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Sample records for grip tool pgt

  1. Gripping tool for the ITER upper port plug RH extraction/insertion

    Energy Technology Data Exchange (ETDEWEB)

    Rosa, Elena V., E-mail: elena.rosa@ciemat.es; Ríos, Luis, E-mail: luis.rios@ciemat.es

    2014-10-15

    Highlights: •The gripping tool is based on only one gripping point centred at the plug bottom. •The gripping tool should allow the relative displacement in the gripping point to absorb the misalignment between plug and tractor. •The gripping tool needs to withstand around 100/30 kN during the plug extraction/insertion. •The gripping tool should rely on visual control and it has to avoid force feed-back. •The comparison between the features of several gripping tool concepts is assessed. -- Abstract: The conceptual design of several gripping tools and their mechanical interfaces is being carried out for the ITER ECH UPP within the WP10-GOTRH programme. EFDA finances the GOT RH (Goal Oriented Training Programme for Remote Handling). The purpose of this paper is to introduce new concepts of gripping tools for the plug extraction/insertion in the upper port of ITER. All these gripping tools are designed according to IO input data and geometrical constraints. The gripping tools have to be able to extract/insert the plug in the scenario of maximum misalignment between the plug and the tractor. The paper also defines the functional requirements the gripping tools need to comply with. The requirements and input data are verified and validated through 3D simulation with Catia mock-ups of the gripping tools. The strengths and weaknesses of each gripping tool model are compared.

  2. Maximal intermittent handgrip strategy: design and evaluation of an exercise protocol and a grip tool.

    Science.gov (United States)

    Bentley, Danielle Christine; Thomas, Scott Gordon

    2016-01-01

    Handgrip (HG) exercise has been prescribed as a lifestyle intervention to successfully reduce resting blood pressure (BP) among heterogeneous groups of participants. Current HG protocols have limited accessibility due to complicated exercise prescriptions and sophisticated required equipment. Therefore, this research describes the design and evaluation of the maximal intermittent (MINT) HG exercise strategy, consisting of both a novel exercise protocol (32×5 seconds maximal grip squeezes separated by 5 seconds of rest between sets) and an original grip tool. This research was a multistep progressive design that included 51 postmenopausal women as participants in three separate research studies. Part 1 of this research focuses on the MINT exercise protocol. A literature-informed rationale for the design of the protocol is described. This includes exercise intensity, work-to-rest ratio, and total exercise duration with reference to the unique physiology (mechanoreflex and metaboreflex) of postmenopausal women. Subsequent experimental analyses of acute responses to the MINT protocol revealed that women produced 50% of their maximum grip force with moderate cardiovascular responses (increases of systolic BP: 41.6 mmHg, diastolic BP: 20.1 mmHg, heart rate: 35.1 bpm) that remained far below the thresholds of concern identified by the American College of Sports Medicine. Part 2 of this research describes the creation of a novel grip tool, beginning with a mixed-methods assessment of participant opinions regarding two distinct in-laboratory grip tools, leading to the creation of four prototype MINT tools. Structured focus groups revealed a strong preference for MINT prototype 1 for all tool design features, including color, shape, size, and foam grip. Collectively, the result of this multistep research is a novel HG exercise strategy with enhanced accessibility by being easy to understand and simple to execute. The long-term training effectiveness of MINT as an exercise

  3. Maximal intermittent handgrip strategy: design and evaluation of an exercise protocol and a grip tool

    Directory of Open Access Journals (Sweden)

    Bentley DC

    2016-05-01

    Full Text Available Danielle Christine Bentley, Scott Gordon Thomas Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada Abstract: Handgrip (HG exercise has been prescribed as a lifestyle intervention to successfully reduce resting blood pressure (BP among heterogeneous groups of participants. Current HG protocols have limited accessibility due to complicated exercise prescriptions and sophisticated required equipment. Therefore, this research describes the design and evaluation of the maximal intermittent (MINT HG exercise strategy, consisting of both a novel exercise protocol (32×5 seconds maximal grip squeezes separated by 5 seconds of rest between sets and an original grip tool. This research was a multistep progressive design that included 51 postmenopausal women as participants in three separate research studies. Part 1 of this research focuses on the MINT exercise protocol. A literature-informed rationale for the design of the protocol is described. This includes exercise intensity, work-to-rest ratio, and total exercise duration with reference to the unique physiology (mechanoreflex and metaboreflex of postmenopausal women. Subsequent experimental analyses of acute responses to the MINT protocol revealed that women produced 50% of their maximum grip force with moderate cardiovascular responses (increases of systolic BP: 41.6 mmHg, diastolic BP: 20.1 mmHg, heart rate: 35.1 bpm that remained far below the thresholds of concern identified by the American College of Sports Medicine. Part 2 of this research describes the creation of a novel grip tool, beginning with a mixed-methods assessment of participant opinions regarding two distinct in-laboratory grip tools, leading to the creation of four prototype MINT tools. Structured focus groups revealed a strong preference for MINT prototype 1 for all tool design features, including color, shape, size, and foam grip. Collectively, the result of this multistep

  4. Biomimetics approach for methods to release microobjects from the gripping tool

    DEFF Research Database (Denmark)

    Gegeckaite, Asta; Moon, Jack; Hansen, Hans Nørgaard

    2005-01-01

    In the micro scale, gripping devices are working in the different way. New forces, working in the micro scale, like van der Waals, surface tension and electrostatics are influencing the gripping process. Handling of micro or even nano sized objects can be easily in the nature. Different types of ...

  5. Biomimetics approach for methods to release microobjects from the gripping tool

    DEFF Research Database (Denmark)

    Gegeckaite, Asta; Moon, Jack; Hansen, Hans Nørgaard

    2005-01-01

    In the micro scale, gripping devices are working in the different way. New forces, working in the micro scale, like van der Waals, surface tension and electrostatics are influencing the gripping process. Handling of micro or even nano sized objects can be easily in the nature. Different types of ...

  6. GRiP: a computational tool to simulate transcription factor binding in prokaryotes.

    Science.gov (United States)

    Zabet, Nicolae Radu; Adryan, Boris

    2012-05-01

    Transcription factors (TFs) are proteins that regulate gene activity by binding to specific sites on the DNA. Understanding the way these molecules locate their target site is of great importance in understanding gene regulation. We developed a comprehensive computational model of this process and estimated the model parameters in (N.R.Zabet and B.Adryan, submitted for publication). GRiP (gene regulation in prokaryotes) is a highly versatile implementation of this model and simulates the search process in a computationally efficient way. This program aims to provide researchers in the field with a flexible and highly customizable simulation framework. Its features include representation of DNA sequence, TFs and the interaction between TFs and the DNA (facilitated diffusion mechanism), or between various TFs (cooperative behaviour). The software will record both information on the dynamics associated with the search process (locations of molecules) and also steady-state results (affinity landscape, occupancy-bias and collision hotspots). http://logic.sysbiol.cam.ac.uk/grip, program and source code

  7. GRIPS Plan

    Energy Technology Data Exchange (ETDEWEB)

    1978-07-31

    The GRIPS (Geothermal Resources Impact Projection Study) Commission was established by a Joint Powers Agreement between the California Counties of Lake, Mendocino, Napa, and Sonoma. The objectives of GRIPS are primarily to develop and use a cooperative environmental data collection and use system including natural, social, and economic considerations to facilitate their independent decisions and those of State and Federal agencies related to the environmental effects of geothermal development. This GRIPS Plan was prepared from a wide range of studies, workshops, and staff analyses. The plan is presented in four parts: summary and introduction; environmental data status report; planned programs; and budget. (MHR)

  8. GRIPS bibliography

    Energy Technology Data Exchange (ETDEWEB)

    1978-07-31

    This GRIPS (Geothermal Resources Impact Project Study) contains over 1700 references on a wide variety of subjects dealing directly or indirectly with geothermal development at the Geysers/Calistoga KGRA. (MHR)

  9. Effects of hyperthyroidism on hand grip strength and function.

    Science.gov (United States)

    Erkol İnal, Esra; Çarlı, Alparslan Bayram; Çanak, Sultan; Aksu, Oğuzhan; Köroğlu, Banu Kale; Savaş, Serpil

    2015-01-01

    Hyperthyroidism is a pathologic condition in which the body is exposed to excessive amounts of circulating thyroid hormones. Skeletal muscle is one of the major target organs of thyroid hormones. We evaluated hand grip strength and function in patients with overt hyperthyroidism. Fifty-one patients newly diagnosed with hyperthyroidism and 44 healthy controls participated in this study. Age, height, weight, and dominant hand of all participants were recorded. The diagnosis of hyperthyroidism was confirmed by clinical examination and laboratory tests. Hand grip strength was tested at the dominant hand with a Jamar hand dynamometer. The grooved pegboard test (PGT) was used to evaluate hand dexterity. The Duruöz Hand Index (DHI) was used to assess hand function. No significant differences were found in terms of clinical and demographic findings between the patients with hyperthyroidism and healthy controls (p > 0.05). Significant differences were found between the patients with hyperthyroidism and healthy controls regarding PGT and DHI scores (p Hyperthyroidism seemed to affect hand dexterity and function more than hand grip strength and seemed to be associated with reduced physical function more than muscle strength. This may also indicate that patients with hyperthyroidism should be evaluated by multidisplinary modalities.

  10. Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.

    Directory of Open Access Journals (Sweden)

    Yuling Chi

    Full Text Available Inhibiting the synthesis of endogenous prostaglandins with nonsteroidal anti-inflammatory drugs exacerbates arterial hypertension. We hypothesized that the converse, i.e., raising the level of endogenous prostaglandins, might have anti-hypertensive effects. To accomplish this, we focused on inhibiting the prostaglandin transporter PGT (SLCO2A1, which is the obligatory first step in the inactivation of several common PGs. We first examined the role of PGT in controlling arterial blood pressure blood pressure using anesthetized rats. The high-affinity PGT inhibitor T26A sensitized the ability of exogenous PGE2 to lower blood pressure, confirming both inhibition of PGT by T26A and the vasodepressor action of PGE2 T26A administered alone to anesthetized rats dose-dependently lowered blood pressure, and did so to a greater degree in spontaneously hypertensive rats than in Wistar-Kyoto control rats. In mice, T26A added chronically to the drinking water increased the urinary excretion and plasma concentration of PGE2 over several days, confirming that T26A is orally active in antagonizing PGT. T26A given orally to hypertensive mice normalized blood pressure. T26A increased urinary sodium excretion in mice and, when added to the medium bathing isolated mouse aortas, T26A increased the net release of PGE2 induced by arachidonic acid, inhibited serotonin-induced vasoconstriction, and potentiated vasodilation induced by exogenous PGE2. We conclude that pharmacologically inhibiting PGT-mediated prostaglandin metabolism lowers blood pressure, probably by prostaglandin-induced natriuresis and vasodilation. PGT is a novel therapeutic target for treating hypertension.

  11. Effect of elbow flexion, forearm rotation and upper arm abduction on MVC grip and grip endurance time.

    Science.gov (United States)

    Farooq, Mohd; Khan, Abid Ali

    2012-01-01

    This experiment was designed to know the effect of upper limb postural deviations on grip strength and grip endurance time. A full factorial design of experiment, i.e., 3 (0°, 45°, 90° abduction angles of upper arm) × 3 (45°, 90°, 135° angles of elbow flexion) × 3 (0°, -60° prone, +60° supine angles of forearm rotation) was used to find the effect of 27 combinations of postures on maximum voluntary contraction (MVC) grip strength and grip endurance time. The results showed that none of the main factors were significant on MVC grip, although there was a change in MVC grip. Grip endurance time significantly decreased with an increase in upper arm abduction. Also, grip endurance significantly increased with the elbow flexion angle and decreased with forearm rotation from neutral. These data will help designers and engineers to improve the workplace and tools to reduce the risk of injuries.

  12. Domo-Grip: functional evaluation and rehabilitation using grip force.

    Science.gov (United States)

    Hewson, David J; Li, Ke; Frerejean, Alexis; Hogrel, Jean-Yves; Duchene, Jacques

    2010-01-01

    Grip force measurement is routinely used to identify pathologies, evaluate muscular function, and as part of rehabilitation. Grip force has also been shown to be a good indicator of the capacity of elderly to live independently owing to its strong relationship with clinical tests such as the Index of Activities of Daily Living. An autonomous, communicant grip-force measurement device is presented in this paper in order to perform grip-force evaluation at home. The Domo-Grip system consists of the Grip-Ball, the Grip-Box, and Grip-Soft. The Grip-Ball measures the pressure resulting from grip force, the Grip-Box serves as the communication hub, while Grip-Soft is an interactive software suite. The Domo-Grip system can be used as part of a home-based rehabilitation, and also for functional evaluation as part of an assessment of the capacity of elderly to live autonomously.

  13. The effect of force feedback delay on stiffness perception and grip force modulation during tool-mediated interaction with elastic force fields.

    Science.gov (United States)

    Leib, Raz; Karniel, Amir; Nisky, Ilana

    2015-05-01

    During interaction with objects, we form an internal representation of their mechanical properties. This representation is used for perception and for guiding actions, such as in precision grip, where grip force is modulated with the predicted load forces. In this study, we explored the relationship between grip force adjustment and perception of stiffness during interaction with linear elastic force fields. In a forced-choice paradigm, participants probed pairs of virtual force fields while grasping a force sensor that was attached to a haptic device. For each pair, they were asked which field had higher level of stiffness. In half of the pairs, the force feedback of one of the fields was delayed. Participants underestimated the stiffness of the delayed field relatively to the nondelayed, but their grip force characteristics were similar in both conditions. We analyzed the magnitude of the grip force and the lag between the grip force and the load force in the exploratory probing movements within each trial. Right before answering which force field had higher level of stiffness, both magnitude and lag were similar between delayed and nondelayed force fields. These results suggest that an accurate internal representation of environment stiffness and time delay was used for adjusting the grip force. However, this representation did not help in eliminating the bias in stiffness perception. We argue that during performance of a perceptual task that is based on proprioceptive feedback, separate neural mechanisms are responsible for perception and action-related computations in the brain.

  14. Functional connectivity associated with hand shape generation: Imitating novel hand postures and pantomiming tool grips challenge different nodes of a shared neural network.

    Science.gov (United States)

    Vingerhoets, Guy; Clauwaert, Amanda

    2015-09-01

    Clinical research suggests that imitating meaningless hand postures and pantomiming tool-related hand shapes rely on different neuroanatomical substrates. We investigated the BOLD responses to different tasks of hand posture generation in 14 right handed volunteers. Conjunction and contrast analyses were applied to select regions that were either common or sensitive to imitation and/or pantomime tasks. The selection included bilateral areas of medial and lateral extrastriate cortex, superior and inferior regions of the lateral and medial parietal lobe, primary motor and somatosensory cortex, and left dorsolateral prefrontal, and ventral and dorsal premotor cortices. Functional connectivity analysis revealed that during hand shape generation the BOLD-response of every region correlated significantly with every other area regardless of the hand posture task performed, although some regions were more involved in some hand postures tasks than others. Based on between-task differences in functional connectivity we predict that imitation of novel hand postures would suffer most from left superior parietal disruption and that pantomiming hand postures for tools would be impaired following left frontal damage, whereas both tasks would be sensitive to inferior parietal dysfunction. We also unveiled that posterior temporal cortex is committed to pantomiming tool grips, but that the involvement of this region to the execution of hand postures in general appears limited. We conclude that the generation of hand postures is subserved by a highly interconnected task-general neural network. Depending on task requirements some nodes/connections will be more engaged than others and these task-sensitive findings are in general agreement with recent lesion studies.

  15. Inhibition of Prostaglandin Transporter (PGT Promotes Perfusion and Vascularization and Accelerates Wound Healing in Non-Diabetic and Diabetic Rats.

    Directory of Open Access Journals (Sweden)

    Zhongbo Liu

    Full Text Available Peripheral ischemia, resulting from diminished arterial flow and defective local vascularization, is one of the main causes of impaired wound healing in diabetes. Vasodilatory prostaglandins (PGs, including PGE2 and PGI2, regulate blood flow in peripheral tissues. PGs also stimulate angiogenesis by inducing vascular endothelial growth factor. However, PG levels are reduced in diabetes mainly due to enhanced degradation. We hypothesized that inhibition of the prostaglandin transporter (PGT (SLCO2A1, which mediates the degradation of PGs, would increase blood flow and stimulate vascularization, thereby mitigating peripheral ischemia and accelerating wound healing in diabetes. Here we report that inhibiting PGT with intravenously injected PGT inhibitor, T26A, increased blood flow in ischemic hind limbs created in non-diabetic rats and streptozotocin induced diabetic rats. Systemic, or combined with topical, T26A accelerated closure of cutaneous wounds. Immunohistochemical examination revealed that inhibition of PGT enhanced vascularization (marked by larger numbers of vessels formed by CD34+ cells, and accelerated re-epithelialization of cutaneous wounds. In cultured primary human bone marrow CD34+ cells and human epidermal keratinocytes (HEKs either inhibiting or silencing PGT increased migration in both cell lines. Thus PGT directly regulates mobilization of endothelial progenitor cells (EPCs and HEKs, which could contribute to PGT-mediated vascularization and re-epithelialization. At the molecular level, systemic inhibition of PGT raised circulating PGE2. Taken together, our data demonstrate that PGT modulates arterial blood flow, mobilization of EPCs and HEKs, and vascularization and epithelialization in wound healing by regulating vasodilatory and pro-angiogenic PGs.

  16. Optimal work-rest cycles for an isometric intermittent gripping task as a function of force, posture and grip span.

    Science.gov (United States)

    Eksioglu, Mahmut

    2006-02-10

    The aim of this study was to investigate the maximum acceptable contraction frequencies (i.e. work-rest cycles) for an isometric-intermittent handgrip task as a function of grip span, applied force and shoulder posture using psychophysical and physiological approaches. Twelve healthy males served as subjects. The three grip spans investigated were the optimal, 2 cm narrower than the optimal, and 2 cm wider than the optimal. The grip force levels studied were 15% and 30% of maximum voluntary grip force and the two shoulder postures were 25 degrees flexion and 30 degrees abduction. The psychophysical results indicate that subjects work faster with the narrower grip span at 15% of maximum voluntary grip force level in comparison to working with the optimal and the wider spans. However, when the task required 30% of maximum grip force level, the subjects worked faster with the optimal grip span. These findings were supported by the results of electromyography, heart rate, blood pressure and perceived discomfort. The study suggests that grip span of a tool is an important factor to be considered in predicting optimal work-rest cycles for hand grip tasks, and the optimum setting of grip span of the hand-tool depends on the required task force level. That is, the optimality is relative rather than absolute. In addition, it appears that weaker subjects can work at a higher rate than stronger ones at the same relative force level.

  17. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.

    Directory of Open Access Journals (Sweden)

    Devin Sok

    Full Text Available Broadly neutralizing HIV antibodies (bnAbs are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to model lineage evolution of the bnAbs PGT121-134 and found a positive correlation between the level of somatic hypermutation (SHM and the development of neutralization breadth and potency. Strikingly, putative intermediates were characterized that show approximately half the mutation level of PGT121-134 but were still capable of neutralizing roughly 40-80% of PGT121-134 sensitive viruses in a 74-virus panel at median titers between 15- and 3-fold higher than PGT121-134. Such antibodies with lower levels of SHM may be more amenable to elicitation through vaccination while still providing noteworthy coverage. Binding characterization indicated a preference of inferred intermediates for native Env binding over monomeric gp120, suggesting that the PGT121-134 lineage may have been selected for binding to native Env at some point during maturation. Analysis of glycan-dependent neutralization for inferred intermediates identified additional adjacent glycans that comprise the epitope and suggests changes in glycan dependency or recognition over the course of affinity maturation for this lineage. Finally, patterns of neutralization of inferred bnAb intermediates suggest hypotheses as to how SHM may lead to potent and broad HIV neutralization and provide important clues for immunogen design.

  18. Hand grip strength

    DEFF Research Database (Denmark)

    Frederiksen, Henrik; Gaist, David; Petersen, Hans Christian

    2002-01-01

    in life is a major problem in terms of prevalence, morbidity, functional limitations, and quality of life. It is therefore of interest to find a phenotype reflecting physical functioning which has a relatively high heritability and which can be measured in large samples. Hand grip strength is known......-55%). A powerful design to detect genes associated with a phenotype is obtained using the extreme discordant and concordant sib pairs, of whom 28 and 77 dizygotic twin pairs, respectively, were found in this study. Hence grip strength is a suitable phenotype for identifying genetic variants of importance to mid...

  19. The GRIP method for collaborative roadmapping workshops

    DEFF Research Database (Denmark)

    Piirainen, Kalle

    2015-01-01

    Technology roadmapping is a well-known tool for technology management, but practical advice for facilitating collaborative roadmapping workshops is relatively scarce. To cater for this need, we have designed a method for collaborative roadmapping, dubbed the GRIP method, for facilitating group work...

  20. Somatic populations of PGT135-137 HIV-1-neutralizing antibodies identified by 454 pyrosequencing and bioinformatics

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    Jiang eZhu

    2012-09-01

    Full Text Available Select HIV-1-infected individuals develop sera capable of neutralizing diverse viral strains. The molecular basis of this neutralization is currently being deciphered by the isolation of HIV-1-neutralizing antibodies. In one infected donor, three neutralizing antibodies, PGT135-137, were identified by assessment of neutralization from individually sorted B cells and found to recognize an epitope containing an N-linked glycan at residue 332 on HIV-1 gp120. Here we use deep sequencing and bioinformatics methods to interrogate the B cell record of this donor to gain a more complete understanding of the humoral immune response. PGT135-137-gene family-specific primers were used to amplify heavy and light chain-variable domain sequences. 454 pyrosequencing produced 141,298 heavy-chain sequences of IGHV4-39 origin and 87,229 light-chain sequences of IGKV3-15 origin. A number of heavy and light chain sequences of ~90% identity to PGT137, several to PGT136, and none of high identity to PGT135 were identified. After expansion of these sequences to include close phylogenetic relatives, a total of 202 heavy-chain sequences and 72 light-chain sequences were identified. These sequences were clustered into populations of 95% identity comprising 15 for heavy chain and 10 for light chain, and a select sequence from each population was synthesized and reconstituted with a PGT137-partner chain. Reconstituted antibodies showed varied neutralization phenotypes for HIV-1 clade A and D isolates. Sequence diversity of the antibody population represented by these tested sequences was notably higher than observed with a 454 pyrosequencing-control analysis on 10 antibodies of defined sequence, suggesting that this diversity results primarily from somatic maturation. Our results thus provide an example of how pathogens like HIV-1 are opposed by a varied humoral immune response, derived from intrinsic mechanisms of antibody development, and embodied by somatic populations

  1. Forearm posture and grip effects during push and pull tasks.

    Science.gov (United States)

    Di Domizio, Jennifer; Keir, Peter J

    2010-03-01

    Direction of loading and performance of multiple tasks have been shown to elevate muscle activity in the upper extremity. The purpose of this study was to evaluate the effects of gripping on muscle activity and applied force during pushing and pulling tasks with three forearm postures. Twelve volunteers performed five hand-based tasks in supinated, neutral and pronated forearm postures with the elbow at 90 degrees and upper arm vertical. All tasks were performed with the right (dominant) hand and included hand grip alone, push and pull with and without hand grip. Surface EMG from eight upper extremity muscles, hand grip force, tri-axial push and pull forces and wrist angles were recorded during the 10 s trials. The addition of a pull force to hand grip elevated activity in all forearm muscles (all p push with grip tasks, forearm extensor muscle activity tended to increase when compared with grip only while flexor activity tended to decrease. Forearm extensor muscle activity was higher with the forearm pronated compared with neutral and supinated postures during most isolated grip tasks and push or pull with grip tasks (all p push and pull forces could act to assist in creating grip force, forearm muscle activity generally decreased. These results provide strategies for reducing forearm muscle loading in the workplace. STATEMENT OF RELEVANCE: Tools and tasks designed to take advantage of coupling grip with push or pull actions may be beneficial in reducing stress and injury in the muscles of the forearm. These factors should be considered in assessing the workplace in terms of acute and cumulative loading.

  2. Normative data on functional grip strength of elderly in Singapore.

    Science.gov (United States)

    Mat Jais, Ita Suzana; Chan, Kai Li; Loke, Mun Kitt Austin; Abdul Rahim, Saleem; Tay, Shian Chao

    2017-02-21

    Cross-sectional study for clinical measurement. Most daily tasks require individuals to exert grip strength with torque, which can be challenging for elderly as their strength diminishes with age. We postulate that to assess the functional capacity of an individual, it is important to evaluate the functional grip strength instead of the maximal static grip strength. The objective of this cross-sectional study is to establish normative data for the functional grip strength of elderly aged 60 years and older in the Singapore population. In this study, 233 healthy subjects aged 60 years and older were recruited. Using a custom-made hand strength measurement device, the following measurements were recorded: grip strength at neutral position, grip strength with resistive pronation torque, and grip strength with resistive supination torque. Grip strengths measured for both genders decreased by 13% and 16% for males and females respectively, when pronation torque was exerted, and with supination torque, the strength decreased by 18% and 17% for males and females respectively. Normative data for the elderly population in Singapore had been established. The findings from this study can complement the existing ergonomic hand data in designing better assistive tools to improve the independent living of elderly. NA. Copyright © 2016 Hanley & Belfus. Published by Elsevier Inc. All rights reserved.

  3. Enter the Gripping Beast

    DEFF Research Database (Denmark)

    Sindbæk, Søren Michael

    2012-01-01

    of communities and their life world. Transcending technology, cultural dispositions and social relations, the study of innovations invites an actor-networks approach, which considers the heterogeneous nature of human-material relations. The archaeological record is potentially a rich source of evidence...... on innovations. Mostly, however, the time-resolution of archaeological data is too coarse-grained to allow us to grasp this potential to the full. In the period c. AD 790-850 a distinctly new artistic motif, the Gripping Beast, emerged in Scandinavia. A series of narrowly dated contexts provide anchor points...

  4. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Julien

    Full Text Available New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 family of antibodies, isolated from an African donor, neutralize ∼70% of circulating isolates with a median IC50 less than 0.05 µg ml(-1. Here, we show that three family members, PGT121, PGT122 and PGT123, have very similar crystal structures. A long 24-residue HCDR3 divides the antibody binding site into two functional surfaces, consisting of an open face, formed by the heavy chain CDRs, and an elongated face, formed by LCDR1, LCDR3 and the tip of the HCDR3. Alanine scanning mutagenesis of the antibody paratope reveals a crucial role in neutralization for residues on the elongated face, whereas the open face, which accommodates a complex biantennary glycan in the PGT121 structure, appears to play a more secondary role. Negative-stain EM reconstructions of an engineered recombinant Env gp140 trimer (SOSIP.664 reveal that PGT122 interacts with the gp120 outer domain at a more vertical angle with respect to the top surface of the spike than the previously characterized antibody PGT128, which is also dependent on the N332 glycan. We then used ITC and FACS to demonstrate that the PGT121 antibodies inhibit CD4 binding to gp120 despite the epitope being distal from the CD4 binding site. Together, these structural, functional and biophysical results suggest that the PGT121 antibodies may interfere with Env receptor engagement by an allosteric mechanism in which key structural elements, such as the V3 base, the N332 oligomannose glycan and surrounding glycans, including a putative V1/V2 complex biantennary glycan, are conformationally constrained.

  5. Finding Relief from Allergy's Grip

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Finding Relief from Allergy's Grip Past Issues / Summer 2006 Table ... action for patients who have had inadequate symptom relief with antihistamines and topical nasal steroids. Through injection ...

  6. Personalized Genetic Testing as a Tool for Integrating Ethics Instruction into Biology Courses

    Directory of Open Access Journals (Sweden)

    Tenny R. Zhang

    2014-09-01

    Full Text Available Personalized genetic testing (PGT has been used by some educational institutions as a pedagogical tool for teaching human genetics. While work has been done that examines the potential for PGT to improve students’ interest and understanding of the science involved in genetic testing, there has been less dialogue about how this method might be useful for integrating ethical and societal issues surrounding genetic testing into classroom discussions. Citing the importance of integrating ethics into the biology classroom, we argue that PGT can be an effective educational tool for integrating ethics and science education, and discuss relevant ethical considerations for instructors using this approach. 

  7. The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H

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    Rauna eRiva

    2015-02-01

    Full Text Available The virulence factor PgtE is an outer membrane protease (omptin of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough LPS, as observed e.g. in bacteria residing inside macrophages or just emerging from them. We investigated whether PgtE cleaves the complement factors B (B and H (H, key proteins controlling formation and inactivation of the complement protein C3b and thereby the activity of the complement system. S. enterica serovar Typhimurium or omptin-expressing recombinant E. coli bacteria were incubated with purified human complement proteins or recombinant H fragments. PgtE cleaved both B and H, whereas its close homolog Pla of Yersinia pestis cleaved only H. H was cleaved at both N- and C-termini, while the central region resisted proteolysis. Because of multiple effects of PgtE on complement components (cleavage of C3, C3b, B and H we assessed its effect on the opsonophagocytosis of Salmonella. In human serum, C3 cleavage was dependent on proteolytically active PgtE. Human neutrophils interacted less with serum-opsonized FITC-stained S. enterica 14028R than with the isogenic ΔpgtE strain, as analyzed by flow cytometry. In conclusion, cleavage of B and H by PgtE, together with C3 cleavage, affects the C3-mediated recognition of S. enterica by human neutrophils, thus thwarting the immune protection against Salmonella.

  8. Effect of object width on precision grip force and finger posture.

    Science.gov (United States)

    Domalain, M; Vigouroux, L; Danion, F; Sevrez, V; Berton, E

    2008-09-01

    This study aimed to define the effect of object width on spontaneous grasp. Participants held objects of various masses (0.75 to 2.25 kg) and widths (3.5 to 9.5 cm) between thumb and index finger. Grip force, maximal grip force and corresponding finger postures were recorded using an embedded force sensor and an optoelectronic system, respectively. Results showed that index finger joints varied to accommodate the object width, whereas thumb posture remained constant across conditions. For a given object mass, grip force increased as a function of object width, although this result is not dictated by the laws of mechanics. Because maximal grip force also increased with object width, we hypothesise that participants maintain a constant ratio between grip force and their maximal grip force at each given width. Altogether we conclude that when the task consists in manipulating objects/tools, the optimal width is different than when maximal force exertions are required.

  9. Pencil grips, legibility, and speed of fourth-graders' writing in cursive.

    Science.gov (United States)

    Koziatek, Susan M; Powell, Nancy J

    2003-01-01

    The purpose of this research was to study how the speed and legibility of fourth-graders handwriting was affected by type of pencil grip on the Evaluation Tool of Children's Handwriting-Cursive. Ninety-five typically developing students and 6 students receiving special education services completed the Evaluation Tool of Children's Handwriting-Cursive (ETCH-C). Photographs were taken of their pencil grips while they wrote the alphabet. One-way ANOVAs were calculated to compare legibility rates and writing speeds by type of pencil grip. Ninety-nine of the students used one of four pencil grips including the dynamic tripod (38 students), the dynamic quadrupod (18), the lateral tripod (22), and the lateral quadrupod (21). One student used the four-finger pencil grip and one used the interdigital pencil grip. Mean cursive writing speeds were similar for all pencil grips except for the interdigital grasp. Speeds obtained were slower than recently published fourth-grade speeds ranging from a mean of 29.45 to 34.75 letters per minute. CONCLUSION. This study found the lateral quadrupod and four-finger pencil grips to be as functional as the dynamic tripod, lateral tripod, and dynamic quadrupod pencil grips. This study provides average handwriting speeds for fourth-grade students on the ETCH-C.

  10. Gripped by movies: From story-world to artifact absorption

    NARCIS (Netherlands)

    Doicaru, M.M.

    2016-01-01

    That movies are a great source of entertainment seems to be common sense. But how exactly movies manage to get large audiences absorbed, or what is their gripping tool is still a mystery. Research makes use of different concepts pointing to narrative absorption, but it is not clear how they differ f

  11. The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H

    OpenAIRE

    Rauna eRiva; Korhonen, Timo K.; Seppo eMeri

    2015-01-01

    The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e., rough LPS, as observed e.g., in bacteria residing inside macrophages or just emerging from them. We investigated whether PgtE cleaves the complement factors B (B) and H (H), key proteins controlling formation and inactivation of the complement pro...

  12. Gripping System For Mechanical Testing Of Composites

    Science.gov (United States)

    Mackay, Rebecca A.; Nathal, Michael V.

    1994-01-01

    Specimens held without slippage, even at high temperatures. Improved gripping system designed to securely hold ends of specimen of composite material during creep or tensile test. Each grip includes pair of wedges having sharply corrugated gripping surfaces. Wedges held between two plates containing cavities sloped to accommodate wedges. Two such grips (one for each end) holds specimen in furnace connected to tensile test machine for creep measurements.

  13. Individual finger contribution in submaximal voluntary contraction of gripping.

    Science.gov (United States)

    Kong, Yong-Ku; Lee, Kyung-Sun; Kim, Dae-Min; Jung, Myung-Chul

    2011-11-01

    The objective of this study was to evaluate individual finger force and contribution to a gripping force, the difference between actual and expected finger forces and subjective discomfort rating at 10 different submaximal voluntary contraction (%MVC) levels (10-100% in 10 increments). Seventy-two participants randomly exerted gripping force with a multi-finger force measurement system. The individual finger force, gripping force and discomfort increased as %MVC levels increased. The middle and ring fingers exerted more force and contributed to a gripping force more than the index and little fingers due to their larger mass fractions of the digit flexor muscles. It was apparent at MVC; however, the index finger increased its contribution and exerted even more force than expected at more than 50% MVC. Subjective discomfort supported the results of the objective measures. This could explain the conflicting findings between index and ring fingers in previous finger contribution studies. STATEMENT OF RELEVANCE: Hand tool design is of special interest in ergonomics due to its association with musculoskeletal disorders in the hand. This study reveals a different contribution pattern of the fingers in submaximal voluntary contraction of gripping exertion.

  14. Improvement of handle grip using reverse engineering, CAE and Rapid Prototyping

    Directory of Open Access Journals (Sweden)

    Stoklasek Pavel

    2016-01-01

    Full Text Available The overwhelming majority of manual operations is even nowadays performed by using manual hand tools. These tools can be divided into 2 groups – hand tools designed for general use or a single-purpose hand tools for special operations. Tool described in this paper is used in assembling operation in the completion of electric motor. During the design of the existing tools the requirements for a functional part of the tool (lifespan, inability to damage the engine installation were fully considered, demands for ergonomic grip area, however, were not taken into account. Long-term use of incorrectly designed tool causes carpal tunnel syndrome, hand-arm vibration syndrome, diminished sensitivity or tingling in the fingers of workers. These difficulties can be reduced or entirely eliminated due to proper design of the grip of hand tool. Most authors focus on adjusting the grip for optimum ergonomics at individual types of grips (cylindrical, palmar, lateral, etc.. However, as already mentioned, there are tools for specific operations when the working area is limited by space or a specific type of load on the grip is needed. In some cases, it is often necessary to change the type of grip or combine different types of grips. This paper describes the design of an optimal grip of hand tool used for specific operation when assembling motors. Design of prototype mold and production of functional prototypes for ergonomics assessment directly in the workplace were realized. New design of handle should reduce the risk primarily of developing carpal tunnel in long-term use.

  15. Evaluation of pliers' grip spans in the maximum gripping task and sub-maximum cutting task.

    Science.gov (United States)

    Kim, Dae-Min; Kong, Yong-Ku

    2016-12-01

    A total of 25 males participated to investigate the effects of the grip spans of pliers on the total grip force, individual finger forces and muscle activities in the maximum gripping task and wire-cutting tasks. In the maximum gripping task, results showed that the 50-mm grip span had significantly higher total grip strength than the other grip spans. In the cutting task, the 50-mm grip span also showed significantly higher grip strength than the 65-mm and 80-mm grip spans, whereas the muscle activities showed a higher value at 80-mm grip span. The ratios of cutting force to maximum grip strength were also investigated. Ratios of 30.3%, 31.3% and 41.3% were obtained by grip spans of 50-mm, 65-mm, and 80-mm, respectively. Thus, the 50-mm grip span for pliers might be recommended to provide maximum exertion in gripping tasks, as well as lower maximum-cutting force ratios in the cutting tasks.

  16. Hydraulically Driven Grips For Hot Tensile Specimens

    Science.gov (United States)

    Bird, R. Keith; Johnson, George W.

    1994-01-01

    Pair of grips for tensile and compressive test specimens operate at temperatures up to 1,500 degrees F. Grips include wedges holding specimen inside furnace, where heated to uniform temperature. Hydraulic pistons drive wedges, causing them to exert clamping force. Hydraulic pistons and hydraulic fluid remain outside furnace, at room temperature. Cooling water flows through parts of grips to reduce heat transferred to external components. Advantages over older devices for gripping specimens in high-temperature tests; no need to drill holes in specimens, maintains constant gripping force on specimens, and heated to same temperature as that of specimen without risk of heating hydraulic fluid and acuator components.

  17. Motor cortical function and the precision grip.

    Science.gov (United States)

    Geevasinga, Nimeshan; Menon, Parvathi; Kiernan, Matthew C; Vucic, Steve

    2014-12-01

    While task-dependent changes in motor cortical outputs have been previously reported, the issue of whether such changes are specific for complex hand tasks remains unresolved. The aim of the present study was to determine whether cortical inhibitory tone and cortical output were greater during precision grip and power grip. Motor cortex excitability was undertaken by using the transcranial magnetic stimulation threshold tracking technique in 15 healthy subjects. The motor-evoked potential (MEP) responses were recorded over the abductor pollicis brevis (APB), with the hand in the following positions: (1) rest, (2) precision grip and (3) power grip. The MEP amplitude (MEP amplitude REST 23.6 ± 3.3%; MEP amplitude PRECISION GRIP 35.2 ± 5.6%; MEP amplitude POWER GRIP 19.6 ± 3.4%, F = 2.4, P < 0.001) and stimulus-response gradient (SLOPEREST 0.06 ± 0.01; SLOPEPRCISION GRIP 0.15 ± 0.04; SLOPE POWER GRIP 0.07 ± 0.01, P < 0.05) were significantly increased during precision grip. Short interval intracortical inhibition (SICI) was significantly reduced during the precision grip (SICI REST 15.0 ± 2.3%; SICI PRECISION GRIP 9.7 ± 1.5%, SICI POWER GRIP 15.9 ± 2.7%, F = 2.6, P < 0.05). The present study suggests that changes in motor cortex excitability are specific for precision grip, with functional coupling of descending corticospinal pathways controlling thumb and finger movements potentially forming the basis of these cortical changes.

  18. Evaluation of total grip strength and individual finger forces on opposing (A-type) handles among Koreans.

    Science.gov (United States)

    Kong, Yong-Ku; Seo, Min-Tae; Kang, Hyun-Sung

    2014-01-01

    The present study evaluated the effect of grip span on finger forces and defined the best grip span for maximising total grip strength based on the finger forces and subjective discomfort in a static exertion. Five grip spans (45, 50, 55, 60 and 65 mm) of the opposing (A-type) handle shape were tested in this study to measure total grip strength and individual finger force among Korean population. A total of 30 males who participated in this study were asked to exert a maximum grip force with two repetitions, and to report the subjective discomfort experienced between exertions using the Borg's CR-10 scale. The highest grip strength was obtained at 45 mm and 50 mm grip spans. Results also showed that forces of all fingers, except for the middle finger force, significantly differed over the grip spans. The lowest subjective discomfort was observed in the 50 mm grip span. The results might be used as development guidelines for ergonomic opposing (A-type) hand tools for Korean population.

  19. Examinations of factors influencing toe grip strength.

    Science.gov (United States)

    Soma, Masayuki; Murata, Shin; Kai, Yoshihiro; Nakae, Hideyuki; Satou, Yousuke; Murata, Jun; Miyazaki, Junya

    2016-11-01

    [Purpose] This study examined the relationship between toe grip strength and its associated factors by focusing on factors that were suggested to have a relationship with toe grip strength in previous studies, aiming to clarify the factors influencing the toe grip strength of healthy women. [Subjects and Methods] Twelve healthy young women were selected for this study. Their toe grip strength, angular changes in their ankle joint during toe grip, maximum voluntary contraction activities of the rectus femoris, biceps femoris, and tibialis anterior muscles, and the medial head of the gastrocnemius muscles were measured using electromyography. Their toe curl ability, foot-arch height ratio, and weight were also measured. [Results] Multiple regression analysis demonstrated that the predictors of toe grip strength in the resulting model were foot-arch height ratio and the percentage of integrated electromyography (%IEMG) of the tibialis anterior muscle, as the dependent variables. This reveals that women whose tibialis anterior muscle %IEMG values and foot-arch height ratio are high have greater %IEMG values have greater toe grip strength. [Conclusion] These findings suggest a significant relationship between foot-arch height ratio and toe grip strength, with a reciprocal interaction. These findings further indicate that the risk of falls by the elderly could be decreased if toe grip strength were enhanced, by increasing the height of a low foot-arch with the help of an inserted insole.

  20. Hand-grip strength cut points to screen older persons at risk for mobility limitation.

    Science.gov (United States)

    Sallinen, Janne; Stenholm, Sari; Rantanen, Taina; Heliövaara, Markku; Sainio, Päivi; Koskinen, Seppo

    2010-09-01

    To determine optimal hand-grip strength cut points for likelihood of mobility limitation in older people and to study whether these cut points differ according to body mass index (BMI). Cross-sectional analysis of data. Data collected in the Finnish population-based Health 2000 Survey. One thousand eighty-four men and 1,562 women aged 55 and older with complete data on anthropometry, hand-grip strength and self-reported mobility. Mobility limitation was defined as difficulty walking 0.5 km or climbing stairs. Receiver operating characteristic analysis was used to estimate hand-grip strength cut points for likelihood of mobility limitation. The overall hand-grip strength cut points for likelihood of mobility limitation were 37 kg (sensitivity 62%; specificity 76%) for men and 21 kg (sensitivity 67%; specificity 73%) for women. The effect of the interaction between hand-grip strength and BMI on mobility limitation was significant in men (P=.02), but no such interaction was observed in women (P=.16). In men, the most-optimal cutoff points were 33 kg (sensitivity 73%; specificity 79%) for normal-weight men, 39 kg (sensitivity 67%; specificity 71%) for overweight men, and 40 kg (sensitivity 57%; specificity 68%) for obese men. In women, BMI-specific hand-grip strength cutoff values was not markedly more accurate than the overall cutoff value. The hand-grip strength test is a useful tool to identify persons at risk of mobility limitation. In men, hand-grip strength cut points for mobility increased with BMI, whereas in women, only one hand-grip strength threshold was identified. © 2010, Copyright the Authors. Journal compilation © 2010, The American Geriatrics Society.

  1. Estimating thumb-index finger precision grip and manipulation potential in extant and fossil primates.

    Science.gov (United States)

    Feix, Thomas; Kivell, Tracy L; Pouydebat, Emmanuelle; Dollar, Aaron M

    2015-05-06

    Primates, and particularly humans, are characterized by superior manual dexterity compared with other mammals. However, drawing the biomechanical link between hand morphology/behaviour and functional capabilities in non-human primates and fossil taxa has been challenging. We present a kinematic model of thumb-index precision grip and manipulative movement based on bony hand morphology in a broad sample of extant primates and fossil hominins. The model reveals that both joint mobility and digit proportions (scaled to hand size) are critical for determining precision grip and manipulation potential, but that having either a long thumb or great joint mobility alone does not necessarily yield high precision manipulation. The results suggest even the oldest available fossil hominins may have shared comparable precision grip manipulation with modern humans. In particular, the predicted human-like precision manipulation of Australopithecus afarensis, approximately one million years before the first stone tools, supports controversial archaeological evidence of tool-use in this taxon.

  2. Hand-grip isometric strength in judo

    Directory of Open Access Journals (Sweden)

    Juan G Bonitch-Góngora

    2014-02-01

    Full Text Available The grip is an important technical and tactical aspect through which the judokas dominate the adversary, hindering the application of appropriate techniques and favoring their own attack. The judokas must have high levels of isometric force and endurance to this type of force on the gripping muscles of the forearms, as one of the key aspects for success. This article reviews the grip muscular strength and endurance profiles of judokas of different groups (gender, age and competitive level. In general, the peak isometric strength of elite judokas has not changed in the last 40 years and is similar to that reached by non-elite judokas or even registered in large populations. This indicate that the evaluation of the isometric hand grip endurance may be a more relevant parameter than the peak isometric force in judokas, as during the bouts the grip must be maintained for relatively long periods of time and the maximum force cannot be maintained for long. However there are few studies on the ability to resist successive isometric handgrip stress in judokas.

  3. [Grip strength changes in familial amyloidotic polyneuropathy].

    Science.gov (United States)

    Tomás, Maria Teresa; Santa-Clara, Helena; Monteiro, Estela; Carolino, Elizabete; Freire, António; Barroso, Eduardo

    2010-01-01

    Familial amiloidotic polyneuropathy (FAP) is an autossomical and dominant neurodegenerative disease related with systemic deposition of amyloid fibre mainly on peripheral nervous system. Clinically, is translated by an autonomous sensitive-motor polyneuropathy with beginning nearly always in foot, involving subsequently the hands. Until now, the unique available treatment for FAP disease is liver transplantation requiring medication that negatively affect muscle metabolism and force production mechanism. To our knowledge there are no quantitative characterizations of peak force in FAP patients or any comparison with healthy people. This knowledge will be extremely important to verify clinical and functional evolution of this disease and eventually prescribe an effective rehabilitation program. The purpose of this study was to analyse and compare levels of hand grip strength (peak force and endurance) in FAP patients with (FAPTx) or without (FAPNTx) a liver transplant with a group of healthy people (GC). The total sample of individuals where two hundred and six, assigned in 3 groups: 59 patients PAFNTx (23 males, 36 female; age 35 ± 8 years); 90 patients PAFTx (53 males, 37 females; age 34 ± 8 years) e 62 healthy persons (GC) (30 males, 32 females; age 33 ± 9 years). Grip strength was assessed by a portable grip dynamometer E-link (Biometrics Ltd, UK). All measurements were taken on standardized positions with standardized orders. The value noted to peak force was classified according to American College of Sports Medicine norms for grip strength. The 3 groups are differents (p < 0,05) for weigth, body mass index (BMI) and grip strength in both hands and endurance for left hand. Negative correlations between age and grip strength were found for PAFNTx and PAFTx but not for GC. According to our results FAP patients have lower values for grip strength in both hands than healthy subjects and consequently a worse classification in ACSM norms. Most patients present

  4. Temperature limit values for gripping cold surfaces

    NARCIS (Netherlands)

    Malchaire, J.; Geng, Q.; Den Hartog, E.; Havenith, G.; Holmer, I.; Piette, A.; Powell, S.L.; Rintamäki, H.; Rissanen, S.

    2002-01-01

    Objectives. At the request of the European Commission and in the framework of the European Machinery Directive, research was conducted jointly in five different laboratories to develop specifications for surface temperature limit values for the gripping and handling of cold items. Methods. Four

  5. Temperature limit values for gripping cold surfaces

    NARCIS (Netherlands)

    Malchaire, J.; Geng, Q.; Den Hartog, E.; Havenith, G.; Holmer, I.; Piette, A.; Powell, S.L.; Rintamäki, H.; Rissanen, S.

    2002-01-01

    Objectives. At the request of the European Commission and in the framework of the European Machinery Directive, research was conducted jointly in five different laboratories to develop specifications for surface temperature limit values for the gripping and handling of cold items. Methods. Four hund

  6. Grip-Pattern Recognition for Smart Guns

    NARCIS (Netherlands)

    Kauffman, J.A.; Bazen, A.M.; Gerez, S.H.; Veldhuis, R.N.J.

    2003-01-01

    This paper describes the design, implementation and evaluation of a user-verification system for a smart gun, which is based on grip-pattern recognition. An existing pressure sensor consisting of an array of 44 x 44 piezoresistive elements has been used. An interface has been developed to acquire pr

  7. ANALYSIS OF POWER GRIP AND PINCH GRIP AMONG HEALTH CARE PROFESSIONALS

    Directory of Open Access Journals (Sweden)

    Zakariya M P

    2016-02-01

    Full Text Available Background: Grip and pinch strength are commonly employed indices of strength used in hand evaluations. Pinch grip and power grip strengths are used as indices of strength in hand therapy assessments. For all professions grip strength is an important criterion to be successful in their profession. Such phenomena may be explained by differences in nature of work, working environment, and objects workers handle. Method: 200 healthy subjects, satisfying the selection criteria were included and assessed with standardized procedure for power grip and pinch grip (lateral pinch, pad-pad, and tip-tip strength. They were divided in four groups, 50 group each according to profession i.e. medical surgeons, dentist, physiotherapists and nurses. Results: The mean power grip strength shows highly significant difference between medical vs. dental (p>0.01 and medical vs. physiotherapy group (p> 0.05 .The mean lateral pinch strength shows there is highly significant difference (p< 0.001 between dental vs. nursing profession and dental vs. physiotherapy group. No significant difference among other groups. The mean pad-pad pinch strength shows there is significant difference between dental vs. nursing (p< 0.05 and dental vs physiotherapy group (p< 0.05. The mean Tip-Tip pinch strength shows there is significant difference between dental vs nursing profession(p< 0.05 and dental vs. physiotherapy(p< 0.05. No significant different among other groups. Conclusion: Surgeons have highest power grip strength followed by Nursing, Physiotherapy and Dental professionals. Dentists have the maximum pinch strength in all three positions, followed by Surgeons, Nurses and Physiotherapists. Surgeons have maximum pinch strength next to Dentists.

  8. Registration of hand-grip pattern in smart gun

    NARCIS (Netherlands)

    Shang, X.; Veldhuis, R.N.J.

    2006-01-01

    Secure Grip1 focuses on the development of a hand-grip pattern recognition system, as part of a smart gun. It is intended for use by the police. We collected the hand-grip data from police officers in three sessions in a row with time intervals in between. If data for training and testing come from

  9. Variability of grip kinetics during adult signature writing.

    Directory of Open Access Journals (Sweden)

    Bassma Ghali

    Full Text Available Grip kinetics and their variation are emerging as important considerations in the clinical assessment of handwriting pathologies, fine motor rehabilitation, biometrics, forensics and ergonomic pen design. This study evaluated the intra- and inter-participant variability of grip shape kinetics in adults during signature writing. Twenty (20 adult participants wrote on a digitizing tablet using an instrumented pen that measured the forces exerted on its barrel. Signature samples were collected over 10 days, 3 times a day, to capture temporal variations in grip shape kinetics. A kinetic topography (i.e., grip shape image was derived per signature by time-averaging the measured force at each of 32 locations around the pen barrel. The normalized cross correlations (NCC of grip shape images were calculated within- and between-participants. Several classification algorithms were implemented to gauge the error rate of participant discrimination based on grip shape kinetics. Four different grip shapes emerged and several participants made grip adjustments (change in grip shape or grip height or rotated the pen during writing. Nonetheless, intra-participant variation in grip kinetics was generally much smaller than inter-participant force variations. Using the entire grip shape images as a 32-dimensional input feature vector, a K-nearest neighbor classifier achieved an error rate of 1.2±0.4% in discriminating among participants. These results indicate that writers had unique grip shape kinetics that were repeatable over time but distinct from those of other participants. The topographic analysis of grip kinetics may inform the development of personalized interventions or customizable grips in clinical and industrial applications, respectively.

  10. Variability of grip kinetics during adult signature writing.

    Science.gov (United States)

    Ghali, Bassma; Thalanki Anantha, Nayanashri; Chan, Jennifer; Chau, Tom

    2013-01-01

    Grip kinetics and their variation are emerging as important considerations in the clinical assessment of handwriting pathologies, fine motor rehabilitation, biometrics, forensics and ergonomic pen design. This study evaluated the intra- and inter-participant variability of grip shape kinetics in adults during signature writing. Twenty (20) adult participants wrote on a digitizing tablet using an instrumented pen that measured the forces exerted on its barrel. Signature samples were collected over 10 days, 3 times a day, to capture temporal variations in grip shape kinetics. A kinetic topography (i.e., grip shape image) was derived per signature by time-averaging the measured force at each of 32 locations around the pen barrel. The normalized cross correlations (NCC) of grip shape images were calculated within- and between-participants. Several classification algorithms were implemented to gauge the error rate of participant discrimination based on grip shape kinetics. Four different grip shapes emerged and several participants made grip adjustments (change in grip shape or grip height) or rotated the pen during writing. Nonetheless, intra-participant variation in grip kinetics was generally much smaller than inter-participant force variations. Using the entire grip shape images as a 32-dimensional input feature vector, a K-nearest neighbor classifier achieved an error rate of 1.2±0.4% in discriminating among participants. These results indicate that writers had unique grip shape kinetics that were repeatable over time but distinct from those of other participants. The topographic analysis of grip kinetics may inform the development of personalized interventions or customizable grips in clinical and industrial applications, respectively.

  11. ASSESSMENT OF GRIP FORCE CONTROL IN PATIENTS WITH MUSCULAR DYSTROPHY

    Directory of Open Access Journals (Sweden)

    Gregorij Kurillo

    2004-12-01

    Full Text Available Background. The majority of hand functionality tests are based on qualitative assessment which largely depends on the experience of the therapist. Computer-assisted methods can provide more objective and accurate measurements of the grip force and other parameters related to grasping.Methods. We analysed the grip force control in 12 patients with muscular dystrophy using the tracking system developed. The system consists of a grip-measuring device with endobjects assessing the force applied in different grips. The device was used as input to a tracking task where the patient applied the grip force according to the visual feedback from the computer screen. Each patient performed two tasks which consisted of tracking a ramp and sinus target.Results. We analysed the maximal grip force as assessed in the ramp task and the tracking accuracy of the sinus task. The results are compared among five different grips (cylindrical, lateral, palmar, pinch and spherical grip, applied with dominant and non-dominant hand. The results show no significant difference in tracking accuracy between the dominant and non-dominant hand.Conclusions. The results obtained in tracking the ramp target showed that the method could be used for the assessment of the muscle fatigue, providing quantitative information on muscle capacity. The results of the sinus-tracking task showed that the method can evaluate the grip force control in different types of grips, providing information on hand dexterity, muscle activation patterns or tremor.

  12. Proximal arm kinematics affect grip force-load force coordination

    OpenAIRE

    Vermillion, Billy C.; Lum, Peter S; Lee, Sang Wook

    2015-01-01

    During object manipulation, grip force is coordinated with load force, which is primarily determined by object kinematics. Proximal arm kinematics may affect grip force control, as proximal segment motion could affect control of distal hand muscles via biomechanical and/or neural pathways. The aim of this study was to investigate the impact of proximal kinematics on grip force modulation during object manipulation. Fifteen subjects performed three vertical lifting tasks that involved distinct...

  13. Microspine Gripping Mechanism for Asteroid Capture

    Science.gov (United States)

    Merriam, Ezekiel G.; Berg, Andrew B.; Willig, Andrew; Parness, Aaron; Frey, Tim; Howell, Larry L.

    2016-01-01

    This paper details the development and early testing of a compliant suspension for a microspine gripper device for asteroid capture or micro-gravity percussive drilling. The microspine gripper architecture is reviewed, and a proposed microspine suspension design is presented and discussed. Prototyping methods are discussed, as well as testing methods and results. A path forward is identified from the results of the testing completed thus far. Key findings include: the microspine concept has been established as a valid architecture and the compliant suspension exhibits the desired stiffness characteristics for good gripping behavior. These developments will aid in developing the capability to grasp irregularly shaped boulders in micro-gravity.

  14. Analysis list: Grip1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Grip1 Blood + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Grip1.1.tsv... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Grip1.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Gri...p1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Grip1.Blood.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Blood.gml ...

  15. Adaptive Human Control Gains During Precision Grip

    Directory of Open Access Journals (Sweden)

    Erik D. Engeberg

    2013-03-01

    Full Text Available Eight human test subjects attempted to track a desired position trajectory with an instrumented manipulandum (MN. The test subjects used the MN with three different levels of stiffness. A transfer function was developed to represent the human application of a precision grip from the data when the test subjects initially displaced the MN so as to learn the position mapping from the MN onto the display. Another transfer function was formed from the data of the remainder of the experiments, after significant displacement of the MN occurred. Both of these transfer functions accurately modelled the system dynamics for a portion of the experiments, but neither was accurate for the duration of the experiments because the human grip dynamics changed while learning the position mapping. Thus, an adaptive system model was developed to describe the learning process of the human test subjects as they displaced the MN in order to gain knowledge of the position mapping. The adaptive system model was subsequently validated following comparison with the human test subject data. An examination of the average absolute error between the position predicted by the adaptive model and the actual experimental data yielded an overall average error of 0.34mm for all three levels of stiffness.

  16. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.

    Science.gov (United States)

    Kong, Leopold; Torrents de la Peña, Alba; Deller, Marc C; Garces, Fernando; Sliepen, Kwinten; Hua, Yuanzi; Stanfield, Robyn L; Sanders, Rogier W; Wilson, Ian A

    2015-10-01

    The HIV-1 envelope gp160 glycoprotein (Env) is a trimer of gp120 and gp41 heterodimers that mediates cell entry and is the primary target of the humoral immune response. Broadly neutralizing antibodies (bNAbs) to HIV-1 have revealed multiple epitopes or sites of vulnerability, but mapping of most of these sites is incomplete owing to a paucity of structural information on the full epitope in the context of the Env trimer. Here, a crystal structure of the soluble BG505 SOSIP gp140 trimer at 4.6 Å resolution with the bNAbs 8ANC195 and PGT128 reveals additional interactions in comparison to previous antibody-gp120 structures. For 8ANC195, in addition to previously documented interactions with gp120, a substantial interface with gp41 is now elucidated that includes extensive interactions with the N637 glycan. Surprisingly, removal of the N637 glycan did not impact 8ANC195 affinity, suggesting that the antibody has evolved to accommodate this glycan without loss of binding energy. PGT128 indirectly affects the N262 glycan by a domino effect, in which PGT128 binds to the N301 glycan, which in turn interacts with and repositions the N262 glycan, thereby illustrating the important role of neighboring glycans on epitope conformation and stability. Comparisons with other Env trimer and gp120 structures support an induced conformation for glycan N262, suggesting that the glycan shield is allosterically modified upon PGT128 binding. These complete epitopes of two broadly neutralizing antibodies on the Env trimer can now be exploited for HIV-1 vaccine design.

  17. Algorithm design for grip-pattern verification in smart gun

    NARCIS (Netherlands)

    Shang, X.; Veldhuis, R.N.J.; Bazen, A.M.; Ganzevoort, W.P.T.

    2005-01-01

    The Secure Grip project1 focuses on the development of a hand-grip pattern recognition system, as part of the smart gun. Its target customer is the police. To explore the authentication performance of this system, we collected data from a group of police officers, and made authentication simulations

  18. Biometric verification based on grip-pattern recognition

    NARCIS (Netherlands)

    Veldhuis, Raymond; Bazen, Asker; Kauffman, Joost; Hartel, Pieter

    2004-01-01

    This paper describes the design, implementation and evaluation of a user-verification system for a smart gun, which is based on grip-pattern recognition. An existing pressure sensor consisting of an array of 44 £ 44 piezoresistive elements is used to measure the grip pattern. An interface has been d

  19. Biometric verification based on grip-pattern recognition

    NARCIS (Netherlands)

    Veldhuis, Raymond N.J.; Bazen, A.M.; Kauffman, J.A.; Hartel, Pieter H.; Delp, Edward J.; Wong, Ping W.

    This paper describes the design, implementation and evaluation of a user-verification system for a smart gun, which is based on grip-pattern recognition. An existing pressure sensor consisting of an array of 44 x 44 piezoresistive elements is used to measure the grip pattern. An interface has been

  20. Algorithm Design for Grip-Pattern Verification in Smart Gun

    NARCIS (Netherlands)

    Shang, X.; Veldhuis, Raymond N.J.; Bazen, A.M.; Ganzevoort, W.P.T.

    2005-01-01

    The Secure Grip project1 focuses on the development of a hand-grip pattern recognition system, as part of the smart gun. Its target customer is the police. To explore the authentication performance of this system, we collected data from a group of police officers, and made authentication simulations

  1. Grip-pattern recognition: Applied to a smart gun

    NARCIS (Netherlands)

    Shang, X.

    2008-01-01

    In our work the verification performance of a biometric recognition system based on grip patterns, as part of a smart gun for use by the police ocers, has been investigated. The biometric features are extracted from a two-dimensional pattern of the pressure, exerted on the grip of a gun by the hand

  2. Grip-pattern verification for a smart gun

    NARCIS (Netherlands)

    Shang, X.; Groenland, J.P.J.; Groenland, J.P.J.; Veldhuis, Raymond N.J.

    In the biometric verification system of a smart gun, the rightful user of the gun is recognized based on grip-pattern recognition. It was found that the verification performance of grip-pattern recognition degrades strongly when the data for training and testing the classifier, respectively, have

  3. Study on the collision-mechanical properties of tomatoes gripped by ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-12-15

    Dec 15, 2009 ... The data of collision-mechanical property of tomatoes gripped by robot fingers are important for the gripping control of .... Figure 2a shows the process of robot fingers gripping tomato. ..... Drop test simulation of a sample.

  4. Improved Friction Joint With Self-Locking Grips

    DEFF Research Database (Denmark)

    Costache, Andrei; Glejbøl, Kristian; Sivebæk, Ion Marius

    2016-01-01

    Flexible risers are used in the oil industry to transport liquids and gas from the seafloorto extraction and production equipment at the sea surface. Ongoing research aims at using composite materials instead of steel, in order to reduce weight and increase stiffness. Ensuring an optimal load...... transfer between the composite and metal components is very important. This paper presents an improved method for anchoring a flat fiber reinforced tendon using a double grip system with self-locking grips. The novelty is the combination of new experimental results and finite element (FE) analysis...... to develop asuperior dry friction grip. Experimental results are carried using a dedicated test setup, through which the test parameters can be accurately controlled. The efficiency of the grip system during pullout is superior to results obtained with flat grips. Numerical results offer an in...

  5. A simple technique to study embodied language processes: the grip force sensor.

    Science.gov (United States)

    Nazir, Tatjana A; Hrycyk, Lianna; Moreau, Quentin; Frak, Victor; Cheylus, Anne; Ott, Laurent; Lindemann, Oliver; Fischer, Martin H; Paulignan, Yves; Delevoye-Turrell, Yvonne

    2017-02-01

    Research in cognitive neuroscience has shown that brain structures serving perceptual, emotional, and motor processes are also recruited during the understanding of language when it refers to emotion, perception, and action. However, the exact linguistic and extralinguistic conditions under which such language-induced activity in modality-specific cortex is triggered are not yet well understood. The purpose of this study is to introduce a simple experimental technique that allows for the online measure of language-induced activity in motor structures of the brain. This technique consists in the use of a grip force sensor that captures subtle grip force variations while participants listen to words and sentences. Since grip force reflects activity in motor brain structures, the continuous monitoring of force fluctuations provides a fine-grained estimation of motor activity across time. In other terms, this method allows for both localization of the source of language-induced activity to motor brain structures and high temporal resolution of the recorded data. To facilitate comparison of the data to be collected with this tool, we present two experiments that describe in detail the technical setup, the nature of the recorded data, and the analyses (including justification about the data filtering and artifact rejection) that we applied. We also discuss how the tool could be used in other domains of behavioral research.

  6. Freezing grip - new application of the Peltier technology; Gefriergreifer - neue Anwendung der Peltier-Technik

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, L.; Stephan, J. [NAISS GmbH, Berlin (Germany)

    2002-12-01

    The rising requirements in efficiency and quality lead to products of in addition integration and functionality with ever smaller components. In addition new materials with improved characteristics are used e.g. GRP components plastics. Due to the characteristics of miniature units and new materials an automated assembling process becomes ever more difficult. With CRYO grip gripping tools were developed, which transport material units and carefully. (orig.) [German] Die steigenden Anforderungen an Leistungsfaehigkeit und Qualitaet fuehren zu Produkten hoeherer Integration und Funktionalitaet mit immer kleineren Komponenten. Ausserdem kommt es zur Anwendung neuer Werkstoffe mit verbesserten Eigenschaften wie z. B. Faserverbundkunststoffen. Aufgrund der Eigenschaften von Miniaturbauteilen und neuer Materialien wird ein automatisierter Montageprozess immer schwieriger. Mit CRYO-Greifern sind Greifwerkzeuge entwickelt worden, die materialschonend und sicher solche Bauteile transportieren. (orig.)

  7. Coefficient of variation in maximal and feigned static and dynamic grip efforts.

    Science.gov (United States)

    Dvir, Z

    1999-01-01

    The purpose of this study was to investigate the validity of the coefficient of variation as an identifier of feigned grip effort. Seventeen healthy female aged 20 to 25 yr participated in the study. Maximal and feigned efforts were measured isometrically and isokinetically (concentric and eccentric) using the Jamar and KinCom dynamometers, respectively. Findings indicated that, in all situations, the coefficient of variation derived from the maximal effort was significantly (P < 0.0001) lower than that derived from the feigned effort. However, the extent of overlapping between the two was sufficiently large to render the test sensitivities very low. Consequently, regardless of the measurement method, the coefficient of variation is not a valid tool for identifying feigned grip effort in healthy subjects.

  8. JPL Genesis and Rapid Intensification Processes (GRIP) Portal

    Science.gov (United States)

    Knosp, Brian W.; Li, P. Peggy; Vu, Quoc A.; Turk, Francis J.; Shen, Tsae-Pyng J.; Hristova-Veleva, Svetla M.; Licata, Stephen J.; Poulsen, William L.

