A SOFTWARE TOOL FOR EXPERIMENTAL STUDY LEAP MOTION

OpenAIRE

Georgi Krastev; Magdalena Andreeva

2015-01-01

The paper aims to present computer application that illustrates Leap Motion controller’s abilities. It is a peripheral and software for PC, which enables control by natural user interface based on gestures. The publication also describes how the controller works and its main advantages/disadvantages. Some apps using leap motion controller are discussed.

LEAP 1992: Conference summary

International Nuclear Information System (INIS)

Dover, C.B.

1992-12-01

We present a summary of the many new results in antiproton (bar p) physics presented at the LEAP '92 conference, in the areas of meson spectroscopy, bar NN scattering, annihilation and spin observables, strangeness and charm production, bar N annihilation in nuclei, atomic physics with very low energy bar p's, the exploration of fundamental symmetries and interactions with bar p (CP, T, CPT, gravitation), and the prospects for new bar p facilities at ultralow energies or energies above the LEAR regime (≥ 2 GeV/c)

Energy Leap (Energiesprong). Long-term Plan. Update 2011

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-12-15

The Dutch government considers the transition process to be necessary and stimulates investments in energy innovations in the built environment. This innovation effort is the programme 'Energy Leap' (Energiesprong), which is being carried out by the Steering Group Experimental Housing (SEV) on behalf of the Dutch Ministry of the Interior and Kingdom Relations (BZK). The programme is derived from the Innovation Agenda for Energy in the Built Environment. The SEV 'Energy Leap' programme aims to make a substantial contribution to the conditions under which the energy transition can be achieved effectively. In this basic plan, it is explained how the market can arrive at this, and which activities will be supported, set up and/or implemented by Energy Leap.

Interim report on nodel evaluation methodology and the evaluation of LEAP

Energy Technology Data Exchange (ETDEWEB)

Alsmiller, R.G. Jr.; Barish, J.; Bjornstad, D.

1980-04-01

This report describes progress made at ORNL toward development and demonstration of a methodology for evaluating energy-economic modeling codes and important results derived from these codes. To bolster traditional evaluation methods with more-quantitative procedures of interest to the Energy Information Administration, ORNL is applying sensitivity theory as part of a comprehensive effort to quantify the importance of various data and model parameters to the key results that are of interest. The Long-Term Energy Analysis Program (LEAP) was chosen as the initial focus for the research. LEAP is an energy-economy model which resides in the Long-Term Energy Analysis Division (LTEAD) of the Integrative Analysis Group in the Office of Applied Analysis, EIA. LTEAD developed Model 22C of LEAP for two reasons: (1) to prepare projections through the year 2020, which were needed for the 1978 EIA Annual Report to Congress and (2) to develop a base for analyses of specific options for Federal action. LEAP Model 22C and its uses are described to provide the background for this interim description of the model evaluation effort at ORNL. 19 figures, 10 tables.

Leap frog in slow motion: Divergent responses of tree species and life stages to climatic warming in Great Basin subalpine forests.

Science.gov (United States)

Smithers, Brian V; North, Malcolm P; Millar, Constance I; Latimer, Andrew M

2018-02-01

In response to climate warming, subalpine treelines are expected to move up in elevation since treelines are generally controlled by growing season temperature. Where treeline is advancing, dispersal differences and early life stage environmental tolerances are likely to affect how species expand their ranges. Species with an establishment advantage will colonize newly available habitat first, potentially excluding species that have slower establishment rates. Using a network of plots across five mountain ranges, we described patterns of upslope elevational range shift for the two dominant Great Basin subalpine species, limber pine and Great Basin bristlecone pine. We found that the Great Basin treeline for these species is expanding upslope with a mean vertical elevation shift of 19.1 m since 1950, which is lower than what we might expect based on temperature increases alone. The largest advances were on limber pine-dominated granitic soils, on west aspects, and at lower latitudes. Bristlecone pine juveniles establishing above treeline share some environmental associations with bristlecone adults. Limber pine above-treeline juveniles, in contrast, are prevalent across environmental conditions and share few environmental associations with limber pine adults. Strikingly, limber pine is establishing above treeline throughout the region without regard to site characteristic such as soil type, slope, aspect, or soil texture. Although limber pine is often rare at treeline where it coexists with bristlecone pine, limber pine juveniles dominate above treeline even on calcareous soils that are core bristlecone pine habitat. Limber pine is successfully "leap-frogging" over bristlecone pine, probably because of its strong dispersal advantage and broader tolerances for establishment. This early-stage dominance indicates the potential for the species composition of treeline to change in response to climate change. More broadly, it shows how species differences in dispersal

Energy Leap (Energiesprong). Long-term Plan. Update 2011

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-12-15

The Dutch government considers the transition process to be necessary and stimulates investments in energy innovations in the built environment. This innovation effort is the programme 'Energy Leap' (Energiesprong), which is being carried out by the Steering Group Experimental Housing (SEV) on behalf of the Dutch Ministry of the Interior and Kingdom Relations (BZK). The programme is derived from the Innovation Agenda for Energy in the Built Environment. The SEV 'Energy Leap' programme aims to make a substantial contribution to the conditions under which the energy transition can be achieved effectively. In this basic plan, it is explained how the market can arrive at this, and which activities will be supported, set up and/or implemented by Energy Leap.

Hybrid chernoff tau-leap

KAUST Repository

Moraes, Alvaro

2014-01-01

Markovian pure jump processes model a wide range of phenomena, including chemical reactions at the molecular level, dynamics of wireless communication networks, and the spread of epidemic diseases in small populations. There exist algorithms such as Gillespie\\'s stochastic simulation algorithm (SSA) and Anderson\\'s modified next reaction method (MNRM) that simulate a single path with the exact distribution of the process, but this can be time consuming when many reactions take place during a short time interval. Gillespie\\'s approximated tau-leap method, on the other hand, can be used to reduce computational time, but it may lead to nonphysical values due to a positive one-step exit probability, and it also introduces a time discretization error. Here, we present a novel hybrid algorithm for simulating individual paths which adaptively switches between the SSA and the tau-leap method. The switching strategy is based on a comparison of the expected interarrival time of the SSA and an adaptive time step derived from a Chernoff-type bound for the one-step exit probability. Because this bound is nonasymptotic, we do not need to make any distributional approximation for the tau-leap increments. This hybrid method allows us (i) to control the global exit probability of any simulated path and (ii) to obtain accurate and computable estimates of the expected value of any smooth observable of the process with minimal computational work. We present numerical examples that illustrate the performance of the proposed method. © 2014 Society for Industrial and Applied Mathematics.

The laboratory environmental algae pond simulator (LEAPS) photobioreactor: Validation using outdoor pond cultures of Chlorella sorokiniana and Nannochloropsis salina

Energy Technology Data Exchange (ETDEWEB)

Huesemann, M.; Williams, P.; Edmundson, S.; Chen, P.; Kruk, R.; Cullinan, V.; Crowe, B.; Lundquist, T.

2017-09-01

A bench-scale photobioreactor system, termed Laboratory Environmental Algae Pond Simulator (LEAPS), was designed and constructed to simulate outdoor pond cultivation for a wide range of geographical locations and seasons. The LEAPS consists of six well-mixed glass column photobioreactors sparged with CO2-enriched air to maintain a set-point pH, illuminated from above by a programmable multicolor LED lighting (0 to 2,500 µmol/m2-sec), and submerged in a temperature controlled water-bath (-2 °C to >60 °C). Measured incident light intensities and water temperatures deviated from the respective light and temperature set-points on average only 2.3% and 0.9%, demonstrating accurate simulation of light and temperature conditions measured in outdoor ponds. In order to determine whether microalgae strains cultured in the LEAPS exhibit the same linear phase biomass productivity as in outdoor ponds, Chlorella sorokiniana and Nannochloropsis salina were cultured in the LEAPS bioreactors using light and temperature scripts measured previously in the respective outdoor pond studies. For Chlorella sorokiniana, the summer season biomass productivity in the LEAPS was 6.6% and 11.3% lower than in the respective outdoor ponds in Rimrock, Arizona, and Delhi, California; however, these differences were not statistically significant. For Nannochloropsis salina, the winter season biomass productivity in the LEAPS was statistically significantly higher (15.2%) during the 27 day experimental period than in the respective outdoor ponds in Tucson, Arizona. However, when considering only the first 14 days, the LEAPS biomass productivity was only 9.2% higher than in the outdoor ponds, a difference shown to be not statistically significant. Potential reasons for the positive or negative divergence in LEAPS performance, relative to outdoor ponds, are discussed. To demonstrate the utility of the LEAPS in predicting productivity, two other strains – Scenedesmus obliquus and Stichococcus minor

Leap Motion controller application in augmented reality technology

OpenAIRE

Artemčiukas, Edgaras; Sakalauskas, Leonidas

2014-01-01

In this work the analysis of interaction techniques, devices and its’ possibilities were accomplished. It was determined that the problem, which many researchers tries to solve – more natural interaction between users and computers. Interaction system in augmented reality environment using Leap Motion controller was developed. To achieve this goal augmented reality NyARToolkit and Leap Motion controller libraries were used. Solution ensures extensive information about hand, finger...

Evaluation of the leap motion controller as a new contact-free pointing device.

Science.gov (United States)

Bachmann, Daniel; Weichert, Frank; Rinkenauer, Gerhard

2014-12-24

This paper presents a Fitts' law-based analysis of the user's performance in selection tasks with the Leap Motion Controller compared with a standard mouse device. The Leap Motion Controller (LMC) is a new contact-free input system for gesture-based human-computer interaction with declared sub-millimeter accuracy. Up to this point, there has hardly been any systematic evaluation of this new system available. With an error rate of 7.8% for the LMC and 2.8% for the mouse device, movement times twice as large as for a mouse device and high overall effort ratings, the Leap Motion Controller's performance as an input device for everyday generic computer pointing tasks is rather limited, at least with regard to the selection recognition provided by the LMC.

Pengenalan Isyarat Tangan Menggunakan Leap Motion Controller untuk Pertunjukan Boneka Tangan Virtual

OpenAIRE

Dzulkarnain, Iskandar; Sumpeno, Surya; Christyowidiasmoro, Christyowidiasmoro

2016-01-01

Leap Motion Controller memiliki keterbatasan dalam menangkap gerak isyarat tangan. Keterbatasan tersebut menyebabkan gerakan tangan model boneka virtual tidak seakurat gerakan tangan pelakon. Selain itu, konfigurasi bone model dimensi tiga untuk Leap Motion Controller berbeda dengan konfigurasi bone dimensi tiga pada umumnya. Oleh karena itu, dilakukan pengenalan isyarat tangan menggunakan Leap Motion Controller untuk pertunjukan boneka tangan virtual. Pengenalan isyarat tangan tersebut dilak...

Pengenalan Isyarat Tangan Menggunakan Leap Motion Controller untuk Pertunjukan Boneka Tangan Virtual

Directory of Open Access Journals (Sweden)

Iskandar Dzulkarnain

2017-01-01

Full Text Available Leap Motion Controller memiliki keterbatasan dalam menangkap gerak isyarat tangan. Keterbatasan tersebut menyebabkan gerakan tangan model boneka virtual tidak seakurat gerakan tangan pelakon. Selain itu, konfigurasi bone model dimensi tiga untuk Leap Motion Controller berbeda dengan konfigurasi bone dimensi tiga pada umumnya. Oleh karena itu, dilakukan pengenalan isyarat tangan menggunakan Leap Motion Controller untuk pertunjukan boneka tangan virtual. Pengenalan isyarat tangan tersebut dilakukan dengan memetakan hasil penjejakan tangan dari Leap Motion Controller ke dalam model prefab tangan Leap SDK. Setelah berhasil dipetakan, konfigurasi bone dari model prefab tangan Leap SDK diadaptasi ke dalam model boneka tangan virtual. Adaptasi tersebut dilakukan dengan mengatur posisi dan orientasi bone pada model dimensi tiga boneka tangan. Setelah posisi dan orientasi bone yang sesuai ditemukan, model dimensi tiga boneka tangan diuji menirukan gerakan boneka tangan asli. Pengujian boneka tangan virtual pada sembarang orang dilakukan untuk mengetahui tingkat kesinkronan gerak mulut atas dan mulut bawah boneka tangan virtual. Dari pengujian sembarang orang, didapatkan hasil 50% setuju dan 5,6% sangat setuju gerak mulut atas sinkron dengan gerak tangan. Sedangkan untuk gerak mulut bawah sinkron dengan gerak tangan didapatkan 16,7% setuju dan 11,1% sangat setuju.

LEAP Phase II, Net Energy Gain From Laser Fields in Vacuum

International Nuclear Information System (INIS)

Barnes, C.D.; Colby, E.R.; Plettner, T.

2005-01-01

The current Laser Electron Acceleration Program (LEAP) seeks to modulate the energy of an electron bunch by interaction of the electrons with a copropagating pair of crossed laser beams at 800 nm. We present an optical injector design for a LEAP cell so that it can be used to give net energy gain to an electron bunch. Unique features of the design are discussed which will allow this net energy gain and which will also provide a robust signature for the LEAP interaction

LEAP Phase II, net energy gain from laser fields in vacuum

International Nuclear Information System (INIS)

Barnes, Christopher D.; Colby, Eric R.; Plettner, Tomas

2002-01-01

The current Laser Electron Acceleration Program (LEAP) seeks to modulate the energy of an electron bunch by interaction of the electrons with a copropagating pair of crossed laser beams at 800 nm. We present an optical injector design for a LEAP cell so that it can be used to give net energy gain to an electron bunch. Unique features of the design are discussed which will allow this net energy gain and which will also provide a robust signature for the LEAP interaction

Evaluation of the Leap Motion Controller as a New Contact-Free Pointing Device

Directory of Open Access Journals (Sweden)

Daniel Bachmann

2014-12-01

Full Text Available This paper presents a Fitts’ law-based analysis of the user’s performance in selection tasks with the Leap Motion Controller compared with a standard mouse device. The Leap Motion Controller (LMC is a new contact-free input system for gesture-based human-computer interaction with declared sub-millimeter accuracy. Up to this point, there has hardly been any systematic evaluation of this new system available. With an error rate of 7.8% for the LMC and 2.8% for the mouse device, movement times twice as large as for a mouse device and high overall effort ratings, the Leap Motion Controller’s performance as an input device for everyday generic computer pointing tasks is rather limited, at least with regard to the selection recognition provided by the LMC.

LEAP [Low-Energy Antiproton]: A balloon-borne search for low-energy cosmic-ray antiprotons

International Nuclear Information System (INIS)

Moats, A.R.M.

1989-01-01

The LEAP (Low-Energy Antiproton) experiment is a search for cosmic-ray antiprotons in the 120 MeV to 1.2 GeV kinetic energy range. The motivation for this project was the result announced by Buffington et. al. (1981) that indicated an anomalously high antiproton flux below 300 MeV; this result has compelled theorists to propose sources of primary antiprotons above the small secondary antiproton flux produced by high energy cosmic-ray collisions with nuclei in the interstellar medium. LEAP consisted of the NMSU magnetic spectrometer, a time-of-flight system designed at Goddard Space Flight Center, two scintillation detectors, and a Cherenkov counter designed and built at the University of Arizona. Analysis of flight data performed by the high-energy astrophysics group at Goddard Space Flight Center revealed no antiproton candidates found in the 120 MeV to 360 MeV range; 3 possible antiproton candidate events were found in the 500 MeV to 1.2 GeV range in an analysis done here at the University of Arizona. However, since it will be necessary to sharpen the calibration on all of the LEAP systems in order to positively identify these events as antiprotons, only an upper limit has been determined at present. Thus, combining the analyses performed at the University of Arizona and Goddard Space Flight Center, 90% confidence upper limits of 3.5 x 10 -5 in the 120 MeV to 360 MeV range and 2.3 x 10 -4 in the 500 MeV to 1.2 GeV range for the antiproton/proton ratio is indicated by the LEAP results. LEAP disagrees sharply with the results of the Buffington group, indicating a low antiproton flux at these energies

Mechanical characterization of densely welded Apache Leap tuff

International Nuclear Information System (INIS)

Fuenkajorn, K.; Daemen, J.J.K.

1991-06-01

An empirical criterion is formulated to describe the compressive strength of the densely welded Apache Leap tuff. The criterion incorporates the effects of size, L/D ratio, loading rate and density variations. The criterion improves the correlation between the test results and the failure envelope. Uniaxial and triaxial compressive strengths, Brazilian tensile strength and elastic properties of the densely welded brown unit of the Apache Leap tuff have been determined using the ASTM standard test methods. All tuff samples are tested dry at room temperature (22 ± 2 degrees C), and have the core axis normal to the flow layers. The uniaxial compressive strength is 73.2 ± 16.5 MPa. The Brazilian tensile strength is 5.12 ± 1.2 MPa. The Young's modulus and Poisson's ratio are 22.6 ± 5.7 GPa and 0.20 ± 0.03. Smoothness and perpendicularity do not fully meet the ASTM requirements for all samples, due to the presence of voids and inclusions on the sample surfaces and the sample preparation methods. The investigations of loading rate, L/D radio and cyclic loading effects on the compressive strength and of the size effect on the tensile strength are not conclusive. The Coulomb strength criterion adequately represents the failure envelope of the tuff under confining pressures from 0 to 62 MPa. Cohesion and internal friction angle are 16 MPa and 43 degrees. The brown unit of the Apache Leap tuff is highly heterogeneous as suggested by large variations of the test results. The high intrinsic variability of the tuff is probably caused by the presence of flow layers and by nonuniform distributions of inclusions, voids and degree of welding. Similar variability of the properties has been found in publications on the Topopah Spring tuff at Yucca Mountain. 57 refs., 32 figs., 29 tabs

The Power of Cooperation in International Paleoclimate Science: Examples from the PAGES 2k Network and the Ocean2k Working Group

Science.gov (United States)

Addison, J. A.

2015-12-01

The Past Global Changes (PAGES) project of IGBP and Future Earth supports research to understand the Earth's past environment to improve future climate predictions and inform strategies for sustainability. Within this framework, the PAGES 2k Network was established to provide a focus on the past 2000 years, a period that encompasses Medieval Climate Anomaly warming, Little Ice Age cooling, and recent anthropogenically-forced climate change. The results of these studies are used for testing earth system models, and for understanding decadal- to centennial-scale variability, which is needed for long-term planning. International coordination and cooperation among the nine regional Working Groups that make up the 2k Network has been critical to the success of PAGES 2k. The collaborative approach is moving toward scientific achievements across the regional groups, including: (i) the development of a community-driven open-access proxy climate database; (ii) integration of multi-resolution proxy records; (iii) development of multivariate climate reconstructions; and (iv) a leap forward in the spatial resolution of paleoclimate reconstructions. The last addition to the 2k Network, the Ocean2k Working Group has further innovated the collaborative approach by: (1) creating an open, receptive environment to discuss ideas exclusively in the virtual space; (2) employing an array of real-time collaborative software tools to enable communication, group document writing, and data analysis; (3) consolidating executive leadership teams to oversee project development and manage grassroots-style volunteer pools; and (4) embracing the value-added role that international and interdisciplinary science can play in advancing paleoclimate hypotheses critical to understanding future change. Ongoing efforts for the PAGES 2k Network are focused on developing new standards for data quality control and archiving. These tasks will provide the foundation for new and continuing "trans-regional" 2k

LEAP: biomarker inference through learning and evaluating association patterns.

