La sal en el queso: diversas interacciones.

Directory of Open Access Journals (Sweden)

Juan Sabastián Ramírez-Navas

2016-12-01

Full Text Available El objetivo de este trabajo fue analizar el efecto de la sal sobre algunas propiedades físicas del queso, su interacción con los componentes del queso, y el efecto del contenido de sodio sobre la salud de los consumidores. La sal es un ingrediente importante, ya que determina en gran parte la calidad del producto y la aceptación del consumidor. El salado del queso tiene in uencia en la calidad debido a sus efectos sobre la composición, el crecimiento microbiano y la actividad enzimática. Ejerce una in uencia signi cativa sobre la reología y textura, así como en la maduración, principalmente a través de sus efectos sobre la actividad del agua. Los niveles de sal en queso van desde aproximadamente 0,6% p/p hasta aproximadamente 7% p/p. Debido a que el consumo de queso está aumentando en todo el mundo, se debe dar importancia a la reducción de la sal sin afectar su consumo. Entre las estrategias que se han planteado con tal n está la sustitución parcial de la sal por otros compuestos. Pero el inconveniente de la sustitución del NaCl es su efecto sobre las propiedades sensoriales, la composición química, la proteólisis y la textura del queso. Otra interesante alternativa para el reemplazo del NaCl, es el uso de la tecnología de membranas para obtener permeado rico en sales provenientes del lactosuero; la adición de estas sales en la elaboración quesera, produce quesos bajos en sodio, con buena textura.

Cinematic narratives of Sonderkommando: Son of saul or narrating the victim, perpetrator, trauma and death

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Daković Nevena

2016-01-01

Full Text Available The aim of this paper is to map out - by analysing the film Son of Saul, but also by its comparison with two other films dealing with the topic, Himmelkommando and The Grey Zone, the narrative mechanism that satisfies the complex ethical and aesthetical demands imposed by the theme of Sonderkommando as the particular episode of the Holocaust. The key element of the narrative structure is the construction of the Levi’s “dead and drowned” witness who “resurrected” through the narrative intervention becomes the only reliable and credible narrator of the historical trauma. The prerequisite for his emergence is the narration and representation of the death which makes but also solves the traumatised - understood as multiple, fragmented, opposed - identities of the members of the special squad. Their entangled identity involves the simultaneous presence of a victim, perpetrator, witness and the authentic narrator of the trauma of the death camp. The death of the perpetrator is the condition sina qua non for the emergence of the figure of the victim-witness narrator but also for making of narrative which overcomes the initial trauma of the Holocaust. The detailed analysis of the film Son of Saul confirms and identifies these narratives as the modernist narration of the post-traumatic film.

“ÁGUA VIRA SAL LÁ NA SALINA”: O GLOSSÁRIO DOS TERMOS DO SAL NO RIO GRANDE DO NORTE NUMA PERSPECTIVA SOCIOTERMINOLÓGICA

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Moisés Batista da Silva

2016-01-01

Full Text Available O presente trabalho tem como objetivo apresentarresultados da pesquisa sobre os termos usados na Indústriado sal, em três municípios que fazem parte da região salineirado Rio Grande do Norte. Primeiramente, abordamosas diferentes ciências do Léxico estudadas por Boutin--Quesnel (1985, Barbosa (1994,1995, Barros (2004,dando ênfase maior nas orientações teórico-metodológicasda Socioterminologia (FAULSTICH, 1995, 1996, 1998,2006. Em seguida, expomos os procedimentos tanto dametodologia de campo quanto da metodologia da organizaçãodo Glossário da Terminologia do Sal - GLOSSAL(SILVA, 2007. Depois, apresentamos uma amostra dosverbetes, as análises feitas a partir desse repertório e, porfim, as considerações finais quanto aos fatos linguísticos,observados nesse glossário. Desse modo, essa pesquisa sejustifica por possibilitar a divulgação de um produto terminográficodestinado, não só aos especialistas e pesquisadoresdas Ciências do Léxico, como também ao grandepúblico e aos interessados em aprofundar seus estudos naterminologia do sal.Palavras-chave: Sal. Indústria do Sal. Terminologia. Socioterminologia.Glossário.

A lecture by Saul Perlmutter, winner of the 2011 Nobel prize in physics

CERN Multimedia

2011-01-01

The CNRS National Institute of Nuclear Physics and Particle Physics (IN2P3), Pierre et Marie Curie University and the Laboratory of Nuclear and High-energy Physics (LPNHE) are happy to invite you to a talk by Nobel laureate Saul Perlmutter.   Perlmutter shared the 2011 Nobel prize in physics "for the discovery of the accelerating expansion of the Universe through observations of distant supernovae." He will give a public talk in Paris on 17 December at 5pm: "Supernovae, Dark Energy, and the Accelerating Universe" Amphithéâtre Farabeuf des Cordeliers 21, rue de l’école de Médecine 75006 Paris Free entrance (places are limited) and live translation available.

Characterisation of SalRAB a salicylic acid inducible positively regulated efflux system of Rhizobium leguminosarum bv viciae 3841.

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Adrian J Tett

Full Text Available Salicylic acid is an important signalling molecule in plant-microbe defence and symbiosis. We analysed the transcriptional responses of the nitrogen fixing plant symbiont, Rhizobium leguminosarum bv viciae 3841 to salicylic acid. Two MFS-type multicomponent efflux systems were induced in response to salicylic acid, rmrAB and the hitherto undescribed system salRAB. Based on sequence similarity salA and salB encode a membrane fusion and inner membrane protein respectively. salAB are positively regulated by the LysR regulator SalR. Disruption of salA significantly increased the sensitivity of the mutant to salicylic acid, while disruption of rmrA did not. A salA/rmrA double mutation did not have increased sensitivity relative to the salA mutant. Pea plants nodulated by salA or rmrA strains did not have altered nodule number or nitrogen fixation rates, consistent with weak expression of salA in the rhizosphere and in nodule bacteria. However, BLAST analysis revealed seventeen putative efflux systems in Rlv3841 and several of these were highly differentially expressed during rhizosphere colonisation, host infection and bacteroid differentiation. This suggests they have an integral role in symbiosis with host plants.

O Debate do Salário Mínimo no Brasil

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Sara Eloisa Vilmar da Silva Lemos

2011-04-01

Full Text Available Num contexto de estabilidade econômica, o salário mínimo pode voltar a desempenhar o seu papel original de tentar garantir ao trabalhador um salário que é o mínimo para a sua sobrevivência. Para a análise do papel do salario mínimo no mercado de trabalho brasileiro, uma resenha da literatura especifica existente parece ser um bom ponto de partida.

User Guide: How to Use and Operate Virtual Reality Equipment in the Systems Assessment and Usability Laboratory (SAUL) for Conducting Demonstrations

Science.gov (United States)

2017-08-01

Assessment and Usability Laboratory (SAUL) for Conducting Demonstrations by Michael N Geuss and Joseph A Campanelli Human Research and...Master unable to communicate with necessary computers .... 15 Fig. 14 PPT Studio N setup for 4 users...to communicate with each other and display the same virtual environment to multiple users. Cluster Master must be run on the computer running the

Estrategias mundiales en la reducción de sal/sodio en el pan

OpenAIRE

Mónica Valverde Guillén; Jennifer Picado Pérez

2013-01-01

Objetivo: Proporcionar información sobre las acciones mundiales en la reducción de sal/sodio en el pan para generar datos útiles en la implementación de estrategias que busquen la disminución del consumo de sal/sodio a partir de productos panificados. Método: Se realizó una búsqueda de información en las bases de datos de Binass, PubMed, Scielo e instituciones gubernamentales. Las palabras claves fueron: contenido de sodio en el pan, menos sodio en pan, acciones para reducir sal en el pan, co...

SalB inactivation modulates culture supernatant exoproteins and affects autolysis and viability in Enterococcus faecalis OG1RF.

Science.gov (United States)

Shankar, Jayendra; Walker, Rachel G; Wilkinson, Mark C; Ward, Deborah; Horsburgh, Malcolm J

2012-07-01

The culture supernatant fraction of an Enterococcus faecalis gelE mutant of strain OG1RF contained elevated levels of the secreted antigen SalB. Using differential fluorescence gel electrophoresis (DIGE) the salB mutant was shown to possess a unique complement of exoproteins. Differentially abundant exoproteins were identified using matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry. Stress-related proteins including DnaK, Dps family protein, SOD, and NADH peroxidase were present in greater quantity in the OG1RF salB mutant culture supernatant. Moreover, several proteins involved in cell wall synthesis and cell division, including d-Ala-d-Lac ligase and EzrA, were present in reduced quantity in OG1RF salB relative to the parent strain. The salB mutant displayed reduced viability and anomalous cell division, and these phenotypes were exacerbated in a gelE salB double mutant. An epistatic relationship between gelE and salB was not identified with respect to increased autolysis and cell morphological changes observed in the salB mutant. SalB was purified as a six-histidine-tagged protein to investigate peptidoglycan hydrolytic activity; however, activity was not evident. High-pressure liquid chromatography (HPLC) analysis of reduced muropeptides from peptidoglycan digested with mutanolysin revealed that the salB mutant and OG1RF were indistinguishable.

Molecular and neurochemical substrates of the audiogenic seizure strains: The GASH:Sal model.

Science.gov (United States)

Prieto-Martín, Ana I; Aroca-Aguilar, J Daniel; Sánchez-Sánchez, Francisco; Muñoz, Luis J; López, Dolores E; Escribano, Julio; de Cabo, Carlos

2017-06-01

Animal models of audiogenic epilepsy are useful tools to understand the mechanisms underlying human reflex epilepsies. There is accumulating evidence regarding behavioral, anatomical, electrophysiological, and genetic substrates of audiogenic seizure strains, but there are still aspects concerning their neurochemical basis that remain to be elucidated. Previous studies have shown the involved of γ-amino butyric acid (GABA) in audiogenic seizures. The aim of our research was to clarify the role of the GABAergic system in the generation of epileptic seizures in the genetic audiogenic seizure-prone hamster (GASH:Sal) strain. We studied the K + /Cl - cotransporter KCC2 and β2-GABAA-type receptor (GABAAR) and β3-GABAAR subunit expressions in the GASH:Sal both at rest and after repeated sound-induced seizures in different brain regions using the Western blot technique. We also sequenced the coding region for the KCC2 gene both in wild- type and GASH:Sal hamsters. Lower expression of KCC2 protein was found in GASH:Sal when compared with controls at rest in several brain areas: hippocampus, cortex, cerebellum, hypothalamus, pons-medulla, and mesencephalon. Repeated induction of seizures caused a decrease in KCC2 protein content in the inferior colliculus and hippocampus and an increase in the pons-medulla. When compared to controls, the basal β 2 -GABA A R subunit in the GASH:Sal was overexpressed in the inferior colliculus, rest of the mesencephalon, and cerebellum, whereas basal β 3 subunit levels were lower in the inferior colliculus and rest of the mesencephalon. Repeated seizures increased β2 both in the inferior colliculus and in the hypothalamus and β 3 in the hypothalamus. No differences in the KCC2 gene-coding region were found between GASH:Sal and wild-type hamsters. These data indicate that GABAergic system functioning is impaired in the GASH:Sal strain, and repeated seizures seem to aggravate this dysfunction. These results have potential clinical

The evolutionary history of the SAL1 gene family in eutherian mammals

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Callebaut Isabelle

2011-05-01

Full Text Available Abstract Background SAL1 (salivary lipocalin is a member of the OBP (Odorant Binding Protein family and is involved in chemical sexual communication in pig. SAL1 and its relatives may be involved in pheromone and olfactory receptor binding and in pre-mating behaviour. The evolutionary history and the selective pressures acting on SAL1 and its orthologous genes have not yet been exhaustively described. The aim of the present work was to study the evolution of these genes, to elucidate the role of selective pressures in their evolution and the consequences for their functions. Results Here, we present the evolutionary history of SAL1 gene and its orthologous genes in mammals. We found that (1 SAL1 and its related genes arose in eutherian mammals with lineage-specific duplications in rodents, horse and cow and are lost in human, mouse lemur, bushbaby and orangutan, (2 the evolution of duplicated genes of horse, rat, mouse and guinea pig is driven by concerted evolution with extensive gene conversion events in mouse and guinea pig and by positive selection mainly acting on paralogous genes in horse and guinea pig, (3 positive selection was detected for amino acids involved in pheromone binding and amino acids putatively involved in olfactory receptor binding, (4 positive selection was also found for lineage, indicating a species-specific strategy for amino acid selection. Conclusions This work provides new insights into the evolutionary history of SAL1 and its orthologs. On one hand, some genes are subject to concerted evolution and to an increase in dosage, suggesting the need for homogeneity of sequence and function in certain species. On the other hand, positive selection plays a role in the diversification of the functions of the family and in lineage, suggesting adaptive evolution, with possible consequences for speciation and for the reinforcement of prezygotic barriers.

Simon van der Stel en Constantia sal in my gedagtes bly. Die ...

African Journals Online (AJOL)

Simon van der Stel en Constantia sal in my gedagtes bly. Die byfigure sal nie vervaag nie en bo dit alles is, vir almal wat in die boeien- de verhaal 'n rol speel, die vraag aangaande die lotsbestemming van die mens gestel, 'n vraag waarop die skrywer Monica Dacosta laat antwoord: "Dutchmen never speak about destiny" [ ...

Synthesis, structural, thermal and optical studies of rare earth coordinated complex: Tb(Sal){sub 3}Phen

Energy Technology Data Exchange (ETDEWEB)

Kaur, Gagandeep; Dwivedi, Y. [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, Varanasi 221005 (India); Rai, S.B., E-mail: sbrai49@yahoo.co.in [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, Varanasi 221005 (India)

2011-11-01

Highlights: {yields} RE coordinated complex of Tb(Sal){sub 3}Phen in crystalline phases were synthesized. {yields} Enhancement in luminescence of Tb{sup 3+} was observed in complex on 355 nm excitation. {yields} Fluorescence enhancement is due to the efficient energy transfer from Sal to Tb{sup 3+}. {yields} An observed increase in lifetime of Tb{sup 3+} is due to encapsulation in Sal/Phen network. {yields} The present system is a deserving candidate for LSC when coupled with solar cells. - Abstract: Complexes of salicylic acid (Sal) and 1,10-phenanthroline (Phen) were synthesized coordinated with terbium ion (Tb{sup 3+}) in crystalline phases. The structural characterizations of the lanthanide complex were made using FT-IR, NMR ({sup 1}H and {sup 13}C) and XRD techniques. These measurements confirm the formation of Tb(Sal){sub 3}Phen complex structure. The thermal aspects of the complex were examined using DTA and TGA techniques. An enhancement in luminescence intensity of Tb{sup 3+} ion bands were observed in Tb(Sal){sub 3}Phen complex as compared to TbCl{sub 3} crystals on 355 nm laser excitation. Enhancement is reported due to the efficient energy transfer process from Sal to Tb{sup 3+} ions. This is also confirmed by the time resolved photoluminescence spectroscopy with increase in lifetime of Tb{sup 3+} ions due to encapsulation in Sal/Phen network. Our system in itself can be a deserving candidate for luminescent solar collector material when coupled with solar cells.

Erigeron mancus (Asteraceae) density as a baseline to detect future climate change in La Sal Mountain habitats

Science.gov (United States)

James F. Fowler; Barb Smith

2010-01-01

The La Sal Daisy, Erigeron mancus Rydb., is endemic to timberline and alpine habitats of the La Sal Mountains in Utah, an insular, laccolithic mountain range on the Colorado Plateau in southeastern Utah. It occurs in alpine herbaceous communities from timberline to the crestline of the La Sals. Our primary goal in this study was to measure basic population biology...

Striving for Diversity, Accessibility and Quality: Evaluating SiSAL Journal

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Jo Mynard

2014-06-01

Full Text Available After establishing a journal, it is important to evaluate its progress to ensure that the principles that underpin its existence continue to be a priority. In this article, the author reports on measures that were used to evaluate Studies in Self-Access Learning (SiSAL Journal. The research was designed to investigate the three principles that the journal values: diversity, accessibility and quality. The results identified some successful factors such as accessibility and favourable perceptions of SiSAL Journal’s quality. However, the results also identified areas that could be improved to further increase diversity and to encourage submissions from more authors based in different locations.

EJB 3.0 un EJB 2.0 salīdzinājums

OpenAIRE

Karnigins, Vadims

2013-01-01

Bakalaura darbā „EJB 3.0 un EJB 2.0 salīdzinājums” ir apskatītas atšķirības starp EJB 2.0 un EJB 3.0 tehnoloģijām - uzlabojumi tehnoloģijas trešajā versijā, salīdzinot ar otro, kā arī atšķirības programmēšanas pieejās, kas tiek diktētas ar EJB 3.0, salīdzinot ar EJB 2.0, un atšķirības starp 2. un 3. EJB tehnoloģijas versiju komponentēm. Darba praktiskajā daļā tiek apskatīta konkrētās Java EE lietotnes migrācija uz EJB 3.0 arhitektūru no EJB 2.0. Lietotne ir bankas karšu sistēmas sastāvdaļa...

The Safeguards Analytical Laboratory (SAL) in the Agency's safeguards measurement system activity in 1990

International Nuclear Information System (INIS)

Bagliano, G.; Cappis, J.; Deron, S.; Parus, J.L.

1991-05-01

The IAEA applies Safeguards at the request of a Member State to whole or part of its nuclear materials. The verification of nuclear material accountability still constitutes the fundamental method of control, although sealing and surveillance procedures play an important complementary and increasing role in Safeguards. A small fraction of samples must still be analyzed at independent analytical laboratories using conventional Destructive Analytical (DA) methods of highest accuracy in order to verify that small potential biases in the declarations of the State are not masking protracted diversions of significant quantities of fissile materials. The Safeguards Analytical Laboratory (SAL) is operated by the Agency's Laboratories at Seibersdorf to provide to the Department of Safeguards and its inspectors such off-site Analytical Services, in collaboration with the Network of Analytical Laboratories (NWAL) of the Agency. In the last years SAL and the Safeguards DA Services have become more directly involved in the qualification and utilization of on-site analytical instrumentation such as K-edge X-Ray absorptiometers and quadrupole mass spectrometers. The nature and the origin of the samples analyzed, the measurements usually requested by the IAEA inspectors, the methods and the analytical techniques available at SAL and at the Network of Analytical Laboratories (NWAL) with the performances achieved during the past years are described and discussed in several documents. This report gives an evaluation compared with 1989 of the volume and the quality of the analyses reported in 1990 by SAL and by the NWAL in reply to requests of IAEA Safeguards inspectors. The reports summarizes also on-site DA developments and support provided by SAL to the Division of Safeguards Operation and special training courses to the IAEA Safeguards inspectors. 55 refs, 7 figs, 15 tabs

Marx e a crítica à forma salário

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Carlos Prado

2011-09-01

Full Text Available

O objetivo desse artigo é descrever, a partir da leitura de “O Capital”, a crítica de Marx a forma salário. Tal categoria é fundamental para encobrir e mistificar as relações entre capital e trabalho. A partir de uma feroz crítica a Economia Política, Marx afirma que fetiche da forma salário cumpre a função de ocultar a apropriação da mais-valia pelo capitalista. Por conseguinte, trata-se de uma forma fundamental para a manutenção das relações capitalistas de produção.

The Phenomenology of Trauma. Sound and Haptic Sensuality in Son of Saul

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Vincze Teréz

2016-12-01

Full Text Available The winner of many prestigious prizes (Oscar for the best foreign language film, Grand Prize of the Cannes Film Festival, and the Golden Globe among them, the Hungarian film, Son of Saul – according to most critics – represents the Holocaust trauma in a completely new and intriguing way. The filmmakers have invented a special form in order to tackle the heroic task of showing the unwatchable, representing the unthinkable. In this essay I analyse the representational strategy of the film from a phenomenological point of view, and position it in the theoretical framework of haptic sensuality formulated by Vivian Sobchack and Laura U. Marks, among others. I mainly focus on the use of sound, in particular the role of sound design in the creation of haptic space. With the help of the analysis of the representation and artistic invocation of the different bodily senses in the film, I demonstrate how traditional artistic formal elements (characteristic of highly artistic, even experimental productions are combined with high impact effects often present in popular film forms. I argue that the successful combination of these two factors makes the film an example of artistic immersive cinema.1

SalMar ASA : Strategic analysis and valuation

OpenAIRE

Augenstein, Daniel

2017-01-01

The objective of this thesis is to estimate the theoretical value of equity for SalMar ASA and thereby the value per share at 27.11.2017. Fundamental valuation through a two-stage discounted cash flow model is chosen as the main method, while a valuation using comparable firms is performed as a supplement. In the fundamental valuation I have estimated the enterprise value by discounting the expected future cash flows to present value. To find the value of equity, the net-intere...

Reparation and validation of a large size dried spike: Batch SAL-9951

International Nuclear Information System (INIS)

Doubek, N.; Jammet, G.; Zoigner, A.

1991-02-01

To determine uranium and plutonium concentration using isotope dilution mass spectrometry, weighed aliquands of a synthetic mixture containing about 2mg of Pu (with a 239 Pu abundance of about 98%) and 37mg of U (with a 235 U enrichment of about 19%) have been prepared by the IAEA-SAL and verified by three analytical laboratories: NMCC-SAL, OEFZS, IAEA-SAL; they will be used to spike samples of concentrated spent fuel solutions with a high burnup and a low 235 U enrichment. Certified Reference Materials Pu-NBL-126, natural U-NBL-112A and 93% enriched U-NBL-116 were used to prepare a stock solution containing about 3.2 mg/ml of Pu and 64.3 mg/ml of 18.7% enriched U. Before shipment to the Reprocessing Plant, aliquands of the stock solution are dried to give Large Size Dried (LSD) Spikes which resist shocks encountered during transportation, so that they can readily be recovered quantitatively at the plant. This paper describes the preparation and the validation of a fifth batch of LSD-spike which is intended to be used as a common spike by the plant operator, the national and the IAEA inspectorates. 7 refs, 6 tabs

EFFECTS OF LAND-USE CHANGE ON THE PROPERTIES OF TOP SOIL OF DECIDUOUS SAL FOREST IN BANGLADESH

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M. A. Kashem

2016-08-01

Full Text Available This study examined the effects of land use change on the physico-chemical properties of top soil in the deciduous Sal forest of Bangladesh. Relatively less disturbed Sal (Shorea robusta Roxb. Ex Gaertn. forest stands and the nearby stands those were converted into Acacia (Acacia auriculiformis Benth. plantation and pineapple (Ananus comosus (L. Merr. cultivation were selected to examine the effects of land use change on soil properties. For each land use type, soil samples were collected from 4 locations, 50m distant from each other, as replicates. Soil samples were collected at 0-5, 5-10, and 10-15 cm depths. Soil moisture content, conductivity, pH organic C, total N and total P were determined as soil properties. Leaf litter of Sal, Acacia and pineapple was incubation for 90 and 180 days in independent identical soil in order to examine the effects of plant species through leaf litter on the soil chemical nutrient (N and P status. Data showed that soil moisture content, conductivity and pH were significantly affected by land use but not by depth. However, soil organic C was affected by both land-use type (P< 0.02 and soil depth (P< 0.003, although no significant interactions appeared between these two factors. Soil total N and P did not differ between land use types but by depth and, N and P contents decreased with the increase of depth. Rates of nutrients (N and P released from Sal, Acacia and pineapple did not differ significantly among them during incubation. Results of the present study reveal that properties of the top soil of the Madhupur Sal forest are different in their responses to the varying land uses. The findings of this study are thus relevant for the sustainable management of the deciduous Sal forest ecosystems.

Domates Salçalarının Mikroflorası ve Depolama Sürecinde Miktarlarındaki Değişiklikler

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Fikri Başoğlu

2015-02-01

Full Text Available - Ticari sterilize edilen domates salçasının muhafazası esnasında sterilliği azalmaktadır. 12 aylık muhafaza süresinde sterillik %100’den %15 ve 8’e hatta daha aza düşebilir. - Pastörizasyonda tatbik edilen sıcaklık derecesi (89-93 oC laktik asit bakterileri ile maya ve küflerin yaşamasına imkan vermemektedir. - Domates salçasının kalıntı mikroflorasını umumiyetle spor yapan bakteriler (B. subtilis, B. mesentericus, B. cereus ..... temsil etmektedir. - Domates salçasının kuru maddesi %28-30 veya %38-40 olması B. subtilis ve B. mesentericus’un ölmesine tesir etmemektedir. - Salçanın 10-15 oC ta muhafaza edilmesi termofil mikroorganizmaların çoğalmasına engel olmaktadır. - Salçanın pH’sı yükseltilirse sporlar çabuk gelişmektedir. - Hermetikli kapatmadaki hatalarda laktik asit bakterileri ve mayalar salçayı bozmaktadırlar. - Salçada bulunan bazı sporlu ve sporsuz mikroorganizmaların termal ölüm müddetlerine ortamın pH’sı, organik asitler ve spor konsantrasyonu etki etmektedir.

A recombinant Sal k 1 isoform as an alternative to the polymorphic allergen from Salsola kali pollen for allergy diagnosis.

Science.gov (United States)

Mas, Salvador; Boissy, Patrice; Monsalve, Rafael I; Cuesta-Herranz, Javier; Díaz-Perales, Araceli; Fernández, Javier; Colás, Carlos; Rodríguez, Rosalía; Barderas, Rodrigo; Villalba, Mayte

2015-01-01

The incidence of Amaranthaceae pollen allergy has increased due to the desertification occurring in many countries. In some regions of Spain, Salsola kali is the main cause of pollinosis, at almost the same level as olive and grass pollen. Sal k 1 - the sensitization marker of S. kali pollinosis - is used in clinical diagnosis, but is purified at a low yield from pollen. We aimed to produce a recombinant (r)Sal k 1 able to span the structural and immunological properties of the natural isoforms from pollen, and validate its potential use for diagnosis. Specific cDNA was amplified by PCR, cloned into the pET41b vector and used to transform BL21 (DE3) Escherichia coli cells. Immunoblotting, ELISA, basophil activation and skin-prick tests were used to validate the recombinant protein against Sal k 1 isolated from pollen. Sera and blood cells from S. kali pollen-sensitized patients and specific monoclonal and polyclonal antisera were used. rSal k 1 was produced in bacteria with a yield of 7.5 mg/l of cell culture. The protein was purified to homogeneity and structural and immunologically validated against the natural form. rSal k 1 exhibited a higher IgE cross-reactivity with plant-derived food extracts such as peanut, almond or tomato than with pollen sources such as Platanus acerifolia and Oleaceae members. rSal k 1 expressed in bacteria retains intact structural and immunological properties in comparison to the pollen-derived allergen. It spans the immunological properties of most of the isoforms found in pollen, and it might substitute natural Sal k 1 in clinical diagnosis. © 2015 S. Karger AG, Basel.

Performance and emission characteristics of an agricultural diesel engine fueled with blends of Sal methyl esters and diesel

International Nuclear Information System (INIS)

Pali, Harveer S.; Kumar, N.; Alhassan, Y.

2015-01-01

Highlights: • Sal seed oil is unexplored biodiesel feedstock which is abundantly found in India. • Sal seed oil has good oxidation stability. • Performance and emission characteristics of the blends of Sal methyl esters with diesel evaluated. • At higher loads, CO, HC and smoke emissions of SME blends were lower than diesel. - Abstract: The present work deals with an underutilized vegetable oil; Sal seed oil (Shorea robusta) as a feedstock for biodiesel production. The production potential of Sal seed oil is very promising (1.5 million tons in a year) in India. The pressure filtered Sal seed oil was transesterified into Sal Methyl Ester (SME). The kinematic viscosity (5.89 cSt), density (0.8764 g/cc) and calorific value (39.65 MJ/kg) of the SME were well within the ASTM/EN standard limits. Various test fuels were prepared for the engine trials by blending 10%, 20%, 30% and 40% of SME in diesel on volumetric basis and designated as SME10, SME20, SME30 and SME40 respectively. The BTE, in general, was found to be decreased with increased volume fraction of SME in the blends. At full load, BSEC for SME10, SME20, SME30 and SME40 were 13.6 MJ/kW h, 14.3 MJ/kW h, 14.7 MJ/kW h and 14.8 MJ/kW h respectively as compared to 13.9 MJ/kW h in case of diesel. At higher load conditions, CO, UHC and smoke emissions were found lower for all SME blends in comparison to neat diesel due to oxygenated nature of fuel. SME10, SME20, SME30 and SME40 showed 51 ppm, 44 ppm, 46 ppm and 48 ppm of UHC emissions respectively as compared to 60 ppm of diesel. The NOx emissions were found to be increased for SME based fuel in comparison to neat diesel operation. At peak load condition, SME10, SME20, SME30 and SME40 had NOx emissions of 612 ppm, 644 ppm, 689 ppm and 816 ppm as compared to 499 ppm for diesel. It may be concluded from the experimental investigations that Sal seed biodiesel is a potential alternative to diesel fuel for reducing dependence on crude petroleum derived fuels and

Avaliação dos efeitos da adição de sal e da densidade no transporte de tambaqui

Directory of Open Access Journals (Sweden)

Gomes Levy de Carvalho

2003-01-01

Full Text Available Os objetivos deste trabalho foram testar a eficiência do sal como redutor de estresse e verificar a melhor densidade de transporte de juvenis de tambaqui (Colossoma macropomun em caixas de plástico adaptadas. No primeiro experimento foram testadas diferentes concentrações de sal de cozinha (NaCl na água; no segundo, o transporte foi realizado por três horas em caixas de plástico de 200 L estocadas com diferentes densidades de peixe, com 8 g de sal/L de água. O cortisol plasmático dos peixes sofreu aumento significativo após o transporte no tratamento sem sal e com 2 g de sal/L de água, retornando para níveis normais após 96 horas. A glicose plasmática dos peixes sofreu aumento após o transporte em todas as concentrações de sal testadas, com exceção da com 8 g/L de água, retornando para níveis normais em 24 horas. Nos peixes transportados no segundo experimento, com 8 g de sal/L de água, não foi verificada mudança significativa no cortisol plasmático, mas a glicose aumentou significativamente em todas as densidades após o transporte, retornando para níveis normais em 24 horas. Houve mortalidade de 11% em uma das repetições da densidade de 200 kg/m³ de água. Para o transporte com 8 g de sal/L de água, a densidade máxima deve ser de 150 kg/m³ de água. Nesta densidade os parâmetros físico-químicos de qualidade de água se mantêm com características adequadas, as respostas ao estresse são mínimas e não há mortalidade.

Procesos electrolíticos industriales. Electrolisis de la sal NaCl en disolución acuosa y como sal fundida.

OpenAIRE

Milla González, Miguel

2014-01-01

Se explica en este ejercicio de electroquímica los procesos correspondientes a la electrolisis de una disolución de cloruro de sodio para obtener cloro, hidrógeno y disolución de hidróxido sódico y la electrolisis de esta misma sal a la temperatura de fusión (electrolisis de sales fundidas) en presencia de cloruro de calcio. Esta última es la base para la obtención industrial de sodio metal y de gas cloro. Mediante animaciones se explican ambos procesos electrolíticos. Asimismo se justifican ...

Saul Bellow’s Response to Nietzsche’s Ideas on Nihilism in The Victim

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Sima Farshid

2012-09-01

Full Text Available This paper intends to expound Saul Bellow’s response to Nietzsche’s ideas on nihilism. The latter contends that the life-denying morality of Christianity has ultimately resulted in modern nihilism to solve which he propounds “active nihilism”. While “passive nihilism”, he argues, has darkened human life, the active one can save modern human, because it enables them to go beyond infertile moral judgments. In his second novel The Victim (1947 which portrays human anxieties in the modern era, Bellow comparatively asks his readers to confront nihilism, instead of ignoring it, and then make efforts to prevail over it, nevertheless the path he suggests differs from the one offered by Nietzsche. He depicts modern human’s predicament in The Victim by posing its central character in a disheartening situation, but concurrently shows his perturbed endeavors to discern a way to surmount that situation. Eventually he realizes that to divest himself out of that quandary, he must overcome his fear of death to salute life, and also to acknowledge the bond of human beings that creates in them a sense of responsibility toward each other. It is here that Bellow parts with Nietzsche who holds that elevation is only gained by the egotistic Overman.

Litter decomposing fungi in sal (Shorea robusta forests of central India

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RAM KEERTI VERMA

2011-11-01

Full Text Available Soni KK, Pyasi A, Verma RK. 2011. Litter decomposing fungi in sal (Shorea robusta forests of central India. Nusantara Bioscience 3: 136-144. The present study aim on isolation and identification of fungi associated with decomposition of litter of sal forest in central India. Season wise successional changes in litter mycoflora were determined for four main seasons of the year namely, March-May, June-August, September-November and December-February. Fungi like Aspergillus flavus, A. niger and Rhizopus stolonifer were associated with litter decomposition throughout the year, while Aspergillus fumigatus, Cladosporium cladosporioides, C. oxysporum, Curvularia indica, and C. lunata were recorded in three seasons. Some fungi including ectomycorrhiza forming occur only in the rainy season (June-August these are Astraeus hygrometricus, Boletus fallax, Calvatia elata, Colletotrichum dematium, Corticium rolfsii, Mycena roseus, Periconia minutissima, Russula emetica, Scleroderma bovista, S. geaster, S. verrucosum, Scopulariopsis alba and four sterile fungi. Fungi like Alternaria citri, Gleocladium virens, Helicosporium phragmitis and Pithomyces cortarum were rarely recorded only in one season.

Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis

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Mesfin Yimam

2016-01-01

Full Text Available Some botanicals have been reported to possess antioxidative activities acting as scavengers of free radicals rendering their usage in herbal medicine. Here we describe the potential use of “SAL,” a standardized blend comprised of three extracts from Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis, in mitigating chemically induced acute liver toxicities. Acetaminophen and carbon tetrachloride induced acute liver toxicity models in mice were utilized. Hepatic functional tests from serum collected at T24 and hepatic glutathione and superoxide dismutases from liver homogenates were evaluated. Histopathology analysis and merit of blending 3 standardized extracts were also confirmed. Statistically significant and dose-correlated inhibitions in serum ALT ranging from 52.5% (p=0.004 to 34.6% (p=0.05 in the APAP and 46.3% (p<0.001 to 29.9% (p=0.02 in the CCl4 models were observed for SAL administered at doses of 400–250 mg/kg. Moreover, SAL resulted in up to 60.6% and 80.2% reductions in serums AST and bile acid, respectively. The composition replenished depleted hepatic glutathione in association with an increase of hepatic superoxide dismutase. Unexpected synergistic protection from liver damage was also observed. Therefore, the composition SAL could be potentially utilized as an effective hepatic-detoxification agent for the protection from liver damage.

Exploration of Shorea robusta (Sal seeds, kernels and its oil

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Shashi Kumar C.

2016-12-01

Full Text Available Physical, mechanical, and chemical properties of Shorea robusta seed with wing, seed without wing, and kernel were investigated in the present work. The physico-chemical composition of sal oil was also analyzed. The physico-mechanical properties and proximate composition of seed with wing, seed without wing, and kernel at three moisture contents of 9.50% (w.b, 9.54% (w.b, and 12.14% (w.b, respectively, were studied. The results show that the moisture content of the kernel was highest as compared to seed with wing and seed without wing. The sphericity of the kernel was closer to that of a sphere as compared to seed with wing and seed without wing. The hardness of the seed with wing (32.32, N/mm and seed without wing (42.49, N/mm was lower than the kernels (72.14, N/mm. The proximate composition such as moisture, protein, carbohydrates, oil, crude fiber, and ash content were also determined. The kernel (30.20%, w/w contains higher oil percentage as compared to seed with wing and seed without wing. The scientific data from this work are important for designing of equipment and processes for post-harvest value addition of sal seeds.

Kuidas Helena Bonham Carter ahviks muutus

Index Scriptorium Estoniae

2001-01-01

Taas on ekraanile jõudnud "Ahvide planeet" ("Planet of the Apes") : režissöör Tim Burton : Ameerika Ühendriigid 2001. Kuidas tehti näitlejatele ahvide grimmi. Lähemalt Helena Bonham Carteri grimmist

Imagens apesar de tudo: problemas e polêmicas em torno da representação, de Shoah a O filho de Saul

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Ilana Feldman

Full Text Available Resumo Este artigo pretende investigar as polêmicas e os problemas em torno da representação do Holocausto (Shoah, a partir de três ensaios de Georges Didi-Huberman, Images malgré tout (2003, "Cascas" (2013 e Sortir du noir (2015. Tais textos se endereçam ao “inimaginável” e ao “irrepresentável”, filosófico e estético, e o refutam, por meio da análise de quatro fotografias, capturadas por membros do Sonderkommando em Auschwitz-Birkenau em agosto de 1944. Em cotejo com o cinema, de Shoah a O filho de Saul, passando por Noite e neblina e Kapo, atualizamos a querela das imagens, cada vez mais atual e longe de ser encerrada.

Memory, Art and Mourning: the Case of the 'Salón del Nunca Más' of Granada (Antioquia, Colombia

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Elkin Rubiano Pinilla

2017-07-01

Full Text Available This document examines the work produced in the 'Salón del Nunca Más', located in Granada (Antioquia on the subject of collective memory. In this rural town, the 'Salón' has articulated different practices that, along with the construction of memory, have allowed survivors of violence and family members of killed and disappeared individuals to symbolize loss by means of public rituals. On the other hand, the article explores the visual settings that lay down the event, not only the exposure of violent events but the practices of the local community: what happens in the 'Salón', the journalistic covering (written press, the documental photography (Jesús Abad Colorado and the artistic work (Erika Diettes. For this purpose, archival material, a historical interdisciplinary approach, psychoanalysis and image and communication theories, as well as interviews is referenced through this article.

Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge.

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Lucilene Aparecida Resende

Full Text Available Dogs represent the most important domestic reservoir of L. chagasi (syn. L. infantum. A vaccine against canine visceral leishmaniasis (CVL would be an important tool for decreasing the anxiety related to possible L. chagasi infection and for controlling human visceral leishmaniasis (VL. Because the sand fly salivary proteins are potent immunogens obligatorily co-deposited during transmission of Leishmania parasites, their inclusion in an anti-Leishmania vaccine has been investigated in past decades. We investigated the immunogenicity of the "LbSapSal" vaccine (L. braziliensis antigens, saponin as adjuvant, and Lutzomyia longipalpis salivary gland extract in dogs at baseline (T0, during the post-vaccination protocol (T3rd and after early (T90 and late (T885 times following L. chagasi-challenge. Our major data indicated that immunization with "LbSapSal" is able to induce biomarkers characterized by enhanced amounts of type I (tumor necrosis factor [TNF]-α, interleukin [IL]-12, interferon [IFN]-γ cytokines and reduction in type II cytokines (IL-4 and TGF-β, even after experimental challenge. The establishment of a prominent pro-inflammatory immune response after "LbSapSal" immunization supported the increased levels of nitric oxide production, favoring a reduction in spleen parasitism (78.9% and indicating long-lasting protection against L. chagasi infection. In conclusion, these results confirmed the hypothesis that the "LbSapSal" vaccination is a potential tool to control the Leishmania chagasi infection.

Reducing salt intake to prevent hypertension and cardiovascular disease Reducción del consumo de sal para prevenir la hipertensión y las enfermedades cardiovasculares

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Feng J. He

2012-10-01

Full Text Available There is compelling evidence that dietary salt intake is the major cause of raised blood pressure (BP and that a reduction in salt intake from the current level of ≈ 9 - 12 g/day in most countries to the recommended level of 9 g/day is highly prevalent. Sources of salt in the diet vary hugely among countries; in developed countries, 75% of salt comes from processed foods, whereas in developing countries such as parts of Brazil, 70% comes from salt added during cooking or at the table. To reduce population salt intake, the food industry needs to implement a gradual and sustained reduction in the amount of salt added to foods in developed countries. In developing countries, a public health campaign plays a more important role in encouraging consumers to use less salt coupled with widespread replacement of salt with substitutes that are low in sodium and high in potassium. Numerous countries in the Americas have started salt reduction programs. The challenge now is to engage other countries. A reduction in population salt intake will result in a major improvement in public health along with major health-related cost savings.Hay datos probatorios irrefutables de que la ingesta de sal alimentaria es la principal causa de hipertensión y de que una reducción del consumo de sal, del nivel actual de aproximadamente 9 a 12 g/d en la mayor parte de los países al nivel recomendado de menos de 5 g/d, disminuye la presión arterial. Una reducción adicional hasta 3 a 4 g/d tiene un mayor efecto y es necesario seguir teniendo en cuenta la posibilidad de metas de consumo de sal inferiores en la población. Los estudios de cohortes y los ensayos clínicos han demostrado que el menor consumo de sal se asocia con una reducción del riesgo de padecer enfermedades cardiovasculares. La reducción de sal es una de las medidas más rentables para mejorar la salud pública a escala mundial. En la Región de las Américas, hay una alta prevalencia de un consumo de

Feasibility of salt reduction in processed foods in Argentina Factibilidad de reducir el contenido de sal de los alimentos procesados en la Argentina

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Daniel Ferrante

2011-02-01

Full Text Available OBJECTIVE: To assess an intervention to reduce salt intake based on an agreement with the food industry. METHODS: Salt content was measured in bakery products through a national survey and biochemical analyses. Low-salt bread was evaluated by a panel of taste testers to determine whether a reduced salt bread could remain undetected. French bread accounts for 25% of the total salt intake in Argentina; hence, reducing its salt concentration from 2% to 1.4% was proposed and tested. A crossover trial was conducted to evaluate the reduction in urinary sodium and blood pressure in participants during consumption of the low-salt bread compared with ordinary bread. RESULTS: Average salt content in bread was 2%. This study evaluated low-salt bread containing 1.4% salt. This reduction remained mostly undetected by the panels of taste testers. In the crossover trial, which included 58 participants, a reduction of 25 milliequivalents in 24hour urine sodium excretion, a reduction in systolic blood pressure of 1.66 mmHg, and a reduction in diastolic blood pressure of 0.76 mmHg were found during the low-salt bread intake. CONCLUSIONS: The study showed that dietary salt reduction was feasible and well accepted in the population studied through a reduction of salt content in bread. Although the effects on urinary sodium and blood pressure were moderate, a countrywide intervention could have a greater public health impact.OBJETIVO: Evaluar una intervención destinada a reducir el consumo de sal a partir de un convenio con la industria alimentaria. MÉTODOS: Se midió el contenido de sal de los productos de panadería por medio de una encuesta nacional y análisis bioquímicos. Un grupo de catadores evaluó el pan con bajo contenido de sal para determinar si la disminución pasaba inadvertida. Dado que el pan francés representa 25% del consumo total de sal en la Argentina, se propuso someter a prueba este tipo de pan con una disminución de la concentración de

Toxicidade aguda ao sal comum e larvicultura intensiva do jundiá Rhamdia quelen em água salobra

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T.E.H.P. Fabregat

2015-04-01

Full Text Available A tolerância de peixes de água doce à salinidade e os níveis adequados de náuplios de Artemia na alimentação durante a larvicultura são de extrema importância para a padronização dos manejos em ambientes de criação intensiva. Dessa forma, o objetivo do trabalho foi estimar a salinidade letal (SL50 para larvas de jundiá Rhamdia quelen e determinar o efeito da salinidade e da concentração de presas vivas na larvicultura intensiva. No primeiro ensaio, larvas ao final do período lecitotrófico (1,1±0,8mg foram submetidas às salinidades de 0, 2, 4, 6, 8, 10, 15 e 20g de sal/L por um período de 96h. No segundo experimento, as larvas de jundiá, no início da alimentação exógena (1,2±0,3mg, foram submetidas a três salinidades (água doce 0, 2 e 4g de sal/L e três concentrações de presas vivas (início: 300, 500, 700 náuplios de Artemia/larvas/dia, sendo esse montante aumentado a cada cinco dias. O experimento foi realizado em delineamento inteiramente ao acaso, em esquema fatorial 3x3, por um período de 15 dias. No experimento 1, as larvas de jundiá submetidas às salinidades de 10, 15 e 20g de sal/L morreram após 12, duas e uma hora de exposição, respectivamente. As SL50 de 72 e 96h foram estimadas em 9,93 e 4,95g de sal/L, respectivamente. No final do teste de toxicidade, não houve diferença na sobrevivência entre as salinidades de 0, 2 e 4g de sal/L. No experimento 2, não foi observado efeito da interação entre salinidade e concentração de presas para o peso e o comprimento. Quanto maior a quantidade de presas, maior o crescimento das larvas. A sobrevivência apresentou interação entre os fatores. O aumento da salinidade proporcionou uma diminuição da sobrevivência, independentemente da concentração de presas. Dessa forma, conclui-se que a SL50 diminuiu com o aumento do tempo de exposição à água salinizada e que a larvicultura da espécie pode ser realizada em salinidades de até 2g de sal/L, com

Contenido de yodo en sal a nivel de puestos de venta provenientes de distintas localidades en tres regiones argentinas

OpenAIRE

López Linares, S; Heer I, Martín

2014-01-01

Introducción: La deficiencia de yodo es la principal causa prevenible de retardo mental y daño cerebral en la población. La yodación de la sal en Argentina es obligatoria según Ley 17259/67. El objetivo fue determinar el contenido de yodo en sal obtenida de puestos de venta de distintas localidades de provincias que integran la región del noroeste (NOA), nordeste (NEA) y Cuyo. Material y métodos: Estudio descriptivo y transversal. Se analizaron 80 sales adquiridas por compra directa, mercado ...

Rutas de circulación e intercambio de sal en la provincia de Tunja, segunda mitad del siglo XVI

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Blanca Ofelia Acuña Rodriguez

2018-02-01

Full Text Available A través de este texto se pretende dar a conocer cómo las rutas de circulación de sal en la Provincia de Tunja contribuyeron a configurar un gran espacio económico, que integró a las provincias de Santa Fe, Pamplona y Tunja en el Nuevo Reino de Granada, durante el siglo XVI. Se partió de una reflexión historiográfica relacionada con la circulación y el comercio de la sal, los medios de transporte y las rutas usadas por los indígenas y los españoles; a partir de las cuales se consolidó un espacio económico mediado por la producción y distribución de la sal, que convirtió a la provincia de Tunja en un eje articulador de relaciones entre los sitios productores de sal en la provincia de Santa Fe y los consumidores de las provincias de Tunja y Pamplona. Esta articulación regional facilitó tanto la circulación de productos de distintos pisos térmicos, como la integración de un amplio territorio colonial. Esto debido a que la localización de Tunja como lugar de paso y conexión entre las Provincias de Santafé, Pamplona y los Llanos de San Juan, hizo de esta ciudad y sus términos un atractivo para el asentamiento hispano, a la vez que generó, durante la segunda mitad del siglo XVI, la posibilidad para que se organizaran en toda la Provincia de Tunja, sitios de aposento, venta y reventa de productos importados de España y productos de la tierra, para el sustento y abastecimiento de las necesidades básicas, y de esta forma sacar provecho de las producciones locales como la sal, el hayo, el algodón, las mantas y otros productos.

Pré-Sal: Petróleo e políticas públicas no Brasil (2007-2016

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Paulo Henrique Martinez

2016-06-01

Full Text Available O artigo analisa a relação entre políticas sociais e economia no Brasil a partir da exploração do Pré-sal até os dias de hoje. O anúncio das reservas de petróleo na camada de Pré-sal resultou em rápidas alterações nas perspectivas econômicas, sociais e legais do país nas primeiras duas décadas do século XXI. A nova escala da produção petrolífera nacional seria a base para uma agenda de desenvolvimento econômico e social nos governos dos presidentes Lula e Dilma. Em seus respectivos governos ambos promoveram reformulações no marco regulatório do petróleo. A legislação foi alterada no tocante aos modelos de contrato, a distribuição dos royalties e o controle das reservas, assegurando ao Governo Federal maior soberania na extração, refino e distribuição do petróleo. As modificações legislativas e políticas visavam à destinação de parte dos lucros do Pré-sal para investimentos em infraestrutura e para políticas setoriais de desenvolvimento humano no Brasil.

O salário na obra de Frederick Winslow Taylor Frederick Winslow Taylor's oeuvre: an analysis of wages

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Victor Paulo Gomes da Silva

2011-08-01

Full Text Available O presente artigo analisa e explica a perspectiva de Frederick Winslow Taylor sobre o salário, tal como enunciada em suas duas grandes obras: Shop management (1903 e Principles of scientific management (1911. A primeira parte consubstancia-se na apresentação de aspectos econômicos relevantes que caracterizaram o tempo em que ele viveu e o quanto influenciaram suas obras. Na segunda parte, é efetuada uma análise da forma como o salário é apresentado nas duas obras de F. W. Taylor. O artigo termina com um comentário sobre as obras supracitadas no que se refere à perspectiva taylorista do salário.This paper analyses and explains Frederick Winslow Taylor's perspective on wages, as it is presented in his main literary works: Shop management (1903 and Principles of scientific management (1911. The first part presents the main economic aspects that characterized his lifetime, which undoubtedly influenced his literary works. The second part analyses F. W. Taylor's two main books in which the author's perspective about wages is discussed. The paper concludes with a critical view of F. W. Taylor's view on wages.

Een onwrikbaar geloof in zijn gelijk : Sal Tas (1905-1976): journalist van de wereld

NARCIS (Netherlands)

de Vries, Tity

Biography of the Dutch Sal Tas, activist, political writer and reporter/foreign correspondent in Paris of the newspaper Het Parool and the American non-communist left journal The New Leader during the 1950s. Tas was a controversial man with outspoken opinions. Radical left in his young years, later

Changements climatiques et infiltrations d'eau salée le long du ...

International Development Research Centre (IDRC) Digital Library (Canada)

La Méditerranée orientale est très exposée aux infiltrations d'eau salée dans les aquifères (qui contiennent de l'eau douce) se trouvant sur son littoral. La dégradation des aquifères pourrait entraîner de graves conséquences socioéconomiques pour les personnes qui vivent en ces lieux. Le projet consistera à étudier ...

Validación del método Potenciométrico por Ión Selectivo para la determinación de Flúor en sal, agua y orina

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Patricia Aguilar R

2001-01-01

Full Text Available Objetivo: Validar el método potenciómetro por ión selectivo en la determinación de fluoruro. Materiales y métodos: Se analizaron 3 tipos de muestras (sal, agua, y orina, trabajándose con 3 analistas para el agua y sal, y 2 para la orina. La validación se realizó en 2 días, realizándose 10 ensayos por día. Se calculó la precisión (en condiciones de repetibilidad y reproducibilidad y exactitud del método (en términos de recuperación del analito adicionado a la muestra. Resultados: Se obtuvo una desviación estándar relativa (RSD de 2.68%, 3.29% y 2.52% en sal, agua y orina, respectivamente, y se logró recuperar 98.20%, 99.42% y 98.11 % del analito en las mismas muestras de sal, agua y orina, respectivamente. Conclusión: El método potenciómetro, por ión selectivo, realizado en condiciones óptimas y apropiadas, puede aplicarse para la determinación de flúor en muestras de sal, agua y orina.

Economic contribution of participatory agroforestry program to poverty alleviation: a case from Sal forests, Bangladesh

NARCIS (Netherlands)

Islam, K.K.; Hoogstra, M.A.; Ullah, M.O.; Sato, N.

2012-01-01

In the Forest Department of Bangladesh, a Participatory Agroforestry Program (PAP) was initiated at a denuded Sal forests area to protect the forest resources and to alleviate poverty amongst the local poor population. We explored whether the PAP reduced poverty and what factors might be responsible

Mobility Analysis of the Population of Rabat-Salé-Zemmour-Zaer

OpenAIRE

F. Ghaiti

2007-01-01

In this paper, we present the 2006 survey study origin destination and price that we carried out during 2006 fall in the area in the Moroccan region of Rabat-Salé-Zemmour-Zaer. The survey concerns the people-s characteristics, their displacements behavior and the price that they will be able to pay for a tramway ticket. The main objective is to study a set of relative features to the households and to their displacement's habits and to their choices among public and privet transport modes. A ...

An Experiment to Study Sporadic Atom Layers in the Earth's Mesosphere and Lower Thermosphere (SAL)

Science.gov (United States)

Kelley, Michael C.

1999-01-01

The Sudden Atom Layer (SAL) Rocket was successfully launched in February 1998. All instruments worked well except those supplied by NASA Goddard Space Flight Center. (A dummy weight was launched for the neutral mass spectrometer and the ion version died shortly after lift-off.) A paper has already been published in GRL concerning the dust layer detected by an on board instrument and compared to ground-based observations made at the Arecibo Observatory by Cornell graduate student S. Collins (lidar) and Q. Zhou (radar). Collins presented a comparison of the sodium lidar data and onboard observations with a theoretical model by Plane and Cox at the Fan AGU Meeting. In addition Gelinas and Kelley presented a review paper dealing with the entire SAL instrument complement at the same meeting. An unexpected new explanation for the outer scale of E region plasma irregularities has come out of the data set. We anticipate at least a total of four papers will be published within a year of launch.

Novel acyloxy derivatives of branched mono- and polyol esters of sal fat: multiviscosity grade lubricant base stocks.

Science.gov (United States)

Kamalakar, Kotte; Sai Manoj, Gorantla N V T; Prasad, Rachapudi B N; Karuna, Mallampalli S L

2014-12-10

Sal fat, a nontraditional seed oil, was chemically modified to obtain base stocks with a wide range of specifications that can replace mineral oil base stocks. Sal fatty acids were enriched to 72.6% unsaturation using urea adduct method and reacted with branched mono alcohol, 2-ethylhexanol (2-EtH), and polyols namely neopentyl glycol (NPG) and trimethylolpropane (TMP) to obtain corresponding esters. The esters were hydroxylated and then acylated using propionic, butyric, and hexanoic anhydrides to obtain corresponding acylated derivatives. The acylated TMP esters exhibited very high viscosities (427.35-471.93 cSt at 40 °C) similar to those of BS 150 mineral oil base stock range, ISO VG 460, while the acylated NPG esters (268.81-318.84 cSt at 40 °C) and 2-EtH esters viscosities (20.94-24.44 cSt at 40 °C) exhibited viscosities in the range of ISO VG 320 and 22 respectively with good viscosity indices. Acylated NPG esters were found suitable for high temperature and acylated 2-ethylhexyl esters for low viscosity grade industrial applications. It was observed that the thermo-oxidative stabilities of all acylated products were found better compared to other vegetable oil based base stocks. Overall, all the sal fat based lubricant base stocks are promising candidates with a wide range of properties, which can replace most of the mineral oil base stocks with appropriate formulations.

Determinantes da satisfação e atributos da qualidade em serviços de salão de beleza

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José Luis Duarte Ribeiro

2013-09-01

Full Text Available Este artigo apresenta um modelo de representação dos determinantes da satisfação dos clientes de serviços em salões de beleza e dos atributos de qualidade percebidos por eles. Para isso, foram aplicadas duas pesquisas junto a usuários de salões de beleza com a finalidade de: (i determinar as relações entre os determinantes da satisfação dos clientes; e (ii identificar e hierarquizar atributos de qualidade percebidos, de acordo com sua importância para os clientes do serviço em questão. A confirmação de expectativas e a qualidade percebida aparecem como os principais determinantes da satisfação dos clientes. Competência técnica, limpeza do ambiente e dos utensílios, cumprimento de horários e localização conveniente aparecem como os principais atributos de qualidade percebidos. Os resultados desta pesquisa podem ser usados pelos gerentes de salões de beleza para aprimorar a qualidade do serviço e a satisfação dos clientes, estabelecendo um diferencial competitivo para sua empresa.

Domates Pulpu ve Salçasında Viskozite (Konsistens ve Renk Üzerine Proses Koşullarının Etkisi

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Aziz Ekşi

2015-02-01

Full Text Available Kıvam ve renk, domates pulpu ve salçada kaliteyi belirleyen ve ticarette üzerinde en çok durulan iki önemli etkendir. Domates salçasında renk ve kıvam ile hammaddenin durumu arasında yakın bir ilişki bulunduğu bilinmektedir. Ancak her iki kalite öğesini ve özellikle kıvamı, hammadde olduğu kadar, proses koşulları da etkilemektedir.

A formação dos salários nos setores público e privado

OpenAIRE

Marconi, Nelson

2010-01-01

Este trabalho visa comprovar a existência de segmentação entre os mercados de trabalho público e privado, evidenciada através dos diferenciais salariais e das distintas regras de formação de salários em ambos, buscando discutir de modo mais detalhado quais seriam estas regras no setor público.

ELABORAÇÃO DE PÃO DE SAL UTILIZANDO FARINHA MISTA DE TRIGO E LINHAÇA

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T. M. OLIVEIRA

2008-11-01

Full Text Available

A linhaça (Linum usitatissimum L. é uma semente que possui compostos fisiologicamente ativos, sendo fonte de fibras, ômega-3 e lignanas. Seu consumo vem sendo associado à prevenção de algumas doenças e a benefícios nutricionais. O objetivo desse trabalho foi testar a viabilidade de utilização de uma farinha mista, composta de trigo e linhaça na produção de pão de sal através da avaliação das características físico-químicas, sensoriais e tecnológicas do pão. Testes preliminares de farinografia, extensografia e panificação experimental foram realizados para determinaçãoda melhor formulação, que foi utilizada para produção do pão em uma panificadora comercial. Esse pão foi avaliado quanto a características físico-químicas, sensoriais e de textura. A adição de farinha de linhaça ao pão de sal na proporção de 10% mostrou ser viável tecnicamente, com uma excelente aceitação pelos consumidores, sabor agradável e características físico-químicas similares ao pão de sal tradicional, representando uma opção mais nutritiva e saborosa para a alimentação diária de vários consumidores.

Apmierinātības ar dzīvi saistība ar sociālo salīdzināšanu.

OpenAIRE

Tamsone, Liliāna

2011-01-01

Šajā bakalaura darbā tika izvirzīti trīs pētījuma jautājumi: 1)Kāda saistība pastāv starp apmierinātību ar dzīvi un sociālās salīdzināšanas līmeni? 2)Kāda saistība pastāv starp apmierinātību ar dzīvi un augšupejošo salīdzināšanu? 3)Kāda saistība pastāv starp apmierinātību ar dzīvi un lejupejošo salīdzināšanu? Pētījumā piedalījās 58 respondenti – 12 vīrieši un 46 sievietes vecumā no 25 līdz 45 gadiem. Respondentu vidējais vecums ir M = 31,67, SD = 5,11. Pētījuma instrumentārijs iekļauj divas m...

Observaciones histopatologicas de juveniles penaeus vannamei sometidos a dietas artificiales con diferentes concentraciones de una sal de ácido ascórbico (vitamina c)

OpenAIRE

Vera Muñoz, L.

1995-01-01

Observaciones histopatologicas de juveniles Penaeus Vannamei sometidos a dietas artificiales con diferentes concentraciones de una sal de ácido ascórbico (vitamina C) Se realizaron análisis histológicos y comprobación mediante métodos histoquímicos de la presencia de melanina, a juveniles Penaeus vannamei sometidos a cinco dietas experimentales con diferentes concentraciones de una sal de L-Ascorbato-2-Fosfato de Mg (APM) usada como fuente de ácido ascórbico (AA).

Avances en la reducción del consumo de sal y sodio en Costa Rica Advances in reducing salt and sodium intake in Costa Rica

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Adriana Blanco-Metzler

2012-10-01

Full Text Available En el presente artículo se describen los avances logrados en Costa Rica -así como los desafíos y limitaciones- en la reducción del consumo de sal. El establecimiento del Plan Nacional para la Reducción del Consumo de Sal/sodio en la Población de Costa Rica 2011 - 2021 se complementó con programas y proyectos multisectoriales específicos dirigidos a: 1 conocer la ingesta de sodio y el contenido de sal o sodio en los alimentos de mayor consumo; identificar los conocimientos, actitudes y comportamientos del consumidor respecto a la sal/sodio, su relación con la salud y el etiquetado nutricio-nal; evaluar la relación costo-efectividad de las medidas dirigidas a reducir la prevalencia de hipertensión arterial; 2 implementar estrategias para disminuir el contenido de sal/sodio en los alimentos procesados y los preparados en casa; 3 promover cambios de conducta en la población para reducir el consumo de sal en la alimentación; y 4 monitorear y evaluar las acciones dirigidas a reducir el consumo de sal o sodio en la población. Para alcanzar las metas propuestas se debe lograr una exitosa coordinación interinstitucional con los actores estratégicos, negociar compromisos con la industria alimentaria y los servicios de alimentación, y mejorar la regulación de los nutrientes críticos asociados con las enfermedades crónicas no transmisibles, en los alimentos. Se espera que a partir de los avances logrados durante la ejecución del Plan Nacional, Costa Rica logre alcanzar la meta internacional de reducción del consumo de sal.This article describes the progress-as well as the challenges and limitations-in reducing salt intake in Costa Rica. The National Plan to Reduce Public Consumption of Salt/Sodium in Costa Rica 2011 - 2021 was complemented with multisectoral programs and projects specifically designed to: 1 determine sodium intake and the salt/sodium content of the most widely consumed foods; identify the consumer knowledge, attitudes

Hinduism’s Four Stages of Life in Saul Bellow’s Henderson the Rain King

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Manimangai Mani

2016-07-01

Full Text Available The oldest of Hindu’s philosophical writings, the Rig Veda, which came to being about 4500 BC underlined that, the cause of all misery that befalls  mankind  is his/her desire; or more promptly said, his/her attachment to the desire. In Hinduism, this physical plane is just a stage with life itself is nothing more than a play. The stage is set in such a way to enable the souls which took the human form to evolve and to find the enlightenment and ultimately to become one with the creator. All the material elements including the complex relationship found in this plane is nothing but a mere illusion. This study aims to explore elements of Hindu philosophy in Saul Bellow’s novel, Henderson the Rain King (1976. Eugene Henderson, the main character in this novel is portrayed as drowning in the materialistic world. Being constantly mugged by a desirable voice within him whispering, I want, I want, it is not an irony if he generated a sense of uselessness and emptiness. This study shows how Henderson’s decision to go to Africa to find the meaning of life coincides with the Hindu philosophy of the four stages of life; Brahmacharya (celibacy, Grahasthya (householdership, Vanaprastha (detachment in attachment and Sanyas (seclusion.  Henderson comes to realization in his third stage and proceeds to the fourth stage. Henderson is taught to eradicate fear and to break the cycle of desire. Towards the end, Henderson realises that the voice was actually referring to, “He wants, She wants and They want”. The voice was actually echoing the desires of mankind.

76 FR 9403 - Finding That the Lebanese Canadian Bank SAL Is a Financial Institution of Primary Money...

Science.gov (United States)

2011-02-17

... Bank SAL Is a Financial Institution of Primary Money Laundering Concern AGENCY: Financial Crimes...'') is a financial institution of primary money laundering concern. DATES: The finding made in this... Law 107-56. Title III of the USA PATRIOT Act amended the anti- money laundering provisions of the Bank...

Diabetes gestacional, hipotiroidismo y concentración urinaria de yodo en embarazadas. Yodurias en escolares en Paraguay: Exceso de yodo en la sal y riesgo de hiper e hipotiroidismo

OpenAIRE

Jara Yorg, Jorge Antonio; Pretell, Eduardo A; Ovelar, Elsi; Sánchez Bernal, S; Mendoza, L; Jara Mark, A; Jara Ruiz, Jessica M; Jara Ruiz, Elías; Ortellado, José; Acuña, Vicente; Brizuela, Félix; Rodriguez, Amada; Santos, Jorge; Peña, Giuliana; Arevalos, Cecilia

2016-01-01

El principal indicador del impacto de la yodación de la sal de consumo humano es la concentración urinaria de yodo la cual es útil en el monitoreo de la sal. En la encuesta del año 1988 realizada en el Paraguay, se alcanzó una prevalencia de bocio de 48,6% en la población escolar con un déficit de yodo en la sal, pero el año 2000 en el estudio del proyecto de Tiroides Móvil, se redujo por el método ecográfico a 17%. Ese mismo año la mediana de los niveles urinarios en niños escolares de 6-12 ...

mSalUV: un nuevo sistema de mensajería móvil para el control de la diabetes en México

OpenAIRE

Néstor Iván Cabrera Mendoza; Pedro Pablo Castro Enriquez; Verónica Patricia Demeneghi Marini; Luis Fernández Luque; Jaime Morales Romero; Luis Sainz Vazquez; María Cristina Ortiz León

2014-01-01

OBJETIVO: Diseñar y desarrollar un sistema de mensajería móvil llamado mSalUV, que permita recordar a pacientes con diabetes mellitus tipo 2 la toma de medicación y la asistencia a citas y que promueva estilos de vida saludables, así como explorar su opinión con respecto al uso del sistema. MÉTODOS: Se consideraron tres etapas: la primera incluyó el diseño y desarrollo de mSalUV. La segunda abarcó el diseño y construcción de los mensajes de texto. La tercera exploró la opinión de los usuarios...

An effective parameter optimization technique for vibration flow field characterization of PP melts via LS-SVM combined with SALS in an electromagnetism dynamic extruder

Science.gov (United States)

Xian, Guangming

2018-03-01

A method for predicting the optimal vibration field parameters by least square support vector machine (LS-SVM) is presented in this paper. One convenient and commonly used technique for characterizing the the vibration flow field of polymer melts films is small angle light scattering (SALS) in a visualized slit die of the electromagnetism dynamic extruder. The optimal value of vibration vibration frequency, vibration amplitude, and the maximum light intensity projection area can be obtained by using LS-SVM for prediction. For illustrating this method and show its validity, the flowing material is used with polypropylene (PP) and fifteen samples are tested at the rotation speed of screw at 36rpm. This paper first describes the apparatus of SALS to perform the experiments, then gives the theoretical basis of this new method, and detail the experimental results for parameter prediction of vibration flow field. It is demonstrated that it is possible to use the method of SALS and obtain detailed information on optimal parameter of vibration flow field of PP melts by LS-SVM.

Concentraciones de yodo en orina y en sal de consumo en mujeres entre 12 a 49 años del Perú

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Carolina Tarqui-Mamani

Full Text Available Objetivos. Determinar las concentraciones de yodo en orina y sal de consumo en mujeres entre 12 a 49 años en Perú. Materiales y métodos. Se realizó un estudio observacional y transversal. Durante el 2012 y 2013, se incluyó mujeres entre 12 a 49 años residentes en los hogares peruanos seleccionadas mediante un muestreo probabilístico, estratificado y multietápico. La determinación de yodo en orina se realizó por espectrofotometría basada en la reacción de Sandell-Kolthoff. La evaluación cualitativa de yodo en sal se realizó por yoditest y la cuantitativa por volumetría. El procesamiento se realizó mediante muestras complejas con ponderaciones. Se obtuvo medianas, rango intercuartílico y percentiles. Resultados. La mediana de yoduria en las participantes fue 250,4 ug/L; los departamentos con medianas de yoduria elevadas fueron: Moquegua (389,3 ug/L; Tacna (320,5 ug/L; Madre de Dios (319,8 ug/L, y Ucayali (306,0 ug/L; mientras que Puno (192,9 ug/L; Piura (188,1 ug/L y Tumbes (180,5 ug/L tuvieron medianas dentro de lo recomendado por la OMS. La mediana de yoduria en gestantes fue 274,6 ug/L (RIQ: 283 ug/L. El 82,5% de las muestras de sal tuvieron yodo ≥30 ppm y 1,9% tuvo valores de 0 ppm. Conclusiones. La mediana de yoduria en las mujeres peruanas está por encima de lo recomendado por la OMS y la mayoría de las muestras de sal tuvieron concentraciones adecuadas de yodo según la OMS

Tsunami vulnerability and damage assessment in the coastal area of Rabat and Salé, Morocco

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A. Atillah

2011-12-01

Full Text Available This study, a companion paper to Renou et al. (2011, focuses on the application of a GIS-based method to assess building vulnerability and damage in the event of a tsunami affecting the coastal area of Rabat and Salé, Morocco. This approach, designed within the framework of the European SCHEMA project (www.schemaproject.org is based on the combination of hazard results from numerical modelling of the worst case tsunami scenario (inundation depth based on the historical Lisbon earthquake of 1755 and the Portugal earthquake of 1969, together with vulnerability building types derived from Earth Observation data, field surveys and GIS data. The risk is then evaluated for this highly concentrated population area characterized by the implementation of a vast project of residential and touristic buildings within the flat area of the Bouregreg Valley separating the cities of Rabat and Salé. A GIS tool is used to derive building damage maps by crossing layers of inundation levels and building vulnerability. The inferred damage maps serve as a base for elaborating evacuation plans with appropriate rescue and relief processes and to prepare and consider appropriate measures to prevent the induced tsunami risk.

Stakeholder perceptions of decision-making process on marine biodiversity conservation on sal island (Cape Verde

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Jorge Ramos

2011-01-01

Full Text Available In the Sal Island (Cape Verde there is a growing involvement, will and investment in the creation of tourism synergies. However, much of the economic potential of the island can be found submerged in the sea: it is its intrinsic 'biodiversity'. Due to this fact, and in order to balance environmental safety and human pressure, it has been developed a strategy addressing both diving and fishing purposes. That strategy includes the deployment of several artificial reefs (ARs around the island. In order to allocate demand for diving and fishing purposes, we have developed a socio-economic research approach addressing the theme of biodiversity and reefs (both natural and artificial and collected expectations from AR users by means of an inquiry method. It is hypothesized a project where some management measures are proposed aiming marine biodiversity conservation. Using the methodology named as analytic hierarchy process (AHP it was scrutinized stakeholders' perception on the best practice for marine biodiversity conservation in the Sal Island. The results showed that to submerge obsolete structures in rocky or mixed areas have a high potential, but does not gathers consensuality. As an overall conclusion, it seems that limitation of activities is the preferred management option to consider in the future.Na Ilha do Sal (Cabo Verde existe um crescente envolvimento, vontade e investimento na criação de sinergias turísticas. Contudo, muito do potencial económico da ilha está submerso - a biodiversidade marinha. Devido a este facto, e tendo em vista promover a sustentabilidade ambiental associada ao eco-turismo, vem sendo desenvolvida uma estratégia direccionada, quer ao mergulho, quer à pesca. Esta estratégia inclui a implantação de vários recifes artificiais (RA na Baía de Santa Maria. De modo a alocar a procura para propósitos como o mergulho e a pesca, desenvolvemos um plano de pesquisa socio-económica relativo ao tema da biodiversidade

O Mercado interno na América portuguesa: "exclusivo" metropolitano do comércio colonial e os "descaminhos do sal" na Capitania de São Paulo na primeira metade do século XVIII

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Artur José Renda Vitorino

2012-12-01

Full Text Available Este artigo visa analisar as atividades mercantis de Francisco Pinheiro, mercador português de grosso trato, e seus agentes comerciais na capitania de São Paulo na primeira metade do século XVIII, com o comércio do sal, produto monopolizado pela Coroa portuguesa. Contudo, o contrato do sal ofereceu à sua agência muito mais embaraços do que um meio seguro de amealhar riquezas, pois se deparou com a concorrência ilegal dos "donos do sal" presentes na região e a interferência das Câmaras Municipais em seus negócios.

Microcrustáceos y Vibrio cholerae O1 viable no cultivable (VNC: resultados en la Cuenca del Río Salí, Tucumán, Argentina Microcrustaceans and viable but nonculturable (VNC Vibrio cholerae O1: results in the Salí River basin, Tucumán, Argentina

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Cecilia Locascio de Mitrovich

2010-01-01

Full Text Available Vibrio cholerae reside habitualmente en aguas marinas y continentales. Según las condiciones ambientales y los recursos le sean “favorables” o “desfavorables”, se generan estados viables cultivables (VC o viables no cultivables (VNC respectivamente y, bajo esta última forma sobrevive. Para abordar la problemática del cólera en la Cuenca del Río Salí (Tucumán, Argentina, se realizaron muestreos durante los años 2003-2005 donde se consideraron aspectos fisicos, químicos, biológicos y sanitarios. Para evaluar los probables reservorios del patógeno, se analizó el zooplancton del Río Salí (Canal Norte y Banda Río Salí y Río Lules. La mayor representatividad taxonómica la registraron los copépodos, especialmente Eucyclops neumani (Pesta, 1927, junto a Acanthocyclops robustus (Sars, 1863, Metacyclops sp., Paracyclops chiltoni y Notodiaptomus incompositus (Brian, 1925, además de algunos rotíferos y cladóceros como (Lecane sp., y (Brachionus sp., Moina sp. y Leydigia sp.. La frecuencia de ocurrencia fue baja y no superó el 25%. El Canal Norte fue ambiente más propicio por la riqueza específica, abundancia y constancia de la comunidad. Las variables fisicas y químicas asociadas al zooplancton coincidirían con los valores que por nuestros registros y los antecedentes, se conocen para el desarrollo del patógeno. En el período estival hubo coincidencia entre la presencia de la forma VNC de V. cholerae O1 (inmunofluorescencia con anticuerpos anti O1 y el desarrollo del zooplancton. Se observaron formas VNC sobre apéndices o estructuras de copépodos ciclopoideos y cladóceros quidóridos, reflejando probablemente afinidad con sustratos quitinosos.Vibrio cholerae habitually lives in marine and continental waters. According to "favourable" or "unfavourable" resources and environmental conditions, viable (VC or viable non-culturable (VNC states will be generated, surviving only the latter form. To address the problem of

Luminescence properties of Sm, Tb(Sal){sub 3}Phen complex in polyvinyl alcohol: an approach for white-light emission

Energy Technology Data Exchange (ETDEWEB)

Kaur, Gagandeep; Rai, S B, E-mail: sbrai49@yahoo.co.in [Laser and Spectroscopy Laboratory, Department of Physics Banaras Hindu University, Varanasi, 221005 (India)

2011-10-26

Polyvinyl alcohol polymer films doped with Sm,Tb(Sal){sub 3}Phen complexes have been synthesized using solution casting technique. An enhancement in absorption intensity is observed revealing the encapsulation of rare earth ions by salicylic acid (Sal)/1,10 phenanthroline (Phen) complex. Photoluminescence spectra of the co-doped samples were examined by varying the concentration of Tb{sup 3+} keeping concentration of Sm{sup 3+} ions fixed and vice-versa. It is found that the polymer samples emit a combination of blue, green and orange-red wavelengths tunable to white light when excited with 355 nm radiation. The emission spectra also show a self-quenching effect at higher concentration of Sm{sup 3+} ions. An efficient energy transfer was observed from Tb{sup 3+} : {sup 5}D{sub 4} {yields} Sm{sup 3+} : {sup 4}G{sub 9/2}. The reason for the enhancement in fluorescence intensities of Sm{sup 3+} in the co-doped polymer sample is the intermolecular as well as the intramolecular energy transfer.

