

    CERN Document Server

    Bezanson, Rachel; Brammer, Gabriel B; van Dokkum, Pieter G; Franx, Marijn; Labbé, Ivo; Leja, Joel; Momcheva, Ivelina G; Nelson, Erica J; Quadri, Ryan F; Skelton, Rosalind E; Weiner, Benjamin J; Whitaker, Katherine E

    2015-01-01

    We present a study of photometric redshift accuracy in the 3D-HST photometric catalogs, using 3D-HST grism redshifts to quantify and dissect trends in redshift accuracy for galaxies brighter than $H_{F140W} 2$), dusty star-forming galaxies for which the scatter increases to $\\sim0.1(1+z)$. Although the overall photometric redshift accuracy for quiescent galaxies is better than for star-forming galaxies, scatter depends more strongly on magnitude and redshift than on galaxy type. We verify these trends using the redshift distributions of close pairs and extend the analysis to fainter objects, where photometric redshift errors further increase to $\\sim0.046(1+z)$ at $H_{F160W}=26$. We demonstrate that photometric redshift accuracy is strongly filter-dependent and quantify the contribution of multiple filter combinations. We evaluate the widths of redshift probability distribution functions and find that error estimates are underestimated by a factor of $\\sim1.1-1.6$, but that uniformly broadening the distributi...

  8. The ground calibrations of the WFC3/UVIS G280 grism

    Science.gov (United States)

    Kuntschner, H.; Bushouse, H.; Kümmel, M.; Walsh, J. R.

    2009-01-01

    Based on thermal vacuum tests (TV2; June - August 2007 and TV3; March/April 2008), the performance of the WFC3 UV G280 grism has been assessed. The locations of the different orders relative to exposures taken through a direct imaging filter are determined, trace and wavelength solutions are derived for a central position on each chip, and the absolute throughput of the different orders is quantified. Aperture corrections are given as a function of wavelength. Furthermore, we describe flat-field cubes that provide pixel-to-pixel information as a function of wavelength to an accuracy of about 2%. The +1st order is useful for scientific observations in the range ~190 to 500nm, however, the +2nd order spectrum is overlapping with the first order for wavelengths larger than about 390nm. For wavelengths above ~320nm, the 0th order, which shows a small dispersion, carries more power than the +1st order. Therefore, especially for red sources, the 0th order is prone to saturation effects. The trace and wavelength solutions show significant variations as a function of position within the field-of-view. However, the available ground calibrations are not sufficient to establish a full position-dependent calibration. Henceforth, the calibrations reported in this ISR can only be used to extract spectra of relatively isolated, blue targets placed at the central position on Chips 1 or 2.

  9. Disentangling AGN and Star Formation Activity at High Redshift Using Hubble Space Telescope Grism Spectroscopy

    CERN Document Server

    Bridge, Joanna S; Trump, Jonathan R; Gronwall, Caryl; Ciardullo, Robin; Fox, Derek B; Schneider, Donald P

    2016-01-01

    Differentiating between active galactic nuclei (AGN) activity and star formation in z ~ 2 galaxies is difficult because traditional methods, such as line ratio diagnostics, change with redshift while multi-wavelength methods (X-ray, radio, IR) are sensitive to only the brightest AGN. We have developed a new method for spatially resolving emission lines in HST/WFC3 G141 grism spectra and quantifying AGN activity through the spatial gradient of the [O III]/H$\\beta$ line ratio. Through detailed simulations, we show that our novel line-ratio gradient approach identifies ~ sim 40% more low-mass and obscured AGN than obtained by classical methods. Based on our simulations, we developed a relationship that maps stellar mass, star formation rate, and measured [O III]/H$\\beta$ gradient to AGN Eddington ratio. We apply our technique to previously studied stacked samples of galaxies at z ~2 and find that our results are consistent with these studies. Using this gradient method will also be able to inform other galaxy ev...

  10. Science with FORCAST, the mid-IR imager and grism spectrometer for SOFIA (Conference Presentation)

    Science.gov (United States)

    Helton, L. Andrew

    2016-09-01

    The Faint Object infraRed CAmera for the SOFIA Telescope (FORCAST) is a dual-channel mid-infrared camera and spectrograph sensitive from 5-40 µm. The Short Wave Camera (SWC) uses a Si:As blocked-impurity band (BIB) array optimized for λ BIB array is optimized for λ < 25 µm. Observations can be made through either of the two channels individually or, by use of a dichroic mirror, with both channels simultaneously across most of the range. Spectroscopy is also possible using a suite of four grisms, which provide coverage from 5-40 µm with a low spectral resolution of R = λ =Δλ 200. Since it's commissioning FORCAST has made a number of exciting observations, including the discovery of dust that survived the reverse shock in the supernova remnant Sgr A East, the identification of an asteroid belt analog surrounding ɛ Eridani, and some of the highest resolution mid-IR observations of the transient Galactic circumnuclear ring to date. Here I present a selection of recent SOFIA FORCAST observations and discuss their relevance to a variety of today's most pressing astronomical topics.

  11. Bending the curve: force health protection during the insertion phase of the Ebola outbreak response.

    Science.gov (United States)

    Bailey, Mark S; Beaton, K; Bowley, D; Eardley, W; Hunt, P; Johnson, S; Round, J; Tarmey, N T; Williams, A

    2016-06-01

    After >10 years of enduring operations in Iraq and Afghanistan, Defence Strategic Direction is returning to a contingency posture. As the first post-Afghanistan operation, in September 2014, a UK Joint Inter-Agency Task Force deployed to Sierra Leone in response to the Ebola virus disease (EVD) epidemic in West Africa. The aims were expanding treatment capacity, assisting with training and supporting host nation resilience. The insertion phase of this deployment created a unique set of challenges for force health protection. In addition to the considerable risk of tropical disease and trauma, deployed personnel faced the risks of working in an EVD epidemic. This report explores how deployed medical assets overcame the difficulties of mounting a short-notice contingent operation in a region of the world with inherent major climatic and health challenges.

  12. Testing of a spatial impulse response algorithm for double curved transducers

    DEFF Research Database (Denmark)

    Bæk, David; Jensen, Jørgen Arendt; Willatzen, Morten

    2010-01-01

    , and it is the objective of this work to validate an analyticalapproximation of the algorithm as an alternative solver for Field II. Twoapproximations of a SAA that efficiently finds the SIR for DCT have beenimplemented into a MATLAB and a C-code environment. The root mean square (RMS)error of calculating the SIR using......'sprinciple. This calculation method involves several summations, and it relies onexact phase calculation to avoid numerical noise in the response. A stableanalytical expression for the SIR would thus be beneficial to the Field IIsoftware as an alternative solver. A semi-analytic algorithm (SAA) has beendeveloped...... Field II and the C-implemented approximationare calculated relative to a high resolution solution obtained with MATLAB on aDCT, a linear concave, and a flat transducer. The computation time for solving apoint 400 times is also found. Calculations are performed at samplingfrequencies ranging from 100 MHz...

  13. Mutations induced in Tradescantia by small doses of X-rays and neutrons - Analysis of dose-response curves.

    Science.gov (United States)

    Sparrow, A. H.; Underbrink, A. G.; Rossi, H. H.

    1972-01-01

    Dose-response curves for pink somatic mutations in Tradescantia stamen hairs were analyzed after neutron and X-ray irradiation with doses ranging from a fraction of a rad to the region of saturation. The dose-effect relation for neutrons indicates a linear dependence from 0.01 to 8 rads; between 0.25 and 5 rads, a linear dependence is indicated for X-rays also. As a consequence the relative biological effectiveness reaches a constant value (about 50) at low doses. The observations are in good agreement with the predictions of the theory of dual radiation action and support its interpretation of the effects of radiation on higher organisms. The doubling dose of X-rays was found to be nearly 1 rad.

  14. How much is enough? Modulation of dose-response curve for steroid receptor-regulated gene expression by changing concentrations of transcription factor.

    Science.gov (United States)

    Simons, S Stoney

    2006-01-01

    The position of the dose-response curve for steroid-regulated gene expression determines how much variation in response will accompany the normal physiological changes in circulating steroid. Over the last several years, it has become clear that the concentration of steroid hormone required for half-maximal induction or repression by a given receptor-steroid complex, which is normally called the EC50, is not constant for all responsive genes. Thus, the position of the dose-response curve can change so that a single concentration of steroid produces very different percentages of maximal activity. This, in turn, allows for the differential expression of genes by a common steroid hormone concentration during development, differentiation, and homeostasis. Here we review the variety of factors that influence the EC50 and position of the dose-response curve for steroid hormone receptors, discuss what is known about the mechanisms, and highlight promising areas for future research.

  15. Inverse U-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulation.

    Science.gov (United States)

    Jahn, Klaus; Naessl, Andrea; Schneider, Erich; Strupp, Michael; Brandt, Thomas; Dieterich, Marianne

    2003-07-01

    To investigate age dependent changes we analysed torsional eye movement responses to binaural and monaural galvanic vestibular stimulation (GVS) in 57 healthy subjects (20-69 years old). GVS (1-3 mA) induced torsional eye movements consisting of static torsion toward the anode (amplitude 1-6 degrees ) and superimposed torsional nystagmus (slow phase velocity 0.5-3 degrees /s, quick phase amplitude 0.5-2 degrees, nystagmus frequency 0.75-1.5 s-1). Static ocular torsion and torsional nystagmus increased from the third to the sixth decade and decreased in older subjects, e.g. slow phase velocity increased from 1.5 degrees /s (20-29 years) to 2.9 degrees /s (50-59 years) and decreased to 2.5 degrees /s for the seventh decade (60-69 years). Thus, an inverse U-shaped curve was found for the dependence of torsional eye movement responses on age. All structures relevant for vestibular function degenerate with age, but at varying times. Since hair cell loss precedes those seen in the vestibular nerve and Scarpa's ganglion, the decrease in hair cell counts could be compensated for by increased sensitivity of afferent nerve fibres or central mechanisms. Increased sensitivity could thus maintain normal function despite reduced peripheral input. As GVS acts at the vestibular nerve (thereby bypassing the hair cells), electrical stimulation should be more efficient in subjects with the beginning of hair cell degeneration, as seen in our data up to the sixth decade. The degeneration of nerve fibres, ganglion cells and central neurons becomes evident at older ages. Thus, the compensatory increase in sensitivity breaks down and GVS-induced eye movements decline-a finding that is reflected by the inverse U-shaped curve for age dependency presented in this study.

  16. Results from Stacking Grism Spectra of Galaxies at 0.6 < z < 1.2 in the Probing Evolution And Reionization Survey (PEARS)

    Science.gov (United States)

    Joshi, Bhavin; Malhotra, Sangeeta; Windhorst, Rogier A.; PEARS Team, FIGS Team

    2016-06-01

    We present results from median stacking of low-resolution grism spectra for ~1700 galaxies at 0.6 ACS G800L grism survey in GOODS-N and GOODS-S. The visible and near-IR coverage of the grism, 6000A to 9500A, provides rest-frame visible wavelength coverage from ~3000A to ~6000A for the redshift range of our sample. We median stack galaxies of similar rest-frame u-r color and stellar mass by selecting them based on their location in our u-r color vs stellar mass diagram. The grism spectra are stacked in bins of 0.3 in u-r color and 0.5 dex in stellar mass over a range of 0.0 < u-r < 3.0 and 7.0 < log(M) [M_sol] < 11.5 with an average of ~30 galaxies per bin. We find that blue cloud galaxies typically show bluer continua, Balmer breaks and also show H-beta and [OIII] emission lines that are blended together due to the low-resolution of the grism. Red sequence galaxies typically show strong 4000A breaks and redder continua and, at lower significance, also the G-band and Mgb absorption features characteristic of late type stars. We also observe that green valley galaxies, which form ~6% of the total sample, typically show weaker 4000A breaks and relatively flatter continua at wavelengths redder than 4000A.

  17. Silent period to transcranial magnetic stimulation: construction and properties of stimulus-response curves in healthy volunteers.

    Science.gov (United States)

    Kimiskidis, V K; Papagiannopoulos, S; Sotirakoglou, K; Kazis, D A; Kazis, A; Mills, K R

    2005-05-01

    Silent period (SP) is widely used in transcranial magnetic stimulation studies. Methodologically, SP is usually elicited at stimulus intensities corresponding to a certain percentage of corticomotor threshold. Because this approach might lead to factitious SP changes, the present study was designed to develop, in a stepwise manner, a method for investigating SP independently of corticomotor threshold. First, stimulus-response (S-R) curves of SP against stimulus intensity (SI) were constructed and quantitatively described in healthy volunteers. Second, various methodological issues such as the optimum model for describing the relationship between SP duration and SI and the importance of the type of stimulating coil were addressed. Finally, the proposed method and a commonly used method (eliciting SPs at 130% MT SI) were directly compared for a group of epileptic patients for whom administration of oxcarbazepine resulted in significant corticomotor threshold elevation. Twenty-one subjects (eleven females, median age, 38 years) were studied. SPs were obtained with a figure-of-eight coil using a standardized procedure (recording, FDI). Pilot experiments indicated that at least four trials were required, at each intensity level, to estimate the mean SP duration within 10% of the true mean. Therefore, SPs were determined from the average of four trials with 5% increments from 5 to 100% maximum SI. In a second set of experiments, SPs were obtained for fifteen subjects using a circular coil. In a third set of experiments, eight epileptic patients were studied before and after administration of oxcarbazepine (mean dose 1553 mg, range 900-1800 mg). The S-R curves were fitted to a Boltzman function and to first-order to fourth-order polynomial and sigmoid functions. The Boltzman function described the data accurately (R2=0.947-0.990). In addition, direct comparison of the six models with an F-test proved the superiority of the first. The best-fit parameters of the reference

  18. Influences of membrane properties on phase response curve and synchronization stability in a model globus pallidus neuron.

    Science.gov (United States)

    Fujita, Tomohiro; Fukai, Tomoki; Kitano, Katsunori

    2012-06-01

    The activity patterns of the globus pallidus (GPe) and subthalamic nucleus (STN) are closely associated with motor function and dysfunction in the basal ganglia. In the pathological state caused by dopamine depletion, the STN-GPe network exhibits rhythmic synchronous activity accompanied by rebound bursts in the STN. Therefore, the mechanism of activity transition is a key to understand basal ganglia functions. As synchronization in GPe neurons could induce pathological STN rebound bursts, it is important to study how synchrony is generated in the GPe. To clarify this issue, we applied the phase-reduction technique to a conductance-based GPe neuronal model in order to derive the phase response curve (PRC) and interaction function between coupled GPe neurons. Using the PRC and interaction function, we studied how the steady-state activity of the GPe network depends on intrinsic membrane properties, varying ionic conductances on the membrane. We noted that a change in persistent sodium current, fast delayed rectifier Kv3 potassium current, M-type potassium current and small conductance calcium-dependent potassium current influenced the PRC shape and the steady state. The effect of those currents on the PRC shape could be attributed to extension of the firing period and reduction of the phase response immediately after an action potential. In particular, the slow potassium current arising from the M-type potassium and the SK current was responsible for the reduction of the phase response. These results suggest that the membrane property modulation controls synchronization/asynchronization in the GPe and the pathological pattern of STN-GPe activity.

  19. SPATIALLY RESOLVED HST GRISM SPECTROSCOPY OF A LENSED EMISSION LINE GALAXY AT z {approx} 1

    Energy Technology Data Exchange (ETDEWEB)

    Frye, Brenda L. [Steward Observatory, Department of Astronomy, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Hurley, Mairead [School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9 (Ireland); Bowen, David V. [Department of Astrophysical Sciences, Peyton Hall, Princeton University, Princeton, NJ 08540 (United States); Meurer, Gerhardt [International Centre for Radio Astronomy Research, The University of Western Australia M468, 35 Stirling Highway, Crawley, WA 6009 (Australia); Sharon, Keren [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States); Straughn, Amber [Astrophysics Science Division, Goddard Space Flight Center, Code 665, Greenbelt, MD 20771 (United States); Coe, Dan [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Broadhurst, Tom [Ikerbasque, Basque Foundation for Science, E-48011 Bilbao (Spain); Guhathakurta, Puragra, E-mail: bfrye@as.arizona.edu [UCO/Lick Observatory, Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States)

    2012-07-20

    We take advantage of gravitational lensing amplification by A1689 (z 0.187) to undertake the first space-based census of emission line galaxies (ELGs) in the field of a massive lensing cluster. Forty-three ELGs are identified to a flux of i{sub 775} = 27.3 via slitless grism spectroscopy. One ELG (at z = 0.7895) is very bright owing to lensing magnification by a factor of Almost-Equal-To 4.5. Several Balmer emission lines (ELs) detected from ground-based follow-up spectroscopy signal the onset of a major starburst for this low-mass galaxy (M{sub *} Almost-Equal-To 2 Multiplication-Sign 10{sup 9} M{sub Sun }) with a high specific star formation rate ( Almost-Equal-To 20 Gyr{sup -1}). From the blue ELs we measure a gas-phase oxygen abundance consistent with solar (12+log(O/H) = 8.8 {+-} 0.2). We break the continuous line-emitting region of this giant arc into seven {approx}1 kpc bins (intrinsic size) and measure a variety of metallicity-dependent line ratios. A weak trend of increasing metal fraction is seen toward the dynamical center of the galaxy. Interestingly, the metal line ratios in a region offset from the center by {approx}1 kpc have a placement on the blue H II region excitation diagram with f ([O III])/f (H{beta}) and f ([Ne III])/f (H{beta}) that can be fitted by an active galactic nucleus (AGN). This asymmetrical AGN-like behavior is interpreted as a product of shocks in the direction of the galaxy's extended tail, possibly instigated by a recent galaxy interaction.

  20. A sex-specific dose-response curve for testosterone: could excessive testosterone limit sexual interaction in women?

    Science.gov (United States)

    Krapf, Jill M; Simon, James A

    2017-04-01

    Testosterone treatment increases sexual desire and well-being in women with hypoactive sexual desire disorder; however, many studies have shown only modest benefits limited to moderate doses. Unlike men, available data indicate women show a bell-shaped dose-response curve for testosterone, wherein a threshold dosage of testosterone leads to desirable sexual function effects, but exceeding this threshold results in a lack of further positive sexual effects or may have a negative impact. Emotional and physical side-effects of excess testosterone, including aggression and virilization, may counteract the modest benefits on sexual interaction, providing a possible explanation for a threshold dose of testosterone in women. In this commentary, we will review and critically analyze data supporting a curvilinear dose-response relationship between testosterone treatment and sexual activity in women with low libido, and also explore possible explanations for this observed relationship. Understanding optimal dosing of testosterone unique to women may bring us one step closer to overcoming regulatory barriers in treating female sexual dysfunction.

  1. A new approach for determining phase response curves reveals that Purkinje cells can act as perfect integrators.

    Directory of Open Access Journals (Sweden)

    Elena Phoka

    2010-04-01

    Full Text Available Cerebellar Purkinje cells display complex intrinsic dynamics. They fire spontaneously, exhibit bistability, and via mutual network interactions are involved in the generation of high frequency oscillations and travelling waves of activity. To probe the dynamical properties of Purkinje cells we measured their phase response curves (PRCs. PRCs quantify the change in spike phase caused by a stimulus as a function of its temporal position within the interspike interval, and are widely used to predict neuronal responses to more complex stimulus patterns. Significant variability in the interspike interval during spontaneous firing can lead to PRCs with a low signal-to-noise ratio, requiring averaging over thousands of trials. We show using electrophysiological experiments and simulations that the PRC calculated in the traditional way by sampling the interspike interval with brief current pulses is biased. We introduce a corrected approach for calculating PRCs which eliminates this bias. Using our new approach, we show that Purkinje cell PRCs change qualitatively depending on the firing frequency of the cell. At high firing rates, Purkinje cells exhibit single-peaked, or monophasic PRCs. Surprisingly, at low firing rates, Purkinje cell PRCs are largely independent of phase, resembling PRCs of ideal non-leaky integrate-and-fire neurons. These results indicate that Purkinje cells can act as perfect integrators at low firing rates, and that the integration mode of Purkinje cells depends on their firing rate.

  2. Implementation of a dose-response curve for γ-radiation in the Portuguese population by use of the chromosomal aberration assay.

    Science.gov (United States)

    Martins, V; Antunes, A C; Monteiro Gil, O

    2013-01-20

    An in vitro dose-response curve following exposure to γ-radiation was determined at the IST/ITN, by use of the chromosomal aberration assay. This is the first study of this kind carried out among the Portuguese population. Un-irradiated and γ-irradiated peripheral blood lymphocytes from 16 healthy donors were cultured. A total of 22,395 metaphases were analyzed for frequency and distribution of dicentrics and centric rings, as a function of the radiation dose. The dose-response data for dicentrics and dicentrics plus centric rings were fitted by use of a linear-quadratic model: Y(dic)=(0.0011±0.0006)+(0.0105±0.0035)D+(0.0480±0.0019)D(2) and Y(dic+rings)=(0.0011±0.0006)+(0.0095±0.0036)D+(0.0536±0.0020)D(2). Also, calibration curves related to age and gender were determined, but no significant differences were found. Following the establishment of the dose-response curves, a validation experiment was carried out with three individuals. Real and estimated doses, obtained with the dose-response curves, were in agreement. These results give us confidence to apply both dose-response calibration curves in future biological dosimetry requirements.

  3. Searching for AGN Signatures in HST WFC3/IR Grism Spectra of Clumpy Galaxies at 0.5 < z < 2

    Science.gov (United States)

    Han, Anna; Schawinski, K.; Simmons, B. D.; Urry, C. M.; Glikman, E.; Bamford, S.; Lintott, C.

    2012-01-01

    The recent discovery of a "clumpy” galaxy with three actively growing black holes in separate clumps at z = 1.35 raises the possibility of supermassive black holes (SMBHs) forming in situ within gas clouds at later epochs than previously expected. We carry out a systematic search for 0.5 science project. We then analyze the grism data of individual clumps within each galaxy to characterize the probability of SMBHs forming and growing in the clumps of forming disk galaxies at 0.5 < z < 2.

  4. A Predictor--Corrector Method for the 3--DIM Restoration of GRISM and Slitless Spectra; Tools for NICMOS and STIS.

    Science.gov (United States)

    Caulet, A.

    1996-12-01

    Grism or slitless spectroscopy can provide spectroscopic information of all objects in the detector field of view (FOV). Because of overlapping and object crowding, in practice, only stellar objects are exploited; most extended objects are discarded, except when some obvious emission line can be isolated. The goal of this work has been to produce an efficient code that restores the full capability of image--spectroscopy. A set of data consists of grism (or slitless) images of a given field observed at 4 different roll--angles, and for each roll-angle, an image for field identification. The IDL code is based on a predictor--corrector iterative method. The method is used to restore the true spectra of extended sources appropriate to spectroscopic observations with the new HST instruments (NICMOS, STIS). The FOV is the Hubble Deep Field. First, each pixel is given an input ``true" spectrum. Simulations of 2--DIM grism images for 4 different roll-angles are made (DATA). Then, the code calculates the first spectral data cube (3--DIM MODEL, images for each sampled wavelength) by combining the 2--DIM DATA for each point in the sky for all wavelengths. This data cube is used to simulate new 2--DIM grism images (PRED). The image ratios PRED/DATA for the 4 roll-angles are combined and used to correct the previous 3--DIM MODEL. And so on, until convergence (via chi2). Appropriate masking and normalization are made; this ensures that no false object appears. With 4 roll-angles, the true spectra are restored in about 30 iterations, i.e. 5 hours on a Sparc 20/502 running Solaris 2.4. For each iteration, error pixel maps are calculated to assess how well the DATA can be predicted. The final error maps are attached to the final 3--DIM restored cube and can be used for further data analysis. The code does not use (de)convolution. The PSFs can be measured from the final cube for each wavelength, from stars in the field. 2--DIM spatial deconvolution can be made after restoration

  5. Efficacy of atomoxetine in adult attention-Deficit/Hyperactivity Disorder: a drug-placebo response curve analysis

    Directory of Open Access Journals (Sweden)

    Reimherr Fred

    2005-10-01

    Full Text Available Abstract Background The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit/hyperactivity disorder (ADHD among adults by using drug-placebo response curve methods. Methods We analyzed data from two double-blind, placebo-controlled, parallel design studies of adult patients (Study I, N = 280; Study II, N = 256 with DSM-IV-defined ADHD who were recruited by referral and advertising. Subjects were randomized to 10 weeks of treatment with atomoxetine or placebo, and were assessed with the Conners Adult ADHD Rating Scales and the Clinical Global Impression of ADHD Severity scale before and after treatment. Results Those treated with atomoxetine were more likely to show a reduction in ADHD symptoms than those receiving placebo. Across all measures, the likelihood that an atomoxetine-treated subject improved to a greater extent than a placebo-treated subject was approximately 0.60. Furthermore, atomoxetine prevented worsening of most symptom classes. Conclusion From these findings, we conclude that atomoxetine is an effective treatment for ADHD among adults when evaluated using several criteria.

  6. Optimal design for hetero-associative memory: hippocampal CA1 phase response curve and spike-timing-dependent plasticity.

    Directory of Open Access Journals (Sweden)

    Ryota Miyata

    Full Text Available Recently reported experimental findings suggest that the hippocampal CA1 network stores spatio-temporal spike patterns and retrieves temporally reversed and spread-out patterns. In this paper, we explore the idea that the properties of the neural interactions and the synaptic plasticity rule in the CA1 network enable it to function as a hetero-associative memory recalling such reversed and spread-out spike patterns. In line with Lengyel's speculation (Lengyel et al., 2005, we firstly derive optimally designed spike-timing-dependent plasticity (STDP rules that are matched to neural interactions formalized in terms of phase response curves (PRCs for performing the hetero-associative memory function. By maximizing object functions formulated in terms of mutual information for evaluating memory retrieval performance, we search for STDP window functions that are optimal for retrieval of normal and doubly spread-out patterns under the constraint that the PRCs are those of CA1 pyramidal neurons. The system, which can retrieve normal and doubly spread-out patterns, can also retrieve reversed patterns with the same quality. Finally, we demonstrate that purposely designed STDP window functions qualitatively conform to typical ones found in CA1 pyramidal neurons.

  7. Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs.

    Science.gov (United States)

    Shen, Lin; Peterson, Susan; Sedaghat, Ahmad R; McMahon, Moira A; Callender, Marc; Zhang, Haili; Zhou, Yan; Pitt, Eleanor; Anderson, Karen S; Acosta, Edward P; Siliciano, Robert F

    2008-07-01

    Highly active antiretroviral therapy (HAART) can control HIV-1 replication, but suboptimal treatment allows for the evolution of resistance and rebound viremia. A comparative measure of antiviral activity under clinically relevant conditions would guide drug development and the selection of regimens that maximally suppress replication. Here we show that current measures of antiviral activity, including IC(50) and inhibitory quotient, neglect a key dimension, the dose-response curve slope. Using infectivity assays with wide dynamic range, we show that this slope has noteworthy effects on antiviral activity. Slope values are class specific for antiviral drugs and define intrinsic limitations on antiviral activity for some classes. Nucleoside reverse transcriptase inhibitors and integrase inhibitors have slopes of approximately 1, characteristic of noncooperative reactions, whereas non-nucleoside reverse transcriptase inhibitors, protease inhibitors and fusion inhibitors unexpectedly show slopes >1. Instantaneous inhibitory potential (IIP), the log reduction in single-round infectivity at clinical drug concentrations, is strongly influenced by slope and varies by >8 logs for anti-HIV drugs. IIP provides a more accurate measure of antiviral activity and in general correlates with clinical outcomes. Only agents with slopes >1 achieve high-level inhibition of single-round infectivity, a finding with profound implications for drug and vaccine development.

  8. Hubble Space Telescope WFC3 Grism Spectroscopy and Imaging of a Growing Compact Galaxy at z=1.9

    CERN Document Server

    van Dokkum, Pieter G

    2010-01-01

    We present HST/WFC3 grism spectroscopy of the brightest galaxy at z>1.5 in the GOODS-South WFC3 Early Release Science grism pointing, covering the wavelength range 0.9-1.7 micron. The spectrum is of remarkable quality and shows the redshifted Balmer lines Hbeta, Hgamma, and Hdelta in absorption at z=1.902, correcting previous erroneous redshift measurements from the rest-frame UV. The average rest-frame equivalent width of the Balmer lines is 8+-1 Angstrom, which can be produced by a post-starburst stellar population with a luminosity-weighted age of ~0.5 Gyr. The M/L ratio inferred from the spectrum implies a stellar mass of ~4x10^11 Msun. We determine the morphology of the galaxy from a deep WFC3 F160W image. Similar to other massive galaxies at z~2 the galaxy is compact, with an effective radius of 2.1+-0.3 kpc. Although most of the light is in a compact core, the galaxy has two red, smooth spiral arms that appear to be tidally-induced. The spatially-resolved spectroscopy demonstrates that the center of th...

  9. Estimation of a Ramsay-Curve Item Response Theory Model by the Metropolis-Hastings Robbins-Monro Algorithm. CRESST Report 834

    Science.gov (United States)

    Monroe, Scott; Cai, Li

    2013-01-01

    In Ramsay curve item response theory (RC-IRT, Woods & Thissen, 2006) modeling, the shape of the latent trait distribution is estimated simultaneously with the item parameters. In its original implementation, RC-IRT is estimated via Bock and Aitkin's (1981) EM algorithm, which yields maximum marginal likelihood estimates. This method, however,…

  10. Cytogenetics dosimetry: dose-response curve for low doses of X-ray; Dosimetria citogenetica: curva dosis-respuesta para bajas dosis de rayos-X

    Energy Technology Data Exchange (ETDEWEB)

    Lara, Virginia E. Noval; Pineda Bolivar, William R.; Riano, Victor M. Pabon, E-mail: venovall.15@hotmail.com, E-mail: wrpineda@misena.edu.co, E-mail: vmpabonr@udistrital.edu.co [Universidad Distrital Francisco Jose de Caldas (UD), Bogota (Colombia). Grupo de Investigacion en Ciencia y Tecnologia Nuclear; Ureana, Cecilia Crane, E-mail: cecicrane@yahoo.com [Instituto Nacional de Salud (INS), Bogota (Colombia). Laboratorio de Genetica

    2013-07-01

    The purpose of this study was to conduct a preliminary study for the standardization in the future, the dose-response curve for low doses of X-rays, through the analysis of in vitro cultures of peripheral blood samples of 3 men and 3 women occupationally not exposed to artificial sources of ionizing radiation, age 18-40 years, where possible nonsmokers.

  11. Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human

    NARCIS (Netherlands)

    Strikwold, M.; Spenkelink, B.; Woutersen, R.A.; Rietjens, I.M.C.M.; Punt, A.

    2013-01-01

    In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can

  12. Lateral-torsional response of base-isolated buildings with curved surface sliding system subjected to near-fault earthquakes

    Science.gov (United States)

    Mazza, Fabio

    2017-08-01

    The curved surface sliding (CSS) system is one of the most in-demand techniques for the seismic isolation of buildings; yet there are still important aspects of its behaviour that need further attention. The CSS system presents variation of friction coefficient, depending on the sliding velocity of the CSS bearings, while friction force and lateral stiffness during the sliding phase are proportional to the axial load. Lateral-torsional response needs to be better understood for base-isolated structures located in near-fault areas, where fling-step and forward-directivity effects can produce long-period (horizontal) velocity pulses. To analyse these aspects, a six-storey reinforced concrete (r.c.) office framed building, with an L-shaped plan and setbacks in elevation, is designed assuming three values of the radius of curvature for the CSS system. Seven in-plan distributions of dynamic-fast friction coefficient for the CSS bearings, ranging from a constant value for all isolators to a different value for each, are considered in the case of low- and medium-type friction properties. The seismic analysis of the test structures is carried out considering an elastic-linear behaviour of the superstructure, while a nonlinear force-displacement law of the CSS bearings is considered in the horizontal direction, depending on sliding velocity and axial load. Given the lack of knowledge of the horizontal direction at which near-fault ground motions occur, the maximum torsional effects and residual displacements are evaluated with reference to different incidence angles, while the orientation of the strongest observed pulses is considered to obtain average values.

  13. A rat model of unilateral hindpaw burn injury: slowly developing rightwards shift of the morphine dose-response curve.

    Science.gov (United States)

    Wang, Shuxing; Lim, Grewo; Yang, Liling; Zeng, Qing; Sung, Backil; Jeevendra Martyn, J A; Mao, Jianren

    2005-07-01

    Management of pain after burn injury is an unresolved clinical issue. In a rat model of hindpaw burn injury, we examined the effects of systemic morphine on nociceptive behaviors following injury. Injury was induced by immersing the dorsal part of one hindpaw into a hot water bath (85 degrees C) for 4, 7, or 12 s under pentobarbital anesthesia. Mechanical allodynia to von Frey filament stimulation and thermal hyperalgesia to radiant heat were assessed. Burn injury induced by the 12-s (but not 4-, or 7-s) hot water immersion resulted in reliable and lasting mechanical allodynia and thermal hyperalgesia evident by day 1. In addition, there was an upregulation of protein kinase Cgamma and a progressive downregulation of mu-opioid receptors within the spinal cord dorsal horn ipsilateral to injury as revealed by immunohistochemistry and Western blot. In both injured and sham rats, the anti-nociceptive effects of subcutaneous morphine were examined on post-injury days 7 and 14. While the morphine AD50 dose was comparable on day 7 between burn (1.61 mg/kg) and control (1.7 mg/kg) rats, the morphine dose-response curve was shifted to the right in burn-injured rats (4.6 mg/kg) on post-injury day 14 as compared with both the injured rats on post-injury day 7 and sham rats on day 14 (1.72 mg/kg). These data indicate that hindpaw burn injury reliably produces persistent mechanical allodynia and thermal hyperalgesia and that the reduced efficacy of morphine anti-nociception in chronic burn injury may be in part due to a downregulation of spinal mu-opioid receptors.

  14. Analysis test of understanding of vectors with the three-parameter logistic model of item response theory and item response curves technique

    Science.gov (United States)

    Rakkapao, Suttida; Prasitpong, Singha; Arayathanitkul, Kwan

    2016-12-01

    This study investigated the multiple-choice test of understanding of vectors (TUV), by applying item response theory (IRT). The difficulty, discriminatory, and guessing parameters of the TUV items were fit with the three-parameter logistic model of IRT, using the parscale program. The TUV ability is an ability parameter, here estimated assuming unidimensionality and local independence. Moreover, all distractors of the TUV were analyzed from item response curves (IRC) that represent simplified IRT. Data were gathered on 2392 science and engineering freshmen, from three universities in Thailand. The results revealed IRT analysis to be useful in assessing the test since its item parameters are independent of the ability parameters. The IRT framework reveals item-level information, and indicates appropriate ability ranges for the test. Moreover, the IRC analysis can be used to assess the effectiveness of the test's distractors. Both IRT and IRC approaches reveal test characteristics beyond those revealed by the classical analysis methods of tests. Test developers can apply these methods to diagnose and evaluate the features of items at various ability levels of test takers.

  15. Dose-Finding when the Target Dose Is on a Plateau of a Dose-Response Curve: Comparison of Fully Sequential Designs

    OpenAIRE

    Ivanova, Anastasia; Xiao, Changfu

    2013-01-01

    Consider the problem of estimating a dose with a certain response rate. Many multistage dose-finding designs for this problem were originally developed for oncology studies where the mean dose-response is strictly increasing in dose. In non-oncology Phase II dose-finding studies the dose-response curve often plateaus in the range of interest and there are several doses with the mean response equal to the target. In this case it is usually of interest to find the lowest of these doses since hi...

  16. Construction of a cytogenetic dose-response curve for low-dose range gamma-irradiation in human peripheral blood lymphocytes using three-color FISH.

    Science.gov (United States)

    Suto, Yumiko; Akiyama, Miho; Noda, Takashi; Hirai, Momoki

    2015-12-01

    In order to estimate biological doses after low-dose ionizing radiation exposure, fluorescence in situ hybridization (FISH) using three differentially colored chromosome painting probes was employed to detect exchange-type chromosome aberrations. A reference dose response curve was constructed using blood samples from a female donor whose lymphocytes consistently exhibited a low frequency of cells at the second mitosis under routine culture conditions. Aberration yields were studied for a total of about 155 thousand metaphases obtained from seven dose-points of gamma irradiations (0, 50, 100, 150, 200, 250 and 300mGy). In situ hybridization was performed using commercially available painting probes for chromosomes 1, 2 and 4. With the aid of an automated image-capturing method, exchange-type aberrations involving painted chromosomes were detected with considerable accuracy and speed. The results on the exchange-type aberrations (dicentrics plus translocations) at the seven dose-points showed a good fit to the linear-quadratic model (y=0.0023+0.0015x+0.0819x(2), P=0.83). A blind test proved the reproducibility of the reference dose-response relationship. In the control experiments using blood samples from another donor, the estimated doses calculated on the basis of the present reference curve were proved to be in good agreement with the actual physical doses applied. The present dose-response curve may serve as a means to assess the individual differences in cytogenetical radio-sensitivities.

  17. Interpretation of the margin of exposure for genotoxic carcinogens - elicitation of expert knowledge about the form of the dose response curve at human relevant exposures.

    Science.gov (United States)

    Boobis, Alan; Flari, Villie; Gosling, John Paul; Hart, Andy; Craig, Peter; Rushton, Lesley; Idahosa-Taylor, Ehi

    2013-07-01

    The general approach to risk assessment of genotoxic carcinogens has been to advise reduction of exposure to "as low as reasonably achievable/practicable" (ALARA/P). However, whilst this remains the preferred risk management option, it does not provide guidance on the urgency or extent of risk management actions necessary. To address this, the "Margin of Exposure" (MOE) approach has been proposed. The MOE is the ratio between the point of departure for carcinogenesis and estimated human exposure. However, interpretation of the MOE requires implicit or explicit consideration of the shape of the dose-response curve at human relevant exposures. In a structured elicitation exercise, we captured expert opinion on available scientific evidence for low dose-response relationships for genotoxic carcinogens. This allowed assessment of: available evidence for the nature of dose-response relationships at human relevant exposures; the generality of judgments about such dose-response relationships; uncertainties affecting judgments on the nature of such dose-response relationships; and whether this last should differ for different classes of genotoxic carcinogens. Elicitation results reflected the variability in experts' views on the form of the dose-response curve for low dose exposure and major sources of uncertainty affecting the assumption of a linear relationship.

  18. Dose finding when the target dose is on a plateau of a dose-response curve: comparison of fully sequential designs.

    Science.gov (United States)

    Ivanova, Anastasia; Xiao, Changfu

    2013-01-01

    Consider the problem of estimating a dose with a certain response rate. Many multistage dose-finding designs for this problem were originally developed for oncology studies where the mean dose-response is strictly increasing in dose. In non-oncology phase II dose-finding studies, the dose-response curve often plateaus in the range of interest, and there are several doses with the mean response equal to the target. In this case, it is usually of interest to find the lowest of these doses because higher doses might have higher adverse event rates. It is often desirable to compare the response rate at the estimated target dose with a placebo and/or active control. We investigate which of the several known dose-finding methods developed for oncology phase I trials is the most suitable when the dose-response curve plateaus. Some of the designs tend to spread the allocation among the doses on the plateau. Others, such as the continual reassessment method and the t-statistic design, concentrate allocation at one of the doses with the t-statistic design selecting the lowest dose on the plateau more frequently.

  19. Dose response curve of induction of MN in lymphocytes for energies Cs-137; Curva dosis respuesta de induccion de micronucleos en linfocitos para las energias Cs-137

    Energy Technology Data Exchange (ETDEWEB)

    Serna Berna, A.; Alcaraz, M.; Acevedo, C.; Vicente, V.; Fuente, I. de la; Canteras, M.

    2006-07-01

    The determination of the dose-response curve is a crucial step to use the Micronucleus assay in Lymphocytes as a biological dosimeters. The most widely used fitting function is the linear-quadratic function. The coefficients are fitted by calibration data provided by irradiations of blood from healthy donors. In our case we performed the calibration curve corresponding to gamma radiation from Cesium-137 (660 keV). Doses ranged from 0 to 16 Gy. The fitting procedure used was the iteratively re weighted least square algorithm implemented in a Matlab routine. The results of the analysis of our data show that the dose-effect curve does not follow a linear-quadratic curve at high radiation doses, diminishing the quadratic parameters as dose increases. This can be interpreted as a micronucleus saturation effect beyond a certain dose level. We conclude that the MN assay with lymphocytes can be well characterized as a biological dosimeters up to a maximum dose of 4.5 Gy. (Author)

  20. Outliers on the dose-response curve: how to minimize this problem using therapeutic drug monitoring, an underutilized tool in psychiatry.

    Science.gov (United States)

    Preskorn, Sheldon H

    2010-05-01

    This column continues the discussion of outliers on the dose-response curve begun in earlier columns. It focuses on therapeutic drug monitoring (TDM) as an underutilized tool in psychiatry to minimize this problem. The scientific rationale for dose adjustment based on TDM is presented and its efficiency is contrasted with dose adjustment based on clinical assessment of response. In current practice, the use of TDM with psychiatric drugs is generally restricted to drugs with narrow therapeutic windows or drugs imported into psychiatry from neurology where TDM is more commonly used. Examples of each of these types of drugs are cited.