    2012-01-01

    Satellite observations can play a very important role in airborne field campaigns, since they provide a comprehensive description of the environment that is essential for the experiment design, flight planning, and post-experiment scientific data analysis. In the past, it has been difficult to fully utilize data from multiple NASA satellites due to the large data volume, the complexity of accessing NASA s data in near-real-time (NRT), as well as the lack of software tools to interact with multi-sensor information. The JPL GRIP Portal is a Web portal that serves a comprehensive set of NRT observation data sets from NASA and NOAA satellites describing the atmospheric and oceanic environments related to the genesis and intensification of the tropical storms in the North Atlantic Ocean. Together with the model forecast data from four major global atmospheric models, this portal provides a useful tool for the scientists and forecasters in planning and monitoring the NASA GRIP field campaign during the 2010 Atlantic Ocean hurricane season. This portal uses the Google Earth plug-in to visualize various types of data sets, such as 2D maps, wind vectors, streamlines, 3D data sets presented at series of vertical cross-sections or pointwise vertical profiles, and hurricane best tracks and forecast tracks. Additionally, it allows users to overlap multiple data sets, change the opacity of each image layer, generate animations on the fly with selected data sets, and compare the observation data with the model forecast using two independent calendars. The portal also provides the capability to identify the geographic location of any point of interest. In addition to supporting the airborne mission planning, the NRT data and portal will serve as a very rich source of information during the post-field campaign analysis stage of the airborne experiment. By including a diverse set of satellite observations and model forecasts, it provides a good spatial and temporal context for the

  9. Proximal arm kinematics affect grip force-load force coordination.

    Science.gov (United States)

    Vermillion, Billy C; Lum, Peter S; Lee, Sang Wook

    2015-10-01

    During object manipulation, grip force is coordinated with load force, which is primarily determined by object kinematics. Proximal arm kinematics may affect grip force control, as proximal segment motion could affect control of distal hand muscles via biomechanical and/or neural pathways. The aim of this study was to investigate the impact of proximal kinematics on grip force modulation during object manipulation. Fifteen subjects performed three vertical lifting tasks that involved distinct proximal kinematics (elbow/shoulder), but resulted in similar end-point (hand) trajectories. While temporal coordination of grip and load forces remained similar across the tasks, proximal kinematics significantly affected the grip force-to-load force ratio (P = 0.042), intrinsic finger muscle activation (P = 0.045), and flexor-extensor ratio (P muscles and the elbow joint cannot fully explain the observed changes, as task-related changes in intrinsic hand muscle activation were greater than in extrinsic hand muscles. Rather, between-task variation in grip force (highest during task 3) appears to contrast to that in shoulder joint velocity/acceleration (lowest during task 3). These results suggest that complex neural coupling between the distal and proximal upper extremity musculature may affect grip force control during movements, also indicated by task-related changes in intermuscular coherence of muscle pairs, including intrinsic finger muscles. Furthermore, examination of the fingertip force showed that the human motor system may attempt to reduce variability in task-relevant motor output (grip force-to-load force ratio), while allowing larger fluctuations in output less relevant to task goal (shear force-to-grip force ratio).

  10. Anticipatory grip force between 1 and 3g

    Science.gov (United States)

    White, Olivier; Van Loon, ing.. Jack J. W. A.; Thonnard, Jean-Louis; Hermsdorfer, Joachim; Lefevre, Philippe

    One remarkable capacity of utilizing common tools appropriately as soon as we grasp them relies on the ability to determine in advance the grip force (GF) required to handle them in relation to their mechanical properties and the surrounding environment. This anticipatory strategy avoids the uncompressible delays in the feedback system. The predictive control of GF is made possible because the nervous system can learn, store and then select the internal representations of the dynamics of innumerable objects, known as internal models. Beside this flexibility, the nervous system's ability to learn different task dynamics is often limited in classical robotic experiments The environment itself can be profoundly modified in altered gravity or centrifugation. The few studies that investigated motor adaptation in such contexts did not consider the interaction between gravitational phases and even less the transitions across environments. Here, we tested subject's abilities to adapt to levels of gravitational fields generated by a human centrifuge. In Experiment 1, seven subjects performed 4 lifting trials in each gravitational phase (1 to 2.5g and then 2.5 to 1g by steps of 0.5g) with a 0.12 kg instrumented object. In Experiment 2, six subjects performed vertical oscillations of the object during transitions between 1 and 3g (0.5g steps, ascending and descending phases, profile repeated twice). We continuously measured GF, load force (LF) and ambient gravity. We hypothesized that participants were able to predictively adjust GF to the new environment. In Experiment 1, participants adjusted their GF proportionally to gravity and decreased GF across trials within a given gravitational environment. Preload phases decreased over time from 300ms to 50ms irrespective of gravity. We quantified the abilities of participants to switch across environments by subtracting GF recorded in the last trial in the current gravity level from GF during the first trial in the new environment

  11. Effect of paddle grip on segmental fluid distribution in elite slalom paddlers.

    Science.gov (United States)

    Bílý, Milan; Baláš, Jiří; Martin, Andrew John; Cochrane, Darryl; Coufalová, Klára; Süss, Vladimír

    2013-01-01

    Issues of high levels of muscular asymmetry have been associated with injury risk, and therefore have potential implications for decremental performance at the elite sport level. The aim of this current study was to assess the relationship between the segmental fluid distribution and the paddle grip in elite male and female slalom kayakers and canoeists. Eighty-four world-cup competitors (61 males and 23 females) took part in the study. Impedance analysis was used to assess segmental fluid asymmetry. The effect of paddle grip (loose/fixed hand in kayakers, lower/upper hand in canoeists), morphological dominance (dominant/non-dominant) and discipline (canoe/kayak) were evaluated by repeated measures ANOVA. The findings indicated a significant effect of paddle grip in canoeists on morphological asymmetry in upper limbs (arm of lower paddle hand mean fluid distribution 3.28, s=0.43 litres; arm of upper paddle hand mean fluid distribution 3.19, s=0.41 litres; P=0.000, [Formula: see text]=0.33). The sternmen demonstrated higher asymmetry between the arms of upper and lower paddle hand (mean 0.11, s=0.04 litres, P=0.000, [Formula: see text]=0.80) than the bowmen (mean 0.04, s=0.06 litres, P=0.015, [Formula: see text]=0.44) in double-canoes. Significant morphological asymmetry was found also in kayakers but the effect of paddle grip was not substantial. The use of segmental impedance analysis may be a suitable diagnostic tool for assessing morphological changes, which can be related to paddling training. Likewise muscular asymmetry is associated with injury risk; the evaluation of morphological changes during the training process may be considered by sport trainers and physical therapists.

  12. Effect of syllable articulation on precision and power grip performance.

    Directory of Open Access Journals (Sweden)

    Lari Vainio

    Full Text Available The present study was motivated by a theory, which proposes that speech includes articulatory gestures that are connected to particular hand actions. We hypothesized that certain articulatory gestures would be more associated with the precision grip than with the power grip, and vice versa. In the study, the participants pronounced a syllable and performed simultaneously a precision or power grip that was theorized to be either congruent or incongruent with the syllable. Relatively fast precision grip responses were associated with articulatory gestures in which the tip of the tongue contacted the alveolar ridge ([te] or the aperture of the vocal tract remained small ([hi], as well as gestures that required lip protrusion ([pu]. In contrast, relatively fast power grip responses were associated with gestures that were produced by moving the back of the tongue against the velum ([ke] or in which the aperture of the vocal tract remained large ([hα]. In addition to demonstrating that certain articulatory gestures are systematically connected to different grip types, the study may shed some light on discussion concerning sound symbolism and evolution of speech.

  13. Grip op werkstress. Mindfulness ontstresst maatschappelijk werkers

    Directory of Open Access Journals (Sweden)

    Jen van Horen

    2014-03-01

    Full Text Available Taking control over work related stress. Mindfulness destresses social workersStress is a major social problem. Due to the increasing workload and the content of the work, social workers are at risk to develop stress (symptoms. The physical and psychological consequences of prolonged stress are serious. By living healthy, optimize working conditions and applying mindfulness, stress can be reduced. Mindfulness is an effective and useful way to reduce stress. It increases the resistance of workers against stress, improves brainfunctions and therefore has a positive effect on the performance. These effects are great, but they are still weakly methodologically substantiated. A pilot project within the youthcare though, was enthusiastically received and proves to be effective against stress symptoms. The exercises that are part of this pilot fit well with the needs of employees. For organizations mindfulnesstrainings are a time-and cost-effective way of structural stress prevention.Grip op werkstress. Mindfulness ontstresst maatschappelijk werkersStress is een omvangrijk maatschappelijk probleem. Door de toenemende werkdruk en de inhoud van het werk zijn maatschappelijk werkers een risicogroep om stress en stressklachten te ontwikkelen. De fysieke en psychische gevolgen die langdurige stress met zich meebrengt zijn ernstig. Door gezond te leven, de arbeidsomstandigheden te optimaliseren en mindfulness toe te passen kan stress terug worden gedrongen. Mindfulness is een effectieve en bruikbare manier om stress te verminderen. Het vergroot de weerbaarheid van werknemers tegen stress, het verbetert de hersenwerking en heeft daardoor een positief effect op het functioneren. Grote effecten dus, maar wel nog methodologisch zwak onderbouwd. Een pilot binnen de jeugdzorg op het gebied van mindfulness is enthousiast ontvangen en blijkt effectief tegen stressklachten. De oefeningen die onderdeel uitmaken van deze pilot sluiten goed aan bij de behoeften van

  14. The impact of unilateral brain damage on anticipatory grip force scaling when lifting everyday objects.

    Science.gov (United States)

    Eidenmüller, S; Randerath, J; Goldenberg, G; Li, Y; Hermsdörfer, J

    2014-08-01

    The scaling of our finger forces according to the properties of manipulated objects is an elementary prerequisite of skilled motor behavior. Lesions of the motor-dominant left brain may impair several aspects of motor planning. For example, limb-apraxia, a tool-use disorder after left brain damage is thought to be caused by deficient recall or integration of tool-use knowledge into an action plan. The aim of the present study was to investigate whether left brain damage affects anticipatory force scaling when lifting everyday objects. We examined 26 stroke patients with unilateral brain damage (16 with left brain damage, ten with right brain damage) and 21 healthy control subjects. Limb apraxia was assessed by testing pantomime of familiar tool-use and imitation of meaningless hand postures. Participants grasped and lifted twelve randomly presented everyday objects. Grip force was measured with help of sensors fixed on thumb, index and middle-finger. The maximum rate of grip force was determined to quantify the precision of anticipation of object properties. Regression analysis yielded clear deficits of anticipation in the group of patients with left brain damage, while the comparison of patient with right brain damage with their respective control group did not reveal comparable deficits. Lesion-analyses indicate that brain structures typically associated with a tool-use network in the left hemisphere play an essential role for anticipatory grip force scaling, especially the left inferior frontal gyrus (IFG) and the premotor cortex (PMC). Furthermore, significant correlations of impaired anticipation with limb apraxia scores suggest shared representations. However, the presence of dissociations, implicates also independent processes. Overall, our findings suggest that the left hemisphere is engaged in anticipatory grip force scaling for lifting everyday objects. The underlying neural substrate is not restricted to a single region or stream; instead it may rely on

  15. Association of grip strength with cardiovascular risk markers.

    Science.gov (United States)

    Gubelmann, Cédric; Vollenweider, Peter; Marques-Vidal, Pedro

    2017-03-01

    Background Mechanisms underlying the association between grip strength and cardiovascular mortality are poorly understood. We aimed to assess the association of grip strength with a panel of cardiovascular risk markers. Design The study was based on a cross-sectional analysis of 3468 adults aged 50-75 years (1891 women) from a population-based sample in Lausanne, Switzerland. Methods Grip strength was measured using a hydraulic hand dynamometer. Cardiovascular risk markers included anthropometry, blood pressure, lipids, glucose, adiposity, inflammatory and other metabolic markers. Results In both genders, grip strength was negatively associated with fat mass (Pearson correlation coefficient: women: -0.170, men: -0.198), systolic blood pressure (women: -0.096, men: -0.074), fasting glucose (women: -0.048, men: -0.071), log-transformed leptin (women: -0.074, men: -0.065), log-transformed high-sensitivity C-reactive protein (women: -0.101, men: -0.079) and log-transformed homocysteine (women: -0.109, men: -0.060). In men, grip strength was also positively associated with diastolic blood pressure (0.068), total (0.106) and low density lipoprotein-cholesterol (0.082), and negatively associated with interleukin-6 (-0.071); in women, grip strength was negatively associated with triglycerides (-0.064) and uric acid (-0.059). After multivariate adjustment, grip strength was negatively associated with waist circumference (change per 5 kg increase in grip strength: -0.82 cm in women and -0.77 cm in men), fat mass (-0.56% in women; -0.27% in men) and high-sensitivity C-reactive protein (-6.8% in women; -3.2% in men) in both genders, and with body mass index (0.22 kg/m(2)) and leptin (-2.7%) in men. Conclusion Grip strength shows only moderate associations with cardiovascular risk markers. The effect of muscle strength as measured by grip strength on cardiovascular disease does not seem to be mediated by cardiovascular risk markers.

  16. Power grip, pinch grip, manual muscle testing or thenar atrophy – which should be assessed as a motor outcome after carpal tunnel decompression? A systematic review

    Directory of Open Access Journals (Sweden)

    Kale Swati

    2007-11-01

    Full Text Available Abstract Background Objective assessment of motor function is frequently used to evaluate outcome after surgical treatment of carpal tunnel syndrome (CTS. However a range of outcome measures are used and there appears to be no consensus on which measure of motor function effectively captures change. The purpose of this systematic review was to identify the methods used to assess motor function in randomized controlled trials of surgical interventions for CTS. A secondary aim was to evaluate which instruments reflect clinical change and are psychometrically robust. Methods The bibliographic databases Medline, AMED and CINAHL were searched for randomized controlled trials of surgical interventions for CTS. Data on instruments used, methods of assessment and results of tests of motor function was extracted by two independent reviewers. Results Twenty-two studies were retrieved which included performance based assessments of motor function. Nineteen studies assessed power grip dynamometry, fourteen studies used both power and pinch grip dynamometry, eight used manual muscle testing and five assessed the presence or absence of thenar atrophy. Several studies used multiple tests of motor function. Two studies included both power and pinch strength and reported descriptive statistics enabling calculation of effect sizes to compare the relative responsiveness of grip and pinch strength within study samples. The study findings suggest that tip pinch is more responsive than lateral pinch or power grip up to 12 weeks following surgery for CTS. Conclusion Although used most frequently and known to be reliable, power and key pinch dynamometry are not the most valid or responsive tools for assessing motor outcome up to 12 weeks following surgery for CTS. Tip pinch dynamometry more specifically targets the thenar musculature and appears to be more responsive. Manual muscle testing, which in theory is most specific to the thenar musculature, may be more

  17. G×E Interaction Influences Trajectories of Hand Grip Strength

    DEFF Research Database (Denmark)

    Petersen, Inge; Pedersen, Nancy L; Rantanen, Taina;

    2016-01-01

    and Environment across Multiple Studies consortium. Growth curve parameters were estimated for same-sex pairs, aged 34-99 (N = 10,681). Fisher's test for mixture distribution of within-monozygotic twin-pair differences (N = 1724) was performed on growth curve parameters. We observed significant gene......-environment interaction on grip strength trajectories. Finally, we compared the variability of within-pair differences of growth curve parameters by APOE haplotypes. Though not statistically significant, the results suggested that APOE ɛ2ɛ2/ɛ2ɛ3 haplotypes might buffer environmental influences on grip strength...

  18. Study of Silicon Photomultipliers for the GRIPS Calorimeter Module

    Directory of Open Access Journals (Sweden)

    Alexei Ulyanov

    2013-01-01

    Full Text Available GRIPS is a proposed gamma-ray (200 keV to 80 MeV astronomy mission, which incorporates a pair-creation and Compton scattering telescope, along with X-ray and infrared telescopes. It will carry out a sensitive all-sky scanning survey, investigating phenomena such as gamma-ray bursts, blazars and core collapse supernovae. The main telescope is composed of a Si strip detector surroundedby a calorimeter with a fast scintillator material. We present the initial results of a study which considers the potential use of silicon photomultipliers in conjunction with the scintillator in the GRIPS calorimeter module.

  19. Prosthetic Hand For Holding Rods, Tools, And Handles

    Science.gov (United States)

    Belcher, Jewell G., Jr.; Vest, Thomas W.

    1995-01-01

    Prosthetic hand with quick-grip/quick-release lever broadens range of specialized functions available to lower-arm amputee by providing improved capabilities for gripping rods, tools, handles, and like. Includes two stationary lower fingers opposed by one pivoting upper finger. Lever operates in conjunction with attached bracket.

  20. Grip and Pinch Strength Norms for Michigan Workers

    Directory of Open Access Journals (Sweden)

    Joel M. Phillips M.S., OTRL

    2013-06-01

    Full Text Available The purpose of this study was to create a norm reference of current grip and pinch strength norms for working-age Michigan adults. This normative study included a convenience sample of 179 volunteers who were employees at car plants in South East Michigan or hospital sites in West Michigan. Participants’ ages ranged from between 20 and 62 years of age with a mean age of 49.15 years. There were 78 females (44% and 101 males (56%. Subjects were classified by gender and in the age categories of ages 20 to 49 years and ages 50-62 years. Grip and pinch strength norms were collected following the American Society of Hand Therapy protocol. The norms from these working adults were calculated with descriptive statistics for males and females in two age classifications: ages 20 to 49 and ages 50 to 62 years. Standard Errors (SE are better than the 1985 norms for both males and females ages 20 to 49 years. SEs are higher than the ages 20 to 49 years’ norms for the ages 50 to 62 years age categories in both males and females. These norms offer a point of comparison for clinicians to use for clients in Michigan who are ages 20 to 62 years and who have a goal to improve their grip strength. Clients’ grip and pinch strength could be compared to their age level or gender norms using the comparison for one standard deviation above, below, or at the means.

  1. Soft shape-adaptive gripping device made from artificial muscle

    Science.gov (United States)

    Hamburg, E.; Vunder, V.; Johanson, U.; Kaasik, F.; Aabloo, A.

    2016-04-01

    We report on a multifunctional four-finger gripper for soft robotics, suitable for performing delicate manipulation tasks. The gripping device is comprised of separately driven gripping and lifting mechanisms, both made from a separate single piece of smart material - ionic capacitive laminate (ICL) also known as artificial muscle. Compared to other similar devices the relatively high force output of the ICL material allows one to construct a device able to grab and lift objects exceeding multiple times its own weight. Due to flexible design of ICL grips, the device is able to adapt the complex shapes of different objects and allows grasping single or multiple objects simultaneously without damage. The performance of the gripper is evaluated in two different configurations: a) the ultimate grasping strength of the gripping hand; and b) the maximum lifting force of the lifting actuator. The ICL is composed of three main layers: a porous membrane consisting of non-ionic polymer poly(vinylidene fluoride-co-hexafluoropropene) (PVdF-HFP), ionic liquid 1-ethyl-3-methylimidazolium trifluoromethane-sulfonate (EMITFS), and a reinforcing layer of woven fiberglass cloth. Both sides of the membrane are coated with a carbonaceous electrode. The electrodes are additionally covered with thin gold layers, serving as current collectors. Device made of this material operates silently, requires low driving voltage (<3 V), and is suitable for performing tasks in open air environment.

  2. Hand Grip Strength Vs. Sprint Effectiveness in Amputee Soccer Players

    Directory of Open Access Journals (Sweden)

    Wieczorek Marta

    2015-12-01

    Full Text Available Amputee soccer is one of the types of soccer designed for the disabled, especially those who have undergone amputations, as well as those with extremity dysfunction. The objective of the study was to find the relationship between hand grip strength and sprint time in amputee soccer players. Thirteen field amputee soccer players participated in the study. A SAEHAN hydraulic hand dynamometer manufactured by Jamar was used for hand grip strength measurements. The sprint running test was conducted over a distance of 30 m. The Fusion Smart Speed System was employed for running time measurements. No statistically significant relationships were found between hand grip strength of the left or right hand, and sprint times over 1, 5, 10, 15, 20, 25 and 30 m. Analysis of the running velocity curve of the subjects showed an interesting profile characterized by a 15 meter-long acceleration phase and a significant velocity increase over a distance of 20 – 25 m. The study suggests that there is no relationship between hand grip strength and sprint effectiveness in amputee soccer players. The specificity of locomotion with the use of elbow crutches among elite Polish amputee soccer players probably accounts for the profile of the sprint velocity curve. Extension of the acceleration phase in the sprint run and a velocity increase in the subsequent part of the run were observed.

  3. Effect of wrist position on young adults pinch grip control

    Directory of Open Access Journals (Sweden)

    Vanessa Luzia Barros de Andrade

    2015-12-01

    Full Text Available Pinch grip is used in a large number of handling activities that require precision and control of an object. The position of the upper arm joints affects the fingers force production in order to handle the object. This study aimed to verify the influence of the wrist position in the production of maximum strength and in the control fingers grip pinch submaximum strength control. Participants were 21 right handed adults (10 male, 18-26 years old. They made two attempts of maximum force production and eight attempts of submaximal force production (four at 20% and four at 40% of maximum strength for pinch grip in three wrist positions: neutral, flexion and extension. The results showed that the production of maximum strength is higher in neutral position compared to wrist flexion and extension and higher for men compared to women. In addition, there was a positive correlation between the length of the hand and the production of maximum strength. The results also indicated that the wrist position did not interfere in the submaximum force control during this task. However, participants showed more difficulty controlling 20% than 40% of maximum strength. The present study showed evidence that the motor units used to produce grip pinch maximum strength cross the wrist joint but those used for the 20% and 40% of maximum strength are present only in the fingers and hand.

  4. GRIPS - Gamma-Ray Imaging, Polarimetry and Spectroscopy

    CERN Document Server

    Greiner, J; Aharonian, F; Ajello, M; Balasz, L G; Barbiellini, G; Bellazzini, R; Bishop, S; Bisnovatij-Kogan, G S; Boggs, S; Bykov, A; DiCocco, G; Diehl, R; Elsässer, D; Foley, S; Fransson, C; Gehrels, N; Hanlon, L; Hartmann, D; Hermsen, W; Hillebrandt, W; Hudec, R; Iyudin, A; Jose, J; Kadler, M; Kanbach, G; Klamra, W; Kiener, J; Klose, S; Kreykenbohm, I; Kuiper, L M; Kylafis, N; Labanti, C; Langanke, K; Langer, N; Larsson, S; Leibundgut, B; Laux, U; Longo, F; Maeda, K; Marcinkowski, R; Marisaldi, M; McBreen, B; McBreen, S; Meszaros, A; Nomoto, K; Pearce, M; Peer, A; Pian, E; Prantzos, N; Raffelt, G; Reimer, O; Rhode, W; Ryde, F; Schmidt, C; Silk, J; Shustov, B M; Strong, A; Tanvir, N; Thielemann, F -K; Tibolla, O; Tierney, D; Trümper, J; Varshalovich, D A; Wilms, J; Wrochna, G; Zdziarski, A; Zoglauer, A

    2011-01-01

    We propose to perform a continuously scanning all-sky survey from 200 keV to 80 MeV achieving a sensitivity which is better by a factor of 40 or more compared to the previous missions in this energy range. The Gamma-Ray Imaging, Polarimetry and Spectroscopy (GRIPS) mission addresses fundamental questions in ESA's Cosmic Vision plan. Among the major themes of the strategic plan, GRIPS has its focus on the evolving, violent Universe, exploring a unique energy window. We propose to investigate $\\gamma$-ray bursts and blazars, the mechanisms behind supernova explosions, nucleosynthesis and spallation, the enigmatic origin of positrons in our Galaxy, and the nature of radiation processes and particle acceleration in extreme cosmic sources including pulsars and magnetars. The natural energy scale for these non-thermal processes is of the order of MeV. Although they can be partially and indirectly studied using other methods, only the proposed GRIPS measurements will provide direct access to their primary photons. G...

  5. GRiP - A flexible approach for calculating risk as a function of consequence, vulnerability, and threat.

    Energy Technology Data Exchange (ETDEWEB)

    Whitfield, R. G.; Buehring, W. A.; Bassett, G. W. (Decision and Information Sciences)

    2011-04-08

    value at an interior (movable) point will be dominated by the value of one vertex as that point moves closer and closer to that one vertex. GRiP is a visualization tool that helps analysts better understand risk and its relationship to consequence, vulnerability, and threat. Estimates of consequence, vulnerability, and threat are external to GRiP; however, the GRiP approach can be linked to models or data that provide estimates of consequence, vulnerability, and threat. For example, the Enhanced Critical Infrastructure Program/Infrastructure Survey Tool produces a vulnerability index (scaled from 0 to 100) that can be used for the vulnerability component of GRiP. We recognize that the values used for risk components can be point estimates and that, in fact, there is uncertainty regarding the exact values of C, V, and T. When we use T = t{sub o} (where t{sub o} is a value of threat in its range), we mean that threat is believed to be in an interval around t{sub o}. Hence, a value of t{sub o} = 0 indicates a 'best estimate' that the threat level is equal to zero, but still allows that it is not impossible for the threat to occur. When t{sub o} = 0 but is potentially small and not exactly zero, there will be little impact on the overall risk value as long as the C and V components are not large. However, when C and/or V have large values, there can be large differences in risk given t{sub o} = 0, and t{sub o} = epsilon (where epsilon is small but greater than a value of zero). We believe this scenario explains the PSA's intuition that risk is not equal to zero when t{sub o} = 0 and C and/or V have large values. (They may also be thinking that if C has an extremely large value, it is unlikely that T is equal to 0; in the terrorist context, T would likely be dependent on C when C is extremely large.) The PSAs are implicitly recognizing the potential that t{sub o} = epsilon. One way to take this possible scenario into account is to replace point estimates for

  6. Adherence to a standardized protocol for measuring grip strength and appropriate cut-off values in adults over 65 years with sarcopenia: a systematic review protocol.

    Science.gov (United States)

    Fox, Benjamin; Henwood, Tim; Schaap, Laura; Bruyère, Olivier; Reginster, Jean-Yves; Beaudart, Charlotte; Buckinx, Fanny; Roberts, Helen; Cooper, Cyrus; Cherubini, Antonio; dellʼAquilla, Giuseppina; Maggio, Marcello; Volpato, Stefano

    2015-10-01

    The objective of this review is to examine the use of grip strength analysis in well and unwell populations in adults 65 years and over as a tool to establish muscle strength in sarcopenia.More specifically, the main review question is:1. What protocol, if any, is most commonly used among older adults with sarcopenia and does this match the standardized protocol suggested in 2011 by Roberts et al.1?Secondary review questions are:2. What are the reported cut-off values being used to determine sarcopenia in older adults, with consideration for ethnic and gender variability?3. Is grip strength, as a tool to measure muscle strength, suitable for people with common comorbidities and geriatric syndromes, such as osteoarthritis, often associated with sarcopenia? Sarcopenia, a commonly used concept in geriatrics and gerontology, is characterized by a loss of muscle mass, muscle strength and/or physical functioning. Prevalence rates vary between 1-39% in community dwelling older populations and 14-33% in long-term care populations. Several epidemiological studies have shown the association of sarcopenia with adverse health outcomes such as falls, disability, hospitalization and mortality. Originally, sarcopenia refers to the loss of muscle mass with aging, which was later complemented with loss of muscle strength and physical functioning.In 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) reported a consensus definition of sarcopenia, which included measurement of low muscle mass and low muscle function (strength or physical performance). This consensus definition can be used to identify sarcopenia patients in clinical practice and to select individuals for clinical trials. Well-designed clinical trials could ultimately lead to effective treatment and prevention strategies for sarcopenia. Since the publication of the consensus report, many studies have adopted this definition, which could potentially lead to better comparison of results between

  7. Effects of Sensory Deficit on Phalanx Force Deviation During Power Grip Post Stroke.

    Science.gov (United States)

    Enders, Leah R; Seo, Na Jin

    2017-01-01

    The effect of sensory deficits on power grip force from individual phalanges was examined. The authors found that stroke survivors with sensory deficits (determined by the Semmes-Weinstein monofilament test) gripped with phalanx force directed more tangential to the object surface, than those without, although both groups had similar motor deficits (Chedoke-McMaster and Fugl-Meyer), grip strength, and skin friction. Altered grip force direction elevates risk of finger slippage against the object thus grip loss/object dropping, hindering activities of daily living. Altered grip force direction was associated with altered muscle activation patterns. In summary, the motor impairment level alone may not describe hand motor control in detail. Information about sensory deficits helps elucidate patients' hand motor control with functional relevance.

  8. Discrimination of handlebar grip samples by fourier transform infrared microspectroscopy analysis and statistics

    Directory of Open Access Journals (Sweden)

    Zeyu Lin

    2017-01-01

    Full Text Available In this paper, the authors presented a study on the discrimination of handlebar grip samples, to provide effective forensic science service for hit and run traffic cases. 50 bicycle handlebar grip samples, 49 electric bike handlebar grip samples, and 96 motorcycle handlebar grip samples have been randomly collected by the local police in Beijing (China. Fourier transform infrared microspectroscopy (FTIR was utilized as analytical technology. Then, target absorption selection, data pretreatment, and discrimination of linked samples and unlinked samples were chosen as three steps to improve the discrimination of FTIR spectrums collected from different handlebar grip samples. Principal component analysis and receiver operating characteristic curve were utilized to evaluate different data selection methods and different data pretreatment methods, respectively. It is possible to explore the evidential value of handlebar grip residue evidence through instrumental analysis and statistical treatments. It will provide a universal discrimination method for other forensic science samples as well.

  9. ANALYTICAL RESEARCH ON THE GRIP VARIATION OF TWO-AXLE CAR

    Directory of Open Access Journals (Sweden)

    Rosen IVANOV

    2016-12-01

    Full Text Available This paper presents a theoretical investigation on the decrease in grip coefficient of a car due to the car mass changes for three different running conditions- straightforward, motion in curve and braking. The grip of two types of cars - with forward and rear traction, equipped with three models of tires are studied. The results show a significant decrease of the grip coefficient in longitudinal and lateral directions.

  10. Control of Precision Grip Force in Lifting and Holding of Low-Mass Objects.

    Directory of Open Access Journals (Sweden)

    Yuichi Hiramatsu

    Full Text Available Few studies have investigated the control of grip force when manipulating an object with an extremely small mass using a precision grip, although some related information has been provided by studies conducted in an unusual microgravity environment. Grip-load force coordination was examined while healthy adults (N = 17 held a moveable instrumented apparatus with its mass changed between 6 g and 200 g in 14 steps, with its grip surface set as either sandpaper or rayon. Additional measurements of grip-force-dependent finger-surface contact area and finger skin indentation, as well as a test of weight discrimination, were also performed. For each surface condition, the static grip force was modulated in parallel with load force while holding the object of a mass above 30 g. For objects with mass smaller than 30 g, on the other hand, the parallel relationship was changed, resulting in a progressive increase in grip-to-load force (GF/LF ratio. The rayon had a higher GF/LF force ratio across all mass levels. The proportion of safety margin in the static grip force and normalized moment-to-moment variability of the static grip force were also elevated towards the lower end of the object mass for both surfaces. These findings indicate that the strategy of grip force control for holding objects with an extremely small mass differs from that with a mass above 30 g. The data for the contact area, skin indentation, and weight discrimination suggest that a decreased level of cutaneous feedback signals from the finger pads could have played some role in a cost function in efficient grip force control with low-mass objects. The elevated grip force variability associated with signal-dependent and internal noises, and anticipated inertial force on the held object due to acceleration of the arm and hand, could also have contributed to the cost function.

  11. Finger pad friction and its role in grip and touch

    Science.gov (United States)

    Adams, Michael J.; Johnson, Simon A.; Lefèvre, Philippe; Lévesque, Vincent; Hayward, Vincent; André, Thibaut; Thonnard, Jean-Louis

    2013-01-01

    Many aspects of both grip function and tactile perception depend on complex frictional interactions occurring in the contact zone of the finger pad, which is the subject of the current review. While it is well established that friction plays a crucial role in grip function, its exact contribution for discriminatory touch involving the sliding of a finger pad is more elusive. For texture discrimination, it is clear that vibrotaction plays an important role in the discriminatory mechanisms. Among other factors, friction impacts the nature of the vibrations generated by the relative movement of the fingertip skin against a probed object. Friction also has a major influence on the perceived tactile pleasantness of a surface. The contact mechanics of a finger pad is governed by the fingerprint ridges and the sweat that is exuded from pores located on these ridges. Counterintuitively, the coefficient of friction can increase by an order of magnitude in a period of tens of seconds when in contact with an impermeably smooth surface, such as glass. In contrast, the value will decrease for a porous surface, such as paper. The increase in friction is attributed to an occlusion mechanism and can be described by first-order kinetics. Surprisingly, the sensitivity of the coefficient of friction to the normal load and sliding velocity is comparatively of second order, yet these dependencies provide the main basis of theoretical models which, to-date, largely ignore the time evolution of the frictional dynamics. One well-known effect on taction is the possibility of inducing stick–slip if the friction decreases with increasing sliding velocity. Moreover, the initial slip of a finger pad occurs by the propagation of an annulus of failure from the perimeter of the contact zone and this phenomenon could be important in tactile perception and grip function. PMID:23256185

  12. Grip strength in healthy caucasian adults: reference values.

    Science.gov (United States)

    Günther, Christian M; Bürger, Alexander; Rickert, Markus; Crispin, Alexander; Schulz, Christoph U

    2008-04-01

    The aim of this study was to update reference data of handgrip strength for healthy adults of both genders spanning a wide age range and to analyze possible factors of influence. Intraindividual and interindividual variations of grip strength and their relation to several anthropometric factors were analyzed in a standardized manner for 769 healthy adults (women, n = 403; men, n = 366) aged between 20 years and 95 years. Measurements were done in neutral position of arm, forearm, and wrist on setting II of a Baseline digital hydraulic dynamometer (NexGen Ergonomics Inc. Quebec, Canada). Mean strength was about 41% less in women (right 29 kg; left 27 kg) than in men (right 49 kg; left 47 kg) resulting in a ratio of left to right hand slightly above .95 in both genders. During the course of life, hand strength develops comparably in both genders peaking at 35 years of age and decreasing continuously further on. Anthropometric variables such as forearm circumference and length, hand size, or body mass showed a positive correlation with grip strength. Body mass index, type of work, and hand dominance showed only a partial positive correlation or no correlation with grip strength. Gender and age, followed by parameters representing body length and obesity, were observed to have the highest predictive value for handgrip strength and were therefore entered into the generation of prediction equations. We recommend side adjustment of measured values for intraindividual comparison and inclusion of information regarding anthropometric characteristics, as well as using gender- and age-adjusted reference values, whereas hand dominance can be neglected. The regression equations we generated might prove to be useful for clinicians or for those who use normative values within software to provide more accurate predictions of strength scores for specific applications.

  13. Design and Evaluation of a Fiber-Optic Grip Force Sensor with Compliant 3D-Printable Structure for (fMRI Applications

    Directory of Open Access Journals (Sweden)

    Tobias L. Bützer

    2016-01-01

    Full Text Available Grip force sensors compatible with magnetic resonance imaging (MRI are used in human motor control and decision-making research, providing objective and sensitive behavioral outcome measures. Commercial sensors are expensive, cover limited force ranges, rely on pneumatic force transmission that cannot detect fast force changes, or are electrically active, which increases the risk of electromagnetic interference. We present the design and evaluation of a low-cost, 3D-printed, inherently MRI-compatible grip force sensor based on a commercial intensity-based fiber-optic sensor. A compliant monobloc structure with flexible hinges transduces grip force to a linear displacement captured by the fiber-optic sensor. The structure can easily be adapted for different force ranges by changing the hinge thickness. A prototype designed for forces up to 800 N was manufactured and showed a highly linear behavior (nonlinearity of 2.37% and an accuracy of 1.57% in a range between zero and 500 N. It can be printed and assembled within one day and for less than $300. Accurate performance was confirmed, both inside and outside a 3 T MRI scanner within a pilot study. Given its simple design allowing for customization of sensing properties and ergonomics for different applications and requirements, the proposed grip force handle offers researchers a valuable scientific tool.

  14. GRIPS - Gamma-Ray Burst Investigation via Polarimetry and Spectroscopy

    CERN Document Server

    Greiner, J

    2008-01-01

    The primary scientific goal of the GRIPS mission is to revolutionize our understanding of the early universe using gamma-ray bursts. We propose a new generation gamma-ray observatory capable of unprecedented spectroscopy over a wide range of gamma-ray energies (200 keV--50 MeV) and of polarimetry (200--1000 keV). Secondary goals achievable by this mission include direct measurements of supernova interiors through gamma-rays from radioactive decays, nuclear astrophysics with massive stars and novae, and studies of particle acceleration near compact stars, interstellar shocks, and clusters of galaxies.

  15. GRIP Database original data - GRIPDB | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us GRIPDB GRIP Database original data Data detail Data name GRIP Database original data DOI 10....18908/lsdba.nbdc01665-006 Description of data contents GRIP Database original data It consists of data table...s and sequences. Data file File name: gripdb_original_data.zip File URL: ftp://ftp.biosciencedbc.jp/archive/gripdb/LATEST/gripdb_orig...e Database Description Download License Update History of This Database Site Policy | Contact Us GRIP Database original data - GRIPDB | LSDB Archive ... ...inal_data.zip File size: 779 KB Simple search URL - Data

  16. Delayed grip relaxation and altered modulation of intracortical inhibition with aging

    Science.gov (United States)

    Motawar, Binal; Stinear, James W.; Lauer, Abigail W.; Ramakrishnan, V. Viswanathan; Seo, Na Jin

    2015-01-01

    Grip relaxation is a voluntary action that requires an increase in short-interval intracortical inhibition (SICI) in healthy young adults, rather than a simple termination of excitatory drive. The way aging affects this voluntary inhibitory action and timing of grip relaxation is currently unknown. The objective of this study was to examine aging-related delays in grip relaxation and SICI modulation for the flexor digitorum superficialis (FDS) muscle during grip relaxation. The main finding was that young adults increased SICI to relax their grips, whereas older adults did not increase SICI with a prolonged grip relaxation time (prelaxation time). A secondary experiment showed that both young and older adults did not change H reflex excitability during grip relaxation. Our data suggest that grip relaxation is mediated by increased cortical inhibitory output in young adults, and aging-related impairment in increasing cortical inhibitory output may hamper timely cessation of muscle activity. Our data also suggest a lesser role of the spinal circuits in grip muscle relaxation. This knowledge may contribute to understanding of aging-related movement deterioration and development of interventions for improving modulation of SICI to improve muscle relaxation and movement coordination. PMID:26686531

  17. Comparative study of maximum isometric grip strength in different sports

    Directory of Open Access Journals (Sweden)

    Noé Gomes Borges Junior

    2009-06-01

    Full Text Available The objective of this study was to compare maximum isometric grip strength (Fmaxbetween different sports and between the dominant (FmaxD and non-dominant (FmaxND hand. Twenty-nine male aikido (AI, jiujitsu (JJ, judo (JU and rowing (RO athletes and 21non-athletes (NA participated in the study. The hand strength test consisted of maintainingmaximum isometric grip strength for 10 seconds using a hand dynamometer. The position of the subjects was that suggested by the American Society of Hand Therapy. Factorial 2X5 ANOVA with Bonferroni correction, followed by a paired t test and Tukey test, was used for statistical analysis. The highest Fmax values were observed for the JJ group when using the dominant hand,followed by the JU, RO, AI and NA groups. Variation in Fmax could be attributed to handdominance (30.9%, sports modality (39.9% and the interaction between hand dominance andsport (21.3%. The present results demonstrated significant differences in Fmax between the JJ and AI groups and between the JJ and NA groups for both the dominant and non-dominant hand. Significant differences in Fmax between the dominant and non-dominant hand were only observed in the AI and NA groups. The results indicate that Fmax can be used for comparisonbetween different sports modalities, and to identify differences between the dominant and nondominanthand. Studies involving a larger number of subjects will permit the identification of differences between other modalities.

  18. Grip pressure measurements during activities of daily life

    Science.gov (United States)

    Sanford, Joe; Young, Carolyn; Popa, Dan; Bugnariu, Nicoleta; Patterson, Rita

    2014-06-01

    Research has expanded human-machine communication methods past direct programming and standard hand- held joystick control. Individual force sensors have been used as a simple means of providing environmental information to a robot and research has shown that more advanced sensitive skins can be viable input devices. These touch sensitive surfaces allow for additional modes of interaction between machines in open, undefined environments. These interactions include object detection for navigation and safety but can also be used for recognition of users command gestures by their machine partner. Key to successful implementation of these gestures is the understanding of varied strategies used for communication and interaction and the development of performance limits. Data of dominant hand grip forces was collected using a Tekscan Grip VersaTek Pressure Measurement System during opening of a door. Analysis of data from 10 male and female subjects is presented. The results of qualitative and quantitative analysis of these data show variability in hand configurations between users. Average data over the cohort is reported. These data will be used in future work to provide human metrology constraints and limits for use in simulation and design of new, physical human-robot interaction systems.

  19. Comparative study of millennials' (age 20-34 years) grip and lateral pinch with the norms.

    Science.gov (United States)

    Fain, Elizabeth; Weatherford, Cara

    Cross-sectional research design. Clinical practice continues to use normative data for grip and pinch measurements that were established in 1985. There is no updated norms despite different hand usage patterns in today's society. Measuring and comparing grip and pinch strengths with normative data is a valid method to determine hand function. This research was implemented to compare the grip and pinch measurements obtained from healthy millennials to the established norms and to describe hand usage patterns for millennials. Grip and lateral pinch measurements were obtained from a sample of 237 healthy millennials (ages 20-34 years). Strength scores were statistically lower that older normative data in all millennial grip strengths, with the exception of the women in the age group of 30-34 years. Specifically, this statistically significant trend was observed in all male grip strengths, as well as in women in the age group of 20-24 years (bilateral grip) and 25-29 years (right grip). However, the lateral pinch data reflected was similar to the older norms with variances of 0.5-1 kg. Current data reflect statistically significant differences from the norms for all male grip measurements, as well as for women in the age group of 20-24 years (bilateral grip) and 25-29 years (right grip). No statistical significance was observed in the independent-sample t tests for the lateral pinch in men of all age groups. Statistical significance was noted for lateral pinch for female age groups for the left hand (20-24 years) and for bilateral lateral pinches (30-34 years). IV. Copyright © 2016 Hanley & Belfus. Published by Elsevier Inc. All rights reserved.

  20. The Effect of Handedness on Grip Strength in Older Adults with Intellectual Disabilities

    Science.gov (United States)

    Oppewal, Alyt; Hilgenkamp, Thessa I. M.; van Wijck, Ruud; Evenhuis, Heleen M.

    2013-01-01

    Grip strength is an important predictor of several health outcomes in the general older population. Grip strength assessment is feasible and reliable in older adults with intellectual disabilities (ID), which makes it a valuable measurement for application in this population. The purpose of this study was to investigate the effect of handedness on…

  1. Children with flat feet have weaker toe grip strength than those having a normal arch

    Science.gov (United States)

    Tashiro, Yuto; Fukumoto, Takahiko; Uritani, Daisuke; Matsumoto, Daisuke; Nishiguchi, Shu; Fukutani, Naoto; Adachi, Daiki; Hotta, Takayuki; Morino, Saori; Shirooka, Hidehiko; Nozaki, Yuma; Hirata, Hinako; Yamaguchi, Moe; Aoyama, Tomoki

    2015-01-01

    [Purpose] This study investigated the relationship between toe grip strength and foot posture in children. [Subjects and Methods] A total of 619 children participated in this study. The foot posture of the participants was measured using a foot printer and toe grip strength was measured using a toe grip dynamometer. Children were classified into 3 groups; flatfoot, normal, and high arch, according to Staheli’s arch index. The differences in demographic data and toe grip strength among each foot posture group were analyzed by analysis of variance. Additionally, toe grip strength differences were analyzed by analysis of covariance, adjusted to body mass index, age, and gender. [Results] The number of participants classified as flatfoot, normal, and high arch were 110 (17.8%), 468 (75.6%), and 41 (6.6%), respectively. The toe grip strength of flatfoot children was significantly lower than in normal children, as shown by both analysis of variance and analysis of covariance. [Conclusion] A significant difference was detected in toe grip strength between the low arch and normal foot groups. Therefore, it is suggested that training to increase toe grip strength during childhood may prevent the formation of flat feet or help in the development of arch. PMID:26696732

  2. Getting a Grip on Numbers: Numerical Magnitude Priming in Object Grasping

    Science.gov (United States)

    Lindemann, Oliver; Abolafia, Juan M.; Girardi, Giovanna; Bekkering, Harold

    2007-01-01

    To investigate the functional connection between numerical cognition and action planning, the authors required participants to perform different grasping responses depending on the parity status of Arabic digits. The results show that precision grip actions were initiated faster in response to small numbers, whereas power grips were initiated…

  3. 16 CFR Figure 5 to Part 1512 - Typical Handbrake Actuator Showing Grip Dimension

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Typical Handbrake Actuator Showing Grip Dimension 5 Figure 5 to Part 1512 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS... Actuator Showing Grip Dimension EC03OC91.072 ...

  4. Hand grip strength in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Jeong M

    2017-08-01

    Full Text Available Moa Jeong,1 Hyung Koo Kang,1 Pamela Song,2 Hye Kyeong Park,1 Hoon Jung,1 Sung-Soon Lee,1 Hyeon-Kyoung Koo1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea Purpose: Hand grip strength (HGS is a simple way of predicting the risk of cardiovascular disease and all-cause mortality in the general population. However, the practical significance of grip strength in patients with COPD is uncertain. The aim of this study was to compare HGS between subjects with and without COPD and to evaluate its clinical relevance in patients with COPD by using a national survey.Methods: Data were collected from the Korean National Health and Nutrition Examination Survey. The study included 421 adults with COPD and 2,542 controls who completed questionnaires, spirometry, and a HGS test. HGS was compared between subjects with and without COPD, and the association between grip strength, lung function, and quality of life (QoL was evaluated.Results: The mean HGS was 33.3±9.1 kg in the COPD group and 29.9±9.5 kg in the non-COPD group; adjusted HGS was 30.9±0.33 kg and 30.9±0.11 kg, respectively (P=0.99. HGS was not related to forced vital capacity (β=0.04, P=0.70 or forced expiratory volume in 1 second (β=0.11, P=0.24 in multivariable analysis. HGS was independently associated with the EQ-5D index, but the relationship was stronger in the COPD group (β=0.30, P<0.001 than in the non-COPD group (β=0.21, P<0.001. The results were similar for each component of the EQ-5D, including mobility (β=-0.25, P<0.001, daily activity (β=-0.19, P=0.01, pain/discomfort (β=-0.32, P<0.001, and anxiety/depression (β=-0.16, P=0.01.Conclusion: HGS was not different between subjects with and without COPD, but was associated with QoL – including mobility, daily activity, pain/discomfort, and anxiety/depression – in patients with COPD. The

  5. Force analysis of the rowing stroke employing two differing oar grips.

    Science.gov (United States)

    Bompa, T O; Hebbelinck, M; Van Gheluwe, B

    1985-06-01

    The velocity of the rowing boat appears to depend on the force which the athlete applies at the handle of the oar. Although force is generated by legs, upper body, and arms, the latter are the only limbs which actually transmit and apply the force against the oar. The force output of the arms seem to be a function of the forearm position used by the athlete while gripping the oar. The traditional gripping technique is with the forearms in pronation. This technique was never challenged or scientifically researched to see whatever a modified one might lead to better efficiency. Consequently, the purpose of this investigation was to analyze whether athletes' force output differed if the gripping technique was changed from pronation to a semiprone grip (one arm prone, the other semiprone). Under the specific conditions of this investigation it was demonstrated that the semiprone position was generating greater force output, thus being superior to the classical prone grip.

  6. Effects of carpal tunnel syndrome on dexterous manipulation are grip type-dependent.

    Science.gov (United States)

    Zhang, Wei; Johnston, Jamie A; Ross, Mark A; Sanniec, Kyle; Gleason, Elizabeth A; Dueck, Amylou C; Santello, Marco

    2013-01-01

    Carpal tunnel syndrome (CTS) impairs sensation of a subset of digits. Although the effects of CTS on manipulation performed with CTS-affected digits have been studied using precision grip tasks, the extent to which CTS affects multi-digit force coordination has only recently been studied. Whole-hand manipulation studies have shown that CTS patients retain the ability to modulate multi-digit forces to object mass, mass distribution, and texture. However, CTS results in sensorimotor deficits relative to healthy controls, including significantly larger grip force and lower ability to balance the torques generated by the digits. Here we investigated the effects of CTS on multi-digit force modulation to object weight when manipulating an object with a variable number of fingers. We hypothesized that CTS patients would be able to modulate digit forces to object weight. However, as different grip types involve the exclusive use of CTS-affected digits ('uniform' grips) or a combination of CTS-affected and non-affected digits ('mixed' grips), we addressed the question of whether 'mixed' grips would reduce or worsen CTS-induced force coordination deficits. The former scenario would be due to adding digits with intact tactile feedback, whereas the latter scenario might occur due to a potentially greater challenge for the central nervous system of integrating 'noisy' and intact tactile feedback. CTS patients learned multi-digit force modulation to object weight regardless of grip type. Although controls exerted the same total grip force across all grip types, patients exerted significantly larger grip force than controls but only for manipulations with four and five digits. Importantly, this effect was due to CTS patients' inability to change the finger force distribution when adding the ring and little fingers. These findings suggest that CTS primarily challenges sensorimotor integration processes for dexterous manipulation underlying the coordination of CTS-affected and non

  7. Effects of carpal tunnel syndrome on dexterous manipulation are grip type-dependent.

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    Full Text Available Carpal tunnel syndrome (CTS impairs sensation of a subset of digits. Although the effects of CTS on manipulation performed with CTS-affected digits have been studied using precision grip tasks, the extent to which CTS affects multi-digit force coordination has only recently been studied. Whole-hand manipulation studies have shown that CTS patients retain the ability to modulate multi-digit forces to object mass, mass distribution, and texture. However, CTS results in sensorimotor deficits relative to healthy controls, including significantly larger grip force and lower ability to balance the torques generated by the digits. Here we investigated the effects of CTS on multi-digit force modulation to object weight when manipulating an object with a variable number of fingers. We hypothesized that CTS patients would be able to modulate digit forces to object weight. However, as different grip types involve the exclusive use of CTS-affected digits ('uniform' grips or a combination of CTS-affected and non-affected digits ('mixed' grips, we addressed the question of whether 'mixed' grips would reduce or worsen CTS-induced force coordination deficits. The former scenario would be due to adding digits with intact tactile feedback, whereas the latter scenario might occur due to a potentially greater challenge for the central nervous system of integrating 'noisy' and intact tactile feedback. CTS patients learned multi-digit force modulation to object weight regardless of grip type. Although controls exerted the same total grip force across all grip types, patients exerted significantly larger grip force than controls but only for manipulations with four and five digits. Importantly, this effect was due to CTS patients' inability to change the finger force distribution when adding the ring and little fingers. These findings suggest that CTS primarily challenges sensorimotor integration processes for dexterous manipulation underlying the coordination of CTS

  8. Comparison of Infant Car Seat grip orientations and lift strategies.

    Science.gov (United States)

    Clamann, Michael; Zhu, Biwen; Beaver, Leah; Taylor, Kinley; Kaber, David

    2012-07-01

    The rear-facing Infant Car Seat (ICS) is designed to meet federal requirements for transporting children less than 1 year old. Typical use includes transfer in and out of a vehicle, which is shown to be a difficult lift. Despite the frequency of this lift, manufacturers provide little guidance for users. Review of relevant literature suggested an ICS featuring an angled handle, promoting a neutral wrist posture, would increase grip stability and decrease lifting effort. Popular press suggested a foot-in-car stance for the ICS lift would do the same. An experiment was conducted in which wrist deviations from neutral posture were recorded along with lifting muscle activation levels (multiple flexor muscles and biceps brachii) and overall perceived exertion for straight versus a new bent handle design and conventional stance versus foot-in-car. Foot position was examined to test the recommendations in the popular press. Surprisingly, wrist deviation was not significantly affected by the new bent handle design (due to compensatory behavior with the straight handle) but was related to foot placement (p=0.04). Results revealed the bent handle to significantly reduce flexor activation compared with the straight handle (p=0.0003); however, the level of biceps activation increased. Biceps activation also significantly increased for foot-in-car stance (p=0.035) but not flexor activation. In general, the bent handle enabled the user to lift the ICS with a steadier grip and less effort. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  9. Effects of kinesio tape compared with non-elastic tape on hand grip strength.

    Science.gov (United States)

    Kim, Ji Young; Kim, Seong Yeol

    2016-05-01

    [Purpose] Many assumptions have been made about taping and several studies have considered tape application methods; however, the true effect of taping on muscle strength remains unclear. Most previous studies compared application techniques using Kinesio tape (KT), but studies that compared muscle strength using non-elastic tape (NT) are limited. Moreover, no studies have applied KT and NT in the same way to assess grip strength in normal subjects. The purpose of this study was to evaluate the immediate effect of application of two tapes with different elastic properties on maximal grip strength in healthy adults. [Subjects and Methods] Twenty healthy adults were divided into two groups (KT and NT). Maximal grip strength was measured with a dynamometer. Forearm extensor muscles of the dominant hand were then taped and subjects were immediately asked to perform hand grip movement with maximum strength in the same standardized manner. [Results] In the KT group, maximal grip strength was significantly increased compared to the initial value; however, in the NT group, there was no significant difference in maximal grip strength. [Conclusion] This study suggests that only Kinesio tape can increase maximal grip strength immediately after application on the extensor region of the forearm.

  10. Using Hand Grip Force as a Correlate of Longitudinal Acceleration Comfort for Rapid Transit Trains.

    Science.gov (United States)

    Guo, Beiyuan; Gan, Weide; Fang, Weining

    2015-07-02

    Longitudinal acceleration comfort is one of the essential metrics used to evaluate the ride comfort of train. The aim of this study was to investigate the effectiveness of using hand grip force as a correlate of longitudinal acceleration comfort of rapid transit trains. In the paper, a motion simulation system was set up and a two-stage experiment was designed to investigate the role of the grip force on the longitudinal comfort of rapid transit trains. The results of the experiment show that the incremental grip force was linearly correlated with the longitudinal acceleration value, while the incremental grip force had no correlation with the direction of the longitudinal acceleration vector. The results also show that the effects of incremental grip force and acceleration duration on the longitudinal comfort of rapid transit trains were significant. Based on multiple regression analysis, a step function model was established to predict the longitudinal comfort of rapid transit trains using the incremental grip force and the acceleration duration. The feasibility and practicably of the model was verified by a field test. Furthermore, a comparative analysis shows that the motion simulation system and the grip force based model were valid to support the laboratory studies on the longitudinal comfort of rapid transit trains.

  11. Effects of kinesio tape compared with non-elastic tape on hand grip strength

    Science.gov (United States)

    Kim, Ji Young; Kim, Seong Yeol

    2016-01-01

    [Purpose] Many assumptions have been made about taping and several studies have considered tape application methods; however, the true effect of taping on muscle strength remains unclear. Most previous studies compared application techniques using Kinesio tape (KT), but studies that compared muscle strength using non-elastic tape (NT) are limited. Moreover, no studies have applied KT and NT in the same way to assess grip strength in normal subjects. The purpose of this study was to evaluate the immediate effect of application of two tapes with different elastic properties on maximal grip strength in healthy adults. [Subjects and Methods] Twenty healthy adults were divided into two groups (KT and NT). Maximal grip strength was measured with a dynamometer. Forearm extensor muscles of the dominant hand were then taped and subjects were immediately asked to perform hand grip movement with maximum strength in the same standardized manner. [Results] In the KT group, maximal grip strength was significantly increased compared to the initial value; however, in the NT group, there was no significant difference in maximal grip strength. [Conclusion] This study suggests that only Kinesio tape can increase maximal grip strength immediately after application on the extensor region of the forearm. PMID:27313372

  12. Kinetic measurements of hand motor impairments after mild to moderate stroke using grip control tasks.

    Science.gov (United States)

    Ye, Yu; Ma, Le; Yan, Tiebin; Liu, Huihua; Wei, Xijun; Song, Rong

    2014-05-11

    The aim of this study is to investigate quantitative outcome measurements of hand motor performance for subjects after mild to moderate stroke using grip control tasks and characterize abnormal flexion synergy of upper extremities after stroke. A customized dynamometer with force sensors was used to measure grip force and calculate rotation torque during the sub-maximal grip control tasks. The paretic and nonpartic sides of eleven subjects after stroke and the dominant sides of ten healthy persons were tested. Their maximal voluntary grip force was measured and used to set sub-maximal grip control tasks at three different target force levels. Force control ability was characterized by the maximal grip force, mean force percentage, coefficient of variation (CV), target deviation ratio (TDR), and rotation torque ratio (RTR). The motor impairments of subjects after stroke were also evaluated using the Fugl-Meyer assessment for upper extremity (FMA-UE) and Wolf Motor Function Test (WMFT). Maximal grip force of the paretic side was significantly reduced as compared to the nonparetic side and the healthy group, while the difference of maximal grip force between the nonparetic side and the healthy group was not significant. TDR and RTR increased for all three groups with increasing target force level. There were significant differences of CV, TDR and RTR between the paretic side and the healthy group at all the force levels. CV, TDR and RTR showed significant negative correlations with FMA-UE and WMFT at 50% of maximum grip force. This study designed a customized dynamometer together with an innovative measurement, RTR, to investigate the hand motor performance of subjects after mild to moderate stroke during force control tasks. And stroke-induced abnormal flexion synergy of wrist and finger muscles could be characterized by RTR. This study also identified a set of kinetic parameters which can be applied to quantitatively assess the hand motor function of subjects after

  13. Temporary threshold shift of vibratory sensation induced by a vibrating handle and its gripping force.

    Science.gov (United States)

    Nishiyama, K; Taoda, K; Yamashita, H; Watanabe, S

    1996-01-01

    This study examines the effect of the force with which a vibrating handle is gripped on the temporary threshold shift of vibratory sensation (TTSv) induced by hand-arm vibration. Six healthy subjects gripped a handle vibrating with a 1.3 octave-band vibration, with a central frequency of 200 Hz and an intensity of 39.2 m/s2. Exposure was for 1 min and 10 min, respectively. Gripping forces for the 1-min exposure were 5 N, 10 N, 40 N and 80 N, respectively, with 0 N push-pull force. Gripping forces for the 10-min exposure were the same as for the 1-min exposure but omitting 80 N. The vibratory sensation threshold at 125 Hz was measured before and after exposure of an exposed fingertip to vibration. The differences measured determine TTSv.t at time t. TTSv.t determines TTSv.0, that is, the temporary threshold shift of vibratory sensation immediately after exposure to vibration according to the estimate made on the basis of the preceding study. The same experimental conditions were repeated 3 times on different days in a soundproof and thermoregulated room. Our findings show that TTSv increases significantly with increasing gripping force. We also determined the quantitative relationships between TTSv.0 and gripping force as described by the equation TTSv.0 = exp(kf x F + Cf). where kt and Cf are constants and F is gripping force. This study revealed the importance of ergonomic design in reducing the force with which a vibrating handle is gripped to prevent an adverse effect of local vibration. The equation devised may help in the quantitative assessment of the effect of reduced gripping force.

  14. Immediate and Delayed Effects of Forearm Kinesio Taping on Grip Strength

    Science.gov (United States)

    Kouhzad Mohammadi, Hosein; Khademi Kalantari, Khosro; Naeimi, Sedighe Sadat; Pouretezad, Mohammad; Shokri, Esmaeil; Tafazoli, Mojdeh; Dastjerdi, Mahboobeh; Kardooni, Leila

    2014-01-01

    Background: Due to the fundamental role of gripping in most upper limb activities, grip strength promotion is a chief goal in the treatment of patients with upper limb musculoskeletal disorders. Kinesio taping is a novel and effective therapeutic technique believed to facilitate muscle contraction through stimulating mechanoreceptors and increasing the sensory feedback around the taped region. Objectives: The present study aimed to identify the best region (flexor, extensor and flexor/extensor regions) and time (immediate, 0.5, 1, 1.5, and 2 hours) of forearm Kinesio taping to obtain the maximum improvement in grip strength. Materials and Methods: In this longitudinal study, 40 healthy men and women (the mean age of 22.3 ± 2.19 years) were selected among students of Shahid Beheshti University of Medical Sciences, Tehran, Iran by simple, nonrandom sampling method. A dynamometer was used to measure grip strength immediately and every 30 minutes during the two hours after I-shaped application of tape (with 50% stretch) to the flexor, extensor, and flexor/extensor forearm muscles. Results: Grip strength was significantly increased in various muscle groups for males (P = 0.002) and females (P = 0.000) of the forearm and at different intervals for males (P = 0.000) and females (P = 0.000). Moreover, in both men and women, tape application to the extensor region provided greater grip strength compared to taping of the flexor and flexor/extensor regions (P = 0.000 for both). Furthermore, the maximum increase in grip strength were 0.5 (10.8% increase, P = 0.001) and 1.5 h (23.9% increase, P = 0.000) after taping in males and females, respectively. Conclusions: Taping the extensor region of forearm is recommended to achieve higher grip strength. Although grip strength increased at a slower pace in females than males, the final values were higher in women. PMID:25389492

  15. GRiP - A flexible approach for calculating risk as a function of consequence, vulnerability, and threat.

    Energy Technology Data Exchange (ETDEWEB)

    Whitfield, R. G.; Buehring, W. A.; Bassett, G. W. (Decision and Information Sciences)

    2011-04-08

    value at an interior (movable) point will be dominated by the value of one vertex as that point moves closer and closer to that one vertex. GRiP is a visualization tool that helps analysts better understand risk and its relationship to consequence, vulnerability, and threat. Estimates of consequence, vulnerability, and threat are external to GRiP; however, the GRiP approach can be linked to models or data that provide estimates of consequence, vulnerability, and threat. For example, the Enhanced Critical Infrastructure Program/Infrastructure Survey Tool produces a vulnerability index (scaled from 0 to 100) that can be used for the vulnerability component of GRiP. We recognize that the values used for risk components can be point estimates and that, in fact, there is uncertainty regarding the exact values of C, V, and T. When we use T = t{sub o} (where t{sub o} is a value of threat in its range), we mean that threat is believed to be in an interval around t{sub o}. Hence, a value of t{sub o} = 0 indicates a 'best estimate' that the threat level is equal to zero, but still allows that it is not impossible for the threat to occur. When t{sub o} = 0 but is potentially small and not exactly zero, there will be little impact on the overall risk value as long as the C and V components are not large. However, when C and/or V have large values, there can be large differences in risk given t{sub o} = 0, and t{sub o} = epsilon (where epsilon is small but greater than a value of zero). We believe this scenario explains the PSA's intuition that risk is not equal to zero when t{sub o} = 0 and C and/or V have large values. (They may also be thinking that if C has an extremely large value, it is unlikely that T is equal to 0; in the terrorist context, T would likely be dependent on C when C is extremely large.) The PSAs are implicitly recognizing the potential that t{sub o} = epsilon. One way to take this possible scenario into account is to replace point estimates for

  16. Stable isotope ratio mass spectrometry and physical comparison for the forensic examination of grip-seal plastic bags.

    Science.gov (United States)

    Taylor, Erica; Carter, James F; Hill, Jenny C; Morton, Carolyn; Daeid, Niamh Nic; Sleeman, Richard

    2008-05-20

    Plastic bags are frequently used to package drugs, explosives and other contraband. There exists, therefore, a requirement in forensic casework to compare bags found at different locations. This is currently achieved almost exclusively by the use of physical comparisons such as birefringence patterns. This paper discusses some of the advantages and shortcomings of this approach, and presents stable isotope ratio mass spectrometry (IRMS) as a supplementary tool for effecting comparisons of this nature. Carbon and hydrogen isotopic data are presented for sixteen grip-seal plastic bags from a wide range of sources, in order to demonstrate the range of values which is likely to be encountered. Both isotopic and physical comparison (specifically birefringence) techniques are then applied to the analysis of rolls of bags from different manufacturing lots from a leading manufacturer. Both approaches are able to associate bags from a common production batch. IRMS can be applied to small fragments which are not amenable to physical comparisons, and is able to discriminate bags which could be confused using birefringence patterns alone. Similarly, in certain cases birefringence patterns discriminate bags with similar isotopic compositions. The two approaches are therefore complementary. When more than one isotopically distinct region exists within a bag (e.g. the grip-seal is distinct from the body) the ability to discriminate and associate bags is greatly increased.

  17. A low cost grip transducer based instrument to quantify fingertip touch force.

    Science.gov (United States)

    Boukhenous, Samir; Attari, Mokhtar

    2007-01-01

    In this paper, a transducer based instrument for fingertip touch force is developed. As a diagnostic tool, the system was coupled with an EMG analog signal processor, which is considered as the main basis of evaluation for motor function impairment. A software program is developed to analyze EMG signal during fingertips effort to obtain valid characteristic parameters with spectral analysis. These parameters are associated with a low cost grip transducer based on Hall Effect component developed for the improvement of fingertip movement during holding objects or training exercises. Thus, the changes on each sensor signal can be detected and monitored with the software interface. The output signal and the EMG analog processor are feeding a high resolution data acquisition system of National Instrument. Preliminary experimental tests have been carried out for the fingertip force grasping according to the Adductor Pollicis muscle (AdP) for controlling the adductive motion of the thumb. The experimental results show that the changes of dynamic fingertip force affect the muscle.

  18. Gripping during climbing of arboreal snakes may be safe but not economical

    Science.gov (United States)

    Byrnes, Greg; Jayne, Bruce C.

    2014-01-01

    On the steep surfaces that are common in arboreal environments, many types of animals without claws or adhesive structures must use muscular force to generate sufficient normal force to prevent slipping and climb successfully. Unlike many limbed arboreal animals that have discrete gripping regions on the feet, the elongate bodies of snakes allow for considerable modulation of both the size and orientation of the gripping region. We quantified the gripping forces of snakes climbing a vertical cylinder to determine the extent to which their force production favoured economy or safety. Our sample included four boid species and one colubrid. Nearly all of the gripping forces that we observed for each snake exceeded our estimate of the minimum required, and snakes commonly produced more than three times the normal force required to support their body weight. This suggests that a large safety factor to avoid slipping and falling is more important than locomotor economy. PMID:25142200

  19. lateral asymmetry ш grip strength: utility of the ten per cent rule

    African Journals Online (AJOL)

    2001-11-01

    Nov 1, 2001 ... between strengths of dominant and non-dominant hands. Such discrepancy in ... methodological approaches in evaluation of grip strength, different .... Relations between stronger hand and hand preference. Stronger hand.

  20. Effect of Putting Grip on Eye and Head Movements During the Golf Putting Stroke

    Directory of Open Access Journals (Sweden)

    George K. Hung

    2003-01-01

    Full Text Available The objective of this article is to determine the effect of three different putting grips (conventional, cross-hand, and one-handed on variations in eye and head movements during the putting stroke. Seven volunteer novice players, ranging in age from 21 to 22 years, participated in the study. During each experimental session, the subject stood on a specially designed platform covered with artificial turf and putted golf balls towards a standard golf hole. The three different types of grips were tested at two distances: 3 and 9 ft. For each condition, 20 putts were attempted. For each putt, data were recorded over a 3-s interval at a sampling rate of 100 Hz. Eye movements were recorded using a helmet-mounted eye movement monitor. Head rotation about an imaginary axis through the top of the head and its center-of-rotation was measured by means of a potentiometer mounted on a fixed frame and coupled to the helmet. Putter-head motion was measured using a linear array of infrared phototransistors embedded in the platform. The standard deviation (STD, relative to the initial level was calculated for eye and head movements over the duration of the putt (i.e., from the beginning of the backstroke, through the forward stroke, to impact. The averaged STD for the attempted putts was calculated for each subject. Then, the averaged STDs and other data for the seven subjects were statistically compared across the three grip conditions. The STD of eye movements were greater (p < 0.1 for conventional than cross-hand (9 ft and one-handed (3 and 9 ft grips. Also, the STD of head movements were greater (p < 0.1; 3 ft for conventional than cross-hand and one-handed grips. Vestibulo-ocular responses associated with head rotations could be observed in many 9 ft and some 3 ft putts. The duration of the putt was significantly longer (p < 0.05; 3 and 9 ft for the one-handed than conventional and cross-hand grips. Finally, performance, or percentage putts made, was

  1. Adaptive grip force is modulated by subthalamic beta activity in Parkinson's disease patients

    Directory of Open Access Journals (Sweden)

    Lukas L. Imbach

    2015-01-01

    Conclusion: The time-locked suppression of beta oscillatory activity in the STN is in line with previous reports of beta ERD prior to voluntary movements. Our results show that the STN is involved in anticipatory grip force control in PD patients. The difference in the phasic beta ERD between the two tasks and the reduction of cortico-subthalamic synchronization suggests that qualitatively different neuronal network states are involved in different grip force control tasks.