TV REKLAMLARINDAN KAÇINMA: DAVRANIŞSAL VE MEKANİK KAÇINMAYA ETKİ EDEN FAKTÖRLER

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Ayşen AKYÜZ

2012-11-01

Full Text Available TV ADVERTISING AVOIDANCE: THE FACTORS INFLUINCING BEHAVIOURAL AND MECHANISTIC AVOIDANCEAbstract: TV advertising avoidance, presents a main issue for advertisers and marketers. Creation of TV ads involves great effort, imaginative strategy formulation and high expenditures. The expectations of the companies and advertisers from the medium are intrinsically high. The current study examines the influence of both the general attitude towards advertising and the belief factors (product information, good for economy, hedonic/pleasure and materialism on behavioral (e.g .making phone calls and mechanical avoidance (e.g. zapping by conducting surveys with the university students. Structural Equation Model is employed to investigate the relationship between the dependent and independent variables. It is believed that, the findings would make a significant contribution towards a development of the theory and create bases for a further research on this topic. Keywords: Ad Avoidance, Behavioral Avoidance, Mechanical Avoidance, Beliefs, Attitude Toward Advertising.  TV REKLAMLARINDAN KAÇINMA: DAVRANIŞSAL VE MEKANİK KAÇINMAYA ETKİ EDEN FAKTÖRLER Özet: Reklamdan kaçınma davranışı, reklamcılar ve pazarlamacılar için oldukça önemli bir gündem oluşturmaktadır. Televizyon reklamlarının yaratılması yoğun çaba, yaratıcı strateji ve yüksek harcamaları kapsar. Firmaların ve reklamcıların bu iletişim aracından beklentileri ise doğal olarak yüksek olacaktır. Bu çalışma, hem inanç faktörlerinin (bilgilendirme, ekonomik fayda, zevk/hoşnutluk, materyalizm; hem de reklama yönelik genel tutumun, davranışsal ve mekanik kaçınma üzerindeki etkilerini üniversite öğrencileri ile yapılan bir anket çalışması ile incelemektedir. Bağımlı ve bağımsız değişkenler arasındaki ilişkiyi incelemek için Yapısal Eşitlik Modeli kullanılmıştır. Bulguların hem konuyla ilgili gelecekte yapılacak araştırmalarda hem de

Tartu Ülikooli Õigusteaduskonna kogu viimase koosseisu saatusest / Artur Taska

Index Scriptorium Estoniae

Taska, Artur, 1912-1994

1989-01-01

Sisaldab andmeid Ants Piibu, D. Grimmi, I. Tjutrjumovi, Artur-Tõeleid Kliimanni, Ernst Eini, Nikolai Maimi, Mart Nurga, Jüri Uluotsa, Elmar Ilusa, H. Kadari, L. Leesmenti, Juhan Vaabeli, Richard, Räägo, Otto Liivi, Hans Ronimoisi, T. Grünthali, Veera Poska-Grünthali, Artur Mägi, F. Malmi, G. Rooksi, Valmar Adamsi, Paul Vihalema, Rein Eliaseri, A. Rammuli, H. Randalu, Edgar Talviku, A. Perandi ja Väino Langi kohta

Estudo microbiológico do sal (Cloreto de sódio de origem marinha Microbiological study of marine salt (sodium chloride

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Niber da Paz Moreira da Silva

1976-01-01

Full Text Available Foram analisadas 19 amostras de SAL (NaCl, tipo grosso, oriundas de diferentes salinas, para verificação da flora microbiana e presença de bactérias nocivas em Microbiologia Alimentar. O material apresentou grande contaminação por microrganismos saprófitas, bactérias aeróbias e anaeróbias, Gram positivas e negativas, proteolíticas, pigmentadas, esporuladas, leveduras e fungos. A alta incidência das bactérias halofílicas "vermelhas", responsáveis pela deterioração de carnes, pescados e outros produtos salgados foi estudada. A freqüência, em 15 amostras de SAL, de bactérias esporuladas termorresistentes foi calculada em 33%, possuindo um SAL germe termofílico. Para anaeróbios a positividade foi de 80%, havendo esporulação em 40% das culturas isoladas. Os índices para leveduras e fungos foram de 73% e 93%, respectivamente.19 samples of marine salt (NaCl, granular type, from different salines, were analized to verify the microbial flora and the presence of "food-poisoning" bacteria. The material presented a great contamination by saprofit microorganisms, aerobic and anaerobic bacteria Gram positives and negatives, proteolitics, pigmented, sporulated, yeast and fungi. The high incidence of "red halophilic bacteria", responsible for meat deterioration, fish and other salted products, was studied. The frequence, in 15 samples of salt, of sporulated heat-resistant bacteria was estimated at 33% containing one salt termophilic germ. For anaerobic microorganisms the positiveness reached 80%, sporulation processed in 40% of the isolated cultures. The index for yeast and fungi was 73% and 93%, respectively.

Sal die ‘ewolusie’ vanaf biologie na lewenswetenskappe ‘uitsterwing’ van die vakgebied voorkom?

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Johanna G. Ferreira

2012-03-01

Full Text Available In hierdie artikel word die wysiging van die skoolvak van ‘biologie’ na ‘lewenswetenskappe’ bespreek, asook die gepaardgaande en verwagte implikasies van die verandering. Die vraag word gestel of die beoogde wysiging wel noemenswaardig is en of dit enigsins ‘n verskil aan die dalende belangstelling in die lewenswetenskappe op tersiêre vlak sal maak. Die wysigings in die nuwe kurrikula verhoog die relevansie van die vakinhoud vir leerders en vir die gemeenskap, maar sekere kwessies kry nie aandag nie. Voorstelle word gemaak om die kurrikulum te wysig en onderrigmetodes aan te pas om die nodige vaardighede by leerders te vestig.

OPTIMIZACIÓN DE LA LOGÍSTICA DE OPERACIONES DE UNA PLANTA DE MOLIENDA DE SAL

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Oscar Araya Pasten

2001-09-01

Full Text Available

El presente trabajo tuvo como objetivo desarrollar un modelo de simulación mediante el uso del software Awesim para optimizar el sistema de producción y transporte de sal de una empresa minera del norte de Chile, con la finalidad de incrementar la productividad mediante la reducción de los tiempos de detención de la planta de producción, compatibilizando los ciclos de llenado de las tolvas de almacenamiento con los ciclos de transporte de los camiones.

La comunidad sefardita de Salónica después de las guerras balcánicas (1912-1913)

OpenAIRE

Morcillo Rosillo, Matilde

1993-01-01

Esta comunicación no pretende ir más allá de una primera aproximación al colectivo de judíos españoles de Salónica tras finalizar las guerras balcánicas. Un período justificado en sí mismo por cuanto coincide con el hundimiento del Imperio otomano y el resurgimiento de la nueva Grecia, lo que dificultará las relaciones de convivencia entre israelitas y griegos.

Investigación: La historia de la sal en México, las salinas de Cuyutlán y el caso de la cooperativa de salineros de Colima

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Oriana Zaret Gaytán Gómez

2015-11-01

Full Text Available En México, y en muchos lugares del mundo, existen productores artesanales que extraen sal de maneras casi tan autóctonas como lo hicieron nuestros antepasado prehispánicos. En este trabajo se pretende exponer el caso de una cooperativa ubicada en la región de Cuyutlán, en el Estado de Colima, que, si bien ya ha implementado algunas innovaciones, aún sigue utilizando el trabajo intensivo para poder llevar a cabo la extracción de la sal. Conoceremos un poco de la historia de la cooperativa, de los conflictos que enfrentó durante su constitución y a lo largo de toda su existencia. Asimismo, se abordará el tema de la cultura regional que ha emergido alrededor de ella. Antes de exponer dicha situación, se presentará un panorama general de lo que ha sido la historia de la sal en México antes y después de la llegada de los españoles, durante el México independiente y la Revolución, hasta llegar a la situación actual; ello con el fin de contextualizar la investigación y poner en antecedentes al lector de la importancia de este mineral en la historia de nuestro país. Para finalizar el trabajo, se expondrá la realidad presente y pasada de las salinas de la Costa de Colima para con ello exponer la pertinencia de estudiar a mayor profundidad el fenómeno de explotación de la sal a través de dicha sociedad, la cual el 1º de enero de 2015 cumplió 90 años de existencia.

Effectiveness of sal deoiled seed cake as an inducer for protease production from Aeromonas sp. S1 for its application in kitchen wastewater treatment.

Science.gov (United States)

Saini, Vandana; Bhattacharya, Amrik; Gupta, Anshu

2013-08-01

The present study is an attempt to demonstrate the feasibility of sal (Shorea robusta) deoiled cake--a forest-based industrial by-product--as a cheaper media supplement for augmented protease production from Aeromonas sp. S1 and application of protease in the treatment of kitchen wastewater. Under optimized conditions, protease production could successfully be enhanced to 5.13-fold (527.5 U mL(-1)) on using sal deoiled seed cake extract (SDOCE), as medium additive, compared to an initial production of 102.7 U mL(-1) in its absence. The culture parameters for optimum production of protease were determined to be incubation time (48 h), pH (7.0), SDOCE concentration (3 % (v/v)), inoculum size (0.3-0.6 % (v/v)), and agitation rate (100 rpm). The enzyme was found to have an optimum pH and temperature of 8.0 and 60 °C, respectively. The protease preparation was tested for treatment of organic-laden kitchen wastewater. After 96 h of wastewater treatment under static condition, enzyme preparation was able to reduce 74 % biological oxygen demand, 37 % total suspended solids, and 41 % oil and grease. The higher and improved level of protease obtained using sal deoiled seed cake-based media hence offers a new approach for value addition to this underutilized biomass through industrial enzyme production. The protease produced using this biomass could also be used as pretreatment tool for remediation of organic-rich food wastewater.

Análise epidemiológica de lesões no futebol de salão durante o XV Campeonato Brasileiro de Seleções Sub 20 Análisis epidemiológico de las lesiones en el fútbol de salón durante el XV Campeonato Brasileño de Selecciones Sub 20 Epidemiologic analysis of injuries occurred during the 15th Brazilian Indoor Soccer (Futsal Sub20 Team Selection Championship

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Rodrigo Nogueira Ribeiro

2006-02-01

Full Text Available INTRODUÇÃO: Vários autores têm investigado a incidência de lesões no futebol. Entretanto, poucos trabalhos têm analisado as lesões no Futebol de Salão. O objetivo deste estudo foi analisar a incidência, circunstâncias e características das lesões registradas no Futebol de Salão durante o XV Campeonato Brasileiro de Futebol de Salão Sub 20. MÉTODOS: Fisioterapeutas ou médicos de todas as seleções participantes do XV Campeonato Brasileiro de Futebol de Salão Sub 20 responderam a um questionário para investigar a ocorrência de lesões durante as partidas. A taxa de resposta foi de 100%. RESULTADOS: Um total de 32 lesões foi registrado durante as 23 partidas, com incidência de 1,39 lesão por partida ou 208,6 lesões por 1.000 horas/jogo. Aproximadamente 1 a 3 lesões por partida resultaram em afastamento de jogadores em partidas ou treinamentos. As lesões de contato eram predominantes em 65,62% (21 das 32 lesões e a maioria dessas lesões não resultou no afastamento dos jogadores. CONCLUSÕES: O presente estudo observou que a incidência das lesões durante o XV Campeonato Brasileiro de Futebol de Salão Sub 20 foi semelhante à registrada em torneios de Futebol de Salão, mas superior aos achados em torneios de futebol, caracterizando a especificidade do esporte. Entretanto, circunstâncias e características são similares entre eles devido à semelhança de demanda do esporte.INTRODUCCIÓN: Varios autores han estado investigando la incidencia de lesiones en el fútbol. Sin embargo, pocos trabajos han estado analizando las lesiones en el fútbol de salón. El objetivo de este estudio fue el de analizar la incidencia, y las circunstancias, y características de las lesiones registradas en el fútbol de salón durante el XV Campeonato Brasileño de Fútbol de salón Sub 20. MÉTODOS: Médicos y/o fisioterapeutas del todos los participantes del XV Campeonato Brasileño de Fútbol de salón Sub 20 contestaron una encuesta

La comunidad sefardita de Salónica después de las guerras balcánicas (1912-1913

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Matilde Morcillo Rosillo

1993-01-01

Full Text Available Esta comunicación no pretende ir más allá de una primera aproximación al colectivo de judíos españoles de Salónica tras finalizar las guerras balcánicas. Un período justificado en sí mismo por cuanto coincide con el hundimiento del Imperio otomano y el resurgimiento de la nueva Grecia, lo que dificultará las relaciones de convivencia entre israelitas y griegos.

Traditions matrimoniales dans la région de Rabat-Salé-Zemmour-Zaer au Maroc

OpenAIRE

Hami, H.; Soulaymani, A.; Mokhtari, A.

2011-01-01

La pratique des mariages consanguins est très répandue au Moyen-Orient, en Afrique du Nord et dans le Sud-Ouest Asiatique où 20 à plus de 50 % de mariages sont consanguins. L’analyse d’un échantillon de 270 femmes mariées, pris au hasard dans le service de Maternité de l’Hôpital Souissi à Rabat (2004-2005), a fait l’objet d’une étude prospective visant à déterminer la fréquence des mariages consanguins dans la région de Rabat-Salé-Zemmour-Zaer au Maroc. Les résultats obtenus montrent que 20...

Preparation and characterization of Tb3+ and Tb(sal)3.nH2O doped PC:PMMA blend

International Nuclear Information System (INIS)

Dwivedi, Y.; Singh, A.K.; Prakash, Rajiv; Rai, S.B.

2011-01-01

Tb doped polycarbonate:poly(methyl methacrylate) (Tb-PC:PMMA) blend was prepared with varying proportions of PC and PMMA. Thermal and spectroscopic properties of the doped polymer have been investigated employing Fourier Transform Infrared (FTIR) absorption and differential scanning calorimetric (DSC) techniques. PC:PMMA blend (with 10 wt% PC and 90 wt% PMMA) shows better miscibility. Optical properties of the dopant Tb 3+ ions have been investigated using UV-vis absorption and fluorescence excited by 355 nm radiation. It is seen that luminescence intensity of Tb 3+ ion depends on PC:PMMA ratio and on Tb 3+ ion concentration. Concentration quenching is seen for TbCl 3 .6H 2 O concentration larger than 4 wt%. Addition of salicylic acid to the polymer blend increases the luminescence from Tb 3+ ions. Luminescence decay curve analysis affirms the non-radiative energy transfer from salicylic acid to Tb 3+ ions, which is identified as the reason behind this enhancement. - Highlights: → Blend formation is confirmed at PC/90PMMA, using FTIR and DSC techniques. → Absorption and bandgap studies of blend and parent components were studied. → Optical properties of Tb and Tb(sal) 3 .nH 2 O complex have been studied in PC/PMMA blend. → Luminescence decay curves confirm non-radiative energy transfer from Sal to Tb 3+ ions.

El sueño premonitorio de Moisés Almosnino sobre Yosef Nasí en el Tratado de los sueños (Salónica 1564

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Romeu Ferré, Pilar

2004-06-01

Full Text Available Moshe Almosnino and Yosef Nasi did not only share a common political and social context, namely Salónica, Constantinople in the 16th century. They also devoted their time and effort to help the Sephardic people of the Diaspora to which they both belonged. One can say that their work got rewarded as the premonitory dream was fulfilled.Dos personajes famosos, Moisés Almosnino y Yosef Nasí, coincidieron en un espacio geográfico y temporal común (Salónica-Constantinopla a mediados del siglo XVI. Ambos trabajaron desde allí denodadamente en favor del pueblo sefardí en la diáspora. La realización del sueño premonitorio vendría a colmar las expectativas de ambos.

Influencia del consumo de sal y de analgésicos efervescentes con sodio en pacientes con hipertensión y riesgo vascular

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Martínez Pérez SR

2010-12-01

Full Text Available La ingesta del sodio que contienen los alimentos y algunos medicamentos puede producir una elevación de los valores de presión arterial de los individuos. La Organización Mundial de la Salud recomienda de forma global no superar la ingesta diaria de 2 g de sodio en los adultos sanos (5 g de sal común. Para grupos de riesgo se establecen límites más estrictos (0,5-1,5 g de sodio diarios. En España se estima que cada persona consume al día 11 g de sal por término medio. Diversos estudios, realizados en distintas poblaciones, han podido objetivar una correlación directa entre la ingesta de sodio en la dieta y la prevalencia de hipertensión arterial. Otros estudios corroboran el efecto de la reducción del consumo de sal en la dieta sobre la disminución de los valores de presión arterial y de la morbilidad y mortalidad cardiovascular. Muchos medicamentos contienen una elevada cantidad de sodio por tener excipientes efervescentes (1 g de paracetamol efervescente puede llegar a aportar más de 0,5 g de sodio, de forma que, si su posología es cada 6-8 horas, pueden superar los límites diarios de sodio recomendados, incluso para un adulto sano. En este artículo se revisa la evidencia disponible sobre el efecto beneficioso de una dieta hiposódica para el control de la hipertensión, las consideraciones sobre el uso de analgésicos y AINE en los pacientes con enfermedad cardiovascular y se insiste en la advertencia de evitar, siempre que sea posible, el uso de medicamentos efervescentes, especialmente en los mayores de 50 años.

Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model

Science.gov (United States)

Obaldía, Nicanor; Nuñez, Marlon; Dutary, Sahir; Lim, Caeul; Barnes, Samantha; Kocken, Clemens H. M.; Duraisingh, Manoj T.; Adams, John H.; Pasini, Erica M.

2016-01-01

Malaria is one of the most significant tropical diseases, and of the Plasmodium species that cause human malaria, P. vivax is the most geographically widespread. However, P. vivax remains a relatively neglected human parasite since research is typically limited to laboratories with direct access to parasite isolates from endemic field settings or from non-human primate models. This restricted research capacity is in large part due to the lack of a continuous P. vivax in vitro culture system, which has hampered the ability for experimental research needed to gain biological knowledge and develop new therapies. Consequently, efforts to establish a long-term P. vivax culture system are confounded by our poor knowledge of the preferred host cell and essential nutrients needed for in vitro propagation. Reliance on very heterogeneous P. vivax field isolates makes it difficult to benchmark parasite characteristics and further complicates development of a robust and reliable culture method. In an effort to eliminate parasite variability as a complication, we used a well-defined Aotus-adapted P. vivax Sal-1 strain to empirically evaluate different short-term in vitro culture conditions and compare them with previous reported attempts at P. vivax in vitro culture Most importantly, we suggest that reticulocyte enrichment methods affect invasion efficiency and we identify stabilized forms of nutrients that appear beneficial for parasite growth, indicating that P. vivax may be extremely sensitive to waste products. Leuko-depletion methods did not significantly affect parasite development. Formatting changes such as shaking and static cultures did not seem to have a major impact while; in contrast, the starting haematocrit affected both parasite invasion and growth. These results support the continued use of Aotus-adapted Sal-1 for development of P. vivax laboratory methods; however, further experiments are needed to optimize culture conditions to support long-term parasite

76 FR 2413 - Notice of Realty Action: Direct Sale of Public Land in Lawrence County, SD

Science.gov (United States)

2011-01-13

... Dakota, to Keith Sauls for the appraised fair market value of $183. DATES: Comments regarding the... proposes to sell this land to Keith Sauls for the appraised fair market value of $183. The public land is...

78 FR 3029 - Notice of Lodging of Proposed Amended Consent Decree Under the Comprehensive Environmental...

Science.gov (United States)

2013-01-15

... (represented by Kenneth Senser as the Executor the Estate of Saul Senser) will pay the United States $243,250... claim, the Estate of Saul Senser, together with Kenneth Senser in his capacity as Executor of the Estate...

Need for coordinated programs to improve global health by optimizing salt and iodine intake Necesidad de programas coordinados para mejorar la salud a escala mundial mediante la optimización de la ingesta de sal y yodo

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Norm R. C. Campbell

2012-10-01

Full Text Available High dietary salt is a major cause of increased blood pressure, the leading risk for death worldwide. The World Health Organization (WHO has recommended that salt intake be less than 5 g/day, a goal that only a small proportion of people achieve. Iodine deficiency can cause cognitive and motor impairment and, if severe, hypothyroidism with serious mental and growth retardation. More than 2 billion people worldwide are at risk of iodine deficiency. Preventing iodine deficiency by using salt fortified with iodine is a major global public health success. Programs to reduce dietary salt are technically compatible with programs to prevent iodine deficiency through salt fortification. However, for populations to fully benefit from optimum intake of salt and iodine, the programs must be integrated. This review summarizes the scientific basis for salt reduction and iodine fortification programs, the compatibility of the programs, and the steps that need to be taken by the WHO, national governments, and nongovernmental organizations to ensure that populations fully benefit from optimal intake of salt and iodine. Specifically, expert groups must be convened to help countries implement integrated programs and context-specific case studies of successfully integrated programs; lessons learned need to be compiled and disseminated. Integrated surveillance programs will be more efficient and will enhance current efforts to optimize intake of iodine and salt. For populations to fully benefit, governments need to place a high priority on integrating these two important public health programs.El alto contenido de sal en la dieta es una causa principal de incremento de la presión arterial, el principal factor de riesgo de muerte a escala mundial. La Organización Mundial de la Salud (OMS ha recomendado que el consumo de sal sea inferior a 5 g/d, una meta que solo logran una pequeña proporción de personas. La falta de yodo puede causar deficiencia cognoscitiva y

Propuesta de sistema de vigilancia de la producción, distribución y consumo de la sal yodada en Cuba

OpenAIRE

Terry Berro, Blanca; Zulueta Torres, Daisy; Paz Luna, Maytell de la

2006-01-01

La implementación de componentes de vigilancia constituye un elemento esencial en cualquier programa de fortificación de alimentos para garanta nacional. El presente trabajo aborda la propuesta de diseño del sistema de vigilancia de la yodación de la sal, elemento indispensable para lograr la sostenibidad del programa. The implementation of surveillance components is an essential element in any food fortification program to guarantee that the beneficiary population receives on account of t...

Suplementação com zinco pode recuperar apetite para refeições de sal Zinc supplementation may recover taste for salt meals

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Dioclécio Campos Jr

2004-02-01

Full Text Available OBJETIVO: Avaliar o efeito do zinco em crianças de 8 meses a 5 anos de idade com falta de apetite para refeições de sal. POPULAÇÃO E MÉTODOS: Estudo duplo-cego com placebo. Dois grupos de crianças apresentando recusa a alimentos de sal foram acompanhados durante 6 meses. As crianças do primeiro grupo receberam 1 mg/kg/dia de zinco sob forma de quelato, durante três meses, enquanto as do segundo grupo receberam uma solução placebo durante o mesmo período. Os dois grupos eram semelhantes quanto a idade, sexo, peso, duração do aleitamento materno, idade de desmame e exames hetamatológicos e bioquímicos. A resposta das crianças ao tratamento foi informada em questionário preenchido regularmente pelas mães. RESULTADOS: 17/20 (85% das crianças que receberam zinco e 10/20 (50% das que receberam placebo recuperaram o apetite para refeições de sal. A diferença foi estatisticamente significativa para p OBJECTIVE: To evaluate the effect of zinc on the appetite for salt foods in children aged 8 months to 5 years. METHOD: Double-blind, placebo-controlled study. Two groups of 20 children refusing to eat salt foods were followed during six months. The children in the first group received zinc chelate 1 mg/kg daily for three months. The second group received a placebo solution. The two groups were similar in terms of age, sex, weight, duration of breastfeeding, age at weaning, biochemical and hematological data. The response of children to treatment was informed by their mothers. RESULTS: 17/20 (85% of the children receiving zinc chelate and 10/20 (50% of the children receiving placebo improved their appetite for salt foods. The difference was statistically significant (p < 0.05, chi-square test. CONCLUSION: Zinc supplementation may improve the acceptance of salt foods by children.

El paisaje como infraestructura. Caso de estudio: el río Salí en el sistema metropolitano de Tucumán (SIMET

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María Paula Llomparte

2013-01-01

Full Text Available La incorporación de la noción de paisaje como infraestructura se presenta como una alternativa estratégica para la generación de un espacio participativo, de calidad ambiental y de inclusión social, que atienda a recursos culturales y naturales en el marco de la planificación del territorio.Las dinámicas y procesos de expansión del Área Metropolitana de Tucumán (AMeT han afectado al río Salí como recurso y a sus paisajes como componentes fundamentales para la concreción de un modelo más cercano a la sustentabilidad. Desde mediados del siglo XX hasta la actualidad se impulsaron numerosos planes y propuestas que procuran revertir esta situación.El presente trabajo propone revisar las diferentes propuestas de actuación en los márgenes del Salí a los fines de evaluar si propician o atienden al paisaje como elemento estructurante del espacio metropolitano. Se argumenta que los planes propuestos se reproducen desde una lógica netamente extractivista, afectando al río como patrimonio cultural y ambiental y desatendiendo el aprovechamiento responsable de los recursos territoriales.

Eliminación de sal inorgánica residual producida en la fermentación farmacéutica por nanofiltración y ósmosis inversa: experimento y modelo matemático

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Jesús Mora Molina

2007-05-01

Full Text Available El problema del agua residual con altos contenidos de sal es una importante preocupación de las autoridades medioambientalistas. Los metódos de tratamientos de aguas residuales existentes, tanto municipales como industriales, son incapaces de retener eficientemente los compuestos inorgánicos. En este trabajo se presentan nuevos resultados con membranas de ósmosis inversa (OI y nanofiltración (NF preparadas por las compañías Filmtec y Millipore. Los objetivos principales de esta investigación fueron estos: 1. Encontrar un sistema con alta eficiencia para separar la sal del agua residual generada en el proceso fermentativo farmacéutico y obtener una concentración según lo establecido por la legislación ambiental (concentración de sal: 2500 mg/l, y concentración de los sólidos totales: 1200 mgO2/l; además, que a la planta de tratamiento biológico o directamente al medio ambiente. 2.Determinar la retención de sal demanda química de oxígeno y el flujo del filtrado con sistemas de NF y OI. Asimismo, con base en los datos experimentales, poder describir soluciones similares a las basadas en el modelo de ósmosis a aguas residuales. La temperatura experimental, la presión y el flujo de recirculación fueron mantenidos constantes, en la NF 30°C, 30 bar y 200 l/h, en la OI 30-40°C, 40-50 bar y 300 l/h. En los experimentos de la NF y la OI el factor de concentración fue de Cff = Vaguaori(m3 /Vretenido (m3 = 2,67. Se midieron y se calcularon el flujo del filtrado, la conductividad eléctrica del filtrado, la demanda química de oxígeno y los sólidos totales. En el sistema de OI se obtuvieron los siguientes resultados: contenido de sólidos totales en el agua original 2,06%, en el filtrado, 0,048%; demanda química de oxígeno en el agua original 8750 mg O2/l, en el filtrado 289 mgO2/l. Los resultados demostraron claramente que las membranas de NF investigadas no fueron lo suficientemente eficientes en la retención de sal del agua

SalHUD--A Graphical Interface to Public Health Data in Puerto Rico.

Science.gov (United States)

Ortiz-Zuazaga, Humberto G; Arce-Corretjer, Roberto; Solá-Sloan, Juan M; Conde, José G

2015-12-22

This paper describes SalHUD, a prototype web-based application for visualizing health data from Puerto Rico. Our initial focus was to provide interactive maps displaying years of potential life lost (YPLL). The public-use mortality file for year 2008 was downloaded from the Puerto Rico Institute of Statistics website. Data was processed with R, Python and EpiInfo to calculate years of potential life lost for the leading causes of death on each of the 78 municipalities in the island. Death records were classified according to ICD-10 codes. YPLL for each municipality was integrated into AtlasPR, a D3 Javascript map library. Additional Javascript, HTML and CSS programing was required to display maps as a web-based interface. YPLL for all municipalities are displayed on a map of Puerto Rico for each of the ten leading causes of death and for all causes combined, so users may dynamically explore the impact of premature mortality. This work is the first step in providing the general public in Puerto Rico with user-friendly, interactive, visual access to public health data that is usually published in numerical, text-based media.

SalHUD—A Graphical Interface to Public Health Data in Puerto Rico

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Humberto G. Ortiz-Zuazaga

2015-12-01

Full Text Available Purpose: This paper describes SalHUD, a prototype web-based application for visualizing health data from Puerto Rico. Our initial focus was to provide interactive maps displaying years of potential life lost (YPLL. Methods: The public-use mortality file for year 2008 was downloaded from the Puerto Rico Institute of Statistics website. Data was processed with R, Python and EpiInfo to calculate years of potential life lost for the leading causes of death on each of the 78 municipalities in the island. Death records were classified according to ICD-10 codes. YPLL for each municipality was integrated into AtlasPR, a D3 Javascript map library. Additional Javascript, HTML and CSS programing was required to display maps as a web-based interface. Results: YPLL for all municipalities are displayed on a map of Puerto Rico for each of the ten leading causes of death and for all causes combined, so users may dynamically explore the impact of premature mortality. Discussion: This work is the first step in providing the general public in Puerto Rico with user-friendly, interactive, visual access to public health data that is usually published in numerical, text-based media.

Determinação do melhor nível de sal comum para codornas japonesas em postura Determination of the best level of salt for Japanese laying quails

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Alice Eiko Murakami

2006-12-01

Full Text Available Este estudo foi realizado com o objetivo de determinar o melhor nível de sal comum para codornas japonesas (Coturnix coturnix japonica em postura. Foram utilizadas 336 codornas com 13 semanas de idade, alojadas em gaiolas de 118 cm²/codorna durante 84 dias (quatro ciclos de 21 dias. O delineamento experimental utilizado foi inteiramente casualizado, com sete tratamentos (0; 0,15; 0,20; 0,25; 0,30; 0,35 e 0,45% de sal comum e seis repetições de oito aves por parcela. A cada 21 dias, foram avaliados os parâmetros de desempenho (postura, consumo de ração e conversão alimentar e qualidade dos ovos (peso médio do ovo, massa de ovo, porcentagem e espessura da casca e Unidade Haugh. Os dados obtidos foram submetidos às análises de variância e de regressão e as médias comparadas pelo teste Dunnett a 5% de significância. A equação de regressão ajustada não foi significativa para os parâmetros avaliados em função dos níveis de sal na dieta. Entretanto, pela comparação entre as médias, observou-se que, nos tratamentos com a adição de sal, as aves apresentaram melhor desempenho produtivo e qualidade externa dos ovos, sendo que o nível de 0,15% de sal (equivalente a 0,10% de Na e 0,12% de Cl foi suficiente para obtenção destes resultados.The aim of this experiment was to determine the best level of salt for Japanese laying quails (Coturnix coturnix japonica. Three hundred and thirty-six quails with 13 weeks of age were housed in cages with 118 cm²/quail for 84 days (four cycles of 21 days each. The experiment was analyzed as a complete randomized design with seven treatments (0, 0.15, 0.20, 0.25, 0.30, 0.35, and 0.45% of salt with six replicates of eight quails per pen. Every 21 days, the productive performance (% of production, feed intake and feed gain ratio [kg/kg and kg/dozen] and egg quality (average egg weight, egg mass, eggshell percentage and thickness and Unit Haugh were evaluated. Data were submitted to analyses of

Use of coccidiostat in mineral salt and study on ovine eimeriosis Uso de coccidiostático no sal mineral e estudo da eimeriose ovina

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Alberto Luiz Freire de Andrade Júnior

2012-03-01

Full Text Available Coccidiosis is a serious obstacle to sheep production, which is becoming a limiting factor, especially with regard to lamb production. However, there are few studies on this parasite in the State of Rio Grande do Norte. The aim of this study was to evaluate the action of decoquinate, added to mineral salt, for controlling Eimeria infection in lambs, and to identify which species are infecting sheep in the eastern region of the state. This study was carried out from August 2009 to January 2010, and used 76 animals. These were divided into two treatment groups: one with common mineral salt, and the other with mineral salt enriched with 6% micronized decoquinate. Fecal samples and body weight measurements were taken every 14 days for parasitological diagnosis, weight gain follow-up and quantitative analysis. The study showed that there was a significant difference in OPG only at the 7th collection, but no significant difference in weight gain. The Eimeria species found were E. ahsata. E. crandallis. E. granulosa. E. intrincata. E. ovina. E. faurei. E. ovinoidalis. E. pallida and E. parva. It was concluded that addition of decoquinate to mineral salt gave rise to lower oocyst elimination, thus favoring eimeriosis control in sheep.A coccidiose constitui-se num sério obstáculo à ovinocultura, a qual vem se tornando um fator limitante para a exploração, especialmente para a produção de cordeiros precoces. Porém, poucos são os estudos com esse parasito no Estado do Rio Grande do Norte. O objetivo deste trabalho foi avaliar a ação do decoquinato, adicionado ao sal mineral, no controle da infecção causada por parasitas do gênero Eimeria em cordeiros, e identificar quais as espécies infectam ovinos na região leste Potiguar. O trabalho foi desenvolvido entre agosto de 2009 e janeiro de 2010, e foram usados 76 animais, distribuídos em dois tratamentos, um com sal mineral comum e o outro com sal mineral enriquecido com decoquinato a 6

Uso de sal durante o transporte de juvenis (1kg de pirarucu (Arapaima gigas Use of salt during the transportation of pirarucu juveniles (1kg (Arapaima gigas

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Franmir Rodrigues Brandão

2008-12-01

Full Text Available O pirarucu é um peixe nativo da bacia Amazônica cuja criaçãovem sendo estudada em algumas partes do Brasil. O objetivo desse trabalho foi testar o sal de cozinha como mitigador de estresse durante o transporte de juvenis de pirarucu (1 kg. Para isso, os peixes foram transportados em dois diferentes sistemas: caixas sem adição de oxigênio (transporte aberto e sacos plásticos com injeção de oxigênio e lacrado (transporte fechado. Nos dois sistemas os peixes foram transportados em três diferentes tratamentos: controle e duas concentrações de sal na água (3 e 6 g.L-1. Após o transporte os peixes foram colocados em viveiros para avaliação da recuperação. Foram analisados parâmetros do metabolismo energético (cortisol, glicose e lactato e de hematologia (hematócrito. O sal de cozinha não foi eficiente em mitigar as respostas de estresse no transporte em nenhum dos dois sistemas de transporte estudados.Pirarucu is a native fish of the Amazon basin, widely used in culture systems in some parts of Brazil. The objective of this work was to test table salt as a stress mitigator during transportation of pirarucu juveniles (1kg. Fish were transported by two different systems: boxes without addition of oxygen (open system and closed oxygen filled plastic bags (closed system. To both systems fish were transported at three different treatments: control and two table salt concentration (3 and 6 gL-1. After transportation, fish were stocked in ponds to monitor recovery. Metabolic (cortisol, glucose and lactate and hematological (hematocrit parameters were analyzed. The table salt was not efficient in mitigating stress response during the both tested transport system.

Knowledge, attitudes and self-reported practices toward children oral health among mother's attending maternal and child's units, Salé, Morocco.

Science.gov (United States)

Chala, Sanaa; Houzmali, Soumia; Abouqal, Redouane; Abdallaoui, Faïza

2018-05-11

The occurrence of severe dental caries is particularly prevalent and harmful in children. A better understanding of parental factors that may be indicators of children's risk of developing dental caries is important for the development of preventive measures. This study was conducted to assess knowledge, attitudes, and practices (KAP) of mothers in Salé, Morocco regarding oral health and their predictors. A cross-sectional KAP study was conducted of Mother and Child units in Salé, Morocco. Mothers attending the selected units from November 2014 to 29 January 2015 were recruited. Data were collected using a semi-structured questionnaire, administered by face-to-face interviews, to record socio-demographic factors and KAPs. The main outcome measures included knowledge about oral health diseases and preventive measures, and attitudes and practices related to oral health prevention measures and dental care. KAPs scores were then recoded based on responses and scores were determined for each KAP domain. Linear regression analysis was conducted to assess predictors of KAP scores. Among 502 mothers included, 140 (27.8%) were illiterate and 285 (60.9%) were aware that fluoride has a beneficial effect in caries prevention. Mothers' own practices about dental care were statistically related to their children's use of dental care services (p knowledge score was associated with mother's age (β = 0.05; 95% CI; p oral health-related practices were mother's education level and children's health status. Limited KAP scores were observed among the studied population. A great emphasis on oral health education and some risk factor modifications are recommended.

PREVALENCIA DE BOCIO ENDEMICO POR EL METODO ECOGRAFICO, DETERMINACION DE YODURIAS y YODO EN SAL EN ESCOLARES DEL PARAGUAY.

OpenAIRE

Jara Y, Jorge A; Pretell, Eduardo A; Zaracho de Irazusta, Juana; Goetting, Sonia; Riveros, Claudia

2004-01-01

Paraguay, país mediterráneo ubicado en el corazón de America del Sur, con una superficie de 406.542 Km2 y con una población de 5,8 millones de habitantes importa toda la sal que consume de países cercanos como la Argentina, Brasil y Chile. En el presente estudio observacional, de tipo descriptivo utiliza el método ecográfico para determinar el tamaño y las características de la glándula tiroides, se examinaron 1034 escolares de ambos sexos de 13 distritos del país y fue realizado durante 3 me...

Etkin Piyasalar Hipotezi ve Davranışsal Finans Çatışması(A Conflict Beetween The Efficient Market Hypothesis and Behavioral Finance

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İhsan Kulali

2016-03-01

Full Text Available Etkin piyasalar hipotezi (EPH, çoğu finansal iktisatçı tarafından yaygın şekilde kabul görmektedir. Modeli savunanlar sermaye piyasalarının, hisse senedi fiyatlarının ilgili elde edilebilir tüm bilgileri yansıtması nedeniyle, etkin olduğuna inanmaktadır. Yeni bir bilgi ortaya çıktığı zaman, haberler anında yayılmakta ve hisse senedi fiyatlarına gecikmeksizin yansımaktadır. Bu görüşe göre hisse senetlerinin gelecek fiyatlarının tahmini için teknik ve temel analize ihtiyaç bulunmamaktadır çünkü hiçbir yatırımcının piyasayı yenmesi ve aşırı kar elde etmesi mümkün değildir. Model, bütün yatırımcıların rasyonel ve faydalarını maksimize etmeye çalışan kişiler olduğunu varsaymaktadır. Yirminci yüzyılın başlarında davranışsal finans gündeme gelmiştir. Birçok finansal iktisatçı hisse senedi fiyatlarının en azında belirli ölçülerde tahmin edilebilir olduğuna inanmaktadır. Pek çok piyasa anomalisi ise psikolojik ve davranışsal faktörler ile açıklanmaktadır. Davranışsal finans yatırımcıları rasyonel değil normal olarak kabul etmektedir. Buna göre piyasa balonları ve krizler bilişsel ön yargılardan kaynaklanmaktadır.

Intervenciones para reducir el consumo de sal a través del etiquetado Interventions to reduce salt consumption through labeling

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Javier Sanz-Valero

2012-04-01

Full Text Available OBJETIVO: Determinar el grado en que el etiquetado de productos alimentarios informa acerca del consumo de sal. MÉTODOS: Se realizó un análisis crítico y sistemático de 9 estudios -seleccionados de un total de 133- recogidos mediante revisión de la literatura científica sobre las intervenciones realizadas en población humana orientadas a reducir el consumo de sal a través de mensajes en el etiquetado. Toda la información se obtuvo mediante consulta directa y vía Internet a la literatura científica recogida en varias bases de datos. RESULTADOS: De los 133 artículos recuperados, una vez aplicados los criterios de inclusión y exclusión, se seleccionaron para la revisión 9 trabajos: en todos ellos se planteaba a la población en estudio su conocimiento acerca de la interpretación de la etiqueta sobre el contenido de sal de los alimentos. CONCLUSIONES: Los consumidores de alimentos entienden y valoran más a los logotipos que a la composición nutricional que figura en la etiqueta. Se justificaría entonces el uso de logotipos alternativos que facilitaran esta información y que además fueran normalizados. Esta situación se ve reforzada porque la inclusión de símbolos fácilmente entendibles favorece la correcta elección por parte de los consumidores.OBJECTIVE: Determine the extent to which labeling of food products informs about salt consumption. METHODS: A critical and systematic analysis was conducted of 9 studies selected out of a total of 133 studies. The studies were collected by reviewing the scientific literature on interventions conducted in the human population aimed towards reducing salt consumption through label messaging. All of the information was obtained by direct consultation and by Internet from the scientific literature collected in several databases. RESULTS: Out of the 133 articles recovered, after the inclusion and exclusion criteria were applied, 9 studies were selected for review. All of them took into

Consumer attitudes, knowledge, and behavior related to salt consumption in sentinel countries of the Americas Actitudes, conocimientos y comportamiento de los consumidores en relación con el consumo de sal en países centinelas de la Región de las Américas

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Rafael Moreira Claro

2012-10-01

Full Text Available OBJECTIVE: To describe individual attitudes, knowledge, and behavior regarding salt intake, its dietary sources, and current food-labeling practices related to salt and sodium in five sentinel countries of the Americas. METHODS: A convenience sample of 1 992 adults (≥ 18 years old from Argentina, Canada, Chile, Costa Rica, and Ecuador (approximately 400 from each country was obtained between September 2010 and February 2011. Data collection was conducted in shopping malls or major commercial areas using a questionnaire containing 33 questions. Descriptive estimates are presented for the total sample and stratified by country and sociodemographic characteristics of the studied population. RESULTS: Almost 90% of participants associated excess intake of salt with the occurrence of adverse health conditions, more than 60% indicated they were trying to reduce their current intake of salt, and more than 30% believed reducing dietary salt to be of high importance. Only 26% of participants claimed to know the existence of a recommended maximum value of salt or sodium intake and 47% of them stated they knew the content of salt in food items. More than 80% of participants said that they would like food labeling to indicate high, medium, and low levels of salt or sodium and would like to see a clear warning label on packages of foods high in salt. CONCLUSIONS: Additional effort is required to increase consumers' knowledge about the existence of a maximum limit for intake and to improve their capacity to accurately monitor and reduce their personal salt consumption.OBJETIVO: Describir las actitudes, los conocimientos y el comportamiento individuales con respecto al consumo de sal, sus fuentes alimentarias, y las prácticas actuales de etiquetado de alimentos en relación con su contenido en sal y sodio en cinco países centinelas de la Región de las Américas. MÉTODOS: De septiembre del 2010 a febrero del 2011, se obtuvo una muestra de conveniencia de 1

Simulating SAL formation and aerosol size distribution during SAMUM-I

KAUST Repository

Khan, Basit Ali

2015-04-01

To understand the formation mechanisms of Saharan Air Layer (SAL), we combine model simulations and dust observations collected during the first stage of the Saharan Mineral Dust Experiment (SAMUM-I), which sampled dust events that extended from Morocco to Portugal, and investigated the spatial distribution and the microphysical, optical, chemical, and radiative properties of Saharan mineral dust. We employed the Weather Research Forecast model coupled with the Chemistry/Aerosol module (WRF-Chem) to reproduce the meteorological environment and spatial and size distributions of dust. The experimental domain covers northwest Africa including the southern Sahara, Morocco and part of the Atlantic Ocean with 5 km horizontal grid spacing and 51 vertical layers. The experiments were run from 20 May to 9 June 2006, covering the period of most intensive dust outbreaks. Comparisons of model results with available airborne and ground-based observations show that WRF-Chem reproduces observed meteorological fields as well as aerosol spatial distribution across the entire region and along the airplane\\'s tracks. We evaluated several aerosol uplift processes and found that orographic lifting, aerosol transport through the land/sea interface with steep gradients of meteorological characteristics, and interaction of sea breezes with the continental outflow are key mechanisms that form a surface-detached aerosol plume over the ocean. Comparisons of simulated dust size distributions with airplane and ground-based observations are generally good, but suggest that more detailed treatment of microphysics in the model is required to capture the full-scale effect of large aerosol particles.

Preparation and provisional validation of a large size dried spike: Batch SAL-9934

International Nuclear Information System (INIS)

Jammet, G.; Zoigner, A.; Doubek, N.; Aigner, H.; Deron, S.; Bagliano, G.

1990-05-01

To determine uranium and plutonium concentration using isotope dilution mass spectrometry, weighed aliquands of a synthetic mixture containing about 2 mg of Pu (with a 239 Pu abundance of about 98%) and 40 mg of U (with a 235 U enrichment of about 19%) have been prepared and verified by SAL to be used to spike samples of concentrated spent fuel solutions with a high burn-up and a low 235 U enrichment. Certified Reference Materials Pu-NBL-126, natural U-NBS-960 and 93% enriched U-NBL-116 were used to prepare a stock solution containing 3.2 mg/ml of Pu and 64.3 mg/ml of 18.8% enriched U. Before shipment to the Reprocessing Plant, aliquands of the stock solution are dried to give Large Size Dried (LSD) Spikes which resist shocks encountered during transportation, so that they can readily be recovered quantitatively at the plant. This paper describes the preparation and the validation of a third batch of LSD-Spike which is intended to be used as a common spike by the plant operator, the national and the IAEA inspectorates. 6 refs, 6 tabs

Comparison of Pu isotopic composition between gamma and mass spectrometry: Experience from IAEA-SAL

International Nuclear Information System (INIS)

Parus, J.L.; Raab, W.

1998-01-01

About 2000 Pu containing samples have been analysed during the last 8 years at SAL using gamma spectrometry (GS) in parallel with mass spectrometry (MS). Four different detectors have been used for the measurement of gamma-ray spectra and several versions of the MGA program have been used for spectra evaluation. The results of Pu isotopic composition obtained by both methods have neem systematically compared. Attempts to improve the agreement between GS and MS are described. This was done by adjustment of the emission probabilities for some gamma energies and the development of a new correlation equation for 242 Pu. These improvements have been applied for evaluation of two sets containing 320 and 404 samples, respectively analysed in 1991 and in 1992-93. The mean differences and their standard deviations between MS and GS were calculated, showing mean relative differences for 238-241 Pu isotopes in the range from 0.1 to 0.5% with standard deviations within ± 0.4 to ±1%. For 242 Pu these values are about 0.5% and ± 5%, respectively. (author)

Characterizing Axial Stiffness of Individual Batter Piles with Emphasis on Elevated, Laterally Loaded, Clustered Pile Groups

Science.gov (United States)

2016-11-01

using the appropriate stiffness based on the direction of the calculated pile load. 1...load cases. CPGA utilizes the stiffness method (Saul 1968) of three-dimensional pile group analysis for user-specified static loadings. The pile...CPGA analysis and coordinate systems (global and pile) As discussed in Chapter 1, the CPGA software utilizes the stiffness method (Saul 1968) of

Mihaila Bulgakova Volands un Marijas Korelli Lučija (salīdzinošā analīze)

OpenAIRE

Suhackis, Aleksandrs

2009-01-01

Darbs ir veltīts sātana tēlu romānos «Sātana Sēras» Marijas Korelli un «Meistars un Margarita» Mihaila Bulgakova salidzinošās analīzei. Pētīšanas mērķis ir salīdzināt Lučio Rimanca un Volanda tēlus simvolisma un demonoloģijas tradīcijas aspektā. Īpaša uzmanība ir veltīta arī uz simvolisma tradicijas, dekadanca un romantīsma abskatiem, ar mērķi analīzēt, literārus darbus „Satana Sēras” un „Meistars un Margarita” šaja aspektā. Darbs ir dalīts uz divam daļām. Pirmā ir aprakstīti teoretiskie ...

O diferencial de salários formal-informal no Brasil: segmentação ou viés de seleção?

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Naércio Aquino Menezes Filho

2004-06-01

Full Text Available Neste artigo são investigados os determinantes do diferencial de salários entre os mercados de trabalho formal e informal no Brasil. Utiliza-se um método econométrico de cross-section repetidas (pseudo-paineis, no qual o agrupamento dos dados por geração, tempo e escolaridade permite controlar o fenômeno estudado por características observáveis e não observáveis dos indivíduos. Há fortes evidências de viés de auto-seleção, indicando que os salários mais altos no setor formal decorrem dos melhores atributos individuais não observáveis dos empregados neste setor e não de características intrínsecas a este setor, como seria de se esperar pela hipótese de segmentação.The paper examines the determinants of the wage differential between workers in the formal and informal sectors of the Brazilian labor market. An econometric method of repeated cross-sections (pseudo-panel is used, that allows the researcher to control for observed and unobserved characteristics of the individuals in the sample. We present strong evidence of self-selection bias, meaning that the wage differentials are the consequence of better individual non-observable characteristics of the workers in the formal sector and not to the characteristics of this sector.

Izlases dizainu salīdzināšana ar simulācijas eksperimentu palīdzību

OpenAIRE

Rikačova, Tatjana

2012-01-01

Darbā tika aplūkoti trīs veidu izlases dizaini: vienkāršā gadījuma izlase, sistemātiskā gadījuma izlase un stratificētā gadījuma izlase, kā arī tika apskatīta GREG novērtējumu teorija. Pētījuma mērķis bija ar simulācijas eksperimentu palīdzību salīdzināt iepriekš minētos izlases dizainus, lai noteiktu izlases dizainu, kas dod precīzākus konkrētās populācijas parametru novērtējumus. Lai veiktu simulācijas eksperimentus tika ģenerēti dati un uzrakstītas programmas, kas tika palaistas va...

Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer.

Science.gov (United States)

Itou, Junji; Matsumoto, Yoshiaki; Yoshikawa, Kiyotsugu; Toi, Masakazu

2013-09-17

In cell cultures, the dispersed phenotype is indicative of the migratory ability. Here we characterized Sal-like 4 (SALL4) as a dispersion factor in basal-like breast cancer. Our shRNA-mediated SALL4 knockdown system and SALL4 overexpression system revealed that SALL4 suppresses the expression of adhesion gene CDH1, and positively regulates the CDH1 suppressor ZEB1. Cell behavior analyses showed that SALL4 suppresses intercellular adhesion and maintains cell motility after cell-cell interaction and cell division, which results in the dispersed phenotype. Our findings indicate that SALL4 functions to suppress CDH1 expression and to maintain cell dispersion in basal-like breast cancer. Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Klīnisko atradņu salīdzinājums FemtoLASIK un LASIK metodēs

OpenAIRE

Bistere, Aivija

2010-01-01

Maģistra darbs ir uzrakstīts latviešu valodā uz 60 lpp. Tas satur 36 att., 1 tab., 4 pielikumus. Izmantoti 57 literatūras avoti. Darba mērķis:Novērtēt un salīdzināt klīniskos rezultātus starp metodēm, kur radzenes vāciņš lāzerķirurģijas laikā veidots ar VisuMax femtosekunžu lāzeri(FemtoLASIK metode) un ar mehānisko mikrokeratomu(LASIK metode). Metodika:Pētījumā tika analizēti 84 miopi pacienti(154 acis)-LASIK metodē-59 pacienti,FemtoLASIK-25. Vidējais vecums 29±8 gadi. Pirms operācijas subjek...

Papel do sal iodado na oxidação lipídica em hambúrgueres bovino e suíno (misto ou de frango The role of iodide salts on beef and chicken patties lipid oxidation

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E.A.F.S. TORRES

1998-04-01

Full Text Available No Brasil, a adição de iodo ao sal, com o objetivo de erradicar o bócio, é obrigatório por lei. A adição de sal em produtos cárneos é um problema para a qualidade dos mesmos; tem sido associada à oxidação lipídica e à descoloração de carnes com a presença de metais atuando como catalisadores. Hambúrgueres elaborados com dianteiro bovino e gordura suína ou recortes de frangos, adicionados de gelo, sal, cebola, alho e pimenta in natura foram usados no experimento. Após moldados, os mesmos foram congelados, embalados e estocados. O experimento foi conduzido em triplicata e as amostras retiradas em duplicatas no tempos de 0 a 90 dias. O método de TBA de destilação foi utilizado para acompanhar a oxidação lipídica. Foram determinadas a composição centesimal e os teores de cloreto. Os hambúrgueres misto(carne suína e bovina apresentaram teor de lipídios de 73,31% e por um outro lado, a oxidação lipídica foi mais 54,40% mas ativa nas amostras de frango. A presença de sal iodado (menor que 14,41% parece não ter afetado a oxidação lipídica em ambas as carnes, contrariando a expectativa de que um sal halogênico deveria atuar como um oxidante.In Brazil it’s a legal practice to add iodide to salt. Lipid oxidation is a problem to the quality of meat products. NaCl added to this products acts as a catalyst in lipid oxidation. It has been associated to increasing of TBARS index and also to meat discoloration because of metals contamination. We studied the lipid stability in patties prepared with salt with or without iodide, and mixed with meat from chicken or beef. Ground meat was mixed and ice, salt, onion, garlic and white powder pepper were added, shaped, packaged and stored in freezer. Lipid oxidation was monitored by TBARS (distillation method, in frozen samples and iodide was quantitatively measured throughout 90 days of experiment. The content of lipids in beef samples was 73,31% higher than for chickens one. On

Motivos da prática de dança de salão nas aulas de educação física escolar Reasons for the practice of ballroom dance in the curricular physical activity in schools

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Rodrigo Massami Shibukawai

2011-03-01

Full Text Available O estudo de corte transversal analisou os motivos da prática da dança de salão nas aulas de Educação Física escolar de escolas particulares, relacionando-os com o gênero, seu tempo de prática e participação em eventos de dança de salão. Obteve-se uma amostra de 279 alunos com idade de 15,5 ± 1,0 anos, matriculados nas aulas de dança de salão como Educação Física escolar. Aplicou-se o questionário de motivação para as atividades desportivas - QMAD, adaptado de SERPA e FRIAS (1990 e SERPA (1991. Analisou-se os dados através da estatística descritiva e inferencial, com nível de significância de 95%. Foram encontradas associações significativas entre os motivos e gêneros (r = 0,285; - 0,172; tempo de prática (r = 0,174 e frequência em eventos (r = 0,122; - 0,156. A dança de salão oferece em sua prática uma ferramenta de inúmeras possibilidades, onde cada um de seus praticantes procura preencher as suas próprias necessidades. De acordo com os resultados levantados percebe-se que os alunos estão motivados com a prática de dança de salão na escola havendo diferenças entre o gênero, o tempo de prática e a frequência nos eventos. Diante disto sugere-se a criação de propostas metodológicas condizentes com os principais motivos dos alunos nas aulas de dança de salão dentro do ambiente da Educação Física escolar.The transversal study analyzed the reasons for the practice of ballroom dance in the curricular physical activity in private schools, relating them to the gender, its practice time and participation in ballroom dance events. The study was composed of 279 students at the age of 15.5 ± 1.0, enrolled in ballroom dance as part of regular physical education. The Sport Motivation Questionnaire - SMQ, adapted from SERPA and FRIAS (1990, SERPA (1992 was used. The descriptive and inferential statistics were used with a 95% significance level. Significant associations were found between reasons and the

Tsunami hazard assessment in the coastal area of Rabat and Salé, Morocco

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C. Renou

2011-08-01

Full Text Available In the framework of the three-year SCHEMA European project (www.schemaproject.org, we present a generic methodology developed to produce tsunami building vulnerability and impact maps. We apply this methodology to the Moroccan coast. This study focuses on the Bouregreg Valley which is at the junction between Rabat (administrative capital, and Salé. Both present large populations and new infrastructure development. Using a combination of numerical modelling, field surveys, Earth Observation and GIS data, the risk has been evaluated for this vulnerable area.

Two tsunami scenarios were studied to estimate a realistic range of hazards on this coast: a worst-case scenario based on the historical Lisbon earthquake of 1755 and a moderate scenario based on the Horseshoe earthquake of 28 February 1969. For each scenario, numerical models allowed the production of tsunami hazard maps (maximum inundation extent and maximum inundation depths. Moreover, the modelling results of these two scenarios were compared with the historical data available.

A companion paper to this article (Atillah et al., 2011 presents the following steps of the methodology, namely the elaboration of building damage maps by crossing layers of building vulnerability and the so-inferred inundation depths.

Preparation and provisional validation of a large size dried spike: Batch SAL-9931

International Nuclear Information System (INIS)

Jammet, G.; Zoigner, A.; Doubek, N.; Grabmueller, G.; Bagliano, G.

1990-05-01

To determine uranium and plutonium concentration using isotope dilution mass spectrometry, weighed aliquands of a synthetic mixture containing about 2 mg of Pu (with a 239 Pu abundance of about 98%) and 40 mg of U (with a 235 U enrichment of about 19%) have been prepared and verified by SAL to be used to spike samples of concentrated spent fuel solutions with a high burn-up and a low 235 U enrichment. The advantages of such a Large Size Dried (LSD) Spike have been pointed out elsewhere and proof of the usefulness in the field reported. Certified Reference Materials Pu-NBL-126, natural U-NBS-960 and 93% enriched U-NBL-116 were used to prepare a stock solution containing 1.8 mg/ml of Pu and 37.3 mg/ml of 19.4% enriched U. Before shipment to the Reprocessing Plant, aliquands of the stock solution are dried to give Large Size Dried Spikes which resist shocks encountered during transportation, so that they can readily be recovered quantitatively at the plant. This paper describes the preparation and the validation of a Large Size Dried Spike which is intended to be used as a common spike by the plant operator, the national and the IAEA inspectorates. 6 refs, 7 tabs

Desempenho reprodutivo e metabólitos sanguíneos de ovelhas Ile de France sob suplementação com sal orgânico ou sal comum durante a estação de monta Reproductive performance and blood metabolites from Ile de France ewes fed organic or common salt in the breeding season

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Luiz Antero de Oliveira Peixoto

2010-01-01

Full Text Available Avaliou-se o desempenho reprodutivo de ovelhas sob suplementação com sal orgânico ou sal comum durante a estação de monta e sua associação com os constituintes metabólicos do sangue. O experimento foi conduzido no período de novembro de 2005 a maio de 2006 utilizando-se 40 ovelhas da raça Ile de France. Durante a estação de monta, as ovelhas permaneceram em duas áreas de campo nativo, cada uma com 15 hectares, e foram distribuídas em dois grupos, conforme o tipo de suplementação: recebendo apenas mistura mineral (sal+fosfato ou suplementação diária de sal orgânico. Foram analisados os indicadores bioquímicos do perfil nutricional por meio da quantificação de albumina, ureia, glicose, colesterol e triglicerídeos do soro sanguíneo. As ovelhas sob suplementação com mineral orgânico tiveram teor de nitrogênio ureico sérico superior ao daquelas que receberam mineral na forma tradicional (39,00 vs 35,69 mg/dL, respectivamente. Os demais componentes bioquímicos avaliados não apresentaram diferença entre as formas de suplementação. Os níveis séricos de albumina, ureia, glicose e colesterol apresentaram variação entre os períodos avaliados durante a estação de monta. Os níveis séricos de albumina e nitrogênio ureico não influenciam a taxa de parição das ovelhas. A suplementação com mineral orgânico não melhora os índices reprodutivos do rebanho ovino na estação de monta das ovelhas.The objective of this study was to evaluate the reproductive performance of ewes supplemented with organic or common mineral salt in the breeding season, and the effect on metabolic constituents of the blood. The experiment was carried out from November 2005 to May 2006 using 40 Ile de France breed ewes. During the breeding season, sheep grazed on two native pasture areas of 15 ha each and were distributed in two groups, depending on the supplementation: submitted to treatments: receiving only mineral mix (salt

La solución constructiva de la bóveda encamonada del salón de plenos del palacio del Senado en Madrid (España

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Bustamante, R.

2012-12-01

Full Text Available The constructive type of the timber vault that covers the Plenary Hall of the Palace of the Senate of Spain belonging to the first quarter of the 19th century is analyzed, being composed of the following elements: a rectangular soffit or timber slab with the voids filled up with plaster armed with fibers of esparto, which is hung by means of claspers from a few longitudinal straps of the wooden trusses of the original cover; a half vault formed by double table “camones” supported by a continuous wooden perimeter. By the inner face the soffit and the half vault are provided by plaster and separated by a semicircular perimetric molding in the North and South sides. The papers presents a historical investigation of the changes since the former Augustinian church to the Lounge of Spanish Parliament and Lounge of Plenary sessions, an analysis of the constructive type to which the vault belongs, a geometric characterization and a description of the principal elements.

Se analiza el tipo constructivo de la bóveda encamonada que cubre el Salón de Plenos del Palacio del Senado de España del primer cuarto del siglo XIX, que está compuesta por los siguientes elementos: un plafón rectangular o forjado de tablas con entrevigado de yeso armado con fibras de esparto, que está colgado mediante abrazaderas de unas vigas longitudinales que se apoyan sobre los tirantes de las cerchas de madera de la cubierta original. Y por una semibóveda formada por camones de dobles tablas apoyados en un encadenado perimetral. Por el intradós el plafón y la semibóveda están guarnecidos con yeso y separados entre sí por una moldura perimetral semicircular en los lados Norte y Sur. En el trabajo se presenta una investigación histórica de los cambios registrados desde la antigua iglesia agustina, hasta el Salón de Cortes y Salón de Plenos, un análisis del tipo constructivo al que pertenece la bóveda, una caracterización geométrica y una descripci

Determinación del consumo de sal corriente y sodio en estudiantes universitarios de la Facultad de Medicina. Universidad Nacional Mayor de San Marcos

OpenAIRE

Espinoza Bernardo, Sissy Liliana

2016-01-01

El consumo de sal es un problema de salud cuya ingesta supera la necesidad fisiológica. La ingesta excesiva de sodio es el principal factor de riesgo de la hipertensión arterial así como un contribuyente a enfermedades cardiovasculares, renales y a otras enfermedades crónicas no transmisibles. El estilo de vida de los universitarios y su entorno hace que estén expuestos a un mayor consumo de alimentos ultra procesados y/o alimentos de conveniencia con alto contenido de sodio, déficit de nutri...

Fueros y sal: controversias fiscales entre la provincia de Álava y la corona durante el periodo Borbónico

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María Rosario PORRES MARIJUÁN

2009-11-01

Full Text Available RESUMEN: A partir del reinado de Felipe II, la política fiscal de la Corona en relación a la sal entró en contradicción con algunos de los usos, costumbres y privilegios detentados por las provincias vascas en esa materia. Álava, como consumidora y productora con sus salinas de Añana mantuvo algunas controversias durante el primer período borbónico. Sus autoridades se enfrentaron a la Corona por cuestiones relacionadas con la sal en esta etapa que coincide con una fase evolutiva en la administración aduanera del Distrito de Cantabria. Una fase de reforma que tiene en 1740 la fecha clave, pues es entonces cuando se implanta la administración directa de la Corona sobre las rentas. Su objetivo era doble: la obtención de ingresos más elevados y más regulares, al mismo tiempo que hacer más efectiva la maquinaria aduanera en su fin de perseguir y eliminar las actividades fraudulentas. Álava tuvo que resignarse a la pérdida de ciertos privilegios relacionados con el consumo de la sal, pero nunca llegó a renunciar a los referidos al precio y su exención ante los continuos sobreprecios impuestos por la Corona con fines diversos. Las autoridades alavesas se aferraban a la figura del contrafuero en la medida en la que los fines destinatarios del «crecimiento» solían ser dos materias que los alaveses asumían a través de su propia hacienda: los servicios militares y el reparo de los caminos.ABSTRACT: From Philip ll’s reign onwards, the taxation policy of the Crown in relation to salt came into conflict with some of the uses, customs and privileges retained by the Basque provinces in this field. Alava, as both consumer and producer, with its Añana saltworks, sustained some controversy during the first Bourbon period. Its authorities opposed the Crown on questions related to salt iln this period, which coincided with a developmental phase in the customs administration of the district of Cantabria. The key date of this reform phase was

Bioécologie des Coléoptères (Arthropodes- Insectes) du marais salé de l‘embouchure de la Tafna (Tlemcen).

OpenAIRE

BOUKLI HACENE, Samira

2014-01-01

Le marais salé de l‘embouchure de la Tafna présente plusieurs originalités liées, d‘une part à sa situation naturelle en tant que zone éponge de la zone d‘estuaire du bassin versant de la Tafna et d‘autre part à son état perturbé engendré par une action anthropique intense (mise en place de l‘usine d‘aquaculture et agriculture). L‘hydrologie de surface a révélé des niveaux de submersion différents, ainsi le marais est soumis à des inondations fréquentes déterminant une unité de...

Effets des sels sur la réflectance et télédétection des sols salés

OpenAIRE

Mougenot, Bernard

1993-01-01

La présence de sels dans les sols et les nappes modifie les états de surface. La télédétection facilite leur identification et améliore la cartographie des sols salés. On distingue des effets directs sur la réflectance avec la présence de sels en surface (croûtes ou efflorescences salines), et des effets indirects sur la structure (pseudosables), la végétation (stress salin, végétation spécifique) ou l'absence de végétation dans les cas extrêmes. Les caractéristiques spectrales des sels du vi...

Natureza e civilização: os painéis decorativos do Salão Nobre do Teatro Amazonas Nature and civilization: the decorative panels of the Teatro Amazonas foyer

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Ana Maria Lima Daou

2007-12-01

Full Text Available Os painéis decorativos do salão nobre do Teatro Amazonas singularizam-se em relação ao restante da iconografia que decora o edifício, inaugurado em 1896. Na ocasião, as capitais do Pará e do Amazonas, enriquecidas pela economia gomífera, passaram por significativas transformações no tecido urbano e nas formas de sociabilidade, projetando-se nacional e internacionalmente. O artigo procura identificar paralelos entre as representações paisagísticas da natureza amazônica que decoram o salão nobre do edifício, a construção da cidade moderna e os usos sociais do Teatro Amazonas, símbolo do período e emblema da elite enriquecida que se afirmava no cenário regional e nacional. O Teatro Amazonas ocupou o centro da vida social da época, e em seu salão nobre ocorreram verdadeiros rituais de 'civilização' em que os convidados - brasileiros ou estrangeiros - tinham como cenário privilegiado a natureza amazônica representada nos painéis parietais decorativos.The decorative panels in the foyer of the Teatro Amazonas, inaugurated in 1896, stand out from the rest of the building's ornamental iconography. The rubber trade brought great wealth to the capitals of Pará and Amazonas and as these cities gained national and international fame, their urban fabric and forms of sociability underwent significant changes. The article looks for parallels between the landscape representations of Amazonian nature adorning the building's foyer, the construction of the modern city, and social uses of the Teatro Amazonas, symbol of the era and emblem of the newly rich elite, who were then taking their place on the regional and national stages. The Teatro Amazonas formed the center of the era's social life and its foyer played host to veritable rituals of 'civilization', in which Brazilian and foreign guests enjoyed the fine setting of Amazon's nature as represented in the decorative wall panels.

Determinantes da satisfação e atributos da qualidade em serviços de salão de beleza Determinants of satisfaction and quality attributes in beauty salon services

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José Luis Duarte Ribeiro

2012-01-01

Full Text Available Este artigo apresenta um modelo de representação dos determinantes da satisfação dos clientes de serviços em salões de beleza e dos atributos de qualidade percebidos por eles. Para isso, foram aplicadas duas pesquisas junto a usuários de salões de beleza com a finalidade de: (i determinar as relações entre os determinantes da satisfação dos clientes; e (ii identificar e hierarquizar atributos de qualidade percebidos, de acordo com sua importância para os clientes do serviço em questão. A confirmação de expectativas e a qualidade percebida aparecem como os principais determinantes da satisfação dos clientes. Competência técnica, limpeza do ambiente e dos utensílios, cumprimento de horários e localização conveniente aparecem como os principais atributos de qualidade percebidos. Os resultados desta pesquisa podem ser usados pelos gerentes de salões de beleza para aprimorar a qualidade do serviço e a satisfação dos clientes, estabelecendo um diferencial competitivo para sua empresa.This paper presents a model to represent customer satisfaction determinants and perceived quality attributes in the hairdressing and beauty service segment. Two surveys were applied to beauty salon users with the purpose of: (i determine the relationships among customer satisfaction determinants, and (ii identify and rank attributes of perceived quality, according to their importance for customers of this segment. Confirmation of expectations and perceived quality appear as the main determinants of customer satisfaction. Technical competence, cleanliness of environment and tools, compliance to appointments, and convenient locations appear as the main attributes of perceived quality. These results can be used by managers of beauty salons to improve service quality and customer satisfaction, establishing a competitive advantage for their companies.

É possível determinar a maturidade fisiológica das sementes de milho (Zea mays) utilizando o sal de tetrazólio?

OpenAIRE

Luiz Felipe Nicoleti Torrezan

2016-01-01

Nessa pesquisa foi avaliada a utilização do sal de tetrazólio para determinar a maturidade fisiológica das sementes de milho. As sementes utilizadas foram dos híbridos Pioneer 4285 e Dow 2B587, semeadas em 03/10/2014 e 05/12/2014 respectivamente, e colhidas a partir dos 40 dias após o florescimento (DAF), com intervalos de 4 dias até os 68 DAF. As sementes colhidas foram avaliadas quanto à viabilidade e ao vigor (testes de germinação, de emergência da plântula, de condutividade elétrica, de e...

Geo-diversity and geo-materials in the region of Rabat-Salé-Zemmour-Zaer: Characterization and Rationalization of Utilization

Science.gov (United States)

Belhaj, Siham; Bahi, Lahcen; Akhssas, Ahmed

2016-04-01

The Rabat-Salé-Zemmour-Zaer (RSZZ) is distinguished by a rich geology is varied. Outcrops are found in both the Paleozoic basement, especially along the major wadis in the area and a fairly extensive coverage postpaléozoïque and locally very thick. It offers a wide variety of petrographic facies some of which the construction of geomaterials value (GMC), very solicited by the construction sector and public works (BTP). Among the most important GMC furniture and beds of RSZZ: - The sands. They are a fundamental component for the preparation of mortar and hydraulic concrete. They also enter into the composition of adobe and are used for the foundation of shoes. -The Clays. They are mainly used by ceramists (industrial units manufacturing tiles). The red clay of Triassic age are most represented in the Region in deposits whose thickness can reach several tens of meters. -The Calcarenite. : It is the most used local stone in building the cities of Rabat and Salé, where she is well known as the Stone of Salé. The same stone is used in the manufacture of lime through calcination. Geologically, it is a calcareous sandstone, of Pliocene-Quaternary age that is in the form of a dune system that runs parallel to the Atlantic coast. -The Limestones: These massive limestones and more or less metamorphosed dolomitized Devonian. These limestone outcrop along major wadis of the region (Akrech, Ykem, ...) as layers sometimes quite thick and more or less tectonized. According to localities, these limestones show a wide range of colors (white, gray, black pink) and a wide variety of structures (colorful, beaded, veined, textured) - The quartzites. They correspond to Ordovician bars that appear quite often emerged in relation to other surrounding formations because of their high resistance to erosion. The rock is generally brownish gray and shows a very high hardness related to its siliceous. Local and temporary holdings allow blocks extraction for various public works

Jihâd dalam Pandangan Muhammad ‘Abd al-Salâm Faraj

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Abdul Muis Naharong

2014-01-01

Full Text Available Jihâd is one of the Islamic teachings which has been extensively discussed since the last few decades due to the increasing acts of violence perpetrated by some Muslims. This article tries to join this discussion by presenting Muh ammad ‘Abd al-Salâm Faraj’s concept of jihâd and his ideas of Islamic state and Caliphate by referring to his al-Farîd ah al-Ghâ’ibah (the Neglected Duty. We argue that Faraj’s basic perception of the Egyptian politics and society at the time shaped his whole concept of state and Caliphate. We hence contend that his proposal of jihâd is born out of his disappointment of the Egyptian government and even society as far as applying Islamic law is concerned. He uncompromisingly believed that the government and society are hypocrite and apostate for distancing themselves from the divine law of God. This belief prompted four members of Jihâd Organization to which Faraj belongs, to assassinate President Sadat in October 1981. By jihad, Faraj means fighting and confrontation against enemies even through bloodshed. And by enemies he means anyone who is not willing to apply God’s law on earth. The most controversial idea that Faraj has tried to pose is that jihâd is considered to the sixth pillar of Islam, which has to be carried out by each and every member of Muslim ummah.

Populism in Latin America

Science.gov (United States)

2009-03-20

Justicialist Party). In the first round of voting in April 2003, he finished a close second to former president Carlos Saul Menem . Shortly before the...scheduled runoff, however, Menem —trailing 15 Kirchner by a wide margin in opinion polls—withdrew his candidacy, and Kirchner became president-elect by default...A week later, Kirchner was sworn in as the president.16 Since the second presidential term of Carlos Saul Menem (July 8, 1995 – December 9, 1999

Ingesta de sal yodada en hogares y estado nutricional de yodo en mujeres en edad fértil en Perú, 2008 Iodized salt intake in households and iodine nutritional status in women of childbearing age in Peru, 2008

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Ana María Higa

2010-06-01

Full Text Available Objetivo. Estimar el estado nutricional de yodo en mujeres en edad fértil y evaluar la ingesta de sal adecuadamente yodada en sus hogares en el Perú. Materiales y métodos. Estudio transversal realizado con un muestreo probabilístico multietápico por conglomerados que incluyó 1573 hogares y 2048 mujeres en edad fértil, distribuidas en cinco dominios (Lima, resto de costa, sierra rural, sierra urbana y selva. Se evaluó el uso de sal yodada en hogares y el yodo urinario en mujeres en edad fértil. Resultados. El 97,5% (IC95%: 96,7 - 98,5% de hogares peruanos consumen sal yodada, siendo menor en sierra rural (95% y mayor en Lima metropolitana (100%. La mediana de yoduria nacional fue de 266 μg/L, siendo menores en la selva (206 μg/L y mayores en el resto de costa (302 μg/L, estos valores se encuentran por encima del lνmite recomendado por la Organizaciσn Mundial de la Salud en todos los dominios (mediana mayor a 200 μg/L, valor que asegura un control de desσrdenes por deficiencia de yodo (DDI. Conclusiones. En control de los DDI por el consumo de sal yodado es bueno, se debe continuar con la vigilancia de la presencia de yodo en la sal, particularmente en las αreas con menor acceso.Objective. To estimate the iodine nutritional status in women of childbearing age and to evaluate the intake of salt adequately iodized in their households in Peru. Materials and methods. Cross-sectional study performed with a multistage, probabilistic, cluster sampling that included 1573 households and 2048 women in childbearing age, distributed in five domains (Lima, rest of the coast, rural highlands and jungle area. The use of iodized salt was evaluated in the households and the urinary iodine was evaluated in the childbearing age women. Results. 97.5% (95%CI. 96.7-98.5% of peruvian households have iodized salt consumption, being it lower in the rural highland (95% and higher in Lima (100%. The national mean of urinary iodine was 266 μg/L, being it

Salón social del club natación Metropole Las Palmas de Gran Canaria, España

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López Díaz, Luis

1978-02-01

Full Text Available This hall is the first stage of an ambitious programme of reforms and extensions to the Metropole Swimming Club which, apart from increasing and diversifying the number of the sports installations, includes others of an eminently social nature. The numerous conditioning factors which limited the construction of the hall from the beginning, both regarding the surface —rectangular and extremely elongated, messuring 13 x 13 m, and height— about 3 m, and regarding its situation within the whole, lead to the arrangement of three articulated atmospheres within a single space, covered with thin reinforced concrete warped membranes, as the only solution capable, on the one hand, of reducing the coldness and stiffness of the structure imposed, and on the other, of satisfactorily answering the design bases which prefixed multifunctionality, transparency and representativity of the building. A final premiss which called for the integration of the work in a surrounding gardaned environment was solved by the complete glazing of the frontages and the light tones of the finishing materials.

Este salón es la primera fase de un ambicioso programa de reformas y ampliaciones para el Club Natación Metropole que, además de aumentar y diversificar el número de las instalaciones deportivas, incluye otras de carácter eminentemente social. Los numerosos condicionantes que desde un principio limitaron la construcción del salón, tanto en cuanto a superficie —rectángulo sumamente alargado de 13 x 33 m— y altura —unos 3 m—, como a su situación dentro del conjunto, condujeron a la organización de tres ambientes articulados dentro de un espacio único, cubiertos con sendas membranas delgadas de hormigón armado, de formas alabeadas, como única solución capaz, por una parte, de reducir la frialdad y rigidez de la conformación impuesta, y por otra, de responder satisfactoriamente a las bases de diseño que prefijaban la multifuncionalidad

Pašnāvības ziņu rāmējums latviešu, krievu un britu ziņu portālos: salīdzinošā analīze

OpenAIRE

Kozlovska, Alīna

2014-01-01

Bakalaura darba „Pašnāvības ziņu rāmējums latviešu, krievu un britu ziņu portālos: salīdzinošā analīze” pētāmā problēma ir pašnāvības ziņu mediācija atbilstoši ētikas principiem. Darba mērķis ir izpētīt portālu publikāciju rāmējumus un vēstījumos paustās attieksmes pret dzīves brīvprātīgu pārtraukšanu, salīdzinot dažādās mediju vidēs konstatētos rezultātus. Darba teorētiskajā daļā apskatītas interneta un jaunāko tehnoloģiju īpatnības, sensibilo tematu komunikācijas īpatnības un nāves medi...

Eiropas Savienības uzņēmējdarbības vide start-up uzņēmumu attīstīšanai (salīdzinošā analīze ar ASV)

OpenAIRE

Kapenieks, Kristaps

2014-01-01

Maģistra darbā „Eiropas Savienības uzņēmējdarbības vide start-up uzņēmumu attīstīšanai (salīdzinošā analīze ar ASV)” tiek pētīts, kā uzņēmējdarbības vide ietekmē start-up uzņēmējdarbības aktivitāti un kur uzņēmējdarbības vide ir piemērotāka start-up uzņēmējdarbībai – Eiropas Savienībā vai ASV. Lai iegūtu atbildi uz šiem jautājumiem, maģistra darbā tiek pētīts, kas ir start-up uzņēmums un kā to ietekmē ārējā uzņēmējdarbības vide, salīdzināti vides faktoru dati par četrām Eiropas Savienības da...