  1. Effects of fluticasone propionate on arachidonic acid metabolites in BAL-fluid and methacholine dose-response curves in non-smoking atopic asthmatics

    Directory of Open Access Journals (Sweden)

    S. E. Overbeek

    1996-01-01

    Full Text Available Hyperresponsiveness of the airways to nonspecific stimuli is a characteristic feature of asthma. Airway responsiveness is usually characterized in terms of the position and shape of the dose–response curve to methacholine (MDR. In the study we have investigated the influence of fluticasone propionate (FP, a topically active glucocorticoid, on arachidonic acid (AA metabolites in broncho-alveolar lavage (BAL fluid (i.e. TxB2, PGE2, PGD2, 6kPGF1α and LTC4 on the one hand and MDR curves on the other hand. The effect of FP was studied in a randomized, double-blind, placebo-controlled design in 33 stable nonsmoking asthmatics; 16 patients received FP (500 μg b.i.d. whereas 17 patients were treated with placebo. We found that the forced expiratory volume in 1s (FEV1 % predicted increased, the log2PC20 methacholine increased and the plateau value (% fall in FEV1 decreased after a 12 week treatment period. No changes in AA-metabolites could be determined after treatment except for PGD2 which decreased nearly significantly (p = 0.058 within the FP treated group, whereas the change of PGD2 differed significantly (p = 0.05 in the FP treated group from placebo. The levels of the other AA metabolites (i.e. TxB2, PGE2, 6kPGF1α and LTC4 remained unchanged after treatment and were not significantly different from the placebo group. Our results support the hypothesis that although FP strongly influences the position, the shape and also the maximum response plateau of the MDR curve, this effect is not mainly achieved by influence on the level of AA metabolites. Other pro-inflammatory factors may be of more importance for the shape of the MDR curve. It is suggested that these pro-inflammatory factors are downregulated by FP.

  2. Divergent selection for shape of growth curve in Japanese quail. 1. Responses in growth parameters and food conversion.

    Science.gov (United States)

    Hyánková, L; Knízetová, H; Dĕdková, L; Hort, J

    2001-12-01

    1. HG and LG quail lines selected for high and low relative weight gain between 11 and 28 d of age (RG11-28), respectively, and an unselected C line were compared. Mature body weight of both selected lines was held at that of the C line. Progeny of generation 6 were used for analysis. 2. Divergent selection for RG11-28 brought about opposite changes in the growth rates shortly after hatching. 3. Parameters of the Richards function were used to describe the growth curve. The largest differences between HG and LG lines occurred in age (t+) and body weight (y+) at the inflection point of the growth curve (on average for both sexes 28% and 20%, respectively). For HG quail, the parameter t+ was 5 d later than that for LG quail (18.6 vs 14.1 d for males and 20.6 vs 15.6 d for females, respectively), and consequently the parameter y+ was greater (90.3 vs 84.0 g for males and 104.5 vs 96.1 g for females, respectively). The shape of the growth curve expressed by the y+/A ratio was substantialy different for HG and LG quail (44.8% vs 39.6% for males and 43.5% vs 36.8% for females, respectively). 4. The food/gain ratios for the fattening period (3 to 35 d of age) were 3.21, 3.47 and 3.34 for the HG, LG and C lines, respectively. The HG quail started to utilise food more efficiently than the LG quail as early as 10 to 14 d, that is, at the age when their relative growth rate first became greater. 5. The relative deviations of the HG and LG lines from the C line are discussed.

  3. Establishment of Dose-response Curves for Dicentrics and Premature Chromosome Condensation for Radiological Emergency Preparedness in Thailand

    Science.gov (United States)

    Rungsimaphorn, Benchawan; Rerkamnuaychoke, Budsaba; Sudprasert, Wanwisa

    2016-01-01

    The in vitro dose calibration curves using conventional biological dosimetry – dicentric chromosome assay (DCA) and premature chromosome condensation (PCC) assay – were performed for the first time in Thailand for reconstruction of radiation dose in the exposed individuals. The peripheral blood lymphocyte samples from healthy donors were irradiated with 137Cs source at a dose rate of 0.652 Gy/min to doses of 0.1, 0.25, 0.5, 0.75, 1, 2, 3, 4, and 5 Gy for DCA technique, and 5, 10, 15, 20, and 25 Gy for PCC technique. The blood samples were cultured and processed following the standard procedure as prescribed in the International Atomic Energy Agency report with slight modifications. The yield of dicentrics with dose from at least 1000 metaphases or 100 dicentrics was fitted to a linear quadratic model using Chromosome Aberration Calculation Software (CABAS, version 2.0) whereas those of PCC rings with dose from 100 rings was fitted to a linear quadratic equation at doses from 0 to 15 Gy. These curves will be useful for in vitro dose reconstruction and can support the preparedness for overexposure to radiation among public or occupational workers and eventual radiological accident in Thailand. PMID:28217284

  4. Mysteries of LiF TLD response following high ionisation density irradiation: nanodosimetry and track structure theory, dose response and glow curve shapes.

    Science.gov (United States)

    Horowitz, Y; Fuks, E; Datz, H; Oster, L; Livingstone, J; Rosenfeld, A

    2011-06-01

    Three outstanding effects of ionisation density on the thermoluminescence (TL) mechanisms giving rise to the glow peaks of LiF:Mg,Ti (TLD-100) are currently under investigation: (1) the dependence of the heavy charged particle (HCP) relative efficiency with increasing ionisation density and the effectiveness of its modelling by track structure theory (TST), (2) the behaviour of the TL efficiency, f(D), as a function of photon energy and dose. These studies are intended to promote the development of a firm theoretical basis for the evaluation of relative TL efficiencies to assist in their application in mixed radiation fields. And (3) the shape of composite peak 5 in the glow curve for various HCP types and energies and following high-dose electron irradiation, i.e. the ratio of the intensity of peak 5a to peak 5. Peak 5a is a low-temperature satellite of peak 5 arising from electron-hole capture in a spatially correlated trapping centre/luminescent centre (TC/LC) complex that has been suggested to possess a potential as a solid-state nanodosemeter due to the preferential electron/hole population of the TC/LC at high ionisation density. It is concluded that (1) the predictions of TST are very strongly dependent on the choice of photon energy used in the determination of f(D); (2) modified TST employing calculated values of f(D) at 2 keV is in agreement with 5-MeV alpha particle experimental results for composite peak 5 but underestimates the 1.5-MeV proton relative efficiencies. Both the proton and alpha particle relative TL efficiencies of the high-temperature TL (HTTL) peaks 7 and 8 are underestimated by an order of magnitude suggesting that the HTTL efficiencies are affected by other factors in addition to radial electron dose; (3) the dose-response supralinearity of peaks 7 and 8 change rapidly with photon energy: this behaviour is explained in the framework of the unified interaction model as due to a very strong dependence on photon energy of the relative

  5. Hα Star Formation Rates for z>1 Galaxy Clusters in the IRAC Shallow Cluster Survey Using WFC3 IR Grism Spectroscopy

    Science.gov (United States)

    Zeimann, Gregory; Stanford, A.; Brodwin, M.; Dey, A.; Stern, D.; Gonzalez, A.

    2011-05-01

    We present new HST WFC3 grism data for 17 z>1 galaxy clusters in the IRAC Shallow Cluster Survey (ISCS). Using the G141 grism (λ = 1.10 - 1.65 μm, 46.5 A/pixel), we identified ˜5-15 new cluster members in each cluster candidate with a visual inspection of emission line galaxies in the reduced 1-d and 2-d spectral extractions. Given the redshift range of the cluster candidates and the wavelength coverage of the G141 grism, the emission line most identified was the blended Hα+NII. Correlations found in the literature between the EW of Hα+NII and the line ratio of NII to Hα were used to deblend the two fluxes. Hα emission was used as an indicator of star formation. Our program is sensitive to an unobscured star formation rate of 4 M⊙ / Year for z=1.5 and a nominal 1:4 ratio of NII to Hα. Concurrent MIPS 24μm data allows for the comparison of different SFR tracers. Whenever possible, we also use the ratio of Hβ/Hα to estimate dust obscuration and correct the SFRs. This dataset allows the study of a wide-range of star formation rates in dense cluster cores during the peak epoch of galaxy formation.

  6. A CANDELS WFC3 Grism Study of Emission-Line Galaxies at z~2: A Mix of Nuclear Activity and Low-Metallicity Star Formation

    CERN Document Server

    Trump, Jonathan R; Scarlata, Claudia; Kocevski, Dale D; Bell, Eric F; McGrath, Elizabeth J; Koo, David C; Faber, S M; Laird, Elise S; Mozena, Mark; Rangel, Cyprian; Yan, Renbin; Yesuf, Hassen; Atek, Hakim; Dickinson, Mark; Donley, Jennifer L; Dunlop, James S; Ferguson, Henry C; Finkelstein, Steven L; Grogin, Norman A; Hathi, Nimish P; Juneau, Stephanie; Kartaltepe, Jeyhan S; Koekemoer, Anton M; Nandra, Kirpal; Newman, Jeffrey A; Rodney, Steven A; Straughn, Amber N; Teplitz, Harry I

    2011-01-01

    We present Hubble Space Telescope Wide Field Camera 3 slitless grism spectroscopy of 28 emission-line galaxies at z~2, in the GOODS-S region of the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS). The high sensitivity of these grism observations, with >5-sigma detections of emission lines to f > 2.5x10^{-18} erg/s/cm^2, means that the galaxies in the sample are typically ~7 times less massive (median M_* = 10^{9.5} M_sun) than previously studied z~2 emission-line galaxies. Despite their lower mass, the galaxies have OIII/Hb ratios which are very similar to previously studied z~2 galaxies and much higher than the typical emission-line ratios of local galaxies. The WFC3 grism allows for unique studies of spatial gradients in emission lines, and we stack the two-dimensional spectra of the galaxies for this purpose. In the stacked data the OIII emission line is more spatially concentrated than the Hb emission line with 98.1 confidence. We additionally stack the X-ray data (all sources are...

  7. Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life

    Directory of Open Access Journals (Sweden)

    Antonio W. Zuardi

    2017-05-01

    Full Text Available The purpose of this study was to investigate whether the anxiolytic effect of cannabidiol (CBD in humans follows the same pattern of an inverted U-shaped dose-effect curve observed in many animal studies. Sixty healthy subjects of both sexes aged between 18 and 35 years were randomly assigned to five groups that received placebo, clonazepam (1 mg, and CBD (100, 300, and 900 mg. The subjects were underwent a test of public speaking in a real situation (TPSRS where each subject had to speak in front of a group formed by the remaining participants. Each subject completed the anxiety and sedation factors of the Visual Analog Mood Scale and had their blood pressure and heart rate recorded. These measures were obtained in five experimental sessions with 12 volunteers each. Each session had four steps at the following times (minutes after administration of the drug/placebo, as time 0: -5 (baseline, 80 (pre-test, 153 (speech, and 216 (post-speech. Repeated-measures analyses of variance showed that the TPSRS increased the subjective measures of anxiety, heart rate, and blood pressure. Student-Newman-Keuls test comparisons among the groups in each phase showed significant attenuation in anxiety scores relative to the placebo group in the group treated with clonazepam during the speech phase, and in the clonazepam and CBD 300 mg groups in the post-speech phase. Clonazepam was more sedative than CBD 300 and 900 mg and induced a smaller increase in systolic and diastolic blood pressure than CBD 300 mg. The results confirmed that the acute administration of CBD induced anxiolytic effects with a dose-dependent inverted U-shaped curve in healthy subjects, since the subjective anxiety measures were reduced with CBD 300 mg, but not with CBD 100 and 900 mg, in the post-speech phase.

  8. Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life.

    Science.gov (United States)

    Zuardi, Antonio W; Rodrigues, Natália P; Silva, Angélica L; Bernardo, Sandra A; Hallak, Jaime E C; Guimarães, Francisco S; Crippa, José A S

    2017-01-01

    The purpose of this study was to investigate whether the anxiolytic effect of cannabidiol (CBD) in humans follows the same pattern of an inverted U-shaped dose-effect curve observed in many animal studies. Sixty healthy subjects of both sexes aged between 18 and 35 years were randomly assigned to five groups that received placebo, clonazepam (1 mg), and CBD (100, 300, and 900 mg). The subjects were underwent a test of public speaking in a real situation (TPSRS) where each subject had to speak in front of a group formed by the remaining participants. Each subject completed the anxiety and sedation factors of the Visual Analog Mood Scale and had their blood pressure and heart rate recorded. These measures were obtained in five experimental sessions with 12 volunteers each. Each session had four steps at the following times (minutes) after administration of the drug/placebo, as time 0: -5 (baseline), 80 (pre-test), 153 (speech), and 216 (post-speech). Repeated-measures analyses of variance showed that the TPSRS increased the subjective measures of anxiety, heart rate, and blood pressure. Student-Newman-Keuls test comparisons among the groups in each phase showed significant attenuation in anxiety scores relative to the placebo group in the group treated with clonazepam during the speech phase, and in the clonazepam and CBD 300 mg groups in the post-speech phase. Clonazepam was more sedative than CBD 300 and 900 mg and induced a smaller increase in systolic and diastolic blood pressure than CBD 300 mg. The results confirmed that the acute administration of CBD induced anxiolytic effects with a dose-dependent inverted U-shaped curve in healthy subjects, since the subjective anxiety measures were reduced with CBD 300 mg, but not with CBD 100 and 900 mg, in the post-speech phase.

  9. HST Grism Confirmation of Two $z \\sim 2$ Structures from the Clusters Around Radio-Loud AGN (CARLA) Survey

    CERN Document Server

    Noirot, Gaël; De Breuck, Carlos; Wylezalek, Dominika; Galametz, Audrey; Stern, Daniel; Mei, Simona; Brodwin, Mark; Cooke, Elizabeth A; Gonzalez, Anthony H; Hatch, Nina A; Rettura, Alessandro; Stanford, Spencer Adam

    2016-01-01

    Using HST slitless grism data, we report the spectroscopic confirmation of two distant structures at $z \\sim 2$ associated with powerful high-redshift radio-loud AGN. These rich structures, likely (forming) clusters, are among the most distant currently known and were identified on the basis of Spitzer/IRAC [3.6] - [4.5] color. We spectroscopically confirm 9 members in the field of MRC 2036-254, comprising eight star-forming galaxies and the targeted radio galaxy. The median redshift is $z = 2.000$. We spectroscopically confirm 10 members in the field of B3 0756+406, comprising eight star-forming galaxies and two AGN, including the targeted radio-loud quasar. The median redshift is $z = 1.986$. All confirmed members are within 500 kpc (1 arcmin) of the targeted AGN. We derive median (mean) star-formation rates of $\\sim 35~M_{\\odot}\\rm ~ yr^{-1}$ ($\\sim 50~M_{\\odot}\\rm ~ yr^{-1}$) for the confirmed star-forming members of both structures based on their [OIII]$\\lambda5007$ luminosities, and estimate average gal...

  10. WRECKING THE CURVE: ALTERED FUNCTIONAL RESPONSE OF TETRAGONEURIA (ODONATA: CORDULIIDAE) NAIADS INFECTED WITH METACERCARIAE OF HAEMATOLOECHUS FLOEDAE.

    Science.gov (United States)

    Leaphart, James C; Zelmer, Derek A

    2017-01-24

    The ubiquity of host-parasite interactions and their potential for substantial representation, in terms of overall biomass, within ecosystems suggests that parasites have the capacity to influence energy flow within an ecosystem. While the influence of certain parasites on prey behavior has been well-documented, parasites could also exert an influence on ecosystem dynamics by influencing predator feeding behavior. The functional response of Tetragoneuria naiads was characterized by presenting naiads with varying abundances of Daphnia magna, after which a subset of the naiads were exposed to cercariae of Haematoloechus floedae, and the feeding trials repeated for both the control and exposed odonates. A type II functional response was chosen as an appropriate model for comparison. An indicator variable approach to nonlinear regression of the functional response data indicated that infected odonate naiads spent significantly more time foraging than they did prior to infection, whereas there was no significant change in the functional response of the control naiads. Infected odonates also had a slower rate of growth. These results imply a metabolic cost to infection of Tetragoneuria naiads by H. floedae that might is associated with the encapsulating response to the metacercariae that was observed in infected naiads.

  11. Equivalent intraperitoneal doses of ibuprofen supplemented in drinking water or in diet: a behavioral and biochemical assay using antinociceptive and thromboxane inhibitory dose–response curves in mice

    Directory of Open Access Journals (Sweden)

    Raghda A.M. Salama

    2016-07-01

    Full Text Available Background. Ibuprofen is used chronically in different animal models of inflammation by administration in drinking water or in diet due to its short half-life. Though this practice has been used for years, ibuprofen doses were never assayed against parenteral dose–response curves. This study aims at identifying the equivalent intraperitoneal (i.p. doses of ibuprofen, when it is administered in drinking water or in diet. Methods. Bioassays were performed using formalin test and incisional pain model for antinociceptive efficacy and serum TXB2 for eicosanoid inhibitory activity. The dose–response curve of i.p. administered ibuprofen was constructed for each test using 50, 75, 100 and 200 mg/kg body weight (b.w.. The dose–response curves were constructed of phase 2a of the formalin test (the most sensitive phase to COX inhibitory agents, the area under the ‘change in mechanical threshold’-time curve in the incisional pain model and serum TXB2 levels. The assayed ibuprofen concentrations administered in drinking water were 0.2, 0.35, 0.6 mg/ml and those administered in diet were 82, 263, 375 mg/kg diet. Results. The 3 concentrations applied in drinking water lay between 73.6 and 85.5 mg/kg b.w., i.p., in case of the formalin test; between 58.9 and 77.8 mg/kg b.w., i.p., in case of the incisional pain model; and between 71.8 and 125.8 mg/kg b.w., i.p., in case of serum TXB2 levels. The 3 concentrations administered in diet lay between 67.6 and 83.8 mg/kg b.w., i.p., in case of the formalin test; between 52.7 and 68.6 mg/kg b.w., i.p., in case of the incisional pain model; and between 63.6 and 92.5 mg/kg b.w., i.p., in case of serum TXB2 levels. Discussion. The increment in pharmacological effects of different doses of continuously administered ibuprofen in drinking water or diet do not parallel those of i.p. administered ibuprofen. It is therefore difficult to assume the equivalent parenteral daily doses based on mathematical calculations.

  12. Equivalent intraperitoneal doses of ibuprofen supplemented in drinking water or in diet: a behavioral and biochemical assay using antinociceptive and thromboxane inhibitory dose-response curves in mice.

    Science.gov (United States)

    Salama, Raghda A M; El Gayar, Nesreen H; Georgy, Sonia S; Hamza, May

    2016-01-01

    Background. Ibuprofen is used chronically in different animal models of inflammation by administration in drinking water or in diet due to its short half-life. Though this practice has been used for years, ibuprofen doses were never assayed against parenteral dose-response curves. This study aims at identifying the equivalent intraperitoneal (i.p.) doses of ibuprofen, when it is administered in drinking water or in diet. Methods. Bioassays were performed using formalin test and incisional pain model for antinociceptive efficacy and serum TXB2 for eicosanoid inhibitory activity. The dose-response curve of i.p. administered ibuprofen was constructed for each test using 50, 75, 100 and 200 mg/kg body weight (b.w.). The dose-response curves were constructed of phase 2a of the formalin test (the most sensitive phase to COX inhibitory agents), the area under the 'change in mechanical threshold'-time curve in the incisional pain model and serum TXB2 levels. The assayed ibuprofen concentrations administered in drinking water were 0.2, 0.35, 0.6 mg/ml and those administered in diet were 82, 263, 375 mg/kg diet. Results. The 3 concentrations applied in drinking water lay between 73.6 and 85.5 mg/kg b.w., i.p., in case of the formalin test; between 58.9 and 77.8 mg/kg b.w., i.p., in case of the incisional pain model; and between 71.8 and 125.8 mg/kg b.w., i.p., in case of serum TXB2 levels. The 3 concentrations administered in diet lay between 67.6 and 83.8 mg/kg b.w., i.p., in case of the formalin test; between 52.7 and 68.6 mg/kg b.w., i.p., in case of the incisional pain model; and between 63.6 and 92.5 mg/kg b.w., i.p., in case of serum TXB2 levels. Discussion. The increment in pharmacological effects of different doses of continuously administered ibuprofen in drinking water or diet do not parallel those of i.p. administered ibuprofen. It is therefore difficult to assume the equivalent parenteral daily doses based on mathematical calculations.

  13. Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Wyrobek, A. J.; Manohar, C. F.; Nelson, D. O.; Furtado, M. R.; Bhattacharya, M. S.; Marchetti, F.; Coleman, M.A.

    2011-04-18

    We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblastoid (HL) cells from two unrelated individuals were exposed to graded doses of radiation spanning the range of 1-10 cGy were analyzed by transcriptome profiling, qPCR and bioinformatics, in comparison to sham irradiated samples. A set of {approx}80 genes showed consistent responses in both cell lines; these genes were associated with homeostasis mechanisms (e.g., membrane signaling, molecule transport), subcellular locations (e.g., Golgi, and endoplasmic reticulum), and involved diverse signal transduction pathways. The majority of radiation-modulated genes had plateau-like responses across 1-10 cGy, some with suggestive evidence that transcription was modulated at doses below 1 cGy. MYC, FOS and TP53 were the major network nodes of the low-dose response in HL cells. Comparison our low dose expression findings in HL cells with those of prior studies in mouse brain after whole body exposure, in human keratinocyte cultures, and in endothelial cells cultures, indicates that certain components of the low dose radiation response are broadly conserved across cell types and tissues, independent of proliferation status.

  14. Fundamental investigations of natural and laboratory generated SAR dose response curves for quartz OSL in the high dose range

    DEFF Research Database (Denmark)

    Timar-Gabor, Alida; Constantin, Daniela; Buylaert, Jan-Pieter;

    2015-01-01

    SAR-OSL investigations on quartz from Romanian loess resulted in non concordant fine and coarse-grain ages for equivalent doses higher than ~100 Gy. The laboratory dose response for both grain sizes is well represented by a sum of two saturating exponential functions, fine and coarse grains chara...

  15. Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams

    CERN Document Server

    Brown, Thomas A D; Alvarez, Diane; Matthews, Kenneth L; Ham, Kyungmin; Dugas, Joseph P; 10.1118/1.4767770

    2012-01-01

    This work investigates the dose-response curves of GAFCHROMIC EBT, EBT2, and EBT3 radiochromic films using synchrotron-produced monochromatic x-ray beams. EBT2 film is being utilized for dose verification in photoactivated Auger electron therapy at the Louisiana State University CAMD synchrotron facility. Monochromatic beams of 25, 30, and 35 keV were generated on the tomography beamline at CAMD. Ion chamber depth-dose measurements were used to determine the dose delivered to films irradiated at depths from 0.7 to 8.5 cm in a 10x10x10-cm3 PMMA phantom. AAPM TG-61 protocol was applied to convert measured ionization into dose. Films were digitized using an Epson 1680 Professional flatbed scanner and analyzed using the net optical density (NOD) derived from the red channel. A dose-response curve was obtained at 35 keV for EBT film, and at 25, 30, and 35 keV for EBT2 and EBT3 films. Calibrations of films for 4 MV x-rays were obtained for comparison using a radiotherapy accelerator at Mary Bird Perkins Cancer Cent...

  16. The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.

    Science.gov (United States)

    Louisse, Jochem; de Jong, Esther; van de Sandt, Johannes J M; Blaauboer, Bas J; Woutersen, Ruud A; Piersma, Aldert H; Rietjens, Ivonne M C M; Verwei, Miriam

    2010-12-01

    At present, regulatory assessment of systemic toxicity is almost solely carried out using animal models. The European Commission's REACH legislation stimulates the use of animal-free approaches to obtain information on the toxicity of chemicals. In vitro toxicity tests provide in vitro concentration-response curves for specific target cells, whereas in vivo dose-response curves are regularly used for human risk assessment. The present study shows an approach to predict in vivo dose-response curves for developmental toxicity by combining in vitro toxicity data and in silico kinetic modeling. A physiologically based kinetic (PBK) model was developed, describing the kinetics of four glycol ethers and their embryotoxic alkoxyacetic acid metabolites in rat and man. In vitro toxicity data of these metabolites derived in the embryonic stem cell test were used as input in the PBK model to extrapolate in vitro concentration-response curves to predicted in vivo dose-response curves for developmental toxicity of the parent glycol ethers in rat and man. The predicted dose-response curves for rat were found to be in concordance with the embryotoxic dose levels measured in reported in vivo rat studies. Therefore, predicted dose-response curves for rat could be used to set a point of departure for deriving safe exposure limits in human risk assessment. Combining the in vitro toxicity data with a human PBK model allows the prediction of dose-response curves for human developmental toxicity. This approach could therefore provide a means to reduce the need for animal testing in human risk assessment practices.

  17. Establishing cytogenetic biodosimetry laboratory in Saudi Arabia and producing preliminary calibration curve of dicentric chromosomes as biomarker for medical dose estimation in response to radiation emergencies.

    Science.gov (United States)

    Al-Hadyan, Khaled; Elewisy, Sara; Moftah, Belal; Shoukri, Mohamed; Alzahrany, Awad; Alsbeih, Ghazi

    2014-12-01

    In cases of public or occupational radiation overexposure and eventual radiological accidents, it is important to provide dose assessment, medical triage, diagnoses and treatment to victims. Cytogenetic bio-dosimetry based on scoring of dicentric chromosomal aberrations assay (DCA) is the "gold standard" biotechnology technique for estimating medically relevant radiation doses. Under the auspices of the National Science, Technology and Innovation Plan in Saudi Arabia, we have set up a biodosimetry laboratory and produced a national standard dose-response calibration curve for DCA, pre-required to estimate the doses received. For this, the basic cytogenetic DCA technique needed to be established. Peripheral blood lymphocytes were collected from four healthy volunteers and irradiated with radiation doses between 0 and 5 Gy of 320 keV X-rays. Then, lymphocytes were PHA stimulated, Colcemid division arrested and stained cytogenetic slides were prepared. The Metafer4 system (MetaSystem) was used for automatic and manually assisted metaphase finding and scoring of dicentric chromosomes. Results were fit to the linear-quadratic dose-effect model according to the IAEA EPR-Biodosimetry-2011 report. The resulting manually assisted dose-response calibration curve (Y = 0.0017 + 0.026 × D + 0.081 × D(2)) was in the range of those described in other populations. Although the automated scoring over-and-under estimates DCA at low (2 Gy) doses, respectively, it showed potential for use in triage mode to segregate between victims with potential risk to develop acute radiotoxicity syndromes. In conclusion, we have successfully established the first biodosimetry laboratory in the region and have produced a preliminary national dose-response calibration curve. The laboratory can now contribute to the national preparedness plan in response to eventual radiation emergencies in addition to providing information for decision makers and public health officials who assess the

  18. Response curves of the surface modules of the Pierre Auger Observatory and the contribution of the hadronic component to the total signal of extensive showers

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Marcio Ap.; Chinellato, J.A. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Inst. de Fisica

    2011-07-01

    Full text: At large distances from the shower's core, is generally said that the electromagnetic and muonic components are responsible for most of the signal detected and the contribution of hadrons is irrelevant. In fact, looking at the events generated by the simulations of showers, we see an average number of hadrons which is small compared to other components. On the other hand, the important factor to be considered is the fraction of energy they carry. Geant4 full simulations of shower particles interacting in the surface module are very time consuming. To overcome this difficulty, we produced a set of response curves that can replace the corresponding full simulations. To include albedo phenomena, we include a soil layer as a new target for hadronic interactions, with the detailed treatment of hadron interactions available in Geant4 tool kit. The response curves for each particle type were obtained with full runs of Geant4 in the new setup. We will present this parametrization, which reduce the processing time by factors larger than 1000 times. These response curves were implemented in the tool kit Offline, developed by the collaboration to simulate/reconstruct the development of air showers. The Geant4 class corresponding to the surface module was replaced by our parametrization, while the rest of the simulation chain remained unchanged. The main focus of this work are the interactions of the hadronic component, in the tank and in the soil target below the tank. Those were obtained with the new setup and compared to the results from the original version of Offline. To assess the contribution of hadrons, we also studied the contribution of other components under the same conditions, so we can to obtain always the effect of hadronic interactions compared with the other components. We make a comparison between the energy reconstructed by the original Offline (with no changes) and the Offline with the implementation of our parameterization. We can infer the

  19. Cardiovascular effects of indapamide in hypertensive patients with or without renal failure. A dose-response curve.

    Science.gov (United States)

    Leenen, F H; Smith, D L; Farkas, R M; Boer, W H; Reeves, R A; Marquez-Julio, A

    1988-01-29

    Fifteen patients with mild-to-moderate hypertension (10 with normal and five with decreased renal function) were studied after treatment with placebo and low (1 mg), intermediate (2.5 mg), and high (5.0 mg per day) doses of indapamide, each for four weeks. Six patients--five with normal renal function--were classified as nonresponders (decrease in diastolic blood pressure less than 5 mm Hg). The remaining nine patients had dose-related decreases in blood pressure. Patients with or without renal failure showed similar decreases in blood pressure. Blood pressure reduction was associated with a significant decrease in cardiac index in the responders at the highest dose, related to a decrease in left ventricular end-diastolic dimension and stroke volume, whereas heart rate did not increase. This apparent decrease in venous return was associated with a significant decrease in body weight but not plasma volume in the responders. Indapamide did not change plasma norepinephrine levels, but decreased pressor responsiveness to exogenous norepinephrine. Responders had lower initial plasma renin activity and a smaller absolute increase in plasma renin activity while receiving indapamide, whereas angiotensin II pressor responsiveness was decreased more. The results presented indicate that the blood pressure lowering effect of indapamide in the present patient population is observed with or without renal failure and is associated with a decrease in pressor reactivity. In nonresponders, compensatory mechanisms (e.g., renin) may negate the antihypertensive effect of indapamide.

  20. A New Drug Combinatory Effect Prediction Algorithm on the Cancer Cell Based on Gene Expression and Dose-Response Curve.

    Science.gov (United States)

    Goswami, C Pankaj; Cheng, L; Alexander, P S; Singal, A; Li, L

    2015-02-01

    Gene expression data before and after treatment with an individual drug and the IC20 of dose-response data were utilized to predict two drugs' interaction effects on a diffuse large B-cell lymphoma (DLBCL) cancer cell. A novel drug interaction scoring algorithm was developed to account for either synergistic or antagonistic effects between drug combinations. Different core gene selection schemes were investigated, which included the whole gene set, the drug-sensitive gene set, the drug-sensitive minus drug-resistant gene set, and the known drug target gene set. The prediction scores were compared with the observed drug interaction data at 6, 12, and 24 hours with a probability concordance (PC) index. The test result shows the concordance between observed and predicted drug interaction ranking reaches a PC index of 0.605. The scoring reliability and efficiency was further confirmed in five drug interaction studies published in the GEO database.

  1. UV effects on the primary productivity of picophytoplankton: biological weighting functions and exposure response curves of Synechococcus

    Science.gov (United States)

    Neale, P. J.; Pritchard, A. L.; Ihnacik, R.

    2014-05-01

    A model that predicts UV effects on marine primary productivity using a biological weighting function (BWF) coupled to the photosynthesis-irradiance response (BWF/P-E model) has been implemented for two strains of the picoplanktonic cyanobacteria Synechococcus, WH7803 and WH8102, which were grown at two irradiances (77 and 174 μmol m-2 s-1 photosynthetically available radiation (PAR)) and two temperatures (20 and 26 °C). The model was fit using photosynthesis measured in a polychromatic incubator with 12 long-pass filter configurations with 50% wavelength cutoffs ranging from 291 to 408 nm, giving an effective wavelength range of 280-400 nm. Examination of photosynthetic response vs. weighted exposure revealed that repair rate progressively increases at low exposure but reaches a maximum rate above a threshold exposure ("Emax"). Adding Emax as a parameter to the BWF/P-E model provided a significantly better fit to Synechococcus data than the existing "E" or "T" models. Sensitivity to UV inhibition varied with growth conditions for both strains, but this was mediated mainly by variations in Emax for WH8102 while both the BWF and Emax changed for WH7803. Higher growth temperature was associated with a considerable reduction in sensitivity, consistent with an important role of repair in regulating sensitivity to UV. Based on nominal water column conditions (noon, solstice, 23° latitude, "blue" water), the BWFEmax/P-E model estimates that UV + PAR exposure inhibits Synechococcus photosynthesis from 78 to 91% at 1 m, and integrated productivity to 150 m 17-29% relative to predicted rates in the absence of inhibition.

  2. Human Chorionic Gonadotropin (hCG) Regression Curve for Predicting Response to EMA/CO (Etoposide, Methotrexate, Actinomycin D, Cyclophosphamide and Vincristine) Regimen in Gestational Trophoblastic Neoplasia.

    Science.gov (United States)

    Rattanaburi, Athithan; Boonyapipat, Sathana; Supasinth, Yuthasak

    2015-01-01

    An hCG regression curve has been used to predict the natural history and response to chemotherapy in gestational trophoblastic disease. We constructed hCG regression curves in high-risk gestational trophoblastic neoplasia (GTN) treated with EMA/CO and identified an optimal hCG level to detect EMA/CO resistance in GTN. Eighty-one women with GTN treated with EMA/CO were classified as primary high-risk GTN (n=65) and single agent-resistance GTN (n=16). The hCG levels prior to each course of chemotherapy were plotted in the 10th, 50th, and 90th percentiles to construct the hCG regression curves. Diagnostic performance was evaluated for an optimal cut-off value. The median hCG levels were 264,482 mIU/mL mIU/mL and 495.5 mIU/mL mIU/mL for primary high-risk GTN and single agent-resistance GTN, respectively. The 50th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 4th and the 2nd course of chemotherapy, respectively. The 90th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 9th and the 2nd course of chemotherapy, respectively. The hCG level of ≥118.6 mIU/mL mIU/mL at the 5thcourse of EMA/CO predicted the EMA/CO resistance in primary high-risk GTN patients with a sensitivity of 85.7% and a specificity of 100%. EMA/CO resistance in primary high-risk GTN can be predicted by using an hCG regression curve in combination with the cut-off value of 118.6 mIU/mL at the 5thcourse of chemotherapy.

  3. A CANDELS WFC3 GRISM STUDY OF EMISSION-LINE GALAXIES AT z {approx} 2: A MIX OF NUCLEAR ACTIVITY AND LOW-METALLICITY STAR FORMATION

    Energy Technology Data Exchange (ETDEWEB)

    Trump, Jonathan R.; Kocevski, Dale D.; McGrath, Elizabeth J.; Koo, David C.; Faber, S. M.; Mozena, Mark; Yesuf, Hassen [University of California Observatories/Lick Observatory, Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Weiner, Benjamin J. [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Scarlata, Claudia [Astronomy Department, University of Minnesota, Minneapolis, MN 55455 (United States); Bell, Eric F. [Department of Astronomy, University of Michigan, 500 Church St., Ann Arbor, MI 48109 (United States); Laird, Elise S.; Rangel, Cyprian [Astrophysics Group, Imperial College London, Blackett Laboratory, Prince Consort Road, London SW7 2AZ (United Kingdom); Yan Renbin [Department of Physics, Center for Cosmology and Particle Physics, New York University, New York, NY 10003 (United States); Atek, Hakim [Spitzer Science Center, Caltech, Pasadena, CA 91125 (United States); Dickinson, Mark [National Optical Astronomical Observatories, Tucson, AZ 85719 (United States); Donley, Jennifer L.; Ferguson, Henry C.; Grogin, Norman A. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Dunlop, James S. [Institute for Astronomy, University of Edinburgh, Royal Observatory, Edinburgh, EH9 3HJ (United Kingdom); Finkelstein, Steven L. [Department of Physics and Astronomy, Texas A and M University, 4242 TAMU, College Station, TX 77843 (United States); and others

    2011-12-20

    We present Hubble Space Telescope Wide Field Camera 3 (WFC3) slitless grism spectroscopy of 28 emission-line galaxies at z {approx} 2, in the GOODS-S region of the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey. The high sensitivity of these grism observations, with >1{sigma} detections of emission lines to f > 2.5 Multiplication-Sign 10{sup -18} erg s{sup -1} cm{sup -2}, means that the galaxies in the sample are typically {approx}7 times less massive (median M{sub *} = 10{sup 9.5} M{sub Sun }) than previously studied z {approx} 2 emission-line galaxies. Despite their lower mass, the galaxies have [O III]/H{beta} ratios which are very similar to previously studied z {approx} 2 galaxies and much higher than the typical emission-line ratios of local galaxies. The WFC3 grism allows for unique studies of spatial gradients in emission lines, and we stack the two-dimensional spectra of the galaxies for this purpose. In the stacked data the [O III] emission line is more spatially concentrated than the H{beta} emission line with 98.1% confidence. We additionally stack the X-ray data (all sources are individually undetected), and find that the average L{sub [OIII]}/L{sub 0.5-10keV} ratio is intermediate between typical z {approx} 0 obscured active galaxies and star-forming galaxies. Together the compactness of the stacked [O III] spatial profile and the stacked X-ray data suggest that at least some of these low-mass, low-metallicity galaxies harbor weak active galactic nuclei.

  4. A CANDELS WFC3 Grism Study of Emission-Line Galaxies at Z approximates 2: A mix of Nuclear Activity and Low-Metallicity Star Formation

    Science.gov (United States)

    Trump, Jonathan R.; Weiner, Benjamin J.; Scarlata, Claudia; Kocevski, Dale D.; Bell, Eric F.; McGrath, Elizabeth J.; Koo, David C.; Faber, S. M.; Laird, Elise S.; Mozena, Mark; Rangel, Cyprian; Yan, Renbin; Yesuf, Hassen; Atek, Hakim; Dickinson, Mark; Donley, Jennifer L.; Dunlop, James S.; Ferguson, Henry C.; Finkelstein, Steven L.; Grogin, Norman A.; Hathi, Nimish P.; Juneau, Stephanie; Kartaltepe, Jeyhan S.; Koekemoer, Anton M.; Nandra, Kirpal

    2011-01-01

    We present Hubble Space Telescope Wide Field Camera 3 slitless grism spectroscopy of 28 emission-line galaxies at z approximates 2, in the GOODS-S region of the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS). The high sensitivity of these grism observations, with > 5-sigma detections of emission lines to f > 2.5 X 10(exp -18( erg/s/ square cm, means that the galaxies in the sample are typically approximately 7 times less massive (median M(star). = 10(exp 9.5)M(solar)) than previously studied z approximates 2 emission-line galaxies. Despite their lower mass, the galaxies have [O-III]/H-Beta ratios which are very similar to previously studied z approximates 2 galaxies and much higher than the typical emission-line ratios of local galaxies. The WFC3 grism allows for unique studies of spatial gradients in emission lines, and we stack the two-dimensional spectra of the galaxies for this purpose. In the stacked data the [O-III] emission line is more spatially concentrated than the H-Beta emission line with 98.1% confidence. We additionally stack the X-ray data (all sources are individually undetected), and find that the average L(sub [O-III])/L(sub 0.5.10keV) ratio is intermediate between typical z approximates 0 obscured active galaxies and star-forming galaxies. Together the compactness of the stacked [O-III] spatial profile and the stacked X-ray data suggest that at least some of these low-mass, low-metallicity galaxies harbor weak active galactic nuclei.

  5. Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human.

    Science.gov (United States)

    Strikwold, Marije; Spenkelink, Bert; Woutersen, Ruud A; Rietjens, Ivonne M C M; Punt, Ans

    2013-09-01

    In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like the no observed adverse effect level (NOAEL) or the 95 % lower confidence limit of the benchmark dose (BMDL). To overcome this constraint, the present study combined in vitro data with a physiologically based kinetic (PBK) model applying reverse dosimetry. To this end, embryotoxicity of phenol was evaluated in vitro using the embryonic stem cell test (EST), revealing a concentration-dependent inhibition of differentiation into beating cardiomyocytes. In addition, a PBK model was developed on the basis of in vitro and in silico data and data available from the literature only. After evaluating the PBK model performance, effective concentrations (ECx) obtained with the EST served as an input for in vivo plasma concentrations in the PBK model. Applying PBK-based reverse dosimetry provided in vivo external effective dose levels (EDx) from which an in vivo dose-response curve and a PoD for risk assessment were derived. The predicted PoD lies within the variation of the NOAELs obtained from in vivo developmental toxicity data from the literature. In conclusion, the present study showed that it was possible to accurately predict a PoD for the risk assessment of phenol using in vitro toxicity data combined with reverse PBK modelling.

  6. Cumulative response curves to enhance interpretation of treatment differences on the Self-Esteem And Relationship questionnaire for men with erectile dysfunction.