  2. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.

    Science.gov (United States)

    Lu, Wei; Ziff, Edward B

    2005-08-04

    PICK1 and ABP/GRIP bind to the AMPA receptor (AMPAR) GluR2 subunit C terminus. Transfer of the receptor from ABP/GRIP to PICK1, facilitated by GluR2 S880 phosphorylation, may initiate receptor trafficking. Here we report protein interactions that regulate these steps. The PICK1 BAR domain interacts intermolecularly with the ABP/GRIP linker II region and intramolecularly with the PICK1 PDZ domain. Binding of PKCalpha or GluR2 to the PICK1 PDZ domain disrupts the intramolecular interaction and facilitates the PICK1 BAR domain association with ABP/GRIP. Interference with the PICK1-ABP/GRIP interaction impairs S880 phosphorylation of GluR2 by PKC and decreases the constitutive surface expression of GluR2, the NMDA-induced endocytosis of GluR2, and recycling of internalized GluR2. We suggest that the PICK1 interaction with ABP/GRIP is a critical step in controlling GluR2 trafficking.

  3. Adductor pollicis muscle and hand grip strength: potential methods of nutritional assessment in outpatients with stroke

    Directory of Open Access Journals (Sweden)

    Débora Rocha Oliveira

    2010-12-01

    Full Text Available Objective: To evaluate and compare the effectiveness of different methods used for nutritional assessment of outpatients who had hemiplegic stroke. Methods: A cross-section study with adult and elderly patients of both genders enrolled in a rehabilitation center. The analyzed variables were anthropometric measurements, bioelectrical impedance, hand grip strength and thickness of the adductor pollicis muscle. The Pearson χ2 test was used to check the association between variables with a significance level of α = 5%. Results: When evaluating the association between indicators of muscle mass, it was observed that the hand grip strength in both genders was positively correlated with arm muscle circumference (p = 0.0196 and lean mass (p = 0.0002. Fat mass measured by the bioelectrical impedance method already showed a significant inverse relationship with the grip (r = -0.3879. The thickness of the adductor pollicis muscle showed significant association with lean mass (p = 0.0052 and hand grip (p = 0.0024. Conclusion: In this study, the hand grip strength and thickness of the adductor pollicis muscle were well correlated with measurements determined by anthropometry and bioimpedance. The results show the applicability of grip strength and thickness of the adductor pollicis muscle in clinical practice as nutritional assessment methods for this population, especially elderly patients, since they detect functional changes not captured by other parameters in the short term and are important for early identification of risk nutrition.

  4. [Isometric grip strength and social gerontological research: results and analytic potentials of SHARE and SOEP].

    Science.gov (United States)

    Hank, K; Jürges, H; Schupp, J; Wagner, G G

    2009-04-01

    This paper shows that the measurement of hand grip strength provides a non-invasive and reliable objective health indicator for social science research and is easy to collect in general population surveys. Grip strength is not only a useful complement of self-reported indicators of health, but it also exhibits a considerable predictive power with regard to a number of further relevant variables for social gerontological research, such as mortality risks. New data from the 2004 Survey of Health, Ageing and Retirement in Europe (SHARE) and the 2006 wave of the German Socio-Economic Panel Study (SOEP) allow insightful methodological and very first substantive cross-sectional analyses of grip strength in Germany. The focus of the present study is on the analysis of individuals aged 50 or older. The experience of both surveys when measuring grip strength is consistently positive, particularly with regard to the respondents' feedback. Major determinants of isometric grip strength are - beyond the individual's gender - age, body size and weight. A multivariate analysis also provides evidence for a clear positive association between various health indicators and grip strength.

  5. Control of grip force and vertical posture while holding an object and being perturbed.

    Science.gov (United States)

    Chen, Bing; Lee, Yun-Ju; Aruin, Alexander S

    2016-11-01

    We investigated motor control perspectives of coordinating maintenance of posture and application of grip force when holding an object and being perturbed. Ten subjects stood on the force platform holding an instrumented object in their dominant hand and were exposed to an external perturbation applied to their shoulders. Task demands were manipulated by positioning a slippery cap on top of the instrumented object. Grip force applied to the object, the object acceleration and the center of pressure (COP) were recorded and analyzed during the time intervals typical for the anticipatory (APA) and compensatory (CPA) components of postural control. Onsets of grip force were seen before the onsets of the COP displacement and initiation of movements of the handheld object during the APA phase of postural control, while the onsets of maximum grip force preceded the maximum COP displacement during the CPA phase. When the task demands increased by holding a handheld object with the slippery cap, subjects tended to generate grip force earlier and of a smaller magnitude; also, the COP displacement in the APA phase was smaller as compared to holding a handheld object only. The outcome provides a foundation for future studies of maintenance of vertical posture in people with impairments of balance and grip force control when holding an object and being perturbed.

  6. Hold, grasp, clutch or grab: consumer grip choices during food container opening.

    Science.gov (United States)

    Rowson, J; Yoxall, A

    2011-07-01

    Society is ageing and sadly that ageing leads to a host of issues, not least a society in which the majority are likely to have some loss of strength and dexterity. This can lead to complications in undertaking everyday tasks such as using transport, bathing or even handling and opening food. Packaging has to provide a multitude of services; to protect and preserve the product, to provide information to the consumer and not least to allow access to the contents. This access to packaging--or 'openability'--has become a significant issue for designers and manufacturers with the change in demographics as described above. Understanding the choices consumers make in how they manipulate packaging can help designers produce packaging that is more able to meet the requirements of modern society. Studies previously undertaken by the authors showed that consumers did use different grips when opening packaging and that certain grips were theoretically more comfortable and stronger than others. This paper outlines a further study whereby consumers were asked to apply the most common grips to a specially designed torque measuring device. Details were taken about the consumers: age, gender, occupation, hand size, plus their preferred grip choice for packaging of this type. The study showed that typically women chose a grip that maximised their opportunity of opening the closure and that this grip choice was more limited than that available for men. This has implications for inclusive design of many everyday products.

  7. Posture, Flexibility and Grip Strength in Horse Riders

    Directory of Open Access Journals (Sweden)

    Hobbs Sarah Jane

    2014-10-01

    Full Text Available Since the ability to train the horse to be ambidextrous is considered highly desirable, rider asymmetry is recognized as a negative trait. Acquired postural and functional asymmetry can originate from numerous anatomical regions, so it is difficult to suggest if any is developed due to riding. The aim of this study was therefore to assess symmetry of posture, strength and flexibility in a large population of riders and to determine whether typical traits exist due to riding. 127 right handed riders from the UK and USA were categorized according to years riding (in 20 year increments and their competition level (using affiliated test levels. Leg length, grip strength and spinal posture were measured and recorded by a physiotherapist. Standing and sitting posture and trunk flexibility were measured with 3-D motion capture technology. Right-left differences were explored in relation to years riding and rider competitive experience. Significant anatomical asymmetry was found for the difference in standing acromion process height for a competition level (-0.07±1.50 cm Intro/Prelim; 0.02±1.31 cm Novice; 0.43±1.27 cm Elementary+; p=0.048 and for sitting iliac crest height for years riding (-0.23±1.36 cm Intro/Prelim; 0.01±1.50 cm Novice; 0.86±0.41 cm Elementary+; p=0.021. For functional asymmetry, a significant interaction was found for lateral bending ROM for years riding x competition level (p=0.047. The demands on dressage riders competing at higher levels may predispose these riders to a higher risk of developing asymmetry and potentially chronic back pain rather than improving their symmetry

  8. Genetic influences on the development of grip strength in adolescence.

    Science.gov (United States)

    Isen, Joshua; McGue, Matt; Iacono, William

    2014-06-01

    Enhanced physical strength is a secondary sex characteristic in males. Sexual dimorphism in physical strength far exceeds sex differences in stature or total body mass, suggesting a legacy of intense sexual selection. Upper-body strength is a particularly promising marker of intrasexual competitiveness in young men. Consequently, it is assumed that sex-influenced gene expression contributes to the development of physical strength. It is unclear, however, whether the underlying sources of individual differences in strength development are comparable across sex. We obtained three measurements of hand-grip strength (HGS) over a six-year period spanning adolescence in male and female same-sex twins (N = 2,513). Biometrical latent growth models were used to partition the HGS variance at age 11 (intercept) and its growth over time (slope) into genetic and environmental components. Results demonstrated that variance around the intercept was highly heritable in both males and females (88% and 79%, respectively). In males, variance around the slope exceeded that of the intercept, while the reverse held for females. Additive genetic effects accounted for most (80%) of the variance around the slope in males, but were of less importance in females (heritability = 28%). Absolute genetic variance around the slope was nearly nine-fold higher in males. This striking disparity suggests that the developmental processes shaping HGS growth are different between the sexes. We propose that this might account for the sex-specific pattern of associations between HGS and external measures (e.g., digit ratio and physical aggression) typically reported in the literature. Our results underscore the role of endogenous androgenic influences in the development of physical strength.

  9. Posture, flexibility and grip strength in horse riders.

    Science.gov (United States)

    Hobbs, Sarah Jane; Baxter, Joanna; Broom, Louise; Rossell, Laura-Ann; Sinclair, Jonathan; Clayton, Hilary M

    2014-09-29

    Since the ability to train the horse to be ambidextrous is considered highly desirable, rider asymmetry is recognized as a negative trait. Acquired postural and functional asymmetry can originate from numerous anatomical regions, so it is difficult to suggest if any is developed due to riding. The aim of this study was therefore to assess symmetry of posture, strength and flexibility in a large population of riders and to determine whether typical traits exist due to riding. 127 right handed riders from the UK and USA were categorized according to years riding (in 20 year increments) and their competition level (using affiliated test levels). Leg length, grip strength and spinal posture were measured and recorded by a physiotherapist. Standing and sitting posture and trunk flexibility were measured with 3-D motion capture technology. Right-left differences were explored in relation to years riding and rider competitive experience. Significant anatomical asymmetry was found for the difference in standing acromion process height for a competition level (-0.07±1.50 cm Intro/Prelim; 0.02±1.31 cm Novice; 0.43±1.27 cm Elementary+; p=0.048) and for sitting iliac crest height for years riding (-0.23±1.36 cm Intro/Prelim; 0.01±1.50 cm Novice; 0.86±0.41 cm Elementary+; p=0.021). For functional asymmetry, a significant interaction was found for lateral bending ROM for years riding x competition level (p=0.047). The demands on dressage riders competing at higher levels may predispose these riders to a higher risk of developing asymmetry and potentially chronic back pain rather than improving their symmetry.

  10. Normative Measurements of Grip and Pinch Strengths of 21st Century Korean Population

    Directory of Open Access Journals (Sweden)

    Jin Hee Shim

    2013-01-01

    Full Text Available BackgroundMeasuring grip and pinch strength is an important part of hand injury evaluation. Currently, there are no standardized values of normal grip and pinch strength among the Korean population, and lack of such data prevents objective evaluation of post-surgical recovery in strength. This study was designed to establish the normal values of grip and pinch strength among the healthy Korean population and to identify any dependent variables affecting grip and pinch strength.MethodsA cross-sectional study was carried out. The inclusion criterion was being a healthy Korean person without a previous history of hand trauma. The grip strength was measured using a Jamar dynamometer. Pulp and key pinch strength were measured with a hydraulic pinch gauge. Intra-individual and inter-individual variations in these variables were analyzed in a standardized statistical manner.ResultsThere were a total of 336 healthy participants between 13 and 77 years of age. As would be expected in any given population, the mean grip and pinch strength was greater in the right hand than the left. Male participants (137 showed mean strengths greater than female participants (199 when adjusted for age. Among the male participants, anthropometric variables correlated positively with grip strength, but no such correlations were identifiable in female participants in a statistically significant way.ConclusionsObjective measurements of hand strength are an important component of hand injury evaluation, and population-specific normative data are essential for clinical and research purposes. This study reports updated normative hand strengths of the South Korean population in the 21st century.

  11. AtGRIP protein locates to the secretory vesicles of trans Golgi-network in Arabidopsis root cap cells

    Institute of Scientific and Technical Information of China (English)

    CHEN Ying; ZHANG Wei; ZHAO Lei; LI Yan

    2008-01-01

    GRIP domain proteins, locating to the trans-Golgi network, are thought to play an essential role in Golgi apparatus trafficking in yeast and animal cells. In the present study, AtGRIP cDNA was amplified by reverse transcriptase PCR from RNA isolated from Arabidopsis seedling. The GST fusion protein of AtGRIP was affinity-purified and its rabbit polyclonal antibody was obtained. Immuno-blotting with the purified anti-AtGRIP polyclonal antibody demonstrated that the molecular mass of AtGRIP protein is about 92 kD, and its expression is not tissue-specific in Arabidopsis. Immunoflourescent labeling and confocal microscopy revealed that the AtGRIP protein was co-localized with Golgi stacks in Arabidop-sis root cells. Immuno-gold labeling and electron microscopy observation showed that AtGRIP protein was mainly located to the membrane of the secretory vesicles of trans-Golgi network in Arabidopsis root cap cells. Taken together, these results indicate that the localization of GRIP domain proteins be-tween plants and animal cells are conserved. These results also suggest that the AtGRIP may be in-volved in regulating the formation or sorting of Golgi-associated vesicles in plant cells.

  12. Grip type and task goal modify reach-to-grasp performance in post-stroke hemiparesis

    Science.gov (United States)

    Schaefer, Sydney Y.; DeJong, Stacey L.; Cherry, Kendra M.; Lang, Catherine E.

    2011-01-01

    This study investigated whether grip type and/or task goal influenced reaching and grasping performance in post-stroke hemiparesis. Sixteen adults with post-stroke hemiparesis and twelve healthy adults reached to and grasped a cylindrical object using one of two grip types (3-finger or palmar) to achieve one of two task goals (hold or lift). Performance of the stroke group was characteristic of hemiparetic limb movement during reach-to-grasp, with more curved handpaths and slower velocities compared to the control group. These effects were present regardless of grip type or task goal. Other measures of reaching (reach time and reach velocity at object contact) and grasping (peak thumb-index finger aperture during the reach and peak grip force during the grasp) were differentially affected by grip type, task goal, or both, despite the presence of hemiparesis, providing new evidence that changes in motor patterns after stroke may occur to compensate for stroke-related motor impairment. PMID:22357103

  13. Grip pressure distributions and associated variability in golf: a two-club comparison.

    Science.gov (United States)

    Langlais, Sean M; Broker, Jeffrey P

    2014-06-01

    Teaching and playing professionals offer multiple theories concerning the manner in which forces should be applied to the handle of the club during the golf swing. This study extends recent research concerning grip pressures and forces in golf, with the purpose of exploring the similarities and differences between force profiles for a 7-iron and driver swung by proficient golfers. A secondary purpose was to further analyze the way that golfers use grip forces to manipulate the club. Grip forces were measured on eight low handicap golfers (USGA indexes 0 to 7) swinging their own 7-irons and drivers. In total, lead-hand and trail-hand grip forces were isolated as well as anatomically specific forces within the hands. Force profile variability across multiple swings for each golfer and between golfers characterized consistencies and important differences. Correlations between 7-iron and driver force profiles characterized force 'signatures.' The data highlight large fluctuations in grip forces during the swing. Marked differences between participants were observed, involving force magnitudes and phasing. Dominant forces arose primarily from the lead hand, specifically the last three fingers. Force profiles were highly repeatable across swings for a golfer (standard deviations high (r2 = 0.86). Notably, within swing force variability was greatest during club acceleration, but dramatically decreased at impact.

  14. Effects of Taping on Pain, Grip Strength and Wrist Extension Force in Patients with Tennis Elbow

    Science.gov (United States)

    Shamsoddini, Alireza; Hollisaz, Mohammad Taghi

    2013-01-01

    Background Tennis elbow (TE) is a common musculotendinous degenerative disorder of the extensor origin at the lateral humeral epicondyle. Different modes of treatment are used for management of tennis elbow. Objectives This study investigated the effect of the taping technique (TT) on pain, grip strength and wrist extension force in treatment of tennis elbow. Patients and Methods Thirty patients (16 men /14 women with a mean age of 32.2 years) with tennis elbow of their dominant arm participated in this study. Outcome measures were assessment of pain at the lateral aspect of the elbow, grip strength and wrist extension force before and five to ten minutes after application of elbow tape on the affected and unaffected arms. A Visual Analog Scale was used to assess pain. A dynamometer and a hand-held dynamometer were used for evaluation of grip strength and wrist extension force, respectively. Results Among the variables, significant differences were found in wrist extension forces between effected and unaffected arms (P = 0.02). Changes in grip strength showed statically significant improvements in the affected arm compared to the unaffected arm (P = 0.03). Also, in assessment of pain at the lateral epicondyle, the mean change between affected and unaffected arms was significant, with P = 0.001. Conclusions The taping technique, as applied in this study demonstrates an impressive effect on wrist extension force and grip strength of patients with TE. Elbow taping also reduces pain at the lateral aspect of the elbow in these patients. PMID:24350156

  15. Proposed technique for inguinal hernia repair with self-gripping mesh: avoiding fixation to undesired structures.

    Science.gov (United States)

    Porrero, J L; Cano-Valderrama, O; Castillo, M J; Alonso, M T

    2015-10-01

    Self-gripping meshes have been developed to avoid fixing sutures during inguinal hernia repair. Operative time is shorter when using a self-gripping mesh than with conventional Lichtenstein repair. However, these meshes can be difficult to handle because they fix to undesired structures. The aim of this report is to describe a new technique to avoid this problem. Inguinal hernia dissection is made as usual. Once dissection is finished, a Parietex ProGrip(®) (Covidien, Dublin, Ireland) flat sheet mesh is cut depending on the size needed. A small split is made between the lower and medium third of the mesh to mark where the split for the spermatic cord will be. Using this mark, the upper third of the mesh is folded over the medium third, hiding the microgrips that make this a self-gripping mesh. In this way, only the lower third of the mesh has the microgrips exposed and the mesh can be fixed to the pubic bone and inguinal ligament without fixation to undesired structures. Once the lower third of the mesh is fixed, the split for the spermatic cord is completed and the upper part of the mesh is passed below the spermatic cord. Then, the mesh is unfolded to expose the microgrips again and the medium and upper third of the mesh are descended to its final position. This proposed technique for inguinal hernia repair with self-gripping mesh makes the surgery easier, avoiding mesh fixation to undesired structures.

  16. Slip detection and grip adjustment using optical tracking in prosthetic hands.

    Science.gov (United States)

    Roberts, Luke; Singhal, Girish; Kaliki, Rahul

    2011-01-01

    We have designed a closed loop control system that adjusts the grasping force of a prosthetic hand based on the amount of object slip detected by an optical tracking sensor. The system was designed for the i-Limb (a multi-fingered prosthetic hand from Touch Bionics Inc.) and is comprised of an optical sensor embedded inside a silicone prosthetic glove and a control algorithm. In a proof of concept study to demonstrate the effectiveness of optical tracking in slip sensing, we record slip rate while increasing the weight held in the grasp of the hand and compare two cases: grip adjustment on and grip adjustment off. The average slip rate was found to be 0.314 slips/(s · oz) without grip adjustment and 0.0411 slips/(s · oz) with grip adjustment. This paper discusses the advantages of the optical approach in slip detection and presents the experiment and results utilizing the optical sensor and grip control algorithm.

  17. Extraction of time and frequency features from grip force rates during dexterous manipulation.

    Science.gov (United States)

    Mojtahedi, Keivan; Fu, Qiushi; Santello, Marco

    2015-05-01

    The time course of grip force from object contact to onset of manipulation has been extensively studied to gain insight into the underlying control mechanisms. Of particular interest to the motor neuroscience and clinical communities is the phenomenon of bell-shaped grip force rate (GFR) that has been interpreted as indicative of feedforward force control. However, this feature has not been assessed quantitatively. Furthermore, the time course of grip force may contain additional features that could provide insight into sensorimotor control processes. In this study, we addressed these questions by validating and applying two computational approaches to extract features from GFR in humans: 1) fitting a Gaussian function to GFR and quantifying the goodness of the fit [root-mean-square error, (RMSE)]; and 2) continuous wavelet transform (CWT), where we assessed the correlation of the GFR signal with a Mexican Hat function. Experiment 1 consisted of a classic pseudorandomized presentation of object mass (light or heavy), where grip forces developed to lift a mass heavier than expected are known to exhibit corrective responses. For Experiment 2, we applied our two techniques to analyze grip force exerted for manipulating an inverted T-shaped object whose center of mass was changed across blocks of consecutive trials. For both experiments, subjects were asked to grasp the object at either predetermined or self-selected grasp locations ("constrained" and "unconstrained" task, respectively). Experiment 1 successfully validated the use of RMSE and CWT as they correctly distinguished trials with versus without force corrective responses. RMSE and CWT also revealed that grip force is characterized by more feedback-driven corrections when grasping at self-selected contact points. Future work will examine the application of our analytical approaches to a broader range of tasks, e.g., assessment of recovery of sensorimotor function following clinical intervention, interlimb

  18. Corticomuscular coherence during hand gripping with DBS and medication in PD patients

    DEFF Research Database (Denmark)

    Sridharan, Kousik Sarathy; Højlund, Andreas; Johnsen, Erik Lisbjerg

    (MEG) from six PD patients performing hand gripping during DBS ON and medicated (levodopa, MED ON) conditions and from ten age-matched healthy controls. Participants performed isotonic contractions (hand gripping) with their right hand, and electromyography (EMG) was recorded from the extensor...... digitorum communis muscle with a belly-tendon montage. We calculated the mean-squared coherence between MEG and the rectified EMG signals. For each group and condition, we selected the maximum CMC value in the beta range (13-30 Hz) within the average of an a priori selection of nine left sensorimotor...

  19. Wear and Grip Loss Evaluation of High Chromium Welding Deposits Applied on Sugar Cane Rolls1

    OpenAIRE

    Diaz Millan, Sebastian; Rugbeño S.A.S; Aguilar Castro, Yesid; Escuela de Ingeniería de Materiales, Universidad del Valle, Cali, Colombia; Casanova García, Gonzalo Fernando; Escuela de Ingeniería Mecánica,Universidad del Valle, Cali, Colombia

    2015-01-01

    Wear on sugar cane rolls is an expensive maintenance problem for the sugar cane industry. Wear produces loss of sucrose extraction and loss of grip of the roll on the bagasse. This paper presents the evaluation of wear and loss of grip of hypoeutectic and hypereutectic high chromium welding deposits applied on ASTM A-36 steel and gray cast iron. A modified ASTM G-65 standard test was used. Wear was produced by the abrasive action of wet bagasse with three levels of mineral extraneous matter. ...

  20. The determination of the operating range of a twin-grip control yoke through biomechanical means

    Science.gov (United States)

    Gaertner, K. P.

    1978-01-01

    A twin-grip control yoke was designed as an ergonomic case study that allows dual axis control inputs, both axes being rotational. Inputs are effected by rotating the grips. How the handles were designed with respect to their shape and size and how the angular range of the control yoke in both rotational axes was evaluated. The control yoke which requires two-hand operation was tested to determine its operating range. The intention of this investigation was to find out the optimal form of the control yoke and the maximum permissible range in both rotating axes. In these experiments controls had no spring resistance.

  1. Grip strength and lower limb extension power in 19-72-year-old Danish men and women

    DEFF Research Database (Denmark)

    Aadahl, Mette; Beyer, Nina; Linneberg, Allan

    2011-01-01

    To assess muscular fitness by hand grip strength (HGS) and lower limb extension power (LEP) and to explore associations with age, leisure time physical activity (LTPA) and body composition.......To assess muscular fitness by hand grip strength (HGS) and lower limb extension power (LEP) and to explore associations with age, leisure time physical activity (LTPA) and body composition....

  2. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

    DEFF Research Database (Denmark)

    Willems, Sara M; Wright, Daniel J.; Day, Felix R

    2017-01-01

    Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 1...

  3. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

    NARCIS (Netherlands)

    Willems, Sara M.; Wright, D.J.; Day, Felix R.; Trajanoska, Katerina; Joshi, P.K.; Morris, John A.; Matteini, Amy M.; Garton, Fleur C.; Grarup, Niels; Oskolkov, Nikolay; Thalamuthu, Anbupalam; Mangino, Massimo; Liu, Jun; Demirkan, Ayse; Lek, Monkol; Xu, Liwen; Wang, Guan; Oldmeadow, Christopher; Gaulton, Kyle J.; Lotta, Luca A.; Miyamoto-Mikami, Eri; Rivas, Manuel A.; White, Tom; Loh, Po Ru; Aadahl, Mette; Amin, Najaf; Attia, John R.; Austin, Krista; Benyamin, Beben; Brage, Søren; Cheng, Yu Ching; Ciȩszczyk, Paweł; Derave, Wim; Eriksson, Karl Fredrik; Eynon, Nir; Linneberg, Allan; Lucia, Alejandro; Massidda, Myosotis; Mitchell, Braxton D.; Miyachi, Motohiko; Murakami, Haruka; Padmanabhan, Sandosh; Pandey, Ashutosh; Papadimitriou, Ioannis; Rajpal, Deepak K.; Sale, Craig; Schnurr, Theresia M.; Sessa, Francesco; Shrine, Nick; Tobin, Martin D.; Varley, Ian; Wain, Louise V.; Wray, Naomi R.; Lindgren, Cecilia M.; MacArthur, Daniel G.; Waterworth, Dawn M.; McCarthy, Mark I.; Pedersen, Oluf; Khaw, Kay Tee; Kiel, Douglas P.; Pitsiladis, Yannis; Fuku, Noriyuki; Franks, Paul W.; North, Kathryn N.; Duijn, Van C.M.; Mather, Karen A.; Hansen, Torben; Hansson, Ola; Spector, Tim D.; Murabito, Joanne M.; Richards, J.B.; Rivadeneira, Fernando; Langenberg, Claudia; Perry, John R.B.; Wareham, Nick J.; Scott, Robert A.; Oei, Ling; Zheng, Hou Feng; Forgetta, Vincenzo; Leong, Aaron; Ahmad, Omar S.; Laurin, Charles; Mokry, Lauren E.; Ross, Stephanie; Elks, Cathy E.; Bowden, Jack; Warrington, Nicole M.; Murray, Anna; Ruth, Katherine S.; Tsilidis, Konstantinos K.; Medina-Gómez, Carolina; Estrada, Karol; Bis, Joshua C.; Chasman, Daniel I.; Demissie, Serkalem; Enneman, Anke W.; Hsu, Yi Hsiang; Ingvarsson, Thorvaldur; Kähönen, Mika; Kammerer, Candace; Lacroix, Andrea Z.; Li, Guo; Liu, Ching Ti; Liu, Yongmei; Lorentzon, Mattias; Mägi, Reedik; Mihailov, Evelin; Milani, Lili; Moayyeri, Alireza; Nielson, Carrie M.; Sham, Pack Chung; Siggeirsdotir, Kristin; Sigurdsson, Gunnar; Stefansson, Kari; Trompet, Stella; Thorleifsson, Gudmar; Vandenput, Liesbeth; Velde, Van Der Nathalie; Viikari, Jorma; Xiao, Su Mei; Zhao, Jing Hua; Evans, Daniel S.; Cummings, Steven R.; Cauley, Jane; Duncan, Emma L.; Groot, De Lisette C.P.G.M.; Esko, Tonu; Gudnason, Vilmundar; Harris, Tamara B.; Jackson, Rebecca D.; Jukema, J.W.; Ikram, Arfan M.A.; Karasik, David; Kaptoge, Stephen; Kung, Annie Wai Chee; Lehtimäki, Terho; Lyytikäinen, Leo Pekka; Lips, Paul; Luben, Robert; Metspalu, Andres; Meurs, van Joyce B.; Minster, Ryan L.; Orwoll, Erick; Oei, Edwin; Psaty, Bruce M.; Raitakari, Olli T.; Ralston, Stuart W.; Ridker, Paul M.; Robbins, John A.; Smith, Albert V.; Styrkarsdottir, Unnur; Tranah, Gregory J.; Thorstensdottir, Unnur; Uitterlinden, Andre G.; Zmuda, Joseph; Zillikens, M.C.; Ntzani, Evangelia E.; Evangelou, Evangelos; Ioannidis, John P.A.; Evans, David M.; Ohlsson, Claes

    2017-01-01

    Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,

  4. Relationship between grip, pinch strengths and anthropometric variables, types of pitch throwing among Japanese high school baseball pitchers.

    Science.gov (United States)

    Tajika, Tsuyoshi; Kobayashi, Tsutomu; Yamamoto, Atsushi; Shitara, Hitoshi; Ichinose, Tsuyoshi; Shimoyama, Daisuke; Okura, Chisa; Kanazawa, Saeko; Nagai, Ayako; Takagishi, Kenji

    2015-03-01

    Grip and pinch strength are crucially important attributes and standard parameters related to the functional integrity of the hand. It seems significant to investigate normative data for grip and pinch strength of baseball players to evaluate their performance and condition. Nevertheless, few reports have explained the association between grip and pinch strength and anthropometric variables and types of pitch throwing for baseball pitchers. The aim of this study was to measure and evaluate clinical normative data for grip and tip, key, palmar pinch strength and to assess the relationship between these data and anthropometric variables and types of pitch throwing among Japanese high-school baseball pitchers. One hundred-thirty three healthy high school baseball pitchers were examined and had completed a self-administered questionnaire including items related to age, hand dominance, throwing ratio of type of pitch. A digital dynamometer was used to measure grip strength and a pinch gauge to measure tip, key and palmer pinch in both dominant and nondominant side. Body composition was measured by the multi frequency segmental body composition analyzer. Grip strength and tip and palmer pinch strength in dominant side were statistically greater than them in nondominant side (P types of pitches thrown and grip strength and tip, key, palmar pinch strength. Our result provides normative values and evidences for grip and pinch strengths in high school baseball pitchers.

  5. Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102

    DEFF Research Database (Denmark)

    Frederiksen, Henrik; Hjelmborg, Jacob; Mortensen, Jakob

    2006-01-01

    with increasing age. Estimates were obtained by using full-information methods from large population-representative studies. Equations of expected grip strength, as well as tables with sex-, age-, and height-stratified reference data, provide an opportunity to include grip-strength measurement in clinical care...

  6. An investigation of the association between grip strength and hip and knee joint moments in older adults.

    Science.gov (United States)

    Samuel, Dinesh; Rowe, Philip

    2012-01-01

    Grip strength is a predictor of health outcomes but with differing rates of age-related decline in muscle strength, it is unclear whether handgrip is a reliable indicator of lower limb moments. This study investigated the relationship between grip strength and lower extremity moments in community-dwelling older adults. Eighty-two healthy volunteers aged 60-82 years (mean age 73.2 years) performed maximal voluntary contractions of knee and hip extensors and flexors at three positions and at neutral position for hip abductors and adductors using a custom-built dynamometer. Grip strength was measured using an electronic Jamar dynamometer. The relative reduction in muscle strength of 80s age category compared to 60-year-olds ranged from 14% for grip strength to 27% for hip abductors. Peak torque of flexors and extensors of the knee and hip joints were significantly correlated with grip strength and Pearson's correlation coefficients ranged from 0.56 to 0.78 with the highest correlations observed between knee moments and grip strength. "Good" correlation was found but only 31-60% of the variation in grip strength could be related to changes in joint torques. Hence the assumption that grip strength is an indicator of strength in the lower limb would seem unjustified in the healthy older adult.

  7. The cost-effectiveness of grip on challenging behaviour: an economic evaluation of a care programme for managing challenging behaviour

    NARCIS (Netherlands)

    Zwijsen, S.A.; Bosmans, J.E.; Gerritsen, D.L.; Pot, A.M.; Hertogh, C.M.; Smalbrugge, M.

    2016-01-01

    OBJECTIVE: The objective of the study was to evaluate the cost-effectiveness of implementing the Grip on Challenging Behaviour care programme (GRIP) on dementia special care units in comparison with usual care. METHODS: A stepped wedge design was used. Challenging behaviour and quality of life were

  8. Influence On Physical Work While Working With Segmental Vibration Inducing Hand Operated Power Tools

    Directory of Open Access Journals (Sweden)

    Sudhir Vinayakrao. Deshmukh

    2012-10-01

    Full Text Available Study evaluates and assesses the work done by vibrating equipments. It includes the assessment of influence of various independent variables associated with hand tools, operators, work & environmental factors on various dependent variables. Three tools selected for study include Rock drill (Dry type (Tool-1, Concrete breaker (Tool-2, Hand grinder (Tool-3. The impact of vibration exposure on health of operators is assessed by the help of survey. It is found that the human energy expenditure is more in the subjects having low grip strength whereas it is less in the subjects of more grip strength. The subjects having more grip strength show less change in touch sensation. The human energy expenditure of subjects of hand grinder is significantly less than the subjects of rock drill and concrete breaker. The presence of hand arm vibration Syndrome (HAVS in the subjects under heavy work, like rock drill and concrete breaker found very high.

  9. Does grip strength on the unaffected side of patients with hemiparetic stroke reflect the strength of other ipsilateral muscles?

    Science.gov (United States)

    Takahashi, Jumpei; Nishiyama, Toru; Matsushima, Yoshimasa

    2017-01-01

    [Purpose] Grip strength is used as an indicator of overall body muscular strength. However, most studies on grip strength have been performed in healthy people, and no study has evaluated it in the unaffected side of patients with hemiparetic stroke. The purpose of this study was to determine if grip strength on the unaffected side of patients with hemiparetic stroke correlates with the strength of other ipsilateral musculature. [Subjects and Methods] The maximal strengths of the muscles on the unaffected side of 31 patients with hemiparetic stroke were measured, and correlation coefficients were calculated. [Results] The results revealed significant positive correlations between grip strength on the unaffected side and the strength of the other ipsilateral muscle groups, with relatively high correlations being observed for the upper extremity muscle groups. [Conclusion] This suggests that grip strength on the unaffected side of patients with hemiparetic stroke can be used as a simple way to estimate overall strength on that side.

  10. Differential roles for NSF and GRIP/ABP in AMPA receptor cycling.

    Science.gov (United States)

    Braithwaite, Steven P; Xia, Houhui; Malenka, Robert C

    2002-05-14

    alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) stability and movement at synapses are important factors controlling synaptic strength. Here, we study the roles of proteins [N-ethylmaleimide-sensitive fusion protein (NSF), glutamate receptor AMPAR binding protein (ABP)-interacting protein (GRIP)/(ABP), and protein interacting with C-kinase-1 (PICK1) that interact with the GluR2 subunit in the control of the surface expression and cycling of AMPARs. Epitope-tagged GluR2 formed functional receptors that exhibited targeting to synaptic sites. Constructs in which binding to NSF, PDZ proteins (GRIP/ABP and PICK1), or GRIP/ABP alone was eliminated each exhibited normal surface targeting and constitutive cycling. The lack of NSF binding, however, resulted in receptors that were endocytosed to a greater extent than wild-type receptors in response to application of AMPA or N-methyl-d-aspartate (NMDA). Conversely, the behavior of the GluR2 mutants incapable of binding to GRIP/ABP suggests that these PDZ proteins play a role in the stabilization of an intracellular pool of AMPARs that have been internalized on stimulation, thus inhibiting their recycling to the synaptic membrane. These results provide further evidence for distinct functional roles of GluR2-interacting proteins in AMPAR trafficking.

  11. Weight-specific anticipatory coding of grip force in human dorsal premotor cortex

    DEFF Research Database (Denmark)

    van Nuenen, Bart F L; Kuhtz-Buschbeck, Johann; Schulz, Christian

    2012-01-01

    ). An additional pre-cue (S1) correctly predicted the weight in 75% of the trials. Participants were asked to use this prior information to prepare for the lift. In the sham condition, grip force showed a consistent undershoot, if the S1 incorrectly prompted the preparation of a light lift. Likewise, an S1...

  12. Eyes, Grip and Gesture as Objective Indicators of Intentions and Attention

    DEFF Research Database (Denmark)

    Mortensen, Ditte Hvas

    This poster abstract presents the first part of a study concerning the use of information about gaze, grip and gesture to create non-command interaction. The experiment reported here seeks to establish the occurrence of patterns in nonverbal communication,  which may be used in an activity aware...

  13. Facilitation of corticospinal tract excitability by transcranial direct current stimulation combined with voluntary grip exercise.

    Science.gov (United States)

    Kim, Gi-Wook; Ko, Myoung-Hwan

    2013-08-26

    Previous studies have established that transcranial direct current stimulation (tDCS) is a powerful technique for the deliberate manipulation of the activity of human cerebral cortex. Moreover, it has also been shown that the non-exhausted voluntary motor exercise increases the excitability of corticospinal tract. We conducted this study to define the facilitation effect following anodal tDCS combined with the voluntary grip exercise as compared with single use of tDCS or voluntary grip exercise. Our result showed that the combination of anodal tDCS with voluntary grip exercise produced a 2-fold increase in the amplitude of MEP as compared with single use of anodal tDCS or voluntary grip exercise. In conclusion, our result could indicate that the treatment outcomes of brain and neurorehabilitation using tDCS would be better when tDCS is combined with the appropriate method of voluntary exercise as compared with single use of tDCS. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  14. Grip Force Control Is Dependent on Task Constraints in Children with and without Developmental Coordination Disorder

    Science.gov (United States)

    Law, Sui-Heung; Lo, Sing Kai; Chow, Susanna; Cheing, Gladys L.Y.

    2011-01-01

    Excessive grip force (GF) is often found in children with developmental coordination disorder (DCD). However, their GF control may vary when task constraints are imposed upon their motor performance. This study aimed to investigate how their GF control changes in response to task demands, and to examine their tactile sensitivity. Twenty-one…

  15. EFFECT OF ECCENTRIC EXERCISE PROGRAMME ON PAIN AND GRIP STRENGTH FOR SUBJECTS WITH MEDIAL EPICONDYLITIS

    Directory of Open Access Journals (Sweden)

    Mishra Prashant Akhilesh

    2014-04-01

    Full Text Available Background and Objective: Therapeutic eccentric exercise may provide both a structural and functional benefit during tendinopathy rehabilitation. The objective is to find the effect of eccentric exercises on improvement of pain and grip strength for subjects with Medial Epicondylitis. Method: Pre to post test experimental study design randomized thirty subjects with medial epicondylitis, 15 each into Group A and Group B. Group B subjects were treated with conventional therapy and Eccentric exercises. Group A subjects were treated with conventional therapy. Results: When means of post intervention were compared using Independent ‘t’ between groups there was no statistically significant difference in improvements obtained in VAS scores and grip strength. There was a statistically significant change in means of VAS score and Grip strength when means were analyzed by using Paired‘t’ test and Wilcoxon signed rank test within the groups with positive percentage of change. Conclusion: It is concluded that four weeks of Eccentric Exercise Programme combined with conventional therapy shown significant effect on improving pain and Grip strength, however the improvement obtained has no difference when compared with control conventional treatment for Subjects with Medial Epicondylitis.

  16. The effect of precision and power grips on activations in human auditory cortex

    Directory of Open Access Journals (Sweden)

    Patrik Alexander Wikman

    2015-10-01

    Full Text Available The neuroanatomical pathways interconnecting auditory and motor cortices play a key role in current models of human auditory cortex (AC. Evidently, auditory-motor interaction is important in speech and music production, but the significance of these cortical pathways in other auditory processing is not well known. We investigated the general effects of motor responding on AC activations to sounds during auditory and visual tasks. During all task blocks, subjects detected targets in the designated modality, reported the relative number of targets at the end of the block, and ignored the stimuli presented in the opposite modality. In each block, they were also instructed to respond to targets either using a precision grip, power grip, or to give no overt target responses. We found that motor responding strongly modulated AC activations. First, during both visual and auditory tasks, activations in widespread regions of AC decreased when subjects made precision and power grip responses to targets. Second, activations in AC were modulated by grip type during the auditory but not during the visual task. Further, the motor effects were distinct from the strong attention-related modulations in AC. These results are consistent with the idea that operations in AC are shaped by its connections with motor cortical regions.

  17. Precision grip in congenital and acquired hemiparesis: similarities in impairments and implications for neurorehabilitation - review

    Directory of Open Access Journals (Sweden)

    Yannick eBleyenheuft

    2014-06-01

    Full Text Available Background: Patients with congenital and acquired hemiparesis incur long-term functional deficits, among which the loss of prehension that may impact their functional independence. Identifying, understanding and comparing the underlying mechanisms of prehension impairments represent an opportunity to better adapt neurorehabilitationObjective: The present review aims to provide a better understanding of precision grip deficits in congenital and acquired hemiparesis and to determine whether the severity and type of fine motor control impairments depend on whether or not the lesions are congenital or acquired in adulthood. Methods: Using combinations of the following key words: fingertip force, grip force, precision grip, cerebral palsy, stroke, pubmed and Scopus databases were used to search studies from 1984 to 2013. Results: Individuals with both congenital and acquired hemiparesis were able to some extent to use anticipatory motor control in precision grip tasks, even if this control was impaired in the paretic hand. In both congenital or acquired hemiparesis, the ability to plan efficient anticipatory motor control when the less-affected hand is used provides a possibility to remediate impairments in anticipatory motor control of the paretic hand. Conclusion: Surprisingly we observed very few differences between the results of studies in children with congenital hemiplegia and stroke patients. We suggest that the underlying specific strategies of neurorehabilitation developed for each one could benefit the other.

  18. Getting a grip on numbers : Numerical magnitude priming in object grasping

    NARCIS (Netherlands)

    Lindemann, Oliver; Abolafia, Juan A.; Girardi, Giovanna; Bekkering, Harold

    2007-01-01

    To investigate the functional connection between numerical cognition and action planning, the authors required participants to perform different grasping responses depending on the parity status of Arabic digits. The results show that precision grip actions were initiated faster in response to small

  19. Frimand Needle Holder Reduces Suturing Time and Surgical Stress When Suturing in Palm Grip.

    Science.gov (United States)

    Frimand Rönnow, Carl-Fredrik; Jeppsson, Bengt; Thorlacius, Henrik

    2016-06-01

    Purpose The Frimand needle holder (FNH) was developed to facilitate palm grip suturing. In the present study, we wanted to examine the impact of the FNH compared with a conventional Hegar-styled needle holder (HSNH) on suture time and surgical stress. Methods Thirty-two surgeons were enrolled and they performed sets of 3 continuous sutures on a polyurethane pad with premarked insert and exit points and the time for suturing was measured. Surgical stress was quantified by having the surgeons to perform 10 release maneuvers with the FNH and the HSNH on a needle attached to a scale. The scale sent 5 values per second to a computer. The first measurement of each series was regarded as the starting weight and all subsequent measurements were either regarded as neutral, pressure or traction. The sum of these measurements represented total surgical stress. Results We found that all surgeons reduced their median suturing time by 16% when using FNH for palm grip suturing with no difference between junior and senior surgeons. Moreover, it was observed that FNH decreased median surgical stress by 62% for all surgeons performing palm grip suturing compared with a conventional HSNH. Conclusion We conclude that the FNH reduces suture time and surgical stress compared with HSNH when performing palm grip suturing. These findings warrant studies in surgical patients in order to evaluate the potential clinical impact of FNH.

  20. First flight of the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) instrument

    CERN Document Server

    Duncan, Nicole; Shih, A Y; Hurford, G J; Bain, H M; Amman, M; Mochizuki, B A; Hoberman, J; Olson, J; Maruca, B A; Godbole, N M; Smith, D M; Sample, J; Kelley, N A; Zoglauer, A; Caspi, A; Kaufmann, P; Boggs, S; Lin, R P

    2016-01-01

    The Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) is a balloon-borne telescope designed to study solar-flare particle acceleration and transport. We describe GRIPS's first Antarctic long-duration flight in Jan 2016 and report preliminary calibration and science results. Electron and ion dynamics, particle abundances and the ambient plasma conditions in solar flares can be understood by examining hard X-ray (HXR) and gamma-ray emission (20 keV to 10 MeV) with enhanced imaging, spectroscopy and polarimetry. GRIPS is specifically designed to answer questions including: What causes the spatial separation between energetic electrons producing HXRs and energetic ions producing gamma-ray lines? How anisotropic are the relativistic electrons, and why can they dominate in the corona? How do the compositions of accelerated and ambient material vary with space and time, and why? GRIPS's key technological improvements over the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) include 3D position-sensi...

  1. Grip Strength as a Marker of Hypertension and Diabetes in Healthy Weight Adults.

    Science.gov (United States)

    Mainous, Arch G; Tanner, Rebecca J; Anton, Stephen D; Jo, Ara

    2015-12-01

    Muscle strength may play a role in cardiometabolic disease. We examined the relationship between hand grip strength and diabetes and hypertension in a sample of healthy weight adults. In 2015, we analyzed the National Health and Nutrition Examination Survey 2011-2012 for adults aged ≥20 years with healthy BMIs (between 18.5 and Hypertension was based on measured blood pressure and reported hypertension diagnosis. Individuals with undiagnosed diabetes compared with individuals without diabetes had lower grip strength (51.9 vs 69.8, p=0.0001), as did individuals with diagnosed diabetes compared with individuals without diabetes (61.7 vs 69.8, p=0.008). Mean grip strength was lower among individuals with undiagnosed hypertension compared with individuals without hypertension (63.5 vs 71.5, p=0.008) as well as among individuals with diagnosed hypertension compared with those without hypertension (60.8 vs 71.5, phypertension (β=-6.6, p=0.004) and diagnosed hypertension (β=-4.27, p=0.04) compared with individuals without hypertension. Among healthy weight adults, combined grip strength is lower in individuals with diagnosed and undiagnosed diabetes and hypertension. Copyright © 2015 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  2. Measurement error in grip and pinch force measurements in patients with hand injuries.

    Science.gov (United States)

    Schreuders, Ton A R; Roebroeck, Marij E; Goumans, Janine; van Nieuwenhuijzen, Johan F; Stijnen, Theo H; Stam, Henk J

    2003-09-01

    There is limited documentation of measurement error of grip and pinch force evaluation methods. The purposes of this study were (1) to determine indexes of measurement error for intraexaminer and interexaminer measurements of grip and pinch force in patients with hand injuries and (2) to investigate whether the measurement error differs between measurements of the injured and noninjured hands and between experienced and inexperienced examiners. The subjects were a consecutive sample of 33 patients with hand injuries who were seen in the Department of Rehabilitation Medicine of Erasmus MC-University Medical Center Rotterdam in the Netherlands. Repeated measurements were taken of grip and pinch force, with a short break of 2 to 3 minutes between sessions. For the grip force in 2 handle positions (distance between handles of 4.6 and 7.2 cm, respectively), tip pinch (with the index finger on top and the thumb below, with the other fingers flexed) and key pinch force (with the thumb on top and the radial side of the index finger below) data were obtained on both hands of the subjects by an experienced examiner and an inexperienced examiner. Intraclass correlation coefficients (ICCs), standard errors of measurement (SEMs), and associated smallest detectable differences (SDDs) were calculated and compared with data from previous studies. The reliability of the measurements was expressed by ICCs between .82 and .97. For grip force measurements (in the second handle position) by the experienced examiner, an SDD of 61 N was found. For tip pinch and key pinch, these values were 12 N and 11 N, respectively. For measurements by the inexperienced examiner, SDDs of 56 N for grip force and 13 N and 18 N for tip pinch and key pinch were found. Based on the SEMs and SDDs, in individual patients only relatively large differences in grip and pinch force measurements can be adequately detected between consecutive measurements. Measurement error did not differ between injured and

  3. Effects of Taping on Pain, Grip Strength and Wrist Extension Force in Patients with Tennis Elbow

    Directory of Open Access Journals (Sweden)

    Alireza Shamsoddini

    2013-09-01

    Full Text Available Background: Tennis elbow (TE is a common musculotendinous degenerative disorder of the extensor origin at the lateral humeral epicondyle. Different modes of treatment are used for management of tennis elbow.Objectives: This study investigated the effect of the taping technique (TT on pain, grip strength and wrist extension force in treatment of tennis elbow.Patients and Methods: Thirty patients (16 men /14 women with a mean age of 32.2 years with tennis elbow of their dominant arm participated in this study. Outcome measures were assessment of pain at the lateral aspect of the elbow, grip strength and wrist extension force before and five to ten minutes after application of elbow tape on the affected and unaffected arms. A Visual Analog Scale was used to assess pain. A dynamometer and a hand-held dynamometer were used for evaluation of grip strength and wrist extension force, respectively.Results: Among the variables, significant differences were found in wrist extension forces between effected and unaffected arms (P = 0.02. Changes in grip strength showed statically significant improvements in the affected arm compared to the unaffected arm (P = 0.03. Also, in assessment of pain at the lateral epicondyle, the mean change between affected and unaffected arms was significant, with P = 0.001.Conclusions: The taping technique, as applied in this study demonstrates an impressive effect on wrist extension force and grip strength of patients with TE. Elbow taping also reduces pain at the lateral aspect of the elbow in these patients.

  4. Enhanced independence: experiences after regaining grip function in people with tetraplegia.

    Science.gov (United States)

    Wangdell, Johanna; Carlsson, Gunnel; Fridén, Jan

    2013-01-01

    To explore how surgical reconstruction of grip affects everyday life for patients with tetraplegia, with special emphasis on patients perspective of their perceived changes. Qualitative method. Eleven people (aged 22-73) with tetraplegia who had undergone surgical reconstruction to restore grip function. Qualitative interviews were conducted 7-17 months after surgery and analysed using Grounded theory. The core concept describing the participants experienced gains after grip reconstructive surgery was "enhanced independence". It was associated with changes in both practical and psychological aspects of independence. Practical aspects identified were: "perform more activities", "smoother everyday life", "renewed ability to participate in social activities", "less dependence on assistance" and "less restricted by physical environment". Psychological aspects of independence included "regained privacy", "increased manageability", "regained identity", "recapture a part of the body" and "share positive experiences with relatives and friends". Encompassing all categories was the concept "self-efficacy in hand control". It was seen as a result included in the enhanced independency core but also as an important factor for the development of all the other categories. Participants in this study experienced enhanced independence after grip reconstructive surgery and rehabilitation. The enhanced independence included both practical and physical aspects and it influenced all domains using the International Classification of Function, Disability and Health model; body function and structure, activities, participation, personal factors and environmental factors. Implications for Rehabilitation Patients with tetraplegia experience grip reconstruction as a useful intervention, an enhanced independence, related to their improved hand control. The increased hand control impacted not only physical aspects but also practical and psychological aspects. It also influenced social and

  5. Hand grip strength and chronic obstructive pulmonary disease in Korea: an analysis in KNHANES VI

    Directory of Open Access Journals (Sweden)

    Lee SH

    2017-08-01

    Full Text Available Su Hwan Lee, Soo Jung Kim, Yeji Han, Yon Ju Ryu, Jin Hwa Lee, Jung Hyun Chang Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea Background: Muscle mass is known to be associated with mortality in elderly adults. Because hand grip strength (HGS is known as a simple assessment tool for muscular strength, many researchers have studied the association between HGS and disease. However, empirical evidence for the relationship between chronic obstructive pulmonary disease (COPD and HGS is still controversial. The aim of this study was to evaluate the association between COPD and HGS, using Korean population data. Methods: This was a population-based cross-sectional study. Data were obtained from the sixth Korean National Health and Nutrition Examination Survey, which was conducted from 2013 to 2015. To reduce the effects of HGS-related factors and potential confounding factors, propensity score matching was used to match subjects with and without COPD. Results: Among 14,930 subjects, 832 were enrolled in each group (non-COPD and COPD after propensity score matching. COPD subjects did not have lower HGS than non-COPD subjects (non-COPD vs COPD, male, 38.0±7.0 vs 38.9±7.0 kg, P=0.044, female, 23.8±4.6 vs 24.2±4.9 kg, P=0.342. Lung function was classified by Global Initiative for Chronic Obstructive Lung Disease stages and was not significantly associated with HGS. For male COPD subjects, there was a significant correlation between HGS and the EuroQol Five-Dimension Questionnaire (EQ5D utility score index, which is an indicator of quality of life that adjusts for age and body mass index (r=0.201, P<0.001. The correlation was absent for female subjects (r=0.098, P=0.170. Conclusion: COPD subjects did not have lower HGS than non-COPD subjects. HGS did not associate with lung function. However, the HGS of male COPD subjects was

  6. Analysis of the statistical methods used to detect submaximal effort with the five-rung grip strength test.

    Science.gov (United States)

    Shechtman, Orit; Gutierrez, Zeida; Kokendofer, Emily

    2005-01-01

    Controversy exists in the literature concerning the ability of the five-rung grip test to identify submaximal effort. The purpose of this study was to analyze four methods commonly used to evaluate the shape of the curve generated by maximal versus submaximal efforts. Thirty hand therapy patients performed the five-rung grip test maximally and submaximally with both their injured and uninjured hands. Grip strength scores were recorded at each of the five-rung positions. Next, four methods were used to analyze the data 1) visual analysis, 2) analysis of variance, 3) normalization, and 4) calculation of the standard deviation across the five strength scores. Analysis by all methods demonstrated that there were no differences between the injured hand exerting maximal effort and the uninjured hand exerting submaximal effort. In all four methods, the five-rung grip strength test was unable to distinguish between the injured hand exerting maximal effort and the uninjured hand exerting submaximal effort. The results suggest that the five-rung grip strength test should not be used to determine sincerity of effort in people with hand injuries, and that the shape of the curve generated by the five-rung grip strength test may not be related to level of effort but rather to the amount of force generated by the gripping hand.

  7. First flight of the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) instrument

    Science.gov (United States)

    Duncan, Nicole; Saint-Hilaire, P.; Shih, A. Y.; Hurford, G. J.; Bain, H. M.; Amman, M.; Mochizuki, B. A.; Hoberman, J.; Olson, J.; Maruca, B. A.; Godbole, N. M.; Smith, D. M.; Sample, J.; Kelley, N. A.; Zoglauer, A.; Caspi, A.; Kaufmann, P.; Boggs, S.; Lin, R. P.

    2016-07-01

    The Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) instrument is a balloon-borne telescope designed to study solar- are particle acceleration and transport. We describe GRIPS's first Antarctic long-duration flight in January 2016 and report preliminary calibration and science results. Electron and ion dynamics, particle abundances and the ambient plasma conditions in solar flares can be understood by examining hard X-ray (HXR) and gamma-ray emission (20 keV to 10 MeV). Enhanced imaging, spectroscopy and polarimetry of are emissions in this energy range are needed to study particle acceleration and transport questions. The GRIPS instrument is specifically designed to answer questions including: What causes the spatial separation between energetic electrons producing hard X-rays and energetic ions producing gamma-ray lines? How anisotropic are the relativistic electrons, and why can they dominate in the corona? How do the compositions of accelerated and ambient material vary with space and time, and why? GRIPS's key technological improvements over the current solar state of the art at HXR/gamma-ray energies, the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI), include 3D position-sensitive germanium detectors (3D-GeDs) and a single-grid modulation collimator, the multi-pitch rotating modulator (MPRM). The 3D-GeDs have spectral FWHM resolution of a few hundred keV and spatial resolution 150 keV, the energy deposition sites can be tracked, providing polarization measurements as well as enhanced background reduction through Compton imaging. Each of GRIPS's detectors has 298 electrode strips read out with ASIC/FPGA electronics. In GRIPS's energy range, indirect imaging methods provide higher resolution than focusing optics or Compton imaging techniques. The MPRM gridimaging system has a single-grid design which provides twice the throughput of a bi-grid imaging system like RHESSI. The grid is composed of 2.5 cm deep tungsten-copper slats, and quasi

  8. Organism versus mechanism: Losing our grip on the distinction

    Directory of Open Access Journals (Sweden)

    Henk Reitsema

    2013-11-01

    Full Text Available The distinction between organism and mechanism is often subtle or unclear and yet can prove to be fundamental to our understanding of the world. It has been tempting for many thinkers to seek to ‘understand’ all of reality through the lens of either the one or the other of these concepts rather than by giving both a place. This article sets out to argue that there is a substantial loss of understanding when either of these metaphors is absolutised to explain all causal processes and patterns in reality. Clarifying the distinction between the two may provide one more tool to grasp what is reductionist in many of the perspectives that have come to dominate public life and science today. This contention is tested on the quest for the design of self-replicating systems (i.e. synthetic organisms in the nanotech industry. It is common that the concepts of organic functioning and mechanism are used imprecisely and in an overlapping way. This is also true of much scientific debate, especially in the fields of biology, micro-biology and nano-science. This imprecise use signals a reductionist tendency both in the way that the organic is perceived and in terms of the distinctive nature of mechanisms.

  9. A Monte Carlo-tuned model of the flow in the NorthGRIP area

    DEFF Research Database (Denmark)

    Grinsted, Aslak; Dahl-Jensen, Dorthe

    2002-01-01

    The North Greenland Icecore Project (NorthGRIP) drill site was chosen in order to obtain a good Eemian record. At the present depth, 3001m, the Eemian interstadial has yet to be seen. Clearly the flow in this area is poorly understood and needs further investigation. After a review of specific...... no Eemian is observed is a high basal melt rate (2.7mm/a). The melting is a consequence of a higher geothermal heat flux than the expected 51mW/m^2 of the Precambrian shield. From our analyses it is concluded that the geothermal heat flux at NorthGRIP is 98mW/m^2.The high basalmelt rate also gives rise...

  10. Dynamics of Crystal Formation in the Greenland NorthGRIP Ice Core

    CERN Document Server

    Mathiesen, J; Jensen, M H; Levinsen, M; Olesen, P; Dahl-Jensen, D; Svensson, A; Mathiesen, Joachim; Ferkinghoff-Borg, Jesper; Jensen, Mogens H.; Levinsen, Mogens; Olesen, Poul; Dahl-Jensen, Dorthe; Svensson, Anders

    2003-01-01

    The North Greenland Ice Core Project (NorthGRIP) provides paleoclimatic information back to at least 115 kyr before present [Dahl-Jensen et al., 2002]. Each year, precipitation on the ice sheet covers it with a new layer of snow, which gradually transforms into ice crystals as the layer sinks into the ice sheet. The size distribution of ice crystals has been measured at selected depths in the upper 880 m of the NorthGRIP ice core [Svensson et al., 2003b], which cover a time span of 5300 years. The distributions change with time toward a universal curve, indicating a common underlying physical process in the formation of crystals. We identify this process as an interplay between fragmentation of the crystals and diffusion of their grain boundaries. The process is described by a two-parameter differential equation to which we obtain the exact solution. The solution is in excellent agreement with the experimentally observed distributions.

  11. Randomized clinical trial of self-gripping mesh versus sutured mesh for Lichtenstein hernia repair

    DEFF Research Database (Denmark)

    Jorgensen, L N; Sommer, T; Assaadzadeh, S;

    2012-01-01

    between the groups in postoperative complications (33·7 versus 40·4 per cent; P = 0·215), rate of recurrent hernia within 1 year (1·2 per cent in both groups) or quality of life. CONCLUSION: The avoidance of suture fixation using a self-gripping mesh was not accompanied by a reduction in chronic symptoms......BACKGROUND: Many patients develop discomfort after open repair of a groin hernia. It was hypothesized that suture fixation of the mesh is a cause of these symptoms. METHODS: This patient- and assessor-blinded randomized multicentre clinical trial compared a self-gripping mesh (Parietene Progrip......(®) ) and sutured mesh for open primary repair of uncomplicated inguinal hernia by the Lichtenstein technique. Patients were assessed before surgery, on the day of operation, and at 1 and 12 months after surgery. The primary endpoint was moderate or severe symptoms after 12 months, including a combination...

  12. First flight of the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS)

    Science.gov (United States)

    Saint-Hilaire, Pascal; Shih, Albert Y.; Duncan, Nicole; Bain, Hazel; Maruca, Bennett A.; Kelley, Nicole; Godbole, Niharika; Kaufmann, Pierre; Caspi, Amir; Sample, John; Hoberman, Jane; Mochizuki, Brent; Olson, Jerry; Boggs, Steven E.; Zoglauer, Andreas; Hurford, Gordon J.; Smith, David M.; Tajima, Hiroyasu; Amman, Mark

    2016-05-01

    The Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) high altitude balloon payload was successfully flown in January 2016 from Antarctica (Jan 19 to Jan 30).GRIPS provides a near-optimal combination of high-resolution imaging, spectroscopy, and polarimetry of solar-flare gamma ray/hard X-ray emissions from ~20 keV to >~10 MeV. GRIPS’s goal is to address questions raised by recent solar flare observations regarding particle acceleration and energy release, such as: What causes the spatial separation between energetic electrons producing hard X-rays and energetic ions producing gamma-ray lines? How anisotropic are the relativistic electrons, and why can they dominate in the corona? How do the compositions of accelerated and ambient material vary with space and time, and why? The spectrometer/polarimeter consists of six 3D position-sensitive germanium detectors (3D-GeDs), where each energy deposition is individually recorded with an energy resolution of a few keV FWHM and a spatial resolution gamma-ray energies (12.5 arcsec FWHM), sufficient to separate 2.2 MeV footpoint sources for almost all flares. Polarimetry is accomplished by analyzing the anisotropy of reconstructed Compton scattering in the 3D-GeDs, with an estimated minimum detectable polarization of a few percent at 150-650 keV in an X-class flare. GRIPS was also equipped with active BGO shields, and three piggy-back instruments: a solar terahertz radiometer (Solar-T), a hard X-ray spectrometer (SMASH), and a sonic anemometer (TILDAE).We will present an overview of GRIPS's first flight, the performance of its instruments and subsystems, including the solar pointing and aspect systems, and the current progress of our data analysis.

  13. Relation between hand grip strength, respiratory muscle strength and spirometric measures in male nursing home residents.

    Science.gov (United States)

    Bahat, Gulistan; Tufan, Asli; Ozkaya, Hilal; Tufan, Fatih; Akpinar, Timur Selçuk; Akin, Sibel; Bahat, Zumrut; Kaya, Zuleyha; Kiyan, Esen; Erten, Nilgün; Karan, Mehmet Akif

    2014-09-01

    Adverse-outcomes related to sarcopenia are mostly mentioned as physical disability. As the other skeletal muscles, respiratory muscles may also be affected by sarcopenia. Respiratory muscle strength is known to affect pulmonary functions. Therefore, we aimed to investigate the relations between extremity muscle strength, respiratory muscle strengths and spirometric measures in a group of male nursing home residents. Among a total of 104 male residents, residents with obstructive measures were excluded and final study population was composed of 62 residents. Mean age was 70.5 ± 6.7 years, body mass index: 27.7 ± 5.3 kg/m2 and dominant hand grip strength: 29.7 ± 6.5 kg. Hand grip strength was positively correlated with maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) (r = 0.35, p strength; among spirometric measures only parameter significantly related to grip strength was peak cough flow (PCF). The association of PCF with grip strength disappeared when MIP alone or "MIP and MEP" were included in the regression analysis. In the latter case, PCF was significantly associated only with MIP. We found peripheric muscle strength be associated with MIP and PCF but not with MEP or any other spirometric parameters. The relation between peripheral muscle strength and PCF was mediated by MIP. Our findings suggest that sarcopenia may affect inspiratory muscle strength earlier or more than the expiratory muscle strength. Sarcopenia may cause decrease in PCF in the elderly, which may stand for some common adverse respiratory complications.

  14. Tension free open inguinal hernia repair using an innovative self gripping semi-resorbable mesh

    Directory of Open Access Journals (Sweden)

    Chastan Philippe

    2006-01-01

    Full Text Available Aims: Inguinal hernia repair according to Lichtenstein technique has become the most common procedure performed by general surgeons. Heavy weight polypropylene meshes have been reported to stimulate inflammatory reaction responsible for mesh shrinkage when scar tissue evolved. Additionally, some concerns remain regarding the relationship between chronic pain and mesh fixation technique. In order to reduce those drawbacks, we have developed a new mesh for anterior tension free inguinal hernia repair which exhibits self-gripping absorbable properties. Materials and Methods: 52 patients (69 hernias were prospectivly operated with this mesh (SOFRADIM-France made of low-weight isoelastic large pores knitted fabric which incorporated resorbable micro hooks that provides self gripping properties to the mesh during the first months post-implantation. The fixation of the mesh onto the tissues is significantly facilitated. The mesh is secured around the cord with a self gripping flap. After complete tissular ingrowth and resorption of the PLA hooks, the low-weight (40 g/m2 polypropylene mesh insures the long term wall reinforcement. Results: Peroperativly, no complication was reported, the mesh was easy to handle and to fix. Discharge was obtained at Day 1. No perioperative complication occurred, return to daily activities was obtained at Day 5.5. At one month, no neurological pain or other complications were described. Conclusions: Based on the first results of this clinical study, this unique concept of low density self gripping mesh should allows an efficient treatment of inguinal hernia. It should reduce postoperative complications and the extent of required suture fixation, making the procedure more reproducible

  15. Interobserver reproducibility of the assessment of severity of complaints, grip strength, and pressure pain threshold in patients with lateral epicondylitis.

    NARCIS (Netherlands)

    Smidt, N.; Windt, A. van der; Assendelft, W.J.; Mourits, A.J.; Devillé, W.L.; Winter, F. de; Bouter, L.M.

    2002-01-01

    Objective: To evaluate the interobserver reproducibility of the assessment of severity of complaints, grip strength, and pressure pain threshold in patients with lateral epicondylitis in primary care. Design: Two physiotherapists assessed independently, and in randomized order, the severity of

  16. Interobserver reproducibility of the assessment of severity of complaints, grip strength, and pressure pain threshold in patients with lateral epicondylitis

    NARCIS (Netherlands)

    Smidt, N; van der Windt, DA; Assendelft, WJ; Mourits, AJ; Deville, WL; de Winter, AF; Bouter, LM

    2002-01-01

    Objective: To evaluate the interobserver reproducibility of the assessment of severity of complaints, grip strength, and pressure pain threshold in patients with lateral epicondylitis in primary care. Design: Two physiotherapists assessed independently, and in randomized order, the severity of compl

  17. Interobserver reproducibility of the assessment of severity of complaints, grip strength, and pressure pain threshold in patients with lateral epicondylitis.

    NARCIS (Netherlands)

    Smidt, N.; Windt, A. van der; Assendelft, W.J.; Mourits, A.J.; Devillé, W.L.; Winter, F. de; Bouter, L.M.