Preparação, caracterização e aplicação de capilares modificados com quitosana e sal de quitosana quaternizada em eletroforese capilar

OpenAIRE

Vitali, Luciano

2012-01-01

Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química O objetivo do presente estudo foi modificar internamente capilares de sílica fundida com quitosana (QTS) e sal de quitosana quaternizada (SAQQ), além do uso do polímero aniônico ?-carragena e do agente reticulante glutaraldeído empregado na reticulação da QTS e do SAQQ, e explorar algumas de suas aplicações em eletroforese capilar. Os capilares foram rev...

El piano de la música de salón. Un estudio de caso en Guadalajara de Buga, 1890-1930

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Maria Victoria Casas Figueroa

2010-01-01

Full Text Available El artículo analiza, a partir de las partituras empastadas y obras manuscritas, entre otro tipo de fuentes, la música de salón y la interpretación del piano en Guadalajara de Buga (Valle del Cauca entre 1897 y 1930. En particular el papel jugado por las mujeres pianistas, los compositores y directores locales. La autora estudia también la composición musical y tendencias registradas, los distintos esquemas rítmicos del vals y el pasillo manifiestos en la escritura de la música para piano. Identifica que para ciertos aires tales como el vals, el pasillo, entre otros, existen diferentes formas de ejecución del instrumento, uso del teclado, y que la armonía del repertorio está dada por el ambiente tonal. El piano se muestra como un factor diferenciador respecto de la colectividad.

Cover beds older than the mid-pleistocene revolution and the provenance of their eolian components, La Sal Mountains, Utah, USA

Science.gov (United States)

Krautz, Jana; Gärtner, Andreas; Hofmann, Mandy; Linnemann, Ulf; Kleber, Arno

2018-04-01

We used uranium-lead (U-Pb) dating of zircons from a tephra layer deposited in the La Sal Mountains to assign an age of more than c. 1.3 Ma to underlying loess-mixed slope deposits (cover beds) and paleosols developed therein. For the first time, we show that properties of cover beds and soils before the Mid-Pleistocene Revolution were similar to those formed after the revolution. However, the deepest exposed carbonate-enriched horizon is much farther developed than younger ones, indicating that there was a period of enrichment by far exceeding intensities of younger calcic horizons some time before the revolution, possibly in Neogene times. Remarkable differences between age distributions of detrital zircons (DZ) within the cover beds allow reconstructing the regional provenance of mixed eolian matter with high accuracy: we were able to trace particular cover beds back to areas with outcropping Permian and Upper Cretaceous rocks.

Evaluación del desarrollo de Salíx humboldtiana, Erythrina edulis y Trichantera gigantea asociados al cultivo de mora sin espina (Rubus glaucus Benth)

OpenAIRE

Guapacha, Cristiam Camilo; Mesa, Jhon Jairo; Patiño, Andrés Alfonso

2015-01-01

En el Municipio de Quinchía, Departamento de Risaralda (Colombia), se evaluó el desarrollo de los tutores vivos Salíx humboldtiana, Erythrina edulis y Trichantera gigantea asociados al cultivo de mora sin espina (Rubus glaucus Benth), también la incidencia de Peronospora sparsa y Oidium sp en plantas de mora asociadas a estos sistemas agroforestales. Se utilizo un diseño de bloques al azar con tres repeticiones cada uno. Los resultados indican que Erythrina edulis es el tutor con mejor adapta...

Aboveground tree biomass in a recovering tropical sal (Shorea robusta Gaertn. f.) forest of Eastern Ghats, India

Energy Technology Data Exchange (ETDEWEB)

Behera, Soumit K.; Misra, Malaya K. [Ecology and Floristic Laboratory, Department of Botany, Berhampur University, Berhampur 760 007, Orissa (India)

2006-06-15

Aboveground biomass of individual tree species by component and total biomass per unit area for four different stages of a recovering tropical dry deciduous forest stands, dominated by sal (Shorea robusta Gaertn. f.) of the Eastern Ghats, India were investigated during 2001-2002. Different periods of recovering (2, 4, 6, and 10-year) forest stands (84{sup o}13'E, 20{sup o}29'N) were selected in the Kandhamal district of Orissa, India and sample trees of all species were harvested. Tree species diversity was 23, 23, 21 and 22 in 2, 4, 6, and 10-year recovering stands, respectively. Species-wise Ixora pavetta showed the highest biomass in 2 and 4-year stands while Shorea robusta in 6 and 10-year stands. Component-wise, in all species, bole-wood contribution ranged between 22.6% and 60.9%. Aboveground tree biomass, in all the stands, was dominated by Shorea robusta, which ranged between 12.68 and 231.91Mgha{sup -1}. Total aboveground tree biomass was 30.12, 49.21, 107.54 and 261.08Mgha{sup -1} in 2, 4, 6 and 10-year stands, respectively. (author)

Crowne Plaza Renovation Retrofit Case Study

Energy Technology Data Exchange (ETDEWEB)

none,

2013-03-01

InterContinental Hotels Group (IHG) and its franchise partner B.F. Saul Company Hospitality Group (B.F. Saul Co.) partnered with the Department of Energy (DOE) to develop and implement solutions to retrofit existing buildings to reduce energy consumption by at least 30% versus requirements set by Standard 90.1-2004 of the American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE), the American National Standards Institute (ANSI), and the Illuminating Engineering Society of North America (IESNA) as part of DOE’s Commercial Building Partnerships (CBP) Program.

Salários e tecnologia num modelo de crescimento com restrição externa Wages and technology in a growth model with external constraints

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Marcus Dutra

2006-04-01

Full Text Available O modelo proposto formaliza uma preocupação que se encontra cada vez com mais freqüência na literatura, a saber, a de que trabalhadores que não têm acesso a condições adequadas de capacitação, saúde e motivação tendem a aprender menos, reduzindo a velocidade de inovação em produtos e processos na firma. Na medida em que a competitividade internacional repousa crescentemente na inovação e/ou na imitação rápida de tecnologia, um nível baixo de desenvolvimento humano implicará oportunidades de crescimento perdidas. Assim, o modelo assume que, até certo valor crítico do salário real, aumentos de salário real produzem aumentos de competitividade e da taxa de crescimento com equilíbrio externo, tornando compatíveis o crescimento econômico e a distribuição da renda, inclusive num contexto de abertura e de intensa concorrência internacional.The model formalizes a topic that the economic literature addresses with increasing frequency, namely that workers who have no access to adequate levels of education, health and motivation tend to learn more slowly and this in turn reduces the rate of innovation in products and processes in the firm. To the extent that international competitiveness increasingly relies on innovation and imitation of technology, a low level of human development will render lost opportunities for growth. Thus, the model assumes that - up to a certain critical level of the real wage - increases in real wages lead to a higher rate of growth consistent with balance-of-payments equilibrium, which makes compatible growth and income distribution even in contexts of external openness and intense international competition.

King Saul’s mysterious malady

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Gillian P. Williams

2012-01-01

Full Text Available This article investigates the ‘illness’ of King Saul (as narrated in the Old Testament. The ‘anti-Saul narrative’ states that ‘God’s spirit had left Saul’ and ‘an evil one had taken its place’ (1 Sm 16:14; also cf. e.g. of his behaviour in 1 Sm 19:24; 1 Sm 18:28−29. The latter years of Saul’s reign were marred by his pre-occupation with David’s growing popularity. He eventually became mentally unstable and suspected everyone of plotting against him. Saul’s battle against the Ammonites, as well as his last battle against the Philistines at Mount Gilboa, was fraught with difficulty. It is postulated that Saul experienced epileptic-like fits and assumedly suffered from some kind of ‘depression’ as a result of post-traumatic stress disorder (cf. 1 Sm 18:9; 1 Sm 18:28, 29; 1 Sm 19:24. This was possibly exacerbated by the enemy herem principle. Talmudic and other perspectives were also provided in the article where possible.

A substituição de trabalhadores como instrumento para redução de gastos com salários: evidências para a indústria paulista

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Veronica Orellano

2009-06-01

Full Text Available O movimento de substituição de trabalhadores por parte das firmas - aqui tratado como churning - é um importante componente da rotatividade da mão-de-obra no Brasil, que também inclui a realocação de emprego entre firmas. A evolução do labor churning ao longo da d��cada de 1990, ao menos para os empregados formais da indústria paulista, segue uma trajetória muito semelhante para as diferentes faixas de tamanho de firmas e para os diferentes subsetores da indústria, sugerindo que mudanças no ambiente macroeconômico afetam o churning de forma similar em firmas com características diferentes. Este artigo propõe um modelo para explicar o movimento de labor churning dos empregados formais no país. O modelo admite que as firmas, ao enfrentarem choques exógenos que elevam o salário real, podem substituir empregados com o objetivo de reduzir seus gastos com salários, particularmente em momentos de baixa inflação, em que há maior rigidez dos salários reais. Um estudo econométrico é realizado a partir dos microdados da RAIS (Relação Anual de Informações Sociais, do Ministério do Trabalho para o setor industrial da Região Metropolitana de São Paulo. Os resultados obtidos corroboram a hipótese do modelo. As estimações ainda sugerem que, no período pós-plano real, controlada a inflação e quando os instrumentos são válidos, o churning da mão-de-obra foi relativamente maior que no início da década de 1990.Labor churning is an important component of labor turnover in Brazil, which includes job reallocation betweenfirms. The labor churning evolution in the nineties, at least for the industrysector in São Paulo, folows a verysimilar path for different groups of firms (divided by size or by subsectors, suggesting that changes in the macroe-conomic environment affect labor churning in a very similar way for different firms. This paper proposes a model to explain the path of formal labor churning in Brazil. The model

Landscape and Astronomy in Megalithic Portugal: the Carregal do Sal Nucleus and Star Mountain Range

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Fabio Silva

2013-02-01

Full Text Available Central Portugal, delimited by the Douro river to the north and the Mondego to the south, is the second densest region of megalithic monuments in the country. The Neolithic archaeological record indicates seasonal transhumance between higher pastures in the summer and lower grounds in the winter. The monuments are found in lower ground and it has been suggested that they were built during the winter occupation of their surroundings. The astronomical orientation of their entrances lends further support to this hypothesis. A recent survey of the orientation of the chambers and corridors of these dolmens, conducted by the author, found good agreement with prior surveys, but also demonstrated that other interpretations are possible. This paper presents an update on the survey, including extra sites surveyed in the spring of 2011, as well as the GIS confirmation of all horizon altitudes that couldn’t be empirically measured. The megalithic nucleus of Carregal do Sal, on the Mondego valley, is then looked at in more detail. It is found that there is a preference for the orientation of dolmens towards Star Mountain Range in-line with the topographic arguments of landscape archaeology. In addition, it was found that the topography also marks the rise of particular red stars, Betelgeuse and Aldebaran, during the period of megalithic building, at the onset of spring marking the transition from low ground to the high pastures. This hypothesis finds further support from toponymic folktales that explain the origin of the name of the mountain range.

Phenotypic characterization and 16S rDNA identification of culturable non-obligate halophilic bacterial communities from a hypersaline lake, La Sal del Rey, in extreme South Texas (USA).

Science.gov (United States)

Phillips, Kristen; Zaidan, Frederic; Elizondo, Omar R; Lowe, Kristine L

2012-02-02

La Sal del Rey ("the King's Salt") is one of several naturally-occurring salt lakes in Hidalgo County, Texas and is part of the Lower Rio Grande Valley National Wildlife Refuge. The research objective was to isolate and characterize halophilic microorganisms from La Sal del Rey. Water samples were collected from the lake and a small creek that feeds into the lake. Soil samples were collected from land adjacent to the water sample locations. Sample salinity was determined using a refractometer. Samples were diluted and cultured on a synthetic saline medium to grow halophilic bacteria. The density of halophiles was estimated by viable plate counts. A collection of isolates was selected, gram-stained, tested for catalase, and characterized using API 20E® test strips. Isolates were putatively identified by sequencing the 16S rDNA. Carbon source utilization by the microbial community from each sample site was examined using EcoPlate™ assays and the carbon utilization total activity of the community was determined. Results showed that salinity ranged from 4 parts per thousand (ppt) at the lake water source to 420 ppt in water samples taken just along the lake shore. The density of halophilic bacteria in water samples ranged from 1.2 × 102 - 5.2 × 103 colony forming units per ml (cfu ml-1) whereas the density in soil samples ranged from 4.0 × 105 - 2.5 × 106 colony forming units per gram (cfu g-1). In general, as salinity increased the density of the bacterial community decreased. Microbial communities from water and soil samples were able to utilize 12 - 31 carbon substrates. The greatest number of substrates utilized was by water-borne communities compared to soil-based communities, especially at lower salinities. The majority of bacteria isolated were gram-negative, catalase-positive, rods. Biochemical profiles constructed from API 20E® test strips showed that bacterial isolates from low-salinity water samples (4 ppt) showed the greatest phenotypic diversity

Retención y Penetración en Estacones de Eucalyptus Saligna. Sometidos a Tratamiento con CuSO4 y Sal CCC, en Baño Caliente y frio y Vacio-Presión

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Escobar C. Oscar

1987-09-01

Full Text Available Este trabajo describe y da los resultados obtenidos con el pretratamiento de estacones de Eucalyptus saligna a tres soluciones de CUS04 y su posterior tratamiento con sales CCA (OSMOSE K-33. El sulfato de cobre se aplicó por el método de baño caliente y frío, seguido por el proceso de difusión durante una semana; para los anteriores tratamientos se usó madera verde o parcialmente seca al aire; las sales CCA se aplicaron a madera seca por el método de vacío-presión. Una de las razones para llevar a cabo este refuerzo de las sales CCA, es haber encontrado postes de eucalipto severamente atacados por hongos, en especial con pudrición blanda. Los estacones fueron tratados inicialmente con soluciones de sulfato de cobre a 1 %, 2% y 3% de concentración; luego los estacones fueron tratados con una solución de sal CCA al 2.5% de concentración por vacío-presión. Se usaron 40 estacones distribuídos en 4 grupos de 10: tres (3 grupos fueron usados para el tratamiento con las soluciones de CUS04 y solución de CCA; el grupo restante fue tratado con la sal CCA únicamente, el cual fue usado como grupo testigo para fines de comparación en los ensayos de campo (cementerios.

Soft soil strengthening by stone columns: case of the embankment under the bridge “Moulay Youssef” (Rabat/Salé

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Nehab Noura

2014-04-01

Full Text Available The soil is generally a heterogeneous material presenting very variable characteristics. In a general way, the main problems related to soils are: low bearing capacity, deformations under static or dynamic loads, large displacements and large settlements of soft soil where the soil moves according to a fixed ground water table. The development of soil mechanics and geotechnical engineering has led to the amelioration of a wide range of soil improvement techniques. These techniques consist in modifying the characteristics of the ground by physical action or by incorporating columnar inclusions made of highly compacted gravel or granular material into the original soil. Stone column is one of the soft ground improvement methods, applicable to a wide range of soil strata and an economical method of support in compressible and cohesive soils. However, there are many difficulties in quantitative analysis of soil column interaction due to the fact that bearing capacity and consolidation behavior of stone column-mat foundation system is affected by various parameters. In the present study, mechanism and various parameters of stone column behavior are investigated by loading tests. Also, tests results are compared to the finite element numerical modeling “Plaxis 2D” (case study: the embankment under the bridge “Moulay Youssef, Rabat/Salé”.

Apport à la connaissance de la bioécologie des Coléoptères des milieux salés et humides de l'ouest algérien

OpenAIRE

BOUKLI HACENE, Samira; HASSAINE, Karima

2010-01-01

Vingt deux espèces de Coléoptères trouvent gîte et couvert dans les micromilieux des marais salés et humides en périphérie de la Sebkha d’Oran. Un exemple d’organisation du peuplement est établi selon la ségrégation spatiale qui a aboutit à subdiviser celle-ci en entité fonctionnelle composé de deux à trois espèces inféodée à des groupements végétaux qui leur sont associés. Douze espèces dont cinq espèces halophiles sont inféodées au groupement à Suaeda fruticosa, situé dans les poin...

Türkiye’de süs bitkileri sektörünün üretim ve yapısal sorunları ve öneriler

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ONAY, Hatice Aslı

2008-01-01

ÖZET:

Bu tez çalışması Türkiye’de süs bitkileri sektörünün üretim ve yapısal sorunlarını analiz ederek bunlara yapıcı ve sürdürülebilir çözümler üretmek amacıyla yapılmıştır. Bunun için öncelikle sektörün ülkemizdeki mevcut durumu ortaya konulmaya çalışılmıştır. Mevcut durumu ortaya koymak için ise sektörün üretim, ithalat ve ihracat verilerinden yararlanılmıştır. Birçok kurum ve kuruluşlardan edinilen bu veriler ışığında sekt...

Käärideta Financial Timesi kallal / Madis Võõras

Index Scriptorium Estoniae

Võõras, Madis

2010-01-01

24.-25. aprillil 2010 ilmus ajalehe Financial Times nädalalõpulisas artikkel riskikapitali investeerijast Saul Kleinist. Viimane on investeerinud ka edukasse tarkvarafirmasse Erply, mida juhib Kristjan Hiiemaa

Veri Transferi Ve İşlem Güvenliğinin Sağlanmasında Kullanılan Şifreleme Yöntemleri Ve Sayısal İmza

OpenAIRE

ANBAR, Adem

2004-01-01

İnternetin ve e-ticaretin gelişmesi ve yaygınlaşması, güvenlik problemlerinin çözümüyle yakından ilişkilidir. Güvenlik sorununu; yetkilendirme, www (world wide web) güvenliği ve veri-işlem güvenliği olmak üzere üç açıdan inceleyebiliriz. Bu çalışmada, yetkilendirme ve www güvenliğine kısaca değinildikten sonra, veri-işlem güvenliği üzerinde ayrıntılı olarak durularak, veri işlem güvenliğinde kullanılan, kriptografi, onay kurumu, elektronik noter, elektronik ve sayısal imza gibi yeni güvenlik ...

Salinidade, sodicidade e propriedades microbiológicas de Argissolo cultivado com erva-sal e irrigado com rejeito salino Salinity, sodicity and microbiological properties of an Ultisol cultivated with saltbush and irrigated with saline effluents

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Célia Maria Maganhotto de Souza Silva

2008-10-01

Full Text Available O objetivo deste trabalho foi avaliar o efeito da irrigação com rejeito da dessalinização, oriundo de tanques de produção de tilápia-rosa, sobre as propriedades químicas e microbiológicas de solos cultivados com erva-sal (Atriplex nummularia Lindl.. Quatro áreas foram usadas, das quais duas foram irrigadas com rejeito salino e cultivadas, durante um e cinco anos, com erva-sal. As outras duas áreas foram conduzidas sem irrigação: uma cultivada com vegetação natural e outra com a halófita. Avaliaram-se os parâmetros relativos à salinidade e sodicidade do solo, e também as seguintes características: carbono da biomassa microbiana (Cmic; relação Cmic/carbono orgânico; atividade das enzimas fosfatase ácida, fosfatase alcalina, beta-glucosidase, protease, L-asparaginase, L-glutaminase. A adição de sais afetou as propriedades físicas e químicas dos solos irrigados com rejeito salino, com tendência à salinização e sodificação. A salinidade afetou as propriedades microbiológicas nos solos irrigados, mas o cultivo da halófita favoreceu a produção das enzimas estudadas. O cultivo da erva-sal em áreas que recebem rejeito salino pela irrigação melhora a qualidade biológica dos solos e sua fertilidade, mas não impede a salinização.The objective of this work was to evaluate the effects of irrigation with saline effluents, from red tilapia production ponds, on chemical and microbiological properties of soils cultivated with saltbush (Atriplex nummularia Lindl. Four areas were used, from which two were irrigated with saline waste and cultivated with A. nummularia, during one and five years. The other two areas were not irrigated, and one was cultivated with natural vegetation and the other with the halophyte. The parameters related to soil salinity and sodicity were evaluated, as well as the following characteristics: microbial biomass carbon (Cmic; Cmic/organic carbon; the activity of acid and alcaline phosphatase

Laulja Elina Bieza esines "Päikesejänku" festivalil / Helju Keskpalu

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Keskpalu, Helju

2002-01-01

Läti televisiooni kutsel osales nende korraldatud laste rahvusvahelisel popmuusika festivalil "Saules zakis 2002" (Päikesejänku 2002) Eesti esindajana stuudio Joy laulja Elina Bieza koos tantsutrupi Richard tantsijatega

Metodologia de pesquisa da história da arte para o estudo de obras de Salões de Arte da década de 1960

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Nelyane Gonçalves Santos

2017-05-01

Full Text Available Na tendência de estudos acerca dos salões na história da arte no Brasil é necessário o desenvolvimento de uma metodologia pautada na análise das obras que compuseram esses eventos. A constituição dos circuitos artísticos a partir da efervescência que os salões geravam entre artistas, críticos e público, nos chama a atenção sobre a necessidade de ampliarmos a compreensão das propostas artísticas vistas a partir da materialidade e visualidade das obras. Isto porque, o estabelecimento de marcos definidores de uma arte brasileira na transição do moderno ao contemporâneo, afastou os discursos históricos das obras e os aproximou da interpretação de fontes documentais, forçosamente associadas aos movimentos de arte em esfera internacional. Assim, a proposta metodológica que aqui se apresenta, coloca o desafio da interpretação das obras a partir de seus próprios vestígios e sentidos, sem desconsiderar a ampliação da pesquisa por meio de fontes documentais que esclareçam, mas não “profetizem” uma revelação de significado para a arte no Brasil da década de 1960. ABSTRACT The trend of studies on the salons in Brazil's art history is necessary to develop a guided methodology in the analysis of the works that made up those events. The constitution of the artistic circuit from the effervescence that the halls generated among artists, critics and the public draws our attention on the need to broaden the understanding of artistic proposals views from the visual and materiality of the works. This is because the establishment of the defining landmarks of Brazilian art in the transition from modern to contemporary, away from the historical discourse of the works and approached the interpretation of documentary sources, necessarily associated with art movements in the international sphere. Thus, the methodological proposal presented here, puts the challenge of interpretation of works from its own traces and directions

Eesti CRM-lahenduste kasv edestab kasvu maailmas kordades / Martin Goroshko

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Goroshko, Martin

2005-01-01

Kliendihaldus- ehk CRM-lahendused, mis aitavad ettevõtetel kliendisuhteid juhtida ja äriprotsesse efektiivsemaks muuta, on saamas populaarseks nii mujal maailmas kui ka Eestis. Diagramm: CRM-i pakkuvate firmade turuosad. Kommenteerib Indrek Saul

AIR PRESSURE and Other Data from TIDE STATIONS From North American Coastline-North and Others from 1972-01-01 to 1974-06-30 (NODC Accession 7601613)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This entry contains tidal information for Chesapeake Bay. Data was submitted by Saul Berkman, NOS Tides Branch, Oceanographic Division. These data are in NODC...

Pihlaka 15 magusat aastat / Urmas Vaino

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Vaino, Urmas, 1974-

2004-01-01

Rakvere kondiitritööstuse AS-i Pihlaka juht Arvo Saul ettevõtte arengust ja tegevusest 15 tegevusaasta jooksul. Diagramm: Tordimeister jätkab edukalt. Vt. samas: Mustikarull, Gurmee ja Paradiisi tort kohvikust

Sal de iodônio aumenta a resistência coesiva de uma resina adesiva experimental na presença de solvente

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Fernanda B. Leal

2013-01-01

Full Text Available Este estudo avaliou o efeito da concentração de solvente na resistência coesiva de um adesivo experimental contendo um derivado do difeniliodônio. Uma blenda monomérica baseada em Bis-GMA, TEGDMA e HEMA foi utilizada como resina adesiva modelo. Foram avaliados dois sistemas de fotoiniciação: um sistema bináriocanforquinona (CQ e etil 4-dimetilamino benzoato (EDAB] e um sistema ternário [CQ, EDAB e hexafluorfosfato de difeniliodônio (DPI]. Nestas resinas foram adicionadas diferentes concentrações de etanol, 0, 5, 10, 20, 30, 40% e teste de resistência coesiva foi utilizado para investigar o efeito deste solvente sobre as propriedades do material. A presença de solvente reduziu a resistência coesiva do polímero, independentemente do sistema de fotoiniciação utilizado. Além disso, o uso do sal de iodônio no sistema de fotoiniciação aumentou a resistência coesiva quando comparado com o sistema binário, e independentemente da concentração de solvente, a resistência coesiva dos polímeros contendo difeniliodônio foi superior à do sistema binário de fotoiniciação.

Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest

International Nuclear Information System (INIS)

Kim, Ju-Hwa; Yoo, Hye-In; Kang, Han Sung; Ro, Jungsil; Yoon, Sungpil

2012-01-01

Highlights: ► Sal sensitizes antimitotic drugs-treated cancer cells. ► Sal sensitizes them by prevention of G2 arrest and reduced cyclin D1 levels. ► Sal also sensitizes them by increasing DNA damage and reducing p21 level. ► A low concentration of Sal effectively sensitized the cancer cells to antimitotic drugs. -- Abstract: Here, we investigated whether Sal could sensitize cancer cells to antimitotic drugs. We demonstrated that Sal sensitized paclitaxcel (PAC)-, docetaxcel (DOC)-, vinblastin (VIN)-, or colchicine (COL)-treated cancer cell lines, suggesting that Sal has the ability to sensitize the cells to any form of microtubule-targeting drugs. Sensitization to the antimitotic drugs could be achieved with very low concentrations of Sal, suggesting that there is a possibility to minimize Sal toxicity associated with human cancer patient treatments. Sensitization by Sal increased apoptosis, which was observed by C-PARP production. Sal sensitized the cancer cells to antimitotic drugs by preventing G2 arrest, suggesting that Sal contributes to the induction of mitotic catastrophe. Sal generally reduced cyclin D1 levels in PAC-, DOC-, and VIN-treated cells. In addition, Sal treatment increased pH2AX levels and reduced p21 levels in antimitotic drugs-treated cells. These observations suggest that the mechanisms underlying Sal sensitization to DNA-damaging compounds, radiation, and microtubule-targeting drugs are similar. Our data demonstrated that Sal sensitizes cancer cells to antimitotic drugs by increasing apoptosis through the prevention of G2 arrest via conserved Sal-sensitization mechanisms. These results may contribute to the development of Sal-based chemotherapy for cancer patients treated with antimitotic drugs.

Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest

Energy Technology Data Exchange (ETDEWEB)

Kim, Ju-Hwa; Yoo, Hye-In; Kang, Han Sung; Ro, Jungsil [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of); Yoon, Sungpil, E-mail: yoons@ncc.re.kr [Research Institute, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do (Korea, Republic of)

2012-02-03

Highlights: Black-Right-Pointing-Pointer Sal sensitizes antimitotic drugs-treated cancer cells. Black-Right-Pointing-Pointer Sal sensitizes them by prevention of G2 arrest and reduced cyclin D1 levels. Black-Right-Pointing-Pointer Sal also sensitizes them by increasing DNA damage and reducing p21 level. Black-Right-Pointing-Pointer A low concentration of Sal effectively sensitized the cancer cells to antimitotic drugs. -- Abstract: Here, we investigated whether Sal could sensitize cancer cells to antimitotic drugs. We demonstrated that Sal sensitized paclitaxcel (PAC)-, docetaxcel (DOC)-, vinblastin (VIN)-, or colchicine (COL)-treated cancer cell lines, suggesting that Sal has the ability to sensitize the cells to any form of microtubule-targeting drugs. Sensitization to the antimitotic drugs could be achieved with very low concentrations of Sal, suggesting that there is a possibility to minimize Sal toxicity associated with human cancer patient treatments. Sensitization by Sal increased apoptosis, which was observed by C-PARP production. Sal sensitized the cancer cells to antimitotic drugs by preventing G2 arrest, suggesting that Sal contributes to the induction of mitotic catastrophe. Sal generally reduced cyclin D1 levels in PAC-, DOC-, and VIN-treated cells. In addition, Sal treatment increased pH2AX levels and reduced p21 levels in antimitotic drugs-treated cells. These observations suggest that the mechanisms underlying Sal sensitization to DNA-damaging compounds, radiation, and microtubule-targeting drugs are similar. Our data demonstrated that Sal sensitizes cancer cells to antimitotic drugs by increasing apoptosis through the prevention of G2 arrest via conserved Sal-sensitization mechanisms. These results may contribute to the development of Sal-based chemotherapy for cancer patients treated with antimitotic drugs.

Desempenho de novilhos suplementados com sal mineral protéico e energético em pastagem no período da seca = Performance of Steers Supplemented in Pasture with Protein-energy Mineral Salt in dry season

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Euclides Reuter de Oliveira

2006-07-01

Full Text Available O trabalho foi realizado objetivando avaliar os efeitos energético e protéico em uplementos múltiplos sobre o ensaio de produção, concentração do N uréico no plasma e parâmetros econômicos de bovinos em fase de recria, manejados em pastagens, durante a época da seca. Foram utilizados 32 novilhos de corte divididos em 4 grupos de 8 animais e analisados por um delineamento de blocos ao acaso a 5% de significância. Cada grupo recebeu um tratamento com pastagem e acrescido de sal mineralizado + uréia + milho; sal mineralizado + uréia + farelo de soja; sal mineralizado + uréia + milho + farelo de soja. Não observou diferença (P>0,05 das suplementações no ganho de peso e o peso médio metabólico, o que pode ser justificado pela qualidade da pastagem aliada à disponibilidade de MS/ha e para a variável N-uréico no sangue indicou o maior teor protéico, oriundo dos 50,0% de participação do farelo de soja na composição do tratamento. A suplementação para animais em pastejo com misturas de natureza múltipla e de baixo consumo proporcionou ganhos de pesoapreciáveis, e sua aplicação depende do preço dos insumos e o da arroba de carne.The research was carried out to evaluate the protein-energy effect of multiple supplements on animal production, N urea in plasmatic quantities and economic parameter of growing beef cattle in pasture during dry season. Thirty-two castrated beef cattle steers were divided into four groups of eight animals. They were analyzedaccording to a randomized block design at 5% of significance. Each group received one treatment to pasture with addition of mineral salt + urea + corn; mineral salt + urea + soybean meal; mineral salt + urea + corn + soybean meal. There was no difference (P>0.05 betweensupplements for daily LWG and for average metabolic weight. This can be justified by forage quality combined with availability of DM/ha. As for the variable N-urea in the blood, results indicated higher protein

Kinoteātru Forum Cinemas, Multikino, Cinamon komunikācija sociālajos tīklos facebook, twitter, instagram 2016 gadā: analīze un salīdzinājums

OpenAIRE

Krahmaļovs, Artūrs Rinats

2017-01-01

Bakalaura tēma “Kinoteātru Forum Cinemas, Multikino, Cinamon komunikācija sociālajos tīklos facebook, twitter, instagram 2016 gadā: analīze un salīdzinājums”. Pētījuma rezultātā tika analizētas kinoteātru publikācijas “Forum cinemas”, “Multikino” un “Cinamon” publikācijas 2016. gadā sociālajos tīklos “Facebook”, “Twitter” un “Instagram”. Visas publikācijas tika sadalītas kategorijās un analizētas pēc noteiktiem kritērijiem. Visi pētāmie materiāli bija brīvi pieejami sociālajos tīklos kinoteā...

Las expediciones a salinas: caravanas en la pampa colonial. El abastecimiento de sal a Buenos Aires (Siglos XVII y XVIII

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Gabriel Darío Taruselli

2005-01-01

Full Text Available El abastecimiento de sal en cantidades sufi cientes fue una de las principales preocupaciones del Cabildo de Buenos Aires. Fue este un producto de importancia vital no sólo por su aplicación en las comidas cotidianas, sino también por su aplicación en la conservación de las carnes y los cueros. Las características de su uso y su obtención, aumentaron su valor, no sólo comercial sino también estratégico. El hallazgo de yacimientos locales permitió a los habitantes de Buenos Aires abastecerse mediante la práctica de expediciones periódicas que fueron promovidas por las autoridades capitulares, lo que les permitió ejercer un mayor control sobre dicha producción. Como la actividad requería una importante capacidad de transporte y de mano de obra, era una práctica aprovechada por muchos para emplearse en ella y para obtener benefi cios con el comercio que se generaba en la oportunidad. Esto convertía a las expediciones a salinas, organizadas por las autoridades de la ciudad, en grandes caravanas que se internaban en pleno territorio indí-gena, involucrando un amplio conjunto de actores sociales tanto de la ciudad como de la campaña y el mundo indígena

Surto de intoxicação por sal em ovinos no estado do Pará

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Marcos D. Duarte

2014-11-01

Full Text Available O presente trabalho relata um surto de intoxicação por sal em ovinos no Brasil, em uma propriedade no estado do Pará. De um total de 545 ovinos, oito animais adoeceram (1,46% e quatro destes morreram (50%. A avaliação das instalações e do manejo indicaram como fatores predisponentes a ingestão excessiva de mistura mineral e a restrição hídrica. Os principais sinais clínicos foram decúbito, diminuição ou ausência da sensibilidade cutânea, ausência dos reflexos de ameaça, palpebral e auricular, midríase, nistagmo, opistótono, espasticidade de membros, sonolência e estupor. Havia ainda, timpanismo, diarreia, taquipneia, taquicardia, desidratação e poliúria. A evolução do quadro clínico nos animais que morreram variou de duas horas e meia a 48 horas. As médias das concentrações séricas de sódio e de potássio de 31 ovinos do mesmo lote afetado pela intoxicação, em amostras colhidas durante o surto, revelaram hipernatremia (190mEq/l e hipercalemia (8,2mEq/l. À necropsia, observou-se em um animal, achatamento das circunvoluções cerebrais. Microscopicamente, neste animal, evidenciou-se vacuolização moderada do neurópilo, particularmente nas lâminas intermediárias do córtex cerebral, com aumento dos espaços perineural e perivascular. Nessas áreas foram observados ainda, acentuada tumefação e edema dos astrócitos e necrose neuronal aguda. A dosagem de sódio no encéfalo de um ovino, revelou-se elevada com valor de 3.513ppm. O diagnóstico foi realizado com base na epidemiologia, nos sinais clínicos, nas lesões macro e microscópicas e nas dosagens de sódio no soro e no encéfalo dos ovinos.

Conocimientos, percepciones y comportamientos relacionados con el consumo de sal, la salud y el etiquetado nutricional en Argentina, Costa Rica y Ecuador Knowledge, perceptions, and behavior related to salt consumption, health, and nutritional labeling in Argentina, Costa Rica, and Ecuador

OpenAIRE

Germana Sánchez; Lorena Peña; Soledad Varea; Patricia Mogrovejo; María Lorena Goetschel; María de los Ángeles Montero-Campos; Raúl Mejía; Adriana Blanco-Metzler

2012-01-01

OBJETIVO: Identificar los conocimientos, percepciones y comportamientos relacionados con el consumo de la sal y el sodio alimentarios y su relación con la salud y el etiquetado nutricional de los alimentos, en tres países de la Región. MÉTODOS: Estudio cualitativo-exploratorio basado en entrevistas semiestructuradas, según las categorías del modelo de creencias en salud. Se realizaron 34 entrevistas y 6 grupos focales con líderes comunales (71 informantes en total) en áreas rurales y urbanas ...

Magritte Meets Kripkenstein

Czech Academy of Sciences Publication Activity Database

Hříbek, Tomáš

1997-01-01

Roč. 45, 3-4 (1997), s. 240-258 ISSN 0049-5123 Institutional research plan: CEZ:AV0Z9009908 Keywords : René Magritte * Michel Foucault * Saul Kripke Subject RIV: AL - Art, Architecture, Cultural Heritage

Critical difference applied to exercise-induced salivary testosterone and cortisol using enzyme-linked immunosorbent assay (ELISA): distinguishing biological from statistical change.

Science.gov (United States)

Hayes, Lawrence D; Sculthorpe, Nicholas; Young, John D; Baker, Julien S; Grace, Fergal M

2014-12-01

Due to its noninvasive, convenient, and practical nature, salivary testosterone (sal-T) and cortisol (sal-C) are frequently used in a clinical and applied setting. However, few studies report biological and analytical error and even fewer report the 'critical difference' which is the change required before a true biological difference can be claimed. It was hypothesized that (a) exercise would result in a statistically significant change in sal-C and sal-T and (b) the exercise-induced change would be within the critical difference for both salivary hormones. In study 1, we calculated the critical difference of sal-T and sal-C of 18 healthy adult males aged 23.2 ± 3.0 years every 60 min in a seated position over a 12-h period (08:00-20:00 hours [study 1]). As proof-of-concept, sal-C and sal-T was also obtained pre and at 5 and 60 min post a maximal exercise protocols in a separate group of 17 healthy males (aged 20.1 ± 2.8 years [study 2]). The critical difference of sal-T calculated as 90 %. For sal-C, the critical difference was 148 % (study 1). Maximal exercise was associated with a statistically significant (p < 0.05) changes in sal-T and sal-C. However, these changes were all within the critical difference range. Results from this investigation indicate that a large magnitude of change for sal-C and sal-T is required before a biologically significant mean change can be claimed. Studies utilizing sal-T and sal-C should appreciate the critical difference of these measures and assess the biological significance of any statistical changes.

Development of lipid-shell and polymer core nanoparticles with water-soluble salidroside for anti-cancer therapy.

Science.gov (United States)

Fang, Dai-Long; Chen, Yan; Xu, Bei; Ren, Ke; He, Zhi-Yao; He, Li-Li; Lei, Yi; Fan, Chun-Mei; Song, Xiang-Rong

2014-02-25

Salidroside (Sal) is a potent antitumor drug with high water-solubility. The clinic application of Sal in cancer therapy has been significantly restricted by poor oral absorption and low tumor cell uptake. To solve this problem, lipid-shell and polymer-core nanoparticles (Sal-LPNPs) loaded with Sal were developed by a double emulsification method. The processing parameters including the polymer types, organic phase, PVA types and amount were systemically investigated. The obtained optimal Sal-LPNPs, composed of PLGA-PEG-PLGA triblock copolymers and lipids, had high entrapment efficiency (65%), submicron size (150 nm) and negatively charged surface (-23 mV). DSC analysis demonstrated the successful encapsulation of Sal into LPNPs. The core-shell structure of Sal-LPNPs was verified by TEM. Sal released slowly from the LPNPs without apparent burst release. MTT assay revealed that 4T1 and PANC-1 cancer cell lines were sensitive to Sal treatment. Sal-LPNPs had significantly higher antitumor activities than free Sal in 4T1 and PANC-1 cells. The data indicate that LPNPs are a promising Sal vehicle for anti-cancer therapy and worthy of further investigation.

Development of Lipid-Shell and Polymer Core Nanoparticles with Water-Soluble Salidroside for Anti-Cancer Therapy

Directory of Open Access Journals (Sweden)

Dai-Long Fang

2014-02-01

Full Text Available Salidroside (Sal is a potent antitumor drug with high water-solubility. The clinic application of Sal in cancer therapy has been significantly restricted by poor oral absorption and low tumor cell uptake. To solve this problem, lipid-shell and polymer-core nanoparticles (Sal-LPNPs loaded with Sal were developed by a double emulsification method. The processing parameters including the polymer types, organic phase, PVA types and amount were systemically investigated. The obtained optimal Sal-LPNPs, composed of PLGA-PEG-PLGA triblock copolymers and lipids, had high entrapment efficiency (65%, submicron size (150 nm and negatively charged surface (−23 mV. DSC analysis demonstrated the successful encapsulation of Sal into LPNPs. The core-shell structure of Sal-LPNPs was verified by TEM. Sal released slowly from the LPNPs without apparent burst release. MTT assay revealed that 4T1 and PANC-1 cancer cell lines were sensitive to Sal treatment. Sal-LPNPs had significantly higher antitumor activities than free Sal in 4T1 and PANC-1 cells. The data indicate that LPNPs are a promising Sal vehicle for anti-cancer therapy and worthy of further investigation.

Sensibilidade gustativa ao sal, natriúria e pressão arterial em indivíduos normotensos Salt taste threshold, 24 hour natriuresis and blood pressure variation in normotensive individuals

Directory of Open Access Journals (Sweden)

Vicente Sperb Antonello

2007-04-01

Full Text Available OBJETIVO: O estudo avalia sensibilidade gustativa ao sal, excreção urinária de sódio e pressão arterial (PA em normotensos. A hipótese foi de que limiar de sensibilidade gustativa ao sal (LSGS aumentado se associasse a maior natriúria em 24 horas e níveis aumentados de PA. MÉTODOS: Foram avaliados 24 voluntários sem diagnóstico de HA. Para avaliar LSGS, usou-se soluções de cloreto de sódio (NaCl em diferentes concentrações. Os voluntários foram submetidos à monitorização ambulatorial da pressão arterial (MAPA de 24 horas e coleta de urina de 24 horas para dosagem de sódio (NaU. Para análise, foram agrupados de acordo com o LSGS, aumentado ou normal. RESULTADOS: Os grupos não diferiram para idade, índice de massa corporal (IMC, variáveis demográficas, uso de álcool, fumo e PA. NaU foi significativamente maior no grupo com LSGS aumentado. Utilizando-se o coeficiente de correlação de Pearson, com significância determinada pelo teste t, houve correlação de forte intensidade entre médias de PA sistólica e diastólica com IMC, de regular intensidade entre LSGS e NaU, assim como para PA sistólica e NaU. CONCLUSÃO: Natriúria de 24 horas foi maior em indivíduos com LSGS aumentado, sugerindo que esta maior avidez ao sal determine maior ingestão de sódio. Houve forte associação entre PA e IMC. Não foi evidenciada associação entre LSGS e PA, diferente do já documentado em pacientes com PA aumentada. Aumentando-se o número de pessoas, faixa etária e pacientes com níveis pressóricos aumentados, talvez se respondam outras perguntas a respeito da relação entre LSGS, natriúria e PA.OBJECTIVE: The study evaluates salt taste sensibility, urinary sodium excretion and blood pressure (BP in normotensive persons. The hypothesis was that a higher salt taste threshold (STT can be associated to a higher 24 hour natriuresis and increased BP levels. METHODS: Twenty four not hypertensive volunteers were selected. To

Genetic pathways to Neurodegeneration Models and mechanisms ...

Indian Academy of Sciences (India)

Paige Rudich

Models and mechanisms of repeat expansion disorders: a worm's eye view ..... retardation 1 gene FMR1 gives rise to a spectrum of neurological disorders (Saul and Tarleton ... autism. Shorter repeat expansion lengths from 55-200 cause the.

L'amélioration de la qualité des huîtres à échelle professionnelle: intégration de l'eau salée souterraine traitée comme milieu d'élevage

OpenAIRE

Haure, Joel; Durin, Olivier; Palvadeau, Hubert; Papin, Mathias; Nourry, Max; Penisson, Christian; Martin, Jean-louis

2003-01-01

Les travaux menés au LCPL depuis plusieurs année sur l'engraissement contrôlé de l'huître creuse Crassostrea gigas ont permis, à l'échelle expérimentale de définir les différents paramètres d 'élevage: température : 14°C ration alimentaire : 2.10(9) cell/ind/j de la diatomée Skeletonema costatum - indice AFNOR initial sans incidence - débit d 'eau : 3 l/ind/h - eau de mer ou eau salée souterraine. Dans ces conditions et après 30 jours d 'engraissement, le poids total des huîtres a progressé d...

Development and reliability of an instrument to measure psychosocial determinants of salt consumption among hypertensive patients Desarrollo y confiabilidad de un instrumento para medir los factores psicosociales determinantes en el consumo de sal entre hipertensos Desenvolvimento e confiabilidade de instrumento para mensuração dos fatores psicossociais determinantes do consumo de sal entre hipertensos

Directory of Open Access Journals (Sweden)

Marília Estevam Cornélio

2009-10-01

Full Text Available This study aimed to present the content validity and reliability analyses of an instrument to study the determinant factors of salt consumption among hypertensive subjects, based on an extension of the Theory of Planned Behavior. Content validity was assessed by 3 experts and a pre-test was carried out with 5 subjects. The final tool, comprising 3 different behaviors related to salt consumption and corresponding psychosocial variables, was applied to 32 subjects for internal consistency and temporal stability (15-day interval analysis. Cronbach's alpha coefficients > 0.70 and significant intra-class correlation coefficients were observed for most variables, indicating the temporal stability of the measured concepts. The developed instrument exhibited evidence of both content validity and reliability.Este estudio tuvo como objetivo presentar el análisis de validez de contenido y de confiabilidad de un instrumento para estudiar los factores determinantes del consumo de sodio entre hipertensos, basado en la extensión de la Teoría del Comportamiento Planificado. El instrumento fue sometido a validez de contenido por 3 jueces y a una prueba piloto con 5 sujetos. El instrumento final, compuesto por 3 comportamientos relacionados al consumo de la sal y por las variables psicosociales correspondientes, fue aplicado a 32 sujetos para evaluación de la consistencia interna y de la estabilidad temporal (intervalo de 15 días. Fueron observados coeficientes alfa de Cronbach>0,70 para la mayoría de las variables y coeficientes de correlación entra clases significativas, que apuntaron la estabilidad temporal de los conceptos mensurados. El instrumento desarrollado mostró evidencias de validez de contenido y de confiabilidad.Este estudo teve como objetivo apresentar a análise da validade de conteúdo e da confiabilidade de um instrumento para estudo dos fatores determinantes do consumo de sódio entre hipertensos, baseado na extensão da Teoria do

Análisis del papel del turismo residencial en la cabecera municipal de Ixtapan de la Sal, Estado de México

Directory of Open Access Journals (Sweden)

Esteban Arias

2007-01-01

Full Text Available El presente artículo es resultado de un trabajo de tesis para la obtención del título de licenciatura. El propósito del estudio fue analizar los efectos que genera el turismo residencial en Ixtapan de la Sal a fin de conocer de manera puntual la incidencia en el desarrollo turístico de este destino. El método aplicado en este trabajo, fue el clínico y se empleó con la finalidad de conocer la situación actual del turismo residencial. Así también, con el método deductivo emanado de la revisión teórica de la propuesta de Daniel Hiernaux en su obra Segundas Residencias fue posible lograr confrontar su teoría con los datos recogidos en campo. A partir de la década de los cuarenta, el turismo en México ha presentado distintas modalidades: el turismo de sol y playa; el turismo religioso o el ecoturismo; particularmente, el turismo residencial es una tendencia de reciente auge, práctica aún cuestionada como modalidad turística por no hacer uso de los servicios de alojamiento hotelero como lo hace el turismo convencional, pero que tiene repercusiones importantes en las comunidades anfitrionas, como es el caso de estudio.

Intervenção Aplicada a um Salão de Beleza para Adequação dos Aspectos Financeiros

Directory of Open Access Journals (Sweden)

Bruna Fernanda Dias

2016-12-01

Full Text Available O relato técnico tem como objetivo apresentar os resultados de intervenções aplicadas nos aspectos financeiros de um salão de beleza, após a realização de uma consultoria na pequena empresa no mês de março em 2016. Foram identificadas dificuldades para apuração do lucro obtido pela organização, resistência para utilização de sistema de informação para controles dos processos e na percepção e formação do preço de venda. Foram realizadas a contabilização das receitas; cálculo da margem de contribuição e do resultado do estabelecimento. A partir do conhecimento do resultado, foi definida uma meta de pró-labore à proprietária, deixando de destinar todo lucro da organização para gastos pessoais. Identificou-se também os valores que podem ser destinados a novos investimentos e futuras necessidades de capital de giro em função da previsão de mudança para uma nova sede. Foi reforçado junto à empresária a importância da utilização de software, tanto para controle efetivo das receitas e despesas, como também para melhoria do do atendimento.

Efeitos do posicionamento e quantidade de prática mental na aprendizagem do arremesso do dardo de salão Effects of position and amount of mental practice in dart saloon throwing learning

Directory of Open Access Journals (Sweden)

Thábata Viviane Brandão Gomes

2012-06-01

Full Text Available A prática mental parece contribuir no processo de aprendizagem motora, mas ainda não estão claros os efeitos do posicionamento e da quantidade de prática mental em relação à prática física, sendo este o objetivo do presente estudo. Setenta e dois universitários de ambos os sexos e novatos na tarefa foram distribuídos em seis grupos de prática combinada (física e mental para a aprendizagem do arremesso do dardo de salão. Na fase de aquisição, os sujeitos realizaram 50 tentativas de prática física e 18, 90 ou 180 tentativas de prática mental (conforme cada grupo antes ou após a prática física. Dez minutos após a fase de aquisição foram realizados os testes de retenção e transferência. Não foi observada diferença significante entre os grupos nos testes. Os resultados indicaram que a quantidade e o posicionamento da prática mental não influenciaram a aprendizagem do arremesso do dardo de salão.Mental practice seems to contribute to the motor learning process but it is still not clear the effects of position and amount of mental practice in relation to physical practice, which was the aim of this study. Seventy two undergraduate students of both sexes and novice in the task were assigned in six groups of combined practice (physical and mental for learning the dart saloon throwing. In acquisition phase, subjects performed 50 trials of physical practice and 18, 90 or 180 trials of mental practice (according to each experimental group before or after physical practice. Ten minutes after acquisition phase it was performed retention and transfer tests. The results showed that amount and the position of mental practice did not influence dart saloon throwing learning.

Nagid: A re-examination in the light of the royal ideology in the ...

African Journals Online (AJOL)

p1243322

This article argues that nagid indicates divinely sanctioned leader of. Israel in 1 ... In the Saul tradition (1 Sm 9:1-10:16; 11:1-11) nagid signifies the leadership of ..... his subjects, a reticence that is characteristic of core Egyptian ideology, in.

Mitmevärvilised mõtisklused / Aita Kivi

Index Scriptorium Estoniae

Kivi, Aita, 1954-

2000-01-01

Sisu : Doris Lessing. Kuldne märkmeraamat; Rein Raud. Pisiasjad, mis omavad tähtsust; Italo Calvino. Palomar; Saul Bellow. Vihmakuningas Henderson; Danielle Steel. Rantsho; Margareta Strömstedt. Astrid Lindgren; Nicholas Davies. William - tulevane kuningas; Guntars Godinsh. Öö päike

2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside confers neuroprotection in cell and animal models of ischemic stroke through calpain1/PKA/CREB-mediated induction of neuronal glucose transporter 3

Energy Technology Data Exchange (ETDEWEB)

Yu, Shu; Cheng, Qiong; Li, Lu; Liu, Mei; Yang, Yumin; Ding, Fei, E-mail: dingfei@ntu.edu.cn

2014-06-15

Salidroside is proven to be a neuroprotective agent of natural origin, and its analog, 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside (named SalA-4 g), has been synthesized in our lab. In this study, we showed that SalA-4 g promoted neuronal survival and inhibited neuronal apoptosis in primary hippocampal neurons exposed to oxygen and glucose deprivation (OGD) and in rats subjected to ischemia by transient middle cerebral artery occlusion (MCAO), respectively, and that SalA-4 g was more neuroprotective than salidroside. We further found that SalA-4 g elevated glucose uptake in OGD-injured primary hippocampal neurons and increased the expression and recruitment of glucose transporter 3 (GLUT3) in ischemic brain. Signaling analysis revealed that SalA-4 g triggered the phosphorylation of CREB, and increased the expression of PKA RII in primary hippocampal neurons exposed to OGD injury, while inhibition of PKA/CREB by H-89 alleviated the elevation in glucose uptake and GLUT3 expression, and blocked the protective effects of SalA-4 g. Moreover, SalA-4 g was noted to inhibit intracellular Ca{sup 2+} influx and calpain1 activation in OGD-injured primary hippocampal neurons. Our results suggest that SalA-4 g neuroprotection might be mediated by increased glucose uptake and elevated GLUT3 expression through calpain1/PKA/CREB pathway. - Highlights: • A salidroside (Sal) analog (SalA-4 g) is prepared to be more neuroprotective than Sal. • SalA-4 g protected hippocampal neurons from oxygen and glucose deprivation insult. • SalA-4 g reduced ischemic injury after transient middle cerebral artery occlusion in rats. • Neuroprotection of SalA-4 g was mediated by GLUT3 level via calpain/PKA/CREB pathway.

2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside confers neuroprotection in cell and animal models of ischemic stroke through calpain1/PKA/CREB-mediated induction of neuronal glucose transporter 3

International Nuclear Information System (INIS)

Yu, Shu; Cheng, Qiong; Li, Lu; Liu, Mei; Yang, Yumin; Ding, Fei

2014-01-01

Salidroside is proven to be a neuroprotective agent of natural origin, and its analog, 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside (named SalA-4 g), has been synthesized in our lab. In this study, we showed that SalA-4 g promoted neuronal survival and inhibited neuronal apoptosis in primary hippocampal neurons exposed to oxygen and glucose deprivation (OGD) and in rats subjected to ischemia by transient middle cerebral artery occlusion (MCAO), respectively, and that SalA-4 g was more neuroprotective than salidroside. We further found that SalA-4 g elevated glucose uptake in OGD-injured primary hippocampal neurons and increased the expression and recruitment of glucose transporter 3 (GLUT3) in ischemic brain. Signaling analysis revealed that SalA-4 g triggered the phosphorylation of CREB, and increased the expression of PKA RII in primary hippocampal neurons exposed to OGD injury, while inhibition of PKA/CREB by H-89 alleviated the elevation in glucose uptake and GLUT3 expression, and blocked the protective effects of SalA-4 g. Moreover, SalA-4 g was noted to inhibit intracellular Ca 2+ influx and calpain1 activation in OGD-injured primary hippocampal neurons. Our results suggest that SalA-4 g neuroprotection might be mediated by increased glucose uptake and elevated GLUT3 expression through calpain1/PKA/CREB pathway. - Highlights: • A salidroside (Sal) analog (SalA-4 g) is prepared to be more neuroprotective than Sal. • SalA-4 g protected hippocampal neurons from oxygen and glucose deprivation insult. • SalA-4 g reduced ischemic injury after transient middle cerebral artery occlusion in rats. • Neuroprotection of SalA-4 g was mediated by GLUT3 level via calpain/PKA/CREB pathway

Showrunner

DEFF Research Database (Denmark)

Jensen, Mikkel Bo Brendstrup

2018-01-01

Redegørelse for begrebet "showrunner", der er en betegnelse for ledende manuskriptforfattere- og producenter i amerikansk tv-serieproduktion. Kendte eksempler er Jenji Kohan (Weeds, Orange is the New Black), Vince Gilligan (Breaking Bad, Better Call Saul), Shonda Rhimes (Grey’s Anatomy, Scandal) og...

Salting kinetics and salt diffusivities in farmed Pantanal caiman muscle Cinética de salga e difusividades de sal em carne de jacaré do Pantanal criado em cativeiro

Directory of Open Access Journals (Sweden)

Vânia Regina Nicoletti Telis

2003-04-01

Full Text Available The legal Pantanal caiman (Caiman crocodilus yacare farming, in Brazil, has been stimulated and among meat preservation techniques the salting process is a relatively simple and low-cost method. The objective of this work was to study the sodium chloride diffusion kinetics in farmed caiman muscle during salting. Limited volumes of brine were employed, with salting essays carried at 3, 4 and 5 brine/muscle ratios, at 15%, 20% and 25% w/w brine concentrations, and brine temperatures of 10, 15 and 20ºC. The analytical solution of second Fick's law considering one-dimensional diffusion through an infinite slab in contact with a well-stirred solution of limited volume was used to calculate effective salt diffusion coefficients and to predict the sodium chloride content in the fillets. A good agreement was obtained between the considered analytical model and experimental data. Salt diffusivities in fillets were found to be in the range of 0.47x10-10 to 9.62x10-10 m²/s.A criação de jacaré do Pantanal (Caiman crocodilus yacare em cativeiro tem sido estimulada, e entre as técnicas de processamento de sua carne, a salga é um processo de conservação relativamente simples e de baixo custo. O objetivo deste trabalho foi estudar a cinética de difusão de cloreto de sódio em carne de jacaré do Pantanal criado em cativeiro, durante a salga úmida. Foram utilizados volumes limitados de salmoura e os experimentos foram realizados com relações salmoura/músculo de 3, 4 e 5, com concentrações de salmoura de 15%, 20% e 25% em peso e temperaturas de 10, 15 e 20ºC. A solução analítica da segunda lei de Fick, considerando difusão unidimensional em uma placa infinita em contato com uma solução bem agitada de volume limitado, foi utilizada para calcular os coeficientes de difusão efetivos de sal e estimar o conteúdo de cloreto de sódio nos filés. Obteve-se boa concordância entre o modelo analítico considerado e os dados experimentais. As

Relación costo-utilidad de la disminución del consumo de sal y su efecto en la incidencia de enfermedades cardiovasculares en Argentina The cost-utility ratio of reducing salt intake and its impact on the incidence of cardiovascular disease in Argentina

Directory of Open Access Journals (Sweden)

Daniel Ferrante

2012-10-01

Full Text Available OBJETIVO: Estimar la relación costo-utilidad de una intervención dirigida a reducir el consumo de sal en la dieta de personas mayores de 35 años en Argentina. MÉTODOS: La intervención consistió en reducir entre 5% y 25% el contenido de sal en los alimentos. Se utilizó el modelo de simulación del impacto de las políticas sobre la enfermedad coronaria para predecir la evolución de la incidencia, la prevalencia, la mortalidad y los costos en la población de la enfermedad coronaria y cerebrovascular en personas de 35 a 84 años. Se modeló el efecto y los costos de una disminución de 3 g de sal en la dieta, mediante su reducción en alimentos procesados y en la añadida por los consumidores, por un período de 10 años. Se estimó el cambio en la ocurrencia de eventos en este período y la ganancia en años de vida ajustados por la calidad (AVAC en un escenario de efecto alto y otro de efecto bajo. RESULTADOS: La intervención generó un ahorro neto de US$ 3 765 millones y una ganancia de 656 657 AVAC en el escenario de efecto alto y de US$ 2 080 millones y 401 659 AVAC en el escenario de efecto bajo. Se obtendrían reducciones en la incidencia de enfermedad coronaria (24,1%, infarto agudo de miocardio (21,6% y accidente cerebrovascular (20,5%, y en la mortalidad por enfermedad coronaria (19,9% y por todas las causas (6,4%. Se observaron beneficios para todos los grupos de edad y sexo. CONCLUSIONES: La implementación de esta estrategia de reducción del consumo de sal produciría un efecto sanitario muy positivo, tanto en AVAC ganados como en recursos económicos ahorrados.OBJECTIVE: Estimate the cost-utility ratio of an intervention to reduce dietary salt intake in people over the age of 35 in Argentina. METHODS: The intervention consisted of reducing salt content in food by 5% to 25%. A simulation model was used to measure the impact of policies on heart disease in order to predict incidence, prevalence, mortality, and cost trends for

Produção leiteira, composição do leite e perfil bioquímico sanguíneo de vacas lactantes sob suplementação com sal aniônico Milk yield, milk composition and biochemical blood profile of lactating cows supplemented with anionic salt

Directory of Open Access Journals (Sweden)

Lúcia Treptow Marques

2011-05-01

Full Text Available Objetivou-se avaliar os efeitos da inclusão de sal aniônico na dieta sobre as características físicas e a composição química do leite, o perfil bioquímico sanguíneo, a produção de leite, o peso e a condição corporal de vacas em lactação. Foram utilizadas 20 vacas da raça Jersey distribuídas em duas dietas, uma sem adição de sal aniônico e outra com adição de 0,25 kg/dia de cloreto de amônio. O delineamento empregado foi o completamente casualizado. As vacas sob suplementação com sal aniônico apresentaram menor pH urinário e aumento das concentrações sanguíneas de ureia, cálcio e magnésio. Com a dieta aniônica, o leite precipitou com menores concentrações de etanol, apresentou menor densidade, porcentagens de lactose, proteína e imunoglobulina, porém maior teor de cálcio iônico. O fornecimento de dieta aniônica durante a lactação resultou em acidose metabólica, o que alterou o perfil bioquímico sanguíneo e as características físico-químicas do leite.The objective of this work was to evaluate the inclusion of anionic salt in the diet on the physical characteristics and chemical composition of milk, biochemical blood profile, milk yield, body weight and condition. It was used 20 Jersey cows, distributed into two diets, a diet with no addition of anionic salt and one diet with addition of 0.25 kg/day of ammonium chloride. It was used a completely randomized design. Cows supplemented with anionic salt presented lower urinary pH and increase of blood contents of urea, calcium and magnesium. With the anionic diet, milk precipitated with lower ethanol concentration and it presented lower density, percentages of lactose, protein and immunoglobulin, but higher ionic calcium content. Supply of anionic diet during lactation resulted in metabolic acidosis, which altered the blood biochemical profile and milk physical-chemical characteristics.

Study of Wide Swath Synthetic Aperture Ladar Imaging Techology

Directory of Open Access Journals (Sweden)

Zhang Keshu

2017-02-01

Full Text Available Combining synthetic-aperture imaging and coherent-light detection technology, the weak signal identification capacity of Synthetic Aperture Ladar (SAL reaches the photo level, and the image resolution exceeds the diffraction limit of the telescope to obtain high-resolution images irrespective to ranges. This paper introduces SAL, including the development path, technology characteristics, and the restriction of imaging swath. On the basis of this, we propose to integrate the SAL technology for extending its swath. By analyzing the scanning-operation mode and the signal model, the paper explicitly proposes that the former mode will be the developmental trend of the SAL technology. This paper also introduces the flight demonstrations of the SAL and the imaging results of remote targets, showing the potential of the SAL in long-range, high-resolution, and scanning-imaging applications. The technology and the theory of the scanning mode of SAL compensates for the defects related to the swath and operation efficiency of the current SAL. It provides scientific foundation for the SAL system applied in wide swath, high resolution earth observation, and the ISAL system applied in space-targets imaging.

Comparative Genomics and Transcriptional Analysis of Prophages Identified in the Genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei†

Science.gov (United States)

Ventura, Marco; Canchaya, Carlos; Bernini, Valentina; Altermann, Eric; Barrangou, Rodolphe; McGrath, Stephen; Claesson, Marcus J.; Li, Yin; Leahy, Sinead; Walker, Carey D.; Zink, Ralf; Neviani, Erasmo; Steele, Jim; Broadbent, Jeff; Klaenhammer, Todd R.; Fitzgerald, Gerald F.; O'Toole, Paul W.; van Sinderen, Douwe

2006-01-01

Lactobacillus gasseri ATCC 33323, Lactobacillus salivarius subsp. salivarius UCC 118, and Lactobacillus casei ATCC 334 contain one (LgaI), four (Sal1, Sal2, Sal3, Sal4), and one (Lca1) distinguishable prophage sequences, respectively. Sequence analysis revealed that LgaI, Lca1, Sal1, and Sal2 prophages belong to the group of Sfi11-like pac site and cos site Siphoviridae, respectively. Phylogenetic investigation of these newly described prophage sequences revealed that they have not followed an evolutionary development similar to that of their bacterial hosts and that they show a high degree of diversity, even within a species. The attachment sites were determined for all these prophage elements; LgaI as well as Sal1 integrates in tRNA genes, while prophage Sal2 integrates in a predicted arginino-succinate lyase-encoding gene. In contrast, Lca1 and the Sal3 and Sal4 prophage remnants are integrated in noncoding regions in the L. casei ATCC 334 and L. salivarius UCC 118 genomes. Northern analysis showed that large parts of the prophage genomes are transcriptionally silent and that transcription is limited to genome segments located near the attachment site. Finally, pulsed-field gel electrophoresis followed by Southern blot hybridization with specific prophage probes indicates that these prophage sequences are narrowly distributed within lactobacilli. PMID:16672450

The Correlation Between Porosity, Density and Degree of Serpentinization in Ophiolites from Point Sal, California: Implications for Strength of Oceanic Lithosphere

Science.gov (United States)

Karrasch, A. K.; Farough, A.; Lowell, R. P.

2017-12-01

Hydration and serpentinization of oceanic lithosphere influences its strength and behavior under stress. Serpentine content is the limiting factor in deformation and the correlation between crustal strength and the degree of serpentinization is not linear. Escartin et al., [2001] shows that the presence of only 10% serpentine results in a nominally non-dilatant mode of brittle deformation and reduces the strength of peridotites dramatically. In this study, we measured density and porosity of ophiolite samples from Point Sal, CA that had various degrees of serpentinization. The densities ranged between 2500- 3000 kg/m3 and porosities ranged between 2.1-4.8%. The degree of serpentinization was estimated from mineralogical analysis, and these data were combined with that of 4 other samples analyzed by Farough et al., [2016], which were obtained from various localities. The degree of serpentinization varied between 0.6 and 40%. We found that degree of serpentinization was inversely correlated with density with a slope of 7.25 (kg/m3)/%. Using Horen et al., [1996] models, estimated P-wave velocity of the samples ranged between 6.75-7.90 km/s and S-wave velocity ranged between 3.58-4.35 km/s. There were no distinguishable difference in the results between olivine-rich or pyroxene-rich samples. These results, along with correlations to strength and deformation style, can be used as a reference for mechanical properties of the crust at depth, analysis of deep drill cores and to estimate the rate of weakening of the oceanic crust after the onset of serpentinization reactions.

Problem Davranışların Azaltılmasında Olumlu Davranışsal Destek Planı Hazırlama

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Dilek Erbaş

2002-07-01

Full Text Available Günümüzde problem davranışlara, normal gelişim gösteren ve özürlü çocuklarda oldukça sık rastlanılmaktadır. Problem davranışlar öğrencilerin yaşamlarını farklı şekillerde olumsuz olarak etkilemekledir. Problem davranış gösteren bireyler bit davranışları nedeniyle, eğitim ve öğretim olanaklarından yeterince yararlanamamaktadır. Ayrıca, bu bireyler akranları ve toplumdaki diğer bireyler tarafından dışlanabildikleri için bazı sosyal becerileri geliştirememekle ya da sınırlı düzeyde geliştirebilmekledirler. Dolayısıyla, öğretmenler, öğrencilerin yaşamlarını olumsuz etkileyen bu davranışları azaltmak için, olumlu davranışsal destek planı hazırlamalıdır. Hazırlanan bu planlar, uygulamalı davranış analiz ilkelerine dayalı olmalıdır. Ayrıca, hazırlanan planın Öğrenciye ve uygulayacak bireylerin değer yargılarına uygun olması gereklidir. Olumlu davranışsal destek planının sahip olması gereken diğer önemli bir özelliği ise, hazırlanan planın. Öğrencinin yaşam kalitesini arttıracak şekilde desenlenınesi ve uygulanmasıdır. Kapsamlı bir plan hazırlamak için, planı ayrıntılı şekilde yazmak, tutarlı ve sistemli olarak uygulamak ve planın etkililiğini değerlendirmek ve gerektiğinde düzenlemeleri yapmak için veri toplamak gibi basamakları gerçekleştirmek gereklidir. Problem behaviors are frequently seen among the children with normal development as well as children with disabilities- Problem behaviors affect the students' lives in different negative ways. Individuals exhibiting problem behaviors cannot make the most out of their educational opportunities due to their behaviors. What's more, these individuals may run the risk of being incompetent or restricted İn some social skills because of being excluded by their peers. Thus, teachers should prepare behavior-changing plans based on positive behavior support to mitigate the problem behaviors

On the nature of T(Al2Mg3Zn3) and S(Al2CuMg) phases present in as-cast and annealed 7055 aluminum alloy

International Nuclear Information System (INIS)

Mondal, Chandan; Mukhopadhyay, A.K.

2005-01-01

Aluminum alloys, encompassed by AA 7055 alloy composition, having the nominal zinc content (i.e. 8 wt.%) but varying copper and magnesium contents across the alloy composition range were examined in the as-cast form by a combination of light microscopy, scanning electron microscopy (SEM), electron probe micro analysis (EPMA) and X-ray diffraction (XRD). It is observed that for all compositions, the second phases based on η(MgZn 2 ), T(Al 2 Mg 3 Zn 3 ) and S(Al 2 CuMg) are present. The T phase dissolves copper up to 28 wt.%, whilst the S phase shows metastable solubility of zinc that may range up to 30 wt.%. In alloys with magnesium at the lower limit and the copper contents approaching the upper limit of the alloy composition, the θ phase (Al 2 Cu) of the constituent binary Al-Cu system is further observed. The θ phase (Al 2 Cu) does not dissolve either zinc or magnesium. Below the nominal composition, the alloys could be homogenized substantially using a commercially viable homogenization treatment leaving small amounts of undissolved S phase that does not contain any zinc

Om te staak of nie te staak nie? Die sieninge van 'n aantal swart ...

African Journals Online (AJOL)

Erna Kinsey

sig, is eerstens om ondersoek in te stel na 'n groep swart opvoeders se sieninge oor opvoeders se reg om te staak. Tweedens sal na die redes wat hierdie opvoeders aanvoer waarom hulle al aan stakings deel- geneem het of sal deelneem, gelet word. Derdens sal die redes waarom sommige opvoeders nie sal staak nie, ...

Low Amount of Salinomycin Greatly Increases Akt Activation, but Reduces Activated p70S6K Levels

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Sungpil Yoon

2013-08-01

Full Text Available The present study identified a novel salinomycin (Sal-sensitization mechanism in cancer cells. We analyzed the signal proteins Akt, Jnk, p38, Jak, and Erk1/2 in cancer cell lines that had arrested growth following low amounts of Sal treatment. We also tested the signal molecules PI3K, PDK1, GSK3β, p70S6K, mTOR, and PTEN to analyze the PI3K/Akt/mTOR pathway. The results showed that Sal sensitization positively correlates with large reductions in p70S6K activation. Interestingly, Akt was the only signal protein to be significantly activated by Sal treatment. The Akt activation appeared to require the PI3K pathway as its activation was abolished by the PI3K inhibitors LY294002 and wortmannin. The Akt activation by Sal was conserved in the other cell lines analyzed, which originated from other organs. Both Akt activation and C-PARP production were proportionally increased with increased doses of Sal. In addition, the increased levels of pAkt were not reduced over the time course of the experiment. Co-treatment with Akt inhibitors sensitized the Sal-treated cancer cells. The results thereby suggest that Akt activation is increased in cells that survive Sal treatment and resist the cytotoxic effect of Sal. Taken together; these results indicate that Akt activation may promote the resistance of cancer cells to Sal.

Sodio y medicamentos

OpenAIRE

Satué de Velasco, Eduardo

2011-01-01

Leyendo el Volumen 2 número 4 de la revista, he visto la interesantísima revisión sobre la sal en analgésicos efervescentes del doctor Martínez1. Quisiera felicitar al autor, ya que incide en muchos puntos fundamentales: impacto de la sal en la hipertensión arterial (HTA), el factor sal-sensible/sal-resistente, estrategia de la Organización Mundial de la Salud (OMS) acerca del consumo de sal, contenido de sodio de los distintos analgésicos efervescentes, la importancia de evitar su consumo en...

Uso do rejeito da dessalinização de água salobra para irrigação da erva-sal (Atriplex nummularia The use of the brine from desalting brackish water to irrigate saltbush (Atriplex nummularia

Directory of Open Access Journals (Sweden)

Everaldo R. Porto

2001-04-01

Full Text Available Com o objetivo de se reduzir os impactos causados pela dessalinização de água salobra proveniente do cristalino no trópico semi-árido brasileiro, a erva-sal (Atriplex nummularia foi cultivada durante um ano, nos campos da Estação Experimental da Embrapa Semi-Árido. As plantas foram irrigadas com rejeito do processo de dessalinização, com concentração salina média de 11,38 dS m-1, e cada uma recebeu 75 L de água por semana, durante 48 semanas. A salinidade média do perfil de solo, da camada de 0 a 90 cm, era de 0,64 dS m-1 antes de se iniciar a irrigação das plantas; depois da colheita das plantas, a salinidade do mesmo perfil de solo foi de 12,74 dS m-1, enquanto a produtividade da erva-sal foi de 6.537,0 kg ha-1 de matéria seca, com teor de proteína bruta de 18,40% nas folhas. A Atriplex apresentou grande potencial de extração de sais do perfil de solo, mas quando as plantas são irrigadas com rejeito de alta concentração salina, a quantidade de sais extraída desse perfil pela planta, é da ordem de 3,93% do total de sais adicionados ao solo pelas irrigações; isto implica no fato de que, para um manejo de água sustentável, há necessidade de se gerar mais informações sobre as relações de solo e água para a erva-sal, nas condições das zonas áridas do Brasil.Looking forward to reducing environmental impacts resulting from desalting brackish water in the region of the crystalline rocks in the semi-arid tropic of Brazil, saltbush (Atriplex nummularia was cultivated during one year in an experimental field of Embrapa Semi-Arid. The plants were irrigated with the brine from the desalting plant which presented a salt concentration of 11.38 dS m-1. Each plant received 75 L of water per week, during 48 weeks. The soil salinity, at the depth of 0-90 cm, of the cropped area averaged 0.64 dS m-1 before starting the irrigation process. After the plants were harvested, the soil salinity in the same profile averaged 12.74 d

Polymerization reactivity of sulfomethylated alkali lignin modified with horseradish peroxidase.

Science.gov (United States)

Yang, Dongjie; Wu, Xiaolei; Qiu, Xueqing; Chang, Yaqi; Lou, Hongming

2014-03-01

Alkali lignin (AL) was employed as raw materials in the present study. Sulfomethylation was conducted to improve the solubility of AL, while sulfomethylated alkali lignin (SAL) was further polymerized by horseradish peroxidase (HRP). HRP modification caused a significant increase in molecular weight of SAL which was over 20 times. It was also found to increase the amount of sulfonic and carboxyl groups while decrease the amount of phenolic and methoxyl groups in SAL. The adsorption quantity of self-assembled SAL film was improved after HRP modification. Sulfonation and HRP modification were mutually promoted. The polymerization reactivity of SAL in HRP modification was increased with its sulfonation degree. Meanwhile, HRP modification facilitated SAL's radical-sulfonation reaction. Copyright © 2014. Published by Elsevier Ltd.

Layò ÒGÚNLO LÁ Abstract Singing has become

African Journals Online (AJOL)

love people have for singing is so great that we can relate it to the Yorùbá saying: “etí were ni .... Page 5 .... Singing and dancing to meet King Saul with tumbrels, with song .... heaven… Mr. Driver, limit your speed/2times. Life has no duplicate.

Supernova Cosmology Project

Science.gov (United States)

, i.e. with the cosmology hidden. Looking Beyond Lambda with the Union Supernova Compilation by Rubin et Matrix Description Covariance Matrix with Systematics Description Full Table of All SNe Description Beyond Lambda Figures Updated 11-18-11 Contact: drubin at physics dot fsu dot edu, saul at lbl dot gov

Two Adolescents at Risk for Schizophrenia: A Family Case Study.

Science.gov (United States)

Taichert, Louise C.

1979-01-01

Studies complex factors contributing to the development of adolescent psychoses in two stepbrothers. Neurodevelopmental difficulties make them vulnerable to their parents' fears and conflicts. This affects the quality of their total life experience and the kind of parent-child relationships leading to their psychoses. A discussion by Saul L. Brown…

Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors.

Science.gov (United States)

Gianlorenço, A C L; Canto-de-Souza, A; Mattioli, R

2013-12-17

Studies have demonstrated the relationship between the histaminergic system and the cerebellum, and we intend to investigate the role of the cerebellar histaminergic system on memory consolidation. This study investigated the effect of intra-cerebellar microinjection of histamine on memory retention of inhibitory avoidance in mice, and the role of H1 and H2 receptors in it. The cerebellar vermis of male mice were implanted with guide cannulae, and after three days of recovery, the inhibitory avoidance test was performed. Immediately after a training session, animals received a microinjection of histaminergic drugs: in the experiment 1, saline (SAL) or histamine (HA 0.54, 1.36, 2.72 or 4.07 nmol); experiment 2, SAL or 1.36 nmol HA 5 min after a pretreatment with 0.16 nmol chlorpheniramine (CPA) or SAL; and experiment 3, SAL or 1.36 nmol HA 5 min after a pretreatment with 2.85 nmol ranitidine (RA) or SAL. Twenty-four hours later, a retention test was performed. The data were analyzed using one-way analysis of variance (ANOVA) and Duncan's tests. In experiment 1, animals microinjected with 1.36 nmol HA showed a higher latency to cross to the dark compartment compared to controls and to 2.72 and 4.07 nmol HA groups. In experiment 2, the combined infusions revealed difference between control (SAL+SAL) and SAL+HA and CPA+HA; while in the experiment 3 the analysis indicated differences in retention latency between mice injected with SAL+SAL and SAL+HA. The groups that received the H2 antagonist RA did not show difference compared to control. These results indicate that 1.36 nmol HA enhances memory consolidation of inhibitory avoidance learning in mice and that the pretreatment with H2 antagonist RA was able to prevent this effect. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol.