    Science.gov (United States)

    Cappelleri, Joseph C; Zou, Kelly H; Bushmakin, Andrew G; Carlsson, Martin O; Symonds, Tara

    2013-03-01

    What's known on the subject? and What does the study add? Studies on erectile dysfunction (ED) therapies rely heavily on patient-reported outcomes (PROs) to measure efficacy on treatment response. A challenge when using PROs is interpretation of the clinical meaning of changes in scores. A responder analysis provides a threshold score to indicate whether a change in score qualifies a patient as a responder. However, a major consideration with responder analysis is the sometimes arbitrary nature of defining the threshold for a response. By contrast, cumulative response curves (CRCs) display patient response rates over a continuum of possible thresholds, thus eliminating problems with a rigid threshold definition, allowing for a variety of response thresholds to be examined simultaneously, and encompassing all data. With respect to the psychosocial factors addressed in the Self-Esteem And Relationship questionnaire in ED, CRCs clearly, distinctly, and meaningfully highlighted the favourable profiles of responses to sildenafil compared with placebo. CRCs for PROs in urology can provide a clear, transparent and meaningful visual depiction of efficacy data that can supplement and complement other analyses. To use cumulative response curves (CRCs) to enrich meaning and enhance interpretation of scores on the Self-Esteem And Relationship (SEAR) questionnaire with respect to treatment differences for men with erectile dysfunction (ED). This post hoc analysis used data from all patients who took at least one dose of study drug and had at least one post-baseline efficacy evaluation in a previously published 12-week, multicentre, randomized, double-blind, placebo-controlled trial of flexible-dose (25, 50, or 100 mg) sildenafil citrate (Viagra) in adult men with ED who had scored ≤ 75 out of 100 on the Self-Esteem subscale of the SEAR questionnaire. CRCs were used on the numeric change in transformed SEAR scores from baseline to end-of-study for each SEAR component. The

  7. Analysis Test of Understanding of Vectors with the Three-Parameter Logistic Model of Item Response Theory and Item Response Curves Technique

    Science.gov (United States)

    Rakkapao, Suttida; Prasitpong, Singha; Arayathanitkul, Kwan

    2016-01-01

    This study investigated the multiple-choice test of understanding of vectors (TUV), by applying item response theory (IRT). The difficulty, discriminatory, and guessing parameters of the TUV items were fit with the three-parameter logistic model of IRT, using the parscale program. The TUV ability is an ability parameter, here estimated assuming…

  8. Task-based detectability comparison of exponential transformation of free-response operating characteristic (EFROC) curve and channelized Hotelling observer (CHO)

    Science.gov (United States)

    Khobragade, P.; Fan, Jiahua; Rupcich, Franco; Crotty, Dominic J.; Gilat Schmidt, Taly

    2016-03-01

    This study quantitatively evaluated the performance of the exponential transformation of the free-response operating characteristic curve (EFROC) metric, with the Channelized Hotelling Observer (CHO) as a reference. The CHO has been used for image quality assessment of reconstruction algorithms and imaging systems and often it is applied to study the signal-location-known cases. The CHO also requires a large set of images to estimate the covariance matrix. In terms of clinical applications, this assumption and requirement may be unrealistic. The newly developed location-unknown EFROC detectability metric is estimated from the confidence scores reported by a model observer. Unlike the CHO, EFROC does not require a channelization step and is a non-parametric detectability metric. There are few quantitative studies available on application of the EFROC metric, most of which are based on simulation data. This study investigated the EFROC metric using experimental CT data. A phantom with four low contrast objects: 3mm (14 HU), 5mm (7HU), 7mm (5 HU) and 10 mm (3 HU) was scanned at dose levels ranging from 25 mAs to 270 mAs and reconstructed using filtered backprojection. The area under the curve values for CHO (AUC) and EFROC (AFE) were plotted with respect to different dose levels. The number of images required to estimate the non-parametric AFE metric was calculated for varying tasks and found to be less than the number of images required for parametric CHO estimation. The AFE metric was found to be more sensitive to changes in dose than the CHO metric. This increased sensitivity and the assumption of unknown signal location may be useful for investigating and optimizing CT imaging methods. Future work is required to validate the AFE metric against human observers.

  9. J-curve relation between daytime nap duration and type 2 diabetes or metabolic syndrome: A dose-response meta-analysis.

    Science.gov (United States)

    Yamada, Tomohide; Shojima, Nobuhiro; Yamauchi, Toshimasa; Kadowaki, Takashi

    2016-12-02

    Adequate sleep is important for good health, but it is not always easy to achieve because of social factors. Daytime napping is widely prevalent around the world. We performed a meta-analysis to investigate the association between napping (or excessive daytime sleepiness: EDS) and the risk of type 2 diabetes or metabolic syndrome, and to quantify the potential dose-response relation using cubic spline models. Electronic databases were searched for articles published up to 2016, with 288,883 Asian and Western subjects. Pooled analysis revealed that a long nap (≥60 min/day) and EDS were each significantly associated with an increased risk of type 2 diabetes versus no nap or no EDS (odds ratio 1.46 (95% CI 1.23-1.74, p Dose-response meta-analysis showed a J-curve relation between nap time and the risk of diabetes or metabolic syndrome, with no effect of napping up to about 40 minutes/day, followed by a sharp increase in risk at longer nap times. In summary, longer napping is associated with an increased risk of metabolic disease. Further studies are needed to confirm the benefit of a short nap.

  10. Metallicities of Emission-Line Galaxies from HST ACS PEARS and HST WFC3 ERS Grism Spectroscopy at 0.6 < z < 2.4

    CERN Document Server

    Xia, Lifang; Rhoads, James; Pirzkal, Nor; Straughn, Amber; Finkelstein, Steven; Cohen, Seth; Kuntschner, Harald; Kümmel, Martin; Walsh, Jeremy; Windhorst, Rogier A; O'Connell, Robert

    2012-01-01

    Galaxies selected on the basis of their emission line strength show low metallicities, regardless of their redshifts. We conclude this from a sample of faint galaxies at redshifts between 0.6 < z < 2.4, selected by their prominent emission lines in low-resolution grism spectra in the optical with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope (HST) and in the near-infrared using Wide-Field Camera 3 (WFC3). Using a sample of 11 emission line galaxies (ELGs) at 0.6 < z < 2.4 with luminosities of -22 < M_B < -19, which have [OII], H\\beta, and [OIII] line flux measurements from the combination of two grism spectral surveys, we use the R23 method to derive the gas-phase oxygen abundances: 7.5 < 12+log(O/H) < 8.5. The galaxy stellar masses are derived using Bayesian based Markov Chain Monte Carlo (\\piMC^2) fitting of their Spectral Energy Distribution (SED), and span the mass range 8.1 < log(M_*/M_\\sun) < 10.1. These galaxies show a mass-metallicity (M-L) and Lumin...

  11. The Grism Lens-Amplified Survey from Space (GLASS). III. A census of Ly\\alpha\\ Emission at $z\\gtrsim$7 from HST Spectroscopy

    CERN Document Server

    Schmidt, K B; Bradač, M; Vulcani, B; Huang, K -H; Hoag, A; Maseda, M; Guaita, L; Pentericci, L; Brammer, G B; Dijkstra, M; Dressler, A; Fontana, A; Henry, A L; Jones, T A; Mason, C; Trenti, M; Wang, X

    2015-01-01

    [abbreviated] We present a census of Ly\\alpha\\ emission at $z\\gtrsim7$ utilizing deep near infrared HST grism spectroscopy from the first six completed clusters of the Grism Lens-Amplified Survey from Space (GLASS). In 24/159 photometrically selected galaxies we detect emission lines consistent with Ly\\alpha\\ in the GLASS spectra. Based on the distribution of signal-to-noise ratios and on simulations we expect the completeness and the purity of the sample to be 40-100% and 60-90%, respectively. For the objects without detected emission lines we show that the observed (not corrected for lensing magnification) 1$\\sigma$ flux limits reaches $5\\times10^{-18}$erg/s/cm$^{2}$ per position angle over the full wavelength range of GLASS (0.8-1.7$\\mu$m). Based on the conditional probability of Ly\\alpha\\ emission measured from the ground at $z\\sim7$ we would have expected 12-18 Ly\\alpha\\ emitters. This is consistent with the number of detections, within the uncertainties, confirming the drop in Ly\\alpha\\ emission with re...

  12. First results from Faint Infrared Grism Survey (FIGS): first simultaneous detection of Lyman-{\\alpha} emission and Lyman break from a galaxy at z=7.51

    CERN Document Server

    Tilvi, V; Malhotra, S; Finkelstein, S L; Rhoads, J E; Windhorst, R; Grogin, N A; Koekemoer, A; Zakamska, N; Ryan, R; Christensen, L; Hathi, N; Pharo, J; Joshi, B; Yang, H; Gronwall, C; Cimatti, A; Walsh, J; OConnell, R; Straughn, A; Ostlin, G; Rothberg, B; Livermore, R C; Hibon, P; Gardner, Jonathan P

    2016-01-01

    Galaxies at high redshifts provide a valuable tool to study cosmic dawn, and therefore it is crucial to reliably identify these galaxies. Here, we present an unambiguous and first simultaneous detection of both the Lyman-\\alpha emission and the Lyman break from a z = 7.512+/- 0.004 galaxy, observed in the Faint Infrared Grism Survey (FIGS). These spectra, taken with G102 grism on Hubble Space Telescope (HST), show a significant emission line detection (6{\\sigma}) in multiple observational position angles (PA), with total integrated Ly{\\alpha} line flux of 1.06+/- 0.12 e10-17erg s-1cm-2. The line flux is nearly a factor of four higher than the previous MOSFIRE spectroscopic observations of faint Ly{\\alpha} emission at {\\lambda} = 1.0347{\\mu}m, yielding z = 7.5078+/- 0.0004. This is consistent with other recent observations implying that ground-based near-infrared spectroscopy underestimates total emission line fluxes, and if confirmed, can have strong implications for reionization studies that are based on gro...

  13. Assessing the spatial variability in peak season CO2 exchange characteristics across the Arctic tundra using a light response curve parameterization

    Directory of Open Access Journals (Sweden)

    H. N. Mbufong

    2014-05-01

    Full Text Available This paper aims to assess the functional and spatial variability in the response of CO2 exchange to irradiance across the Arctic tundra during peak season using light response curve (LRC parameters. This investigation allows us to better understand the future response of Arctic tundra under climatic change. Data was collected using the micrometeorological eddy covariance technique from 12 circumpolar Arctic tundra sites, in the range of 64–74° N. The LRCs were generated for 14 days with peak net ecosystem exchange (NEE using an NEE -irradiance model. Parameters from LRCs represent site specific traits and characteristics describing: (a NEE at light saturation (Fcsat, (b dark respiration (Rd, (c light use efficiency (α, (d NEE when light is at 1000 μmol m−2 s−1 (Fc1000, (e potential photosynthesis at light saturation (Psat and (f the light compensation point (LCP. Parameterization of LRCs was successful in predicting CO2 flux dynamics across the Arctic tundra. Yet we did not find any trends in LRC parameters across the whole Arctic tundra but there were indications for temperature and latitudinal differences within sub-regions like Russia and Greenland. Together, LAI and July temperature had a high explanatory power of the variance in assimilation parameters (Fcsat, Fc1000 and Psat, thus illustrating the potential for upscaling CO2 exchange for the whole Arctic tundra. Dark respiration was more variable and less correlated to environmental drivers than was assimilation parameters. Thus, indicating the inherent need to include other parameters such as nutrient availability, substrate quantity and quality in flux monitoring activities.

  14. Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Thomas A. D.; Hogstrom, Kenneth R.; Alvarez, Diane; Matthews, Kenneth L. II; Ham, Kyungmin; Dugas, Joseph P. [Mary Bird Perkins Cancer Center, 4950 Essen Lane, Baton Rouge, Louisiana 70809 and Department of Physics and Astronomy, Louisiana State University and A and M College, 202 Nicholson Hall, Baton Rouge, Louisiana 70803 (United States); Department of Physics and Astronomy, Louisiana State University and A and M College, 202 Nicholson Hall, Baton Rouge, Louisiana 70803 (United States); Center for Advanced Microstructures and Devices, Louisiana State University and A and M College, 6980 Jefferson Highway, Baton Rouge, Louisiana 70806 (United States); Mary Bird Perkins Cancer Center, 4950 Essen Lane, Baton Rouge, Louisiana 70809 and Department of Physics and Astronomy, Louisiana State University and A and M College, 202 Nicholson Hall, Baton Rouge, Louisiana 70803 (United States)

    2012-12-15

    Purpose: This work investigates the dose-response curves of GAFCHROMIC{sup Registered-Sign} EBT, EBT2, and EBT3 radiochromic films using synchrotron-produced monochromatic x-ray beams. EBT2 film is being utilized for dose verification in photoactivated Auger electron therapy at the Louisiana State University Center for Advanced Microstructures and Devices (CAMD) synchrotron facility. Methods: Monochromatic beams of 25, 30, and 35 keV were generated on the tomography beamline at CAMD. Ion chamber depth-dose measurements were used to determine the dose delivered to films irradiated at depths from 0.7 to 8.5 cm in a 10 Multiplication-Sign 10 Multiplication-Sign 10-cm{sup 3} polymethylmethacrylate phantom. AAPM TG-61 protocol was applied to convert measured ionization into dose. Films were digitized using an Epson 1680 Professional flatbed scanner and analyzed using the net optical density (NOD) derived from the red channel. A dose-response curve was obtained at 35 keV for EBT film, and at 25, 30, and 35 keV for EBT2 and EBT3 films. Calibrations of films for 4 MV x-rays were obtained for comparison using a radiotherapy accelerator at Mary Bird Perkins Cancer Center. Results: The sensitivity (NOD per unit dose) of EBT film at 35 keV relative to that for 4-MV x-rays was 0.73 and 0.76 for doses 50 and 100 cGy, respectively. The sensitivity of EBT2 film at 25, 30, and 35 keV relative to that for 4-MV x-rays varied from 1.09-1.07, 1.23-1.17, and 1.27-1.19 for doses 50-200 cGy, respectively. For EBT3 film the relative sensitivity was within 3% of unity for all three monochromatic x-ray beams. Conclusions: EBT and EBT2 film sensitivity showed strong energy dependence over an energy range of 25 keV-4 MV, although this dependence becomes weaker for larger doses. EBT3 film shows weak energy dependence, indicating that it would be a better dosimeter for kV x-ray beams where beam hardening effects can result in large changes in the effective energy.

  15. Validation of dose-response curve of CRCN-NE - Regional Center for Nuclear Sciences from Northeast Brazil for {sup 60}Co: preliminary results; Validacao da curva dose-resposta do CRCN-NE para {sup 60}Co: resultados preliminares

    Energy Technology Data Exchange (ETDEWEB)

    Mendonca, Julyanne C.G.; Mendes, Mariana E.; Hwang, Suy F.; Lima, Fabiana F. [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil); Santos, Neide, E-mail: july_cgm@yahoo.com.br [Universidade Federal de Pernambuco (CCB/UFPE), Recife, PE (Brazil). Departamento de Genetica

    2014-07-01

    The cytogenetic study has the chromosomal alterations as biomarkers in absorbed dose estimation by the body of individuals involved in exposure to ionizing radiation by interpreting a dose response calibration curve. Since the development of the technique to the analysis of data, you can see protocol characteristics, leading the International Atomic Energy Agency indicate that any laboratory with intention to carry out biological dosimetry establish their own calibration curves. The Biological Dosimetry Laboratory of the Centro Regional de Ciencias Nucleares (CRCN-NE/CNEN), Brazil, recently established the calibration curve related to gamma radiation ({sup 60}Co). Thus, this work aimed to start the validation of this calibration curve from samples of three different blood donors which were irradiated with an absorbed known single dose of 1 Gy. Samples were exposed to {sup 60}Co source (Glaucoma 220) located in the Department of Nuclear Energy (DEN/UFPE). After fixation with methanol and acetic acid and 5% Giemsa staining, the frequency of chromosomal alterations (dicentric chromosomes, acentric rings and fragments) were established from reading of 500 metaphases per sample and doses were estimated using Dose Estimate program. The results showed that, using the dose-response curve calibration for dicentrics, the dose absorbed estimated for the three individuals ranged from 0.891 - 1,089Gy, taking into account the range of confidence of 95%. By using the dose-response curve for dicentrics added to rings and for the same interval of confidence the doses ranged from 0,849 - 1,081Gy. Thus, the estimative encompassed known absorbed dose the three individuals in confidence interval of 95%. These preliminary results seems to demonstrate that dicentric dose-response curves and dicentrics plus rings established by CRCN-NE / CNEN are valid for dose estimation in exposed individuals. This validation will continue with samples from different individuals at different doses.

  16. Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.

    Science.gov (United States)

    Luszczki, Jarogniew J

    2008-11-01

    The aim of this study was to characterize the interaction between tiagabine (TGB) and ethosuximide (ETS), two antiepileptic drugs, in pentylenetetrazole (PTZ)-induced clonic seizures in mice using isobolographic analysis. The nature of the interaction between the drugs administered in combination was ascertained by estimating plasma and brain concentrations of ETS and TGB using fluorescence polarization immunoassay (FPIA) and high-performance liquid chromatography (HPLC). The results indicated that both drugs produced clear anticonvulsant effects against PTZ-induced clonic seizures in mice, but that their dose-response relationship curves (DRRCs) were not parallel, consequently necessitating the isobolographic analysis for non-parallel DRRCs. The isobolographic analysis revealed that the combination of TGB with ETS at the fixed-ratio of 1:1 exerted an additive interaction against PTZ-induced clonic seizures in mice. FPIA documented that TGB significantly elevated brain ETS concentrations (by 64%), while having no effect on plasma ETS concentrations in experimental animals. In contrast, ETS had no significant impact on plasma and brain concentrations of TGB in mice, as measured by HPLC. It can be concluded that the additive interaction between TGB and ETS at the fixed-ratio of 1:1 in the PTZ test was complicated by a significant pharmacokinetic increase in total brain ETS concentrations. At present, there are no recommendations to use this drug combination in epileptic patients.

  17. ESR dosimetry of fossil enamel: some comments about measurement precision, long-term signal fading and dose-response curve fitting.

    Science.gov (United States)

    Duval, M; Guilarte Moreno, V; Grün, R

    2013-12-01

    This work deals with the specific studies of three main sources of uncertainty in electron spin resonance (ESR) dosimetry/dating of fossil tooth enamel: (1) the precision of the ESR measurements, (2) the long-term signal fading the selection of the fitting function. They show a different influence on the equivalent dose (D(E)) estimates. Repeated ESR measurements were performed on 17 different samples: results show a mean coefficient of variation of the ESR intensities of 1.20 ± 0.23 %, inducing a mean relative variability of 3.05 ± 2.29 % in the D(E) values. ESR signal fading over 5 y was also observed: its magnitude seems to be quite sample dependant but is nevertheless especially important for the most irradiated aliquots. This fading has an apparent random effect on the D(E) estimates. Finally, the authors provide new insights and recommendations about the fitting of ESR dose-response curves of fossil enamel with a double saturating exponential (DSE) function. The potential of a new variation of the DSE was also explored. Results of this study also show that the choice of the fitting function is of major importance, maybe more than the other sources previously mentioned, in order to get accurate final D(E) values.

  18. For whom the bell (curve) tolls: cortisol rapidly affects memory retrieval by an inverted U-shaped dose-response relationship.

    Science.gov (United States)

    Schilling, Thomas M; Kölsch, Monika; Larra, Mauro F; Zech, Carina M; Blumenthal, Terry D; Frings, Christian; Schächinger, Hartmut

    2013-09-01

    Stress and cortisol are generally considered to impair declarative memory retrieval, although opposite results have also been reported. Dose-dependent effects and differences between genomic and non-genomic cortisol effects are possible reasons for these discrepancies. The aim of the current experiment was to assess the non-genomic effects of escalating doses of intravenous cortisol on cued recall of socially relevant information in humans. 40 participants (age range 20-30 years; 20 females) learned associations between male faces with a neutral facial expression and descriptions of either positive or negative social behaviors and were tested one week later in a cued recall paradigm. Escalating doses of cortisol (0, 3, 6, 12, 24 mg) were administered 8 min before testing according to a between-subjects design. An inverted U-shaped dose-response relationship between salivary cortisol levels and recall performance was observed, with moderate elevation of salivary cortisol resulting in the best recall performance. This is the first study in humans demonstrating that cortisol rapidly modulates declarative memory retrieval via a dose-dependent, non-genomic mechanism that follows an inverted U-shaped curve. Our result further emphasizes the importance of fast cortisol effects for human cognition.

  19. The Roles of Macrobenthic Mollusks as Bioindicator in Response to Environmental Disturbance : Cumulative k-dominance curves and bubble plots ordination approaches

    Science.gov (United States)

    Putro, Sapto P.; Muhammad, Fuad; Aininnur, Amalia; Widowati; Suhartana

    2017-02-01

    Floating net cage is one of the aquaculture practice operated in Indonesian coastal areas that has been growing rapidly over the last two decades. This study is aimed to assess the roles of macrobenthic mollusks as bioindicator in response to environmental disturbance caused by fish farming activities, and compare the samples within the locations using graphical methods. The research was done at the floating net cage fish farming area in the Awerange Gulf, South Sulawesi, Indonesia at the coordinates between 79°0500‧- 79°1500‧ LS and 953°1500‧- 953°2000‧ BT, at the polyculture and reference areas, which was located 1 km away from farming area. Sampling period was conducted between October 2014 to June 2015. The sediment samples were taken from the two locations with two sampling time and three replicates using Van Veen Grab for biotic and abiotic assessment. Mollusks as biotic parameter were fixed using 4% formalin solution and were preserved using 70% ethanol solution after 1mm mesh size. The macrobenthic mollusks were found as many as 15 species consisting of 14 families and 2 classes (gastropods and bivalves). Based on cumulative k-dominance analysis projected on each station, the line of station K3T1 (reference area; first sampling time) and KJAB P3T2 (polyculture area; second sampling time) are located below others curves, indicating the highest evenness and diversity compared to the other stations, whereas station K2T1 (reference area; first sampling time) and K3T2 (polyculture area, second sampling time) are located on the top, indicate the lowest value of evenness and diversity. Based on the bubble plots NMDS ordination, the four dominant taxa/species did not clearly show involvement in driving/shifting the ordinate position of station on the graph, except T. agilis. However, the two species showed involvement in driving/shifting the ordinate position of two stations of the reference areas from the first sampling time by Rynoclavis sordidula

  20. Multiphasic growth curve analysis.

    NARCIS (Netherlands)

    Koops, W.J.

    1986-01-01

    Application of a multiphasic growth curve is demonstrated with 4 data sets, adopted from literature. The growth curve used is a summation of n logistic growth functions. Human height growth curves of this type are known as "double logistic" (n = 2) and "triple logistic" (n = 3) growth curves (Bock

  1. Study of Ground Response Curve (GRC) Based on a Damage Model / Badanie Krzywej Odpowiedzi Gruntu (Grc) W Oparciu O Model Pękania Skał

    Science.gov (United States)

    Molladavoodi, H.

    2013-09-01

    Analysis of stresses and displacements around underground openings is necessary in a wide variety of civil, petroleum and mining engineering problems. In addition, an excavation damaged zone (EDZ) is generally formed around underground openings as a result of high stress magnitudes even in the absence of blasting effects. The rock materials surrounding the underground excavations typically demonstrate nonlinear and irreversible mechanical response in particular under high in situ stress states. The dominant cause of irreversible deformations in brittle rocks is damage process. One of the most widely used methods in tunnel design is the convergence-confinement method (CCM) for its practical application. The elastic-plastic models are usually used in the convergence-confinement method as a constitutive model for rock behavior. The plastic models used to simulate the rock behavior, do not consider the important issues such as stiffness degradation and softening. Therefore, the use of damage constitutive models in the convergence-confinement method is essential in the design process of rock structures. In this paper, the basic concepts of continuum damage mechanics are outlined. Then a numerical stepwise procedure for a circular tunnel under hydrostatic stress field, with consideration of a damage model for rock mass has been implemented. The ground response curve and radius of excavation damage zone were calculated based on an isotropic damage model. The convergence-confinement method based on damage model can consider the effects of post-peak rock behavior on the ground response curve and excavation damage zone. The analysis of results show the important effect of brittleness parameter on the tunnel wall convergence, ground response curve and excavation damage radius. Analiza naprężeń i przemieszczeń powstałych wokół otworu podziemnego wymagana jest przy szerokiej gamie projektów z zakresu budownictwa lądowego, inżynierii górniczej oraz naftowej. Ponadto

  2. The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.

    NARCIS (Netherlands)

    Louisse, J.; de Jong, E.; van de Sandt, J.J.M.; Blaauboer, B.J.; Woutersen, R.A.; Piersma, A.H.; Rietjens, I.M.C.M.; Verwei, M.

    2010-01-01

    At present, regulatory assessment of systemic toxicity is almost solely performed using animal models. The EU REACH legislation stimulates the use of animal-free approaches to obtain information on the toxicity of chemicals. In vitro toxicity tests provide in vitro concentration-response curves for

  3. Emission-Line Galaxies from the Hubble Space Telescope Probing Evolution and Reionization Spectroscopically (PEARS) Grism Survey. II: The Complete Sample

    CERN Document Server

    Pirzkal, Nor; Ly, Chun; Malhotra, Sangeeta; Rhoads, James E; Grogin, Norman A; Dahlen, Tomas; Meurer, Gerhardt R; Walsh, Jeremy R; Hathi, Nimish P; Cohen, Seth H; Bellini, Andrea; Holwerda, Benne W; Straughn, Amber N; Mechtley, Matthew

    2012-01-01

    We present a full analysis of the Probing Evolution And Reionization Spectroscopically (PEARS) slitess grism spectroscopic data obtained with the Advanced Camera for Surveys on HST. PEARS covers fields within both the Great Observatories Origins Deep Survey (GOODS) North and South fields, making it ideal as a random survey of galaxies, as well as the availability of a wide variety of ancillary observations to support the spectroscopic results. Using the PEARS data we are able to identify star forming galaxies within the redshift volume 0 1e9} M_sun decreases by an order of magnitude at z<0.5 relative to the number at 0.5

  4. The Grism Lens-Amplified Survey from Space (GLASS). VI. Comparing the Mass and Light in MACSJ0416.1-2403 using Frontier Field imaging and GLASS spectroscopy

    CERN Document Server

    Hoag, Austin; Treu, Tommaso; Bradač, Maruša; Schmidt, Kasper B; Wang, Xin; Brammer, Gabriel B; Broussard, Adam; Amorin, Ricardo; Castellano, Marco; Fontana, Adriano; Merlin, Emiliano; Schrabback, Tim; Trenti, Michele; Vulcani, Benedetta

    2016-01-01

    We present a strong and weak gravitational lens model of the galaxy cluster MACSJ0416.1-2403, constrained using spectroscopy from the Grism Lens-Amplified Survey from Space (GLASS) and Hubble Frontier Fields (HFF) imaging data. We search for emission lines in known multiply imaged sources in the GLASS spectra, obtaining secure spectroscopic redshifts of 31 multiple images belonging to 16 distinct source galaxies. The GLASS spectra provide the first spectroscopic measurements for 6 of the source galaxies. The weak lensing signal is acquired from 884 galaxies in the F606W HFF image. By combining the weak lensing constraints with 15 multiple image systems with spectroscopic redshifts and 9 multiple image systems with photometric redshifts, we reconstruct the gravitational potential of the cluster on an adaptive grid. The resulting total mass density map is compared with a stellar mass density map obtained from the deep Spitzer Frontier Fields imaging data to study the relative distribution of stellar and total m...

  5. Effect of iron salt counter ion in dose-response curves for inactivation of Fusarium solani in water through solar driven Fenton-like processes

    Science.gov (United States)

    Aurioles-López, Verónica; Polo-López, M. Inmaculada; Fernández-Ibáñez, Pilar; López-Malo, Aurelio; Bandala, Erick R.

    2016-02-01

    The inactivation of Fusarium solani in water was assessed by solar driven Fenton-like processes using three different iron salts: ferric acetylacetonate (Fe(acac)3), ferric chloride (FeCl3) and ferrous sulfate (FeSO4). The experimental conditions tested were [Fe] ≈ 5 mg L-1, [H2O2] ≈ 10 mg L-1 and [Fe] ≈ 10 mg L-1; [H2O2] ≈ 20 mg L-1 mild and high, respectively, and pH 3.0 and 5.0, under solar radiation. The highest inactivation rates were observed at high reaction conditions for the three iron salts tested at pH 5.0 with less than 3.0 kJ L-1 of accumulate energy (QUV) to achieve over 99.9% of F. solani inactivation. Fe(acac)3 was the best iron salt to accomplishing F. solani inactivation. The modified Fermi equation was used to fix the experimental inactivation, data showed it was helpful for modeling the process, adequately describing dose-response curves. Inactivation process using FeSO4 at pH 3.0 was modeled fairly with r2 = 0.98 and 0.99 (mild and high concentration, respectively). Fe(acac)3, FeCl3 and FeSO4 at high concentration (i.e. [Fe] ≈ 10 mg L-1; [H2O2] ≈ 20 mg L-1) and pH 5.0 showed the highest fitting values (r2 = 0.99). Iron salt type showed a remarkable influence on the Fenton-like inactivation process.

  6. Photosynthetic traits of five neotropical rainforest tree species: interactions between light response curves and leaf-to-air vapour pressure deficit

    Directory of Open Access Journals (Sweden)

    Marcelo Schramm Mielke

    2005-09-01

    Full Text Available Measurements of leaf gas exchange at different photosynthetic photon flux density (PPFD levels were conducted in order to compare the photosynthetic traits of five neotropical rainforest tree species, with a special emphasis on empirical mathematical models to estimate the light response curve parameters incorporating the effects of leaf-to-air vapour pressure deficit (D on the saturated photosynthetic rate (Amax. All empirical mathematical models seemed to provide a good estimation of the light response parameters. Comparisons of the leaf photosynthetic traits between different species needed to select an appropriate model and indicated the microenvironmental conditions when the data were collected. When the vapour pressure deficit inside the chamber was not controlled, the incorporation of linear or exponencial functions that explained the effects of D on leaf gas exchange, was a very good method to enhance the performance of the models.Medições das trocas gasosas foliares em diferentes níveis do densidade de fluxo de fótons fotossintéticamente ativos (PPFD foram realizadas com o objetivo de comparar as características fotossintéticas de cinco espécies arbóreas de florestas úmidas neotropicais, com especial ênfase em modelos matemáticos empíricos para estimativa de parâmetros derivados das curvas de resposta à radiação luminosa e dos efeitos da diferença de pressão de vapor entre a folha e o ar (D na taxa fotossintética em saturação luminosa (Amax. Os modelos analisados proporcionaram boas estimativas para os parâmetros derivados das curvas de resposta à radiação luminosa. Comparações entre as características fotossintéticas de diferentes espécies devem sempre considerar os modelos utilizados, seguidas de indicações pormenorizadas das condições microambientais no momento em que os dados foram coletados. Quando a diferença de pressão de vapor não for controlada artificialmente durante as medições, a

  7. $Extrasolar~Storms$: Pressure-dependent Changes In Light Curve Phase In Brown Dwarfs From Simultaneous $Hubble$ and $Spitzer$ Observations

    CERN Document Server

    Yang, Hao; Marley, Mark S; Karalidi, Theodora; Flateau, Davin; Showman, Adam P; Metchev, Stanimir; Buenzli, Esther; Radigan, Jacqueline; Artigau, Étienne; Lowrance, Patrick J; Burgasser, Adam J

    2016-01-01

    We present $Spitzer$/IRAC Ch1 and Ch2 monitoring of six brown dwarfs during 8 different epochs over the course of 20 months. For four brown dwarfs, we also obtained simulataneous $HST$/WFC3 G141 Grism spectra during two epochs and derived light curves in five narrow-band filters. Probing different pressure levels in the atmospheres, the multi-wavelength light curves of our six targets all exhibit variations, and the shape of the light curves evolves over the timescale of a rotation period, ranging from 1.4 h to 13 h. We compare the shapes of the light curves and estimate the phase shifts between the light curves observed at different wavelengths by comparing the phase of the primary Fourier components. We use state-of-the-art atmosphere models to determine the flux contribution of different pressure layers to the observed flux in each filter. We find that the light curves that probe higher pressures are similar and in phase, but are offset and often different from the light curves that probe lower pressures. ...

  8. Spinal curves (image)

    Science.gov (United States)

    There are four natural curves in the spinal column. The cervical, thoracic, lumbar, and sacral curvature. The curves, along with the intervertebral disks, help to absorb and distribute stresses that occur from everyday activities such as walking or from ...

  9. Contractibility of curves

    Directory of Open Access Journals (Sweden)

    Janusz Charatonik

    1991-11-01

    Full Text Available Results concerning contractibility of curves (equivalently: of dendroids are collected and discussed in the paper. Interrelations tetween various conditions which are either sufficient or necessary for a curve to be contractible are studied.

  10. Parametrizing Algebraic Curves

    OpenAIRE

    Lemmermeyer, Franz

    2011-01-01

    We present the technique of parametrization of plane algebraic curves from a number theorist's point of view and present Kapferer's simple and beautiful (but little known) proof that nonsingular curves of degree > 2 cannot be parametrized by rational functions.

  11. Biological effects in lymphocytes irradiated with {sup 99m}Tc: determination of the curve dose-response; Efeitos biologicos em linfocitos irradiados com {sup 99m}Tc: determinacao da curva dose-resposta

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Romero Marcilio Barros Matias de

    2002-08-01

    Biological dosimetry estimates the absorbed dose taking into account changes in biological parameters. The most used biological indicator of an exposition to ionizing radiation is the quantification of chromosomal aberrations of lymphocytes from irradiated individuals. The curves of dose versus induced biological effects, obtained through bionalyses, are used in used in retrospective evaluations of the dose, mainly in the case of accidents. In this research, a simple model for electrons and photons transports was idealized to simulate the irradiation of lymphocytes with {sup 99m} Tc, representing a system used for irradiation of blood cells. The objective of the work was to establish a curve of dose versus frequencies of chromosomal aberrations in lymphocytes of human blood. For the irradiation of blood samples micro spheres of human serum of albumin (HSAM) market with {sup 99m} Tc were used, allowing the irradiation of blood with different administered activities of {sup 99m} Tc, making possible the study the cytogenetical effects as a function of such activities. The conditions of irradiation in vivo using HSAM spheres marked with {sup 99m} Tc were simulated with MCNP 4C (Monte Carlo N-Particle) code to obtain the dose-response curve. Soft tissue composition was employed to simulate blood tissue and the analyses of the curve of dose versus biological effect showed a linear quadratic response of the unstable chromosomal aberrations. As a result, the response of dose versus chromosomal aberrations of blood irradiation with {sup 99m} Tc was best fitted by the curve Y=(8,99 {+-}2,06) x 1-{sup -4} + (1,24 {+-}0,62) x 10{sup -2} D + (5,67 {+-} 0,64) x 10{sup -2} D{sup 2}. (author)

  12. A curve-fitting approach to estimate the arterial plasma input function for the assessment of glucose metabolic rate and response to treatment.

    NARCIS (Netherlands)

    Vriens, D.; Geus-Oei, L.F. de; Oyen, W.J.G.; Visser, E.P.

    2009-01-01

    For the quantification of dynamic (18)F-FDG PET studies, the arterial plasma time-activity concentration curve (APTAC) needs to be available. This can be obtained using serial sampling of arterial blood or an image-derived input function (IDIF). Arterial sampling is invasive and often not feasible i

  13. ECM using Edwards curves

    DEFF Research Database (Denmark)

    Bernstein, Daniel J.; Birkner, Peter; Lange, Tanja;

    2013-01-01

    This paper introduces EECM-MPFQ, a fast implementation of the elliptic-curve method of factoring integers. EECM-MPFQ uses fewer modular multiplications than the well-known GMP-ECM software, takes less time than GMP-ECM, and finds more primes than GMP-ECM. The main improvements above the modular......-arithmetic level are as follows: (1) use Edwards curves instead of Montgomery curves; (2) use extended Edwards coordinates; (3) use signed-sliding-window addition-subtraction chains; (4) batch primes to increase the window size; (5) choose curves with small parameters and base points; (6) choose curves with large...

  14. METALLICITIES OF EMISSION-LINE GALAXIES FROM HST ACS PEARS AND HST WFC3 ERS GRISM SPECTROSCOPY AT 0.6 < z < 2.4

    Energy Technology Data Exchange (ETDEWEB)

    Xia Lifang; Malhotra, Sangeeta; Rhoads, James; Cohen, Seth; Windhorst, Rogier A. [School of Earth and Space Exploration, Arizona State University, AZ 85287-1404 (United States); Pirzkal, Nor [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Straughn, Amber [Astrophysics Science Division, Goddard Space Flight Center, Code 665, Greenbelt, MD 20771 (United States); Finkelstein, Steven [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States); Kuntschner, Harald; Kuemmel, Martin; Walsh, Jeremy [European Southern Observatory, Karl Schwarzschild Str. 2, D-85748 Garching (Germany); O' Connell, Robert, E-mail: lifang.xia@asu.edu [Department of Astronomy, University of Virginia, Charlottesville, VA 22904-4325 (United States)

    2012-07-15

    Galaxies selected on the basis of their emission-line strength show low metallicities, regardless of their redshifts. We conclude this from a sample of faint galaxies at redshifts between 0.6 < z < 2.4, selected by their prominent emission lines in low-resolution grism spectra in the optical with the Advanced Camera for Surveys on the Hubble Space Telescope and in the near-infrared using Wide-Field Camera 3. Using a sample of 11 emission-line galaxies at 0.6 < z < 2.4 with luminosities of -22 {approx}< M{sub B} {approx}< -19 which have [O II], H{beta}, and [O III] line flux measurements from the combination of two grism spectral surveys, we use the R23 method to derive the gas-phase oxygen abundances: 7.5 < 12 + log (O/H) < 8.5. The galaxy stellar masses are derived using Bayesian-based Markov Chain Monte Carlo ({pi}MC{sup 2}) fitting of their spectral energy distribution, and span the mass range 8.1 < log (M{sub *}/M{sub Sun} ) < 10.1. These galaxies show mass-metallicity (M-Z) and luminosity-metallicity (L-Z) relations, which are offset by -0.6 dex in metallicity at given absolute magnitude and stellar mass relative to the local Sloan Digital Sky Survey galaxies, as well as continuum-selected DEEP2 samples at similar redshifts. The emission-line-selected galaxies most resemble the local 'green peas' galaxies and Ly{alpha} galaxies at z {approx_equal} 0.3 and z {approx_equal} 2.3 in the M-Z and L-Z relations and their morphologies. The G - M{sub 20} morphology analysis shows that 10 out of 11 show disturbed morphology, even as the star-forming regions are compact. These galaxies may be intrinsically metal poor, being at early stages of formation, or the low metallicities may be due to gas infall and accretion due to mergers.

  15. Pencils on real curves

    CERN Document Server

    Coppens, Marc

    2011-01-01

    We consider coverings of real algebraic curves to real rational algebraic curves. We show the existence of such coverings having prescribed topological degree on the real locus. From those existence results we prove some results on Brill-Noether Theory for pencils on real curves. For coverings having topological degree 0 we introduce the covering number k and we prove the existence of coverings of degree 4 with prescribed covering number.

  16. JUMPING THE CURVE

    Directory of Open Access Journals (Sweden)

    René Pellissier

    2012-01-01

    Full Text Available This paper explores the notion ofjump ing the curve,following from Handy 's S-curve onto a new curve with new rules policies and procedures. . It claims that the curve does not generally lie in wait but has to be invented by leadership. The focus of this paper is the identification (mathematically and inferentially ofthat point in time, known as the cusp in catastrophe theory, when it is time to change - pro-actively, pre-actively or reactively. These three scenarios are addressed separately and discussed in terms ofthe relevance ofeach.

  17. Variability among polysulphone calibration curves

    Energy Technology Data Exchange (ETDEWEB)

    Casale, G R [University of Rome ' La Sapienza' , Physics Department, P.le A. Moro 2, I-00185, Rome (Italy); Borra, M [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Colosimo, A [University of Rome ' La Sapienza' , Department of Human Physiology and Pharmacology, P.le A. Moro 2, I-00185, Rome (Italy); Colucci, M [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Militello, A [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy); Siani, A M [University of Rome ' La Sapienza' , Physics Department, P.le A. Moro 2, I-00185, Rome (Italy); Sisto, R [ISPESL - Istituto Superiore per la Prevenzione E la Sicurezza del Lavoro, Occupational Hygiene Department, Via Fontana Candida 1, I-0040 Monteporzio Catone (RM) (Italy)

    2006-09-07

    Within an epidemiological study regarding the correlation between skin pathologies and personal ultraviolet (UV) exposure due to solar radiation, 14 field campaigns using polysulphone (PS) dosemeters were carried out at three different Italian sites (urban, semi-rural and rural) in every season of the year. A polysulphone calibration curve for each field experiment was obtained by measuring the ambient UV dose under almost clear sky conditions and the corresponding change in the PS film absorbance, prior and post exposure. Ambient UV doses were measured by well-calibrated broad-band radiometers and by electronic dosemeters. The dose-response relation was represented by the typical best fit to a third-degree polynomial and it was parameterized by a coefficient multiplying a cubic polynomial function. It was observed that the fit curves differed from each other in the coefficient only. It was assessed that the multiplying coefficient was affected by the solar UV spectrum at the Earth's surface whilst the polynomial factor depended on the photoinduced reaction of the polysulphone film. The mismatch between the polysulphone spectral curve and the CIE erythemal action spectrum was responsible for the variability among polysulphone calibration curves. The variability of the coefficient was related to the total ozone amount and the solar zenith angle. A mathematical explanation of such a parameterization was also discussed.

  18. Spectroscopic Confirmation of the Rich z=1.80 Galaxy Cluster JKCS 041 Using the WFC3 Grism: Environmental Trends in the Ages and Structure of Quiescent Galaxies

    CERN Document Server

    Newman, Andrew B; Andreon, Stefano; Treu, Tommaso; Raichoor, Anand; Trinchieri, Ginevra

    2013-01-01

    We present HST/WFC3 imaging and grism spectroscopy of the distant galaxy cluster JKCS041. Our survey yields 98 redshifts whose precision is typically ~20x better than photometric estimates. We confirm that JKCS041 is a rich cluster and derive a redshift z=1.80 via the identification of 19 member galaxies, of which 15 are quiescent. These members are spatially aligned with diffuse X-ray emission seen by Chandra. As JKCS041 is the most distant known cluster with such a large and spectroscopically-confirmed quiescent population, it provides an unique opportunity to study the effect of the environment on galaxy properties at early epochs. We construct composite spectra of the quiescent members that clearly reveal Balmer and metallic absorption lines. From these, we infer that the more massive members (log M*>11) have a mean stellar age of 1.4+0.3-0.2 Gyr, whereas lower-mass examples (log M*=10.5-11) have a younger mean age of 0.9+0.2-0.1 Gyr. These ages agree closely with those inferred by Whitaker et al. for sim...