Science.gov (United States)

Jiang, Xia; Neapolitan, Richard E

2015-03-01

Single nucleotide polymorphism (SNP) high-dimensional datasets are available from Genome Wide Association Studies (GWAS). Such data provide researchers opportunities to investigate the complex genetic basis of diseases. Much of genetic risk might be due to undiscovered epistatic interactions, which are interactions in which combination of several genes affect disease. Research aimed at discovering interacting SNPs from GWAS datasets proceeded in two directions. First, tools were developed to evaluate candidate interactions. Second, algorithms were developed to search over the space of candidate interactions. Another problem when learning interacting SNPs, which has not received much attention, is evaluating how likely it is that the learned SNPs are associated with the disease. A complete system should provide this information as well. We develop such a system. Our system, called LEAP, includes a new heuristic search algorithm for learning interacting SNPs, and a Bayesian network based algorithm for computing the probability of their association. We evaluated the performance of LEAP using 100 1,000-SNP simulated datasets, each of which contains 15 SNPs involved in interactions. When learning interacting SNPs from these datasets, LEAP outperformed seven others methods. Furthermore, only SNPs involved in interactions were found to be probable. We also used LEAP to analyze real Alzheimer's disease and breast cancer GWAS datasets. We obtained interesting and new results from the Alzheimer's dataset, but limited results from the breast cancer dataset. We conclude that our results support that LEAP is a useful tool for extracting candidate interacting SNPs from high-dimensional datasets and determining their probability. © 2015 The Authors. *Genetic Epidemiology published by Wiley Periodicals, Inc.

Evaluation of the Leap Motion Controller as a New Contact-Free Pointing Device

OpenAIRE

Bachmann, Daniel; Weichert, Frank; Rinkenauer, Gerhard

2014-01-01

This paper presents a Fitts' law-based analysis of the user's performance in selection tasks with the Leap Motion Controller compared with a standard mouse device. The Leap Motion Controller (LMC) is a new contact-free input system for gesture-based human-computer interaction with declared sub-millimeter accuracy. Up to this point, there has hardly been any systematic evaluation of this new system available. With an error rate of 7.8 % for the LMC and 2.8% for the mouse device, movement times...

K2P2- A photometry pipeline for the K2 mission

DEFF Research Database (Denmark)

Lund, Mikkel N.; Handberg, Rasmus; Davies, Guy R.

2015-01-01

With the loss of a second reaction wheel, resulting in the inability to point continuously and stably at the same field of view, the NASA Kepler satellite recently entered a new mode of observation known as the K2 mission. The data from this redesigned mission present a specific challenge......; the targets systematically drift in position on a ~6 hour time scale, inducing a significant instrumental signal in the photometric time series --- this greatly impacts the ability to detect planetary signals and perform asteroseismic analysis. Here we detail our version of a reduction pipeline for K2 target...... the KASOC filter (Handberg & Lund 2014), thus rendering the time series ready for asteroseismic analysis; computes power spectra for all targets, and identifies potential contaminations between targets. From a test of our pipeline on a sample of targets from the K2 campaign 0, the recovery of data...

A syncopated leap-frog algorithm for orbit consistent plasma simulation of materials processing reactors

International Nuclear Information System (INIS)

Cobb, J.W.; Leboeuf, J.N.

1994-01-01

The authors present a particle algorithm to extend simulation capabilities for plasma based materials processing reactors. The orbit integrator uses a syncopated leap-frog algorithm in cylindrical coordinates, which maintains second order accuracy, and minimizes computational complexity. Plasma source terms are accumulated orbit consistently directly in the frequency and azimuthal mode domains. Finally they discuss the numerical analysis of this algorithm. Orbit consistency greatly reduces the computational cost for a given level of precision. The computational cost is independent of the degree of time scale separation

Y2K embedded device issues in the oilpatch

International Nuclear Information System (INIS)

Lovatt, M.

1998-01-01

Information on the background of the year 2000 (Y2K) problem in process control systems in the oil and gas industry was presented. The problem, which stems from a date related malfunction, could result in a series of computer failures. Examples of the type of failures that process control devices at an electricity generating plant may experience as a result of the date change to the year 2000 ( rollover, leap year, special codes) were illustrated. The benefits of a shared process across the industry for testing and evaluating the potential for failure were stressed. As a general methodology for solving Y2K problems, an inventory should be taken to identify all items that may have date related aspects and to plan a strategy for remediation. The 'JumpStart' database has been developed as a tool for sharing information and to help businesses to move quickly through the assessment strategy phase of their Y2K projects. At present, this database contains over 41,000 separate items from over 5000 manufacturers. Since the beginning of collecting data for this database only 10 to 15 per cent of the devices showed any type of date-related failure, and only one to five per cent of these was a critical failure. Several examples of how devices fail are provided. 1 fig

Avoiding negative populations in explicit Poisson tau-leaping.

Science.gov (United States)

Cao, Yang; Gillespie, Daniel T; Petzold, Linda R

2005-08-01

The explicit tau-leaping procedure attempts to speed up the stochastic simulation of a chemically reacting system by approximating the number of firings of each reaction channel during a chosen time increment tau as a Poisson random variable. Since the Poisson random variable can have arbitrarily large sample values, there is always the possibility that this procedure will cause one or more reaction channels to fire so many times during tau that the population of some reactant species will be driven negative. Two recent papers have shown how that unacceptable occurrence can be avoided by replacing the Poisson random variables with binomial random variables, whose values are naturally bounded. This paper describes a modified Poisson tau-leaping procedure that also avoids negative populations, but is easier to implement than the binomial procedure. The new Poisson procedure also introduces a second control parameter, whose value essentially dials the procedure from the original Poisson tau-leaping at one extreme to the exact stochastic simulation algorithm at the other; therefore, the modified Poisson procedure will generally be more accurate than the original Poisson procedure.

Evaluering av Leap Motion kontrollern för visualisering av musik

OpenAIRE

Uvman, Oliver

2016-01-01

An experiment was carried out, attempting to ascertain whether the Leap Motion Controller can be a useful input device for dynamically controlling graphic visualizations, e.g. by artists who use video and interactive visual arts to enhance music performances. The Leap Motion Controller was found to be too unreliable to be used as the primary controller in a professional visual arts performance.

3D hra s technologií Leap Motion

OpenAIRE

Mainuš, Matěj

2014-01-01

Cílem této bakalářské práce bylo navrhnout a implementovat 3D hru labyrint ovládanou pomocí gest rukou. Pro rozpoznávání pohybu a gest hra využívá technologii Leap Motion, aplikace samotná je vytvořena v herním enginu Unity. Výsledkem práce je multiplatformní 3D hra s vlastní knihovnou, která integruje Leap Motion SDK do Unity a eliminuje chyby v detekci rukou. The goal of this bachelor's thesis is to design and create a 3D labyrinth game controlled by hand gestures. This is achieved by us...

SparseLeap: Efficient Empty Space Skipping for Large-Scale Volume Rendering

KAUST Repository

Hadwiger, Markus; Al-Awami, Ali K.; Beyer, Johanna; Agus, Marco; Pfister, Hanspeter

2017-01-01

Recent advances in data acquisition produce volume data of very high resolution and large size, such as terabyte-sized microscopy volumes. These data often contain many fine and intricate structures, which pose huge challenges for volume rendering, and make it particularly important to efficiently skip empty space. This paper addresses two major challenges: (1) The complexity of large volumes containing fine structures often leads to highly fragmented space subdivisions that make empty regions hard to skip efficiently. (2) The classification of space into empty and non-empty regions changes frequently, because the user or the evaluation of an interactive query activate a different set of objects, which makes it unfeasible to pre-compute a well-adapted space subdivision. We describe the novel SparseLeap method for efficient empty space skipping in very large volumes, even around fine structures. The main performance characteristic of SparseLeap is that it moves the major cost of empty space skipping out of the ray-casting stage. We achieve this via a hybrid strategy that balances the computational load between determining empty ray segments in a rasterization (object-order) stage, and sampling non-empty volume data in the ray-casting (image-order) stage. Before ray-casting, we exploit the fast hardware rasterization of GPUs to create a ray segment list for each pixel, which identifies non-empty regions along the ray. The ray-casting stage then leaps over empty space without hierarchy traversal. Ray segment lists are created by rasterizing a set of fine-grained, view-independent bounding boxes. Frame coherence is exploited by re-using the same bounding boxes unless the set of active objects changes. We show that SparseLeap scales better to large, sparse data than standard octree empty space skipping.

SparseLeap: Efficient Empty Space Skipping for Large-Scale Volume Rendering

KAUST Repository

Hadwiger, Markus

2017-08-28

Recent advances in data acquisition produce volume data of very high resolution and large size, such as terabyte-sized microscopy volumes. These data often contain many fine and intricate structures, which pose huge challenges for volume rendering, and make it particularly important to efficiently skip empty space. This paper addresses two major challenges: (1) The complexity of large volumes containing fine structures often leads to highly fragmented space subdivisions that make empty regions hard to skip efficiently. (2) The classification of space into empty and non-empty regions changes frequently, because the user or the evaluation of an interactive query activate a different set of objects, which makes it unfeasible to pre-compute a well-adapted space subdivision. We describe the novel SparseLeap method for efficient empty space skipping in very large volumes, even around fine structures. The main performance characteristic of SparseLeap is that it moves the major cost of empty space skipping out of the ray-casting stage. We achieve this via a hybrid strategy that balances the computational load between determining empty ray segments in a rasterization (object-order) stage, and sampling non-empty volume data in the ray-casting (image-order) stage. Before ray-casting, we exploit the fast hardware rasterization of GPUs to create a ray segment list for each pixel, which identifies non-empty regions along the ray. The ray-casting stage then leaps over empty space without hierarchy traversal. Ray segment lists are created by rasterizing a set of fine-grained, view-independent bounding boxes. Frame coherence is exploited by re-using the same bounding boxes unless the set of active objects changes. We show that SparseLeap scales better to large, sparse data than standard octree empty space skipping.

Improvement of blow down model for LEAP code

International Nuclear Information System (INIS)

Itooka, Satoshi; Fujimata, Kazuhiro

2003-03-01

In Japan Nuclear Cycle Development Institute, the improvement of analysis method for overheating tube rapture was studied for the accident of sodium-water reactions in the steam generator of a fast breeder reactor and the evaluation of heat transfer condition in the tube were carried out based on study of critical heat flux (CHF) and post-CHF heat transfer equation in Light Water Reactors. In this study, the improvement of blow down model for the LEAP code was carried out taking into consideration the above-mentioned evaluation of heat transfer condition. Improvements of the LEAP code were following items. Calculations and verification were performed with the improved LEAP code in order to confirm the code functions. The addition of critical heat flux (CHF) by the formula of Katto and the formula of Tong. The addition of post-CHF heat transfer equation by the formula of Condie-BengstonIV and the formula of Groeneveld 5.9. The physical properties of the water and steam are expanded to the critical conditions of the water. The expansion of the total number of section and the improvement of the input form. The addition of the function to control the valve setting by the PID control model. (author)

Drift-Implicit Multi-Level Monte Carlo Tau-Leap Methods for Stochastic Reaction Networks

KAUST Repository

Ben Hammouda, Chiheb

2015-05-12

In biochemical systems, stochastic e↵ects can be caused by the presence of small numbers of certain reactant molecules. In this setting, discrete state-space and stochastic simulation approaches were proved to be more relevant than continuous state-space and deterministic ones. These stochastic models constitute the theory of stochastic reaction networks (SRNs). Furthermore, in some cases, the dynamics of fast and slow time scales can be well separated and this is characterized by what is called sti↵ness. For such problems, the existing discrete space-state stochastic path simulation methods, such as the stochastic simulation algorithm (SSA) and the explicit tau-leap method, can be very slow. Therefore, implicit tau-leap approxima- tions were developed to improve the numerical stability and provide more e cient simulation algorithms for these systems. One of the interesting tasks for SRNs is to approximate the expected values of some observables of the process at a certain fixed time T. This is can be achieved using Monte Carlo (MC) techniques. However, in a recent work, Anderson and Higham in 2013, proposed a more computationally e cient method which combines multi-level Monte Carlo (MLMC) technique with explicit tau-leap schemes. In this MSc thesis, we propose new fast stochastic algorithm, particularly designed 5 to address sti↵ systems, for approximating the expected values of some observables of SRNs. In fact, we take advantage of the idea of MLMC techniques and drift-implicit tau-leap approximation to construct a drift-implicit MLMC tau-leap estimator. In addition to accurately estimating the expected values of a given observable of SRNs at a final time T , our proposed estimator ensures the numerical stability with a lower cost than the MLMC explicit tau-leap algorithm, for systems including simultane- ously fast and slow species. The key contribution of our work is the coupling of two drift-implicit tau-leap paths, which is the basic brick for

Evaluation of a portable markerless finger position capture device: accuracy of the Leap Motion controller in healthy adults.

Science.gov (United States)

Tung, James Y; Lulic, Tea; Gonzalez, Dave A; Tran, Johnathan; Dickerson, Clark R; Roy, Eric A

2015-05-01

Although motion analysis is frequently employed in upper limb motor assessment (e.g. visually-guided reaching), they are resource-intensive and limited to laboratory settings. This study evaluated the reliability and accuracy of a new markerless motion capture device, the Leap Motion controller, to measure finger position. Testing conditions that influence reliability and agreement between the Leap and a research-grade motion capture system were examined. Nine healthy young adults pointed to 15 targets on a computer screen under two conditions: (1) touching the target (touch) and (2) 4 cm away from the target (no-touch). Leap data was compared to an Optotrak marker attached to the index finger. Across all trials, root mean square (RMS) error of the Leap system was 17.30  ±  9.56 mm (mean ± SD), sampled at 65.47  ±  21.53 Hz. The % viable trials and mean sampling rate were significantly lower in the touch condition (44% versus 64%, p motion capture systems, the Leap Motion controller is sufficiently reliable for measuring motor performance in pointing tasks that do not require high positional accuracy (e.g. reaction time, Fitt's, trails, bimanual coordination).

Analysis of the Accuracy and Robustness of the Leap Motion Controller

OpenAIRE

Weichert, Frank; Bachmann, Daniel; Rudak, Bartholomäus; Fisseler, Denis

2013-01-01

The Leap Motion Controller is a new device for hand gesture controlled user interfaces with declared sub-millimeter accuracy. However, up to this point its capabilities in real environments have not been analyzed. Therefore, this paper presents a first study of a Leap Motion Controller. The main focus of attention is on the evaluation of the accuracy and repeatability. For an appropriate evaluation, a novel experimental setup was developed making use of an industrial robot with a reference pe...

Initial Experiments with the Leap Motion as a User Interface in Robotic Endonasal Surgery.

Science.gov (United States)

Travaglini, T A; Swaney, P J; Weaver, Kyle D; Webster, R J

The Leap Motion controller is a low-cost, optically-based hand tracking system that has recently been introduced on the consumer market. Prior studies have investigated its precision and accuracy, toward evaluating its usefulness as a surgical robot master interface. Yet due to the diversity of potential slave robots and surgical procedures, as well as the dynamic nature of surgery, it is challenging to make general conclusions from published accuracy and precision data. Thus, our goal in this paper is to explore the use of the Leap in the specific scenario of endonasal pituitary surgery. We use it to control a concentric tube continuum robot in a phantom study, and compare user performance using the Leap to previously published results using the Phantom Omni. We find that the users were able to achieve nearly identical average resection percentage and overall surgical duration with the Leap.

Initial Experiments with the Leap Motion as a User Interface in Robotic Endonasal Surgery

Science.gov (United States)

Travaglini, T. A.; Swaney, P. J.; Weaver, Kyle D.; Webster, R. J.

2016-01-01

The Leap Motion controller is a low-cost, optically-based hand tracking system that has recently been introduced on the consumer market. Prior studies have investigated its precision and accuracy, toward evaluating its usefulness as a surgical robot master interface. Yet due to the diversity of potential slave robots and surgical procedures, as well as the dynamic nature of surgery, it is challenging to make general conclusions from published accuracy and precision data. Thus, our goal in this paper is to explore the use of the Leap in the specific scenario of endonasal pituitary surgery. We use it to control a concentric tube continuum robot in a phantom study, and compare user performance using the Leap to previously published results using the Phantom Omni. We find that the users were able to achieve nearly identical average resection percentage and overall surgical duration with the Leap. PMID:26752501

Leaping Shampoo and the Stable Kaye Effect

NARCIS (Netherlands)

Versluis, Michel; Blom, C.; van der Meer, Roger M.; van der Weele, J.P.; Lohse, Detlef

2006-01-01

The 'Leaping Shampoo' video reveals the underlying physical mechanisms of the so-called Kaye effect. The spectacular effect is a classic textbook example to illustrate the rich dynamics of complex fluids and was first described by A. Kaye in a 1963 Nature paper, however, no published discussion or

Environmental and economic assessment of landfill gas electricity generation in Korea using LEAP model

International Nuclear Information System (INIS)

Shin, Ho-Chul; Park, Jin-Won; Kim, Ho-Seok; Shin, Eui-Soon

2005-01-01

As a measure to establish a climate-friendly energy system, Korean government has proposed to expand landfill gas (LFG) electricity generation capacity. The purpose of this paper is to analyze the impacts of LFG electricity generation on the energy market, the cost of generating electricity and greenhouse gases emissions in Korea using a computer-based software tool called 'Long-range Energy Alternative Planning system' (LEAP) and the associated 'Technology and Environmental Database'. In order to compare LFG electricity generation with existing other generating facilities, business as usual scenario of existing power plants was surveyed, and then alternative scenario investigations were performed using LEAP model. Different alternative scenarios were considered, namely the base case with existing electricity facilities, technological improvement of gas engine and LFG maximum utilization potential with different options of gas engine (GE), gas turbine (GT), and steam turbine (ST). In the technological improvement scenario, there will be 2.86 GWh or more increase in electricity output, decrease of 45 million won (Exchange rate (1$=1200 won)). in costs, and increase of 10.3 thousand ton of CO 2 in global warming potentials due to same period (5 year) of technological improvement. In the maximum utilization potential scenario, LFG electricity generation technology is substituted for coal steam, nuclear, and combined cycle process. Annual cost per electricity product of LFG electricity facilities (GE 58MW, GT 53.5MW, and ST 54.5MW) are 45.1, 34.3, and 24.4 won/kWh, and steam turbine process is cost-saving. LFG-utilization with other forms of energy utilization reduces global warming potential by maximum 75% with compared to spontaneous emission of CH 4 . LFG electricity generation would be the good solution for CO 2 displacement over the medium term and additional energy profits

Multilevel hybrid split-step implicit tau-leap

KAUST Repository

Ben Hammouda, Chiheb

2016-06-17

In biochemically reactive systems with small copy numbers of one or more reactant molecules, the dynamics is dominated by stochastic effects. To approximate those systems, discrete state-space and stochastic simulation approaches have been shown to be more relevant than continuous state-space and deterministic ones. In systems characterized by having simultaneously fast and slow timescales, existing discrete space-state stochastic path simulation methods, such as the stochastic simulation algorithm (SSA) and the explicit tau-leap (explicit-TL) method, can be very slow. Implicit approximations have been developed to improve numerical stability and provide efficient simulation algorithms for those systems. Here, we propose an efficient Multilevel Monte Carlo (MLMC) method in the spirit of the work by Anderson and Higham (SIAM Multiscal Model. Simul. 10(1), 2012). This method uses split-step implicit tau-leap (SSI-TL) at levels where the explicit-TL method is not applicable due to numerical stability issues. We present numerical examples that illustrate the performance of the proposed method. © 2016 Springer Science+Business Media New York

Energy efficiency and CO_2 mitigation potential of the Turkish iron and steel industry using the LEAP (long-range energy alternatives planning) system

International Nuclear Information System (INIS)

Ates, Seyithan A.