Science.gov (United States)

Murata, Mariko; Midorikawa, Kaoru; Kawanishi, Shosuke

2013-10-21

Drinking alcohol is a risk factor for breast cancer. Salsolinol (SAL) is endogenously formed by a condensation reaction of dopamine with acetaldehyde, a major ethanol metabolite, and SAL is detected in blood and urine after alcohol intake. We investigated the possibility that SAL can participate in tumor initiation and promotion by causing DNA damage and cell proliferation, leading to alcohol-associated mammary carcinogenesis. SAL caused oxidative DNA damage including 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), in the presence of transition metal ions, such as Cu(II) and Fe(III)EDTA. Inhibitory effects of scavengers on SAL-induced DNA damage and the electron spin resonance study indicated the involvement of H₂O₂, which is generated via the SAL radical. Experiments on scavengers and site specificity of DNA damage suggested ·OH generation via a Fenton reaction and copper-peroxide complexes in the presence of Fe(III)EDTA and Cu(II), respectively. SAL significantly increased 8-oxodG formation in normal mammary epithelial MCF-10A cells. In addition, SAL induced cell proliferation in estrogen receptor (ER)-negative MCF-10A cells, and the proliferation was inhibited by an antioxidant N-acetylcysteine and an epidermal growth factor receptor (EGFR) inhibitor AG1478, suggesting that reactive oxygen species may participate in the proliferation of MCF-10A cells via EGFR activation. Furthermore, SAL induced proliferation in estrogen-sensitive breast cancer MCF-7 cells, and a surface plasmon resonance sensor revealed that SAL significantly increased the binding activity of ERα to the estrogen response element but not ERβ. In conclusion, SAL-induced DNA damage and cell proliferation may play a role in tumor initiation and promotion of multistage mammary carcinogenesis in relation to drinking alcohol.

Salinomycin inhibits metastatic colorectal cancer growth and interferes with Wnt/β-catenin signaling in CD133+ human colorectal cancer cells

International Nuclear Information System (INIS)

Klose, Johannes; Eissele, Jana; Volz, Claudia; Schmitt, Steffen; Ritter, Alina; Ying, Shen; Schmidt, Thomas; Heger, Ulrike; Schneider, Martin; Ulrich, Alexis

2016-01-01

The polyether antibiotic Salinomycin (Sal) is regarded as an inhibitor of cancer stem cells. Its effectiveness on human colorectal cancer (CRC) cells in vitro has been demonstrated before. The aim of this study was to establish a murine model to investigate the effectiveness of Sal in vivo. Furthermore, we investigated the impact of Sal on Wnt/β-catenin signaling in human CD133 + CRC cells. The two murine CRC cell lines MC38 and CT26 were used to analyze the impact of Sal on tumor cell proliferation, viability, migration, cell cycle progression and cell death in vitro. For in vivo studies, CT26 cells were injected into syngeneic BALB/c mice to initiate (i) subcutaneous, (ii) orthotopic, or (iii) metastatic CRC growth. Sal was administered daily, 5-Fluoruracil served as a control. For mechanistic studies, the CD133 + and CD133 - subpopulations of human CRC cells were separated by flow cytometry and separately exposed to increasing concentrations of Sal. The impact on Wnt/β-catenin signaling was determined by Western blotting and quantitative PCR. Sal markedly impaired tumor cell viability, proliferation and migration, and induced necrotic cell death in vitro. CRC growth in vivo was likewise inhibited upon Sal treatment. Interference with Wnt signaling and reduced expression of the Wnt target genes Fibronectin and Lgr5 indicates a novel molecular mechanism, mediating anti-tumoral effects of Sal in CRC. Sal effectively impairs CRC growth in vivo. Furthermore, Sal acts as an inhibitor of Wnt/β-catenin signaling. Thus, Salinomycin represents a promising candidate for clinical CRC treatment. The online version of this article (doi:10.1186/s12885-016-2879-8) contains supplementary material, which is available to authorized users

Role of lipase from community-associated methicillin-resistant Staphylococcus aureus strain USA300 in hydrolyzing triglycerides into growth-inhibitory free fatty acids.

Science.gov (United States)

Cadieux, Brigitte; Vijayakumaran, Vithooshan; Bernards, Mark A; McGavin, Martin J; Heinrichs, David E

2014-12-01

Part of the human host innate immune response involves the secretion of bactericidal lipids on the skin and delivery of triglycerides into abscesses to control invading pathogens. Two Staphylococcus aureus lipases, named SAL1 and SAL2, were identified in the community-associated methicillin-resistant S. aureus strain USA300, which, presumably, are produced and function to degrade triglycerides to release free fatty acids. We show that the SAL2 lipase is one of the most abundant proteins secreted by USA300 and is proteolytically processed from the 72-kDa proSAL2 to the 44-kDa mature SAL2 by the metalloprotease aureolysin. We show that spent culture supernatants had lipase activity on both short- and long-chain fatty acid substrates and that deletion of gehB, encoding SAL2, resulted in the complete loss of these activities. With the use of gas chromatography-mass spectrometry, we show that SAL2 hydrolyzed trilinolein to linoleic acid, a fatty acid with known antistaphylococcal properties. When added to cultures of USA300, trilinolein and, to a lesser extent, triolein inhibited growth in a SAL2-dependent manner. This effect was shown to be due to the enzymatic activity of SAL2 on these triglycerides, since the catalytically inactive SAL2 Ser412Ala mutant was incapable of hydrolyzing the triglycerides or yielding delayed growth in their presence. Overall, these results reveal that SAL2 hydrolyzes triglycerides of both short- and long-chain fatty acids and that the released free fatty acids have the potential to cause significant delays in growth, depending on the chemical nature of the free fatty acid. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-γ and LXRα

Energy Technology Data Exchange (ETDEWEB)

Yue, Jianmei [Department of Endocrinology, Shandong Province Hospital Affiliated to Shandong University, 324# Jing 5 Road, Jinan 255021 (China); Department of Endocrinology, The First Hospital of Zibo, 4# E Mei Shan Dong Road, Zibo 255200 (China); Li, Bo, E-mail: libosubmit@163.com [Department of Cardiology, Central Hospital of Zibo, 54# Gong Qing Tuan Xi Road, Zibo, Shandong Province (China); Jing, Qingping [Department of Endocrinology, The First Hospital of Zibo, 4# E Mei Shan Dong Road, Zibo 255200 (China); Guan, Qingbo, E-mail: guanqingbosubmit@163.com [Department of Endocrinology, Shandong Province Hospital Affiliated to Shandong University, 324# Jing 5 Road, Jinan 255021 (China)

2015-07-03

Objectives: Cholesterol efflux has been thought to be the main and basic mechanism by which free cholesterol is transferred from extra hepatic cells to the liver or intestine for excretion. Salvianolic acid B (Sal B) has been widely used for the prevention and treatment of atherosclerotic diseases. Here, we sought to investigate the effects of Sal B on the cholesterol efflux in THP-1 macrophages. Methods: After PMA-stimulated THP-1 cells were exposed to 50 mg/L of oxLDL and [{sup 3}H] cholesterol (1.0 μCi/mL) for another 24 h, the effect of Sal B on cholesterol efflux was evaluated in the presence of apoA-1, HDL{sub 2} or HDL{sub 3}. The expression of ATP binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-gamma (PPAR-γ), and liver X receptor-alpha (LXRα) was detected both at protein and mRNA levels in THP-1 cells after the stimulation of Sal B. Meanwhile, specific inhibition of PPAR-γ and LXRα were performed to investigate the mechanism. Results: The results showed that Sal B significantly accelerated apoA-I- and HDL-mediated cholesterol efflux in both dose- and time-dependent manners. Meanwhile, Sal B treatment also enhanced the expression of ABCA1 at both mRNA and protein levels. Then the data demonstrated that Sal B increased the expression of PPAR-γ and LXRα. And the application of specific agonists and inhibitors of further confirmed that Sal exert the function through PPAR-γ and LXRα. Conclusion: These results demonstrate that Sal B promotes cholesterol efflux in THP-1 macrophages through ABCA1/PPAR-γ/LXRα pathway. - Highlights: • Sal B promotes the expression of ABCA1. • Sal B promotes cholesterol efflux in macrophages. • Sal B promotes the expression of ABCA1 and cholesterol efflux through PPAR-γ/LXRα signaling pathway.

An Analysis of the Distinction between Deep and Shallow Expert Systems

Science.gov (United States)

1989-08-01

Standards Yorktown Heighta, NY 10500 Gaithersburg, MD 20896 Dr. Saul Amarel Dept. of Computer Science Dr. Harold Bamford CDR Robert Carter Rutgero...Michigan Marina Del Ray, CA 00232 320 Packard Read Ann Arbor, MI 48103 Mr. Colin Sheppard Dr. Diana We.r-e AXC2 Block I Mr. Prasad Tadepalli Department of

Détection de souches multi-résistantes d’Escherichia coli d’origine aviaire dans la région de Rabat-Salé-Zemmour-Zaer

Directory of Open Access Journals (Sweden)

N. RAHMATALLAH

2017-05-01

Full Text Available Antimicrobial resistance surveillance is a standard measure in the sanitary policies. In order to monitor multi-resistance within APEC strains, a study was conducted on 370 broiler chickens farms from the Rabat-Salé-Zemmour-Zaer region in Morocco. The isolation of Escherichia coli was made from lesions of avian colibacillosis. Biochemical identification, serotyping and antimicrobial susceptibility tests as well as phenotypic identifications on lactamases resistance were carried out on the isolates. Serogrouping showed that 66.7 % of the isolates belong to the dominant serotypes O78, O 2 and O1. Drug sensitivity tests showed extremely high levels of resistance to oxytetracyclin (100 %, amoxicillin (90.9%, trimethoprim + sulphamethoxazol (82.2 %, enrofloxacin (75.9 % and florfenicol (61.5 %. Low frequencies of resistances were noted for gentamicin (24.8 %, fosfomycin (16.1 % and colistin (2%. In parallel, tests for the determination of the phenotype of resistance to beta-lactamases and cephalosporinases on 250 strains revealed that 66.1% of the strains were classified as class A penicillinases; 14.8% were class C cephalosporinases. The ESBL class A was found in 11.1% of the tested stains and only 3.7% were classified as wild-type strains. The multi-resistance is very high since 97.4% and 55.1% of the strains were respectively resistant to three and five antibacterial drugs.

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway

Directory of Open Access Journals (Sweden)

Wei Zhang

2016-01-01

Full Text Available The degenerative loss through apoptosis of dopaminergic neurons in the substantia nigra pars compacta plays a primary role in the progression of Parkinson’s disease (PD. Our in vitro experiments suggested that salidroside (Sal could protect against 1-methyl-4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3β pathway. The current study aims to increase our understanding of the protective mechanisms of Sal in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine- (MPTP- induced PD mouse model. We found that pretreatment with Sal could protect against MPTP-induced increase of the time of turning downwards and climbing down to the floor. Sal also prevented MPTP-induced decrease of locomotion frequency and the increase of the immobile time. Sal provided a protection of in MPTP-induced loss of tyrosine hydroxylase-positive neurons in SNpc and the level of DA, DOPAC, and HVA in the striatum. Furthermore, Sal could increase the phosphorylation level of Akt and GSK3β, upregulate the ratio of Bcl-2/Bax, and inhibit the activation of caspase-3, caspase-6, and caspase-9. These results show that Sal prevents the loss of dopaminergic neurons and the PI3K/Akt/GSK3β pathway signaling pathway may have mediated the protection of Sal against MPTP, suggesting that Sal may be a potential candidate in neuroprotective treatment for PD.

What's Pragmatic about Community Organizing?

Science.gov (United States)

Abowitz, Kathleen Knight

2010-01-01

In the last decade, educational researchers and scholars have turned new attention to the theory and practice of community organizing as a method for addressing education injustices. While there are diverse traditions of community organizing work, by far the most influential model in US contexts is that of Saul Alinsky, whose "Rules for Radicals"…

Teachers' Study Guide: The American Jewish Writer. The Image of the Jew in Literature.

Science.gov (United States)

Mersand, Joseph; Zara, Louis

This guide was prepared to give an historical as well as a contemporary perspective on American Jewish authors and their writings. An introductory section presents information on such authors as Saul Bellow, Bernard Malamud, and Philip Roth; on the unique problems which Jewish writers have encountered in America; and on the breadth of current…

Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice

Energy Technology Data Exchange (ETDEWEB)

Xu, Xiaomei; Hu, Yan; Zhai, Xiaohan; Lin, Musen [Department of Pharmacology, Dalian Medical University, Dalian 116044 (China); Chen, Zhao; Tian, Xiaofeng; Zhang, Feng [Department of General Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian 116023 (China); Gao, Dongyan; Ma, Xiaochi [Department of Pharmacology, Dalian Medical University, Dalian 116044 (China); Lv, Li, E-mail: lv_li@126.com [Department of Pharmacology, Dalian Medical University, Dalian 116044 (China); Yao, Jihong, E-mail: Yaojihong65@hotmail.com [Department of Pharmacology, Dalian Medical University, Dalian 116044 (China)

2013-11-15

Salvianolic acid A (SalA) is a phenolic carboxylic acid derivative extracted from Salvia miltiorrhiza. It has many biological and pharmaceutical activities. The purpose of this study was to investigate the effect of SalA on concanavalin A (ConA)-induced acute hepatic injury in Kunming mice and to explore the role of SIRT1 in such an effect. The results showed that in vivo pretreatment with SalA significantly reduced ConA-induced elevation in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and decreased levels of the hepatotoxic cytokines such as interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α). Moreover, the SalA pretreatment ameliorated the increases in NF-κB and in cleaved caspase-3 caused by ConA exposure. Whereas, the pretreatment completely reversed expression of the B-cell lymphoma-extra large (Bcl-xL). More importantly, the SalA pretreatment significantly increased the expression of SIRT1, a NAD{sup +}-dependent deacetylase, which was known to attenuate acute hypoxia damage and metabolic liver diseases. In our study, the increase in SIRT1 was closely associated with down-regulation of the p66 isoform (p66shc) of growth factor adapter Shc at both protein and mRNA levels. In HepG2 cell culture, SalA pretreatment increased SIRT1 expression in a time and dose-dependent manner and such an increase was abrogated by siRNA knockdown of SIRT1. Additionally, inhibition of SIRT1 significantly reversed the decreased expression of p66shc, and attenuated SalA-induced p66shc down-regulation. Collectively, the present study indicated that SalA may be a potent activator of SIRT and that SalA can alleviate ConA-induced hepatitis through SIRT1-mediated repression of the p66shc pathway. - Highlights: • We report for the first time that SalA protects against ConA-induced hepatitis. • We find that SalA is a potential activator of SIRT1. • SalA's protection against hepatitis involves SIRT1-mediated repression of p

Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation

Directory of Open Access Journals (Sweden)

Guifen Qiang

2015-05-01

Full Text Available Background/Aims: Diabetes mellitus (DM characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which is a traditional Chinese medicine widely used to treat cardiovascular diseases. However, little is known about its antidiabetic effect. Our study aimed to investigate the in vivo and in vitro antidiabetic effect of SalA and the underlying mechanisms. Methods: Alloxan-induced type 1 diabetic mice and high-fat diet (HFD and low-dose streptozotocin (STZ-induced type 2 diabetic rats received SalA treatment. Blood glucose, oral glucose tolerance test (OGTT, 24-h food and water intake were monitored. In vitro, glucose consumption and uptake were measured in HepG2 cells and L6 myotubes. Mitochondrial function was detected in hepatic and skeletal muscle mitochondria. AMP-activated protein kinase (AMPK and Akt were analyzed by western blot. Results: In both type 1 and type 2 diabetic animals, SalA lowered fasting blood glucose (FBG and fed blood glucose in dose-dependent manner, as well as reduced 24-h food and water intake. In vitro, SalA caused dose-dependent increase in glucose consumption and enhanced glucose uptake. SalA significantly increased ATP production from 10 min to 12 h in HepG2 cells and L6 myotubes. Interestingly, SalA decreased mitochondrial membrane potential (MMP in HepG2 cells. Furthermore, SalA improved hepatic and skeletal muscle mitochondrial function, increased ATP production, and concurrently decreased MMP. In particularly, SalA activated AMPK phosphorylation through Ca2+/calmodulin-dependent protein kinase kinase β (CaMKKβ/AMPK signaling pathway, independent of liver kinase 1 (LKB1/AMPK pathway. However, SalA didn't show any effect on insulin secretagogue and activation of PI3K/Akt signaling pathway. Conclusion: SalA exhibits the antidiabetic effects in diabetic animal models through

Baltics support Kosovo independence / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2008-01-01

Balti riigid teatasid päev pärast Kosovo iseseisvuse väljakuulutamist, et toetavad riigi iseseisvust. Eriarvamusi pretsedendi suhtes on venelaste esindajate hulgas ning Euroopa riikide vahel. Baltimaade liidrite põhjendused

Zatlers takes over presidency / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2007-01-01

Läti uus president Valdis Zatlers võttis ametist lahkunud riigipealt Vaira Vike-Freibergalt ametivolitused üle. Vaira Vike-Freiberga lahkumiskõnest. Korruptsioonisüüdistused seni kirurgina töötanud Valdis Zatlersi aadressil

Mitmetasandiline hinnang: vaade 360 kraadi / Kaspar Saul

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Saul, Kaspar

2008-01-01

Ülevaade Kaspar Sauli 2008. aastal Tallinna Ülikoolis kaitstud magistritööst "Ajateenijatele antud hinnangute ja militaarsoorituse seos Eesti kaitseväes jalaväe väljaõppekeskuse Pärnu üksik-jalaväepataljon näitel", milles analüüsitakse ajateenijatele antud hinnangute seoseid nende militaarsooritusega ning hinnanguankeedi kui mõõdiku usaldusväärsust. Tabel

Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia.

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Chen, Tong; Ma, Zhanqiang; Zhu, Lingpeng; Jiang, Wenjiao; Wei, Tingting; Zhou, Rui; Luo, Fen; Zhang, Kai; Fu, Qiang; Ma, Chunhua; Yan, Tianhua

2016-11-01

The purpose of the current study was to detect the effect of salidroside (Sal) on cerebral ischemia and explore its potential mechanism. Middle cerebral artery occlusion (MCAO) was performed to investigate the effects of Sal on cerebral ischemia. The rats were randomly divided into five groups: sham group, vehicle group, clopidogrel (7.5 mg/kg) group, Sal (20 mg/kg) group, and Sal (40 mg/kg) group. SH-SY5Y cells were exposed to ischemia-reperfusion (I/R) injury to verify the protective effect of Sal in vitro. We also built the stable receptor-interacting protein 140 (RIP140)-overexpressing SH-SY5Y cells. The results showed that Sal significantly reduces brain infarct size and cerebral edema. Sal could effectively decrease the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in serum of the MCAO rats and supernatant of I/R-induced SH-SY5Y cells. Immunohistochemical and Western blot results demonstrated that Sal inhibited RIP140-mediated inflammation and apoptosis in the MCAO rats and SH-SY5Y cells. In addition, we further confirmed that RIP140/NF-κB signaling plays a crucial role by evaluating the protein expression in RIP140-overexpressing SH-SY5Y cells. Our findings suggested that Sal could be used as an effective neuroprotective agent for cerebral ischemia due to its significant effect on preventing neuronal cell injury after cerebral ischemia both in vivo and in vitro by the inhibitions of RIP140-mediated inflammation and apoptosis.

Antibacterial activity of Pd(II) complexes with salicylaldehyde-amino acids Schiff bases ligands.

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Rîmbu, Cristina; Danac, Ramona; Pui, Aurel

2014-01-01

Palladium(II) complexes with Schiff bases ligands derived from salicylaldehyde and amino acids (Ala, Gly, Met, Ser, Val) have been synthesized and characterized by Fourier transform (FT)-IR, UV-Vis and (1)H-NMR spectroscopy. The electrospray mass spectrometry (ES-MS) spectrometry confirms the formation of palladium(II) complexes in 1/2 (M/L) molar ratio. All the Pd(II) complexes 1, [Pd(SalAla)2]Cl2; 2, [Pd(SalGly)2]Cl2; 3, [Pd(SalMet)2]Cl2; 4, [Pd(SalSer)2]Cl2; 5, [Pd(SalVal)2]Cl2; have shown antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli.

Salinomycin nanoparticles interfere with tumor cell growth and the tumor microenvironment in an orthotopic model of pancreatic cancer.

Science.gov (United States)

Daman, Zahra; Faghihi, Homa; Montazeri, Hamed

2018-05-02

Recently, salinomycin (SAL) has been reported to inhibit proliferation and induce apoptosis in various tumors. The aim of this study was to deliver SAL to orthotopic model of pancreatic cancer by the aid of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). The NPs were physico-chemically characterized and evaluated for cytotoxicity on luciferase-transduced AsPC-1 cells in vitro as well as implanted orthotopically into the pancreas of nude mice. SAL (3.5 mg/kg every other day) blocked tumor growth by 52% compared to the control group after 3 weeks of therapy. Western blotting of tumor protein extracts indicated that SAL treatment leads to up-regulation of E-cadherin, β-catenin, and transforming growth factor beta receptor (TGFβR) expressions in AsPC-1 orthotopic tumor. Noteworthy, immunofluorescence staining of adjacent tumor sections showed that treatment with SAL NPs cause significant apoptosis in the tumor cells rather than the stroma. Further investigations also revealed that TGFβR2 over-expression was induced in stroma cells after treatment with SAL NPs. These results highlight SAL-loaded PLGA NPs as a promising system for pancreatic cancer treatment, while the mechanistic questions need to be subsequently tested.

15.SFPS "Ieņēmumi no līgumiem ar klientiem"un 16.SFPS "Noma" prasības un to salīdzinājums ar iepriekšējiem SFPS/SGS un LR likumdošanu

OpenAIRE

Dābola, Iveta

2016-01-01

Maģistra darba temats 15. SFPS “Ieņēmumi no līgumiem ar klientiem” un 16. SFPS “Noma” prasības un to salīdzinājums ar iepriekšējiem SFPS/SGS un LR likumdošanu. Maģistra darba mērķis - balstoties uz 15. SFPS “Ieņēmumi no līgumiem ar klientiem” un 16. SFPS “Noma” standartu prasību izpēti un analīzi, novērtēt Latvijas likumdošanas atbilstību minēto standartu prasībām un sniegt priekšlikumus konkrētu jautājumu risināšanai Latvijas kontekstā. Maģistra darbā izpētīti LR normatīvie regulējumi un sta...

The evolving genetic risk for sporadic ALS.

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Gibson, Summer B; Downie, Jonathan M; Tsetsou, Spyridoula; Feusier, Julie E; Figueroa, Karla P; Bromberg, Mark B; Jorde, Lynn B; Pulst, Stefan M

2017-07-18

To estimate the genetic risk conferred by known amyotrophic lateral sclerosis (ALS)-associated genes to the pathogenesis of sporadic ALS (SALS) using variant allele frequencies combined with predicted variant pathogenicity. Whole exome sequencing and repeat expansion PCR of C9orf72 and ATXN2 were performed on 87 patients of European ancestry with SALS seen at the University of Utah. DNA variants that change the protein coding sequence of 31 ALS-associated genes were annotated to determine which were rare and deleterious as predicted by MetaSVM. The percentage of patients with SALS with a rare and deleterious variant or repeat expansion in an ALS-associated gene was calculated. An odds ratio analysis was performed comparing the burden of ALS-associated genes in patients with SALS vs 324 normal controls. Nineteen rare nonsynonymous variants in an ALS-associated gene, 2 of which were found in 2 different individuals, were identified in 21 patients with SALS. Further, 5 deleterious C9orf72 and 2 ATXN2 repeat expansions were identified. A total of 17.2% of patients with SALS had a rare and deleterious variant or repeat expansion in an ALS-associated gene. The genetic burden of ALS-associated genes in patients with SALS as predicted by MetaSVM was significantly higher than in normal controls. Previous analyses have identified SALS-predisposing variants only in terms of their rarity in normal control populations. By incorporating variant pathogenicity as well as variant frequency, we demonstrated that the genetic risk contributed by these genes for SALS is substantially lower than previous estimates. © 2017 American Academy of Neurology.

[When Should We Perform Surgery for N2 Lung Cancer?;Induction Chemoradiotherapy or Surgery for Local Recurrence or Residual Tumor after Definitive Chemoradiotherapy].

Science.gov (United States)

Ito, Hiroyuki; Nakayama, Haruhiko

2018-04-01

Standard treatment for locally advanced clinical N2 lung cancer is definitive chemoradiotherapy, and induction chemoradiotherapy(IND-CRT) followed by surgery is an option. Most of them recurs remotely within a few years after initial therapy. Patients who received salvage surgery(SAL) after definitive chemoradiotherapy had no remote relapse for some period after definitive chemoradiotherapy, thus the outcome of SAL may be better than those of IND-CRT, but the operative risks of both procedures seem to be high. To compare the prognosis and risk of SAL and IND-CRT. From January 2001 through December 2015, 39 patients with clinical N2 primary lung cancer underwent surgery after chemoradiotherapy. Twenty-six patients received IND-CRT, and 13 underwent SAL. Perioperative factors, overall survival rates at 5 years, lung-cancer-specific mortality, relapse-free survival rates, and the rates of perioperative complications were compared between the groups. The median follow up period was 41.0 months(5~120 months). Twelve patients were women, and 27 were men. The average age was 60.2 years. The patients comprised 1.7% of the 2,330 anatomical resections performed during the same period. The radiation dose was 46.4 Gy who received IND-CRT and 61.4 Gy in those who received SAL(pperformed in 37 patients, pneumonectomy in 2 patients. In patients who received IND-CRT, an average operation time was 236 minutes, mean bleeding volume was 135 g. In patients who underwent SAL, they were 236 minutes and 188 g(p=0.998, p=0.365). There was no perioperative and in-hospital death in either group. Postoperative complications developed in 5 of INDCRT(19.2%)and 3 in SAL(23.1%). The 5-year overall survival rate of all cases was 60.4%(IND-CRT 53.9, SAL 81.8%;p=0.737). The lung cancer-specific survival rate at 5 years was 60.4% overall, 57.5% in IND-CRT, and 90.0% in SAL(p=0.176). The 5-year relapse-free survival rate was 52.7% overall, 37.6% in IND-CRT, 57.7% in SAL(p=0.175). Although the

Oxovanadium(IV)-catalysed oxidation of dibenzothiophene and 4,6-dimethyldibenzothiophene.

Science.gov (United States)

Ogunlaja, Adeniyi S; Chidawanyika, Wadzanai; Antunes, Edith; Fernandes, Manuel A; Nyokong, Tebello; Torto, Nelson; Tshentu, Zenixole R

2012-12-07

The reaction between [V(IV)OSO(4)] and the tetradentate N(2)O(2)-donor Schiff base ligand, N,N-bis(o-hydroxybenzaldehyde)phenylenediamine (sal-HBPD), obtained by the condensation of salicylaldehyde and o-phenylenediamine in a molar ratio of 2 : 1 respectively, resulted in the formation of [V(IV)O(sal-HBPD)]. The molecular structure of [V(IV)O(sal-HBPD)] was determined by single crystal X-ray diffraction, and confirmed the distorted square pyramidal geometry of the complex with the N(2)O(2) binding mode of the tetradentate ligand. The formation of the polymer-supported p[V(IV)O(sal-AHBPD)] proceeded via the nitrosation of sal-HBPD, followed by the reduction with hydrogen to form an amine group that was then linked to Merrifield beads followed by the reaction with [V(IV)OSO(4)]. XPS and EPR were used to confirm the presence of oxovanadium(IV) within the beads. The BET surface area and porosity of the heterogeneous catalyst p[V(IV)O(sal-AHBPD)] were found to be 6.9 m(2) g(-1) and 180.8 Å respectively. Microanalysis, TG, UV-Vis and FT-IR were used for further characterization of both [V(IV)O(sal-HBPD)] and p[V(IV)O(sal-AHBPD)]. Oxidation of dibenzothiophene (DBT) and 4,6-dimethyldibenzothiophene (4,6-DMDBT) was investigated using [V(IV)O(sal-HBPD)] and p[V(IV)O(sal-AHBPD)] as catalysts. Progress for oxidation of these model compounds was monitored with a gas chromatograph fitted with a flame ionization detector. The oxidation products were characterized using gas chromatography-mass spectrometry, microanalysis and NMR. Dibenzothiophene sulfone (DBTO(2)) and 4,6-dimethyldibenzothiophene sulfone (4,6-DMDBTO(2)) were found to be the main products of oxidation. Oxovanadium(IV) Schiff base microspherical beads, p[V(IV)O(sal-AHBPD)], were able to catalyse the oxidation of sulfur in dibenzothiophene (DBT) and 4,6-dimethyldibenzothiophene (4,6-DMDBT) to a tune of 88.0% and 71.8% respectively after 3 h at 40 °C. These oxidation results show promise for potential application

Potentiation activity of multiple antibacterial agents by Salvianolate from the Chinese medicine Danshen against methicillin-resistant Staphylococcus aureus (MRSA

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Qing-Qing Liu

2016-05-01

Full Text Available Salvianolate (SAL is a prescribed medicine from the Chinese herb Danshen (Salvia miltiorrhiza Bunge. It has been widely used in treatment of coronary and other diseases with significant effects. The in vitro antimicrobial activities of SAL against infectious pathogens were assayed and its combined effects on 10 clinical isolates of SCCmec III type methicillin-resistant Staphylococcus aureus (MRSA with ten antibiotics were evaluated. Susceptibility to each agent alone was tested using a broth microdilution method, and the chequerboard and time-kill experiments were used for the combined activities. The results showed MIC was 128–256 mg/L for SAL used alone against MRSA. Significant synergies were observed for SAL/Ampicillin (Fosfomycin, Erythromycin, Piperacillin-tazobactam or Clindamycin combination against over half of the isolates, with their MICs reduced by times of dilution (TOD to 4–32 (FICIs 0.375–0.5, respectively. SAL/AMP combination showed the best combined effect of synergy on bacteriostatic and bactericidal activities, while SAL/AMK combination reversed the resistance of MRSA to AMK. The results demonstrated that SAL enhanced widely the in vitro anti-MRSA efficacy of the ten antibacterial agents, which had potential for combinatory therapy of patients infected with MRSA and warrants further investigations.

Sodio y medicamentos

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Satué E.

2011-06-01

Full Text Available Leyendo el Volumen 2 número 4 de la revista, he visto la interesantísima revisión sobre la sal en analgésicos efervescentes del doctor Martínez1. Quisiera felicitar al autor, ya que incide en muchos puntos fundamentales: impacto de la sal en la hipertensión arterial (HTA, el factor sal-sensible/sal-resistente, estrategia de la Organización Mundial de la Salud (OMS acerca del consumo de sal, contenido de sodio de los distintos analgésicos efervescentes, la importancia de evitar su consumo en las personas con problemas cardiovasculares (CV, renales, etc., lo cual muestra la necesidad de que los farmacéuticos nos impliquemos en la influencia que los medicamentos con alto contenido en sodio pueden tener en nuestros pacientes.

Development of Smart Active Layer Sensor (II): Manufacturing and Application

International Nuclear Information System (INIS)

Lee, Young Sup; Lee, Sang Il; Kwon, Jae Hwa; Yoon, Dong Jin

2004-01-01

This paper is the second part of the study on the development of a smart active layer (SAL) sensor, which consists of two parts. As mentioned in the first paper, structural health monitoring (SHM) is a new technology that is being increasingly applied at the industrial field as a potential approach to improve cost and convenience of structural inspection. Recently, the development of smart sensor is very active for real application. This study has focused on preparation and application study of SAL sensor which is described with regard to the theory and concept of the SAL sensor in the first paper. In order to detect elastic wave, smart piezoelectric sensor, SAL, is fabricated by using a piezoelectric element, shielding layer and protection layer. This protection layer plays an important role in a patched network of distributed piezoelectric sensor and shielding treatment. Four types of SAL sensor are designed/prepared/tested, and these details will be discussed in the paper In this study, SAL sensor ran be feasibly applied to perform structural health monitoring and to detect damage sources which result in elastic waves

TÜRKİYE’DE DIŞ TİCARET VE KARBONDİOKSİT SALINIMI ARASINDAKİ İLİŞKİLERİN SİMETRİK VE ASİMETRİK NEDENSELLİK TESTLERİYLE ANALİZİ

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Mustafa Kemal DEĞER

2017-01-01

Full Text Available Dış ticaret, karbondioksit salınımını doğrudan ve dolaylı bir şekilde etkileyebilmektedir. Doğrudan etkinin karbondioksit salınımını arttırması, dolaylı etkinin azaltması sebebiyle artan dış ticaretin karbondioksit salınımı üzerindeki etkisi belirsizdir. Bu çalışma, Türkiye’de dış ticaret ile karbondioksit salınımı arasındaki ilişkiyi 1971-2011 döneminde simetrik (Toda-Yamamoto (1995, Hacker-Hatemi (2006 ve asimetrik (Hatemi-J (2012 nedensellik testleri ile incelemektedir. Nedensellik testleri sonuçlarına göre dış ticaretten karbondioksit salınımına doğru pozitif tek yönlü bir nedensellik ilişkisi tespit edilmiştir. Ayrıca karbondioksit salınımından dış ticarete negatif bir geri besleme etkisinin olduğu belirlenmiştir

Inhibition of Tanshinone IIA, Salvianolic Acid A and Salvianolic Acid B on Areca Nut Extract-Induced Oral Submucous Fibrosis in Vitro

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Jian-Ping Dai

2015-04-01

Full Text Available Salvia miltiorrhiza Bunge has been reported to possess excellent antifibrotic activity. In this study, we have investigated the effect and mechanism of tanshinone IIA (Tan-IIA, salvianolic acid A (Sal-A and salvianolic acid B (Sal-B, the important active compounds of Salvia miltiorrhiza Bunge, on areca nut extract (ANE-induced oral submucous fibrosis (OSF in vitro. Through human procollagen gene promoter luciferase reporter plasmid assay, hydroxyproline assay, gelatin zymography assay, qRT-PCR, ELISA and Western blot assay, the influence of these three compounds on ANE-stimulated cell viability, collagen accumulation, procollagen gene transcription, MMP-2/-9 activity, MMP-1/-13 and TIMP-1/-2 expression, cytokine secretion and the activation of PI3K/AKT, ERK/JNK/p38 MAPK and TGF-β/Smads pathways were detected. The results showed that Tan-IIA, Sal-A and Sal-B could significantly inhibit the ANE-stimulated abnormal viability and collagen accumulation of mice oral mucosal fibroblasts (MOMFs, inhibit the transcription of procollagen gene COL1A1 and COL3A1, increase MMP-2/-9 activity, decrease TIMP-1/-2 expression and inhibit the transcription and release of CTGF, TGF-β1, IL-6 and TNF-α; Tan-IIA, Sal-A and Sal-B also inhibited the ANE-induced activation of AKT and ERK MAPK pathways in MOMFs and the activation of TGF-β/Smads pathway in HaCaT cells. In conclusion, Tan-IIA, Sal-A and Sal-B possess excellent antifibrotic activity in vitro and can possibly be used to promote the rehabilitation of OSF patients.

LASE Measurements of Water Vapor, Aerosol, and Cloud Distributions in Saharan Air Layers and Tropical Disturbances

Science.gov (United States)

Ismail, Syed; Ferrare, Richard A.; Browell, Edward V.; Kooi, Susan A.; Dunion, Jason P.; Heymsfield, Gerry; Notari, Anthony; Butler, Carolyn F.; Burton, Sharon; Fenn, Marta;

Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling

Energy Technology Data Exchange (ETDEWEB)

Liu, Bin, E-mail: iamicehe@163.com [Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistic University of Chinese People' s Armed Police Force, Tianjin 300162 (China); Cao, Bo, E-mail: caobo19814@126.com [Logistics University of Chinese People' s Armed Police Force, Tianjin 300162 (China); Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Tianjin, 300162 (China); Zhang, Di, E-mail: zhangdibad@163.com [Department of Otorhinolaryngology Head and Neck Surgery, Institute of Otorhinolaryngology, Tianjin First Center Hospital, Tianjin 300192 (China); Xiao, Na [Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistic University of Chinese People' s Armed Police Force, Tianjin 300162 (China); Chen, Hong [Logistics University of Chinese People' s Armed Police Force, Tianjin 300162 (China); Li, Guo-qiang; Peng, Shou-chun [Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistic University of Chinese People' s Armed Police Force, Tianjin 300162 (China); Wei, Lu-qing, E-mail: luqing-wei@163.com [Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistic University of Chinese People' s Armed Police Force, Tianjin 300162 (China)

2016-10-15

The present study was aimed at exploring the protective effects of Salvianolic acid B (SalB) against paraquat (PQ)-induced lung injury in mice. Lung fibrotic injuries were induced in mice by a single intragastrical administration of 300 mg/kg PQ, then the mice were administrated with 200 mg/kg, 400 mg/kg SalB, 100 mg/kg vitamin C (Vit C) and dexamethasone (DXM) for 14 days. PQ-triggered structure distortion, collagen overproduction, excessive inflammatory infiltration, pro-inflammatory cytokine release, and oxidative stress damages in lung tissues and mortality of mice were attenuated by SalB in a dose-dependent manner. Furthermore, SalB was noted to enhance the expression and nuclear translocation of nuclear factor erythroid 2–related factor 2 (Nrf2) and reduce expression of the reactive oxygen species-generating enzyme Nox4 [NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-4]. SalB also inhibited the increasing expression of transforming growth factor (TGF)-β1 and the phosphorylation of its downstream target Smad3 which were enhanced by PQ. These results suggest that SalB may exert protective effects against PQ-induced lung injury and pulmonary fibrosis. Its mechanisms involve the mediation of Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling. - Highlights: • Salvianolic acid B (SalB) reduced Paraquat-induced mortality and pulmonary injury in mice. • SalB has anti-oxidation, anti-inflammatory and anti-fibrogenic effects simultaneously. • Its mechanisms were targeting Nrf2-Nox4 redox balance and TGF-β1/Smad3 signaling.

Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling

International Nuclear Information System (INIS)

Liu, Bin; Cao, Bo; Zhang, Di; Xiao, Na; Chen, Hong; Li, Guo-qiang; Peng, Shou-chun; Wei, Lu-qing

2016-01-01

The present study was aimed at exploring the protective effects of Salvianolic acid B (SalB) against paraquat (PQ)-induced lung injury in mice. Lung fibrotic injuries were induced in mice by a single intragastrical administration of 300 mg/kg PQ, then the mice were administrated with 200 mg/kg, 400 mg/kg SalB, 100 mg/kg vitamin C (Vit C) and dexamethasone (DXM) for 14 days. PQ-triggered structure distortion, collagen overproduction, excessive inflammatory infiltration, pro-inflammatory cytokine release, and oxidative stress damages in lung tissues and mortality of mice were attenuated by SalB in a dose-dependent manner. Furthermore, SalB was noted to enhance the expression and nuclear translocation of nuclear factor erythroid 2–related factor 2 (Nrf2) and reduce expression of the reactive oxygen species-generating enzyme Nox4 [NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-4]. SalB also inhibited the increasing expression of transforming growth factor (TGF)-β1 and the phosphorylation of its downstream target Smad3 which were enhanced by PQ. These results suggest that SalB may exert protective effects against PQ-induced lung injury and pulmonary fibrosis. Its mechanisms involve the mediation of Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling. - Highlights: • Salvianolic acid B (SalB) reduced Paraquat-induced mortality and pulmonary injury in mice. • SalB has anti-oxidation, anti-inflammatory and anti-fibrogenic effects simultaneously. • Its mechanisms were targeting Nrf2-Nox4 redox balance and TGF-β1/Smad3 signaling.

Transnational Militancy in the 21st Century (roundtable discussion

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Faisal Devji

2010-01-01

Full Text Available The following roundtable discussion took place via email between September 2009 and January 2010. The participants were invited on the basis of each having a unique disciplinary background – history, sociology and political theory – but at the same time enough in common to debate both the analytic and normative dimensions of transnational militancy. Faisal Devji is currently Reader in Modern South Asian History at St. Antony’s College, University of Oxford. His most recent book is The Terrorist in Search of Humanity: Militant Islam and GlobalPolitics. Prof. Kevin McDonald is Marie Curie International Fellow in the Department of Sociology at Goldsmiths College, University of London. His most recent book, Our Violent World: Terrorism in Society, is being published April, 2010. Saul Newman is Reader in Political Theory, also at Goldsmiths College. Saul is known for his work on ‘postanarchist’ theory, but also recently co-authored a book with the title Politics Most Unusual: Violence, Sovereignty and Democracy in the War on Terror. The roundtable was initiated and chaired by Journal of Critical Globalisation Studies co-editor Nathan Coombs.

Contexto e intertextualidad en los títulos de crédito de Watchmen. Context and intertextuality in Watchmen's opening credits

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Raúl Polo Montilla

2012-04-01

Full Text Available Los títulos de crédito de numerosos films se han conformado como algo más que una lista de nombres. Autores como Saul Bass o Kyle Cooper han convertido las secuencias iniciales de los films en microhistorias que avanzan o sintetizan el tono o la atmósfera del film, erigiéndose como el prólogo de la narración. El siguiente artículo analiza en profundidad la secuencia inicial de créditos de Watchmen (Zack Snyder, 2009, cuya función sintetizadora es vital para entender el contexto de una atípica película de superhéroes.Credits of many films has been formed like something more of a name's list. Authors like Saul Bass or Kyle Cooper have turned film's opening sequences into microhistories that gives us an idea or summarizes the tone and film's atmosphere, becoming a prelude of the story. This article executes a deep analysis of the opening credits of Watchmen (Zack Snyder, 2009, whose summarizes function is vital to understand the context of an inusual superhero's movie

Comparison of cardioprotective effects using salvianolic acid B and benazepril for the treatment of chronic myocardial infarction in rats.

Science.gov (United States)

He, Haibo; Shi, Mengqiong; Yang, Xianzhe; Zeng, Xiaowei; Wu, Limao; Li, Lianda

2008-09-01

The aim of this study was to compare the cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with chronic myocardial infarction (MI) that resulted from a coronary artery ligation for 4 weeks. The rats were divided into four groups: those undergoing a sham operation; a MI group; a MI+SalB group (100 mg/kg by a gavage, once a day for 4 weeks); a MI+benazepril group (10 mg/kg by a gavage, once a day for 4 weeks). The following parameters were measured: echocardiographic, hemodynamic and hemorheological changes, angiogenesis, infarct size and cardiac remodeling and the messenger ribonucleic acid (mRNA) of vascular endothelium growth factor (VEGF). Rats treated with SalB or benazepril manifested the following: (1) marked improvements in echocardiographic, hemodynamic and hemorheological parameters; (2) significant reduction of infarct size; (3) significantly attenuated heart, kidney and lung hypertrophies, left ventricular (LV) dilatation and fibrosis. The unique effects of SalB were angiogenesis and augmented VEGF expression in the border and remote noninfarcted left ventricular area. These results suggest that both SalB and benazepril exerted beneficial cardioprotective effects in our experimental system, but that the modality of Sal B was different from that of benazepril. The additional beneficial effects of Sal B relative to benazpril, augmenting VEGF expression and promoting angiogenesis, may result in improved myocardial microcirculation.

Potentiation activity of multiple antibacterial agents by Salvianolate from the Chinese medicine Danshen against methicillin-resistant Staphylococcus aureus (MRSA).

Science.gov (United States)

Liu, Qing-Qing; Han, Jun; Zuo, Guo-Ying; Wang, Gen-Chun; Tang, Hua-Shu

2016-05-01

Salvianolate (SAL) is a prescribed medicine from the Chinese herb Danshen (Salvia miltiorrhiza Bunge). It has been widely used in treatment of coronary and other diseases with significant effects. The in vitro antimicrobial activities of SAL against infectious pathogens were assayed and its combined effects on 10 clinical isolates of SCCmec III type methicillin-resistant Staphylococcus aureus (MRSA) with ten antibiotics were evaluated. Susceptibility to each agent alone was tested using a broth microdilution method, and the chequerboard and time-kill experiments were used for the combined activities. The results showed MIC was 128-256 mg/L for SAL used alone against MRSA. Significant synergies were observed for SAL/Ampicillin (Fosfomycin, Erythromycin, Piperacillin-tazobactam or Clindamycin) combination against over half of the isolates, with their MICs reduced by times of dilution (TOD) to 4-32 (FICIs 0.375-0.5), respectively. SAL/AMP combination showed the best combined effect of synergy on bacteriostatic and bactericidal activities, while SAL/AMK combination reversed the resistance of MRSA to AMK. The results demonstrated that SAL enhanced widely the in vitro anti-MRSA efficacy of the ten antibacterial agents, which had potential for combinatory therapy of patients infected with MRSA and warrants further investigations. Copyright © 2015 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Determination of trace uranium by resonance fluorescence method coupled with photo-catalytic technology and dual cloud point extraction.

Science.gov (United States)

Li, Jiekang; Li, Guirong; Han, Qian

2016-12-05

In this paper, two kinds of salophens (Sal) with different solubilities, Sal1 and Sal2, have been respectively synthesized, and they all can combine with uranyl to form stable complexes: [UO2(2+)-Sal1] and [UO2(2+)-Sal2]. Among them, [UO2(2+)-Sal1] was used as ligand to extract uranium in complex samples by dual cloud point extraction (dCPE), and [UO2(2+)-Sal2] was used as catalyst for the determination of uranium by photocatalytic resonance fluorescence (RF) method. The photocatalytic characteristic of [UO2(2+)-Sal2] on the oxidized pyronine Y (PRY) by potassium bromate which leads to the decrease of RF intensity of PRY were studied. The reduced value of RF intensity of reaction system (ΔF) is in proportional to the concentration of uranium (c), and a novel photo-catalytic RF method was developed for the determination of trace uranium (VI) after dCPE. The combination of photo-catalytic RF techniques and dCPE procedure endows the presented methods with enhanced sensitivity and selectivity. Under optimal conditions, the linear calibration curves range for 0.067 to 6.57ngmL(-1), the linear regression equation was ΔF=438.0 c (ngmL(-1))+175.6 with the correlation coefficient r=0.9981. The limit of detection was 0.066ngmL(-1). The proposed method was successfully applied for the separation and determination of uranium in real samples with the recoveries of 95.0-103.5%. The mechanisms of the indicator reaction and dCPE are discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning.

Science.gov (United States)

Baldridge, Sarah L; Coetzee, Johann F; Dritz, Steve S; Reinbold, James B; Gehring, Ronette; Havel, James; Kukanich, Butch

2011-10-01

To determine the pharmacokinetic parameters of xylazine, ketamine, and butorphanol (XKB) administered IM and sodium salicylate (SAL) administered PO to calves and to compare drug effects on biomarkers of pain and distress following sham and actual castration and dehorning. 40 Holstein bull calves from 3 farms. Calves weighing 108 to 235 kg (n = 10 calves/group) received one of the following treatments prior to sham (period 1) and actual (period 2) castration and dehorning: saline (0.9% NaCl) solution IM (placebo); SAL administered PO through drinking water at concentrations from 2.5 to 5 mg/mL from 24 hours prior to period 1 to 48 hours after period 2; butorphanol (0.025 mg/kg), xylazine (0.05 mg/kg), and ketamine (0.1 mg/kg) coadministered IM immediately prior to both periods; and a combination of SAL and XKB (SAL+XKB). Plasma drug concentrations, average daily gain (ADG), chute exit velocity, serum cortisol concentrations, and electrodermal activity were evaluated. ADG (days 0 to 13) was significantly greater in the SAL and SAL+XKB groups than in the other 2 groups. Calves receiving XKB had reduced chute exit velocity in both periods. Serum cortisol concentrations increased in all groups from period 1 to period 2. However, XKB attenuated the cortisol response for the first hour after castration and dehorning and oral SAL administration reduced the response from 1 to 6 hours. Administration of XKB decreased electrodermal activity scores in both periods. SAL administered PO through drinking water decreased cortisol concentrations and reduced the decrease in ADG associated with castration and dehorning in calves.

Lugejate valik : Peep Vain on parim / Marko Liibak

Index Scriptorium Estoniae

Liibak, Marko

2007-01-01

Aripaev.ee ja ajaleht Äripäev korraldasid lugejate seas küsitluse, mille käigus valiti Eesti parimaks koolitajaks Vain & Partnerite omanik ning koolituskonsultant Peep Vain. Teisele kohale tuli koolitaja, juhtimiskonsultant ja nõustaja ning Tallinn Ülikooli kliinilise psühholoogia professor Mare Pork. Järgnesid Ülo Vihma, Indrek Saul, Tiit Valm, Mihkel Pärjamäe ning Alexander Kotchubei

TACOM Leadership Skills for the 21st Century (An Employee Perspective)

Science.gov (United States)

2012-04-01

successful. Robert Thorndike and Saul Stein were writing about this theory in 1937. In their journal article they describe the concept of “social...intelligence” as the ability to get along with other people. ( Thorndike & Stein, 1937) These original views on intelligence continue to be validated...Birmingham: Learning Center Incorporated. Thorndike , R., & Stein, S. (1937). An Evaluation of the Attempts to Measure Social Intelligence

Quality management at the Safeguards Analytical Laboratory of IAEA

International Nuclear Information System (INIS)

Aigner, H.; Doherty, P.; Donohue, D.; Kuno, Y.

2001-01-01

Full text: In the year 2000, SAL'S quality management system was certified for conforming with the requirements of the international standard ISO-9002: 1994. The certification incurred considerable efforts, both in manpower and capital investments. The expected benefits of a formal quality management system do not directly target the correctness and reliability of analytical results. SAL believes that it was already performing well in this respect, even before re-shaping its quality system according to the reference model. Systematic QA and QC procedures have been applied since the begin of SAL'S operations in the mid-70's. The management framework specified in ISO-9002: 1994 complements these technical measures. Besides its value of being internationally recognised and thus enhancing perhaps the credibility in the quality of SAL'S services, the quality management system in this form provides additional advantages for the customer of the services of SAL, i.e. the Department of Safeguards of the IAEA, but also for the control and management of SAL'S internal 'business' processes. The paper discusses if these expected additional benefits are indeed obtained and whether or not their value is in balance with operational and initial investment costs. (author)

Insertion of a specific fungal 3'-phosphoadenosine-5'-phosphatase motif into a plant homologue improves halotolerance and drought tolerance of plants.

Science.gov (United States)

Gašparič, Meti Buh; Lenassi, Metka; Gostinčar, Cene; Rotter, Ana; Plemenitaš, Ana; Gunde-Cimerman, Nina; Gruden, Kristina; Zel, Jana

2013-01-01

Soil salinity and drought are among the most serious agricultural and environmental problems of today. Therefore, investigations of plant resistance to abiotic stress have received a lot of attention in recent years. In this study, we identified the complete coding sequence of a 3'-phosphoadenosine-5'-phosphatase protein, ApHal2, from the halotolerant yeast Aureobasidium pullulans. Expression of the ApHAL2 gene in a Saccharomyces cerevisiae hal2 mutant complemented the mutant auxotrophy for methionine, and rescued the growth of the hal2 mutant in media with high NaCl concentrations. A 21-amino-acids-long region of the ApHal2 enzyme was inserted into the Arabidopsis thaliana homologue of Hal2, the SAL1 phosphatase. The inserted sequence included the META motif, which has previously been implicated in increased sodium tolerance of the Hal2 homologue from a related fungal species. Transgenic Arabidopsis plants overexpressing this modified SAL1 (mSAL1) showed improved halotolerance and drought tolerance. In a medium with an elevated salt concentration, mSAL1-expressing plants were twice as likely to have roots in a higher length category in comparison with the wild-type Arabidopsis and with plants overexpressing the native SAL1, and had 5% to 10% larger leaf surface area under moderate and severe salt stress, respectively. Similarly, after moderate drought exposure, the mSAL1-expressing plants showed 14% increased dry weight after revitalisation, with no increase in dry weight of the wild-type plants. With severe drought, plants overexpressing native SAL1 had the worst rehydration success, consistent with the recently proposed role of SAL1 in severe drought. This was not observed for plants expressing mSAL1. Therefore, the presence of this fungal META motif sequence is beneficial under conditions of increased salinity and moderate drought, and shows no drawbacks for plant survival under severe drought. This demonstrates that adaptations of extremotolerant fungi should

Protection by free oxygen radical scavenging enzymes against salicylate-induced embryonic malformations in vitro.

Science.gov (United States)

Karabulut, A K; Ulger, H; Pratten, M K

2000-08-01

Salicylates are among the oldest and most widely used drugs and are known to lead to foetal death, growth retardation and congenital abnormalities in experimental animals. In this study, the effects of acetyl salicylic acid (ASA), salicylic acid (SAL) and sodium salicylate (NaSAL) on early organogenesis and the interaction of these molecules with free radicals has been investigated. Postimplantation rat embryos were cultured in vitro from day 9.5 of gestation for 48 hr. ASA, SAL and NaSAL were added to whole rat serum at concentrations between 0.1 and 0.6 mg/ml. Also, the lowest effective concentration of ASA for all parameters (0.3 mg/ml) and the same concentration of NaSAL and SAL was added to the culture media in the presence of superoxide dismutase (SOD) (30 U/ml) or glutathione (0.5 micromol/ml). The growth and development of embryos was compared and each embryo was evaluated for the presence of any malformations. When compared to growth of control embryos, the salicylates decreased all growth and developmental parameters in a concentration-responsive manner. There was also a concentration-related increase in overall dysmorphology, including the incidence of haematoma in the yolk sac and neural system, open neural tube, abnormal tail torsion and the absence of fore limb bud. When SOD was added in the presence of ASA, growth and developmental parameters were improved and there was a significant decrease in the incidence of malformations. Addition of SOD also decreased the incidence of malformations in the presence of SAL, but did not effect the growth and developmental parameters of SAL and NaSAL. There was no significant difference between the embryos grown in the presence of these three molecules on the addition of glutathione. The effects of salicylates might involve free oxygen radicals by the non-enzymatic production of the highly teratogenic metabolites 2,3- and 2,5-dihydroxybenzoic acid. An enhanced production of these metabolites in embryonic tissues

Influence of Salmonella status on the long-term outcome of horses after colic surgery.

Science.gov (United States)

Southwood, Louise L; Lindborg, Susan; Myers, Marc; Aceto, Helen W

2017-08-01

To compare long-term outcome of Salmonella-positive versus Salmonella-negative horses discharged from hospital after colic surgery. Retrospective case-control. Horses discharged from the hospital after colic surgery. For each horse with positive culture for Salmonella enterica (SAL-POS, n = 59), at least 2 horses testing negative for S. enterica (SAL-NEG, n = 119) were enrolled. Owners were interviewed via phone at least 12 months after surgery regarding: (1) complications after discharge from the hospital; (2) duration of survival; and (3) return to prior or intended use. Association between immediate postoperative clinical variables such as Salmonella status and long-term measures of outcome was tested via ratios (odds ratio [OR]) and 95% confidence intervals. Data were analyzed for survival using a Cox proportional hazards model and for return to use using multivariable logistic regression. SAL-POS horses had a higher OR of surgical site infection (2.7 [1.1-6.9] P = .027) and weight loss (6.8 [1.8-26.1] P = .002). At the time of follow-up, there were 53/56 (95%) SAL-POS and 99/118 (84%) SAL-NEG horses alive. The final multivariable model for nonsurvival included postoperative colic (hazard ratio 7.6 [2.8-19.2] P = .002) and the interaction between Salmonella status and duration of rectal temperature > 103°F postoperatively (SAL-POS 1.04 [1.01-1.07] and SAL-NEG 1.16 [1.06-1.25], P = .005). The majority of horses returned to their intended use regardless of their SAL-POS (38/50, 76%) or SAL-NEG (77/96, 80%, P = .498) status. Salmonella-positive horses that survive to discharge from the hospital after colic surgery have similar risks of long-term complications (colic/diarrhea), survival, and return to function than Salmonella-negative horses. © 2017 The American College of Veterinary Surgeons.

A promissora província petrolífera do pré-sal The promising oil province of the pre-salt

Directory of Open Access Journals (Sweden)

Alessandra Aloise de Seabra

2011-06-01

Full Text Available O desafio nacional a partir da descoberta da promissora provincia petrolífera do pré-sal é estabelecer parâmetros que norteiem um desenvolvimento sustentável, com respeito ao meio ambiente e às populações locais. Em geral, os problemas dos países abundantes em petróleo decorrem da dificuldade no gerenciamento das rendas da produção. Nesse contexto, o presente artigo considera a aplicação dos royalties na zona costeira do país necessária e legítima. A partir de uma metodologia argumentativa, analisou-se a concentração da atividade petrolífera na costa, a natureza jurídica dos royalties, bem como a estrutura legislativa da divisão do recurso, a fim de contribuir com o debate sobre o rearranjo institucional dessa matéria. Conclui-se que a divisão igualitária dos recursos petrolíferos só é legítima após a retirada da parcela referente à mitigação dos impactos. Antes disso, tal divisão violaria os Princípios da Igualdade e do Poluidor-Pagador.The national challenge since the discovery of the promising oil province of the pre-salt is to establish parameters to guide sustainable development, with respect to the environment and local populations. In general, the problems of oil-abundant countries arise from the difficulty in managing incomes from the oil production. In this context, this study considers the application of royalties in the brazilian coastal zone necessary and legitimate. Through an argumentative approach, the concentration of oil activity on the coast, the legal nature of royalties, and the legislative framework regarding the division of the resource were analyzed in order to contribute to the debate about the institutional rearrangement of the matter. It could be concluded that the equal division of oil resources is legitimate only after removal of the portion relating to mitigation of impacts. Otherwise, such partition would violate the principles of equality and polluter payer.

Sensitization of Cancer Cells through Reduction of Total Akt and Downregulation of Salinomycin-Induced pAkt, pGSk3β, pTSC2, and p4EBP1 by Cotreatment with MK-2206

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Ae-Ran Choi

2014-01-01

Full Text Available MK-2206 is an inhibitor of Akt activation. It has been investigated as an anticancer drug in clinical trials assessing the potential of pAkt targeting therapy. The purpose of this study was to identify conditions that increase the sensitivity of cancer cells to MK-2206. We found that the treatment of cancer cells with a high concentration of salinomycin (Sal reduced total Akt protein levels but increased activated Akt levels. When cancer cells were cotreated with MK-2206 and Sal, both pAkt and total Akt levels were reduced. Using microscopic observation, an assessment of cleaved PARP, FACS analysis of pre-G1 region, and Hoechst staining, we found that Sal increased apoptosis of MK-2206-treated cancer cells. These results suggest that cotreatment with MK-2206 and Sal sensitizes cancer cells via reduction of both pAkt and total Akt. Furthermore, cotreatment of cancer cells with Sal and MK-2206 reduced pp70S6K, pmTOR, and pPDK1 levels. In addition, Sal-induced activation of GSK3β, TSC2, and 4EBP1 was abolished by MK-2206 cotreatment. These results suggest that cotreatment using MK-2206 and Sal could be used as a therapeutic method to sensitize cancer cells through targeting of the PI3K/Akt/mTOR pathway. Our findings may contribute to the development of MK-2206-based sensitization therapies for cancer patients.

Efficacy and safety of ipratropium bromide/salbutamol sulphate administered in a hydrofluoroalkane metered-dose inhaler for the treatment of COPD

Directory of Open Access Journals (Sweden)

Bhattacharya A

2016-06-01

Full Text Available Amal Bhattacharya,1 Salil Bhargava,2 Virendra Singh,3 Deepak Talwar,4 Jagdeep Whig,5 Juliet Rebello,6 Shrinivas Purandare,6 Jaideep Gogtay6 1Department of Medicine, MP Shah Medical College, Jamnager, Gujarat, 2Tuberculosis and Chest Diseases, MGM Medical College, Indore, Madhya Pradesh, 3Pulmonary Division, SMS Hospital, Jaipur, Rajasthan, 4Respiratory Diseases, Metro Hospital and Heart Institute, Noida, Uttar Pradesh, 5Department of Medicine, Dayanand Medical College & Hospital, Ludhiana, Punjab, 6Clinical Research Department, Cipla Ltd, Mumbai, Maharashtra, India Background: The use of chlorofluorocarbons (CFCs has contributed to the depletion of the stratospheric ozone layer resulting in serious health concerns. Ipratropium bromide/salbutamol sulphate CFC-pressurized metered-dose inhalers (IB/SAL-CFC pMDI have been in widespread use for many years without any apparent ill consequences. This combination has now been reformulated using the hydrofluoroalkane (HFA propellant. This study sought to establish the clinical noninferiority of a new HFA-containing IB/SAL pMDI to the conventional IB/SAL-CFC pMDI in subjects with mild/moderate COPD.Methods: This was a randomized, double-blind, parallel-group, multicenter study in two consecutive periods: a 14-day run-in period followed by a 85-day treatment period. Eligible mild-to-moderate stable COPD subjects aged 40-75 years were enrolled into the study and entered the run-in period during which subjects withdrew all the bronchodilators, except for salbutamol as rescue medication. Subjects were randomized to 85 days treatment with either IB/SAL-HFA or IB/SAL-CFC, 20 µg qid.Results: Of the 290 randomized patients, 249 completed the study. The primary efficacy variable was the change in forced expiratory volume in one second from predose to 60 minutes after dosing on day 85. At the end of the treatment period, the adjusted mean change in forced expiratory volume in one second at 60 minutes was 123�

Development of Smart Active Layer Sensor (I) : Theory and Concept Study

International Nuclear Information System (INIS)

Yoon, Dong Jin; Lee, Young Sup; Kwon, Jae Hwa; Lee, Sang Il

2004-01-01

This paper is the first part of the study on the development of a smart active layer (SAL) sensor, which consists of two parts. In this first part, the theory and concept of the SAL sensor is investigated, which is designed for the detection of elastic waves caused by internal cracks and damages in structures. For the development SAL sensor, (i) the basic theory of elastic waves was studied, (ii) the feasible study of the SAL as an elastic waves detection sensor using the finite element analysis (FEA) with respect to a piezoceramic disc was performed. (iii) the comparison of performances between some piezoceramic sensors and a commercial acoustic emission (AE) sensor was accomplished to ensure the applicability by the experimental means, such as a pencil lead break test. Also, the conceptional study for the SAL sensor, which can be utilized for the effective detection and locating of defects by the arrangement of regularly distributed sensors, was discussed

The association between perceived emotional support, maternal mood, salivary cortisol, salivary cortisone, and the ratio between the two compounds in response to acute stress in second trimester pregnant women.

Science.gov (United States)

La Marca-Ghaemmaghami, Pearl; La Marca, Roberto; Dainese, Sara M; Haller, Marina; Zimmermann, Roland; Ehlert, Ulrike

2013-10-01

Little is known about the effect of social support on the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis during pregnancy. Moreover, when investigating the HPA axis most studies do not consider the activity of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), an enzyme within the salivary glands that inactivates cortisol to cortisone. This study explores the association between perceived emotional support and the maternal psychobiological stress response to a standardized naturalistic stressor by assessing maternal mood and the reactivity of salivary cortisol (SalF), salivary cortisone (SalE), and the SalE/(E+F) ratio as a marker of 11β-HSD2 activity. Repeated saliva samples and measures of maternal mood were obtained from 34 healthy second trimester pregnant women undergoing amniocentesis which served as a psychological stressor. The pregnant women additionally responded to a questionnaire of perceived emotional support and provided sociodemographic (e.g., maternal educational degree) and pregnancy-specific data (e.g., planned versus unplanned pregnancy). Perceived emotional support neither showed a significant effect on mood nor on the SalF or SalE response to stress. However, a moderately strong positive association was found between perceived emotional support and SalE/(E+F) (r=.49). Additionally, the final regression analysis revealed a significant negative relationship between educational degree, planned/unplanned pregnancy and SalE/(E+F). Findings suggest a higher metabolization of cortisol to cortisone in pregnant women with higher emotional support. In contrast, higher maternal education and unplanned pregnancy appear to be associated with decreased salivary 11β-HSD2 activity. The current study emphasizes the importance of taking the activity of 11β-HSD2 into account when examining SalF. © 2013.

Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice.

Science.gov (United States)

Ling, Wei Chih; Liu, Jian; Lau, Chi Wai; Murugan, Dharmani Devi; Mustafa, Mohd Rais; Huang, Yu

2017-07-15

Salvianolic acid B (Sal B) is one of the most abundant phenolic acids derived from the root of Danshen with potent anti-oxidative properties. The present study examined the vasoprotective effect of Sal B in hypertensive mice induced by angiotensin II (Ang II). Sal B (25mg/kg/day) was administered via oral gavage for 11days to Ang II (1.2mg/kg/day)-infused C57BL/6J mice (8-10weeks old). The vascular reactivity (both endothelium-dependent relaxations and contractions) in mouse arteries was examined by wire myography. The production of reactive oxygen species (ROS), protein level and localization of angiotensin AT 1 receptors and the proteins involved in ROS formation were evaluated using dihydroethidium (DHE) fluorescence, lucigenin-enhanced chemiluminescence, immunohistochemistry and Western blotting, respectively. The changes of ROS generating proteins were also assessed in vitro in human umbilical vein endothelial cells (HUVECs) exposed to Ang II with and without co-treatment with Sal B (0.1-10nM). Oral administration of Sal B reversed the Ang II-induced elevation of arterial systolic blood pressure in mice, augmented the impaired endothelium-dependent relaxations and attenuated the exaggerated endothelium-dependent contractions in both aortas and renal arteries of Ang II-infused mice. In addition, Sal B treatment normalized the elevated levels of AT 1 receptors, NADPH oxidase subunits (NOx-2 and NOx-4) and nitrotyrosine in arteries of Ang II-infused mice or in Ang II-treated HUVECs. In summary, the present study provided additional evidence demonstrating that Sal B treatment for 11days reverses the impaired endothelial function and with a marked inhibition of AT 1 receptor-dependent vascular oxidative stress. This vasoprotective and anti-oxidative action of Sal B most likely contributes to the anti-hypertensive action of the plant-derived compound. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of an Ionophore Coccidiostat (Monensin or Salinomycin, Sodium or Potassium Bicarbonate, or Both, and Bacitracin Methylene Disalicylate in Broiler Chicken Diets

Directory of Open Access Journals (Sweden)

Hooge DM

2000-01-01

Full Text Available Peterson x Arbor Acres chicks were grown on used litter to 45 or 46 days of age in three pen trials. Coccidial inoculations were given by water at 14 days of age. Sodium bicarbonate (SBC; 0.20% or potassium bicarbonate (PBC; 0.14% was added to broiler chicken diets containing monensin (MON; 110 mg/kg or salinomycin (SAL; 66 mg/kg in Experiment 1. In Experiment 2, using SAL (55 mg/kg, three dietary bicarbonate treatments (SBC, 0.20%; PBC, 0.20%; or SBC + PBC 0.10% each were tested with or without BMD R (55 mg/kg. Diets differing in SAL, BMD R, and SBC levels were evaluated in Experiment 3. Beneficial interaction was found between ionophores and bicarbonates for mortality (lower when SBC or PBC and MON in Experiment 1. For main effects, in Experiment 1 PBC with MON or SAL improved body weight, feed conversion ratio and mortality. SAL improved weight, feed conversion ratio and mortality compared to MON. In Experiment 2, PBC with SAL improved weight, coccidial lesion score, feed conversion ratio and mortality across two levels of BMD R. The PBC and SBC were equally effective in Experiment 1, but PBC was about 0 to 40% as effective as SBC, depending on parameter in Experiment 2. Half levels of SBC plus PBC generally gave intermediate results between control and SBC. SBC with MON or SAL lowered mortalities, coccidial lesion scores, and feed conversion ratios (Experiments 1 and 2, and increased body weight (Experiment 2. In Experiment 3, BMD R in all feeds improved body weight and feed conversion versus in starter feed only, and SBC with SAL and BMD R improved all performance parameters.

President attacks Seglins on comments / Talis Saule Archdeacon

Index Scriptorium Estoniae

Archdeacon, Talis Saule

2008-01-01

Läti president kritiseeris Läti siseministrit Mareks Seglinsit, kui viimane kasutas inglaste iseloomustamiseks ebatsensuurset väljendit, saades teada, et Läti Vabadussamba rüvetajateks olid briti kodanikud

Alleged assassin "jumped of bridge" / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2007-01-01

Uued asjaolud ei lisa selgust julgeolekuteenistuse töötaja Edgars Gulbise sattumisse Daugava jõkke 26. septembril uurimisvanglasse konvoeerimise ajal. Kahtlustatakse, et politsei kasutas tema suhtes vägivalda

Young PM candidate harsh criticism / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2007-01-01

Läti Rahvaerakonna peaministrikandidaati Edgars Zalansit süüdistatakse kogemuste puudumises. Edgars Zalans ei kavatse osaleda tuntud teleajakirjaniku Janis Dombursi saates "Mis toimub Lätis?". Teised kandidaadid peaministri kohale

Gulbis investigation reveals fake CV / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2007-01-01

Endise julgestustöötaja Edgars Gulbise suhtes on alustatud mitu kriminaalprotsessi: tollitöötaja auto süütamise, kelmuse, võltsitud haridust tõendava dokumendi kasutamise ning teadliku valevandumise eest. President Zatlers kritiseeris julgestusteenistust ning põhiseaduse kaitse bürood

Presidents forgive Polish no-show / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2007-01-01

30. oktoobril 2007 Riias kohtunud Läti president Valdis Zatlers, Leedu president Valdas Adamkus ja Eesti president Toomas Hendrik Ilves olid optimistlikud kolme riigi ja Poola koostöö osas tuumaelektrijaama projektis

Competition and corporate governance in transition / Saul Estrin

Index Scriptorium Estoniae

Estrin, Saul

2002-01-01

Üleminekumajanduse analüüs: institutsionaalsete muutuste mõju ettevõtluse arengule (algtingimused; erastamise viisid; institutsionaalne ja seadusandlik võrgustik; erasektori ja riigi vahekord; tootmise konkurentsivõime). Tabelid

Parliament divided over border treaty / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2007-01-01

Läti seim võttis kümme tundi kestnud debattide järel esimesel lugemisel vastu seaduse, mis volitab valitsust allkirjastama piirilepingut Venemaaga, selgitavat deklaratsiooni lisamata. Poliitikute erinevatest vaadetest piirilepingu suhtes

Susceptibilidade da mucosa gástrica à ação lesiva de um sal biliar em ratos chagásicos crônicos

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Luiz Ernesto de Almeida Troncon

1987-12-01

Full Text Available Ratos inoculados previamente com a cepa Y do Trypanosoma cruzi (n = 15 e ratos-controles de mesma idade e sexo (n = 15 foram submetidos a estudo que consistiu no exame da mucosa gástrica após a exposição in vivo da mesma à solução acidificada de um sal biliar, o taurocolato de sódio (TC. Em 10 animais de cada grupo procedeu-se também à contagem dos neurônios do plexo mientérico do estômago e ao exame histopatológico dos corpos neuronais, feito em microscopia óptica convencional. Escores indicativos da gravidade das lesões produzidas pelo TC foram significativamente maiores (P < 0,002 nos ratos chagásicos que nos controles. A área erosada da mucosa gástrica, em % da área total da região glandular do estômago, foi significativamente maior (P0,10 entre os ratos chagásicos (1683,6 ± 449,7 n = 10 e os controles (1732,8 ± 401,1 n = 10. Não houve diferença qualitativa ao exame histopatológico dos corpos neuronais. Estes resultados indicam que, na doença de Chagas experimental crônica, a mucosa gástrica é mais sensível à ação lesiva do TC, o que sugere redução da citoproteção natural do estômago. Esta anormalidade não deve decorrer de alterações da inervação intrínseca que impliquem redução do número de neurônios intramurais do estômago, mas pode ser o resultado de alterações qualitativas não detectáveis à microscopia óptica.

Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats.

Science.gov (United States)

He, Hai-Bo; Yang, Xian-Zhe; Shi, Meng-Qiong; Zeng, Xiao-Wei; Wu, Li-Mao; Li, Lian-Da

2008-01-01

In the present study, we compared cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with large myocardial infarction (MI). The large MI was produced by coronary artery ligation for 4 weeks in rats. The rats were divided into the following groups: sham operation; MI; MI + Sal B (100 mg/kg by a gavage, once a day for 4 weeks) and MI + benazepril (1 mg/kg by a gavage, once a day for 4 weeks). Echocardiogram, hemodynamic and hemorheological changes, angiogenesis, infarct size and cardiac remodeling, as well as messenger ribonucleic acid (mRNA) of vascular endothelium growth factor (VEGF) were measured. The following similar effects were observed in MI rats treated with Sal B and benazepril: (1) a marked improvement of echocardiographic, hemodynamic and hemorheological parameters, (2) significant reduction of infarct size, (3) significantly attenuated heart hypertrophy, left ventricular (LV) dilatation and fibrosis. The unique effects of Sal B were: angiogenesis and augmented VEGF expression in the border and remote noninfarcted LV area. These results suggest that Sal B and benazepril exerted beneficial cardioprotective effects. However, Sal B enforced some different modality than benazepril, which might improve myocardial microcirculation by augmenting VEGF expression and promoting angiogenesis besides similar effects to benazepril.

Transport of salicylate in proximal tubule (S2 segment) isolated from rabbit kidney

International Nuclear Information System (INIS)

Schild, L.; Roch-Ramel, F.