  19. The Grism Lens-Amplified Survey from Space (GLASS). IX. The dual origin of low-mass cluster galaxies as revealed by new structural analyses

    CERN Document Server

    Morishita, Takahiro; Treu, Tommaso; Vulcani, Benedetta; Schmidt, Kasper B; Dressler, Alan; Poggianti, Bianca; Malkan, Matthew A; Wang, Xin; Huang, Kuang-Han; Trenti, Michele; Bradac, Marusa; Hoag, Austin

    2016-01-01

    Using deep Hubble Frontier Field imaging and slitless spectroscopy from the Grism Lens-Amplified Survey from Space, we analyze 2200 cluster and 1748 field galaxies at $0.2\\leq z\\leq0.7$ to determine the impact of environment on galaxy size and structure at $\\log M_*/M_\\odot>7.8$, an unprecedented limit at these redshifts. Based on both simple--$r_e= f(M_*)$--and more complex analyses--$r_e = f(M_*, C, n, z,\\Sigma)$--we find local density ($\\Sigma$) to induce a $7\\%\\pm3\\%$ ($95\\%$ confidence) reduction in half-light radii ($r_e$) beyond what can be accounted for by stellar mass ($M_*$), $U-V$ color ($C$), S\\'ersic index ($n$), and redshift ($z$) effects. Almost any size difference between galaxies in high- and low-density regions is thus attributable to their different distributions in properties other than environment. Yet, we do find a clear correlation between $U-V$ color and $r_{e}$ in low-mass red cluster galaxies ($\\log M_*/M_\\odot<9.8$) such that bluer systems are larger, with the bluest having sizes...

  20. The 3D-HST Survey: Hubble Space Telescope WFC3/G141 grism spectra, redshifts, and emission line measurements for $\\sim 100,000$ galaxies

    CERN Document Server

    Momcheva, Ivelina G; van Dokkum, Pieter G; Skelton, Rosalind E; Whitaker, Katherine E; Nelson, Erica J; Fumagalli, Mattia; Maseda, Michael V; Leja, Joel; Franx, Marijn; Rix, Hans-Walter; Bezanson, Rachel; Da Cunha, Elisabete; Dickey, Claire; Schreiber, Natascha M Förster; Illingworth, Garth; Kriek, Mariska; Labbé, Ivo; Lange, Johannes Ulf; Lundgren, Britt F; Magee, Daniel; Marchesini, Danilo; Oesch, Pascal; Pacifici, Camilla; Patel, Shannon G; Price, Sedona; Tal, Tomer; Wake, David A; van der Wel, Arjen; Wuyts, Stijn

    2015-01-01

    We present reduced data and data products from the 3D-HST survey, a 248-orbit HST Treasury program. The survey obtained WFC3 G141 grism spectroscopy in four of the five CANDELS fields: AEGIS, COSMOS, GOODS-S, and UDS, along with WFC3 $H_{140}$ imaging, parallel ACS G800L spectroscopy, and parallel $I_{814}$ imaging. In a previous paper (Skelton et al. 2014) we presented photometric catalogs in these four fields and in GOODS-N, the fifth CANDELS field. Here we describe and present the WFC3 G141 spectroscopic data, again augmented with data from GO-1600 in GOODS-N. The data analysis is complicated by the fact that no slits are used: all objects in the WFC3 field are dispersed, and many spectra overlap. We developed software to automatically and optimally extract interlaced 2D and 1D spectra for all objects in the Skelton et al. (2014) photometric catalogs. The 2D spectra and the multi-band photometry were fit simultaneously to determine redshifts and emission line strengths, taking the morphology of the galaxie...

  1. The Grism lens-amplified survey from space (GLASS). VIII. The influence of the cluster properties on Halpha emitter galaxies at 0.3

    CERN Document Server

    Vulcani, Benedetta; Nipoti, Carlo; Schmidt, Kasper B; Dressler, Alan; Morshita, Takahiro; Poggianti, Bianca M; Malkan, Matthew; Hoag, Austin; Bradač, Marusa; Abramson, Louis; Trenti, Michele; Pentericci, Laura; von der Linden, Anja; Morris, Glenn; Wang, Xin

    2016-01-01

    Exploiting the data of the Grism Lens-Amplified Survey from Space (GLASS), we characterize the spatial distribution of star formation in 76 galaxies in 10 clusters at 0.3< z <0.7. In a companion paper we contrast the properties of field and cluster galaxies, whereas here we correlate the properties of Halpha emitters to a number of tracers of the cluster environment to investigate its role in driving galaxy transformations. Halpha emitters are found in the clusters out to 0.5 virial radii, the maximum radius covered by GLASS. The peak of the Halpha emission is offset with respect to the peak of the UV-continuum. We decompose this offsets into a radial and tangential component. The radial component points away from the cluster center in 60% of the cases, with 95% confidence. The decompositions agree with cosmological simulations, i.e. the Halpha emission offset correlates with galaxy velocity and ram pressure stripping signatures. Our clusters span a wide range of morphologies. Trends between Halpha emit...

  2. Simulating Supernova Light Curves

    Energy Technology Data Exchange (ETDEWEB)

    Even, Wesley Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dolence, Joshua C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-05

    This report discusses supernova light simulations. A brief review of supernovae, basics of supernova light curves, simulation tools used at LANL, and supernova results are included. Further, it happens that many of the same methods used to generate simulated supernova light curves can also be used to model the emission from fireballs generated by explosions in the earth’s atmosphere.

  3. Tempo curves considered harmful

    NARCIS (Netherlands)

    Desain, P.; Honing, H.

    1993-01-01

    In the literature of musicology, computer music research and the psychology of music, timing or tempo measurements are mostly presented in the form of continuous curves. The notion of these tempo curves is dangerous, despite its widespread use, because it lulls its users into the false impression th

  4. Pairings on hyperelliptic curves

    CERN Document Server

    Balakrishnan, Jennifer; Chisholm, Sarah; Eisentraeger, Kirsten; Stange, Katherine; Teske, Edlyn

    2009-01-01

    We assemble and reorganize the recent work in the area of hyperelliptic pairings: We survey the research on constructing hyperelliptic curves suitable for pairing-based cryptography. We also showcase the hyperelliptic pairings proposed to date, and develop a unifying framework. We discuss the techniques used to optimize the pairing computation on hyperelliptic curves, and present many directions for further research.

  5. Retrospectives: Engel Curves

    National Research Council Canada - National Science Library

    Andreas Chai; Alessio Moneta

    2010-01-01

    ..., Professor of Economics, University of Illinois, Chicago, at jpersky@uic.edu jpersky@uic.edu.. Introduction Introduction Engel curves describe how household expenditure on particular goods or Engel curves describe how household expenditure on particular goods or services depends on household income. The name comes from the German st...

  6. Tornado-Shaped Curves

    Science.gov (United States)

    Martínez, Sol Sáez; de la Rosa, Félix Martínez; Rojas, Sergio

    2017-01-01

    In Advanced Calculus, our students wonder if it is possible to graphically represent a tornado by means of a three-dimensional curve. In this paper, we show it is possible by providing the parametric equations of such tornado-shaped curves.

  7. Study on Light Response Curve of Photosynthesis of Different Watermelons%不同西瓜材料光响应曲线特性分析

    Institute of Scientific and Technical Information of China (English)

    王红梅; 张力; 康德贤; 宋利娜; 赵晓美; 黄金艳; 李凤梅; 李文信; 覃斯华; 何毅; 李天艳; 洪日新; 樊学军

    2013-01-01

    利用Li-6400便携式光合测定仪测定了9份不同西瓜材料伸蔓期的光响应曲线,分析各材料曲线的特征参数.结果表明不同材料的光响应特征参数存在差异:最大净光合速率为W4=W5=W6=圆形花皮特早熟=长梭绿皮特早熟=桂红2号>兴桂1号>W9>W 12;表观量子效率为圆形花皮特早熟>桂红2号>W4>兴桂1号>长梭绿皮特早熟>W9>W5 >W6>W12;暗呼吸速率为桂红2号>长梭绿皮特早熟>圆形花皮特早熟>W5>W4>兴桂1号>W9>W6>W12;光补偿点为长梭绿皮特早熟>W5>桂红2号>W4>圆形花皮特早熟>W12>兴桂1号>W6>W9;光饱和点为W6>W5>长梭绿皮特早熟>W9>兴桂1号>W4>W12>桂红2号>圆形花皮特早熟.由此说明:圆形花皮特早熟、桂红2号利用弱光能力较强,长梭绿皮特早熟光合能力较强,桂红2号暗呼吸较强.圆形花皮特早熟、桂红2号在较弱光强下仍能很好地进行光合作用,与其他材料相比较耐弱光.%The light-response curves of 9 different watermelon varieties were developed at vining stage using the LI-6400 instrument for measuring photosynthesis, and then their characteristic parameters were analyzed. The maximum photosyn-thetic rates Amax were W4/W5/W6/Yuanxing-huapi-tezaoshu/Changsuo-lupi-tezaoshu/Guihong No.2>Xinggui No.1>W9> W12. The apparent quantum yields were Yuanxing-huapi-tezaoshu>Guihong No. 2>W4>Xinggui No. 1> Changsuo-lupi-tezaoshu>W9>W5>W6>W12. The dark respiration rates ranked in decreasing order of Guihong No.2,Changsuo-lupi-teza-oshu,Yuanxing-huapi-tezaoshu,W5,W4,Xinggui No.,W9,W6 and W12. The light compensation point ranked in descending order of Changsuo-lupi-tezaoshu, W5, Guihong No.2, W4, Yuanxing-huapi-tezaoshu, W12, Xinggui No. 1, W6 and W9. The light saturation point was W6>W5>Changsuo-lupi-tezaoshu>W9>Xinggui No.l>W4>W12> Guihong No.2>Yuanxing-huapi-tezaoshu. These results show that Yuanxing-huapi-tezaoshu and Guihong No.2

  8. The curve shortening problem

    CERN Document Server

    Chou, Kai-Seng

    2001-01-01

    Although research in curve shortening flow has been very active for nearly 20 years, the results of those efforts have remained scattered throughout the literature. For the first time, The Curve Shortening Problem collects and illuminates those results in a comprehensive, rigorous, and self-contained account of the fundamental results.The authors present a complete treatment of the Gage-Hamilton theorem, a clear, detailed exposition of Grayson''s convexity theorem, a systematic discussion of invariant solutions, applications to the existence of simple closed geodesics on a surface, and a new, almost convexity theorem for the generalized curve shortening problem.Many questions regarding curve shortening remain outstanding. With its careful exposition and complete guide to the literature, The Curve Shortening Problem provides not only an outstanding starting point for graduate students and new investigations, but a superb reference that presents intriguing new results for those already active in the field.

  9. Optimal profile modification curves for spur gears considering vibration responses of a gear-rotor system%考虑齿轮-转子系统振动响应的最佳修形曲线研究

    Institute of Scientific and Technical Information of China (English)

    马辉; 逄旭; 宋溶泽; 闻邦椿

    2015-01-01

    轮齿修形可减小齿轮静态传动误差,改善齿轮动态特性。基于现有文献,考虑基圆与齿根圆不重合,在齿廓精确建模的基础上确定齿轮的时变啮合刚度和静态传动误差。针对不同修形曲线在不同修形量下齿轮静态传动误差的变化进行分析,给出了不同修形量范围内的最佳修形曲线,并结合齿轮-转子系统动力学模型,考虑齿廓修形引起的无载荷静态传动误差,分析不同修形曲线下系统的振动特性,进一步确定不同转速下最佳修形曲线。研究结果表明通过评估齿轮-转子系统的振动特性,可更好地确定不同转速下的轮齿的最佳修形曲线。%Tooth profile modification can decrease the loaded static transmission error,and improve the dynamic characteristics of gear pairs.Here,based on available theories and literatures,the time-varying mesh stiffness (TVMS) and static transmission error (STE)were determined with a correction method considering misalign effect between the root circle and tooth base circle and an accurate gear profile curve.The optimal profile modification curves with different amounts of profile modification were determined by analyzing the STE changing with different profile modification curves and different amounts of profile modification.Combining a gear-rotor system dynamic model and considering the effect of no-load STE caused by profile modification,the vibration responses of the gear-rotor system with different gear profile modification curves were analyzed to determine the optimal profile modification curves at different rotating speeds.The results showed that the optimal gear profile modification curves at different rotating speeds can be determined by evaluating the vibration responses of the gear-rotor system.

  10. Establishment of radiation dose-response curve based on in vitro irradiation of peripheral blood samples by X-ray%离体人外周血血X射线照射后剂量效应曲线的建立

    Institute of Scientific and Technical Information of China (English)

    李广伟; 李峰生

    2012-01-01

    目的 建立准确估算受辐射照射者辐射剂量的方法.方法 采用X射线照射离体人外周血,一步法培养外周血淋巴细胞56 h后收获制片,检测染色体"双着丝粒(dic)+环(r)"畸变率,拟合剂量效应曲线.结果 畸变率随照射剂量增加而增加,存在明显的剂量效应,剂量效应曲线回归方程为y=0.020 8x2+0.102 8x-0.024 8,r2=0.995 3(P<0.05).结论 通过建立X射线照射离体人外周血后的剂量效应曲线,能准确估算受照辐射剂量.%Objective To establish the method of estimating accurately radiation dose of the individuals exposed to ionizing-radi-ation. Methods The blood samples in vitro were irradiated by X-ray,then cultured using one-step method for 56 hours. According to the chromosomal aberration rate(including dicentric chromosome and ring) , radiation dose-response curve was fitted. Results The chromosomal aberration rate induced by the different radiation doses increased along with the increase of radiation dose, and there was an apparent dose-response relationship,the radiation dose-response curve regression equation:y=0. 020 8x2+0. 102 8x-0. 024 8. Conclusion The dose of the individual exposed to ionizing-radiation could be estimated accurately according to the radiation dose-response curve that might be fitted by the blood samples in vitro irradiated by X-ray.

  11. Learning Curve? Which One?

    Directory of Open Access Journals (Sweden)

    Paulo Prochno

    2004-07-01

    Full Text Available Learning curves have been studied for a long time. These studies provided strong support to the hypothesis that, as organizations produce more of a product, unit costs of production decrease at a decreasing rate (see Argote, 1999 for a comprehensive review of learning curve studies. But the organizational mechanisms that lead to these results are still underexplored. We know some drivers of learning curves (ADLER; CLARK, 1991; LAPRE et al., 2000, but we still lack a more detailed view of the organizational processes behind those curves. Through an ethnographic study, I bring a comprehensive account of the first year of operations of a new automotive plant, describing what was taking place on in the assembly area during the most relevant shifts of the learning curve. The emphasis is then on how learning occurs in that setting. My analysis suggests that the overall learning curve is in fact the result of an integration process that puts together several individual ongoing learning curves in different areas throughout the organization. In the end, I propose a model to understand the evolution of these learning processes and their supporting organizational mechanisms.

  12. SRHA calibration curve

    Data.gov (United States)

    U.S. Environmental Protection Agency — an UV calibration curve for SRHA quantitation. This dataset is associated with the following publication: Chang, X., and D. Bouchard. Surfactant-Wrapped Multiwalled...

  13. ROBUST DECLINE CURVE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Sutawanir Darwis

    2012-05-01

    Full Text Available Empirical decline curve analysis of oil production data gives reasonable answer in hyperbolic type curves situations; however the methodology has limitations in fitting real historical production data in present of unusual observations due to the effect of the treatment to the well in order to increase production capacity. The development ofrobust least squares offers new possibilities in better fitting production data using declinecurve analysis by down weighting the unusual observations. This paper proposes a robustleast squares fitting lmRobMM approach to estimate the decline rate of daily production data and compares the results with reservoir simulation results. For case study, we usethe oil production data at TBA Field West Java. The results demonstrated that theapproach is suitable for decline curve fitting and offers a new insight in decline curve analysis in the present of unusual observations.

  14. A quantitative measurement of antiviral activity of anti-human immunodeficiency virus type 1 drugs against simian immunodeficiency virus infection: dose-response curve slope strongly influences class-specific inhibitory potential.

    Science.gov (United States)

    Deng, Kai; Zink, M Christine; Clements, Janice E; Siliciano, Robert F

    2012-10-01

    Simian immunodeficiency virus (SIV) infection in macaques is so far the best animal model for human immunodeficiency virus type 1 (HIV-1) studies, but suppressing viral replication in infected animals remains challenging. Using a novel single-round infectivity assay, we quantitated the antiviral activities of antiretroviral drugs against SIV. Our results emphasize the importance of the dose-response curve slope in determining the inhibitory potential of antiretroviral drugs and provide useful information for regimen selection in treating SIV-infected animals in models of therapy and virus eradication.

  15. Large Curved Surface Measurement

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The measurement principle of large curved surface through theodolite industry survey system is introduced. Two methods are suggested with respect to the distribution range of curved surface error. The experiments show that the measurement precision can be up to 0.15mm with relative precision of 3×10-5. Finally, something needed paying attention to and the application aspects on theodolite industry survey system are given.

  16. Counting curves on surfaces

    OpenAIRE

    2015-01-01

    In this paper we consider an elementary, and largely unexplored, combinatorial problem in low-dimensional topology. Consider a real 2-dimensional compact surface $S$, and fix a number of points $F$ on its boundary. We ask: how many configurations of disjoint arcs are there on $S$ whose boundary is $F$? We find that this enumerative problem, counting curves on surfaces, has a rich structure. For instance, we show that the curve counts obey an effective recursion, in the general framework of to...

  17. Arithmetic of Shimura curves

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This is the note for a series of lectures that the author gave at the Centre de Recerca Matemtica (CRM), Bellaterra, Barcelona, Spain on October 19–24, 2009. The aim is to give a comprehensive description of some recent work of the author and his students on generalisations of the Gross-Zagier formula, Euler systems on Shimura curves, and rational points on elliptic curves.

  18. Highly curved microchannel plates

    Science.gov (United States)

    Siegmund, O. H. W.; Cully, S.; Warren, J.; Gaines, G. A.; Priedhorsky, W.; Bloch, J.

    1990-01-01

    Several spherically curved microchannel plate (MCP) stack configurations were studied as part of an ongoing astrophysical detector development program, and as part of the development of the ALEXIS satellite payload. MCP pairs with surface radii of curvature as small as 7 cm, and diameters up to 46 mm have been evaluated. The experiments show that the gain (greater than 1.5 x 10 exp 7) and background characteristics (about 0.5 events/sq cm per sec) of highly curved MCP stacks are in general equivalent to the performance achieved with flat MCP stacks of similar configuration. However, gain variations across the curved MCP's due to variations in the channel length to diameter ratio are observed. The overall pulse height distribution of a highly curved surface MCP stack (greater than 50 percent FWHM) is thus broader than its flat counterpart (less than 30 percent). Preconditioning of curved MCP stacks gives comparable results to flat MCP stacks, but it also decreases the overall gain variations. Flat fields of curved MCP stacks have the same general characteristics as flat MCP stacks.

  19. The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope.

    Directory of Open Access Journals (Sweden)

    Shuai Chang

    Full Text Available This study was designed to identify common HIV-1 mutation complexes affecting the slope of inhibition curve, and to propose a new parameter incorporating both the IC50 and the slope to evaluate phenotypic resistance.Utilizing site-directed mutagenesis, we constructed 22 HIV-1 common mutation complexes. IC50 and slope of 10 representative approved drugs and a novel agent against these mutations were measured to determine the resistance phenotypes. The values of new parameter incorporating both the IC50 and the slope of the inhibition curve were calculated, and the correlations between parameters were assessed.Depending on the class of drug, there were intrinsic differences in how the resistance mutations affected the drug parameters. All of the mutations resulted in large increases in the IC50s of nucleoside reverse transcriptase inhibitors. The effects of the mutations on the slope were the most apparent when examining their effects on the inhibition of non-nucleoside reverse transcriptase inhibitors and protease inhibitors. For example, some mutations, such as V82A, had no effect on IC50, but reduced the slope. We proposed a new concept, termed IIPatoxic, on the basis of IC50, slope and the maximum limiting concentrations of the drug. The IIPatoxic values of 10 approved drugs and 1 novel agent were calculated, and were closely related to the IIPmax values (r > 0.95, p < 0.001.This study confirms that resistance mutations cannot be accurately assessed by IC50 alone, because it tends to underestimate the degree of resistance. The slope parameter is of very importance in the measurement of drug resistance and the effect can be applied to more complex patterns of resistance. This is the most apparent when testing the effects of the mutations on protease inhibitors activity. We also propose a new index, IIPatoxic, which incorporates both the IC50 and the slope. This new index could complement current IIP indices, thereby enabling predict the

  20. Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging and DNA Repair Processes in Shaping the Dose-Response Curve of KBrO₃-Induced DNA Damage.

    Science.gov (United States)

    Spassova, Maria A; Miller, David J; Nikolov, Alexander S

    2015-01-01

    We have developed a kinetic model to investigate how DNA repair processes and scavengers of reactive oxygen species (ROS) can affect the dose-response shape of prooxidant induced DNA damage. We used as an example chemical KBrO3 which is activated by glutathione and forms reactive intermediates that directly interact with DNA to form 8-hydroxy-2-deoxyguanosine DNA adducts (8-OH-dG). The single strand breaks (SSB) that can result from failed base excision repair of these adducts were considered as an effect downstream from 8-OH-dG. We previously demonstrated that, in the presence of effective base excision repair, 8-OH-dG can exhibit threshold-like dose-response dependence, while the downstream SSB can still exhibit a linear dose-response. Here we demonstrate that this result holds for a variety of conditions, including low levels of GSH, the presence of additional SSB repair mechanisms, or a scavenger. It has been shown that melatonin, a terminal scavenger, inhibits KBrO3-caused oxidative damage. Our modeling revealed that sustained exposure to KBrO3 can lead to fast scavenger exhaustion, in which case the dose-response shapes for both endpoints are not substantially affected. The results are important to consider when forming conclusions on a chemical's toxicity dose dependence based on the dose-response of early genotoxic events.

  1. THE GRISM LENS-AMPLIFIED SURVEY FROM SPACE (GLASS). V. EXTENT AND SPATIAL DISTRIBUTION OF STAR FORMATION IN z ∼ 0.5 CLUSTER GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Vulcani, Benedetta [Kavli Institute for the Physics and Mathematics of the Universe (WPI), The University of Tokyo Institutes for Advanced Study (UTIAS), the University of Tokyo, Kashiwa, 277-8582 (Japan); Treu, Tommaso; Malkan, Matthew; Abramson, Louis [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095-1547 (United States); Schmidt, Kasper B. [Department of Physics, University of California, Santa Barbara, CA 93106-9530 (United States); Poggianti, Bianca M. [INAF-Astronomical Observatory of Padova (Italy); Dressler, Alan [The Observatories of the Carnegie Institution for Science, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Fontana, Adriano; Pentericci, Laura [INAF—Osservatorio Astronomico di Roma, Via Frascati 33, 00040 Monte Porzio Catone (Italy); Bradac, Marusa; Hoag, Austin; Huang, Kuan-Han; He, Julie [Department of Physics, University of California, Davis, CA 95616 (United States); Brammer, Gabriel B. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Trenti, Michele [School of Physics, University of Melbourne, VIC 3010 (Australia); Linden, Anja von der [Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen Juliane Maries Vej 30, DK-2100 Copenhagen Ø (Denmark); Morris, Glenn [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, 452 Lomita Mall, Stanford, CA 94305-4085 (United States)

    2015-12-01

    We present the first study of the spatial distribution of star formation in z ∼ 0.5 cluster galaxies. The analysis is based on data taken with the Wide Field Camera 3 as part of the Grism Lens-Amplified Survey from Space (GLASS). We illustrate the methodology by focusing on two clusters (MACS 0717.5+3745 and MACS 1423.8+2404) with different morphologies (one relaxed and one merging) and use foreground and background galaxies as a field control sample. The cluster+field sample consists of 42 galaxies with stellar masses in the range 10{sup 8}–10{sup 11} M{sub ⊙} and star formation rates in the range 1–20 M{sub ⊙} yr{sup −1}. Both in clusters and in the field, Hα is more extended than the rest-frame UV continuum in 60% of the cases, consistent with diffuse star formation and inside-out growth. In ∼20% of the cases, the Hα emission appears more extended in cluster galaxies than in the field, pointing perhaps to ionized gas being stripped and/or star formation being enhanced at large radii. The peak of the Hα emission and that of the continuum are offset by less than 1 kpc. We investigate trends with the hot gas density as traced by the X-ray emission, and with the surface mass density as inferred from gravitational lens models, and find no conclusive results. The diversity of morphologies and sizes observed in Hα illustrates the complexity of the environmental processes that regulate star formation. Upcoming analysis of the full GLASS data set will increase our sample size by almost an order of magnitude, verifying and strengthening the inference from this initial data set.

  2. The Grism Lens-amplified Survey from Space (Glass). IX. The Dual Origin of Low-mass Cluster Galaxies as Revealed by New Structural Analyses

    Science.gov (United States)

    Morishita, Takahiro; Abramson, Louis E.; Treu, Tommaso; Vulcani, Benedetta; Schmidt, Kasper B.; Dressler, Alan; Poggianti, Bianca M.; Malkan, Matthew A.; Wang, Xin; Huang, Kuang-Han; Trenti, Michele; Bradač, Maruša; Hoag, Austin

    2017-02-01

    Using deep Hubble Frontier Fields imaging and slitless spectroscopy from the Grism Survey from Space, we study 2200 cluster and 1748 field galaxies at 0.2≤slant z≤slant 0.7 to determine the impact of environment on galaxy size and structure at stellar masses {log}{M}* /{M}ȯ > 7.8, an unprecedented limit at these redshifts. Based on simple assumptions—{r}e=f({M}* )—we find no significant differences in half-light radii (r e ) between equal-mass cluster or field systems. More complex analyses—{r}e=f({M}* ,U-V,n,z,{{Σ }})—reveal local density (Σ) to induce only a 7% ± 3% (95% confidence) reduction in r e beyond what can be accounted for by U ‑ V color, Sérsic index (n), and redshift (z) effects. Almost any size difference between galaxies in high- and low-density regions is thus attributable to their different distributions in properties other than environment. Indeed, we find a clear color–r e correlation in low-mass passive cluster galaxies ({log}{M}* /{M}ȯ star-forming galaxies. We take this as evidence that large-r e low-mass passive cluster galaxies are recently acquired systems that have been environmentally quenched without significant structural transformation (e.g., by ram pressure stripping or starvation). Conversely, ∼20% of small-r e low-mass passive cluster galaxies appear to have been in place since z≳ 3. Given the consistency of the small-r e galaxies’ stellar surface densities (and even colors) with those of systems more than ten times as massive, our findings suggest that clusters mark places where galaxy evolution is accelerated for an ancient base population spanning most masses, with late-time additions quenched by environment-specific mechanisms mainly restricted to the lowest masses.

  3. Extracting the normal lung dose-response curve from clinical DVH data: a possible role for low dose hyper-radiosensitivity, increased radioresistance

    Science.gov (United States)

    Gordon, J. J.; Snyder, K.; Zhong, H.; Barton, K.; Sun, Z.; Chetty, I. J.; Matuszak, M.; Ten Haken, R. K.

    2015-09-01

    In conventionally fractionated radiation therapy for lung cancer, radiation pneumonitis’ (RP) dependence on the normal lung dose-volume histogram (DVH) is not well understood. Complication models alternatively make RP a function of a summary statistic, such as mean lung dose (MLD). This work searches over damage profiles, which quantify sub-volume damage as a function of dose. Profiles that achieve best RP predictive accuracy on a clinical dataset are hypothesized to approximate DVH dependence. Step function damage rate profiles R(D) are generated, having discrete steps at several dose points. A range of profiles is sampled by varying the step heights and dose point locations. Normal lung damage is the integral of R(D) with the cumulative DVH. Each profile is used in conjunction with a damage cutoff to predict grade 2 plus (G2+) RP for DVHs from a University of Michigan clinical trial dataset consisting of 89 CFRT patients, of which 17 were diagnosed with G2+ RP. Optimal profiles achieve a modest increase in predictive accuracy—erroneous RP predictions are reduced from 11 (using MLD) to 8. A novel result is that optimal profiles have a similar distinctive shape: enhanced damage contribution from low doses (curves, which can be modeled using Joiner’s induced repair model. A novel search strategy is employed, which has the potential to estimate RP dependence on the normal lung DVH. When applied to a clinical dataset, identified profiles share a characteristic shape, which resembles HRS/IRR. This suggests that normal lung may have enhanced sensitivity to low doses, and that this sensitivity can affect RP risk.

  4. Approximation by planar elastic curves

    DEFF Research Database (Denmark)

    Brander, David; Gravesen, Jens; Nørbjerg, Toke Bjerge

    2016-01-01

    We give an algorithm for approximating a given plane curve segment by a planar elastic curve. The method depends on an analytic representation of the space of elastic curve segments, together with a geometric method for obtaining a good initial guess for the approximating curve. A gradient......-driven optimization is then used to find the approximating elastic curve....

  5. Moduli of Trigonal Curves

    CERN Document Server

    Stankova-Frenkel, Z E

    1997-01-01

    We study the moduli of trigonal curves. We establish the exact upper bound of ${36(g+1)}/(5g+1)$ for the slope of trigonal fibrations. Here, the slope of any fibration $X\\to B$ of stable curves with smooth general member is the ratio Hodge class $\\lambda$ on the moduli space $\\bar{\\mathfrak{M}}_g$ to the base $B$. We associate to a trigonal family $X$ a canonical rank two vector bundle $V$, and show that for Bogomolov-semistable $V$ the slope satisfies the stronger inequality ${\\delta_B}/{\\lambda_B}\\leq 7+{6}/{g}$. We further describe the rational Picard group of the {trigonal} locus $\\bar{\\mathfrak T}_g$ in the moduli space $\\bar{\\mathfrak{M}}_g$ of genus $g$ curves. In the even genus case, we interpret the above Bogomolov semistability condition in terms of the so-called Maroni divisor in $\\bar{\\mathfrak T}_g$.

  6. Power Curve Measurements REWS

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Vesth, Allan

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here, the refere......This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here......, the reference wind speed used in the power curve is the equivalent wind speed obtained from lidar measurements at several heights between lower and upper blade tip, in combination with a hub height meteorological mast. The measurements have been performed using DTU’s measurement equipment, the analysis...

  7. The sales learning curve.

    Science.gov (United States)

    Leslie, Mark; Holloway, Charles A

    2006-01-01

    When a company launches a new product into a new market, the temptation is to immediately ramp up sales force capacity to gain customers as quickly as possible. But hiring a full sales force too early just causes the firm to burn through cash and fail to meet revenue expectations. Before it can sell an innovative product efficiently, the entire organization needs to learn how customers will acquire and use it, a process the authors call the sales learning curve. The concept of a learning curve is well understood in manufacturing. Employees transfer knowledge and experience back and forth between the production line and purchasing, manufacturing, engineering, planning, and operations. The sales learning curve unfolds similarly through the give-and-take between the company--marketing, sales, product support, and product development--and its customers. As customers adopt the product, the firm modifies both the offering and the processes associated with making and selling it. Progress along the manufacturing curve is measured by tracking cost per unit: The more a firm learns about the manufacturing process, the more efficient it becomes, and the lower the unit cost goes. Progress along the sales learning curve is measured in an analogous way: The more a company learns about the sales process, the more efficient it becomes at selling, and the higher the sales yield. As the sales yield increases, the sales learning process unfolds in three distinct phases--initiation, transition, and execution. Each phase requires a different size--and kind--of sales force and represents a different stage in a company's production, marketing, and sales strategies. Adjusting those strategies as the firm progresses along the sales learning curve allows managers to plan resource allocation more accurately, set appropriate expectations, avoid disastrous cash shortfalls, and reduce both the time and money required to turn a profit.

  8. Algebraic curves and cryptography

    CERN Document Server

    Murty, V Kumar

    2010-01-01

    It is by now a well-known paradigm that public-key cryptosystems can be built using finite Abelian groups and that algebraic geometry provides a supply of such groups through Abelian varieties over finite fields. Of special interest are the Abelian varieties that are Jacobians of algebraic curves. All of the articles in this volume are centered on the theme of point counting and explicit arithmetic on the Jacobians of curves over finite fields. The topics covered include Schoof's \\ell-adic point counting algorithm, the p-adic algorithms of Kedlaya and Denef-Vercauteren, explicit arithmetic on

  9. Power Curve Measurements REWS

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Villanueva, Héctor

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here......, the reference wind speed used in the power curve is the equivalent wind speed obtained from lidar measurements at several heights between lower and upper blade tip, in combination with a hub height meteorological mast. The measurements have been performed using DTU’s measurement equipment, the analysis...

  10. Power curve investigation

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Vesth, Allan

    are not performed according to IEC 61400-12-1 [1]. Therefore, the results presented in this report cannot be considered a power curve according to the reference standard, and are referred to as “power curve investigation” instead. The measurements have been performed by a customer and the data analysis has been......This report describes the analysis carried out with data from a given turbine in a wind farm and a chosen period. The purpose of the analysis is to correlate the power output of the wind turbine to the wind speed measured by a nacelle-mounted anemometer. The measurements and analysis...

  11. Curves for the response of a Ge(Li) detector to gamma rays in the energy range up to 11 MeV

    DEFF Research Database (Denmark)

    Kopecký, J.; Ratyński, W.; Warming, Inge Elisabeth

    1967-01-01

    The response function of a Ge(Li) coaxial detector with a sensitive volume of 17 cm3 for gamma rays of energies ranging from 2.23 to 10.83 MeV has been determined. The measurements were carried out with an experimental set-up using the neutron beam from the DR 3 reactor ar Risö and the (n, γ......) reaction as gamma-ray source. The important features of the spectra are discussed, and the double-escape peak efficiency is determined....

  12. Paths of algebraic hyperbolic curves

    Institute of Scientific and Technical Information of China (English)

    Ya-juan LI; Li-zheng LU; Guo-zhao WANG

    2008-01-01

    Cubic algebraic hyperbolic (AH) Bezier curves and AH spline curves are defined with a positive parameter α in the space spanned by {1, t, sinht, cosht}. Modifying the value of α yields a family of AH Bezier or spline curves with the family parameter α. For a fixed point on the original curve, it will move on a defined curve called "path of AH curve" (AH Bezier and AH spline curves) when α changes. We describe the geometric effects of the paths and give a method to specify a curve passing through a given point.

  13. Nacelle lidar power curve

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Wagner, Rozenn

    This report describes the power curve measurements performed with a nacelle LIDAR on a given wind turbine in a wind farm and during a chosen measurement period. The measurements and analysis are carried out in accordance to the guidelines in the procedure “DTU Wind Energy-E-0019” [1]. The reporting...

  14. Graphs, Curves and Dynamics

    NARCIS (Netherlands)

    Kool, J.

    2013-01-01

    This thesis has three main subjects. The first subject is Measure-theoretic rigidity of Mumford Curves. One can describe isomorphism of two compact hyperbolic Riemann surfaces of the same genus by a measure-theoretic property: a chosen isomorphism of their fundamental groups corresponds to a homeomo

  15. Power Curve Measurements

    DEFF Research Database (Denmark)

    Vesth, Allan; Kock, Carsten Weber

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present anal...

  16. Power Curve Measurements

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Gómez Arranz, Paula

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  17. Power Curve Measurements FGW

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Villanueva, Héctor

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  18. Fitting a Gompertz curve

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans)

    1994-01-01

    textabstractIn this paper, a simple Gompertz curve-fitting procedure is proposed. Its advantages include the facts that the stability of the saturation level over the sample period can be checked, and that no knowledge of its value is necessary for forecasting. An application to forecasting the stoc

  19. Gompertz curves with seasonality

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans)

    1994-01-01

    textabstractThis paper considers an extension of the usual Gompertz curve by allowing the parameters to vary over the seasons. This means that, for example, saturation levels can be different over the year. An estimation and testing method is proposed and illustrated with an example.

  20. Power Curve Measurements

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Vesth, Allan

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  1. Power Curve Measurements, FGW

    DEFF Research Database (Denmark)

    Vesth, Allan; Yordanova, Ginka

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...

  2. Graphing Polar Curves

    Science.gov (United States)

    Lawes, Jonathan F.

    2013-01-01

    Graphing polar curves typically involves a combination of three traditional techniques, all of which can be time-consuming and tedious. However, an alternative method--graphing the polar function on a rectangular plane--simplifies graphing, increases student understanding of the polar coordinate system, and reinforces graphing techniques learned…

  3. Power Curve Measurements, REWS

    DEFF Research Database (Denmark)

    Villanueva, Héctor; Gómez Arranz, Paula

    This report describes the power curve measurements carried out on a given wind turbine in a chosen period. The measurements were carried out following the measurement procedure in the draft of IEC 61400-12-1 Ed.2 [1], with some deviations mostly regarding uncertainty calculation. Here, the refere...

  4. Power Curve Measurements

    DEFF Research Database (Denmark)

    Federici, Paolo; Kock, Carsten Weber

    This report describes the power curve measurements performed with a nacelle LIDAR on a given wind turbine in a wind farm and during a chosen measurement period. The measurements and analysis are carried out in accordance to the guidelines in the procedure “DTU Wind Energy-E-0019” [1]. The reporting...

  5. Straightening Out Learning Curves

    Science.gov (United States)

    Corlett, E. N.; Morecombe, V. J.

    1970-01-01

    The basic mathematical theory behind learning curves is explained, together with implications for clerical and industrial training, evaluation of skill development, and prediction of future performance. Brief studies of textile worker and typist training are presented to illustrate such concepts as the reduction fraction (a consistent decrease in…

  6. Carbon Lorenz Curves

    NARCIS (Netherlands)

    Groot, L.F.M.

    The purpose of this paper is twofold. First, it exhibits that standard tools in the measurement of income inequality, such as the Lorenz curve and the Gini-index, can successfully be applied to the issues of inequality measurement of carbon emissions and the equity of abatement policies across

  7. Power Curve Measurements

    DEFF Research Database (Denmark)

    Kock, Carsten Weber; Federici, Paolo

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...... analyze of power performance of the turbine....

  8. Power Curve Measurements, FGW

    DEFF Research Database (Denmark)

    Kock, Carsten Weber; Vesth, Allan

    The report describes power curve measurements carried out on a given wind turbine. The measurements are carried out in accordance to Ref. [1]. A site calibration has been carried out; see Ref. [2], and the measured flow correction factors for different wind directions are used in the present...... analyze of power performance of the turbine....

  9. Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action.

    Science.gov (United States)

    Vaidya, A H; Rosenthal, D I; Lang, W; Crooke, J J; Benjamin, D; Ilyin, S E; Reitz, A B

    2005-05-01

    Most studies concerning the effects of oral buspirone in the rat elevated plus-maze (EPM) test, spontaneous motor activity (SMA) test, and Vogel conflict (VC) test have used Sprague-Dawley or Wistar rats. Although it has been documented that the behavior of Long-Evans rats is more sensitive to detection of anxiolytics when compared to the aforementioned strains, the effects of oral buspirone have not been fully characterized in the Long-Evans strain in the EPM and VC tests. Thus, we studied the effects of orally administered buspirone (0.03-10.0 mg/kg) in the EPM, SMA, and VC (0.3-60.0 mg/kg) tests in Long-Evans rats. In a separate experiment, brain and plasma concentrations of buspirone and 1-(2-pyrimidinyl)-piperazine (1-PP) were determined after oral administration of buspirone (0.3 and 10 mg/kg) to relate the behavioral effects of buspirone with brain and plasma concentrations of buspirone and 1-PP. Our results showed that buspirone exhibited an inverted-U-shaped dose-response curve in both the EPM and the VC tests. In the EPM, buspirone produced anxiolytic activity in a low, narrow dose-range (0.03, 0.1, 0.3 mg/kg, p.o.) with maximum efficacy at 0.3 mg/kg, whereas in the VC test, significant anxiolytic activity was observed in a high, narrow dose-range (10, 30 mg/kg, p.o.) with maximum efficacy occurring at 10 mg/kg. In the SMA test, buspirone (10 mg/kg, p.o.) significantly decreased horizontal activity and vertical movements suggestive of sedation. Also, one hour following oral doses of buspirone (0.3 and 10 mg/kg), both buspirone and 1-PP concentrations were higher in brain when compared with those in plasma. Additionally, the concentrations of 1-PP were always higher in brain and in plasma compared with the concentrations of buspirone. Of particular interest is our finding of the shift in the dose-response curve between the EPM and VC tests. This shift in the dose-response curve is discussed in relation to brain levels of buspirone and 1-PP levels and their

  10. Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients

    DEFF Research Database (Denmark)

    Bouteloup, V; Sabin, C; Mocroft, A

    2017-01-01

    OBJECTIVES: The aim of this work was to provide a reference for the CD4 T-cell count response in the early months after the initiation of combination antiretroviral therapy (cART) in HIV-1-infected patients. METHODS: All patients in the Collaboration of Observational HIV Epidemiological Research...... Europe (COHERE) cohort who were aged ≥ 18 years and started cART for the first time between 1 January 2005 and 1 January 2010 and who had at least one available measurement of CD4 count and a viral load ≤ 50 HIV-1 RNA copies/mL at 6 months (± 3 months) after cART initiation were included in the study...... and 12 months were 382 (IQR 256, 515), 402 (IQR 274, 543) and 420 (IQR 293, 565) cells/μL. The two main factors explaining the variation of CD4 count at 6 months were AIDS stage and CD4 count at cART initiation. A CD4 count increase of ≥ 100 cells/mL is generally required in order that patients stay 'on...

  11. Foot-and-mouth disease vaccine potency testing: the influence of serotype, type of adjuvant, valency, fractionation method, and virus culture on the dose-response curve in cattle.