2015-01-01

With the assistance of the LEAP (long-range energy alternatives planning) energy modeling tool, this study explores the energy efficiency and CO_2 emission reduction potential of the iron and steel industry in Turkey. With a share of 35%, the steel and iron industry is considered as the most energy-consuming sector in Turkey. The study explores that the energy intensity rate can be lowered by 13%, 38% and 51% in SEI (slow-speed energy efficiency improvement), AEI (accelerating energy efficiency improvement) and CPT (cleaner production and technology scenario) scenarios, respectively. Particularly the projected aggregated energy savings of the scenarios CPT and AES are very promising with saving rates of 33.7% and 23% respectively. Compared to baseline scenarios, energy efficiency improvements correspond to economic potential of 0.1 billion dollars for SEI, 1.25 dollars for AEI and 1.8 billion dollars for CPT scenarios annually. Concerning GHG (greenhouse gas) emissions, in 2030 the iron and steel industry in Turkey is estimated to produce 34.9 MtCO_2 in BAU (business-as-usual scenario), 32.5 MtCO_2 in SEI, 24.6 MtCO_2 in AEI and 14.5 MtCO_2 in CPT a scenario which corresponds to savings of 9%–39%. The study reveals that energy consumption and GHG emissions of the iron and steel industry can be lowered significantly if the necessary measures are implemented. It is expected that this study will fill knowledge gaps pertaining to energy efficiency potential in Turkish energy intensive industries and help stakeholders in energy intensive industries to realize the potential for energy efficiency and GHG mitigation. - Highlights: • This paper explores energy efficiency potential of iron and Steel industry in Turkey. • We applied the LEAP modeling to forecast future developments. • Four different scenarios have been developed for the LEAP modeling. • There is a huge potential for energy efficiency and mitigation of GHG emissions.

Model for neural signaling leap statistics

International Nuclear Information System (INIS)

Chevrollier, Martine; Oria, Marcos

2011-01-01

We present a simple model for neural signaling leaps in the brain considering only the thermodynamic (Nernst) potential in neuron cells and brain temperature. We numerically simulated connections between arbitrarily localized neurons and analyzed the frequency distribution of the distances reached. We observed qualitative change between Normal statistics (with T 37.5 0 C, awaken regime) and Levy statistics (T = 35.5 0 C, sleeping period), characterized by rare events of long range connections.

Model for neural signaling leap statistics

Science.gov (United States)

Chevrollier, Martine; Oriá, Marcos

2011-03-01

We present a simple model for neural signaling leaps in the brain considering only the thermodynamic (Nernst) potential in neuron cells and brain temperature. We numerically simulated connections between arbitrarily localized neurons and analyzed the frequency distribution of the distances reached. We observed qualitative change between Normal statistics (with T = 37.5°C, awaken regime) and Lévy statistics (T = 35.5°C, sleeping period), characterized by rare events of long range connections.

The capabilities and constraints of the LEAP (Long-range Energy Alternatives Planning System) for development of energy matrix; As potencialidades e restricoes do LEAP (Long-range Energy Alternatives Planning System) para o desenvolvimento de matriz energetica

Energy Technology Data Exchange (ETDEWEB)

Santos, Afonso Henriques Moreira [MS Consultoria Ltda, Itajuba, MG (Brazil); Universidade Federal de Itajuba (UNIFEI), MG (Brazil); Cruz, Ricardo Alexandre Passos da; Magalhaes, Ricardo Nogueira [IX Consultoria e Representacoes Ltda, Itajuba, MG (Brazil)

2010-07-01

This paper seeks to introduce and discuss the main features of the LEAP model preparing energy matrixes, in the medium and long term energy planning context. These characteristics are analyzed and compared to other known simulation models used worldwide, checking potentialities and existing barriers of using the LEAP program (author)

Low Emissions Alternative Power (LEAP) Project Office Business Team of the Aeropropulsion Research Program Office (ARPO) Org. 0140

Science.gov (United States)

Buttler, Jennifer A.

2004-01-01

The program for which I am working at this summer is Propulsion and Power/Low Emissions Alternative Power (P&P/LEAP). It invests in a fundamental TRL 1-6 research and technology portfolio that will enable the future of: Alternative fuels and/or alternative propulsion systems, non-combustion (electric) propulsion systems. P&P/LEAP will identify and capitalize on the highest potential concepts generated both internal and external to the Agency. During my 2004 summer at NASA Glenn Research Center, I worked with my mentor Barbara Mader, in the Project Office with the Business Team completing various tasks for the project and personnel. The LEAP project is a highly matrixed organization. The Project Office is responsible for the goals advocacy and dollar (budget) of the LEAP project. The objectives of the LEAP Project are to discover new energy sources and develop unconventional engines and power systems directed towards greatly reduced emissions, enable new vehicle concepts for public mobility, new science missions and national security. The Propulsion and PowerLow Emissions Alternative Power directly supports the environmental, mobility, national security objectives of the Vehicle Systems Program and the Aeronautics Technology Theme. Technology deliverables include the demonstration through integrated ground tests, a constant volume combustor in an engine system, and UAV/small transport aircraft all electric power system. My mentor serves as a key member of the management team for the Aeropropulsion Research Program Office (ARPO). She has represented the office on numerous occasions, and is a member of a number of center-wide panels/teams, such as the Space management Committee and is chair to the Business Process Consolidation Team. She is responsible for the overall coordination of resources for the Propulsion and Power Project - from advocacy to implementation. The goal for my summer at NASA was to document processes and archive program documents from the past

Model for neural signaling leap statistics

Energy Technology Data Exchange (ETDEWEB)

Chevrollier, Martine; Oria, Marcos, E-mail: oria@otica.ufpb.br [Laboratorio de Fisica Atomica e Lasers Departamento de Fisica, Universidade Federal da ParaIba Caixa Postal 5086 58051-900 Joao Pessoa, Paraiba (Brazil)

2011-03-01

We present a simple model for neural signaling leaps in the brain considering only the thermodynamic (Nernst) potential in neuron cells and brain temperature. We numerically simulated connections between arbitrarily localized neurons and analyzed the frequency distribution of the distances reached. We observed qualitative change between Normal statistics (with T 37.5{sup 0}C, awaken regime) and Levy statistics (T = 35.5{sup 0}C, sleeping period), characterized by rare events of long range connections.

Gas, benefits and question marks. The Oklo reactors: 100 % natural. The Kyoto protocol: use it or lose it?. Small hydro power: a great leap forward. The energy mix of South Korea

International Nuclear Information System (INIS)

Anon.

2005-01-01

This issue of Alternatives newsletter contains a main press-kit about natural gas economics worldwide and 4 articles dealing with the Oklo natural reactor, the Kyoto protocol, the small hydro-power in China, and the energy mix of South Korea: 1 - 'Gas benefits and question marks': The world's most widely distributed fossil fuel, natural gas is also the fastest-growing energy source of the past thirty years. Its position as the fuel of choice in the global energy mix is due in large part to its many domestic and industrial applications. 2 - 'The Oklo reactors: 100% natural': Another look at this extraordinary 2 billion year-old phenomenon in words and pictures: the nuclear fission reaction that created the natural reactors of Gabon. 3 - 'The Kyoto Protocol: use it or lose it?': Nearly eight years after its signature, the Kyoto Protocol is still hotly debated. Two experts give us their views: Spencer Abraham, former U.S. Secretary for Energy, and Jean-Charles Hourcade of CIRED, the international center for research on the environment and development. 4 - 'Small hydro power: a great leap forward': The Chinese government has responded to the need for rural electrification with an aid program for the country's poorest cantons. Enter the small hydro plant in northern Guangxi province. 5 - 'The energy mix of South Korea': Faced with continuing strong economic growth and energy demand, South Korea has multiplied its projects, from hydropower to tidal power to nuclear and even hydrogen in the longer term

Leap Motion Device Used to Control a Real Anthropomorphic Gripper

Directory of Open Access Journals (Sweden)

Ionel Staretu

2016-06-01

Full Text Available This paper presents for the first time the use of the Leap Motion device to control an anthropomorphic gripper with five fingers. First, a description of the Leap Motion device is presented, highlighting its main functional characteristics, followed by testing of its use for capturing the movements of a human hand's fingers in different configurations. Next, the HandCommander soft module and the Interface Controller application are described. The HandCommander is a software module created to facilitate interaction between a human hand and the GraspIT virtual environment, and the Interface Controller application is required to send motion data to the virtual environment and to test the communication protocol. For the test, a prototype of an anthropomorphic gripper with five fingers was made, including a proper hardware system of command and control, which is briefly presented in this paper. Following the creation of the prototype, the command system performance test was conducted under real conditions, evaluating the recognition efficiency of the objects to be gripped and the efficiency of the command and control strategies for the gripping process. The gripping test is exemplified by the gripping of an object, such as a screw spanner. It was found that the command system, both in terms of capturing human hand gestures with the Leap Motion device and effective object gripping, is operational. Suggestive figures are presented as examples.

Measurement of plasma vitamin K1 (phylloquinone) and K2 (menaquinones-4 and -7) using HPLC-tandem mass spectrometry

NARCIS (Netherlands)

Riphagen, Ineke J; van der Molen, Jan C; van Faassen, Martijn; Navis, Gerjan; de Borst, Martin H; Muskiet, Frits A J; de Jong, Wilhelmina H A; Bakker, Stephan J L; Kema, Ido P

BACKGROUND: Given the growing interest in the health benefits of vitamin K, there is great need for development of new high-throughput methods for quantitative determination of vitamin K in plasma. We describe a simple and rapid method for measurement of plasma vitamin K1 (phylloquinone [PK]) and K2

The long-term forecast of Taiwan's energy supply and demand: LEAP model application

International Nuclear Information System (INIS)

Huang, Yophy; Bor, Yunchang Jeffrey; Peng, Chieh-Yu

2011-01-01

The long-term forecasting of energy supply and demand is an extremely important topic of fundamental research in Taiwan due to Taiwan's lack of natural resources, dependence on energy imports, and the nation's pursuit of sustainable development. In this article, we provide an overview of energy supply and demand in Taiwan, and a summary of the historical evolution and current status of its energy policies, as background to a description of the preparation and application of a Long-range Energy Alternatives Planning System (LEAP) model of Taiwan's energy sector. The Taiwan LEAP model is used to compare future energy demand and supply patterns, as well as greenhouse gas emissions, for several alternative scenarios of energy policy and energy sector evolution. Results of scenarios featuring 'business-as-usual' policies, aggressive energy-efficiency improvement policies, and on-schedule retirement of Taiwan's three existing nuclear plants are provided and compared, along with sensitivity cases exploring the impacts of lower economic growth assumptions. A concluding section provides an interpretation of the implications of model results for future energy and climate policies in Taiwan. - Research highlights: → The LEAP model is useful for international energy policy comparison. → Nuclear power plants have significant, positive impacts on CO 2 emission. → The most effective energy policy is to adopt demand-side management. → Reasonable energy pricing provides incentives for energy efficiency and conservation. → Financial crisis has less impact on energy demand than aggressive energy policy.

A procrastinator's guide to the Y2K problem.

Science.gov (United States)

Deveau, A G

1999-01-01

Your workplace has undoubtedly spent a great deal of time and money over the past few years on the Year 2000 (Y2K) problem. The focus of this article, however, is not on Y2K in the health care industry. Frankly, if your organization is not ready by now, it's too late. Your home computer, however, may be another story.

Study protocol: translating and implementing psychosocial interventions in aged home care the lifestyle engagement activity program (LEAP) for life

Science.gov (United States)

2013-01-01

Background Tailored psychosocial activity-based interventions have been shown to improve mood, behaviour and quality of life for nursing home residents. Occupational therapist delivered activity programs have shown benefits when delivered in home care settings for people with dementia. The primary aim of this study is to evaluate the effect of LEAP (Lifestyle Engagement Activity Program) for Life, a training and practice change program on the engagement of home care clients by care workers. Secondary aims are to evaluate the impact of the program on changes in client mood and behaviour. Methods/design The 12 month LEAP program has three components: 1) engaging site management and care staff in the program; 2) employing a LEAP champion one day a week to support program activities; 3) delivering an evidence-based training program to care staff. Specifically, case managers will be trained and supported to set meaningful social or recreational goals with clients and incorporate these into care plans. Care workers will be trained in and encouraged to practise good communication, promote client independence and choice, and tailor meaningful activities using Montessori principles, reminiscence, music, physical activity and play. LEAP Champions will be given information about theories of organisational change and trained in interpersonal skills required for their role. LEAP will be evaluated in five home care sites including two that service ethnic minority groups. A quasi experimental design will be used with evaluation data collected four times: 6-months prior to program commencement; at the start of the program; and then after 6 and 12 months. Mixed effect models will enable comparison of change in outcomes for the periods before and during the program. The primary outcome measure is client engagement. Secondary outcomes for clients are satisfaction with care, dysphoria/depression, loneliness, apathy and agitation; and work satisfaction for care workers. A process

EFEKTIFITAS IMPLEMENTASI MODEL QUANTUM LEAP DALAM MENINGKATKAN PANGSA PASAR

Directory of Open Access Journals (Sweden)

Suroyya Favourita H

2017-03-01

Full Text Available The aim of this research was to find out the difference of fund and credit market share before quantum leapmodel implementation and one year after implementation. This research had been done at the Bank X(Persero Tbk. in region 06 Surabaya. It consists of 29 branches as population and respondents. It used thetool of t-test and ANOVA to compare fund and credit market share before and after implementation. Theresult of this research showed that fund declines after implementation. This condition was strengthened byhypothesis test result. So, it was shown that there was no significance differences between before and afterimplementation. Company ability in credit contribution improved, the change was regarded as significantbetween before and after implementation. Based on market share data result, it could be concluded that thecompany ability in getting fund decline in average, so quantum leap model was not effectively improvesfund market share. In contrary, quantum leap model effectively improves credit market share.

Python Leap Second Management and Implementation of Precise Barycentric Correction (barycorrpy)

Science.gov (United States)

Kanodia, Shubham; Wright, Jason

2018-01-01

We announce barycorrpy (BCPy) , a Python implementation to calculate precise barycentric corrections well below the 1 cm/s level, following the algorithm of Wright and Eastman (2014). This level of precision is required in the search for 1 Earth mass planets in the Habitable Zones of Sun-like stars by the Radial Velocity (RV) method, where the maximum semi-amplitude is about 9 cm/s. We have developed BCPy to be used in the pipeline for the next generation Doppler Spectrometers - Habitable-zone Planet Finder (HPF) and NEID. In this work, we also develop an automated leap second management routine to improve upon the one available in Astropy. It checks for and downloads a new leap second file before converting from the UT time scale to TDB.

Trust as a Leap of Hope for Transaction Value

DEFF Research Database (Denmark)

Li, Peter Ping

2015-01-01

trustor’s propensity to trust as well as above and beyond trustor confident expectation of trustee’s trustworthiness (either due to trustee’s trait-like characters or due to institutional assurance). In this sense, trust should be reframed as a leap of hope to enhance transaction value by taking advantage...

Tool path planning of hole-making operations in ejector plate of injection mould using modified shuffled frog leaping algorithm

Directory of Open Access Journals (Sweden)

Amol M. Dalavi

2016-07-01

Full Text Available Optimization of hole-making operations in manufacturing industry plays a vital role. Tool travel and tool switch planning are the two major issues in hole-making operations. Many industrial applications such as moulds, dies, engine block, automotive parts etc. requires machining of large number of holes. Large number of machining operations like drilling, enlargement or tapping/reaming are required to achieve the final size of individual hole, which gives rise to number of possible sequences to complete hole-making operations on the part depending upon the location of hole and tool sequence to be followed. It is necessary to find the optimal sequence of operations which minimizes the total processing cost of hole-making operations. In this work, therefore an attempt is made to reduce the total processing cost of hole-making operations by applying relatively new optimization algorithms known as shuffled frog leaping algorithm and proposed modified shuffled frog leaping algorithm for the determination of optimal sequence of hole-making operations. An industrial application example of ejector plate of injection mould is considered in this work to demonstrate the proposed approach. The obtained results by the shuffled frog leaping algorithm and proposed modified shuffled frog leaping algorithm are compared with each other. It is seen from the obtained results that the results of proposed modified shuffled frog leaping algorithm are superior to those obtained using shuffled frog leaping algorithm.

QM/MM Calculations with deMon2k

Directory of Open Access Journals (Sweden)

Dennis R. Salahub

2015-03-01

Full Text Available The density functional code deMon2k employs a fitted density throughout (Auxiliary Density Functional Theory, which offers a great speed advantage without sacrificing necessary accuracy. Powerful Quantum Mechanical/Molecular Mechanical (QM/MM approaches are reviewed. Following an overview of the basic features of deMon2k that make it efficient while retaining accuracy, three QM/MM implementations are compared and contrasted. In the first, deMon2k is interfaced with the CHARMM MM code (CHARMM-deMon2k; in the second MM is coded directly within the deMon2k software; and in the third the Chemistry in Ruby (Cuby wrapper is used to drive the calculations. Cuby is also used in the context of constrained-DFT/MM calculations. Each of these implementations is described briefly; pros and cons are discussed and a few recent applications are described briefly. Applications include solvated ions and biomolecules, polyglutamine peptides important in polyQ neurodegenerative diseases, copper monooxygenases and ultra-rapid electron transfer in cryptochromes.