1988-01-01

The secretory and the reabsorptive transport of salicylate was studied in the isolated and perfused rabbit proximal tubule (S 2 segment). Salicylate secretion (J sal b→l ) fulfilled the criteria for a carrier-mediated transport system: J sal b→l was saturable, was reversibly inhibited by probenecid, and occurred against a concentration gradient. The K m and V max for this secretory transport were 80 μM and 3,200 fmol·min -1 ·mm -1 , respectively. At luminal pH of 7.4 and 6.6, salicylate reabsorption (J sal l→b ) was low. J sal l→b was stimulated by increasing the bath Pco 2 or by removing basolateral HCO 3 - ; J sal l→b was inhibited by ethoxyzolamide and by SITS in the bath. The results indicate that salicylate reabsorption depends on H + secretion, consistent with reabsorption by simple nonionic diffusion. When salicylate was present in the lumen only, J sal l→b increased after inhibition of the secretory transport by adding ouabain or probenecid in the bath or by lowering the bath temperature. These results are compatible with luminal recycling of salicylate, and suggest the presence of a mediated secretory transporter located at the luminal membrane

Geometric microliths as chronological and cultural markers in the Sado shell middens? Reflections from Amoreiras (Alcácer do Sal, Portugal

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Diana Nukushina

2015-02-01

Full Text Available The production of geometric microliths from bladelets has been identified as one of the main strategies of lithic production during the Late Mesolithic in southwestern Portugal. The Sado shell middens generally possess an abundance of these tools, similarly to sites found in other regions. However, systematic lithic studies are still scarce. In this work, we discuss the value of the geometric microliths as chronological and cultural markers, through the analysis of lithic remains from Amoreiras shell midden (Alcácer do Sal. First, a formal characterization of this assemblage is performed. Second, a diachronic and cultural perspective of these materials in the Sado shell middens is provided. Finally, a comparison with other Late Mesolithic and the Early Neolithic assemblages from southwestern Iberia is presented. A set of lithic remains from Amoreiras, which was recovered in the 1950s and 1960s, was subject to a techno-typological analysis, following the assumptions of the ‘chaîne opératoire’. Also, a statistical analysis, including variance analysis, was performed. This work shows that the geometric microliths from Amoreiras clearly represent one of the main purposes for the debitage at this site, which presents an outstanding typological and size uniformity. The characteristics found by this study suggest the existence of a well-standardized production of geometric microliths. This production scheme would be more economic in terms of raw material requirements and production time-effort. The material and chronometrical data from Amoreiras contradicts the cultural uniformity perspective for this specific site and for the Sado shell middens in general. Moreover, in light of the presented data, a strict chrono-cultural significance of the segment dominance is difficult to sustain. Despite the standardized production and the importance given to geometric microliths, the data provided by the forms and their variations is still insufficient for

Anaerobic Degradation of Marine Algae, Seagrass and Tropical Climbing Vines to Produce a Renewable Energy Source and the Analysis of Their Anaerobic Microbial Communities

Science.gov (United States)

2013-01-01

specific mechanisms and enzymes as a result of their complex structure. For these reasons there have been searches for other biomasses that may...Te’o, V., Saul, D., Morgan, H. 1999. Molecular diversity of thermophilic cellulolytic and hemicellulolytic bacteria. Microbiology Ecology, 28:99-110...lyase genes from deep-sea strains of Vibrio and Agarivorans and characterization of a new Vibrio enzyme . Marine Biotechnology, 12:526-533. Ugwu, C

Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice

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Ledford Dennis

2006-05-01

Full Text Available Abstract Background Respiratory syncytial virus (RSV infection is the major cause of bronchiolitis in infants and is a risk factor for the development of asthma. Allergic asthmatics are more susceptible to RSV infection and viral exacerbation. Methods Since the effectiveness of corticosteroids in treating RSV infection has been controversial, we tested fluticasone propionate (FP and salmeterol (Sal alone versus FP plus Sal (FPS on RSV-induced airway inflammation. Mice were sensitized and challenged with ovalbumin (OVA and infected with RSV. Following infection they were treated with FP, Sal, or FPS intranasally and airway hyperreactivity (AHR, inflammation and RSV titers were examined. Results The group treated with FPS showed significantly lower AHR compared to the group treated with FP or Sal alone. The group treated with FP alone showed slightly decreased (non-significant AHR compared to controls. Treatment with FPS resulted in significant decreases in the percentage of eosinophils and neutrophils in bronchoalveolar lavage fluid and in lung pathology compared to FP or Sal. FP alone decreased eosinophils but not neutrophils or lymphocytes, while Sal alone decreased eosinophils and neutrophils but not lymphocytes. FPS treatment of mice infected with RSV in the absence of allergen sensitization resulted in a 50% decrease of RSV titer in the lung and a reduction in neutrophils compared to FP or Sal. Conclusion Together, these results indicate that fluticasone in combination with salmeterol is a more effective treatment for decreasing airway hyperreactivity and inflammation than either of them alone in allergen-sensitized, RSV-infected mice.

Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis.

Science.gov (United States)

Chen, YongPing; Wei, QianQian; Chen, XuePing; Li, ChunYu; Cao, Bei; Ou, RuWei; Hadano, Shinji; Shang, Hui-Fang

2016-01-01

Accumulating evidence indicates that miRNAs play an important role in the development of amyotrophic lateral sclerosis (ALS). Most of previous studies on miRNA dysregulation in ALS focused on the alterative expression in ALS animal model or in limited samples from European patients with ALS. In the present study, the miRNA expression profiles were investigated in Chinese ALS patients to explore leukocytes miRNAs as a potential biomarker for the diagnosis of ALS. We analyzed the expression profiles of 1733 human mature miRNAs using microarray technology in leukocytes obtained from 5 patients with sporadic ALS (SALS) and 5 healthy controls. An independent group of 83 SALS patients, 24 Parkinson's disease (PD) patients and 61 controls was used for validation by real-time polymerase chain reaction assay. Area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. In addition, target genes and signaling information of validated differential expression miRNAs were predicted using Bioinformatics. Eleven miRNAs, including four over-expressed and seven under-expressed miRNAs detected in SALS patients compared to healthy controls were selected for validation. Four under-expressed microRNAs, including hsa-miR-183, hsa-miR-193b, hsa-miR-451, and hsa-miR-3935, were confirmed in validation stage by comparison of 83 SALS patients and 61 HCs. Moreover, we identified a miRNA panel (hsa-miR-183, hsa-miR-193b, hsa-miR-451, and hsa-miR-3935) having a high diagnostic accuracy of SALS (AUC 0.857 for the validation group). However, only hsa-miR-183 was significantly lower in SALS patients than that in PD patients and in HCs, while no differences were found between PD patients and HCs. By bioinformatics analysis, we obtained a large number of target genes and signaling information that are linked to neurodegeneration. This study provided evidence of abnormal miRNA expression patterns in the peripheral blood leukocytes of SALS patients. Leukocytes

Aberration of miRNAs Expression in leukocytes from sporadic amyotrophic lateral sclerosis

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Yongping Chen

2016-08-01

Full Text Available Background: Accumulating evidence indicates that miRNAs play an important role in the development of amyotrophic lateral sclerosis (ALS. Most of previous studies on miRNA dysregulation in ALS focused on the alterative expression in ALS animal model or in limited samples from European patients with ALS. In the present study, the miRNA expression profiles were investigated in Chinese ALS patients to explore leukocytes miRNAs as a potential biomarker for the diagnosis of ALS.Methods: We analyzed the expression profiles of 1733 human mature miRNAs using microarray technology in leukocytes obtained from 5 patients with sporadic ALS (SALS and 5 healthy controls. An independent group of 83 SALS patients, 24 Parkinson’s disease (PD patients and 61 controls was used for validation by real-time polymerase chain reaction assay. Area under the receiver operating characteristic curve (AUC was used to evaluate diagnostic accuracy. In addition, target genes and signaling information of validated differential expression miRNAs were predicted using Bioinformatics.Results: Eleven miRNAs, including four over-expressed and seven under-expressed miRNAs detected in SALS patients compared to healthy controls were selected for validation. Four under-expressed microRNAs, including hsa-miR-183, hsa-miR-193b, hsa-miR-451 and hsa-miR-3935, were confirmed in validation stage by comparison of 83 SALS patients and 61 HCs. Moreover, we identified a miRNA panel (hsa-miR-183, hsa-miR-193b, hsa-miR-451 and hsa-miR-3935 having a high diagnostic accuracy of SALS (AUC 0.857 for the validation group. However, only hsa-miR-183 was significantly lower in SALS patients than that in PD patients and in HCs, while no differences were found between PD patients and HCs. By bioinformatics analysis, we obtained a large number of target genes and signaling information that are linked to neurodegeneration. Conclusion: This study provided evidence of abnormal miRNA expression patterns in the

Synthetic Aperture Imaging Polarimeter: Postprint

Science.gov (United States)

2010-02-01

mechanical design of the SAlP prototype revol .... es around the concept of a modular array. The modular aspect allows for the array to be built in...imagery of source . The top row images are of the actual fringe pattern incident on the SAlP prototype array. These pictures were taken through the...processed images associated with each of the inputs. The results demonstrated that the SAlP prototype array works in conjunction with the algorithm

Comparative acute nephrotoxicity of salicylic acid, 2,3-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid in young and middle aged Fischer 344 rats.

Science.gov (United States)

McMahon, T F; Stefanski, S A; Wilson, R E; Blair, P C; Clark, A M; Birnbaum, L S

1991-03-11

Experimental evidence suggests that the oxidative metabolites 2,3- and 2,5-dihydroxybenzoic acid (DIOH) may be responsible for the nephrotoxicity of salicylic acid (SAL). In the present study, enzymuria in conjunction with glucose (GLU) and protein (PRO) excretion were used as endpoints to compare the relative nephrotoxicity of SAL with 2,3- and 2,5-DIOH. In addition, the effect of age on enzymuria and GLU and PRO excretion following treatment with SAL or 2,3- and 2,5-DIOH was investigated because the elderly are at greater risk for SAL-induced nephrotoxicity. Three and 12-month male Fischer 344 rats were administered either no treatment, vehicle, SAL, 2,3-DIOH, or 2,5-DIOH at 500 mg/kg p.o. in 5 ml/kg corn oil/DMSO (5:1). Effects of these treatments on functional integrity of renal tissue was assessed from 0--72 h after dosing by measurement of urinary creatinine, GLU, and PRO, as well as excretion of proximal and distal tubular renal enzymes. Enzymes measured as indicators of proximal tubular damage were N-acetyl-beta-glucosaminidase (NAG), gamma glutamyltransferase (GGT), alanine aminotransferase (ALT), and alkaline phosphatase (AP), while urinary lactate dehydrogenase (LD) and aspartate aminotransferase (AST) were measured as indicators of distal tubular damage. In comparison to 3-month vehicle-treated rats, 2,3- and 2,5-DIOH caused a significant increase between 0-8 h in excretion of urinary GLU and activities of AST, NAG, and LD, with peak effects occurring between 4-8 h. Toxic effects of either metabolite were not evident beyond 24 h, and toxicity of 2,5-DIOH was significantly greater in comparison to 2,3-DIOH. SAL treatment resulted in similar effects on enzymuria as well as GLU and PRO excretion, but peak effects did not occur until 16-24 h, and often persisted until 72 h after dosing. Maximal enzymuria in response to SAL treatment was significantly greater in 12- vs. 3-month rats for AST, NAG, and LD. In response to 2,3-DIOH treatment, the maximal

Composição e dinâmica da avifauna da usina eólica da praia da Pedra do Sal, Delta do Parnaíba, Piauí, Brasil

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Anderson Guzzi

2015-06-01

Full Text Available RESUMO O impacto dos parques eólicos sobre as aves é um dos temas menos estudados no Brasil, o que contrasta com a importância dessa nova fonte de energia renovável. O presente estudo buscou caracterizar a composição e dinâmica ecológica das espécies de aves residentes e migratórias presentes na área da Usina Eólica da Pedra do Sal, em Parnaíba, Estado do Piauí. O estudo foi desenvolvido por meio de trinta e três amostragens distribuídas em dois ciclos sazonais completos (setembro de 2011 a agosto de 2013, através do método do ponto de escuta, dispostos na base de cada um dos aerogeradores. Foram registrados 6.843 contatos de aves pertencentes a 67 espécies distribuídas em 22 famílias e 13 ordens, e a espécie com maior número de contatos foi a batuíra-de-coleira (Charadrius collaris. As categorias tróficas predominantes foram as das aves insetívoras, representadas por 18 espécies, seguidas pelas aves que se alimentam de invertebrados aquáticos (17 espécies. A maioria das aves registradas é de ambiente aquático. Durante o desenvolvimento desse estudo não foram registradas colisões entre as aves e os aerogeradores.

A relação entre educação pré-primária, salários, escolaridade e proficiência escolar no Brasil

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Andréa Zaitune Curi

2009-12-01

Full Text Available Neste artigo analisamos a relação entre a educação pré-primária (creche e pré-escola e os salários, a escolaridade e a proficiência escolar no Brasil, utilizando dados da PPV e do SAEB. Os resultados mostram que a pré-escola tem uma relação positiva e significante com a conclusão dos quatro ciclos escolares, com efeito marginal crescente nos três primeiros, e que a creche tem relação positiva e significante apenas com a conclusão do ensino médio e do ensino universitário. Além disso, a pré-escola está associada com um aumento de 1 ano e meio de escolaridade e de 16% na renda, independentemente da sua relação com a educação. Finalmente, os alunos que frequentaram a pré-escola têm um desempenho escolar melhor, medido por testes de proficiência, na 4ª e 8ª séries do ensino fundamental e na 3ª série do ensino médio.This paper examines the relations between daycare and pre-school, wages, education and school performance in Brazil using a survey with detailed information on education and earnings trajectories. We find that pre-school attendance has a positive relationship with primary, middle school, high school and college conclusion, even when we condition on parental education. Pre-schooling is associated with increases of 1.5 year in schooling and about 27% in wages. Pre-schooling is also associated with increases in standardized test scores in the 4th, 8th and 11th grades.

Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1α-Sirt3 Axis

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Guanhua Du

2012-09-01

Full Text Available Salvianolic acid A (SalA is one of the main efficacious, water-soluble constituents of Salvia miltiorrhiza Bunge. This study investigated the protective effects of SalA on peripheral nerve in diabetic rats. Administration of SalA (0.3, 1 and 3 mg/kg, ig was started from the 5th week after strepotozotocin (STZ60 mg/kg intraperitoneal injection and continued for 8 weeks. Paw withdrawal mechanical threshold (PWMT and motor nerve conduction velocity (MNCV were used to assess peripheral nerve function. The western blot methods were employed to test the expression levels of serine-threonine liver kinase B1 (LKB1, AMP-activated protein kinase (AMPK, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α, silent information regulator protein3 (sirtuin 3/Sirt3 and neuronal nitric oxide synthase (nNOS in sciatic nerve. Results showed that SalA administration could increase PWMT and MNCV in diabetic rats; reduce the deterioration of sciatic nerve pathology; increase AMPK phosphorylation level, up-regulate PGC-1α, Sirt3 and nNOS expression, but had no influence on LKB1. These results suggest that SalA has protective effects against diabetic neuropathy. The beneficial effects of SalA on peripheral nerve function in diabetic rats might be attributed to improvements in glucose metabolism through regulation of the AMPK-PGC1α-Sirt3 axis.

Influences of the Saharan Air Layer on the Formation and Intensification of Hurricane Isabel (2003): Analysis of AIRS data and Numerical Simulation

Science.gov (United States)

Wu, L.; Braun, S. A.

2006-12-01

Over the past two decades, little advance has been made in prediction of tropical cyclone intensity while substantial improvements have been made in forecasting hurricane tracks. One reason is that we don't well understand the physical processes that govern tropical cyclone intensity. Recent studies have suggested that the Saharan Air Layer (SAL) may be yet another piece of the puzzle in advancing our understanding of tropical cyclone intensity change in the Atlantic basin. The SAL is an elevated mixed layer, forming as air moves across the vast Sahara Desert, in particular during boreal summer months. The SAL contains warm, dry air as well as a substantial amount of mineral dust, which can affect radiative heating and modify cloud processes. Using the retrieved temperature and humidity profiles from the AIRS suite on the NASA Aqua satellite, the SAL and its influences on the formation and intensification of Hurricane Isabel (2003) are analyzed and simulated with MM5. When the warmth and dryness of the SAL (the thermodynamic effect) is considered by relaxing the model thermodynamic state to the AIRS profiles, MM5 can well simulate the large-scale flow patterns and the activity of Hurricane Isabel in terms of the timing and location of formation and the subsequent track. Compared with the experiment without nudging the AIRS data, it is suggested that the simulated SAL effect may delay the formation and intensification of Hurricane Isabel. This case study generally confirms the argument by Dunion and Velden (2004) that the SAL can suppress Atlantic tropical cyclone activity by increasing the vertical wind shear, reducing the mean relative humidity, and stabilizing the environment at lower levels.

Reactivity of paraquat with sodium salicylate: Formation of stable complexes

International Nuclear Information System (INIS)

Dinis-Oliveira, Ricardo Jorge; Guedes de Pinho, Paula; Ferreira, Antonio Cesar Silva; Silva, Artur M.S.; Afonso, Carlos; Bastos, Maria de Lourdes; Remiao, Fernando; Duarte, Jose Alberto; Carvalho, Felix

2008-01-01

Sodium salicylate (NaSAL) has been shown to be a promising antidote for the treatment of paraquat (PQ) poisonings. The modulation of the pro-oxidant and pro-inflammatory pathways, as well as the anti-thrombogenic properties of NaSAL are probably essential features for the healing effects provided by this drug. Nevertheless, a possible direct chemical reactivity between PQ and NaSAL is also a putative pathway to be considered, this hypothesis being the ground of the present study. In accordance, it is shown, for the first time that PQ and NaSAL react immediately in aqueous medium and within 2-3 min in the solid state. Photographs and scanning electron photomicrographs indicated that a new chemical entity is formed when both compounds are mixed. This assumption was corroborated by the evaluation of the melting point, and through several analytical techniques, namely ultraviolet/visible spectroscopy, nuclear magnetic resonance spectroscopy, gas chromatography/mass spectrometry/mass spectrometry (GC/MS/MS), liquid chromatography/electrospray ionization/mass spectrometry/mass spectrometry (LC/ESI/MS/MS) and infrared spectroscopy, which revealed that stable charge-transfer complexes are formed when PQ is mixed with NaSAL. LC/ESI/MS/MS allowed obtaining the stoichiometry of the charge-transfer complexes. In order to increase resolution, single value decomposition, acting as a filter, showed that the charge-transfer complexes with m/z 483, 643 and 803 correspond to the pseudo-molecular ions, respectively 1:2, 1:3 and 1:4 (PQ:NaSAL). In conclusion, these results provided a new and important mechanism of action of NaSAL against the toxicity mediated by PQ

FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.

Science.gov (United States)

Deng, Han-Xiang; Zhai, Hong; Bigio, Eileen H; Yan, Jianhua; Fecto, Faisal; Ajroud, Kaouther; Mishra, Manjari; Ajroud-Driss, Senda; Heller, Scott; Sufit, Robert; Siddique, Nailah; Mugnaini, Enrico; Siddique, Teepu

2010-06-01

Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration. Most cases of ALS are sporadic (SALS), but about 5 to 10% of ALS cases are familial (FALS). Recent studies have shown that mutations in FUS are causal in approximately 4 to 5% of FALS and some apparent SALS cases. The pathogenic mechanism of the mutant FUS-mediated ALS and potential roles of FUS in non-FUS ALS remain to be investigated. Immunostaining was performed on postmortem spinal cords from 78 ALS cases, including SALS (n = 52), ALS with dementia (ALS/dementia, n = 10), and FALS (n = 16). In addition, postmortem brains or spinal cords from 22 cases with or without frontotemporal lobar degeneration were also studied. In total, 100 cases were studied. FUS-immunoreactive inclusions were observed in spinal anterior horn neurons in all SALS and FALS cases, except for those with SOD1 mutations. The FUS-containing inclusions were also immunoreactive with antibodies to TDP43, p62, and ubiquitin. A fraction of tested FUS antibodies recognized FUS inclusions, and specific antigen retrieval protocol appeared to be important for detection of the skein-like FUS inclusions. Although mutations in FUS account for only a small fraction of FALS and SALS, our data suggest that FUS protein may be a common component of the cellular inclusions in non-SOD1 ALS and some other neurodegenerative conditions, implying a shared pathogenic pathway underlying SALS, non-SOD1 FALS, ALS/dementia, and related disorders. Our data also indicate that SOD1-linked ALS may have a pathogenic pathway distinct from SALS and other types of FALS.

Emulsinio linimento su arbatmedžio eteriniu aliejumi gamybos technologija ir vertininmas

OpenAIRE

Rimkuvienė, Dovilė

2017-01-01

Dovilė Rimkuvienė. Master's thesis,, To produce and assessment on a emulsion of liniment with tea tree essential oil. Research supervisor doc. dr. Saulė Velžienė. Lithuanian University of Health Sciences Pharmaceutical Technology and Social Pharmacy Department. - Kaunas. Aim of research- to produce liniment of emulsion with tea tree essential oil, selecting the optimum technology and evaluate it. Task of research: 1. Based on the accumulated scientific literature and practical exper...

Nalmefene and alcohol dependence: a new approach or the same old unacceptable marketing?

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Braillon A

2015-06-01

Full Text Available Alain Braillon,1,* Bernard Granger,2,*1Alcohol Treatment Unit, University Hospital, Amiens, France; 2Psychiatry, Tarnier Hospital (AP-HP, Paris, France*Both authors contributed equally to this work“A great deal of intelligence can be invested in ignorance when the need for illusion is deep”. Saul BellowPaille and Martini’s review on nalmefene for alcohol dependence deserves some comment.1 Read the original article  

Magneto and spectral behaviour of lanthanide(III) perchlorate complexes of n-isonicotinamidoanisalaldimine

International Nuclear Information System (INIS)

Agarwal, R.K.; Agarwal, Himanshu; Sarin, R.K.

1996-01-01

A new series of lanthanide(III) perchlorate complexes of N-isonicotinamidoanisalaldimine (INH-SAL) with the general composition (Ln(INH-SAL) 4 )(ClO) 4 ) 3 (Ln=La, Pr, Nd, Sm, Gd, Tb or Dy) were synthesized and characterized by elemental analyses, conductance, molecular weight, infrared and electronic spectral data. INH-SAL acts as a bidentate (N, O) chelating agents. The tentative coordination number eight has been assigned. Thermal behaviour of some representative chelates has also been investigated. (author). 14 refs., 2 tabs

Development of smart active layer sensor

International Nuclear Information System (INIS)

Lee, Young Sup; Lee, Sang Il; Yoon, Dong Jin; Kwon, Jae Hwa

2004-01-01

Structural health monitoring (SHM) is a new technology that will be increasingly applied at the industrial field as a potential approach to improve cost and convenience of structural inspection. Recently, the development of smart sensor is very active for real application. This study has focused on preparation and application study of SAL sensor. In order to detect elastic wave, smart piezoelectric sensor, SAL, is fabricated by using a piezoelectric element, shielding layer and protection layer. This protection layer plays an important role in a patched network of distributed piezoelectric sensor and shielding treatment. Four types of SAL sensor are designed/prepared/tested, and these details will be discussed in the paper. In this study, SAL sensor can be feasibly applied to perform structural health monitoring and to detect damage sources which result in elastic waves.

AKSIE: BEESVLEISPRODUKSIE TOT DIE JAAR 2OO3

African Journals Online (AJOL)

comminuted meats"' . Komponente van die lyfde kwart sal verbruikers- waarde kry. o verpakking en aanbieding sal meer gesofistikeerd moet wees om doeltreffende rakleeftyd en higiene te verseker en die verbruiker meer geleentheid tot ondersoek ...

Īstermiņa hidroloģisko prognožu salīdzinošā analīze 2013. un 2014.gadu hidroloģiskajās fāzēs: Irbes, Abavas, Bērzes, Gaujas, Ogres un Dubnas upju basenu piemēros

OpenAIRE

Zubaničs, Andrejs

2015-01-01

Maģistra darba tēma ir „Īstermiņa hidroloģisko prognožu salīdzinošā analīze 2013. un 2014. gadu hidroloģiskajās fāzēs: Irbes, Abavas, Bērzes, Gaujas, Ogres un Dubnas upju baseinu piemēros”. Darba mērķis ir novērtēt, kura skaitliskā meteoroloģiskā modeļa HIRLAM vai ECMWF laika apstākļu prognozes ļauj modelēt precīzākās īstermiņa hidroloģiskās prognozes sešiem pētītajiem Latvijas upju baseiniem. Literatūras analīzē aplūkota hidroloģiskā modelēšana, modeļu veidi un to pielietojums hidroloģisk...

[Toxicity of the combination of salinomycin and tiamulin in swine].

Science.gov (United States)

Wendt, M; Büsing, S; Bollwahn, W

1997-09-01

The toxicity of the combination of salinomycin (sal.) and tiamulin (tia.) was investigated in dependence upon dosage and feeding method. In addition the efficacy of a safe dose for prophylactic treatment of dysentery was controlled. Following feed medications were tested for toxic effects in pigs: a) 3 mg sal. + 5 mg tia./kg BW, b) 3 mg sal. + 3 mg tia./kg BW, c) 3 mg sal. + 1 mg tia./kg BW, d) 3 mg sal./kg BW, e) 10 mg tia./kg BW, f) 30 mg tia./kg BW. The daily dose was given for 2 weeks by restricted feeding (twice a day) either as bolus or mixed in the whole ration or by feeding ad libitum. Animals were controlled for clinical symptoms and activities of creatine phosphokinase (CK) and aspartate aminotransferase (ASAT) were evaluated daily. Main clinical signs of poisoning were loss of appetite and locomotor disturbances and could be noticed for dosages of 8, 6 and 4 mg sal. + tia./kg BW. Activities of CK and ASAT were increased dose-related, the feeding method also had an influence on the degree of intoxication. Some animals showed locomotor disturbances without any corresponding changes of CK and ASAT levels. Single pigs remaining without any symptoms even at high dosage pointed to differences in individual susceptibility. Toxicity was not found to be age dependent. Feed medication with 60 ppm sal. + 20 ppm tia. (feeding ad libitum) did not result in any signs of toxicity, however, the transmission of Serpulina hyodysenteriae from infected pigs to healthy, treated control animals could not be inhibited efficiently. Therefore the simultaneous application of salinomycin and tiamulin should be avoided generally, because the risk of intoxication is high and subtherapeutical dosage has an insufficient effectiveness against Serpulina hyodysenteriae.

Evidence-Based Practice in Liposuction.

Science.gov (United States)

Collins, Patrick S; Moyer, Kurtis E

2018-01-24

The goal of this study is to examine the existing peer reviewed literature comparing modern adjunctive techniques in liposuction including laser-assisted liposuction (LAL) and ultrasound-assisted liposuction (UAL) to standard suction-assisted liposuction (SAL). We intend to interpret these findings into a literature-based clinical application to influence practice patterns. A literature review was conducted using a keyword search in PubMed. Keyword search items included liposuction, lipoplasty, suction assisted liposuction, ultrasound assisted liposuction, laser assisted liposuction, tumescent, liposuction comparison, liposuction review, and combinations therein. Exclusion criteria included articles with a primary focus on histologic effects of energy devices, primary animal models, primary opinion papers with no reference to available data, and industry-sponsored publications. Inclusion criteria included articles with direct comparison of liposuction modalities, randomized or blinded studies, and studies with objective outcomes. Twenty-five articles that met the inclusion criteria comparing SAL to UAL or LAL out of 9972 articles identified were obtained. The selected literature was assigned into 3 categories: evidence demonstrating an advantage of 1 modality (SAL, UAL, or LAL) over another, evidence that showed no benefit of 1 modality over another, and evidence that demonstrated risks of complications of 1 modality over another. The benefits of UAL and LAL over SAL include the following: (1) UAL over SAL in the treatment of gynecomastia, (2) LAL and UAL over SAL with decreased hemoglobin/hematocrit in high-volume lipoaspirates, and (3) LAL over SAL with skin tightening in select areas specifically the submental area. Otherwise, the literature demonstrates equivocal results among the described techniques with no clear benefit to set one apart from the other. There appears to be no demonstrable added benefit to the addition of either UAL or LAL that would urge a

Comparison of the sedative effects of nalbuphine and butorphanol, alone or in combination with acepromazine in dogs.

Science.gov (United States)

Gomes, Viviane H; Oliveira, Renato Ls; Marques, Juliana Lr; Coelho, Cassia Mm; Silva, Marta Fa

2018-01-01

To compare sedation and effects on heart rate (HR), mean arterial pressure (MAP) and respiratory rate (f R ) of nalbuphine and butorphanol, alone or combined with acepromazine in dogs. Prospective, randomized experimental trial. Eight healthy Beagle dogs, aged (mean ± standard deviation) 3.4 ± 0.5 years and weighing 11.0 ± 1.3 kg. Each dog was treated four times: physiological saline (1 mL) combined with nalbuphine (0.5 mg kg -1 ; SAL-NAL) or butorphanol (0.15 mg kg -1 ; SAL-BUT), and acepromazine (0.05 mg kg -1 ) combined with nalbuphine (0.5 mg kg -1 ; ACP-NAL) or butorphanol (0.15 mg kg -1 ; ACP-BUT), intravenously (IV). The degree of sedation, assessed by a numeric descriptive scale (NDS) and simple numerical scale (SNS), HR, MAP, f R and rectal temperature (RT), were recorded before and 20 minutes after administration of saline or acepromazine, then 15, 30, 60, 90 and 120 minutes after nalbuphine or butorphanol. Values were compared with baseline and among treatments. Mild sedation was recorded for SAL-NAL and SAL-BUT, and moderate sedation for ACP-NAL and ACP-BUT. NDS and SNS scores were higher for SAL-BUT and ACP-BUT at some time points when compared with SAL-NAL and ACP-NAL, respectively (p 0.5 °C) compared with SAL-NAL (38.0 ± 0.5 °C) at 60-120 minutes (p < 0.05). Butorphanol promoted a higher sedative effect than nalbuphine when alone and combined with acepromazine. IV administration of nalbuphine or butorphanol, with or without acepromazine, at the doses studied, resulted in minimal decreases in MAP, HR, f R and RT. Copyright © 2017. Published by Elsevier Ltd.

Terbinafine Resistance Mediated by Salicylate 1-Monooxygenase in Aspergillus nidulans

Science.gov (United States)

Graminha, Marcia A. S.; Rocha, Eleusa M. F.; Prade, Rolf A.; Martinez-Rossi, Nilce M.

2004-01-01

Resistance to antifungal agents is a recurring and growing problem among patients with systemic fungal infections. UV-induced Aspergillus nidulans mutants resistant to terbinafine have been identified, and we report here the characterization of one such gene. A sib-selected, 6.6-kb genomic DNA fragment encodes a salicylate 1-monooxygenase (salA), and a fatty acid synthase subunit (fasC) confers terbinafine resistance upon transformation of a sensitive strain. Subfragments carrying salA but not fasC confer terbinafine resistance. salA is present as a single-copy gene on chromosome VI and encodes a protein of 473 amino acids that is homologous to salicylate 1-monooxygenase, a well-characterized naphthalene-degrading enzyme in bacteria. salA transcript accumulation analysis showed terbinafine-dependent induction in the wild type and the UV-induced mutant Terb7, as well as overexpression in a strain containing the salA subgenomic DNA fragment, probably due to the multicopy effect caused by the transformation event. Additional naphthalene degradation enzyme-coding genes are present in fungal genomes, suggesting that resistance could follow degradation of the naphthalene ring contained in terbinafine. PMID:15328121

Die Voortrekker-Monument

Directory of Open Access Journals (Sweden)

Gerard Moerdyk

1938-03-01

Full Text Available Die Eeufeesjaar is vir die Afrikaner ’n tydperk van besieling. Nog nooit sedert die ontstaan van ons volk het een enkele gebeurtenis soveel nasietrots gewek as die honderdjarige herdenking van die Groot Trek. Vir die eerste keer in ons geskiedenis voel ons ons nie meer Kapenaars, Vrystaters, Natalers, en Transvalers nie, maar Afrikaners, saamgesnoer deur die tradisies van ’n selfstandige kultuurvolk. Wanneer die klimaks van die Ossewatrek met die hocksteenlegging van die Voortrekker-Monument bereik word, sal die besieling nie uitsterf nie, die krag wat geskep is sal bly voortgroei tot ’n onweerstaanbare mag. Die Afrikaner sal homself vind, en as die Monument na sowat vyf jaar onthul word, sal die saad wat in hierdie jaar gesaai is, tot voile rypheid gekom het. Dan sal die Monument self tot die volk spreek; intussen egter, is dit wenslik, nee noodsaaklik selfs, om die Monument aan die Afrikaners te verklaar, om ‘n uiteensetting te gee van die noodsaaklikheid van so ’n Monument, sowel as om die motief te verduidelik wat as inspirasie gedien het vir die ontwerpdaar van.

Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis.

Science.gov (United States)

Coppedè, Fabio; Migheli, Francesca; Lo Gerfo, Annalisa; Fabbrizi, Maria Rita; Carlesi, Cecilia; Mancuso, Michelangelo; Corti, Stefania; Mezzina, Nicoletta; del Bo, Roberto; Comi, Giacomo P; Siciliano, Gabriele; Migliore, Lucia

2010-01-01

The aim of the present study was to investigate the possible contribution of three common functional polymorphisms in the DNA repair protein X-ray repair cross-complementing group 1 (XRCC1), namely Arg194Trp (rs1799782), Arg280His (rs25489) and Arg399Gln (rs25487), to sporadic amyotrophic lateral sclerosis (SALS). We genotyped 206 Italian SALS patients and 203 matched controls for XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms by means of PCR/RFLP technique, searching for association between any of the studied polymorphisms and disease risk, age and site of onset. We observed a statistically significant difference in XRCC1 Gln399 allele frequencies between SALS cases and controls (0.39/0.28; p=0.001). The present study suggests that the XRCC1 Arg399Gln polymorphism might contribute to SALS risk.

Crystallization and preliminary X-ray diffraction analysis of salutaridine reductase from the opium poppy Papaver somniferum

International Nuclear Information System (INIS)

Higashi, Yasuhiro; Smith, Thomas J.; Jez, Joseph M.; Kutchan, Toni M.

2010-01-01

Recombinant P. somniferum salutaridine reductase (SalR) was purified and crystallized with NADPH using the hanging-drop vapor-diffusion method. Crystals of the SalR–NADPH complex diffracted X-rays to a resolution of 1.9 Å. The opium poppy Papaver somniferum is the source of the narcotic analgesics morphine and codeine. Salutaridine reductase (SalR; EC 1.1.1.248) reduces the C-7 keto group of salutaridine to the C-7 (S)-hydroxyl group of salutaridinol in the biosynthetic pathway that leads to morphine in the opium poppy plant. P. somniferum SalR was overproduced in Escherichia coli and purified using cobalt-affinity and size-exclusion chromatography. Hexagonal crystals belonging to space group P6 4 22 or P6 2 22 were obtained using ammonium sulfate as precipitant and diffracted to a resolution of 1.9 Å

National Program for Inspection of Non-Federal Dams. Williams Pond Dam (CT 00551), Thames River Basin, Lebanon, Connecticut. Phase I Inspection Program.

Science.gov (United States)

1978-10-01

GRA&I UnTucea B WILLIAMS POND DAM ~~1Z~ CT 00551 _ Distribution/ Availabilit Y Codes Avail and/or Dis~tj pecialS RIVER BASIN ~lIILEBANON, COXNNECTICUT...Inspection Report. Alternatives to these recommendations r 1 would include reducing the Williams Pond water levels during expected periods of intense storm...Materials Branch Engi’neering Division FRED J. VNS. Jr., Member Chief, De ’ggn Branch Engineering Division SAUL COOPER, -r Chief, Water Control Branch

Characterization of the nest site preferences of Saltmarsh and Nelson's Sparrows, and hybrids

Science.gov (United States)

Saltmarsh Sparrows (hereafter SALS) are named on the National Audubon Society’s current WatchList as a species of global conservation concern (National Audubon Society 2007). Anthropogenic climate change is perhaps the largest threat to SALS populations because sea level ri...

Administrative claims analysis of asthma-related health care utilization for patients who received inhaled corticosteroids with either montelukast or salmeterol as combination therapy.

Science.gov (United States)

Allen-Ramey, Felicia C; Bukstein, Don; Luskin, Allan; Sajjan, Shiva G; Markson, Leona E

2006-05-01

To compare asthma-related health care resource utilization among a matched cohort of asthma patients using inhaled corticosteroids (ICSs) plus either montelukast (MON) or salmeterol (SAL) as combination therapy for asthma, during a time prior to the availability of fixed-dose combinations of ICS/SAL. A retrospective analysis using the PHARMetrics patient-centric claims database was conducted for the period preceding the market introduction of combination fluticasone-SAL in September 2000. Patients had to meet the following criteria for inclusion in the study: they had to be between the ages of 4 and 55 years; they had to have been continuously enrolled for 2 years; they had to have initiated ICS/MON or ICS/SAL therapy between July 1, 1998, and June 30, 1999; and they had to have had either (a) a diagnosis of asthma (based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes of 493.xx) for 2 outpatient visits, 1 or more emergency department (ED) visits, or 1 or more hospitalizations within 1 year or (b) pharmacy claim records that contained a National Drug Code for an antiasthma medication (betaagonist, theophylline, ICS, cromolyn, or leukotriene) 2 or more times within 1 year. ICS/MON and ICS/SAL patients were matched 1 to 1 on age and propensity score. Outcomes included asthma-related hopitalizations and ED visits with ICD-9-CM codes of 493.xx, and oral corticosteroid (OCS) fills and short-acting beta-agonist (SABA) fills. Multivariate regression analyses were performed. Subgroup analyses based on sequential or concurrent initiation of combination therapy were also conducted. A total of 1,216 patients were matched (ICS/MON = 608; ICS/SAL= 608). Decreased odds of ED visits and/or hospitalizations were observed with ICS/MON (adjusted odds ratio [OR] = 0.58; 95% confidence interval [CI], 0.35- 0.98) versus ICS/SAL. The odds of postindex OCS fills were not different for ICS/MON and ICS/SAL patients (adjusted OR = 1.04; 95

Protective Effects of Salubrinal on Liver Injury in Rat Models of Brain Death

Institute of Scientific and Technical Information of China (English)

Tao Wang; Shui-Jun Zhang; Sheng-Li Cao; Wen-Zhi Guo; Bing Yan; Hong-Bo Fang

2015-01-01

Background:Previous studies have indicated that endoplasmic reticulum stress participates in and mediates liver injury and apoptosis in brain-dead (BD) rats.In this study,we observed the effect ofsalubrinal (Sal,Sigma,USA) on liver cells in BD rats and explored its relevant mechanisms.Methods:Thirty Sprague-Dawley rats were equally randomized into three groups:BD group,Sal group,and DMSO group.The BD models were established by increasing intracranial pressure in a modified,slow,and intermittent way.In the drug groups,Sal was administered l h before the induction of BD.After modeling was completed,the blood and liver samples were harvested.CHOP and Caspase-12 mRNA expression was detected using quantitative polymerase chain reaction.PKR-like ER kinase (PERK),P-eukaryotic translation initiation factor 2α (eIF2α),eIF2α,CHOP and caspase-12 expression was detected using western blotting (WB).CHOP and caspase-12 distribution and expression in liver tissues were determined using immunohistochemistry (IHC).Alanine aminotransferase and aspartate aminotransferase level were detected using an automatic biochemical analyzer.Hepatic cell apoptosis was detected using TUNEL.The results were analyzed using Quantity-one v4.62 software (Bio-Rad,USA).Results:CHOP and caspase-12 expression and PERK,eIF2α,and P-eIF2α protein expression showed no significant difference between BD group and DMSO group.Compared with BD group,Sal group had a significantly higher P-eIF2C level and a lower P-PERK level 2 h and 6 h after BD (P ＜ 0.05).However,eIF2α expression showed no significant difference (P ＞ 0.05).After the Sal treatment,CHOP and caspase-12 mRNA expression significantly decreased 4 h after BD (P ＜ 0.05).WB and IHC indicated that CHOP and caspase-12 expression also significantly decreased after Sal treatment.Sal was associated with improved liver function and decreased hepatic cell apoptosis.Conclusions:Sal can significantly reduce apoptosis in hepatic cells of BD rats

Shared Authentic Leadership in Research Teams: Testing a Multiple Mediation Model.

Science.gov (United States)

Guenter, Hannes; Gardner, William L; Davis McCauley, Kelly; Randolph-Seng, Brandon; Prabhu, Veena P

2017-12-01

Research teams face complex leadership and coordination challenges. We propose shared authentic leadership (SAL) as a timely approach to addressing these challenges. Drawing from authentic and functional leadership theories, we posit a multiple mediation model that suggests three mechanisms whereby SAL influences team effectiveness: shared mental models (SMM), team trust, and team coordination. To test our hypotheses, we collected survey data on leadership and teamwork within 142 research teams that recently published an article in a peer-reviewed management journal. The results indicate team coordination represents the primary mediating mechanism accounting for the relationship between SAL and research team effectiveness. While teams with high trust and SMM felt more successful and were more satisfied, they were less successful in publishing in high-impact journals. We also found the four SAL dimensions (i.e., self-awareness, relational transparency, balanced processing, and internalized moral perspective) to associate differently with team effectiveness.

Engineering international relations / Maris Riekstins ; interv. Talis Saule Archdeacon

Index Scriptorium Estoniae

Riekstins, Maris

2008-01-01

Läti annab peatselt Läänemeremaade Nõukogu eesistuja teatepulga üle Taanile. Läti välisminister Maris Riekstins Läänemeremaade Nõukogu teemadest ning suhetest Venemaaga. Maris Riekstins'i CV

Freak weather throws Balts into confusion / Talis Saule Archdeacon

Index Scriptorium Estoniae

Archdeacon, Talis Saule

2007-01-01

Erakordselt soe talv Baltimaades võib kahjustada suusakeskuste ja põllumajandusettevõtete majandustulemusi. Baltimaade võimalused EL-i uue kasvuhoonegaaside vähendamist nõudva keskkonnastrateegia täitmiseks

Presidents bid farewell to Vike-Freiberga / Talis Saule Archdeacon

Index Scriptorium Estoniae

Archdeacon, Talis Saule

2007-01-01

Eesti president Toomas Hendrik Ilves ja Leedu president Valdas Adamkus jätsid 3. juulil 2007 Riias hüvasti ametist lahkuva Läti presidendi Vaira Vike-Freibergaga. Baltimaade liidrid arutasid koostöö küsimusi

Union considers drastic action over wages / Talis Saule Archdeacon

Index Scriptorium Estoniae

Archdeacon, Talis Saule

2007-01-01

Läti ühinenud ametiühingud teatasid piketikavatsusest parlamendihoone ees 11. oktoobril, mil valitsus arutab järgmise aasta eelarvet. Ametiühingud nõuavad kõrgemat palka meditsiinitöötajatele ja õpetajatele

PACE president criticizes Baltics minority rights / Talis Saule Archdeacon

Index Scriptorium Estoniae

Archdeacon, Talis Saule

2007-01-01

Euroopa Nõukogu Parlamentaarse Assamblee president Rene van der Linden külastas Baltimaid ning kritiseeris vähemusrahvuste olukorda Eestis ja Lätis, tuues eeskujuks Leedut. Kriitikale vastavad Läti ja Eesti välisministrid

Controversial 2008 budget passed by Cabinet / Talis Saule Archdeacon

Index Scriptorium Estoniae

Archdeacon, Talis Saule

2007-01-01

Läti valitsus kiitis erakorralisel kohtumisel heaks 2008. aasta eelarve kava ja saatis selle parlamendile. Eelarvega rahulolematust on väljendanud ka koalitsioon ja rahvuspartei Isamaa ja Vabaduse Eest

Political battle drifts into pensioners' realm / Talis Saule Archdeacon

Index Scriptorium Estoniae

Archdeacon, Talis Saule

2008-01-01

Läti endised ministrid lõid poliitilise organisatsiooni, mis korraldab referendumi Läti madala vanaduspensioni tõstmise toetuseks. Samas valmistub ka valitsus pensionite tõstmiseks. Lisa: Faktid pensioni ja pensionäride kohta Lätis

Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13.

Science.gov (United States)

Xu, Wenxiao; Wan, Qiaoqiao; Na, Sungsoo; Yokota, Hiroki; Yan, Jing-Long; Hamamura, Kazunori

2015-12-01

Chondrosarcoma is the second frequent type of primary bone cancer. In response to stress to the endoplasmic reticulum, activation of eIF2α-mediated signaling is reported to induce apoptosis. However, its effects on invasive and migratory behaviors of chondrosarcoma have not been understood. Focusing on potential roles of Src kinase, Rac1 GTPase, and MMP13, we investigated eIF2α-driven regulation of SW1353 chondrosarcoma cells. In particular, we employed two chemical agents (salubrinal, Sal; and guanabenz, Gu) that elevate the level of eIF2α phosphorylation. The result revealed that both Sal and Gu reduced invasion and motility of SW1353 chondrosarcoma cells in a dose dependent manner. Live imaging using a fluorescent resonance energy transfer (FRET) technique showed that Sal and Gu downregulated activities of Src kinase as well as Rac1 GTPase in an eIF2α dependent manner. RNA interference experiments supported an eIF2α-mediated regulatory network in the inhibitory role of Sal and Gu. Partial silencing of MMP13 also suppressed malignant phenotypes of SW1353 chondrosarcoma cells. However, MMP13 was not regulated via eIF2α since administration of Sal but not Gu reduced expression of MMP13. In summary, we demonstrate that eIF2α dependent and independent pathways regulate invasion and motility of SW1353 chondrosarcoma cells, and inactivation of Src, Rac1, and MMP13 by Sal could provide a potential adjuvant therapy for combating metastatic chondrosarcoma cells. Copyright © 2015 Elsevier Inc. All rights reserved.

Y chromosomal and sex effects on the behavioral stress response in the defensive burying test in wild house mice

NARCIS (Netherlands)

Sluyter, F; Korte, SM; Van Baal, GCM; De Ruiter, AJH; Van Oortmerssen, GA

1999-01-01

Genetically selected short attack latency (SAL) and long attack latency (LAL) male wild house mice behave differently in the defensive burying test. When challenged, SAL males respond actively with more time spent on defensive burying, whereas LAL males are more passive with more time remaining

A history of semi-active laser dome and window materials

Science.gov (United States)

Sullivan, Roger M.

2014-05-01

Semi-Active Laser (SAL) guidance systems were developed starting in the mid-1960's and today form an important class of precision guided weapons. The laser wavelengths generally fall in the short wave infrared region of the spectrum. Relative to passive, image based, infrared seekers the optical demands placed on the domes or windows of SAL seekers is very modest, allowing the use of low cost, easily manufactured materials, such as polycarbonate. This paper will examine the transition of SAL window and dome science and technology from the laboratory to battlefield, with special emphasis on the story of polycarbonate domes.

Genetic analysis of patients with familial and sporadic amyotrophic lateral sclerosis in a Brazilian Research Center.

Science.gov (United States)

Chadi, Gerson; Maximino, Jessica Ruivo; Jorge, Frederico Mennucci de Haidar; Borba, Fabrício Castro de; Gilio, Joyce Meire; Callegaro, Dagoberto; Lopes, Camila Galvão; Santos, Samantha Nakamura Dos; Rebelo, Gabriela Natania Sales

2017-05-01

To investigate gene mutations in familial form (FALS) and sporadic form (SALS) of amyotrophic lateral sclerosis (ALS) in a highly miscegenated population. Frequencies of mutations in the C9orfF72, TARDBP, SOD1, FUS and VAPB genes were investigated in a cohort of FALS (n = 39) and SALS (n = 189) subjects from the Research Centre of the University of São Paulo School of Medicine. All patients were subjected to C9orf72 and TARDBP analyses. SOD1, FUS and VAPB were also evaluated in FALS subjects. Mutations were identified in FALS (61.3%) and SALS (5.3%) patients. Mutations in C9orf72 (12.8%, >45 GGGGCC hexanucleotide repeats), VAPB (43.6%, P56S) and SOD1 (7.7%, L145S) were identified in FALS subjects. Pathogenic C9orf72 expansions (2.64%) were identified in some SALS patients. Similar changes of TARDBP were found in SALS (2.64%) but not in FALS subjects. No FUS mutations were seen in any FALS subjects. TARDBP and C9orf72 mutations in this cohort were similar to those found in other centres worldwide. VAPB mutation (P56S) was highly prevalent in Brazilian FALS patients.

Sayısal Koruma Nedir?

OpenAIRE

Akbaytürk, Tuba

2008-01-01

The very first definition of preservation which comes to minds is ensuring the survival of information in valid forms for as long as it is wanted. The digital preservation, on the other hand focuses more on continued access to digital information. Three main strategies recommended in digital preservation are “Technology Preservation”, “Technology Emulation”, and “Information Migration”. Moreover, Digital Archeology techniques aiming the recovery of information are considered in this category....

I-III klasių mokinių kūrybingumo ugdymas taikant mokymo(si) bendradarbiaujant metodą

OpenAIRE

Gudžiūnienė, Nijolė; Ramaneckienė, Irena; Ptašinskienė, Irena

2003-01-01

One of the most important goals of teachers of primary forms is to develop pupils' communication competence and their creative skills. Co-operation method is especially useful striving for the segoals. The experiment has lasted for three years, and 26 pupils from Šiauliai town Saule primary school took part in it. During the study the effect of co-operation method on pupils' cognitive skills and communication competence was established and its influence on pupils' ability to create fairy-tale...

Effective Client Management: Maximizing The Influence of External Sponsors Over Affiliated Armed Groups

Science.gov (United States)

2017-12-01

David and his men with sanctuary— thinking them to be allies against Saul.9 However, David was deceiving Achish about his attacks against Israel, and...main objectives with this strategy. First, it was hedging its bets —any faction that gained political power would have some type of relationship with... think -16291. 397 Garrison, “Disaggregating the ‘Axis of Resistance,’” 67; Ali, “ISW Blog.” 398 Mansour, “From Militia to State Force.” 399 Jean

Antigenic profile of human recombinant PrP: generation and chracterization of a versatile polyclonal antiserum

NARCIS (Netherlands)

Sachsamanoglou, M.; Paspaltzis, I.; Petrakis, S.; Verghese-Nikolakaki, S.; Panagiotidis, C.H.; Voitlander, T.; Budka, H.; Langeveld, J.P.M.; Sklaviadis, T.

2004-01-01

We describe the quality of a rabbit polyclonal antiserum (Sal1) that was raised against mature human recombinant prion protein (rhuPrP). Epitope mapping demonstrated that the Sal1 antiserum recognized six to eight linear antigenic sites, depending on the animal species. The versatility of the

Polymer Surface Engineering for Efficient Printing of Highly Conductive Metal Nanoparticle Inks.

Science.gov (United States)

Agina, Elena V; Sizov, Alexey S; Yablokov, Mikhail Yu; Borshchev, Oleg V; Bessonov, Alexander A; Kirikova, Marina N; Bailey, Marc J A; Ponomarenko, Sergei A

2015-06-10

An approach to polymer surface modification using self-assembled layers (SALs) of functional alkoxysilanes has been developed in order to improve the printability of silver nanoparticle inks and enhance adhesion between the metal conducting layer and the flexible polymer substrate. The SALs have been fully characterized by AFM, XPS, and WCA, and the resulting printability, adhesion, and electrical conductivity of the screen-printed metal contacts have been estimated by cross-cut tape test and 4-point probe measurements. It was shown that (3-mercaptopropyl)trimethoxysilane SALs enable significant adhesion improvements for both aqueous- and organic-based silver inks, approaching nearly 100% for PEN and PDMS substrates while exhibiting relatively low sheet resistance up to 0.1 Ω/sq. It was demonstrated that SALs containing functional -SH or -NH2 end groups offer the opportunity to increase the affinity of the polymer substrates to silver inks and thus to achieve efficient patterning of highly conductive structures on flexible and stretchable substrates.

Glucose administration after traumatic brain injury exerts some benefits and no adverse effects on behavioral and histological outcomes.

Science.gov (United States)

Shijo, Katsunori; Ghavim, Sima; Harris, Neil G; Hovda, David A; Sutton, Richard L

2015-07-21

The impact of hyperglycemia after traumatic brain injury (TBI), and even the administration of glucose-containing solutions to head injured patients, remains controversial. In the current study adult male Sprague-Dawley rats were tested on behavioral tasks and then underwent surgery to induce sham injury or unilateral controlled cortical impact (CCI) injury followed by injections (i.p.) with either a 50% glucose solution (Glc; 2g/kg) or an equivalent volume of either 0.9% or 8% saline (Sal) at 0, 1, 3 and 6h post-injury. The type of saline treatment did not significantly affect any outcome measures, so these data were combined. Rats with CCI had significant deficits in beam-walking traversal time and rating scores (p's beam-walking deficits were not affected by Glc versus Sal treatments. Persistent post-CCI deficits in forelimb contraflexion scores and forelimb tactile placing ability were also not differentially affected by Glc or Sal treatments. However, deficits in latency to retract the right hind limb after limb extension were significantly attenuated in the CCI-Glc group (p < 0.05 versus CCI-Sal). Both CCI groups were significantly impaired in a plus maze test of spatial working memory on days 4, 9 and 14 post-surgery (p < 0.001 versus sham), and there was no effect of Glc versus Sal on this cognitive outcome measure. At 15 days post-surgery the loss of cortical tissue volume (p < 0.001 versus sham) was significantly less in the CCI-Glc group (30.0%; p < 0.05) compared to the CCI-Sal group (35.7%). Counts of surviving hippocampal hilar neurons revealed a significant (~40%) loss ipsilateral to CCI (p < 0.001 versus sham), but neuronal loss in the hippocampus was not different in the CCI-Sal and CCI-Glc groups. Taken together, these results indicate that an early elevation of blood glucose may improve some neurological outcomes and, importantly, the induction of hyperglycemia after isolated TBI did not adversely affect any sensorimotor, cognitive or

INFLUÊNCIA DO POTENCIAL ANTIOXIDANTE DE EXTRATO DE ERVA-MATE (Ilex paraguariensis St. Hil EM FRANGO ASSADO, ARMAZENADO E REAQUECIDO

Directory of Open Access Journals (Sweden)

Marineusa CAMEL

2012-04-01

Full Text Available O objetivo deste trabalho foi avaliar o potencial antioxidante do extrato de erva-mate (Ilex paraguariensis em carne de frango. As sobrecoxas de frango foram submetidas a diferentes tratamentos (sem condimentos; com sal, sal e sálvia, sal, sálvia e extrato (0,125%; sal e extrato (0,125%, sal, sálvia e extrato (0,25% e sal e extrato (0,25% e analisadas na forma crua, assada, após armazenamento sob refrigeração e após reaquecimento. A atividade antioxidante in vitro do extrato foi determinada pelo teste de DPPH (difenilpicrilhidrazina. As amostras dos diferentes tratamentos foram submetidas às análises de oxidação de lipídios (TBARS, pH, potencial de oxiredução (mV, cor objetiva (L, a, b e análise sensorial. O teste DPPH mostrou correlação entre a atividade antioxidante (% e concentração de extrato fornecendo IC50 de 255μg/mL. Em relação à oxidação de lipídios, as amostras sem condimentos e somente com adição de sal diferiram das demais (p<0,05 quando armazenadas e após reaquecimento. A amostra com 0,125% de extrato de erva-mate diferiu das amostras contendo 0,25% de extrato na condição armazenado, mostrando o efeito do aumento da concentração de extrato contra a oxidação lipídica das sobrecoxas. Não houve diferença significativa entre os diferentes tratamentos e condições em relação ao pH e potencial de oxi-redução. A adição dos extratos alterou significativamente (p<0,05 a cor b nas amostras reaquecidas e a cor L nas amostras armazenadas e reaquecidas. Os atributos sensoriais de aceitação geral dos diferentes tratamentos não apresentaram diferença significativa entre as amostras testadas.

Estudo de validação das equações de Tanaka e de Kawasaki para estimar a excreção diária de sódio através da coleta da urina casual

Directory of Open Access Journals (Sweden)

José Geraldo Mill

2015-12-01

Full Text Available RESUMO: Objetivo: Validar as fórmulas de Tanaka e Kawasaki para cálculo do consumo de sal pela relação sódio/creatinina na urina casual. Métodos: Foram estudados 272 adultos (20 - 69 anos, 52,6% de mulheres com coleta urinária de 24 h e duas coletas casuais no mesmo dia (em jejum - casual 1 - e fora do jejum - casual 2. Antropometria, pressão arterial e coleta de sangue foram obtidos no mesmo dia. A concordância entre o consumo de sal estimado pela urina de 24 h e pela urina casual foi feita por Pearson (r e Bland & Altman. Resultados: O consumo médio de sal medido pela urina de 24 h foi de 10,4 ± 5,3 g/dia. A correlação entre a excreção de sódio na urina de 24 h e a estimada pela urina casual 1 ou 2, respectivamente, foi apenas moderada, tanto por Tanaka (r = 0,51 e r = 0,55; p < 0,001 como por Kawasaki (r = 0,52 e r = 0,54; p < 0,001. Observa-se subestimação crescente dos valores estimados em relação ao medido com o aumento do consumo de sal pela fórmula de Tanaka e, ao contrário, superestimação ao usar a fórmula de Kawasaki. As fórmulas estimam adequadamente o consumo diário de sal (diferença entre sal medido e estimado de, no máximo, 1 g/dia somente com consumo entre 9 - 12 g/dia (Tanaka e 12 - 18 g/dia (Kawasaki. Conclusão: A coleta de urina casual estima adequadamente o consumo de sal apenas nos indivíduos próximos à média populacional.

Variaciones temporales del fitoplancton de los ríos tributarios y emisario del embalse C. Gelsi (Tucumán, Argentina

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Silvia N Martinez de Marco

2012-12-01

Full Text Available En este trabajo se estudiaron las variaciones temporales del fitoplancton de los tributarios (ríos Salí, Tapia y Vipos y del emisario (río Salí del embalse C. Gelsi. La abundancia algal mínima se obtuvo en verano con una biomasa de 0,19-0,58 µg Cl-a L-1 y la máxima en invierno o primavera con una biomasa de 5,43-6,79 µg Cl-a L-1. En los tributarios se destacaron las diatomeas pennadas sobresaliendo Diatoma vulgare y Cymbella affinis y en el río Salí (emisario dominaron las céntricas especialmente Aulacoseira granulata y Cyclotella meneghiniana. Las Chlorophyta se ubicaron en segundo término en el río Salí, las Cyanobacteria codominaron en los ríos Vipos y Tapia en marzo de 1998 y las Dinophyta sólo fueron observadas en el Salí (emisario. El índice de diversidad específica osciló entre 0,2 y 4,2 y el sapróbico caracterizó las aguas como "no poluídas" o "ligeramente poluídas" en invierno y como "moderadamente poluídas" en verano. El NMDS ordenó temporalmente las muestras según la abundancia de las especies algales consideradas. Los dos primeros ejes del RDA separaron los sitios según gradientes de temperatura, pH, conductividad, DBO5 y nitrato, además de la abundancia de Aulacoseira granulata, Cyclotella meneghiniana, Ulnaria ulna, Cymbella affinis y Leptolyngbya foveolarum.Temporal variations of the phytoplankton of the tributaries and effluent from the C. Gelsi reservoir (Tucumán, Argentina. In this paper we analyzed the phytoplankton variation in the tributaries (Salí, Tapia, and Vipos rivers and effluent (Salí River from the C. Gelsi reservoir according to a seasonal gradient. The minimum algal abundance took place in summer with a biomass of 0.19-0.58 µg Cl-a L-1, while the maximum occurred in winter or in spring, with a biomass of 5.43-6.79 µg Cl-a L-1. In the tributaries pennate diatoms prevailed, Diatoma vulgare and Cymbella affinis were most abundant, while in the Salí river (Gelsi effluent centric

An IR Sounding-Based Analysis of the Saharan Air Layer in North Africa

Science.gov (United States)

Nicholls, Stephen D.; Mohr, Karen I.

2018-01-01

Intense daytime surface heating over barren-to-sparsely vegetated surfaces results in dry convective mixing. In the absence of external forcing such as mountain waves, the dry convection can produce a deep, well-mixed, nearly isentropic boundary layer that becomes a well-mixed residual layer in the evening. These well-mixed layers (WML) retain their unique mid-tropospheric thermal and humidity structure for several days. To detect the SAL and characterize its properties, AIRS Level 2 Ver. 6 temperature and humidity products (2003-Present) are evaluated against rawinsondes and compared to model analysis at each of the 55 rawinsonde stations in northern Africa. To distinguish WML from Saharan air layers (WMLs of Saharan origin), the detection involved a two-step process: 1) algorithm-based detection of WMLs in dry environments (less than 7 g per kilogram mixing ratio) 2) identification of Sahara air layers (SAL) by applying Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) back trajectories to determine the history of each WML. WML occurrence rates from AIRS closely resemble that from rawinsondes, yet rates from model analysis were up to 30% higher than observations in the Sahara due to model errors. Despite the overly frequent occurrence of WMLs from model analysis, HYSPLIT trajectory analysis showed that SAL occurrence rates (given a WML exists) from rawinsondes, AIRS, and model analysis were nearly identical. Although the number of WMLs varied among the data sources, the proportion of WMLs which were classified as SAL was nearly the same. The analysis of SAL bulk properties showed that AIRS and model analysis exhibited a slight warm and moist bias relative to rawinsondes in non-Saharan locations, but model analysis was notably warmer than rawinsondes and AIRS within the Sahara. The latter result is likely associated with the dearth of available data assimilated by model analysis in the Sahara. The variability of SAL thicknesses was reasonably

AÇÃO ANTILISTERIAL DO EXTRATO BRUTO DE Bacillus Amyloliquefaciens EM DIFERENTES CONCENTRAÇÕES DE PROTEÍNA, pH E SAL

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M. A. PEREIRA

2008-09-01

Full Text Available

O elevado índice de morbidade em função da contaminação dos alimentos tem aumentado a necessidade de metodologias alternativas para conservação dos mesmos. Nesse sentido, essa pesquisa teve por objetivo: (1 otimizar a ação antilisterial do extrato bruto produzido por Bacillus amyloliquefaciens em diferentes concentrações proteicas, pH e sal; (2 avaliar a ação do extrato bruto otimizado em ostras artificialmente contaminadas com Listeria monocytogenes. A ação do extrato bruto em diferentes concentrações de proteína (0,0; 5,0; 40; 80 µg/mL sobre o inóculo de 10⁶ UFC.mL^-1 de Listeria monocytogenes foi verificada em caldo TSB-YE previamente ajustado para pH 4,0 e 8,0 e concentrações de NaCl de 0; 2,5 e 4,5 % p/v. Os ensaios foram realizados à temperatura de 25ºC em estufa DBO. Para determinar a recuperação microbiana, realizaram-se contagens de Listeria monocytogenes a cada 4 h, por até 50 h. Dos tratamentos testados, a combinação de 80 g/mL de proteína do extrato bruto, pH 4,0 e 4,5 % de NaCl mostrou melhor performance quanto a atividade antimicrobiana, chegando a uma redução de até 5 ciclos logarítmicos de Listeria monocytogenes. Quando testada a ação do tratamento conjunto de 80 g/mL de extrato bruto, pH 4,0 e 4,5 % de NaCl sobre carne de ostra, obteve-se uma redução no número de Listeria monocytogenes de aproximadamente 3 ciclos logarítmicos, (3,0x10⁶ para 1,5x10³ UFC.mL^-1, após 24 h de incubação a 25ºC. Esses resultados indicam a possível utilização do antimicrobiano produzido por Bacillus amyloliquefaciens como conservador de alimentos.

Future Time Orientation and Learning Conceptions: Effects on Metacognitive Strategies, Self-Efficacy Beliefs, Study Effort and Academic Achievement

Science.gov (United States)

Gutiérrez-Braojos, Calixto

2015-01-01

During the past decade, research on the constructive learning process has been conducted mainly from two perspectives: student approaches to learning (SAL) and self-regulated learning (SRL). The SAL perspective has highlighted the role of learning conceptions with respect to other topics involved in constructive learning processes, whereas…

Die Gereformeerde Ekumeniese Sinode en Sending 1984

African Journals Online (AJOL)

opvatting. Indien 'n mens al die kerke wat aan die Gereformeerde. Ekumeniese Sinode (GES) behoort een vir een sendingmatig sal be- studeer, sal daar waarskynlik 'n sterk differensiasie tussen sommige kerke aan die lig kom. Die GES kan dus nie verantwoordelik gehou word vir individuele kerke se sendingopvatting nie.

Tegn. Red.

African Journals Online (AJOL)

rbr

gawe uit meer as twee maal soveel lemmas sal bestaan. Selfs tien duisend lem- mas sal geensins 'n volledige versameling "etimologiseerbare" Afrikaanse lemmas verteenwoordig nie, en dit is goed dat EWA geensins makrostruktu- rele volledigheid op die agenda het nie. Nogtans, hoewel daar in hierdie stadium niks oor ...

Virulence Characterization of Salmonella enterica by a New Microarray: Detection and Evaluation of the Cytolethal Distending Toxin Gene Activity in the Unusual Host S. Typhimurium.

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Rui Figueiredo

Full Text Available Salmonella enterica is a zoonotic foodborne pathogen that causes acute gastroenteritis in humans. We assessed the virulence potential of one-hundred and six Salmonella strains isolated from food animals and products. A high through-put virulence genes microarray demonstrated Salmonella Pathogenicity Islands (SPI and adherence genes were highly conserved, while prophages and virulence plasmid genes were variably present. Isolates were grouped by serotype, and virulence plasmids separated S. Typhimurium in two clusters. Atypical microarray results lead to whole genome sequencing (WGS of S. Infantis Sal147, which identified deletion of thirty-eight SPI-1 genes. Sal147 was unable to invade HeLa cells and showed reduced mortality in Galleria mellonella infection model, in comparison to a SPI-1 harbouring S. Infantis. Microarray and WGS of S. Typhimurium Sal199, established for the first time in S. Typhimurium presence of cdtB and other Typhi-related genes. Characterization of Sal199 showed cdtB genes were upstream of transposase IS911, and co-expressed with other Typhi-related genes. Cell cycle arrest, cytoplasmic distension, and nuclear enlargement were detected in HeLa cells infected by Sal199, but not with S. Typhimurium LT2. Increased mortality of Galleria was detected on infection with Sal199 compared to LT2. Thus, Salmonella isolates were rapidly characterized using a high through-put microarray; helping to identify unusual virulence features which were corroborated by further characterisation. This work demonstrates that the use of suitable screening methods for Salmonella virulence can help assess the potential risk associated with certain Salmonella to humans. Incorporation of such methodology into surveillance could help reduce the risk of emergence of epidemic Salmonella strains.

Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice.

Science.gov (United States)

Chien, Mei-Yin; Chuang, Cheng-Hung; Chern, Chang-Ming; Liou, Kou-Tong; Liu, Der-Zen; Hou, Yu-Chang; Shen, Yuh-Chiang

2016-10-01

Salvianolic acid A (SalA), a chemical type of caffeic acid trimer, has drawn great attention for its potent bioactivities against ischemia-induced injury both in vitro and in vivo. In this study, we evaluated SalA's protective effects against acute ischemic stroke by inducing middle cerebral artery occlusion/reperfusion (MCAO) injuries in mice. Treatment of the mice with SalA (50 and 100μg/kg, i.v.) at 2h after MCAO enhanced their survival rate, improved their moving activity, and ameliorated the severity of brain infarction and apoptosis seen in the mice by diminishing pathological changes such as the extensive breakdown of the blood-brain barrier (BBB), nitrosative stress, and the activation of an inflammatory transcriptional factor p65 nuclear factor-kappa B (NF-κB) and a pro-apoptotic kinase p25/Cdk5. SalA also intensively limited cortical infarction and promoted the expression of neurogenesis protein near the peri-infarct cortex and subgranular zone of the hippocampal dentate gyrus by compromising the activation of GSK3β and p25/Cdk5, which in turn upregulated β-catenin, doublecortin (DCX), and Bcl-2, most possibly through the activation of PI3K/Akt signaling via the upregulation of brain-derived neurotrophic factor. We conclude that SalA blocks inflammatory responses by impairing NF-κB signaling, thereby limiting inflammation/nitrosative stress and preserving the integrity of the BBB; SalA also concomitantly promotes neurogenesis-related protein expression by compromising GSK3β/Cdk5 activity to enhance the expression levels of β-catenin/DCX and Bcl-2 for neuroprotection. Copyright © 2016 Elsevier Inc. All rights reserved.

An alternative option for "resect and discard" strategy, using magnifying narrow-band imaging: a prospective "proof-of-principle" study.

Science.gov (United States)

Takeuchi, Yoji; Hanafusa, Masao; Kanzaki, Hiromitsu; Ohta, Takashi; Hanaoka, Noboru; Yamamoto, Sachiko; Higashino, Koji; Tomita, Yasuhiko; Uedo, Noriya; Ishihara, Ryu; Iishi, Hiroyasu

2015-10-01

The "resect and discard" strategy is beneficial for cost savings on screening and surveillance colonoscopy, but it has the risk to discard lesions with advanced histology or small invasive cancer (small advanced lesion; SALs). The aim of this study was to prove the principle of new "resect and discard" strategy with consideration for SALs using magnifying narrow-band imaging (M-NBI). Patients undergoing colonoscopy at a tertiary center were involved in this prospective trial. For each detected polyp <10 mm, optical diagnosis (OD) and virtual management ("leave in situ", "discard" or "send for pathology") were independently made using non-magnifying NBI (N-NBI) and M-NBI, and next surveillance interval were predicted. Histological and optical diagnosis results of all polyps were compared. While the management could be decided in 82% of polyps smaller than 10 mm, 24/31 (77%) SALs including two small invasive cancers were not discarded based on OD using M-NBI. The sensitivity [90% confidence interval (CI)] of M-NBI for SALs was 0.77 (0.61-0.89). The risk for discarding SALs using N-NBI was significantly higher than that using M-NBI (53 vs. 23%, p = 0.02). The diagnostic accuracy (95% CI) of M-NBI in distinguishing neoplastic from non-neoplastic lesions [0.88 (0.86-0.90)] was significantly better than that of N-NBI [0.84 (0.82-0.87)] (p = 0.005). The results of our study indicated that our "resect and discard" strategy using M-NBI could work to reduce the risk for discarding SALs including small invasive cancer (UMIN-CTR, UMIN000003740).

An 40 Ar- 39 Ar study of the Cape Verde hot spot

DEFF Research Database (Denmark)

Holm, Paul Martin; Grandvuinet, Tanja; Wilson, James Richard

2008-01-01

The 40Ar-39Ar analyses of 28 groundmass separates from volcanic rocks from the islands of Santiago, Sal, and São Vicente, Cape Verde archipelago, are presented. The new age data record the volcanic evolution for Santiago from 4.6 to 0.7 Ma, for Sal from around 15 to 1.1 Ma, and for São Vicente from...... Cretaceous age for limestones deposited on the seafloor and later uplifted. The Cape Verde Rise is indicated to have fully formed in the early Miocene around 22 Ma, accompanied by the initial alkaline volcanism. Considerable volcanism on Sal, Boa Vista, and Maio took place in the Miocene and Pliocene...

Specified assurance level sampling procedure

International Nuclear Information System (INIS)

Willner, O.

1980-11-01

In the nuclear industry design specifications for certain quality characteristics require that the final product be inspected by a sampling plan which can demonstrate product conformance to stated assurance levels. The Specified Assurance Level (SAL) Sampling Procedure has been developed to permit the direct selection of attribute sampling plans which can meet commonly used assurance levels. The SAL procedure contains sampling plans which yield the minimum sample size at stated assurance levels. The SAL procedure also provides sampling plans with acceptance numbers ranging from 0 to 10, thus, making available to the user a wide choice of plans all designed to comply with a stated assurance level

Salmeterol/fluticasone stable-dose treatment compared with formoterol/budesonide adjustable maintenance dosing: impact on health-related quality of life

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Williams Angela E

2007-07-01

Full Text Available Abstract Background Improving patients' health-related quality of life (HRQoL is recognized as a fundamental part of asthma management. The aims of this study were to evaluate the long-term efficacy (including symptom-free days and exacerbations and impact on HRQoL of a stable-dose regimen of salmeterol/fluticasone propionate (SAL/FP and an adjustable maintenance dosing (AMD regimen of formoterol/budesonide (FOR/BUD where treatment is adjusted based on symptoms [SAM40056]. Methods A total of 688 outpatients with asthma receiving regular low-dose inhaled corticosteroids (ICS plus a long-acting β2-agonist, or medium dose ICS alone participated in this randomized, double-blind, double-dummy, parallel-group, 1-year trial, which was conducted in 91 centers in 15 countries. Patients were randomized to receive 1 inhalation of SAL/FP 50/250 μg BID or 2 inhalations of FOR/BUD 6/200 μg BID during Weeks 1–4. For Weeks 5–52, patients meeting strict continuation criteria for stable asthma at Week 4 received AMD with FOR/BUD or stable-dose SAL/FP. Results The percentage of symptom-free days was significantly greater (58.8% vs 52.1%; p = 0.034 and the annual exacerbation rate was significantly lower (47%; p = 0.008 with stable-dose SAL/FP compared with FOR/BUD AMD. A total of 568 patients completed the Asthma Quality of Life Questionnaire (AQLQ at least once during the study. The mean change from baseline in AQLQ overall score was numerically greater with SAL/FP than FOR/BUD at week 28 and week 52, but did not reach statistical significance (p = 0.121 at Week 52. However, in a post hoc logistic regression analyses for any AQLQ improvement, significant benefits with SAL/FP were seen at both time points (p = 0.038 and p = 0.009, respectively. The minimally important difference of ≥ 0.5-point improvement in AQLQ overall score was achieved by a significantly greater number of patients receiving SAL/FP at Week 28 (68% vs 60%; p = 0.049; a trend for this

Salário mínimo, benefício previdenciário e as famílias de baixa renda Minimum wage, social security benefits and low-income families

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Cláudio Salvadori Dedecca

2006-12-01

Full Text Available Este artigo tem foco nas famílias com rendimento per capita de até ¼ do salário mínimo. São analisadas as condições de inserção no mercado de trabalho e a influência dos benefícios previdenciários para o padrão de renda auferido. A preocupação, portanto, volta-se para a importância dos benefícios da previdência, no sentido de atenuar a fragilidade de renda destas famílias e as conseqüências da desvinculação do valor do seu piso do salário mínimo para este padrão de rendimentos. Analisando-se as características dos componentes das famílias de baixa renda, observa-se que, diante das transformações estruturais no processo de produção e do cenário conjuntural da economia brasileira, aqueles com idade ativa não apresentam os pré-requisitos necessários para se inserirem de forma digna no mundo do trabalho. Dessa forma, o estudo da composição da renda das famílias mais pobres mostra que a renda dos inativos - aposentados e pensionistas - é fundamental para retirar tais famílias do limite da linha de pobreza. O perfil dos componentes das famílias será analisado a partir dos microdados da Pesquisa Nacional por Amostra de Domicílios - PNAD/IBGE - para 2004, segundo idade, nível de escolaridade, cor ou raça e inserção no mercado de trabalho propriamente dita: tipo de atividade exercida e posição na ocupação. A comparação do perfil dos componentes das famílias mais carentes com o do total das famílias mostrará que as rendas de aposentadoria e pensão tornam-se fundamentais não apenas para diminuição da desigualdade, mas, fundamentalmente, para redução da pobreza.This article discusses families with per capita income of up to ¼ of the minimum monthly wage in Brazil. The conditions of participation in the labor market and the influence of social security benefits on the pattern of income earned are analyzed. The concern, therefore, is with the importance of social security benefits in attenuating

Investigation on a Sensitive Chemiluminescence System Based on Ni(IV Complex to Determine Two β2-Agonist Drugs in Urine and Swine Feed and Their Mechanism

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Xiao Dong

2018-04-01

Full Text Available Veterinary drug residues, particularly traces of β2-agonists, can cause various kinds of harmful impact to the environment and public health. Here, a sensitive chemiluminescence (CL method incorporated with a flow injection analysis is developed for the determination of two β2-agonists [i.e., salbutamol (SAL and terbutaline (TEB]. The system is based on the CL reaction of Ni(IV complex with luminol in alkaline solutions, whereas SAL and TEB can significantly enhance CL intensities. Under optimum conditions, CL intensities are proportional to the SAL and TEB concentration in the range of 1.0 × 10−9 M to 5.0 × 10−7 M and 1.0 × 10−9 M to 1.0 × 10−7 M, respectively. The limits of detection (3σ are 1.0 × 10−11 M for TEB, and 1.3 × 10−11 for SAL respectively. Relative standard deviations (n = 11 are less than 2% for 5.0 × 10−8 M SAL and TEB. Possible reaction mechanisms for the CL system are suggested based on the CL system spectra, Ni(IV complex oxidation characteristics, and electron spin resonance (ESR techniques. The proposed method has been applied to the analysis of urine and swine feed samples with satisfactory results.

Study of the HFE gene common polymorphisms in French patients with sporadic amyotrophic lateral sclerosis.

Science.gov (United States)

Praline, Julien; Blasco, Hélène; Vourc'h, Patrick; Rat, Valérian; Gendrot, Chantal; Camu, William; Andres, Christian R

2012-06-15

Our objective was to investigate whether the C282Y (p.Cys 282 Tyr) and H63D (p. His 63 Asp) HFE polymorphisms were associated with sporadic amyotrophic lateral sclerosis (SALS) in the French population. We searched for a relation of HFE polymorphisms with the clinical characteristics of the disease. The HFE polymorphisms were studied in 824 patients with SALS and 583 controls. We compared the frequency of the polymorphisms between SALS and controls groups by univariate and multivariate statistics, taking into account gender, site, age-at-onset and survival. We did not observe significant difference in the frequency of H63D polymorphism between SALS and control group. We observed a significant difference for C282Y between patients and controls with a low frequency of the Y allele in patients (3.2%) compared to our control group (5.9%). Disease duration, distribution of gender, site-of-onset, age-at-onset did not differ between groups taking into account genotypes of each polymorphism. Our results in this large cohort of ALS patients indicate that H63D polymorphism is not associated with SALS in the French population. This conclusion does not exclude a weak effect of the HFE gene polymorphisms in certain ALS populations, or an effect of other rare HFE gene variants. Copyright © 2012 Elsevier B.V. All rights reserved.