    Science.gov (United States)

    Jamal, Syed M; Bouma, Annemarie; van den Broek, Jan; Stegeman, Arjan; Chénard, Gilles; Dekker, Aldo

    2008-11-25

    The aim of this study was to determine a relationship between vaccine potency (amount of PD50 per dose) and fraction of clinically protected cattle following homologous challenge with infectious foot-and-mouth disease (FMD) virus, and to determine the effect of method of fractionation, serotype, type of adjuvant, valency and type of virus culture on the dose-response curve. Data from 297 potency tests of FMD vaccines, comprising 4004 vaccinated cattle, performed at the FMD vaccine production facility in the Netherlands, were used for the present study. A generalised linear mixed effect model was used to analyse the results. Our study showed that the relation between FMD vaccine potency and fraction protected was also affected by the serotype and type of adjuvant. No common level of protection could be assigned to all FMD vaccines with the same amount of PD50 per dose, this information is essential when designing a new standard FMD vaccines control.

  12. Carbon Lorenz Curves

    Energy Technology Data Exchange (ETDEWEB)

    Groot, L. [Utrecht University, Utrecht School of Economics, Janskerkhof 12, 3512 BL Utrecht (Netherlands)

    2008-11-15

    The purpose of this paper is twofold. First, it exhibits that standard tools in the measurement of income inequality, such as the Lorenz curve and the Gini-index, can successfully be applied to the issues of inequality measurement of carbon emissions and the equity of abatement policies across countries. These tools allow policy-makers and the general public to grasp at a single glance the impact of conventional distribution rules such as equal caps or grandfathering, or more sophisticated ones, on the distribution of greenhouse gas emissions. Second, using the Samuelson rule for the optimal provision of a public good, the Pareto-optimal distribution of carbon emissions is compared with the distribution that follows if countries follow Nash-Cournot abatement strategies. It is shown that the Pareto-optimal distribution under the Samuelson rule can be approximated by the equal cap division, represented by the diagonal in the Lorenz curve diagram.

  13. Managing curved canals

    Directory of Open Access Journals (Sweden)

    Iram Ansari

    2012-01-01

    Full Text Available Dilaceration is the result of a developmental anomaly in which there has been an abrupt change in the axial inclination between the crown and the root of a tooth. Dilaceration can be seen in both the permanent and deciduous dentitions, and is more commonly found in posterior teeth and in maxilla. Periapical radiographs are the most appropriate way to diagnose the presence of root dilacerations. The controlled regularly tapered preparation of the curved canals is the ultimate challenge in endodontics. Careful and meticulous technique will yield a safe and sufficient enlargement of the curved canals. This article gives a review of the literature and three interesting case reports of root dilacerations.

  14. LCC: Light Curves Classifier

    Science.gov (United States)

    Vo, Martin

    2017-08-01

    Light Curves Classifier uses data mining and machine learning to obtain and classify desired objects. This task can be accomplished by attributes of light curves or any time series, including shapes, histograms, or variograms, or by other available information about the inspected objects, such as color indices, temperatures, and abundances. After specifying features which describe the objects to be searched, the software trains on a given training sample, and can then be used for unsupervised clustering for visualizing the natural separation of the sample. The package can be also used for automatic tuning parameters of used methods (for example, number of hidden neurons or binning ratio). Trained classifiers can be used for filtering outputs from astronomical databases or data stored locally. The Light Curve Classifier can also be used for simple downloading of light curves and all available information of queried stars. It natively can connect to OgleII, OgleIII, ASAS, CoRoT, Kepler, Catalina and MACHO, and new connectors or descriptors can be implemented. In addition to direct usage of the package and command line UI, the program can be used through a web interface. Users can create jobs for ”training” methods on given objects, querying databases and filtering outputs by trained filters. Preimplemented descriptors, classifier and connectors can be picked by simple clicks and their parameters can be tuned by giving ranges of these values. All combinations are then calculated and the best one is used for creating the filter. Natural separation of the data can be visualized by unsupervised clustering.

  15. Dynamics of curved fronts

    CERN Document Server

    Pelce, Pierre

    1989-01-01

    In recent years, much progress has been made in the understanding of interface dynamics of various systems: hydrodynamics, crystal growth, chemical reactions, and combustion. Dynamics of Curved Fronts is an important contribution to this field and will be an indispensable reference work for researchers and graduate students in physics, applied mathematics, and chemical engineering. The book consist of a 100 page introduction by the editor and 33 seminal articles from various disciplines.

  16. Estimating Corporate Yield Curves

    OpenAIRE

    Antionio Diaz; Frank Skinner

    2001-01-01

    This paper represents the first study of retail deposit spreads of UK financial institutions using stochastic interest rate modelling and the market comparable approach. By replicating quoted fixed deposit rates using the Black Derman and Toy (1990) stochastic interest rate model, we find that the spread between fixed and variable rates of interest can be modeled (and priced) using an interest rate swap analogy. We also find that we can estimate an individual bank deposit yield curve as a spr...

  17. Atypical Light Curves

    CERN Document Server

    Steenwyk, Steven D; Molnar, Lawrence A

    2013-01-01

    We have identified some two-hundred new variable stars in a systematic study of a data archive obtained with the Calvin-Rehoboth observatory. Of these, we present five close binaries showing behaviors presumably due to star spots or other magnetic activity. For context, we first present two new RS CVn systems whose behavior can be readily attribute to star spots. Then we present three new close binary systems that are rather atypical, with light curves that are changing over time in ways not easily understood in terms of star spot activity generally associated with magnetically active binary systems called RS CVn systems. Two of these three are contact binaries that exhibit gradual changes in average brightness without noticeable changes in light curve shape. A third system has shown such large changes in light curve morphology that we speculate this may be a rare instance of a system that transitions back and forth between contact and noncontact configurations, perhaps driven by magnetic cycles in at least o...

  18. Application of normalized time-frequency response spectrum and structural damage curve%归一化时-频反应谱与结构损伤曲线的应用

    Institute of Scientific and Technical Information of China (English)

    邱志刚; 罗奇峰

    2013-01-01

    In order to investigate the application of normalized time-frequency response spectrum and structural damage curve, a 10-storey reinforced concrete frame structure subjected to Tianjin record (SN direction) in Tangshan earthquake and ChiChi record (SN direction) whose seismic characteristics are completely different is studied by using elastoplastic time-history analysis. The performances of structural damage curves of the two cases on normalized time-frequency response spectrums are compared. The results show that the maximum seismic response of structures may not always result in the maximum damage, but the subsequent small seismic response may lead to the overall collapse of structures. Aseismatic design with unreasonable seismic record is not reliable. Therefore, there are some limitations in traditional response spectrum theory. Structural damage curve, which can reflect plastic development of structures through variations of structural natural vibration periods, together with normalized time-frequency response spectrum which contains the three features of earthquake motions (amplitude, frequency and duration) can effectively predict structural damage mechanism, which provides reference basis for aseismatic design of structures subjected to severe earthquake.%为了研究归一化时-频反应谱和结构损伤曲线在抗震设计中的应用价值,对某十层RC框架结构采用地震动特性截然不同的唐山地震天津波SN方向和集集地震波SN方向进行弹塑性时程分析,对比了2种工况下结构损伤曲线在地震波归一化时-频反应谱上的表现.结果表明,结构的最大地震反应并不一定造成结构最大破坏,而随后很小的反应也可能最终导致结构倒塌,选用不合理的地震记录进行抗震设计是不可靠的,故传统的反应谱理论存在一定的局限性.结构损伤曲线通过自振周期的变化可以反映结构的塑性发展,与同时具备地震动三要素(振幅、频谱和持

  19. Fitting Analysis for 4 Photosynthesis Light Response Curve Models of Keteleeria calcarea%4种模型对黄枝油杉光合光响应曲线的拟合分析

    Institute of Scientific and Technical Information of China (English)

    柴胜丰; 唐健民; 杨雪; 谢伟玲; 韦霄; 蒋运生

    2015-01-01

    [Objective]In order to find the best photosynthesis light response curve model and obtain a more accurate photosynthetic parameters,the photosynthetic characteristics of Keteleeria calcarea was studied.[Methods]The photosynthesis light response curve was measured using the Li - 6400 portable photosynthesis system.4 light response curve models,including rectangular hyperbolic model, non-rectangular hyperbolic model,exponential model and modified rectangular hyperbolic mod-el,were applied to fitting its light response curve.[Results]According to calculated photo-synthetic parameters by 4 models,maximum net photosynthetic rate (Pnmax)estimated by rectan-gular hyperbola and non-rectangular hyperbola model were higher than that measured by exper-iment,while Pnmax fitted by exponential model and modified rectangular hyperbolic model were similar with that measured by experiment.Isat estimated by rectangular hyperbolic model,non-rectangular hyperbolic model and exponential model were far lower than the measured data,only Isat estimated by modified rectangular hyperbolic model was the closest to the measured data.The modified rectangular hyperbola model was the best model for fitting photosynthesis light response curve of Keteleeria calcarea.The Pnmax,Isat,Ic (compensation point)andRd(respiration rate)were 5.06μmol·m-2·s-1,850.45μmol·m-2·s-1,7.86μmol·m-2·s-1 and 0.816 μmol·m-2 ·s-1,respectively.[Conclusion]According to the relative errors of measured and fitted values of photosynthesis light response parameters,the sequence of fitting effect of the four light response models in descending order was modified rectangular hyperbola model > exponential model > non-rectangular hyperbola model >rectangular hyperbola model.%【目的】为找出黄枝油杉(Keteleeriacalcarea)光合光响应曲线的最佳模型,以得到较为准确的光合特征参数。【方法】采用 Li-6400便携式光合系统对黄枝油杉的光合光响应曲线进行测定,并通过4

  20. 癫痫患者顺式阿曲库铵的剂量反应曲线测定%The measurement of dose-response curve of cisatracurium in epilepsy patients

    Institute of Scientific and Technical Information of China (English)

    刘中杰; 徐世元; 张庆国; 梁启波; 曾繁荣

    2011-01-01

    Objective To determine the dose-response curve and the ED95 of cisatracurium in epilepsy patients. Methods Forty ASA grade Ⅰ or Ⅱ epilepsy patients were randomly divided into four groups. The dose-response curve was determined by single bolus injection of cisatracurium under midazolam-fentanyl intravenous anesthesia. For each group, the dose of cisatracurium were 20,30, 40 and 50 μg/kg respectively. The neuromuscular block was measured by Neuromuscular Transmission Monitor, and the responses were defined in terms of the percentages of maximum suppression in T1 of TOF of the adductor pollicis muscle. After logprobit transformation of the data of dose and response, the dose-response curve of cisatracurium was then established by linear regression. The onset time of cisatracurium was also recorded. Results The ED50, ED75, ED90 and ED95 of cisatracurium in epilepsy patients were 36.3, 46.1, 57.4 and 65.4 μg/kg. There was no significant change in onset time among 4 groups. Conclusion The ED95 of cisatracurium in epilepsy patients is 65.4 μg/kg, which is about 30.8% higher than that in normal human.%目的 采用单次剂量注射法建立癫痫患者顺式阿曲库铵的剂量反应曲线,确定其量效关系及ED95,为癫痫患者合理应用顺式阿曲库铵提供依据.方法 选取择期癫痫手术患者40例,ASA Ⅰ~Ⅱ级,年龄16岁~42岁,病史3年~26年,均具有服用抗癫痫药物史,术前无酸碱平衡及水电解质紊乱,心肺、肝肾功能正常.患者按随机数字法分为20μg/kg组、30μg/kg组、40 μg/kg组、50μg/kg组共4个剂量组,每组10例.记录拇内收肌四个成串刺激反应中第1次反应最大抑制的百分率,并进行概率单位转换,将顺式阿曲库铵的首次剂量进行对数转换,用直线回归方法建立顺式阿曲库铵的剂量-反应曲线,并记录起效时间.结果 癫痫患者顺式阿曲库铵ED50、ED75、ED90、ED95值分别为36.3、46.1、57.4、65.4μg/kg,起效时间在4个剂

  1. The Dust Attenuation Curve versus Stellar Mass for Emission Line Galaxies at z ~ 2

    CERN Document Server

    Zeimann, Gregory R; Gronwall, Caryl; Bridge, Joanna; Brooks, Hunter; Fox, Derek; Gawiser, Eric; Gebhardt, Henry; Hagen, Alex; Schneider, Donald P; Trump, Jonathan R

    2015-01-01

    We derive the mean wavelength dependence of stellar attenuation in a sample of 239 high redshift (1.90 < z < 2.35) galaxies selected via Hubble Space Telescope (HST) WFC3 IR grism observations of their rest-frame optical emission lines. Our analysis indicates that the average reddening law follows a form similar to that derived by Calzetti et al. for local starburst galaxies. However, over the mass range 7.2 < log M/Msolar < 10.2, the slope of the attenuation law in the UV is shallower than that seen locally, and the UV slope steepens as the mass increases. These trends are in qualitative agreement with Kriek & Conroy, who found that the wavelength dependence of attenuation varies with galaxy spectral type. However, we find no evidence of an extinction "bump" at 2175 A in any of the three stellar mass bins, or in the sample as a whole. We quantify the relation between the attenuation curve and stellar mass and discuss its implications.

  2. 光合作用对胞间和大气CO_2响应曲线的比较%A comparison of response curves of winter wheat photosynthesis to flag leaf intercellular and air CO_2 concentrations

    Institute of Scientific and Technical Information of China (English)

    叶子飘; 于强

    2009-01-01

    By using Li-6400 portable photosynthesis system, the photosynthetic parameters of winter wheat (Triticum aestivum) during its heading stage in North China Plain were measured at air temperature 25℃ and 30℃ and at photosynthetically available radiation 1500 and 2000 mmol·m~(-2)·s~(-1). The measured data were fitted with the modified rectangular hyperbola models of the photosynthetic responses to flag leaf intercellular CO_2 concentration (A/C_i) and air CO_2 concentration (A/C_a), aimed to approach the reasonability of the fitted results obtained from the models. The photosynthetic capacity and CO_2 compensation point estimated by the modified A/C_i curve and A/C_a curve were nearly the same, but the photorespiration and initial earboxylation ef-ficiency estimated by them were completely different. The difference between the two modified curves came from the calculated but not the real intercellular CO_2 concentration. Modified A/C_a curve was more reasonable than the modified A/C_i curve, because the photorespiration rate esti-mated by the former was close to the measured value.%利用Li-6400便携式光合作用系统测定华北平原冬小麦在温度为25℃和30℃、光合有效辐射为1500和2000 mmol·m~(-2)·s~(-1)条件下处于抽穗时期旗叶的CO_2响应曲线,研究植物光合作用对胞间CO_2响应(A/C_i)和对大气CO_2响应(A/C_a)的直角双曲线修正模型所给拟合结果的合理性.结果表明:由A/C_i和A/C_a修正模型所给的光合能力和CO_2补偿点几乎相同,但得到的光呼吸速率和初始羧化效率则完全不等;产生这种差异的原因是利用叶片气体交换测定的数据所计算的胞间CO_2浓度并不是植物叶片本身的胞间CO_2浓度;A/C_a修正模型比A/C_i修正模型更为合理是因为A/C_a所估算的光呼吸速率接近测量值.

  3. Ef fect of Shading on the Photosynthesis Diurnal Variation Curves and Phot osynthetic Active Radiation-Net Photo-synthetic Rate Response Curves of Polygonatum odoratum%遮光对玉竹光合日变化和光合有效辐射-净光合速率响应曲线的影响

    Institute of Scientific and Technical Information of China (English)

    李璟; 叶充; 蔡仕珍; 廖源林

    2015-01-01

    Using Li-6400 photosynthesis system , we measured the photosynthesis diurnal variation curves and photosynthetic ac -tive radiation (Par)-net photosynthetic rate (Pn) response curves of Polygonatum odoratum in four shading treatments with shading rate 40%, 70%, 85%and 98%.The Pn diurnal variation curves of Polygonatum odoratum showed two peaks , and we observed obvious midday depression of photosynthesis , which was mainly affected by stomatal limitation factors .The Pn maximum all day was shading rate 70%and the minimum was shading rate 98%.The Par-Pn response curve of Polygona-tum odoratum with four shading treatment was rapidly rising-smooth change-decline.The curves showed that when Par was lower than 600μmol· m-2· s-1, Pn in shading rate of 70%was highest, followed by 40%, the minimum was shading rate of 98%, while Par was higher than 600μmol· m-2· s-1, Pn in shading rate of 40%was highest, followed by 70%, and the minimum was 98%.The light compensation point , light saturation point , the dark respiration rate , quantum efficiency , photosynthetic capacity showed that Polygonatum odoratum in shading rate of 70%had higher photosynthetic accumulation ability with the minimum light compensation point , the maximum quantum efficiency and lower dark respiration rate , while it in shading rate of 40%had the highest light saturation point , the maximum photosynthetic capacity , and higher light compensation point , the highest dark respiration rate , lower quantum efficiency .Polygonatum odoratum in shading rate of 98%had the highest light compensation point and the minimum light saturation point , quantum efficiency and photosyn-thetic capacity.Therefore, Polygonatum odoratum cultivation in the shading rate of 70%was more appropriate, and the shading stress of shading rate of 98%was its negative growth .%用Li-6400光合系统测定了遮阳率40%、70%、85%和98%4种遮光处理下玉竹的光合日变化曲线和光合有效辐射( Par

  4. Curved PVDF airborne transducer.

    Science.gov (United States)

    Wang, H; Toda, M

    1999-01-01

    In the application of airborne ultrasonic ranging measurement, a partially cylindrical (curved) PVDF transducer can effectively couple ultrasound into the air and generate strong sound pressure. Because of its geometrical features, the ultrasound beam angles of a curved PVDF transducer can be unsymmetrical (i.e., broad horizontally and narrow vertically). This feature is desired in some applications. In this work, a curved PVDF air transducer is investigated both theoretically and experimentally. Two resonances were observed in this transducer. They are length extensional mode and flexural bending mode. Surface vibration profiles of these two modes were measured by a laser vibrometer. It was found from the experiment that the surface vibration was not uniform along the curvature direction for both vibration modes. Theoretical calculations based on a model developed in this work confirmed the experimental results. Two displacement peaks were found in the piezoelectric active direction of PVDF film for the length extensional mode; three peaks were found for the flexural bending mode. The observed peak positions were in good agreement with the calculation results. Transient surface displacement measurements revealed that vibration peaks were in phase for the length extensional mode and out of phase for the flexural bending mode. Therefore, the length extensional mode can generate a stronger ultrasound wave than the flexural bending mode. The resonance frequencies and vibration amplitudes of the two modes strongly depend on the structure parameters as well as the material properties. For the transducer design, the theoretical model developed in this work can be used to optimize the ultrasound performance.

  5. Magnetism in curved geometries

    Science.gov (United States)

    Streubel, Robert; Fischer, Peter; Kronast, Florian; Kravchuk, Volodymyr P.; Sheka, Denis D.; Gaididei, Yuri; Schmidt, Oliver G.; Makarov, Denys

    2016-09-01

    Extending planar two-dimensional structures into the three-dimensional space has become a general trend in multiple disciplines, including electronics, photonics, plasmonics and magnetics. This approach provides means to modify conventional or to launch novel functionalities by tailoring the geometry of an object, e.g. its local curvature. In a generic electronic system, curvature results in the appearance of scalar and vector geometric potentials inducing anisotropic and chiral effects. In the specific case of magnetism, even in the simplest case of a curved anisotropic Heisenberg magnet, the curvilinear geometry manifests two exchange-driven interactions, namely effective anisotropy and antisymmetric exchange, i.e. Dzyaloshinskii-Moriya-like interaction. As a consequence, a family of novel curvature-driven effects emerges, which includes magnetochiral effects and topologically induced magnetization patterning, resulting in theoretically predicted unlimited domain wall velocities, chirality symmetry breaking and Cherenkov-like effects for magnons. The broad range of altered physical properties makes these curved architectures appealing in view of fundamental research on e.g. skyrmionic systems, magnonic crystals or exotic spin configurations. In addition to these rich physics, the application potential of three-dimensionally shaped objects is currently being explored as magnetic field sensorics for magnetofluidic applications, spin-wave filters, advanced magneto-encephalography devices for diagnosis of epilepsy or for energy-efficient racetrack memory devices. These recent developments ranging from theoretical predictions over fabrication of three-dimensionally curved magnetic thin films, hollow cylinders or wires, to their characterization using integral means as well as the development of advanced tomography approaches are in the focus of this review.

  6. 拟Timmer曲线%Timmer-like curve

    Institute of Scientific and Technical Information of China (English)

    汪志华; 戴林送; 陈素根; 苏本跃

    2014-01-01

    The cubic Timmer curve can interpolate the midpoint of the intermediate control edge of the control polygon, however, it can not tangent the control edge. And the cubic Timmer curve does not possess the convex hull property. In response to these flaws, this paper proposes one kind of curve(call it Timmer-like curve). The Timmer-like curve not only possesses some properties as the Timmer curve, but possesses the convex hull property, interpolates the midpoint of the second control edge of the control polygon, and the second control edge tangents the midpoint of the second control edge of the control polygon.%三次Timmer曲线能够插值的控制多边形中间控制边的中点,但它却不能保证与该控制边相切,且三次Tim-mer曲线不具有凸包性。针对于此,提出了一类曲线(称之拟Timmer曲线),拟Timmer曲线不仅具有与Timmer曲线所类似的性质,而且具有凸包性,且能够插值中间控制边的中点,并与之相切。

  7. Superfluids in Curved Spacetime

    CERN Document Server

    Villegas, Kristian Hauser A

    2015-01-01

    Superfluids under an intense gravitational field are typically found in neutron star and quark star cores. Most treatments of these superfluids, however, are done in a flat spacetime background. In this paper, the effect of spacetime curvature on superfluidity is investigated. An effective four-fermion interaction is derived by integrating out the mediating scalar field. The fermions interacting via the mediating gauge vector bosons is also discussed. Two possible cases are considered in the mean-field treatment: antifermion-fermion and fermion-fermion pairings. An effective action, quadratic in fermion field, and a self-consistent equation are derived for both cases. The effective Euclidean action and the matrix elements of the heat kernel operator, which are very useful in curved-spacetime QFT calculations, are derived for the fermion-fermion pairing. Finally, explicit numerical calculation of the gravitational correction to the pairing order parameter is performed for the scalar superfluid case. It is foun...

  8. Polymers in Curved Boxes

    CERN Document Server

    Yaman, K; Solis, F J; Witten, T A

    1996-01-01

    We apply results derived in other contexts for the spectrum of the Laplace operator in curved geometries to the study of an ideal polymer chain confined to a spherical annulus in arbitrary space dimension D and conclude that the free energy compared to its value for an uncurved box of the same thickness and volume, is lower when $D < 3$, stays the same when $D = 3$, and is higher when lowers the effective bending elasticity of the walls, and might induce spontaneous symmetry breaking, i.e. bending. (Actually, the above mentioned results show that {\\em {any}} shell in $D = 3$ induces this effect, except for a spherical shell). We compute the contribution of this effect to the bending rigidities in the Helfrich free energy expression.

  9. Evolutes of Hyperbolic Plane Curves

    Institute of Scientific and Technical Information of China (English)

    Shyuichi IZUMIYA; Dong He PEI; Takashi SANO; Erika TORII

    2004-01-01

    We define the notion of evolutes of curves in a hyperbolic plane and establish the relationships between singularities of these subjects and geometric invariants of curves under the action of the Lorentz group. We also describe how we can draw the picture of an evolute of a hyperbolic plane curve in the Poincar(e) disk.

  10. The Arithmetic of Elliptic Curves

    CERN Document Server

    Silverman, Joseph H

    2009-01-01

    Treats the arithmetic theory of elliptic curves in its modern formulation, through the use of basic algebraic number theory and algebraic geometry. This book discusses the necessary algebro-geometric results, and offers an exposition of the geometry of elliptic curves, and the formal group of an elliptic curve.

  11. Curved-Duct

    Directory of Open Access Journals (Sweden)

    Je Hyun Baekt

    2000-01-01

    Full Text Available A numerical study is conducted on the fully-developed laminar flow of an incompressible viscous fluid in a square duct rotating about a perpendicular axis to the axial direction of the duct. At the straight duct, the rotation produces vortices due to the Coriolis force. Generally two vortex cells are formed and the axial velocity distribution is distorted by the effect of this Coriolis force. When a convective force is weak, two counter-rotating vortices are shown with a quasi-parabolic axial velocity profile for weak rotation rates. As the rotation rate increases, the axial velocity on the vertical centreline of the duct begins to flatten and the location of vorticity center is moved near to wall by the effect of the Coriolis force. When the convective inertia force is strong, a double-vortex secondary flow appears in the transverse planes of the duct for weak rotation rates but as the speed of rotation increases the secondary flow is shown to split into an asymmetric configuration of four counter-rotating vortices. If the rotation rates are increased further, the secondary flow restabilizes to a slightly asymmetric double-vortex configuration. Also, a numerical study is conducted on the laminar flow of an incompressible viscous fluid in a 90°-bend square duct that rotates about axis parallel to the axial direction of the inlet. At a 90°-bend square duct, the feature of flow by the effect of a Coriolis force and a centrifugal force, namely a secondary flow by the centrifugal force in the curved region and the Coriolis force in the downstream region, is shown since the centrifugal force in curved region and the Coriolis force in downstream region are dominant respectively.

  12. Soil Water Retention Curve

    Science.gov (United States)

    Johnson, L. E.; Kim, J.; Cifelli, R.; Chandra, C. V.

    2016-12-01

    Potential water retention, S, is one of parameters commonly used in hydrologic modeling for soil moisture accounting. Physically, S indicates total amount of water which can be stored in soil and is expressed in units of depth. S can be represented as a change of soil moisture content and in this context is commonly used to estimate direct runoff, especially in the Soil Conservation Service (SCS) curve number (CN) method. Generally, the lumped and the distributed hydrologic models can easily use the SCS-CN method to estimate direct runoff. Changes in potential water retention have been used in previous SCS-CN studies; however, these studies have focused on long-term hydrologic simulations where S is allowed to vary at the daily time scale. While useful for hydrologic events that span multiple days, the resolution is too coarse for short-term applications such as flash flood events where S may not recover its full potential. In this study, a new method for estimating a time-variable potential water retention at hourly time-scales is presented. The methodology is applied for the Napa River basin, California. The streamflow gage at St Helena, located in the upper reaches of the basin, is used as the control gage site to evaluate the model performance as it is has minimal influences by reservoirs and diversions. Rainfall events from 2011 to 2012 are used for estimating the event-based SCS CN to transfer to S. As a result, we have derived the potential water retention curve and it is classified into three sections depending on the relative change in S. The first is a negative slope section arising from the difference in the rate of moving water through the soil column, the second is a zero change section representing the initial recovery the potential water retention, and the third is a positive change section representing the full recovery of the potential water retention. Also, we found that the soil water moving has traffic jam within 24 hours after finished first

  13. Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.

    Science.gov (United States)

    Luszczki, Jarogniew J; Filip, Damian; Czuczwar, Stanislaw J

    2010-10-01

    The aim of this study was to characterize the anticonvulsant effects of pregabalin (PGB-a third-generation antiepileptic drug) in combination with three second-generation antiepileptic drugs (i.e., lamotrigine [LTG], oxcarbazepine [OXC] and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs). Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25mA, 500V, 50Hz, 0.2s stimulus duration) delivered via auricular electrodes. Potential adverse-effect profiles of interactions of PGB with LTG, OXC and TPM at the fixed-ratio of 1:1 in the MES test with respect to motor performance, long-term memory and skeletal muscular strength were measured. In the mouse MES model, PGB administered singly had its DRRC non-parallel to that for LTG, OXC and TPM. With type I isobolography for non-parallel DRRCs, the combinations of PGB with LTG, OXC and TPM at the fixed-ratio of 1:1 exerted additive interaction. In all combinations, neither motor coordination, long-term memory nor muscular strength were affected. In conclusion, the additive interactions between PGB and LTG, OXC and TPM are worthy of consideration while extrapolating the results from this study to clinical settings.

  14. Understanding outliers on the usual dose-response curve: venlafaxine as a way to phenotype patients in terms of their CYP 2D6 status and why it matters.

    Science.gov (United States)

    Preskorn, Sheldon H

    2010-01-01

    Venlafaxine is a model substrate for the drug metabolizing cytochrome P450 (CYP) enzyme 2D6. The desvenlafaxine/venlafaxine ratio, either after a single dose or at steady state, can be used to determine whether a patient is functionally (i.e., phenotypically) a CYP 2D6 extensive or poor metabolizer (EM or PM). In turn, CYP 2D6 EM and PM status is important in determining the efficacy of venlafaxine as an antidepressant. Based on a secondary analysis of four of the venlafaxine registration trials, venlafaxine was effective in patients who were CYP 2D6 EMs versus a parallel placebo-treated control group, whereas it was not effective in patients who were CYP 2D6 PMs. Thus, venlafaxine is a useful example of how drugs can be used to quantify differences in drug metabolizing capacity among patients and how such differences can in turn affect the efficacy of a drug (i.e., make a patient an outlier on the usual dose-response curve).

  15. 5种光响应模型对小叶杨的适用性分析%The applicability analysis of five light response curves of photosynthesis in Populus simonii

    Institute of Scientific and Technical Information of China (English)

    宋佩东

    2015-01-01

    采用Li-6400光合仪测定CO2400μmol·mol-1条件下小叶杨的光响应数据。分别采用直角双曲线修正模型、二次多项式模型、直角双曲线模型、非直角双曲线模型及指数模型对光响应曲线进行拟合,探讨5种模型对小叶杨的适用性。结果表明:直角双曲线、非直角双曲线及指数模型不能处理光抑制部分的光响应数据,且得到的最大净光合速率大于实测值,光饱和点远小于实测值;二次多项式虽能处理光抑制部分的光响应数据,但得到的光合参数有悖常识;直角双曲线修正模型不仅能处理光抑制部分的光响应数据,且拟合得到的各项光合参数均与实际相符,是拟合小叶杨光响应曲线的最适宜模型。%The light response data of Populus simonii were measured by Li-6400 at concentration of CO2 400μmol·mol-1.Modified rectangular hyperbola model,quadratic polynomial model,rectangular hyperbola model,non-rectangular hyperbola model and expo-nential model were used to fit the light response curves of Populus simonii,and the applicability of these five models to the Populus si⁃monii were discussed. The results indicated that rectangular hyperbola model,non-rectangular hyperbola model and exponential mod-el were incapable of dealing with the light response data of photoinhibition,and the calculated maximum net photosynthetic rates were bigger than the measured value,besides,the the calculated light saturation points were far lower than the measured;Although, the quadratic polynomial model can process data of photoinhibition,the resulting photosynthetic parameters were contrary to com-mon sense;Rectangular hyperbola model not only could process light response data under photoinhibition,but also could get photo-synthetic parameters which was conformity with reality.

  16. Cubic B-spline curve approximation by curve unclamping

    OpenAIRE

    Chen, Xiao-Diao; Ma, Weiyin; Paul, Jean-Claude

    2010-01-01

    International audience; A new approach for cubic B-spline curve approximation is presented. The method produces an approximation cubic B-spline curve tangent to a given curve at a set of selected positions, called tangent points, in a piecewise manner starting from a seed segment. A heuristic method is provided to select the tangent points. The first segment of the approximation cubic B-spline curve can be obtained using an inner point interpolation method, least-squares method or geometric H...

  17. 不同温度对钩栗光响应曲线拟合的影响%Effect of temperature on light response curve fitting of Castanopsis tibetana

    Institute of Scientific and Technical Information of China (English)

    张斌; 罗小浪

    2016-01-01

    Measuring and fitting the light response curve is one of the widely used methods when we cultivate the precious trees species. But as the difference among models and the genetic characters of tree species, the application of light response model is very important in the research of precious tree. The research were done in 2 years old seedlings of precious timber tree species of Castanopsis tibetana, using LI-6400 photosynthesis system to measure the photosynthesic characteristics of Castanopsis tibetana, compare 5 different light response models for the fitting of the characteristic data of the combination at 25℃ and 45℃ , the results show: high temperature stress can enhance the ability of using weak light, and also significantly reduced the maximum net photosynthetic capacity; under normal temperature (25 ℃ ) the value of modified rectangular hyperbolic model (MRHM) is higher by 12.99% - 30.57% compare to other models and measured value, while higher by 12.44% - 26.91% under higher temperature (45℃ ); compare all the models, under 25℃ , exponential model (EM), and modified exponential model (MEM) and non-rectangular hyperbolic model (NHM) have the best fitting effect, but under the condition of 45℃ , NHM and EM are the best models; Compere the real value and parameters of photosynthetic curve, NHM is the best model without the influence of temperature.%以珍贵用材树种钩栗2年生幼苗为研究对象,采用 LI-6400光合速率测试仪对钩栗成熟叶片的光合能力进行测定分析,在对钩栗25℃和45℃条件下的光合特征曲线进行拟合后发现5个模型间存在不同程度的差异。高温胁迫提高了钩栗对弱光的利用能力,也显著降低了钩栗的最大净光合能力;从模型的拟合效果来看,直角双曲线修正模型在常温时的模拟值与实际值和其他模型相比高出12.99%~30.57%,而在高温条件下却高出12.44%~26.91%,拟合效果最差;常温条件下指数模

  18. Curvas dose-resposta em espécies de plantas daninhas com o uso do herbicida glyphosate(1 Dose-response curves in weed species with the use of herbicide glyphosate

    Directory of Open Access Journals (Sweden)

    André Luiz de Souza Lacerda

    2004-01-01

    . The herbicide glyphosate, inhibitor of the enzyme EPSPs, was used at rate 0.0; 11.3; 22.5; 45; 90; 180; 360; 720 and 1440 g.ha-1 a.i. Curves of dose-response were made by the adjustment of the equation of the collected data of green biomass using the log-logistic model: Y = C+D-C / 1 + Exp{b[log(x-log(RC50]}, calculated by the no linear statistical model through the SAS statistical program. After the determination of the dose-response curves for the species mentioned above the Bidens pilosa was considered the most susceptible weed to glyphosate, showing the houvest RC50 (31.86 g.ha-1 a.i.. The species Tridax procumbens, Digitaria insularis, Spermacoce latifolia, Ipomoea grandifolia and Commelina benghalensis obtained RC50 equal to 58.40; 128.50; 250.44; 615.49 and > 1440.00 g.ha-1 a.i., respectively, what means that the necessary amount of herbicide to reduce in 50% the green biomass was 1.83; 4.03; 7.86; 19.31 and >359.56 times higher in relation the Bidens pilosa.

  19. The measurement of dose-response curve of cisatracurium in patients with end-stage renal disease%终末期肾病患者顺式阿曲库铵量效关系测定

    Institute of Scientific and Technical Information of China (English)

    葛彦虎; 王宏月; 刘秀珍; 王恒林; 张斌; 王卓强

    2013-01-01

    目的 采用单次剂量注射法测定终末期肾病患者顺式阿曲库铵量效关系. 方法 选取接受肾移植的终末期肾病患者40例,按完全随机方法分为4组,每组10例,对4个剂量组患者按体重注射20、30、40、50 μg/kg的顺式阿曲库铵.选取无神经肌肉病变的患者20例作为对照组,给予相同剂量的苯磺酸顺式阿曲库铵.记录每个患者最大抑制效应,并对最大抑制效应进行概率转换,对应的肌松药剂量进行对数转换,用直线回归方法建立顺式阿曲库铵的剂量-反应曲线. 结果 终末期肾病患者顺式阿曲库铵50%有效剂量(ED50) 、75%有效剂量(ED75)、90%有效剂量(ED90)、95%有效剂量ED95分别为30.88、35.65、40.62、43.85 μg/kg,无神经肌肉病变患者顺式阿曲库铵ED50、ED75、ED90、ED95分别为35.37、42.22、49.60、54.55 μg/kg,终末期肾病患者顺式阿曲库铵ED95明显低于无神经肌肉病变患者ED95 (P<0.01). 结论 终末期肾病患者因周围神经病变累及神经肌肉接头可导致对肌松药的敏感性增加.%Objective To determine the dose-response curve of cisatracurium in patients with end-stage renal disease.Methods Forty patients with end stage renal disease were randomly divided into four groups(n=10),the dose of cisatracurium were 20,30,40 or 50 μg/kg respectively.Twenty patients with normal neural and muscular function were randomly divided into four groups and received the same doses pattern.The dose-response curve was determined by single bolus of cisatracurium under midazolam-fentanyl intravenous anesthesia.Neuromuscular transmission monitoring was used to measure the block effect after injection of cisatracurium,and the responses were defined by terms of the percentages of maximum suppression in twitch response 1 of train of four of the adductor policies muscle.After logarithmic transformation,the dose-response curve of cisatracurium was then established by linear analysis

  20. 不同性别癫痫患者维库溴铵剂量-反应曲线的测定%Investigating the dose-response curves of vecuronium in different gender epilepsy patients

    Institute of Scientific and Technical Information of China (English)

    刘中杰; 张庆国; 卢爱珠; 赖露颖; 李乐; 徐世元

    2015-01-01

    Objective To evaluate the gender differences in dose-response curve of vecuronium in epilepsy patients and provide a reference for its individualized application.Methods Hundred ASA grade Ⅰ-Ⅱ epilepsy patients were enrolled in this study.All patients were divided into male group (group M) and female group (group F)(n=50),they recieved the method of single dose injection under midazolam-fentanyl intravenous anesthesia.Every patient received intravenous single bolus of 20,30,40,50,60 μg/kg of vecuronium respectively(n=l0).The neuromuscular block was measured by neuromuscular transmission monitor and the responses were defined in terms of the percentages of maximum suppression in T1 of train of four stimulation (TOF) of the adductor pollicis muscle.According to log-probit transformation of the data of dose and response,the dose-response curve of vecuronium was established through linear regression.The onset time of vecuronium was also observed.Results The 50% effective dose (ED50),75% effective dose (ED75),90% effective dose (ED90),95% effective dose (ED95) values of vecuronium in male epilepsy patients were (31±6),(40±8),(50±9),(57±7) μg/kg.The ED50,ED75,ED90,ED95 values of vecuronium in female epilepsy patients were(31±6),(40±7),(50±9),(58±9) μg/kg.No significant difference in onset time was observed among 5 dose groups (P>0.05).Conclusions There was no gender difference in dose-response curve of vecuronium in epilepsy patients.%目的 研究性别对癫痫患者维库溴铵量效关系的影响,为维库溴铵个体化应用提供参考. 方法 选取择期癫痫手术患者100例,美国麻醉医师协会(ASA)分级Ⅰ~Ⅱ级,年龄19岁~4l岁,病史2年~23年,分为男性组(M组)与女性组(F组),每组各50例,均有服用抗癫痫药物史,术前无酸碱平衡及水电解质紊乱,心、肺、肝、肾功能正常.每组患者按随机数字表法分为20、30、40、50、60 μg/kg 5个剂量组,每组10例.记录拇

  1. 不同性别癫痫患者顺式阿曲库铵剂量-反应曲线的测定%Investigating the dose-response curves of cisatracurium in the different gender epileptics

    Institute of Scientific and Technical Information of China (English)

    刘中杰; 张庆国; 李乐; 卢爱珠; 赖露颖; 徐世元

    2014-01-01

    Objective To evaluate the gender differences in dose-response curve with cisatra-curium in epileptics.Methods Eighty ASA grade Ⅰ or Ⅱ epileptics were enrolled in this study.All patients were divided into male and the female groups and received the method of single dose injection under midazolam-fentanyl intravenous anesthesia.Each patient received intravenous bolus of 20,30, 40,50μg/kg of cisatracurium respectively.The neuromuscular block was measured by Neuromuscular Transmission Monitor and the responses were defined in terms of the percentages of maximum sup-pression in T1 of TOF of the adductor pollicis muscle.According to log-probit transformation of the data of dose and response,the dose-response curve of cisatracurium was established through linear re-gression.The onset time of cisatracurium was also observed.Results The ED50 ,ED75 ,ED90 ,ED95 values of cisatracurium in male epilepsy patients were 37.2±9.7,48.1±11.3,60.4±12.8,69.3± 14.0 μg/kg and that of female epilepsy patients were 36.6±4.3,47.5±7.7,60.5±14.0,70.1± 19.4 μg/kg.There was no significant difference between the two gender groups.No significant change in onset time was observed among 4 dose groups.Conclusion No gender differences are ob-served in dose-response curve of cisatracurium in epileptics.%目的:研究性别对癫痫手术患者顺式阿曲库铵剂量-反应曲线的影响。方法选取择期癫痫手术患者80例,年龄17~42岁,病史3~26年,分为男性组(M 组)和女性组(F 组),每组按20、30、40、50μg/kg 再分为四个亚组(M1~M4组和 F1~F4组),每组10例。记录拇内收肌四个成串刺激(TOF)第一次反应最大抑制的百分率,并进行概率单位转换,将顺式阿曲库铵的首次剂量进行对数转换,用直线回归方法分别建立男、女患者顺式阿曲库铵剂量-反应曲线,并记录起效时间。结果M组顺式阿曲库铵单次剂量静注 ED50、ED75、ED90、ED95

  2. 葡萄光合作用光响应曲线拟合模型比较研究%Comparison of Light-response Curve Fitted Models for Grape

    Institute of Scientific and Technical Information of China (English)

    白云岗; 刘洪波; 张江辉; 冯杰; 丁平

    2016-01-01

    The optimal model with the most closeness between measured and simulated value was selected.In order to find the best photo-response model of grape leaf in Turpan area,the photosynthetic response curve of grape leaf was fitted by quadratic polynomi-al,rectangular hyperbolic,exponential,rectangular hyperbolic,non-rectangular hyperbolic and modified rectangular hyperbolic mod-el.Showed that the exponential and rectangular hyperbolic model could not explain the photosynthetic suppress phenomenon of light saturation region.To some extent,the quadratic polynomial model displayed photosynthetic suppress phenomenon,but it had a very large difference between simulated photosynthetic parameters and measured ones,which defied common sense.The non-rectangular hyperbolic model explained the photosynthetic suppress phenomenon,but the fitted maximum net photosynthetic rate was higher than the measured values.The modified rectangular hyperbolic model with the most closeness between simulated value photosynthet-ic parameters and measured ones could best reflect the photosynthetic response curve for grape leaf under different light intensities, especially at the light saturation region.Whose fitted net photosynthetic rate (Amax),light saturation point (LSP),light compensa-tion point (LCP),dark respiration rate (Rday)and the initial quantum efficiency (α)was 10.627,1 178.362,67.487,2.943μmol/(m2 ·s)and 0.05.The modified rectangular hyperbolic model is suit to simulate the photosynthetic response curve for grape leaf un-der different light intensities at Turpan area.%通过分析各模型求取的光合参数模拟值与实测值的接近程度,探讨了各模型在葡萄光响应曲线研究中的适用性。为了筛选适合吐鲁番地区的葡萄光响应模型,采用二次多项式模型、指数函数模型、直角双曲线模型、非直角双曲线模型和修正的直角双曲线模型对葡萄光合作用的光响应曲线进行拟合,表明:指数函数模型

  3. Reflection of curved shock waves

    Science.gov (United States)

    Mölder, S.