DESIGN REVIEW OF CAD MODELS USING A NUI LEAP MOTION SENSOR

Directory of Open Access Journals (Sweden)

GÎRBACIA Florin

2015-06-01

Full Text Available Natural User Interfaces (NUI is a relatively new area of research that aims to develop humancomputer interfaces, natural and intuitive, using voice commands, hand movements and gesture recognition, similar to communication between people which also implies body language and gestures. In this paper is presented a natural designed workspace which acquires the user's motion using a Leap Motion sensor and visualizes the CAD models using a CAVE-like 3D visualisation system. The user can modify complex CAD models using bimanual gesture commands in a 3D virtual environment. The developed bimanual gestures for rotate, pan, zoom and explode are presented. From the conducted experiments is established that Leap Motion NUI sensor provides an intuitive tool for design review of CAD models, performed even by users with no experience in CAD systems and virtual environments.

The long-term forecast of Taiwan's energy supply and demand: LEAP model application

Energy Technology Data Exchange (ETDEWEB)

Huang, Yophy, E-mail: yohuanghaka@gmail.com [Deptartment of Public Finance and Tax Administration, National Taipei College of Business, Taipei Taiwan, 10051 (China); Bor, Yunchang Jeffrey [Deptartment of Economics, Chinese Culture University, Yang-Ming-Shan, Taipei, 11114, Taiwan (China); Peng, Chieh-Yu [Statistics Department, Taoyuan District Court, No. 1 Fazhi Road, Taoyuan City 33053, Taiwan (China)

2011-11-15

The long-term forecasting of energy supply and demand is an extremely important topic of fundamental research in Taiwan due to Taiwan's lack of natural resources, dependence on energy imports, and the nation's pursuit of sustainable development. In this article, we provide an overview of energy supply and demand in Taiwan, and a summary of the historical evolution and current status of its energy policies, as background to a description of the preparation and application of a Long-range Energy Alternatives Planning System (LEAP) model of Taiwan's energy sector. The Taiwan LEAP model is used to compare future energy demand and supply patterns, as well as greenhouse gas emissions, for several alternative scenarios of energy policy and energy sector evolution. Results of scenarios featuring 'business-as-usual' policies, aggressive energy-efficiency improvement policies, and on-schedule retirement of Taiwan's three existing nuclear plants are provided and compared, along with sensitivity cases exploring the impacts of lower economic growth assumptions. A concluding section provides an interpretation of the implications of model results for future energy and climate policies in Taiwan. - Research Highlights: > The LEAP model is useful for international energy policy comparison. > Nuclear power plants have significant, positive impacts on CO{sub 2} emission. > The most effective energy policy is to adopt demand-side management. > Reasonable energy pricing provides incentives for energy efficiency and conservation. > Financial crisis has less impact on energy demand than aggressive energy policy.

Optimal inverse magnetorheological damper modeling using shuffled frog-leaping algorithm–based adaptive neuro-fuzzy inference system approach

Directory of Open Access Journals (Sweden)

Xiufang Lin

2016-08-01

Full Text Available Magnetorheological dampers have become prominent semi-active control devices for vibration mitigation of structures which are subjected to severe loads. However, the damping force cannot be controlled directly due to the inherent nonlinear characteristics of the magnetorheological dampers. Therefore, for fully exploiting the capabilities of the magnetorheological dampers, one of the challenging aspects is to develop an accurate inverse model which can appropriately predict the input voltage to control the damping force. In this article, a hybrid modeling strategy combining shuffled frog-leaping algorithm and adaptive-network-based fuzzy inference system is proposed to model the inverse dynamic characteristics of the magnetorheological dampers for improving the modeling accuracy. The shuffled frog-leaping algorithm is employed to optimize the premise parameters of the adaptive-network-based fuzzy inference system while the consequent parameters are tuned by a least square estimation method, here known as shuffled frog-leaping algorithm-based adaptive-network-based fuzzy inference system approach. To evaluate the effectiveness of the proposed approach, the inverse modeling results based on the shuffled frog-leaping algorithm-based adaptive-network-based fuzzy inference system approach are compared with those based on the adaptive-network-based fuzzy inference system and genetic algorithm–based adaptive-network-based fuzzy inference system approaches. Analysis of variance test is carried out to statistically compare the performance of the proposed methods and the results demonstrate that the shuffled frog-leaping algorithm-based adaptive-network-based fuzzy inference system strategy outperforms the other two methods in terms of modeling (training accuracy and checking accuracy.

The last glacial inception in continental northwestern Europe: characterization and timing of the Late Eemian Aridity Pulse (LEAP) recorded in multiple Belgian speleothems.

Science.gov (United States)

Vansteenberge, Stef; Verheyden, Sophie; Quinif, Yves; Genty, Dominique; Blamart, Dominique; Deprez, Maxim; Van Stappen, Jeroen; Cnudde, Veerle; Cheng, Hai; Edwards, R. Lawrence; Claeys, Philippe

2017-04-01

Interglacial-glacial transitions represent important turnovers in the climate system. In contrast with glacial terminations, they are described as a more gradual cooling. So far, the last interglacial has yielded a wealth of knowledge regarding climate dynamics during past warm periods. On top of the assumed gradual temperature drop starting at 119 ka, evidence for the presence of a drastic drying/cooling event in northern Europe has been observed. In lake records from Germany, a distinct shift in pollen assembly at 117.5 ka is interpreted as the consequence of a short dry event lasting 470 years, defined as the Late Eemian Aridity Pulse (LEAP, Sirocko et al., 2005). In a Belgian stalagmite from Han-sur-Lesse Cave, the LEAP is characterized by a 5‰ increase in δ13C occurring in just 200 years. The δ13C enrichment is dated at 117.5 ka and associated with a vegetation change above the cave, induced by a drying and/or cooling event (Vansteenberge et al., 2016). Also, within North Atlantic sediment cores, an increase in ice rafted debris was linked to the occurrence of a colder period at 117 ka (Irvali et al., 2016). Its coevality with the LEAP indicates a likely more regional extent than previously thought. Up to now, no independent chronology exists and little is known about the continental climatic expression of the LEAP. This study aims at 1) constructing an improved and independent chronology for the LEAP event, 2) characterizing this event in terms of its climatic expression and 3) placing the LEAP within the context of an interglacial-glacial transition. For this, two additional speleothems (Han-8, RSM-17) from two different Belgian caves (Han-sur-Lesse, Remouchamps) are added to the existing Han-9 dataset. Exceptionally high growth rates (0.5 mm yr-1) and a presumed annual layering of the RSM-17 sample enable an annual to decadal resolution to investigate the LEAP. U-Th age models covering the glacial inception are constructed with 25 dates on the three

The Characters of Leap Years in Qing Calendars (1644-1911)

Science.gov (United States)

Lu, Dalong

In Qing Dynasty (1644-1911) three different calendars had been put into use which titles are Xiyang Xinfa Lishu (Treatise on Astronomy and Calendrical Science according to the New Method in West 1645-1666) Yuzhi Lixiang Kaocheng (Compendium of Calendrical Science and Astronomy compiled by Imperial Order 1725-1742) and Yuzhi Lixiang Kaocheng Houbian (Sequel Compendium of Calendrical Science and Astronomy compiled by Imperial Order 1742-1911). The characters of leap years in the three calendars are different for the last one which is selected the year of 1723 as it epoch and named as Guimao Yuan Li. This calendar is based on the 33-year pattern of leap years (there is a rather exact accord between days and years over this interval with eight days being intercalated per 33 years) and is slightly different from the former two calendars. Therefore the calendars of Qing Dynasty complied by Western Jesuits and Chinese astronomers can be regarded as the remarkable achievements in the history of calendar in the world.

Draft genome sequence of Xylella fastidiosa subsp. fastidiosa strain Stag’s Leap

Science.gov (United States)

Xylella fastidiosa subsp. fastidiosa causes Pierce’s disease of grapevine. Presented here is the draft genome sequence of the Stag’s Leap strain, previously used in pathogenicity/virulence assays to evaluate grapevine germplasm bearing Pierce’s disease....

Unreal Interactive Puppet Game Development Using Leap Motion

Science.gov (United States)

Huang, An-Pin; Huang, Fay; Jhu, Jing-Siang

2018-04-01

This paper proposed a novel puppet play method utilizing recent technology. An interactive puppet game has been developed based on the theme of a famous Chinese classical novel. This project was implemented using Unreal Engine, which is a leading software of integrated tools for developers to design and build games. On the other hand, Leap Motion Controller is a sensor device for recognizing hand movements and gestures. It is commonly used in systems which require close-range finger-based user interaction. In order to manipulate puppets’ movements, the developed program employs the Leap Motion SDK, which provides a friendly way to add motion-controlled 3D hands to an Unreal game. The novelty of our project is to replace 3D model of rigged hands by two 3D humanoid rigged characters. The challenges of this task are two folds. First, the skeleton structure of a human hand and a humanoid character (i.e., puppets) are totally different. Making the puppets to follow the hand poses of the user and yet ensuring reasonable puppets’ movements has not been discussed in the literatures nor in the developer forums. Second, there are only a limited number of built-in recognizable hand gestures. More recognizable hand gestures need to be created for the interactive game. This paper reports the proposed solutions to these challenges.

Effects of Geometry and Kinematics on Animals Leaping Out of Water

Science.gov (United States)

Chang, Brian; Myeong, Jihye; Virot, Emmanuel; Kim, Ho-Young; Jung, Sunghwan

2017-11-01

Leaping out of water is a phenomenon exhibited by a variety of aquatic and semi-aquatic animals, such as frogs and whales. In this study, we aim to elucidate the effects of geometric and kinematic conditions on the propulsive and drag force required for an animal to jump through the water interface. A simple mechanism was designed to measure the propulsive thrust produced by a flapping appendage. In a separate experiment to measure the opposing drag, simplified models of animals are 3D printed and fitted with pressure sensors. The model is accelerated from rest and covers a range of Re from 103 to 105. Using a high-speed camera and pressure sensors, we observed a deformation of the free surface prior to water exit, and correlated this to the drag force. Finally, we discuss a scaling law to describe the general physics which allow animals to leap out of water. NSF EAPSI.

Medium- and Long-term Prediction of LOD Change by the Leap-step Autoregressive Model

Science.gov (United States)

Wang, Qijie

2015-08-01

The accuracy of medium- and long-term prediction of length of day (LOD) change base on combined least-square and autoregressive (LS+AR) deteriorates gradually. Leap-step autoregressive (LSAR) model can significantly reduce the edge effect of the observation sequence. Especially, LSAR model greatly improves the resolution of signals’ low-frequency components. Therefore, it can improve the efficiency of prediction. In this work, LSAR is used to forecast the LOD change. The LOD series from EOP 08 C04 provided by IERS is modeled by both the LSAR and AR models. The results of the two models are analyzed and compared. When the prediction length is between 10-30 days, the accuracy improvement is less than 10%. When the prediction length amounts to above 30 day, the accuracy improved obviously, with the maximum being around 19%. The results show that the LSAR model has higher prediction accuracy and stability in medium- and long-term prediction.

Virtual reality-based assessment of basic laparoscopic skills using the Leap Motion controller.

Science.gov (United States)

Lahanas, Vasileios; Loukas, Constantinos; Georgiou, Konstantinos; Lababidi, Hani; Al-Jaroudi, Dania

2017-12-01

The majority of the current surgical simulators employ specialized sensory equipment for instrument tracking. The Leap Motion controller is a new device able to track linear objects with sub-millimeter accuracy. The aim of this study was to investigate the potential of a virtual reality (VR) simulator for assessment of basic laparoscopic skills, based on the low-cost Leap Motion controller. A simple interface was constructed to simulate the insertion point of the instruments into the abdominal cavity. The controller provided information about the position and orientation of the instruments. Custom tools were constructed to simulate the laparoscopic setup. Three basic VR tasks were developed: camera navigation (CN), instrument navigation (IN), and bimanual operation (BO). The experiments were carried out in two simulation centers: MPLSC (Athens, Greece) and CRESENT (Riyadh, Kingdom of Saudi Arabia). Two groups of surgeons (28 experts and 21 novices) participated in the study by performing the VR tasks. Skills assessment metrics included time, pathlength, and two task-specific errors. The face validity of the training scenarios was also investigated via a questionnaire completed by the participants. Expert surgeons significantly outperformed novices in all assessment metrics for IN and BO (p assessment of basic laparoscopic skills. The proposed system allowed the evaluation of dexterity of the hand movements. Future work will involve comparison studies with validated simulators and development of advanced training scenarios on current Leap Motion controller.

Touch-free, gesture-based control of medical devices and software based on the leap motion controller.

Science.gov (United States)

Mauser, Stanislas; Burgert, Oliver

2014-01-01

There are several intra-operative use cases which require the surgeon to interact with medical devices. We used the Leap Motion Controller as input device and implemented two use-cases: 2D-Interaction (e.g. advancing EPR data) and selection of a value (e.g. room illumination brightness). The gesture detection was successful and we mapped its output to several devices and systems.

Nucleoli in human early erythroblasts (K2, K1, K1/2 cells).

Science.gov (United States)

Smetana, K; Jirásková, I; Klamová, H

2005-01-01

Human early erythroid precursors classified according to the nuclear size were studied to provide information on nucleoli in these cells using simple cytochemical procedures for demonstration of RNA and proteins of silver-stained nucleolar organizers. K2 cells with nuclear diameter larger than 13 microm and K1 cells with nuclear diameter larger than 9 microm corresponding to proerythroblasts and macroblasts (large basophilic erythroblasts) mostly possessed large irregularly shaped nucleoli with multiple fibrillar centres representing "active nucleoli". K1/2 cells with nuclear diameter smaller than 9 microm corresponding to small basophilic erythroblasts were usually characterized by the presence of micronucleoli representing "inactive nucleolar types". On the other hand, a few K1/2 cells contained large nucleoli with multiple fibrillar centres similar to those present in K2 cells and thus appeared as "microproerythroblasts". The nucleolar asynchrony expressed by the presence of large irregularly shaped nucleoli with multiple nucleoli (active nucleoli) and ring-shaped nucleoli (resting nucleoli) in one and the same nucleus of K2 or K1 cells was not exceptional and might reflect a larger resistance of these cells to negative factors influencing the erythropoiesis. The intranucleolar translocation of silver-stained nucleolus organized regions was noted in K2 cells and might indicate the premature aging of these cells without further differentiation. More studies, however, are required in this direction.

Draft Genome Sequence of Xylella fastidiosa subsp. fastidiosa Strain Stag?s Leap

OpenAIRE

Chen, J.; Wu, F.; Zheng, Z.; Deng, X.; Burbank, L. P.; Stenger, D. C.

2016-01-01

Xylella fastidiosa subsp. fastidiosa causes Pierce?s disease of grapevine. Presented here is the draft genome sequence of the Stag?s Leap strain, previously used in pathogenicity/virulence assays to evaluate grapevine germplasm bearing Pierce?s disease resistance and a phenotypic assessment of knockout mutants to determine gene function.

Nonlinear Rayleigh wave inversion based on the shuffled frog-leaping algorithm

Science.gov (United States)

Sun, Cheng-Yu; Wang, Yan-Yan; Wu, Dun-Shi; Qin, Xiao-Jun

2017-12-01

At present, near-surface shear wave velocities are mainly calculated through Rayleigh wave dispersion-curve inversions in engineering surface investigations, but the required calculations pose a highly nonlinear global optimization problem. In order to alleviate the risk of falling into a local optimal solution, this paper introduces a new global optimization method, the shuffle frog-leaping algorithm (SFLA), into the Rayleigh wave dispersion-curve inversion process. SFLA is a swarm-intelligence-based algorithm that simulates a group of frogs searching for food. It uses a few parameters, achieves rapid convergence, and is capability of effective global searching. In order to test the reliability and calculation performance of SFLA, noise-free and noisy synthetic datasets were inverted. We conducted a comparative analysis with other established algorithms using the noise-free dataset, and then tested the ability of SFLA to cope with data noise. Finally, we inverted a real-world example to examine the applicability of SFLA. Results from both synthetic and field data demonstrated the effectiveness of SFLA in the interpretation of Rayleigh wave dispersion curves. We found that SFLA is superior to the established methods in terms of both reliability and computational efficiency, so it offers great potential to improve our ability to solve geophysical inversion problems.

The Lifestyle Engagement Activity Program (LEAP): Implementing Social and Recreational Activity into Case-Managed Home Care.

Science.gov (United States)

Low, Lee-Fay; Baker, Jessica Rose; Harrison, Fleur; Jeon, Yun-Hee; Haertsch, Maggie; Camp, Cameron; Skropeta, Margaret

2015-12-01

The Lifestyle Engagement Activity Program (LEAP) incorporates social support and recreational activities into case-managed home care. This study's aim was to evaluate the effect of LEAP on engagement, mood, and behavior of home care clients, and on case managers and care workers. Quasi-experimental. Five Australian aged home care providers, including 2 specializing in care for ethnic minorities. Clients (n = 189) from 5 home care providers participated. The 12-month program had 3 components: (1) engaging support of management and staff; (2) a champion to drive practice change; (3) staff training. Case managers were trained to set meaningful social and/or recreational goals during care planning. Care workers were trained in good communication, to promote client independence and choice, and in techniques such as Montessori activities, reminiscence, music, physical activity, and humor. Data were collected 6 months before program commencement, at baseline, and 6 and 12 months. The Homecare Measure of Engagement Staff report and Client-Family interview were primary outcomes. Secondary outcomes were the Cohen-Mansfield Agitation Inventory; apathy, dysphoria, and agitation subscales of the Neuropsychiatric Inventory-Clinician Rating; the geriatric depression scale; UCLA loneliness scale; and home care satisfaction scale. Staff provided information on confidence in engaging clients and the Utrecht Work Engagement Scale. Twelve months after program commencement, clients showed a significant increase in self- or family-reported client engagement (b = 5.39, t[113.09] = 3.93, P recreationally engage clients (b = 0.52, t(21.33) = 2.80, P = .011, b = 0.29, t(198.69) = 2.58, P = .011, respectively). There were no significant changes in care worker-rated client engagement or client or family self-complete measures of depression or loneliness (P > .05). Client and family self-rated apathy increased over 12 months (b = 0.04, t(43.36) = 3.06, P = .004; b = 3.63, t(34.70) = 2.20, P

Towards automatic global error control: Computable weak error expansion for the tau-leap method

KAUST Repository

Karlsson, Peer Jesper; Tempone, Raul

2011-01-01

This work develops novel error expansions with computable leading order terms for the global weak error in the tau-leap discretization of pure jump processes arising in kinetic Monte Carlo models. Accurate computable a posteriori error approximations are the basis for adaptive algorithms, a fundamental tool for numerical simulation of both deterministic and stochastic dynamical systems. These pure jump processes are simulated either by the tau-leap method, or by exact simulation, also referred to as dynamic Monte Carlo, the Gillespie Algorithm or the Stochastic Simulation Slgorithm. Two types of estimates are presented: an a priori estimate for the relative error that gives a comparison between the work for the two methods depending on the propensity regime, and an a posteriori estimate with computable leading order term. © de Gruyter 2011.