The contribution of formal genetic studies to the characterization of the Mediterranean fruit fly, Ceratitis capitata (Wied.)

International Nuclear Information System (INIS)

Malacrida, A.R.; Gasperi, G.; Baruffi, L.; Milani, R.

1990-01-01

Twenty-eight functional loci and four morphological gene markers have been assigned to five of the six linkage groups of the Mediterranean fruit fly (medfly), Ceratitis capitata (Wiedemann). The linkage group labelling system, proposed by Saul and Roessler, has been adopted. Map distances, obtained for twenty markers, showed the marked loci to be distributed over wide map intervals in all five autosomal linkage groups. The available information appears adequate for determining the position of chromosomal characteristics peculiar to each chromosome. (author). 14 refs, 2 tabs

Linlane ei tea, kuidas maal elatakse / Imbi Raikna

Index Scriptorium Estoniae

Raikna, Imbi

2004-01-01

2004. a. märtsis ja aprillis tehtud uurimusest "Põllumajandusministeeriumi ja maaelu imago Eesti linnaelanike seas". Tabelid: Maakohtade külastamise sagedus; Maakohtade külastamise põhjused. Vt. ka: Mida maaelu tundjad arvavad linnaelanike uuringu tulemustest. Kommenteerivad Riigikogu liikmed Imre Sooäär, Jaanus Marrandi ja Mati Kepp, MTÜ Saaremaa Kodukant juht Elvi Viira, MTÜ Kodukant Viljandimaa juht Kaja Kaur, MTÜ Kodukant Tartumaa juht Lea Saul, Saarde vallavalitsuse volikogu esimees Väino Lill ja Lääne-Virumaa Uhtna küla elanik Inge Pikkoja

Is Apartheid ook op ekonomiese grond geregverdig?

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B. van Deventer

1956-03-01

Full Text Available Die mening word vandag dikwels uitgespreek (ook deur Nasionaliste dat apartheid nie op ekonomiese gronde geregverdig kan word nie; of anders gestel, dat apartheid van die blankes te groot offers sal verg; of nog sterker gestel, dat die blankes op ekonomiese gebied nie sonder die naturel sal kan klaarkom nie.

Synthesis of Nano-Zinc Oxide Loaded on Mesoporous Silica by Coordination Effect and Its Photocatalytic Degradation Property of Methyl Orange.

Science.gov (United States)

Shen, Zhichuan; Zhou, Hongjun; Chen, Huayao; Xu, Hua; Feng, Chunhua; Zhou, Xinhua

2018-05-09

Salicylaldimine-modified mesoporous silica (Sal-MCM-3 and Sal-MCM-9) was prepared through a co-condensation method with different amounts of added salicylaldimine. With the coordination from the salicylaldimine, zinc ions were impregnated on Sal-MCM-3 and Sal-MCM-9. Then, Zn-Sal-MCM-3 and Zn-Sal-MCM-9 were calcined to obtain nano-zinc oxide loaded on mesoporous silica (ZnO-MCM-3 and ZnO-MCM-9). The material structures were systematically studied by Fourier transform infrared spectroscopy (FTIR), N₂ adsorption/desorption measurements, X-ray powder diffraction (XRD), zeta potential, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), ultraviolet diffused reflectance spectrum (UV-vis DRS), and thermogravimetry (TGA). Methyl orange (MO) was used to investigate the photocatalysis behavior of ZnO-MCM-3 and ZnO-MCM-9. The results confirmed that nano ZnO was loaded in the channels as well as the outside surface of mesoporous silica (MCM-41). The modification of salicylaldimine helped MCM-41 to load more nano ZnO on MCM-41. When the modification amount of salicylaldimine was one-ninth and one-third of the mass of the silicon source, respectively, the load of nano ZnO on ZnO-MCM-9 and ZnO-MCM-3 had atomic concentrations of 1.27 and 2.03, respectively. ZnO loaded on ZnO-MCM-9 had a wurtzite structure, while ZnO loaded on ZnO-MCM-3 was not in the same crystalline group. The blocking effect caused by nano ZnO in the channels reduced the orderliness of MCM-41. The photodegradation of MO can be divided in two processes, which are mainly controlled by the surface areas of ZnO-MCM and the loading amount of nano ZnO, respectively. The pseudo-first-order model was more suitable for the photodegradation process.

Salvianolic acid B: In vitro and in vivo effects on the immune system

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Vujičić Milica

2017-01-01

Full Text Available Type 1 diabetes (T1D is an autoimmune disorder with a strong inflammatory component. Autoreactive cells specifically target insulin-producing β-cells, which leads to loss of glucose homeostasis. T1D remains incurable and versatile; potentially beneficial therapeutics are being tested worldwide. Possible candidates for the treatment of autoimmune diabetes are plants and their extracts since they are rich in biophenols, substances that act as secondary metabolites, and have verified antioxidant and antiinflammatory effects. Salvianolic acid B (SalB is a biophenol and one of the major constituents of Origanum vulgare ssp. hirtum (Greek oregano extracts which in our previous studies was shown to exhibit an antidiabetic effect in mice. The aim of the present study was to determine whether SalB is responsible for the observed effects of Greek oregano extracts. SalB was applied in vitro to macrophages and lymphocytes isolated from C57BL/6 mice, as well as in vivo in the model of T1D induced by multiple low doses (MLD of streptozotocin (STZ. SalB did not affect the viability of cells, but it significantly decreased secretion of nitric oxide (NO and TNF in lipopolysaccharide (LPS-stimulated macrophages, as well as the secretion of IFN-γ in concanavalin A (ConA-stimulated lymphocytes. However, when applied in vivo, SalB at a dose of 2.5 mg/kg b.w., applied for 10 consecutive days, failed to protect mice from diabetes development. In conclusion, SalB exerts immunomodulatory effects in vitro, but is not effective in prevention of T1D in vivo. It probably requires cooperation with some other substances for the maximum efficacy exhibited by oregano extracts. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. OI 173013

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis.

Science.gov (United States)

Italiani, Paola; Carlesi, Cecilia; Giungato, Paola; Puxeddu, Ilaria; Borroni, Barbara; Bossù, Paola; Migliorini, Paola; Siciliano, Gabriele; Boraschi, Diana

2014-05-23

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease leading to the death of affected individuals within years. The involvement of inflammation in the pathogenesis of neurodegenerative diseases, including ALS, is increasingly recognized but still not well understood. The aim of this study is to evaluate the levels of inflammation-related IL-1 family cytokines (IL-1β, IL-18, IL-33, IL-37) and their endogenous inhibitors (IL-1Ra, sIL-1R2, IL-18BP, sIL-1R4) in patients with sporadic ALS (sALS), METHODS: Sera were collected from 144 patients (125 patients were characterized by disease form, duration, and disability, using the revised ALS functional rating scale (ALSFRS-R) and from 40 matched controls. Cerebrospinal fluid (CSF) was collected from 54 patients with sALS and 65 patients with other non-infectious non-oncogenic diseases as controls. Cytokines and inhibitors were measured by commercial ELISA. Among the IL-1 family cytokines tested total IL-18, its endogenous inhibitor IL-18BP, and the active form of the cytokine (free IL-18) were significantly higher in the sALS sera than in controls. No correlation between these soluble mediators and different clinical forms of sALS or the clinical setting of the disease was found. IL-18BP was the only mediator detectable in the CSF of patients. Among the IL-1 family cytokines, only IL-18 correlates with this disease and may therefore have a pathological role in sALS. The increase of total IL-18 suggests the activation of IL-18-cleaving inflammasome. Whether IL-18 upregulation in circulation of sALS patients is a consequence of inflammation or one of the causes of the pathology still needs to be addressed.

Effects of Systane(®) Balance on noninvasive tear film break-up time in patients with lipid-deficient dry eye.

Science.gov (United States)

Aguilar, Alejandro J; Marquez, Maria I; Albera, Paula A; Tredicce, Jorge L; Berra, Alejandro

2014-01-01

To evaluate the ability of Systane(®) Balance (SYSB) administered four times per day for 4 weeks to increase noninvasive tear film break-up time (NITFBUT) over baseline compared with a saline (SAL) control in patients with lipid-deficient dry eye (DE). Patients aged ≥18 years with DE and evidence of meibomian gland dysfunction (ie, abnormal gland expression and missing meibomian glands) were included in this randomized, parallel-group, controlled, investigator-masked comparison study. Patients were randomized to SYSB or SAL four times daily for 4 weeks. The primary efficacy variable was mean change in NITFBUT from baseline at week 4. Ocular surface staining, goblet cell density, and meibomian gland expression were also assessed. Safety assessments included adverse events (AEs), best-corrected visual acuity, and ocular signs. A total of 49 patients received study treatments (SYSB, n=25; SAL, n=24). Most patients were women (67.4%) and Caucasian (63.3%); mean ± standard deviation (SD) age was 44±19 years. DE characteristics at baseline were similar between groups. After 4 weeks of treatment, the mean ± SD NITFBUT increase from baseline was significantly greater with SYSB (2.83±0.74 seconds) compared with SAL (0.66±0.55 seconds; P<0.001, t-test). Improvements in conjunctival and corneal staining, percentage of patients with increased goblet cell density, and meibomian gland expression were also observed with 4 weeks of SYSB over SAL. No AEs were reported for either treatment group; best-corrected visual acuity and ocular signs remained stable or improved compared with baseline. SYSB restored tear film stability, improved ocular surface healing, and improved meibomian gland functionality after 4 weeks of use in patients with lipid-deficient DE. No AEs were reported with either SYSB or SAL.

Salvianolic Acid B Ameliorates Motor Dysfuntion in Spinal Cord ...

African Journals Online (AJOL)

Purpose: To evaluate the effect of salvianolic acid B (Sal B) treatment on the motor function of spinal cord injury (SCI) rat. Methods: SCI rats were modelled by contusion, and then received 10 mg/kg Sal B, or methylprednisolone, or phosphate-buffered saline (PBS) intraperitoneally daily for 4 weeks, two hours after the ...

Persistent hypertension and progressive renal injury induced by salt overload after short term nitric oxide inhibition Hipertensão persistente e lesão renal progressiva induzidas por sobrecarga de sal após inibição temporária do óxido nítrico

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Ana Lúcia Mattar

2007-01-01

em sal (HS promove albuminúria e dano renal graves, reversíveis ao interromperem-se os tratamentos. OBJETIVO: Investigamos se tais alterações recrudescem ao reinstituir-se a HS e se são prevenidas pelo micofenolato mofetil (MMF, um agente antilinfócito, ou losartan, um bloqueador do receptor AT-1. MATERIAL E MÉTODOS: Ratos Münich-Wistar machos adultos receberam NAME e HS. Um grupo controle (C recebeu apenas HS. Após 20 dias, os ratos que receberam HS e NAME exibiam hipertensão e albuminúria graves. Após recuperação de 30 dias, a hipertensão atenuou-se e a albuminúria praticamente desapareceu. Formaram-se então os grupos: HS, recebendo HS; NS, recebendo dieta normal em sal (NS; HS-MMF, recebendo HS e MMF; HS-LOS, recebendo HS e losartan; HS-HDZ, recebendo HS e hidralazina. Após sessenta dias os ratos NS tinham albuminúria e dano/inflamação renal apenas discretos. Já os ratos HS desenvolveram hipertensão e glomerulosclerose acentuadas, expansão intersticial e infiltração renal por macrófagos e células positivas para angiotensina II. Losartan baixou a pressão arterial e preveniu albuminúria e lesão renal. MMF proporcionou proteção semelhante sem alteração pressórica, sugerindo a ação de mecanismos não hemodinâmicos, hipótese reforçada pelo achado de que a HDZ baixou a pressão arterial sem prevenir a nefropatia. RESULTADOS: Esses resultados indicam que o tratamento com HS e NAME predispõe ao desenvolvimento de hipertensão e lesão renal induzidos por excesso de sal, caracterizando um novo modelo de nefropatia crônica. CONCLUSÃO: A resposta ao MMF ou losartan, mas não à hidralazina, sugere o predomínio de fatores inflamatórios.

Simulating the formation of Hurricane Isabel (2003) with AIRS data

Science.gov (United States)

Wu, Liguang; Braun, Scott A.; Qu, John J.; Hao, Xianjun

2006-02-01

Using the AIRS retrieved temperature and humidity profiles, the Saharan Air Layer (SAL) influence on the formation of Hurricane Isabel (2003) is simulated numerically with the MM5 model. The warmth and dryness of the SAL (the thermodynamic effect) is assimilated by use of the nudging technique, which enables the model thermodynamic state to be relaxed to the profiles of the AIRS retrieved data for the regions without cloud contamination. By incorporating the AIRS data, MM5 better simulates the large-scale flow patterns and the timing and location of the formation of Hurricane Isabel and its subsequent track. By comparing with an experiment without nudging of the AIRS data, it is shown that the SAL may have delayed the formation of Hurricane Isabel and inhibited the development of another tropical disturbance to the east. This case study confirms the argument by Dunion and Velden (2004) that the SAL can suppress Atlantic tropical cyclone activity by increasing the vertical wind shear, reducing the mean relative humidity, and stabilizing the environment at lower levels.

Two Ti13-oxo-clusters showing non-compact structures, film electrode preparation and photocurrent properties.

Science.gov (United States)

Hou, Jin-Le; Luo, Wen; Wu, Yin-Yin; Su, Hu-Chao; Zhang, Guang-Lin; Zhu, Qin-Yu; Dai, Jie

2015-12-14

Two benzene dicarboxylate (BDC) and salicylate (SAL) substituted titanium-oxo-clusters, Ti13O10(o-BDC)4(SAL)4(O(i)Pr)16 (1) and Ti13O10(o-BDC)4(SAL-Cl)4(O(i)Pr)16 (2), are prepared by one step in situ solvothermal synthesis. Single crystal analysis shows that the two Ti13 clusters take a paddle arrangement with an S4 symmetry. The non-compact (non-sphere) structure is stabilized by the coordination of BDC and SAL. Film photoelectrodes are prepared by the wet coating process using the solution of the clusters and the photocurrent response properties of the electrodes are studied. It is found that the photocurrent density and photoresponsiveness of the electrodes are related to the number of coating layers and the annealing temperature. Using ligand coordinated titanium-oxo-clusters as the molecular precursors of TiO2 anatase films is found to be effective due to their high solubility, appropriate stability in solution and hence the easy controllability.

Tolerância ao sal e às altas temperaturas de estirpes de Sinorhizobium provenientes de zonas secas do Alentejo Salt and temperature tolerance of Sinorhizobium strains isolated from dry environments in Alentejo

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P. Fareleira

2007-07-01

Full Text Available O trabalho teve como principal objectivo a obtenção de estirpes de rizóbio adequadas à nodulação de luzernas anuais e adaptadas a sobreviver nas condições ambientais susceptíveis de ocorrer em solos degradados. Dado que as populações de rizóbio apresentam variabilidade considerável no que respeita à tolerância a factores ambientais, os estudos focaram-se na pesquisa e na selecção de estirpes resistentes a condições adversas. Efectuaram-se colheitas de solos em diversas zonas no sul do País, seleccionando-se locais afectados por secura, temperaturas elevadas e, pontualmente, salinidade. A partir destes solos, isolaram-se estirpes de rizóbio, usando como planta hospedeira a luzerna anual Medicago polymorpha. Estudaram-se os efeitos de condições de stresse ambiental, como a salinidade e as altas temperaturas, no crescimento das estirpes isoladas. Dos 41 isolamentos analisados, 11 apresentaram crescimento em meio con-tendo 1,4 M de cloreto de sódio e suplementado com 10% de extracto de terra, e 22 cresceram quando incubadas a 45 ºC em meio sem aditivos. Três estirpes mostraram ter capacidade para crescer sob os efeitos conjuntos da salinidade e da alta temperatura. A análise de extractos etanólicos de estirpes tolerantes à salinidade revelou, na maior parte dos casos, a acumulação, induzida pelo sal, dos solutos compatíveis de Sinorhizobium: o dipéptido N - acetilglutaminilglutamina amida, vários tipos de betaínas, trealose, glutamato e prolina. A observação, por NMR de 31P in vivo, de uma estirpe tolerante ao sal, proveniente de um solo xistoso de baixo teor em fósforo, mostrou a presença de níveis elevados de reservas intracelulares de fosfato inorgânico (polifosfato, sugerindo um bom potencial para utilização em solos onde os riscos de salinização se conjuguem com deficiências em fósforo assimilável.The main objective of this work was to obtain rhizobial strains able to nodulate annual medics and

Sinop Yarımadası (Güney Karadeniz Kıyısal Sularındaki Bazı Syngnathid Türlerinin (Syngnathus sp., Nerophis sp., Hippocampus sp. Besin Kompozisyonları

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Şule GÜRKAN

2012-09-01

Full Text Available Bu araştırmada, Temmuz 2001 - Mayıs 2002 tarihleri arasında Sinop yarımadası (güney Karadeniz kıyısal sularının 5 – 15 m derinliklerindeki farklı biyotoplarından el direci kullanılarak yakalanan 6 deniziğnesi (Syngnathus acus Linnaeus, 1758; Syngnathus typhle Linnaeus, 1758; Syngnathus tenurostris Rathke, 1837; Syngnathus variegatus Palas, 1811; Nerophis ophidion Linnaeus, 1758; Syngnathus abaster Risso,1926 ve bir denizatı (Hippocampus hippocampus (L.,1758 türüne ait toplam 130 bireyde 105 mide içeriği incelenmiştir. Analizler sonunda mide içeriklerinde 13 av grubu tespit edilmiştir. Deniziğnesi türlerinin besin içeriğinde bulunuş frekans değeri (% F bakımından en baskın av grupları; S. acus’da % 90.9 Euterpina acutifrons, S. typhle’de % 93.3 tanımlanamamış doku parçaları, S. tenurostris’de % 87 Pseudocalanus elongatus, S. variegatus’da % 91.7 tanımlanamamış doku parçaları, N. ophidion’da % 90 Euterpina acutifrons, S. abaster’de ise % 100 Pseudocalanus elongatus, Euterpina acutifrons, Cirriped cypris, ve Cirriped nauiplius’dur. H. hippocampus ise % 25 ile Onceae sp. en baskın av grubudur. Sonuç olarak, deniziğnesi ve denizatı türlerinin esasen bentik ve planktonik krustase gruplarıyla beslendikleri görülmekle birlikte S. tenuirostris, S. abaster ve S. variegatus için besin kompozisyonu kıyılarımızdan ilk kez belirlenmiştir

A dieta com baixo teor de sódio é de fato indicada para todos os pacientes com insuficiência cardíaca estável? ¿La dieta con bajo nivel de sodio es de hecho una recomendación que sirve a todos los pacientes con insuficiencia cardíaca estable? Is the low-sodium diet actually indicated for all patients with stable heart failure?

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Miyoko Nakasato

2010-01-01

Full Text Available FUNDAMENTO: Embora uma dietahipossódica seja indicada para a insuficiência cardíaca IC, não há evidência de que esta restrição seja benéfica para todos os pacientes. OBJETIVO: Estudar prospectivamente os efeitos agudos de uma dieta hipossódica em pacientes (pcs com insuficiência cardíaca (IC. Métodos: Cinqüenta pacientes ambulatoriais estáveis, com IC leve a moderada, que relataram consumir previamente 6,6 g sal/dia foram estudados. Na Fase 1, todos os pcs foram submetidos a uma dieta com 2 g de sal durante 7 dias, seguido por randomização em dois subgrupos (fase 2, para receber 6 g de sal/dia (subgrupo 1 ou 2 g de sal/dia, por 7 dias (subgrupo II. RESULTADOS: Fase 1: a dieta com 2 g de sal/dia reduziu o índice de massa corporal (IMC, sódio plasmático e sódio urinário, consumo de proteína, ferro, zinco, selênio e vitamina B12; aumentou os níveis plasmáticos de norepinefrina, nitrato, aldosterona sérica, e melhorou a qualidade de vida. Fase 2: para pcs com IMC baixo, o uso de 6 g de sal/dia diminuiu de forma aguda os níveis de norepinefrina, albumina e colesterol no plasma. Nenhuma diferença foi encontrada em pcs com IMC mais alto. CONCLUSÃO: A dieta com 2g de sal /dia para pcs com IC aumentou a ativação neuro-hormonal associada à progressão da IC. O IMC pode influenciar a resposta da ativação neurohormonal em uma dieta hipossódica na IC. Futuros estudos para testar a restrição à ingestão de sal por períodos mais longos são recomendados.FUNDAMENTO: Aunque se indica una dieta hiposódica para la IC, no hay evidencia de que esta restricción es beneficiosa para todos los pacientes. OBJETIVO: Estudiar prospectivamente los efectos agudos de una dieta hiposódica en pacientes (pcs con insuficiencia cardíaca (IC. MÉTODOS: Fueron estudiados cincuenta pacientes ambulatorios estables con IC leve a moderada, que relataron consumir previamente 6,6 g sal/día. En la fase I, todos los pcs fueron sometidos a una

Die belangrikste kenmerk van die diereproduksie- bedrywe oor die ...

African Journals Online (AJOL)

digdhede teen 1980 uit 'n kudde van 30 rnilj.skape ge- produseer moet word. Tweedens sal die faktore ... die Republiek van Suid-Mrika teen 1980 in totaal 28 milj. sal wees. Indien die produsente dit as 'n ..... Appendix Table 4 in Digestive Physiology and nutrition of ruminants Vol. 3 Ed. and Publ. D.C. Church, Oregon State ...

Branching time, indeterminism and tense logic

DEFF Research Database (Denmark)

Ploug, Thomas; Øhrstrøm, Peter

2012-01-01

This paper deals with the historical and philosophical background of the introduction of the notion of branching time in philosophical logic as it is revealed in the hitherto unpublished mail-correspondence between Saul Kripke and A.N. Prior in the late 1950s. The paper reveals that the idea...... relativity. The correspondence underpins the point that Prior’s later development of branching time may be understood as a crucial part of his attempt at the formulating a conceptual framework integrating basic human notions of time and free choice....

Salidroside Suppresses HUVECs Cell Injury Induced by Oxidative Stress through Activating the Nrf2 Signaling Pathway

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Yao Zhu

2016-08-01

Full Text Available Oxidative stress plays an important role in the pathogenesis of cardiovascular diseases. Salidroside (SAL, one of the main effective constituents of Rhodiola rosea, has been reported to suppress oxidative stress-induced cardiomyocyte injury and necrosis by promoting transcription of nuclear factor E2-related factor 2 (Nrf2-regulated genes such as heme oxygenase-1 (HO-1 and NAD(PH dehydrogenase (quinone1 (NQO1. However, it has not been indicated whether SAL might ameliorate endothelial injury induced by oxidative stress. Here, our study demonstrated that SAL might suppress HUVEC cell injury induced by oxidative stress through activating the Nrf2 signaling pathway. The results of our study indicated that SAL decreased the levels of intercellular reactive oxygen species (ROS and malondialdehyde (MDA, and improved the activities of superoxide dismutase (SOD and catalase (CAT, resulting in protective effects against oxidative stress-induced cell damage in HUVECs. It suppressed oxidative stress damage by inducing Nrf2 nuclear translocation and activating the expression of Nrf2-regulated antioxidant enzyme genes such as HO-1 and NQO1 in HUVECs. Knockdown of Nrf2 with siRNA abolished the cytoprotective effects against oxidative stress, decreased the expression of Nrf2, HO-1, and NQO1, and inhibited the nucleus translocation of Nrf2 in HUVECs. This study is the first to demonstrate that SAL suppresses HUVECs cell injury induced by oxidative stress through activating the Nrf2 signaling pathway.

Evaluation of pharmacokinetics and pharmacodynamics relationships for Salvianolic Acid B micro-porous osmotic pump pellets in angina pectoris rabbit

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Shu-Ling Kan

2014-06-01

Full Text Available The work aims to investigate the in vitro release, pharmacokinetics (PK, pharmacodynamics (PD and PK–PD relationships of Salvianolic Acid B micro-porous osmotic pump pellets (SalB-MPOPs in angina pectoris New Zealand White (NZW rabbits, compared with those of SalB immediate-release pellets (SalB-IRPs. The SalB plasma concentrations and Superoxide dismutase levels (PD index were recorded continuously at predetermined time interval after administration, and the related parameters were calculated by using WinNonlin software. The release profile of MPOPs was more sustained than that of IRPs. PK results indicated that the mean Cmax was significantly lower, the SalB plasma concentrations were steadier, both area under concentration-time curve from 0 to 24 h (AUC0–24 h and from 0 to infinity (AUC0–∞ were presented larger, and both the peak concentration time (Tmax and mean residence time (MRT were prolonged for MPOPs, as compared with those of IRPs. PD results suggested that peak drug effect (Emax was lower and the equilibration rate constant (ke0 between the central compartment and the effect compartment was higher of MPOPs vs. those of IRPs. PK–PD relationships demonstrated that the effect-concentration-time (ECT course of MPOPs was clockwise hysteresis loop, and that of IRPs was counter-clockwise hysteresis loop. Collectively, those results demonstrated that MPOPs were potential formulations in treating angina pectoris induced by atherosclerosis.

Allergy to fish parvalbumins: studies on the cross-reactivity of allergens from 9 commonly consumed fish.

Science.gov (United States)

Van Do, Thien; Elsayed, Said; Florvaag, Erik; Hordvik, Ivar; Endresen, Curt

2005-12-01

Fish-hypersensitive patients can probably tolerate some fish species while being allergic to others. To determine the allergenic cross-reactivity between 9 commonly edible fish: cod, salmon, pollack, mackerel, tuna, herring, wolffish, halibut, and flounder. Sera from 10 patients allergic to fish and rabbit antisera against 3 parvalbumins (Gad c 1, Sal s 1, and The c 1) were used. Cross-reactivity was investigated by SDS/PAGE and IgE immunoblotting, IgG ELISA, IgE ELISA inhibition, and skin prick test (SPT). Cod (Gad c 1), salmon (Sal s 1), pollack (The c 1), herring, and wolffish share antigenic and allergenic determinants as shown by immunoblots and IgE ELISA, whereas halibut, flounder, tuna, and mackerel displayed lowest cross-reactivities. The highest mean IgE ELISA inhibition percent of 10 sera was obtained by Gad c 1, followed by The c 1, herring, Sal s 1, wolffish, halibut, flounder, tuna, and mackerel with the least inhibition. Nine of the 10 patients showed positive SPT to cod, salmon, and pollack; 8 patients reacted to recombinant (r) Sal s 1. Positive SPTs to rGad c 1 and rThe c 1 were demonstrated in 1 patient. Gad c 1, Sal s 1, The c 1, herring, and wolffish contained the most potent cross-reacting allergens, whereas halibut, flounder, tuna, and mackerel were the least allergenic in the current study. The latter could probably be tolerated by some of the tested patients.

Inflammatory Gene Expression in Whole Peripheral Blood at Early Stages of Sporadic Amyotrophic Lateral Sclerosis

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Pol Andrés-Benito

2017-10-01

Full Text Available ObjectiveCharacterization of altered expression of selected transcripts linked to inflammation in the peripheral blood of sporadic amyotrophic lateral sclerosis (sALS patients at early stage of disease to increase knowledge about peripheral inflammatory response in sALS.MethodsRNA expression levels of 45 genes were assessed by RT-qPCR in 22 sALS cases in parallel with 13 age-matched controls. Clinical and serum parameters were assessed at the same time.ResultsUpregulation of genes coding for factors involved in leukocyte extravasation (ITGB2, INPP5D, SELL, and ICAM1 and extracellular matrix remodeling (MMP9 and TIMP2, as well as downregulation of certain chemokines (CCL5 and CXC5R, anti-inflammatory cytokines (IL10, TGFB2, and IL10RA, pro-inflammatory cytokines (IL-6, and T-cell regulators (CD2 and TRBC1 was found in sALS cases independently of gender, clinical symptoms at onset (spinal, respiratory, or bulbar, progression, peripheral leukocyte number, and integrity of RNA. MMP9 levels positively correlated with age, whereas CCR5, CCL5, and TRBC1 negatively correlated with age in sALS but not in controls. Relatively higher TNFA expression levels correlate with higher creatinine kinase protein levels in plasma.ConclusionPresent findings show early inflammatory responses characterized by upregulation of factors enabling extravasation of leukocytes and extracellular matrix remodeling in blood in sALS cases, in addition to increased TNFA levels paralleling skeletal muscle damage.

Estimativa de consumo de sodio pela populacao brasileira, 2008-2009

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Flavio Sarno

2013-06-01

Full Text Available OBJETIVO: Atualizar estimativas sobre consumo de sódio no Brasil. MÉTODOS: Foram utilizados dados da Pesquisa de Orçamentos Familiares 2008-2009. Realizou-se a conversão em nutrientes dos registros de aquisição de alimentos dos domicílios brasileiros por meio de tabelas de composição de alimentos. Foram calculadas a disponibilidade média de sódio/pessoa/dia e a disponibilidade média ajustada para um consumo energético diário de 2.000 kcal. Calculou-se a contribuição de grupos de alimentos selecionados para o total de sódio disponível para consumo no domicílio e comparou-se com aqueles da Pesquisa de Orçamentos Familiares 2002-2003. RESULTADOS: A quantidade diária de sódio disponível para consumo nos domicílios brasileiros foi de 4,7 g para ingestão diária de 2.000 kcal, mantendo-se mais de duas vezes superior ao limite recomendado de ingestão desse nutriente. A maior parte do sódio disponível para consumo provém do sal de cozinha e de condimentos à base de sal (74,4%, mas a fração proveniente de alimentos processados com adição de sal aumentou linear e intensamente com o poder aquisitivo domiciliar (12,3% do total de sódio no quinto inferior da distribuição da renda por pessoa e 27,0% no quinto superior. Observou-se redução na contribuição de sal e condimentos à base de sal (76,2% para 74,4% e dos alimentos in natura ou processados sem adição de sal (6,6% para 4,8% e aumento dos alimentos processados com adição de sal (15,8% para 18,9% e dos pratos prontos (1,4% para 1,6% na comparação com a Pesquisa de Orçamentos Familiares 2002-2003. CONCLUSÕES: O consumo de sódio no Brasil mantém-se em níveis acima da recomendação máxima para esse nutriente em todas as macrorregiões e classes de renda brasileiras. Observou-se estabilidade na disponibilidade domiciliar total de sódio e aumento na fração proveniente dos alimentos processados com adição de sal e dos pratos prontos, na comparação de

Circulação estacionária e estratificação de sal em canais estuarinos: simulação com modelos analíticos Stationary circulation and salt stratification in estuarine channels: simulation with analitic models

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Marcos Eduardo Cordeiro Bernardes

2001-01-01

Full Text Available A circulação estacionária e a estratificação de sal na região sul do Sistema Estuarino-lagunar de Cananéia-Iguape e no Canal de Bertioga são descritas. Os modelos de Fisher el al. (1972, Prandle (1985 e Miranda (1998 foram escolhidos para a simulação dos perfis verticais do componente longitudinal da velocidade e da salinidade. Os dados experimentais utilizados na calibração desses modelos foram amostrados em 41 estações fixas de um ou dois ciclos de maré semidiurna. Os modelos reproduziram com boa fidelidade condições experimentais bem misturadas e parcialmente misturadas. O gradiente longitudinal de densidade e a descarga de água doce foram as principais forçantes da circulação estacionária e estratificação de sal, em detrimento da influência secundária da tensão de cisalhamento do vento. De acordo com o diagrama Estratificação-circulaçâo de Hansen & Rattray (1966, a região sul do sistema estuarino de Cananéia apresentou condições bem misturadas (Tipo 1a e parcialmente misturadas (Tipo 2b antes e depois do rompimento da barragem do Valo Grande, respectivamente. No Canal de Bertioga foram observadas condições parcialmente misturadas (Tipo 2b nas imediações do Rio Itapanhaú e bem misturadas (Tipo lb no restante do canal. Os coeficientes teóricos de viscosidade turbulenta foram similares aos calculados experimentalmente por Mesquita et al. (1992.The stationary circulation and salinity stratification in the southern region of Cananéia-Iguape Estuarine-lagoon System and Bertioga Channel are described. The models of Fisher el al. (1972, Prandle (1985 and Miranda (1998 were selected for the simulation of vertical profiles of the longitudinal component of velocity and salinity. The experimental data set used for the calibration of these models were sampled in 41 anchored stations, for one or two semidiurnal tidal cycles. For well mixed and partially mixed conditions, theoretical results and experimental data

Comments on "Atlantic Tropical Cyclogenetic Processes during SOP-3 NAMMA in the GEOS-5 Global Data Assimilation and Forecast System"

Science.gov (United States)

Braun, Scott A.

2010-01-01

Considerable attention has been given to the potential negative impacts of the Saharan air layer (SAL) in recent years. Researchers recently raised questions about the negative impacts of Dunion and Velden and other studies in terms of storms that reached at least tropical storm strength and suggested that the SAL was an intrinsic part of the tropical cyclone environment for both storms that weaken after formation and those that intensify. Braun also suggested that several incorrect assumptions underlie many of the studies on the negative impacts of the SAL, including assumptions that most low-to-midlevel dry tropical air is SAL air, that the SAL is dry throughout its depth, and that the proximity of the SAL to storms struggling to intensify implies some role in that struggle. The recent paper by Reale et al.(RL1) is an example of the problems inherent in some of these assumptions. In their paper, RL1 analyze a simulation from the Global Earth Observing System (GEOS-5) global model and describe an extensive tongue of warm, dry air that stretches southward from at least 30 deg N (the northern limit of their plots) and wraps into a low pressure system during the period 26-29 August 2006, suppressing convection and possibly development of the African easterly wave associated with that low pressure system. They attributed the warm, dry tongue to the SAL (i.e., heating of the air mass during passage over the Sahara and radiative warming of the dust layer). Whether it was their intention, the implication is that this entire feature is due solely to the SAL and not to other possible sources of dry air or warmth. In addition, they suggested that a cool tongue of air in the boundary layer located directly beneath the elevated warm, dry tongue (forming a thermal dipole) was possibly the result of reduced solar radiation caused by an overlying dust layer. They stated that "the cool anomaly in the lower levels does not have any plausible explanation relying only on transport

Puitmaja klaster : intervjuu Argo Sauliga / Argo Saul ; intervjueerinud Kalle Komissarov

Index Scriptorium Estoniae

Saul, Argo

2010-01-01

Eesti Puitmajaliidu juhatuse esimehe ning Nordic Houses osaniku ja juhatuse esimehe Argo Sauliga arhitektide ja tüüpmaja tootjate võimalikust koostööst Eesti puitmaja klastris, millega Eesti Arhitektide Liit on liitunud. Nordic Houses on norra arhitektide projektide järgi tootnud ja tarninud üle 700 puhkemaja Norrasse

Pentateugtradisies in die boek Hosea

African Journals Online (AJOL)

om te bepaal of die verwysing na 'n gebeure te doen het met die verre verlede of met die .... Hosea 2:1-2 JHWH se trou aan sy beloftes. ... dat huile na Egipte sal terugkeer. Die presiese bedoeiing van die woorde 'huile sal terugkeer na Egipte' is omstre- de. Kommentatore soos Rudolph meen dat dit verstaan moet word as ...

Leipoldt in 1980*

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H. M. Viljoen

1980-03-01

Full Text Available Oor Leipoldt se veelsydigheid hoef daar nie veel gésê te word nie. Hy was digter, dramaturg, romanskrywer, joemalis, geneesheer, kos- en wynkenner, filantroop, wêreldburger, maar bly tog vir ons in die eerste plek digter. Ons beeld van Leipoldt so oeuvre kan verander - daar is vanjaar al twee “nuwe” werke van hom ontdek - maar as daar iets van Leipoldt behoue sal bly, sal dit eerder sy poësie as sy drama, prosa, joemalistieke werk of kookboeke wees; so lyk dit altans op die oomblik. Daarom beperk ek my to t sy poësie en sal ek nie probeer om u totaalbeeld van sy ryk maar erg ongelyke oeuvre te gee nie.

An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children.

Science.gov (United States)

Köse, Osman; Özmen, İbrahim; Arca, Ercan

2013-08-01

To evaluate and compare the safety and efficacy of 10% potassium hydroxide (KOH) solution and salicylic and lactic acid (SAL + LAC) combination in the treatment of molluscum contagiosum (MC). 26 patients with MC randomized into two treatment groups. 12 patients treated with 10% KOH solution and 14 patients treated with SAL + LAC combination for 6 weeks. Parents of patients were instructed to apply medication once daily only to lesions at study onset. Assessment of response of the treated lesions and side effects was performed at 2, 4 and 6 weeks of the treatment. Newly acquired lesions were not included in the study. At the end of therapy, 83.3% (n = 10) of KOH group demonstrated complete remission and 16.7% (n = 2) of them showed partial remission; four patients (33%) developed new lesions during the study. All the patients in the SAL + LAC combination group (100%) demonstrated complete remission of study entry lesions at the end of 6 weeks with five patients (35%) acquiring new lesions during the study. Minor side effects were observed in two groups. 10% KOH solution and SAL + LAC combination were found to be equally effective in the treatment of MC in children.

Comportamiento viscoelástico lineal de soluciones acuosas de ctab/nasal

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Jesús Ramiro Aragón Guajardo

2015-05-01

Full Text Available En este trabajo se lleva a cabo un estudio de los comportamientos viscoelásticos lineales de disoluciones acuosas de Bromuro de Cetiltrimetilamonio (CTAB/Salicilato de Sodio (NaSal variándose tanto la temperatura como la concentración de NaSal. La concentración de CTAB se mantuvo constante en 100 mM, mientras que la concentración de NaSal se varió en el intervalo de 35 a 500 mM a las temperaturas de medición de 25, 30 y 35ºC. Los resultados de viscosidad estática indican que el sistema exhibe cuatro regiones con igual número de transiciones estructurales de micelas alargadas filiformes en función de la concentración de NaSal y de la temperatura. Los análisis viscoelásticos fueron llevados a cabo utilizando los modelos mecánicos de Maxwell y Hess, permitiendo obtener una correlación entre la viscoelasticidad lineal oscilatoria, por medio de los espectros de tiempos de relajación, y las diferentes estructuras micelares de cada una de las diferentes regiones del diagrama fisicoquímico dinámico.

Mediji un populisms: ASV mediju dienaskārtība un ziņu atspoguļojums kā veicinošs faktors Donalda Trampa priekšvēlēšanu kampaņas atbalstam. 2011. un 2015. gada ziņu raidījumu salīdzinošā analīze

OpenAIRE

Aleksejeva, Santa

2017-01-01

Maģistra darba tēmas ir “Mediji un populisms: ASV mediju dienaskārtība un ziņu atspoguļojums kā veicinošs faktors Donalda Trampa priekšvēlēšanu kampaņas atbalstam. 2011. un 2015. gada ziņu raidījumu salīdzinošā analīze”. Pētījuma mērķis ir izpētīt mediju un populisma saikni un apstiprināt hipotēzi, ka mediju veidotā dienaskārtība un ziņu atspoguļojums par brīvo tirdzniecību, Pieejmās Aprūpes likumu un imigrāciju ASV televīzijas kanālos CNN, MSNBC un FOX News 2015. gadā ir veicinājis sabiedrīb...

AVALIAÇÃO DA QUALIDADE E COMPOSIÇÃO DE TEMPEROS ALHO E SAL INDUSTRIALIZADOS, COMERCIALIZADOS NA CIDADE DE JUIZ DE FORA

Directory of Open Access Journals (Sweden)

WALTER DE CARVALHO

2009-07-01

Full Text Available

Este trabalho teve como objetivo estabelecer um perfil de composição físicoquímica, microscópica e sensorial de temperos do tipo alho e sal industrializados. Foram analisadas trinta amostras, coletadas ao acaso no varejo do município de Juiz de Fora - MG. Os resultados demonstraram ausência de padronização quanto à qualidade microbiológica, aspectos sensoriais e rotulagem Observou-se excessiva concentração de cloreto de sódio nas amostras, com valores percentuais variando entre 69 e 93,22 e média aritmética de 83,74. O teor de umidade variou de 5,76 a 25,54, com média aritmética de 12,08 (valores percentuais Com relação às amostras, 4,17% delas encontraram-se em desacordo com a legislação vigente no que diz respeito à contagem de bolores e leveduras. A microscopia não se mostrou eficiente para verificar a composição deste produto, impossibilitando a detecção de possíveis adulterações com cebola. Preparou-se um tempero-padrão com base nos valores médios de composição, o qual foi submetido às mesmas análises, apresentando composição de 83,78% de cloreto de sódio e 10,63% de umidade. Constatou -se a necessidade de fixação de especificações para teores máximos de cloreto de sódio e umidade, padronização da rotulagem e adoção de boas práticas de fabricação como forma de garantir um produto de melhor qualidade ao consumidor.

Preservation of the Digital Culture: Archiving the World Wide Web Sayısal (Dijital Kültürün Korunması: Web Arşivleme

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Ahmet Aldemir

2006-09-01

Full Text Available Information growth in the web medium has required the necessity of archiving these information to transmit them to future generations. Web archiving is a versatile application which covers technical, legal and organizational dimensions. Any stage within the life cycle of digital information is critically important for the information in web environment. All over the world, many countries have started web archiving efforts through the leadership of their national libraries and attempted to carry these initiatives on a legal bases. In the light of these developments, this paper examines the necessity and major techniques in web archiving and it also discuss national and international web archiving projects. Web ortamında yaşanan bilgi artışı, beraberinde bu bilgilerin gelecek nesillere aktarılması amacıyla arşivlenmesi gereğini gündeme getirmiştir. Web'in arşivlenmesi teknik, yasal ve örgütsel boyutları olan çok yönlü bir uygulamadır. Sayısal ortamda üretilmiş bilginin yaşam döngüsündeki her bir aşama, web ortamında yer alan bilgiler için hayati önem taşımaktadır. Dünyada bir çok ülke milli kütüphaneleri öncülüğünde web arşivleme çalışmalarını başlatmış ve bu girişimlerinin yasal bir platforma taşınması için gerekli adımlar atılmıştır. Bu gelişmeler ışığında çalışmamızda, web'in neden arşivlenmesi gerektiğine değinilmiş, web arşivlemede kullanılan belli başlı yaklaşımlar ele alınmış, ulusal ve uluslararası ölçekli web arşivleme çalışmalarına yer verilmiştir.

Blood-CNS Barrier Impairment in ALS Patients versus an Animal Model

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Svitlana eGarbuzova-Davis

2014-02-01

Full Text Available Amyotrophic lateral sclerosis (ALS is a severe neurodegenerative disease with a compli-cated and poorly understood pathogenesis. Recently, alterations in the blood-Central Nervous System barrier (B-CNS-B have been recognized as a key factor possibly aggravating motor neuron damage. The majority of findings on ALS microvascular pathology have been deter-mined in mutant SOD1 rodent models, identifying barrier damage during disease develop-ment which might similarly occur in familial ALS patients carrying the SOD1 mutation. However, our knowledge of B-CNS-B competence in sporadic ALS (SALS has been limited. We recently showed structural and functional impairment in postmortem gray and white mat-ter microvessels of medulla and spinal cord tissue from SALS patients, suggesting pervasive barrier damage. Although numerous signs of barrier impairment (endothelial cell degenera-tion, capillary leakage, perivascular edema, downregulation of tight junction proteins, and microhemorrhages are indicated in both mutant SOD1 animal models of ALS and SALS pa-tients, other pathogenic barrier alterations have as yet only been identified in SALS patients. Pericyte degeneration, perivascular collagen IV expansion, and white matter capillary abnor-malities in SALS patients are significant barrier related pathologies yet to be noted in ALS SOD1 animal models. In the current review, these important differences in blood-CNS barrier damage between ALS patients and animal models, which may signify altered barrier transport mechanisms, are discussed. Understanding discrepancies in barrier condition between ALS patients and animal models may be crucial for developing effective therapies.

The relationship of salivary testosterone and male sexual dysfunction in opioid-associated androgen deficiency (OPIAD).

Science.gov (United States)

Ajo, Raquel; Segura, Ana; Mira, Laura; Inda, María-Del-Mar; Alfayate, Rocío; Sánchez-Barbie, Angel; Margarit, César; Peiró, Ana M

2017-03-01

Opioids are an effective treatment for chronic non-malignant pain (CNP). Long-term use risks and side effects such as opioid-induced androgen deficiency (OPIAD) exist. This could be measured by saliva testosterone (Sal-T). To evaluate OPIAD in long-term opioid use in CNP patients. A cross-sectional study included CNP male outpatients under opioid treatment. Total-Testosterone (Total-T), Free-Testosterone (Free-T), Bio-Testosterone (Bio-T) and Sal-T were measured. Correlations were calculated by Spearman's rho (SPSS 20). From 2012 to 2014, 134 from 249 (54%) consecutive male outpatients reported erectile dysfunction (ED), 37% of them related to opioids and 19% evidenced OPIAD. A total of 120 subjects (94 cases and 26 matched-controls) were included. A significantly lower luteinizing hormone, Total-T and Free-T were found, as well as, a significant correlation between Sal-T and Total-T (r = 0.234, p = 0.039), Bio-T (r = 0.241, p = 0.039), IIEF (r = 0.363, p = 0.003) and HAD-anxiety (r = -0.414, p = 0.012) in OPIAD patients. Sal-T levels were significantly lower in patients with severe-moderate ED versus mild ED (p = 0.045) and in patients with severe ED versus moderate-mild ED (p = 0.036). These data demonstrate the high prevalence of ED in long-term use of opioids, part of this is associated to OPIAD, which can be tested by Sal-T as a non-invasive approach.

Eraterritooriumile tunginud telekaamera juhmistab ettevõtted / Eda-Liis Kann

Index Scriptorium Estoniae

Kann, Eda-Liis, 1979-

2005-01-01

Info-Auto juht Viktor Siilats, Kanal 2 peadirektor Urmas Oru ja suhtekorraldusfirma In Nomine juht Heikki Sal-Saller eraettevõtete territooriumil filmimisest ja firma esindajate suhtlemisest ajakirjandusega juhtumi põhjal, kus Silber Auto teenindusega rahulolematu klient püüdis probleemi lahendada Kanal 2 vahendusel. Lisa: Avalikkusele esineb üks inimene. Kommenteerivad Nordic Foodsi juhatuse esimees Kuldar Leis ja In Nomine juht Heikki Sal-Saller

DIE PLEK VAN SANG EN MUSIEK IN DIE PROTESTANTSE ...

African Journals Online (AJOL)

Test

Sy moet hierdie opdrag uitvoer deur mid del van die Prediking d.w.s. deur middel van die Woord-vorm, maar ook deur die bediening van die sakramente, dws. deur middel van die vorm van die Daad. Maar nou wil God nie hê dat die Kerk slegs één maal die Evangelie sal predik en die mense sal doop om hulle daarna.

Effects of Systane® Balance on noninvasive tear film break-up time in patients with lipid-deficient dry eye

Directory of Open Access Journals (Sweden)

Aguilar AJ

2014-11-01

Full Text Available Alejandro J Aguilar, Maria I Marquez, Paula A Albera, Jorge L Tredicce, Alejandro Berra Universidad de Buenos Aires, Buenos Aires, Argentina Purpose: To evaluate the ability of Systane® Balance (SYSB administered four times per day for 4 weeks to increase noninvasive tear film break-up time (NITFBUT over baseline compared with a saline (SAL control in patients with lipid-deficient dry eye (DE.Patients and methods: Patients aged ≥18 years with DE and evidence of meibomian gland dysfunction (ie, abnormal gland expression and missing meibomian glands were included in this randomized, parallel-group, controlled, investigator-masked comparison study. Patients were randomized to SYSB or SAL four times daily for 4 weeks. The primary efficacy variable was mean change in NITFBUT from baseline at week 4. Ocular surface staining, goblet cell density, and meibomian gland expression were also assessed. Safety assessments included adverse events (AEs, best-corrected visual acuity, and ocular signs.Results: A total of 49 patients received study treatments (SYSB, n=25; SAL, n=24. Most patients were women (67.4% and Caucasian (63.3%; mean ± standard deviation (SD age was 44±19 years. DE characteristics at baseline were similar between groups. After 4 weeks of treatment, the mean ± SD NITFBUT increase from baseline was significantly greater with SYSB (2.83±0.74 seconds compared with SAL (0.66±0.55 seconds; P<0.001, t-test. Improvements in conjunctival and corneal staining, percentage of patients with increased goblet cell density, and meibomian gland expression were also observed with 4 weeks of SYSB over SAL. No AEs were reported for either treatment group; best-corrected visual acuity and ocular signs remained stable or improved compared with baseline.Conclusion: SYSB restored tear film stability, improved ocular surface healing, and improved meibomian gland functionality after 4 weeks of use in patients with lipid-deficient DE. No AEs were reported

Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties

International Nuclear Information System (INIS)

Liu, Miao; Zheng, Mingjing; Xu, Hanying; Liu, Lianqing; Li, Yanchun; Xiao, Wei; Li, Jianchun; Ma, Enlong

2015-01-01

Various methods have been used to evaluate anti-fibrotic activity of drugs. However, most of them are complicated, labor-intensive and lack of efficiency. This study was intended to develop a rapid method for anti-fibrotic drugs screening based on biophysical properties. A549 cells in vitro were stimulated with transforming growth factor-β1 (TGF-β1), and fibrogenesis was confirmed by conventional immunological assays. Meanwhile, the alterations of cyto-biophysical properties including morphology, roughness and stiffness were measured utilizing atomic force microscopy (AFM). It was found that fibrogenesis was accompanied with changes of cellular biophysical properties. TGF-β1-stimulated A549 cells became remarkably longer, rougher and stiffer than the control. Then, the effect of N-acetyl-L-cysteine (NAC) as a positive drug on ameliorating fibrogenesis in TGF-β1-stimulated A549 cells was verified respectively by immunological and biophysical markers. The result of Principal Component Analysis showed that stiffness was a leading index among all biophysical markers during fibrogenesis. Salvianolic acid B (SalB), a natural anti-oxidant, was detected by AFM to protect TGF-β1-stimulated A549 cells against stiffening. Then, SalB treatment was provided in preventive mode on a rat model of bleomycin (BLM) -induced pulmonary fibrosis. The results showed that SalB treatment significantly ameliorated BLM-induced histological alterations, blocked collagen accumulations and reduced α-SMA expression in lung tissues. All these results revealed the anti-pulmonary fibrotic activity of SalB. Detection of cyto-biophysical properties were therefore recommended as a rapid method for anti-pulmonary fibrotic drugs screening. - Highlights: • Fibrogenesis was accompanied with the changes of cyto-biophysical properties. • Cyto-biophysical properties could be markers for anti-fibrotic drugs screening. • Stiffness is a leading index among all biophysical markers. • SalB was

Acute Impact of Inhaled Short Acting B-Agonists on 5 Km Running Performance

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John Dickinson

2014-06-01

Full Text Available Whilst there appears to be no ergogenic effect from inhaled salbutamol no study has investigated the impact of the acute inhalation of 1600 µg, the World Anti-Doping Agency (WADA daily upper limit, on endurance running performance. To investigate the ergogenic effect of an acute inhalation of short acting β2-agonists at doses up to 1600 µg on 5 km time trial performance and resultant urine concentration. Seven male non-asthmatic runners (mean ± SD; age 22.4 ± 4.3 years; height 1.80 ± 0.07 m; body mass 76.6 ± 8.6 kg provided written informed consent. Participants completed six 5 km time-trials on separate days (three at 18 °C and three at 30 °C. Fifteen minutes prior to the initiation of each 5 km time-trial participants inhaled: placebo (PLA, 800 µg salbutamol (SAL800 or 1600 µg salbutamol (SAL1600. During each 5 km time-trial HR, VO2, VCO2, VE, RPE and blood lactate were measured. Urine samples (90 ml were collected between 30-180 minutes post 5 km time-trial and analysed for salbutamol concentration. There was no significant difference in total 5 km time between treatments (PLA 1714.7 ± 186.2 s; SAL800 1683.3 ± 179.7 s; SAL1600 1683.6 ± 190.7 s. Post 5 km time-trial salbutamol urine concentration between SAL800 (122.96 ± 69.22 ug·ml-1 and SAL1600 (574.06 ± 448.17 ug·ml-1 were not significantly different. There was no improvement in 5 km time-trial performance following the inhalation of up to 1600 µg of salbutamol in non-asthmatic athletes. This would suggest that the current WADA guidelines, which allow athletes to inhale up to 1600 µg per day, is sufficient to avoid pharmaceutical induced performance enhancement.

Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties

Energy Technology Data Exchange (ETDEWEB)

Liu, Miao; Zheng, Mingjing; Xu, Hanying [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016 (China); Liu, Lianqing [Shenyang Institute of Automation China Academy of Sciences, Shenyang, 110016 (China); Li, Yanchun [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016 (China); Xiao, Wei [Jiangsu Kanion Pharmaceutical Co., Ltd., Nanjing, 222001 (China); Li, Jianchun, E-mail: lijianchun0317@sina.com.cn [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016 (China); Ma, Enlong, E-mail: enlong_ma2014@hotmail.com [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016 (China); Jiangsu Kanion Pharmaceutical Co., Ltd., Nanjing, 222001 (China)

2015-12-04

Various methods have been used to evaluate anti-fibrotic activity of drugs. However, most of them are complicated, labor-intensive and lack of efficiency. This study was intended to develop a rapid method for anti-fibrotic drugs screening based on biophysical properties. A549 cells in vitro were stimulated with transforming growth factor-β1 (TGF-β1), and fibrogenesis was confirmed by conventional immunological assays. Meanwhile, the alterations of cyto-biophysical properties including morphology, roughness and stiffness were measured utilizing atomic force microscopy (AFM). It was found that fibrogenesis was accompanied with changes of cellular biophysical properties. TGF-β1-stimulated A549 cells became remarkably longer, rougher and stiffer than the control. Then, the effect of N-acetyl-L-cysteine (NAC) as a positive drug on ameliorating fibrogenesis in TGF-β1-stimulated A549 cells was verified respectively by immunological and biophysical markers. The result of Principal Component Analysis showed that stiffness was a leading index among all biophysical markers during fibrogenesis. Salvianolic acid B (SalB), a natural anti-oxidant, was detected by AFM to protect TGF-β1-stimulated A549 cells against stiffening. Then, SalB treatment was provided in preventive mode on a rat model of bleomycin (BLM) -induced pulmonary fibrosis. The results showed that SalB treatment significantly ameliorated BLM-induced histological alterations, blocked collagen accumulations and reduced α-SMA expression in lung tissues. All these results revealed the anti-pulmonary fibrotic activity of SalB. Detection of cyto-biophysical properties were therefore recommended as a rapid method for anti-pulmonary fibrotic drugs screening. - Highlights: • Fibrogenesis was accompanied with the changes of cyto-biophysical properties. • Cyto-biophysical properties could be markers for anti-fibrotic drugs screening. • Stiffness is a leading index among all biophysical markers. • SalB was

Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia–reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice

Directory of Open Access Journals (Sweden)

Feng J

2017-07-01

Full Text Available Jiao Feng,1,* Qinghui Zhang,2,* Wenhui Mo,3,* Liwei Wu,1 Sainan Li,1 Jingjing Li,1 Tong Liu,1 Shizan Xu,4 Xiaoming Fan,5 Chuanyong Guo1 1Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 2Department of Clinical Laboratory, Kunshan First People’s Hospital Affiliated to Jiangsu University, Kunshan, JiangSu, 3Department of Gastroenterology, Minhang Hospital, Fudan University, Shanghai, 4Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai, 5Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai, China *These authors contributed equally to this work Abstract: Ischemia–reperfusion injury (IRI contributes to liver damage in many clinical situations, such as liver resection and liver transplantation. In the present study, we investigated the effects of the antioxidant, anti-inflammatory, and anticancer agent salidroside (Sal on hepatic IRI in mice. The mice were randomly divided into six groups: normal control, Sham, Sal (20 mg/kg, IRI, IRI + Sal (10 mg/kg, and IRI + Sal (20 mg/kg. We measured liver enzymes, proinflammatory cytokines, TNF-α and interleukin-6, and apoptosis- and autophagy-related marker proteins at 2, 8, and 24 hours after reperfusion. Components of mitogen-activated protein kinase (MAPK signaling, including P-38, jun N-terminal kinase (JNK, and extracellular signal-regulated kinase (ERK, were also measured using an MAPK activator anisomycin to deduce their roles in hepatic IRI. Our results show that Sal safely protects hepatocytes from IRI by reducing levels of liver enzymes in the serum. These findings were confirmed by histopathology. We concluded that Sal protects hepatocytes from IRI partly by inhibiting the activation of MAPK signaling, including the phosphorylation of P38, JNK, and ERK. This ameliorates inflammatory reactions, apoptosis, and

A RELATIONAL DATABASE APPROACH TO THE JOB SHOP SCHEDULING PROBLEM

Directory of Open Access Journals (Sweden)

P. Lindeque

2012-01-01

Full Text Available

ENGLISH ABSTRACT: This paper will attempt to illuminate the advantages of an approach to the job shop scheduling problem using priority based search algorithms and database technology. It will use as basis a system developed for and implemented at a large manufacturing plant. The paper will also attempt to make some predictions as to future developments in these techniques and look at the possibility of including new technologies such as expert systems.

AFRIKAANSE OPSOMMING: Die voordele en toepaslikheid van prioriteits-gebaseerde soek-algoritmes en databasisstelsels op die taakwerkswinkelprobleem sal in hierdie artikel uitgelig word. 'n Stelsel wat by 'n groot vervaardigingsonderneming geimplementeer is, sal as uitgangspunt gebruik word. Toekomstige ontwikkelings in bogenoemde tegnieke en die moontlike insluiting van ekspertstelsels sal ook ondersoek word.

Editorial

Directory of Open Access Journals (Sweden)

Jo Mynard

2012-09-01

Full Text Available Issues of SiSAL Journal have a good international representation and this current issue is no exception. Contributions come from Mexico, Hong Kong, Japan and Iran. Although this is a general issue of SiSAL Journal, I have identified some salient themes coming through in the articles. These are: training for autonomous learning; scaffolding self-access use; and beliefs about learning and using the L2.

An appropriate level for reactor regulatory research

International Nuclear Information System (INIS)

Budnitz, R.J.; Kouts, H.J.C.

1986-01-01

In this brief paper the appropriate role for NRC's research program is set down, based on the experience of the last decade; and the broad outlines of an appropriate research program for the next decade are discussed. The two authors bring to this topic direct personal experience: they are two of only three former directors of NRC's research program in its history (the other was the last Saul Levine). The discussion considers only reactor safety research, although NRC's research program covers several other areas as well. Safeguards, environmental and health studies, waste management, and transportation are not covered

In Celebration of Past, Present and Future

DEFF Research Database (Denmark)

Hasle, Per Frederik Vilhelm; Jakobsen, David; Øhrstrøm, Peter

2018-01-01

of determinism led him to a reconstruction of the famous Diodorean Master Argument which had for centuries been regarded as a strong argument in favour of determinism. In his further analysis of the problem, he made extensive use of tense-logic and the idea of branching time suggested to him by Saul Kripke....... However, in Past, Present and Future Prior also stresses that time as such should not simply be understood in terms of branching time diagrams. Such diagrams should be seen not as direct representations of time but rather as figures helpful for understanding a deeper tense-logical structure....

Normalização da estatura e excesso de adiposidade corporal em crianças com a forma perdedora de sal da deficiência da 21-hidroxilase

Directory of Open Access Journals (Sweden)

Carolina T Mendes-dos-Santos

2011-06-01

Full Text Available OBJETIVO: Avaliar crescimento e composição corporal de portadores da forma clássica perdedora de sal da hiperplasia adrenal congênita por deficiência da 21-hidroxilase, comparando-os com crianças saudáveis. MÉTODOS: Foram incluídos 21 pacientes (oito meninos e 13 meninas, entre 2,1 e 10,2 anos, e 67 controles pré-púberes (36 meninos e 31 meninas, entre 1,2 e 11,7 anos. Avaliou-se peso, estatura, perímetro braquial, dobras cutâneas, composição corporal por bioimpedância e idade óssea. Foram obtidas dos prontuários dos pacientes as seguintes informações: estatura dos pais, valores de 17-OH progesterona e Δ4-androstenediona, dose de hidrocortisona prescrita, dados de peso e estatura ao nascimento, no início do tratamento e aos 2 anos de idade. RESULTADOS: Os pacientes apresentaram menor escore z de peso e de altura na primeira consulta em relação à situação de nascimento, com posterior recuperação após o início do tratamento, sem apresentar avanço da idade óssea. A média do escore z da altura dos controles (0,28±0,86 foi maior que a dos casos (-0,61±0,99, p < 0,001. Essa diferença desaparece quando se ajusta a altura dos pacientes para a idade óssea (0,33±1,68, p = 0,912. Os pacientes apresentaram maiores índices de massa corporal (p < 0,001, massa gorda (p < 0,001 e índice de massa gorda (p < 0,001 do que os controles. Não houve diferença entre as dobras cutâneas dos 2 grupos (p = 0,157. CONCLUSÕES: Os pacientes apresentaram recuperação do crescimento com média de estatura semelhante à da população geral, porém com maior adiposidade corporal, que parece ser visceral, já que não houve diferença entre as dobras cutâneas.

The radioactive waste management at IAEA laboratories

International Nuclear Information System (INIS)

Deron, S.; Ouvrard, R.; Hartmann, R.; Klose, H.

1992-10-01

The report gives a brief description of the nature of the radioactive wastes generated at the IAEA Laboratories in Seibersdorf, their origin and composition, their management and monitoring. The management of the radioactive waste produced at IAEA Laboratories in Seibersdorf is governed by the Technical Agreements of 1985 between the IAEA and the Austrian Health Ministry. In the period of 1982 to 1991 waste containers of low activity and radiotoxicity generated at laboratories other than the Safeguards Analytical Laboratory (SAL) were transferred to the FZS waste treatment and storage plant: The total activity contained in these drums amounted to < 65 MBq alpha activity; < 1030 MBq beta activity; < 2900 MBq gamma activity. The radioactive waste generated at SAL and transferred to the FZs during the same period included. Uranium contaminated solid burnable waste in 200 1 drums, uranium contaminated solid unburnable waste in 200 1 drums, uranium contaminated liquid unburnable waste in 30 1 bottles, plutonium contaminated solid unburnable waste in 200 1 drums. In the same period SAL received a total of 146 Kg uranium and 812 g plutonium and exported out of Austria, unused residues of samples. The balance, i.e.: uranium 39 kg, plutonium 133 g constitutes the increase of the inventory of reference materials, and unused residues awaiting export, accumulated at SAL and SIL fissile store as a result of SAL operation during this 10 year period. The IAEA reexports all unused residues of samples of radioactive and fissile materials analyzed at his laboratories, so that the amount of radioactive materials ending in the wastes treated and stored at FZS is kept to a minimum. 5 refs, 7 figs, 3 tabs

Screening of hypoxia-inducible genes in sporadic ALS.

LENUS (Irish Health Repository)

Cronin, Simon

2008-10-01

Genetic variations in two hypoxia-inducible angiogenic genes, VEGF and ANG, have been linked with sporadic amyotrophic lateral sclerosis (SALS). Common variations in these genes may reduce the levels or functioning of their products. VEGF and ANG belong to a larger group of angiogenic genes that are up-regulated under hypoxic conditions. We hypothesized that common genetic variation across other members of this group may also predispose to sporadic ALS. To screen other hypoxia-inducible angiogenic genes for association with SALS, we selected 112 tagging single nucleotide polymorphisms (tgSNPs) that captured the common genetic variation across 16 VEGF-like and eight ANG-like hypoxia-inducible genes. Screening for association was performed in 270 Irish individuals with typical SALS and 272 ethnically matched unrelated controls. SNPs showing association in the Irish phase were genotyped in a replication sample of 281 Swedish sporadic ALS patients and 286 Swedish controls. Seven markers showed association in the Irish. The one modest replication signal observed in the Swedish replication sample, at rs3801158 in the gene inhibin beta A, was for the opposite allele vs. the Irish cohort. We failed to detect association of common variation across 24 candidate hypoxia-inducible angiogenic genes with SALS.

EFEITOS DISTRIBUTIVOS DO SALÁRIO MÍNIMO NO MERCADO DE TRABALHO DA REGIÃO NORDESTE

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Joyciane Coelho Vasconcelos

Full Text Available RESUMO Este artigo investiga a contribuição do salário mínimo (SM no processo de desconcentração dos rendimentos do mercado de trabalho da região Nordeste do Brasil no período 2002-2012. Os microdados utilizados são oriundos da Pesquisa Nacional por Amostra de Domicílios (PNAD do Instituto Brasileiro de Geografia e Estatística (IBGE. Utilizou-se a metodologia de simulação proposta em DiNardo, Fortin e Lemieux (1996, que estimaram as funções densidade Kernel contrafactuais. As simulações foram realizadas para pessoas do gênero feminino e masculino. Os resultados revelaram que, por meio das decomposições, o salário mínimo, o grau de formalização e os atributos pessoais tiveram impactos desconcentradores naquele grupo de trabalhadores. Apenas para os homens, o efeito desconcentrador do salário mínimo é mais intenso na amostra quando comparado às mulheres. Em síntese, as simulações revelam a importância do salário mínimo na redução da dispersão dos rendimentos do trabalho no período estudado.

Neuromuscular performance of elite rugby union players and relationships with salivary hormones.

Science.gov (United States)

Crewther, Blair T; Lowe, Tim; Weatherby, Robert P; Gill, Nicholas; Keogh, Justin

2009-10-01

This study compared the neuromuscular performance (speed, power, strength) of elite rugby union players, by position, and examined the relationship between player performance and salivary hormones, by squad and position. Thirty-four professional male rugby players were assessed for running speed (10-m, 20-m or 30-m sprints), concentric mean (MP) and peak power (PP) during a 70-kg squat jump (SJ) and 50-kg bench press throw (BT), and estimated 1 repetition maximum (1RM) strength for a box squat (BS) and bench press (BP). Tests were performed on separate days with absolute and normalized (power and strength only) values computed. Saliva was collected before each test and assayed for testosterone (Sal-T) and cortisol (Sal-C). In absolute terms, the backs demonstrated greater speed and BT MP, whereas the forwards produced greater SJ PP and MP and BS 1RM (p 0.05). A comparison (absolute and normalized) of BT PP showed no positional differences (p > 0.05), whereas BP 1RM was greater for the forwards (p rugby. The Sal-T and/or Sal-C concentrations of players correlated to speed, power, and strength, especially for the backs (p benefit from acute and chronic hormone monitoring to identify those individuals likely to respond more to hormonal change.

Thompson Receives 2013 Early Career Hydrologic Science Award: Citation

Science.gov (United States)

Katul, Gabriel

2014-08-01

Sally Thompson grew up in Perth, where she was trained as an environmental engineer at the University of Western Australia. She graduated with honors in 2003 and worked for a few years as an environmental engineering consultant. Following the award of the Sir John Monash Fellowship in Australia, Sal accepted the admissions offer from the Nicholas School of the Environment at Duke University in 2006, completing her Ph.D. within 4 years and defending her dissertation in 2010. I was most fortunate to have Sal join me at Duke after an enthusiastic recommendation from Siva. Upon her arrival at Duke University, it was immediately clear to all that Sal is a special person with the remarkable skill of being able to identify the main aspects of a problem and throw at them the best that theory, experiment, and modeling tools offer.

Infiltração de sal de alumínio em fibras de sisal para obtenção de fibras de alumina Infiltration of aluminum salt into sisal to produce alumina fibers

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T. E. Andrade Jr.

2005-03-01

Full Text Available O sisal é um recurso estratégico para a região Nordeste e, particularmente, para o estado do Rio Grande do Norte, por ser uma cultura renovável e adaptada às condições do semi-árido. Em virtude das condições adversas de clima e solo, o sisal é, em algumas regiões, o único produto agrícola rentável passível de plantio. Agregar valor aos produtos manufaturados a partir do sisal contribui não só para o desenvolvimento científico e tecnológico da região, como também para a geração de renda para a população dos municípios potiguares produtores de sisal. Da planta extraem-se fibras ligninocelulósicas utilizadas na produção artesanal de cordas e industrial de mantas e tapetes. Uma outra alternativa é o aproveitamento da estrutura da fibra para a produção de fibras de alumina (Al2O3 pela biomodelagem. Este processo consiste na reprodução da estruturas natural do material de partida. O objetivo deste trabalho foi estudar as condições de infiltração da fibra de sisal com sal de alumínio para posterior conversão da estrutura em fibras de alumina. Inicialmente, as fibras de sisal foram pré-tratadas com hidróxido de sódio, infiltradas com uma solução saturada de sal de alumínio (Al2Cl6 e sinterizadas entre 1400 °C e 1650 °C. A caracterização das fibras de alumina foi feita por difração de raios X e microscopia eletrônica de varredura. Os resultados mostraram a conversão completa apenas da superfície da fibra de sisal em alfa-Al2O3, resultando em baixa resistência ao manuseio. Novos métodos de infiltração são propostos com o objetivo de reproduzir-se a estrutura interna da fibra de sisal, resultando em fibras materiais com melhor resistência mecânica.Sisal is a renewable agricultural resource adapted to the hostile climatic and soil conditions particularly encountered in the semi-arid areas of the state of Rio Grande do Norte, located in Northeastern Brazil. Consequently, sisal has played a

Association of low serum aluminum level with mortality in hemodialysis patients

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Hsu CW

2016-09-01

Full Text Available Ching-Wei Hsu,1–3 Cheng-Hao Weng,1–3 Cheng-Chia Lee,1–3 Dan-Tzu Lin-Tan,1–3 Kuan-Hsing Chen,1–3 Tzung-Hai Yen,1–3 Wen-Hung Huang1–3 1Department of Nephrology, Division of Clinical Toxicology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China; 2Department of Nephrology, Division of Clinical Toxicology, Linkou Medical Center, Taoyuan, Taiwan, Republic of China; 3Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan, Republic of China Background: The National Kidney Foundation–Kidney Disease Outcomes Quality Initiative recommends that the serum aluminum level (SAL should be below 20 µg/L for patients with maintenance hemodialysis (MHD. However, serum aluminum may have toxic effects on MHD patients even when it is in the apparently acceptable range (below 20 µg/L.Methods: The Medical Ethics Committee approved this study. Initially, 954 MHD patients in dialysis centers were recruited. A total of 901 patients met the inclusion criteria and were followed-up for 1 year. Patients were stratified by SAL into four equal-sized groups: first quartile (<6 µg/L, second quartile (6–9 µg/L, third quartile (9–13 µg/L, and fourth quartile (>13 µg/L. Demographic, biochemical, and dialysis-related data were obtained for analyses. A linear regression model was applied to identify factors associated with SAL. Cox proportional hazard model was used to determine the significance of variables in prediction of mortality.Results: Only 9.3% of MHD patients had SALs of 20 µg/L or more. At the end of the follow-up, 54 patients (6% died, and the main cause of death was cardiovascular disease. Kaplan–Meier survival analysis showed that patients in the fourth SAL quartile had higher mortality than those in the first SAL quartile (log rank test, χ2=13.47, P=0.004. Using the first quartile as reference, Cox multivariate analysis indicated that patients in the third quartile (hazard ratio =1.31, 95% confidence

The Efect of Probiotic Lactobacilli and Alginite on the Cellular Immune Response in Salmonella Infected Mice

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Hlubeňová K.

2017-06-01

Full Text Available Alginite is organic matter rich in humic substances and commonly found in nature, but despite that, the knowledge of its biological effects is limited. In our study we focused on monitoring the effects of alginite alone, as well as its effect as a carrier of probiotic lactobacilli on the cellular immune response in SPF mice after infection with Salmonella Typhimurium. Sixty six conventional SPF female mice of the Balb/c line were divided into 4 groups: 1. infection free negative control (NK supplied neither alginite nor probiotic lactobacilli in the feed; 2. infection free alginite control (Alg supplied feed with 10 % alginite; infected control supplied alginite in the feed but no lactobacilli; 3. infectious control (Alg + Sal - animals infected with salmonella and supplied 10 % alginite in the feed but no lactobacilli;and 4. probiotic group (Lab + Alg + Sal - animals infected with salmonella and administered 10 % alginite and Lactobacillus reuteri 2/6 in the feed. On day 21 of the experiments, the mice were bled and their mesenteric lymph nodes were taken after their death. The peripheral blood of the mice was analysed for the activity of phagocytes and the percentage of selected lymphocyte subpopulations was determined in the mesenteric lymph nodes and blood. The significantly highest phagocytic activity (FA was noted in the infected group with alginite (Alg + Sal. The FA was significantly increased in groups Alg and Lab + Alg + Sal in comparison with the NK group. The highest engulfing ability of phagocytes (phagocytic index was observed in the Lab + Alg + Sal group in comparison with other groups, but also in Alg group in comparison with NK. In the Lab + Alg + Sal group, we observed a significantly higher percentage of B-lymphocytes, CD4+CD8+ and natural killer T cells (NKT, but more significant impact on the numbers of subpopulations of lymphocytes was observed in the mesenteric lymph nodes, with the significantly highest proportions of CD4

CX3CR1 is a modifying gene of survival and progression in amyotrophic lateral sclerosis.

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Alan Lopez-Lopez

Full Text Available The objective of this study was to investigate the association of functional variants of the human CX3CR1 gene (Fractalkine receptor with the risk of Amyotrophic Lateral Sclerosis (ALS, the survival and the progression rate of the disease symptoms in a Spanish ALS cohort. 187 ALS patients (142 sporadic [sALS] and 45 familial and 378 controls were recruited. We investigated CX3CR1 V249I (rs3732379 and T280M (rs3732378 genotypes and their haplotypes as predictors of survival, the progression rate of the symptoms (as measured by ALSFRS-R and FVC decline and the risk of suffering ALS disease. The results indicated that sALS patients with CX3CR1 249I/I or 249V/I genotypes presented a shorter survival time (42.27 ± 4.90 than patients with 249V/V genotype (67.65 ± 7.42; diff -25.49 months 95%CI [-42.79,-8.18]; p = 0.004; adj-p = 0.018. The survival time was shorter in sALS patients with spinal topography and CX3CR1 249I alleles (diff =  -29.78 months; 95%CI [-49.42,-10.14]; p = 0.003. The same effects were also observed in the spinal sALS patients with 249I-280M haplotype (diff =  -27.02 months; 95%CI [-49.57, -4.48]; p = 0.019. In the sALS group, the CX3CR1 249I variant was associated with a faster progression of the disease symptoms (OR = 2.58; 95IC% [1.32, 5.07]; p = 0.006; adj-p = 0.027. There was no evidence for association of these two CX3CR1 variants with ALS disease risk. The association evidenced herein is clinically relevant and indicates that CX3CR1 could be a disease-modifying gene in sALS. The progression rate of the disease's symptoms and the survival time is affected in patients with one or two copies of the CX3CR1 249I allele. The CX3CR1 is the most potent ALS survival genetic factor reported to date. These results reinforce the role of the immune system in ALS pathogenesis.

30-year lidar observations of the stratospheric aerosol layer state over Tomsk (Western Siberia, Russia)

Science.gov (United States)

Zuev, Vladimir V.; Burlakov, Vladimir D.; Nevzorov, Aleksei V.; Pravdin, Vladimir L.; Savelieva, Ekaterina S.; Gerasimov, Vladislav V.