    2002-01-01

    Objective: To evaluate the interobserver reproducibility of the assessment of severity of complaints, grip strength, and pressure pain threshold in patients with lateral epicondylitis in primary care. Design: Two physiotherapists assessed independently, and in randomized order, the severity of compl

  18. Role of movement velocity on the magnitude of grip force while lifting an object with touch from the contralateral finger.

    Science.gov (United States)

    Iyengar, Veena; Santos, Marcio J; Aruin, Alexander S

    2009-04-01

    We investigated whether slower velocity of arm movement affects grip-force generation in conditions with the finger touch provided to the wrist of the target arm. Nine subjects performed the task of lifting and transporting an object at slow, intermediate, and fast velocities with a light finger touch from the contralateral arm and without it. There was an effect of velocity of arm movement on grip-force generation in both conditions. However, when the no touch and touch trials performed with similar velocity were matched, the effect of touch on grip-force reduction was statistically significant (p touch conditions and underlines the importance of using a contralateral touch in the performance of activities of daily living. It also points to a possibility of the development of therapeutic advances for the enhancement of grip-force control in patients with neurological impairments.

  19. Nutritional status is the major factor affecting grip strength of African HIV patients before and during antiretroviral treatment

    DEFF Research Database (Denmark)

    Filteau, Suzanne; PrayGod, G; Woodd, Susannah L

    2017-01-01

    involved HIV-infected Zambian and Tanzanian participants recruited to the NUSTART trial when malnourished (body mass index requiring ART. The relationship of grip strength to nutritional, infectious and demographic factors was assessed by multivariable linear regression at referral...

  20. Flash Detection Efficiencies of Long Range Lightning Detection Networks During GRIP

    Science.gov (United States)

    Mach, Douglas M.; Bateman, Monte G.; Blakeslee, Richard J.

    2012-01-01

    We flew our Lightning Instrument Package (LIP) on the NASA Global Hawk as a part of the Genesis and Rapid Intensification Processes (GRIP) field program. The GRIP program was a NASA Earth science field experiment during the months of August and September, 2010. During the program, the LIP detected lighting from 48 of the 213 of the storms overflown by the Global Hawk. The time and location of tagged LIP flashes can be used as a "ground truth" dataset for checking the detection efficiency of the various long or extended range ground-based lightning detection systems available during the GRIP program. The systems analyzed included Vaisala Long Range (LR), Vaisala GLD360, the World Wide Lightning Location Network (WWLLN), and the Earth Networks Total Lightning Network (ENTLN). The long term goal of our research is to help understand the advantages and limitations of these systems so that we can utilize them for both proxy data applications and cross sensor validation of the GOES-R Geostationary Lightning Mapper (GLM) sensor when it is launched in the 2015 timeframe.

  1. Cortical activation during power grip task with pneumatic pressure gauge: an fMRI study

    Science.gov (United States)

    Mohamad, M.; Mardan, N. H.; Ismail, S. S.

    2017-05-01

    Aging is associated with a decline in cognitive and motor function. But, the relationships with motor performance are less well understood. In this study, functional magnetic resonance imaging (fMRI) was used to assess cortical activation in older adults. This study employed power grip task that utilised block paradigm consisted of alternate 30s rest and active. A visual cue was used to pace the hand grip movement that clenched a cylindrical rubber bulb connected with pressure pneumatic gauge that measure the pressure (Psi). The objective of this study is determined the brain areas activated during motor task and the correlation between percentage signal change of each motor area (BA 4 and 6) and hand grip pressure. Result showed there was a significant difference in mean percentage signal change in BA 4 and BA 6 in both hemispheres and negative correlation obtained in BA 4 and BA 6. These results indicate that a reduced ability in the motor networks contribute to age-related decline in motor performance.

  2. The use of clamping grips and friction pads by tree frogs for climbing curved surfaces

    Science.gov (United States)

    Ji, Aihong; Yuan, Shanshan; Hill, Iain; Wang, Huan; Barnes, W. Jon P.; Dai, Zhendong; Sitti, Metin

    2017-01-01

    Most studies on the adhesive mechanisms of climbing animals have addressed attachment against flat surfaces, yet many animals can climb highly curved surfaces, like twigs and small branches. Here we investigated whether tree frogs use a clamping grip by recording the ground reaction forces on a cylindrical object with either a smooth or anti-adhesive, rough surface. Furthermore, we measured the contact area of fore and hindlimbs against differently sized transparent cylinders and the forces of individual pads and subarticular tubercles in restrained animals. Our study revealed that frogs use friction and normal forces of roughly a similar magnitude for holding on to cylindrical objects. When challenged with climbing a non-adhesive surface, the compressive forces between opposite legs nearly doubled, indicating a stronger clamping grip. In contrast to climbing flat surfaces, frogs increased the contact area on all limbs by engaging not just adhesive pads but also subarticular tubercles on curved surfaces. Our force measurements showed that tubercles can withstand larger shear stresses than pads. SEM images of tubercles revealed a similar structure to that of toe pads including the presence of nanopillars, though channels surrounding epithelial cells were less pronounced. The tubercles' smaller size, proximal location on the toes and shallow cells make them probably less prone to buckling and thus ideal for gripping curved surfaces. PMID:28228509

  3. On the Effect of Different Grips of Handsets on Data Rate in the Measured Channels

    Directory of Open Access Journals (Sweden)

    Maryam Rahimi

    2015-01-01

    Full Text Available The investigation on the achieved data rate of the cellular system considering different grips of handsets at different frequencies using measurement results of the measurement campaign—which was carried out in the city of Aalborg—is presented in this paper. The achieved data rate of the multiple-input single-output (MISO interference channel is investigated. A typical propagation environment using two BSs and four handsets, like smart phones, held by four to eight different users was designed and multiple-input multiple-output (MIMO channels in different scenarios were measured. In this paper, two BSs and two handsets at each measurement time are considered. The impact of the different parameters like correlation, different grips of handsets, and different long term evolution (LTE frequency bands on the achieved data rate is investigated for different measurements. It could be concluded that the variations in the values of data rate are weakly associated with the different grips of handsets but more correlated with different frequencies.

  4. Design and implementation of GRIP: a computerized glucose control system at a surgical intensive care unit

    Directory of Open Access Journals (Sweden)

    Zijlstra Felix

    2005-12-01

    Full Text Available Abstract Background Tight glucose control by intensive insulin therapy has become a key part of critical care and is an important field of study in acute coronary care. A balance has to be found between frequency of measurements and the risk of hypoglycemia. Current nurse-driven protocols are paper-based and, therefore, rely on simple rules. For safety and efficiency a computer decision support system that employs complex logic may be superior to paper protocols. Methods We designed and implemented GRIP, a stand-alone Java computer program. Our implementation of GRIP will be released as free software. Blood glucose values measured by a point-of-care analyzer were automatically retrieved from the central laboratory database. Additional clinical information was asked from the nurse and the program subsequently advised a new insulin pump rate and glucose sampling interval. Results Implementation of the computer program was uneventful and successful. GRIP treated 179 patients for a total of 957 patient-days. Severe hypoglycemia ( Conclusion A computer driven protocol is a safe and effective means of glucose control at a surgical ICU. Future improvements in the recommendation algorithm may further improve safety and efficiency.

  5. Nutritional status is the major factor affecting grip strength of African HIV patients before and during antiretroviral treatment.

    Science.gov (United States)

    Filteau, S; PrayGod, G; Woodd, S L; Friis, H; Heimburger, D C; Koethe, J R; Kelly, P; Kasonka, L; Rehman, A M

    2017-10-01

    Low grip strength is a marker of frailty and a risk factor for mortality among HIV patients and other populations. We investigated factors associated with grip strength in malnourished HIV patients at referral to ART, and at 12 weeks and 2-3 years after starting ART. The study involved HIV-infected Zambian and Tanzanian participants recruited to the NUSTART trial when malnourished (body mass index <18.5 kg/m(2) ) and requiring ART. The relationship of grip strength to nutritional, infectious and demographic factors was assessed by multivariable linear regression at referral for ART (n = 1742) and after 12 weeks (n = 778) and 2-3 years of ART (n = 273). In analyses controlled only for sex, age and height, most nutrition and infection-related variables were associated with grip strength. However, in multivariable analyses, consistent associations were seen for fat-free mass index, mid-upper arm circumference, haemoglobin and systolic blood pressure, and a variable association with fat mass index in men. C-reactive protein and CD4 count had limited independent effects on grip strength, while receiving tuberculosis treatment was associated with weaker grip strength. In this population of originally malnourished HIV patients, poor grip strength was more strongly and independently associated with nutritional than with infection and inflammation variables. Programmes to improve health and survival of HIV patients should incorporate nutritional assessment and management and could use grip strength as a functional indicator of improving nutrition. © 2017 John Wiley & Sons Ltd.

  6. Stress examination of flexor tendon pulley rupture in the crimp grip position: a 1.5-Tesla MRI cadaver study

    Energy Technology Data Exchange (ETDEWEB)

    Bayer, Thomas; Janka, Rolf [University of Erlangen-Nuremberg, Department of Radiology, Erlangen (Germany); Fries, Simon [Cantonal Hospital Lucerne, Orthopaedic Department, Wolhusen (Switzerland); Schweizer, Andreas [University of Zurich, Department of Orthopaedics, Balgrist, Zurich (Switzerland); Schoeffl, Isabelle [Klinikum Bamberg, Department of Pediatrics, Bamberg (Germany); Bongartz, Georg [University Basel, Department of Radiology, Basel (Switzerland)

    2015-01-15

    The objectives of this study were the evaluation of flexor tendon pulley rupture of the fingers in the crimp grip position using magnetic resonance imaging (MRI) and the comparison of the results with MRI in the neutral position in a cadaver study. MRI in the crimp grip position and in the neutral position was performed in 21 cadaver fingers with artificially created flexor tendon pulley tears (combined pulley rupture, n = 14; single pulley rupture, n = 7). Measurement of the distance between the tendon and bone was performed. Images were evaluated by two readers, first independently and in cases of discrepancy in consensus. Sensitivity and specificity for detecting combined pulley ruptures were calculated. Tendon bone distances were significantly higher in the crimp grip position than in the neutral position. Sensitivity and specificity for detecting combined pulley rupture were 92.86 % and 100 % respectively in the crimp grip position and 78.57 % and 85.71 % respectively in the neutral position. Kappa values for interobserver reliability were 0.87 in the crimp grip position and 0.59 in the neutral position. MRI examination in the crimp grip position results in higher tendon bone distances by subjecting the pulleys to a higher strain, which facilitates image evaluation with higher interobserver reliability, higher sensitivity, and higher specificity for combined pulley rupture compared with examination in the neutral position. (orig.)

  7. Functional corticospinal projections from human supplementary motor area revealed by corticomuscular coherence during precise grip force control.

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    Sophie Chen

    Full Text Available The purpose of the present study was to investigate whether corticospinal projections from human supplementary motor area (SMA are functional during precise force control with the precision grip (thumb-index opposition. Since beta band corticomuscular coherence (CMC is well-accepted to reflect efferent corticospinal transmission, we analyzed the beta band CMC obtained with simultaneous recording of electroencephalographic (EEG and electromyographic (EMG signals. Subjects performed a bimanual precise visuomotor force tracking task by applying isometric low grip forces with their right hand precision grip on a custom device with strain gauges. Concurrently, they held the device with their left hand precision grip, producing similar grip forces but without any precision constraints, to relieve the right hand. Some subjects also participated in a unimanual control condition in which they performed the task with only the right hand precision grip while the device was held by a mechanical grip. We analyzed whole scalp topographies of beta band CMC between 64 EEG channels and 4 EMG intrinsic hand muscles, 2 for each hand. To compare the different topographies, we performed non-parametric statistical tests based on spatio-spectral clustering. For the right hand, we obtained significant beta band CMC over the contralateral M1 region as well as over the SMA region during static force contraction periods. For the left hand, however, beta band CMC was only found over the contralateral M1. By comparing unimanual and bimanual conditions for right hand muscles, no significant difference was found on beta band CMC over M1 and SMA. We conclude that the beta band CMC found over SMA for right hand muscles results from the precision constraints and not from the bimanual aspect of the task. The result of the present study strongly suggests that the corticospinal projections from human SMA become functional when high precision force control is required.

  8. Quantification of hand and forearm muscle forces during a maximal power grip task.

    Science.gov (United States)

    Goislard de Monsabert, Benjamin; Rossi, Jérémy; Berton, Eric; Vigouroux, Laurent

    2012-10-01

    The aim of this study was to estimate muscle and joint forces during a power grip task. Considering the actual lack of quantification of such internal variables, this information would be essential for sports sciences, medicine, and ergonomics. This study also contributed to the advancement of scientific knowledge concerning hand control during power grip. A specially designed apparatus combining both an instrumented handle and a pressure map was used to record the forces at the hand/handle interface during maximal exertions. Data were processed such that the forces exerted on 25 hand anatomical areas were determined. Joint angles of the five fingers and the wrist were also computed from synchronized kinematic measurements. These processed data were used as input of a hand/wrist biomechanical model, which includes 23 degrees of freedom and 42 muscles to estimate muscle and joint forces. Greater forces were applied on the distal phalanges of the long fingers compared with the middle and the proximal ones. Concomitantly, high solicitations were observed for FDP muscles. A large cocontraction level of extensor muscles was also estimated by the model and confirmed previously reported activities and injuries of extensor muscles related to the power grip. Quantifying hand internal loadings also resulted in new insights into the thumb and the wrist biomechanics. Output muscle tension ratios were all in smaller ranges than the ones reported in the literature. Including wrist and finger interactions in this hand model provided new quantification of muscle load sharing, cocontraction level, and biomechanics of the hand. Such information could complete future investigations concerning handle ergonomics or pathomechanisms of hand musculoskeletal disorders.

  9. REDUCED HAND GRIP STRENGTH IN OVERWEIGHT AND OBESE CHRONIC HEPATITIS C PATIENTS.

    Science.gov (United States)

    Bruch, Juliana Paula; Álvares-DA-Silva, Mário Reis; Alves, Bruna Cherubini; Dall'alba, Valesca

    2016-01-01

    Hepatitis C is a liver disease that causes significant changes in metabolism, and also has an impact on nutritional status. To evaluate the nutritional status and cardiovascular risk in patients with chronic hepatitis C. This cross-sectional study investigated 58 patients with chronic hepatitis C, non-cirrhotic and were not under active pharmacological treatment. Patients with significant alcohol consumption (greater than 10 g ethanol/day) were excluded. Patients underwent nutritional assessment through anthropometric measurements and functional assessment using hand grip strength by dynamometry. The physical activity was assessed using the International Physical Activity Questionnaire. Patients also underwent clinical and laboratory evaluation. Cardiovascular risk was calculated by the Framingham score. The mean age of patients was 51.6±9.7 years, 55.2% were female, and 79.3% had genotype 1. The most prevalent degree of fibrosis was F1 (37.9%) followed by F2 (27.6%) and F3 (1.7%). The prevalence of overweight/obesity considering the body mass index was 70.7%. However, 57.7% of men and 68.8% of women were considered malnourished according to hand grip strength. These patients also had waist circumference (93.5±10.7 cm) and neck circumference (37.0±3.6 cm) high. Almost 60% of patients were considered sedentary or irregularly active. In relation to cardiovascular risk, 50% of patients had high risk of suffering a cardiovascular event within 10 years. Although most patients with hepatitis C presented overweight, associated with high cardiovascular risk, they also have reduced functional capacity, indicative of protein-caloric commitment. Therefore, body mass index can not be considered the only method of assessment for nutritional diagnosis of patients with liver disease. Adopting methods such as hand grip strength can be important for a better understanding of nutritional status of these patients.

  10. Effects of Anodal Transcranial Direct Current Stimulation on Visually Guided Learning of Grip Force Control

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    Tamas Minarik

    2015-03-01

    Full Text Available Anodal transcranial Direct Current Stimulation (tDCS has been shown to be an effective non-invasive brain stimulation method for improving cognitive and motor functioning in patients with neurological deficits. tDCS over motor cortex (M1, for instance, facilitates motor learning in stroke patients. However, the literature on anodal tDCS effects on motor learning in healthy participants is inconclusive, and the effects of tDCS on visuo-motor integration are not well understood. In the present study we examined whether tDCS over the contralateral motor cortex enhances learning of grip-force output in a visually guided feedback task in young and neurologically healthy volunteers. Twenty minutes of 1 mA anodal tDCS were applied over the primary motor cortex (M1 contralateral to the dominant (right hand, during the first half of a 40 min power-grip task. This task required the control of a visual signal by modulating the strength of the power-grip for six seconds per trial. Each participant completed a two-session sham-controlled crossover protocol. The stimulation conditions were counterbalanced across participants and the sessions were one week apart. Performance measures comprised time-on-target and target-deviation, and were calculated for the periods of stimulation (or sham and during the afterphase respectively. Statistical analyses revealed significant performance improvements over the stimulation and the afterphase, but this learning effect was not modulated by tDCS condition. This suggests that the form of visuomotor learning taking place in the present task was not sensitive to neurostimulation. These null effects, together with similar reports for other types of motor tasks, lead to the proposition that tDCS facilitation of motor learning might be restricted to cases or situations where the motor system is challenged, such as motor deficits, advanced age, or very high task demand.

  11. IMPACT OF COMBINING MIRROR THERAPY AND HABIT ON HAND GRIP STRENGTH IN CHILDREN WITH HEMIPARESIS

    OpenAIRE

    Asmaa A. Abo Nour; Saleh, Muhammad G.; Emam H. Elnagmy

    2016-01-01

    Background: hemiparetic children usually tend to avoid the use of their impaired arm and are remarkably tend to perform inherently bimanual tasks of daily living with the less impaired arm only rather than with both arms. In fact, these children actually may have never learned to use their impaired arm for certain motor tasks or may only use it in the simplest manner, so the purpose of the study was to determine the impact of combining HABIT and mirror therapy on hand grip in hemiparetic chil...

  12. Effect of three different grip angles on physical parameters during laboratory test in handcycling in able-bodied participants

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    Thomas eAbel

    2015-11-01

    Full Text Available Introduction: Handcycling is a relatively new wheelchair sport that has gained increased popularity for people with lower limb disabilities. The aim of this study was to examine the effect of three different grip positions on physical parameters during handcycling in a laboratory setting.Methods: Twenty one able-bodied participants performed three maximum incremental handcycling tests until exhaustion, each with a different grip angle. The angle between the grip and the crank was randomly set at 90° (horizontal, 0° (vertical or 10° (diagonal. The initial load was 20 W and increased by 20 W each five minutes. In addition, participants performed a 20 s maximum effort.Results: The relative peak functional performance (W/kg, peak heart rate (bpm, associated lactate concentrations (mmol/l and peak oxygen uptake per kilogram body weight (ml.min-1.kg-1 for the different grip positions during the stage test were: (a Horizontal: 1.43 ± 0.21 W/kg, 170.14 ± 12.81 bpm, 9.54 ± 1.93 mmol/l, 30.86 ± 4.57 ml/kg; (b Vertical: 1.38 ± 0.20 W/kg, 171.81 ± 13.87 bpm, 9.91 ± 2.29 mmol/l, 29.75 ± 5.13 ml/kg; (c Diagonal: 1.40 ± 0.22 W/kg, 169.19 ± 13.31 bpm, 9.34 ± 2.36 mmol/l, 29.39 ± 4.70 ml/kg. Statistically significant (p <0.05 differences could only be found for lactate concentration between the vertical grip position and the other grips during submaximal handcycling. Conclusion: The orientation of three different grip angles made no difference to the peak load achieved during an incremental handcycling test and a 20 second maximum effort. At submaximal load, higher lactate concentrations were found when the vertical grip position was used, suggesting that this position may be less efficient than the alternative diagonal or horizontal grip positions.

  13. Intra-session and inter-day reliability of forearm surface EMG during varying hand grip forces.

    Science.gov (United States)

    Hashemi Oskouei, Alireza; Paulin, Michael G; Carman, Allan B

    2013-02-01

    Surface electromyography (EMG) is widely used to evaluate forearm muscle function and predict hand grip forces; however, there is a lack of literature on its intra-session and inter-day reliability. The aim of this study was to determine reliability of surface EMG of finger and wrist flexor muscles across varying grip forces. Surface EMG was measured from six forearm flexor muscles of 23 healthy adults. Eleven of these subjects undertook inter-day test-retest. Six repetitions of five randomized isometric grip forces between 0% and 80% of maximum force (MVC) were recorded and normalized to MVC. Intra- and inter-day reliability were calculated through the intraclass correlation coefficient (ICC) and standard error of measurement (SEM). Normalized EMG produced excellent intra-session ICC of 0.90 when repeated measurements were averaged. Intra-session SEM was low at low grip forces, however, corresponding normalized SEM was high (23-45%) due to the small magnitude of EMG signals. This may limit the ability to evaluate finer forearm muscle function and hand grip forces in daily tasks. Combining EMG of functionally related muscles improved intra-session SEM, improving within-subject reliability without taking multiple measurements. Removing and replacing electrodes inter-day produced poor ICC (ICC < 0.50) but did not substantially affect SEM.

  14. A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-α

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    Dickinson Bryony A

    2009-06-01

    Full Text Available Abstract Background Long-term depression (LTD in the hippocampus can be induced by activation of different types of G-protein coupled receptors, in particular metabotropic glutamate receptors (mGluRs and muscarinic acethycholine receptors (mAChRs. Since mGluRs and mAChRs activate the same G-proteins and isoforms of phospholipase C (PLC, it would be expected that these two forms of LTD utilise the same molecular mechanisms. However, we find a distinct mechanism of LTD involving GRIP and liprin-α. Results Whilst both forms of LTD require activation of tyrosine phosphatases and involve internalisation of AMPARs, they use different molecular interactions. Specifically, mAChR-LTD, but not mGluR-LTD, is blocked by peptides that inhibit the binding of GRIP to the AMPA receptor subunit GluA2 and the binding of GRIP to liprin-α. Thus, different receptors that utilise the same G-proteins can regulate AMPAR trafficking and synaptic efficacy via distinct molecular mechanisms. Conclusion Our results suggest that mAChR-LTD selectively involves interactions between GRIP and liprin-α. These data indicate a novel mechanism of synaptic plasticity in which activation of M1 receptors results in AMPAR endocytosis, via a mechanism involving interactions between GluA2, GRIP and liprin-α.

  15. Electric Field Measurements During the Genesis and Rapid Intensification Processes (GRIP) Field Program

    Science.gov (United States)

    Bateman, Monte G.; Blakeslee, Richard J.; Mach, Douglas M.

    2010-01-01

    During the Genesis and Rapid Intensification Processes (GRIP) field program, a system of 6 electric field mills was flown on one of NASA's Global Hawk aircraft. We placed several mills on the aircraft to enable us to measure the vector electric field. We created a distributed, ethernet-connected system so that each sensor has its own embedded Linux system, complete with web server. This makes our current generation system fully "sensor web enabled." The Global Hawk has several unique qualities, but relevant to quality storm electric field measurements are high altitude (20 km) and long duration (20-30 hours) flights. There are several aircraft participating in the GRIP program, and coordinated measurements are happening. Lightning and electric field measurements will be used to study the relationships between lightning and other storm characteristics. It has been long understood that lightning can be used as a marker for strong convective activity. Past research and field programs suggest that lightning flash rate may serve as an indicator and precursor for rapid intensification change in tropical cyclones and hurricanes. We have the opportunity to sample hurricanes for many hours at a time and observe intensification (or de-intensification) periods. The electrical properties of hurricanes during such periods are not well known. American

  16. MusicGlove: motivating and quantifying hand movement rehabilitation by using functional grips to play music.

    Science.gov (United States)

    Friedman, Nizan; Chan, Vicky; Zondervan, Danny; Bachman, Mark; Reinkensmeyer, David J

    2011-01-01

    People with stroke typically must perform much of their hand exercise at home without professional assistance as soon as two weeks after the stroke. Without feedback and encouragement, individuals often lose motivation to practice using the affected hand, and this disuse contributes to further declines in hand function. We developed the MusicGlove as a way to facilitate and motivate at home practice of hand movement. This low-cost device uses music as an interactive and motivating medium to guide hand exercise and to quantitatively assess hand movement recovery. It requires the user to practice functional movements, including pincer grip, key-pinch grip, and finger-thumb opposition, by using those movements to play different musical notes, played along to songs displayed by an interactive computer game. We report here the design of the glove and the results of a single-session experiment with 10 participants with chronic stroke. We found that the glove is well suited for use by people with an impairment level quantified by a Box and Blocks score of at least around 7; that the glove can be used to obtain a measure of hand dexterity (% of notes hit) that correlates strongly with the Box and Blocks score; and that the incorporation of music into training significantly improved both objective measures of hand motor performance and self-ratings of motivation for training in the single session.

  17. Effect of skin hydration on the dynamics of fingertip gripping contact

    Science.gov (United States)

    André, T.; Lévesque, V.; Hayward, V.; Lefèvre, P.; Thonnard, J.-L.

    2011-01-01

    The dynamics of fingertip contact manifest themselves in the complex skin movements observed during the transition from a stuck state to a fully developed slip. While investigating this transition, we found that it depended on skin hydration. To quantify this dependency, we asked subjects to slide their index fingertip on a glass surface while keeping the normal component of the interaction force constant with the help of visual feedback. Skin deformation inside the contact region was imaged with an optical apparatus that allowed us to quantify the relative sizes of the slipping and sticking regions. The ratio of the stuck skin area to the total contact area decreased linearly from 1 to 0 when the tangential force component increased from 0 to a maximum. The slope of this relationship was inversely correlated to the normal force component. The skin hydration level dramatically affected the dynamics of the contact encapsulated in the course of evolution from sticking to slipping. The specific effect was to reduce the tendency of a contact to slip, regardless of the variations of the coefficient of friction. Since grips were more unstable under dry skin conditions, our results suggest that the nervous system responds to dry skin by exaggerated grip forces that cannot be simply explained by a change in the coefficient of friction. PMID:21490002

  18. Muscular forearm activation in hand-grip tasks with superimposition of mechanical vibrations.

    Science.gov (United States)

    Fattorini, L; Tirabasso, A; Lunghi, A; Di Giovanni, R; Sacco, F; Marchetti, E

    2016-02-01

    The purpose of this paper is to evaluate the muscular activation of the forearm, with or without vibration stimuli at different frequencies while performing a grip tasks of 45s at various level of exerted force. In 16 individuals, 9 females and 7 males, the surface electromyogram (EMG) of extensor carpi radialis longus and the flexor carpi ulnari muscles were assessed. At a short latency from onset EMG, RMS and the level of MU synchronization were assessed to evaluate the muscular adaptations. Whilst a trend of decay of EMG Median frequency (MDFd) was employed as an index of muscular fatigue. Muscular tasks consists of the grip of an instrumented handle at a force level of 20%, 30%, 40%, 60% of the maximum voluntary force. Vibration was supplied by a shaker to the hand in mono-frequential waves at 20, 30, 33 and 40Hz. In relation to EMG, RMS and MU synchronization, the muscular activation does not seem to change with the superimposition of the mechanical vibrations, on the contrary a lower MDFd was observed at 33Hz than in absence of vibration. This suggests an early muscular fatigue induced by vibration due to the fact that 33Hz is a resonance frequency for the hand-arm system.

  19. The administration and interpretation of the rapid exchange grip test: a national survey.

    Science.gov (United States)

    Shechtman, Orit; Goodall, Sara K

    2008-01-01

    The purpose of the present study was to determine if the administration and interpretation of the rapid exchange grip (REG) test vary among hand therapists nationally. The REG is used to determine sincerity of effort of grip strength. There are inconsistencies in the literature regarding the administration and interpretation of the REG, as various studies use different testing protocols and diverse interpretation criteria for what constitutes a sincere effort. As a result, we expected to find a lack of standardization in the administration and interpretation of the REG in clinical practice. We conducted a random nationwide survey of 200 hand therapists. The questionnaire items regarding the administration of the REG included patient position, test instructions, handle settings, handling of the dynamometer, hand switch rate, number of repetitions, and techniques used to record the score. The items for the interpretation of the REG involved questions regarding comparative tests. We found that the REG test lacks standardized administration protocols and interpretation criteria among therapists nationwide. The lack of standardization is likely to affect the reliability and validity of the REG and to hinder the therapist's ability to accurately report its outcomes. The implications of lack of standardization in assessment techniques to the profession are discussed.

  20. Is the coefficient of variation a valid measure for detecting sincerity of effort of grip strength?

    Science.gov (United States)

    Shechtman, Orit

    1999-01-01

    The wide use of the coefficient of variation in detecting sincerity of effort is puzzling since existing research findings regarding its effectiveness are contradictory. The lack of empirical support in the literature raises the question of whether or not the coefficient of variation is a valid measure for detecting sincerity of effort. Many clinicians, especially those who use a computer software to calculate the coefficient of variation, may not understand how the coefficient of variation is derived and what it is based on. The coefficient of variation is a measure of relative variability and would be used correctly only if the average and the standard deviation of grip strength trials increased proportionally. This case study, however, demonstrated that the average and standard deviation of grip strength are independent. Thus, the coefficient of variation is not a valid measure of sincerity of effort. In addition, this study indicated that the coefficient of variation may be inflated in individuals after carpal tunnel release surgery. The author, therefore, cautions clinicians against the use of the coefficient of variation as a measure of sincerity of effort especially in injured individuals with compromised hand strength.

  1. Grip selection for sequential movements in children and adults with and without Developmental Coordination Disorder.

    Science.gov (United States)

    Wilmut, Kate; Byrne, Maia

    2014-08-01

    When generating a movement adults favor grasps which start the body in an uncomfortable position if they end in a comfortable position (the end-state-comfort effect). In contrast, children with Developmental Coordination Disorder (DCD) select grasps which require little initial hand rotation even though they result in an uncomfortable end position. The current study considered grip selection of individuals with DCD when asked to make simple one step movements and when making more complex multi-staged movements. Adults with DCD (N=17, mean age 24:09, SD age=52months) and children with DCD (N=20, mean age 9:00, SD age=20months) and age and gender matched controls rotated a disc so an arrow pointed toward a specific target(s). Task complexity was increased by increasing the number of targets from 1 to 3. Planning for end-state-comfort was seen in all groups albeit to a lesser extent in children versus adults. The children with DCD showed fewer grips for end-state-comfort compared to their peers and this was explained by a propensity to select minimal initial rotation grasps. This result was mirrored in adults with DCD but only for the longest movement sequence. These results suggest some changes in ability from childhood to adulthood in individuals with DCD.

  2. The brain adjusts grip forces differently according to gravity and inertia: a parabolic flight experiment.

    Science.gov (United States)

    White, Olivier

    2015-01-01

    In everyday life, one of the most frequent activities involves accelerating and decelerating an object held in precision grip. In many contexts, humans scale and synchronize their grip force (GF), normal to the finger/object contact, in anticipation of the expected tangential load force (LF), resulting from the combination of the gravitational and the inertial forces. In many contexts, GF and LF are linearly coupled. A few studies have examined how we adjust the parameters-gain and offset-of this linear relationship. However, the question remains open as to how the brain adjusts GF regardless of whether LF is generated by different combinations of weight and inertia. Here, we designed conditions to generate equivalent magnitudes of LF by independently varying mass and movement frequency. In a control experiment, we directly manipulated gravity in parabolic flights, while other factors remained constant. We show with a simple computational approach that, to adjust GF, the brain is sensitive to how LFs are produced at the fingertips. This provides clear evidence that the analysis of the origin of LF is performed centrally, and not only at the periphery.

  3. Hurricane Imaging Radiometer Wind Speed and Rain Rate Retrievals during the 2010 GRIP Flight Experiment

    Science.gov (United States)

    Sahawneh, Saleem; Farrar, Spencer; Johnson, James; Jones, W. Linwood; Roberts, Jason; Biswas, Sayak; Cecil, Daniel

    2014-01-01

    Microwave remote sensing observations of hurricanes, from NOAA and USAF hurricane surveillance aircraft, provide vital data for hurricane research and operations, for forecasting the intensity and track of tropical storms. The current operational standard for hurricane wind speed and rain rate measurements is the Stepped Frequency Microwave Radiometer (SFMR), which is a nadir viewing passive microwave airborne remote sensor. The Hurricane Imaging Radiometer, HIRAD, will extend the nadir viewing SFMR capability to provide wide swath images of wind speed and rain rate, while flying on a high altitude aircraft. HIRAD was first flown in the Genesis and Rapid Intensification Processes, GRIP, NASA hurricane field experiment in 2010. This paper reports on geophysical retrieval results and provides hurricane images from GRIP flights. An overview of the HIRAD instrument and the radiative transfer theory based, wind speed/rain rate retrieval algorithm is included. Results are presented for hurricane wind speed and rain rate for Earl and Karl, with comparison to collocated SFMR retrievals and WP3D Fuselage Radar images for validation purposes.

  4. The effect of vibration exposure during haul truck operation on grip strength, touch sensation, and balance.

    Science.gov (United States)

    Pollard, Jonisha; Porter, William; Mayton, Alan; Xu, Xueyan; Weston, Eric

    2017-01-01

    Falls from mobile equipment are reported at surface mine quarry operations each year in considerable numbers. Research shows that a preponderance of falls occur while getting on/off mobile equipment. Contributing factors to the risk of falls include the usage of ladders, exiting onto a slippery surface, and foot or hand slippage. Balance issues may also contribute to fall risks for mobile equipment operators who are exposed to whole-body vibration (WBV). For this reason, the National Institute for Occupational Safety and Health, Office of Mine Safety and Health Research conducted a study at four participating mine sites with seven haul truck operators. The purpose was to ascertain whether WBV and hand-arm vibration (HAV) exposures for quarry haul truck operators were linked to short-term decreases in performance in relation to postural stability, touch sensation threshold, and grip strength that are of crucial importance when getting on/off the trucks. WBV measures of frequency-weighted RMS accelerations (wRMS) and vibration dose value (VDV), when compared to the ISO/ANSI standards, were mostly below levels identified for the Health Guidance Caution Zone (HGCZ), although there were instances where the levels were within and above the specified Exposure Action Value. Comparably, all mean HAV levels, when compared to the ISO/ANSI standards, were below the HGCZ. For the existing conditions and equipment, no significant correlation could be identified between the WBV, HAV, postural stability, touch sensation threshold, and grip strength measures taken during this study.

  5. Positive force feedback in development of substrate grip in the stick insect tarsus.

    Science.gov (United States)

    Zill, Sasha N; Chaudhry, Sumaiya; Exter, Annelie; Büschges, Ansgar; Schmitz, Josef

    2014-09-01

    The mechanics of substrate adhesion has recently been intensively studied in insects but less is known about the sensorimotor control of substrate engagement. We characterized the responses and motor effects of tarsal campaniform sensilla in stick insects to understand how sensory signals of force could contribute to substrate grip. The tarsi consist of a chain of segments linked by highly flexible articulations. Morphological studies showed that one to four campaniform sensilla are located on the distal end of each segment. Activities of the receptors were recorded neurographically and sensilla were identified by stimulation and ablation of their cuticular caps. Responses were characterized to bending forces and axial loads, muscle contractions and to forces applied to the retractor apodeme (tendon). The tarsal sensilla effectively encoded both the rate and amplitude of loads and muscle forces, but only when movement was resisted. Mechanical stimulation of the receptors produced activation of motor neurons in the retractor unguis and tibial flexor muscles. These findings indicate that campaniform sensilla can provide information about the effectiveness of the leg muscles in generating substrate adherence. They can also produce positive force feedback that could contribute to the development of substrate grip and stabilization of the tarsal chain.

  6. The coefficient of variation as a measure of sincerity of effort of grip strength, Part I: the statistical principle.

    Science.gov (United States)

    Shechtman, O

    2001-01-01

    The coefficient of variation (CV) is a widely used measure of sincerity of effort of grip strength despite contradictory research findings and lack of empirical support in the literature. The purpose of this study was to investigate whether the CV is an appropriate measure of sincerity of effort. One hundred forty-six uninjured volunteers underwent a series of grip strength tests. The mean, standard deviation (SD), and CV of repeated strength trials were calculated, and paired comparisons were conducted between maximal and submaximal efforts. While the mean of maximal trials was significantly greater, there were no differences in SD between maximal and submaximal trials. Therefore, the increased CV associated with submaximal effort was an artifact of reduced torque rather than an indicator of a true increase in variability. Consequently, the CV is not an appropriate measure of sincerity of effort of grip strength.

  7. GRIP: A web-based system for constructing Gold Standard datasets for protein-protein interaction prediction.

    Science.gov (United States)

    Browne, Fiona; Wang, Haiying; Zheng, Huiru; Azuaje, Francisco

    2009-01-26

    Information about protein interaction networks is fundamental to understanding protein function and cellular processes. Interaction patterns among proteins can suggest new drug targets and aid in the design of new therapeutic interventions. Efforts have been made to map interactions on a proteomic-wide scale using both experimental and computational techniques. Reference datasets that contain known interacting proteins (positive cases) and non-interacting proteins (negative cases) are essential to support computational prediction and validation of protein-protein interactions. Information on known interacting and non interacting proteins are usually stored within databases. Extraction of these data can be both complex and time consuming. Although, the automatic construction of reference datasets for classification is a useful resource for researchers no public resource currently exists to perform this task. GRIP (Gold Reference dataset constructor from Information on Protein complexes) is a web-based system that provides researchers with the functionality to create reference datasets for protein-protein interaction prediction in Saccharomyces cerevisiae. Both positive and negative cases for a reference dataset can be extracted, organised and downloaded by the user. GRIP also provides an upload facility whereby users can submit proteins to determine protein complex membership. A search facility is provided where a user can search for protein complex information in Saccharomyces cerevisiae. GRIP is developed to retrieve information on protein complex, cellular localisation, and physical and genetic interactions in Saccharomyces cerevisiae. Manual construction of reference datasets can be a time consuming process requiring programming knowledge. GRIP simplifies and speeds up this process by allowing users to automatically construct reference datasets. GRIP is free to access at http://rosalind.infj.ulst.ac.uk/GRIP/.

  8. GRIP: A web-based system for constructing Gold Standard datasets for protein-protein interaction prediction

    Directory of Open Access Journals (Sweden)

    Zheng Huiru

    2009-01-01

    Full Text Available Abstract Background Information about protein interaction networks is fundamental to understanding protein function and cellular processes. Interaction patterns among proteins can suggest new drug targets and aid in the design of new therapeutic interventions. Efforts have been made to map interactions on a proteomic-wide scale using both experimental and computational techniques. Reference datasets that contain known interacting proteins (positive cases and non-interacting proteins (negative cases are essential to support computational prediction and validation of protein-protein interactions. Information on known interacting and non interacting proteins are usually stored within databases. Extraction of these data can be both complex and time consuming. Although, the automatic construction of reference datasets for classification is a useful resource for researchers no public resource currently exists to perform this task. Results GRIP (Gold Reference dataset constructor from Information on Protein complexes is a web-based system that provides researchers with the functionality to create reference datasets for protein-protein interaction prediction in Saccharomyces cerevisiae. Both positive and negative cases for a reference dataset can be extracted, organised and downloaded by the user. GRIP also provides an upload facility whereby users can submit proteins to determine protein complex membership. A search facility is provided where a user can search for protein complex information in Saccharomyces cerevisiae. Conclusion GRIP is developed to retrieve information on protein complex, cellular localisation, and physical and genetic interactions in Saccharomyces cerevisiae. Manual construction of reference datasets can be a time consuming process requiring programming knowledge. GRIP simplifies and speeds up this process by allowing users to automatically construct reference datasets. GRIP is free to access at http://rosalind.infj.ulst.ac.uk/GRIP/.

  9. Modeling the Maturation of Grip Selection Planning and Action Representation: Insights from Typical and Atypical Motor Development.

    Directory of Open Access Journals (Sweden)

    Ian eFuelscher

    2016-02-01

    Full Text Available We investigated the purported association between developmental changes in grip selection planning and improvements in an individual’s capacity to represent action at an internal level (i.e., motor imagery. Participants were groups of healthy children aged 6-7 years and 8-12 years respectively, while a group of adolescents (13-17 years and adults (18-34 years allowed for consideration of childhood development in the broader context of motor maturation. A group of children aged 8-12 years with probable DCD (pDCD was included as a reference group for atypical motor development. Participants’ proficiency to generate and/or engage internal action representations was inferred from performance on the hand rotation task, a well-validated measure of motor imagery. A grip selection task designed to elicit the end-state comfort (ESC effect provided a window into the integrity of grip selection planning. Consistent with earlier accounts, the efficiency of grip selection planning followed a non-linear developmental progression in neurotypical individuals. As expected, analysis confirmed that these developmental improvements were predicted by an increased capacity to generate and/or engage internal action representations. The profile of this association remained stable throughout the (typical developmental spectrum. These findings are consistent with computational accounts of action planning that argue that internal action representations are associated with the expression and development of grip selection planning across typical development. However, no such association was found for our sample of children with pDCD, suggesting that individuals with atypical motor skill may adopt an alternative, sub-optimal strategy to plan their grip selection compared to their same-age control peers.

  10. [Evaluation of grip strength in normal and obese Wistar rats submitted to swimming with overload after median nerve compression].

    Science.gov (United States)

    Coradinia, Josinéia Gresele; Kakihata, Camila Mayumi Martin; Kunz, Regina Inês; Errero, Tatiane Kamada; Bonfleur, Maria Lúcia; Bertolini, Gladson Ricardo Flor

    2015-01-01

    To verify the functionality through muscle grip strength in animals with obesity induced by monosodium glutamate (MSG) and in control animals, which suffered compression of the right median nerve, and treated with swimming with overload. During the first five days of life, neonatal Wistar rats received subcutaneous injections of MSG. The control group received a hypertonic saline solution. Forty-eight rats were divided into six groups: G1 (control); G2 (control + injury); G3 (control + injury + swimming); G4 (obese); G5 (obese + injury); G6 (obese + injury + swimming). The animals in groups G2, G3, G5 and G6 were submitted to compression of the median nerve and G3 and G6 groups were treated, after injury, with swimming exercise with load for three weeks. The swimming exercise had a progressive duration, according to the week, of 20, 30 and 40minutes. Muscle strength was assessed using a grip strength meter preoperatively and on the 3rd, 7th, 14th and 21st days after surgery. The results were expressed and analyzed using descriptive and inferential statistics. When the grip strength was compared among assessments regardless of group, in the second assessment the animals exhibited lower grip strength. G1 and G4 groups had greater grip strength, compared to G2, G3, G4 and G6. The swimming exercise with overload has not been effective in promoting improvement in muscle grip strength after compression injury of the right median nerve in control and in obese-MSG rats. Copyright © 2013 Elsevier Editora Ltda. All rights reserved.

  11. Modeling the Maturation of Grip Selection Planning and Action Representation: Insights from Typical and Atypical Motor Development

    Science.gov (United States)

    Fuelscher, Ian; Williams, Jacqueline; Wilmut, Kate; Enticott, Peter G.; Hyde, Christian

    2016-01-01

    We investigated the purported association between developmental changes in grip selection planning and improvements in an individual’s capacity to represent action at an internal level [i.e., motor imagery (MI)]. Participants were groups of healthy children aged 6–7 years and 8–12 years respectively, while a group of adolescents (13–17 years) and adults (18–34 years) allowed for consideration of childhood development in the broader context of motor maturation. A group of children aged 8–12 years with probable DCD (pDCD) was included as a reference group for atypical motor development. Participants’ proficiency to generate and/or engage internal action representations was inferred from performance on the hand rotation task, a well-validated measure of MI. A grip selection task designed to elicit the end-state comfort (ESC) effect provided a window into the integrity of grip selection planning. Consistent with earlier accounts, the efficiency of grip selection planning followed a non-linear developmental progression in neurotypical individuals. As expected, analysis confirmed that these developmental improvements were predicted by an increased capacity to generate and/or engage internal action representations. The profile of this association remained stable throughout the (typical) developmental spectrum. These findings are consistent with computational accounts of action planning that argue that internal action representations are associated with the expression and development of grip selection planning across typical development. However, no such association was found for our sample of children with pDCD, suggesting that individuals with atypical motor skill may adopt an alternative, sub-optimal strategy to plan their grip selection compared to their same-age control peers. PMID:26903915

  12. Reliability of the grip strength coefficient of variation for detecting sincerity in normal and blocked median nerve in healthy adults.

    Science.gov (United States)

    Wachter, N J; Mentzel, M; Hütz, R; Gülke, J

    2017-04-01

    In the assessment of hand and upper limb function, detecting sincerity of effort (SOE) for grip strength is of major importance to identifying feigned loss of strength. Measuring maximal grip strength with a dynamometer is very common, often combined with calculating the coefficient of variation (CV), a measure of the variation over the three grip strength trials. Little data is available about the relevance of these measurements in patients with median nerve impairment due to the heterogeneity of patient groups. This study examined the reliability of grip strength tests as well as the CV to detect SOE in healthy subjects. The power distribution of the individual fingers and the thenar was taken into account. To assess reliability, the measurements were performed in subjects with a median nerve block to simulate a nerve injury. The ability of 21 healthy volunteers to exert maximal grip force and to deliberately exert half-maximal force to simulate reduced SOE in a power grip was examined using the Jamar(®) dynamometer. The experiment was performed in a combined setting with and without median nerve block of the same subject. The force at the fingertips of digits 2-5 and at the thenar eminence was measured with a sensor glove with integrated pressure receptors. For each measurement, three trials were recorded subsequently and the mean and CV were calculated. When exerting submaximal force, the subjects reached 50-62% of maximal force, regardless of the median nerve block. The sensor glove revealed a significant reduction of force when exerting submaximal force (P1 sensor) with (P<0.032) and without median nerve block (P<0.017). An increase in CV at submaximal force was found, although it was not significant. SOE can be detected with the CV at the little finger at using a 10% cut-off (sensitivity 0.84 and 0.92 without and with median nerve block, respectively). These findings suggest low reliability of the power grip measurement with the Jamar(®) dynamometer, as

  13. Effect of isometric hand grip on heart rate in normotensive and hypertensive individuals during head up tilt (300 and 600)

    OpenAIRE

    Badwe, A. N.; Latti, Ramchandra Girimalappa

    2017-01-01

    Objective: To study the effect of isometric hand grip exercise at 20% on normotensive, treated hypertensive, and non treated hypertensive in supine position, and at 300 and 600 head up tilt.Material and Methods: After recording heart rate in supine position, isometric hand grip exercise at 20% was conducted for 2 minutes with dominant hand and heart rate was recorded for 1 minute in all subjects after end of the exercise. The same maneuver was repeated before head up tilt in supine position a...

  14. Recent Developments: The Gamma Ray Imager/Polarimeter for Solar Flares (GRIPS) Imaging and Detector systems

    Science.gov (United States)

    Duncan, Nicole; Shih, A. Y.; Hurford, G. J.; Saint-Hilaire, P.; Bain, H.; Zoglauer, A.; Lin, R. P.; Boggs, S. E.

    2013-07-01

    In two of the best-observed flares of the last cycle, the Reuven Ramaty High-Energy Solar Spectroscopic Imager (RHESSI) satellite found the centroids of ion and relativistic electron emission to have a significant displacement. This result is surprising; co-spatially accelerated ions and electrons are thought to be transported along the same field lines, implying they would enter the chromosphere together and have similar emission locations. The Gamma-Ray Imager/Polarimeter for Solar Flares (GRIPS) balloon instrument will investigate particle transport in solar flares by providing enhanced imaging, spectroscopy and polarimetry of gamma/HXR flare emission (20keV - 10MeV). GRIPS’ key technological improvements over the solar state of the art in HXR/gamma ray energies (RHESSI) include three-dimensional position-sensitive germanium detectors (3D-GeDs) and a single-grid modulating collimator, the multi-pitch rotating modulator (MPRM). The 3D-GeDs allow GRIPS to Compton track energy deposition within the crystal. This capability (1) enables the MPRM design by acting as a second modulation grid, (2) provides significant background rejection and (3) makes solar polarization measurements possible. The MPRM imager provides quasi-continuous resolution from 12.5 - 162 arcsecs with 2x the throughput of a dual grid collimator system like RHESSI. This spatial resolution can resolve the separate footpoints of many flare sizes. In comparison, RHESSI images with a minimum of 35 arcsecs for gamma-rays, making these footpoints resolvable in only the largest flares. Here, we present the intial calibration of GRIPS’ 3D-GED detectors using laboratory radioactive sources. We evaluate charge sharing between adjacent strips, the detection of coincidences and preliminary depth measurements. The detectors have been shown to have a linear response and resolve line emission. The MPRM modulation grid is constructed and we present initial results from calibration. GRIPS is scheduled for a

  15. Strengthening the reporting of genetic risk prediction studies: the GRIPS statement.

    Science.gov (United States)

    Janssens, A Cecile J W; Ioannidis, John P A; van Duijn, Cornelia M; Little, Julian; Khoury, Muin J

    2011-09-01

    • The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice. • The number of studies assessing the predictive ability is steadily increasing, but the quality and completeness of reporting vary. • A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines. • These recommendations aim to enhance the transparency of study reporting and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis. • A detailed Explanation and Elaboration document is published as an accompanying article [1].

  16. Electromagnet Gripping in Iron Foundry Automation Part I: Principles and Framework

    Directory of Open Access Journals (Sweden)

    Rhythm Suren Wadhwa

    2011-11-01

    Full Text Available Robot grippers are employed to position and retain parts in automated assembly operations. This paper presents an overview of electromagnet part handling framework in an iron foundry and an equivalent electromagnet circuit model. The manner in which this whole concept of automated gripping system operates will be discussed in this paper. The material handling system uses machine vision system coupled with conveyor motion and Ethernet communication strategy to assist the material handling system for transporting the foundry parts. The paper provides an overview of the electromagnet principles at play. The electromagnet interaction with the part is the key issue in the robust handling of this automated foundry system. This paper helps in the realization of the concept of automation in an iron foundry, in which the number of published studies is very limited.

  17. Electrical conductivity measurements from the GISP2 and GRIP Greenland ice cores

    DEFF Research Database (Denmark)

    Dahl-Jensen, Dorthe; Clausen, Henrik Brink; Taylor, K. C.

    1993-01-01

    . Here we present electrical conductivity records for the Greenland Ice Sheet Project 2 (GISP2) and Greenland Ice-core Project (GRIP) ice cores, drilled 28 km apart to enable direct comparison of the results. The upper parts of both records are consistent with previous evidence from other Greenland cores......THE direct-current electrical conductivity of glacial ice depends on its acidity1-3, and can also indicate changes in climate, as ice formed in cold, dusty periods has a high concentration of alkaline dust1,4,5, which significantly reduces the conductivity6,7 compared to warmer, less dusty periods......4,8& #150;12 for a stable Greenland climate during the Holocene, and a series of warm events punctuating the last glacial period. However, there is a significant discrepancy between the two records in the bottom 10% of the cores, calling into question recent reports of climate variability...

  18. Using the coefficient of variation to detect sincerity of effort of grip strength: a literature review.

    Science.gov (United States)

    Shechtman, O

    2000-01-01

    Many clinicians use the coefficient of variation (CV) to assess sincerity of effort, without understanding the premise on which it is based or its physiological and mathematical bases. Clinicians who use computerized evaluation systems that calculate the CV may not even be aware of the formula used to derive it. The wide use of the CV in detecting sincerity of effort of grip strength is puzzling, since it lacks empirical support in the literature. This paper examines the physiological rationale for using measures of variability to detect sincerity of effort, the mathematical basis on which the CV is founded, and the reliability and validity of the CV. The conclusions based on this literature review are that the CV is not an appropriate method for determining whether an effort is sincere and that CV values may be inflated in injured patients with compromised hand strength.

  19. Relevance of the EMG/grip relationship in isometric anisotonic conditions.

    Science.gov (United States)

    Claudon, Laurent

    2003-01-01

    The aim of the present study was to develop a relationship to evaluate grip force using the electromyogram (EMG) in isometric anisotonic conditions. The EMGs of the flexor digitorum superficialis (FDS) and the extensor digitorum (ED) were recorded in 3 flexion-extension positions of the wrist (30 degrees flexion, 30 degrees extension, and 60 degrees extension) associated with 3 positions of the forearm (70 degrees pronation, prono-supination, and 70 degrees supination). For each position, the participants had to follow linear ramp targets (2 rates of increase and decrease) displayed on an oscilloscope. The results show the best fit is a quadratic type force-EMG relationship. Some aspects such as the rate of force variation and the forearm and wrist positions are then discussed along with the limitations of the relationship.

  20. Computer vision-based classification of hand grip variations in neurorehabilitation.

    Science.gov (United States)

    Zariffa, José; Steeves, John D

    2011-01-01

    The complexity of hand function is such that most existing upper limb rehabilitation robotic devices use only simplified hand interfaces. This is in contrast to the importance of the hand in regaining function after neurological injury. Computer vision technology has been used to identify hand posture in the field of Human Computer Interaction, but this approach has not been translated to the rehabilitation context. We describe a computer vision-based classifier that can be used to discriminate rehabilitation-relevant hand postures, and could be integrated into a virtual reality-based upper limb rehabilitation system. The proposed system was tested on a set of video recordings from able-bodied individuals performing cylindrical grasps, lateral key grips, and tip-to-tip pinches. The overall classification success rate was 91.2%, and was above 98% for 6 out of the 10 subjects. © 2011 IEEE

  1. Hurricanes Karl and Tropical Storm Matthew Structure Observed by HIWRAP During GRIP

    Science.gov (United States)

    Heymsfield, G. M.; Guimond, S. R.; Tian, L.

    2012-12-01

    The dual-wavelength (Ku and Ka band) High-Altitude Imaging Wind and Rain Airborne Profiler (HIWRAP) flew for the first time on the Global Hawk during the 2010 Genesis and Rapid Intensification Processes (GRIP). HIWRAP is conical scanning and Doppler, and winds and reflectivity can be mapped within the swath below the Global Hawk. Two interesting cases from the HIWRAP flights were the rapid intensification of Hurricane Karl and the intensification of Tropical Storm Matthew. This presentation will highlight the precipitation and wind structure of these storms during their intensification as derived from the HIWRAP observations. If time permits and if available, highlights from HIWRAP observations from the Hurricane Severe Storm Sentinel (HS3) field campaign in September 2012 will be presented.

  2. Physical function, grip strength and frailty in people living with HIV in sub-Saharan Africa: systematic review.

    Science.gov (United States)

    Bernard, Charlotte; Dabis, François; de Rekeneire, Nathalie

    2017-05-01

    To present the current knowledge on physical function, grip strength and frailty in HIV-infected patients living in sub-Saharan Africa, where the phenomenon is largely underestimated. A systematic search was conducted on MEDLINE, Scopus and African Index Medicus. We reviewed articles on sub-Saharan African people living with HIV (PLHIV) >18 years old, published until November 2016. Of 537 articles, 12 were conducted in six African countries and included in this review. Five articles reported information on functional limitation and one on disability. Two of these five articles reported functional limitation (low gait speed) in PLHIV. Disability was observed in 27% and 3% of PLHIV living in rural and urban places, respectively. Two of three studies reporting grip strength reported lower grip strength (nearly 4 kg) in PLHIV in comparison with uninfected patients. One study reported that PLHIV were more likely to be frail than HIV-uninfected individuals (19.4% vs. 13.3%), whereas another reported no statistical difference. Decline in physical function, grip strength and frailty are now part of the burden of PLHIV living in SSA countries, but current data are insufficient to characterise the real public health dimension of these impairments. Further studies are needed to depict this major public health challenge. As this is likely to contribute to a significant burden on the African healthcare systems and human resources in the near future, a holistic care approach should be developed to inform guidelines. © 2017 John Wiley & Sons Ltd.

  3. The application of an external wrist extension force reduces electromyographic activity of wrist extensor muscles during gripping.

    NARCIS (Netherlands)

    Elk, N. van; Faes, M.C.; Degens, H.; Kooloos, J.G.M.; Lint, J.A. de; Hopman, M.T.E.

    2004-01-01

    STUDY DESIGN: Experimental repeated-measures study. OBJECTIVE: To investigate the effect of different extension forces applied to the palm of the hand on electromyographic (EMG) activity of the wrist extensor muscles during hand gripping. BACKGROUND: Lateral epicondylitis is usually caused by repeti

  4. Using goal- and grip-related information for understanding the correctness of other's actions: an ERP study.

    Science.gov (United States)

    van Elk, Michiel; Bousardt, Roel; Bekkering, Harold; van Schie, Hein T

    2012-01-01

    Detecting errors in other's actions is of pivotal importance for joint action, competitive behavior and observational learning. Although many studies have focused on the neural mechanisms involved in detecting low-level errors, relatively little is known about error-detection in everyday situations. The present study aimed to identify the functional and neural mechanisms whereby we understand the correctness of other's actions involving well-known objects (e.g. pouring coffee in a cup). Participants observed action sequences in which the correctness of the object grasped and the grip applied to a pair of objects were independently manipulated. Observation of object violations (e.g. grasping the empty cup instead of the coffee pot) resulted in a stronger P3-effect than observation of grip errors (e.g. grasping the coffee pot at the upper part instead of the handle), likely reflecting a reorienting response, directing attention to the relevant location. Following the P3-effect, a parietal slow wave positivity was observed that persisted for grip-errors, likely reflecting the detection of an incorrect hand-object interaction. These findings provide new insight in the functional significance of the neurophysiological markers associated with the observation of incorrect actions and suggest that the P3-effect and the subsequent parietal slow wave positivity may reflect the detection of errors at different levels in the action hierarchy. Thereby this study elucidates the cognitive processes that support the detection of action violations in the selection of objects and grips.

  5. Stretch calculated from grip distance accurately approximates mid-specimen stretch in large elastic arteries in uniaxial tensile tests.

    Science.gov (United States)

    Tian, Lian; Henningsen, Joseph; Salick, Max R; Crone, Wendy C; Gunderson, McLean; Dailey, Seth H; Chesler, Naomi C

    2015-07-01

    The mechanical properties of vascular tissues affect hemodynamics and can alter disease progression. The uniaxial tensile test is a simple and effective method for determining the stress-strain relationship in arterial tissue ex vivo. To enable calculation of strain, stretch can be measured directly with image tracking of markers on the tissue or indirectly from the distance between the grips used to hold the specimen. While the imaging technique is generally considered more accurate, it also requires more analysis, and the grip distance method is more widely used. The purpose of this study is to compare the stretch of the testing specimen calculated from the grip distance method to that obtained from the imaging method for canine descending aortas and large proximal pulmonary arteries. Our results showed a significant difference in stretch between the two methods; however, this difference was consistently less than 2%. Therefore, the grip distance method is an accurate approximation of the stretch in large elastic arteries in the uniaxial tensile test. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. The Grip on the Handball – A Qualitative Analysis of the Influence of Materiality on Creativity in Sport

    DEFF Research Database (Denmark)

    Tanggaard, Lene; Laursen, Dan Nørgaard; Szulevicz, Thomas

    2015-01-01

    how balls made of synthetic polyurethane contribute to a better grip on the ball, which has led to new possibilities for attacking players in handball. The conclusion is that the leather handball is a mediating object, which co-creates the possibilities that the players have in expressing themselves...

  7. Constraints on grip selection in hemiparetic cerebral palsy: Effects of lesional side, end-point accuracy and context.

    NARCIS (Netherlands)

    Steenbergen, B.; Meulenbroek, R.G.J.; Rosenbaum, D.A.

    2004-01-01

    This study was concerned with the selection criteria used for grip planning in adolescents with left or right hemiparetic cerebral palsy. In the first experiment participants picked up a pencil and placed the tip in a pre-defined target region. We varied the size of the target to test the hypothesis

  8. [Reliability and validity of the analysis of hand grip and pinch force in isometric and isokinetic conditions].

    Science.gov (United States)

    Benaglia, P G; Franchignoni, F; Ferriero, G; Zebellin, G; Sartorio, F

    1999-01-01

    Strength measurement of the hand grip is at the core of most protocols of functional assessment of the upper limb and in rehabilitation plays a major role in the analysis of treatment efficacy and patients' occupational ability. The aims of this study were to: a) verify the repeatability of strength measurements made during performance of the hand grip and three types of pinch, carried out under isometric and isokinetic conditions; b) compare maximal isometric strength with the corresponding isokinetic value for each of the manoeuvres studied; c) investigate the correlations between the strength expressed in the different manoeuvres, under both isometric and isokinetic conditions. We studied 14 voluntary subjects over three sessions conducted at 48-hr intervals, employing a computerized isokinetic dynamometer Lido WorkSet equipped with device N(o) 21 for the study of pinch (lateral pinch, pulp pinch, chuck pinch) and device N(o) 52 for the grip study. Isometric contractions resulted stronger than isokinetic ones, and the hand grip was found to be the manoeuvre able to produce most strength. The repeatability of each strength measurement test over the three days was high (Intraclass Correlation Coefficients: 0.89-0.93). Correlations between the isometric and isokinetic performance for each of the manoeuvres examined were always high (Pearson's r coefficients: 0.89-0.95) as were those between the different manoeuvres, whether performed in isometric or isokinetic modality (r: 0.60-0.94).

  9. Predictive force programming in the grip-lift task: the role of memory links between arbitrary cues and object weight.

    Science.gov (United States)

    Ameli, Mitra; Dafotakis, Manuel; Fink, Gereon R; Nowak, Dennis A

    2008-01-01

    We tested the ability of healthy participants to learn an association between arbitrary sensory cues and the weight of an object to be lifted using a precision grip between the index finger and thumb. Right-handed participants performed a series of grip-lift tasks with each hand. In a first experiment, participants lifted two objects of equal visual appearance which unexpectedly and randomly changed their weight. In two subsequent experiments, the change in object weight was indicated by cues, which were presented (i) visually or (ii) auditorily. When no cue about the weight of the object to be lifted was presented, participants programmed grip force according to the most recent lift, regardless of the hand used. In contrast, participants were able to rapidly establish an association between a particular sensory cue with a given weight and scaled grip force precisely to the actual weight thereafter, regardless of the hand used or the sensory modality of the cue. We discuss our data within the theoretical concept of internal models.

  10. An Overview on Gripping Force Measurement at the Micro and Nano-Scales Using Two-Fingered Microrobotic Systems

    Directory of Open Access Journals (Sweden)

    Mokrane Boudaoud

    2014-03-01

    Full Text Available Two-fingered micromanipulation systems with an integrated force sensor are widely used in robotics to sense and control gripping forces at the micro and nano-scales. They became of primary importance for an efficient manipulation and characterization of highly deformable biomaterials and nanostructures. This paper presents a chronological overview of gripping force measurement using two-fingered micromanipulation systems. The work summarizes the major achievements in this field from the early 90s to the present, focusing in particular on the evolution of measurement technologies regarding the requirements of microrobotic applications. Measuring forces below the microNewton for the manipulation of highly deformable materials, embedding force sensors within microgrippers to increase their dexterity, and reducing the influence of noise to improve the measurement resolution are among the addressed challenges. The paper shows different examples of how these challenges have been addressed. Resolution, operating range and signal/noise ratio of gripping force sensors are reported and compared. A discussion about force measurement technologies and gripping force control is performed and future trends are highlighted.

  11. Grip-Pattern Recognition in Smart Gun Based on Likelihood-Ratio Classifier and Support Vector Machine

    NARCIS (Netherlands)

    Shang, Xiaoxin; Veldhuis, Raymond N.J.

    2008-01-01

    In the biometric verification system of a smart gun, the rightful user of a gun is recognized based on grip-pattern recognition. It was found that the verification performance of this system degrades strongly when the data for training and testing have been recorded in different sessions with a time

  12. The Effect of Repetitive Rhythmic Precision Grip Task-Oriented Rehabilitation in Chronic Stroke Patients: A Pilot Study

    Science.gov (United States)

    Dispa, Delphine; Lejeune, Thierry; Thonnard, Jean-Louis

    2013-01-01

    Most chronic stroke patients present with difficulty in the manipulation of objects. The aim of this study was to test whether an intensive program of precision grip training could improve hand functioning of patients at more than 6 months after a stroke. This was a cross-over study; hence, at inclusion, the patients were randomly divided into two…

  13. An Overview on Gripping Force Measurement at the Micro and Nano-scales Using Two-fingered Microrobotic Systems

    Directory of Open Access Journals (Sweden)

    Mokrane Boudaoud

    2014-03-01

    Full Text Available Two-fingered micromanipulation systems with an integrated force sensor are widely used in robotics to sense and control gripping forces at the micro and nano-scales. They became of primary importance for an efficient manipulation and characterization of highly deformable biomaterials and nanostructures. This paper presents a chronological overview of gripping force measurement using two-fingered micromanipulation systems. The work summarizes the major achievements in this field from the early 90s to the present, focusing in particular on the evolution of measurement technologies regarding the requirements of microrobotic applications. Measuring forces below the microNewton for the manipulation of highly deformable materials, embedding force sensors within microgrippers to increase their dexterity, and reducing the influence of noise to improve the measurement resolution are among the addressed challenges. The paper shows different examples of how these challenges have been addressed. Resolution, operating range and signal/noise ratio of gripping force sensors are reported and compared. A discussion about force measurement technologies and gripping force control is performed and future trends are highlighted.

  14. The coefficient of variation as a measure of sincerity of effort of grip strength, Part II: sensitivity and specificity.

    Science.gov (United States)

    Shechtman, O

    2001-01-01

    The coefficient of variation (CV) is commonly used to detect sincerity of effort. The purpose of this study was to examine whether the CV possessed adequate sensitivity and specificity to effectively detect sincerity of effort of grip strength. One hundred forty-six uninjured volunteers underwent a series of grip strength tests. Sensitivity and specificity values were calculated for various CV cut-off values (between 2.5% and 22%) of the static grip test. The receiver operating characteristic (ROC) curves based on these values demonstrated the trade-offs between specificity and sensitivity. For example, the "traditional" 15% cut-off value yielded poor sensitivity (0.55), whereas the 11% cut-off value yielded poor specificity (0.74). Selecting any cut-off value along the continuum did not provide adequate sensitivity or specificity for labeling an effort sincere or insincere. Although the CV differentiated between maximal and submaximal effort, it was not sensitive or specific enough to do so effectively. Thus, the CV should not be used to assess sincerity of effort of grip strength.

  15. Synaptic and functional linkages between spinal premotor interneurons and hand-muscle activity during precision grip

    Directory of Open Access Journals (Sweden)

    Tomohiko eTakei

    2013-04-01

    Full Text Available Grasping is a highly complex movement that requires the coordination of a number of hand joints and muscles. Previous studies showed that spinal premotor interneurons (PreM-INs in the primate cervical spinal cord have divergent synaptic effects on hand motoneurons and that they might contribute to hand-muscle synergies. However, the extent to which these PreM-IN synaptic connections functionally contribute to modulating hand-muscle activity is not clear. In this paper, we explored the contribution of spinal PreM-INs to hand-muscle activation by quantifying the synaptic linkage (SL and functional linkage (FL of the PreM-INs with hand-muscle activities. The activity of 23 PreM-INs was recorded from the cervical spinal cord (C6–T1, with EMG signals measured simultaneously from hand and arm muscles in two macaque monkeys performing a precision grip task. Spike-triggered averages (STAs of rectified EMGs were compiled for 456 neuron–muscle pairs; 63 pairs showed significant post-spike effects (i.e., SL. Conversely, 231 of 456 pairs showed significant cross-correlations between the IN firing rate and rectified EMG (i.e., FL. Importantly, a greater proportion of the neuron–muscle pairs with SL showed FL (43/63 pairs, 68% compared with the pairs without SL (203/393, 52%, and the presence of SL was significantly associated with that of FL. However, a significant number of pairs had SL without FL (SL∩!FL, n = 20 or FL without SL (!SL∩FL, n = 203, and the proportions of these incongruities exceeded the number expected by chance. These results suggested that spinal PreM-INs function to significantly modulate hand-muscle activity during precision grip, but the contribution of other neural structures is also needed to recruit an adequate combination of hand-muscle motoneurons.