    2017-03-01

    Shock curvatures are related to pressure gradients, streamline curvatures and vorticity in flows with planar and axial symmetry. Explicit expressions, in an influence coefficient format, are used to relate post-shock pressure gradient, streamline curvature and vorticity to pre-shock gradients and shock curvature in steady flow. Using higher order, von Neumann-type, compatibility conditions, curved shock theory is applied to calculate the flow near singly and doubly curved shocks on curved surfaces, in regular shock reflection and in Mach reflection. Theoretical curved shock shapes are in good agreement with computational fluid dynamics calculations and experiment.

  4. Reflection of curved shock waves

    Science.gov (United States)

    Mölder, S.

    2017-09-01

    Shock curvatures are related to pressure gradients, streamline curvatures and vorticity in flows with planar and axial symmetry. Explicit expressions, in an influence coefficient format, are used to relate post-shock pressure gradient, streamline curvature and vorticity to pre-shock gradients and shock curvature in steady flow. Using higher order, von Neumann-type, compatibility conditions, curved shock theory is applied to calculate the flow near singly and doubly curved shocks on curved surfaces, in regular shock reflection and in Mach reflection. Theoretical curved shock shapes are in good agreement with computational fluid dynamics calculations and experiment.

  5. Heegner modules and elliptic curves

    CERN Document Server

    Brown, Martin L

    2004-01-01

    Heegner points on both modular curves and elliptic curves over global fields of any characteristic form the topic of this research monograph. The Heegner module of an elliptic curve is an original concept introduced in this text. The computation of the cohomology of the Heegner module is the main technical result and is applied to prove the Tate conjecture for a class of elliptic surfaces over finite fields; this conjecture is equivalent to the Birch and Swinnerton-Dyer conjecture for the corresponding elliptic curves over global fields.

  6. Closed planar curves without inflections

    CERN Document Server

    Ohno, Shuntaro; Umehara, Masaaki

    2011-01-01

    We define a computable topological invariant $\\mu(\\gamma)$ for generic closed planar regular curves $\\gamma$, which gives an effective lower bound for the number of inflection points on a given generic closed planar curve. Using it, we classify the topological types of locally convex curves (i.e. closed planar regular curves without inflections) whose numbers of crossings are less than or equal to five. Moreover, we discuss the relationship between the number of double tangents and the invariant $\\mu(\\gamma)$ on a given $\\gamma$.

  7. Effect of different nitrogen supply on light-response curves of Quercus variabilis seedlings%不同供氮水平对栓皮栎播种苗光响应曲线的影响

    Institute of Scientific and Technical Information of China (English)

    杨自立; 马履一; 贾忠奎; 王梓

    2011-01-01

    In order to provide a theoretical foundation for nitrogen fertilizer management of Quercus variabilis seedlings,using exponential nitrogen fertilization regimes,the effects of nitrogen treatments on light-response curves of Q.variabilis seedlings were studied under sand-cultured condition.The seedlings were planted in pots,supplied with four nitrogen application levels(0,120.6,216.4 and 329.2 mg/(seedling·year)).The results show that various nitrogen application levels had different effects on the light-response curves of Q.variabilis leaves,depending on the growth phases.At the initiation phase,all the simulation parameters of light-response curves showed no significant differences among treatments.At the fast-growth phase,the lack of nitrogen weakened the photosynthetic capability of seedlings in treatment CK(0 mg/(seedling·year)) sharply,which reduced the light saturation point(LSP),maximum net photosynthetic rate(Pmax) and the apparent quantum efficiency(α);meanwhile,the light compensation point(LCP) expressed a trend of increase.When the nitrogen level was raised from 120.6 to 216.4 mg/(seedling·year),no significant variation about Pmax was found between the two treatments;however,the LCP of the seedlings in 216.4 mg/(seedling·year) treatment was lower and the LSP was higher.Yet,excessive nitrogen supply(329.2 mg/(seedling·year)) played a negative role on the photosynthetic ability of Q.variabilis seedlings.At the later phase,relatively higher photosynthetic efficiency was maintained in the seedlings in 216.4 mg/(seedling·year) treatment,comparing with the common decline in other three treatments.%为科学制定栓皮栎播种苗氮肥管理措施,在砂培条件下,采用指数施肥的试验方法,设置4个供氮水平(0、120.6、216.4和329.2mg/(株·a)),探求不同的供氮水平对栓皮栎播种苗光响应特征曲线的影响。结果表明,在苗木生长的不同阶段,供氮量

  8. The Strength-Interval Curve in Cardiac Tissue

    Directory of Open Access Journals (Sweden)

    Sunil M. Kandel

    2013-01-01

    Full Text Available The bidomain model describes the electrical properties of cardiac tissue and is often used to simulate the response of the heart to an electric shock. The strength-interval curve summarizes how refractory tissue is excited. This paper analyzes calculations of the strength-interval curve when a stimulus is applied through a unipolar electrode. In particular, the bidomain model is used to clarify why the cathodal and anodal strength-interval curves are different, and what the mechanism of the “dip” in the anodal strength-interval curve is.

  9. Migration and the Wage Curve:

    DEFF Research Database (Denmark)

    Brücker, Herbert; Jahn, Elke J.

      Based on a wage curve approach we examine the labor market effects of migration in Germany. The wage curve relies on the assumption that wages respond to a change in the unemployment rate, albeit imperfectly. This allows one to derive the wage and employment effects of migration simultaneously...

  10. NURBS curve blending using extension

    Institute of Scientific and Technical Information of China (English)

    Yong-jin LIU; Rong-qi QIU; Xiao-hui LIANG

    2009-01-01

    Curve and surface blending is an important operation in CAD systems, in which a non-uniform rational B-spline (NURBS) has been used as the de facto standard. In local comer blending, two curves intersecting at that comer are first made disjoint, and then the third blending curve is added-in to smoothly join the two curves with G1-or G2-continuity. In this paper we present a study to solve the joint problem based on curve extension. The following nice properties of this extension algorithm are exploited in depth: (1) The parameterization of the original shapes does not change; (2) No additional fragments are created.Various examples are presented to demonstrate that our solution is simple and efficient.

  11. Equations of hyperelliptic Shimura curves

    CERN Document Server

    Molina, Santiago

    2010-01-01

    We describe an algorithm that computes explicit models of hyperelliptic Shimura curves attached to an indefnite quaternion algebra over Q and Atkin-Lehner quotients of them. It exploits Cerednik-Drinfeld's non-archimedean uniformisation of Shimura curves, a formula of Gross and Zagier for the endomorphism ring of Heegner points over Artinian rings and the connection between Ribet's bimodules and the specialization of Heegner points. As an application, we provide a list of equations of Shimura curves and quotients of them obtained by our algorithm that had been conjectured by Kurihara.

  12. Poiseuille flow in curved spaces

    CERN Document Server

    Debus, J -D; Succi, S; Herrmann, H J

    2015-01-01

    We investigate Poiseuille channel flow through intrinsically curved (campylotic) media, equipped with localized metric perturbations (campylons). To this end, we study the flux of a fluid driven through the curved channel in dependence of the spatial deformation, characterized by the campylon parameters (amplitude, range and density). We find that the flux depends only on a specific combination of campylon parameters, which we identify as the average campylon strength, and derive a universal flux law for the Poiseuille flow. For the purpose of this study, we have improved and validated our recently developed lattice Boltzmann model in curved space by considerably reducing discrete lattice effects.

  13. Normal origamis of Mumford curves

    CERN Document Server

    Kremer, Karsten

    2010-01-01

    An origami (also known as square-tiled surface) is a Riemann surface covering a torus with at most one branch point. Lifting two generators of the fundamental group of the punctured torus decomposes the surface into finitely many unit squares. By varying the complex structure of the torus one obtains easily accessible examples of Teichm\\"uller curves in the moduli space of Riemann surfaces. The p-adic analogues of Riemann surfaces are Mumford curves. A p-adic origami is defined as a covering of Mumford curves with at most one branch point, where the bottom curve has genus one. A classification of all normal non-trivial p-adic origamis is presented and used to calculate some invariants. These can be used to describe p-adic origamis in terms of glueing squares.

  14. String networks as tropical curves

    CERN Document Server

    Ray, Koushik

    2008-01-01

    A prescription for obtaining supergravity solutions for planar (p,q)-string networks is presented, based on earlier results. It shows that networks may be looked upon as tropical curves emerging as the spine of the amoeba of a holomorphic curve in M-theory. The Kaehler potential of supergravity is identified with the corresponding Ronkin function. Implications of this identification in counting dyons is discussed.

  15. Growth curves for Laron syndrome.

    OpenAIRE

    Laron, Z; Lilos, P; Klinger, B.

    1993-01-01

    Growth curves for children with Laron syndrome were constructed on the basis of repeated measurements made throughout infancy, childhood, and puberty in 24 (10 boys, 14 girls) of the 41 patients with this syndrome investigated in our clinic. Growth retardation was already noted at birth, the birth length ranging from 42 to 46 cm in the 12/20 available measurements. The postnatal growth curves deviated sharply from the normal from infancy on. Both sexes showed no clear pubertal spurt. Girls co...

  16. Flow over riblet curved surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Loureiro, J B R; Freire, A P Silva, E-mail: atila@mecanica.ufrj.br [Mechanical Engineering Program, Federal University of Rio de Janeiro (COPPE/UFRJ), C.P. 68503, 21.941-972, Rio de Janeiro, RJ (Brazil)

    2011-12-22

    The present work studies the mechanics of turbulent drag reduction over curved surfaces by riblets. The effects of surface modification on flow separation over steep and smooth curved surfaces are investigated. Four types of two-dimensional surfaces are studied based on the morphometric parameters that describe the body of a blue whale. Local measurements of mean velocity and turbulence profiles are obtained through laser Doppler anemometry (LDA) and particle image velocimetry (PIV).

  17. Linear Systems on Tropical Curves

    CERN Document Server

    Haase, Christian; Yu, Josephine

    2009-01-01

    A tropical curve \\Gamma is a metric graph with possibly unbounded edges, and tropical rational functions are continuous piecewise linear functions with integer slopes. We define the complete linear system |D| of a divisor D on a tropical curve \\Gamma analogously to the classical counterpart. We investigate the structure of |D| as a cell complex and show that linear systems are quotients of tropical modules, finitely generated by vertices of the cell complex. Using a finite set of generators, |D| defines a map from \\Gamma to a tropical projective space, and the image can be extended to a tropical curve of degree equal to \\deg(D). The tropical convex hull of the image realizes the linear system |D| as a polyhedral complex. We show that curves for which the canonical divisor is not very ample are hyperelliptic. We also show that the Picard group of a \\Q-tropical curve is a direct limit of critical groups of finite graphs converging to the curve.

  18. The Grism lens-amplified survey from space (GLASS). VII. The diversity of the distribution of star formation in cluster and field galaxies at 0.3

    CERN Document Server

    Vulcani, Benedetta; Schmidt, Kasper B; Morishita, Takahiro; Dressler, Alan; Poggianti, Bianca M; Abramson, Louis; Bradač, Marusa; Brammer, Gabriel B; Hoag, Austin; Malkan, Matthew; Pentericci, Laura; Trenti, Michele

    2016-01-01

    Exploiting the slitless spectroscopy taken as part of the Grism Lens-Amplified Survey from Space (GLASS), we present an extended analysis of the spatial distribution of star formation in 76 galaxies in 10 clusters at 0.3< z <0.7. We use 85 foreground and background galaxies in the same redshift range as a field sample. The samples are well matched in stellar mass (10^8-10^11 M_sun) and star formation rate (0.5-50 M_sun/yr). We visually classify galaxies in terms of broad-band morphology, Halpha morphology and likely physical process acting on the galaxy. Most Halpha emitters have a spiral morphology (41+/-8% in clusters, 51+/-8% in the field), followed by mergers/interactions (28+/-8%, 31+/-7%, respectively) and early-type galaxies (remarkably as high as 29+/-8% in clusters and 15+/-6% in the field). A diversity of Halpha morphologies is detected, suggesting a diversity of physical processes. In clusters, 30+/-8% of the galaxies present a regular morphology, mostly consistent with star formation diffuse...

  19. The Grism Lens-Amplified Survey from Space (GLASS) X. Sub-kpc resolution gas-phase metallicity maps at cosmic noon behind the Hubble Frontier Fields cluster MACS1149.6+2223

    CERN Document Server

    Wang, Xin; Treu, Tommaso; Morishita, Takahiro; Abramson, Louis E; Brammer, Gabriel B; Huang, Kuang-Han; Malkan, Matthew A; Schmidt, Kasper B; Fontana, Adriano; Grillo, Claudio; Henry, Alaina L; Karman, Wouter; Kelly, Patrick L; Mason, Charlotte A; Mercurio, Amata; Rosati, Piero; Sharon, Keren; Trenti, Michele; Vulcani, Benedetta

    2016-01-01

    (Abridged) We combine deep HST grism spectroscopy with a new Bayesian method to derive maps of gas-phase metallicity, nebular dust extinction, and star-formation rate for 10 star-forming galaxies at high redshift ($1.2

  20. Curve Digitizer – A software for multiple curves digitizing

    Directory of Open Access Journals (Sweden)

    Florentin ŞPERLEA

    2010-06-01

    Full Text Available The Curve Digitizer is software that extracts data from an image file representing a graphicand returns them as pairs of numbers which can then be used for further analysis and applications.Numbers can be read on a computer screen stored in files or copied on paper. The final result is adata set that can be used with other tools such as MSEXCEL. Curve Digitizer provides a useful toolfor any researcher or engineer interested in quantifying the data displayed graphically. The image filecan be obtained by scanning a document

  1. Curvas de dose-resposta para avaliação do controle de fluxos de emergência de plantas daninhas pelo herbicida imazapic Dose-response curves to evaluate the control of weed emergence fluxes by imazapic

    Directory of Open Access Journals (Sweden)

    S.J.P. Carvalho

    2005-09-01

    Full Text Available O objetivo deste trabalho foi avaliar o controle de dois fluxos de emergência das plantas daninhas capim-marmelada (Brachiaria plantaginea e capim-colchão (Digitaria horizontalis pelo herbicida imazapic, aplicado em condição de pré-emergência, por meio de curvas de dose-resposta. O delineamento experimental foi o de blocos ao acaso, com quatro repetições; cada parcela constou de um vaso de 3 L de capacidade, preenchido com solo argiloso, acrescido de sementes de capim-marmelada e capim-colchão. Sendo D a dose recomendada do imazapic (140 g ha-1, os tratamentos foram: 4D, 2D, D, 1/2D, 1/4D, 1/8D, 1/16D e ausência do herbicida. Foram realizadas avaliações visuais de controle aos 30 e 60 dias após a infestação (DAI e de massa seca aos 60 DAI. Após a colheita da biomassa resultante do primeiro fluxo de emergência presente nas parcelas, os vasos foram novamente semeados com as plantas daninhas e foram realizadas novas avaliações de controle aos 30 e 60 dias após reinfestação (DAR e de massa seca aos 60 DAR. A partir dos resultados obtidos, pode-se afirmar que: o imazapic inibiu o desenvolvimento de ambas as plantas daninhas, alcançando resultados superiores a 80% de controle em todas as avaliações, para a dose recomendada, nos dois fluxos de emergência; a eficácia no controle de capim-colchão foi ligeiramente superior à do controle do capim-marmelada; e o herbicida imazapic apresentou-se como uma opção interessante para manejo dessas plantas daninhas.The objective of this work was to evaluate the control of two emergence fluxes of the weeds Brachiaria plantaginea and Digitaria horizontalis by the herbicide imazapic applied under pre-emergence conditions, by analyzing the dose-response curves. The experimental design adopted was randomized blocks, with four replicates, with each plot being a 3L capacity pot, filled with clay soil plus Brachiaria plantaginea and Digitaria horizontalis seeds. Considering D as the

  2. Model fitting on fight response curve of photosynthesis of wild Drepanostachyum luodianense%野生小蓬竹的光合光响应曲线及其模型拟合

    Institute of Scientific and Technical Information of China (English)

    廖小锋; 刘济明; 张东凯; 靳勇; 张勇; 闫国华; 王敏

    2012-01-01

    Several typical models of light-response curve of leaf net photosynthesis, such as non-rectangular hyperbolic model, rectangular hyperbolic model, prompted rectangular hyperbolic model and index function model, were tested on wild Drepanostachyum luodianense, and the applicability of these models also were investigated. The results were summarized as follows: ① the plant' t analytical solution of maximum net photosynmetic rate (Pnmax) and saturation point (Isat) couldn' t be solved by rectangular hyperbola model, non-rectangular hyperbola model and exponential equation model, while the values simulated by combining other methods existed a big difference compared with the measured value, and the data under photoinhibition couldn' t be processed by these three models; ② the quadratic polynomial model could process the data under photoinhibition to a certain extent, but the photosynthetic parameters simulated by it also existed larger difference compared with the measured value, even generated logic error, ③ the photosynthetic parameters simulated by modified rectangular hyperbola model all were close to the measured values ,and this model also could well process the data under photoinhibition; ④ the Pnmax, Isat compensation point(Ic), respiration rate(Rd) and initial quantum efticiency(a) of wild D. luodianense simulated by modified rectangular hyperbola model were 8.53 μmol·m-2s-1, 1 750.75 μmol·m-2s-1, 21.40 μmol·m-2s-1, 1.06 μmol·m-2s-1 and 0.054 respectively.%应用5种典型的光响应模型对野生小蓬竹叶片光响应曲线进行了拟合,并探讨了几种模型在光响应研究中的适用性.结果表明:①直角双曲线、非直角双曲线及指数函数模型无法求取植物最大净光合速率(Pnmax)和光饱和点(Isat)的解析解,而结合其它方法拟合的相应值却与实测值相差很大,同时也不能处理光抑制部分的光响应数据;②二次多项式模型能够一定程度地处理光抑制部分的光

  3. Topological recursion and mirror curves

    CERN Document Server

    Bouchard, Vincent

    2012-01-01

    We study the constant contributions to the free energies obtained through the topological recursion applied to the complex curves mirror to toric Calabi-Yau threefolds. We show that the recursion reproduces precisely the corresponding Gromov-Witten invariants, which can be encoded in powers of the MacMahon function. As a result, we extend the scope of the "remodeling conjecture" to the full free energies, including the constant contributions. In the process we study how the pair of pants decomposition of the mirror curves plays an important role in the topological recursion. We also show that the free energies are not, strictly speaking, symplectic invariants, and that the recursive construction of the free energies does not commute with certain limits of mirror curves.

  4. Laffer Curves and Home Production

    Directory of Open Access Journals (Sweden)

    Kotamäki Mauri

    2017-06-01

    Full Text Available In the earlier related literature, consumption tax rate Laffer curve is found to be strictly increasing (see Trabandt and Uhlig (2011. In this paper, a general equilibrium macro model is augmented by introducing a substitute for private consumption in the form of home production. The introduction of home production brings about an additional margin of adjustment – an increase in consumption tax rate not only decreases labor supply and reduces the consumption tax base but also allows a substitution of market goods with home-produced goods. The main objective of this paper is to show that, after the introduction of home production, the consumption tax Laffer curve exhibits an inverse U-shape. Also the income tax Laffer curves are significantly altered. The result shown in this paper casts doubt on some of the earlier results in the literature.

  5. Rational points on elliptic curves

    CERN Document Server

    Silverman, Joseph H

    2015-01-01

    The theory of elliptic curves involves a pleasing blend of algebra, geometry, analysis, and number theory. This book stresses this interplay as it develops the basic theory, thereby providing an opportunity for advanced undergraduates to appreciate the unity of modern mathematics. At the same time, every effort has been made to use only methods and results commonly included in the undergraduate curriculum. This accessibility, the informal writing style, and a wealth of exercises make Rational Points on Elliptic Curves an ideal introduction for students at all levels who are interested in learning about Diophantine equations and arithmetic geometry. Most concretely, an elliptic curve is the set of zeroes of a cubic polynomial in two variables. If the polynomial has rational coefficients, then one can ask for a description of those zeroes whose coordinates are either integers or rational numbers. It is this number theoretic question that is the main subject of this book. Topics covered include the geometry and ...

  6. Canonical curves with low apolarity

    CERN Document Server

    Ballico, Edoardo; Notari, Roberto

    2010-01-01

    Let $k$ be an algebraically closed field and let $C$ be a non--hyperelliptic smooth projective curve of genus $g$ defined over $k$. Since the canonical model of $C$ is arithmetically Gorenstein, Macaulay's theory of inverse systems allows to associate to $C$ a cubic form $f$ in the divided power $k$--algebra $R$ in $g-2$ variables. The apolarity of $C$ is the minimal number $t$ of linear form in $R$ needed to write $f$ as sum of their divided power cubes. It is easy to see that the apolarity of $C$ is at least $g-2$ and P. De Poi and F. Zucconi classified curves with apolarity $g-2$ when $k$ is the complex field. In this paper, we give a complete, characteristic free, classification of curves $C$ with apolarity $g-1$ (and $g-2$).

  7. Curved spacetimes in the lab

    CERN Document Server

    Szpak, Nikodem

    2014-01-01

    We present some new ideas on how to design analogue models of quantum fields living in curved spacetimes using ultra-cold atoms in optical lattices. We discuss various types of static and dynamical curved spacetimes achievable by simple manipulations of the optical setup. Examples presented here contain two-dimensional spaces of positive and negative curvature as well as homogeneous cosmological models and metric waves. Most of them are extendable to three spatial dimensions. We mention some interesting phenomena of quantum field theory in curved spacetimes which might be simulated in such optical lattices loaded with bosonic or fermionic ultra-cold atoms. We also argue that methods of differential geometry can be used, as an alternative mathematical approach, for dealing with realistic inhomogeneous optical lattices.

  8. The New Keynesian Phillips Curve

    DEFF Research Database (Denmark)

    Ólafsson, Tjörvi

    This paper provides a survey on the recent literature on the new Keynesian Phillips curve: the controversies surrounding its microfoundation and estimation, the approaches that have been tried to improve its empirical fit and the challenges it faces adapting to the open-economy framework. The new...... Keynesian Phillips curve has been severely criticized for poor empirical dynamics. Suggested improvements involve making some adjustments to the standard sticky price framework, e.g. introducing backwardness and real rigidities, or abandoning the sticky price model and relying on models of inattentiveness......, learning or state-dependant pricing. The introduction of openeconomy factors into the new Keynesian Phillips curve complicate matters further as it must capture the nexus between price setting, inflation and the exchange rate. This is nevertheless a crucial feature for any model to be used for inflation...

  9. Algebraic curves of maximal cyclicity

    Science.gov (United States)

    Caubergh, Magdalena; Dumortier, Freddy

    2006-01-01

    The paper deals with analytic families of planar vector fields, studying methods to detect the cyclicity of a non-isolated closed orbit, i.e. the maximum number of limit cycles that can locally bifurcate from it. It is known that this multi-parameter problem can be reduced to a single-parameter one, in the sense that there exist analytic curves in parameter space along which the maximal cyclicity can be attained. In that case one speaks about a maximal cyclicity curve (mcc) in case only the number is considered and of a maximal multiplicity curve (mmc) in case the multiplicity is also taken into account. In view of obtaining efficient algorithms for detecting the cyclicity, we investigate whether such mcc or mmc can be algebraic or even linear depending on certain general properties of the families or of their associated Bautin ideal. In any case by well chosen examples we show that prudence is appropriate.

  10. Shock detachment from curved wedges

    Science.gov (United States)

    Mölder, S.

    2017-03-01

    Curved shock theory is used to show that the flow behind attached shocks on doubly curved wedges can have either positive or negative post-shock pressure gradients depending on the freestream Mach number, the wedge angle and the two wedge curvatures. Given enough wedge length, the flow near the leading edge can choke to force the shock to detach from the wedge. This local choking can preempt both the maximum deflection and the sonic criteria for shock detachment. Analytical predictions for detachment by local choking are supported by CFD results.

  11. Shock detachment from curved wedges

    Science.gov (United States)

    Mölder, S.

    2017-09-01

    Curved shock theory is used to show that the flow behind attached shocks on doubly curved wedges can have either positive or negative post-shock pressure gradients depending on the freestream Mach number, the wedge angle and the two wedge curvatures. Given enough wedge length, the flow near the leading edge can choke to force the shock to detach from the wedge. This local choking can preempt both the maximum deflection and the sonic criteria for shock detachment. Analytical predictions for detachment by local choking are supported by CFD results.

  12. Caloric Curves and Nuclear Expansion

    CERN Document Server

    Natowitz, J B; Ma, Y; Murray, M; Qin, L; Shlomo, S; Wada, R; Wang, J

    2002-01-01

    Nuclear caloric curves have been analyzed using an expanding Fermi gas hypothesis to extract average nuclear densities. In this approach the observed flattening of the caloric curves reflects progressively increasing expansion with increasing excitation energy. This expansion results in a corresponding decrease in the density and Fermi energy of the excited system. For nuclei of medium to heavy mass apparent densities $~0.3\\rho_0$ are reached at the higher excitation energies. The average densities derived in this manner are in good agreement with those derived using other, more complicated, techniques.

  13. Curved branes with regular support

    Energy Technology Data Exchange (ETDEWEB)

    Antoniadis, Ignatios [Sorbonne Universites, LPTHE, UMR CNRS 7589, Paris (France); University of Bern, Albert Einstein Center for Fundamental Physics, ITP, Bern (Switzerland); Cotsakis, Spiros; Klaoudatou, Ifigeneia [American University of the Middle East, Department of Mathematics, P. O. Box 220, Dasman (Kuwait)

    2016-09-15

    We study spacetime singularities in a general five-dimensional braneworld with curved branes satisfying four-dimensional maximal symmetry. The bulk is supported by an analog of perfect fluid with the time replaced by the extra coordinate. We show that contrary to the existence of finite-distance singularities from the brane location in any solution with flat (Minkowski) branes, in the case of curved branes there are singularity-free solutions for a range of equations of state compatible with the null energy condition. (orig.)

  14. Variation of curve number with storm depth

    Science.gov (United States)

    Banasik, K.; Hejduk, L.

    2012-04-01

    The NRCS Curve Number (known also as SCS-CN) method is well known as a tool in predicting flood runoff depth from small ungauged catchment. The traditional way of determination the CNs, based on soil characteristics, land use and hydrological conditions, seemed to have tendency to overpredict the floods in some cases. Over 30 year rainfall-runoff data, collected in two small (A=23.4 & 82.4 km2), lowland, agricultural catchments in Center of Poland (Banasik & Woodward 2010), were used to determine runoff Curve Number and to check a tendency of changing. The observed CN declines with increasing storm size, which according recent views of Hawkins (1993) could be classified as a standard response of watershed. The analysis concluded, that using CN value according to the procedure described in USDA-SCS Handbook one receives representative value for estimating storm runoff from high rainfall depths in the analyzes catchments. This has been confirmed by applying "asymptotic approach" for estimating the watershed curve number from the rainfall-runoff data. Furthermore, the analysis indicated that CN, estimated from mean retention parameter S of recorded events with rainfall depth higher than initial abstraction, is also approaching the theoretical CN. The observed CN, ranging from 59.8 to 97.1 and from 52.3 to 95.5, in the smaller and the larger catchment respectively, declines with increasing storm size, which has been classified as a standard response of watershed. The investigation demonstrated also changeability of the CN during a year, with much lower values during the vegetation season. Banasik K. & D.E. Woodward (2010). "Empirical determination of curve number for a small agricultural watrshed in Poland". 2nd Joint Federal Interagency Conference, Las Vegas, NV, June 27 - July 1, 2010 (http://acwi.gov/sos/pubs/2ndJFIC/Contents/10E_Banasik_ 28_02_10. pdf). Hawkins R. H. (1993). "Asymptotic determination of curve numbers from data". Journal of Irrigation and Drainage

  15. Interpolation and Polynomial Curve Fitting

    Science.gov (United States)

    Yang, Yajun; Gordon, Sheldon P.

    2014-01-01

    Two points determine a line. Three noncollinear points determine a quadratic function. Four points that do not lie on a lower-degree polynomial curve determine a cubic function. In general, n + 1 points uniquely determine a polynomial of degree n, presuming that they do not fall onto a polynomial of lower degree. The process of finding such a…

  16. Principal Curves on Riemannian Manifolds.

    Science.gov (United States)

    Hauberg, Soren

    2016-09-01

    Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimizes a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend to imply that the methods only work well when the manifold is mostly flat within the support of the generating distribution. We argue that instead of generalizing linear Euclidean models, it is more fruitful to generalize non-linear Euclidean models. Specifically, we extend the classic Principal Curves from Hastie & Stuetzle to data residing on a complete Riemannian manifold. We show that for elliptical distributions in the tangent of spaces of constant curvature, the standard principal geodesic is a principal curve. The proposed model is simple to compute and avoids many of the pitfalls of traditional geodesic approaches. We empirically demonstrate the effectiveness of the Riemannian principal curves on several manifolds and datasets.

  17. Space curves, anholonomy and nonlinearity

    Indian Academy of Sciences (India)

    Radha Balakrishnan

    2005-04-01

    Using classical differential geometry, we discuss the phenomenon of anholonomy that gets associated with a static and a moving curve. We obtain the expressions for the respective geometric phases in the two cases and interpret them. We show that there is a close connection between anholonomy and nonlinearity in a wide class of nonlinear systems.

  18. The New Keynesian Phillips Curve

    DEFF Research Database (Denmark)

    Ólafsson, Tjörvi

    , learning or state-dependant pricing. The introduction of openeconomy factors into the new Keynesian Phillips curve complicate matters further as it must capture the nexus between price setting, inflation and the exchange rate. This is nevertheless a crucial feature for any model to be used for inflation...... forecasting in a small open economy like Iceland....

  19. S-shaped learning curves

    NARCIS (Netherlands)

    Murre, J.M.J.

    2014-01-01

    In this article, learning curves for foreign vocabulary words are investigated, distinguishing between a subject-specific learning rate and a material-specific parameter that is related to the complexity of the items, such as the number of syllables. Two experiments are described, one with Turkish w

  20. The soil reference shrinkage curve

    CERN Document Server

    Chertkov, V Y

    2014-01-01

    A recently proposed model showed how a clay shrinkage curve is transformed to the soil shrinkage curve at the soil clay content higher than a critical one. The objective of the present work was to generalize this model to the soil clay content lower a critical one. I investigated (i) the reference shrinkage curve, that is, one without cracks; (ii) the superficial layer of aggregates, with changed pore structure compared with the intraaggregate matrix; and (iii) soils with sufficiently low clay content where there are large pores inside the intraaggregate clay (so-called lacunar pores). The methodology is based on detail accounting for different contributions to the soil volume and water content during shrinkage. The key point is the calculation of the lacunar pore volume variance at shrinkage. The reference shrinkage curve is determined by eight physical soil parameters: (1) oven-dried specific volume; (2) maximum swelling water content; (3) mean solid density; (4) soil clay content; (5) oven-dried structural...

  1. Vibrational Analysis of Curved Single-Walled Carbon Nanotube on a Pasternak Elastic Foundation

    DEFF Research Database (Denmark)

    Mehdipour, I.; Barari, Amin; Kimiaeifar, Amin

    2012-01-01

    . By utilizing He’s Energy Balance Method (HEBM), the relationships of the nonlinear amplitude and frequency were expressed for a curved, single-walled carbon nanotube. The amplitude frequency response curves of the nonlinear free vibration were obtained for a curved, single-walled carbon nanotube embedded...

  2. Ramsay Curve IRT for Likert-Type Data

    Science.gov (United States)

    Woods, Carol M.

    2007-01-01

    Ramsay curve item response theory (RC-IRT) was recently developed to detect and correct for nonnormal latent variables when unidimensional IRT models are fitted to data using maximum marginal likelihood estimation. The purpose of this research is to evaluate the performance of RC-IRT for Likert-type item responses with varying test lengths, sample…

  3. The Grism Lens-amplified Survey from Space (GLASS). X. Sub-kiloparsec Resolution Gas-phase Metallicity Maps at Cosmic Noon behind the Hubble Frontier Fields Cluster MACS1149.6+2223

    Science.gov (United States)

    Wang, Xin; Jones, Tucker A.; Treu, Tommaso; Morishita, Takahiro; Abramson, Louis E.; Brammer, Gabriel B.; Huang, Kuang-Han; Malkan, Matthew A.; Schmidt, Kasper B.; Fontana, Adriano; Grillo, Claudio; Henry, Alaina L.; Karman, Wouter; Kelly, Patrick L.; Mason, Charlotte A.; Mercurio, Amata; Rosati, Piero; Sharon, Keren; Trenti, Michele; Vulcani, Benedetta

    2017-03-01

    We combine deep Hubble Space Telescope grism spectroscopy with a new Bayesian method to derive maps of gas-phase metallicity for 10 star-forming galaxies at high redshift (1.2≲ z≲ 2.3). Exploiting lensing magnification by the foreground cluster MACS1149.6+2223, we reach sub-kiloparsec spatial resolution and push the limit of stellar mass associated with such high-z spatially resolved measurements below {10}8 {M}ȯ for the first time. Our maps exhibit diverse morphologies, indicative of various effects such as efficient radial mixing from tidal torques, rapid accretion of low-metallicity gas, and other physical processes that can affect the gas and metallicity distributions in individual galaxies. Based upon an exhaustive sample of all existing sub-kiloparesec resolution metallicity gradient measurements at high z, we find that predictions given by analytical chemical evolution models assuming a relatively extended star-formation profile in the early disk-formation phase can explain the majority of observed metallicity gradients, without involving galactic feedback or radial outflows. We observe a tentative correlation between stellar mass and metallicity gradients, consistent with the “downsizing” galaxy formation picture that more massive galaxies are more evolved into a later phase of disk growth, where they experience more coherent mass assembly at all radii and thus show shallower metallicity gradients. In addition to the spatially resolved analysis, we compile a sample of homogeneously cross-calibrated integrated metallicity measurements spanning three orders of magnitude in stellar mass at z ∼ 1.8. We use this sample to study the mass–metallicity relation (MZR) and find that the slope of the observed MZR can rule out the momentum-driven wind model at a 3σ confidence level.

  4. Metallicities of Emission-Line Galaxies from HST ACS PEARS and HST WFC3 ERS Grism Spectroscopy at 0.6 is less than z is less than 2.4

    Science.gov (United States)

    Xia, Lifang; Malhotra, Sangetta; Rhoads, James; Pirzkal, Nor; Straughn, Amber; Finkelstein, Steven; Cohen, Seth; Kuntschner, Harald; Walsh, Jeremy; Windhorst, Rogier A.; O'Connell, Robert; Kuemmel, Martin

    2012-01-01

    Galaxies selected on the basis of their emission line strength. show low metallicities, regardless of their redshifts. We conclude this from a sample of faint galaxies at redshifts between 0.6 ACS) on the Hubble Space Telescope (HST) and in the near-infrared using Wide-Field Camera 3 (WFC3). Using a sample of 11 emission line galaxies (ELGs) at 0.6 < z < 2.4 with luminosities of -22 approx < MB approx -19 which have [OII], H-Beta, and [OIII] line flux measurements from the combination of two grism spectral surveys, we use the R23 method to derive the gas-phase oxygen abundances: 7.5 <12+log(0/H)<8.5. The galaxy stellar masses are derived using Bayesian based Markov Chain Monte Carlo (pi MC(exp 2)) fitting of their Spectral Energy Distribution (SED), and span the mass range 8.1 < log(M(stellar)/M(solar)) < 10.1. These galaxies show a mass-metal1icity (M-L) and Luminosity-Metallicity (LZ) relation, which is offset by -

  5. The Grism Lens-Amplified Survey from Space (GLASS). VI. Comparing the Mass and Light in MACS J0416.1-2403 Using Frontier Field Imaging and GLASS Spectroscopy

    Science.gov (United States)

    Hoag, A.; Huang, K.-H.; Treu, T.; Bradač, M.; Schmidt, K. B.; Wang, X.; Brammer, G. B.; Broussard, A.; Amorin, R.; Castellano, M.; Fontana, A.; Merlin, E.; Schrabback, T.; Trenti, M.; Vulcani, B.

    2016-11-01

    We present a model using both strong and weak gravitational lensing of the galaxy cluster MACS J0416.1-2403, constrained using spectroscopy from the Grism Lens-Amplified Survey from Space (GLASS) and Hubble Frontier Fields (HFF) imaging data. We search for emission lines in known multiply imaged sources in the GLASS spectra, obtaining secure spectroscopic redshifts of 30 multiple images belonging to 15 distinct source galaxies. The GLASS spectra provide the first spectroscopic measurements for five of the source galaxies. The weak lensing signal is acquired from 884 galaxies in the F606W HFF image. By combining the weak lensing constraints with 15 multiple image systems with spectroscopic redshifts and nine multiple image systems with photometric redshifts, we reconstruct the gravitational potential of the cluster on an adaptive grid. The resulting map of total mass density is compared with a map of stellar mass density obtained from the deep Spitzer Frontier Fields imaging data to study the relative distribution of stellar and total mass in the cluster. We find that the projected stellar mass to total mass ratio, f ⋆, varies considerably with the stellar surface mass density. The mean projected stellar mass to total mass ratio is =0.009+/- 0.003 (stat.), but with a systematic error as large as 0.004-0.005, dominated by the choice of the initial mass function. We find agreement with several recent measurements of f ⋆ in massive cluster environments. The lensing maps of convergence, shear, and magnification are made available to the broader community in the standard HFF format.

  6. A catalog of special plane curves

    CERN Document Server

    Lawrence, J Dennis

    2014-01-01

    Among the largest, finest collections available-illustrated not only once for each curve, but also for various values of any parameters present. Covers general properties of curves and types of derived curves. Curves illustrated by a CalComp digital incremental plotter. 12 illustrations.

  7. Principal Curves on Riemannian Manifolds

    DEFF Research Database (Denmark)

    Hauberg, Søren

    2015-01-01

    Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only...... in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimize a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend...... from Hastie & Stuetzle to data residing on a complete Riemannian manifold. We show that for elliptical distributions in the tangent of spaces of constant curvature, the standard principal geodesic is a principal curve. The proposed model is simple to compute and avoids many of the pitfalls...

  8. Invariance for Single Curved Manifold

    KAUST Repository

    Castro, Pedro Machado Manhaes de

    2012-08-01

    Recently, it has been shown that, for Lambert illumination model, solely scenes composed by developable objects with a very particular albedo distribution produce an (2D) image with isolines that are (almost) invariant to light direction change. In this work, we provide and investigate a more general framework, and we show that, in general, the requirement for such in variances is quite strong, and is related to the differential geometry of the objects. More precisely, it is proved that single curved manifolds, i.e., manifolds such that at each point there is at most one principal curvature direction, produce invariant is surfaces for a certain relevant family of energy functions. In the three-dimensional case, the associated energy function corresponds to the classical Lambert illumination model with albedo. This result is also extended for finite-dimensional scenes composed by single curved objects. © 2012 IEEE.

  9. Optical conductivity of curved graphene.

    Science.gov (United States)

    Chaves, A J; Frederico, T; Oliveira, O; de Paula, W; Santos, M C

    2014-05-07

    We compute the optical conductivity for an out-of-plane deformation in graphene using an approach based on solutions of the Dirac equation in curved space. Different examples of periodic deformations along one direction translates into an enhancement of the optical conductivity peaks in the region of the far- and mid-infrared frequencies for periodicities ∼100 nm. The width and position of the peaks can be changed by dialling the parameters of the deformation profiles. The enhancement of the optical conductivity is due to intraband transitions and the translational invariance breaking in the geometrically deformed background. Furthermore, we derive an analytical solution of the Dirac equation in a curved space for a general deformation along one spatial direction. For this class of geometries, it is shown that curvature induces an extra phase in the electron wave function, which can also be explored to produce interference devices of the Aharonov-Bohm type.

  10. Supersymmetric Spacetimes from Curved Superspace

    CERN Document Server

    Kuzenko, Sergei M

    2015-01-01

    We review the superspace technique to determine supersymmetric spacetimes in the framework of off-shell formulations for supergravity in diverse dimensions using the case of 3D N=2 supergravity theories as an illustrative example. This geometric formalism has several advantages over other approaches advocated in the last four years. Firstly, the infinitesimal isometry transformations of a given curved superspace form, by construction, a finite-dimensional Lie superalgebra, with its odd part corresponding to the rigid supersymmetry transformations. Secondly, the generalised Killing spinor equation, which must be obeyed by the supersymmetry parameters, is a consequence of the more fundamental superfield Killing equation. Thirdly, general rigid supersymmetric theories on a curved spacetime are readily constructed in superspace by making use of the known off-shell supergravity-matter couplings and restricting them to the background chosen. It is the superspace techniques which make it possible to generate arbitra...