Hang in there! Quick takes on Y2K.

Science.gov (United States)

Lewis, A G; Weingart, V S

1998-11-01

Cliffhangers in movies are great fun. But not in real life. Think Y2K. If you haven't scripted a way to beat the millennium bug, there are workable solutions that can be created in six months. Here's how to begin production: Prioritize activities, expenditures and resources, and apply them to the most vital problems first.

Outcomes and challenges of global high-resolution non-hydrostatic atmospheric simulations using the K computer

Science.gov (United States)

Satoh, Masaki; Tomita, Hirofumi; Yashiro, Hisashi; Kajikawa, Yoshiyuki; Miyamoto, Yoshiaki; Yamaura, Tsuyoshi; Miyakawa, Tomoki; Nakano, Masuo; Kodama, Chihiro; Noda, Akira T.; Nasuno, Tomoe; Yamada, Yohei; Fukutomi, Yoshiki

2017-12-01

This article reviews the major outcomes of a 5-year (2011-2016) project using the K computer to perform global numerical atmospheric simulations based on the non-hydrostatic icosahedral atmospheric model (NICAM). The K computer was made available to the public in September 2012 and was used as a primary resource for Japan's Strategic Programs for Innovative Research (SPIRE), an initiative to investigate five strategic research areas; the NICAM project fell under the research area of climate and weather simulation sciences. Combining NICAM with high-performance computing has created new opportunities in three areas of research: (1) higher resolution global simulations that produce more realistic representations of convective systems, (2) multi-member ensemble simulations that are able to perform extended-range forecasts 10-30 days in advance, and (3) multi-decadal simulations for climatology and variability. Before the K computer era, NICAM was used to demonstrate realistic simulations of intra-seasonal oscillations including the Madden-Julian oscillation (MJO), merely as a case study approach. Thanks to the big leap in computational performance of the K computer, we could greatly increase the number of cases of MJO events for numerical simulations, in addition to integrating time and horizontal resolution. We conclude that the high-resolution global non-hydrostatic model, as used in this five-year project, improves the ability to forecast intra-seasonal oscillations and associated tropical cyclogenesis compared with that of the relatively coarser operational models currently in use. The impacts of the sub-kilometer resolution simulation and the multi-decadal simulations using NICAM are also reviewed.

Multilevel Drift-Implicit Tau-Leap

KAUST Repository

Ben Hammouda, Chiheb

2016-01-06

The dynamics of biochemical reactive systems with small copy numbers of one or more reactant molecules is dominated by stochastic effects. For those systems, discrete state-space and stochastic simulation approaches were proved to be more relevant than continuous state-space and deterministic ones. In systems characterized by having simultaneously fast and slowtimescales, the existing discrete space-state stochastic path simulation methods such as the stochastic simulation algorithm (SSA) and the explicit tauleap method can be very slow. Implicit approximations were developed in the literature to improve numerical stability and provide efficient simulation algorithms for those systems. In this work, we propose an efficient Multilevel Monte Carlo method in the spirit of the work by Anderson and Higham (2012) that uses drift-implicit tau-leap approximations at levels where the explicit tauleap method is not applicable due to numerical stability issues. We present numerical examples that illustrate the performance of the proposed method.

Chemical and Electrochemical Asymmetric Dihydroxylation of Olefins in I(2)-K(2)CO(3)-K(2)OsO(2)(OH)(4) and I(2)-K(3)PO(4)/K(2)HPO(4)-K(2)OsO(2)(OH)(4) Systems with Sharpless' Ligand.

Science.gov (United States)

Torii, Sigeru; Liu, Ping; Bhuvaneswari, Narayanaswamy; Amatore, Christian; Jutand, Anny

1996-05-03

Iodine-assisted chemical and electrochemical asymmetric dihydroxylation of various olefins in I(2)-K(2)CO(3)-K(2)OsO(2)(OH)(4) and I(2)-K(3)PO(4)/K(2)HPO(4)-K(2)OsO(2)(OH)(4) systems with Sharpless' ligand provided the optically active glycols in excellent isolated yields and high enantiomeric excesses. Iodine (I(2)) was used stoichiometrically for the chemical dihydroxylation, and good results were obtained with nonconjugated olefins in contrast to the case of potassium ferricyanide as a co-oxidant. The potentiality of I(2) as a co-oxidant under stoichiometric conditions has been proven to be effective as an oxidizing mediator in electrolysis systems. Iodine-assisted asymmetric electro-dihydroxylation of olefins in either a t-BuOH/H(2)O(1/1)-K(2)CO(3)/(DHQD)(2)PHAL-(Pt) or t-BuOH/H(2)O(1/1)-K(3)PO(4)/K(2)HPO(4)/(DHQD)(2)PHAL-(Pt) system in the presence of potassium osmate in an undivided cell was investigated in detail. Irrespective of the substitution pattern, all the olefins afforded the diols in high yields and excellent enantiomeric excesses. A plausible mechanism is discussed on the basis of cyclic voltammograms as well as experimental observations.

EDITORIAL: Quanta and leaps

Science.gov (United States)

Dobson, Ken

2000-11-01

oscillating light `waves' had to be quantized as well. Several articles in this issue of Physics Education celebrate the first year of the quantum, 1900. I am grateful and beholden to Board Member and co-editor Gren Ireson for his contacts and nomination of the various contributors. It does seem strange, however, a full century after its discovery full of its amazing success that the essential quantum nature of practically everything is still kept hidden from school students, in the UK at least. Let's see what happens in the coming century. Now for another quantum leap. This is the last issue of Physics Education that I shall have the honour of editing. In fact, I shall leap into historical obscurity as the very last honorary editor. Great efforts by your Editorial Board - over a fair number of years! - have resulted in a radical reorganizing of both the journal and the way it is produced. It's been an interesting five years, a time of falling numbers but quite radical innovations in post-16 physics education. IoPP and the IoP are working together to revitalize what may have been seen by many as a staid if respectable and authoritative publication. We shall keep the authority and even respectability but hope to liven things up a bit. The new editor is Kerry Parker of Sheffield College. She will take on a stronger role than I and my predecessors have had, and will be working at IoPP in Bristol two days a week. There are many obvious advantages in this, and I look forward to seeing the new design and approach that will start with the January 2000 issue. So, it's goodbye from me - and also from the unsung heroine of Physics Education for even longer. Managing Editor Dr Jill Membrey has been doing the really hard work at Bristol for many years, but is now moving on to other things at IoPP. I am extremely grateful for the highly professional care and support she has provided for myself and the Editorial Board over the years. The new Managing Editor is Andrea Pomroy, who arrives at

Flying fish accelerate at 5 G to leap from the water surface

Science.gov (United States)

Yang, Patricia; Phonekeo, Sulisay; Xu, Ke; Chang, Shui-Kai; Hu, David

2013-11-01

Flying fish can both swim underwater and glide in air. Transitioning from swimming to gliding requires penetration of the air-water interface, or breaking the ``surface tension barrier,'' a formidable task for juvenile flying fish measuring 1 to 5 cm in length. In this experimental investigation, we use high-speed videography to characterize the kinematics of juvenile flying fish as they leap from the water surface. During this process, which lasts 0.05 seconds, flying fish achieve body accelerations of 5 times earth's gravity and gliding speeds of 1.3 m/s, an order of magnitude higher than their steady swimming speed. We rationalize this anomalously high speed on the basis of the hydrodynamic and surface tension forces and torques experienced by the fish. Specifically, leaping fish experience skin friction forces only on the submerged part of their body, permitting them to achieve much higher speeds than in steady underwater swimming. We also perform experiments using a towed flying fish mimc to determine optimality of various parameters in this process, including body angle and start position with respect to the water surface.

Leap Motion Gesture Control With Carestream Software in the Operating Room to Control Imaging: Installation Guide and Discussion.

Science.gov (United States)

Pauchot, Julien; Di Tommaso, Laetitia; Lounis, Ahmed; Benassarou, Mourad; Mathieu, Pierre; Bernot, Dominique; Aubry, Sébastien

2015-12-01

Nowadays, routine cross-sectional imaging viewing during a surgical procedure requires physical contact with an interface (mouse or touch-sensitive screen). Such contact risks exposure to aseptic conditions and causes loss of time. Devices such as the recently introduced Leap Motion (Leap Motion Society, San Francisco, CA), which enables interaction with the computer without any physical contact, are of wide interest in the field of surgery, but configuration and ergonomics are key challenges for the practitioner, imaging software, and surgical environment. This article aims to suggest an easy configuration of Leap Motion on a PC for optimized use with Carestream Vue PACS v11.3.4 (Carestream Health, Inc, Rochester, NY) using a plug-in (to download at https://drive.google.com/open?id=0B_F4eBeBQc3yNENvTXlnY09qS00&authuser=0) and a video tutorial (https://www.youtube.com/watch?v=yVPTgxg-SIk). Videos of surgical procedure and discussion about innovative gesture control technology and its various configurations are provided in this article. © The Author(s) 2015.

Y2K

OpenAIRE

Stephanie Schmitt-Grohe; Martin Uribe

1999-01-01

This paper studies, within a general equilibrium model, the dynamics of Y2K-type shocks: anticipated, permanent losses in output whose magnitude can be lessened by investing resources in advance. The implied dynamics replicate three observed characteristics of those triggered by the Y2K bug: (1) Precautionary investment: investment in solving the Y2K problem begins before the year 2000; (2) Investment delay: although economic agents have been aware of the Y2K problem since the 1960s, investme...

Development of excavator training simulator using leap motion controller

Science.gov (United States)

Fahmi, F.; Nainggolan, F.; Andayani, U.; Siregar, B.

2018-03-01

Excavator is a heavy machinery that is used for many industries purposes. Controlling the excavator is not easy. Its operator has to be trained well in many skills to make sure it is safe, effective, and efficient while using the excavator. In this research, we proposed a virtual reality excavator simulator supported by a device called Leap Motion Controller that supports finger and hand motions as an input. This prototype will be developed than in the virtual reality environment to give a more real sensing to the user.

Results from K2K experiment

International Nuclear Information System (INIS)

Yanagisawa, Chiaki

2001-01-01

The K2K experiment is the first long baseline neutrino oscillation experiment at KEK and at Kamioka, Japan. This is a brief summary of the K2K experiment in the first year of running from June 1999 to June 2000. The major result is that for the first time in human history artificially produced neutrinos by an accelerator are detected at a long distance of 250km from the production points. A brief introduction, the detector performance and the some analysis results are presented. The analysis results are based on the data corresponding to the integrated beam intesnsity of 2.29 x 10 19 pot

China's "Great Leap" toward Madison Avenue.

Science.gov (United States)

Anderson, Michael H.

1981-01-01

Examines the expanding use of advertising in China. Discusses the impact of transnational corporations in communication and other areas on the development of China, and the implications that the introduction of advertising has for China's role as one of the models for developing countries. (JMF)

Y2K

OpenAIRE

Schmitt-Grohe, Stephanie; Uribe, Martin

1998-01-01

As the millennium draws to an end, the threat posed by the Year 2000 (Y2K) problem is inducing vast private and public spending on its remediation. In this paper, we model the Y2K problem as an anticipated, permanent loss in output whose magnitude can be lessened by investing resources in advance. We embed the Y2K problem into a dynamic general equilibrium framework and show that our model replicates three observed characteristics of the dynamics triggered by the Y2K bug: (1) Precautionary in...

Monitoring urban transport air pollution and energy demand in Rawalpindi and Islamabad using leap model

Energy Technology Data Exchange (ETDEWEB)

Shabbir, Rabia; Ahmad, Sheikh Saeed [Department of Environmental Sciences, Fatima Jinnah Women University, Rawalpindi (Pakistan)

2010-05-15

A research associated with urban transportation was carried out in Rawalpindi and Islamabad to analyze the status of emission of air pollutants and energy demands. The study included a discussion of past trends and future scenarios in order to reduce the future emissions. A simple model of passenger transport has been developed using computer based software called Long-Range Energy Alternatives Planning System (LEAP). The LEAP model was used to estimate total energy demand and the vehicular emissions for the base year 2000 and extrapolated till 2030 for the future predictions. Transport database in Rawalpindi and Islamabad, together with fuel consumption values for the vehicle types and emission factors of NO{sub x}, SO{sub 2} and PM{sub 10} corresponding to the actual vehicle types, formed the basis of the transport demand, energy consumption and total emission calculations. Apart from base scenario, the model was run under three alternative scenarios to study the impact of different urban transport policy initiatives that would reduce energy demand and emissions in transport sector of Rawalpindi and Islamabad. The prime objective was to arrive at an optimal transport policy, which limits the future growth of fuel consumption as well as air pollution. (author)

Molecular Aspects of Structure, Gating, and Physiology of pH-Sensitive Background K2P and Kir K+-Transport Channels

Science.gov (United States)

Sepúlveda, Francisco V.; Pablo Cid, L.; Teulon, Jacques; Niemeyer, María Isabel

2015-01-01

K+ channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K+ channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K+ homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by parietal cells in the stomach. K2P channels fulfill a crucial part in central chemoreception probably by virtue of their pH sensitivity and are central to adrenal secretion of aldosterone. Finally, some unorthodox behaviors of the selectivity filters of K2P channels might explain their normal and pathological functions. Although a great deal has been learned about structure, molecular details of gating, and physiological functions of K2P and Kir K+-transport channels, this has been only scratching at the surface. More molecular and animal studies are clearly needed to deepen our knowledge. PMID:25540142

Model of a 80 K liner vacuum system for the 4.2 K cold bore of the SSCL 20 TeV proton collider

International Nuclear Information System (INIS)

Turner, W.

1993-09-01

In this paper we discuss a model for an 80 K liner system for the beam tube vacuum of the Superconducting Super Collider (SSC). The liner is a coaxial perforated tube fitting inside the ∼4.2 K bore tube of the SSC magnet cryostats. A liner of this type is useful for pumping the gas desorbed by synchrotron radiation out of the view of the radiation and for decoupling the beam current from the 4.2 K refrigeration plant capacity. Addition of cryosorber on the bore tube (e.g., charcoal) greatly increases the H 2 sorption capacity compared to the bare metal surface, thus lengthening the time between beam tube warmups. The model equations are useful for estimating the performance of the beam tube vacuum and for defining the experimental information necessary to make a prediction. Some analysis is also presented for 4.2 K and 20 K liners and a simple 4.2 K beam tube without a liner

[A new human machine interface in neurosurgery: The Leap Motion(®). Technical note regarding a new touchless interface].

Science.gov (United States)

Di Tommaso, L; Aubry, S; Godard, J; Katranji, H; Pauchot, J

2016-06-01

Currently, cross-sectional imaging viewing is used in routine practice whereas the surgical procedure requires physical contact with an interface (mouse or touch-sensitive screen). This type of contact results in a risk of lack of aseptic control and causes loss of time. The recent appearance of devices such as the Leap Motion(®) (Leap Motion society, San Francisco, USA) a sensor which enables to interact with the computer without any physical contact is of major interest in the field of surgery. However, its configuration and ergonomics produce key challenges in order to adapt to the practitioner's requirements, the imaging software as well as the surgical environment. This article aims to suggest an easy configuration of the Leap Motion(®) in neurosurgery on a PC for an optimized utilization with Carestream(®) Vue PACS v11.3.4 (Carestream Health, Inc., Rochester, USA) using a plug-in (to download at: https://drive.google.com/?usp=chrome_app#folders/0B_F4eBeBQc3ybElEeEhqME5DQkU) and a video tutorial (https://www.youtube.com/watch?v=yVPTgxg-SIk). Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Identification of a low copy number plasmid in Xylella fastidiosa Strain Stag’s Leap

Science.gov (United States)

Xylella fastidiosa (Xf) causes Pierce’s Disease (PD) in grapevine. The Stag’s Leap strain is known for its high virulence level and is a model for PD research. Research on Xf has been difficult due to its nutritional fastidiousness. One difficult research issue is the low copy number plasmid. Plasmi...

K-n and K-p elastic scattering in K-d collisions from 1.2 to 2.2 GeV/c

International Nuclear Information System (INIS)

Declais, Y.; Duchon, J.; Louvel, M.; Patry, J.-P.; Seguinot, J.; Baillon, P.; Bruman, C.; Ferro-Luzzi, M.; Perreau, J.-M.; Ypsilantis, T.

1977-01-01

This report contains the detailed description of an experiment which has determined the differential cross section of the K - n→K - n elastic scattering reaction. The results are 12 angular distributions spanning the K - n c.m. energy interval from approximately 1.86 to approximately 2.32 GeV. The measurements have been performed at the CERN PS using a beam of negative kaons with momenta from 1.2 to 2.2 GeV/c incident on a liquid deuterium target. By means of electronic apparatus the process K - d→K - n psub(s) was identified and recorded; this process is basically the same as the K - n elastic reaction insofar as the spectator proton psub(s) has low momentum. The elastic reaction was derived from the above process by taking into account the Fermi motion of the target neutron and by introducing the appropriate corrections to compensate for the effects due to the composite nature of the neutron (double-scattering, final state interaction). These results, constituting the first extensive collection of data on the pure isospin 1 anti KN state have been used in conjunction with other data in a preliminary partial wave analysis of the anti KN elastic system over the c.m. energy range from 1.84 to 2.23 GeV. Mainly for testing purposes, a similar amount of data has been collected for the K - p elastic reaction also from K - d collisions (K - d→K - p nsub(s)). (Auth.)

Acoustic resonator providing fixed points of temperature between 0.1 and 2 K

International Nuclear Information System (INIS)

Salmela, Anssi; Tuoriniemi, Juha; Pentti, Elias; Sebedash, Alexander; Rysti, Juho

2009-01-01

Below 2 K the speed of second sound in mixtures of liquid 3 He and 4 He first increases to a maximum of 30-40 m/s at about 1 K and then decreases again at lower temperatures to values below 15 m/s. The exact values depend on the concentration and pressure of the mixture. This can be exploited to provide fixed points in temperature by utilizing a resonator with appropriate dimensions and frequency to excite standing waves in the resonator cavity filled with helium mixture. We demonstrate that commercially mass produced quartz tuning forks can be used for this purpose. They are meant for frequency standards operating at 32 kHz. Their dimensions are typically of order 1 mm matching the wavelength of the second sound in helium mixtures at certain values of temperature. Due to the complicated geometry, we observe some 20 sharp acoustic resonances in the range 0.1l 2 K having temperature resolution of order 1 μK. The quartz resonators are cheap, compact, simple to implement, easy to measure with great accuracy, and, above all, they are not sensitive to magnetic field, which is a great advantage compared to fixed point devices based on superconductivity transitions. The reproducibility of the resonance pattern upon thermal cycling remains to be verified.