  16. Fabric along the NEEM ice core, Greenland, and its comparison with GRIP and NGRIP ice cores

    Science.gov (United States)

    Montagnat, M.; Azuma, N.; Dahl-Jensen, D.; Eichler, J.; Fujita, S.; Gillet-Chaulet, F.; Kipfstuhl, S.; Samyn, D.; Svensson, A.; Weikusat, I.

    2014-07-01

    Fabric (distribution of crystallographic orientations) along the full NEEM ice core, Greenland was measured in the field by an automatic ice texture analyzer every 10 m, from 33 m down to 2461 m depth. The fabric evolves from a slightly anisotropic fabric at the top, toward a strong single maximum at about 2300 m, which is typical of a deformation pattern mostly driven by uniaxial compression and simple shearing. A sharp increase in the fabric strengthening rate is observed at the Holocene to Wisconsin (HW) climatic transition. From a simple model we estimate that this depth is located at a transition from a state dominated by vertical compression to a state dominated by vertical shear. Comparisons are made to two others ice cores drilled along the same ridge; the GRIP ice core, drilled at the summit of the ice sheet, and the NGRIP ice core, drilled 325 km to the NNW of the summit along the ridge, and 365 km upstream from NEEM. This comparison tends to demonstrate that the ice viscosity change with the HW climatic transition must be associated with the shear-dominated state to induce the abrupt fabric strengthening observed at NEEM. This comparison therefore reflects the increasing role of shear deformation on the coring site when moving NW along the ridge from GRIP to NGRIP and NEEM. The difference in fabric profiles between NEEM and NGRIP also evidences a stronger lateral extension associated with a sharper ridge at NGRIP. Further along the core, centimeter scale abrupt texture (fabric and microstructure) variations are observed in the bottom part of the core. Their positions are in good agreement with the observed folding layers in Dahl-Jensen et al. (2013).

  17. Size-weight illusion and anticipatory grip force scaling following unilateral cortical brain lesion.

    Science.gov (United States)

    Li, Yong; Randerath, Jennifer; Goldenberg, Georg; Hermsdörfer, Joachim

    2011-04-01

    The prediction of object weight from its size is an important prerequisite of skillful object manipulation. Grip and load forces anticipate object size during early phases of lifting an object. A mismatch between predicted and actual weight when two different sized objects have the same weight results in the size-weight illusion (SWI), the small object feeling heavier. This study explores whether lateralized brain lesions in patients with or without apraxia alter the size-weight illusion and impair anticipatory finger force scaling. Twenty patients with left brain damage (LBD, 10 with apraxia, 10 without apraxia), ten patients with right brain damage (RBD), and matched control subjects lifted two different-sized boxes in alternation. All subjects experienced a similar size-weight illusion. The anticipatory force scaling of all groups was in correspondence with the size cue: higher forces and force rates were applied to the big box and lower forces and force rates to the small box during the first lifts. Within few lifts, forces were scaled to actual object weight. Despite the lack of significant differences at group level, 5 out of 20 LBD patients showed abnormal predictive scaling of grip forces. They differed from the LBD patients with normal predictive scaling by a greater incidence of posterior occipito-parietal lesions but not by a greater incidence of apraxia. The findings do not support a more general role for the motor-dominant left hemisphere, or an influence of apraxia per se, in the scaling of finger force according to object properties. However, damage in the vicinity of the parietal-occipital junction may be critical for deriving predictions of weight from size.

  18. Hand Grip Strength and Myocardial Oxygen Consumption Index among Coronary Artery Bypass Grafting Patients

    Directory of Open Access Journals (Sweden)

    Siti Nur Baait Biniti Mohd Sokran

    2015-07-01

    Full Text Available Background: Hand grip strength (HGS is a reliable indicator of peripheral muscle strength. Although, numerous studies have investigated the strength of hand grip; little attention has been given to coronary artery disease (CAD patients, exploring the relationship between HGS and myocardial oxygen consumption (MVO2 index. The current study aimed to evaluate the interaction between HGS and MVO2 index findings before and after cardiac surgery. Methods: Twenty-seven patients with CAD had HGS were assessed using handheld dynamometer. HGS for each hand were documented. MVO2 index was assessed using rate pressure product (RPP, which is the product of the heart rate (HR and systolic blood pressure (SBP. Repeated measures MANOVA were carried out to estimate the interaction between both hands HGS and MVO2 index before and after surgery. Results: There was significant interactions (P<0.001 for both HGS dominant and non-dominant with large effect sizes (HGS dominant×MVO2 index: hp2=0.44; HGS dominant×RPP: hp2=0.49. This signifies that peripheral muscle strength of the upper limb (HGS dominant and non-dominant had different effects on MVO2 index before and after surgery. The interaction graph shows that the increase in MVO2 index after surgery was significantly greater for peripheral muscle strength of the dominant hand when compared to non-dominant. Conclusion: Patients with CAD had interactions between HGS and oxygen consumption before and after surgery. Hence, HGS might be used as a predictor to assess oxygen consumption among cardiac patients.

  19. Multicentric observational study of pain after the use of a self-gripping lightweight mesh.

    Science.gov (United States)

    García Ureña, M Á; Hidalgo, M; Feliu, X; Velasco, M Á; Revuelta, S; Gutiérrez, R; Utrera, A; Porrero, J L; Marín, M; Zaragoza, C

    2011-10-01

    Investigation in the field of inguinal hernia surgery is now focused on postoperative pain. The extended use of lightweight meshes and alternative methods of fixation may play a relevant role in the reduction of pain. In this study, a new self-gripping lightweight polypropylene mesh is tested. A multicentric, observational study was scheduled to prospectively evaluate this new mesh. Ten centers agreed to participate. Only primary, type 1 or 2 uncomplicated hernias in adults were included. The mesh was placed as a Lichtenstein procedure without any fixation. A complete pain questionnaire was followed at 1 week, and at 1, 3 and 6 months postoperatively. The principal goal of the study was to evaluate maximum pain score at 6 months. Pain was assessed by a visual analog scale. A total of 256 patients were operated. Mean operative time was 35.6 min; 76.2% of patients were operated in an ambulatory setting. There were a few postoperative complications: 2 wound infections, 17 seromas, 21 hematomas, 6 orchitis. The incidence of acute pain was 27.3% at week 1 and 7.5% at month 1. The incidence of chronic pain was 3.6% at month 3 and 2.8% at month 6. No recurrences or long-term complications were observed. This self-gripping mesh can be used safely in type 1 and 2 primary, uncomplicated inguinal hernia with minimal morbidity and most patients under ambulatory setting. The registered incidence of chronic pain is lower than 3%.

  20. Feasibility of an Assessment Tool for Children's Competence to Consent to Predictive Genetic Testing: a Pilot Study.

    Science.gov (United States)

    Hein, Irma M; Troost, Pieter W; Lindeboom, Robert; Christiaans, Imke; Grisso, Thomas; van Goudoever, Johannes B; Lindauer, Ramón J L

    2015-12-01

    Knowledge on children's capacities to consent to medical treatment is limited. Also, age limits for asking children's consent vary considerably between countries. Decision-making on predictive genetic testing (PGT) is especially complicated, considering the ongoing ethical debate. In order to examine just age limits for alleged competence to consent in children, we evaluated feasibility of a standardized assessment tool, and investigated cutoff ages for children's competence to consent to PGT. We performed a pilot study, including 17 pediatric outpatients between 6 and 18 years at risk for an autosomal dominantly inherited cardiac disease, eligible for predictive genetic testing. The reference standard for competence was established by experts trained in the relevant criteria for competent decision-making. The MacArthur Competence Assessment Tool for Treatment (MacCAT-T) served as index test. Data analysis included raw agreement between competence classifications, difference in mean ages between children judged competent and judged incompetent, and estimation of cutoff ages for judgments of competence. Twelve (71 %) children were considered competent by the reference standard, and 16 (94 %) by the MacCAT-T, with an overall agreement of 76 %. The expert judgments disagreed in most cases, while the MacCAT-T judgments agreed in 65 %. Mean age of children judged incompetent was 9.3 years and of children judged competent 12.1 years (p = .035). With 90 % sensitivity, children younger than 10.0 years were judged incompetent, with 90 % specificity children older than 11.8 years were judged competent. Feasibility of the MacCAT-T in children is confirmed. Initial findings on age cutoffs are indicative for children between the age of 12 and 18 to be judged competent for involvement in the informed consent process. Future research on appropriate age-limits for children's alleged competence to consent is needed.

  1. Application of New Yoke Plate Wire Grip for Transmission Line in Maintenance%输电线路用新型联板紧线器在检修工作中的应用

    Institute of Scientific and Technical Information of China (English)

    郑浩; 廖志斌; 李德波; 于启万

    2015-01-01

    Combined with the present situation of the maintenance of twin insulator strings of transmission line, the problems of the wire grip in the maintenance work are discussed , aiming at proposing a mainte-nance tactics to replace the twin insulator strings of 110kV and over transmission line tower , and resolving the problem of just using tool to fasten yoke plate , and a kind of wire grip which can fasten two yoke plates and string is researched .%结合输电线路双联串绝缘子检修现状,对输电线路检修工作中的紧线器存在的问题进行了探讨,旨在提出一种用于更换110千伏及以上输电线路杆塔双联串绝缘子的检修策略,解决使用工具单独固定联板的难题,并研究一种可以固定两个联板然后进行紧线的紧线器工具。

  2. The development of a methodology to determine the relationship in grip size and pressure to racket head speed in a tennis forehand stroke

    DEFF Research Database (Denmark)

    Christensen, Jonas; Rasmussen, John; Halkon, Ben;

    2016-01-01

    This study developed a methodology to examine the effects of grip size and grip firmness on the kinematic contribution of angular velocity (KCAV) to the generation of racket head speed during a topspin tennis forehand. The KCAV is subdivided into kinematic contribution of joint angular velocity...... and kinematic contribution of the body segments in the upper trunk translational and angular velocities. Two Babolat Pure Storm GT rackets, with grip sizes 2 and 4 respectively, were used with Tekscan 9811E pressure sensors applied to the handles to examine pressure distribution during the stroke. Upper body...

  3. A method to study precision grip control in viscoelastic force fields using a robotic gripper.

    Science.gov (United States)

    Lambercy, Olivier; Metzger, Jean-Claude; Santello, Marco; Gassert, Roger

    2015-01-01

    Instrumented objects and multipurpose haptic displays have commonly been used to investigate sensorimotor control of grasping and manipulation. A major limitation of these devices, however, is the extent to which the experimenter can vary the interaction dynamics to fully probe sensorimotor control mechanisms. We propose a novel method to study precision grip control using a grounded robotic gripper with two moving, mechanically coupled finger pads instrumented with force sensors. The device is capable of stably rendering virtual mechanical properties with a wide dynamic range of achievable impedances. Eight viscoelastic force fields with different combinations of stiffness and damping parameters were implemented, and tested on eight healthy subjects performing 30 consecutive repetitions of a grasp, hold, and release task with time and position constraints. Rates of thumb and finger force were found to be highly correlated (r>0.9) during grasping, revealing that, despite the mechanical coupling of the two finger pads, subjects performed grasping movements in a physiological fashion. Subjects quickly adapted to the virtual dynamics (within seven trials), but, depending on the presented force field condition, used different control strategies to correctly perform the task. The proof of principle presented in this paper underscores the potential of such a one-degree-of-freedom robotic gripper to study neural control of grasping, and to provide novel insights on sensorimotor control mechanisms.

  4. Reconstructed animation from four-phase grip MRI of the wrist with ulnar-sided pain.

    Science.gov (United States)

    Oda, T; Wada, T; Iba, K; Aoki, M; Tamakawa, M; Yamashita, T

    2013-09-01

    In order to visualize dynamic variations related to ulnar-sided wrist pain, animation was reconstructed from T2* coronal-sectioned magnetic resonance imaging in each of the four phases of grip motion for nine wrists in patients with ulnar pain. Eight of the nine wrists showed a positive ulnar variance of less than 2 mm. Ulnocarpal impaction and triangular fibrocartilage complex injury were assessed on the basis of animation and arthroscopy, respectively. Animation revealed ulnocarpal impaction in four wrists. In one of the four wrists, the torn portion of the articular disc was impinged between the ulnar head and ulnar proximal side of the lunate. In another wrist, the ulnar head impacted the lunate directly through the defect in the articular disc that had previously been excised. An ulnar shortening osteotomy successfully relieved ulnar wrist pain in all four cases with both ulnocarpal impaction and Palmer's Class II triangular fibrocartilage complex tears. This method demonstrated impairment of the articular disc and longitudinal instability of the distal radioulnar joint simultaneously and should be of value in investigating dynamic pathophysiology causing ulnar wrist pain.

  5. Analysis of fatigue and tremor during sustained maximal grip contractions using Hilbert-Huang Transformation.

    Science.gov (United States)

    Li, Ke; Hogrel, Jean-Yves; Duchêne, Jacques; Hewson, David J

    2012-09-01

    The objective of this study was to evaluate muscle fatigue and tremor during a Sustained Maximal Grip Contraction (SMGC) using the Hilbert-Huang Transformation (HHT). Thirty-nine healthy subjects volunteered for the study and performed a 25-s SMGC. Fatigue parameters such as the relative force output (RFO) were calculated from the residual of SMGC after applying Empirical Mode Decomposition (EMD). Using the energy spectrum of the Intrinsic Mode Functions (IMF) obtained using HHT, isometric force tremor was identified from the 4 to 12 Hz region in IMF3 and IMF4. Data were analysed for five consecutive 5-s epochs to identify changes in fatigue and tremor over time. The HHT method was able to identify a greater resistance to fatigue in women compared to men (p≤0.05) and in non-dominant hands compared to dominant hands (p≤0.05). Consistent with the results for fatigue, women had less tremor than men (p≤0.05), while non-dominant hands trembled less than did dominant hands (p≤0.05). Higher levels of tremor were observed for non-fatigue-resistant subjects for both 10-15 s and 15-20 s epochs (p≤0.05). The HHT is an appropriate method to identify both fatigue and tremor during SMGC. It would be of interest to apply this method to the study the elderly or patients with neuromuscular disorders.

  6. Public perceptions of a rip current hazard education program: "Break the Grip of the Rip!"

    Science.gov (United States)

    Houser, Chris; Trimble, Sarah; Brander, Robert; Brewster, B. Chris; Dusek, Greg; Jones, Deborah; Kuhn, John

    2017-07-01

    Rip currents pose a major global beach hazard; estimates of annual rip-current-related deaths in the United States alone range from 35 to 100 per year. Despite increased social research into beach-goer experience, little is known about levels of rip current knowledge within the general population. This study describes the results of an online survey to determine the extent of rip current knowledge across the United States, with the aim of improving and enhancing existing beach safety education material. Results suggest that the US-based Break the Grip of the Rip!® campaign has been successful in educating the public about rip current safety directly or indirectly, with the majority of respondents able to provide an accurate description of how to escape a rip current. However, the success of the campaign is limited by discrepancies between personal observations at the beach and rip forecasts that are broadcasted for a large area and time. It was the infrequent beach user that identified the largest discrepancies between the forecast and their observations. Since infrequent beach users also do not seek out lifeguards or take the same precautions as frequent beach users, it is argued that they are also at greatest risk of being caught in a dangerous situation. Results of this study suggest a need for the national campaign to provide greater focus on locally specific and verified rip forecasts and signage in coordination with lifeguards, but not at the expense of the successful national awareness program.

  7. Detecting submaximal efforts in grip strength testing with the coefficient of variation.

    Science.gov (United States)

    Robinson, M E; Geisser, M E; Hanson, C S; O'Connor, P D

    1993-03-01

    The use of the coefficient of variation (CV) to determine level of effort in grip strength testing was examined empirically. Twenty-nine asymptomatic subjects participated in two conditions of testing: 100% effort and 50% effort. Order of conditions was counterbalanced and each subject was run in both conditions twice in the same order in order to assess the stability of the method. The number of trials (grasps) per condition was three for a total of 12 grasps for the study. The submaximal (50%) effort condition showed significantly more variability than the maximal effort condition in both sets of conditions (p<.01). Intra-class correlation coefficients were very low for both maximal effort and submaximal efforts (.036 and .025) indicating very low stability for the coefficient of variation. Classification rates were also found to have unacceptably large errors with 69% of the submaximal efforts being classified as maximal with the traditional 15% CV cutoff and 55% misclassification of submaximal efforts with an optimized 11% CV cutoff. It was concluded that the currently practiced method of using a low number of repetitions to calculate the CV may result in very unstable measures. Furthermore the "false negative" rate in using this method is unacceptably high for practical application. The implications of using the method and suggestions for improvement are discussed.

  8. Low serum selenium concentrations are associated with poor grip strength among older women living in the community

    OpenAIRE

    2007-01-01

    Aging is associated with a loss of muscle strength, and, in turn, loss of muscle strength has been associated with increased risk of frailty, disability and mortality. The factors that contribute to loss of muscle strength with aging have not been well characterized. Selenium is important in normal muscle function because of its role in selenoenzymes that protect muscle against oxidative damage. We hypothesized that low serum selenium concentrations were associated with poor grip strength. We...

  9. Key Insights into Hand Biomechanics: Human Grip Stiffness Can Be Decoupled from Force by Cocontraction and Predicted from Electromyography

    Directory of Open Access Journals (Sweden)

    Hannes Höppner

    2017-05-01

    Full Text Available We investigate the relation between grip force and grip stiffness for the human hand with and without voluntary cocontraction. Apart from gaining biomechanical insight, this issue is particularly relevant for variable-stiffness robotic systems, which can independently control the two parameters, but for which no clear methods exist to design or efficiently exploit them. Subjects were asked in one task to produce different levels of force, and stiffness was measured. As expected, this task reveals a linear coupling between force and stiffness. In a second task, subjects were then asked to additionally decouple stiffness from force at these force levels by using cocontraction. We measured the electromyogram from relevant groups of muscles and analyzed the possibility to predict stiffness and force. Optical tracking was used for avoiding wrist movements. We found that subjects were able to decouple grip stiffness from force when using cocontraction on average by about 20% of the maximum measured stiffness over all force levels, while this ability increased with the applied force. This result contradicts the force–stiffness behavior of most variable-stiffness actuators. Moreover, we found the thumb to be on average twice as stiff as the index finger and discovered that intrinsic hand muscles predominate our prediction of stiffness, but not of force. EMG activity and grip force allowed to explain 72 ± 12% of the measured variance in stiffness by simple linear regression, while only 33 ± 18% variance in force. Conclusively the high signal-to-noise ratio and the high correlation to stiffness of these muscles allow for a robust and reliable regression of stiffness, which can be used to continuously teleoperate compliance of modern robotic hands.

  10. Key Insights into Hand Biomechanics: Human Grip Stiffness Can Be Decoupled from Force by Cocontraction and Predicted from Electromyography

    Science.gov (United States)

    Höppner, Hannes; Große-Dunker, Maximilian; Stillfried, Georg; Bayer, Justin; van der Smagt, Patrick

    2017-01-01

    We investigate the relation between grip force and grip stiffness for the human hand with and without voluntary cocontraction. Apart from gaining biomechanical insight, this issue is particularly relevant for variable-stiffness robotic systems, which can independently control the two parameters, but for which no clear methods exist to design or efficiently exploit them. Subjects were asked in one task to produce different levels of force, and stiffness was measured. As expected, this task reveals a linear coupling between force and stiffness. In a second task, subjects were then asked to additionally decouple stiffness from force at these force levels by using cocontraction. We measured the electromyogram from relevant groups of muscles and analyzed the possibility to predict stiffness and force. Optical tracking was used for avoiding wrist movements. We found that subjects were able to decouple grip stiffness from force when using cocontraction on average by about 20% of the maximum measured stiffness over all force levels, while this ability increased with the applied force. This result contradicts the force–stiffness behavior of most variable-stiffness actuators. Moreover, we found the thumb to be on average twice as stiff as the index finger and discovered that intrinsic hand muscles predominate our prediction of stiffness, but not of force. EMG activity and grip force allowed to explain 72 ± 12% of the measured variance in stiffness by simple linear regression, while only 33 ± 18% variance in force. Conclusively the high signal-to-noise ratio and the high correlation to stiffness of these muscles allow for a robust and reliable regression of stiffness, which can be used to continuously teleoperate compliance of modern robotic hands. PMID:28588472

  11. The use of the rapid exchange grip test in detecting sincerity of effort, Part II: validity of the test.

    Science.gov (United States)

    Shechtman, O; Taylor, C

    2000-01-01

    The rapid exchange grip (REG) test was developed to identify patients exerting insincere effort. The premise of the REG test is that a maximal, sincere effort yields a "negative REG," in which peak static grip (SG) scores are greater than peak REG scores, and that a submaximal, insincere effort yields a "positive REG," in which REG scores are greater than SG scores. There is disagreement in the literature concerning what constitutes a positive REG test, suggesting that the REG may not be a valid measure of sincerity of effort. The purpose of the present study was to investigate the validity of the REG test by examining its premise as well as its sensitivity and specificity values. The 146 uninjured subjects performed a series of randomized grip strength tests, exerting both maximal and submaximal efforts. The tests included the REG at hand switch rates of 45 rpm (REG-45) and 60 rpm (REG-60), the maximal static grip test (MSGT), and the five-rung test (5R). Our findings supported the concept of a "negative REG" for both REG maneuvers and both comparative SG tests. The concept of a "positive REG," however, was supported only when peak REG scores were compared with peak 5R scores. The authors found relatively low sensitivity and specificity values, suggesting that the REG test may not be sensitive or specific enough to effectively detect sincerity of effort. The authors discuss the likelihood that mistakes will be made when the REG test is used to diagnose sincerity of effort and the possible consequences of making such mistakes.

  12. Lipodystrophy and inflammation predict later grip strength in HIV-infected men: the MACS Body Composition substudy.

    Science.gov (United States)

    Crawford, Keith W; Li, Xiuhong; Xu, Xiaoqiang; Abraham, Alison G; Dobs, Adrian S; Margolick, Joseph B; Palella, Frank J; Kingsley, Lawrence A; Witt, Mallory D; Brown, Todd T

    2013-08-01

    Body fat changes in HIV-infected persons are associated with increased systemic inflammation and increased mortality. It is unknown whether lipodystrophy is also associated with declines in physical function. Between 2001 and 2003, 33 HIV-infected men with evidence of lipodystrophy (LIPO⁺), 23 HIV-infected men without lipodystrophy (LIPO⁻), and 33 seronegative men were recruited from the Multicenter AIDS Cohort Study (MACS) for the Body Composition substudy. Visceral adipose tissue (VAT) was assessed by quantitative computed tomography. Lean body mass (LBM) and extremity fat were measured by dual-energy x-ray absorptiometry. Insulin resistance was estimated by Homeostatic Model Assessment (HOMA). Serum interleukin (IL)-6, soluble tumor necrosis factor (TNF)-α receptors I and II (sTNFRI and sTNFRII), and highly sensitive C-reactive protein (hs-CRP) concentrations were quantified from archived serum samples. These measurements were correlated with grip strength measured in 2007 using linear regression. At the substudy visit, the LIPO⁺ group had higher HOMA, sTNFRI, sTNFRII, and IL-6 levels than the LIPO⁻ group. In 2007, the LIPO⁺ group had lower median grip strength than the LIPO⁻ group (34.4 vs. 42.7 kg, p=0.002). Multivariable analysis of HIV⁺ men showed older age, lower LBM, higher sTNFRII concentrations, and LIPO⁺ status [adjusted mean difference -4.9 kg (p=0.045)] at the substudy visit were independently associated with lower subsequent grip strength. Inflammation, lower LBM, and lipodystrophy in HIV-infected men were associated with lower subsequent grip strength. These findings suggest that inflammation may contribute to declines in functional performance, independent of age.

  13. Effects of intermanual transfer induced by repetitive precision grip on input-output properties of untrained contralateral limb muscles.

    Science.gov (United States)

    Liang, Nan; Takahashi, Makoto; Ni, Zhen; Yahagi, Susumu; Funase, Kozo; Kato, Takashi; Kasai, Tatsuya

    2007-10-01

    Although there were many reports relating to intermanual transfer of behavioral motor tasks in humans, it is still not well-known whether the transfer phenomenon between the trained and untrained hand is accompanied by corresponding changes in motor system. In the present study we applied transcranial magnetic stimulation to investigate the practice effects of unilateral fingertip precision grip on corticospinal excitability, regarding both the trained and untrained hand muscles. The results showed that after practice fingertip grip force became steady and safety margin dramatically decreased not only in the trained hand, but also in the untrained hand. Regarding MEP and background EMG (B.EMG) activities, the regression slope of MEP/B.EMG ratio in the first dorsal interosseous (FDI) muscle became significantly steeper after practice in both hands, but in the thenar (TH) muscle there were no clear modulations. These results indicated that through practice qualitative or functional changes of corticospinal systems related to the reorganization for a fingertip precision grip prominently reflect only on FDI muscle which plays a dominant role in the task. More importantly, such effects were simultaneously seen in the untrained hand correspondent to the trained hand, i.e., changes of input-output property in M1 occur not only in the trained hand, but also in the untrained hand. Based on the present results, we suggest that training-induced neural adaptations of the central nervous system may include improvement of its predicting fingertip grip force for self-lifting of the object in the untrained hand.

  14. Effect of range of motion and isometric strengthening exercises on grip strength and hand function in rheumatoid arthritis patients

    Directory of Open Access Journals (Sweden)

    Yefta Daniel Bastiana

    2016-04-01

    Full Text Available In previous studies, duration of hand exercises in patients with rheumatoid arthritis (RA had widely varying ranges, from 3 weeks to 4 months. An experimental study was conducted to evaluate the effect of range of motion (ROM and muscle strengthening exercises for 6 weeks on grip strength and hand function in RA patients. Seventeen patients with chronic RA were randomly assigned to a treatment group and a control group. The treatment group (n=8 was given muscle strengthening exercises and heat therapy using paraffin baths 3 times a week at the hospital and ROM exercises once a day at home for 6 weeks. The control group (n=9 was given only paraffin baths 3 times a week. After 6 weeks, there were significant differences in hand function (p=0.003, right and left grip strength (p=0.000 and p=0.001 and ROM in the interventional group only. ROM and isometric strengthening exercises significantly improved grip strength and hand function in patients with RA, while no impact was found when the patients were given paraffin baths only. In view of the small size of the study population, there is a need for further studies with larger populations.

  15. Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats.

    Science.gov (United States)

    Xue, Qian-Li; Yang, Huanle; Li, Hui-Fen; Abadir, Peter M; Burks, Tyesha N; Koch, Lauren G; Britton, Steven L; Carlson, Joshua; Chen, Laura; Walston, Jeremy D; Leng, Sean X

    2016-04-01

    Rapamycin is known to extend lifespan. We conducted a randomized placebo-controlled study of enteric rapamycin-treatment to evaluate its effect on physical function in old low capacity runner (LCR) rats, a rat model selected from diverse genetic background for low intrinsic aerobic exercise capacity without genomic manipulation and characterized by increased complex disease risks and aging phenotypes. The study was performed in 12 male and 16 female LCR rats aged 16-22 months at baseline. The treatment group was fed with rapamycin-containing diet pellets at approximately 2.24mg/kg body weight per day and the placebo group with the same diet without rapamycin for six months. Observation was extended for additional 2 months. Physical function measurements include grip strength measured as maximum tensile force using a rat grip strength meter and maximum running distance (MRD) using rat physical treadmill test. The results showed that rapamycin improved grip strength by 13% (p=.036) and 60% (p=.001) from its baseline in female and male rats, respectively. Rapamycin attenuated MRD decline by 66% (p=.001) and 46% (p=.319) in females and males, respectively. These findings provide initial evidence for beneficial effect of rapamycin on physical functioning in an aging rat model of high disease risks with significant implication in humans.

  16. Drivers’ Interaction with Adaptive Cruise Control on Dry and Snowy Roads with Various Tire-Road Grip Potentials

    Directory of Open Access Journals (Sweden)

    Ioana Koglbauer

    2017-01-01

    Full Text Available This study investigates drivers’ interaction with Adaptive Cruise Control (ACC in different road conditions and identifies areas of improvement. Ninety-six drivers drove with the ACC in a driving simulator showing either a summer scenery and a dry road with high grip potential or a winter scenery with a snowy road and reduced grip potential. The results show that on snowy roads the drivers set in average a lower ACC speed and preferred a larger ACC time gap. Drivers’ workload and effort were higher when using the ACC on snowy as compared to dry roads. Generally, the use of a shorter ACC gap resulted in lower ratings of comfort, safety, and trust and higher ratings of mental workload and effort in both dry and snowy road conditions. The drivers judged that ACC was braking too late and maintained a too short gap to the forward vehicle, especially when the ACC was set to 1 second as compared to a 1.8-second time gap. A future adaptation of ACC’s control strategy to reduced tire-road grip potential would not only improve comfort and user acceptance of the human driver but also increase the potential to react in emergency situations with braking or evasive steering.

  17. Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

    Science.gov (United States)

    Takeshita, Hikari; Yamamoto, Koichi; Nozato, Satoko; Inagaki, Tadakatsu; Tsuchimochi, Hirotsugu; Shirai, Mikiyasu; Yamamoto, Ryohei; Imaizumi, Yuki; Hongyo, Kazuhiro; Yokoyama, Serina; Takeda, Masao; Oguro, Ryosuke; Takami, Yoichi; Itoh, Norihisa; Takeya, Yasushi; Sugimoto, Ken; Fukada, So-ichiro; Rakugi, Hiromi

    2017-01-01

    The conventional forelimb grip strength test is a widely used method to assess skeletal muscle function in rodents; in this study, we modified this method to improve its variability and consistency. The modified test had lower variability among trials and days than the conventional test in young C57BL6 mice, especially by improving the variabilities in male. The modified test was more sensitive than the conventional test to detect a difference in motor function between female and male mice, or between young and old male mice. When the modified test was performed on male mice during the aging process, reduction of grip strength manifested between 18 and 24 months of age at the group level and at the individual level. The modified test was similar to the conventional test in detecting skeletal muscle dysfunction in young male dystrophic mice. Thus, the modified forelimb grip strength test, with its improved validity and reliability may be an ideal substitute for the conventional method. PMID:28176863

  18. Exposures and physiological responses in power tool operations: fastening vs. unfastening threaded hardware.

    Science.gov (United States)

    Lin, Jia-Hua; McGorry, Raymond W; Banks, Jacob J

    2010-05-01

    Powered hand tools have the potential to produce reaction forces that may be associated with upper extremity musculoskeletal disorders. This study examined and compared the kinetic and physiological impacts on operator upper extremities between the fastening and unfastening operations. Thirty-two healthy, right-handed male operators used four tools on two joint simulators at different working heights and distances in the laboratory. Three work configurations were simulated: pistol grip tools on a vertical and horizontal surface, and right angle tools on a horizontal surface. Grip force was measured on an instrumented handle attached to each tool. Muscle activity was monitored at the wrist flexor and extensor and the upper trapezius of the right arm. Paired comparisons showed that when pistol grip tools were used, the peak torque to unfasten a joint (3.7 Nm) was significantly less than to fasten the same joint (5.7 Nm). However, the exposure time was longer for unfastening cycles (98 ms more on the horizontal surface, and 107 ms more on the vertical surface). The average grip force scaled to corresponding peak tool torque revealed that the effort to react against torque was greater in unfastening cycles than in fastening cycles for all work configurations. It also showed that as a proximal stabilizer, the upper trapezius muscle had a greater activity in unfastening cycles. The kinetic and physiological responses demonstrated that unfastening fasteners, which has been neglected in the literature, have the potential to increase risk for musculoskeletal disorders and should be considered in ergonomics assessment in the workplace.

  19. Effect of anaemia on hand grip strength, walking speed, functionality and 1 year mortality in older hospitalized patients.

    Science.gov (United States)

    Joosten, Etienne; Detroyer, Elke; Milisen, Koen

    2016-08-19

    Anaemia is a common problem in hospitalized older patients and is recognized as a risk factor for a significant number of adverse outcomes. Data of the effect of anaemia on functional status during hospitalization and mortality after discharge are limited. Aim of the study is to examine whether there is an association between anaemia, hand grip strength, gait speed and basic activities of daily living (ADL) during hospitalization and mortality 1 year after discharge in geriatric patients. In a prospective study, data on age, sex, body mass index, Mini-Mental State Examination (MMSE), main clinical diagnosis, number of comorbidities, hand grip strength, gait speed, ADL, haemoglobin, C-reactive protein and estimated Glomerular filtration ratio (eGFR) were recorded in 220 older patients, admitted to the acute geriatric ward of a university hospital. Anaemia was defined as a haemoglobin level anaemia (haemoglobin between 10 and 12 g/dL for women and 10 and 13 g/dL for men). Gait speed (in meters per second) was calculated after a 4.5 m walk and hand grip strength (in kilogram) was assessed with a hydraulic hand dynamometer. Functionality was assessed in the six basic activities of daily living. Information about the vital status was obtained 1 year after discharge with a telephone call. Analysis of covariance (ANCOVA) was used to examine the effect of the anaemia status on the walking speed, hand grip strength and premorbid ADL index and logistic regression analysis was used to examine whether anaemia could be identified as risk factors for mortality 12 months after discharge. Overall, 106 (48 %) patients had anaemia. Hand-grip strength, gait speed and ADL score were not significantly different between anaemic and non-anaemic hospitalized geriatric patients. After adjustment for age, sex, body mass index, eGFR, MMSE, number of comorbidities and main clinical diagnosis, the means for hand-grip strength were 17.3, 19.9 and 19.1 kg (p = 0.38); for gait speed 0

  20. The Vacuum-Compacted Regolith Gripping Mechanism and Unmanned Flights via Quad-Rotors

    Science.gov (United States)

    Scott, Rollin L.

    2014-01-01

    During the course of the Kennedy Space Center Summer Internship, two main experiments were performed: The Vacuum-Compacted Regolith Gripping Mechanism and Unmanned Flights via Quad-copters. The objectives of the Vacuum-Compacted Regolith Gripping Mechanism, often abbreviated as the Granular Gripper, are to exhibit Space Technology, such as a soft robotic hand, lift different apparatuses used to excavate regolith, and conserve energy while executing its intended task. The project is being conducted to test how much weight the Granular Gripper can hold. With the use of an Animatronic Robotic Hand, Arduino Uno, and other components, the system was calibrated before actually conducting the intended weight test. The maximum weight each finger could hold with the servos running, in the order of pinky, ring, middle, and index fingers, are as follows: 1.340N, 1.456 N, 0.9579 N, and 1.358 N. Using the small vacuum pump system, the maximum weight each finger could hold, in the same order, was: 4.076 N, 6.159 N, 5.454 N, and 4.052 N. The maximum torques on each of the fingers when the servos were running, in the same respective order, was: 0.0777 Nm, 0.0533 Nm, 0.0648 Nm, and 0.0532 Nm. The maximum torques on the individual fingers, when the small vacuum pump was in effect, in the same order as above, was: 0.2318 Nm, 0.3032 Nm, 0.2741 Nm, and 0.1618 Nm. In testing all the fingers with the servos running, the total weight was 5.112 N and the maximum torque on the all the fingers was 0.2515 Nm. However, when the small vacuum pump system was used, the total weight was 19.741 N and the maximum torque on the all the fingers was 0.9713 Nm. The conclusion that was drawn stated that using the small vacuum pump system proved nearly 4 times more effective when testing how much weigh the hand could hold. The resistance provided by the compacted sand in the glove allowed more weight to be held by the hand and glove. Also, when the servos turned off and the hand still retaining its

  1. Self-organization, free energy minimization, and optimal grip on a field of affordances

    Directory of Open Access Journals (Sweden)

    Jelle eBruineberg

    2014-08-01

    Full Text Available In this paper, we set out to develop a theoretical and conceptual framework for the new field of Radical Embodied Cognitive Neuroscience. This framework should be able to integrate insights from several relevant disciplines: theory on embodied cognition, ecological psychology, phenomenology, dynamical systems theory, and neurodynamics. We suggest that the main task of Radical Embodied Cognitive Neuroscience is to investigate the phenomenon of skilled intentionality from the perspective of the self-organization of the brain-body-environment system, while doing justice to the phenomenology of skilled action. In previous work, we have characterized skilled intentionality as the organism’s tendency towards an optimal grip on multiple relevant affordances simultaneously. Affordances are possibilities for action provided by the environment. In the first part of this paper, we introduce the notion of skilled intentionality and the phenomenon of responsiveness to a field of relevant affordances. Second, we use Friston’s work on neurodynamics, but embed a very minimal version of his Free Energy Principle in the ecological niche of the animal. Thus amended, this principle is helpful for understanding the embeddedness of neurodynamics within the dynamics of the brain-body-environment system. Next, we show how we can use this adjusted principle to understand the neurodynamics of selective openness to the environment: interacting action-readiness patterns at multiple timescales contribute to the organism’s selective openness to relevant affordances. In the final part of the paper, we emphasize the important role of metastable dynamics in both the brain and the brain-body-environment system for adequate affordance-responsiveness. We exemplify our integrative approach by presenting research on the impact of Deep Brain Stimulation on affordance responsiveness of OCD patients.

  2. Self-organization, free energy minimization, and optimal grip on a field of affordances.

    Science.gov (United States)

    Bruineberg, Jelle; Rietveld, Erik

    2014-01-01

    In this paper, we set out to develop a theoretical and conceptual framework for the new field of Radical Embodied Cognitive Neuroscience. This framework should be able to integrate insights from several relevant disciplines: theory on embodied cognition, ecological psychology, phenomenology, dynamical systems theory, and neurodynamics. We suggest that the main task of Radical Embodied Cognitive Neuroscience is to investigate the phenomenon of skilled intentionality from the perspective of the self-organization of the brain-body-environment system, while doing justice to the phenomenology of skilled action. In previous work, we have characterized skilled intentionality as the organism's tendency toward an optimal grip on multiple relevant affordances simultaneously. Affordances are possibilities for action provided by the environment. In the first part of this paper, we introduce the notion of skilled intentionality and the phenomenon of responsiveness to a field of relevant affordances. Second, we use Friston's work on neurodynamics, but embed a very minimal version of his Free Energy Principle in the ecological niche of the animal. Thus amended, this principle is helpful for understanding the embeddedness of neurodynamics within the dynamics of the system "brain-body-landscape of affordances." Next, we show how we can use this adjusted principle to understand the neurodynamics of selective openness to the environment: interacting action-readiness patterns at multiple timescales contribute to the organism's selective openness to relevant affordances. In the final part of the paper, we emphasize the important role of metastable dynamics in both the brain and the brain-body-environment system for adequate affordance-responsiveness. We exemplify our integrative approach by presenting research on the impact of Deep Brain Stimulation on affordance responsiveness of OCD patients.

  3. Spinal interneurons facilitate coactivation of hand muscles during a precision grip task in monkeys.

    Science.gov (United States)

    Takei, Tomohiko; Seki, Kazuhiko

    2010-12-15

    Grasping is a highly complex movement requiring coordination of a number of hand joints and muscles. In contrast to cortical descending systems, the contribution of the subcortical system for coordinating this higher degree of freedom is largely unknown. Here we explore how spinal interneurons (INs) contribute to the coordination of hand muscles by recording their activity from the cervical spinal cord (C5-T1) simultaneously with electromyographic (EMG) activity from hand and arm muscles in three monkeys performing a precision grip task. Spike-triggered averages of the rectified EMGs were compiled for 255 neurons (4821 neuron-muscle pairs). Twenty-six neurons produced 68 significant postspike effects in hand and arm muscles and were identified as premotor interneurons (PreM-INs), which presumably have relatively direct synaptic effects on spinal motoneurons. The majority of the PreM-INs (22/26 neurons) produced postspike effects in finger muscles (intrinsic and extrinsic hand muscles) compared with wrist (9/26 neurons) and elbow muscles (1/26 neurons). The effects in finger muscles were mostly facilitative [postspike facilitations (PSFs), 19/22 neurons], and few had suppressive effects (postspike suppressions, 3/22 neurons). Moreover, PreM-INs produced more divergent PSFs in intrinsic hand muscles (2.5 ± 1.9 muscles/neuron) than in wrist muscles (1.2 ± 0.4 muscles/neurons). We conclude that spinal PreM-INs produce divergent facilitations preferentially in intrinsic hand muscles. These results suggest that spinal interneurons contribute to the control of hand grasping in primates by combining and coordinating multiple finger muscles.

  4. IMPACT OF COMBINING MIRROR THERAPY AND HABIT ON HAND GRIP STRENGTH IN CHILDREN WITH HEMIPARESIS

    Directory of Open Access Journals (Sweden)

    Asmaa A. Abo Nour

    2016-08-01

    Full Text Available Background: hemiparetic children usually tend to avoid the use of their impaired arm and are remarkably tend to perform inherently bimanual tasks of daily living with the less impaired arm only rather than with both arms. In fact, these children actually may have never learned to use their impaired arm for certain motor tasks or may only use it in the simplest manner, so the purpose of the study was to determine the impact of combining HABIT and mirror therapy on hand grip in hemiparetic children. Methods: A total of 30 hemiparetic children divided randomly into two groups (A and B of equal number, (N of each =15. Eligibility criteria to our study were age ranged from 4-8 years, ability to score more than 50 % of grasps and associated domains of quality of upper extremity skills test (QUEST and grade 2 in manual ability classification system (MACS, assessment done by baseline hand held dynamometer for hand palmar & pinch grasp strength (in pounds at start (0 week, reassessed at 4 & 8 weeks. The treatment protocol for two groups include: 2 months total time, 3 sessions\\ week, 1.5 hour\\session. Children in study group (A received selected occupational therapy program with modified mirror apparatus while children in control group (B Children received the same occupational therapy program as in study group but without modified mirror apparatus. Results: there is significant improvement in both groups when comparing the pre and post I & II treatment mean values. However comparing the post treatment results of both groups were statistically non-significant. Conclusion: This study confirmed that combining mirror therapy and HABIT is effective in improving hand function.

  5. Association of the AMPA receptor-related postsynaptic density proteins GRIP and ABP with subsets of glutamate-sensitive neurons in the rat retina.

    Science.gov (United States)

    Gábriel, Robert; de Souza, Sunita; Ziff, Edward B; Witkovsky, Paul

    2002-07-22

    We used specific antibodies against two postsynaptic density proteins, GRIP (glutamate receptor interacting protein) and ABP (AMPA receptor-binding protein), to study their distribution in the rat retina. In the central nervous system, it has been shown that both proteins bind strongly to the AMPA glutamate receptor (GluR) 2/3 subunits, but not other GluRs, through a set of three PDZ domains. Western blots detected a single GRIP protein that was virtually identical in retina and brain, whereas retinal ABP corresponded to only one of three ABP peptides found in brain. The retinal distributions of GluR2/3, GRIP, and ABP immunoreactivity (IR) were similar but not identical. GluR2/3 immunoreactivity (IR) was abundant in both plexiform layers and in large perikarya. ABP IR was concentrated in large perikarya but was sparse in the plexiform layers, whereas GRIP IR was relatively more abundant in the plexiform layers than in perikarya. Immunolabel for these three antibodies consisted of puncta ABP IR was examined by double labeling subclasses of retinal neuron with characteristic marker proteins, e.g., calbindin. GRIP, ABP, and GluR2/3 IR were detected in horizontal cells, dopaminergic and glycinergic AII amacrine cells and large ganglion cells. Immunolabel was absent in rod bipolar and weak or absent in cholinergic amacrine cells. By using the tyramide method of signal amplification, a colocalization of GluR2/3 was found with either GRIP or ABP in horizontal cell terminals, and perikarya of amacrine and ganglion cells. Our results show that ABP and GRIP colocalize with GluR2/3 in particular subsets of retinal neuron, as was previously established for certain neurons in the brain.

  6. Deficient grip force control in schizophrenia: behavioral and modeling evidence for altered motor inhibition and motor noise.

    Science.gov (United States)

    Teremetz, Maxime; Amado, Isabelle; Bendjemaa, Narjes; Krebs, Marie-Odile; Lindberg, Pavel G; Maier, Marc A

    2014-01-01

    Whether upper limb sensorimotor control is affected in schizophrenia and how underlying pathological mechanisms may potentially intervene in these deficits is still being debated. We tested voluntary force control in schizophrenia patients and used a computational model in order to elucidate potential cerebral mechanisms underlying sensorimotor deficits in schizophrenia. A visuomotor grip force-tracking task was performed by 17 medicated and 6 non-medicated patients with schizophrenia (DSM-IV) and by 15 healthy controls. Target forces in the ramp-hold-and-release paradigm were set to 5 N and to 10% maximal voluntary grip force. Force trajectory was analyzed by performance measures and Principal Component Analysis (PCA). A computational model incorporating neural control signals was used to replicate the empirically observed motor behavior and to explore underlying neural mechanisms. Grip task performance was significantly lower in medicated and non-medicated schizophrenia patients compared to controls. Three behavioral variables were significantly higher in both patient groups: tracking error (by 50%), coefficient of variation of force (by 57%) and duration of force release (up by 37%). Behavioral performance did not differ between patient groups. Computational simulation successfully replicated these findings and predicted that decreased motor inhibition, together with an increased signal-dependent motor noise, are sufficient to explain the observed motor deficits in patients. PCA also suggested altered motor inhibition as a key factor differentiating patients from control subjects: the principal component representing inhibition correlated with clinical severity. These findings show that schizophrenia affects voluntary sensorimotor control of the hand independent of medication, and suggest that reduced motor inhibition and increased signal-dependent motor noise likely reflect key pathological mechanisms of the sensorimotor deficit.

  7. Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction.

    Directory of Open Access Journals (Sweden)

    Xiaoyan Ge

    2014-06-01

    Full Text Available Maternal homozygosity for three independent mutant hecate alleles results in embryos with reduced expression of dorsal organizer genes and defects in the formation of dorsoanterior structures. A positional cloning approach identified all hecate mutations as stop codons affecting the same gene, revealing that hecate encodes the Glutamate receptor interacting protein 2a (Grip2a, a protein containing multiple PDZ domains known to interact with membrane-associated factors including components of the Wnt signaling pathway. We find that grip2a mRNA is localized to the vegetal pole of the oocyte and early embryo, and that during egg activation this mRNA shifts to an off-center vegetal position corresponding to the previously proposed teleost cortical rotation. hecate mutants show defects in the alignment and bundling of microtubules at the vegetal cortex, which result in defects in the asymmetric movement of wnt8a mRNA as well as anchoring of the kinesin-associated cargo adaptor Syntabulin. We also find that, although short-range shifts in vegetal signals are affected in hecate mutant embryos, these mutants exhibit normal long-range, animally directed translocation of cortically injected dorsal beads that occurs in lateral regions of the yolk cortex. Furthermore, we show that such animally-directed movement along the lateral cortex is not restricted to a single arc corresponding to the prospective dorsal region, but occur in multiple meridional arcs even in opposite regions of the embryo. Together, our results reveal a role for Grip2a function in the reorganization and bundling of microtubules at the vegetal cortex to mediate a symmetry-breaking short-range shift corresponding to the teleost cortical rotation. The slight asymmetry achieved by this directed process is subsequently amplified by a general cortical animally-directed transport mechanism that is neither dependent on hecate function nor restricted to the prospective dorsal axis.

  8. EyeGrip: Detecting Targets in a Series of Uni-directional Moving Objects Using Optokinetic Nystagmus Eye Movements

    DEFF Research Database (Denmark)

    Jalaliniya, Shahram; Mardanbeigi, Diako

    2016-01-01

    computers. In this paper, we demonstrate the rich capabilities of EyeGrip with two example applications: 1) a mind reading game, and 2) a picture selection system. Our study shows that by selecting an appropriate speed and maximum number of visible images in the screen the proposed method can be used...... the user looks at a sequence of images moving horizontally on the display while the user's eye movements are tracked by an eye tracker. We conducted an experiment that shows the performance of the proposed approach. We also investigated the influence of the speed and maximum number of visible images...

  9. Modeling the Maturation of Grip Selection Planning and Action Representation: Insights from Typical and Atypical Motor Development.

    OpenAIRE

    Ian eFuelscher; Jacqueline eWilliams; Kate eWilmut; Enticott, Peter G.; Christian eHyde

    2016-01-01

    We investigated the purported association between developmental changes in grip selection planning and improvements in an individual’s capacity to represent action at an internal level (i.e., motor imagery). Participants were groups of healthy children aged 6-7 years and 8-12 years respectively, while a group of adolescents (13-17 years) and adults (18-34 years) allowed for consideration of childhood development in the broader context of motor maturation. A group of children aged 8-12 years w...

  10. Modeling the Maturation of Grip Selection Planning and Action Representation: Insights from Typical and Atypical Motor Development

    OpenAIRE

    Fuelscher, Ian; Williams, Jacqueline; Wilmut, Kate; Enticott, Peter G.; Hyde, Christian

    2016-01-01

    We investigated the purported association between developmental changes in grip selection planning and improvements in an individual’s capacity to represent action at an internal level [i.e., motor imagery (MI)]. Participants were groups of healthy children aged 6–7 years and 8–12 years respectively, while a group of adolescents (13–17 years) and adults (18–34 years) allowed for consideration of childhood development in the broader context of motor maturation. A group of children aged 8–12 ye...

  11. Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation.

    Directory of Open Access Journals (Sweden)

    Samir M Abdelmagid

    Full Text Available BACKGROUND: This study elucidates exposure-response relationships between performance of repetitive tasks, grip strength declines, and fibrogenic-related protein changes in muscles, and their link to inflammation. Specifically, we examined forearm flexor digitorum muscles for changes in connective tissue growth factor (CTGF; a matrix protein associated with fibrosis, collagen type I (Col1; a matrix component, and transforming growth factor beta 1 (TGFB1; an upstream modulator of CTGF and collagen, in rats performing one of two repetitive tasks, with or without anti-inflammatory drugs. METHODOLOGY/RESULTS: To examine the roles of force versus repetition, rats performed either a high repetition negligible force food retrieval task (HRNF, or a high repetition high force handle-pulling task (HRHF, for up to 9 weeks, with results compared to trained only (TR-NF or TR-HF and normal control rats. Grip strength declined with both tasks, with the greatest declines in 9-week HRHF rats. Quantitative PCR (qPCR analyses of HRNF muscles showed increased expression of Col1 in weeks 3-9, and CTGF in weeks 6 and 9. Immunohistochemistry confirmed PCR results, and also showed greater increases of CTGF and collagen matrix in 9-week HRHF rats than 9-week HRNF rats. ELISA, and immunohistochemistry revealed greater increases of TGFB1 in TR-HF and 6-week HRHF, compared to 6-week HRNF rats. To examine the role of inflammation, results from 6-week HRHF rats were compared to rats receiving ibuprofen or anti-TNF-α treatment in HRHF weeks 4-6. Both treatments attenuated HRHF-induced increases in CTGF and fibrosis by 6 weeks of task performance. Ibuprofen attenuated TGFB1 increases and grip strength declines, matching our prior results with anti-TNFα. CONCLUSIONS/SIGNIFICANCE: Performance of highly repetitive tasks was associated with force-dependent declines in grip strength and increased fibrogenic-related proteins in flexor digitorum muscles. These changes were

  12. A COMPARATIVE STUDY TO FIND OUT IMMEDIATE EFFECTIVENESS OF MOVEMENT WITH MOBILIZATION VERSUS ELBOW ORTHOSIS ON PAIN AND GRIP STRENGTH IN LATERAL EPICONDYLITIS IN HOUSEWIVES

    Directory of Open Access Journals (Sweden)

    Trishna Kakati

    2015-12-01

    Full Text Available Background: There are various studies using Mulligan’s MWM with or without combining with electrotherapy modalities and proved the efficacy of the technique in immediately decreasing pain and improving grip strength in patients with lateral epicondylitis. Orthotic as a treatment is also proved to be beneficial in decreasing pain and improving grip strength. There is evidence that housewives are prone to develop lateral epicondylitis due to their routine household work. But there is lack of evidence which compare initial effects of MWM and orthosis in housewives bringing up better outcome measures. The purpose of this study is to compare the initial effectiveness of Mulligan’s MWM and elbow orthosis on pain and grip strength in housewives with lateral epicondylitis. The aim of the study is to evaluate the effectiveness of Mulligan’s MWM technique versus counterforce elbow orthosis in immediately reducing pain and improving grip strength in lateral epicondylitis in housewives. Methodos: All subjects underwent a pre-treatment examination to assess pain and pain free hand grip strength with the help of outcome measures. Subjects were randomly assigned into two groups, A and B respectively; having 25 subjects in each group. Group A was treated with one session of Mulligan’s MWM technique. Group B was treated with Counterforce elbow strap orthosis. Data was assessed pre-treatment and immediately after treatment. Visual Analogue Scale (VAS and hand grip on Hand Grip Dynamometer (HGD were used as outcome measures. Results: Independent t-test was performed to see the effectiveness between Mulligan’s MWM and elbow orthosis. For VAS, t = - 2.243 which is significant at 5% level of significance. It has been inferred that VAS decreases more when Mulligan’s MWM was applied. For HGD, t = 0.878 which is not significant implying that increase in HGD do not differ remarkably for the two treatments. Conclusion: It has been recorded from the study that

  13. EMG discharge patterns during human grip movement are task-dependent and not modulated by muscle contraction modes: a transcranial magnetic stimulation (TMS) study.

    Science.gov (United States)

    Anson, J G; Hasegawa, Y; Kasai, T; Latash, M L; Yahagi, S

    2002-05-03

    Our previous study revealed that, during tonic muscle contraction, remarkable functional differences among intrinsic and extrinsic muscles were observed during two different grip movements, i.e., precision and power grips. To verify whether this evidence is true even under the phasic muscle contraction, magnetic stimulation was delivered over the left scalp while a normal human subject performed phasic precision or power grip responses of the right-hand fingers in a simple reaction time (SRT) paradigm. Magnetic stimulation delivered during the latent period revealed different cortico-motoneuronal excitations between the two grip responses. In particular, the contributions of extensor carpi radialis (ECR) muscle were definitely different between the two grip responses, although motor-evoked potentials (MEPs) of first dorsal interosseous (FDI) prior to, and after EMG onset of movement initiation, were not different. These results were similar to previous results obtained during tonic muscle contraction. Thus, we have concluded that the task-dependent EMG discharge pattern in finger manipulation could not be modulated by muscle contraction modes.

  14. The bilateral movement condition facilitates maximal but not submaximal paretic-limb grip force in people with post-stroke hemiparesis

    Science.gov (United States)

    DeJong, Stacey L.; Lang, Catherine E.

    2012-01-01

    Objectives Although healthy individuals have less force production capacity during bilateral muscle contractions compared to unilateral efforts, emerging evidence suggests that certain aspects of paretic upper limb task performance after stroke may be enhanced by moving bilaterally instead of unilaterally. We investigated whether the bilateral movement condition affects grip force differently on the paretic side of people with post-stroke hemiparesis, compared to their non-paretic side and both sides of healthy young adults. Methods Within a single session, we compared: 1) maximal grip force during unilateral vs. bilateral contractions on each side, and 2) force contributed by each side during a 30% submaximal bilateral contraction. Results Healthy controls produced less grip force in the bilateral condition, regardless of side (- 2.4% difference), and similar findings were observed on the non-paretic side of people with hemiparesis (- 4.5% difference). On the paretic side, however, maximal grip force was increased by the bilateral condition in most participants (+11.3% difference, on average). During submaximal bilateral contractions in each group, the two sides each contributed the same percentage of unilateral maximal force. Conclusions The bilateral condition facilitates paretic limb grip force at maximal, but not submaximal levels. Significance In some people with post-stroke hemiparesis, the paretic limb may benefit from bilateral training with high force requirements. PMID:22248812

  15. [Gait speed, grip strength and self-rated health among the elderly: data from the FIBRA Campinas network, São Paulo, Brazil].

    Science.gov (United States)

    Bez, Joelita Pessoa de Oliveira; Neri, Anita Liberalesso

    2014-08-01

    The article seeks to investigate patterns of performance and relationships between grip strength, gait speed and self-rated health, and investigate the relationships between them, considering the variables of gender, age and family income. This was conducted in a probabilistic sample of community-dwelling elderly aged 65 and over, members of a population study on frailty. A total of 689 elderly people without cognitive deficit suggestive of dementia underwent tests of gait speed and grip strength. Comparisons between groups were based on low, medium and high speed and strength. Self-related health was assessed using a 5-point scale. The males and the younger elderly individuals scored significantly higher on grip strength and gait speed than the female and oldest did; the richest scored higher than the poorest on grip strength and gait speed; females and men aged over 80 had weaker grip strength and lower gait speed; slow gait speed and low income arose as risk factors for a worse health evaluation. Lower muscular strength affects the self-rated assessment of health because it results in a reduction in functional capacity, especially in the presence of poverty and a lack of compensatory factors.

  16. Functional magnetic resonance imaging reveals the neural substrates of arm transport and grip formation in reach-to-grasp actions in humans.

    Science.gov (United States)

    Cavina-Pratesi, Cristiana; Monaco, Simona; Fattori, Patrizia; Galletti, Claudio; McAdam, Teresa D; Quinlan, Derek J; Goodale, Melvyn A; Culham, Jody C

    2010-08-01

    Picking up a cup requires transporting the arm to the cup (transport component) and preshaping the hand appropriately to grasp the handle (grip component). Here, we used functional magnetic resonance imaging to examine the human neural substrates of the transport component and its relationship with the grip component. Participants were shown three-dimensional objects placed either at a near location, adjacent to the hand, or at a far location, within reach but not adjacent to the hand. Participants performed three tasks at each location as follows: (1) touching the object with the knuckles of the right hand; (2) grasping the object with the right hand; or (3) passively viewing the object. The transport component was manipulated by positioning the object in the far versus the near location. The grip component was manipulated by asking participants to grasp the object versus touching it. For the first time, we have identified the neural substrates of the transport component, which include the superior parieto-occipital cortex and the rostral superior parietal lobule. Consistent with past studies, we found specialization for the grip component in bilateral anterior intraparietal sulcus and left ventral premotor cortex; now, however, we also find activity for the grasp even when no transport is involved. In addition to finding areas specialized for the transport and grip components in parietal cortex, we found an integration of the two components in dorsal premotor cortex and supplementary motor areas, two regions that may be important for the coordination of reach and grasp.

  17. Representing tools as hand movements: early and somatotopic visuomotor transformations.

    Science.gov (United States)

    Bartoli, Eleonora; Maffongelli, Laura; Jacono, Marco; D'Ausilio, Alessandro

    2014-08-01

    The term affordance defines a property of objects, which relates to the possible interactions that an agent can carry out on that object. In monkeys, canonical neurons encode both the visual and the motor properties of objects with high specificity. However, it is not clear if in humans exists a similarly fine-grained description of these visuomotor transformations. In particular, it has not yet been proven that the processing of visual features related to specific affordances induces both specific and early visuomotor transformations, given that complete specificity has been reported to emerge quite late (300-450ms). In this study, we applied an adaptation-stimulation paradigm to investigate early cortico-spinal facilitation and hand movements׳ synergies evoked by the observation of tools. We adapted, through passive observation of finger movements, neuronal populations coding either for precision or power grip actions. We then presented the picture of one tool affording one of the two grasps types and applied single-pulse Transcranial Magnetic Stimulation (TMS) to the hand primary motor cortex, 150ms after image onset. Cortico-spinal excitability of the Abductor Digiti Minimi and Abductor Pollicis Brevis showed a detailed pattern of modulations, matching tools׳ affordances. Similarly, TMS-induced hand movements showed a pattern of grip-specific whole hand synergies. These results offer a direct proof of the emergence of an early visuomotor transformation when tools are observed, that maintains the same amount of synergistic motor details as the actions we can perform on them.

  18. Ergonomics applications of a mechanical model of the human operator in power hand tool operation.

    Science.gov (United States)

    Lin, Jia-Hua; Radwin, Robert; Nembhard, David

    2005-02-01

    Applications of a new model for predicting power threaded-fastener-driving tool operator response and capacity to react against impulsive torque reaction forces are explored for use in tool selection and ergonomic workplace design. The model is based on a mechanical analog of the human operator, with parameters dependent on work location (horizontal and vertical distances); work orientation (horizontal and vertical); and tool shape (in-line, pistol grip, and right angle); and is stratified by gender. This model enables prediction of group means and variances of handle displacement and force for a given tool configuration. Response percentiles can be ascertained for specific tool operations. For example, a sample pistol grip nutrunner used on a horizontal surface at 30 cm in front of the ankles and 140 cm above the floor results in a predicted mean handle reaction displacement of 39.0 (SD=28.1) mm for males. Consequently 63%of the male users exceed a 30 mm handle displacement limit. When a right angle tool of similar torque output is used instead, the model predicted that only 4.6%of the male tool users exceed a 30 mm handle displacement. A method is described for interpolating individual subject model parameters at any given work location using linear combinations in relation to the range of modeled factors. Additional examples pertinent to ergonomic workstation design and tool selection are provided to demonstrate how the model can be used to aid tool selection and workstation design.

  19. Analysis of the effects of hospitalization on fine hand functions compared to gross grip in patients with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Zeynep Tuna

    2015-09-01

    Full Text Available Objective: Hospitalization process causes a variety of physical problems. The decrease of hand use in daily life during hospitalization brings hand dysfunction to mind in inpatients. The aim of this study is to compare the hand functions of hospitalized patients with Rheumatoid Arthritis (RA to outpatients in detail. Methods: Grip and pinch strengths of both hospitalized patients in rheumatology service and outpatients on the routine control day were measured. In addition, 9-Hole Peg Test was performed and the disability level was determined by the Turkish version of Michigan Hand Outcomes Questionnaire (MHOQ. Results: While grip strength and MHOQ scores were similar (p>0.05 in both groups, all three pinch strengths (lateral, bipod, tripod and 9HPT scores were lower (p<0.05 in hospitalized patients. Conclusion: Consequently, besides disease activity, hospitalization process also impairs fine hand functions in rheumatological patients. Evaluation of fine hand functions and appropriate rehabilitative interventions may prevent further disability in hospitalized patients. J Clin Exp Invest 2015; 6 (3: 228-232

  20. Evaluation of finger A3 pulley rupture in the crimp grip position - a magnetic resonance imaging cadaver study

    Energy Technology Data Exchange (ETDEWEB)

    Bayer, Thomas; Uder, Michael; Janka, Rolf [University of Erlangen-Nuremberg, Department of Radiology, Erlangen (Germany); Adler, Werner [University of Erlangen-Nuremberg, Department of Biometry and Epidemiology, Erlangen (Germany); Schweizer, Andreas [Balgrist, University of Zurich, Department of Orthopaedics, Zurich (Switzerland); Schoeffl, Isabelle [Klinikum Bamberg, Department of Pediatrics, Bamberg (Germany)

    2015-09-15

    The correct diagnosis of an A3 pulley rupture is challenging for musculoskeletal radiologists. An A3 pulley rupture should in theory influence the shape of the proximal interphalangeal joint volar plate (VP) and the amount of bowstringing at level of the VP during finger flexion. The purpose of this study was to perform MRI with metric analysis of the VP configuration and VP bowstringing in cadaver fingers in the crimp grip position and to determine cut points for A3 pulley rupture. MRI in the crimp grip position was performed in 21 cadaver fingers with artificially created flexor tendon pulley tears (fingers with A3 pulley rupture n = 16, fingers without A3 pulley rupture n = 5). The distances of the translation of the VP relative to the middle phalanx base, the distances between the flexor tendons and the VP body, and the distances between the flexor tendon and bone (TB) were measured. Statistical analysis showed significantly lower VP translation distances and significantly higher VP tendon distances if the A3 pulley was ruptured. A2 TB and A4 TB distances did not differ significantly in specimens with and without A3 pulley rupture. The optimal cut points for A3 pulley rupture were a VP translation distance <2.8 mm and a VP tendon distance >1.4 mm. Reduction of the VP translation distance and augmentation of the VP tendon distance are suitable indirect signs of A3 pulley rupture. (orig.)

  1. Laterality and grip strength influence hand bone micro-architecture in modern humans, an HRpQCT study.

    Science.gov (United States)

    Reina, Nicolas; Cavaignac, Etienne; Trousdale, William H; Laffosse, Jean-Michel; Braga, José

    2017-06-01

    It is widely hypothesized that mechanical loading, specifically repetitive low-intensity tasks, influences the inner structure of cancellous bone. As such, there is likely a relationship between handedness and bone morphology. The aim of this study is to determine patterns in trabecular bone between dominant and non-dominant hands in modern humans. Seventeen healthy patients between 22 and 32 years old were included in the study. Radial carpal bones (lunate, capitate, scaphoid, trapezium, trapezoid, 1st, 2nd and 3rd metacarpals) were analyzed with high-resolution micro-computed tomography. Additionally, crush and pinch grip were recorded. Factorial analysis indicated that bone volume ratio, trabeculae number (Tb.N), bone surface to volume ratio (BS.BV), body weight, stature and crush grip were all positively correlated with principal components 1 and 2 explaining 78.7% of the variance. Volumetric and trabecular endostructural parameters (BV/TV, BS/BV or Tb.Th, Tb.N) explain the observed inter-individual variability better than anthropometric or clinical parameters. Factors analysis regressions showed correlations between these parameters and the dominant side for crush strength for the lunate (r(2) = 0.640, P modern human wrist. © 2017 Anatomical Society.

  2. New results on the relation between tyre-road longitudinal stiffness and maximum available grip for motor car

    Science.gov (United States)

    Andrieux, A.; Vandanjon, P. O.; Lengelle, R.; Chabanon, C.

    2010-12-01

    Tyre-road estimation methods have been the objective of many research programmes throughout the world. Most of these methods aim at estimating the friction components such as tyre longitudinal slip rate κ and friction coefficient μ in the contact patch area. In order to estimate the maximum available friction coefficient μmax, these methods generally use a probabilistic relationship between the grip obtained for low tyre excitations (such as constant speed driving) and the grip obtained for high tyre excitations (such as emergency braking manoeuvre). Confirmation or invalidation of this relationship from experimental results is the purpose of this paper. Experiments have been carried out on a reference track including several test boards corresponding to a wide textural spectrum. The main advantage of these experiments lies in the use of a vehicle allowing us to accurately build point-by-point relationship between κ and μ. This relationship has been determined for different tyres and pavement textures. Finally, the curves obtained are analysed to check the validity of the relationship between the current friction coefficient used by the car during normal driving conditions and μmax.