2017-02-01

There are only four lidar stations in the world which have almost continuously performed observations of the stratospheric aerosol layer (SAL) state over the last 30 years. The longest time series of the SAL lidar measurements have been accumulated at the Mauna Loa Observatory (Hawaii) since 1973, the NASA Langley Research Center (Hampton, Virginia) since 1974, and Garmisch-Partenkirchen (Germany) since 1976. The fourth lidar station we present started to perform routine observations of the SAL parameters in Tomsk (56.48° N, 85.05° E, Western Siberia, Russia) in 1986. In this paper, we mainly focus on and discuss the stratospheric background period from 2000 to 2005 and the causes of the SAL perturbations over Tomsk in the 2006-2015 period. During the last decade, volcanic aerosol plumes from tropical Mt. Manam, Soufrière Hills, Rabaul, Merapi, Nabro, and Kelut and extratropical (northern) Mt. Okmok, Kasatochi, Redoubt, Sarychev Peak, Eyjafjallajökull, and Grímsvötn were detected in the stratosphere over Tomsk. When it was possible, we used the NOAA HYSPLIT trajectory model to assign aerosol layers observed over Tomsk to the corresponding volcanic eruptions. The trajectory analysis highlighted some surprising results. For example, in the cases of the Okmok, Kasatochi, and Eyjafjallajökull eruptions, the HYSPLIT air mass backward trajectories, started from altitudes of aerosol layers detected over Tomsk with a lidar, passed over these volcanoes on their eruption days at altitudes higher than the maximum plume altitudes given by the Smithsonian Institution Global Volcanism Program. An explanation of these facts is suggested. The role of both tropical and northern volcanic eruptions in volcanogenic aerosol loading of the midlatitude stratosphere is also discussed. In addition to volcanoes, we considered other possible causes of the SAL perturbations over Tomsk, i.e., the polar stratospheric cloud (PSC) events and smoke plumes from strong forest fires. At least

Evaluation of a Salmonella vectored vaccine expressing Mycobacterium avium subsp. paratuberculosis antigens against challenge in a goat model.

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Syed M Faisal

Full Text Available Johnes disease (JD, caused by Mycobacterium avium subsp paratuberculosis (MAP, occurs worldwide as chronic granulomatous enteritis of domestic and wild ruminants. To develop a cost effective vaccine, in a previous study we constructed an attenuated Salmonella strain that expressed a fusion product made up of partial fragments of MAP antigens (Ag85A, Ag85B and SOD that imparted protection against challenge in a mouse model. In the current study we evaluated the differential immune response and protective efficacy of the Sal-Ag vaccine against challenge in a goat model as compared to the live attenuated vaccine MAP316F. PBMCs from goats vaccinated with Sal-Ag and challenged with MAP generated significantly lower levels of IFN-γ, following in vitro stimulation with either Antigen-mix or PPD jhonin, than PBMC from MAP316F vaccinated animals. Flow cytometric analysis showed the increase in IFN-γ correlated with a significantly higher level of proliferation of CD4, CD8 and γδT cells and an increased expression of CD25 and CD45R0 in MAP316F vaccinated animals as compared to control animals. Evaluation of a range of cytokines involved in Th1, Th2, Treg, and Th17 immune responses by quantitative PCR showed low levels of expression of Th1 (IFN-γ, IL-2, IL-12 and proinflammatory cytokines (IL-6, IL-8, IL-18, TNF-α in the Sal-Ag immunized group. Significant levels of Th2 and anti-inflammatory cytokines transcripts (IL-4, IL-10, IL-13, TGF-β were expressed but their level was low and with a pattern similar to the control group. Over all, Sal-Ag vaccine imparted partial protection that limited colonization in tissues of some animals upon challenge with wild type MAP but not to the level achieved with MAP316F. In conclusion, the data indicates that Sal-Ag vaccine induced only a low level of protective immunity that failed to limit the colonization of MAP in infected animals. Hence the Sal-Ag vaccine needs further refinement to increase its efficacy.

Size-controlled synthesis of gold bipyramids using an aqueous mixture of CTAC and salicylate anions as the soft template.

Science.gov (United States)

Yoo, Hyojong; Jang, Min Hoon

2013-08-07

One-dimensional (1D) gold (Au) bipyramids are successfully synthesized through a facile seed-mediated method using cetyltrimethylammonium chloride (CTAC), Au seed nanoparticles, Ag(+) ions, and ascorbic acid. The length and optical properties of the synthesized Au bipyramids are controlled with precision by varying the amount of salicylate anions (Sal(-)) added during the synthesis. The micelles formed from CTA(+)-Sal(-) mixtures in aqueous solutions act as effective templates for the size-controlled synthesis of 1D nanocrystals.

Berkeley Lab's Saul Perlmutter wins Nobel Prize in Physics | Berkeley Lab

Science.gov (United States)

astrophysics, dark energy, physics Connect twitter instagram LinkedIn facebook youtube This form needs + Materials Sciences twitter instagram LinkedIn facebook youtube A U.S. Department of Energy National twitter instagram LinkedIn facebook youtube

Quantum perceptron over a field and neural network architecture selection in a quantum computer.

Science.gov (United States)

da Silva, Adenilton José; Ludermir, Teresa Bernarda; de Oliveira, Wilson Rosa

2016-04-01

In this work, we propose a quantum neural network named quantum perceptron over a field (QPF). Quantum computers are not yet a reality and the models and algorithms proposed in this work cannot be simulated in actual (or classical) computers. QPF is a direct generalization of a classical perceptron and solves some drawbacks found in previous models of quantum perceptrons. We also present a learning algorithm named Superposition based Architecture Learning algorithm (SAL) that optimizes the neural network weights and architectures. SAL searches for the best architecture in a finite set of neural network architectures with linear time over the number of patterns in the training set. SAL is the first learning algorithm to determine neural network architectures in polynomial time. This speedup is obtained by the use of quantum parallelism and a non-linear quantum operator. Copyright © 2016 Elsevier Ltd. All rights reserved.

Is erythropoietin gene a modifier factor in amyotrophic lateral sclerosis?

Science.gov (United States)

Ghezzi, Serena; Del Bo, Roberto; Scarlato, Marina; Nardini, Martina; Carlesi, Cecilia; Prelle, Alessandro; Corti, Stefania; Mancuso, Michelangelo; Briani, Chiara; Siciliano, Gabriele; Murri, Luigi; Bresolin, Nereo; Comi, Giacomo Pietro

2009-05-01

To investigate the role of erythropoietin (EPO) as genetic determinant in the susceptibility to sporadic amyotrophic lateral sclerosis (SALS). We sequenced a 259-bp region spanning the 3'hypoxia-responsive element of the EPO gene in 222 Italian SALS patients and 204 healthy subjects, matched for age and ethnic origin. No potentially causative variation was detected in SALS subjects; in addition, two polymorphic variants (namely C3434T and G3544T) showed the same genotype and haplotype frequencies in patients and controls. Conversely, a weak but significant association between G3544T and age of disease onset was observed (p=0.04). Overall, our data argue against the hypothesis of EPO as a genetic risk factor for motor neuron dysfunction, at least in Italian population. However, further studies on larger cohort of patients are needed to confirm the evidence of EPO gene as modifier factor.

KARBON MUHASEBESİ

OpenAIRE

DUMAN, Haluk; ÖZPEYNİRCİ, Rabia; YÜCENURŞEN, Mehmet; BAĞCI, Haşim

2012-01-01

Bu çalışmanın amacı karbon salınımı ve karbon ticaretinin muhasebeye aktarılmasıdır. Karbon salınımı ve ticareti; “bir alıcının karbon azaltımına yönelik taahhüt ettiği hedeflerini yerine getirmede kullanacağı ve belli bir miktarda karbon salınımı indirimi yapma hakkını ifade eden “krediler” karşılığında, başka bir tarafa ödeme yapması ile ortaya çıkan alım sözleşmeleri” olarak tanımlanmaktadır (Tunahan, 2010). Çevre muhasebesi anlayışı çevreye muhasebe açısından bakan bir yaklaşım sonucu ort...

ANXA11 mutations prevail in Chinese ALS patients with and without cognitive dementia.

Science.gov (United States)

Zhang, Kang; Liu, Qing; Liu, Keqiang; Shen, Dongchao; Tai, Hongfei; Shu, Shi; Ding, Qingyun; Fu, Hanhui; Liu, Shuangwu; Wang, Zhili; Li, Xiaoguang; Liu, Mingsheng; Zhang, Xue; Cui, Liying

2018-06-01

To investigate the genetic contribution of ANXA11 , a gene associated with amyotrophic lateral sclerosis (ALS), in Chinese ALS patients with and without cognitive dementia. Sequencing all the coding exons of ANXA11 and intron-exon boundaries in 18 familial amyotrophic lateral sclerosis (FALS), 353 unrelated sporadic amyotrophic lateral sclerosis (SALS), and 12 Chinese patients with ALS-frontotemporal lobar dementia (ALS-FTD). The transcripts in peripheral blood generated from a splicing mutation were examined by reverse transcriptase PCR. We identified 6 nonsynonymous heterozygous mutations (5 novel and 1 recurrent), 1 splice site mutation, and 1 deletion of 10 amino acids (not accounted in the mutant frequency) in 11 unrelated patients, accounting for a mutant frequency of 5.6% (1/18) in FALS, 2.3% (8/353) in SALS, and 8.3% (1/12) in ALS-FTD. The deletion of 10 amino acids was detected in 1 clinically undetermined male with an ALS family history who had atrophy in hand muscles and myotonic discharges revealed by EMG. The novel p. P36R mutation was identified in 1 FALS index, 1 patient with SALS, and 1 ALS-FTD. The splicing mutation (c.174-2A>G) caused in-frame skipping of the entire exon 6. The rest missense mutations including p.D40G, p.V128M, p.S229R, p.R302C and p.G491R were found in 6 unrelated patients with SALS. The ANXA11 gene is one of the most frequently mutated genes in Chinese patients with SALS. A canonical splice site mutation leading to skipping of the entire exon 6 further supports the loss-of-function mechanism. In addition, the study findings further expand the ANXA11 phenotype, first highlighting its pathogenic role in ALS-FTD.

A consumer perspective of advertising by attorneys

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C. Boshoff

1991-06-01

Full Text Available Attorneys in South Africa may soon be permitted to advertise their services for the first time. This recommendation put forward by the Association of Law Societies, though still to be ratified by the four provincial law societies, has come amid increasing competition between attorneys and non- professionals. The marketing fraternity is, however, uncertain as to how members of the public are likely to react to legal services advertising. This study attempts to provide some tentative guidelines for decision-making on advertising by attorneys. Interested parties like attorneys, marketing consultants, and advertising agencies could use the researched information to structure marketing communication strategies which will not transgress the ethical code of the attorneys' profession, but which will satisfy the information needs of consumers. The study reports the findings of a survey conducted among 1 000 members of the public. Indications are that consumers not only think that advertising should be permitted, but also that it will benefit both themselves and the legal profession. Opsomming Prokureurs mag moontlik binnekort toegelaat word om hul dienste te adverteer. Die aanbeveling van die Vereniging van Prokureursordes, wat nog deur die vier provinsiale wetsgenootskappe bekragtig moet word, is geneem as gevolg van toenemende mededinging tussen prokureurs en nie-professionele praktisyns. Bemarkingsdeskundiges is egter onseker oor wat die publiek se reaksie sal wees. Die studie poog om enkele tentatiewe riglyne voor te stel vir bemarkingskommunikasiestrategieë wat nie die regsprofessie se etiese kode sal oortree nie, maar tog voldoende inligting aan verbruikers sal beskikbaar stel. Die bevindinge van 'n opname onder 1 000 lede van die publiek dui daarop dat reklame nie alleen verwelkom sal word nie, maar dat dit moontlik tot voordeel van sowel die publiek as die regsprofessie sal strek.

Estado Nutricional del Yodo.

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Hernando Vargas Uricoechea

2015-06-01

Full Text Available INTRODUCCIÓN: Los Desórdenes por Deficiencia de Yodo son un problema serio de salud pública, con cerca de 2 mil millones de personas a riesgo de padecerlos, pudiendo causar bocio neonatal, cretinismo, retardo mental, hipotiroidismo, entre otros. Estos desórdenes son aún prevalentes, y en algunos casos los esfuerzos para su erradicación se han traducido en aumento del riesgo de exceso poblacional de yodo y autoinmunidad tiroidea. En Colombia, se desconoce el estado real de yodo en la población. OBJETIVOS: Determinar la mediana de la yoduría en población escolar, y de los hábitos del consumo de sal, función y parámetros de autoinmunidad tiroidea, y cociente intelectual. MATERIALES Y MÉTODOS: Estudio basado en la comunidad, de corte transversal. Se evaluaron las variables sociodemográficas, la frecuencia de bocio y los niveles de TSH, anti-TPO, anti-Tg, anti-TSHR, yoduria, test de factor G de Cattell, y hábitos del consumo de sal. RESULTADOS: El consumo de sal promedio persona/día fue de 18,13 g. El 37,9% presentó bocio. 36,1% tenían un valor límite en el cociente intelectual. La mediana de yoduria fue de 510,3 μg/L. El 42,75% tuvo anti-TPO positivos, y el 2,87% anti-Tg positivos. El 10% presentó niveles de TSH elevados. CONCLUSIÓN: En escolares de zona urbana, hay un exceso en la mediana de yoduria, pudiendo explicarse por el alto consumo de sal. La alta prevalencia de autoinmunidad tiroidea y bocio, junto al alto nivel de la TSH, puede ser consecuencia del exceso en la ingesta de sal y de otros factores medioambientales/ hereditarios.

H1-histamine receptors in the amygdala are involved in emotional memory but do not mediate anxiety-related behaviors in mice submitted to EPM testing.

Science.gov (United States)

Serafim, K R; Gianlorenço, A C L; Daher, F P; Mattioli, R

2012-10-01

This study investigated the role of amygdala H(1) receptors in state-dependent memory deficits induced by l-histidine (LH). Tests using an elevated plus-maze (EPM) were performed on two consecutive days: Trial 1 (T1) and Trial 2 (T2). Before each trial, mice were intraperitoneally (IP) injected with LH (500mg/kg). Two hours later, they were microinjected with the H(1) receptor antagonist, chlorpheniramine (CPA 0.016, 0.052, or 0.16 nmol/0.1μl), or saline (SAL) into the amygdala and submitted to the EPM. LH-CPA did not affect trial 1 performances in the EPM, which indicated that these drugs did not affect anxiety. Emotional memory, as revealed by a reduction in open arm exploration between both trials, was present in the SAL-SAL groups as well as in the SAL-CPA groups for the lower doses of CPA (0.016 and 0.052nmol). On the contrary, neither the LH-SAL group nor the LH-CPA groups exhibited this decrease in open arm activity between both trials, which reveals that LH impaired emotional memory. While intra-amygdalar CPA did not interact with LH effect, it impaired per se the emotional memory performances at the highest dose (0.16nmol). No significant changes were observed in the number of enclosed arm entries (EAE), an EPM index of general exploratory activity. These results may be attributed to a combined effect in the different nucleus of the amygdala. Taken together, these results suggest that the H(1) receptors in the amygdala are not implicated in anxiety-like behaviors but are involved in emotional states induced by the T1/T2 EPM protocol in mice. Copyright © 2012 Elsevier Inc. All rights reserved.

A IMPORTÂNCIA DO PLANO DE CARGOS E SALÁRIO EM UMA EMPRESA NO SEGMENTO DE MOVEÍS E ELETRODOMÉSTICOS LTDA NA CIDADE DE QUIXADÁ-CE

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Naria de Oliveira Silva

2014-06-01

Full Text Available O plano de cargos e salários para melhor ter entendimento faz-se necessário ter conhecimento sobre remunerações, benefícios, motivação. Para as pessoas interagirem de acordo com os interesses da organização é importante que estejam satisfeitos e motivados. Uma vez satisfeitos, o trabalho será desenvolvido com eficiência, agilidade. O plano de cargos e salários é importante porque cada ocupante do cargo procura desempenhar suas tarefas de forma produtiva e responsável para que suas competências sejam reconhecidas e compensadas de forma favorável e justa. No presente trabalho verificou-se de que forma o processo de cargos e salário é aplicado e reconhecido pelos funcionários da empresa, o que foi realizado inicialmente através de um embasamento teórico que permitiu trazer a luz os conhecimentos necessários para compreensão da análise dos dados e resultados obtidos. Para o desenvolvimento deste trabalho utilizou-se a pesquisa descritiva com abordagem qualitativa. Como resultado, todos os entrevistados mostraram-se satisfeitos com os cargos e salários atribuídos aos mesmos além de Satisfação quanto à infraestrutura da empresa; Todos pretendem permanecer por longo período de tempo trabalhando na mesma, os participantes relataram satisfação com a empresa em relação ao trabalho prestado além de afirmarem que a empresa se interessa pelo crescimento profissional de seus funcionários. Podemos concluir que o funcionamento dos cargos e salário, ao longo dos anos, tem proporcionado não apenas a sobrevivência da empresa, bem como seu crescimento e solidificação dentro do mercado em que atua.

Long acting β2-agonist and corticosteroid restore airway glandular cell function altered by bacterial supernatant

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Nawrocki-Raby Béatrice

2010-01-01

Full Text Available Abstract Background Staphylococcus aureus releases virulence factors (VF that may impair the innate protective functions of airway cells. The aim of this study was to determine whether a long-acting β2 adrenergic receptor agonist (salmeterol hydroxynaphthoate, Sal combined with a corticosteroid (fluticasone propionate, FP was able to regulate ion content and cytokine expression by airway glandular cells after exposure to S. aureus supernatant. Methods A human airway glandular cell line was incubated with S. aureus supernatant for 1 h and then treated with the combination Sal/FP for 4 h. The expression of actin and CFTR proteins was analyzed by immunofluorescence. Videomicroscopy was used to evaluate chloride secretion and X-ray microanalysis to measure the intracellular ion and water content. The pro-inflammatory cytokine expression was assessed by RT-PCR and ELISA. Results When the cells were incubated with S. aureus supernatant and then with Sal/FP, the cellular localisation of CFTR was apical compared to the cytoplasmic localisation in cells incubated with S. aureus supernatant alone. The incubation of airway epithelial cells with S. aureus supernatant reduced by 66% the chloride efflux that was fully restored by Sal/FP treatment. We also observed that Sal/FP treatment induced the restoration of ion (Cl and S and water content within the intracellular secretory granules of airway glandular cells and reduced the bacterial supernatant-dependent increase of pro-inflammatory cytokines IL8 and TNFα. Conclusions Our results demonstrate that treatment with the combination of a corticosteroid and a long-acting β2 adrenergic receptor agonist after bacterial infection restores the airway glandular cell function. Abnormal mucus induced by defective ion transport during pulmonary infection could benefit from treatment with a combination of β2 adrenergic receptor agonist and glucocorticoid.

Spectroscopic studies of the intramolecular hydrogen bonding in o-hydroxy Schiff bases, derived from diaminomaleonitrile, and their deprotonation reaction products

Science.gov (United States)

Szady-Chełmieniecka, Anna; Kołodziej, Beata; Morawiak, Maja; Kamieński, Bohdan; Schilf, Wojciech

2018-01-01

The structural study of five Schiff bases derived from diaminomaleonitrile (DAMN) and 2-hydroxy carbonyl compounds was performed using 1H, 13C and 15N NMR methods in solution and in the solid state as well. ATR-FTIR and X-Ray spectroscopies were used for confirmation of the results obtained by NMR method. The imine obtained from DAMN and benzaldehyde was synthesized as a model compound which lacks intramolecular hydrogen bond. Deprotonation of all synthesized compounds was done by treating with tetramethylguanidine (TMG). NMR data revealed that salicylidene Schiff bases in DMSO solution exist as OH forms without intramolecular hydrogen bonds and independent on the substituents in aromatic ring. In the case of 2-hydroxy naphthyl derivative, the OH proton is engaged into weak intramolecular hydrogen bond. Two of imines (salDAMN and 5-BrsalDAMN) exist in DMSO solution as equilibrium mixtures of two isomers (A and B). The structures of equilibrium mixture in the solid state have been studied by NMR, ATR-FTIR and X-Ray methods. The deprotonation of three studied compounds (salDAMN, 5-BrsalDAMN, and 5-CH3salDAMN) proceeded in two different ways: deprotonation of oxygen atom (X form) or of nitrogen atom of free primary amine group of DAMN moiety (Y form). For 5-NO2salDAMN and naphDAMN only one form (X) was observed.

Statistical design of mass spectrometry calibration procedures

International Nuclear Information System (INIS)

Bayne, C.K.

1996-11-01

The main objective of this task was to agree on calibration procedures to estimate the system parameters (i.e., dead-time correction, ion-counting conversion efficiency, and detector efficiency factors) for SAL's new Finnigan MAT-262 mass spectrometer. SAL will use this mass spectrometer in a clean-laboratory which was opened in December 1995 to measure uranium and plutonium isotopes on environmental samples. The Finnigan MAT-262 mass spectrometer has a multi-detector system with seven Faraday cup detectors and one ion- counter for the measurement of very small signals (e.g. 10 -17 Ampere range). ORNL has made preliminary estimates of the system parameters based on SAL's experimental data measured in late 1994 when the Finnigan instrument was relatively new. SAL generated additional data in 1995 to verify the calibration procedures for estimating the dead-time correction factor, the ion-counting conversion factor and the Faraday cup detector efficiency factors. The system parameters estimated on the present data will have to be reestablished when the Finnigan MAT-262 is moved-to the new clean- laboratory. Different methods will be used to analyzed environmental samples than the current measurement methods being used. For example, the environmental samples will be electroplated on a single filament rather than using the current two filament system. An outline of the calibration standard operating procedure (SOP) is included

Uranium extraction from ores with salicylic acid; I - uranium extraction from input phosphate ore of Abu Zaabal phosphate plant, Egypt

International Nuclear Information System (INIS)

Hussein, E.M.

1997-01-01

Salicylic acid has been tested (for environmental importance) to extract U from input phosphate ore of Abu-Zaabal phosphate plant, Egypt prior to its processing for production of phosphatic fertilizers. Uranyl ion forms with this acid three stable complexes; namely [UO 2 Sal] degree, [U O 2 SaL 2 ] 2- and UO 2 SaL-3] 4- depending on the total uranyl and salicylic acid concentrations and their ratios. Study of relevant extraction factors revealed however that, the extraction process is controlled by the amount of salicylic acid used, alcohol/aqueous ratio, solid/liquid ratio and time of agitation. The obtained results showed that uranium is selectively leached by the application of such a leaching reagent. In order to recover U from the obtained pregnant leach liquor, the latter is adjusted by ammonia to PH 5-6.5, where the crystalline pp t of N H 4 [UO 2 SaL 3 ] 4 H 2 O has formed. This precipitation has been carried out after concentrating the obtained pregnant leach liquor by its recycle for U extraction from new ore batches. The precipitated ammonium uranyl tri salicylate is calcined at 500 degree C for obtaining pure orange yellow trioxide (UO 3 ) powder. On the basis of one ton ore treatment, an economic flowsheet for U recover y from the study ore material has been suggested

Influence of Moisture Content and Compression Axis on Physico-mechanical Properties of Shorea robusta Seeds

Science.gov (United States)

Shashikumar, C.; Pradhan, R. C.; Mishra, S.

2018-02-01

Shorea robusta (Sal) is mainly harvested and processed for its seed oil, which has diverse application in commercial food and non-food based industries. Before extraction of its oil, seeds undergo into various post-harvest unit operations. Physical and mechanical properties play an important role in the handling and other processing activity. In this study influence of moisture content and compression axis of sal seed on physico-mechanical properties were studied and their application are highlighted. The experiments were conducted at five different moisture levels of 6.38, 10.49, 13.63, 17.64, and 21.95% (d.b) at two different orientations. The first orientation is on major axis (LEN) of the seed, and the other orientation is on intermediate or minor axis (WID), which is right angle to the major axis. It was observed that 68% of sal seeds were of medium size group at initial moisture content of 10.49% (d.b). The mean length and width of sal seed was found to be 26.7 mm and 12.8 mm, respectively. It was found that values of hardness, deformation at hardness, deformation at hardness percentage and energy for rupture were higher in minor axis (WID) as compared to the major axis (LEN). The results provide necessary data that may be useful to engineers, scientists, industries in the design of a suitable post-harvest processing machine.

Influence of Moisture Content and Compression Axis on Physico-mechanical Properties of Shorea robusta Seeds

Science.gov (United States)

Shashikumar, C.; Pradhan, R. C.; Mishra, S.

2018-06-01

Shorea robusta (Sal) is mainly harvested and processed for its seed oil, which has diverse application in commercial food and non-food based industries. Before extraction of its oil, seeds undergo into various post-harvest unit operations. Physical and mechanical properties play an important role in the handling and other processing activity. In this study influence of moisture content and compression axis of sal seed on physico-mechanical properties were studied and their application are highlighted. The experiments were conducted at five different moisture levels of 6.38, 10.49, 13.63, 17.64, and 21.95% (d.b) at two different orientations. The first orientation is on major axis (LEN) of the seed, and the other orientation is on intermediate or minor axis (WID), which is right angle to the major axis. It was observed that 68% of sal seeds were of medium size group at initial moisture content of 10.49% (d.b). The mean length and width of sal seed was found to be 26.7 mm and 12.8 mm, respectively. It was found that values of hardness, deformation at hardness, deformation at hardness percentage and energy for rupture were higher in minor axis (WID) as compared to the major axis (LEN). The results provide necessary data that may be useful to engineers, scientists, industries in the design of a suitable post-harvest processing machine.

Summer Arctic sea ice albedo in CMIP5 models

OpenAIRE

Koenigk, T.; Devasthale, A.; Karlsson, K.-G.

2014-01-01

Spatial and temporal variations of summer sea ice albedo over the Arctic are analyzed using an ensemble of historical CMIP5 model simulations. The results are compared to the CLARA-SAL product that is based on long-term satellite observations. The summer sea ice albedo varies substantially among CMIP5 models, and many models show large biases compared to the CLARA-SAL product. Single summer months show an extreme spread of ice albedo among models; July values vary between 0....

Outcome of sporadic amyotrophic lateral sclerosis treated With non-invasive ventilation and riluzole Sobrevida en pacientes con esclerosis lateral amiotrófica esporádica tratados con ventilación no invasiva y riluzole

OpenAIRE

Martín Sívori; Gabriel E. Rodríguez; Daniel Pascansky; César Séenz; Roberto E. P. Sica

2007-01-01

Sporadic amyotrophic lateral sclerosis (sALS) is a progressive degenerative motor neuron disorder lacking specific treatment. Riluzole is the only drug able to modestly slow down the course of the disease. Respiratory insufficiency is the main cause of death; non invasive ventilation (NIV) has shown to improve survival. Our aim was to evaluate the effect of NIV and riluzole on survival. Ninety seven patients with a diagnosis of sALS were assessed and followed up for 60 months. Twenty nine pat...

Análisis de los movimientos del terreno producidos por la excavación mecánica del túnel de la L9 en la zona de Santa Coloma de Gramenet

OpenAIRE

Chamorro Ramos, Olga

2005-01-01

Se observa la construcción de un túnel de 12 m de diámetro excavado con tuneladora en Santa Coloma de Gramanet, Barcelona. El túnel excava un perfil muy irregular de alteración del granito. En sus niveles superiores el grado de alteración llega a ser de IV-V, llamado sauló, del cual se realiza un ensayo triaxial con rotura de tres probetas. Se analizan los conceptos básicos a tener en cuenta en el diseño de un túnel con tuneladora. Se revisan los diferentes métodos existentes para predecir as...

Something important is missing from PRA

International Nuclear Information System (INIS)

Ward, D.A.

1991-01-01

This paper provides some views on priorities and directions for the future or risk management. There are some problems with the priorities and directions that now seem dominant. Norm Rasmussen of MIT and the late Saul Levine, who was then with the U.S. Atomic Energy Commission (AEC) (the NRC's predecessor), and their colleagues deserve much credit for the invention of the art of Probabilistic Risk Assessment. Certainly the elements of risk analysis were well known and used, at least implicitly, in much of engineering and technology. But, WASH-1400, The Reactor Safety Study issued in 1975, put these elements together in a comprehensive and courageously rational way

Epidemiology of amyotrophic lateral sclerosis patients in a centre in Buenos Aires

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Mariela Bettini

2011-12-01

Full Text Available Sporadic amyotrophic lateral sclerosis (sALS is considered a multifactorial disease with genetic and environmental factors causing motor neuron degeneration. OBJECTIVE: To describe the epidemiological and occupational characteristics of patients with sALS who attended the Ramos Mejía Hospital at Buenos Aires, Argentina. METHOD: We analyzed the medical records of sALS patients diagnosed between 2001 and 2008. All occupations were coded according to the International Standard Classification of Occupation (ISCO. RESULTS: 187 patients were assessed, 38.5% were women and 61.5% men. Mean age at diagnosis was 55 years. 16% of them came from rural areas; 68% of the studied population had no health insurance. 40% were employed in elementary occupations, 19 were technicians and 8 handicraftsmen. CONCLUSION: The most represented profession was elementary occupation. A large proportion of patients came from rural areas, which might suggest an increased risk of environmental exposure to an unknown agent in those regions.

(Prérif Central, Maroc septentrional

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Abdelghani Gartet

2006-01-01

Full Text Available El diapiro de sal de Tissa, situado en el Prerif central marroquí, afl ora en una zona de contacto estructural anormal donde la morfogénesis kárstica es muy activa. La solubilidad de las formaciones del complejo triásico es excesivamente fuerte. El macizo yesífero-salino representa un yacimiento de sal gema casi inagotable. Sin embargo, las aguas de Oued Lebène, en época de crecidas, socavan intensamente la base del macizo y terminan siendo afectadas por la contaminación química. La explotación de la cantera de sal, siendo tradicional, plantea numerosos problemas de planifi cación, a la vez que atenta severamente contra el medio ambiente (natural y urbano y contra la sociedad humana. Las medidas de defensa del medio ambiente adoptadas al respecto resultan por el momento insufi cientes dada la falta de una legislación práctica y rigurosa.

Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride

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Yusif Rehab Mohammad

2014-03-01

Full Text Available Eudragit E (EE-sodium alginate (SA polyelectrolyte complexes (PECs were prepared at pH 4 and 5.8 using sodium alginate of high (SAH and low viscosity (SAL. The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy (FT-IR and differential scanning calorimetry (DSC. Diltiazem hydrochloride (DTZ HCl tablets were prepared using the prepared EE-SA PECs and their physical mixtures at different ratios as matrices. Tablets were evaluated for swelling characteristics and in vitro drug release. Tablets containing EE-SAH physical mixtures of ratios (1.5:1 and 1:3 as matrices were effective in achieving sustained release of DTZ HCl, where the percent drug released was significantly (p < 0.05 decreased compared to that from tablets either containing the same ratios of EE-SAL physical mixtures or the preformed EE- -SAH and EE-SAL PECs.

Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis.

Science.gov (United States)

Coppedè, Fabio; Lo Gerfo, Annalisa; Carlesi, Cecilia; Piazza, Selina; Mancuso, Michelangelo; Pasquali, Livia; Murri, Luigi; Migliore, Lucia; Siciliano, Gabriele

2010-02-01

Impairments in DNA repair enzymes have been observed in amyotrophic lateral sclerosis (ALS) tissues, particularly in the activity of the apurinic/apyrimidinic endonuclease 1 (APEX1). Moreover, it was suggested that the common APEX1 Asp148Glu polymorphism might be associated with ALS risk. To further address this question we performed the present study aimed at evaluating the contribution of the APEX1 Asp148Glu polymorphism in sporadic ALS (sALS) risk and clinical presentation, including age and site of onset and disease progression. We screened 134 sALS Italian patients and 129 matched controls for the presence of the APEX1 Asp148Glu polymorphism. No difference in APEX1 Asp148Glu allele and genotype frequencies was found between the groups, nor was the polymorphism associated with age and site of onset or disease progression. Present results do not support a role for the APEX1 Asp148Glu polymorphism in sALS pathogenesis in the Italian population.

Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride.

Science.gov (United States)

Yusif, Rehab Mohammad; Abu Hashim, Irhan Ibrahim; El-Dahan, Marwa Salah

2014-03-01

Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Diltiazem hydrochloride (DTZ HCl) tablets were prepared using the prepared EE-SA PECs and their physical mixtures at different ratios as matrices. Tablets were evaluated for swelling characteristics and in vitro drug release. Tablets containing EE-SAH physical mixtures of ratios (1.5:1 and 1:3) as matrices were effective in achieving sustained release of DTZ HCl, where the percent drug released was significantly (p < 0.05) decreased compared to that from tablets either containing the same ratios of EE-SAL physical mixtures or the preformed EE- -SAH and EE-SAL PECs.

O mercado de trabalho brasileiro é segmentado? Alterações no perfil da informalidade e nos diferenciais de salários nas décadas de 1980 e 1990

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Andréa Zaitune Curi

2006-12-01

Full Text Available Neste artigo examinamos o comportamento do mercado de trabalho formal e informal no Brasil nas últimas duas décadas, utilizando dados longitudinais da Pesquisa Mensal de Emprego para 6 regiões metropolitanas no Brasil. Os resultados mostram que a redução da formalidade no Brasil decorreu, principalmente, do aumento das transições do setor formal para o informal e devido à redução da taxa de saída do desemprego para o setor formal, que ocorreu principalmente entre os mais escolarizados vivendo na região metropolitana de São Paulo e que estavam desempregados há mais de três meses. Além disto, os resultados mostram que a rotatividade entre o setor informal e formal é bastante elevada e que a probabilidade de saída do desemprego ou do setor informal diminui com o tempo de permanência na situação inicial. O diferencial de salários entre o setor formal e o informal, após o controle pelas características não-observáveis dos trabalhadores, era de apenas 10% na década de 1980 e declinou para cerca de 5% na década de 1990. Isto indica que a segmentação no mercado de trabalho brasileiro é muito baixa, o que o aproxima de um mercado competitivo.In this paper we examine the determinants of the mobility of Brazilian workers from the formal sector to informality, self-employment and unemployment, using longitudinal data from Monthly household surveys for 6 metropolitan regions. The results show that the reduction in formality was due to an increase in the transitions from the formal to the informal sector and to a decline in the exits from unemployment to the formal sector. Moreover, sector turn-over in Brazil is quite high and the transitions from unemployment and from the informal sector are time dependent. Finally, the wage differentials between workers in the formal and in the informal sector, after controlling for workers fixed effects was 10% in the 1980s and declined to about 5% in the 1990s, showing that the Brazilian

Utilização de água salina e condicionador de solo na produção de beterraba no semi-árido brasileiro Effect of saline water and soil conditioner on sugar beet yield in the Brazilian semi-arid region

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Gilberto G. Cordeiro

1999-03-01

Full Text Available O experimento foi conduzido no Campo Experimental da Embrapa Semi-Árido em Petrolina - PE, no primeiro semestre de 1997 com o objetivo de avaliar o efeito de diferentes níveis de salinidade da água de irrigação e do condicionador de solo Sper Sal (ácido polimaléico na produção de beterraba (Beta vulgaris L., cultivar Early Wonder. O delineamento experimental foi de blocos ao acaso com quatro repetições. Os tratamentos foram: água com condutividade elétrica de 0,1 (água do Rio São Francisco - testemunha 4 e 8 dS/m e água com condutividade elétrica 0,1, 4 e 8 dS/m mais Sper Sal, com parcelas de 2 m². Os resultados obtidos mostraram que as produtividades variaram de 20,2 a 65,4 t/ha para os tratamentos irrigados com água salina mais Sper Sal e água do Rio São Francisco, respectivamente. Não se verificou diferença significativa na produtividade quando do uso de água com níveis de salinidade de 4 e 8 dS/m, cujas produtividades foram 29,4 e 26,3 t/ha respectivamente. Nos tratamentos com Sper Sal, observou-se que na concentração salina de 4 dS/m, o condicionador de solo demonstrou ser mais eficiente, em relação à concentração de 8 dS/m.An experiment was carried out at an experimental field in Embrapa Semi-arid, Petrolina - PE, during the first semester of 1997, with the objective of evaluating the effect of different irrigation water salinity levels, with and without the soil conditioner Sper Sal (polymaleic acid, on the yield of sugar beet (Beta vulgaris L., cv. Early Wonder. The experiment was set up in complete randomized block design, with four replications. Six treatments were tested: water with electrical conductivity of 0.1 (control, 4 and 8 dS/m, and the levels of electrical conductivity cited above plus Sper salt. The size of the plots was 2m². The results obtained showed that the yield varied from 20.2 to 65.4 t/ha, respectively, for irrigation treatments of saline with Sper Sal and water from the S�

A natação minimiza o retardo no crescimento somático e ósseo de ratos? Does swimming minimize somatic and bone growth delay in rats?

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Ana Cristina Falcão Esteves

2010-10-01

Full Text Available A formação óssea é regulada por fatores hormonais e modificada por estímulos extrínsecos, como a prática de exercícios. Avaliou-se o efeito da natação sobre o crescimento somático e ósseo de ratas submetidas a dois modelos experimentais a fim de reproduzir déficit hormonal. Utilizou-se 28 ratas Wistar neonatas fêmeas separadas em: grupo Glutamato Monossódico (GluM, n = 14; solução de GM 4.0mg/g, dias alternados, primeiros 14 dias de vida e grupo Salina (Sal, n = 14; solução salina. Peso corpóreo e mensurações murinométricas (eixos laterolateral, anteroposterior do crânio - LLC/APC - e comprimento da cauda - CC foram avaliados do primeiro ao 30º dia de vida. Aos 60 dias, o Grupo GluM foi ovariectomizado (GluMO e o sal apenas passou pelo estresse cirúrgico. Então, metade dos animais de cada grupo iniciou o programa de natação (12 semanas, cinco dias/semanas, 60 min/sessão resultando nos seguintes grupos experimentais: Salina Sedentário (Salsed, n = 7, Salina Natação (Salnat, n = 7, Glutamato Ovariectomia Sedentário (GluMOsed, n = 7 e Glutamato Ovariectomia Natação (GluMOnat, n = 7. Ao final do experimento o fêmur direito foi pesado e seu comprimento avaliado. Nos 30 dias iniciais, GluM reduziu o peso corpóreo e os eixos LLC, APC e CC comparado ao grupo SAL. Aos 60 dias, o peso corpóreo do GLuM permaneceu menor comparado ao SAL e ao final foi similar entre os grupos SALsed e SALnat e, GLuMOsed e GluMOnat. Porém, houve redução no peso do GlutMOsed comparado ao SALsed. A natação favoreceu o peso do fêmur no SAL e não o alterou entre os GluMOsed e GluMOnat, entretanto, houve aumento no grupo SALsed comparado ao GluMOsed. No comprimento, o SALnat foi similar ao SALsed e o mesmo ocorreu entre GluMOnat e GluMOsed. Porém, SALsed apresentou comprimento maior que GluMOsed. A natação não foi capaz de reverter, em animais adultos jovens, os efeitos provocados por situações de desequilíbrio corp

Effects of lidocaine on lipopolysaccharide-induced synovitis in horses

OpenAIRE

Campebell,R.C.; Peiró,J.R.; Valadão,C.A.A.; Santana,A.E.; Cunha,F.Q.

2004-01-01

Lidocaine (100mg 2%) injected into the carpal joint was used to evaluate the inflammatory response induced by injection (1.5ng) of intra-articular E. coli lipopolysaccharide (LPS) endotoxin. Seventeen male Mangalarga horses aged two to three years were divided into three groups and in all animals was injected 0.9% saline (SAL) in the left carpus (LC), and in the right carpus (RC) one of the following combinations were injected: group A (n=6) LPS plus SAL; group B (n=6) LPS plus lidocaine; gro...

Preservación y abundancia de escamas de peces en sedimentos del margen continental de Chile (21-36° S Fish scale preservation and abundance in sediments from the continental margin off Chile (21-36° S

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JAVIER A DÍAZ-OCHOA

2008-12-01

Full Text Available Con el objetivo de evaluar la relación entre la preservación de escamas de peces y las variaciones en las condiciones redox en sedimentos del margen continental de Chile, este trabajo presenta recuentos de escamas de peces y concentraciones normalizadas de elementos redox sensibles (Mo/Al, S/Al, Fe/Al en ocho testigos de sedimento recolectados en la zona de minimo oxígeno frente a Chile (Iquique: 20°15' S, bahía de Mejillones: 23° S y Concepción: 36° S. En el norte de Chile (Iquique y Mejillones predominan las escamas de anchoveta (Engraulis ringens y de peces de la familia Myctophidae (media = 90 y 120 escamas 1.000 cm-3, respectivamente mientras que en Chile centro-sur (Concepción son más abundantes las escamas de jurel (Trachurus murphy; media = 140 escamas 1.000 cm-3. La abundancia de escamas de merluza común (Merluccius gayi gayi y de sardina (Sardinops sagax es aproximadamente un orden de magnitud más baja que la de anchoveta o jurel. En general, los valores más altos y los rangos más amplios de variación en las razones Mo/Al, S/Al y Fe/Al se encuentran en Mejillones (Mo/Al ~0,8-12 mg g-1, S/Al 0,2-4,6 g g-1, Fe/Al 0,3-0,7 g g-1 seguidos por Iquique (Mo/Al -0,2-1,8; S/Al 0,2-0,7, Fe/Al 0,5-0,8, mientras que Concepción revela valores más bajos y poco variables (Mo/Al ~0,07, S/Al ~0,15 y Fe/Al ~0,5. La razón Mo/Al, utilizada como indicador de paleo-oxigenación, permite inferir condiciones reductoras relativamente más intensas en los sedimentos de la Bahía de Mejillones e Iquique que en Concepción. En las tres localidades de muestreo se evidencia una asociación estadísticamente significativa entre la abundancia de escamas de anchoveta y el logaritmo de la razón Mo/Al (r²= 0,46; P 1 mg g-1.The relationship between fish scale preservation and variations in the sediment redox conditions on Chile's continental shelf are evaluated herein through fish scale counts and normalized concentrations of redox sensitive elements

A longitudinal analysis of salivary testosterone concentrations and competitiveness in elite and non-elite women athletes.

Science.gov (United States)

Crewther, Blair T; Cook, Christian J

2018-05-01

There is evidence linking women's testosterone (T) to competitive behaviours in sport and exercise. To advance this work, we examined the longitudinal relationships between salivary T (sal-T) and competitiveness in athletic women who differ in training status. Elite (n = 9) and non-elite (n = 21) women athletes were monitored on days 6-8 (follicular phase), 13-15 (ovulatory phase) and 20-22 (Luteal phase) of a menstrual cycle with two repeats. Salivary T levels were assessed before breakfast, followed by two questions (each rated on a 1-7 scale) on competitive desire and training motivation. Using a linear mixed model, we evaluated the menstrual phase and training status effects on each variable, before assessing the within-subject effects of sal-T on competitiveness. Salivary T concentrations were higher at ovulation (effect size [ES] difference = 0.2-1.4), relative to the follicular and luteal phases, with a more marked response among elite women (p competitiveness ratings showed similar menstrual-phase variation (ES difference = 0.6-1.0 at ovulation). A positive effect of sal-T on competitiveness emerged in both groups (p competitive desire and training motivation all peaked around ovulation in women athletes. Notably, sal-T availability and its relationship with competitiveness was stronger among high-performing athletes. Our findings confirm menstrual fluctuations in T and competitiveness among naturally-cycling women, with population context as a moderating factor. Copyright © 2018 Elsevier Inc. All rights reserved.

Atomic Structure of Salutaridine Reductase from the Opium Poppy (Papaver somniferum)

Energy Technology Data Exchange (ETDEWEB)

Higashi, Yasuhiro; Kutchan, Toni M.; Smith, Thomas J. (Danforth)

2011-11-18

The opium poppy (Papaver somniferum L.) is one of the oldest known medicinal plants. In the biosynthetic pathway for morphine and codeine, salutaridine is reduced to salutaridinol by salutaridine reductase (SalR; EC 1.1.1.248) using NADPH as coenzyme. Here, we report the atomic structure of SalR to a resolution of {approx}1.9 {angstrom} in the presence of NADPH. The core structure is highly homologous to other members of the short chain dehydrogenase/reductase family. The major difference is that the nicotinamide moiety and the substrate-binding pocket are covered by a loop (residues 265-279), on top of which lies a large 'flap'-like domain (residues 105-140). This configuration appears to be a combination of the two common structural themes found in other members of the short chain dehydrogenase/reductase family. Previous modeling studies suggested that substrate inhibition is due to mutually exclusive productive and nonproductive modes of substrate binding in the active site. This model was tested via site-directed mutagenesis, and a number of these mutations abrogated substrate inhibition. However, the atomic structure of SalR shows that these mutated residues are instead distributed over a wide area of the enzyme, and many are not in the active site. To explain how residues distal to the active site might affect catalysis, a model is presented whereby SalR may undergo significant conformational changes during catalytic turnover.

Chronic Continuous Exenatide Infusion Does Not Cause Pancreatic Inflammation and Ductal Hyperplasia in Non-Human Primates

Science.gov (United States)

Fiorentino, Teresa Vanessa; Owston, Michael; Abrahamian, Gregory; La Rosa, Stefano; Marando, Alessandro; Perego, Carla; Di Cairano, Eliana S.; Finzi, Giovanna; Capella, Carlo; Sessa, Fausto; Casiraghi, Francesca; Paez, Ana; Adivi, Ashwin; Davalli, Alberto; Fiorina, Paolo; Guardado Mendoza, Rodolfo; Comuzzie, Anthony G.; Sharp, Mark; DeFronzo, Ralph A.; Halff, Glenn; Dick, Edward J.; Folli, Franco

2016-01-01

In this study, we aimed to evaluate the effects of exenatide (EXE) treatment on exocrine pancreas of nonhuman primates. To this end, 52 baboons (Papio hamadryas) underwent partial pancreatectomy, followed by continuous infusion of EXE or saline (SAL) for 14 weeks. Histological analysis, immunohistochemistry, Computer Assisted Stereology Toolbox morphometry, and immunofluorescence staining were performed at baseline and after treatment. The EXE treatment did not induce pancreatitis, parenchymal or periductal inflammatory cell accumulation, ductal hyperplasia, or dysplastic lesions/pancreatic intraepithelial neoplasia. At study end, Ki-67–positive (proliferating) acinar cell number did not change, compared with baseline, in either group. Ki-67–positive ductal cells increased after EXE treatment (P = 0.04). However, the change in Ki-67–positive ductal cell number did not differ significantly between the EXE and SAL groups (P = 0.13). M-30–positive (apoptotic) acinar and ductal cell number did not change after SAL or EXE treatment. No changes in ductal density and volume were observed after EXE or SAL. Interestingly, by triple-immunofluorescence staining, we detected c-kit (a marker of cell transdifferentiation) positive ductal cells co-expressing insulin in ducts only in the EXE group at study end, suggesting that EXE may promote the differentiation of ductal cells toward a β-cell phenotype. In conclusion, 14 weeks of EXE treatment did not exert any negative effect on exocrine pancreas, by inducing either pancreatic inflammation or hyperplasia/dysplasia in nonhuman primates. PMID:25447052

Effect of the use of curing salts and of a starter culture on the sensory and microbiological characteristics of homemade salamis

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Cinthia Bittencourt Spricigo

2005-06-01

Full Text Available Homemade salamis may have their food safety guaranteed by means of the addition of curing salt and starter cultures, without loosing their traditional manufacturing recipes brought to Brazil by the Italian immigration in the early 20th century. In this work, the influence of curing salt and of a starter culture, composed of Lactobacillus and Staphylococcus, over the sensory and microbiological characteristics of Italian type salamis, containing 3% lactose and 0.5% saccharose, was evaluated. The starter culture and the curing salt inhibited the development of Staphylococcus aureus and of coliforms, and the salamis added with curing salt presented better color attributes.Os salames produzidos artesanalmente podem ter sua segurança alimentar garantida pela adição de sal de cura e de culturas iniciadoras sem perda das receitas tradicionais trazidas pela imigração italiana do início do século vinte. Neste trabalho, a partir da produção de salames com 3% de lactose e 0,5% de sacarose, avaliou-se a influência do sal de cura e da cultura iniciadora, composta de Lactobacillus e Staphylococcus, sobre as características sensoriais e microbiológicas dos salames. A cultura iniciadora e o sal de cura inibiram o crescimento de Staphylococcus aureus e de coliformes totais, sendo que os salames adicionados de sal de cura apresentaram uma melhor coloração.

EFEITOS DO pH, SAL E DESNATURANTES NA HIDRÓLISE IN VITRO DA GLOBULINA PRINCIPAL DE GRÃO-DE-BICO (Cicer arietinum L., var. IAC-Marrocos*

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V. A. NEVES

2009-03-01

Full Text Available

As leguminosas caracterizam-se por apresentar alto teor protéico que na sua grande totalidade são globulinas de reserva,e cujas características moleculares influenciam algumas de suas propriedades com destaque para sua hidrólise frente às enzimas digestivas. As frações 7 e 11S, apesar de certa homologia estrutural, surgem como determinantes das propriedades nutritivas e funcionais das globulinas. Nesse trabalho a globulina principal de grão-de-bico (tipo legumina, 11S foi isolada e purificada, verificando-se o efeito da exposição a diferentes fatores na hidrólise in vitro com as enzimas tripsina e quimotripsina. Comparada à caseína, a globulina principal na forma nativa, e na presença de NaCl 0,3 M, mostrou-se menos susceptível à hidrólise pelas enzimas. A exposição a pHs ácidos extremos revela a retirada desse efeito protetor observado com o sal. As maiores alterações ocorreram pela exposição ao pH 1,0, temperatura de 121°C/15 min e presença de NaCl, no entanto ainda inferiores aos obtidos com a caseína e para ambas enzimas. O tratamento alcalino apesar de aumentar a susceptibilidade às enzimas mostrou valores de hidrólise inferiores à caseína. A exposição a diferentes concentrações dos desnaturantes uréia e hidrocloreto de guanidínio revelou que apenas o segundo teve pequeno efeito sobre a hidrólise pelas enzimas e, mesmo assim, em concentração tão alta como 8M. PALAVRAS-CHAVE: Grão-de-bico; Cicer arietinum L; globulina principal; hidrólise in vitro.

Is the transposition of the nipple-areolar complex necessary in Simon grade 2b gynecomastia operations using suction-assisted liposuction?

Science.gov (United States)

Özalp, Burhan; Berköz, Ömer; Aydınol, Mustafa

2018-02-01

The aim of this study was to assess the efficacy of suction-assisted liposuction (SAL) in Simon grade 2b gynecomastia and its effect on sternal notch to nipple areola (SNN) distance. A retrospective analysis was performed on 21 patients with grade 2b gynecomastia who underwent SAL. Preoperative and postoperative SNN distances of the patients were measured, the results were analysed using a Mann-Whitney U test and a p-value gynecomastia and shortens the SNN distance by 1 cm, but further clinical studies are required to support this conclusion.

Salt Iodation for Human Consumption in Processing Plants of Zulia State, Venezuela

OpenAIRE

Sánchez, Egar; García, Arelis; de Vale, María; Medina, Alberto; Contreras, Mary; Marín, Drucila; Vale, Oswaldo

2010-01-01

Con el objetivo de estudiar la concentración de yodo en la sal para consumo humano, se seleccionaron muestras de 70 empaques en cada una de tres plantas. Cuatro tiempos de almacenamiento, to=0 momento en que se seleccionó la muestra, t1= 2 meses, t2 = 4 meses y t3 = 6 meses, y dos temperaturas: ambiente (promedio de 32,7°C) y controlada (promedio de 38,5°C) fueron consideradas. A cada caso, 10 empaques de sal fueron asignados aleatoriamente realizando en cada empaque cinco...

Some regularities in formation and solvent extraction of complexes in metal-salicylic acid or its derivative- organic base systems

International Nuclear Information System (INIS)

Alimarin, I.P.; Fadeeva, V.I.; Tikhomirova, T.I.

1982-01-01

The influence of concentrations of the reagents, pH and solvent on the conditions for the formation and extraction of Sc, Ti, Zr, Hf, Th complexes has been examined in salicylic acid (H 2 Sal)-heterocyclic amine systems. The extraction chemism and factors, which affect the reactions between the metal ions and the ligands, are discussed. It has been shown that Zr, Hf, Ti form species of ion associate type, Sc and Th form different-ligand complexes under conditions for interphase equilibrium in a Me-H 2 Sal-heterocyclic amine system

Dental erozyon

NARCIS (Netherlands)

Özen, B.; Yönel, N.; Çetiner, S.

2015-01-01

Dental erozyon, plak içermeyen diş yüzeyleri üzerinde içsel ve dışsal asitlerin veya şelatların etkileriyle oluşan kimyasal bir aşınmadır. İçsel ve/veya dışsal kaynaklar nedensel faktörler olarak tanımlanırken tükürük ve pelikıl gibi biyolojik faktörler, yeme ve içme alışkanlıkları ve ağız hijyeni

Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells

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Saikali Melody

2012-07-01

Full Text Available Abstract Background Sesquiterpene lactones (SL are plant secondary metabolites that are known for their anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties. Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3-β-methoxy-iso-seco-tanapartholide (β-tan isolated from Achillea falcata and salograviolide A (Sal A isolated from Centaurea ainetensis, for their anti-tumor properties. We used the mouse epidermal JB6P + cells as a model for tumor promotion and cellular transformation. Key players that are involved in cellular transformation and tumorigenesis are the AP-1 and NF-κB transcription factors; therefore, we assessed how β-tan and Sal A modulate their signaling pathways in JB6P + cells. Methods The effects of β-tan and Sal A on the growth of normal and neoplastic keratinocytes and on the tumor promotion-responsive JB6P + cells were determined using the MTT assay. Anchorage-independent cell growth transformation assays were used to evaluate the anti-tumor promoting properties of these SL molecules in JB6P + cells and dual luciferase reporter assays and western blot analysis were used to investigate their effects on tumor promoter-induced AP-1 and NF-κB activities and protein levels of key AP-1 and NF-кB target genes. Results β-tan and Sal A selectively inhibited tumor promoter-induced cell growth and transformation of JB6P + cells at concentrations that do not affect JB6P + and primary keratinocytes basal cell growth. In addition, both molecules reduced basal and tumor promoter-induced NF-κB transcriptional activities, differentially regulated basal and tumor promoter-induced AP-1 transcriptional activities, and modulated key players of the AP-1 and NF-κB signaling pathways. Conclusions These results highlight the anti-tumor promoting properties of β-tan and Sal A. These SL molecules isolated from two plant species native to

Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells.

Science.gov (United States)

Saikali, Melody; Ghantous, Akram; Halawi, Racha; Talhouk, Salma N; Saliba, Najat A; Darwiche, Nadine

2012-07-09

Sesquiterpene lactones (SL) are plant secondary metabolites that are known for their anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties. Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3-β-methoxy-iso-seco-tanapartholide (β-tan) isolated from Achillea falcata and salograviolide A (Sal A) isolated from Centaurea ainetensis, for their anti-tumor properties. We used the mouse epidermal JB6P + cells as a model for tumor promotion and cellular transformation. Key players that are involved in cellular transformation and tumorigenesis are the AP-1 and NF-κB transcription factors; therefore, we assessed how β-tan and Sal A modulate their signaling pathways in JB6P + cells. The effects of β-tan and Sal A on the growth of normal and neoplastic keratinocytes and on the tumor promotion-responsive JB6P + cells were determined using the MTT assay. Anchorage-independent cell growth transformation assays were used to evaluate the anti-tumor promoting properties of these SL molecules in JB6P + cells and dual luciferase reporter assays and western blot analysis were used to investigate their effects on tumor promoter-induced AP-1 and NF-κB activities and protein levels of key AP-1 and NF-кB target genes. β-tan and Sal A selectively inhibited tumor promoter-induced cell growth and transformation of JB6P + cells at concentrations that do not affect JB6P + and primary keratinocytes basal cell growth. In addition, both molecules reduced basal and tumor promoter-induced NF-κB transcriptional activities, differentially regulated basal and tumor promoter-induced AP-1 transcriptional activities, and modulated key players of the AP-1 and NF-κB signaling pathways. These results highlight the anti-tumor promoting properties of β-tan and Sal A. These SL molecules isolated from two plant species native to the Middle East may provide opportunities for complementary

KONTROL ODAĞI VE ÖRGÜTSEL MUHALEFET ARASINDAKİ İLİŞKİ ÜZERİNE BİR ARAŞTIRMA

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Çiğdem KAYA

2017-12-01

Full Text Available Bu çalışmada çalışanların iş çevrelerindeki kontrol algılarının (kontrol odağının, örgütle ilgili anlaşmazlıklarını ve karşıt fikirlerini sözlü olarak ifade etme stratejileri (örgütsel muhalefet ile ilişkisinin incelenmesi amaçlanmıştır. Bu amaçla, İstanbul’da çeşitli sektörlerde faaliyet gösteren firmalarda çalışan 180 beyaz yakalı çalışandan toplanan veri analiz edilmiştir. Elde edilen sonuçlar, çalışanların kontrol odaklarının yapıcı açık muhalefet, dışsal muhalefet ve sorgulayıcı açık muhalefet ile ilişkili olduğunu göstermektedir. Kontrol odağı yapıcı açık muhalefeti ve sorgulayıcı açık muhalefeti negatif yönde açıklamakta, dışsal muhalefeti ise pozitif yönde açıklamaktadır. Bu sonuçlar, dışsal kontrol odağına sahip çalışanların dışsal muhalefet yapmaya eğilimli olup, yapıcı ve sorgulayıcı açık muhalefet yapmaktan kaçındıklarını göstermektedir. Kontrol odağı daha içsel kontrole doğru gittikçe çalışanlar yapıcı ve sorgulayıcı açık muhalefet yapmaya daha çok eğilimli olup, dışsal muhalefet yapma olasılıkları azalmaktadır.

Evaluation of a novel thermo-alkaline Staphylococcus aureus lipase for application in detergent formulations

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Abir Ben Bacha

2018-03-01

Full Text Available An extracellular lipase of a newly isolated S. aureus strain ALA1 (SAL4 was purified from the optimized culture medium. The SAL4 specific activity determined at 60 °C and pH 12 by using olive oil emulsion or TC4, reached 7215 U/mg and 2484 U/mg, respectively. The 38 NH2-terminal amino acid sequence of the purified enzyme starting with two extra amino acid residues (LK was similar to known staphylococcal lipase sequences. This novel lipase maintained almost 100% and 75% of its full activity in a pH range of 4.0–12 after a 24 h incubation or after 0.5 h treatment at 70 °C, respectively. Interestingly, SAL4 displayed appreciable stability toward oxidizing agents, anionic and non-ionic surfactants in addition to its compatibility with several commercial detergents. Overall, these interesting characteristics make this new lipase promising for its application in detergent industry. Keywords: Staphylococcus aureus lipase, Purification, Characterization, Thermo-alkaline, Detergent-stable

Lidar Observations of Aerosol Disturbances of the Stratosphere over Tomsk (56.5∘N; 85.0∘E in Volcanic Activity Period 2006–2011

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Oleg E. Bazhenov

2012-01-01

Full Text Available The lidar measurements (Tomsk: 56.5∘N; 85.0∘E of the optical characteristics of the stratospheric aerosol layer (SAL in the volcanic activity period 2006–2011 are summarized and analyzed. The background SAL state with minimum aerosol content, observed since 1997 under the conditions of long-term volcanically quiet period, was interrupted in October 2006 by series of explosive eruptions of volcanoes of Pacific Ring of Fire: Rabaul (October 2006, New Guinea; Okmok and Kasatochi (July-August 2008, Aleutian Islands; Redoubt (March-April 2009, Alaska; Sarychev Peak (June 2009, Kuril Islands; Grimsvötn (May 2011, Iceland. A short-term and minor disturbance of the lower stratosphere was also observed in April 2010 after eruption of the Icelandic volcano Eyjafjallajokull. The developed regional empirical model of the vertical distribution of background SAL optical characteristics was used to identify the periods of elevated stratospheric aerosol content after each of the volcanic eruptions. Trends of variations in the total ozone content are also considered.

Validation data supporting the characterization of novel copper complexes as anticancer agents

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Ceyda Acilan

2016-12-01

Full Text Available Three copper(II complexes, Cu(Sal-Gly(phen, Cu(Sal-Glypheamine, Cu(Sal-Glyphepoxy were synthesized and characterized for their anticancer properties and mechanism of action (Acilan et al., in press [1]. Here, we provide supporting data on colon cancer cell lines complementing our previous findings in cervix cells. This paper also contains a data table for the fold changes and p-values of all genes analyzed in this study via a custom RT-qPCR array. All compounds induced DNA damage (based on 8-oxo-guanidine, ɣH2AX staining in cells and apoptosis (based on elevated DNA condensation/fragmentation, Annexin V staining, caspase 3/7 activity and mitochondrial membrane depolarization in HCT-116 colon cancer cells. The increase in oxidative stress was also further confirmed in these cells. Further interpretation of the data presented here can be found in the article entitled “Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents” (Acilan et al., in press [1].

Blocking opioid receptors alters short-term feed intake and oro-sensorial preferences in weaned calves.

Science.gov (United States)

Montoro, C; Ipharraguerre, I R; Bach, A

2012-05-01

Opioid peptides may participate in the control of feed intake through mechanisms involving pleasure reward linked to consumption of palatable feed. The objective of this study was to determine whether blocking opioid receptors might void oro-sensorial preferences of calves, and affect circulating glucose, insulin, and anorexigenic hormones in fasted and fed calves. Two experiments involved 32 Holstein calves [body weight (BW)=86.5±1.73 kg, age=72±0.6 d]. In experiment 1, all calves received an ad libitum choice of the same feed either unflavored or flavored with a sweetener (Luctarom SFS-R, Lucta, Montornès del Vallès, Spain). Feed consumption was recorded every 2 h from 0800 to 1400 h for 3 consecutive days to verify the establishment of an oro-sensorial preference for sweet feed (SF). The SF was preferred over the control feed (CF) at all recorded times. In experiment 2, calves were subjected to a 2 × 2 factorial design to study the interaction between opioid activity and metabolic state. Half of the calves were fasted for 14 h (FAS), whereas the other half remained well fed (FED). Within each of these groups, at feeding time (0800 h), half of the calves received an i.v. injection of naloxone (NAL, an opioid receptor antagonist; 1 mg/kg of BW) and the other half was injected with saline solution (SAL; 0.9% NaCl). Therefore, treatments were FED-NAL, FED-SAL, FAS-NAL, and FAS-SAL. Blood samples were taken at -10, 20, 180, and 240 min relative to NAL or SAL injections. As expected, cumulative consumption of starter feed was greater in FAS than in FED calves. Total feed consumption 2 h after feeding was lower in NAL than in SAL calves. Calves in the FAS group did not discern between CF and SF during the first 4 h after feed offer. Preference for SF was greater in SAL than in NAL calves. Calves in the FED-SAL treatment preferred SF at 2 and 6 h after feed offer and tended to prefer SF at 4 h after feeding. However, FED-NAL calves did not discern between SF and CF

Unmasking the powers behind the party / Aigars Stokenbergs ; interv. Talis Saule Archdeacon

Index Scriptorium Estoniae

Stokenbergs, Aigars

2007-01-01

Endine Läti regionaalminister Aigars Stokenbergs parteist ja valitsusest lahkumisest, valitsuse ebastabiilsusest, võimalikust uuest parteist ning nn. oligarh Andris Skele rollist Lätis. Aigars Stokenbergs'i CV

Autoralli MM-sarja ootab ees vaheaasta / Ivo Dobkevitš ; fotod Karli Saul

Index Scriptorium Estoniae

Dobkevitsch, Ivo, 1973-

2009-01-01

Tehasetiimide majandusraskustest ja vähesest huvist autoralli MM-sarja vastu 2009. aastal ning FIA poolt kehtestatavatest tehnilistest muudatustest 2010. aastal. Samas: Urmo Aava hooaega vahele jätta ei kavatse

Tommy Wilhelm: The Untraditional Hero of Saul Bellow’s Seize the Day

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Md Abu Shahid Abdullah

2015-10-01

Full Text Available Many critics have judged Tommy Wilhelm in terms of his weaknesses only and have considered him a complete failure, far from being a hero. But many of them have failed to see the bright side of Tommy’s character. He possesses rare human qualities completely alien to the citizens of a morally corrupt society. The article aims to  prove that in spite of possessing various negative and unheroic qualities, Tommy, by defying social structure and network, asserts his non-conformity which, along with his humanity, love and philanthropy, aversion for power and material success and most importantly, his power of overcoming humiliation, secures him the position of a hero although an untraditional one. The narrative structure also plays a significant role behind his being a hero. Keywords: Materialism, Untraditional hero, Humanity, Non-conformity

Avalynės tinklo „BONA“ komunikacijos plano parengimas

OpenAIRE

Kuzmickaitė, Simona

2009-01-01

Avalynės tinklas „BONA“, priklausantis UAB „Kauno Saulėtekis“, prekiauja įvairia moteriška bei vyriška avalyne. Avalynės parduotuvių tinklas „BONA“ plėtoti savo veiklą pradėjo tik nuo 2004 metų, tačiau praėjus vos trejiems metams vis labiau užsitikrina tvirtą poziciją avalynės rinkoje. Per tuos trejus metus įmonė sugebėjo atidaryti 17 šio tinklo parduotuvių, kurių yra visoje Lietuvoje: Kaune (4 parduotuvės), Vilniuje (3 parduotuvės), Klaipėdoje (2 parduotuvės), Šiauliuose (1 parduotuvė), Plun...

Looking Back in Anger. Bianciardi and the Masks of Melancholia

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Diego Varini

2017-11-01

Full Text Available This paper analyzes the concept and perception of melancholia in Luciano Bianciardi’s works, in the context of his cultural framework and especially the American authors he deeply knew as translator. Through close reading and discourse analysis, the melancholia originating from Bianciardi’s critique to contemporary life and his simultaneous tragic inability to find a suitable alternative is traced in some of his literary works and compared to the American antecedents. The conclusion pinpoints the similarities between the social and cultural representation brought about by authors such as Saul Bellow and John Barth, and the (even more complex and contradictory reading of Italian society of the Sixties performed in Bianciardi’s works.

Préférence et sensibilité aux aliments apportant les goûts gras, sucré, salé et amer et état pondéral [Preference and sensitivity to food providing fatty, sweet, salty and bitter tastes, and weight status

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Ouassila ALLAM

2017-12-01

Full Text Available Résumé Introduction. Le goût est une modalité sensorielle chimique qui permet d'apprécier les saveurs d'une substance ingérée. Il joue un rôle essentiel dans la sélection des aliments. Objectif. Déterminer le niveau de sensibilité gustative aux goûts gras, sucré, salé et amer, à travers les préférences alimentaires et étudier le lien possible avec l’état pondéral. Matériel et méthodes. L’étude a porté sur 210 jeunes adultes (F/H, 157/53 âgés de 18 à 30 ans. Les mesures anthropométriques concernent le poids et la taille. Le questionnaire utilisé a permis l'évaluation des préférences alimentaires en relation avec différentes saveurs. Le niveau de sensibilité est estimé à partir des scores moyens de préférence attribués à chaque groupe d’aliments apportant le goût étudié. L’analyse statistique est réalisée avec le logiciel StatView. Résultats. Notre population compte 45,7% de sujets en surpoids dont 20% d’obèses. Le pourcentage du surpoids est plus élevé chez les femmes que chez les hommes (p=0,04. Une relation significative est trouvée entre la préférence au gras rajouté et l’état pondéral des adultes (p=0,0003. Aucune différence significative n’est trouvée entre le niveau de préférence ou de sensibilité pour les aliments sucrés, salés ou amers et l’état pondéral des adultes. Conclusion. Les adultes en surpoids présentent le niveau de préférence le plus faible et sont les moins sensibles par rapport au gras rajouté, ce qui peut influencer l’état pondéral par une consommation excessive d’aliments riches en gras. [ Abstract Introduction. Taste is a chemical sensory modality allowing to appreciate the flavors of an ingested substance. It plays an essential role in food choice. Objective. To define the level of taste sensitivity to fatty, sweet, salty and bitter tastes through food preferences and to study the possible link with weight status. Material and

Los orígenes de la exhibición cinematográfica en Sevilla a través de la prensa

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Mónica Barrientos Bueno

2006-01-01

Full Text Available La prensa local diaria de Sevilla entre 1896 y 1906 se convierte en instrumento de indudable utilidad para el estudio y conocimiento de la llegada del cinematógrafo a la ciudad, suaceptación e implantación. Las informaciones al respecto, aunque aparecen dispersas y sinsistematizar, garantizan cronologías, títulos de películas junto a otros aspectos. Los datos obtenidos, al margen de particularidades locales, revelan que la realidad sevillana no difiere de otras. Se destacan y comentan siete artículos representativos que tratan la evolución de la fotografía hasta el cinematógrafo, el “enfrentamiento” de cine y teatro, la primera huelga de la industria en Sevilla, la política de algunos empresarios exhibidores y las informaciones de dos espacios –Salón Gaumont y Salón Imperial- en 1906.The Sevillian diary press from 1896 to 1906 becomes an important instrument to study and know of the arriving of the cinematograph to Seville, its acceptance and implantation. Although the press informations about cinema are scattered and disordered, chronologies,titles of films and others aspects are warranted. Despite of local aspects, the facts obtained, reveal that the Sevillian reality wasn´t different from others. Seven representative articles are commented: the photography evolution to the cinematograph, the confrontationbetween theatre and cinema, the first strike of exhibition industry in Seville, the customs of some managers and the information about two representative places in 1906: Salón Gaumont and Salón Imperial

Prenatal treatment prevents learning deficit in Down syndrome model.

Science.gov (United States)

Incerti, Maddalena; Horowitz, Kari; Roberson, Robin; Abebe, Daniel; Toso, Laura; Caballero, Madeline; Spong, Catherine Y

2012-01-01

Down syndrome is the most common genetic cause of mental retardation. Active fragments of neurotrophic factors release by astrocyte under the stimulation of vasoactive intestinal peptide, NAPVSIPQ (NAP) and SALLRSIPA (SAL) respectively, have shown therapeutic potential for developmental delay and learning deficits. Previous work demonstrated that NAP+SAL prevent developmental delay and glial deficit in Ts65Dn that is a well-characterized mouse model for Down syndrome. The objective of this study is to evaluate if prenatal treatment with these peptides prevents the learning deficit in the Ts65Dn mice. Pregnant Ts65Dn female and control pregnant females were randomly treated (intraperitoneal injection) on pregnancy days 8 through 12 with saline (placebo) or peptides (NAP 20 µg +SAL 20 µg) daily. Learning was assessed in the offspring (8-10 months) using the Morris Watermaze, which measures the latency to find the hidden platform (decrease in latency denotes learning). The investigators were blinded to the prenatal treatment and genotype. Pups were genotyped as trisomic (Down syndrome) or euploid (control) after completion of all tests. two-way ANOVA followed by Neuman-Keuls test for multiple comparisons, PDown syndrome-placebo; n = 11) did not demonstrate learning over the five day period. DS mice that were prenatally exposed to peptides (Down syndrome-peptides; n = 10) learned significantly better than Down syndrome-placebo (ptreatment with the neuroprotective peptides (NAP+SAL) prevented learning deficits in a Down syndrome model. These findings highlight a possibility for the prevention of sequelae in Down syndrome and suggest a potential pregnancy intervention that may improve outcome.

Karyotype characteristics, larval morphology and chromosomal polymorphism peculiarities of Glyptotendipes salinus Michailova, 1983 (Diptera, Chironomidae) from Tambukan Lake, Central Caucasus

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Karmokov, Mukhamed Kh.; Akkizov, Azamat Y.

2016-01-01

Abstract Data on the karyotype characteristics, larval morphology and features of chromosomal polymorphism of a population of Glyptotendipes salinus Michailova, 1983 (Diptera, Chironomidae) from Tambukan Lake (on the northern macroslope of the central Caucasus) are presented. It was found that diagnostic larval characters of Glyptotendipes salinus from Caucasus in general are similar to those described in previous studies, but with some significant differences. By some morphological characteristics Caucasian larvae appeared to be closer to Glyptotendipes barbipes than to ones provided for European larvae of Glyptotendipes salinus by Contreras-Lichtenberg (1999). Obtained morphological data make possible to conclude that Caucasian population of Glyptotendipes salinus can be a markedly diverged population of the species, probably even subspecies. In the Caucasian population 12 banding sequences were found: two in arms A, B, C, E, and G, and one in arms D and F. Eight of these are already known for this species, and four, salA2, salB2, salEX, and salG3, are described for the first time. Genetic distances between all the previously studied populations of Glyptotendipes salinus were measured using Nei criteria (1972). The population of the central Caucasus occupies a distinct position on the dendrogram compared with populations from Altai and Kazakhstan. All the obtained morphological and cytogenetic data can indicate the plausible relative isolation and complexity of the Caucasus from the viewpoint of microevolution. More researches are required in other parts of Caucasus and other geographically distant regions for more specific allegations. PMID:28123679

Some Biological Activities of Malaysian Leech Saliva Extract

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Abdualrahman M. Abdualkader

2011-12-01

Full Text Available Normal 0 21 false false false MS X-NONE AR-SA Leeches were fed on the phagostimulatory solution through parafilm membrane. The satiated leeches were forced to regurgitate the solution by soaking them in an ice-container. The anticoagulant activity was ascertained using thrombin time assay (TT. The result revealed that the saliva concentration which increases TT by 100% (IC100 is 43.205µg/ml plasma. The antimicrobial activity of the saliva was tested against several bacterial spp. (E.coli, P.aeruginosa, B.cereus, Sal.typhi and S.aureus  and fungi spp. (C.albicans and C.neoformans. It was found that saliva has an inhibition activity against Sal.typhi (minimal inhibitory concentration MIC 78.253µg/ml, S.aureus (MIC 78.253µg/ml and E.coli (MIC 121.256µg/ml.ABSTRAK: Pacat-pacat diberi makan larutan phagostimulatory menerusi membran parafilem. Pacat-pacat yang kekenyangan itu dipaksa memuntahkan larutan tersebut dengan direndam di dalam bekas berisi ais. Aktiviti antigumpal ditentukan menggunakan cerakin masa trombin (TT. Keputusan menunjukkan kepekatan air liur pacat menyebabkan pertambahan TT sebanyak 100% (IC100 iaitu 43.205µg/ml plasma. Aktiviti antimikrob air liur telah diuji dengan pelbagai jenis bakteria (E.coli, P.aeruginosa, B.cereus, Sal.typhi dan S.aureus dan pelbagai jenis kulat (C.albicans and C.neoformans. Didapati air liur menghasilkan aktiviti perencatan terhadap Sal.typhi (kepekatan perencat minima (Minimal inhibitory concentration - MIC 78.253µg/ml, S.aureus (MIC 78.253µg/ml dan E.coli (MIC 121.256µg/ml.

Karyotype characteristics, larval morphology and chromosomal polymorphism peculiarities of Glyptotendipes salinus Michailova, 1983 (Diptera, Chironomidae from Tambukan Lake, Central Caucasus

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Mukhamed Karmokov

2016-11-01

Full Text Available Data on the karyotype characteristics, larval morphology and features of chromosomal polymorphism of a population of Glyptotendipes salinus Michailova, 1983 (Diptera, Chironomidae from Tambukan Lake (on the northern macroslope of the central Caucasus are presented. It was found that diagnostic larval characters of G. salinus from Caucasus in general are similar to those described in previous studies, but with some significant differences. By some morphological characteristics Caucasian larvae appeared to be closer to G. barbipes than to ones provided for European larvae of G. salinus by Contreras-Lichtenberg (1999. Obtained morphological data make possible to conclude that Caucasian population of G. salinus can be a markedly diverged population of the species, probably even subspecies. In the Caucasian population 12 banding sequences were found: two in arms A, B, C, E, and G, and one in arms D and F. Eight of these are already known for this species, and four, salA2, salB2, salEX, and salG3, are described for the first time. Genetic distances between all the previously studied populations of G. salinus were measured using Nei criteria (1972. The population of the central Caucasus occupies a distinct position on the dendrogram compared with populations from Altai and Kazakhstan. All the obtained morphological and cytogenetic data can indicate the plausible relative isolation and complexity of the Caucasus from the viewpoint of microevolution. More researches are required in other parts of Caucasus and other geographically distant regions for more specific allegations.

Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats.

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Drotningsvik, Aslaug; Mjøs, Svein A; Pampanin, Daniela M; Slizyte, Rasa; Carvajal, Ana; Remman, Tore; Høgøy, Ingmar; Gudbrandsen, Oddrun A

2016-10-01

The world's fisheries and aquaculture industries produce vast amounts of protein-containing by-products that can be enzymatically hydrolysed to smaller peptides and possibly be used as additives to functional foods and nutraceuticals targeted for patients with obesity-related metabolic disorders. To investigate the effects of fish protein hydrolysates on markers of metabolic disorders, obese Zucker fa/fa rats consumed diets with 75 % of protein from casein/whey (CAS) and 25 % from herring (HER) or salmon (SAL) protein hydrolysate from rest raw material, or 100 % protein from CAS for 4 weeks. The fatty acid compositions were similar in the experimental diets, and none of them contained any long-chain n-3 PUFA. Ratios of lysine:arginine and methionine:glycine were lower in HER and SAL diets when compared with CAS, and taurine was detected only in fish protein hydrolysate diets. Motifs with reported hypocholesterolemic or antidiabetic activities were identified in both fish protein hydrolysates. Rats fed HER diet had lower serum HDL-cholesterol and LDL-cholesterol, and higher serum TAG, MUFA and n-3:n-6 PUFA ratio compared with CAS-fed rats. SAL rats gained more weight and had better postprandial glucose regulation compared with CAS rats. Serum lipids and fatty acids were only marginally affected by SAL, but adipose tissue contained less total SFA and more total n-3 PUFA when compared with CAS. To conclude, diets containing hydrolysed rest raw material from herring or salmon proteins may affect growth, lipid metabolism, postprandial glucose regulation and fatty acid composition in serum and adipose tissue in obese Zucker rats.

Prenatal exposure to dexamethasone in the mouse alters cardiac growth patterns and increases pulse pressure in aged male offspring.

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Lee O'Sullivan

Full Text Available Exposure to synthetic glucocorticoids during development can result in later cardiovascular and renal disease in sheep and rats. Although prenatal glucocorticoid exposure is associated with impaired renal development, less is known about effects on the developing heart. This study aimed to examine the effects of a short-term exposure to dexamethasone (60 hours from embryonic day 12.5 on the developing mouse heart, and cardiovascular function in adult male offspring. Dexamethasone (DEX exposed fetuses were growth restricted compared to saline treated controls (SAL at E14.5, but there was no difference between groups at E17.5. Heart weights of the DEX fetuses also tended to be smaller at E14.5, but not different at E17.5. Cardiac AT1aR, Bax, and IGF-1 mRNA expression was significantly increased by DEX compared to SAL at E17.5. In 12-month-old offspring DEX exposure caused an increase in basal blood pressure of ~3 mmHg. In addition, DEX exposed mice had a widened pulse pressure compared to SAL. DEX exposed males at 12 months had an approximate 25% reduction in nephron number compared to SAL, but no difference in cardiomyocyte number. Exposure to DEX in utero appears to adversely impact on nephrogenesis and heart growth but is not associated with a cardiomyocyte deficit in male mice in adulthood, possibly due to compensatory growth of the myocardium following the initial insult. However, the widened pulse pressure may be indicative of altered vascular compliance.

Impact of introducing subsidized combination treatment with artemether-lumefantrine on sales of anti-malarial monotherapies: a survey of private sector pharmacies in Huambo, Angola.

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Lussiana, Cristina; Floridia, Marco; Martinho do Rosário, Joana; Fortes, Filomeno; Allan, Richard

2016-12-01

Artemisinin-based combination therapies (ACTs) against malaria are subsidized in many African countries, but the impact of subsidy programs in reducing the sales of concomitantly available antimalarial monotherapies is poorly defined. Data from The MENTOR initiative, that introduced subsidized artemether-lumefantrine (sAL) in the private sector of Huambo province, Angola, were used. The main response variable was represented by sales of sAL and of monotherapies, measured as number of treatment courses. Sales in private pharmacies of sAL and four antimalarial monotherapies between 2009 and 2013 were organized in four time-periods, and analyzed using generalized linear models for repeated measures. A secondary analysis evaluated changes in relative market share. We analyzed data from 34 pharmacies at four time points, taken from a larger survey that involved 165 pharmacies between June 2009 and March 2013. The sAL, following its introduction, became the dominant antimalarial treatment in the private sector, usually exceeding the total sales of all antimalarial monotherapies combined (1480/2800 total treatment courses, 52.8% of all sales in March 2013). Sales of monotherapies decreased significantly, but did not stop, representing 36.7% (1028/2800) of sales at the end of the survey. Subsidized ACTs can attain rapidly a high relative market share. Their introduction reduced, but did not eliminate the demand for less effective monotherapies, that might favor parasite resistance. © The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Some high coordination compounds of lanthanides(III derived from N-isonicotinamidosalicyaldimine

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Ram K. Agarwal

2000-12-01

Full Text Available A new series of lanthanide(III nitrates, isothiocyanates and perchlorates coordination complexes of N-isonicotinamidosalicyaldimine (INH-SAL with the general composition LnX3.n(INH-SAL (Ln = La, Pr, Nd, Sm, Gd, Tb or Dy; X = NO3-, n = 2; X = NCS-, n = 2 or 3 and X = ClO4-, n = 4 have been reported. All the complexes were characterized by chemical analyses, conductance, molar weight, magnetic moment measurements, infrared and electronic spectra. IR spectra indicate that the ligand behaves as a neutral N,O-donors. Thermal properties of the complexes have also been studied.

Thermal decomposition of anhydrous zinc and cadmium salicylates

International Nuclear Information System (INIS)

Kharitonov, Yu.Ya.; Tujebakhova, Z.K.

1984-01-01

On the basis of studying thermograms, thermogravigrams, IR absorption spectra, X-rayograms of anhydrous znc and cadmium salicylate complexes of the M(HSal) 2 composition, (where M=Zn, Cd; HSal is an anion of once deprotonated salicyclic acid H 2 Sal) and products of their thermal transformations, the processes are characterized of stage-by-stage thermal decomposition of these compounds under continuous heating in the air from room temperature to approximately 1000 deg C. It is shown that the Cd(HSal) 2 pyrolysis proceeds with the formation of CdSal at 170-250 deg C and CdO - at 320-460 deg C

Technologies applied to wells producing gas in Bolivia; Tecnologias aplicadas aos pocos produtores de gas em Bolivia

Energy Technology Data Exchange (ETDEWEB)

Nobrega, Fernando R.B. [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil); Carrillo, Marco A.; Barrerro, Dennys A. [PETROBRAS Bolivia S.A., La Paz (Bolivia)

2012-07-01

The This paper seeks to highlight the engineering, lessons learned and topics for improvement of the technologies used in gas wells drilled between November 2008 and October 2011 in an environment of Bolivian' subandino. Among technologies employed and commented hereunder has the drilling gas reservoirs in near balance using a dual phase fluid, with nitrogen; carrying out multilateral wells equipped with intelligent completion in such environment; as well as other technologies presented herein. This document was prepared on drilling operations performed in SAL-15, SAL-17, SBLSBL- 7 and SBL-8, comprising the period from November 2008 to October 2011. (author)

Qualidade protéica de pão de sal contendo farinha de linhaça (Linum usitatissimum L.
Protein quality of “french” bread containing flaxseed flour

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J. T. S. BORGES

2010-09-01

Full Text Available

As proteínas são moléculas essenciais aos organismos animais, devendo, portanto, estar presentes na alimentação em quantidades adequadas. Além do aspecto quantitativo deve-se considerar o aspecto qualitativo, isto é, seu valor nutricional, que dependerá da composição, digestibilidade, biodisponibilidade de aminoácidos essenciais, ausência de toxicidade e de fatores antinutricionais. O objetivo do presente estudo foi determinar a digestibilidade in vivo e a qualidade nutricional de proteínas de pães de sal obtidos com farinhas mistas de trigo e linhaça integral nas proporções de 90:10 e 85:15. Os melhores resultados para ganho de peso, coefi ciente de efi cácia alimentar, coefi ciente de efi cácia protéica e razão protéica líquida foram obtidos quando maior teor de farinha de trigo foi substituído pela farinha integral de linhaça na formulação dos pães. A lisina foi o primeiro aminoácido limitante em todos os produtos elaborados. A substituição parcial da farinha de trigo pela farinha de linhaça não melhorou a qualidade protéica dos pães estudados.

Biodiversity and phylogenetic analysis of culturable bacteria indigenous to Khewra salt mine of Pakistan and their industrial importance Biodiversidade e análise filogenética de bactérias cultiváveis indígenas da mina de sal Khewra, Paquistão e sua importância industrial

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Nasrin Akhtar

2008-03-01

Full Text Available Culturable bacterial biodiversity and industrial importance of the isolates indigenous to Khewra salt mine, Pakistan was assessed. PCR Amplification of 16S rDNA of isolates was carried out by using universal primers FD1 and rP1and products were sequenced commercially. These gene sequences were compared with other gene sequences in the GenBank databases to find the closely related sequences. The alignment of these sequences with sequences available from GenBank database was carried out to construct a phylogenetic tree for these bacteria. These genes were deposited to GenBank and accession numbers were obtained. Most of the isolates belonged to different species of genus Bacillus, sharing 92-99% 16S rDNA identity with the respective type strain. Other isolates had close similarities with Escherichia coli, Staphylococcus arlettae and Staphylococcus gallinarum with 97%, 98% and 99% 16S rDNA similarity respectively. The abilities of isolates to produce industrial enzymes (amylase, carboxymethylcellulase, xylanase, cellulase and protease were checked. All isolates were tested against starch, carboxymethylcellulose (CMC, xylane, cellulose, and casein degradation in plate assays. BPT-5, 11,18,19 and 25 indicated the production of copious amounts of carbohydrates and protein degrading enzymes. Based on this study it can be concluded that Khewra salt mine is populated with diverse bacterial groups, which are potential source of industrial enzymes for commercial applications.Avaliou-se a biodiversidade e a importância industrial de bactérias indígenas da mina de sal Khewra, Paquistão. Efetuou-se a amplificação do 16S rDNA dos isolados por PCR empregando-se os iniciadores universais FD1 e rP1, e os produtos foram seqüenciados comercialmente. Essas seqüências de genes foram comparadas com outras seqüências disponíveis no GenBank a fim de encontrar seqüências relacionadas, construindo-se uma árvore filogenética para essas bactérias. Os genes

Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study.

Science.gov (United States)

Shijo, Katsunori; Sutton, Richard L; Ghavim, Sima S; Harris, Neil G; Bartnik-Olson, Brenda L

2017-01-01

Administration of sodium pyruvate (SP; 9.08 μmol/kg, i.p.), ethyl pyruvate (EP; 0.34 μmol/kg, i.p.) or glucose (GLC; 11.1 μmol/kg, i.p.) to rats after unilateral controlled cortical impact (CCI) injury has been reported to reduce neuronal loss and improve cerebral metabolism. In the present study these doses of each fuel or 8% saline (SAL; 5.47 nmoles/kg) were administered immediately and at 1, 3, 6 and 23 h post-CCI. At 24 h all CCI groups and non-treated Sham injury controls were infused with [1,2 13 C] glucose for 68 min 13 C nuclear magnetic resonance (NMR) spectra were obtained from cortex + hippocampus tissues from left (injured) and right (contralateral) hemispheres. All three fuels increased lactate labeling to a similar degree in the injured hemisphere. The amount of lactate labeled via the pentose phosphate and pyruvate recycling (PPP + PR) pathway increased in CCI-SAL and was not improved by SP, EP, and GLC treatments. Oxidative metabolism, as assessed by glutamate labeling, was reduced in CCI-SAL animals. The greatest improvement in oxidative metabolism was observed in animals treated with SP and fewer improvements after EP or GLC treatments. Compared to SAL, all three fuels restored glutamate and glutamine labeling via pyruvate carboxylase (PC), suggesting improved astrocyte metabolism following fuel treatment. Only SP treatments restored the amount of [4 13 C] glutamate labeled by the PPP + PR pathway to sham levels. Milder injury effects in the contralateral hemisphere appear normalized by either SP or EP treatments, as increases in the total pool of 13 C lactate and labeling of lactate in glycolysis, or decreases in the ratio of PC/PDH labeling of glutamine, were found only for CCI-SAL and CCI-GLC groups compared to Sham. The doses of SP, EP and GLC examined in this study all enhanced lactate labeling and restored astrocyte-specific PC activity but differentially affected neuronal metabolism after CCI injury. The restoration of

Efectividad de las modificaciones de estilo de vida sobre el control de la presión arterial en pacientes hipertensos

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Baquero Lorenzo A.

2016-09-01

Full Text Available ntroducción: Las modificaciones del estilo de vida han demostrado ser eficaces para el control de la presión arterial (PA. El objetivo de este trabajo es evaluar el efecto de la reducción del consumo de sal en la PA en hipertensos, conocer la calidad de la dieta y comprobar la adherencia a las recomendaciones dietéticas y de actividad física. Material y métodos: Estudio cuasiexperimental no controlado. Se seleccionaron aleatoriamente sujetos hipertensos a los que se realizó una entrevista estructurada para conocer sus hábitos de alimentación, consumo de sal y actividad física. Se determinaron las variables antropométricas y la PA. Se entregaron por escrito recomendaciones dietéticas y de actividad física. A los 30 días se reevaluaron. Resultados: 30 sujetos (17 mujeres y 13 varones, edad media 65,3±12,1 años. El 73,3% refería realizar dieta baja en sal. La calidad de la dieta mostró que la mayoría de los sujetos necesitaban cambios en su alimentación y eran sedentarios. Índice de masa corporal de 28,3±4,8 Kg/m2. PA sistólica de 139,1±18,9 mmHg y diastólica 81,8±10,1 mmHg. Segunda visita sin cambios en calidad de la dieta ni en actividad física aunque sí disminución en consumo de sal (p=0,028. PA sistólica media de 133,3±16,2 mmHg y diastólica 77,8±11,2 mmHg (p=0,04 en sistólica y p=0,01 en diastólica. Conclusiones: La disminución del consumo de sal se asoció de forma estadísticamente significativa a una reducción de las cifras de PA. La calidad de la dieta de la muestra fue subóptima y la adherencia a las recomendaciones de estilo de vida baja.

Effects of Growth Hormone/IGF-I and Exercise on Unloaded Bones

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Harper, J. S.; Arnaud, S. B.; Gosselink, K. L.; Grindeland, R. E.

1994-01-01

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) in combination with exercise prevent muscle atrophy induced by unloading in the tail-suspension rat model for space flight (Gosselink et al, FASEB J 1994). This study evaluated the effects of these treatments on bone. Hypophysectomized rats were suspended (S) and treated with 1mg/kg/day CH plus IGF-I (H) or vehicle (Sal) daily by injection and exercised (Ex) by 3 climbs up a 1m ladder carrying a load equal to 30% the initial body weight (BW) 3x/day for 10 days. Tibial epiphysis (Epi) widths were measured by micrometry and femoral Bone Mineral Content (fBMC) in excised femurs by DEXA (Lunar DPX-L). Serum calcium (Ca) and phosphorus (Pi) were measured by COBAS Autoanalyzer (Roche Diag.). Ambulatory (Amb)-H treated rats showed growth rates of 6.6+-0.9 g/day, similar to S-H-Ex and higher than S-H (3.210.6, p less than 0.05) and S-Sal (-0.711.0, p less than 0.05). Epi widths were 10% lower in S-Sal, and S-Sal-Ex, and increased 100% in all H groups. fBMC was less in S than Amb, only when all S groups are compared to both Amb groups (p less than 0.03). H treatment increased fBMC (p less than 0.05) but reduced fBMC/100g BW in all H groups (p less than 0.001). The reduced density of H bone cannot be attributed to low circulating Ca. and Pi since they were higher in H than Sal (p less than 0.001). H treatment for 10 days in doses sufficient to support normal growth in BW failed to produce normal Epi widths or fBMC, even when combined with exercise. The suspension effect observed in Epi widths was not corrected by H or Ex alone, but was improved by H plus a This regimen. although effective in preventing muscle atrophy, failed to return bone measures, Epi widths and fBMC, to normal.

Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties.

Science.gov (United States)

Liu, Miao; Zheng, Mingjing; Xu, Hanying; Liu, Lianqing; Li, Yanchun; Xiao, Wei; Li, Jianchun; Ma, Enlong

Various methods have been used to evaluate anti-fibrotic activity of drugs. However, most of them are complicated, labor-intensive and lack of efficiency. This study was intended to develop a rapid method for anti-fibrotic drugs screening based on biophysical properties. A549 cells in vitro were stimulated with transforming growth factor-β1 (TGF-β1), and fibrogenesis was confirmed by conventional immunological assays. Meanwhile, the alterations of cyto-biophysical properties including morphology, roughness and stiffness were measured utilizing atomic force microscopy (AFM). It was found that fibrogenesis was accompanied with changes of cellular biophysical properties. TGF-β1-stimulated A549 cells became remarkably longer, rougher and stiffer than the control. Then, the effect of N-acetyl-L-cysteine (NAC) as a positive drug on ameliorating fibrogenesis in TGF-β1-stimulated A549 cells was verified respectively by immunological and biophysical markers. The result of Principal Component Analysis showed that stiffness was a leading index among all biophysical markers during fibrogenesis. Salvianolic acid B (SalB), a natural anti-oxidant, was detected by AFM to protect TGF-β1-stimulated A549 cells against stiffening. Then, SalB treatment was provided in preventive mode on a rat model of bleomycin (BLM) -induced pulmonary fibrosis. The results showed that SalB treatment significantly ameliorated BLM-induced histological alterations, blocked collagen accumulations and reduced α-SMA expression in lung tissues. All these results revealed the anti-pulmonary fibrotic activity of SalB. Detection of cyto-biophysical properties were therefore recommended as a rapid method for anti-pulmonary fibrotic drugs screening. Copyright © 2015 Elsevier Inc. All rights reserved.

Evaluation of injectable anaesthesia with five medetomidine-midazolam based combinations in Egyptian fruit bats ( Rousettus aegyptiacus).

Science.gov (United States)

Tuval, Avishag; Las, Liora; Shilo-Benjamini, Yael

2018-01-01

Egyptian fruit bats are increasingly used as model animals in neuroscience research. Our aim was to characterize suitable injectable anaesthesia for this species, possibly replacing inhalant anaesthesia, thus minimizing occupational health hazards. Eight bats were randomly assigned by a crossover design for subcutaneously administered combinations of medetomidine-midazolam with: saline (MM-Sal), ketamine (MM-Ket), fentanyl (MM-Fen), morphine (MM-Mor), or butorphanol (MM-But). The anaesthetic depth and vital signs were monitored at baseline and every 10 min until bats recovered. If after 180 min the bats did not recover, atipamezole was administered. Mean induction times were 7-11.5 min with all combinations. Twitching during induction was common. All combinations produced anaesthesia, with significantly decreased heart rate (from 400 to 200 bpm) and respiratory rate (from 120-140 to 36-65 rpm). Arrhythmia and irregular breathing patterns occurred. MM-Fen, MM-Mor, and MM-But depressed respiration significantly more than MM-Sal. Time to first movement with MM-Ket and MM-But lasted significantly longer than with MM-Sal. Recovery time was significantly shorter in the MM-Sal (88 min) in comparison to all other treatments, and it was significantly longer in the MM-But (159 min), with atipamezole administered to four of the eight bats. In conclusion, all five anaesthetic protocols are suitable for Egyptian fruit bats; MM-Ket produces long anaesthesia and minimal respiratory depression, but cannot be antagonized completely. MM-Fen, MM-Mor, and MM-But depress respiration, but are known to produce good analgesia, and can be fully antagonized. Administration of atipamezole following the use of MM-But in Egyptian fruit bats is recommended.

Cocaine induces state-dependent learning of sexual conditioning in male Japanese quail.

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Gill, Karin E; Rice, Beth Ann; Akins, Chana K

2015-01-01

State dependent learning effects have been widely studied in a variety of drugs of abuse. However, they have yet to be studied in relation to sexual motivation. The current study investigated state-dependent learning effects of cocaine in male Japanese quail (Coturnix japonica) using a sexual conditioning paradigm. Cocaine-induced state-dependent learning effects were investigated using a 2×2 factorial design with training state as one factor and test state as the other factor. During a 14-day training phase, male quail were injected once daily with 10mg/kg cocaine or saline and then placed in a test chamber after 15min. In the test chamber, sexual conditioning trials consisted of presentation of a light conditioned stimulus (CS) followed by sexual reinforcement. During the state dependent test, half of the birds received a shift in drug state from training to testing (Coc→Sal or Sal→Coc) while the other half remained in the same drug state (Coc→Coc or Sal→Sal). Results showed that male quail that were trained and tested in the same state (Coc→Coc or Sal→Sal) showed greater sexual conditioning than male quail that were trained and tested in different states (Sal→Coc) except when cocaine was administered chronically prior to the test (Coc→Sal). For the latter condition, sexual conditioning persisted from cocaine training to the saline test. The findings suggest that state dependent effects may alter sexual motivation and that repeated exposure to cocaine during sexual activity may increase sexual motivation which, in turn, may lead to high risk sexual activities. An alternative explanation for the findings is also discussed. Copyright © 2014 Elsevier Inc. All rights reserved.

Microsatellite loci for dreissenid mussels (Mollusca: Bivalvia: Dreissenidae) and relatives: markers for assessing exotic and native populations.

Science.gov (United States)

Feldheim, Kevin A; Brown, Joshua E; Murphy, Douglas J; Stepien, Carol A

2011-07-01

We developed and tested 14 new polymorphic microsatellite loci for dreissenid mussels, including the two species that have invaded many freshwater habitats in Eurasia and North America, where they cause serious industrial fouling damage and ecological alterations. These new loci will aid our understanding of their genetic patterns in invasive populations as well as throughout their native Ponto-Caspian distributions. Eight new loci for the zebra mussel Dreissena polymorpha polymorpha and six for the quagga mussel D. rostriformis bugensis were compared with new results from six previously published loci to generate a robust molecular toolkit for dreissenid mussels and their relatives. Taxa tested include D. p. polymorpha, D. r. bugensis, D. r. grimmi, D. presbensis, the 'living fossil'Congeria kusceri, and the dark false mussel Mytilopsis leucophaeata (the latter also is invasive). Overall, most of the 24 zebra mussel (N = 583) and 13 quagga mussel (N = 269) population samples conformed to Hardy-Weinberg equilibrium expectations for the new loci following sequential Bonferroni correction. The 11 loci (eight new, three previously published) evaluated for D. p. polymorpha averaged 35.1 alleles and 0.72 mean observed heterozygosity per locus, and 25.3 and 0.75 for the nine loci (six new, three previously published) developed for D. r. bugensis. All but three of these loci successfully amplified the other species of Dreissena, and all but one also amplified Congeria and Mytilopsis. All species and populations tested were significantly divergent using the microsatellite data, with neighbour-joining trees reflecting their evolutionary relationships; our results reveal broad utility for resolving their biogeographic, evolutionary, population and ecological patterns. © 2011 Blackwell Publishing Ltd.

Bis(formylphenolatocobalt(II-Mediated Alternating Radical Copolymerization of tert-Butyl 2-Trifluoromethylacrylate with Vinyl Acetate

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Sanjib Banerjee

2017-12-01

Full Text Available The organometallic-mediated radical polymerization (OMRP of vinyl acetate (VAc and its OMR copolymerization (OMRcoP with tert-butyl 2-trifluoromethylacrylate (MAF-TBE mediated by Co(SAL2 (SAL = 2-formylphenolato or deprotonated salicylaldehyde produced relatively well-defined PVAc and poly(VAc-alt-MAF-TBE copolymers at moderate temperature (<40 °C in bulk. The resulting alternating copolymer was characterized by 1H-, 13C- and 19F-nuclear magnetic resonance (NMR spectroscopies, and by size exclusion chromatography. The linear first-order kinetic plot, the linear evolutions of the molar mass with total monomer conversion, and the relatively low dispersity (Đ~1.55 of the resulting copolymers suggest that this cobalt complex provides some degree of control over the copolymerization of VAc and MAF-TBE. Compared to the previously investigated cobalt complex OMRP mediators having a fully oxygen-based first coordination sphere, this study emphasizes a few peculiarities of Co(SAL2: a lower ability to trap radical chains as compared to Co(acac2 and the absence of catalytic chain transfer reactions, which dominates polymerizations carried in the presence of 9-oxyphenalenone cobalt derivative.

Identification of strains with phenotypes similar to those of Staphylococcus aureus isolated from table chicken eggs using MALDI-TOF MS and genotyping methods

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Marek Agnieszka

2015-06-01

Full Text Available The aim of the study was to identify the affinity of 10 Staphylococcus strains isolated from table chicken eggs to specific species. Preliminary analysis performed by API ID32 Staph test identified these strains as S. aureus, but they exhibited a negative reaction in the tube coagulase test. Thus, the analysed strains were initially characterised as Staphylococcus aureus-like (SAL. Further characterisation was performed by genotypic methods, using restriction fragment length polymorphism (RFLP of the coagulase gene (coa and sequencing of the gene rpoB. An attempt was also made to identify the isolated Staphylococcus strains by MALDI-TOF mass spectrometry. The results indicated that none of the strains tested belonged to the species S. aureus. The rpoB sequences of five isolates showed the highest sequence similarity to S. haemolyticus, three isolates to S. chromogenes, and one isolate to S. epidermidis. One strain (SAL4 remained unidentified in this analysis. The results obtained using mass spectrometry were comparable to those based on gene sequence analysis. Strain SAL4, which could not be identified by sequencing, was identified by MALDI-TOF as Staphylococcus chromogenes.

Salt zone cementing; Cimentacao em zonas de sal

Energy Technology Data Exchange (ETDEWEB)

Santos, Fernando Jose Parente Neiva; Miranda, Cristiane Richard de; Martins, Andre Leibsohn [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

1994-07-01

This work introduces new concepts in the proposal of NaCl concentrations i cement slurry and operational parameters for cementing halite salt zones. Experiments carried out in the laboratory and in the Surface Hydraulic Simulator using real halite coring allowed the determination of halite dissolution rates in relation to flow, contact time, and initial Na Cl concentration in the cement slurries. An experimental procedure was developed to measure the adherence strength of hardened cement on halite formations. A Computer Simulator was developed with the adjustment of a model representing the physical phenomenon of mass transfer to the experimental results obtained, which enable us to calculate the Na Cl concentration profile on cement slurry after its positioning in the well's annular region, as well as the total mass of dissolved salt. Employment of the methodology developed in this work shall reduce risk of collapsed casing as well as the cost of the slurry. (author)

SAL and PVS Model of TTEthernet Synchronization Protocol

Data.gov (United States)

National Aeronautics and Space Administration — Timed-Triggered Ethernet (or TTEthernet)is a communication infrastructure that enables the use of Ethernet in real-time, distributed systems. TTEthernet is...

Salt zone cementing; Cimentacao em zonas de sal

Energy Technology Data Exchange (ETDEWEB)

Santos, Fernando Jose Parente Neiva; Miranda, Cristiane Richard de; Martins, Andre Leibsohn [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

1994-07-01

This work introduces new concepts in the proposal of NaCl concentrations i cement slurry and operational parameters for cementing halite salt zones. Experiments carried out in the laboratory and in the Surface Hydraulic Simulator using real halite coring allowed the determination of halite dissolution rates in relation to flow, contact time, and initial Na Cl concentration in the cement slurries. An experimental procedure was developed to measure the adherence strength of hardened cement on halite formations. A Computer Simulator was developed with the adjustment of a model representing the physical phenomenon of mass transfer to the experimental results obtained, which enable us to calculate the Na Cl concentration profile on cement slurry after its positioning in the well's annular region, as well as the total mass of dissolved salt. Employment of the methodology developed in this work shall reduce risk of collapsed casing as well as the cost of the slurry. (author)

Facilitative Project Management: Constructing A Model For Integrated Change Implementation By Utilizing Case Studies

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Veronica Hodgson

2003-11-01

Die teorie van veranderingsbestuur is omvattend. Organisasies moet op konstante wyse daarby aanpas en dit integreer. In Post-Apartheid Suid-Afrika bou ons tans ’n ras geïntegreerde besigheidsomgewing en gemeenskap, en benut dit maksimaal in ons toetrede tot die mededingende wêreld besigheidsarena. Huidige navorsing het bevind dat die meeste veranderingsinitiatiewe faal weens weerstand teen verandering wat deur swak konseptualisering en beplanning, en ’n gebrek aan behoorlike integrering van mense en die besigheidsdimensies van verandering veroorsaak is. Die model om ’n suksesvolle veranderingsprogram te implementeer, sal ontwerp word met geredelik beskikbare vaardighede en tegnieke. Die ontwikkeling en toetsing sal binne die konteks van drie gevallestudies plaasvind.

Citoquímica de inclusões intranucleares associadas ao vírus do mosaico amarelo do salsão Cytochemical studies of the intranuclear inclusions associated with the celery yellow mosaic virus (CYMV

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Neusa D. da Cruz

1972-01-01

Full Text Available Estudos citoquímicos, ao nível do microscópio óptico, foram efetuados para determinar a natureza química de inclusões intranucleares, de aspecto fibroso, induzidas pelo vírus do mosaico amarelo do salsão na maioria de suas hospedeiras. Os testes citoquímicos foram conduzidos em material foliar fresco ou fixado (aldeído glutárico, Carnoy 3:1 ou Bouin, tendo sido feitas as seguintes reações: hematoxilina férrica (testemunha; Sudan IV e Azul do Nilo (lipídios; iodo-iodeto (amido; Feulgen, Azur B e verde-de-metila-pironina (ácidos nucleicos; ninidrina-Schiff e "Fast Green", este último em soluções ácida e alcalina (proteínas. Os testes com verde-de-metila-pironina, Azur B e ninidrina-Schiff foram combinados com digestão enzimática pela ribonuclease ou pepsina. Os dados obtidos sugerem que, dentro da sensibilidade dos testes realizados, a inclusão contenha proteína, mas não tenha amido, lipídios ou ácidos nucleicos. Isso permite supor, portanto, que essas inclusões não sejam formadas de partículas de vírus.Cytochemical studies at optical microscopic level were made to determine the chemical nature of intranuclear inclusions with fibrous aspect which were induced by the celery yellow mosaic virus (CYMV in most of its hosts. The cytochemical tests were carried on fresh as well on fixed foliar material, fixation being in glutaric aldeid, Carnoy 3:1 or Bouin. The following reactions were tried: ferric haematoxylin (control; Sudan IV and Nile blue (for lipids; iodine ioduret (for starch; Feulgen, azur B and methyl green-pyronin (for nucleic acids; ninhydrin-Schiff and fast-green, the latter in acid and in alcaline solution (for protein. The tests with methyl green-pyronin, azur B and ninhydrin-Schiff were combined with enzimatic digestion with RNase or pepsin. The results suggest that, within the sensibility of the tests, the inclusion contains protein but does not contain starch, lipids or nucleic acids. This permit to

Kalvitis suspends anti-corruption chief over alleged misuse of funds / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2007-01-01

Läti peaminister Aigars Kalvitis algatas uurimise korruptsioonitõrjebüroo direktori Aleksejs Loskutovsi suhtes. Riigikontroll avastas rikkumisi büroo raamatupidamises. Süüdistust on nimetatud ka poliitiliseks rünnakuks

Mass exodus of Latvian politicians promises shake-up in system / Talis Saule Archdeacon

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Archdeacon, Talis Saule

2008-01-01

Vt. samas: Party members drop New Era en masse. Rahulolematusest praeguse valitsuskoalitsiooniga on mitmed Läti poliitikud hüljanud erakonnad, loomaks uut poliitilist jõudu, mis oleks vasakpoolsem võrreldes siiani domineerinud poliitikaga

Effect of histamine H1 and H2 receptor antagonists, microinjected into cerebellar vermis, on emotional memory consolidation in mice

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A.C.L. Gianlorenco

2014-02-01

Full Text Available This study investigated the effects of histamine H1 or H2 receptor antagonists on emotional memory consolidation in mice submitted to the elevated plus maze (EPM. The cerebellar vermis of male mice (Swiss albino was implanted using a cannula guide. Three days after recovery, behavioral tests were performed in the EPM on 2 consecutive days (T1 and T2. Immediately after exposure to the EPM (T1, animals received a microinjection of saline (SAL or the H1 antagonist chlorpheniramine (CPA; 0.016, 0.052, or 0.16 nmol/0.1 µL in Experiment 1, and SAL or the H2 antagonist ranitidine (RA; 0.57, 2.85, or 5.7 nmol/0.1 µL in Experiment 2. Twenty-four hours later, mice were reexposed to the EPM (T2 under the same experimental conditions but they did not receive any injection. Data were analyzed using one-way ANOVA and the Duncan test. In Experiment 1, mice microinjected with SAL and with CPA entered the open arms less often (%OAE and spent less time in the open arms (%OAT in T2, and there was no difference among groups. The results of Experiment 2 demonstrated that the values of %OAE and %OAT in T2 were lower compared to T1 for the groups that were microinjected with SAL and 2.85 nmol/0.1 µL RA. However, when animals were microinjected with 5.7 nmol/0.1 µL RA, they did not show a reduction in %OAE and %OAT. These results demonstrate that CPA did not affect behavior at the doses used in this study, while 5.7 nmol/0.1 µL RA induced impairment of memory consolidation in the EPM.

Characterization of the structure of the Salar de Atacama Basin through gravimetric profiles and interval velocity analysis.

Science.gov (United States)

Becerra, J.; Bascunan, S. A.; Maksymowicz, A.; Martínez, F.; Arriagada, C.

2017-12-01

The structure of the basins found in the Preandean Depression in the northern Central Andes has remained elusive, partly due to a poor understanding of the structural styles and stratigraphy beneath their surface. An independent approach to the multiple interpretations of seismic lines available is the analysis of 2D gravity profiles. An E-W profile was performed across the basin, closely matching the surficial trace of previous seismic lines. The profile shows three gravimetric lows, the most relevant being one beneath the Llano de la Paciencia- Cordillera de la Sal, comprised of deformed evaporitic and terrigenous deposits of Oligocene-Early Miocene age. The structure which bounds this gravity low has a steeper dip on its eastern side, bounding the eastern side of the Cordillera de la Sal, which is at odds with previous studies that interpreted its western contact with Cretaceous outcrops as the possible basin boundary. The 3-D analyses of seismic interval velocity data around the gravimetric survey reveal a major vertical contrast in the eastern portion of the profile, interpreted as the bottom of the evaporite successions, followed to the west by a complex, narrow and deep zone of low velocities. Westward, the Cretaceous rocks record higher velocities than its post-Paleocene counterparts, and an almost uniform increase in velocity with depth. The major gravity anomaly is closely related to the Cordillera de la Sal, which consists of an array of folds and reverse faults involving Oligocene to recent deposits. We propose that the faults which generated Oligocene extension are not at the western border of the basin, but around the Cordillera de la Sal, which is the result of Miocene inversion of the same system. Strike-slip deformation was also probably a major contributor in basin formation, as shown by the narrow yet deep shape of the depocenter.

Effect of histamine H1 and H2 receptor antagonists, microinjected into cerebellar vermis, on emotional memory consolidation in mice

International Nuclear Information System (INIS)

Gianlorenço, A.C.L.; Serafim, K.R.; Canto-de-Souza, A.; Mattioli, R.

2014-01-01

This study investigated the effects of histamine H1 or H2 receptor antagonists on emotional memory consolidation in mice submitted to the elevated plus maze (EPM). The cerebellar vermis of male mice (Swiss albino) was implanted using a cannula guide. Three days after recovery, behavioral tests were performed in the EPM on 2 consecutive days (T1 and T2). Immediately after exposure to the EPM (T1), animals received a microinjection of saline (SAL) or the H1 antagonist chlorpheniramine (CPA; 0.016, 0.052, or 0.16 nmol/0.1 µL) in Experiment 1, and SAL or the H2 antagonist ranitidine (RA; 0.57, 2.85, or 5.7 nmol/0.1 µL) in Experiment 2. Twenty-four hours later, mice were reexposed to the EPM (T2) under the same experimental conditions but they did not receive any injection. Data were analyzed using one-way ANOVA and the Duncan test. In Experiment 1, mice microinjected with SAL and with CPA entered the open arms less often (%OAE) and spent less time in the open arms (%OAT) in T2, and there was no difference among groups. The results of Experiment 2 demonstrated that the values of %OAE and %OAT in T2 were lower compared to T1 for the groups that were microinjected with SAL and 2.85 nmol/0.1 µL RA. However, when animals were microinjected with 5.7 nmol/0.1 µL RA, they did not show a reduction in %OAE and %OAT. These results demonstrate that CPA did not affect behavior at the doses used in this study, while 5.7 nmol/0.1 µL RA induced impairment of memory consolidation in the EPM

Effect of histamine H1 and H2 receptor antagonists, microinjected into cerebellar vermis, on emotional memory consolidation in mice

Energy Technology Data Exchange (ETDEWEB)

Gianlorenço, A.C.L.; Serafim, K.R. [Laboratório de Neurociências, Departamento de Fisioterapia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, SP, Brasil, Laboratório de Neurociências, Departamento de Fisioterapia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, SP (Brazil); Canto-de-Souza, A. [Laboratório de Psicologia da Aprendizagem, Departamento de Psicologia, Centro de Educação e Ciências Humanas, Universidade Federal de São Carlos, São Carlos, SP, Brasil, Laboratório de Psicologia da Aprendizagem, Departamento de Psicologia, Centro de Educação e Ciências Humanas, Universidade Federal de São Carlos, São Carlos, SP (Brazil); Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos, SP, Brasil, Programa de Pós-Graduação em Ciências Fisiológicas, Universidade Federal de São Carlos, São Carlos, SP (Brazil); Instituto de Neurociências e Comportamento, Universidade de São Paulo, Ribeirão Preto, SP, Brasil, Instituto de Neurociências e Comportamento, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Mattioli, R. [Laboratório de Neurociências, Departamento de Fisioterapia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, SP, Brasil, Laboratório de Neurociências, Departamento de Fisioterapia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, SP (Brazil)

2014-02-17

This study investigated the effects of histamine H1 or H2 receptor antagonists on emotional memory consolidation in mice submitted to the elevated plus maze (EPM). The cerebellar vermis of male mice (Swiss albino) was implanted using a cannula guide. Three days after recovery, behavioral tests were performed in the EPM on 2 consecutive days (T1 and T2). Immediately after exposure to the EPM (T1), animals received a microinjection of saline (SAL) or the H1 antagonist chlorpheniramine (CPA; 0.016, 0.052, or 0.16 nmol/0.1 µL) in Experiment 1, and SAL or the H2 antagonist ranitidine (RA; 0.57, 2.85, or 5.7 nmol/0.1 µL) in Experiment 2. Twenty-four hours later, mice were reexposed to the EPM (T2) under the same experimental conditions but they did not receive any injection. Data were analyzed using one-way ANOVA and the Duncan test. In Experiment 1, mice microinjected with SAL and with CPA entered the open arms less often (%OAE) and spent less time in the open arms (%OAT) in T2, and there was no difference among groups. The results of Experiment 2 demonstrated that the values of %OAE and %OAT in T2 were lower compared to T1 for the groups that were microinjected with SAL and 2.85 nmol/0.1 µL RA. However, when animals were microinjected with 5.7 nmol/0.1 µL RA, they did not show a reduction in %OAE and %OAT. These results demonstrate that CPA did not affect behavior at the doses used in this study, while 5.7 nmol/0.1 µL RA induced impairment of memory consolidation in the EPM.

Stakeholders' Perceptions Sought to Inform the Development of a Low-Cost Mobile Robot for Older Adults: A Qualitative Descriptive Study.

Science.gov (United States)

Sefcik, Justine S; Johnson, Michelle J; Yim, Mark; Lau, Tessa; Vivio, Nicholas; Mucchiani, Caio; Cacchione, Pamela Z

2018-02-01

Creative solutions are needed to support community-dwelling older adults residing in a variety of settings including their house, apartment, or Supportive Apartment Living (SAL) to promote independence and reduce the risk of nursing home replacement. The objective of this study was to gain an understanding of older adults' needs for physical, mental, and social activities to support the design and functionality of a low-cost mobile assistive robot. A qualitative descriptive study was designed which included three stakeholder focus groups (caregivers, clinicians, and older adults). We held three focus groups with a total of 19 participants: one with paid caregivers ( n = 6), one with interdisciplinary clinicians ( n = 8), and one with older adults residing in SAL ( n = 5). Conventional content analysis was the analytical technique. Four themes emerged: (a) Accomplishing Everyday Tasks: activities of daily living (ADLs) and instrumental activities of daily living (IADLs) were important from the perspectives of all three groups for the older adults to accomplish daily, as well as the "use it or lose it" attitude of the older adults; (b) Personal Connections and Meaningful Activities: for the older adults, it was important for them to engage in socialization and leisure activities, and for the caregivers and clinicians, they work to build personal relationships with the older adults; (c) Cognitive Interventions: the clinicians provided cognitive tools (including reminders, routine and designing interventions) to older adults so they can remain as safe and independent as possible in the SAL; and (d) Safety Measures: encompassed clinicians addressing safety and injury prevention and the caregivers checking in on the older adults in their SAL apartments. This work contributed to the design and functionality specifications for an autonomous low-cost mobile robot for deployment to increase the independence of older adults.

Involvement of β3-adrenergic receptors in the control of food intake in rats.

Science.gov (United States)

Kanzler, S A; Januario, A C; Paschoalini, M A

2011-11-01

This study examined the food intake changes evoked by intracerebroventricular (icv) injection of a selective agonist (BRL37344, 2 and 20 nmol) or antagonist (SR59230A, 10 and 50 nmol) of β3-adrenergic receptors in 24-h fasted rats (adult male Wistar rats, 200-350 g, N = 6/treatment). The animals were also pretreated with saline icv (SAL) or SR59230A (50 nmol) followed by BRL37344 (20 nmol) or SAL in order to determine the selectivity of the effects evoked by BRL37344 on food intake or the selectivity of the effects evoked by SR59230A on risk assessment (RA) behavior. The highest dose of BRL37344 (N = 7) decreased food intake 1 h after the treatment (6.4 ± 0.5 g in SAL-treated vs 4.2 ± 0.8 g in drug-treated rats). While both doses of SR59230A failed to affect food intake (5.1 ± 1.1 g for 10 nmol and 6.0 ± 1.8 g for 50 nmol), this treatment reduced the RA frequency (number/30 min) (4 ± 2 for SAL-treated vs 1 ± 1 for 10 nmol and 0.5 ± 1 for 50 nmol SR59230A-treated rats), an ethological parameter related to anxiety. While pretreatment with SR59230A (7.0 ± 0.5 g) abolished the hypophagia induced by BRL37344 (3.6 ± 0.9 g), BRL37344 suppressed the reduction in RA frequency caused by SR59230A. These results show that the hypophagia caused by BRL37344 is selectively mediated by β3-adrenergic receptors within the central nervous system. Moreover, they suggest the involvement of these receptors in the control of anxiety.

Involvement of β3-adrenergic receptors in the control of food intake in rats

Directory of Open Access Journals (Sweden)

S.A. Kanzler

2011-11-01

Full Text Available This study examined the food intake changes evoked by intracerebroventricular (icv injection of a selective agonist (BRL37344, 2 and 20 nmol or antagonist (SR59230A, 10 and 50 nmol of β3-adrenergic receptors in 24-h fasted rats (adult male Wistar rats, 200-350 g, N = 6/treatment. The animals were also pretreated with saline icv (SAL or SR59230A (50 nmol followed by BRL37344 (20 nmol or SAL in order to determine the selectivity of the effects evoked by BRL37344 on food intake or the selectivity of the effects evoked by SR59230A on risk assessment (RA behavior. The highest dose of BRL37344 (N = 7 decreased food intake 1 h after the treatment (6.4 ± 0.5 g in SAL-treated vs 4.2 ± 0.8 g in drug-treated rats. While both doses of SR59230A failed to affect food intake (5.1 ± 1.1 g for 10 nmol and 6.0 ± 1.8 g for 50 nmol, this treatment reduced the RA frequency (number/30 min (4 ± 2 for SAL-treated vs 1 ± 1 for 10 nmol and 0.5 ± 1 for 50 nmol SR59230A-treated rats, an ethological parameter related to anxiety. While pretreatment with SR59230A (7.0 ± 0.5 g abolished the hypophagia induced by BRL37344 (3.6 ± 0.9 g, BRL37344 suppressed the reduction in RA frequency caused by SR59230A. These results show that the hypophagia caused by BRL37344 is selectively mediated by β3-adrenergic receptors within the central nervous system. Moreover, they suggest the involvement of these receptors in the control of anxiety.

Sertraline inhibits formalin-induced nociception and cardiovascular responses

Energy Technology Data Exchange (ETDEWEB)

Santuzzi, C.H. [Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES (Brazil); Futuro Neto, H.A. [Departamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES (Brazil); Escola de Medicina da Empresa Brasileira de Ensino, Pesquisa e Extensão, Vitória, ES (Brazil); Escola Superior de Ciências da Saúde, Santa Casa de Misericórdia de Vitória, Vitória, ES (Brazil); Pires, J.G.P. [Escola de Medicina da Empresa Brasileira de Ensino, Pesquisa e Extensão, Vitória, ES (Brazil); Centro Universitário do Espírito Santo, Colatina, ES (Brazil); Gonçalves, W.L.S. [Centro Universitário do Espírito Santo, Colatina, ES (Brazil); Tiradentes, R.V.; Gouvea, S.A.; Abreu, G.R. [Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES (Brazil)

2011-11-18

The objective of the present study was to determine the antihyperalgesic effect of sertraline, measured indirectly by the changes of sciatic afferent nerve activity, and its effects on cardiorespiratory parameters, using the model of formalin-induced inflammatory nociception in anesthetized rats. Serum serotonin (5-HT) levels were measured in order to test their correlation with the analgesic effect. Male Wistar rats (250-300 g) were divided into 4 groups (N = 8 per group): sertraline-treated group (Sert + Saline (Sal) and Sert + Formalin (Form); 3 mg·kg{sup −1}·day{sup −1}, ip, for 7 days) and saline-treated group (Sal + Sal and Sal + Form). The rats were injected with 5% (50 µL) formalin or saline into the right hind paw. Sciatic nerve activity was recorded using a silver electrode connected to a NeuroLog apparatus, and cardiopulmonary parameters (mean arterial pressure, heart rate and respiratory frequency), assessed after arterial cannulation and tracheotomy, were monitored using a Data Acquisition System. Blood samples were collected from the animals and serum 5-HT levels were determined by ELISA. Formalin injection induced the following changes: sciatic afferent nerve activity (+50.8 ± 14.7%), mean arterial pressure (+1.4 ± 3 mmHg), heart rate (+13 ± 6.8 bpm), respiratory frequency (+4.6 ± 5 cpm) and serum 5-HT increased to 1162 ± 124.6 ng/mL. Treatment with sertraline significantly reduced all these parameters (respectively: +19.8 ± 6.9%, -3.3 ± 2 mmHg, -13.1 ± 10.8 bpm, -9.8 ± 5.7 cpm) and serum 5-HT level dropped to 634 ± 69 ng/mL (P < 0.05). These results suggest that sertraline plays an analgesic role in formalin-induced nociception probably through a serotonergic mechanism.

Does the survival motor neuron copy number variation play a role in the onset and severity of sporadic amyotrophic lateral sclerosis in Malians?

Science.gov (United States)

Sangare, Modibo; Dicko, Ilo; Guinto, Cheick Oumar; Sissoko, Adama; Dembele, Kekouta; Coulibaly, Youlouza; Coulibaly, Siaka Y; Landoure, Guida; Diallo, Abdallah; Dolo, Mamadou; Dolo, Housseini; Maiga, Boubacar; Traore, Moussa; Karembe, Mamadou; Traore, Kadiatou; Toure, Amadou; Sylla, Mariam; Togora, Arouna; Coulibaly, Souleymane; Traore, Sékou Fantamady; Hendrickson, Brant; Bricceno, Katherine; Schindler, Alice B; Kokkinis, Angela; Meilleur, Katherine G; Sangho, Hammadoun Ali; Diakite, Brehima; Kassogue, Yaya; Coulibaly, Yaya Ibrahim; Burnett, Barrington; Maiga, Youssoufa; Doumbia, Seydou; Fischbeck, Kenneth H

2016-06-01

Spinal muscular atrophy (SMA) and sporadic amyotrophic lateral sclerosis (SALS) are both motor neuron disorders. SMA results from the deletion of the survival motor neuron ( SMN ) 1 gene. High or low SMN1 copy number and the absence of SMN2 have been reported as risk factors for the development or severity of SALS. To investigate the role of SMN gene copy number in the onset and severity of SALS in Malians. We determined the SMN1 and SMN2 copy number in genomic DNA samples from 391 Malian adult volunteers, 120 Yoruba from Nigeria, 120 Luyha from Kenya and 74 U.S. Caucasians using a Taqman quantitative PCR assay. We evaluated the SALS risk based on the estimated SMA protein level using the Veldink formula ( SMN1 copy number + 0.2 ∗  SMN2 copy number). We also characterized the disease natural history in 15 ALS patients at the teaching hospital of Point G, Bamako, Mali. We found that 131 of 391 (33.5%) had an estimated SMN protein expression of ≤ 2.2; 60 out of 391 (15.3%) had an estimated SMN protein expression < 2 and would be at risk of ALS and the disease onset was as early as 16 years old. All 15 patients were male and some were physically handicapped within 1-2 years in the disease course. Because of the short survival time of our patients, family histories and sample DNA for testing were not done. However, our results show that sporadic ALS is of earlier onset and shorter survival time as compared to patients elsewhere. We plan to establish a network of neurologists and researchers for early screening of ALS.

Synonymy in the Translation Equivalent Paradigms of a Standard Translation Dictionary

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Phillip Adriaan Louw

2012-09-01

vertaalekwivalentparadigmas van 'n standaard vertalende woordeboek

Die norm in die huidige kanonieke vertalende woordeboeke met Afrikaans en Engels as die behandelde taalpaar is 'n ongediskrimineerde lysting van gedeeltelik sinonieme vertaalekwivalente. Hulle word deur kommas as die enigste merkers van sinonimiteit geskei. Leksikograwe behoort hierdie praktyk te verwerp en die siening te aanvaar dat absolute sinonieme net so skaars is as absolute ekwivalente. In die meeste gevalle sal lede van 'n doeltaalsinoniemparadigma gedeeltelike sinonieme wees wat die een of ander konteksleiding benodig om hulle van die ander lede van die paradigma te onderskei.

Hierdie artikel sal op die motivering vir die aanduiding van gedeeltelike doeltaalsinonimie fokus. Twee spesifieke motiverings sal bespreek word asook wyses waarop ekwivalentdiskriminasie geïmplementeer kan word.

Die eerste motivering is die gevolg van 'n groep problematiese verskynsels wat kontekstuele divergensie tussen die bron- en doeltaal veroorsaak. Stilistiese en registerdivergensie behoort konteksleiding te noodsaak. Leksikografiese etikette is die diskriminators wat die frekwentste gebruik word, maar in Suid-Afrikaanse woordeboeke word hulle te min en te inkonsekwent aangewend. Ander moontlike diskriminators sal ook bespreek word.

Die mees problematiese motivering vir die aanduiding van gedeeltelike sinonimie is egter verskillende vertaalekwivalente vir verskillende gebruike van 'n lemma. Wyses waarop ekwivalentdiskriminasie by hierdie gevalle geïmplementeer kan word, sal in detail bespreek word.

Laastens sal aangetoon word dat geen van die groot veranderings wat bepleit word, vrugte sal dra sonder 'n nuwe, meer effektiewe metode om sinonieme te merk en te orden nie.

Sleutelwoorde: absolute sinonimie; betekenisonderskeidings; doeltaalsinonieme; doeltaalsinoniemparadigma; ekwivalentdiskriminasie; gebruike van die lemma; gedeeltelike sinonimie; konteksleiding; leksikografiese etikette; polisemie

Detection of anti-HIV-1 IgG antibodies in whole saliva by GACELISA and Western blot assays.

Science.gov (United States)

Matee, M I; Lyamuya, E F; Simon, E; Mbena, E C; Kagoma, C; Samaranayake, L P; Scheutz, F

1996-05-01

The present study, based on 158 HIV seropositives and 167 HIV seronegatives, demonstrates that saliva collected with the Omni-SAL device and tested with GACELISA (an IgG antibody capture ELISA) is an effective non-invasive alternative to serum for anti-HIV IgG antibody screening. The study also shows that a conventional serum Western blot kit can be used, with slight modifications, for confirmatory testing of saliva specimens. Collecting saliva with the Omni-SAL device had a very good acceptance rate among Tanzanian subjects, and although this diagnostic method is not yet known by the general public, 65% of the study participants preferred to give saliva instead of blood for HIV testing.

Research of radiation technology in keeping pet feed fresh

International Nuclear Information System (INIS)

Lin Qin; Zhang Tongcheng; Liu Qingfang; Wang Chunlei

2002-01-01

Objective: To find a effective, simple, quick method of radiation keeping fresh technology. Method: To detect the number of bacterium colony and pathogen and D 10 in Raschide dog chews firstly, then calculate them with the formulate of S D = D 10 log N 0 /SAL. Result: The total number of bacterium colony and pathogen in Raschide dog chews, a kind of pet feed, were detected. The mean total number of colony forming units was 3980 every gram and G + bacilli predominant, cocci less. The D 10 value of G + bacilli was 1.51 KGy. Conclusion: According to the certain formula method, the product SAL can be kept at 10 -6 level with 14.50 KGy radiation dose

Fontes de lipídeos e monensina na alimentação de novilhos Nelore e sua relação com a população de protozoários ciliados do rúmen

OpenAIRE

Valinote,Amaury Camilo; Nogueira Filho,José Carlos Machado; Leme,Paulo Roberto; Silva,Saulo da Luz e; Cunha,José Aparecido

2005-01-01

Quatro novilhos Nelore, fistulados e canulados no rúmen, foram distribuídos em um delineamento quadrado latino 4 x 4, para avaliar o caroço de algodão e o sal de cálcio de ácidos graxos como fontes de gordura assim como o efeito da monensina em dietas com caroço de algodão, sobre a população de protozoários ciliados e o pH do rúmen. Os tratamentos experimentais foram: dieta controle (CTRL), dieta com sal de cálcio de ácidos graxos (SC), dieta com caroço de algodão (CA) e dieta com caroço de a...

The activities of the IAEA Laboratories, Vienna. Annual report 1981

International Nuclear Information System (INIS)

Taylor, C.B.G.

1983-06-01

The report presents the activities of the IAEA Laboratories at Seibersdorf during the year 1981, with emphasis on the twofold purpose of the Laboratories: to support the Technical Cooperation activities of the Agency, and to operate the Safeguards Analytical Laboratory (SAL). The section dealing with the IAEA Technical Cooperation reports the programs of research where methods developed in Vienna are used throughout the world. Another section deals with the advanced techniques for chemical analysis and the interlaboratory comparisons programme. The training of specialists from member states is also described. The SAL, which became a separate part of the Laboratory, and its role in the Agency's Safeguards programme is also described. Reports and publications of Laboratory members are also listed

Jogando com as feminilidades: um estudo etnográfico em um time de futsal feminino de Porto Alegre Jugando con las feminidades: um estudio etnográfico en un equipo de fútbol de salón femenino de Porto Alegre Laying with femininity: ethnographic study on an indoor soccer team from Porto Alegre

Directory of Open Access Journals (Sweden)

Raquel da Silveira

2013-03-01

Full Text Available Esse estudo aborda o associativismo esportivo de mulheres. Trata-se de uma investigação etnográfica desenvolvida no contexto de um time de futsal feminino, onde procuramos saber como e porque mulheres se associam para praticar um esporte socialmente considerado masculino, e como essa prática se insere nas suas vidas. Após um ano de observação participante (diários de campo e realização de entrevistas (17, identificamos que a prática do futsal extrapola o jogo propriamente dito, sendo fortemente vinculada a questões de gênero e sexualidade presentes dentro e fora da quadra. Na relação com o esporte que elas escolheram praticar, esses temas se entrelaçavam no cotidiano das jogadoras, de forma heterogênea: se, por um lado, identificamos uma transgressão em relação aos padrões dominantes, por outro, também visualizamos a reprodução desses mesmos valores.Este estudio aborda el asociativismo deportivo de mujeres. Se trata de una investigación etnográfica desarrollada en el contexto de un equipo de fútbol de salón femenino, donde buscamos saber cómo y por qué mujeres se asocian para prácticar un deporte socialmente considerado masculino, y como esa práctica se inserta en sus vidas. Después de un año de observación participante (diarios de campo y realización de entrevistas (17, identificamos que la práctica de fútbol de salón extrapola el juego propiamente dicho, siendo vinculada a las cuestiones de género y sexualidad presentes dentro y afuera de la cancha. En la relación con el deporte que ellas eligieron prácticar, eses temas se entrelazaban en el cotidiano de las jugadoras de forma heterogénea: si por un lado, identificamos una transgresión en relación a los padrones dominantes, por otro, también visualizamos la reproducción de esos mismos valores.This study approaches the sporting associativism of women. It is an ethnographic investigation developed in the context of a female indoor soccer team, in

Automated Laser Seeker Performance Evaluation System (ALSPES)

Data.gov (United States)

Federal Laboratory Consortium — This facility provides complete open-loop test capability for semi-active laser (SAL) seekers/sensors operating at 1.064 microns. ALSPES provides characterizations...

Exploring Dust Impacts on Tropical Systems from the NASA HS-3 Field Campaign

Science.gov (United States)

Nowottnick, Ed; Colarco, Pete; da Silva, Arlindo; Barahona, Donifan; Hlavka, Dennis

2015-01-01

One of the overall scientific goals of the NASA Hurricane and Severe Storm Sentinel (HS-3) field campaign is to better understand the role of the Saharan Air Layer (SAL) in tropical storm development. During the 2012 HS-3 deployment, the Cloud Physics Lidar (CPL) observed dust within SAL air in close proximity to a developing Nadine (September 11, 2012). Throughout the mission, the NASA GEOS-5 modeling system supported HS-3 by providing 0.25 degrees resolution 5-day global forecasts of aerosols, which were used to support mission planning. The aerosol module was radiatively interactive within the GEOS-5 model, but aerosols were not directly coupled to cloud and precipitation processes. In this study we revisit the aerosol forecasts with an updated version of the GEOS-5 model. For the duration of Hurricane Nadine, we run multiday climate simulations leading up to each respective Global Hawk flight with and without aerosol direct interaction. For each set of simulations, we compare simulated dust mass fluxes to identify differences in SAL entrainment related to the interaction between dust aerosols and the atmosphere. We find that the direct effects of dust induce a low level anticyclonic circulation that temporarily shields Nadine from the intrusion of dry air, leading to a more intense storm.

Live performance and processing yields of broilers fed diets with tiamulin and salinomycin combinations

Directory of Open Access Journals (Sweden)

SL Vieira

2010-03-01

Full Text Available A study was conducted with the objective of evaluating the combined application of tiamulin (TIA and salinomycin (SAL in broiler diets fed from 1 to 42 d of age. One thousand and two hundred Cobb x Cobb 500 male broilers were housed in 48 floor pens and fed corn-soybean meal diets containing 66 ppm of SAL combined or not with TIA at 30 or 20 and 20 or 15 ppm, respectively, in the starter (1-21 d and grower feeds (22-42 d; however, TIA was withdrawn from the feeds 7 days before slaughter. The experimental design was completely randomized with 3 treatments and 16 replicates of 25 birds each. Broilers were weekly evaluated for live performance whereas carcass yield, abdominal fat and commercial cuts were assessed at 42 d using 6 birds randomly taken from each pen. Results obtained at the end of the study demonstrated that body weight gain was not affected (P > 0.05 by the treatments, whereas feed intake was reduced (P 0.05 by the treatments. Live performance and post-slaughter yields data obtained in this study did not indicate that combinations of TIA with SAL could be detrimental. In fact, an improvement in feed conversion was observed at the lowest dose of TIA.

Impact of tropical cyclone Matmo on mixed zone of the Yellow and Bohai seas

Science.gov (United States)

Guo, Jie; Ji, Diansheng; Hou, Chawei; Guo, Kai; Ji, Ling

2017-12-01

The Bohai Sea is a low-lying semi-enclosed sea area that is linked to the Yellow Sea via the Bohai straits (mixed zone). Its off shore seabed is shallow, which makes it vulnerable to serious marine meteorological disasters associated with the northward passage of Pacifi c tropical cyclones. Analyses on data of remote sensing and buoy of the mixed zone of the Yellow and Bohai seas indicate that all the wind speed, signifi cant wave height, and salinity (SAL) increased, sea surface temperature decreased, and wind energy density changed considerably during the passage of tropical cyclone Matmo on July 25, 2014. It was found that the SAL inversion layer in the mixed zone of the Yellow and Bohai Seas was caused by the tropical cyclone. Furthermore, it was found that the tropical cyclone transported the northern Yellow Sea cold water mass (NYSCWM) into the mixed zone of the Yellow and Bohai Seas. The NYSCWM has direct infl uence on both the aquaculture and the ecological environment of the region. Therefore, further research is needed to establish the mechanism behind the formation of the SAL inversion layer in the mixed zone, and to determine the infl uence of tropical cyclones on the NYSCWM.

Divergent trend in density versus viscosity of ionic liquid/water mixtures: a molecular view from guanidinium ionic liquids.

Science.gov (United States)

Singh, Akhil Pratap; Gardas, Ramesh L; Senapati, Sanjib

2015-10-14

Ionic liquids (ILs) have shown great potential in the dissolution and stability of biomolecules when a low-to-moderate quantity of water is added. Hence, determining the thermophysical properties and understanding these novel mixtures at the molecular level are of both fundamental and practical importance. In this context, here we report the synthesis of two nontoxic guanidinium cation based ILs, tetramethylguanidinium benzoate [TMG][BEN] and tetramethylguanidinium salicylate [TMG][SAL], and present a detailed comparison of their thermophysical properties in the presence of water. The results show that the [TMG][SAL]/water mixtures have higher density and higher apparent molar volume, but a lower viscosity and higher compressibility than the [TNG][BEN]/water mixtures. The measured viscosity and compressibility data are explained from ab initio quantum mechanical calculations and liquid-phase molecular dynamics simulations, where salicylate anions of denser [TMG][SAL]/water were found to exist as isolated ions due to intramolecular H-bonding. On the contrary, intermolecular H-bonding among the benzoate anions and their strong tendency to form an extended H-bonding network with water made [TMG][BEN]/water solutions more viscous and less compressible. This study shows the importance of probing these emerging solvents at the molecular-to-atomic level, which could be helpful in their optimal usage for task-specific applications.

C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosis.

Science.gov (United States)

He, Ji; Tang, Lu; Benyamin, Beben; Shah, Sonia; Hemani, Gib; Liu, Rong; Ye, Shan; Liu, Xiaolu; Ma, Yan; Zhang, Huagang; Cremin, Katie; Leo, Paul; Wray, Naomi R; Visscher, Peter M; Xu, Huji; Brown, Matthew A; Bartlett, Perry F; Mangelsdorf, Marie; Fan, Dongsheng

2015-09-01

A hexanucleotide repeat expansion (HRE) in the C9orf72 gene has been identified as the most common mutation in amyotrophic lateral sclerosis (ALS) among Caucasian populations. We sought to comprehensively evaluate genetic and epigenetic variants of C9orf72 and the contribution of the HRE in Chinese ALS cases. We performed fragment-length and repeat-primed polymerase chain reaction to determine GGGGCC copy number and expansion within the C9orf72 gene in 1092 sporadic ALS (sALS) and 1062 controls from China. We performed haplotype analysis of 23 single-nucleotide polymorphisms within and surrounding C9orf72. The C9orf72 HRE was found in 3 sALS patients (0.3%) but not in control subjects (p = 0.25). For 2 of the cases with the HRE, genotypes of 8 single-nucleotide polymorphisms flanking the HRE were inconsistent with the haplotype reported to be strongly associated with ALS in Caucasian populations. For these 2 individuals, we found hypermethylation of the CpG island upstream of the repeat, an observation not detected in other sALS patients (p HRE were highly associated with repeat lengths >8 repeats implying that both haplotypes may confer instability of repeat length. Copyright © 2015 Elsevier Inc. All rights reserved.

Considerations for Providing Etymological Information in the Advanced Ndebele Dictionary

Directory of Open Access Journals (Sweden)

Langa Khumalo

2011-10-01

Full Text Available

Abstract: This article discusses the presentation of etymological information in the prospective Advanced Ndebele Dictionary (henceforth the AND which is still in its planning stage. The AND will be a successor to Isichazamazwi SesiNdebele (henceforth the ISN, a medium-sized, general-purpose, monolingual Ndebele dictionary published in 2001. The AND will not just be larger than the ISN, but will be more advanced with regard to the depth and scope of its lexical items and definitions. Whereas the ISN was based on a corpus size of about a million running words, the AND is envisaged to have as basis a corpus size of about five million. To this end, corpus expansion is an ongoing process. Again, unlike its forerunner, the AND will provide additional grammatical information for ach lexical item, including phonetic transcription, tone marking and etymology. It is the inclusion of etymological information in the AND that is critically examined in this article. There is a long tradition of providing etymological information in modern dictionaries from Oxford's New English Dictionary to ALRI's Duramazwi Guru reChiShona.

Keywords: ETYMOLOGY, ADVANCED NDEBELE DICTIONARY, CULTURE, HERITAGE, LANGUAGE CONTACT

Opsomming: Oorwegings vir die verskaffing van etimologiese inligting in die Gevorderde Ndebelewoordeboek. Hierdie artikel bespreek die aanbieding van etimo-logiese inligting in die toekomstige Gevorderde Ndebelewoordeboek (voortaan die GNW wat nog in sy beplanningstadium is. Die GNW sal 'n opvolger wees van die Isichazamazwi SesiNdebele (voortaan die ISN, 'n middelgroot, meerdoelige, eentalige Ndebelewoordeboek wat in 2001 gepubliseer is. Die GNW sal nie net groter as die ISN wees nie, maar sal meer gevorderd wees wat betref die diepte en omvang van sy leksikale items en definisies. Waar die ISN gebaseer was op 'n korpus-grootte van ongeveer 'n miljoen woordoptekeninge, word voorsien dat die GNW 'n korpusgrootte van ongeveer vyf miljoen as

Uued plaadid

Index Scriptorium Estoniae

1999-01-01

Uutest heliplaatidest Ivo Linna & Rock Hotel "Kõva ketas", Hendrik Sal-Saller "1994-1996", Chemical Brothers "Surrender", Mike & The Mechanics "M6", Bomfunk Mc"s "In Stereo", Jamiroquai "Synkronized"

Biocontrol potential of salinity tolerant mutants of Trichoderma harzianum against Fusarium oxysporum Potencial de biocontrole de mutantes sal-tolerantes de Trichoderma harzianum contra Fusarium oxysporum

Directory of Open Access Journals (Sweden)

Hassan Abdel-Latif A. Mohamed

2006-06-01

Full Text Available Exposing a wild-type culture of Trichoderma harzianum to gamma irradiation induced two stable salt-tolerant mutants (Th50M6 and Th50M11. Under saline conditions, both mutants greatly surpassed their wild type strain in growth rate, sporulation and biological proficiency against Fusarium oxysporum, the causal agent of tomato wilt disease. Tolerant T. harzianum mutants detained a capability to grow and convinced sporulation in growth media containing up to 69 mM NaCl. In comparison with their parent strain, characterization of both mutants confirmed that they have reinforced contents of proline and hydroxyproline, relatively higher sodium content compared to potassium, calcium or magnesium contents, higher level of total phenols. Electrophoretic analysis of total soluble proteins in the salt tolerance mutant Th50M6 showed different bands accumulated in response to 69 mM NaCl. Data also showed that mutants produce certain active metabolites, such as chitinases, cellulases, beta-galactosidases, as well as, some antibiotics i.e., trichodermin, gliotoxin and gliovirin. Trichoderma mutants significantly reduced wilt disease incidence and improved yield and mineral contents of tomato plants under both saline and non-saline soil conditions, as well as, under infested and natural conditions. T. harzianum mutants were also more efficient in dropping the F. oxysporum growth in rhizosphere compared to the wild type strain. Population density of both mutants in rhizosphere far exceeded that of T. harzianum wild type strain.A exposição de uma cepa selvagem de Trichoderma harzianum à irradiação gama induziu dois mutantes tolerantes a sal (Th50M6 e Th50M11. Em condições salinas, os dois mutantes foram muito superiores à cepa selvagem em relação à velocidade de multiplicação, esporulação e eficiência contra Fusarium oxysporum, o agente causador da doença wilt do tomate. Os mutantes tolerantes foram capazes de multiplicação e esporulação em

Cape Verde - WASH and Land Management for Investment Project Survey

Data.gov (United States)

Millennium Challenge Corporation — The overall objective of this survey is to collect relevant information on water, sanitation and hygiene sectors in Praia, hinterlands of Santiago and Sal Islands....

Cinética e equilíbrio de adsorção dos oxiânions Cr (VI, Mo (VI e Se (VI pelo sal de amônio quaternário de quitosana Kinetics and equilibrium of adsorption of oxyanions Cr (VI, Mo (VI and Se (VI by quaternary ammonium chitosan salt

Directory of Open Access Journals (Sweden)

Viviane A. Spinelli

2005-07-01

Full Text Available O sal quaternário de quitosana foi sintetizado com cloreto de glicidil trimetil amônio. A modificação química foi caracterizada por espectrometria no IV, RMN de 13C e ¹H, e mmol/g de grupos quaternários presentes na matriz polimérica por condutimetria. A remoção de Cr (VI, Mo (VI e Se (VI, em meio aquoso, foi investigada em processo de batelada. A adsorção mostrou ser dependente do pH para o Cr (VI e Se (VI, com um pH ótimo de adsorção, entre 4,0 a 6,0. Para o Mo (VI a adsorção manteve-se quase constante no intervalo de pH entre 4,0 e 11,5. O modelo de isoterma de Langmuir descreveu melhor os dados de equilíbrio na faixa de concentração investigada. No presente estudo, um grama do sal quaternário de quitosana reticulado com glutaraldeído adsorveu 68,3 mg de Cr, 63,4 mg de Mo e 90,0 mg de Se. A velocidade de adsorção, no processo, segue a equação cinética de pseudo segunda-ordem, sendo que o equilíbrio para os três íons foi alcançado próximo aos 200 minutos. A análise dispersiva de raios-X para o Cr (VI mostrou que o principal mecanismo de adsorção é a troca iônica entre os íons Cl- da superfície do polímero pelos oxiânions. O trocador aniônico apresentou a seguinte ordem de seletividade: Cr (VI > Mo (VI > Se (VI.Quaternary chitosan salt was synthesized in the presence of glycidyl trimetyl ammonium chloride. The polymer was characterized by spectroscopic techniques: infrared, 13C and ¹H NMR, while the amount of quaternary ammonium groups was obtained by condutimetry. The removal of Cr (VI, Mo (VI and Se (VI from aqueous solutions was carried out in batch adsorption processes. The process seemed to be pH dependent for Cr (VI and Se (VI with an optimum pH ranging from 4.0 to 6.0; while for Mo (VI the adsorption remained almost constant within the range between 4.0 and 11.5. The Langmuir isotherm model provided the best fit of the equilibrium data over the whole concentration investigated. In the experiment

Self-assembled decanuclear Na(I)2Mn(II)4Mn(III)4 complexes: from discrete clusters to 1-D and 2-D structures, with the Mn(II)4Mn(III)4 unit displaying a large spin ground state and probable SMM behaviour.

Science.gov (United States)

Langley, Stuart K; Chilton, Nicholas F; Moubaraki, Boujemaa; Murray, Keith S

2011-12-07

The synthesis, magnetic characterization and X-ray crystal structures are reported for five new manganese compounds, [Mn(III)(teaH(2))(sal)]·(1/2)H(2)O (1), [Na(I)(2)Mn(II)(4)Mn(III)(4)(teaH)(6)(sal)(4)(N(3))(2)(MeOH)(4)]·6MeOH (2), [Na(I)(2)Mn(II)(4)Mn(III)(4)(teaH)(6)(sal)(4)(N(3))(2)(MeOH)(2)](n)·7MeOH (3), [Na(I)(2)Mn(II)(4)Mn(III)(4)(teaH)(6)(sal)(4)(N(3))(2)(MeOH)(2)](n)·2MeOH·Et(2)O (4) and [K(I)(2)Mn(II)(4)Mn(III)(4)(teaH)(6)(sal)(4)(N(3))(2)(H(2)O)(2)](n)·5MeOH (5). Complex 1 is a mononuclear compound, formed via the reaction of Mn(NO(3))(2)·4H(2)O, triethanolamine (teaH(3)) and salicylic acid (salH(2)) in a basic methanolic solution. Compound 2 is a mixed-valent hetero-metallic cluster made up of a Mn(8)Na(2) decanuclear core and is formed via the reaction of sodium azide (NaN(3)) with 1. Compounds 3-5 are isolated as 1- or 2-D coordination polymers, each containing the decanuclear Mn(8)M(2) (M = Na(+) or K(+)) core building block as the repeating unit. Compound 3 is isolated when 1 is reacted with NaN(3) over a very short reaction time and forms a 1-D coordination polymer. Each unit displays inter-cluster bridges via the O-atoms of teaH(2-) ligands bonding to the sodium ions of an adjacent cluster. Increasing the reaction time appears to drive the formation of 4 which forms 2-D polymeric sheets and is a packing polymorph of 3. The addition of KMnO(4) and NaN(3) to 1 resulted in compound 5, which also forms a 1-D coordination polymer of the decanuclear core unit. The 1-D chains are now linked via inter-cluster potassium and salicylate bridges. Solid state DC susceptibility measurements were performed on compounds 1-5. The data for 1 are as expected for an S = 2 Mn(III) ion, with the isothermal M vs. H data being fitted by matrix diagonalization methods to give values of g and the axial (D) and rhombic (E) zero field splitting parameters of 2.02, -2.70 cm(-1) and 0.36 cm(-1) respectively. The data for 2-5, each with an identical Mn(II)(4)Mn(III)(4

1,000 consecutive cases of laser-assisted liposuction and suction-assisted lipectomy managed with local anesthesia.

Science.gov (United States)

Chia, Christopher T; Theodorou, Spero J

2012-08-01

Advances in suction-assisted lipectomy (SAL) include improved instrumentation, better understanding of fluid dynamics, and an improved concept of appropriate indications. The tumescent technique uses subcutaneous injection of isotonic fluid containing vasoconstrictive and analgesic agents and is proved to be safe, with low morbidity and mortality rates. Laser-assisted liposuction (LAL) using local infiltration of an anesthetic and no general anesthesia or sedation has been developed, with claims of fat destruction and skin tightening. This study aimed to review 1,000 consecutive cases of LAL and SAL performed with the patient under local anesthesia and to determine whether this represents a safe technique with few complications. During a period of 22 months, 581 consecutive patients (486 females and 95 males) underwent 1,000 LAL/SAL operations, 545 of whom had multiple procedures performed. None of the patients had a body mass index (BMI) higher than 30 kg/m2. The patients ranged in age from 18 to 62 years. The fat aspirate ranged from 50 to 1,400 ml. Patients were given an oral sedative, an antibiotic, and an analgesic. Ringer's lactate solution containing lidocaine and epinephrine was injected into the subcutaneous space. The 1,064-nm and/or 1,320-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser was used for laser lipolysis followed by SAL using standard and/or power-assisted liposuction (PAL) cannulas. The treated areas included the neck, triceps, male breast, midback, flanks, axilla, abdomen, mons pubis, thighs, presacrum, and knees. No patient was administered intravenous sedation or general anesthesia. The average number of areas treated was 1.8, and no major complications or mortalities were observed. There were three burns, two infections, one hematoma, and one seroma. A total of 73 secondary procedures were performed (7.3%). No tertiary procedures were required. For appropriately selected patients, comparable results can be obtained with an excellent