  11. Curved canals: Ancestral files revisited

    Directory of Open Access Journals (Sweden)

    Jain Nidhi

    2008-01-01

    Full Text Available The aim of this article is to provide an insight into different techniques of cleaning and shaping of curved root canals with hand instruments. Although a plethora of root canal instruments like ProFile, ProTaper, LightSpeed ® etc dominate the current scenario, the inexpensive conventional root canal hand files such as K-files and flexible files can be used to get optimum results when handled meticulously. Special emphasis has been put on the modifications in biomechanical canal preparation in a variety of curved canal cases. This article compiles a series of clinical cases of root canals with curvatures in the middle and apical third and with S-shaped curvatures that were successfully completed by employing only conventional root canal hand instruments.

  12. A Study of Hyperelliptic Curves in Cryptography

    Directory of Open Access Journals (Sweden)

    Reza Alimoradi

    2016-08-01

    Full Text Available Elliptic curves are some specific type of curves known as hyper elliptic curves. Compared to the integer factorization problem(IFP based systems, using elliptic curve based cryptography will significantly decrease key size of the encryption. Therefore, application of this type of cryptography in systems that need high security and smaller key size has found great attention. Hyperelliptic curves help to make key length shorter. Many investigations are done with regard to improving computations, hardware and software implementation of these curves, their security and resistance against attacks. This paper studies and analyzes researches done about security and efficiency of hyperelliptic curves.

  13. Elastic Curves on the Sphere

    Science.gov (United States)

    1992-12-16

    12 = (K,, + )- (29) K 2 (see [3]). The parameter KM represents the amplitude of the periodic curva - ture function and sm denotes the value at which K...Additamentum De curvis elasticis. Methodus Inveniendi Lineas Curvas Maximi Minimive Proprietate Gaudentes, Ser. 1., Vol. 24, Lausanne 1744. 17 [10...Mathematical Theory of Elasticity. 4th. ed., Cambridge University Press, 1927. [12] G. Nielson. Bernstein/ Bezier Curves and Splines on Spheres based upon

  14. Accelerating Around an Unbanked Curve

    Science.gov (United States)

    Mungan, Carl E.

    2006-02-01

    The December 2004 issue of TPT presented a problem concerning how a car should accelerate around an unbanked curve of constant radius r starting from rest if it is to avoid skidding. Interestingly enough, two solutions were proffered by readers.2 The purpose of this note is to compare and contrast the two approaches. Further experimental investigation of various turning strategies using a remote-controlled car and overhead video analysis could make for an interesting student project.

  15. Macdonald formula for curves with planar singularities

    CERN Document Server

    Maulik, Davesh

    2011-01-01

    We generalize Macdonald's formula for the cohomology of Hilbert schemes of points on a curve from smooth curves to curves with planar singularities: we relate the cohomology of the Hilbert schemes to the cohomology of the compactified Jacobian of the curve. The new formula is a consequence of a stronger identity between certain perverse sheaves defined by a family of curves satisfying mild conditions, whose proof makes an essential use of Ng\\^o's support theorem for compactified Jacobians.

  16. Bragg Curve, Biological Bragg Curve and Biological Issues in Space Radiation Protection with Shielding

    Science.gov (United States)

    Honglu, Wu; Cucinotta, F.A.; Durante, M.; Lin, Z.; Rusek, A.

    2006-01-01

    The space environment consists of a varying field of radiation particles including high-energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-LET gamma or X-rays, the presence of shielding does not always reduce the radiation risks for energetic charged particle exposure. Since the dose delivered by the charged particle increases sharply as the particle approaches the end of its range, a position known as the Bragg peak, the Bragg curve does not necessarily represent the biological damage along the particle traversal since biological effects are influenced by the track structure of both primary and secondary particles. Therefore, the biological Bragg curve is dependent on the energy and the type of the primary particle, and may vary for different biological endpoints. To achieve a Bragg curve distribution, we exposed cells to energetic heavy ions with the beam geometry parallel to a monolayer of fibroblasts. Qualitative analyses of gamma-H2AX fluorescence, a known marker of DSBs, indicated increased clustering of DNA damage before the Bragg peak, enhanced homogenous distribution at the peak, and provided visual evidence of high linear energy transfer (LET) particle traversal of cells beyond the Bragg peak. A quantitative biological response curve generated for micronuclei (MN) induction across the Bragg curve did not reveal an increased yield of MN at the location of the Bragg peak. However, the ratio of mono-to bi-nucleated cells, which indicates inhibition in cell progression, increased at the Bragg peak location. These results, along with other biological concerns, show that space radiation protection with shielding can be a complicated issue.

  17. LINS Curve in Romanian Economy

    Directory of Open Access Journals (Sweden)

    Emilian Dobrescu

    2016-02-01

    Full Text Available The paper presents theoretical considerations and empirical evidence to test the validity of the Laffer in Narrower Sense (LINS curve as a parabola with a maximum. Attention is focused on the so-called legal-effective tax gap (letg. The econometric application is based on statistical data (1990-2013 for Romania as an emerging European economy. Three cointegrating regressions (fully modified least squares, canonical cointegrating regression and dynamic least squares and three algorithms, which are based on instrumental variables (two-stage least squares, generalized method of moments, and limited information maximum likelihood, are involved.

  18. Principal -bundles on Nodal Curves

    Indian Academy of Sciences (India)

    Usha N Bhosle

    2001-08-01

    Let be a connected semisimple affine algebraic group defined over . We study the relation between stable, semistable -bundles on a nodal curve and representations of the fundamental group of . This study is done by extending the notion of (generalized) parabolic vector bundles to principal -bundles on the desingularization of and using the correspondence between them and principal -bundles on . We give an isomorphism of the stack of generalized parabolic bundles on with a quotient stack associated to loop groups. We show that if is simple and simply connected then the Picard group of the stack of principal -bundles on is isomorphic to ⊕ , being the number of components of .

  19. Sound propagation over curved barriers

    Science.gov (United States)

    Pierce, Allan D.; Main, Geoffrey L.; Kearns, James A.; Hsieh, H.-A.

    1986-01-01

    Wide barriers with curved tops are studied with emphasis placed on circumstances whereby the local radius of curvature R of the barrier is continuous along the surface and is large compared to a wavelength. Results analogous to those given by Hayek et al. (1978) are reviewed and extended to cases where the radius of curvature and the surface impedance may vary with position. Circumstances not easily interpreted within the framework of the model proposed by Keller (1956) and Hayek et al. are also considered.

  20. Reconfigurable Double-Curved Mould

    DEFF Research Database (Denmark)

    Raun, Christian; Kirkegaard, Poul Henning

    2012-01-01

    . This happens fast, automatic and without production of waste, and the manipulated surface is fair and robust, eliminating the need for additional, manual treatment. Limitations to the possibilities of the flexible form are limited curvature and limited level of detail, making it especially suited for larger......, double curved surfaces like facades or walls, where the curvature of each element is relatively small in comparison to the overall shape. In the proposed dynamic mould system, where only a set of points is defined, a stiff membrane interpolates the surface between points. To function as a surface...

  1. Membranes Wrapped on Holomorphic Curves

    CERN Document Server

    Gauntlett, J P; Pakis, S; Waldram, D; Gauntlett, Jerome P.; Kim, Nakwoo; Pakis, Stathis; Waldram, Daniel

    2002-01-01

    We construct supergravity solutions dual to the twisted field theories arising when M-theory membranes wrap holomorphic curves in Calabi-Yau n-folds. The solutions are constructed in an Abelian truncation of maximal D=4 gauged supergravity and then uplifted to D=11. For four-folds and five-folds we find new smooth AdS/CFT examples and for all cases we analyse the nature of the singularities that arise. Our results provide an interpretation of certain charged topological AdS black holes. We also present the generalised calibration two-forms for the solutions.

  2. Accurate determination of characteristic relative permeability curves

    Science.gov (United States)

    Krause, Michael H.; Benson, Sally M.

    2015-09-01

    A recently developed technique to accurately characterize sub-core scale heterogeneity is applied to investigate the factors responsible for flowrate-dependent effective relative permeability curves measured on core samples in the laboratory. The dependency of laboratory measured relative permeability on flowrate has long been both supported and challenged by a number of investigators. Studies have shown that this apparent flowrate dependency is a result of both sub-core scale heterogeneity and outlet boundary effects. However this has only been demonstrated numerically for highly simplified models of porous media. In this paper, flowrate dependency of effective relative permeability is demonstrated using two rock cores, a Berea Sandstone and a heterogeneous sandstone from the Otway Basin Pilot Project in Australia. Numerical simulations of steady-state coreflooding experiments are conducted at a number of injection rates using a single set of input characteristic relative permeability curves. Effective relative permeability is then calculated from the simulation data using standard interpretation methods for calculating relative permeability from steady-state tests. Results show that simplified approaches may be used to determine flowrate-independent characteristic relative permeability provided flow rate is sufficiently high, and the core heterogeneity is relatively low. It is also shown that characteristic relative permeability can be determined at any typical flowrate, and even for geologically complex models, when using accurate three-dimensional models.

  3. Differential geometry and topology of curves

    CERN Document Server

    Animov, Yu

    2001-01-01

    Differential geometry is an actively developing area of modern mathematics. This volume presents a classical approach to the general topics of the geometry of curves, including the theory of curves in n-dimensional Euclidean space. The author investigates problems for special classes of curves and gives the working method used to obtain the conditions for closed polygonal curves. The proof of the Bakel-Werner theorem in conditions of boundedness for curves with periodic curvature and torsion is also presented. This volume also highlights the contributions made by great geometers. past and present, to differential geometry and the topology of curves.

  4. Smarandache Curves in Minkowski Space-time

    OpenAIRE

    Turgut, Melih; Yilmaz, Suha

    2008-01-01

    A regular curve in Minkowski space-time, whose position vector is composed by Frenet frame vectors on another regular curve, is called a Smarandache Curve. In this paper, we define a special case of such curves and call it Smarandache TB2 Curves in the space E41. Moreover, we compute formulas of its Frenet apparatus according to base curve via the method expressed in [3]. By this way, we obtain an another orthonormal frame of E41.

  5. Visualization of Growth Curve Data from Phenotype MicroarrayExperiments

    Energy Technology Data Exchange (ETDEWEB)

    Jacobsen, Janet S.; Joyner, Dominique C.; Borglin, Sharon E.; Hazen, Terry C.; Arkin, Adam P.; Bethel, E. Wes

    2007-04-19

    Phenotype microarrays provide a technology to simultaneouslysurvey the response of an organism to nearly 2,000 substrates, includingcarbon, nitrogen and potassium sources; varying pH; varying saltconcentrations; and antibiotics. In order to more quickly and easily viewand compare the large number of growth curves produced by phenotypemicroarray experiments, we have developed software to produce and displaycolor images, each of which corresponds to a set of 96 growth curves.Using color images to represent growth curves data has proven to be avaluable way to assess experiment quality, compare replicates, facilitatecomparison of the responses of different organisms, and identifysignificant phenotypes. The color images are linked to traditional plotsof growth versus time, as well as to information about the experiment,organism, and substrate. In order to share and view information and dataproject-wide, all information, plots, and data are accessible using onlya Web browser.

  6. Visualization of Growth Curve Data from Phenotype MicroarrayExperiments

    Energy Technology Data Exchange (ETDEWEB)

    Jacobsen, Janet S.; Joyner, Dominique C.; Borglin, Sharon E.; Hazen, Terry C.; Arkin, Adam P.; Bethel, E. Wes

    2007-04-19

    Phenotype microarrays provide a technology to simultaneouslysurvey the response of an organism to nearly 2,000 substrates, includingcarbon, nitrogen and potassium sources; varying pH; varying saltconcentrations; and antibiotics. In order to more quickly and easily viewand compare the large number of growth curves produced by phenotypemicroarray experiments, we have developed software to produce and displaycolor images, each of which corresponds to a set of 96 growth curves.Using color images to represent growth curves data has proven to be avaluable way to assess experiment quality, compare replicates, facilitatecomparison of the responses of different organisms, and identifysignificant phenotypes. The color images are linked to traditional plotsof growth versus time, as well as to information about the experiment,organism, and substrate. In order to share and view information and dataproject-wide, all information, plots, and data are accessible using onlya Web browser.

  7. Flow characteristics of curved ducts

    Directory of Open Access Journals (Sweden)

    Rudolf P.

    2007-10-01

    Full Text Available Curved channels are very often present in real hydraulic systems, e.g. curved diffusers of hydraulic turbines, S-shaped bulb turbines, fittings, etc. Curvature brings change of velocity profile, generation of vortices and production of hydraulic losses. Flow simulation using CFD techniques were performed to understand these phenomena. Cases ranging from single elbow to coupled elbows in shapes of U, S and spatial right angle position with circular cross-section were modeled for Re = 60000. Spatial development of the flow was studied and consequently it was deduced that minor losses are connected with the transformation of pressure energy into kinetic energy and vice versa. This transformation is a dissipative process and is reflected in the amount of the energy irreversibly lost. Least loss coefficient is connected with flow in U-shape elbows, biggest one with flow in Sshape elbows. Finally, the extent of the flow domain influenced by presence of curvature was examined. This isimportant for proper placement of mano- and flowmeters during experimental tests. Simulations were verified with experimental results presented in literature.

  8. Capacity theory on algebraic curves

    CERN Document Server

    Rumely, Robert S

    1989-01-01

    Capacity is a measure of size for sets, with diverse applications in potential theory, probability and number theory. This book lays foundations for a theory of capacity for adelic sets on algebraic curves. Its main result is an arithmetic one, a generalization of a theorem of Fekete and Szegö which gives a sharp existence/finiteness criterion for algebraic points whose conjugates lie near a specified set on a curve. The book brings out a deep connection between the classical Green's functions of analysis and Néron's local height pairings; it also points to an interpretation of capacity as a kind of intersection index in the framework of Arakelov Theory. It is a research monograph and will primarily be of interest to number theorists and algebraic geometers; because of applications of the theory, it may also be of interest to logicians. The theory presented generalizes one due to David Cantor for the projective line. As with most adelic theories, it has a local and a global part. Let /K be a smooth, complet...

  9. Miniature curved artificial compound eyes.

    Science.gov (United States)

    Floreano, Dario; Pericet-Camara, Ramon; Viollet, Stéphane; Ruffier, Franck; Brückner, Andreas; Leitel, Robert; Buss, Wolfgang; Menouni, Mohsine; Expert, Fabien; Juston, Raphaël; Dobrzynski, Michal Karol; L'Eplattenier, Geraud; Recktenwald, Fabian; Mallot, Hanspeter A; Franceschini, Nicolas

    2013-06-04

    In most animal species, vision is mediated by compound eyes, which offer lower resolution than vertebrate single-lens eyes, but significantly larger fields of view with negligible distortion and spherical aberration, as well as high temporal resolution in a tiny package. Compound eyes are ideally suited for fast panoramic motion perception. Engineering a miniature artificial compound eye is challenging because it requires accurate alignment of photoreceptive and optical components on a curved surface. Here, we describe a unique design method for biomimetic compound eyes featuring a panoramic, undistorted field of view in a very thin package. The design consists of three planar layers of separately produced arrays, namely, a microlens array, a neuromorphic photodetector array, and a flexible printed circuit board that are stacked, cut, and curved to produce a mechanically flexible imager. Following this method, we have prototyped and characterized an artificial compound eye bearing a hemispherical field of view with embedded and programmable low-power signal processing, high temporal resolution, and local adaptation to illumination. The prototyped artificial compound eye possesses several characteristics similar to the eye of the fruit fly Drosophila and other arthropod species. This design method opens up additional vistas for a broad range of applications in which wide field motion detection is at a premium, such as collision-free navigation of terrestrial and aerospace vehicles, and for the experimental testing of insect vision theories.

  10. Curve Length Estimation using Vertix Chain Code Curve Length Estimation

    Directory of Open Access Journals (Sweden)

    Habibollah Haron

    2010-09-01

    Full Text Available Most of the applications in image analysis are based on Freeman chain code. In this paper, for the first time, vertex chain code (VCC proposed by Bribiesca is applied to improve length estimation of the 2D digitized curve. The chain code has some preferences such as stable in shifting, turning, mirroring movement of image and has normalized starting point. Due to the variety of length estimator methods, we focused on the three specific techniques. First, the way Bribiesca proposed which is based on counting links between vertices; second, based on maximum length digital straight segments (DSSs and lastly local metrics. The results of these length estimators with the real perimeter are compared. Results thus obtained exhibits thatlength estimation using VCC is nearest to the actual length.

  11. Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging and DNA Repair Processes in Shaping the Dose-Response Curve of KBrO3-Induced DNA Damage

    Directory of Open Access Journals (Sweden)

    Maria A. Spassova

    2015-01-01

    Full Text Available We have developed a kinetic model to investigate how DNA repair processes and scavengers of reactive oxygen species (ROS can affect the dose-response shape of prooxidant induced DNA damage. We used as an example chemical KBrO3 which is activated by glutathione and forms reactive intermediates that directly interact with DNA to form 8-hydroxy-2-deoxyguanosine DNA adducts (8-OH-dG. The single strand breaks (SSB that can result from failed base excision repair of these adducts were considered as an effect downstream from 8-OH-dG. We previously demonstrated that, in the presence of effective base excision repair, 8-OH-dG can exhibit threshold-like dose-response dependence, while the downstream SSB can still exhibit a linear dose-response. Here we demonstrate that this result holds for a variety of conditions, including low levels of GSH, the presence of additional SSB repair mechanisms, or a scavenger. It has been shown that melatonin, a terminal scavenger, inhibits KBrO3-caused oxidative damage. Our modeling revealed that sustained exposure to KBrO3 can lead to fast scavenger exhaustion, in which case the dose-response shapes for both endpoints are not substantially affected. The results are important to consider when forming conclusions on a chemical’s toxicity dose dependence based on the dose-response of early genotoxic events.

  12. Leptogenesis from loop effects in curved spacetime

    CERN Document Server

    McDonald, Jamie I

    2015-01-01

    We describe a new mechanism -- radiatively-induced gravitational leptogenesis -- for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrat...

  13. Numerical computation of fragility curves for NPP equipment

    Energy Technology Data Exchange (ETDEWEB)

    Zentner, I., E-mail: irmela.zentner@edf.f [LaMSID, Laboratory for the Mechanics of Aging Industrial Structures, UMR EDF/CNRS, 1, av. du General de Gaulle, 92141 Clamart (France)

    2010-06-15

    The seismic probabilistic risk assessment (PRA) methodology is a popular approach for evaluating the risk of failure of engineering structures due to earthquake. In this framework, fragility curves express the conditional probability of failure of a structure or component for a given seismic input motion parameter A, such as peak ground acceleration (PGA) or spectral acceleration. The failure probability due to a seismic event is obtained by convolution of fragility curves with seismic hazard curves. In general, a log-normal model is used in order to estimate fragilities. In nuclear engineering practice, these fragilities are determined using safety factors with respect to design earthquake. This approach allows to determine fragility curves based on design study but largely draws on expert judgement and simplifying assumptions. When a more realistic assessment of seismic fragility is needed, simulation-based statistical estimation of fragility curves is more appropriate. In this paper, we will discuss statistical estimation of parameters of fragility curves and present results obtained for a reactor coolant system of nuclear power plant. We have performed non-linear dynamic response analyses using artificially generated strong motion time histories. Uncertainties due to seismic loads as well as model uncertainties are taken into account and propagated using Monte Carlo simulation.

  14. Fragility curves of concrete bridges retrofitted by column jacketing

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Northridge earthquake inflicted various levels of damage upon a large number of Caltrans' bridges not retrofitted by column jacketing. In this respect, this study represents results of fragility curve development for two (2) sample bridges typical in southern California, strengthened for seismic retrofit by means of steel jacketing of bridge columns. Monte Carlo simulation is performed to study nonlinear dynamic responses of the bridges before and after column retrofit. Fragility curves in this study are represented by Iognormal distribution functions with two parameters and developed as a function of PGA. The sixty (60) ground acceleration time histories for the Los Angeles area developed for the Federal Emergency Management Agcncy (FEMA) SAC (SEAOC-ATC-CUREe) steel project are used for the dynamic analysis of the bridges.The improvement in the fiagility with steel jacketing is quantified by comparing fragility curves of the bridge before and after column retrofit. In this first attempt to formulate the problem of fragility enhancement, the quantification is made by comparing the median values of the fragility curves before and after the retrofit. Under the hypothesis that this quantification also applies to empirical fragility curves developed on the basis of Northridge earthquake damage, the enhanced version of the empirical curves is developed for the ensuing analysis to determine the enhancement of transportation network performance due to the retrofit.

  15. Fragility curves of concrete bridges retrofitted by column jacketing

    Science.gov (United States)

    Shinozuka, Masanobu; Kim, Sang-Hoon; Kushiyama, Shigeru; Yi, Jin-Hak

    2002-12-01

    The Northridge earthquake inflicted various levels of damage upon a large number of Caltrans’ bridges not retrofitted by column jacketing. In this respect, this study represents results of fragility curve development for two (2) sample bridges typical in southern California, strengthened for seismic retrofit by means of steel jacketing of bridge columns. Monte Carlo simulation is performed to study nonlinear dynamic responses of the bridges before and after column retrofit. Fragility curves in this study are represented by lognormal distribution functions with two parameters and developed as a function of PGA. The sixty (60) ground acceleration time histories for the Los Angeles area developed for the Federal Emergency Management Agcncy (FEMA) SAC (SEAOC-ATC-CUREe) steel project are used for the dynamic analysis of the bridges. The improvement in the fragility with steel jacketing is quantified by comparing fragility curves of the bridge before and after column retrofit. In this first attempt to formulate the problem of fragility enhancement, the quantification is made by comparing the median values of the fragility curves before and after the retrofit. Under the hypothesis that this quantification also applies to empirical fragility curves developed on the basis of Northridge earthquake damage, the enhanced version of the empirical curves is developed for the ensuing analysis to determine the enhancement of transportation network performance due to the retrofit.

  16. Transition curves for highway geometric design

    CERN Document Server

    Kobryń, Andrzej

    2017-01-01

    This book provides concise descriptions of the various solutions of transition curves, which can be used in geometric design of roads and highways. It presents mathematical methods and curvature functions for defining transition curves. .

  17. Atlas of stress-strain curves

    CERN Document Server

    2002-01-01

    The Atlas of Stress-Strain Curves, Second Edition is substantially bigger in page dimensions, number of pages, and total number of curves than the previous edition. It contains over 1,400 curves, almost three times as many as in the 1987 edition. The curves are normalized in appearance to aid making comparisons among materials. All diagrams include metric (SI) units, and many also include U.S. customary units. All curves are captioned in a consistent format with valuable information including (as available) standard designation, the primary source of the curve, mechanical properties (including hardening exponent and strength coefficient), condition of sample, strain rate, test temperature, and alloy composition. Curve types include monotonic and cyclic stress-strain, isochronous stress-strain, and tangent modulus. Curves are logically arranged and indexed for fast retrieval of information. The book also includes an introduction that provides background information on methods of stress-strain determination, on...

  18. Curved Gabor Filters for Fingerprint Image Enhancement

    CERN Document Server

    Gottschlich, Carsten

    2011-01-01

    Gabor filters play an important role in many application areas for the enhancement of various types of images and the extraction of Gabor features. For the purpose of enhancing curved structures in noisy images, we introduce curved Gabor filters which locally adapt their shape to the direction of flow. These curved Gabor filters enable the choice of filter parameters which increase the smoothing power without creating artifacts in the enhanced image. In this paper, curved Gabor filters are applied to the curved ridge and valley structure of low-quality fingerprint images. First, we combine two orientation field estimation methods in order to obtain a more robust estimation for very noisy images. Next, curved regions are constructed by following the respective local orientation and they are used for estimating the local ridge frequency. Lastly, curved Gabor filters are defined based on curved regions and they are applied for the enhancement of low-quality fingerprint images. Experimental results on the FVC2004...

  19. Whitney's formulas for curves on surfaces

    CERN Document Server

    Burman, Yurii

    2009-01-01

    The classical Whitney formula relates the number of times an oriented plane curve cuts itself to its rotation number and the index of a base point. In this paper we generalize Whitney's formula to curves on an oriented punctured surface. To define analogs of the rotation number and the index of a base point of a curve, we fix an arbitrary vector field on the surface. Similar formulas are obtained for non-based curves.

  20. Gelfond–Bézier curves

    KAUST Repository

    Ait-Haddou, Rachid

    2013-02-01

    We show that the generalized Bernstein bases in Müntz spaces defined by Hirschman and Widder (1949) and extended by Gelfond (1950) can be obtained as pointwise limits of the Chebyshev–Bernstein bases in Müntz spaces with respect to an interval [a,1][a,1] as the positive real number a converges to zero. Such a realization allows for concepts of curve design such as de Casteljau algorithm, blossom, dimension elevation to be transferred from the general theory of Chebyshev blossoms in Müntz spaces to these generalized Bernstein bases that we termed here as Gelfond–Bernstein bases. The advantage of working with Gelfond–Bernstein bases lies in the simplicity of the obtained concepts and algorithms as compared to their Chebyshev–Bernstein bases counterparts.

  1. Bacterial streamers in curved microchannels

    Science.gov (United States)

    Rusconi, Roberto; Lecuyer, Sigolene; Guglielmini, Laura; Stone, Howard

    2009-11-01

    Biofilms, generally identified as microbial communities embedded in a self-produced matrix of extracellular polymeric substances, are involved in a wide variety of health-related problems ranging from implant-associated infections to disease transmissions and dental plaque. The usual picture of these bacterial films is that they grow and develop on surfaces. However, suspended biofilm structures, or streamers, have been found in natural environments (e.g., rivers, acid mines, hydrothermal hot springs) and are always suggested to stem from a turbulent flow. We report the formation of bacterial streamers in curved microfluidic channels. By using confocal laser microscopy we are able to directly image and characterize the spatial and temporal evolution of these filamentous structures. Such streamers, which always connect the inner corners of opposite sides of the channel, are always located in the middle plane. Numerical simulations of the flow provide evidences for an underlying hydrodynamic mechanism behind the formation of the streamers.

  2. Counting rational points on cubic curves

    Institute of Scientific and Technical Information of China (English)

    HEATH-BROWN; Roger; TESTA; Damiano

    2010-01-01

    We prove upper bounds for the number of rational points on non-singular cubic curves defined over the rationals.The bounds are uniform in the curve and involve the rank of the corresponding Jacobian.The method used in the proof is a combination of the "determinant method" with an m-descent on the curve.

  3. Optimal investment in learning-curve technologies

    NARCIS (Netherlands)

    Della Seta, M.; Gryglewicz, S.; Kort, P.M.

    2012-01-01

    We study optimal investment in technologies characterized by the learning curve. There are two investment patterns depending on the shape of the learning curve. If the learning process is slow, firms invest relatively late and on a larger scale. If the curve is steep, firms invest earlier and on a s

  4. A STUDY ON JIG DISTRIBUTION CURVE TRANSFORMATION

    Institute of Scientific and Technical Information of China (English)

    路迈西; 常大山; 郭珍旭

    1991-01-01

    An investigation of the errors resulted from distribution curve transformations using six different methods was made on the basis of 61 sets of jig performance test data from the coal preparation plants in China. The results indicate that minimum error occurred when distribution curves were transformed by keeping imperfection I constant. Generalized distribution curves are developed for jigs and their applications are discussed.

  5. The Bezout Number of Piecewise Algebraic Curves

    Institute of Scientific and Technical Information of China (English)

    Dian Xuan GONG; Ren Hong WANG

    2012-01-01

    Based on the discussion of the number of roots of univariate spline and the common zero points of two piecewise algebraic curves,a lower upbound of Bezout number of two piecewise algebraic curves on any given non-obtuse-angled triangulation is found.Bezout number of two piecewise algebraic curves on two different partitions is also discussed in this paper.

  6. Automated Blazar Light Curves Using Machine Learning

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Spencer James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-27

    This presentation describes a problem and methodology pertaining to automated blazar light curves. Namely, optical variability patterns for blazars require the construction of light curves and in order to generate the light curves, data must be filtered before processing to ensure quality.

  7. AKLSQF - LEAST SQUARES CURVE FITTING

    Science.gov (United States)

    Kantak, A. V.

    1994-01-01

    The Least Squares Curve Fitting program, AKLSQF, computes the polynomial which will least square fit uniformly spaced data easily and efficiently. The program allows the user to specify the tolerable least squares error in the fitting or allows the user to specify the polynomial degree. In both cases AKLSQF returns the polynomial and the actual least squares fit error incurred in the operation. The data may be supplied to the routine either by direct keyboard entry or via a file. AKLSQF produces the least squares polynomial in two steps. First, the data points are least squares fitted using the orthogonal factorial polynomials. The result is then reduced to a regular polynomial using Sterling numbers of the first kind. If an error tolerance is specified, the program starts with a polynomial of degree 1 and computes the least squares fit error. The degree of the polynomial used for fitting is then increased successively until the error criterion specified by the user is met. At every step the polynomial as well as the least squares fitting error is printed to the screen. In general, the program can produce a curve fitting up to a 100 degree polynomial. All computations in the program are carried out under Double Precision format for real numbers and under long integer format for integers to provide the maximum accuracy possible. AKLSQF was written for an IBM PC X/AT or compatible using Microsoft's Quick Basic compiler. It has been implemented under DOS 3.2.1 using 23K of RAM. AKLSQF was developed in 1989.

  8. Caloric curve of star clusters.

    Science.gov (United States)

    Casetti, Lapo; Nardini, Cesare

    2012-06-01

    Self-gravitating systems, such as globular clusters or elliptical galaxies, are the prototypes of many-body systems with long-range interactions, and should be the natural arena in which to test theoretical predictions on the statistical behavior of long-range-interacting systems. Systems of classical self-gravitating particles can be studied with the standard tools of equilibrium statistical mechanics, provided the potential is regularized at small length scales and the system is confined in a box. The confinement condition looks rather unphysical in general, so that it is natural to ask whether what we learn with these studies is relevant to real self-gravitating systems. In order to provide an answer to this question, we consider a basic, simple, yet effective model of globular clusters: the King model. This model describes a self-consistently confined system, without the need of any external box, but the stationary state is a nonthermal one. In particular, we consider the King model with a short-distance cutoff on the interactions, and we discuss how such a cutoff affects the caloric curve, i.e., the relation between temperature and energy. We find that the cutoff stabilizes a low-energy phase, which is absent in the King model without cutoff; the caloric curve of the model with cutoff turns out to be very similar to that of previously studied confined and regularized models, but for the absence of a high-energy gaslike phase. We briefly discuss the possible phenomenological as well as theoretical implications of these results.

  9. Method of construction spatial transition curve

    Directory of Open Access Journals (Sweden)

    S.V. Didanov

    2013-04-01

    Full Text Available Purpose. The movement of rail transport (speed rolling stock, traffic safety, etc. is largely dependent on the quality of the track. In this case, a special role is the transition curve, which ensures smooth insertion of the transition from linear to circular section of road. The article deals with modeling of spatial transition curve based on the parabolic distribution of the curvature and torsion. This is a continuation of research conducted by the authors regarding the spatial modeling of curved contours. Methodology. Construction of the spatial transition curve is numerical methods for solving nonlinear integral equations, where the initial data are taken coordinate the starting and ending points of the curve of the future, and the inclination of the tangent and the deviation of the curve from the tangent plane at these points. System solutions for the numerical method are the partial derivatives of the equations of the unknown parameters of the law of change of torsion and length of the transition curve. Findings. The parametric equations of the spatial transition curve are calculated by finding the unknown coefficients of the parabolic distribution of the curvature and torsion, as well as the spatial length of the transition curve. Originality. A method for constructing the spatial transition curve is devised, and based on this software geometric modeling spatial transition curves of railway track with specified deviations of the curve from the tangent plane. Practical value. The resulting curve can be applied in any sector of the economy, where it is necessary to ensure a smooth transition from linear to circular section of the curved space bypass. An example is the transition curve in the construction of the railway line, road, pipe, profile, flat section of the working blades of the turbine and compressor, the ship, plane, car, etc.

  10. Cubic Curves, Finite Geometry and Cryptography

    CERN Document Server

    Bruen, A A; Wehlau, D L

    2011-01-01

    Some geometry on non-singular cubic curves, mainly over finite fields, is surveyed. Such a curve has 9,3,1 or 0 points of inflexion, and cubic curves are classified accordingly. The group structure and the possible numbers of rational points are also surveyed. A possible strengthening of the security of elliptic curve cryptography is proposed using a `shared secret' related to the group law. Cubic curves are also used in a new way to construct sets of points having various combinatorial and geometric properties that are of particular interest in finite Desarguesian planes.

  11. On Self-growing Modeling for Curves

    Institute of Scientific and Technical Information of China (English)

    HUANG Dong-zhao; ZHU Zhi-hong; ZHOU Hui-cheng; SHI Han-min

    2008-01-01

    This paperpresents a novel curoe modeling method based on controlling rules of the shaping technique.The method describes the curve based on steplength and turning angle,and the characteristics of the curve near a point.Then it introduces the process to extract" growing-rules"for 2D and 3D curves described by familiar analytical expressions and curvature-torsion expressions.Examples of selfgrowing modeling for familiar analytical curves are presented.New curves are obtained by designing the grow-rules;corresponding examples are also presented.

  12. Koch Curves: Rewriting System, Geometry and Application

    Directory of Open Access Journals (Sweden)

    Mamta Rani

    2011-01-01

    Full Text Available Problem statement: Recently, new Koch curves have been generated by dividing the initiator into three unequal parts. There is no formal rewriting system to generate such kind of curves. Approach: It is required to measure the new changed geometrical properties. Generalized rewriting systems for the new Koch curves have been developed. Results: New formulas have been given to measure their geometrical properties. Conclusion/Recommendations: The geometrical properties of new Koch curves make them more suitable as antennas in wireless communication than the conventional Koch curve.

  13. Is the tautochrone curve unique?

    CERN Document Server

    Terra, Pedro; Farina, C

    2016-01-01

    The answer to this question is no. In fact, in addition to the solution first obtained by Christiaan Huygens in 1658, given by the cycloid, we show that there is an infinite number of tautochrone curves. With this goal, we start by briefly reviewing an the problem of finding out the possible potential energies that lead to periodic motions of a particle whose period is a given function of its mechanical energy. There are infinitely many solutions, called sheared potentials. As an interesting example, we show that a P\\"oschl-Teller and the one-dimensional Morse potentials are sheared relative to one another for negative energies, clarifying why they share the same periods of oscillations for their bounded solutions. We then consider periodic motions of a particle sliding without friction over a track around its minimum under the influence of an uniform gravitational field. After a brief historical survey of the tautochrone problem we show that, given the period of oscillations, there is an infinity of tracks w...

  14. Is the tautochrone curve unique?

    Science.gov (United States)

    Terra, Pedro; de Melo e Souza, Reinaldo; Farina, C.

    2016-12-01

    We show that there are an infinite number of tautochrone curves in addition to the cycloid solution first obtained by Christiaan Huygens in 1658. We begin by reviewing the inverse problem of finding the possible potential energy functions that lead to periodic motions of a particle whose period is a given function of its mechanical energy. There are infinitely many such solutions, called "sheared" potentials. As an interesting example, we show that a Pöschl-Teller potential and the one-dimensional Morse potentials are sheared relative to one another for negative energies, clarifying why they share the same oscillation periods for their bounded solutions. We then consider periodic motions of a particle sliding without friction over a track around its minimum under the influence of a constant gravitational field. After a brief historical survey of the tautochrone problem we show that, given the oscillation period, there is an infinity of tracks that lead to the same period. As a bonus, we show that there are infinitely many tautochrones.

  15. Algebraic points on meromorphic curves

    CERN Document Server

    Herblot, Mathilde

    2012-01-01

    The classic Schneider-Lang theorem in transcendence theory asserts that there are only finitely many points at which algebraically independent complex meromorphic functions of finite order of growth can simultaneously take values in a number field, when satisfying a polynomial differential equation with coefficients in this given number field. In this article, we are interested in generalizing this theorem in two directions. First, instead of considering meromorphic functions on C we consider holomorphic maps on an affine curve over the field C or C_p. This extends a statement of D. Bertrand, which applies to meromorphic functions on P^1(C) or P^1(C_p) minus a finite subset of points. Secondly, we deal with algebraic values taken by the functions, instead of rational values as in the classic setting, inspired by a work of D. Bertrand. We prove a geometric statement extending those two results, using the slopes method, written in the language of Arakelov geometry. In the complex case, we recover a special case...

  16. Quantum fields in curved spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Hollands, Stefan, E-mail: stefan.hollands@uni-leipzig.de [Universität Leipzig, Institut für Theoretische Physik, Brüderstrasse 16, D-04103 Leipzig (Germany); Wald, Robert M., E-mail: rmwa@uchicago.edu [Enrico Fermi Institute and Department of Physics, University of Chicago, Chicago, IL 60637 (United States)

    2015-04-16

    We review the theory of quantum fields propagating in an arbitrary, classical, globally hyperbolic spacetime. Our review emphasizes the conceptual issues arising in the formulation of the theory and presents known results in a mathematically precise way. Particular attention is paid to the distributional nature of quantum fields, to their local and covariant character, and to microlocal spectrum conditions satisfied by physically reasonable states. We review the Unruh and Hawking effects for free fields, as well as the behavior of free fields in deSitter spacetime and FLRW spacetimes with an exponential phase of expansion. We review how nonlinear observables of a free field, such as the stress–energy tensor, are defined, as well as time-ordered-products. The “renormalization ambiguities” involved in the definition of time-ordered products are fully characterized. Interacting fields are then perturbatively constructed. Our main focus is on the theory of a scalar field, but a brief discussion of gauge fields is included. We conclude with a brief discussion of a possible approach towards a nonperturbative formulation of quantum field theory in curved spacetime and some remarks on the formulation of quantum gravity.

  17. Simulations of Closed Timelike Curves

    Science.gov (United States)

    Brun, Todd A.; Wilde, Mark M.

    2017-03-01

    Proposed models of closed timelike curves (CTCs) have been shown to enable powerful information-processing protocols. We examine the simulation of models of CTCs both by other models of CTCs and by physical systems without access to CTCs. We prove that the recently proposed transition probability CTCs (T-CTCs) are physically equivalent to postselection CTCs (P-CTCs), in the sense that one model can simulate the other with reasonable overhead. As a consequence, their information-processing capabilities are equivalent. We also describe a method for quantum computers to simulate Deutschian CTCs (but with a reasonable overhead only in some cases). In cases for which the overhead is reasonable, it might be possible to perform the simulation in a table-top experiment. This approach has the benefit of resolving some ambiguities associated with the equivalent circuit model of Ralph et al. Furthermore, we provide an explicit form for the state of the CTC system such that it is a maximum-entropy state, as prescribed by Deutsch.

  18. The Influence of Human Interindividual Variability on the Low-Dose Region of Dose-Response Curve Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Primary B Cells.

    Science.gov (United States)

    Dornbos, Peter; Crawford, Robert B; Kaminski, Norbert E; Hession, Sarah L; LaPres, John J

    2016-10-01

    The influence of interindividual variability is not typically assessed in traditional toxicological studies. Given that chemical exposures occur in heterogeneous populations, this knowledge gap has the potential to cause undue harm within the realms of public health and industrial and municipal finances. A recent report from the National Research Council (NRC) suggests that when accounting for interindividual variation in responses, traditionally assumed nonlinear dose-response relationships (DRRs) for noncancer-causing endpoints would better be explained with a linear relationship within the low-dose region. To address this knowledge gap and directly test the NRC's assumption, this study focused on assessing the DRR between 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) exposure and immune suppression in a cohort of unique human donors. Human B cells were isolated from 51 individual donors and treated with logarithmically increasing concentrations of TCDD (0-30 nM TCDD). Two endpoints sensitive to TCDD were assessed: (1) number of IgM-secreting B cells and (2) quantity of IgM secreted. The results show that TCDD significantly suppressed both the number of IgM-secreting B cells and the quantity of IgM secreted (P < .05). Statistical model comparisons indicate that the low-dose region of the two DRRs is best explained with a nonlinear relationship. Rather than assuming low-dose linearity for all noncancer-causing DRRs, our study suggests the need to consider the specific mode of action of toxicants and pharmaceuticals during risk-management decision making. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Optimal vibration control of curved beams using distributed parameter models

    Science.gov (United States)

    Liu, Fushou; Jin, Dongping; Wen, Hao

    2016-12-01

    The design of linear quadratic optimal controller using spectral factorization method is studied for vibration suppression of curved beam structures modeled as distributed parameter models. The equations of motion for active control of the in-plane vibration of a curved beam are developed firstly considering its shear deformation and rotary inertia, and then the state space model of the curved beam is established directly using the partial differential equations of motion. The functional gains for the distributed parameter model of curved beam are calculated by extending the spectral factorization method. Moreover, the response of the closed-loop control system is derived explicitly in frequency domain. Finally, the suppression of the vibration at the free end of a cantilevered curved beam by point control moment is studied through numerical case studies, in which the benefit of the presented method is shown by comparison with a constant gain velocity feedback control law, and the performance of the presented method on avoidance of control spillover is demonstrated.

  20. Certified Approximation of Parametric Space Curves with Cubic B-spline Curves

    CERN Document Server

    Shen, Liyong; Gao, Xiao-Shan

    2012-01-01

    Approximating complex curves with simple parametric curves is widely used in CAGD, CG, and CNC. This paper presents an algorithm to compute a certified approximation to a given parametric space curve with cubic B-spline curves. By certified, we mean that the approximation can approximate the given curve to any given precision and preserve the geometric features of the given curve such as the topology, singular points, etc. The approximated curve is divided into segments called quasi-cubic B\\'{e}zier curve segments which have properties similar to a cubic rational B\\'{e}zier curve. And the approximate curve is naturally constructed as the associated cubic rational B\\'{e}zier curve of the control tetrahedron of a quasi-cubic curve. A novel optimization method is proposed to select proper weights in the cubic rational B\\'{e}zier curve to approximate the given curve. The error of the approximation is controlled by the size of its tetrahedron, which converges to zero by subdividing the curve segments. As an applic...