  3. Sex Differences in the Level and Rate of Change of Physical Function and Grip Strength in the Danish 1905-Cohort Study

    DEFF Research Database (Denmark)

    Oksuzyan, Anna; Maier, Heiner; McGue, Matt;

    2010-01-01

    OBJECTIVE: The study was conducted to examine sex differences in the initial level and rate of change in physical function and grip strength. METHOD: The baseline survey included 2,262 Danes born in 1905 and alive in 1998 and followed-up in 2000, 2003, and 2005. Hence, the authors fully used...... with intercepts and slopes. DISCUSSION: The Danish data suggested that the longest-living individuals have higher initial levels of strength score and grip strength and smaller rate of change. The data further suggested that the initial level of strength score and grip strength was more predictive of mortality...... than the rate of change was, and the predictive effects were similar in men and women....

  4. The effects of joint torque, pace and work:rest ratio on powered hand tool operations.

    Science.gov (United States)

    Lin, Jia-Hua; McGorry, Raymond W; Maikala, Rammohan V

    2012-01-01

    Repetitive use of hand-held power tools is associated with work-related upper extremity musculoskeletal disorders. Using a pneumatic nutrunner, 21 men completed twelve 360 repetitive fastener-driving sessions on three joints (hard, soft and control) at slow and fast pace, and two different work:rest patterns. Handgrip force and perceived exertions were collected throughout each session. For the control joint, the mean grip force exerted was 39.6% of maximum voluntary exertion (MVE) whereas during hard and soft joint sessions it was 48.9% MVE and 56.9% MVE, respectively. Throughout each session, the grip force decreased, more while operating soft and hard joints as compared with the control joint (regression slope: -0.022 and -0.023, compared with -0.007 N/drive, respectively), suggesting considerable upper extremity muscular effort by participants during torque buildup. Fast work pace resulted in higher average grip forces by participants but a greater decrease in the force as the session progressed. Providing rest breaks reduced perceived exertions. The findings gain additional knowledge for assembly task design to possibly reduce the hand/arm injury risks for the operator. Practitioner Summary: Powered hand tools are widely used in assembly and manufacturing industries. However, the nature of their repetitive use on human operator biomechanical and perceptual responses is not fully understood. This study examined work-related risk factors such as joint torque, pace and work:rest ratios on powered hand tool performance.

  5. Simulation tools

    CERN Document Server

    Jenni, F

    2006-01-01

    In the last two decades, simulation tools made a significant contribution to the great progress in development of power electronics. Time to market was shortened and development costs were reduced drastically. Falling costs, as well as improved speed and precision, opened new fields of application. Today, continuous and switched circuits can be mixed. A comfortable number of powerful simulation tools is available. The users have to choose the best suitable for their application. Here a simple rule applies: The best available simulation tool is the tool the user is already used to (provided, it can solve the task). Abilities, speed, user friendliness and other features are continuously being improved—even though they are already powerful and comfortable. This paper aims at giving the reader an insight into the simulation of power electronics. Starting with a short description of the fundamentals of a simulation tool as well as properties of tools, several tools are presented. Starting with simplified models ...

  6. Grip Strength Decline and Its Determinants in the Very Old: Longitudinal Findings from the Newcastle 85+ Study

    Science.gov (United States)

    Davies, Karen; Jagger, Carol; Kirkwood, Thomas B. L.; Syddall, Holly E.; Sayer, Avan A.

    2016-01-01

    Background Weak grip strength (GS) is a key component of sarcopenia and frailty and a powerful predictor of mortality, morbidity and disability. Despite increasing interest in understanding GS across the lifespan, little is known about GS decline in the very old (aged ≥85). We examined trajectories of GS in very old adults and identified the determinants. Methods GS (kg) was measured four times over 5 years in 319 men and 526 women participating in the Newcastle 85+ Study. A weak GS sub-cohort was identified as having strength of ≤27 kg (men), and ≤16 kg (women) at baseline and follow-up. Mixed models were used to establish trajectories of GS and associated factors in all participants, men and women, and in those with weak GS. Results Men’s mean grip strength was 24.42 (SD = 6.77) kg, and women’s 13.23 (4.42) kg (p<0.001) at baseline, with mean absolute change of -5.27 (4.90) kg and -3.14 (3.41), respectively (p<0.001) by 5-year follow-up. In the time-only mixed model, men experienced linear annual decline in GS of -1.13 (0.8) kg (β (SE), p<0.001), whilst women’s decline although slower, accelerated by -0.06 (0.02) kg (p = 0.01) over time. In the saturated model, higher baseline physical activity, height, fat-free mass, better self-rated health, and not having arthritis in hand(s) were associated with stronger GS initially in both sexes. Annual GS decline in men and participants with weak GS who were highly physically active was slower by 0.95 and 0.52 kg, respectively compared with inactive counterparts. Conclusion Grip strength decline in the very old followed linear (men) and curvilinear (women) trends. High levels of physical activity were protective of GS loss in men (but not in women) and in those with weak GS. Thus maintaining muscle strength in later life is important to reduce the morbidity and mortality in the very old. PMID:27637107

  7. Cross-talk in mechanomyographic signals from the forearm muscles during sub-maximal to maximal isometric grip force.

    Directory of Open Access Journals (Sweden)

    Md Anamul Islam

    Full Text Available PURPOSE: This study aimed: i to examine the relationship between the magnitude of cross-talk in mechanomyographic (MMG signals generated by the extensor digitorum (ED, extensor carpi ulnaris (ECU, and flexor carpi ulnaris (FCU muscles with the sub-maximal to maximal isometric grip force, and with the anthropometric parameters of the forearm, and ii to quantify the distribution of the cross-talk in the MMG signal to determine if it appears due to the signal component of intramuscular pressure waves produced by the muscle fibers geometrical changes or due to the limb tremor. METHODS: Twenty, right-handed healthy men (mean ± SD: age  = 26.7±3.83 y; height  = 174.47±6.3 cm; mass  = 72.79±14.36 kg performed isometric muscle actions in 20% increment from 20% to 100% of the maximum voluntary isometric contraction (MVIC. During each muscle action, MMG signals generated by each muscle were detected using three separate accelerometers. The peak cross-correlations were used to quantify the cross-talk between two muscles. RESULTS: The magnitude of cross-talk in the MMG signals among the muscle groups ranged from, R2(x, y = 2.45-62.28%. Linear regression analysis showed that the magnitude of cross-talk increased linearly (r2 = 0.857-0.90 with the levels of grip force for all the muscle groups. The amount of cross-talk showed weak positive and negative correlations (r2 = 0.016-0.216 with the circumference and length of the forearm respectively, between the muscles at 100% MVIC. The cross-talk values significantly differed among the MMG signals due to: limb tremor (MMGTF, slow firing motor unit fibers (MMGSF and fast firing motor unit fibers (MMGFF between the muscles at 100% MVIC (p<0.05, η2 = 0.47-0.80. SIGNIFICANCE: The results of this study may be used to improve our understanding of the mechanics of the forearm muscles during different levels of the grip force.

  8. From Single Motor Unit Activity to Multiple Grip Forces: Mini‐review of Multi‐digit Grasping1

    Science.gov (United States)

    Winges, Sara A.; Santello, Marco

    2007-01-01

    SYNOPSIS This paper is a mini review of kinetic and kinematic evidence on the control of the hand with emphasis on grasping. It is not meant to be an exhaustive review, rather it summarizes current research examining the mechanisms through which specific patterns of coordination are elicited and observed during reach to grasp movements and static grasping. These coordination patterns include the spatial and temporal covariation of the rotation at multiple joints during reach to grasp movements. A basic coordination between grip forces produced by multiple digits also occurs during whole hand grasping such that normal forces tend to be produced in a synchronous fashion across pairs of digits. Finally, we address current research that suggests that motor unit synchrony across hand muscles and muscle compartments might be one of the neural mechanisms underlying the control of grasping. PMID:18414593

  9. Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation

    Science.gov (United States)

    Yu, Qiang; Ottmann, Michele; Pechoux, Christine; Le Grice, Stuart; Darlix, Jean-Luc

    1998-01-01

    This report describes the effects of mutating highly conserved residues in the primer grip domain of human immunodeficiency virus type 1 reverse transcriptase (RT) on virus formation and infectivity. Among a series of RT mutant viruses, three (M230A, L234D, and W239A) were found to be noninfectious or very poorly infectious. Our data indicate that these mutations in RT caused severe defects in proviral DNA synthesis. Interestingly, assembly and maturation of mutant virus M230A were similar to those of the wild type, while mutants L234D and W239A showed impaired maturation. The immature morphology of RT mutants L234D and W239A is due at least in part to premature cleavage of the gag-pol precursor, prior to virion budding, indicating that intracellular stability of Pr160gag-pol is of key importance during virus assembly. PMID:9696874

  10. Coming to Grips with Farmers' variety Selection- the Case of New Improved Rice Varieties under Irrigation in South East Tanzania

    Directory of Open Access Journals (Sweden)

    Kafiriti, EM.

    2003-01-01

    Full Text Available In collaboration with farmers, rice varieties were evaluated under small-scale irrigation in two villages of south east Tanzania for two consecutive cropping seasons (1999/2000 –2000/2001. The objectives were to give farmers access to new improved rice varieties; to identify the selection criteria farmers consider important in irrigated rice production; and to come to grips with their arguments. Farmers were provided with eleven improved varieties, which they compared with their own ones. Farmers' preferred varieties with short to medium maturity period, which produce many tillers and mature uniformly; and with long translucent aromatic grains for their own use and marketing. This study identified qualitative and quantitative evaluation criteria which farmers are using for selecting rice varieties. The implication for further research on rice in south east Tanzania is that the breeding programme should incorporate these attributes to address farmers' preferences, rather than to go for absolute maximum yield levels.

  11. Grip force and heart rate responses to manual carrying tasks: effects of material, weight, and base area of the container.

    Science.gov (United States)

    Lee, Tzu-Hsien; Tseng, Chia-Yun

    2014-01-01

    This study recruited 16 industrial workers to examine the effects of material, weight, and base area of container on reduction of grip force (ΔGF) and heart rate for a 100-m manual carrying task. This study examined 2 carrying materials (iron and water), 4 carrying weights (4.4, 8.9, 13.3, 17.8 kg), and 2 base areas of container (24 × 24 cm, 35 × 24 cm). This study showed that carrying water significantly increased ΔGF and heart rate as compared with carrying iron. Also, ΔGF and heart rate significantly increased with carrying weight and base area of container. The effects of base area of container on ΔGF and heart rate were greater in carrying water condition than in carrying iron condition. The maximum dynamic effect of water on ΔGF and heart rate occurred when water occupied ~60%-80% of full volume of the container.

  12. centrosomin's beautiful sister (cbs) encodes a GRIP-domain protein that marks Golgi inheritance and functions in the centrosome cycle in Drosophila.

    Science.gov (United States)

    Eisman, Robert C; Stewart, Natasha; Miller, David; Kaufman, Thomas C

    2006-08-15

    The mechanism of inheritance of the Golgi complex is an important problem in cell biology. In this study, we examine the localization and function of a Golgi protein encoded by centrosomin's beautiful sister (cbs) during cleavage in Drosophila melanogaster. Cbs contains a GRIP domain that is 57% identical to vertebrate Golgin-97. Cbs undergoes a dramatic relocalization during mitosis from the cytoplasm to an association with chromosomes from late prometaphase to early telophase, by a transport mechanism that requires the GRIP domain and Arl1, the product of the Arf72A locus. Additionally, Cbs remains independent of the endoplasmic reticulum throughout cleavage. The use of RNAi, Arf72A mutant analysis and ectopic expression of the GRIP domain, shows that cycling of Cbs during mitosis is required for the centrosome cycle. The effects on the centrosome cycle depend on Cbs concentration and Cbs transport from the cytoplasm to DNA. When Cbs levels are reduced centrosomes fail to mature, and when Cbs transport is impeded by ectopic expression of the GRIP domain, centrosomes undergo hypertrophy. We propose that, Cbs is a trans-Golgi protein that links Golgi inheritance to the cell cycle and the Drosophila Golgi is more vertebrate-like than previously recognized.

  13. Description of Primary Education 1st Grade Students' Forms of Holding a Pencil as well as Their Grip and Compression Strengths

    Science.gov (United States)

    Temur, Turan

    2011-01-01

    This study aimed to examine how first grade students in primary education held and gripped a pencil and their compressive strength using a descriptive research method. The participants of the research comprises first grade students attending a private school in the city center of Ankara (n=79). All of the four different sections in this private…

  14. Associations of work activities requiring pinch or hand grip or exposure to hand-arm vibration with finger and wrist osteoarthritis

    DEFF Research Database (Denmark)

    Hammer, Paula E C; Shiri, Rahman; Kryger, Ann I;

    2014-01-01

    -analyses. RESULTS: Of the 19 studies included, 17 were cross-sectional, 1 was a prospective cohort, and 1 a case-control study. The meta-analyses of studies that controlled their estimates for at least age and gender showed the associations of pinch grip work with proximal interphalangeal joint [OR 1.56, 95...

  15. Microscopic vision modeling method by direct mapping analysis for micro-gripping system with stereo light microscope.

    Science.gov (United States)

    Wang, Yuezong; Zhao, Zhizhong; Wang, Junshuai

    2016-04-01

    We present a novel and high-precision microscopic vision modeling method, which can be used for 3D data reconstruction in micro-gripping system with stereo light microscope. This method consists of four parts: image distortion correction, disparity distortion correction, initial vision model and residual compensation model. First, the method of image distortion correction is proposed. Image data required by image distortion correction comes from stereo images of calibration sample. The geometric features of image distortions can be predicted though the shape deformation of lines constructed by grid points in stereo images. Linear and polynomial fitting methods are applied to correct image distortions. Second, shape deformation features of disparity distribution are discussed. The method of disparity distortion correction is proposed. Polynomial fitting method is applied to correct disparity distortion. Third, a microscopic vision model is derived, which consists of two models, i.e., initial vision model and residual compensation model. We derive initial vision model by the analysis of direct mapping relationship between object and image points. Residual compensation model is derived based on the residual analysis of initial vision model. The results show that with maximum reconstruction distance of 4.1mm in X direction, 2.9mm in Y direction and 2.25mm in Z direction, our model achieves a precision of 0.01mm in X and Y directions and 0.015mm in Z direction. Comparison of our model with traditional pinhole camera model shows that two kinds of models have a similar reconstruction precision of X coordinates. However, traditional pinhole camera model has a lower precision of Y and Z coordinates than our model. The method proposed in this paper is very helpful for the micro-gripping system based on SLM microscopic vision.

  16. Muscle-Pair Specific Distribution and Grip-Type Modulation of Neural Common Input to Extrinsic Digit Flexors

    Science.gov (United States)

    Winges, Sara A.; Johnston, Jamie A.; Santello, Marco

    2007-01-01

    To gain insight into the synergistic control of hand muscles, we have recently quantified the strength of correlated neural activity across motor units from extrinsic digit flexors during a five-digit object-hold task. We found stronger synchrony and coherence across motor units from thumb and index finger flexor muscle compartment than between the thumb flexor and other finger flexor muscle compartments. The present study of two-digit object hold was designed to determine the extent to which such distribution of common input among thumb-finger flexor muscle compartments, revealed by holding an object with five digits, is preserved when varying the functional role of a given digit pair. We recorded normal force exerted by the digits and electrical activity of single motor units from muscle flexor pollicis longus (FPL) and two compartments of the m. flexor digitorum profundus (FDP2 and FDP3; index and middle finger, respectively). Consistent with our previous results from five-digit grasping, synchrony and coherence across motor units from FPL-FDP2 was significantly stronger than in FPL-FDP3 during object hold with two digits [common input strength: 0.49 ± 0.02 and 0.35 ± 0.02 (means ± SE), respectively; peak coherence: 0.0054 and 0.0038, respectively]. This suggests that the distribution of common neural input is muscle-pair specific regardless of grip type. However, the strength of coherence, but not synchrony, was significantly stronger in two- versus five-digit object hold for both muscle combinations, suggesting the periodicity of common input is sensitive to grip type. PMID:16723414

  17. Combining displacement field and grip force information to determine mechanical properties of planar tissue with complicated geometry.

    Science.gov (United States)

    Nagel, Tina M; Hadi, Mohammad F; Claeson, Amy A; Nuckley, David J; Barocas, Victor H

    2014-11-01

    Performing planar biaxial testing and using nominal stress-strain curves for soft-tissue characterization is most suitable when (1) the test produces homogeneous strain fields, (2) fibers are aligned with the coordinate axes, and (3) strains are measured far from boundaries. Some tissue types [such as lamellae of the annulus fibrosus (AF)] may not allow for these conditions to be met due to their natural geometry and constitution. The objective of this work was to develop and test a method utilizing a surface displacement field, grip force-stretch data, and finite-element (FE) modeling to facilitate analysis of such complex samples. We evaluated the method by regressing a simple structural model to simulated and experimental data. Three different tissues with different characteristics were used: Superficial pectoralis major (SPM) (anisotropic, aligned with axes), facet capsular ligament (FCL) (anisotropic, aligned with axes, bone attached), and a lamella from the AF (anisotropic, aligned off-axis, bone attached). We found that the surface displacement field or the grip force-stretch data information alone is insufficient to determine a unique parameter set. Utilizing both data types provided tight confidence regions (CRs) of the regressed parameters and low parameter sensitivity to initial guess. This combined fitting approach provided robust characterization of tissues with varying fiber orientations and boundaries and is applicable to tissues that are poorly suited to standard biaxial testing. The structural model, a set of C++ finite-element routines, and a Matlab routine to do the fitting based on a set of force/displacement data is provided in the on-line supplementary material.

  18. Past surface temperatures at the NorthGRIP drill site from the difference in firn diffusion of water isotopes

    Directory of Open Access Journals (Sweden)

    S. B. Simonsen

    2011-03-01

    Full Text Available A new ice core paleothermometer is introduced based on the temperature dependent diffusion of the stable water isotopes in the firn. A new parameter called differential diffusion length is defined as the difference between the diffusion length of the two stable water isotopes 18O and deuterium. A model treatment of the diffusion process of the firn and the ice is presented along with a method of retrieving the diffusion signal from the ice core record of water isotopes using spectral methods. The model shows how the diffusion process is highly dependent on the inter-annual variations in the surface temperatures resulting in a longer diffusion length than by assuming an isothermal firn. The longer diffusion length can be explained by the strong non-linearly behavior of the saturation pressure over ice in the range of the surface temperature fluctuations.

    The method has been tested on δ18O and δD measurements, spanning the transition from the last glacial to the holocene, from the NorthGRIP ice core. The surface temperature reconstruction based on the differential diffusion resembles other temperature reconstructions for the NorthGRIP ice core. However, the Allerød warming is seen to be significantly warmer than observed in other ice core based temperature reconstructions. The mechanisms behind this behavior are not fully understood.

    The method shows the need of an expansion of high resolution stable water isotopes data sets from ice cores. However, the new ice core paleothermometer presented here will give valuable insight in past climate, through the physical process of isotope diffusion in the firn column of ice sheets.

  19. Tongue Strength is Associated with Grip Strength and Nutritional Status in Older Adult Inpatients of a Rehabilitation Hospital.

    Science.gov (United States)

    Sakai, Kotomi; Nakayama, Enri; Tohara, Haruka; Maeda, Tomomi; Sugimoto, Motonobu; Takehisa, Takahiro; Takehisa, Yozo; Ueda, Koichiro

    2017-04-01

    The aim of this cross-sectional study was to investigate whether tongue strength observed in older adult inpatients of a rehabilitation hospital is associated with muscle function, nutritional status, and dysphagia. A total of 174 older adult inpatients aged 65 years and older in rehabilitation (64 men, 110 women; median age, 84 years; interquartile range, 80-89 years) who were suspected of having reduced tongue strength due to sarcopenia were included in this study. Isometric tongue strength was measured using a device fitted with a disposable oral balloon probe. We evaluated age, muscle function as assessed by the Barthel index and grip strength, nutritional status as measured by the Mini Nutritional Assessment-short form (MNA-SF), body mass index, serum albumin, controlling nutritional status, and calf circumference and arm muscle area to assess muscle mass. In addition, the functional oral intake scale (FOIS) was used as an index of dysphagia. Multivariate linear regression analysis revealed that isometric tongue strength was independently associated with grip strength (coefficient = 0.33, 95 % confidence interval (CI) 0.12-0.54, p = 0.002), MNA-SF (coefficient = 0.74, 95 % CI 0.12-1.35, p = 0.019), and FOIS (coefficient = 0.02, 95 % CI 0.00-0.15, p = 0.047). To maintain and improve tongue strength in association with sarcopenic dysphagia, exercise therapy and nutritional therapy interventions, as well as direct interventions to address tongue strength, may be effective in dysphagia rehabilitation in older adult inpatients.

  20. Past surface temperatures at the NorthGRIP drill site from the difference in firn diffusion of water isotopes

    Directory of Open Access Journals (Sweden)

    S. B. Simonsen

    2011-12-01

    Full Text Available A new ice core paleothermometer is introduced based on the temperature dependent diffusion of the stable water isotopes in the firn. A new parameter called differential diffusion length is defined as the difference between the diffusion length of the two stable water isotopologues 2H1H16O and 1H218O. A model treatment of the diffusion process of the firn and the ice is presented along with a method of retrieving the diffusion signal from the ice core record of water isotopes using spectral methods. The model shows how the diffusion process is highly dependent on the inter-annual variations in the surface temperatures. It results in a diffusion length longer than if the firn was isothermal. The longer diffusion length can be explained by the strong nonlinearly behaviour of the saturation pressure over ice in the range of the surface temperature fluctuations.

    The method has been tested on δ18O and δD measurements, spanning the transition from the last glacial to the holocene, from the NorthGRIP ice core. The surface temperature reconstruction based on the differential diffusion resembles other temperature reconstructions for the NorthGRIP ice core. However, the Allerød warming is seen to be significantly warmer than observed in other ice core based temperature reconstructions. The mechanisms behind this behaviour are not fully understood.

    The method shows the need of an expansion of high resolution stable water isotope datasets from ice cores. However, the new ice core paleothermometer presented here will give valuable insight into past climate, through the physical process of isotope diffusion in the firn column of ice sheets.

  1. Bilateral deficits in fine motor control and pinch grip force are not associated with electrodiagnostic findings in women with carpal tunnel syndrome.

    Science.gov (United States)

    de la Llave-Rincón, Ana Isabel; Fernández-de-Las-Peñas, César; Pérez-de-Heredia-Torres, Marta; Martínez-Perez, Almudena; Valenza, Marie Carmen; Pareja, Juan A

    2011-06-01

    : The aim of this study was to analyze the differences in deficits in fine motor control and pinch grip force between patients with minimal, moderate/mild, or severe carpal tunnel syndrome (CTS) and healthy age- and hand dominance-matched controls. : A case-control study was conducted. The subtests of the Purdue Pegboard Test (one-hand and bilateral pin placements and assemblies) and pinch grip force between the thumb and the remaining four fingers of the hand were bilaterally evaluated in 66 women with minimal (n = 16), moderate (n = 16), or severe (n = 34) CTS and in 20 age- and hand-matched healthy women. The differences among the groups were analyzed using different mixed models of analysis of variance. : A two-way mixed analysis of variance revealed significant differences between groups, not depending on the presence of unilateral or bilateral symptoms (side), for the one-hand pin placement subtest: patients showed bilateral lower scores compared with controls (P < 0.001), without differences among those with minimal, moderate, or severe CTS (P = 0.946). The patients also exhibited lower scores in bilateral pin placement (P < 0.001) and assembly (P < 0.001) subtests, without differences among them. The three-way analysis of variance revealed significant differences among groups (P < 0.001) and fingers (P < 0.001), not depending on the presence of unilateral/bilateral symptoms (P = 0.684), for pinch grip force: patients showed bilateral lower pinch grip force in all fingers compared with healthy controls, without differences among those with minimal, moderate, or severe CTS. : The current study revealed similar bilateral deficits in fine motor control and pinch grip force in patients with minimal, moderate, or severe CTS, supporting that fine motor control deficits are a common feature of CTS not associated with electrodiagnostic findings.

  2. Coordination of precision grip in 2-6 year-old children with autism spectrum disorders compared to children developing typically and children with developmental disabilities

    Directory of Open Access Journals (Sweden)

    Fabian Jude David

    2012-12-01

    Full Text Available Impaired motor coordination is prevalent in children with Autism Spectrum Disorders (ASD and affects adaptive skills. Little is known about the development of motor patterns in young children with ASD between 2 and 6 years of age. The purpose of the current study was threefold: 1 to describe developmental correlates of motor coordination in children with ASD, 2 to identify the extent to which motor coordination deficits are unique to ASD by using a control group of children with other developmental disabilities (DD, and 3 to determine the association between motor coordination variables and functional fine motor skills. Twenty-four children with ASD were compared to 30 children with typical development (TD and 11 children with DD. A precision grip task was used to quantify and analyze motor coordination. The motor coordination variables were two temporal variables (grip to load force onset latency and time to peak grip force and two force variables (grip force at onset of load force and peak grip force. Functional motor skills were assessed using the Fine Motor Age Equivalents of the Vineland Adaptive Behavior Scale and the Mullen Scales of Early Learning. Mixed regression models were used for all analyses. Children with ASD presented with significant motor coordination deficits only on the two temporal variables, and these variables differentiated children with ASD from the children with TD, but not from children with DD. Fine motor functional skills had no statistically significant associations with any of the motor coordination variables. These findings suggest that subtle problems in the timing of motor actions, possibly related to maturational delays in anticipatory feed-forward mechanisms, may underlie some motor deficits reported in children with ASD, but that these issues are not unique to this population. Further research is needed to investigate how children with ASD or DD compensate for motor control deficits to establish functional

  3. A new classification for 'Pistol Grip Deformity'. Correlation between the severity of the deformity and the grade of osteoarthritis of the hip

    Energy Technology Data Exchange (ETDEWEB)

    Ipach, Ingmar; Mittag, F.; Sachsenmaier, S.; Kluba, T. [Tuebingen Univ. (Germany). Dept. of Orthopaedic Surgery; Heinrich, P. [Klinikum rechts der Isar der Technischen Univ. Muenchen (Germany). Inst. fuer Medizinische Statistik und Epidemiologie

    2011-04-15

    Purpose: Two types of femoroacetabular impingement (FAI) are described as reasons for the early development of osteoarthritis of the hip. Cam impingement develops from contact between an abnormal head-neck junction and the acetabular rim. Pincer impingement is characterized by local or general overcoverage of the femoral head by the acetabular rim. Both forms might cause early osteoarthritis of the hip. A decreased head/neck offset has been recognized on AP pelvic views and labeled as 'pistol grip deformity'. The aim of the study was to develop a classification for this deformity with regard to the stage of osteoarthritis of the hip. Materials and Methods: 76 pelvic and axial views were analyzed for alpha angle and head ratio. 22 of them had a normal shape in the head-neck region and no osteoarthritis signs, 27 had a 'pistol grip deformity' and osteoarthritis I and 27 had a 'pistol grip deformity' and osteoarthritis II -IV . The CART method was used to develop a classification. Results: There was a statistically significant correlation between alpha angle and head ratio. A statistically significant difference in alpha angle and head ratio was seen between the three groups. Using the CART method, we developed a three-step classification system for the 'pistol grip deformity' with very high accuracy. This deformity was aggravated by increasing age. Conclusion: Using this model it is possible to differentiate between normal shapes of the head-neck junction and different severities of the pistol grip deformity. (orig.)

  4. A stability tool for use within TELEGRIP

    Energy Technology Data Exchange (ETDEWEB)

    Son, W.H.; Trinkle, J.C. [Texas A and M Univ., College Station, TX (United States)

    1998-12-01

    During the assembly of a product, it is vital that the partially-completed assembly be stable. To guarantee this, one must ensure that contacts among the parts and the fixtures are sufficient to stabilize the assembly. Thus, it would be desirable to have an efficient method for testing an assembly stability, and, if this is not possible, generating a set of additional fixture contact points, known as fixels, that will stabilize it. One can apply this method to the situation of safe handling of special nuclear material (SNM). To have these functionalities should help improve the safety and enhance the performance of special nuclear material (SNM) handling and storage operations, since some methods are needed for gripping objects in a stable manner. Also, one may need a way to find a pit-holding fixture inserted into containers. In this paper, the authors present a stability tool, which they call Stab Tool, which was developed to test the stability of objects grasped by robotic hands, objects placed in fixtures, or sets of objects piled randomly on top of one another. Stab Tool runs on top of a commercial software package, TELEGRIP, which is used for geometry modeling and motion creation. The successful development of the stability depends strongly on TELEGRIP`s ability to compute the distances between pairs of three-dimensional bodies in the simulated environment. The interbody distance computation tool takes advantage of the polyhedral representations of bodies used by TELEGRIP and of linear programming techniques to yield an efficient algorithm.

  5. The variability of the isotopic signal during the last Glacial as seen from the ultra-high resolution NEEM and NorthGRIP ice cores.

    Science.gov (United States)

    Gkinis, Vasileios; Møllesøe Vinther, Bo; Terkelsen Holme, Christian; Capron, Emilie; Popp, Trevor James; Olander Rasmussen, Sune

    2017-04-01

    The continuity and high resolution available in polar ice core records constitutes them an excellent tool for the study of the stadial-interstadial transitions, notably through the study of the water isotopic composition of polar precipitation (δ18O, δD ). The quest for the highest resolution possible has resulted in experimental sampling and analysis techniques that have yielded data sets with a potential to change the current picture on the climatic signals of the last Glacial. Specifically, the ultra-high resolution δ18O signals from the NorthGRIP and NEEM ice cores, present a variability at multi-annual and decadal time scales, whose interpretation gives rise to further puzzling though interesting questions and an obvious paradox. By means of simple firn isotope diffusion and densification calculations, we firstly demonstrate that the variability of observed signals is unlikely to be due to post depositional effects that are known to occur on the surface of the Greenland ice cap and alter the δ18O composition of the precipitated snow. Assuming specific values for the δ18O sensitivity to temperature (commonly referred to as the δ18O slope), we estimate that the temperature signal during the stadials has a variability that extents from interstadial to extremely cold levels with peak-to-peak fluctuations of almost 35 K occurring in a few years. Similarly, during interstadial phases the temperature varies rapidly from stadial to Holocene levels while the signal variability shows a maximum during the LGM, with magnitudes of up to 15‰ that translate to ≈ 50 K when a δ18O slope of 0.3‰K-1 is used. We assess the validity of these results and comment on the stability of the δ18O slope. Driven by a simple logical queue, we conclude that the observed δ18O variability reflects a climatic signal although not necessarily attributed 100% to temperature changes. From this we can assume that there occur climatic mechanisms during the previously thought stable

  6. Sweating responses to isometric hand-grip exercise and forearm muscle metaboreflex in prepubertal children and elderly.

    Science.gov (United States)

    Amano, Tatsuro; Kai, Seiko; Nakajima, Michi; Ichinose-Kuwahara, Tomoko; Gerrett, Nicola; Kondo, Narihiko; Inoue, Yoshimitsu

    2017-02-01

    What is the central question of this study? Non-thermal factors (e.g. muscle metaboreflex) contribute to the sweating response during exercise. Although it is well recognized that the sweating responses caused by core temperature elevation in prepubertal children and the elderly are attenuated compared with young adults, it is unknown whether non-thermal sweating is also attenuated in these populations. What is the main finding and its importance? The non-thermal sweating response during isometric hand-grip exercise and isolated muscle metaboreflex were attenuated in prepubertal children compared with young adults in a non-uniform manner over the body, but only during the muscle metaboreflex in the elderly. This may explain the maturation- and ageing-related decline of sweating during exercise. The purpose of the present study was to investigate sweating responses to isometric hand-grip (IH) exercise and muscle metaboreflex in prepubertal children and the elderly. In hot conditions (ambient temperature, 35°C; relative humidity, 45%), 13 healthy young adults, 10 prepubertal children and 10 elderly subjects (aged 20.4 ± 1.2, 11.4 ± 0.5 and 63.5 ± 3.1 years, respectively) repeated a three hand-grip exercise protocol that consisted of 1 min IH exercise at 15, 30 or 45% of maximal voluntary contraction (MVC) followed by 2 min postexercise forearm occlusion. Local sweat rates (SRs) on the forehead, chest, forearm, thigh and palm were continuously measured (ventilated capsule method). The forehead SR in prepubertal children during IH exercise at 45% MVC was significantly lower than that of young adults (0.26 ± 0.22 and 0.08 ± 0.15 mg cm(-2)  min(-1) for young adults and children, respectively; P elderly at any exercise intensities. The SR on the chest (0.22 ± 0.22 and -0.01 ± 0.05 mg cm(-2)  min(-1) for young adults and children, respectively), forearm (0.14 ± 0.12 and 0.03 ± 0.04 mg cm(-2)  min(-1) ) and thigh (0.13 ± 0.10 and 0

  7. The Effectiveness of Manual Therapy Versus Surgery on Self-reported Function, Cervical Range of Motion, and Pinch Grip Force in Carpal Tunnel Syndrome: A Randomized Clinical Trial.

    Science.gov (United States)

    Fernández-de-Las-Peñas, César; Cleland, Joshua; Palacios-Ceña, María; Fuensalida-Novo, Stella; Pareja, Juan A; Alonso-Blanco, Cristina

    2017-03-01

    Study Design Randomized parallel-group trial. Background Carpal tunnel syndrome (CTS) is a common pain condition that can be managed surgically or conservatively. Objective To compare the effectiveness of manual therapy versus surgery for improving self-reported function, cervical range of motion, and pinch-tip grip force in women with CTS. Methods In this randomized clinical trial, 100 women with CTS were randomly allocated to either a manual therapy (n = 50) or a surgery (n = 50) group. The primary outcome was self-rated hand function, assessed with the Boston Carpal Tunnel Questionnaire. Secondary outcomes included active cervical range of motion, pinch-tip grip force, and the symptom severity subscale of the Boston Carpal Tunnel Questionnaire. Patients were assessed at baseline and 1, 3, 6, and 12 months after the last treatment by an assessor unaware of group assignment. Analysis was by intention to treat, with mixed analyses of covariance adjusted for baseline scores. Results At 12 months, 94 women completed the follow-up. Analyses showed statistically significant differences in favor of manual therapy at 1 month for self-reported function (mean change, -0.8; 95% confidence interval [CI]: -1.1, -0.5) and pinch-tip grip force on the symptomatic side (thumb-index finger: mean change, 2.0; 95% CI: 1.1, 2.9 and thumb-little finger: mean change, 1.0; 95% CI: 0.5, 1.5). Improvements in self-reported function and pinch grip force were similar between the groups at 3, 6, and 12 months. Both groups reported improvements in symptom severity that were not significantly different at all follow-up periods. No significant changes were observed in pinch-tip grip force on the less symptomatic side and in cervical range of motion in either group. Conclusion Manual therapy and surgery had similar effectiveness for improving self-reported function, symptom severity, and pinch-tip grip force on the symptomatic hand in women with CTS. Neither manual therapy nor surgery resulted

  8. Tool steels

    DEFF Research Database (Denmark)

    Højerslev, C.

    2001-01-01

    On designing a tool steel, its composition and heat treatment parameters are chosen to provide a hardened and tempered martensitic matrix in which carbides are evenly distributed. In this condition the matrix has an optimum combination of hardness andtoughness, the primary carbides provide...... resistance against abrasive wear and secondary carbides (if any) increase the resistance against plastic deformation. Tool steels are alloyed with carbide forming elements (Typically: vanadium, tungsten, molybdenumand chromium) furthermore some steel types contains cobalt. Addition of alloying elements...

  9. Relationship between blood lactate and cortical excitability between taekwondo athletes and non-athletes after hand-grip exercise.

    Science.gov (United States)

    Moscatelli, Fiorenzo; Valenzano, Anna; Petito, Annamaria; Triggiani, Antonio Ivano; Ciliberti, Michela Anna Pia; Luongo, Livio; Carotenuto, Marco; Esposito, Maria; Messina, Antonietta; Monda, Vincenzo; Monda, Marcellino; Capranica, Laura; Messina, Giovanni; Cibelli, Giuseppe

    2016-06-01

    In taekwondo competitions, fatigue has a large influence on performance. Recent studies have reported that the excitability in the primary hand motor cortex, investigated with transcranial magnetic stimulation (TMS), is enhanced at the end of a maximal exercise and that this improvement correlates with blood lactate. The aim of the present study was to investigate the relationship between blood lactate and cortical excitability in taekwondo athletes and non-athletes. The excitability of the primary motor cortex was measured before and after fatiguing hand-grip exercise by TMS. Capillary blood lactate was measured at rest (pre-test), at the end (0 min), and at 3 and 10 min after the exercise by using a "Lactate Pro" portable lactate analyzer. Significant differences in cortical excitability between the two groups were found after the exercise (p taekwondo athletes, lactate may delay the onset of fatigue not only by maintaining the excitability of muscle, but also by increasing the excitability of the primary motor cortex more than in non-athletes.

  10. Drip, ship, and grip, then slice and dice: Comprehensive stroke center management of cervical and intracranial emboli.

    Directory of Open Access Journals (Sweden)

    Jason D Hinman

    2013-07-01

    Full Text Available BACKGROUND AND PURPOSE: Tandem acute thrombotic emboli in the cervical and intracranial arteries are an unusual case of stroke presenting unique management challenges. In regional systems of acute stroke care anchored by Comprehensive Stroke Centers, combined fibrinolytic, endovascular, and open surgical intervention is a new therapeutic option. SUMMARY OF CASE: A 28 year old male underwent retinal surgery, including post-operative neck compression and the next day presented to a primary stroke center with aphasia and right hemiplegia. Intravenous tissue plasminogen activator therapy was initiated and the patient was transferred to a comprehensive stroke center (CSC for higher level of care (drip and ship. Imaging at the CSC demonstrated tandem thrombi: a near occlusive lesion at the origin of the left cervical internal carotid artery and a total occlusion of the M1 segment of the left middle cerebral artery. Endovascular thrombectomy with the Solitaire stent retriever resulted in intracranial recanalization (grip. Immediately after the endovascular procedure, open carotid thrombectomy was performed to achieve cervical carotid revascularization without systemic heparinization (slice. Both cervical carotid and intracranial thrombi were processed for proteomic analysis via mass spectrometry (dice. CONCLUSION: Combined fibrinolytic, endovascular, and open surgical intervention can yield revascularization and good clinical outcome in cases of tandem lesions.

  11. Degree, but not direction of grip strength asymmetries, is related to depression and anxiety in an elderly population.

    Science.gov (United States)

    Yu, Junhong; Rawtaer, Iris; Mahendran, Rathi; Kua, Ee-Heok; Feng, Lei

    2017-05-01

    Despite the abundance of studies on asymmetries in manual laterality, a marker for atypical brain lateralization in depression and anxiety, findings in this area are mixed. Traditionally, research have looked at individual differences in depression and anxiety as a function of the direction of asymmetry. However, recent research has emphasized on studying the degree of asymmetry in addition to its direction. To these ends, the present study aims to unravel the associations between the degree and direction of manual lateralization, and depression/anxiety. Cognitively healthy elderlies (N = 326, 91 males, Mage = 68) were administered grip strength assessments on both hands and self-report measures of depression and anxiety. Partial correlation analyses controlling for age, education and sex revealed significant positive associations between degree of lateralization and anxiety in the overall sample and among right-dominant participants, as well as a significant positive relationship between degree of lateralization and depression among right-dominant participants. None of the correlations involving the direction of lateralization yielded significance, neither was there significant differences between left- and right-dominant participants on depression and anxiety scores. These findings suggest that the degree of manual lateralization, but not direction, is related to depression and anxiety at least among right-dominant individuals.

  12. Comparison of hand grip strength and upper limb pressure pain threshold between older adults with or without non-specific shoulder pain

    Science.gov (United States)

    2017-01-01

    Background There is a high prevalence of non-specific shoulder pain associated with upper limb functional limitations in older adults. The purpose of this study was to determine the minimal clinically important differences (MCID) of grip strength and pressure pain threshold (PPT) in the upper limb between older adults with or without non-specific shoulder pain. Methods A case-control study was carried out following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria. A sample of 132 shoulders (mean ± SD years) with (n = 66; 76.04 ± 7.58) and without (n = 66; 75.05 ± 6.26) non-specific pain were recruited. The grip strength and PPT of the anterior deltoid and extensor carpi radialis brevis (ECRB) muscles were assessed. Results There were statistically significant differences (mean ± SD; P-value) for anterior deltoid PPT (2.51 ± 0.69 vs 3.68 ± 0.65, kg/cm2; P PPT (2.20 ± 0.60 vs 3.35 ± 0.38 kg/cm2; P PPT, ECRB PPT and grip strength, respectively, to assess the upper limb of older adults with non-specific shoulder pain after treatment. In addition, univariate and multivariate (linear regression and regression trees) analyses may be used to consider age distribution, sex, pain intensity, grip strength and PPT in older adults including clinical and epidemiological studies with non-specific shoulder pain. PMID:28289561

  13. Short Physical Performance Battery, usual gait speed, grip strength and Vulnerable Elders Survey each predict functional decline among older women with breast cancer.

    Science.gov (United States)

    Owusu, Cynthia; Margevicius, Seunghee; Schluchter, Mark; Koroukian, Siran M; Berger, Nathan A

    2017-09-01

    To determine the ability of three performance-based measures [Short Physical Performance Battery (SPPB), gait speed, and Grip Strength] and a self-report measure [Vulnerable Elders Survey (VES-13)] to predict functional decline among older women with breast cancer. Longitudinal data from a study of women ≥65years, with newly diagnosed stages I-III breast cancer, recruited from ambulatory oncology clinics between July 2010 and April 2014, was used. The primary outcome was functional decline, Yes or No, defined as a decrease in ≥1-point from baseline to 12months, on Activities of Daily Living Scales. Multivariable logistic regression and receiver operator curve analyses were conducted. Among 123 participants 18 (15%) developed functional decline. The predictive abilities for measures were: SPPB [Adjusted odds ratio (AOR)=1.65 per unit decrease in scores, 95% confidence interval (CI)=1.33-2.05; area under the receiver operator curve (AUC)=0.93; sensitivity=94%, specificity=80%]; gait speed (AOR=1.76 per unit increase in usual walking time, CI=1.29-2.41; AUC=0.93; sensitivity=87%, specificity=79%); VES-13 (AOR=1.64 per unit increase in scores, CI=1.31-2.05; AUC=0.87; sensitivity=83%, specificity=84%); and grip strength: (AOR=1.18 per unit decrease in grip strength, CI=1.06-1.30; AUC=0.80; sensitivity=67%, specificity=77%). SPPB, gait speed, grip strength and VES-13 all demonstrated excellent predictive abilities for functional decline. Larger studies are warranted to confirm the utility of these measures for identifying older adults with cancer at increased risk for functional decline, who may then be targeted for studies to explore the effects of interventions to improve function. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Management Tools

    Science.gov (United States)

    1987-01-01

    Manugistics, Inc. (formerly AVYX, Inc.) has introduced a new programming language for IBM and IBM compatible computers called TREES-pls. It is a resource management tool originating from the space shuttle, that can be used in such applications as scheduling, resource allocation project control, information management, and artificial intelligence. Manugistics, Inc. was looking for a flexible tool that can be applied to many problems with minimal adaptation. Among the non-government markets are aerospace, other manufacturing, transportation, health care, food and beverage and professional services.

  15. Changes in pain, dysfunction, and grip strength of patients with acute lateral epicondylitis caused by frequency of physical therapy: a randomized controlled trial.

    Science.gov (United States)

    Lee, Soyoung; Ko, Youngjun; Lee, Wanhee

    2014-07-01

    [Purpose] The purpose of this study was to investigate the changes in pain, dysfunction, and grip strength of patients with acute lateral epicondylitis and to suggest the appropriate treatment frequency and period. [Subjects] The subjects were divided into three: 2 days per week group (n=12), 3 days per week group (n=15), and 6 days per week group (n=13). [Methods] All groups received conventional physical therapy for 40 minutes and therapeutic exercises for 20 minutes per session during 6 weeks. The outcome measurements were the visual analogue scale (VAS), Patient-Rated Tennis Elbow Evaluation (PRTEE), and grip strength. [Results] The results of this study were as follows: at 3 weeks, there were no significant differences in VAS and PRTEE in the 3 groups, but at 6 weeks, 6 days per week group significantly decreased these two outcomes. Grip strength was significantly increased in 3 and 6 days per week groups at 6 weeks. [Conclusion] In conclusion, physical therapy is needed 3 days per week for 3 weeks in patients with acute lateral epicondylitis. After 3 weeks, 6 days per week is the most effective treatment frequency.

  16. Sustained effect of resistance training on blood pressure and hand grip strength following a detraining period in elderly hypertensive women: a pilot study

    Science.gov (United States)

    Nascimento, Dahan da Cunha; Tibana, Ramires Alsamir; Benik, Franklin M; Fontana, Keila Elizabeth; Neto, Frederico Ribeiro; de Santana, Frederico Santos; Santos-Neto, Leopoldo; Silva, Renato André Sousa; Silva, Alessandro Oliveira; Farias, Darlan Lopes; Balsamo, Sandor; Prestes, Jonato

    2014-01-01

    Introduction Hypertension is the most prevalent modifiable risk factor with a high prevalence among older adults. Exercise is a nonpharmacological treatment shown to benefit all patients with hypertension. Objective This study examined the effects of a 14-week moderate intensity resistance training program (RT) on the maintenance of blood pressure and hand grip strength during an extended detraining period in elderly hypertensive women. Methods Twelve hypertensive sedentary elderly women completed 14 weeks of whole body RT at a moderate perceived exertion following a detraining period of 14 weeks. Results Following the training period, participants demonstrated an increase in absolute hand grip strength (P=0.001), relative hand grip strength (P=0.032) and a decrease of systolic (P=0.001), diastolic (P=0.008), and mean blood pressure (P=0.002) when compared to pre-exercise values. In addition, these effects were sustained after 14 weeks of detraining. Conclusion Resistance training may be a valuable method to improve muscular strength and blood pressure in elderly people with benefits being maintained up to 14 weeks following training cessation. PMID:24477221

  17. Abrupt climatic changes on the Tibetan Plateau during the Last Ice Age——Comparative study of the Guliya ice core with the Greenland GRIP ice core

    Institute of Scientific and Technical Information of China (English)

    姚檀栋

    1999-01-01

    Based on a comparative study of the Gtdiya ice core with the Greenland GRIP ice core, the abrupt climatic changes on the Tibetan Plateau during the Last Ice Age have been examined. The major stadial-interstadial events and 7 warm events (BrΦrump, Odderade, Oerel, Glinde, Hengelo, Denekamp, BΦlling) are consistent in the two ice cores. However, there are some unique features in the Guliya ice core records. The transition from warm to cold periods in the Guliya ice core is faster than that in the Greenland GRIP ice core. The magnitude of the climatic changes in the Guliya ice core is also larger than that in the Greenland GRIP ice core. Another significant feature of the Guliya ice core records is that there is a series of cycles of about 200 a from 18 to 35 kaBP. 22 warm events and 20 cold events with a fluctuation magnitude of 7℃ have been distinguished. The warm and cold events with a fluctuation magnitude within 3℃ are as high as 100. It is speculated that the abrupt climatic changes in different

  18. Laparoscopic Totally Extraperitoneal Groin Hernia Repair Using a Self-Gripping Mesh: Clinical Results of 235 Primary and Recurrent Groin Hernias.

    Science.gov (United States)

    Ozmen, John; Choi, Vincent; Hepburn, Kirsten; Hawkins, Will; Loi, Ken

    2015-11-01

    Compared with open surgery, laparoscopic groin hernia repair has been shown to significantly reduce postoperative pain. However, chronic pain remains a problem with the laparoscopic approach, affecting approximately 10% of patients. The purpose of this study was to evaluate clinical outcomes following the use of Parietex ProGrip™ (Covidien, Dublin, Ireland) self-gripping mesh during laparoscopic totally extraperitoneal groin hernia repair. Data were collected prospectively from 145 male and 15 female patients with 235 inguinal hernias. All patients underwent repair by the laparoscopic totally extraperitoneal approach using Parietex ProGrip mesh. During follow-up ranging from 5 to 24 months, complications, pain score, patient satisfaction, and recurrence were analyzed. All patients were discharged on the day of surgery or the next morning. There were no immediate complications or returns to the operating room. Delayed postoperative complications included minor bruising to the genital region (3 cases), hematoma/seroma (1 case), and wound infection (1 case). The mean follow-up was 15 months, at which time there were no reports of hernia recurrence and 99% of patients were satisfied with their hernia repair. One patient (0.63%) reported severe pain (numeric rating scale score of >7), and 4 patients (2.5%) reported intermittent mild pain on exertion. The results of this study suggest that the use of a self-gripping mesh during the laparoscopic totally extraperitoneal approach is a promising and effective technique for repairing both primary and recurrent inguinal hernias.

  19. Long-term outcome of muscle strength in ulnar and median nerve injury: Comparing manual muscle strength testing, grip and pinch strength dynamometers and a new intrinsic muscle strength dynamometer

    OpenAIRE

    Schreuders, Ton; Roebroeck, Marij; Jaquet, Jean; Hovius, Steven; Stam, Henk

    2004-01-01

    textabstractObjective: To compare the outcome of muscle strength with manual muscle strength testing grip and pinch strength measurements and a dynamometer which allows for measurements of the intrinsic muscles of the hand in isolation (the Rotterdam Intrinsic Hand Myometer, RIHM). Methods: Thirty-four patients more than 2 years after ulnar and/or median nerve injury. Muscle strength was evaluated using manual muscle strength testing (MMST), grip, pinch and intrinsic muscle strength measureme...

  20. Efeito da preensão manual sobre o equilíbrio de judocas Effect of hand grip on the balance of judokas

    Directory of Open Access Journals (Sweden)

    Jonathan Ache Dias

    2011-06-01

    Full Text Available O objetivo deste estudo foi verificar se existe efeito da preensão manual máxima (o ato de realizar ou não a preensão sobre o controle do equilíbrio de judocas em postura restrita, além de verificar se existe correlação entre a força de preensão manual (FPM e o controle do equilíbrio. Foram avaliados sete judocas com um dinamômetro e uma plataforma estabilométrica sendo mensuradas, concomitantemente, a FPM e o centro de pressão (CP. Foi verificado que até 80% da variabilidade do CP pode ser atrelada a preensão manual indicando que a mesma gera perturbações no controle do equilíbrio. Entretanto, foram encontradas correlações (r = 0,348 até 0,816 entre a FPM e o deslocamento do CP. Com isso pode-se concluir que, apesar da preensão manual gerar perturbações no equilíbrio, seu comportamento parece estar relacionado com os movimentos do corpo realizados para manter o equilíbrio, indicando uma possível correlação entre esses fenômenos.The purpose of this study was to verify if there is an effect of maximum hand grip (the act of performing or not the hand grip on the balance control of judokas in a restrict posture, and also to verify if there is a correlation between the hand grip strength (HGS and the balance control. Seven judokas were evaluated with a dynamometer and a stabilometric force platform, being measured, at the same time, the HGS and the center of pressure (COP. It was found that up to 80% of the COP variability was related to the hand grip demonstrating that it generates perturbations to the balance control. However, It was found correlations (r = 0,348 to 0,816 between de HGS and de COP displacement. With that, it can be concluded that, despite the hand grip generating perturbation on the balance, its behavior appears to be related to the body movements performed to sustain balance, indicating a possible correlation between this phenomenons.

  1. Comparison of hand grip strength and upper limb pressure pain threshold between older adults with or without non-specific shoulder pain

    Directory of Open Access Journals (Sweden)

    Cesar Calvo Lobo

    2017-02-01

    Full Text Available Background There is a high prevalence of non-specific shoulder pain associated with upper limb functional limitations in older adults. The purpose of this study was to determine the minimal clinically important differences (MCID of grip strength and pressure pain threshold (PPT in the upper limb between older adults with or without non-specific shoulder pain. Methods A case-control study was carried out following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE criteria. A sample of 132 shoulders (mean ± SD years with (n = 66; 76.04 ± 7.58 and without (n = 66; 75.05 ± 6.26 non-specific pain were recruited. The grip strength and PPT of the anterior deltoid and extensor carpi radialis brevis (ECRB muscles were assessed. Results There were statistically significant differences (mean ± SD; P-value for anterior deltoid PPT (2.51 ± 0.69 vs 3.68 ± 0.65, kg/cm2; P < .001, ECRB PPT (2.20 ± 0.60 vs 3.35 ± 0.38 kg/cm2; P < .001 and grip strength (20.78 ± 10.94 vs 24.63 ± 9.38 kg; P = .032 between shoulders with and without non-specific pain, respectively. Discussion The MCID of 1.17 kg/cm2, 1.15 kg/cm2 and 3.84 kg were proposed for anterior deltoid PPT, ECRB PPT and grip strength, respectively, to assess the upper limb of older adults with non-specific shoulder pain after treatment. In addition, univariate and multivariate (linear regression and regression trees analyses may be used to consider age distribution, sex, pain intensity, grip strength and PPT in older adults including clinical and epidemiological studies with non-specific shoulder pain.

  2. Mathematical tools

    Science.gov (United States)

    Capozziello, Salvatore; Faraoni, Valerio

    In this chapter we discuss certain mathematical tools which are used extensively in the following chapters. Some of these concepts and methods are part of the standard baggage taught in undergraduate and graduate courses, while others enter the tool-box of more advanced researchers. These mathematical methods are very useful in formulating ETGs and in finding analytical solutions.We begin by studying conformal transformations, which allow for different representations of scalar-tensor and f(R) theories of gravity, in addition to being useful in GR. We continue by discussing variational principles in GR, which are the basis for presenting ETGs in the following chapters. We close the chapter with a discussion of Noether symmetries, which are used elsewhere in this book to obtain analytical solutions.

  3. Serotonin and Histamine Therapy Increases Tetanic Forces of Myoblasts, Reduces Muscle Injury, and Improves Grip Strength Performance of Dmdmdx Mice

    Directory of Open Access Journals (Sweden)

    Volkan Gurel

    2015-11-01

    Full Text Available Duchenne muscular dystrophy (DMD is a recessive X-linked fatal disorder caused by a mutation in the dystrophin gene. Although several therapeutic approaches have been studied, none has led to substantial long-term effects in patients. The aim of this study was to test a serotonin and histamine (S&H combination on human skeletal myoblasts and Dmdmdx mice for its effects on muscle strength and injury. Normal human bioartificial muscles (BAMs were treated, and muscle tetanic forces and muscle injury tests were performed using the MyoForce Analysis System. Dmdmdx mice, the murine model of DMD, were administered serotonin, histamine, or S&H combination twice daily for 6 weeks, and functional performance tests were conducted once a week. The S&H combination treatment caused significant increases in tetanic forces at all time points and concentrations tested as compared to the saline controls. Dose response of the BAMs to the treatment demonstrated a significant increase in force generation at all concentrations compared to the controls after 3 to 4 days of drug treatment. The highest 3 concentrations had a significant effect on lowering contractile-induced injury as measured by a reduction in the release of adenylate kinase. Histamine-only and S&H treatments improved grip strength of Dmdmdx mice, whereas serotonin-only treatment resulted in no significant improvement in muscle strength. The results of this study indicate that S&H therapy might be a promising new strategy for muscular dystrophies and that the mechanism should be further investigated.

  4. Tool Gear: Infrastructure for Parallel Tools

    Energy Technology Data Exchange (ETDEWEB)

    May, J; Gyllenhaal, J

    2003-04-17

    Tool Gear is a software infrastructure for developing performance analysis and other tools. Unlike existing integrated toolkits, which focus on providing a suite of capabilities, Tool Gear is designed to help tool developers create new tools quickly. It combines dynamic instrumentation capabilities with an efficient database and a sophisticated and extensible graphical user interface. This paper describes the design of Tool Gear and presents examples of tools that have been built with it.

  5. Setting a chronology for the basal ice at Dye-3 and GRIP: Implications for the long-term stability of the Greenland Ice Sheet

    Science.gov (United States)

    Yau, Audrey M.; Bender, Michael L.; Blunier, Thomas; Jouzel, Jean

    2016-10-01

    The long-term stability of the Greenland Ice Sheet (GIS) is an important issue in our understanding of the climate system. Limited data suggest that the northern and southern sections extend well back into the Pleistocene, but most age constraints do not definitively date the ice. Here, we re-examine the GRIP and Dye-3 ice cores to provide direct ice core observations as to whether the GIS survived previous interglacials known to be warmer (˜130 ka) or longer (˜430 ka) than the present interglacial. We present geochemical analyses of the basal ice from Dye-3 (1991-2035 m) and GRIP (3020-3026 m) that characterize and date the ice. We analyzed the elemental and isotopic composition of O2, N2, and Ar, of trapped air in these two cores to assess the origin of trapped gases in silty ice. Dating of the trapped air was then achieved by measuring the paleoatmospheric δ40Ar/38Ar and the 17O anomaly (17Δ) of O2. The resulting age is a lower limit because the trapped air may be contaminated with crustal radiogenic 40Ar. The oldest average age of replicates measured at various depths is 970 ± 140 ka for the GRIP ice core and 400 ka ± 170 ka for Dye-3. 17Δ data from Dye-3 also argue strongly that basal ice in this core predates the Eemian. This confirms that the Greenland Ice Sheet did not completely melt at Southern Greenland during the last interglacial, nor did it completely melt at Summit Greenland during the unusually long interglacial ˜430 kyr before present.

  6. Grip op virussen

    NARCIS (Netherlands)

    Vlugt, van der R.A.A.; Verbeek, M.; Roenhorst, A.; Botermans, M.; Kock, de M.J.D.; Schadewijk, van T.; Miglino, R.; Kormelink, R.; Lent, van J.W.M.

    2011-01-01

    Aan het begin van het FES-project ‘Versterking infrastructuur plantgezondheid' zijn de belangrijkste knelpunten op plantenvirologisch gebied in Nederland geïnventariseerd. Criteria hierbij waren vooral fytosanitaire status, economisch belang en de behoefte aan betrouwbare detectie- en identificatiem

  7. Malaria's deadly grip

    DEFF Research Database (Denmark)

    Smith, Joseph D; Rowe, J Alexandra; Higgins, Matthew K

    2013-01-01

    Cytoadhesion of Plasmodium falciparum-infected erythrocytes to host microvasculature is a key virulence determinant. Parasite binding is mediated by a large family of clonally variant adhesion proteins, termed P. falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by var genes and expressed...... at the infected erythrocyte surface. Although PfEMP1 proteins have extensively diverged under opposing selection pressure to maintain ligand binding while avoiding antibody-mediated detection, recent work has revealed they can be classified into different groups based on chromosome location and domain composition......EMP1 subtypes appear to be specialized for infection of malaria naïve hosts. Here, we discuss recent findings on the origins and evolution of the var gene family, the structure-function of PfEMP1 proteins, and a distinct subset of PfEMP1 variants that have been associated with severe childhood malaria....

  8. Radiation accident grips Goiania

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, L.

    1987-11-20

    On 13 September two young scavengers in Goiania, Brazil, removed a stainless steel cylinder from a cancer therapy machine in an abandoned clinic, touching off a radiation accident second only to Chernobyl in its severity. On 18 September they sold the cylinder, the size of a 1-gallon paint can, to a scrap dealer for $25. At the junk yard an employee dismantled the cylinder and pried open the platinum capsule inside to reveal a glowing blue salt-like substance - 1400 curies of cesium-137. Fascinated by the luminescent powder, several people took it home with them. Some children reportedly rubbed in on their bodies like carnival glitter - an eerie image of how wrong things can go when vigilance over radioactive materials lapses. In all, 244 people in Goiania, a city of 1 million in central Brazil, were contaminated. The eventual toll, in terms of cancer or genetic defects, cannot yet be estimated. Parts of the city are cordoned off as radiation teams continue washing down buildings and scooping up radioactive soil. The government is also grappling with the political fallout from the accident.

  9. Grip op virussen

    OpenAIRE

    Vlugt, van der, R.A.A.; Verbeek, M.; Roenhorst, A.; Botermans, M.; Kock, de, M.J.D.; Schadewijk, van, R.; Miglino, R.; Kormelink, R.; Lent, van, J.W.M.

    2011-01-01

    Aan het begin van het FES-project ‘Versterking infrastructuur plantgezondheid' zijn de belangrijkste knelpunten op plantenvirologisch gebied in Nederland geïnventariseerd. Criteria hierbij waren vooral fytosanitaire status, economisch belang en de behoefte aan betrouwbare detectie- en identificatiemethoden. Op basis hiervan is een prioriteitenlijst opgesteld van de (gereguleerde) virussen uit de volgende virusgroepen: Potyvirussen, Nepovirussen, Tospovirussen en Potexvirussen. Daarnaast werd ...

  10. Short Term Microgravity Effect on Isometric Hand Grip and Precision Pinch Force with Visual and Propioceptive Feedback

    Science.gov (United States)

    Pastacaldi, P.; Bracciaferri, F.; Neri, G.; Porciani, M.; Zolesi, V.

    Experiments executed on the upper limb are assuming increasing significance in the frame of the Human Physiology in space, for at least two reasons: -the upper limb is the principal means of locomotion for the subject living in aspace station -fatigue can have a significant effect the hand, for the ordinary work on board,and in particular for the extra-vehicular activities. The degradation of the performances affecting the muscular-skeletal apparatus can be easily recognized on the upper limb, by exerting specific scientific protocols, to be repeated through the permanence of the subject in weightlessness conditions. Also, the effectiveness of adequate counter-measures aimed to the reduction of calcium and muscular mass need to be verified, by means of specific assessments on the upper limb. Another aspect relevant to the effect of microgravity on the upper limb is associated with the alteration of the motor control programs due to the different gravity factor, affecting not only the bio-mechanics of the subject, but in general all his/her psycho- physical conditions, induced by the totally different environment. Specific protocols on the upper limb can facilitate the studies on learning mechanisms for the motor control. The results of such experiments can be transferred to the Earth, useful for treatment of subjects with local traumas or diseases of the Central Nervous System.In the frame of the mission of the Italian astronaut Roberto Vittori on board the International Space Station (ISS), the Italian Space Agency (ASI) has promoted the program "Marco Polo", with a number of experiments devoted to the study of the effect of microgravity on the human body. The experiment CHIRO ("Crew's Health: Investigation on Reduced Operability) is a part of the program. Its purpose is the determination of the influence of the altered gravity on the control of the grip force exerted by the hand or by a group of fingers and the adaptive behavior of this control through the

  11. Evaluating the flux of extraterrestrial osmium at the onset of Younger Dryas in the GRIP ice core

    Science.gov (United States)

    Seo, J. H.; Han, C.; Hong, S.; Steffensen, J. P.; Sharma, M.

    2016-12-01

    The Younger Dryas (YD: 12.9-11.6 ka) was an abrupt cooling event during the last deglaciation. The mechanism behind the cooling is suggested to be a temporary slowdown of North Atlantic thermohaline circulation due to catastrophic release of meltwater from proglacial Lake Agassiz during the retreat of the Laurentide Ice Sheet [1]. An alternative hypothesis states that the cooling was directly/indirectly triggered by one or more cosmic airbursts/impacts [2]. While several papers have documented evidence for a YD extraterrestrial impact including microspherules, nanodiamonds, magnetic grains, and glass-like carbon [4-7], this hypothesis remains controversial [8-10]. In a recent study by Petaev et al. [11], an unusually high Pt/Ir ratio of 1200 was discovered in the GISP-2 ice core at the onset of YD, indicating a large Pt enriched iron meteorite impact. Such a high Pt/Ir in extraterrestrial materials has not been documented [12]. Thus, Petaev et al. [11] acknowledge that the interpretation of the Pt anomaly is based on circumstantial evidence. The distinct Os isotopic composition (187Os/188Os ratio) of the terrestrial (=1.26) and extraterrestrial (= 0.13) sources should allow us to evaluate if there was a meteorite impact at the YD boundary. These analyses are technically challenging owing to rather low concentration of Os in ice-melts ( 1x10-15g/g). Here, we will present Os isotope data from the GRIP ice core spanning the time period through YD to shed light on the meteorite/comet impact hypothesis. [1] Broecker et al. (1989) Nature 341, 318-321; [2] Firestone et al. (2007) PNAS. 104, 16016-16021; [3] Bunch et al. (2012) PNAS. 109, 1903-1912; [4] LeCompte et al. (2012) PNAS. 109, 2960-2969; [5] Wittke et al. (2013) PNAS 110, 2088-2097; [6] Wu et al. (2013) PNAS. 110, 3557-3566; [7] Kennett et al. (2015) PNAS 112, E4344-E4353; [8] Pinter et al. (2011) Earth Sci. Rev., 106, 247-264; [9] Holliday et al. (2014) J. Quat. Sci. 29, 515-530; [10] Meltzer et al. (2014) PNAS

  12. A novel gripper design for multi hand tools grasping under tight clearance constraints and external torque effect

    KAUST Repository

    Shaqura, Mohammad

    2017-08-29

    A robotic multi tool gripper design and implementation is presented in this paper. The proposed design targets applications where an actuation task is performed using a wide selection of standard hand tools. The manipulation motion is assumed to be rotational which requires a firm grip to account for external torque on the grasped tool. The setup is assumed to be a conventional workshop panel with hand tools being hanged close to each other, which constraints lateral clearance around the target, and near the wall of the panel, which constraints the depth clearance. Off the shelf grippers are mostly heavy and bulky which make them unsuitable for these requirements. Moreover, they are not optimized in terms of power consumption, simplicity and compactness. These generic grippers are mostly designed for pick and place tasks where no external torques other than those caused by the object weight affects the gripper. The design challenge involves building a gripper that is capable of operating in limited clearance space, firmly grip a variety of standard hand tools with different sizes and shapes. The proposed design is optimized for these objectives and offers a low cost and power consumption solution. The design has been validated in lab and outdoor experiments and has been deployed in real operating platform used in an international robotics competition.

  13. Comparison of pressure pain threshold, grip strength,dexterity and touch pressure of dominant and non-dominant hands within and between right-and left-handed subjects.

    Science.gov (United States)

    Ozcan, Ayse; Tulum, Zeliha; Pinar, Lamia; Başkurt, Ferdi

    2004-12-01

    This study was done to evaluate differences in pressure pain threshold, grip strength, manual dexterity and touch pressure threshold in the dominant and non-dominant hands of right- and left-handed subjects, and to compare findings within and between these groups. Thirty-nine right-handed and twenty-one left-handed subjects participated in the study. Pressure pain threshold was assessed using a dolorimeter, grip strength was assessed with a hand-grip dynamometer, manual dexterity was evaluated using the VALPAR Component Work Sample-4 system, and touch pressure threshold was determined using Semmes Weinstein monofilaments. Results for the dominant and non-dominant hands were compared within and between the groups. In the right-handed subjects, the dominant hand was significantly faster with the VALPAR Component Work Sample-4, showed significantly greater grip strength, and had a significantly higher pressure pain threshold than the non-dominant hand. The corresponding results for the two hands were similar in the left-handed subjects. The study revealed asymmetrical manual performance in grip strength, manual dexterity and pressure pain threshold in right-handed subjects, but no such asymmetries in left-handed subjects.