K2-60b and K2-107b. A Sub-Jovian and a Jovian Planet from the K2 Mission

International Nuclear Information System (INIS)

Eigmüller, Philipp; Csizmadia, Szilard; Smith, Alexis M. S.; Cabrera, Juan; Erikson, Anders; Gandolfi, Davide; Barragán, Oscar; Persson, Carina M.; Fridlund, Malcolm; Donati, Paolo; Cusano, Felice; Korth, Judith; Grziwa, Sascha; Prieto-Arranz, Jorge; Nespral, David; Deeg, Hans J.; Saario, Joonas; Cochran, William D.; Endl, Michael; Guenther, Eike W.

2017-01-01

We report the characterization and independent detection of K2-60b, as well as the detection and characterization of K2-107b, two transiting hot gaseous planets from the K2 space mission. We confirm the planetary nature of the two systems and determine their fundamental parameters combining the K2 time-series data with FIES@NOT and HARPS-N@TNG spectroscopic observations. K2-60b has a radius of 0.683 ± 0.037 R Jup and a mass of 0.426 ± 0.037 M Jup and orbits a G4 V star with an orbital period of 3.00267 ± 0.00006 days. K2-107b has a radius of 1.44 ± 0.15 R Jup and a mass of 0.84 ± 0.08 M Jup and orbits an F9 IV star every 3.31392 ± 0.00002 days. K2-60b is among the few planets at the edge of the so-called “desert” of short-period sub-Jovian planets. K2-107b is a highly inflated Jovian planet orbiting an evolved star about to leave the main sequence.

K2-60b and K2-107b. A Sub-Jovian and a Jovian Planet from the K2 Mission

Energy Technology Data Exchange (ETDEWEB)

Eigmüller, Philipp; Csizmadia, Szilard; Smith, Alexis M. S.; Cabrera, Juan; Erikson, Anders [Institute of Planetary Research, German Aerospace Center, Rutherfordstrasse 2, D-12489 Berlin (Germany); Gandolfi, Davide; Barragán, Oscar [Dipartimento di Fisica, Universitá di Torino, via P. Giuria 1, I-10125 Torino (Italy); Persson, Carina M.; Fridlund, Malcolm [Department of Earth and Space Sciences, Chalmers University of Technology, Onsala Space Observatory, SE-439 92 Onsala (Sweden); Donati, Paolo; Cusano, Felice [INAF—Osservatorio Astronomico di Bologna, Via Ranzani, 1, I-40127, Bologna (Italy); Korth, Judith; Grziwa, Sascha [Rheinisches Institut für Umweltforschung an der Universität zu Köln, Aachener Strasse 209, D-50931 Köln (Germany); Prieto-Arranz, Jorge; Nespral, David; Deeg, Hans J. [Instituto de Astrofísica de Canarias, E-38205 La Laguna, Tenerife (Spain); Saario, Joonas [Nordic Optical Telescope, Apartado 474, E-38700, Santa Cruz de La Palma (Spain); Cochran, William D.; Endl, Michael [Department of Astronomy and McDonald Observatory, University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712 (United States); Guenther, Eike W. [Thüringer Landessternwarte Tautenburg, Sternwarte 5, D-07778 Tautenberg (Germany); and others

2017-03-01

We report the characterization and independent detection of K2-60b, as well as the detection and characterization of K2-107b, two transiting hot gaseous planets from the K2 space mission. We confirm the planetary nature of the two systems and determine their fundamental parameters combining the K2 time-series data with FIES@NOT and HARPS-N@TNG spectroscopic observations. K2-60b has a radius of 0.683 ± 0.037 R {sub Jup} and a mass of 0.426 ± 0.037 M {sub Jup} and orbits a G4 V star with an orbital period of 3.00267 ± 0.00006 days. K2-107b has a radius of 1.44 ± 0.15 R {sub Jup} and a mass of 0.84 ± 0.08 M {sub Jup} and orbits an F9 IV star every 3.31392 ± 0.00002 days. K2-60b is among the few planets at the edge of the so-called “desert” of short-period sub-Jovian planets. K2-107b is a highly inflated Jovian planet orbiting an evolved star about to leave the main sequence.

Spin-k/2-spin-k/2 SU(2) two-point functions on the torus

International Nuclear Information System (INIS)

Kirsch, Ingo; Kucharski, Piotr

2012-11-01

We discuss a class of two-point functions on the torus of primary operators in the SU(2) Wess-Zumino-Witten model at integer level k. In particular, we construct an explicit expression for the current blocks of the spin-(k)/(2)-spin-(k)/(2) torus two-point functions for all k. We first examine the factorization limits of the proposed current blocks and test their monodromy properties. We then prove that the current blocks solve the corresponding Knizhnik-Zamolodchikov-like differential equations using the method of Mathur, Mukhi and Sen.

Spin-k/2-spin-k/2 SU(2) two-point functions on the torus

Energy Technology Data Exchange (ETDEWEB)

Kirsch, Ingo [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Gruppe Theorie; Kucharski, Piotr [Warsaw Univ. (Poland). Inst. of Theoretical Physics

2012-11-15

We discuss a class of two-point functions on the torus of primary operators in the SU(2) Wess-Zumino-Witten model at integer level k. In particular, we construct an explicit expression for the current blocks of the spin-(k)/(2)-spin-(k)/(2) torus two-point functions for all k. We first examine the factorization limits of the proposed current blocks and test their monodromy properties. We then prove that the current blocks solve the corresponding Knizhnik-Zamolodchikov-like differential equations using the method of Mathur, Mukhi and Sen.

The system K2NbF7-K2TiF6-KCl

International Nuclear Information System (INIS)

Kamenskaya, L.A.; Matveev, A.M.

1984-01-01

Using visual-polythermal and thermographical methods the ternary system K 2 NbF 7 -K 2 TiE 6 -KCl has been studied. Crystallization fields of initial components and the field of solid solutions of double compounds K 3 NbClF 7 and K 3 TiClF 6 are outlined. Ternary eutectics at 654 deg C, having the composition K 2 NbF 6 -41, K 2 TiP 6 -41, KCl-18 mol.%, is determined. Potassium fluoroniobate and fluorotitanate form continuous solid solutions unstable in the presence of the third component, potassium chloride

Underwater hearing in the great cormorant (Phalacrocorax carbo sinensis)

DEFF Research Database (Denmark)

Hansen, Kirstin Anderson; Larsen, Ole Næsbye; Wahlberg, Magnus

2016-01-01

The underwater hearing threshold of a great cormorant (Phalacrocroax carbo sinensis) was measured at 2 kHz using psychophysical methods. Previous in-air and underwater testing suggests that cormorants have rather poor in-air hearing compared to other birds of similar size (Johansen, 2016). Prelim......The underwater hearing threshold of a great cormorant (Phalacrocroax carbo sinensis) was measured at 2 kHz using psychophysical methods. Previous in-air and underwater testing suggests that cormorants have rather poor in-air hearing compared to other birds of similar size (Johansen, 2016...

Leaping shampoo glides on a lubricating air layer

Science.gov (United States)

Lee, S.; Li, E. Q.; Marston, J. O.; Bonito, A.; Thoroddsen, S. T.

2013-06-01

When a stream of shampoo is fed onto a pool in one's hand, a jet can leap sideways or rebound from the liquid surface in an intriguing phenomenon known as the Kaye effect. Earlier studies have debated whether non-Newtonian effects are the underlying cause of this phenomenon, making the jet glide on top of a shear-thinning liquid layer, or whether an entrained air layer is responsible. Herein we show unambiguously that the jet slides on a lubricating air layer. We identify this layer by looking through the pool liquid and observing its rupture into fine bubbles. The resulting microbubble sizes suggest this air layer is of submicron thickness. This thickness estimate is also supported by the tangential deceleration of the jet during the rebounding.

Leaping shampoo glides on a lubricating air layer

KAUST Repository

Lee, S.

2013-06-10

When a stream of shampoo is fed onto a pool in one\\'s hand, a jet can leap sideways or rebound from the liquid surface in an intriguing phenomenon known as the Kaye effect. Earlier studies have debated whether non-Newtonian effects are the underlying cause of this phenomenon, making the jet glide on top of a shear-thinning liquid layer, or whether an entrained air layer is responsible. Herein we show unambiguously that the jet slides on a lubricating air layer. We identify this layer by looking through the pool liquid and observing its rupture into fine bubbles. The resulting microbubble sizes suggest this air layer is of submicron thickness. This thickness estimate is also supported by the tangential deceleration of the jet during the rebounding.

Leaping shampoo glides on a lubricating air layer

KAUST Repository

Lee, S.; Li, Erqiang; Marston, J. O.; Bonito, A.; Thoroddsen, Sigurdur T

2013-01-01

When a stream of shampoo is fed onto a pool in one's hand, a jet can leap sideways or rebound from the liquid surface in an intriguing phenomenon known as the Kaye effect. Earlier studies have debated whether non-Newtonian effects are the underlying cause of this phenomenon, making the jet glide on top of a shear-thinning liquid layer, or whether an entrained air layer is responsible. Herein we show unambiguously that the jet slides on a lubricating air layer. We identify this layer by looking through the pool liquid and observing its rupture into fine bubbles. The resulting microbubble sizes suggest this air layer is of submicron thickness. This thickness estimate is also supported by the tangential deceleration of the jet during the rebounding.

First principles simulation on the K0.8Fe2Se2 high-temperature structural superconductor

International Nuclear Information System (INIS)

Guo, Rui; Yang, Shizhong; Khosravi, Ebrahim; Zhao, Guang-Lin; Bagayoko, Diola

2013-01-01

Highlights: • The superconductor K 0.8 Fe 2 Se 2 super cell size, shape, and atomic positions are fully optimized using first principles density functional theory method. • Each K atom donates 0.8 |e| with K vacancies in the supercell, each Fe atom donates 0.4 |e|, while each Se atom gains 0.7 |e| ∼ 0.8 |e|. • Fe atoms show magnetic moment fluctuation and possible strong spin-orbital coupling. -- Abstract: Since the synthesis of the first ones in 2008, iron-based high temperature superconductors have been the subject of many studies. This great interest is partly due to their higher, upper magnetic field, smaller Fermi surface around the Γ point, and a larger coherence length. This work is focused on A x Fe 2 Se 2 structural superconductor (FeSe, 11 hierarchy; A = K, Cs) as recently observed. ARPES data show novel, electronic structure and a hole-free Fermi surface which is different from previously observed Fermi surface images. We use ab initio density functional theory method to simulate the electronic structure of the novel superconductor A x Fe 2 Se 2 . We compare this electronic structure with those of other Fe-based superconductors

Does LEAP change the screening paradigm for food allergy in infants with eczema?

Science.gov (United States)

Allen, K J; Koplin, J J

2016-01-01

The LEAP randomized controlled trial provides the first direct evidence that delayed introduction of peanut in an infant's diet significantly increases the risk of peanut allergy. However, as often is the case in ground-breaking research, the LEAP study raises almost as many questions as it resolves. Although the quality of design and excellence in study execution is unquestioned, the particular difficulty this study raises is how to generalize results from a trial of high-risk infants, which screened infants for the presence of peanut allergy prior to peanut introduction, to the general population. Although many existing infant feeding guidelines already allow for the introduction of allergenic foods from 4 to 6 months of age irrespective of co-existent risk factors for peanut allergy, these will now need to be revised to more strongly state that avoidance may be harmful. Interim guidelines have already been published which incorporate these recommendations. However, the question as to how to achieve timely introduction of peanut into an infant's diet in a safe and cost-effective way, particularly in high-risk infants, remains unresolved. © 2015 John Wiley & Sons Ltd.

An improved shuffled frog leaping algorithm based evolutionary framework for currency exchange rate prediction

Science.gov (United States)

Dash, Rajashree

2017-11-01

Forecasting purchasing power of one currency with respect to another currency is always an interesting topic in the field of financial time series prediction. Despite the existence of several traditional and computational models for currency exchange rate forecasting, there is always a need for developing simpler and more efficient model, which will produce better prediction capability. In this paper, an evolutionary framework is proposed by using an improved shuffled frog leaping (ISFL) algorithm with a computationally efficient functional link artificial neural network (CEFLANN) for prediction of currency exchange rate. The model is validated by observing the monthly prediction measures obtained for three currency exchange data sets such as USD/CAD, USD/CHF, and USD/JPY accumulated within same period of time. The model performance is also compared with two other evolutionary learning techniques such as Shuffled frog leaping algorithm and Particle Swarm optimization algorithm. Practical analysis of results suggest that, the proposed model developed using the ISFL algorithm with CEFLANN network is a promising predictor model for currency exchange rate prediction compared to other models included in the study.

Results from Super-Kamiokande and K2K

Indian Academy of Sciences (India)

The probability of flavor oscillation (in the simplest, two-component case) is ..... K2K had collected about half of its total planned protons-on-target when the accident at ... [14] Design, construction, and operation of SciFi tracking detector for K2K ...

Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health.

Science.gov (United States)

Maresz, Katarzyna

2015-02-01

Inadequate calcium intake can lead to decreased bone mineral density, which can increase the risk of bone fractures. Supplemental calcium promotes bone mineral density and strength and can prevent osteoporosis. Recent scientific evidence, however, suggests that elevated consumption of calcium supplements may raise the risk for heart disease and can be connected with accelerated deposit of calcium in blood-vessel walls and soft tissues. In contrast, vitamin K2 is associated with the inhibition of arterial calcification and arterial stiffening. An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls. Vitamin K, particularly as vitamin K2, is nearly nonexistent in junk food, with little being consumed even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 could be a means of lowering calcium-associated health risks.

Marcus canonical integral for non-Gaussian processes and its computation: pathwise simulation and tau-leaping algorithm.

Science.gov (United States)

Li, Tiejun; Min, Bin; Wang, Zhiming

2013-03-14

The stochastic integral ensuring the Newton-Leibnitz chain rule is essential in stochastic energetics. Marcus canonical integral has this property and can be understood as the Wong-Zakai type smoothing limit when the driving process is non-Gaussian. However, this important concept seems not well-known for physicists. In this paper, we discuss Marcus integral for non-Gaussian processes and its computation in the context of stochastic energetics. We give a comprehensive introduction to Marcus integral and compare three equivalent definitions in the literature. We introduce the exact pathwise simulation algorithm and give the error analysis. We show how to compute the thermodynamic quantities based on the pathwise simulation algorithm. We highlight the information hidden in the Marcus mapping, which plays the key role in determining thermodynamic quantities. We further propose the tau-leaping algorithm, which advance the process with deterministic time steps when tau-leaping condition is satisfied. The numerical experiments and its efficiency analysis show that it is very promising.

K2-155

DEFF Research Database (Denmark)

Hirano, Teruyuki; Dai, Fei; Livingston, John H.

2018-01-01

We report on the discovery of three transiting super-Earths around K2-155 (EPIC 210897587), a relatively bright early M dwarf (V = 12.81 mag) observed during Campaign 13 of the NASA K2 mission. To characterize the system and validate the planet candidates, we conducted speckle imaging and high......-dispersion optical spectroscopy, including radial velocity measurements. Based on the K2 light curve and the spectroscopic characterization of the host star, the planet sizes and orbital periods are 1.55(-0.17)(+0.20) R-circle plus and 6.34365 +/- 0.00028 days for the inner planet; 1.95(-0.22)(+0.27) R-circle plus...... and 13.85402 +/- 0.00088 days for the middle planet; and 1.64(-0.17)(+0.18) R-circle plus and 40.6835 +/- 0.0031 days for the outer planet. The outer planet (K2-155d) is near the habitable zone, with an insolation 1.67 +/- 0.38 times that of the Earth. The planet's radius falls within the range between...

The Yoneda algebra of a K2 algebra need not be another K2 algebra

OpenAIRE

Cassidy, T.; Phan, C.; Shelton, B.

2010-01-01

The Yoneda algebra of a Koszul algebra or a D-Koszul algebra is Koszul. K2 algebras are a natural generalization of Koszul algebras, and one would hope that the Yoneda algebra of a K2 algebra would be another K2 algebra. We show that this is not necessarily the case by constructing a monomial K2 algebra for which the corresponding Yoneda algebra is not K2.

K2-99

DEFF Research Database (Denmark)

Smith, A. M. S.; Gandolfi, D.; Barragan, O.

2017-01-01

We report the discovery from K2 of a transiting planet in an 18.25-d, eccentric (0.19 +/- 0.04) orbit around K2-99, an 11th magnitude subgiant in Virgo. We confirm the planetary nature of the companion with radial velocities, and determine that the star is a metal-rich ([ Fe/H] = 0.20 +/- 0...

Power cables with extruded insulation and their accessories for rated voltages from 1 kV (Um = 1,2 kV) up to 30 kV (Um = 36 kV) : Part 2: cables for rated voltages from 6 kV (Um = 7,2 kV) up to 30 kV (Um = 36 kV)

CERN Document Server

International Electrotechnical Commission. Geneva

2005-01-01

Power cables with extruded insulation and their accessories for rated voltages from 1 kV (Um = 1,2 kV) up to 30 kV (Um = 36 kV) : Part 2: cables for rated voltages from 6 kV (Um = 7,2 kV) up to 30 kV (Um = 36 kV)

A great leap forward in microbial ecology.

Science.gov (United States)

Okabe, Satoshi; Oshiki, Mamoru; Kamagata, Yoichi; Yamaguchi, Nobuyasu; Toyofuku, Masanori; Yawata, Yutaka; Tashiro, Yosuke; Nomura, Nobuhiko; Ohta, Hiroyuki; Ohkuma, Moriya; Hiraishi, Akira; Minamisawa, Kiwamu

2010-01-01

Ribosomal RNA (rRNA) sequence-based molecular techniques emerged in the late 1980s, which completely changed our general view of microbial life. Coincidentally, the Japanese Society of Microbial Ecology (JSME) was founded, and its official journal "Microbes and Environments (M&E)" was launched, in 1985. Thus, the past 25 years have been an exciting and fruitful period for M&E readers and microbiologists as demonstrated by the numerous excellent papers published in M&E. In this minireview, recent progress made in microbial ecology and related fields is summarized, with a special emphasis on 8 landmark areas; the cultivation of uncultured microbes, in situ methods for the assessment of microorganisms and their activities, biofilms, plant microbiology, chemolithotrophic bacteria in early volcanic environments, symbionts of animals and their ecology, wastewater treatment microbiology, and the biodegradation of hazardous organic compounds.

When climate twitches, evolution takes great leaps

International Nuclear Information System (INIS)

Kerr, R.A.