  1. Uniform trigonometric polynomial B-spline curves

    Institute of Scientific and Technical Information of China (English)

    吕勇刚; 汪国昭; 杨勋年

    2002-01-01

    This paper presents a new kind of uniform spline curve, named trigonometric polynomialB-splines, over space Ω = span{sint, cost, tk-3,tk-4,…,t,1} of which k is an arbitrary integerlarger than or equal to 3. We show that trigonometric polynomial B-spline curves have many similarV properties to traditional B-splines. Based on the explicit representation of the curve we have also presented the subdivision formulae for this new kind of curve. Since the new spline can include both polynomial curves and trigonometric curves as special cases without rational form, it can be used as an efficient new model for geometric design in the fields of CAD/CAM.

  2. Research on physical shape preserving curve reconstruction

    Institute of Scientific and Technical Information of China (English)

    TANG Kelun; ZHANG Xiangwei; CHENG Siyuan; XIONG Hanwei; ZHANG Hong

    2007-01-01

    Fusion of various data is an effective way to improve the precision and efficiency of acquiring information in reverse engineering.A method of physical shape preserving curve reconstruction is proposed to better realize the data fusion of coordinate measuring machine (CMM) and visual information.From the principle of materials mechanics,the strain energy of the curve corresponding to the distortion is advanced as the internal energy,and the elastic potential energy of the curve is established,using a few precise measured data points as the equilibrium position,to be the external energy.On the basis of the principle of variation calculus,the basic spline finite element method (B-spline FEM) is used to determine the equilibrium position of curve deformation.Numerical simulation indicates that there is an extremely good agreement between the new fitted curve and the actual curve.

  3. Forces in the complex octonion curved space

    CERN Document Server

    Weng, Zi-Hua

    2016-01-01

    The paper aims to extend major equations in the electromagnetic and gravitational theories from the flat space into the complex octonion curved space. Maxwell applied simultaneously the quaternion analysis and vector terminology to describe the electromagnetic theory. It inspires subsequent scholars to study the electromagnetic and gravitational theories with the complex quaternions/octonions. Furthermore Einstein was the first to depict the gravitational theory by means of tensor analysis and curved four-space-time. Nowadays some scholars investigate the electromagnetic and gravitational properties making use of the complex quaternion/octonion curved space. From the orthogonality of two complex quaternions, it is possible to define the covariant derivative of the complex quaternion curved space, describing the gravitational properties in the complex quaternion curved space. Further it is possible to define the covariant derivative of the complex octonion curved space by means of the orthogonality of two comp...

  4. Association between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests.

    Science.gov (United States)

    He, Zihuai; Payne, Erin K; Mukherjee, Bhramar; Lee, Seunggeun; Smith, Jennifer A; Ware, Erin B; Sánchez, Brisa N; Seeman, Teresa E; Kardia, Sharon L R; Diez Roux, Ana V

    2015-01-01

    The hormone cortisol is likely to be a key mediator of the stress response that influences multiple physiologic systems that are involved in common chronic disease, including the cardiovascular system, the immune system, and metabolism. In this paper, a candidate gene approach was used to investigate genetic contributions to variability in multiple correlated features of the daily cortisol profile in a sample of European Americans, African Americans, and Hispanic Americans from the Multi-Ethnic Study of Atherosclerosis (MESA). We proposed and applied a new gene-level multiple-phenotype analysis and carried out a meta-analysis to combine the ethnicity specific results. This new analysis, instead of a more routine single marker-single phenotype approach identified a significant association between one gene (ADRB2) and cortisol features (meta-analysis p-value=0.0025), which was not identified by three other commonly used existing analytic strategies: 1. Single marker association tests involving each single cortisol feature separately; 2. Single marker association tests jointly testing for multiple cortisol features; 3. Gene-level association tests separately carried out for each single cortisol feature. The analytic strategies presented consider different hypotheses regarding genotype-phenotype association and imply different costs of multiple testing. The proposed gene-level analysis integrating multiple cortisol features across multiple ethnic groups provides new insights into the gene-cortisol association.

  5. Conditionally bounding analytic ranks of elliptic curves

    CERN Document Server

    Bober, Jonathan W

    2011-01-01

    We describe a method for bounding the rank of an elliptic curve under the assumptions of the Birch and Swinnerton-Dyer conjecture and the generalized Riemann hypothesis. As an example, we compute, under these conjectures, exact upper bounds for curves which are known to have rank at least as large as 20, 21, 22, 23, and 24. For the known curve of rank at least 28, we get a bound of 30.

  6. Riemann Boundary Value Problems for Koch Curve

    Directory of Open Access Journals (Sweden)

    Zhengshun Ruanand

    2012-11-01

    Full Text Available In this study, when L is substituted for Koch curve, Riemann boundary value problems was defined, but generally speaking, Cauchy-type integral is meaningless on Koch curve. When some analytic conditions are attached to functions G (z and g (z, through the limit function of a sequence of Cauchytype integrals, the homogeneous and non-homogeneous Riemann boundary problems on Koch curve are introduced, some similar results was attained like the classical boundary value problems for analytic functions.

  7. Skill Acquisition Curves and Military Training

    Science.gov (United States)

    1986-01-01

    group acquisition curves had one of two general shapes, either logarithmic (power function) or semi- logarithmic (exponential), including variants...is, so far as we aware, no inherent advantage to the use of equations in linear or logarithmic form other than that the display of fitted curves in...implications for the expected form of the acquisition curve . As Mazur and Hastie (1978) note, accumulation models yield the hyperbola (a power law

  8. A Local Torelli's Theorem for SUSY curves

    CERN Document Server

    Codogni, Giulio

    2014-01-01

    SUSY curves, or super Riemann surfaces, are the generalization of Riemann surfaces in the context of super geometry. The main goal of this paper is to construct some explicit families of SUSY curves with odd moduli and compute their periods. By comparing our result with its classical analogue, we make an educated guess about the tangent space to the period domain and the differential of the Jacobian morphism for SUSY curves.

  9. Algebraic curves and one-dimensional fields

    CERN Document Server

    Bogomolov, Fedor

    2002-01-01

    Algebraic curves have many special properties that make their study particularly rewarding. As a result, curves provide a natural introduction to algebraic geometry. In this book, the authors also bring out aspects of curves that are unique to them and emphasize connections with algebra. This text covers the essential topics in the geometry of algebraic curves, such as line and vector bundles, the Riemann-Roch Theorem, divisors, coherent sheaves, and zeroth and first cohomology groups. The authors make a point of using concrete examples and explicit methods to ensure that the style is clear an

  10. Orthogonal Polynomials and $S$-curves

    CERN Document Server

    Rakhmanov, E A

    2011-01-01

    This paper is devoted to a study of $S$-curves, that is systems of curves in the complex plane whose equilibrium potential in a harmonic external field satisfies a special symmetry property ($S$-property). Such curves have many applications. In particular, they play a fundamental role in the theory of complex (non-hermitian) orthogonal polynomials. One of the main theorems on zero distribution of such polynomials asserts that the limit zero distribution is presented by an equilibrium measure of an $S$-curve associated with the problem if such a curve exists. These curves are also the starting point of the matrix Riemann-Hilbert approach to srtong asymptotics. Other approaches to the problem of strong asymptotics (differential equations, Riemann surfaces) are also related to $S$-curves or may be interpreted this way. Existence problem $S$-curve in a given class of curves in presence of a nontrivial external field presents certain challenge. We formulate and prove a version of existence theorem for the case whe...

  11. Therapy operating characteristic curves: tools for precision chemotherapy.

    Science.gov (United States)

    Barrett, Harrison H; Alberts, David S; Woolfenden, James M; Caucci, Luca; Hoppin, John W

    2016-04-01

    The therapy operating characteristic (TOC) curve, developed in the context of radiation therapy, is a plot of the probability of tumor control versus the probability of normal-tissue complications as the overall radiation dose level is varied, e.g., by varying the beam current in external-beam radiotherapy or the total injected activity in radionuclide therapy. This paper shows how TOC can be applied to chemotherapy with the administered drug dosage as the variable. The area under a TOC curve (AUTOC) can be used as a figure of merit for therapeutic efficacy, analogous to the area under an ROC curve (AUROC), which is a figure of merit for diagnostic efficacy. In radiation therapy, AUTOC can be computed for a single patient by using image data along with radiobiological models for tumor response and adverse side effects. The mathematical analogy between response of observers to images and the response of tumors to distributions of a chemotherapy drug is exploited to obtain linear discriminant functions from which AUTOC can be calculated. Methods for using mathematical models of drug delivery and tumor response with imaging data to estimate patient-specific parameters that are needed for calculation of AUTOC are outlined. The implications of this viewpoint for clinical trials are discussed.

  12. Modeling Pacing Behavior and Test Speededness Using Latent Growth Curve Models

    Science.gov (United States)

    Kahraman, Nilufer; Cuddy, Monica M.; Clauser, Brian E.

    2013-01-01

    This research explores the usefulness of latent growth curve modeling in the study of pacing behavior and test speededness. Examinee response times from a high-stakes, computerized examination, collected before and after the examination was subjected to a timing change, were analyzed using a series of latent growth curve models to detect…

  13. Leptogenesis from loop effects in curved spacetime

    Science.gov (United States)

    McDonald, Jamie I.; Shore, Graham M.

    2016-04-01

    We describe a new mechanism — radiatively-induced gravitational leptogenesis — for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrate by explicit computation of the relevant two-loop Feynman diagrams how the size of the radiative corrections relevant for leptogenesis becomes enhanced by increasing the mass hierarchy of the sterile neutrinos, and show how the induced lepton asymmetry may be sufficiently large to play an important rôle in determining the baryon-to-photon ratio of the Universe.

  14. Leptogenesis from loop effects in curved spacetime

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, Jamie I.; Shore, Graham M. [Department of Physics, Swansea University,Singleton Park, Swansea, SA2 8PP (United Kingdom)

    2016-04-05

    We describe a new mechanism — radiatively-induced gravitational leptogenesis — for generating the matter-antimatter asymmetry of the Universe. We show how quantum loop effects in C and CP violating theories cause matter and antimatter to propagate differently in the presence of gravity, and prove this is forbidden in flat space by CPT and translation symmetry. This generates a curvature-dependent chemical potential for leptons, allowing a matter-antimatter asymmetry to be generated in thermal equilibrium in the early Universe. The time-dependent dynamics necessary for leptogenesis is provided by the interaction of the virtual self-energy cloud of the leptons with the expanding curved spacetime background, which violates the strong equivalence principle and allows a distinction between matter and antimatter. We show here how this mechanism is realised in a particular BSM theory, the see-saw model, where the quantum loops involve the heavy sterile neutrinos responsible for light neutrino masses. We demonstrate by explicit computation of the relevant two-loop Feynman diagrams how the size of the radiative corrections relevant for leptogenesis becomes enhanced by increasing the mass hierarchy of the sterile neutrinos, and show how the induced lepton asymmetry may be sufficiently large to play an important rôle in determining the baryon-to-photon ratio of the Universe.

  15. Multilayer Strip Dipole Antenna Using Stacking Technique and Its Application for Curved Surface

    Directory of Open Access Journals (Sweden)

    Charinsak Saetiaw

    2013-01-01

    Full Text Available This paper presents the design of multilayer strip dipole antenna by stacking a flexible copper-clad laminate utilized for curved surface on the cylindrical objects. The designed antenna will reduce the effects of curving based on relative lengths that are changed in each stacking flexible copper-clad laminate layer. Curving is different from each layer of the antenna, so the resonance frequency that resulted from an extended antenna provides better frequency response stability compared to modern antenna when it is curved or attached to cylindrical objects. The frequency of multilayer antenna is designed at 920 MHz for UHF RFID applications.

  16. The Impact of the Combination of Circular Curve and Transition Curve on Highway Operation Security

    Directory of Open Access Journals (Sweden)

    Cao Youlu

    2015-07-01

    Full Text Available By investigating the accident in 2009 and 2011 of Taijiu Expressway, the study analyzed the relationship between the horizontal curve radiuses, the length of horizontal curve, the length of transition curve and the number of accidents, established the corresponding regression model. The trend of accidents was determined with different length of transition curve and different combination of circular curve according to this model. The results show that the circular curve radius and length of transition curve increase with the decreases of accidents number, the number of accidents decreases with the increase of the ratio of the length of the transition curve and the length of the round curve. When the ratio of the parameters of the transition curve and the radius of the circle is between 0.3-0.6, the accidents are more focused. The bigger change rate of curves is, there are more accidents of flat curve. To evaluate road traffic safety from the perspective of horizontal curve alignment design, these regularities have very important reference.

  17. Learning curves in energy planning models

    Energy Technology Data Exchange (ETDEWEB)

    Barreto, L.; Kypreos, S. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1999-08-01

    This study describes the endogenous representation of investment cost learning curves into the MARKAL energy planning model. A piece-wise representation of the learning curves is implemented using Mixed Integer Programming. The approach is briefly described and some results are presented. (author) 3 figs., 5 refs.

  18. Curve Matching with Applications in Medical Imaging

    DEFF Research Database (Denmark)

    Bauer, Martin; Bruveris, Martins; Harms, Philipp

    2015-01-01

    In the recent years, Riemannian shape analysis of curves and surfaces has found several applications in medical image analysis. In this paper we present a numerical discretization of second order Sobolev metrics on the space of regular curves in Euclidean space. This class of metrics has several...

  19. Rotation curve of the Milky Way

    Directory of Open Access Journals (Sweden)

    Lee Y.S.

    2012-02-01

    Full Text Available We use SEGUE and Hipparcos data to restrict the behaviour of the rotation curve of the Milky Way in the solar neighbourhood. Then we construct a density model of the Milky Way which best reproduces the available observations of the rotation curve and is consistent with the density constraints in the solar neighbourhood.

  20. Spectral Curves of Operators with Elliptic Coefficients

    Directory of Open Access Journals (Sweden)

    J. Chris Eilbeck

    2007-03-01

    Full Text Available A computer-algebra aided method is carried out, for determining geometric objects associated to differential operators that satisfy the elliptic ansatz. This results in examples of Lamé curves with double reduction and in the explicit reduction of the theta function of a Halphen curve.

  1. Tautological Integrals on Symmetric Products of Curves

    Institute of Scientific and Technical Information of China (English)

    Zhi Lan WANG

    2016-01-01

    We propose a conjecture on the generating series of Chern numbers of tautological bundles on symmetric products of curves and establish the rank 1 and rank −1 case of this conjecture. Thus we compute explicitly the generating series of integrals of Segre classes of tautological bundles of line bundles on curves, which has a similar structure as Lehn’s conjecture for surfaces.

  2. Green's Conjecture for the generic canonical curve

    OpenAIRE

    Teixidor-I-Bigas, Montserrat

    1998-01-01

    Green's Conjecture states the following : syzygies of the canonical model of a curve are simple up to the p^th stage if and only if the Clifford index of C is greater than p. We prove that the generic curve of genus g satisfies Green's conjecture.

  3. Blending Canal Surfaces Based on PH Curves

    Institute of Scientific and Technical Information of China (English)

    Chen-Dong Xu; Fa-Lai Chen

    2005-01-01

    In this paper, a new method for blending two canal surfaces is proposed. The blending surface is itself a generalized canal surface, the spine curve of which is a PH (Pythagorean-Hodograph) curve. The blending surface possesses an attractive property - its representation is rational. The method is extensible to blend general surfaces as long as the blending boundaries are well-defined.

  4. The density curve of F distribution

    Institute of Scientific and Technical Information of China (English)

    LIU Xiaopeng; LIU Kunhui

    2004-01-01

    Employing the properties of special function,we discuss the positional relation between two density curves with different parameters for F distribution in this paper.Some varying regularities about the position of density curve of F distribution have been obtained.

  5. Electrical-Discharge Machining Of Curved Passages

    Science.gov (United States)

    Guirguis, Kamal S.

    1993-01-01

    Electrical-discharge machining (EDM) used to cut deep hole with bends. EDM process done with articulating segmented electrode. Originally straight, electrode curved as it penetrates part, forming long, smoothly curving hole. After hole cut, honed with slurry to remove thin layer of recast metal created by EDM. Breakage of tools, hand deburring, and drilling debris eliminated.

  6. Integrability and the motion of curves

    Science.gov (United States)

    Nakayama, Kazuaki; Segur, Harvey; Wadati, Miki

    1992-11-01

    Recently discovered connections between integrable evolution equations and the motion of curves are based on the following fact: The Serret-Frenet equations are equivalent to the Ablowitz-Kaup-Newell-Segur (AKNS) scattering problem at zero eigenvalue. This equivalence identifies those evolution equations, integrable or not, that can describe the motion of curves.

  7. Constructing forward price curves in electricity markets

    DEFF Research Database (Denmark)

    Fleten, S.-E.; Lemming, Jørgen Kjærgaard

    2003-01-01

    We present and analyze a method for constructing approximated high-resolution forward price curves in electricity markets. Because a limited number of forward or futures contracts are traded in the market, only a limited picture of the theoretical continuous forward price curve is available...

  8. 47 CFR 80.767 - Propagation curve.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Propagation curve. 80.767 Section 80.767... MARITIME SERVICES Standards for Computing Public Coast Station VHF Coverage § 80.767 Propagation curve. The propagation graph, § 80.767 Graph 1, must be used in computing the service area contour. The graph...

  9. Measuring Model Rocket Engine Thrust Curves

    Science.gov (United States)

    Penn, Kim; Slaton, William V.

    2010-01-01

    This paper describes a method and setup to quickly and easily measure a model rocket engine's thrust curve using a computer data logger and force probe. Horst describes using Vernier's LabPro and force probe to measure the rocket engine's thrust curve; however, the method of attaching the rocket to the force probe is not discussed. We show how a…

  10. Modeling Start Curves of Bainite Formation

    NARCIS (Netherlands)

    Van Bohemen, S.M.C.

    2009-01-01

    It is demonstrated that calculations with a physically based model give an accurate description of the start curve of bainite formation in a wide range of steels. The temperature dependence of the overall kinetics, which determines the characteristic C shape of the start curve, is controlled by both

  11. Measuring Model Rocket Engine Thrust Curves

    Science.gov (United States)

    Penn, Kim; Slaton, William V.

    2010-01-01

    This paper describes a method and setup to quickly and easily measure a model rocket engine's thrust curve using a computer data logger and force probe. Horst describes using Vernier's LabPro and force probe to measure the rocket engine's thrust curve; however, the method of attaching the rocket to the force probe is not discussed. We show how a…

  12. Estimates for J-curves as submanifolds

    CERN Document Server

    Fish, Joel W

    2009-01-01

    Here we develop some basic analytic tools to study compactness properties of $J$-curves (i.e. pseudo-holomorphic curves) when regarded as submanifolds. Incorporating techniques from the theory of minimal surfaces, we derive an inhomogeneous mean curvature equation for such curves, we establish an extrinsic monotonicity principle for non-negative functions $f$ satisfying $\\Delta f\\geq -c^2 f$, we show that curves locally parameterized as a graph over a coordinate tangent plane have all derivatives a priori bounded in terms of curvature and ambient geometry, and we establish $\\epsilon$-regularity for the square length of their second fundamental forms. These results are all provided for $J$-curves either with or without Lagrangian boundary and hold in almost Hermitian manifolds of arbitrary even dimension (i.e. Riemannian manifolds for which the almost complex structure is an isometry).

  13. STATIONARY CONNECTED CURVES IN HILBERT SPACES

    Directory of Open Access Journals (Sweden)

    Raed Hatamleh

    2014-01-01

    Full Text Available In this article the structure of non-stationary curves which are stationary connected in Hilbert space is studied using triangular models of non-self-adjoint operator. The concept of evolutionary representability plays here an important role. It is proved that if one of two curves in Hilbert space is evolutionary representable and the curves are stationary connected, then another curve is evolutionary representable too. These curves are studied firstly. The structure of a cross-correlation function in the case when operator, defining the evolutionary representation, has one-dimensional non-Hermitian subspace (the spectrum is discreet and situated in the upper complex half-plane or has infinite multiplicity at zero (Volterra operator is studied.

  14. Generating artificial light curves: Revisited and updated

    CERN Document Server

    Emmanoulopoulos, D; Papadakis, I E

    2013-01-01

    The production of artificial light curves with known statistical and variability properties is of great importance in astrophysics. Consolidating the confidence levels during cross-correlation studies, understanding the artefacts induced by sampling irregularities, establishing detection limits for future observatories are just some of the applications of simulated data sets. Currently, the widely used methodology of amplitude and phase randomisation is able to produce artificial light curves which have a given underlying power spectral density (PSD) but which are strictly Gaussian distributed. This restriction is a significant limitation, since the majority of the light curves e.g. active galactic nuclei, X-ray binaries, gamma-ray bursts show strong deviations from Gaussianity exhibiting `burst-like' events in their light curves yielding long-tailed probability distribution functions (PDFs). In this study we propose a simple method which is able to precisely reproduce light curves which match both the PSD an...

  15. Remote sensing used for power curves

    Science.gov (United States)

    Wagner, R.; Jørgensen, H. E.; Paulsen, U. S.; Larsen, T. J.; Antoniou, I.; Thesbjerg, L.

    2008-05-01

    : Power curve measurement for large wind turbines requires taking into account more parameters than only the wind speed at hub height. Based on results from aerodynamic simulations, an equivalent wind speed taking the wind shear into account was defined and found to reduce the power standard deviation in the power curve significantly. Two LiDARs and a SoDAR are used to measure the wind profile in front of a wind turbine. These profiles are used to calculate the equivalent wind speed. The comparison of the power curves obtained with the three instruments to the traditional power curve, obtained using a cup anemometer measurement, confirms the results obtained from the simulations. Using LiDAR profiles reduces the error in power curve measurement, when these are used as relative instrument together with a cup anemometer. Results from the SoDAR do not show such promising results, probably because of noisy measurements resulting in distorted profiles.

  16. Curved and conformal high-pressure vessel

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, Paul F.; Kuczek, Andrzej E.; Zhao, Wenping

    2016-10-25

    A high-pressure vessel is provided. The high-pressure vessel may comprise a first chamber defined at least partially by a first wall, and a second chamber defined at least partially by the first wall. The first chamber and the second chamber may form a curved contour of the high-pressure vessel. A modular tank assembly is also provided, and may comprise a first mid tube having a convex geometry. The first mid tube may be defined by a first inner wall, a curved wall extending from the first inner wall, and a second inner wall extending from the curved wall. The first inner wall may be disposed at an angle relative to the second inner wall. The first mid tube may further be defined by a short curved wall opposite the curved wall and extending from the second inner wall to the first inner wall.

  17. AHT Bézier Curves and NUAHT B-Spline Curves

    Institute of Scientific and Technical Information of China (English)

    Gang Xu; Guo-Zhao Wang

    2007-01-01

    In this paper, we present two new unified mathematics models of conics and polynomial curves, called algebraic hyperbolic trigonometric ( AHT) Bézier curves and non-uniform algebraic hyperbolic trigonometric ( NUAHT) B-sptine curves of order n, which are generated over the space span{sin t, cos t, sinh t, cosh t, 1, t,..., tn-5}, n ≥ 5. The two kinds of curves share most of the properties as those of the Bézier curves and B-spline curves in polynomial space. In particular, they can represent exactly some remarkable transcendental curves such as the helix, the cycloid and the catenary. The subdivision formulae of these new kinds of curves are also given. The generations of the tensor product surfaces are straightforward. Using the new mathematics models, we present the control mesh representations of two classes of minimal surfaces.

  18. Unifying representation of Bézier curve and two kinds of generalized ball curves

    Institute of Scientific and Technical Information of China (English)

    ZHU Xiaolin; WANG Zhihua

    2012-01-01

    This paper presents a new basis, the WSB basis, which unifies the Bemstein basis, Wang-Ball basis and Said-Ball basis, and therefore the Bézier curve, Wang-Ball curve and Said-Ball curve are the special cases of the WSB curve based on the WSB basis In addition, the relative degree elevation formula, recursive algorithm and conversion formula between the WSB basis and the Bern- stein basis are given.

  19. Dissection of the hormetic curve: analysis of components and mechanisms.

    Science.gov (United States)

    Lushchak, Volodymyr I

    2014-07-01

    The relationship between the dose of an effector and the biological response frequently is not described by a linear function and, moreover, in some cases the dose-response relationship may change from positive/adverse to adverse/positive with increasing dose. This complicated relationship is called "hormesis". This paper provides a short analysis of the concept along with a description of used approaches to characterize hormetic relationships. The whole hormetic curve can be divided into three zones: I - a lag-zone where no changes are observed with increasing dose; II - a zone where beneficial/adverse effects are observed, and III - a zone where the effects are opposite to those seen in zone II. Some approaches are proposed to analyze the molecular components involved in the development of the hormetic character of dose-response relationships with the use of specific genetic lines or inhibitors of regulatory pathways. The discussion is then extended to suggest a new parameter (half-width of the hormetic curve at zone II) for quantitative characterization of the hormetic curve. The problems limiting progress in the development of the hormesis concept such as low reproducibility and predictability may be solved, at least partly, by deciphering the molecular mechanisms underlying the hormetic dose-effect relationship.

  20. 肋环型单层曲板网壳结构的风振响应及等效静风荷载%Wind-induced response and equivalent static wind load of single-layer Geiger lattice shell with curved plate

    Institute of Scientific and Technical Information of China (English)

    冯若强; 丁静鹄; 李庆祥; 叶继红

    2012-01-01

    The wind pressure and the wind-induced vibration of a single-layer Geiger lattice shell with curved plate are analyzed. Different methods are used to calculate the equivalent static wind load, and the calculation accuracy are compared. The results of the wind tunnel experiment show that the wind pressure is mostly negative on the single-layer Geiger lattice shell with curved plate. But under the 90° wind direction, because of the flow obstruction of the front building, the positive pressure appears on some area of the roof s edge. The wind-induced response analysis results show that many modes make contribution to the structural wind-induced response, and the higher modes should be considered. Subjected to the fluctuating wind load, the mode coupling should be considered in order to obtain a good accuracy of the wind-induced response for all the structural nodes. If only the accuracy of the larger displacement is needed, the square root sum of square(SRSS) method which ignores the mode coupling can be also used. It is found that both the load-response correlation (LRC) with inertia force method and the modified LRC method for calculating the equivalent static wind load of the single-layer Geiger lattice shell with curved plate can ensure the equivalence of the largest displacements rather than all the nodal displacements.%分析了肋环型单层曲板网壳结构的风荷载和风振响应,并对采用不同方法计算结构等效静风荷载的精度进行了比较.风洞试验结果表明:肋环型单层曲板网壳结构屋面主要受负风压作用;但在90°风向角下,由于体育馆受前方入口建筑的影响,屋盖边缘局部出现正风压.风振响应分析结果表明:有多阶振型参与结构的风致振动,高阶模态影响不可忽略;为保证结构表面所有节点位移准确,结构的模态耦合项不能忽略.但如果只保证较大位移处的准确性,忽略模态耦合项的SRSS方法也是可取的.利用LRC惯性力法和

  1. Three-body choreographies in given curves

    Energy Technology Data Exchange (ETDEWEB)

    Ozaki, Hiroshi [General Education Program Center, Tokai University, 317 Nishino, Numazu, Shizuoka 410-0395 (Japan); Fukuda, Hiroshi; Fujiwara, Toshiaki [College of Liberal Arts and Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555 (Japan)], E-mail: ozaki@keyaki.cc.u-tokai.ac.jp, E-mail: fukuda@kitasato-u.ac.jp, E-mail: fujiwara@kitasato-u.ac.jp

    2009-10-02

    As shown by Johannes Kepler in 1609, in the two-body problem, the shape of the orbit, a given ellipse, and a given non-vanishing constant angular momentum determine the motion of the planet completely. Even in the three-body problem, in some cases, the shape of the orbit, conservation of the center of mass and a constant of motion (the angular momentum or the total energy) determine the motion of the three bodies. We show, by a geometrical method, that choreographic motions, in which equal mass three bodies chase each other around the same curve, will be uniquely determined for the following two cases. (i) Convex curves that have point symmetry and non-vanishing angular momentum are given. (ii) Eight-shaped curves which are similar to the curve for the figure-eight solution and the energy constant are given. The reality of the motion should be tested whether the motion satisfies an equation of motion or not. Extensions of the method for generic curves are shown. The extended methods are applicable to generic curves which do not have point symmetry. Each body may have its own curve and its own non-vanishing masses.

  2. Investigation of learning and experience curves

    Energy Technology Data Exchange (ETDEWEB)

    Krawiec, F.; Thornton, J.; Edesess, M.

    1980-04-01

    The applicability of learning and experience curves for predicting future costs of solar technologies is assessed, and the major test case is the production economics of heliostats. Alternative methods for estimating cost reductions in systems manufacture are discussed, and procedures for using learning and experience curves to predict costs are outlined. Because adequate production data often do not exist, production histories of analogous products/processes are analyzed and learning and aggregated cost curves for these surrogates estimated. If the surrogate learning curves apply, they can be used to estimate solar technology costs. The steps involved in generating these cost estimates are given. Second-generation glass-steel and inflated-bubble heliostat design concepts, developed by MDAC and GE, respectively, are described; a costing scenario for 25,000 units/yr is detailed; surrogates for cost analysis are chosen; learning and aggregate cost curves are estimated; and aggregate cost curves for the GE and MDAC designs are estimated. However, an approach that combines a neoclassical production function with a learning-by-doing hypothesis is needed to yield a cost relation compatible with the historical learning curve and the traditional cost function of economic theory.

  3. Tracking stochastic resonance curves using an assisted reference model

    Energy Technology Data Exchange (ETDEWEB)

    Calderón Ramírez, Mario; Rico Martínez, Ramiro [Departamento de Ingeniería Química, Instituto Tecnológico de Celaya, Av. Tecnológico y A. García Cubas S/N, Celaya, Guanajuato, 38010 (Mexico); Ramírez Álvarez, Elizeth [Nonequilibrium Chemical Physics, Physik-Department, TU-München, James-Franck-Str. 1, 85748 Garching bei München (Germany); Parmananda, P. [Department of Physics, Indian Institute of Technology Bombay, Powai, Mumbai 400 076 (India)

    2015-06-15

    The optimal noise amplitude for Stochastic Resonance (SR) is located employing an Artificial Neural Network (ANN) reference model with a nonlinear predictive capability. A modified Kalman Filter (KF) was coupled to this reference model in order to compensate for semi-quantitative forecast errors. Three manifestations of stochastic resonance, namely, Periodic Stochastic Resonance (PSR), Aperiodic Stochastic Resonance (ASR), and finally Coherence Resonance (CR) were considered. Using noise amplitude as the control parameter, for the case of PSR and ASR, the cross-correlation curve between the sub-threshold input signal and the system response is tracked. However, using the same parameter the Normalized Variance curve is tracked for the case of CR. The goal of the present work is to track these curves and converge to their respective extremal points. The ANN reference model strategy captures and subsequently predicts the nonlinear features of the model system while the KF compensates for the perturbations inherent to the superimposed noise. This technique, implemented in the FitzHugh-Nagumo model, enabled us to track the resonance curves and eventually locate their optimal (extremal) values. This would yield the optimal value of noise for the three manifestations of the SR phenomena.

  4. Analysis and Design of Stimulus Response Curves of E. coli

    Directory of Open Access Journals (Sweden)

    Andreas Kremling

    2012-11-01

    Full Text Available Metabolism and signalling are tightly coupled in bacteria. Combining several theoretical approaches, a core model is presented that describes transcriptional and allosteric control of glycolysis in Escherichia coli. Experimental data based on microarrays, signalling components and extracellular metabolites are used to estimate kinetic parameters. A newly designed strain was used that adjusts the incoming glucose flux into the system and allows a kinetic analysis. Based on the results, prediction for intracelluar metabolite concentrations over a broad range of the growth rate could be performed and compared with data from literature.

  5. The antiproton depth–dose curve measured with alanine detectors

    CERN Document Server

    Bassler, Niels; Palmans, Hugo; Holzscheiter, Michael H; Kovacevic, Sandra

    2008-01-01

    n this paper we report on the measurement of the antiproton depth–dose curve, with alanine detectors. The results are compared with simulations using the particle energy spectrum calculated by FLUKA, and using the track structure model of Hansen and Olsen for conversion of calculated dose into response. A good agreement is observed between the measured and calculated relative effectiveness although an underestimation of the measured values beyond the Bragg-peak remains unexplained. The model prediction of response of alanine towards heavy charged particles encourages future use of the alanine detectors for dosimetry of mixed radiation fields.

  6. Supersonic Flutter of Laminated Curved Panels

    Directory of Open Access Journals (Sweden)

    M. Ganapathi

    1995-04-01

    Full Text Available Supersonic flutter analysis of laminated composite curved panels is investigated using doubly-curved, quadrilateral, shear flexible, shell element based on field-consistency approach. The formulation includes transverse shear deformation, in-plane and rotary inertias. The aerodynamic force is evaluated using two-dimensional static aerodynamic approximation for high supersonic flow. Initially, the model developed here is verified for the flutter analysis of flat plates. Numerical results are presented for isotropic, orthotropic and laminated anisotropic curved panels. A detailed parametric study is carried out to observe the effects of aspect and thickness ratios, number of layers, lamination scheme, and boundary conditions on flutter boundary.

  7. Mapping curved spacetimes into Dirac spinors

    CERN Document Server

    Sabín, Carlos

    2016-01-01

    We show how to transform a Dirac equation in curved spacetime into a Dirac equation in flat spacetime. In particular, we show that any solution of the free massless Dirac equation in a 1+1 dimensional flat spacetime can be transformed via a local phase transformation into a solution of the corresponding Dirac equation in a curved background, where the spacetime metric is encoded into the phase. In this way, the existing quantum simulators of the Dirac equation can naturally incorporate curved spacetimes. As a first example we use our technique to obtain solutions of the Dirac equation in a particular family of interesting spacetimes in 1+1 dimensions.

  8. Magnetization curve modelling of soft magnetic alloys

    Energy Technology Data Exchange (ETDEWEB)

    Meszaros, I, E-mail: meszaros@eik.bme.hu [Department of Materials Science and Engineering, Budapest University of Technology and Economics, Bertalan L. street 7., Budapest, H-1111 (Hungary)

    2011-01-01

    In this paper we present an application of the so called hyperbolic model of magnetization. The model was modified and it was applied for nine different soft magnetic alloys. The tested samples were electro-technical steels (FeSi alloys) and a permalloy (FeNi alloy) with strongly different magnetic properties. Among them there are top, medium and definitely poor quality soft magnetic materials as well. Their minor hysteresis loops and normal magnetization curves were measured by alternating current measurement. The hyperbolic model of magnetization was applied for the experimental normal magnetization curves. It was proved that the applied model is excellent for describing mathematically the experimental magnetization curves.

  9. CRC standard curves and surfaces with Mathematica

    CERN Document Server

    von Seggern, David H

    2006-01-01

    Since the publication of the first edition, Mathematica® has matured considerably and the computing power of desktop computers has increased greatly. This enables the presentation of more complex curves and surfaces as well as the efficient computation of formerly prohibitive graphical plots. Incorporating both of these aspects, CRC Standard Curves and Surfaces with Mathematica®, Second Edition is a virtual encyclopedia of curves and functions that depicts nearly all of the standard mathematical functions rendered using Mathematica. While the easy-to-use format remains unchanged from the previ

  10. Curves and surfaces in the context of optometry. Part 1: Curves*

    OpenAIRE

    2005-01-01

    This paper introduces the differential geom-etry of curves in Euclidean 3-space, the motiva-tion being the writer’s belief that, despite their fundamental importance, curves are inadequate-ly treated in optometric educational programs. Curvature and torsion are defined along a curve. Two  numerical  examples  are  presented.  The fundamental theorem of curves is stated. The relationship of the geometry of varifocal lenses and curves known as involutes are discussed. A brief treatment of the t...

  11. Quantum Curves and $D$-Modules

    CERN Document Server

    Dijkgraaf, Robbert; Sulkowski, Piotr

    2009-01-01

    In this article we continue our study of chiral fermions on a quantum curve. This system is embedded in string theory as an I-brane configuration, which consists of D4 and D6-branes intersecting along a holomorphic curve in a complex surface, together with a B-field. Mathematically, it is described by a holonomic D-module. Here we focus on spectral curves, which play a prominant role in the theory of (quantum) integrable hierarchies. We show how to associate a quantum state to the I-brane system, and subsequently how to compute quantum invariants. As a first example, this yields an insightful formulation of (double scaled as well as general Hermitian) matrix models. Secondly, our formalism elegantly reconstructs the complete dual Nekrasov-Okounkov partition function from a quantum Seiberg-Witten curve.

  12. Quantum curves and Script D-modules

    Science.gov (United States)

    Dijkgraaf, Robbert; Hollands, Lotte; Sułkowski, Piotr

    2009-11-01

    In this article we continue our study of chiral fermions on a quantum curve. This system is embedded in string theory as an I-brane configuration, which consists of D4 and D6-branes intersecting along a holomorphic curve in a complex surface, together with a B-field. Mathematically, it is described by a holonomic Script D-module. Here we focus on spectral curves, which play a prominent role in the theory of (quantum) integrable hierarchies. We show how to associate a quantum state to the I-brane system, and subsequently how to compute quantum invariants. As a first example, this yields an insightful formulation of (double scaled as well as general Hermitian) matrix models. Secondly, we formulate c = 1 string theory in this language. Finally, our formalism elegantly reconstructs the complete dual Nekrasov-Okounkov partition function from a quantum Seiberg-Witten curve.

  13. Relation among C-curve characterization diagrams

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    As three control points are fixed and the fourth control point varies, the planar cubic C-curve may take on a loop, a cusp, or zero to two inflection points, depending on the position of the moving point. The plane can, therefore, be partitioned into regions labelled according to the characterization of the curve when the fourth point is in each region. This partitioned plane is called a "characterization diagram". By moving one of the control points but fixing the rest, one can induce different characterization diagrams. In this paper, we investigate the relation among all different characterization diagrams of cubic C-curves based on the singularity conditions proposed by Yang and Wang (2004). We conclude that, no matter what the C-curve type is or which control point varies, the characterization diagrams can be obtained by cutting a common 3D characterization space with a corresponding plane.

  14. Holomorphic Cartan geometries and rational curves

    CERN Document Server

    Biswas, Indranil

    2010-01-01

    We prove that any compact K\\"ahler manifold bearing a holomorphic Cartan geometry contains a rational curve just when the Cartan geometry is inherited from a holomorphic Cartan geometry on a lower dimensional compact K\\"ahler manifold.

  15. Transmission of wave energy in curved ducts

    Science.gov (United States)

    Rostafinski, W.

    1973-01-01

    A formation of wave energy flow was developed for motion in curved ducts. A parametric study over a range of frequencies determined the ability of circular bends to transmit energy for the case of perfectly rigid walls.

  16. Halpha rotation curves the soft core question

    CERN Document Server

    Marchesini, D; Chincarini, G L; Firmani, C; Conconi, P; Molinari, E; Zacchei, A

    2002-01-01

    We present good resolution Halpha rotation curves of 6 galaxies: late-type dwarf and low surface brightness galaxies (LSB) for which accurate HI rotation curves are available from the literature. Observations are carried out at Telescopio Nazionale Galileo (TNG). For LSB F583-1 an innovative dispersing element was used, the Volume Phase Holographic (VPH) with a dispersion of about 0.35 A pxl^{-1}. From our analysis we find good agreement between the Halpha data and the HI observations concluding that the HI data for these galaxies suffer very little from beam smearing. We show that the optical rotation curves of these dark matter dominated galaxies are best fitted by the Burkert profile. In the center of galaxies, where the N-body simulations predict cusp cores and fast rising rotation curves, our data seem to be in better agreement with the presence of soft cores.

  17. Twisted Vector Bundles on Pointed Nodal Curves

    Indian Academy of Sciences (India)

    Ivan Kausz

    2005-05-01

    Motivated by the quest for a good compactification of the moduli space of -bundles on a nodal curve we establish a striking relationship between Abramovich’s and Vistoli’s twisted bundles and Gieseker vector bundles.

  18. Automorphisms of double coverings of curves

    CERN Document Server

    Torres, F

    1994-01-01

    We study automorphisms of curves that commute with each other. We prove that the order and the number of fixed points of one of them satisfy certain relations involving those of the other. Then, we specialize our results to the case of double coverings of curves. For instance, if the genus of the curve is at least 4\\gamma+2 and \\gamma \\geqq 1 (\\gamma = the genus of the covered curve) we prove that the order of an automorphism is bounded above by 2\\gamma+1 (resp. 4\\gamma+2) provided it is prime (resp. it has at least five fixed points). We also improve Farkas' bound on the number of fixed points namely 4\\gamma+4 by showing that it involves the order of the automorphism except in the case of even order when such an improvement is obtained provided the automorphism and the \\gamma-involution has at least one common fixed point.

  19. ARC Code TI: ROC Curve Code Augmentation

    Data.gov (United States)

    National Aeronautics and Space Administration — ROC (Receiver Operating Characteristic) curve Code Augmentation was written by Rodney Martin and John Stutz at NASA Ames Research Center and is a modification of ROC...

  20. KAIT Fermi AGN Light-Curve Reservoir

    Data.gov (United States)

    National Aeronautics and Space Administration — This web page shows the light curves of a total of 163 AGNs that are monitored by KAIT with average cadence of 3 days. These are unfiltered observations; in...