  14. Short-Term Effects of Whole-Body Vibration Combined with Task-Related Training on Upper Extremity Function, Spasticity, and Grip Strength in Subjects with Poststroke Hemiplegia: A Pilot Randomized Controlled Trial.

    Science.gov (United States)

    Lee, Jung-Sun; Kim, Chang-Yong; Kim, Hyeong-Dong

    2016-08-01

    The aim of this study was to determine the effect of whole-body vibration training combined with task-related training on arm function, spasticity, and grip strength in subjects with poststroke hemiplegia. Forty-five subjects with poststroke were randomly allocated to 3 groups, each with 15 subjects as follows: control group, whole-body vibration group, and whole-body vibration plus task-related training group. Outcome was evaluated by clinical evaluation and measurements of the grip strength before and 4 weeks after intervention. Our results show that there was a significantly greater increase in the Fugl-Meyer scale, maximal grip strength of the affected hand, and grip strength normalized to the less affected hand in subjects undergoing the whole-body vibration training compared with the control group after the test. Furthermore, there was a significantly greater increase in the Wolf motor function test and a decrease in the modified Ashworth spasticity total scores in subjects who underwent whole-body vibration plus task-related training compared with those in the other 2 groups after the test. The findings indicate that the use of whole-body vibration training combined with task-related training has more benefits on the improvement of arm function, spasticity, and maximal grip strength than conventional upper limb training alone or with whole-body vibration in people with poststroke hemiplegia.

  15. Coming to grips with challenging behaviour: a cluster randomised controlled trial on the effects of a new care programme for challenging behaviour on burnout, job satisfaction and job demands of care staff on dementia special care units.

    Science.gov (United States)

    Zwijsen, S A; Gerritsen, D L; Eefsting, J A; Smalbrugge, M; Hertogh, C M P M; Pot, A M

    2015-01-01

    Caring for people with dementia in dementia special care units is a demanding job. Challenging behaviour is one of the factors influencing the job satisfaction and burnout of care staff. A care programme for the challenging behaviour of nursing home residents with dementia might, next to diminishing the challenging behaviour of residents, improve job satisfaction and reduce the care staff's feelings of burnout. To determine the effects of a care programme for the challenging behaviour of nursing home residents with dementia on the burnout, job satisfaction and job demands of care staff. The care programme was implemented according to a stepped wedge design in which care units were randomly divided over five groups with different time points of starting with implementation. 17 Dutch dementia special care units. Care staff members of the 17 units. The care programme consists of an education package and of various structured assessment tools that guide professionals through the multidisciplinary detection, analysis, treatment and evaluation of treatment of challenging behaviour. Burnout, job satisfaction and job demands were measured before implementation, halfway through the implementation process and after all the care units had implemented the care programme. Burnout was measured with the Dutch version of the Maslach burnout inventory (UBOS-C, three subscales); job satisfaction and job demands were measured with subscales of the Leiden Quality of Work Questionnaire. Mixed model analyses were used to determine effects. Care staff could not be blinded for the intervention. Of the 1441 questionnaires, 645 were returned (response 45%, 318 control measurements, 327 intervention measurements) by 380 unique care staff members. Significant effects were found on job satisfaction (0.93, 95% CI 0.48-1.38). On the other outcomes, no significant changes in the scores were found. Positive effects of using the Grip on Challenging behaviour care programme were found on job

  16. Confined Tube Crimp Using Portable Hand Tools

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, Joseph James [Los Alamos National Laboratory; Pereyra, R. A. [LANL Retired; Archuleta, Jeffrey Christopher [Los Alamos National Laboratory; Martinez, Isaac P. [Los Alamos National Laboratory; Nelson, A. M. [MST-16 Summer Student (2007); Allen, Ronald Scott [Los Alamos National Laboratory; Page, R. L. [LANL Retired; Freer, Jerry Eugene [Los Alamos National Laboratory; Dozhier, Nathan Gus [Los Alamos National Laboratory

    2016-04-04

    The Lawrence Radiation Laboratory developed handheld tools that crimp a 1/16 inch OD tube, forming a leak tight seal1 (see Figure 1). The leak tight seal forms by confining the 1/16 inch OD tubing inside a die while applying crimp pressure. Under confined pressure, the tube walls weld at the crimp. The purpose of this study was to determine conditions for fabricating a leak tight tube weld. The equipment was used on a trial-and-error basis, changing the conditions after each attempt until successful welds were fabricated. To better confine the tube, the die faces were polished. Polishing removed a few thousandths of an inch from the die face, resulting in a tighter grip on the tubing wall. Using detergent in an ultrasonic bath, the tubing was cleaned. Also, the time under crimp pressure was increased to 30 seconds. With these modifications, acceptable cold welds were fabricated. After setting the conditions for an acceptable cold weld, the tube was TIG welded across the crimped face.

  17. Understanding end-of-life caring practices in the emergency department: developing Merleau-Ponty's notions of intentional arc and maximum grip through praxis and phronesis.

    Science.gov (United States)

    Chan, Garrett K

    2005-01-01

    The emergency department (ED) is a fast-paced, highly stressful environment where clinicians function with little or suboptimal information and where time is measured in minutes and hours. In addition, death and dying are phenomena that are often experienced in the ED. Current end-of-life care models, based on chronic illness trajectories, may be difficult to apply in the ED. A philosophical approach examining end-of-life care may help us understand how core medical and nursing values are embodied as care practices and as ethical comportment. The integration of Aristotle's notions of phronesis and praxis with Merleau-Ponty's ontological notions of intentional arc and maximum grip in the context of the culture and practices of the ED offers a unique view of clinical and ethical practice at the end-of-life in the emergency setting. Caring for people at the end-of-life calls us to act virtuously based on previous experience, meanings and local practices. The maximum grip of the ultimate particulars of the situation combined with one's experiential and theoretical knowledge opens up situated possibilities for the expert clinician.

  18. Analysis of the pen pressure and grip force signal during basic drawing tasks: The timing and speed changes impact drawing characteristics.

    Science.gov (United States)

    Gatouillat, Arthur; Dumortier, Antoine; Perera, Subashan; Badr, Youakim; Gehin, Claudine; Sejdić, Ervin

    2017-08-01

    Writing is a complex fine and trained motor skill, involving complex biomechanical and cognitive processes. In this paper, we propose the study of writing kinetics using three angles: the pen-tip normal force, the total grip force signal and eventually writing quality assessment. In order to collect writing kinetics data, we designed a sensor collecting these characteristics simultaneously. Ten healthy right-handed adults were recruited and were asked to perform four tasks: first, they were instructed to draw circles at a speed they considered comfortable; they then were instructed to draw circles at a speed they regarded as fast; afterwards, they repeated the comfortable task compelled to follow the rhythm of a metronome; and eventually they performed the fast task under the same timing constraints. Statistical differences between the tasks were computed, and while pen-tip normal force and total grip force signal were not impacted by the changes introduced in each task, writing quality features were affected by both the speed changes and timing constraint changes. This verifies the already-studied speed-accuracy trade-off and suggest the existence of a timing constraints-accuracy trade-off. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Tools for Manipulation and Characterisation of Nanostructures

    DEFF Research Database (Denmark)

    Mølhave, Kristian; Bøggild, Peter

    grippers, which were then successfully used for pick-and-place manipulation of silicon nanowires. For increased gripping force and control over the manipulation process, microfabricated grippers with integrated force-feedback were also demonstrated. Environmental electron beam deposition (EEBD...

  20. Grip strength measurements at two different wrist extension positions in chronic lateral epicondylitis-comparison of involved vs. uninvolved side in athletes and non athletes: a case-control study

    Directory of Open Access Journals (Sweden)

    Bhargava Arti S

    2010-09-01

    Full Text Available Abstract Background Lateral epicondylitis is a common sports injury of the elbow caused due to altered muscle activation during repetitive wrist extension in many athletic and non-athletic endeavours. The amount of muscle activity and timing of contraction eventually is directly dependent upon joint position during the activity. The purpose of our study was to compare the grip strength in athletes with lateral epicondylalgia in two different wrist extension positions and compare them between involved and uninvolved sides of athletes and non-athletes. Methods An assessor-blinded case-control study of eight athletes and twenty-two non-athletes was done. The grip strength was measured using JAMAR® hand dynamometer in kilograms-force at 15 degrees (slightly extended and 35 degrees (moderately extended wrist extension positions (maintained by wrist splints on both involved and uninvolved sides of athletes and non-athletes with unilateral lateral epicondylitis of atleast 3 months duration. Their pain was to be elicited with local tenderness and two of three tests being positive- Cozen's, Mill's manoeuvre, resisted middle finger extension tests. For comparisons of grip strength, Wilcoxon signed rank test was used for within-group comparison (between 15 and 35 degrees wrist extension positions and Mann-Whitney U test was used for between-group (athletes vs. non-athletes comparisons at 95% confidence interval and were done using SPSS 11.5 for Windows. Results Statistically significant greater grip strength was found in 15 degrees (27.75 ± 4.2 kgms in athletes; 16.45 ± 4.2 kgms in non-athletes wrist extension than at 35 degrees (25.25 ± 3.53 kgm in athletes and 14.18 ± 3.53 kgm in non-athletes. The athletes had greater grip strength than non-athletes in each of test positions (11.3 kgm at 15 degrees and 11.07 kgm at 35 degrees measured. There was also a significant difference between involved and uninvolved sides' grip strength at both wrist

  1. Downhole tool with replaceable tool sleeve sections

    Energy Technology Data Exchange (ETDEWEB)

    Case, W. A.

    1985-10-29

    A downhole tool for insertion in a drill stem includes elongated cylindrical half sleeve tool sections adapted to be non-rotatably supported on an elongated cylindrical body. The tool sections are mountable on and removable from the body without disconnecting either end of the tool from a drill stem. The half sleeve tool sections are provided with tapered axially extending flanges on their opposite ends which fit in corresponding tapered recesses formed on the tool body and the tool sections are retained on the body by a locknut threadedly engaged with the body and engageable with an axially movable retaining collar. The tool sections may be drivably engaged with axial keys formed on the body or the tool sections may be formed with flat surfaces on the sleeve inner sides cooperable with complementary flat surfaces formed on a reduced diameter portion of the body around which the tool sections are mounted.

  2. Factors influencing power hand tool fastening accuracy and reaction forces.

    Science.gov (United States)

    Radwin, Robert G; Chourasia, Amrish O; Howery, Robert S; Fronczak, Frank J; Yen, Thomas Y; Subedi, Yashpal; Sesto, Mary E

    2014-06-01

    A laboratory study investigated the relationship between power hand tool and task-related factors affecting threaded fastener torque accuracy and associated handle reaction force. We previously developed a biodynamic model to predict handle reaction forces. We hypothesized that torque accuracy was related to the same factors that affect operator capacity to react against impulsive tool forces, as predicted by the model. The independent variables included tool (pistol grip on a vertical surface, right angle on a horizontal surface), fastener torque rate (hard, soft), horizontal distance (30 cm and 60 cm), and vertical distance (80 cm, 110 cm, and 140 cm). Ten participants (five male and five female) fastened 12 similar bolts for each experimental condition. Average torque error (audited - target torque) was affected by fastener torque rate and operator position. Torque error decreased 33% for soft torque rates, whereas handle forces greatly increased (170%). Torque error also decreased for the far horizontal distance 7% to 14%, when vertical distance was in the middle or high, but handle force decreased slightly 3% to 5%. The evidence suggests that although both tool and task factors affect fastening accuracy, they each influence handle reaction forces differently. We conclude that these differences are attributed to different parameters each factor influences affecting the dynamics of threaded faster tool operation. Fastener torque rate affects the tool dynamics, whereas posture affects the spring-mass-damping biodynamic properties of the human operator. The prediction of handle reaction force using an operator biodynamic model may be useful for codifying complex and unobvious relationships between tool and task factors for minimizing torque error while controlling handle force.

  3. Sustained effect of resistance training on blood pressure and hand grip strength following a detraining period in elderly hypertensive women: a pilot study

    Directory of Open Access Journals (Sweden)

    Nascimento D da C

    2014-01-01

    Full Text Available Dahan da Cunha Nascimento,1,5,8 Ramires Alsamir Tibana,1,8 Franklin M Benik,2 Keila Elizabeth Fontana,3 Frederico Ribeiro Neto,8 Frederico Santos de Santana,5,8 Leopoldo Santos-Neto,4 Renato André Sousa Silva,1,5,6 Alessandro Oliveira Silva,1,7 Darlan Lopes Farias,1,7 Sandor Balsamo,4,5,8 Jonato Prestes1 1Postgraduate Program in Physical Education, Catholic University of Brasilia, Brasilia, Brazil; 2Department of Kinesiology and Sports Studies Graduate Program, Eastern Illinois University, Charleston, IL, USA; 3Faculty of Physical Education, University of Brasilia, Brasilia, Brazil; 4Graduate Program in Medical Sciences of the University of Brasilia, School of Medicine and Rheumatology Service, University Hospital of Brasilia (HUB, Brasilia, Brazil; 5Department of Physical Education, University Center Euro American University Center, Brasilia, Brazil; 6Center of Excellence in Medicine of Exercise (CEMEx, Brasilia, Brazil; 7Center University of Brasilia (UNICEUB, Brasilia, Brazil; 8Strength Training and Health Research Group (GEPEEFS, Brasilia, Brazil Introduction: Hypertension is the most prevalent modifiable risk factor with a high prevalence among older adults. Exercise is a nonpharmacological treatment shown to benefit all patients with hypertension. Objective: This study examined the effects of a 14-week moderate intensity resistance training program (RT on the maintenance of blood pressure and hand grip strength during an extended detraining period in elderly hypertensive women. Methods: Twelve hypertensive sedentary elderly women completed 14 weeks of whole body RT at a moderate perceived exertion following a detraining period of 14 weeks. Results: Following the training period, participants demonstrated an increase in absolute hand grip strength (P=0.001, relative hand grip strength (P=0.032 and a decrease of systolic (P=0.001, diastolic (P=0.008, and mean blood pressure (P=0.002 when compared to pre-exercise values. In addition, these

  4. 基于人手抓握复现的欠驱动假手结构设计%Underactuated Prosthetic Hand Design Based on Manpower Grip Reproduction

    Institute of Scientific and Technical Information of China (English)

    何其佳; 赵京东; 刘源

    2016-01-01

    假手的运动拟人性主要体现在抓取过程中手指各个关节间的协同性上。根据神经学原理,人手完成一个抓握动作需要几十个肌肉协同作用。人手是假手设计的范本,将这个原理推广到假手中,通过2个电机的协同输入,实现四指12个关节的协同输出。协同的具体参数通过人手抓握数据采集的降维处理计算得出。在拟人假手的设计中,首次提出通过集成在手掌内部的微型行星齿轮来合成2路输入,实现协同控制。经过ADAMS仿真,本假手能够完成多种日常抓握姿势。%The anthropomorphic movement of a prosthetic hand is mainly reflected on the synergy a‐mong various joints of the fingers during the grabbing process .According to the principle in neurology ,a gripping action requires manpower to complete dozens of muscle synergies .Manpower is the template for prosthetic hand design .This principle will be extended to the prosthetic hand .Collaborative output of twelve joints of the four fingers is achieved by collaborative input of two motors .Specific parameters of the synergy are calculated by collection of hand gripping data and dimension reduction .The anthropomorphic prosthetic hand design first proposes that the integrated inside the palm of the minor planet gear can be used to synthesize two inputs to achieve cooperative control .According to the simulation of ADAMS ,the prosthetic hand can complete a variety of daily grip positions .

  5. Useful design tools?

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole

    2005-01-01

    vague and contested concept of sustainability into concrete concepts and building projects. It describes a typology of tools: process tools, impact assessment tools, multi-criteria tools and tools for monitoring. It includes a Danish paradigmatic case study of stakeholder participation in the planning...... of a new sustainable settlement. The use of design tools is discussed in relation to innovation and stakeholder participation, and it is stressed that the usefulness of design tools is context dependent....

  6. CoC GIS Tools (GIS Tool)

    Data.gov (United States)

    Department of Housing and Urban Development — This tool provides a no-cost downloadable software tool that allows users to interact with professional quality GIS maps. Users access pre-compiled projects through...

  7. Estimation of precipitation rates by measurements of {sup 36}Cl in the GRIP ice core with the PSI/ETH tandem accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, G.; Baumgartner, S.; Beer, J. [EAWAG, Duebendorf (Switzerland); Synal, H.A. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Suter, M. [Eidgenoessische Technische Hochschule, Zurich (Switzerland)

    1997-09-01

    Within the European Greenland ice core project (GRIP) {sup 36}Cl AMS measurements have been performed on ice core samples from Summit (Greenland, 73{sup o}N, 37{sup o}W). Most data analysed so far are from the lower part of the ice core. The {sup 36}Cl concentration is well correlated with {delta}{sup 18}O, which is considered as a proxy for paleotemperatures. Assuming that the deposition rate of radionuclides is independent of {delta}{sup 18}O, {sup 36}Cl is used to estimate the relationship between accumulation and {delta}{sup 18}O. The results confirm that the rapid changes of {delta}{sup 18}O, the so-called Dansgaard-Oeschger events, are also reflected in the precipitation rate. (author) 1 fig., 3 refs.

  8. Consistently dated records from the Greenland GRIP, GISP2 and NGRIP ice cores for the past 104 ka reveal regional millennial-scale δ18O gradients with possible Heinrich event imprint

    DEFF Research Database (Denmark)

    Seierstad, Inger Kathrine; Abbott, Peter M.; Bigler, Matthias

    2014-01-01

    NGRIP, GRIP, and GISP2 are generally very similar and display synchronous behaviour at climate transitions. The δ18O differences between Summit and NGRIP, however, changed slowly over the Last Glacial–Interglacial cycle and also underwent abrupt millennial-to-centennial-scale variations. We suggest...

  9. Gait Speed and Grip Strength Reflect Cognitive Impairment and Are Modestly Related to Incident Cognitive Decline in Memory Clinic Patients With Subjective Cognitive Decline and Mild Cognitive Impairment: Findings From the 4C Study

    NARCIS (Netherlands)

    Hooghiemstra, A.M.; Ramakers, I.; Sistermans, N.; Pijnenburg, Y.A.; Aalten, P.; Hamel, R.E.; Melis, R.J.F.; Verhey, F.R.J.; Olde Rikkert, M.G.M.; Scheltens, P.; Flier, W.M. van der

    2017-01-01

    Background: Prospective studies in the general population show that slow gait speed is associated with cognitive decline and clinical progression to dementia. However, longitudinal studies in memory clinic populations are mostly lacking. We aimed to study the association between gait speed and grip

  10. Long-term outcome of muscle strength in ulnar and median nerve injury: Comparing manual muscle strength testing, grip and pinch strength dynamometers and a new intrinsic muscle strength dynamometer

    NARCIS (Netherlands)

    A.R. Schreuders (Ton); M.E. Roebroeck (Marij); J.B. Jaquet (Jean); S.E.R. Hovius (Steven); H.J. Stam (Henk)

    2004-01-01

    textabstractObjective: To compare the outcome of muscle strength with manual muscle strength testing grip and pinch strength measurements and a dynamometer which allows for measurements of the intrinsic muscles of the hand in isolation (the Rotterdam Intrinsic Hand Myometer, RIHM). Methods:

  11. Long-term outcome of muscle strength in ulnar and median nerve injury: Comparing manual muscle strength testing, grip and pinch strength dynamometers and a new intrinsic muscle strength dynamometer

    NARCIS (Netherlands)

    A.R. Schreuders (Ton); M.E. Roebroeck (Marij); J.B. Jaquet (Jean); S.E.R. Hovius (Steven); H.J. Stam (Henk)

    2004-01-01

    textabstractObjective: To compare the outcome of muscle strength with manual muscle strength testing grip and pinch strength measurements and a dynamometer which allows for measurements of the intrinsic muscles of the hand in isolation (the Rotterdam Intrinsic Hand Myometer, RIHM). Methods: Thirty-f

  12. Consistently dated records from the Greenland GRIP, GISP2 and NGRIP ice cores for the past 104 ka reveal regional millennial-scale δ18O gradients with possible Heinrich event imprint

    DEFF Research Database (Denmark)

    Seierstad, Inger Kathrine; Abbott, Peter M.; Bigler, Matthias

    2014-01-01

    NGRIP, GRIP, and GISP2 are generally very similar and display synchronous behaviour at climate transitions. The δ18O differences between Summit and NGRIP, however, changed slowly over the Last Glacial–Interglacial cycle and also underwent abrupt millennial-to-centennial-scale variations. We suggest...

  13. Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice.

    Science.gov (United States)

    Girgis, Christian M; Cha, Kuan Minn; Houweling, Peter J; Rao, Renuka; Mokbel, Nancy; Lin, Mike; Clifton-Bligh, Roderick J; Gunton, Jenny E

    2015-12-01

    Vitamin D deficiency is associated with muscle weakness, pain, and atrophy. Serum vitamin D predicts muscle strength and age-related muscle changes. However, precise mechanisms by which vitamin D affects skeletal muscle are unclear. To address this question, this study characterizes the muscle phenotype and gene expression of mice with deletion of vitamin D receptor (VDRKO) or diet-induced vitamin D deficiency. VDRKO and vitamin D-deficient mice had significantly weaker grip strength than their controls. Weakness progressed with age and duration of vitamin D deficiency, respectively. Histological assessment showed that VDRKO mice had muscle fibers that were significantly smaller in size and displayed hyper-nuclearity. Real-time PCR also indicated muscle developmental changes in VDRKO mice with dysregulation of myogenic regulatory factors (MRFs) and increased myostatin in quadriceps muscle (>2-fold). Vitamin D-deficient mice also showed increases in myostatin and the atrophy marker E3-ubiqutin ligase MuRF1. As a potential explanation for grip strength weakness, both groups of mice had down-regulation of genes encoding calcium-handling and sarco-endoplasmic reticulum calcium transport ATPase (Serca) channels. This is the first report of reduced strength, morphological, and gene expression changes in VDRKO and vitamin D-deficient mice where confounding by calcium, magnesium, and phosphate have been excluded by direct testing. Although suggested in earlier in vitro work, this study is the first to report an in vivo association between vitamin D, myostatin, and the regulation of muscle mass. These findings support a direct role for vitamin D in muscle function and corroborate earlier work on the presence of VDR in this tissue.

  14. Slippage Detection in Gripping Fruits and Vegetables for Agricultural Robot%农业机器人果蔬抓取中滑觉检测研究

    Institute of Scientific and Technical Information of China (English)

    周俊; 朱树平

    2013-01-01

    A kind of sensitive slippage sensor was developed by using piezoresistor, and a slippage observation system was constructed. The technique of STFT was applied to analyze the spectral information of slippage signal. Then slippage signal was distinguished with the signal resulted from different normal griping forces by using the result of DWT. The experimental results showed that the slippage signal was able to be effectively extracted regardless of different normal gripping force. At last, the experiment of gripping force adjustment was carried out by using two parallel fingers hand equipped with the designed slippage sensor. The experimental results of grasping actual fruits and vegetables demonstrated the promise of this slippage sensor in the agricultural picking robot.%利用压敏电阻作为敏感材料制作了一种灵敏的滑觉传感器,构建了滑觉信号观测系统.用短时傅里叶变换方法分析了滑觉信号的频谱特征,并运用离散小波变换结果来区分法向抓取力变化与实际发生的滑动信号,以使滑动信号检测结果不受法向抓取力变化的影响,试验结果表明滑觉检测的稳定性.运用二指平行手爪进行了实际的果蔬抓取试验,验证了基于滑觉检测的抓取力调节效果.

  15. 可调式握力高枝剪设计及分析%Design and Analysis for Grip Type and Adjustable Lopper

    Institute of Scientific and Technical Information of China (English)

    钱稷; 邸葆; 王鹏飞; 陈海江

    2015-01-01

    可调式握力高枝剪的设计包括外观参数的确定和刀具的设计。根据大宗果树的生长状况确定高枝剪各关键部件结构及参数;根据高枝剪在果园作业受到剪枝过程中刀具剪断和夹持枝条所需力的大小进行刀具的设计。通过在Inventor 软件中构建可调式手握高枝剪三维模型,利用 AIP 中的有限元功能对模型进行分析,得出果园工作环境下高枝剪的安全系数和变形量。果园作业试验结果表明:在该设计参数下,高枝剪性能可靠、使用灵活。%According to the orchard pruning , picking jobs in the working environment conditions ( such as cutting and clamping force required for branches , and so on ) and growth of fruit trees ( such as line spacing and height of fruit trees , and so on ) , choose the right material and appearance of the tree pruner parameters .Building three -dimensional model of grip type and adjustable lopper in software of Inventor .Using technology of ANSYS in the AIP for finite element analy-sis of cutter belong to grip type and adjustable lopper , getting safety coefficients of the lopper .Having experiments in or-chards and testing the date .Proved that the lopper in this design parameter is reliable and flexible in use .

  16. Hurricane Imaging Radiometer (HIRAD) Observations of Brightness Temperatures and Ocean Surface Wind Speed and Rain Rate During NASA's GRIP and HS3 Campaigns

    Science.gov (United States)

    Miller, Timothy L.; James, M. W.; Roberts, J. B.; Jones, W. L.; Biswas, S.; Ruf, C. S.; Uhlhorn, E. W.; Atlas, R.; Black, P.; Albers, C.

    2012-01-01

    HIRAD flew on high-altitude aircraft over Earl and Karl during NASA s GRIP (Genesis and Rapid Intensification Processes) campaign in August - September of 2010, and plans to fly over Atlantic tropical cyclones in September of 2012 as part of the Hurricane and Severe Storm Sentinel (HS3) mission. HIRAD is a new C-band radiometer using a synthetic thinned array radiometer (STAR) technology to obtain spatial resolution of approximately 2 km, out to roughly 30 km each side of nadir. By obtaining measurements of emissions at 4, 5, 6, and 6.6 GHz, observations of ocean surface wind speed and rain rate can be retrieved. The physical retrieval technique has been used for many years by precursor instruments, including the Stepped Frequency Microwave Radiometer (SFMR), which has been flying on the NOAA and USAF hurricane reconnaissance aircraft for several years to obtain observations within a single footprint at nadir angle. Results from the flights during the GRIP and HS3 campaigns will be shown, including images of brightness temperatures, wind speed, and rain rate. Comparisons will be made with observations from other instruments on the campaigns, for which HIRAD observations are either directly comparable or are complementary. Features such as storm eye and eye-wall, location of storm wind and rain maxima, and indications of dynamical features such as the merging of a weaker outer wind/rain maximum with the main vortex may be seen in the data. Potential impacts on operational ocean surface wind analyses and on numerical weather forecasts will also be discussed.

  17. Tool Changer For Robot

    Science.gov (United States)

    Voellmer, George M.

    1992-01-01

    Mechanism enables robot to change tools on end of arm. Actuated by motion of robot: requires no additional electrical or pneumatic energy to make or break connection between tool and wrist at end of arm. Includes three basic subassemblies: wrist interface plate attached to robot arm at wrist, tool interface plate attached to tool, and holster. Separate tool interface plate and holster provided for each tool robot uses.

  18. Route Availabililty Planning Tool -

    Data.gov (United States)

    Department of Transportation — The Route Availability Planning Tool (RAPT) is a weather-assimilated decision support tool (DST) that supports the development and execution of departure management...

  19. Novel Robotic Tools for Piping Inspection and Repair, Phase 1

    Science.gov (United States)

    2014-02-13

    11 Basic automated motion using software ... mockup horizontally and vertically. Gripping force testing Pulling in an axial direction the gripper assembly achieved 36.33lbs of gripping force...bags being partially inflated (Figure 11). Figure 11 - Gripper sleds Basic automated motion using software The robot successfully ran on auto

  20. The Takei Handheld Dynamometer: An Effective Clinical Outcome Measure Tool for Hand and Wrist Function in Boxing.

    Science.gov (United States)

    Gatt, Ian; Smith-Moore, Sophie; Steggles, Charlie; Loosemore, Mike

    2017-05-01

    The aim of this article was to explore retrospectively the Takei dynamometer as a valid and reliable outcome measure tool for hand and wrist pathology in the Great Britain amateur boxing squad between 2010 and 2014. Longitudinal retrospective injury surveillance of the Great Britain boxing squad was performed from 2010 to 2014. The location, region affected, description, and duration of each injury were recorded by the team doctor and team physiotherapists. For each significant injury, we recorded hand grip scores using the Takei handheld dynamometer and compared the scores with baseline measures. At the hand, fractures and dislocations were highly detected with an average difference of 40.2% ( P 20% should be highly considered for significant pathology. The Takei dynamometer is a valid and reliable outcome measure tool for hand and wrist pathologies in boxing. Our study highlights the importance of appropriate clinical tools to guide injury management in this sport.

  1. Useful design tools?

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole

    2005-01-01

    Tools for design management are on the agenda in building projects in order to set targets, to choose and prioritise between alternative environmental solutions, to involve stakeholders and to document, evaluate and benchmark. Different types of tools are available, but what can we learn from...... the use or lack of use of current tools in the development of future design tools for sustainable buildings? Why are some used while others are not? Who is using them? The paper deals with design management, with special focus on sustainable building in Denmark, and the challenge of turning the generally...... vague and contested concept of sustainability into concrete concepts and building projects. It describes a typology of tools: process tools, impact assessment tools, multi-criteria tools and tools for monitoring. It includes a Danish paradigmatic case study of stakeholder participation in the planning...

  2. LensTools: Weak Lensing computing tools

    Science.gov (United States)

    Petri, A.

    2016-02-01

    LensTools implements a wide range of routines frequently used in Weak Gravitational Lensing, including tools for image analysis, statistical processing and numerical theory predictions. The package offers many useful features, including complete flexibility and easy customization of input/output formats; efficient measurements of power spectrum, PDF, Minkowski functionals and peak counts of convergence maps; survey masks; artificial noise generation engines; easy to compute parameter statistical inferences; ray tracing simulations; and many others. It requires standard numpy and scipy, and depending on tools used, may require Astropy (ascl:1304.002), emcee (ascl:1303.002), matplotlib, and mpi4py.

  3. Slip of grip of a molecular motor on a crowded track: Modeling shift of reading frame of ribosome on RNA template

    Science.gov (United States)

    Mishra, Bhavya; Schütz, Gunter M.; Chowdhury, Debashish

    2016-06-01

    We develop a stochastic model for the programmed frameshift of ribosomes synthesizing a protein while moving along a mRNA template. Normally the reading frame of a ribosome decodes successive triplets of nucleotides on the mRNA in a step-by-step manner. We focus on the programmed shift of the ribosomal reading frame, forward or backward, by only one nucleotide which results in a fusion protein; it occurs when a ribosome temporarily loses its grip to its mRNA track. Special “slippery” sequences of nucleotides and also downstream secondary structures of the mRNA strand are believed to play key roles in programmed frameshift. Here we explore the role of an hitherto neglected parameter in regulating -1 programmed frameshift. Specifically, we demonstrate that the frameshift frequency can be strongly regulated also by the density of the ribosomes, all of which are engaged in simultaneous translation of the same mRNA, at and around the slippery sequence. Monte Carlo simulations support the analytical predictions obtained from a mean-field analysis of the stochastic dynamics.

  4. Hook-up of GluA2, GRIP and liprin-α for cholinergic muscarinic receptor-dependent LTD in the hippocampus

    Directory of Open Access Journals (Sweden)

    Wu Long-Jun

    2009-06-01

    Full Text Available Abstract The molecular mechanism underlying muscarinic acetylcholine receptor-dependent LTD (mAChR-LTD in the hippocampus is less studied. In a recent study, a novel mechanism is described. The induction of mAChR-LTD required the activation of protein tyrosine phosphatase (PTP, and the expression was mediated by AMPA receptor endocytosis via interactions between GluA2, GRIP and liprin-α. The hook-up of these proteins may result in the recruitment of leukocyte common antigen-related receptor (LAR, a PTP that is known to be involved in AMPA receptor trafficking. Interestingly, the similar molecular interaction cannot be applied to mGluR-LTD, despite the fact that the same G-protein involved in LTD is activated by both mAChR and mGluR. This discovery provides key molecular insights for cholinergic dependent cognitive function, and mAChR-LTD can serve as a useful cellular model for studying the roles of cholinergic mechanism in learning and memory.

  5. UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.

    Science.gov (United States)

    Dato, Serena; Soerensen, Mette; Montesanto, Alberto; Lagani, Vincenzo; Passarino, Giuseppe; Christensen, Kaare; Christiansen, Lene

    2012-08-01

    An efficient uncoupling process is generally considered to have a protective effect on the aging muscle by slowing down its age-related decay. Genetic polymorphisms in the Uncoupling Protein 3 (UCP3) gene, whose product is mainly expressed in skeletal muscle, were suggested to be associated with hand grip (HG) performances in elderly populations. Considering the population specificity of the quality of aging, we aimed to add further support to this evidence by analyzing the association between four SNPs in the UCP3 gene and relative haplotypes in two large cohorts of middle aged (N=708) and oldest old Danes (N=908). We found that the variability at rs1685354 and rs11235972 was associated with HG levels both at single and haplotypic level in both cohorts. Furthermore, taking advantage of large cohort and period survival data of the oldest cohort, we tested the association of each SNP with survival at 10years from the baseline visit. Interestingly, we found that allele A at rs11235972, associated in this cohort with lowest HG scores, influences also the survival patterns, with people carrying this allele showing higher mortality rates. On the whole, our work supports the role of UCP3 gene in functional status and survival at old age.

  6. The Reliability and Validity of Toe Grip Strength as an Index of Physical Development in 4- to 5-Year-Old Children

    Institute of Scientific and Technical Information of China (English)

    Takahiro Ikeda[1; Osamu Aoyagi[2

    2015-01-01

    Studies on TGS (toe-grip strength) are currently proliferating as a result of the development of the dynamometer. The purpose of the present study was to investigate the reliability and validity of TGS as a physical function in preschool aged children. The participants were 153 preschoolers. Each participant was measured in terms of his or her TGS and completed a MAT (motor ability test). The reliability of the measurements was investigated via Pearson's r and Cronbach's a through a test-retest method, as well as a Bland-Altman plot. The validity of the TGS value was investigated by measuring the correlation between TGS and each component of the MAT, the principal component analysis, and a two-way layout ANOVA with general linear model (gender and age). All reliability coefficients were more than 0.70. Though all components of the MAT relating to TGS were found to be significant (P 〈 0.05), these correlations were weak. However, TGS was found to be a physical function that relating to the lower limbs and develops with aging. Therefore, TGS was found to be a highly reliable measure of physical function performance in preschoolers.

  7. COMPARISON OF ACTIVE RELEASE TECHNIQUE AND MYOFASCIAL RELEASE TECHNIQUE ON PAIN, GRIP STRENGTH & FUNCTIONAL PERFORMANCE IN PATIENTS WITH CHRONIC LATERAL EPICONDYLITIS

    Directory of Open Access Journals (Sweden)

    Parth Trivedi

    2014-06-01

    Full Text Available Background & Purpose: Lateral epicondylitis is the most common lesion of the elbow. Tennis elbow or lateral epicondylitis is defined as a syndrome of pain in the wrist extensor muscles at or near their lateral epicondyle origin or pain directly over the lateral epicondyle. So, the aim of this study was to compare the effectiveness of Active Release Technique (ART and Myofascial Release Technique (MFR in the treatment of Chronic Lateral Epicondylitis (CLE. Methodology: The study included thirty-six patients with Chronic Lateral Epicondylitis of age group range between 30 to 45 years. Patients were randomly divided into three groups: Control Group (A, Active Release Technique Group (B and Myofascial Release Technique Group (C. The patients were treated for 4 weeks and three outcome measures: 0-10 NPRS, Hand Dynamometer and PRTEE were taken for assessment and analysis at baseline and after 4th weeks was done. Result: In this study the result showed that Active Release Technique and Myofascial Release Technique were effective in all three outcome measures when compared to Control Group. Myofascial Release Technique was more effective in improving grip strength & reducing pain & disability when compared to Active Release Technique.(p<0.05 Conclusion: Active Release Technique and Myofascial Release Technique are effective in patients with Chronic Lateral Epicondylitis. Myofascial Release Technique demonstrated better outcomes than Active Release Technique in the management of Chronic Lateral Epicondylitis.

  8. Water isotope diffusion rates from the NorthGRIP ice core for the last 16,000 years - glaciological and paleoclimatic implications

    CERN Document Server

    Gkinis, Vasileios; Buchardt, Susanne L; White, James W; Vinther, Bo M

    2014-01-01

    A high resolution (0.05 m) water isotopic record $\\delta^{18}\\mathrm{O}$ is available from the NorthGRIP ice core. In this study we look into the water isotope diffusion history as estimated by the spectral characteristics of the $\\delta^{18}\\mathrm{O}$ time series covering the last 16,000 years. Based on it we infer a temperature history signal for the site. We use a water isotope diffusion model coupled to a steady-state densification model in order to infer the temperature signal from the site, assuming the accumulation and strain rate history as estimated using the GICC05 layer counted chronology and a Dansgaard--Johnsen ice flow model. The necessary corrections regarding ice diffusion and the discretized sampling of the dataset are also described. The temperature reconstruction accurately captures the timing and magnitude of the B{\\o}lling--Aller{\\o}d and Younger Dryas transitions. A Holocene climatic optimum is seen between 7 and 9 ky b2k with an apparent cooling trend thereafter. Our temperature estima...

  9. Imaginary Pasts: Colonisation, Migration and Loss in J.G. Farrell’s 'The Singapore Grip' and in Amitav Ghosh’s 'The Glass Palace'

    Directory of Open Access Journals (Sweden)

    Michael C. Prusse

    2009-11-01

    Full Text Available A quotation from each of the two novels that form the background for this paper will immediately establish why these narratives are pertinent to the central theme of the ‘Moving Cultures, Shifting Identities Conference’ that took place at Flinders University in Adelaide early in December 2007. In both texts the theme of migration in the context of imperialism plays a central role and, moreover, both clearly spell out what tremendous impact moving between and across cultures has on the lives of people, who are thoroughly affected and marked by such encounters. Matthew Webb, one of the protagonists of J.G. Farrell’s The Singapore Grip (1978, renders his perception of the phenomenon of migration in the wake of imperial expansion as follows: ‘One of the most astounding things about our Empire … is the way we’ve transported vast populations across the globe as cheap labour’. Matthew, a critical observer of British imperialism but still a member of colonial society and a British citizen, thus provides the reader with an insight regarding the economic motivation behind such enforced movements of people.

  10. GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse

    Directory of Open Access Journals (Sweden)

    Sylvia Pfennig

    2017-10-01

    Full Text Available Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA receptor trafficking in response to neuronal activity is critical for synaptic function and plasticity. Here, we show that neuronal activity induces the binding of ephrinB2 and ApoER2 receptors at the postsynapse to regulate de novo insertion of AMPA receptors. Mechanistically, the multi-PDZ adaptor glutamate-receptor-interacting protein 1 (GRIP1 binds ApoER2 and bridges a complex including ApoER2, ephrinB2, and AMPA receptors. Phosphorylation of ephrinB2 in a serine residue (Ser-9 is essential for the stability of such a complex. In vivo, a mutation on ephrinB2 Ser-9 in mice results in a complete disruption of the complex, absence of ApoER2 downstream signaling, and impaired activity-induced and ApoER2-mediated AMPA receptor insertion. Using compound genetics, we show the requirement of this complex for long-term potentiation (LTP. Together, our findings uncover a cooperative ephrinB2 and ApoER2 signaling at the synapse, which serves to modulate activity-dependent AMPA receptor dynamic changes during synaptic plasticity.

  11. Studyng the Influence of Aerosols in the Evolution of Cloud Microphysics Procesess Associated with Tropical Cyclone Earl Using Airborne Measurements from the NASA Grip Field Campaing 2010

    Science.gov (United States)

    Luna-Cruz, Y.; Heymsfield, A.; Jenkins, G. S.; Bansemer, A.

    2011-12-01

    Cloud microphysics processes are strongly related to tropical cyclones evolution. Although there have been three decades of research dedicated to understand the role of cloud microphysics in tropical cyclogenesis, there are still questions unanswered. With the intention of fulfill the gaps and to better understand the processes involves in tropical storms formation the NASA Genesis and Rapid Intensification Processes (GRIP) field campaign was conducted during the months of August and September of 2010. In-situ microphysical measurements, including particle size distributions, shapes, liquid/ice water content and supercooled liquid water were obtained from the DC-8 aircraft. A total of 139 hrs of flying science modules were performed including sampling of four named storms (Earl, Gaston, Karl and Matthew). One tropical cyclone, Earl, was one of the major hurricanes of the season reaching a category 4 in the Saffir-Simpson scale. Earl emerged from the West Africa on August 22 as an easterly wave, moved westward and became a tropical storm on August 25 before undergoing rapid intensification. This project seeks to explore the lifecycle of hurricane Earl including the genesis and rapid intensification from a microphysics perspective; to develop a better understanding of the relationship between dust from the Saharan Air Layer and cloud microphysics evolution and to develop a better understanding of how cloud microphysics processes interacts and serve as precursor for thermodynamics processes. An overview of the microphysics measurements as well as preliminary results will be presented.

  12. The influence of respiratory acid-base changes on muscle performance and excitability of the sarcolemma during strenuous intermittent hand grip exercise.

    Science.gov (United States)

    Hilbert, M; Shushakov, V; Maassen, N

    2012-02-01

    Acidification has been reported to provide protective effects on force production in vitro. Thus, in this study, we tested if respiratory acid-base changes influence muscle function and excitability in vivo. Nine subjects performed strenuous, intermittent hand grip exercises (10 cycles of 15 s of work/45 s of rest) under respiratory acidosis by CO(2) rebreathing, alkalosis by hyperventilation, or control. The Pco(2), pH, K(+) concentration ([K(+)]), and Na(+) concentration were measured in venous and arterialized blood. Compound action potentials (M-wave) were elicited to examine the excitability of the sarcolemma. The surface electromyogram (EMG) was recorded to estimate the central drive to the muscle. The lowest venous pH during the exercise period was 7.24 ± 0.03 in controls, 7.31 ± 0.05 with alkalosis, and 7.17 ± 0.04 with acidosis (P acidosis than with alkalosis, and, after the second cycle, it was smaller with acidosis than with the control condition (P Respiratory alkalosis stabilized the M-wave area without influencing performance. Thus, we did not find a direct link between performance and alteration of excitability of the sarcolemma due to changes in pH in vivo.

  13. Slip of grip of a molecular motor on a crowded track: Modeling shift of reading frame of ribosome on RNA template

    CERN Document Server

    Mishra, Bhavya; Chowdhury, Debashish

    2016-01-01

    We develop a stochastic model for the programmed frameshift of ribosomes synthesizing a protein while moving along a mRNA template. Normally the reading frame of a ribosome decodes successive triplets of nucleotides on the mRNA in a step-by-step manner. We focus on the programmed shift of the ribosomal reading frame, forward or backward, by only one nucleotide which results in a fusion protein; it occurs when a ribosome temporarily loses its grip to its mRNA track. Special "slippery" sequences of nucleotides and also downstream secondary structures of the mRNA strand are believed to play key roles in programmed frameshift. Here we explore the role of an hitherto neglected parameter in regulating -1 programmed frameshift. Specifically, we demonstrate that the frameshift frequency can be strongly regulated also by the density of the ribosomes, all of which are engaged in simultaneous translation of the same mRNA, at and around the slippery sequence. Monte Carlo simulations support the analytical predictions obt...

  14. Comparative investigations of manual action representations: evidence that chimpanzees represent the costs of potential future actions involving tools.

    Science.gov (United States)

    Frey, Scott H; Povinelli, Daniel J

    2012-01-12

    The ability to adjust one's ongoing actions in the anticipation of forthcoming task demands is considered as strong evidence for the existence of internal action representations. Studies of action selection in tool use reveal that the behaviours that we choose in the present moment differ depending on what we intend to do next. Further, they point to a specialized role for mechanisms within the human cerebellum and dominant left cerebral hemisphere in representing the likely sensory costs of intended future actions. Recently, the question of whether similar mechanisms exist in other primates has received growing, but still limited, attention. Here, we present data that bear on this issue from a species that is a natural user of tools, our nearest living relative, the chimpanzee. In experiment 1, a subset of chimpanzees showed a non-significant tendency for their grip preferences to be affected by anticipation of the demands associated with bringing a tool's baited end to their mouths. In experiment 2, chimpanzees' initial grip preferences were consistently affected by anticipation of the forthcoming movements in a task that involves using a tool to extract a food reward. The partial discrepancy between the results of these two studies is attributed to the ability to accurately represent differences between the motor costs associated with executing the two response alternatives available within each task. These findings suggest that chimpanzees are capable of accurately representing the costs of intended future actions, and using those predictions to select movements in the present even in the context of externally directed tool use.

  15. Synchronising EDML and NorthGRIP ice cores using d18O of atmospheric oxygen (d18 Oatm) and CH4 measurements over MIS5 (80-123 kyr)

    DEFF Research Database (Denmark)

    Capron, E; Landais, A; Lemieux-Dudon, B

    2010-01-01

    Water isotope records from the EPICA Dronning Maud Land (EDML) and the NorthGRIP ice cores have revealed a one to one coupling between Antarctic Isotope Maxima (AIM) and Greenland Dansgaard-Oeschger (DO) events back to 50 kyr. In order to explore if this north-south coupling is persistent over...... Marine Isotopic Stage 5 (MIS 5). a common timescale must first be constructed. Here, we present new records of delta O-18 of O-2 (delta O-18(atm)) and methane (CH4) measured in the air trapped in ice from the EDML (68-147 kyr) and NorthGRIP (70-123 kyr) ice cores. We demonstrate that, through the period...... of interest, CH4 records alone are not sufficient to construct a common gas timescale between the two cores. Millennial-scale variations of delta O-18(atm) are evidenced over MIS 5 both on the Antarctic and Greenland ice cores and are coupled to CH4 profiles to synchronise the NorthGRIP and EDML records...

  16. Foreign Researches of the Relationship Among Grip Strength, Health and Fitness for Older Adults%老年人握力与健康及体适能关系的国外研究现状

    Institute of Scientific and Technical Information of China (English)

    张春华; 叶长林

    2013-01-01

    The measurement of hand grip strength has gained attention as a simple, non-invasive marker of muscle strength of upper extremities, and more and more researches show that it well suitable for clinical use. This review outlines the prognostic relevance of grip strength in various clinical and epidemiologic settings and describes the relationship between grip strength and fitness for older adults.%握力作为一项简单、无创的上肢肌肉力量测试指标而为人们所关注,越来越多的研究显示握力测试应用于临床也是适合的。这篇文献综述概述了在临床医学和流行病学领域里老年人握力的关联与预测,同时也描述了握力与体适能之间的关系。

  17. Plaster core washout tool

    Science.gov (United States)

    Heisman, R. M.; Keir, A. R.; Teramura, K.

    1977-01-01

    Tool powered by pressurized water or air removes water soluble plaster lining from Kevlar/epoxy duct. Rotating plastic cutterhead with sealed end fitting connects flexible shaft that allows tool to be used with curved ducts.

  18. Virtual tool for bilaterally controlled forceps robot--for minimally invasive surgery.

    Science.gov (United States)

    Abeykoon, A M Harsha S; Ohnishi, Kouhei

    2007-09-01

    Bilateral control enables an operator to be placed away from the working environment. A slave manipulator usually works at a remote site or in a hazardous environment while the master operator senses the environment through the slave manipulator. Bilateral control can be used in surgeries. Usually doctors are very sensitive to the tactile sensation they feel through medical tools. If bilateral control is used in a surgery, ideally the doctor should perceive the sensation of both the body tissue and the reaction force from the specialized tool. Many surgical instruments are essentially similar at the tool tip while showing some structural differences at the gripping end. Therefore, it is advantageous for an expensive tool to be replaced by a virtual tool together with a simple tool. With the virtual tool, the surgeon should be able to perceive the feeling of the actual tool together with the reaction force coming from the body tissue; this may also reduce the time taken for a tool change during the surgery. In this study, above ideas were implemented in a bilaterally controlled forceps robot and experiments were carried out to test the applicability of the concept. Bilateral control is used as the method of tactile feedback. Disturbance observer is used for robust control. Reaction force observer is used in place of a force sensor. Virtual model is used in place of the special tool properties. A virtual spring acting at the end of the forceps, was implemented to a bilateral control system, so that the operator at the master side could perceive the feeling of the spring together with reaction forces from the surgical environment. Operator could feel the vivid sensation of the environment through the master manipulator. The virtual model adds a load to the system. The master and slave responses are slightly different, but the result is good enough for the application. This novel approach could be used in many master-slave applications. 2007 John Wiley & Sons, Ltd.

  19. OOTW COST TOOLS

    Energy Technology Data Exchange (ETDEWEB)

    HARTLEY, D.S.III; PACKARD, S.L.

    1998-09-01

    This document reports the results of a study of cost tools to support the analysis of Operations Other Than War (OOTW). It recommends the continued development of the Department of Defense (DoD) Contingency Operational Support Tool (COST) as the basic cost analysis tool for 00TWS. It also recommends modifications to be included in future versions of COST and the development of an 00TW mission planning tool to supply valid input for costing.

  20. Pro Tools HD

    CERN Document Server

    Camou, Edouard

    2013-01-01

    An easy-to-follow guide for using Pro Tools HD 11 effectively.This book is ideal for anyone who already uses ProTools and wants to learn more, or is new to Pro Tools HD and wants to use it effectively in their own audio workstations.

  1. Scheme Program Documentation Tools

    DEFF Research Database (Denmark)

    Nørmark, Kurt

    2004-01-01

    are separate and intended for different documentation purposes they are related to each other in several ways. Both tools are based on XML languages for tool setup and for documentation authoring. In addition, both tools rely on the LAML framework which---in a systematic way---makes an XML language available...

  2. Software engineering tools.

    Science.gov (United States)

    Wear, L L; Pinkert, J R

    1994-01-01

    We have looked at general descriptions and illustrations of several software development tools, such as tools for prototyping, developing DFDs, testing, and maintenance. Many others are available, and new ones are being developed. However, you have at least seen some examples of powerful CASE tools for systems development.

  3. MOD Tool (Microwave Optics Design Tool)

    Science.gov (United States)

    Katz, Daniel S.; Borgioli, Andrea; Cwik, Tom; Fu, Chuigang; Imbriale, William A.; Jamnejad, Vahraz; Springer, Paul L.

    1999-01-01

    The Jet Propulsion Laboratory (JPL) is currently designing and building a number of instruments that operate in the microwave and millimeter-wave bands. These include MIRO (Microwave Instrument for the Rosetta Orbiter), MLS (Microwave Limb Sounder), and IMAS (Integrated Multispectral Atmospheric Sounder). These instruments must be designed and built to meet key design criteria (e.g., beamwidth, gain, pointing) obtained from the scientific goals for the instrument. These criteria are frequently functions of the operating environment (both thermal and mechanical). To design and build instruments which meet these criteria, it is essential to be able to model the instrument in its environments. Currently, a number of modeling tools exist. Commonly used tools at JPL include: FEMAP (meshing), NASTRAN (structural modeling), TRASYS and SINDA (thermal modeling), MACOS/IMOS (optical modeling), and POPO (physical optics modeling). Each of these tools is used by an analyst, who models the instrument in one discipline. The analyst then provides the results of this modeling to another analyst, who continues the overall modeling in another discipline. There is a large reengineering task in place at JPL to automate and speed-up the structural and thermal modeling disciplines, which does not include MOD Tool. The focus of MOD Tool (and of this paper) is in the fields unique to microwave and millimeter-wave instrument design. These include initial design and analysis of the instrument without thermal or structural loads, the automation of the transfer of this design to a high-end CAD tool, and the analysis of the structurally deformed instrument (due to structural and/or thermal loads). MOD Tool is a distributed tool, with a database of design information residing on a server, physical optics analysis being performed on a variety of supercomputer platforms, and a graphical user interface (GUI) residing on the user's desktop computer. The MOD Tool client is being developed using Tcl

  4. MOD Tool (Microwave Optics Design Tool)

    Science.gov (United States)

    Katz, Daniel S.; Borgioli, Andrea; Cwik, Tom; Fu, Chuigang; Imbriale, William A.; Jamnejad, Vahraz; Springer, Paul L.

    1999-01-01

    The Jet Propulsion Laboratory (JPL) is currently designing and building a number of instruments that operate in the microwave and millimeter-wave bands. These include MIRO (Microwave Instrument for the Rosetta Orbiter), MLS (Microwave Limb Sounder), and IMAS (Integrated Multispectral Atmospheric Sounder). These instruments must be designed and built to meet key design criteria (e.g., beamwidth, gain, pointing) obtained from the scientific goals for the instrument. These criteria are frequently functions of the operating environment (both thermal and mechanical). To design and build instruments which meet these criteria, it is essential to be able to model the instrument in its environments. Currently, a number of modeling tools exist. Commonly used tools at JPL include: FEMAP (meshing), NASTRAN (structural modeling), TRASYS and SINDA (thermal modeling), MACOS/IMOS (optical modeling), and POPO (physical optics modeling). Each of these tools is used by an analyst, who models the instrument in one discipline. The analyst then provides the results of this modeling to another analyst, who continues the overall modeling in another discipline. There is a large reengineering task in place at JPL to automate and speed-up the structural and thermal modeling disciplines, which does not include MOD Tool. The focus of MOD Tool (and of this paper) is in the fields unique to microwave and millimeter-wave instrument design. These include initial design and analysis of the instrument without thermal or structural loads, the automation of the transfer of this design to a high-end CAD tool, and the analysis of the structurally deformed instrument (due to structural and/or thermal loads). MOD Tool is a distributed tool, with a database of design information residing on a server, physical optics analysis being performed on a variety of supercomputer platforms, and a graphical user interface (GUI) residing on the user's desktop computer. The MOD Tool client is being developed using Tcl

  5. Machine tool structures

    CERN Document Server

    Koenigsberger, F

    1970-01-01

    Machine Tool Structures, Volume 1 deals with fundamental theories and calculation methods for machine tool structures. Experimental investigations into stiffness are discussed, along with the application of the results to the design of machine tool structures. Topics covered range from static and dynamic stiffness to chatter in metal cutting, stability in machine tools, and deformations of machine tool structures. This volume is divided into three sections and opens with a discussion on stiffness specifications and the effect of stiffness on the behavior of the machine under forced vibration c

  6. Scheme Program Documentation Tools

    DEFF Research Database (Denmark)

    Nørmark, Kurt

    2004-01-01

    This paper describes and discusses two different Scheme documentation tools. The first is SchemeDoc, which is intended for documentation of the interfaces of Scheme libraries (APIs). The second is the Scheme Elucidator, which is for internal documentation of Scheme programs. Although the tools...... are separate and intended for different documentation purposes they are related to each other in several ways. Both tools are based on XML languages for tool setup and for documentation authoring. In addition, both tools rely on the LAML framework which---in a systematic way---makes an XML language available...

  7. 基于复合滑移理论的轮胎抓地状态建模与验证%Construction and verification of tire grip state based on combined-slip theory

    Institute of Scientific and Technical Information of China (English)

    李波; 赵又群; 臧利国; 王健; 张明杰

    2014-01-01

    In order to obtain accurate estimation of the tire gripping state, a model on the interaction between the tire and the ground playing a key role in the driving stability and the security of vehicles was studied in this paper. Adopting the Brush Model of tire and considering the contact differences between the longitudinal slip and the lateral slip considered, an improved Brush Model of tire based on the compound slip theory was proposed for modeling the tire gripping state. The Brush Model is an important method to predict the force between the tire and the ground, and in this simplified tire model, the contact state between the tire and the road can be divided into the adhesion area and the slip area. The forces in the adhesion area come from the static friction between the tread of rigid carcass and the road, and the forces in the slip area come from the sliding friction between the tread and the road. The innovation of this article is to distinguish the friction types between the adhesion section and the slip section, and the friction coefficients between the longitudinal and the lateral. The tire’s ability to grip is the critical factor of driving, braking, steering and other performances of the vehicle, which comes from the horizontal friction between the tire and the ground. Various active control technologies have been developed to improve the drivability and applied to the active safety system of commercial vehicles. Some experts have raised the protection function of the limit manipulation cases, which was applied into the active manipulation controller. The ratio of the horizontal force and the vertical force was defined as the adhesion coefficient to analyze vehicle adhesion state in some papers. However, it only reflected the change of tire gripping, but the sliding state (the dangerous degree of tire slipping) could not be predicted due to the less accurate model or the complex parameter structure. The state of tire gripping was determined by the

  8. Enterprise integration: A tool`s perspective

    Energy Technology Data Exchange (ETDEWEB)

    Polito, J. [Sandia National Labs., Albuquerque, NM (United States); Jones, A. [National Inst. of Standards and Technology, Gaithersburg, MD (United States); Grant, H. [National Science Foundation, Washington, DC (United States)

    1993-06-01

    The advent of sophisticated automation equipment and computer hardware and software is changing the way manufacturing is carried out. To compete in the global marketplace, manufacturing companies must integrate these new technologies into their factories. In addition, they must integrate the planning, control, and data management methodologies needed to make effective use of these technologies. This paper provides an overview of recent approaches to achieving this enterprise integration. It then describes, using simulation as a particular example, a new tool`s perspective of enterprise integration.

  9. Four Weeks of finger grip training increases the rate of force development and the maximal force in elite and world-top ranking climbers.

    Science.gov (United States)

    Levernier, Guillaume; Laffaye, Guillaume

    2017-09-19

    The goal of this study was to assess the impact of a specific four-week training program on finger grip in climbers; specifically, on the maximal force and the rate of force development (RFD) of finger muscles in isometric contraction. The participants were 14 French male rock climbers who took part in national and international bouldering competitions (at world-ranking and elite levels). They were divided into two samples. The experimental group performed a specific four-week training program that included such exercises as suspensions on small holds at the rate of three times a week. The control group performed climbing exercises only. The maximal force and the RFD were recorded using a specific dynamometer in three different holding conditions (slope crimp, half crimp and full crimp). Results reveal a significant gain of force for the slope crimp (+ 8 %) and a high increase of the RFD in the first 200ms of the force-time slope (between 27.5 % and 32 % for averaged conditions), suggesting a neural gain rather a change in muscle-tendon structure. These results reveals that a four-week training program is enough to improve the level of maximum force and rate of force development in elite climbers. Bearing in mind that climbing will make its appearance in a future Olympic Games in the form of a combined competition, i.e., bouldering, speed climbing and lead climbing, it will be crucial for each athlete to develop both a high level of force and RFD to be competitive.

  10. New insights on the anatomy of abrupt climate changes based on high-resolution ice core records from NorthGRIP (Greenland)

    Science.gov (United States)

    Capron, E.; Rasmussen, S.; Popp, T. J.; Vaughn, B. H.; Gkinis, V.; Erhardt, T.; Fischer, H.; Blunier, T.; Landais, A.; Pedro, J. B.; Steffensen, J. P.; Svensson, A.; Vinther, B.

    2016-12-01

    The millennial-scale succession of Greenland Stadials (GS) and Greenland Interstadials (GI) illustrates the Greenland expression of the well-known sequence of Dansgaard-Oeschger (DO) events, within which we observe additional climate variations of decadal to centennial-scale duration. Various paradigms, mostly based on interactions between the cryosphere and the ocean, have been proposed to explain the existence and evolution of DO events. Annual to decadal scale records of environmental and climatic regional changes over the rapid transitions are needed to assess whether climate model outputs based on a particular mechanism are consistent with the observed spatial pattern and temporal phasing. Here we present new multiannual resolution stable water isotope measurements (ice δ18O and δD) and annually resolved ion chemistry records from the NorthGRIP ice core. Because these tracers imprint the signatures of different parts of the Northern Hemisphere climate system, we can map the anatomy - the spatial and temporal signature of climate and environmental changes - associated with abrupt transitions (from GS to GI and vice-versa) occurring during Marine Isotopic Stage (MIS) 4. We determine via a statistical approach the timing and duration of the transitions, along with the amplitude of the local and regional changes associated with each Greenland warming and cooling phase. We quantify similarities and differences in the sequences of events through a comparison with results obtained for MIS 3 abrupt transitions and results from the NEEM ice core for selected transitions. The anatomy of abrupt climate changes appears to be different from one event to the next, suggesting that the mechanisms at play are not identical for all of them. We discuss the possible influence of (1) the Heinrich Stadials (i.e. GS during which a Heinrich Event occurred) and of (2) the long term evolution of the climate system on the different decadal to centennial-scale sequences of events

  11. Water isotope diffusion rates from the NorthGRIP ice core for the last 16,000 years - Glaciological and paleoclimatic implications

    Science.gov (United States)

    Gkinis, V.; Simonsen, S. B.; Buchardt, S. L.; White, J. W. C.; Vinther, B. M.

    2014-11-01

    A high resolution (0.05 m) water isotopic record (δO18) is available from the NorthGRIP ice core. In this study we look into the water isotope diffusion history as estimated by the spectral characteristics of the δO18 time series covering the last 16,000 years. The diffusion of water vapor in the porous medium of the firn pack attenuates the initial isotopic signal, predominantly having an impact on the high frequency components of the power spectrum. Higher temperatures induce higher rates of smoothing and thus the signal can be used as a firn paleothermometer. We use a water isotope diffusion model coupled to a steady-state densification model in order to infer the temperature signal from the site, assuming the accumulation and strain rate history as estimated using the GICC05 layer counted chronology and a Dansgaard-Johnsen ice flow model. The temperature reconstruction accurately captures the timing and magnitude of the Bølling-Allerød and Younger Dryas transitions. A Holocene climatic optimum is seen between 7 and 9 ky b2k with an apparent cooling trend thereafter. Our temperature estimate for the Holocene climatic optimum, points to a necessary adjustment of the ice thinning function indicating that the ice flow model overestimates past accumulation rates by about 10% at 8 ky b2k. This result, is supported by recent gas isotopic fractionation studies proposing a similar reduction for glacial conditions. Finally, the record presents a climatic variability over the Holocene spanning millennial and centennial scales with a profound cooling occurring at approximately 4000 years b2k. The new reconstruction technique is able to provide past temperature estimates by overcoming the issues apparent in the use of the classical δO18 slope method. It can at the same time resolve temperature signals at low and high frequencies.

  12. Lunar hand tools

    Science.gov (United States)

    Bentz, Karl F.; Coleman, Robert D.; Dubnik, Kathy; Marshall, William S.; Mcentee, Amy; Na, Sae H.; Patton, Scott G.; West, Michael C.

    1987-01-01

    Tools useful for operations and maintenance tasks on the lunar surface were determined and designed. Primary constraints are the lunar environment, the astronaut's space suit and the strength limits of the astronaut on the moon. A multipurpose rotary motion tool and a collapsible tool carrier were designed. For the rotary tool, a brushless motor and controls were specified, a material for the housing was chosen, bearings and lubrication were recommended and a planetary reduction gear attachment was designed. The tool carrier was designed primarily for ease of access to the tools and fasteners. A material was selected and structural analysis was performed on the carrier. Recommendations were made about the limitations of human performance and about possible attachments to the torque driver.

  13. P2-37: Processing Affordance Information from Invisible Tool Images

    Directory of Open Access Journals (Sweden)

    Shinho Cho

    2012-10-01

    Full Text Available A recent study showed that viewing manipulable objects such as images of tools induces the neural activation of posterior parietal areas. This neural activation is observed even when visual awareness of the image is visually suppressed. (Fang and He, 2005 Nature Neuroscience 10 1380–1385; Almeida et al, 2010 Psychological Science 21 772–778. However, the specific visuomotor information in tool images that drives the activation of dorsal areas is still unclear. We measured priming effect of invisible tool prime (left or right handed orientation. Observers distinguished the orientation of target tools (appropriate for left vs right handed grip briefly presented following visually suppressed primes (Experiment1. Also we measured the suppression time of tool images whose handle direction was presented in a left- or right-handed orientation. A dynamic noise pattern was presented to one of the observer's eyes at full contrast, while images of tools (left or right handed were simultaneously presented to the left or right visual field of the other eye. The subjects were asked to respond to the appearance of any partial or full part of the test image (Experiment 2. Results showed that (1 observers responded faster in the congruent condition (the same orientation between prime and target and (2 tool images shown in the right visual field took less time to gain dominance against the dynamic noise. These results suggest that even without overt recognition of presented tools, an object's affordance can be registered and processed in the brain. A recent study showed that viewing manipulable objects such as images of tools induces the neural activation of posterior parietal areas. This neural activation is observed even when visual awareness of the image is visually suppressed (Almeida et al., 2010 Psychological Science 21 772–778; Fang and He, 2005 Nature Neuroscience 10 1380–1385. However, the specific visuomotor information in tool images that

  14. Open Health Tools: Tooling for Interoperable Healthcare

    Directory of Open Access Journals (Sweden)

    Skip McGaughey

    2008-11-01

    Full Text Available The Open Health Tools initiative is creating an ecosystem focused on the production of software tooling that promotes the exchange of medical information across political, geographic, cultural, product, and technology lines. At its core, OHT believes that the availability of high-quality tooling that interoperates will propel the industry forward, enabling organizations and vendors to build products and systems that effectively work together. This will ?raise the interoperability bar? as a result of having tools that just work. To achieve these lofty goals, careful consideration must be made to the constituencies that will be most affected by an OHT-influenced world. This document outlines a vision of OHT?s impact to these stakeholders. It does not explain the OHT process itself or how the OHT community operates. Instead, we place emphasis on the impact of that process within the health industry. The catchphrase ?code is king? underpins this document, meaning that the manifestation of any open source community lies in the products and technology it produces.

  15. Authoring tool evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, A.L.; Klenk, K.S.; Coday, A.C.; McGee, J.P.; Rivenburgh, R.R.; Gonzales, D.M.; Mniszewski, S.M.

    1994-09-15

    This paper discusses and evaluates a number of authoring tools currently on the market. The tools evaluated are Visix Galaxy, NeuronData Open Interface Elements, Sybase Gain Momentum, XVT Power++, Aimtech IconAuthor, Liant C++/Views, and Inmark Technology zApp. Also discussed is the LIST project and how this evaluation is being used to fit an authoring tool to the project.

  16. Population Density Modeling Tool

    Science.gov (United States)

    2014-02-05

    194 POPULATION DENSITY MODELING TOOL by Davy Andrew Michael Knott David Burke 26 June 2012 Distribution...MARYLAND NAWCADPAX/TR-2012/194 26 June 2012 POPULATION DENSITY MODELING TOOL by Davy Andrew Michael Knott David Burke...Density Modeling Tool 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Davy Andrew Michael Knott David Burke 5d. PROJECT NUMBER

  17. CMS offline web tools

    CERN Document Server

    Metson, S; Bockelman, B; Dziedziniewicz, K; Egeland, R; Elmer, P; Eulisse, G; Evans, D; Fanfani, A; Feichtinger, D; Kavka, C; Kuznetsov, V; Van Lingen, F; Newbold, D; Tuura, L; Wakefield, S

    2008-01-01

    We describe a relatively new effort within CMS to converge on a set of web based tools, using state of the art industry techniques, to engage with the CMS offline computing system. CMS collaborators require tools to monitor various components of the computing system and interact with the system itself. The current state of the various CMS web tools is described along side current planned developments.