1992-01-01

Earth's climate system has ridden a slow roller coaster for the past 60 million years. It warmed gradually until about 53 million years ago, reaching a peak that brought crocodiles to northern Canada; then it entered a long, undulating downgrade toward the ice-age world of the past few million years. Because the same span of time brought major evolutionary changes, including the rise of modern mammals, paleontologists have long assumed that these slow temperature changes helped spur the processes of evolution. But recent findings have suggested that another, more potent mechanisms was also at work: Abrupt climate excursions, superimposed on these long-term trends, have now been linked to rapid periods of mammal evolution. The evidence for short, sharp evolutionary shocks comes from studies of a pair of mirror-image climate shifts at opposite ends of the Eocene epoch, 55 million and 33.5 million years ago. In both cases, researchers studying the record of climate preserved in sea-floor sediments have found that a gradual climate change-warming in the first case, cooling in the second - suddenly steepened into a short-lived pulse of extreme warming or cooling. The short time scale of these events and their clear coincidence with turning points in the evolution of mammals are providing the tightest links yet between global climate change and evolution on land

K2 and K2*: efficient alignment-free sequence similarity measurement based on Kendall statistics.

Science.gov (United States)

Lin, Jie; Adjeroh, Donald A; Jiang, Bing-Hua; Jiang, Yue

2018-05-15

Alignment-free sequence comparison methods can compute the pairwise similarity between a huge number of sequences much faster than sequence-alignment based methods. We propose a new non-parametric alignment-free sequence comparison method, called K2, based on the Kendall statistics. Comparing to the other state-of-the-art alignment-free comparison methods, K2 demonstrates competitive performance in generating the phylogenetic tree, in evaluating functionally related regulatory sequences, and in computing the edit distance (similarity/dissimilarity) between sequences. Furthermore, the K2 approach is much faster than the other methods. An improved method, K2*, is also proposed, which is able to determine the appropriate algorithmic parameter (length) automatically, without first considering different values. Comparative analysis with the state-of-the-art alignment-free sequence similarity methods demonstrates the superiority of the proposed approaches, especially with increasing sequence length, or increasing dataset sizes. The K2 and K2* approaches are implemented in the R language as a package and is freely available for open access (http://community.wvu.edu/daadjeroh/projects/K2/K2_1.0.tar.gz). yueljiang@163.com. Supplementary data are available at Bioinformatics online.

LAMI: A gesturally controlled three-dimensional stage Leap (Motion-based) Audio Mixing Interface

OpenAIRE

Wakefield, Jonathan P.; Dewey, Christopher; Gale, William

2017-01-01

Interface designers are increasingly exploring alternative approaches to user input/control. LAMI is a Leap (Motion-based) AMI which takes user’s hand gestures and maps these to a three-dimensional stage displayed on a computer monitor. Audio channels are visualised as spheres whose Y coordinate is spectral centroid and X and Z coordinates are controlled by hand position and represent pan and level respectively. Auxiliary send levels are controlled via wrist rotation and vertical hand positio...

Examples of Small-scale Urban Area. Experiment Energy Leap Built Environment; Voorbeeldenboek Kleinschalige Binnenstedelijke Gebieden. Experiment Energiesprong Gebouwde Omgeving

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-03-15

The Dutch government considers the transition process to be necessary and stimulates investments in energy innovations in the built environment. This innovation effort is the programme 'Energy Leap' (Energiesprong), which is being carried out by the Steering Group Experimental Housing (SEV) on behalf of the Dutch Ministry of the Interior and Kingdom Relations (BZK). The programme is derived from the Innovation Agenda for Energy in the Built Environment. The examples in this book are intended to inspire (potential) participants in the Experiment Energy Leap for Small-scale Urban Areas. The examples focus explicitly on the reduction of CO2 emissions in urban areas, and thus, in addition to CO2 reduction on a building level, the aspects of energy supply, (local) energy production and the energy infrastructure [Dutch] Het SEV-programma Energiesprong (SEV is Stuurgroep Experimenten Volkshuisvesting) beoogt een substantiele bijdrage te leveren aan de condities waaronder de energietransitie effectief tot stand kan komen. In dit basisplan wordt uiteengezet hoe de markt daartoe moet kunnen komen en welke activiteiten daarvoor worden ondersteund, opgezet en/of uitgevoerd vanuit Energiesprong. Het SEV-programma Energiesprong wordt in opdracht van het Ministerie van Binnenlandse Zaken en Koninkrijksrelaties (BZK) uitgevoerd. Het programma is afgeleid van de Innovatie Agenda energie Gebouwde Omgeving. Dit voorbeeldenboek dient ter inspiratie van (potentiele) deelnemers aan het Experiment Energiesprong kleinschalige Binnenstedelijke Gebieden. De voorbeelden richten zich expliciet op de CO2-reductie van binnenstedelijke gebieden en daarmee, naast de CO2-reductie op woning- en gebouwniveau, op de aspecten energievoorziening, (locale) energieopwekking en energie-infrastructuur.

Minimum K_2,3-saturated Graphs

OpenAIRE

Chen, Ya-Chen

2010-01-01

A graph is K_{2,3}-saturated if it has no subgraph isomorphic to K_{2,3}, but does contain a K_{2,3} after the addition of any new edge. We prove that the minimum number of edges in a K_{2,3}-saturated graph on n >= 5 vertices is sat(n, K_{2,3}) = 2n - 3.

Shuffled Frog Leaping Algorithm for Preemptive Project Scheduling Problems with Resource Vacations Based on Patterson Set

Directory of Open Access Journals (Sweden)

Yi Han

2013-01-01

Full Text Available This paper presents a shuffled frog leaping algorithm (SFLA for the single-mode resource-constrained project scheduling problem where activities can be divided into equant units and interrupted during processing. Each activity consumes 0–3 types of resources which are renewable and temporarily not available due to resource vacations in each period. The presence of scarce resources and precedence relations between activities makes project scheduling a difficult and important task in project management. A recent popular metaheuristic shuffled frog leaping algorithm, which is enlightened by the predatory habit of frog group in a small pond, is adopted to investigate the project makespan improvement on Patterson benchmark sets which is composed of different small and medium size projects. Computational results demonstrate the effectiveness and efficiency of SFLA in reducing project makespan and minimizing activity splitting number within an average CPU runtime, 0.521 second. This paper exposes all the scheduling sequences for each project and shows that of the 23 best known solutions have been improved.

INTRINSIC SHAPE OF STAR-FORMING BzK GALAXIES AT z ∼ 2 IN GOODS-N

International Nuclear Information System (INIS)

Yuma, Suraphong; Ohta, Kouji; Yabe, Kiyoto; Kajisawa, Masaru; Ichikawa, Takashi

2011-01-01

We study the structure of star-forming galaxies at z ∼ 2 in a Great Observatories Origins Deep Survey North field selected as star-forming BzK (sBzK) galaxies down to K AB B > C, we find that the mean B/A ratio is 0.61 +0.05 -0.08 and disk thickness C/A is 0.28 +0.03 -0.04 . This indicates that the single-component sBzK galaxies at z ∼ 2 have a bar-like or oval shape rather than a round disk shape. The shape seems to resemble a bar/oval structure that forms through bar instability; if this is the case, the intrinsic shape may give us a clue to understand dynamical evolution of baryonic matter in a dark matter halo.

Measurements by A LEAP-Based Virtual Glove for the Hand Rehabilitation

Directory of Open Access Journals (Sweden)

Giuseppe Placidi

2018-03-01

Full Text Available Hand rehabilitation is fundamental after stroke or surgery. Traditional rehabilitation requires a therapist and implies high costs, stress for the patient, and subjective evaluation of the therapy effectiveness. Alternative approaches, based on mechanical and tracking-based gloves, can be really effective when used in virtual reality (VR environments. Mechanical devices are often expensive, cumbersome, patient specific and hand specific, while tracking-based devices are not affected by these limitations but, especially if based on a single tracking sensor, could suffer from occlusions. In this paper, the implementation of a multi-sensors approach, the Virtual Glove (VG, based on the simultaneous use of two orthogonal LEAP motion controllers, is described. The VG is calibrated and static positioning measurements are compared with those collected with an accurate spatial positioning system. The positioning error is lower than 6 mm in a cylindrical region of interest of radius 10 cm and height 21 cm. Real-time hand tracking measurements are also performed, analysed and reported. Hand tracking measurements show that VG operated in real-time (60 fps, reduced occlusions, and managed two LEAP sensors correctly, without any temporal and spatial discontinuity when skipping from one sensor to the other. A video demonstrating the good performance of VG is also collected and presented in the Supplementary Materials. Results are promising but further work must be done to allow the calculation of the forces exerted by each finger when constrained by mechanical tools (e.g., peg-boards and for reducing occlusions when grasping these tools. Although the VG is proposed for rehabilitation purposes, it could also be used for tele-operation of tools and robots, and for other VR applications.

Measurements by A LEAP-Based Virtual Glove for the Hand Rehabilitation.

Science.gov (United States)

Placidi, Giuseppe; Cinque, Luigi; Polsinelli, Matteo; Spezialetti, Matteo

2018-03-10

Hand rehabilitation is fundamental after stroke or surgery. Traditional rehabilitation requires a therapist and implies high costs, stress for the patient, and subjective evaluation of the therapy effectiveness. Alternative approaches, based on mechanical and tracking-based gloves, can be really effective when used in virtual reality (VR) environments. Mechanical devices are often expensive, cumbersome, patient specific and hand specific, while tracking-based devices are not affected by these limitations but, especially if based on a single tracking sensor, could suffer from occlusions. In this paper, the implementation of a multi-sensors approach, the Virtual Glove (VG), based on the simultaneous use of two orthogonal LEAP motion controllers, is described. The VG is calibrated and static positioning measurements are compared with those collected with an accurate spatial positioning system. The positioning error is lower than 6 mm in a cylindrical region of interest of radius 10 cm and height 21 cm. Real-time hand tracking measurements are also performed, analysed and reported. Hand tracking measurements show that VG operated in real-time (60 fps), reduced occlusions, and managed two LEAP sensors correctly, without any temporal and spatial discontinuity when skipping from one sensor to the other. A video demonstrating the good performance of VG is also collected and presented in the Supplementary Materials. Results are promising but further work must be done to allow the calculation of the forces exerted by each finger when constrained by mechanical tools (e.g., peg-boards) and for reducing occlusions when grasping these tools. Although the VG is proposed for rehabilitation purposes, it could also be used for tele-operation of tools and robots, and for other VR applications.

Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines.

Science.gov (United States)

Okayasu, H; Ishihara, M; Satoh, K; Sakagami, H

2001-01-01

Vitamin K1, K2 and K3 were compared for their cytotoxic activity, radical generation and O2- scavenging activity. Among these compounds, vitamin K3 showed the highest cytotoxic activity against human oral tumor cell lines (HSC-2, HSG), human promyelocytic leukemic cell line (HL-60) and human gingival fibroblast (HGF). Vitamin K3 induced internucleosomal DNA fragmentation in HL-60 cells, but not in HSC-2 or HSG cells. The cytotoxic activity of vitamins K2 and K1 was one and two orders lower, respectively, than K3. Vitamin K2, but not vitamin K3, showed tumor-specific cytotoxic action. ESR spectroscopy showed that only vitamin K3 produced radical(s) under alkaline condition and most potently enhanced the radical intensity of sodium ascorbate and scavenged O2- (generated by hypoxanthine-xanthine oxidase reaction system); vitamin K2 was much less active whereas vitamin K1 was inactive. These data suggest that the cytotoxic activity of vitamin K3 is generated by radical-mediated oxidation mechanism and that this vitamin has two opposing actions (that is, antioxidant and prooxidant), depending on the experimental conditions.

Comparative mapping of DNA probes derived from the V{sub k} immunoglobulin gene regions on human and great ape chromosomes by fluorescence in situ hybridization

Energy Technology Data Exchange (ETDEWEB)

Arnold, N.; Wienberg, J.; Ermert, K. [Universitaet Muenchen (Germany)] [and others

1995-03-01

Fluorescence in situ hybridization (FISH) of cosmid clones of human V{sub K} gene regions to human and primate chromosomes contributed to the dating of chromosome reorganizations in evolution. A clone from the K locus at 2p11-p12 (cos 106) hybridized to the assumed homologous chromosome bands in the chimpanzees Pan troglodytes (PTR) and P. paniscus (PPA), the Gorilla gorilla (GGO), and the orangutan Pongo Pygmaeus (PPY). Human and both chimpanzees differed from gorilla and orangutan by the mapping of cos 170, a clone derived from chromosome 2cen-q11.2; the transposition of this orphon to the other side of the centromere can, therefore, be dated after the human/chimpanzee and gorilla divergence. Hybridization to homologous bands was also found with a cosmid clone containing a V{sub K}I orphon located on chromosome 1 (cos 115, main signal at 1q31-q32), although the probe is not fully unique. Also, a clone derived from the orphon V{sub K} region on chromosome 22q11 (cos 121) hybridized to the homologous bands in the great apes. This indicates that the orphons on human chromosomes 1 and 22 had been translocated early in primate evolution. 18 refs., 2 figs.

Flux-coherent series SQUID array magnetometers operating above 77 K with superior white flux noise than single-SQUIDs at 4.2 K

Science.gov (United States)

Chesca, Boris; John, Daniel; Mellor, Christopher J.

2015-10-01

A very promising direction to improve the sensitivity of magnetometers based on superconducting quantum interference devices (SQUIDs) is to build a series-array of N non-interacting SQUIDs operating flux-coherently, because in this case their voltage modulation depth, ΔV, linearly scales with N whereas the white flux noise SΦ1/2 decreases as 1/N1/2. Here, we report the realization of both these improvements in an advanced layout of very large SQUID arrays made of YBa2Cu3O7. Specially designed with large area narrow flux focusers for increased field sensitivity and improved flux-coherency, our arrays have extremely low values for SΦ1/2 between (0.25 and 0.44) μΦ0/Hz1/2 for temperatures in the range (77-83) K. In this respect, they outperform niobium/aluminium trilayer technology-based single-SQUIDs operating at 4.2 K. Moreover, with values for ΔV and transimpedance in the range of (10-17) mV and (0.3-2.5) kΩ, respectively, a direct connection to a low-noise room temperature amplifier is allowed, while matching for such readout is simplified and the available bandwidth is greatly increased. These landmark performances suggest such series SQUID arrays are ideal candidates to replace single-SQUIDs operating at 4.2 K in many applications.

Detection and characterization of pXFSL21, a novel single-copy plasmid from Xylella fastidiosa Strain Stag’s Leap

Science.gov (United States)

Xylella fastidiosa Strain Stag’s Leap, originally isolated from Napa Valley, California, is highly virulent in causing Pierce’s Disease (PD) of grapevine. Plasmids are extrachromosomal genetic elements associated with bacterial environmental adaptation such as virulence development. In this study, t...

LEAP: A randomized-controlled trial of a lay-educator inpatient asthma education program.

Science.gov (United States)

Rice, Jessica L; Matlack, Kristen M; Simmons, Marsha D; Steinfeld, Jonathan; Laws, Margaret A; Dovey, Mark E; Cohen, Robyn T

2015-06-29

To evaluate the impact of LEAP, a volunteer-based, inpatient asthma education program for families of inner-city children with asthma. 711 children ages 2-17 years admitted with status asthmaticus were randomized to receive usual care or usual care plus a supplemental education intervention. Both groups completed a baseline interview. Trained volunteer lay educators conducted individualized bedside education with the intervention group. Primary outcome was attendance at a post-hospitalization follow-up visit 7-10 days after discharge. Secondary outcomes included parent-reported asthma management behaviors, symptoms, and self-efficacy scores from a one month follow-up interview. Post-hospitalization asthma clinic attendance was poor (38%), with no difference between groups. Families randomized to the intervention group were more likely to report use of a controller (OR 2.4, 95% CI 1.3-4.2, peducation by trained lay volunteers was associated with improved asthma management behaviors. This novel volunteer-based program could have widespread implications as a sustainable model for asthma education. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

LEAP: local environmental action plan. Municipality of Lipkovo

International Nuclear Information System (INIS)

2004-01-01

This document comprises all geo-environmental problems with adverse on the quality of the overall environment. Based on this, the document contains many scientific and expert statements and facts supported by data, diagrams maps, etc. At the same time, taking into consideration the problems appearing on the territory of Lipkovo Municipality, the environmental problems are by their priority presented as issues of first, second and third degree, requiring most urgent settlement through the leap document for the Municipality of Lipkovo. This is followed by the presentation of priorities and the strategy for elimination of degradation processes and establishment of environmental balance in the space. According to the current data, it seems that this Municipality is faced with numerous environmental problems, beginning with air pollution, water contamination, solid waste disposal, the landfill of the abandoned mine Lojane and the site around the Railroad Station at Tabanovci, supply of drinking water, destruction of forests, expansion of rural settlements over cultivable lands, the issue of space urbanization, unemployment, etc

Phase formation in K2O(K2CO3)-CdO-MoO3 system

International Nuclear Information System (INIS)

Tsirenova, G.D.; Tsybikova, B.A.; Bazarova, Zh.G.; Solodovnikov, S.F.; Zolotova, E.S.

2000-01-01

Phase formation in K 2 O(K 2 CO 3 )-CdO-MoO 3 system are studied by the methods of x-ray diffraction, thermal and crystal optical analyses. Three potassium-cadmium molybdates are detected: K 4 Cd(MoO 4 ) 3 with a new structure, alluodite-like K 4-2x Cd 1+x (MoO 4 ) 3 (0.26≤x≤0.38 at 470 Deg C) and K 4 CdMo 4 O 15 of K 4 MnMo 4 O 15 type. First of them decomposes in solid phase at 580 Deg C, and others melt incongruently at 720 and 515 Deg C correspondingly. It is established that K 4-2x Cd 1+x (MoO 4 ) 3 compound undergoes phase transition of the second type in the temperature interval of 500-550 Deg C. Phase diagram of quasibinary cross section K 2 MoO 4 -CdMoO 4 is plotted [ru

Long-term scenario alternatives and their implications: LEAP model application of Panama's electricity sector

International Nuclear Information System (INIS)

McPherson, Madeleine; Karney, Bryan

2014-01-01

Panama recently enacted a new law, which aims to promote wind energy by mandating long term power purchase tenders. The implications of this new law lend some uncertainty to Panama's electricity development pathway. This paper quantitatively analyzes the current status of power generation in Panama, and explores various potential future scenarios and the associated impacts on the system marginal cost, global warming potential, and resource diversity index. To this end, this study applies the scenario development methodology developed by Schwartz in the context of the energy-economic modeling platform ‘Long-range Energy Alternative Planning’ (LEAP). Four scenarios are developed and analyzed. The Business as Usual scenario extrapolates the electricity generation trend that has been observed over the last decade; it is compared to three alternative scenarios which have more specific objectives. Scenario 1 encourages climate mitigation without incorporating new technologies in the generation mix, Scenario 2 maximizes resource diversity, and Scenario 3 minimizes global warming potential. For each scenario, the composition of the electricity generation profile, system marginal cost, global warming potential, and resource diversity is predicted quantitatively. These scenarios to not attempt to forecast likely developments, but rather illuminate the tradeoffs that different development pathways entail. - Highlights: • This paper models Panama's electricity sector using the LEAP model platform. • Four scenarios are developed and analyzed. • Impact analysis includes: system cost, global warming potential, resource diversity index. • Panama can achieve a sustainable grid with existing technologies and costs. • There is an tradeoff between the resource diversity and global warming potential

Evaluation of optimal dual axis concentrated photovoltaic thermal system with active ventilation using Frog Leap algorithm

International Nuclear Information System (INIS)

Gholami, H.; Sarwat, A.I.; Hosseinian, H.; Khalilnejad, A.