  18. Agreement Workflow Tool (AWT)

    Data.gov (United States)

    Social Security Administration — The Agreement Workflow Tool (AWT) is a role-based Intranet application used for processing SSA's Reimbursable Agreements according to SSA's standards. AWT provides...

  19. Java Power Tools

    CERN Document Server

    Smart, John

    2008-01-01

    All true craftsmen need the best tools to do their finest work, and programmers are no different. Java Power Tools delivers 30 open source tools designed to improve the development practices of Java developers in any size team or organization. Each chapter includes a series of short articles about one particular tool -- whether it's for build systems, version control, or other aspects of the development process -- giving you the equivalent of 30 short reference books in one package. No matter which development method your team chooses, whether it's Agile, RUP, XP, SCRUM, or one of many other

  20. Qlikview Audit Tool (QLIKVIEW) -

    Data.gov (United States)

    Department of Transportation — This tool supports the cyclical financial audit process. Qlikview supports large volumes of financial transaction data that can be mined, summarized and presented to...

  1. Double diameter boring tool

    Science.gov (United States)

    Ashbaugh, Fred N.; Murry, Kenneth R.

    1988-12-27

    A boring tool and a method of operation are provided for boring two concentric holes of precision diameters and depths in a single operation. The boring tool includes an elongated tool body, a shank for attachment to a standard adjustable boring head which is used on a manual or numerical control milling machine and first and second diametrically opposed cutting edges formed for cutting in opposite directions. The diameter of the elongated tool body is substantially equal to the distance from the first cutting edge tip to the axis of rotation plus the distance from the second cutting edge tip to the axis of rotation. The axis of rotation of the tool is spaced from the tool centerline a distance substantially equal to one-half the distance from the second cutting edge tip to the axis of rotation minus one-half the distance from the first cutting edge tip to the axis of rotation. The method includes the step of inserting the boring tool into the boring head, adjusting the distance between the tool centerline and the tool axis of rotation as described above and boring the two concentric holes.

  2. Instant Spring Tool Suite

    CERN Document Server

    Chiang, Geoff

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. A tutorial guide that walks you through how to use the features of Spring Tool Suite using well defined sections for the different parts of Spring.Instant Spring Tool Suite is for novice to intermediate Java developers looking to get a head-start in enterprise application development using Spring Tool Suite and the Spring framework. If you are looking for a guide for effective application development using Spring Tool Suite, then this book is for you.

  3. Pneumatically actuated hand tool

    NARCIS (Netherlands)

    Cool, J.C.; Rijnsaardt, K.A.

    1996-01-01

    Abstract of NL 9401195 (A) Pneumatically actuated hand tool for carrying out a mechanical operation, provided with an exchangeable gas cartridge in which the gas which is required for pneumatic actuation is stored. More particularly, the hand tool is provided with at least one pneumatic motor, at

  4. Coring Sample Acquisition Tool

    Science.gov (United States)

    Haddad, Nicolas E.; Murray, Saben D.; Walkemeyer, Phillip E.; Badescu, Mircea; Sherrit, Stewart; Bao, Xiaoqi; Kriechbaum, Kristopher L.; Richardson, Megan; Klein, Kerry J.

    2012-01-01

    A sample acquisition tool (SAT) has been developed that can be used autonomously to sample drill and capture rock cores. The tool is designed to accommodate core transfer using a sample tube to the IMSAH (integrated Mars sample acquisition and handling) SHEC (sample handling, encapsulation, and containerization) without ever touching the pristine core sample in the transfer process.

  5. WATERS Expert Query Tool

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Expert Query Tool is a web-based reporting tool using the EPA’s WATERS database.There are just three steps to using Expert Query:1. View Selection – Choose what...

  6. Study of Tools Interoperability

    NARCIS (Netherlands)

    Krilavičius, T.

    2007-01-01

    Interoperability of tools usually refers to a combination of methods and techniques that address the problem of making a collection of tools to work together. In this study we survey different notions that are used in this context: interoperability, interaction and integration. We point out relation

  7. Maailma suurim tool

    Index Scriptorium Estoniae

    2000-01-01

    AS Tartu näitused, Tartu Kunstikool ja ajakiri 'Diivan' korraldavad 9.-11. III Tartu messikeskuse I paviljonis näituse 'Tool 2000'. Eksponeeritakse 2000 tooli, mille hulgast valitakse TOP 12. Messikeskuse territooriumile on kavas püstitada maailma suurim tool. Samal ajal II paviljonis kaksikmess 'Sisustus 2000' ja 'Büroo 2000'.

  8. Language Management Tools

    DEFF Research Database (Denmark)

    Sanden, Guro Refsum

    management tools is proposed, differentiating between three categories of tools. Firstly, corporate policies are the deliberate control of issues pertaining to language and communication developed at the managerial level of a firm. Secondly, corporate measures are the planned activities the firm’s leadership......This paper offers a review of existing literature on the topic of language management tools – the means by which language is managed – in multilingual organisations. By drawing on a combination of sociolinguistics and international business and management studies, a new taxonomy of language...... may deploy in order to address the language needs of the organisation. Finally, front-line practices refer to the use of informal, emergent language management tools available to staff members. The language management tools taxonomy provides a framework for operationalising the management of language...

  9. Software Tool Issues

    Science.gov (United States)

    Hennell, Michael

    This chapter relies on experience with tool development gained over the last thirty years. It shows that there are a large number of techniques that contribute to any successful project, and that formality is always the key: a modern software test tool is based on a firm mathematical foundation. After a brief introduction, Section 2 recalls and extends the terminology of Chapter 1. Section 3 discusses the the design of different sorts of static and dynamic analysis tools. Nine important issues to be taken into consideration when evaluating such tools are presented in Section 4. Section 5 investigates the interplay between testing and proof. In Section 6, we call for developers to take their own medicine and verify their tools. Finally, we conclude in Section 7 with a summary of our main messages, emphasising the important role of testing.

  10. OOTW Force Design Tools

    Energy Technology Data Exchange (ETDEWEB)

    Bell, R.E.; Hartley, D.S.III; Packard, S.L.

    1999-05-01

    This report documents refined requirements for tools to aid the process of force design in Operations Other Than War (OOTWs). It recommends actions for the creation of one tool and work on other tools relating to mission planning. It also identifies the governmental agencies and commands with interests in each tool, from whom should come the user advisory groups overseeing the respective tool development activities. The understanding of OOTWs and their analytical support requirements has matured to the point where action can be taken in three areas: force design, collaborative analysis, and impact analysis. While the nature of the action and the length of time before complete results can be expected depends on the area, in each case the action should begin immediately. Force design for OOTWs is not a technically difficult process. Like force design for combat operations, it is a process of matching the capabilities of forces against the specified and implied tasks of the operation, considering the constraints of logistics, transport and force availabilities. However, there is a critical difference that restricts the usefulness of combat force design tools for OOTWs: the combat tools are built to infer non-combat capability requirements from combat capability requirements and cannot reverse the direction of the inference, as is required for OOTWs. Recently, OOTWs have played a larger role in force assessment, system effectiveness and tradeoff analysis, and concept and doctrine development and analysis. In the first Quadrennial Defense Review (QDR), each of the Services created its own OOTW force design tool. Unfortunately, the tools address different parts of the problem and do not coordinate the use of competing capabilities. These tools satisfied the immediate requirements of the QDR, but do not provide a long-term cost-effective solution.

  11. 一种新的大鼠灌胃方法——侧抓灌胃法%A New Rat Catching and Stomach Gavage Method——Side Grip Gavage Method

    Institute of Scientific and Technical Information of China (English)

    姜骊; 陈辉; 何勇

    2011-01-01

    目的 建立一种新的大鼠抓握和灌胃方法.方法 建立新的大鼠侧抓灌胃方法,达到了操作更简便易行的目的.150只大鼠,分为6组,做中间生物标记物(intermediate biomarkers)研究,每只大鼠每天灌胃1次,持续6个月.结果 所有动物存活良好,顺利完成实验.讨论 新的大鼠侧抓方法改变了大鼠本能性自卫防御的条件反射,在灌胃时能够更好地固定大鼠,更适合对大批量的大鼠进行无损伤、长期安全有效的灌胃.%Objective To set up a new rat grip and stomach gavage method. Methods Establishing a new rat side grip and stomach gavage method , Result 150 rats do intermediate biomarkers study, each rat stomach gavage one time every day, and lasts for six months. Till the end all rats live well, and finish the experiment favorable. Conclusions New rat side grip and stomach gavage method changed the rat self-defense conditioned reflex, through better fixation of the rat, which facilitates the application of the stomach gavage method for a large number of rats and makes it more safe , and decreases the incidence of rat injury especially for long term experiments.

  12. Get a grip on physics

    CERN Document Server

    Gribbin, John

    2011-01-01

    What do Newton's falling apple and the moon's orbit have in common? How does relativity theory apply to everyday life, what's a quantum leap, and why is Schrödinger's cat inside that box? The answers lie within your grasp! John Gribbin, a physicist and author of bestselling popular-science books, offers down-to-earth discussions of technical topics. Playful engravings and cartoons illustrate his imaginative accounts of the workings of string theory, black holes, superfluidity, and other cosmic oddities. Readers of all ages will appreciate these memorable explanations of the laws of physics and

  13. Getting to grips with antihydrogen

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    In June 2011, the ALPHA Collaboration announced that they had successfully managed to trap and hold atoms of antimatter for 1000 seconds. Last week they announced that their success in changing the internal state of antihydrogen and made the first ever measurement of its spectrum. The Collaboration is now installing an all-new experimental set-up – ALPHA-2 – and shows no signs of slowing down its investigations into the anti-world.   The ALPHA experiment hall. Newspapers and magazines around the world described the recent ALPHA announcement as the first step towards explaining why antimatter and matter did not cancel each other out in the first instances of creation, that is, why our universe of matter exists. Understanding the behaviour of matter and antimatter can help scientists solve this conundrum. With this in mind, the ALPHA collaboration has begun the study of the antihydrogen spectrum. So far, the Collaboration has been focused on proving that they can alter the ...

  14. Getting to Grips With Inflation

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The 2010 CENTRAL ECONOMIC WORK CONFERENCE that ended on December 12 offered clear reasons for optimism as policymakers announced their intent to focus on managing inflation expectations in 2011. According to a statement released after the annual top-level economic conference,China endorsed replacing the "appropriately loose" monetary policy with a "prudent" one.Such

  15. Efficacy of a half-grip technique using a fine tip LigaSure™, Dolphin Tip Sealer/Divider, on liver dissection in swine model.

    Science.gov (United States)

    Toyama, Yoichi; Yoshida, Seiya; Saito, Ryota; Iwase, Ryota; Haruki, Koichiro; Okui, Norimitsu; Shimada, Jun-ichi; Kitamura, Hiroaki; Matsumoto, Michinori; Yanaga, Katsuhiko

    2015-08-20

    Recently, a lot of energy devices in the surgical field, especially in the liver surgery, have been developed, and a fine tip LigaSure™, Dolphin Tip Sealer/Divider (DT-SD) also has been used frequently to dissect liver parenchyma as well as ultrasonically activated device (USAD). However, the utility of this instrument for liver dissection (LD) is still unknown. Moreover, to reduce bleeding during LD, a half-grip technique (HGT) was contrived. We herein report an experimental study in swine model to evaluate the feasibility and effectiveness of HGT using DT-SD for LD. The swine model experiment was carried out under general anesthesia by veterinarians. LD was performed repeatedly by DT-SD with the HGT (Group A, n = 6), or the conventional clamp-crush technique (CCT) (Group B, n = 6), and by variable mode USAD (Group C, n = 6). The dissection length and depth (cm) as well as bleeding volume (g) were measured carefully, and the dissection area (cm(2)) and speed (cm(2)/min) were calculated precisely. Histological examinations of the dissection surfaces were also executed. Mann-Whitney's U test was used for Statistical analyses with variance at a significance level of 0.05. Among the three groups, the three averages of dissection lengths were unexpectedly equalized to 8.3 cm. The dissection area (cm(2)) was 9.9 ± 5.1 in Group A, 9.8 ± 4.7 in Group B, and 9.9 ± 4.5 in Group C. The mean blood loss during LD was 10.6 ± 14.8 g in Group A, 41.4 ± 39.2 g in Group B, and 34.3 ± 39.2 g in Group C. For Group A, the bleeding rate was the least, 0.9 ± 1.0 g/cm(2), and the average depth of coagulation was the thickest, 1.47 ± 0.29 mm, among the three groups (p dissection speed in Group A (1.3 ± 0.3 cm(2)/min) was slower, than that in Group C (p < 0.05). This report indicates firstly that the HGT using DT-SD bring the least blood loss when compared with CCT or USAD. Although the HGT is feasible and useful for LD, to popularize the HGT, further clinical studies will be

  16. Relation of grip strength, bone mineral density and body mass index in postmenopausal women%绝经后女性握力和体重指数与骨密度的相关研究

    Institute of Scientific and Technical Information of China (English)

    吕波

    2014-01-01

    Objective To study the positive association between hand grip strength and bone mineral density in postmenopausal women.We conducted a screening program for osteoporosis in a large cohort of postmenopausal women to investigate the relation among hand grip strength,other nutritional parameters and bone density.Methods This investigation involved 973 volunteers from March 2012 to March 2013 at Tianjin Hongqiao Hospital.Bone mineral density,hand grip strength measurement,body mass index and T score were analyzed.Results Univariate analysis showed that hand grip strength measurement,body mass index and T score were correlated (Pearson correlation coefficient were 0.201,0.115,P =0.001,0.009) ; age and T score were negatively correlated(Pearson correlation coefficient were-0.358,P =0.001).Incidence of osteoporosis was 19.7% (192/973).Conclusion Both body mass index and handgrip strength are strongly correlated to bone mineral density.%目的 探讨绝经后女性握力和体重指数与骨密度之间的相关性.方法 收集2012年3月至2013年3月在天津市红桥医院检查治疗973名女性志愿者,所有志愿者均接受足跟部骨密度测量(T指数)、握力测试和体重指数测量并进行相关性分析.结果 在单变量分析中,握力和体重指数与T指数相关(Pearson相关系数分别为0.201、0.115,P=0.001、0.009),年龄与T指数呈负相关(Pearson相关系数为-0.358,P=0.001).骨质疏松发病率18.7%(182/973).有骨质疏松和无骨质疏松绝经年龄、握力比较[绝经年龄(48±6)岁比(49±5)岁,P=0.020;握力(23±6)kg比(24±6) kg,P=0.001].结论 体重指数和握力二者均与骨密度密切相关,二者可作为预示骨疾病的关键因子.

  17. Tool Gear: Infrastructure for Building Parallel Programming Tools

    Energy Technology Data Exchange (ETDEWEB)

    May, J M; Gyllenhaal, J

    2002-12-09

    Tool Gear is a software infrastructure for developing performance analysis and other tools. Unlike existing integrated toolkits, which focus on providing a suite of capabilities, Tool Gear is designed to help tool developers create new tools quickly. It combines dynamic instrumentation capabilities with an efficient database and a sophisticated and extensible graphical user interface. This paper describes the design of Tool Gear and presents examples of tools that have been built with it.

  18. Graphitic packing removal tool

    Energy Technology Data Exchange (ETDEWEB)

    Meyers, K.E.; Kolsun, G.J.

    1996-12-31

    Graphitic packing removal tools are described for removal of the seal rings in one piece from valves and pumps. The packing removal tool has a cylindrical base ring the same size as the packing ring with a surface finish, perforations, knurling or threads for adhesion to the seal ring. Elongated leg shanks are mounted axially along the circumferential center. A slit or slits permit insertion around shafts. A removal tool follower stabilizes the upper portion of the legs to allow a spanner wrench to be used for insertion and removal.

  19. Machine Tool Software

    Science.gov (United States)

    1988-01-01

    A NASA-developed software package has played a part in technical education of students who major in Mechanical Engineering Technology at William Rainey Harper College. Professor Hack has been using (APT) Automatically Programmed Tool Software since 1969 in his CAD/CAM Computer Aided Design and Manufacturing curriculum. Professor Hack teaches the use of APT programming languages for control of metal cutting machines. Machine tool instructions are geometry definitions written in APT Language to constitute a "part program." The part program is processed by the machine tool. CAD/CAM students go from writing a program to cutting steel in the course of a semester.

  20. Benchmarking expert system tools

    Science.gov (United States)

    Riley, Gary

    1988-01-01

    As part of its evaluation of new technologies, the Artificial Intelligence Section of the Mission Planning and Analysis Div. at NASA-Johnson has made timing tests of several expert system building tools. Among the production systems tested were Automated Reasoning Tool, several versions of OPS5, and CLIPS (C Language Integrated Production System), an expert system builder developed by the AI section. Also included in the test were a Zetalisp version of the benchmark along with four versions of the benchmark written in Knowledge Engineering Environment, an object oriented, frame based expert system tool. The benchmarks used for testing are studied.

  1. Smart Growth Tools

    Science.gov (United States)

    This page describes a variety of tools useful to federal, state, tribal, regional, and local government staff and elected officials; community leaders; developers; and others interested in smart growth development.

  2. Recovery Action Mapping Tool

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Recovery Action Mapping Tool is a web map that allows users to visually interact with and query actions that were developed to recover species listed under the...

  3. Cash Reconciliation Tool

    Data.gov (United States)

    US Agency for International Development — CART is a cash reconciliation tool that allows users to reconcile Agency cash disbursements with Treasury fund balances; track open unreconciled items; and create an...

  4. Tools and their uses

    CERN Document Server

    1973-01-01

    Teaches names, general uses, and correct operation of all basic hand and power tools, fasteners, and measuring devices you are likely to need. Also, grinding, metal cutting, soldering, and more. 329 illustrations.

  5. Mapping Medicare Disparities Tool

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Office of Minority Health has designed an interactive map, the Mapping Medicare Disparities Tool, to identify areas of disparities between subgroups of...

  6. Friction stir welding tool

    Science.gov (United States)

    Tolle; Charles R. , Clark; Denis E. , Barnes; Timothy A.

    2008-04-15

    A friction stir welding tool is described and which includes a shank portion; a shoulder portion which is releasably engageable with the shank portion; and a pin which is releasably engageable with the shoulder portion.

  7. Chatter and machine tools

    CERN Document Server

    Stone, Brian

    2014-01-01

    Focussing on occurrences of unstable vibrations, or Chatter, in machine tools, this book gives important insights into how to eliminate chatter with associated improvements in product quality, surface finish and tool wear. Covering a wide range of machining processes, including turning, drilling, milling and grinding, the author uses his research expertise and practical knowledge of vibration problems to provide solutions supported by experimental evidence of their effectiveness. In addition, this book contains links to supplementary animation programs that help readers to visualise the ideas detailed in the text. Advancing knowledge in chatter avoidance and suggesting areas for new innovations, Chatter and Machine Tools serves as a handbook for those desiring to achieve significant reductions in noise, longer tool and grinding wheel life and improved product finish.

  8. Game development tool essentials

    CERN Document Server

    Berinstein, Paula; Ardolino, Alessandro; Franco, Simon; Herubel, Adrien; McCutchan, John; Nedelcu, Nicusor; Nitschke, Benjamin; Olmstead, Don; Robinet, Fabrice; Ronchi, Christian; Turkowski, Rita; Walter, Robert; Samour, Gustavo

    2014-01-01

    Offers game developers new techniques for streamlining the critical game tools pipeline. Inspires game developers to share their secrets and improve the productivity of the entire industry. Helps game industry practitioners compete in a hyper-competitive environment.

  9. Clean Energy Finance Tool

    Science.gov (United States)

    This tool is for state and local governments interested in developing a financing program to support energy efficiency and clean energy improvements for large numbers of buildings within their jurisdiction.

  10. Neighborhood Mapping Tool

    Data.gov (United States)

    Department of Housing and Urban Development — This tool assists the public and Choice Neighborhoods applicants to prepare data to submit with their grant application by allowing applicants to draw the exact...

  11. NWRS Survey Prioritization Tool

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A SMART Tool and User's Guide for aiding NWRS Station staff when prioritizing their surveys for an Inventory and Monitoring Plan. This guide describes a process and...

  12. Chemical Data Access Tool

    Data.gov (United States)

    U.S. Environmental Protection Agency — This tool is intended to aid individuals interested in learning more about chemicals that are manufactured or imported into the United States. Health and safety...

  13. Smart tool holder

    Science.gov (United States)

    Day, Robert Dean; Foreman, Larry R.; Hatch, Douglas J.; Meadows, Mark S.

    1998-01-01

    There is provided an apparatus for machining surfaces to accuracies within the nanometer range by use of electrical current flow through the contact of the cutting tool with the workpiece as a feedback signal to control depth of cut.

  14. TENCompetence tool demonstration

    NARCIS (Netherlands)

    Kluijfhout, Eric

    2010-01-01

    Kluijfhout, E. (2009). TENCompetence tool demonstration. Presented at Zorgacademie Parkstad (Health Academy Parkstad), Limburg Leisure Academy, Life Long Learning Limburg and a number of regional educational institutions. May, 18, 2009, Heerlen, The Netherlands: Open University of the Netherlands, T

  15. ATO Resource Tool -

    Data.gov (United States)

    Department of Transportation — Cru-X/ART is a shift management tool designed for?use by operational employees in Air Traffic Facilities.? Cru-X/ART is used for shift scheduling, shift sign in/out,...

  16. Autism Teaching Tool

    CERN Multimedia

    2014-01-01

    CERN pattern recognition technologies transferred to Austistic children learning tool. The state of the art of pattern recognition technology developed at CERN for High Energy Physics are transferred to Computer Vision domain and are used to develop a new

  17. Learning Design Tools

    NARCIS (Netherlands)

    Griffiths, David; Blat, Josep; Garcia, Rocío; Vogten, Hubert; Kwong, KL

    2005-01-01

    Griffiths, D., Blat, J., Garcia, R., Vogten, H. & Kwong, KL. (2005). Learning Design Tools. In: Koper, R. & Tattersall, C., Learning Design: A Handbook on Modelling and Delivering Networked Education and Training (pp. 109-136). Berlin-Heidelberg: Springer Verlag.

  18. Tools used for hand deburring

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, L.K.

    1981-03-01

    This guide is designed to help in quick identification of those tools most commonly used to deburr hand size or smaller parts. Photographs and textual descriptions are used to provide rapid yet detailed information. The data presented include the Bendix Kansas City Division coded tool number, tool description, tool crib in which the tool can be found, the maximum and minimum inventory requirements, the cost of each tool, and the number of the illustration that shows the tool.

  19. VDC Monitoring Tools

    CERN Document Server

    Porat, Itay Gershon

    2017-01-01

    Electron drift velocity is an important parameter for muon path reconstruction capabilities of CMS drift tube chambers. The parameter is monitored independently by six dedicated drift velocity chambers (VDC). This report presents monitoring tools developed to study key VDC parameters such as anode voltage and current, as well as gas source. These graphical tools can be used to learn about VDC operation and performance, and contribute to understanding anode wire aging in the systems.

  20. Manual bamboo cutting tool.

    Science.gov (United States)

    Bezerra, Mariana Pereira; Correia, Walter Franklin Marques; da Costa Campos, Fabio Ferreira

    2012-01-01

    The paper presents the development of a cutting tool guide, specifically for the harvest of bamboo. The development was made based on precepts of eco-design and ergonomics, for prioritizing the physical health of the operator and the maintenance of the environment, as well as meet specific requirements of bamboo. The main goal is to spread the use of bamboo as construction material, handicrafts, among others, from a handy, easy assembly and material available tool.

  1. Stochastic tools in turbulence

    CERN Document Server

    Lumey, John L

    2012-01-01

    Stochastic Tools in Turbulence discusses the available mathematical tools to describe stochastic vector fields to solve problems related to these fields. The book deals with the needs of turbulence in relation to stochastic vector fields, particularly, on three-dimensional aspects, linear problems, and stochastic model building. The text describes probability distributions and densities, including Lebesgue integration, conditional probabilities, conditional expectations, statistical independence, lack of correlation. The book also explains the significance of the moments, the properties of the

  2. The effectiveness of low-level laser therapy on pain, self-reported hand function, and grip strength compared to placebo or "sham" treatment for adults with carpal tunnel syndrome: A systematic review.

    Science.gov (United States)

    Burger, Marlette; Kriel, Réna; Damon, Andrea; Abel, Amy; Bansda, Anisha; Wakens, Marinique; Ernstzen, Dawn

    2017-03-01

    Carpal tunnel syndrome (CTS) is one of the most common peripheral neuropathies in the upper extremity. The aim of this review was to systematically and critically appraise the available literature for the effectiveness of Low-Level Laser Therapy (LLLT) on pain, self-reported hand function, and grip strength compared to placebo treatment in adults with CTS. Seven databases were searched from 2000 to March 2015 namely: Cinahl, Cochrane Library, EBSCOhost, PEDro, PubMed, Science Direct, and Scopus. Key search terms were: CTS, LLLT, and physiotherapy. Specific inclusion and exclusion criteria were applied. The methodological quality was appraised with the PEDro scale. Data were extracted and captured on an Excel spreadsheet. The nine included randomized control trials (RCTs) had an average score of 8.2/11 according to the PEDro scale. The heterogeneity of the LLLT regimes used made statistical pooling inappropriate for this review and results were described narratively. No strong evidence exists concerning the effects of LLLT on CTS in adults. Studies that used 780-860 nm Lasers and energy dosages of 9-11 J/cm(2) or 10.8 J reported a more favorable outcome for pain, symptom severity, and functional ability as well as grip strength at the end of treatment and short-term follow up.

  3. Tool Gear Documentation

    Energy Technology Data Exchange (ETDEWEB)

    May, J; Gyllenhaal, J

    2002-04-03

    Tool Gear is designed to allow tool developers to insert instrumentation code into target programs using the DPCL library. This code can gather data and send it back to the Client for display or analysis. Tools can use the Tool Gear client without using the DPCL Collector. Any collector using the right protocols can send data to the Client for display and analysis. However, this document will focus on how to gather data with the DPCL Collector. There are three parts to the task of using Tool Gear to gather data through DPCL: (1) Write the instrumentation code that will be loaded and run in the target program. The code should be in the form of one or more functions, which can pass data structures back to the Client by way of DPCL. The collections of functions is compiled into a library, as described in this report. (2) Write the code that tells the DPCL Collector about the instrumentation and how to forward data back to the Client. (3) Extend the client to accept data from the Collector and display it in a useful way. The rest of this report describes how to carry out each of these steps.

  4. Large Crater Clustering tool

    Science.gov (United States)

    Laura, Jason; Skinner, James A.; Hunter, Marc A.

    2017-08-01

    In this paper we present the Large Crater Clustering (LCC) tool set, an ArcGIS plugin that supports the quantitative approximation of a primary impact location from user-identified locations of possible secondary impact craters or the long-axes of clustered secondary craters. The identification of primary impact craters directly supports planetary geologic mapping and topical science studies where the chronostratigraphic age of some geologic units may be known, but more distant features have questionable geologic ages. Previous works (e.g., McEwen et al., 2005; Dundas and McEwen, 2007) have shown that the source of secondary impact craters can be estimated from secondary impact craters. This work adapts those methods into a statistically robust tool set. We describe the four individual tools within the LCC tool set to support: (1) processing individually digitized point observations (craters), (2) estimating the directional distribution of a clustered set of craters, back projecting the potential flight paths (crater clusters or linearly approximated catenae or lineaments), (3) intersecting projected paths, and (4) intersecting back-projected trajectories to approximate the local of potential source primary craters. We present two case studies using secondary impact features mapped in two regions of Mars. We demonstrate that the tool is able to quantitatively identify primary impacts and supports the improved qualitative interpretation of potential secondary crater flight trajectories.

  5. Climate Change and Water Tools

    Science.gov (United States)

    EPA tools and workbooks guide users to mitigate and adapt to climate change impacts. Various tools can help manage risks, others can visualize climate projections in maps. Included are comprehensive tool kits hosted by other federal agencies.

  6. New Conceptual Design Tools

    DEFF Research Database (Denmark)

    Pugnale, Alberto; Holst, Malene; Kirkegaard, Poul Henning

    2010-01-01

    This paper aims to discuss recent approaches in using more and more frequently computer tools as supports for the conceptual design phase of the architectural project. The present state-of-the-art about software as conceptual design tool could be summarized in two parallel tendencies. On the one...... hand, the main software houses are trying to introduce powerful and effective user-friendly applications in the world of building designers, that are more and more able to fit their specific requirements; on the other hand, some groups of expert users with a basic programming knowledge seem to deal...... with the problem of software as conceptual design tool by means of 'scripting', in other words by self-developing codes able to solve specific and well defined design problems. Starting with a brief historical recall and the discussion of relevant researches and practical experiences, this paper investigates...

  7. Cataract Surgery Tool

    Science.gov (United States)

    1977-01-01

    The NASA-McGannon cataract surgery tool is a tiny cutter-pump which liquefies and pumps the cataract lens material from the eye. Inserted through a small incision in the cornea, the tool can be used on the hardest cataract lens. The cutter is driven by a turbine which operates at about 200,000 revolutions per minute. Incorporated in the mechanism are two passages for saline solutions, one to maintain constant pressure within the eye, the other for removal of the fragmented lens material and fluids. Three years of effort have produced a design, now being clinically evaluated, with excellent potential for improved cataract surgery. The use of this tool is expected to reduce the patient's hospital stay and recovery period significantly.

  8. C-TOOL

    DEFF Research Database (Denmark)

    Taghizadeh-Toosi, Arezoo; Christensen, Bent Tolstrup; Hutchings, Nicholas John

    2014-01-01

    Soil organic carbon (SOC) is a significant component of the global carbon (C) cycle. Changes in SOC storage affect atmospheric CO2 concentrations on decadal to centennial timescales. The C-TOOL model was developed to simulate farm- and regional-scale effects of management on medium- to long......-term SOC storage in the profile of well-drained agricultural mineral soils. C-TOOL uses three SOC pools for both the topsoil (0–25 cm) and the subsoil (25–100 cm), and applies temperature-dependent first order kinetics to regulate C turnover. C-TOOL also enables the simulation of 14C turnover. The simple...... model structure facilitates calibration and requires few inputs (mean monthly air temperature, soil clay content, soil C/N ratio and C in organic inputs). The model was parameterised using data from 19 treatments drawn from seven long-term field experiments in the United Kingdom, Sweden and Denmark...

  9. RSP Tooling Technology

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-11-20

    RSP Tooling{trademark} is a spray forming technology tailored for producing molds and dies. The approach combines rapid solidification processing and net-shape materials processing in a single step. The general concept involves converting a mold design described by a CAD file to a tooling master using a suitable rapid prototyping (RP) technology such as stereolithography. A pattern transfer is made to a castable ceramic, typically alumina or fused silica (Figure 1). This is followed by spray forming a thick deposit of a tooling alloy on the pattern to capture the desired shape, surface texture, and detail. The resultant metal block is cooled to room temperature and separated from the pattern. The deposit's exterior walls are machined square, allowing it to be used as an insert in a standard mold base. The overall turnaround time for tooling is about 3 to 5 days, starting with a master. Molds and dies produced in this way have been used in high volume production runs in plastic injection molding and die casting. A Cooperative Research and Development Agreement (CRADA) between the Idaho National Engineering and Environmental Laboratory (INEEL) and Grupo Vitro has been established to evaluate the feasibility of using RSP Tooling technology for producing molds and dies of interest to Vitro. This report summarizes results from Phase I of this agreement, and describes work scope and budget for Phase I1 activities. The main objective in Phase I was to demonstrate the feasibility of applying the Rapid Solidification Process (RSP) Tooling method to produce molds for the manufacture of glass and other components of interest to Vitro. This objective was successfully achieved.

  10. RSP Tooling Technology

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-11-20

    RSP Tooling{trademark} is a spray forming technology tailored for producing molds and dies. The approach combines rapid solidification processing and net-shape materials processing in a single step. The general concept involves converting a mold design described by a CAD file to a tooling master using a suitable rapid prototyping (RP) technology such as stereolithography. A pattern transfer is made to a castable ceramic, typically alumina or fused silica (Figure 1). This is followed by spray forming a thick deposit of a tooling alloy on the pattern to capture the desired shape, surface texture, and detail. The resultant metal block is cooled to room temperature and separated from the pattern. The deposit's exterior walls are machined square, allowing it to be used as an insert in a standard mold base. The overall turnaround time for tooling is about 3 to 5 days, starting with a master. Molds and dies produced in this way have been used in high volume production runs in plastic injection molding and die casting. A Cooperative Research and Development Agreement (CRADA) between the Idaho National Engineering and Environmental Laboratory (INEEL) and Grupo Vitro has been established to evaluate the feasibility of using RSP Tooling technology for producing molds and dies of interest to Vitro. This report summarizes results from Phase I of this agreement, and describes work scope and budget for Phase I1 activities. The main objective in Phase I was to demonstrate the feasibility of applying the Rapid Solidification Process (RSP) Tooling method to produce molds for the manufacture of glass and other components of interest to Vitro. This objective was successfully achieved.

  11. Rapid SAW Sensor Development Tools

    Science.gov (United States)

    Wilson, William C.; Atkinson, Gary M.

    2007-01-01

    The lack of integrated design tools for Surface Acoustic Wave (SAW) devices has led us to develop tools for the design, modeling, analysis, and automatic layout generation of SAW devices. These tools enable rapid development of wireless SAW sensors. The tools developed have been designed to integrate into existing Electronic Design Automation (EDA) tools to take advantage of existing 3D modeling, and Finite Element Analysis (FEA). This paper presents the SAW design, modeling, analysis, and automated layout generation tools.

  12. The GNEMRE Dendro Tool.

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion John

    2007-10-01

    The GNEMRE Dendro Tool provides a previously unrealized analysis capability in the field of nuclear explosion monitoring. Dendro Tool allows analysts to quickly and easily determine the similarity between seismic events using the waveform time-series for each of the events to compute cross-correlation values. Events can then be categorized into clusters of similar events. This analysis technique can be used to characterize historical archives of seismic events in order to determine many of the unique sources that are present. In addition, the source of any new events can be quickly identified simply by comparing the new event to the historical set.

  13. General purpose MDE tools

    Directory of Open Access Journals (Sweden)

    Juan Manuel Cueva Lovelle

    2008-12-01

    Full Text Available MDE paradigm promises to release developers from writing code. The basis of this paradigm consists in working at such a level of abstraction that will make it easyer for analysts to detail the project to be undertaken. Using the model described by analysts, software tools will do the rest of the task, generating software that will comply with customer's defined requirements. The purpose of this study is to compare general purpose tools available right now that enable to put in practice the principles of this paradigm and aimed at generating a wide variety of applications composed by interactive multimedia and artificial intelligence components.

  14. Tool nimega Sacco

    Index Scriptorium Estoniae

    1998-01-01

    Kolmekümneseks on saanud Zanotta kott ehk tool "Sacco", mille 1968. a. disainisid P. Gatti, C. Paolini, F. Teodoro. "Sacco" - polüstüreenist graanulitega täidetud kott. Tähelepanu pälvis ka Zanotta firma täispuhutav tool "Blow" (1967, Scholari, D'Urbino, Lomazzi, De Pas). E. Lucie-Smith neist. 1968. aastale on pühendatud Düsseldorfi Kunstimuuseumi näitus "1968. a. legendid ja sümbolid", kus on eksponeeritud ligi 500 objekti ja mitu rekonstrueeritud interjööri

  15. Tool nimega Sacco

    Index Scriptorium Estoniae

    1998-01-01

    Kolmekümneseks on saanud Zanotta kott ehk tool "Sacco", mille 1968. a. disainisid P. Gatti, C. Paolini, F. Teodoro. "Sacco" - polüstüreenist graanulitega täidetud kott. Tähelepanu pälvis ka Zanotta firma täispuhutav tool "Blow" (1967, Scholari, D'Urbino, Lomazzi, De Pas). E. Lucie-Smith neist. 1968. aastale on pühendatud Düsseldorfi Kunstimuuseumi näitus "1968. a. legendid ja sümbolid", kus on eksponeeritud ligi 500 objekti ja mitu rekonstrueeritud interjööri

  16. Change Detection Tools

    NARCIS (Netherlands)

    Dekker, R.J.; Kuenzer, C.; Lehner, M.; Reinartz, P.; Niemeyer, I.; Nussbaum, S.; Lacroix, V.; Sequeira, V.; Stringa, E.; Schöpfer, E.

    2009-01-01

    In this chapter a wide range of change detection tools is addressed. They are grouped into methods suitable for optical and multispectral data, synthetic aperture radar (SAR) images, and 3D data. Optical and multispectral methods include unsupervised approaches, supervised and knowledge-based approa

  17. Social Data Analytics Tool

    DEFF Research Database (Denmark)

    Hussain, Abid; Vatrapu, Ravi

    2014-01-01

    This paper presents the design, development and demonstrative case studies of the Social Data Analytics Tool, SODATO. Adopting Action Design Framework [1], the objective of SODATO [2] is to collect, store, analyze, and report big social data emanating from the social media engagement of and social...

  18. Healthy Homes Tools

    Science.gov (United States)

    Peek, Gina; Lyon, Melinda; Russ, Randall

    2012-01-01

    Extension is focusing on healthy homes programming. Extension educators are not qualified to diagnose consumers' medical problems as they relate to housing. We cannot give medical advice. Instead, we can help educate consumers about home conditions that may affect their well-being. Extension educators need appropriate healthy homes tools to…

  19. The science writing tool

    Science.gov (United States)

    Schuhart, Arthur L.

    This is a two-part dissertation. The primary part is the text of a science-based composition rhetoric and reader called The Science Writing Tool. This textbook has seven chapters dealing with topics in Science Rhetoric. Each chapter includes a variety of examples of science writing, discussion questions, writing assignments, and instructional resources. The purpose of this text is to introduce lower-division college science majors to the role that rhetoric and communication plays in the conduct of Science, and how these skills contribute to a successful career in Science. The text is designed as a "tool kit," for use by an instructor constructing a science-based composition course or a writing-intensive Science course. The second part of this part of this dissertation reports on student reactions to draft portions of The Science Writing Tool text. In this report, students of English Composition II at Northern Virginia Community College-Annandale were surveyed about their attitudes toward course materials and topics included. The findings were used to revise and expand The Science Writing Tool.

  20. Incident Information Management Tool

    CERN Document Server

    Pejovic, Vladimir

    2015-01-01

    Flaws of\tcurrent incident information management at CMS and CERN\tare discussed. A new data\tmodel for future incident database is\tproposed and briefly described. Recently developed draft version of GIS-­‐based tool for incident tracking is presented.

  1. Tools in HRD. Symposium.

    Science.gov (United States)

    2002

    This document contains three papers from a symposium on tools in human resource development (HRD). "Game Theory Methodology in HRD" (Thomas J. Chermack, Richard A. Swanson) explores the utility of game theory in helping the HRD profession address the complexity of integrating multiple theories for disciplinary understanding and…

  2. Tools and Concepts.

    Science.gov (United States)

    Artis, Margaret, Ed.; And Others

    This guide provides enrichment for students to develop tools and concepts used in various areas of mathematics. The first part presents arithmetic progressions, geometric progressions, and harmonic progression. In the second section, the concept of mathematic induction is developed from intuitive induction, using concrete activities, to the…

  3. The Proteogenomic Mapping Tool

    Directory of Open Access Journals (Sweden)

    Dandass Yoginder S

    2011-04-01

    Full Text Available Abstract Background High-throughput mass spectrometry (MS proteomics data is increasingly being used to complement traditional structural genome annotation methods. To keep pace with the high speed of experimental data generation and to aid in structural genome annotation, experimentally observed peptides need to be mapped back to their source genome location quickly and exactly. Previously, the tools to do this have been limited to custom scripts designed by individual research groups to analyze their own data, are generally not widely available, and do not scale well with large eukaryotic genomes. Results The Proteogenomic Mapping Tool includes a Java implementation of the Aho-Corasick string searching algorithm which takes as input standardized file types and rapidly searches experimentally observed peptides against a given genome translated in all 6 reading frames for exact matches. The Java implementation allows the application to scale well with larger eukaryotic genomes while providing cross-platform functionality. Conclusions The Proteogenomic Mapping Tool provides a standalone application for mapping peptides back to their source genome on a number of operating system platforms with standard desktop computer hardware and executes very rapidly for a variety of datasets. Allowing the selection of different genetic codes for different organisms allows researchers to easily customize the tool to their own research interests and is recommended for anyone working to structurally annotate genomes using MS derived proteomics data.

  4. Clean Cities Tools

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-12-19

    The U.S. Department of Energy's Clean Cities offers a large collection of Web-based tools on the Alternative Fuels Data Center. These calculators, interactive maps, and data searches can assist fleets, fuels providers, and other transportation decision makers in their efforts to reduce petroleum use.

  5. Sight Application Analysis Tool

    Energy Technology Data Exchange (ETDEWEB)

    Bronevetsky, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-09-17

    The scale and complexity of scientific applications makes it very difficult to optimize, debug and extend them to support new capabilities. We have developed a tool that supports developers’ efforts to understand the logical flow of their applications and interactions between application components and hardware in a way that scales with application complexity and parallelism.

  6. Photutils: Photometry tools

    Science.gov (United States)

    Bradley, Larry; Sipocz, Brigitta; Robitaille, Thomas; Tollerud, Erik; Deil, Christoph; Vinícius, Zè; Barbary, Kyle; Günther, Hans Moritz; Bostroem, Azalee; Droettboom, Michael; Bray, Erik; Bratholm, Lars Andersen; Pickering, T. E.; Craig, Matt; Pascual, Sergio; Greco, Johnny; Donath, Axel; Kerzendorf, Wolfgang; Littlefair, Stuart; Barentsen, Geert; D'Eugenio, Francesco; Weaver, Benjamin Alan

    2016-09-01

    Photutils provides tools for detecting and performing photometry of astronomical sources. It can estimate the background and background rms in astronomical images, detect sources in astronomical images, estimate morphological parameters of those sources (e.g., centroid and shape parameters), and perform aperture and PSF photometry. Written in Python, it is an affiliated package of Astropy (ascl:1304.002).

  7. Dynamic multimedia annotation tool

    Science.gov (United States)

    Pfund, Thomas; Marchand-Maillet, Stephane

    2001-12-01

    Annotating image collections is crucial for different multimedia applications. Not only this provides an alternative access to visual information but it is a critical step to perform the evaluation of content-based image retrieval systems. Annotation is a tedious task so that there is a real need for developing tools that lighten the work of annotators. The tool should be flexible and offer customization so as to make the annotator the most comfortable. It should also automate the most tasks as possible. In this paper, we present a still image annotation tool that has been developed with the aim of being flexible and adaptive. The principle is to create a set of dynamic web pages that are an interface to a SQL database. The keyword set is fixed and every image receives from concurrent annotators a set of keywords along with time stamps and annotator Ids. Each annotator has the possibility of going back and forth within the collection and its previous annotations. He is helped by a number of search services and customization options. An administrative section allows the supervisor to control the parameter of the annotation, including the keyword set, given via an XML structure. The architecture of the tool is made flexible so as to accommodate further options through its development.

  8. Measurement and Research Tools.

    Science.gov (United States)

    1997

    This document contains four papers from a symposium on measurement and research tools for human resource development (HRD). "The 'Best Fit' Training: Measure Employee Learning Style Strengths" (Daniel L. Parry) discusses a study of the physiological aspect of sensory intake known as modality, more specifically, modality as measured by…

  9. Tools for Authentication

    Energy Technology Data Exchange (ETDEWEB)

    White, G

    2008-07-09

    Many recent Non-proliferation and Arms Control software projects include a software authentication component. In this context, 'authentication' is defined as determining that a software package performs only its intended purpose and performs that purpose correctly and reliably over many years. In addition to visual inspection by knowledgeable computer scientists, automated tools are needed to highlight suspicious code constructs both to aid the visual inspection and to guide program development. While many commercial tools are available for portions of the authentication task, they are proprietary, and have limited extensibility. An open-source, extensible tool can be customized to the unique needs of each project (projects can have both common and custom rules to detect flaws and security holes). Any such extensible tool must be based on a complete language compiler infrastructure, that is, one that can parse and digest the full language through its standard grammar. ROSE is precisely such a compiler infrastructure developed within DOE. ROSE is a robust source-to-source analysis and optimization infrastructure currently addressing large, million-line DOE applications in C, C++, and FORTRAN. This year, it has been extended to support the automated analysis of binaries. We continue to extend ROSE to address a number of security-specific requirements and apply it to software authentication for Non-proliferation and Arms Control projects. We will give an update on the status of our work.

  10. Google - Security Testing Tool

    OpenAIRE

    Staykov, Georgi

    2007-01-01

    Using Google as a security testing tool, basic and advanced search techniques using advanced google search operators. Examples of obtaining control over security cameras, VoIP systems, web servers and collecting valuable information as: Credit card details, cvv codes – only using Google.

  11. Organisational skills and tools.

    Science.gov (United States)

    Wicker, Paul

    2009-04-01

    While this article mainly applies to practitioners who have responsibilities for leading teams or supervising practitioners, many of the skills and tools described here may also apply to students or junior practitioners. The purpose of this article is to highlight some of the main points about organisation, some of the organisational skills and tools that are available, and some examples of how these skills and tools can be used to make practitioners more effective at organising their workload. It is important to realise that organising work and doing work are two completely different things and shouldn't be mixed up. For example, it would be very difficult to start organising work in the middle of a busy operating list: the organisation of the work must come before the work starts and therefore preparation is often an important first step in organising work. As such, some of the tools and skills described in this article may need to be used hours or even days prior to the actual work taking place.

  12. Nitrogen Trading Tool (NTT)

    Science.gov (United States)

    The Natural Resources Conservation Service (NRCS) recently developed a prototype web-based nitrogen trading tool to facilitate water quality credit trading. The development team has worked closely with the Agriculture Research Service Soil Plant Nutrient Research Unit (ARS-SPNR) and the Environmenta...

  13. Apple Shuns Tracking Tool

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Apple Inc. is advising software de- velopers to stop using a feature in software for its iPhones and iPads .that has been linked to privacyconcerns, a move that would also take away a widely used tool for tracking users and their behavior. Developers who write programs for Apple's lOS operating system have been using a unique.

  14. Balancing the tools

    DEFF Research Database (Denmark)

    Leroyer, Patrick

    2009-01-01

    The purpose of this article is to describe the potential of a new combination of functions in lexicographic tools for tourists. So far lexicography has focused on the communicative information needs of tourists, i.e. helping tourists decide what to say in a number of specific tourist situations, ...

  15. Digital Tectonic Tools

    DEFF Research Database (Denmark)

    Schmidt, Anne Marie Due

    2005-01-01

    in particular. A model of the aspects in the term tectonics – epresentation, ontology and culture – will be presented and used to discuss the current digital tools’ ability in tectonics. Furthermore it will be discussed what a digital tectonic tool is and could be and how a connection between the digital...

  16. Risk Management Implementation Tool

    Science.gov (United States)

    Wright, Shayla L.

    2004-01-01

    Continuous Risk Management (CM) is a software engineering practice with processes, methods, and tools for managing risk in a project. It provides a controlled environment for practical decision making, in order to assess continually what could go wrong, determine which risk are important to deal with, implement strategies to deal with those risk and assure the measure effectiveness of the implemented strategies. Continuous Risk Management provides many training workshops and courses to teach the staff how to implement risk management to their various experiments and projects. The steps of the CRM process are identification, analysis, planning, tracking, and control. These steps and the various methods and tools that go along with them, identification, and dealing with risk is clear-cut. The office that I worked in was the Risk Management Office (RMO). The RMO at NASA works hard to uphold NASA s mission of exploration and advancement of scientific knowledge and technology by defining and reducing program risk. The RMO is one of the divisions that fall under the Safety and Assurance Directorate (SAAD). I worked under Cynthia Calhoun, Flight Software Systems Engineer. My task was to develop a help screen for the Continuous Risk Management Implementation Tool (RMIT). The Risk Management Implementation Tool will be used by many NASA managers to identify, analyze, track, control, and communicate risks in their programs and projects. The RMIT will provide a means for NASA to continuously assess risks. The goals and purposes for this tool is to provide a simple means to manage risks, be used by program and project managers throughout NASA for managing risk, and to take an aggressive approach to advertise and advocate the use of RMIT at each NASA center.

  17. Extended Testability Analysis Tool

    Science.gov (United States)

    Melcher, Kevin; Maul, William A.; Fulton, Christopher

    2012-01-01

    The Extended Testability Analysis (ETA) Tool is a software application that supports fault management (FM) by performing testability analyses on the fault propagation model of a given system. Fault management includes the prevention of faults through robust design margins and quality assurance methods, or the mitigation of system failures. Fault management requires an understanding of the system design and operation, potential failure mechanisms within the system, and the propagation of those potential failures through the system. The purpose of the ETA Tool software is to process the testability analysis results from a commercial software program called TEAMS Designer in order to provide a detailed set of diagnostic assessment reports. The ETA Tool is a command-line process with several user-selectable report output options. The ETA Tool also extends the COTS testability analysis and enables variation studies with sensor sensitivity impacts on system diagnostics and component isolation using a single testability output. The ETA Tool can also provide extended analyses from a single set of testability output files. The following analysis reports are available to the user: (1) the Detectability Report provides a breakdown of how each tested failure mode was detected, (2) the Test Utilization Report identifies all the failure modes that each test detects, (3) the Failure Mode Isolation Report demonstrates the system s ability to discriminate between failure modes, (4) the Component Isolation Report demonstrates the system s ability to discriminate between failure modes relative to the components containing the failure modes, (5) the Sensor Sensor Sensitivity Analysis Report shows the diagnostic impact due to loss of sensor information, and (6) the Effect Mapping Report identifies failure modes that result in specified system-level effects.

  18. Tool handling robot system; Tool handling robot system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-10

    As an example of the delivery of industrial use automation equipment by Meidensha Corp., the paper introduced a tool handling robot system. The system is a tool handling robot of case processing use FMS (flexible manufacturing system). This is a system which exchanges tool automatically according to the From To order from the managing computer using the ceiling running robot between five horizontal type machining centers and more than 800 collective tool stockers. The structure of the system is as follows: tool handling robot (MHR-400), robot controller (meirocs-F), tool hand, robot running unit, tool stocker (for 844 tools), five life tool exchange trucks, tool truck lifting unit, system control panel. (NEDO)

  19. EVALUATION OF MACHINE TOOL QUALITY

    Directory of Open Access Journals (Sweden)

    Ivan Kuric

    2011-12-01

    Full Text Available Paper deals with aspects of quality and accuracy of machine tools. As the accuracy of machine tools has key factor for product quality, it is important to know the methods for evaluation of quality and accuracy of machine tools. Several aspects of diagnostics of machine tools are described, such as aspects of reliability.

  20. Web Tools: The Second Generation

    Science.gov (United States)

    Pascopella, Angela

    2008-01-01

    Web 2.0 tools and technologies, or second generation tools, help districts to save time and money, and eliminate the need to transfer or move files back and forth across computers. Many Web 2.0 tools help students think critically and solve problems, which falls under the 21st-century skills. The second-generation tools are growing in popularity…

  1. Web Tools: The Second Generation

    Science.gov (United States)

    Pascopella, Angela

    2008-01-01

    Web 2.0 tools and technologies, or second generation tools, help districts to save time and money, and eliminate the need to transfer or move files back and forth across computers. Many Web 2.0 tools help students think critically and solve problems, which falls under the 21st-century skills. The second-generation tools are growing in popularity…

  2. Automated Standard Hazard Tool

    Science.gov (United States)

    Stebler, Shane

    2014-01-01

    The current system used to generate standard hazard reports is considered cumbersome and iterative. This study defines a structure for this system's process in a clear, algorithmic way so that standard hazard reports and basic hazard analysis may be completed using a centralized, web-based computer application. To accomplish this task, a test server is used to host a prototype of the tool during development. The prototype is configured to easily integrate into NASA's current server systems with minimal alteration. Additionally, the tool is easily updated and provides NASA with a system that may grow to accommodate future requirements and possibly, different applications. Results of this project's success are outlined in positive, subjective reviews complete by payload providers and NASA Safety and Mission Assurance personnel. Ideally, this prototype will increase interest in the concept of standard hazard automation and lead to the full-scale production of a user-ready application.

  3. Algal functional annotation tool

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, D. [UCLA; Casero, D. [UCLA; Cokus, S. J. [UCLA; Merchant, S. S. [UCLA; Pellegrini, M. [UCLA

    2012-07-01

    The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on KEGG pathway maps and batch gene identifier conversion.

  4. Building energy analysis tool

    Science.gov (United States)

    Brackney, Larry; Parker, Andrew; Long, Nicholas; Metzger, Ian; Dean, Jesse; Lisell, Lars

    2016-04-12

    A building energy analysis system includes a building component library configured to store a plurality of building components, a modeling tool configured to access the building component library and create a building model of a building under analysis using building spatial data and using selected building components of the plurality of building components stored in the building component library, a building analysis engine configured to operate the building model and generate a baseline energy model of the building under analysis and further configured to apply one or more energy conservation measures to the baseline energy model in order to generate one or more corresponding optimized energy models, and a recommendation tool configured to assess the one or more optimized energy models against the baseline energy model and generate recommendations for substitute building components or modifications.

  5. Fluid blade disablement tool

    Energy Technology Data Exchange (ETDEWEB)

    Jakaboski, Juan-Carlos [Albuquerque, NM; Hughs, Chance G [Albuquerque, NM; Todd, Steven N [Rio Rancho, NM

    2012-01-10

    A fluid blade disablement (FBD) tool that forms both a focused fluid projectile that resembles a blade, which can provide precision penetration of a barrier wall, and a broad fluid projectile that functions substantially like a hammer, which can produce general disruption of structures behind the barrier wall. Embodiments of the FBD tool comprise a container capable of holding fluid, an explosive assembly which is positioned within the container and which comprises an explosive holder and explosive, and a means for detonating. The container has a concavity on the side adjacent to the exposed surface of the explosive. The position of the concavity relative to the explosive and its construction of materials with thicknesses that facilitate inversion and/or rupture of the concavity wall enable the formation of a sharp and coherent blade of fluid advancing ahead of the detonation gases.

  6. Automatically-Programed Machine Tools

    Science.gov (United States)

    Purves, L.; Clerman, N.

    1985-01-01

    Software produces cutter location files for numerically-controlled machine tools. APT, acronym for Automatically Programed Tools, is among most widely used software systems for computerized machine tools. APT developed for explicit purpose of providing effective software system for programing NC machine tools. APT system includes specification of APT programing language and language processor, which executes APT statements and generates NC machine-tool motions specified by APT statements.

  7. Micromachining with Nanostructured Cutting Tools

    CERN Document Server

    Jackson, Mark J

    2013-01-01

    The purpose of the brief is to explain how nanostructured tools can be used to machine materials at the microscale.  The aims of the brief are to explain to readers how to apply nanostructured tools to micromachining applications. This book describes the application of nanostructured tools to machining engineering materials and includes methods for calculating basic features of micromachining. It explains the nature of contact between tools and work pieces to build a solid understanding of how nanostructured tools are made.

  8. Automatically-Programed Machine Tools

    Science.gov (United States)

    Purves, L.; Clerman, N.

    1985-01-01

    Software produces cutter location files for numerically-controlled machine tools. APT, acronym for Automatically Programed Tools, is among most widely used software systems for computerized machine tools. APT developed for explicit purpose of providing effective software system for programing NC machine tools. APT system includes specification of APT programing language and language processor, which executes APT statements and generates NC machine-tool motions specified by APT statements.

  9. Program Management Tool

    Science.gov (United States)

    Gawadiak, Yuri; Wong, Alan; Maluf, David; Bell, David; Gurram, Mohana; Tran, Khai Peter; Hsu, Jennifer; Yagi, Kenji; Patel, Hemil

    2007-01-01

    The Program Management Tool (PMT) is a comprehensive, Web-enabled business intelligence software tool for assisting program and project managers within NASA enterprises in gathering, comprehending, and disseminating information on the progress of their programs and projects. The PMT provides planning and management support for implementing NASA programmatic and project management processes and requirements. It provides an online environment for program and line management to develop, communicate, and manage their programs, projects, and tasks in a comprehensive tool suite. The information managed by use of the PMT can include monthly reports as well as data on goals, deliverables, milestones, business processes, personnel, task plans, monthly reports, and budgetary allocations. The PMT provides an intuitive and enhanced Web interface to automate the tedious process of gathering and sharing monthly progress reports, task plans, financial data, and other information on project resources based on technical, schedule, budget, and management criteria and merits. The PMT is consistent with the latest Web standards and software practices, including the use of Extensible Markup Language (XML) for exchanging data and the WebDAV (Web Distributed Authoring and Versioning) protocol for collaborative management of documents. The PMT provides graphical displays of resource allocations in the form of bar and pie charts using Microsoft Excel Visual Basic for Application (VBA) libraries. The PMT has an extensible architecture that enables integration of PMT with other strategic-information software systems, including, for example, the Erasmus reporting system, now part of the NASA Integrated Enterprise Management Program (IEMP) tool suite, at NASA Marshall Space Flight Center (MSFC). The PMT data architecture provides automated and extensive software interfaces and reports to various strategic information systems to eliminate duplicative human entries and minimize data integrity

  10. Field Information Support Tool

    Science.gov (United States)

    2010-09-01

    collected by the GATER toolset is primarily used for visualization (ArcGIS and GIS online capabilities), incorporating this capability into a smaller...screen shot (4) ArcInfo. ArcInfo, a graphical information system application from ESRI, is arguably the most prolific GIS software application in... cartography tools. ArcInfo is used daily in the DoD to create, edit, and analyze data in order to make better decisions, faster. ArcInfo is the de facto

  11. Channel nut tool

    Energy Technology Data Exchange (ETDEWEB)

    Olson, Marvin

    2016-01-12

    A method, system, and apparatus for installing channel nuts includes a shank, a handle formed on a first end of a shank, and an end piece with a threaded shaft configured to receive a channel nut formed on the second end of the shaft. The tool can be used to insert or remove a channel nut in a channel framing system and then removed from the channel nut.

  12. Udder Hygiene Analysis tool

    OpenAIRE

    2013-01-01

    In this report, the pilot of UHC is described. The main objective of the pilot is to make farmers more aware of how to increase udder health in dairy herds. This goes through changing management aspects related to hygiene. This report firstly provides general information about antibiotics and the processes that influence udder health. Secondly, six subjects are described related to udder health. Thirdly, the tools (checklists and roadmap) are shown and fourthly, advises that are written by UH...

  13. Knowing about tools: neural correlates of tool familiarity and experience.

    Science.gov (United States)

    Vingerhoets, Guy

    2008-04-15

    The observation of tools is known to elicit a distributed cortical network that reflects close-knit relations of semantic, action-related, and perceptual knowledge. The neural correlates underlying the critical knowledge of skilled tool use, however, remain to be elucidated. In this study, functional magnetic resonance imaging in 14 volunteers compares neural activation during the observation of familiar tools versus equally graspable unfamiliar tools of which the observers have little, if any, functional knowledge. In a second paradigm, the level of tool-experience is investigated by comparing the neural effects of observing frequently versus infrequently used familiar tools. Both familiar and unfamiliar tools activate the classic neural network associated with tool representations. Direct comparison of the activation patterns during the observation of familiar and unfamiliar tools in a priori determined regions of interest (ptool-use knowledge, with supramarginal gyrus storing information about limb and hand positions, and precuneus storing visuospatial information about hand-tool interactions. As no frontal activation survived this contrast, it appears that premotor activity is unrelated to experience based motor knowledge of tool use/function, but rather, is elicited by any graspable tool. Confrontation with unfamiliar or infrequently used tools reveals an increase in inferior temporal and medial and lateral occipital activation, predominantly in the left hemisphere, suggesting that these regions reflect visual feature processing for tool identification.

  14. Dynamic Contingency Analysis Tool

    Energy Technology Data Exchange (ETDEWEB)

    2016-01-14

    The Dynamic Contingency Analysis Tool (DCAT) is an open-platform and publicly available methodology to help develop applications that aim to improve the capabilities of power system planning engineers to assess the impact and likelihood of extreme contingencies and potential cascading events across their systems and interconnections. Outputs from the DCAT will help find mitigation solutions to reduce the risk of cascading outages in technically sound and effective ways. The current prototype DCAT implementation has been developed as a Python code that accesses the simulation functions of the Siemens PSS�E planning tool (PSS/E). It has the following features: It uses a hybrid dynamic and steady-state approach to simulating the cascading outage sequences that includes fast dynamic and slower steady-state events. It integrates dynamic models with protection scheme models for generation, transmission, and load. It models special protection systems (SPSs)/remedial action schemes (RASs) and automatic and manual corrective actions. Overall, the DCAT attempts to bridge multiple gaps in cascading-outage analysis in a single, unique prototype tool capable of automatically simulating and analyzing cascading sequences in real systems using multiprocessor computers.While the DCAT has been implemented using PSS/E in Phase I of the study, other commercial software packages with similar capabilities can be used within the DCAT framework.

  15. Dynamic Contingency Analysis Tool

    Energy Technology Data Exchange (ETDEWEB)

    2016-01-14

    The Dynamic Contingency Analysis Tool (DCAT) is an open-platform and publicly available methodology to help develop applications that aim to improve the capabilities of power system planning engineers to assess the impact and likelihood of extreme contingencies and potential cascading events across their systems and interconnections. Outputs from the DCAT will help find mitigation solutions to reduce the risk of cascading outages in technically sound and effective ways. The current prototype DCAT implementation has been developed as a Python code that accesses the simulation functions of the Siemens PSS/E planning tool (PSS/E). It has the following features: It uses a hybrid dynamic and steady-state approach to simulating the cascading outage sequences that includes fast dynamic and slower steady-state events. It integrates dynamic models with protection scheme models for generation, transmission, and load. It models special protection systems (SPSs)/remedial action schemes (RASs) and automatic and manual corrective actions. Overall, the DCAT attempts to bridge multiple gaps in cascading-outage analysis in a single, unique prototype tool capable of automatically simulating and analyzing cascading sequences in real systems using multiprocessor computers.While the DCAT has been implemented using PSS/E in Phase I of the study, other commercial software packages with similar capabilities can be used within the DCAT framework.

  16. Frequency Response Analysis Tool

    Energy Technology Data Exchange (ETDEWEB)

    Etingov, Pavel V.; Kosterev, Dmitry; Dai, T.

    2014-12-31

    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  17. Frequency Response Analysis Tool

    Energy Technology Data Exchange (ETDEWEB)

    Etingov, Pavel V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kosterev, Dmitry [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dai, T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-12-01

    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  18. Ergonomic redesign and evaluation of a clamping tool handle.

    Science.gov (United States)

    Jung, Myung-Chul; Hallbeck, M Susan

    2005-09-01

    The handle of a commercial bar clamp was redesigned using ergonomic principles and then compared with an original clamp. Ten male and ten female students participated in simulated clamping tasks under various conditions, including different clamping heights, clamping methods, and handle-gripping methods, with respect to the dependent variables of clamping and handle-squeezing forces. The results showed that the redesigned clamp produced larger clamping force with lower handle-squeezing forces than the original clamp. As expected, males exerted more force than females in both clamping and squeezing forces. A pistol grip method was superior to an upside-down handle-gripping method. Two-handed operation was recommended for this type of clamp by simultaneously pulling the trigger and sliding the bar in order to initially tighten around objects. This study shows that the application of ergonomic guidelines increases the efficiency and usability of manual handtools.

  19. Algal functional annotation tool

    Energy Technology Data Exchange (ETDEWEB)

    2012-07-12

    Abstract BACKGROUND: Progress in genome sequencing is proceeding at an exponential pace, and several new algal genomes are becoming available every year. One of the challenges facing the community is the association of protein sequences encoded in the genomes with biological function. While most genome assembly projects generate annotations for predicted protein sequences, they are usually limited and integrate functional terms from a limited number of databases. Another challenge is the use of annotations to interpret large lists of 'interesting' genes generated by genome-scale datasets. Previously, these gene lists had to be analyzed across several independent biological databases, often on a gene-by-gene basis. In contrast, several annotation databases, such as DAVID, integrate data from multiple functional databases and reveal underlying biological themes of large gene lists. While several such databases have been constructed for animals, none is currently available for the study of algae. Due to renewed interest in algae as potential sources of biofuels and the emergence of multiple algal genome sequences, a significant need has arisen for such a database to process the growing compendiums of algal genomic data. DESCRIPTION: The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes

  20. A prospective, multicenter, observational study on quality of life after laparoscopic inguinal hernia repair with ProGrip laparoscopic, self-fixating mesh according to the European Registry for Abdominal Wall Hernias Quality of Life Instrument.

    Science.gov (United States)

    Muysoms, Filip E; Vanlander, Aude; Ceulemans, Robrecht; Kyle-Leinhase, Iris; Michiels, Maarten; Jacobs, Ivo; Pletinckx, Pieter; Berrevoet, Frederik

    2016-11-01

    There is an increasing interest in patient-reported outcome measurement to evaluate hernia operations. Several hernia-specific quality of life (QoL) scales have been proposed, but none are constructed for preoperative assessment. The European Registry for Abdominal Wall Hernias (EuraHS) proposed the short, 9-question EuraHS-QoL instrument for assessment pre- and postoperatively. The EuraHS-QoL was evaluated in a prospective, multicenter validation study alongside the Visual Analogue Scale, Verbal Rating Scale, and Carolina Comfort Scale (https://clinicaltrials.gov; NCT01936584). We included 101 patients undergoing unilateral laparoscopic inguinal hernia repair with ProGrip laparoscopic, self-fixating mesh. Clinical follow-up at 12 months was 87% complete. The EuraHS-QoL score shows good internal consistency (Cronbach's α ≥ .90), good test-retest reliability (Spearman correlation coefficient r ≥ 0.72), and high correlation for pain with the Visual Analogue Scale, the Verbal Rating Scale, the Carolina Comfort Scale pain scale (r between 0.64 and 0.86), and for restriction of activity with the Carolina Comfort Scale movement scale (r between 0.65 and 0.79). Our results show significant improvement in quality of life at 3 weeks compared with preoperative and further significant improvement at 12 months (P 75%) or with a 95%) in the majority of the patients. The EuraHS-QoL instrument is a short and valid patient-reported outcome measurement following groin hernia repair. Laparoscopic inguinal hernia repair with ProGrip laparoscopic, self-fixating mesh results in a favorable outcome and significant improvement of quality of life compared with the preoperative assessment. Copyright © 2016 Elsevier Inc. All rights reserved.