2015-01-01

Highlights: • Electro-thermal performance of open-loop controlled dual axis CPVT is investigated. • For using the absorbed heat, active ventilation with a heat storage tank is used. • Economic optimization of the system is performed, using Frog Leap algorithm. • Detailed model of all sections is simulated with their characteristics evaluation. • Triple-junction photovoltaic cells, which are the most recent technology, are used. - Abstract: In this study, design and optimization of a concentrated photovoltaic thermal (CPVT) system considering electrical, mechanical, and economical aspects is investigated. For this purpose, each section of the system is simulated in MATLAB, in detail. Triple-junction photovoltaic cells, which are the most recent technology, are used in this study. They are more efficient in comparison to conventional photovoltaic cells. Unlike ordinary procedures, in this work active ventilation is used for absorbing the thermal power of radiation, using heat storage tanks, which not only results in increasing the electrical efficiency of the system through decreasing the temperature, but also leads to storing and managing produced thermal energy and increasing the total efficiency of the system up to 85 percent. The operation of the CPVT system is investigated for total hours of the year, considering the needed thermal load, meteorological conditions, and hourly radiation of Khuznin, a city in Qazvin province, Iran. Finally, the collector used for this system is optimized economically, using frog leap algorithm, which resulted in the cost of 13.4 $/m"2 for a collector with the optimal distance between tubes of 6.34 cm.

K2V2O2(AsO42

Directory of Open Access Journals (Sweden)

Thierry Roisnel

2012-07-01

Full Text Available The vanadium oxide arsenate with formula K2V2O2(AsO42, dipotassium divanadium(IV dioxide diarsenate, has been synthesized by solid-state reaction in an evacuated silica ampoule. Its structure is isotypic with K2V2O2(PO42. The framework is built up from corner-sharing VO6 octahedra and AsO4 tetrahedra, creating an infinite [VAsO8]∞ chain running along the a- and c-axis directions. The K+ cations are located in hexagonal tunnels, which are delimited by the connection of the [VAsO8]∞ chains.

Y2K UPDATE

CERN Multimedia

Sverre JARP

1999-01-01

Concerning Y2K preparation, please note the following:Everybody, who has a NICE installation on his/her PC, needs to log in to NICE at least once before Xmas to get the Y2K update installed. This applies especially to dual boot systems.The test schedule on Y2Kplus.cern.ch will be prolonged. The last restart took place on 10 November and two more will take place on 24 November and 8 December, respectively. The Oracle users responsible for the maintenance of Oracle Forms applications which include PL/SQL blocks where date fields are handled with the default format are requested to contact oracle.support@cern.ch at their earliest convenience.Sverre Jarp (CERN Y2K co-ordinator, phone: 74944)

Estimation of radiative parameters in participating media using shuffled frog leaping algorithm

Directory of Open Access Journals (Sweden)

Ren Ya-Tao

2017-01-01

Full Text Available The transient radiative transfer in 1-D homogeneous media with ultra-short Gaussian pulse laser irradiated was investigation by the finite volume method. The concept of optimal detection distance was proposed. The radiation characteristic was studied thoroughly. Afterwards, a memetic meta-heuristic shuffled frog leaping algorithm was introduced to inverse transient radiative problems. It is demonstrated that the extinction coefficient and scattering albedo can be retrieved accurately even with noisy data in a homogeneous absorbing and isotropic scattering plane-parallel slab. Finally, a technique was proposed to accelerate the inverse process by reducing the searching space of the radiative parameters.

Effects of NH4+, K+, Mg2+, and Ca2+ on the Cesium Adsorption/Desorption in Binding Sites of Vermiculitized Biotite.

Science.gov (United States)

Yin, Xiangbiao; Wang, Xinpeng; Wu, Hao; Takahashi, Hideharu; Inaba, Yusuke; Ohnuki, Toshihiko; Takeshita, Kenji

2017-12-05

The reversibility of cesium adsorption in contaminated soil is largely dependent on its interaction with micaceous minerals, which may be greatly influenced by various cations. Herein, we systematically investigated the effects of NH 4 + , K + , Mg 2+ , and Ca 2+ on the adsorption/desorption of Cs + into different binding sites of vermiculitized biotite (VB). Original VB was initially saturated by NH 4 + , K + , or Mg 2+ ; we then evaluated the adsorption of Cs + on three treated VBs, and the desorption by extraction with NH 4 + , K + , Mg 2+ , or Ca 2+ was further evaluated. Our structural analysis and Cs + extractability determinations showed that NH 4 + and K + both collapsed the interlayers of VB, resulting in the dominant adsorption of Cs + to external surface sites on which Cs + was readily extracted by NH 4 + , K + , Mg 2+ , or Ca 2+ irrespective of their species, whereas Mg 2+ maintained the VB with expanded interlayers, leading to the overwhelming adsorption of Cs + in collapsed interlayer sites on which the Cs + desorption was difficult and varied significantly by the cations used in extraction. The order of Cs + extraction ability from the collapsed interlayers was K + ≫ Mg 2+ ≈ Ca 2+ ≫ NH 4 + . These results could provide important insights into Cs migration in soil and its decontamination for soil remediation.

Neutrino Oscillation Experiments with J-PARC: T2K, T2K-II and Hyper-Kamiokande

CERN Multimedia

CERN. Geneva

2016-01-01

The T2K experiment started the operation in 2010, and advances neutrino physics with the discovery of electron neutrino appearance in the muon neutrino beam and precision measurements of neutrino oscillation parameters. In 2016, the measurements of anti-neutrino oscillation directly constrain CP violation in neutrino oscillation. In this colloquium, we introduce many physics results from T2K including the most recent one of the CP violation. By utilizing the J-PARC neutrino beam, the upgrade of the T2K experiment (naming T2K-II) is planned and Hyper-Kamiokande is proposed to explore neutrino physics further. In T2K-II, the beam power of J-PARC will be upgraded to 1.3 MW around 2020. Hyper-Kamiokande is the larger Water Cherenkov detector of 520 k...

Wind-powered wheel locomotion, initiated by leaping somersaults, in larvae of the southeastern beach tiger beetle (Cicindela dorsalis media.

Directory of Open Access Journals (Sweden)

Alan Harvey

2011-03-01

Full Text Available Rapid movement is challenging for elongate, soft-bodied animals with short or no legs. Leaping is known for only a few animals with this "worm-like" morphology. Wheel locomotion, in which the animal's entire body rolls forward along a central axis, has been reported for only a handful of animals worldwide. Here we present the first documented case of wind-powered wheel locomotion, in larvae of the coastal tiger beetle Cicindela dorsalis media. When removed from their shallow burrows, larvae easily can be induced to enter a behavioral sequence that starts with leaping; while airborne, larvae loop their body into a rotating wheel and usually either "hit the ground rolling" or leap again. The direction larvae wheel is closely related to the direction in which winds are blowing; thus, all our larvae wheeled up-slope, as winds at our study site consistently blew from sea to land. Stronger winds increased both the proportion of larvae wheeling, and the distance traveled, exceeding 60 m in some cases. In addition, the proportion of larvae that wheel and the distance traveled by wheeling larvae are significantly greater on smooth sandy beaches than on beach surfaces made rough and irregular by pedestrian, equestrian, and vehicular traffic. Like other coastal species of tiger beetles, C. dorsalis media has suffered major declines in recent years that are clearly correlated with increased human impacts. The present study suggests that the negative effects of beach traffic may be indirect, preventing larvae from escaping from predators using wheel locomotion by disrupting the flat, hard surface necessary for efficient wheeling.

The 1964 Great Alaska Earthquake and tsunamis: a modern perspective and enduring legacies

Science.gov (United States)

Brocher, Thomas M.; Filson, John R.; Fuis, Gary S.; Haeussler, Peter J.; Holzer, Thomas L.; Plafker, George; Blair, J. Luke

2014-01-01

The magnitude 9.2 Great Alaska Earthquake that struck south-central Alaska at 5:36 p.m. on Friday, March 27, 1964, is the largest recorded earthquake in U.S. history and the second-largest earthquake recorded with modern instruments. The earthquake was felt throughout most of mainland Alaska, as far west as Dutch Harbor in the Aleutian Islands some 480 miles away, and at Seattle, Washington, more than 1,200 miles to the southeast of the fault rupture, where the Space Needle swayed perceptibly. The earthquake caused rivers, lakes, and other waterways to slosh as far away as the coasts of Texas and Louisiana. Water-level recorders in 47 states—the entire Nation except for Connecticut, Delaware, and Rhode Island— registered the earthquake. It was so large that it caused the entire Earth to ring like a bell: vibrations that were among the first of their kind ever recorded by modern instruments. The Great Alaska Earthquake spawned thousands of lesser aftershocks and hundreds of damaging landslides, submarine slumps, and other ground failures. Alaska’s largest city, Anchorage, located west of the fault rupture, sustained heavy property damage. Tsunamis produced by the earthquake resulted in deaths and damage as far away as Oregon and California. Altogether the earthquake and subsequent tsunamis caused 129 fatalities and an estimated $2.3 billion in property losses (in 2013 dollars). Most of the population of Alaska and its major transportation routes, ports, and infrastructure lie near the eastern segment of the Aleutian Trench that ruptured in the 1964 earthquake. Although the Great Alaska Earthquake was tragic because of the loss of life and property, it provided a wealth of data about subductionzone earthquakes and the hazards they pose. The leap in scientific understanding that followed the 1964 earthquake has led to major breakthroughs in earth science research worldwide over the past half century. This fact sheet commemorates Great Alaska Earthquake and

Terapia baseada em realidade virtual usando o leap motion controller para reabilitação do membro superior após acidente vascular cerebral = Virtual reality therapy using the leap motion controller for post-stroke upper limb rehabilitation Virtual reality therapy using the Leap Motion Controller for post-stroke upper limb rehabilitation

Directory of Open Access Journals (Sweden)

Soares, Nayron Medeiros

2017-01-01

Full Text Available OBJETIVOS: Avaliar a aplicabilidade de um sensor de movimento, baseado em realidade virtual, para promover a reabilitação do membro superior após um acidente vascular cerebral. RELATO DOS CASOS: Três pacientes após acidente vascular cerebral realizaram um treino para reabilitação do membro superior com realidade virtual usando a tecnologia Leap Motion Controller e o jogo Playground 3D®, durante três dias consecutivos. No primeiro e no terceiro dia, foram avaliados com os testes Caixa e Blocos, Coordenação Óculo-Manual de Melo e Estimulação Magnética Transcraniana. No último dia, foram aplicadas Fichas de Avaliação da Experiência do paciente. Após o treinamento proposto, observou-se diminuição do limiar motor em ambos os hemisférios cerebrais e melhores desempenhos nos testes que avaliaram a habilidade manual e óculo-manual. A terapia proposta foi bem recebida pelos pacientes testados. CONCLUSÕES: Não foram observados efeitos adversos e os resultados mostram-se promissores e precisos no treinamento realizado com realidade virtual usando a tecnologia Leap Motion Controller e o jogo Playground 3D®. O treinamento proporcionou uma participação ativa dos pacientes na reabilitação das sequelas de extremidade superior após um acidente vascular cerebral

[Excitation transfer between high-lying states in K2 in collisions with ground state K and H2 molecules].

Science.gov (United States)

Shen, Xiao-Yan; Liu, Jing; Dai, Kang; Shen, Yi-Fan

2010-02-01

Pure potassium vapor or K-H2 mixture was irradiated in a glass fluorescence cell with pulses of 710 nm radiation from an OPO laser, populating K2 (1lambda(g)) state by two-photon absorption. Cross sections for 1lambda(g)-3lambda(g) transfer in K2 were determined using methods of molecular fluorescence. During the experiments with pure K vapor, the cell temperature was varied between 553 and 603 K. The K number density was determined spectroscopically by the white-light absorption measurement in the blue wing of the self-broadened resonance D2 line. The resulting fluorescence included a direct component emitted in the decay of the optically excitation and a sensitized component arising from the collisionally populated state. The decay signal of time-resolved fluorescence from1lambda(g) -->1 1sigma(u)+ transition was monitored. It was seen that just after the laser pulse the fluorescence of the photoexcited level decreased exponentially. The effective lifetimes of the 1lambda(g) state can be resolved. The plot of reciprocal of effective lifetimes of the 1lambda(g) state against K densities yielded the slope that indicated the total cross section for deactivation and the intercept that provided the radiative lifetime of the state. The radiative lifetime (20 +/- 2) ns was obtained. The cross section for deactivation of the K2(1lambda(g)) molecules by collisions with K is (2.5 +/- 0.3) x 10(-14) cm2. The time-resolved intensities of the K23lambda(g) --> 1 3sigma(u)+ (484 nm) line were measured. The radiative lifetime (16.0 +/- 3.2) ns and the total cross section (2.5 +/- 0.6) x 10(-14) cm2 for deactivation of the K2 (3lambda(g)) state can also be determined through the analogous procedure. The time-integrated intensities of 1lambda(g) --> 1 1sigma(u)+ and 3lambda(g) --> 1 3sigma(u)+ transitions were measured. The cross section (1.1 +/- 0.3) x10(-14) cm2 was obtained for K2 (1lambda(g))+ K --> K2 (3lambda(g)) + K collisions. During the experiments with K-H2 mixture, the

Rate constant and thermochemistry for K + O2 + N2 = KO2 + N2

DEFF Research Database (Denmark)

Sorvajärvi, Tapio; Viljanen, Jan; Toivonen, Juha

2015-01-01

in the form of double exponential decays of [K], which yielded both kR1 and the equilibrium constant for KO2 formation. kR1 can be summarized as 1.07 × 10-30(T/1000 K)-0.733 cm6 molecule-2 s-1. Combination with literature values leads to a recommended kR1 of 5.5 × 10-26T-1.55 exp(-10/T) cm6 molecule-2 s-1...... over 250-1320 K, with an error limit of a factor of 1.5. A vant Hoff analysis constrained to fit the computed ΔS298 yields a K-O2 bond dissociation enthalpy of 184.2 ± 4.0 kJ mol-1 at 298 K and ΔfH298(KO2) = -95.2 ± 4.1 kJ mol-1. The corresponding D0 is 181.5 ± 4.0 kJ mol-1. This value compares well...

An Improved Transit Measurement for a 2.4 R ⊕ Planet Orbiting A Bright Mid-M Dwarf K2–28

Science.gov (United States)

Chen, Ge; Knutson, Heather A.; Dressing, Courtney D.; Morley, Caroline V.; Werner, Michael; Gorjian, Varoujan; Beichman, Charles; Benneke, Björn; Christiansen, Jessie L.; Ciardi, David; Crossfield, Ian; Howell, Steve B.; Krick, Jessica E.; Livingston, John; Morales, Farisa Y.; Schlieder, Joshua E.

2018-05-01

We present a new Spitzer transit observation of K2–28b, a sub-Neptune (R p = 2.45 ± 0.28 R ⊕) orbiting a relatively bright (V mag = 16.06, K mag = 10.75) metal-rich M4 dwarf (EPIC 206318379). This star is one of only seven with masses less than 0.2 {M}ȯ known to host transiting planets, and the planet appears to be a slightly smaller analogue of GJ 1214b (2.85+/- 0.20 {R}\\oplus ). Our new Spitzer observations were taken two years after the original K2 discovery data and have a significantly higher cadence, allowing us to derive improved estimates for this planet’s radius, semimajor axis, and orbital period, which greatly reduce the uncertainty in the prediction of near future transit times for the James Webb Space Telescope (JWST) observations. We also evaluate the system’s suitability for atmospheric characterization with JWST and find that it is currently the only small (K2–28b to be representative of the kind of mid-M systems that should be detectable in the TESS sample.

Flux-coherent series SQUID array magnetometers operating above 77 K with superior white flux noise than single-SQUIDs at 4.2 K

International Nuclear Information System (INIS)

Chesca, Boris; John, Daniel; Mellor, Christopher J.

2015-01-01

A very promising direction to improve the sensitivity of magnetometers based on superconducting quantum interference devices (SQUIDs) is to build a series-array of N non-interacting SQUIDs operating flux-coherently, because in this case their voltage modulation depth, ΔV, linearly scales with N whereas the white flux noise S Φ 1/2 decreases as 1/N 1/2 . Here, we report the realization of both these improvements in an advanced layout of very large SQUID arrays made of YBa 2 Cu 3 O 7 . Specially designed with large area narrow flux focusers for increased field sensitivity and improved flux-coherency, our arrays have extremely low values for S Φ 1/2 between (0.25 and 0.44) μΦ 0 /Hz 1/2 for temperatures in the range (77–83) K. In this respect, they outperform niobium/aluminium trilayer technology-based single-SQUIDs operating at 4.2 K. Moreover, with values for ΔV and transimpedance in the range of (10–17) mV and (0.3–2.5) kΩ, respectively, a direct connection to a low-noise room temperature amplifier is allowed, while matching for such readout is simplified and the available bandwidth is greatly increased. These landmark performances suggest such series SQUID arrays are ideal candidates to replace single-SQUIDs operating at 4.2 K in many applications

Potassium Capture by Kaolin, Part 2: K2CO3, KCI, and K2SO4

DEFF Research Database (Denmark)

Wang, Guoliang; Jensen, Peter Arendt; Wu, Hao

2018-01-01

residence time on the reaction was investigated. The results showed that the K-capture level (C-K) (g potassium reacted by per g kaolin available) of K2CO3 and KCI by kaolin generally followed the equilibrium predictions at temperatures above 1100 degrees C, when using a kaolin particle size of D50 = 5.......47 mu m and a residence time of 1.2 s. This revealed that a nearly full conversion was obtained without kinetic or transport limitations at the conditions applied. At 800 and 900 degrees C, the measured conversions were lower than the equilibrium predictions, indicating that the reactions were either...

Molecular epidemiology of Klebsiella pneumoniae K1 and K2 isolates in Japan.

Science.gov (United States)

Harada, Sohei; Ishii, Yoshikazu; Saga, Tomoo; Aoki, Kotaro; Tateda, Kazuhiro

2018-03-20

Although severe infections caused by hypervirulent Klebsiella pneumoniae isolates, such as K1 isolates belonging to sequence type (ST) 23, have been a significant problem in Asian countries, epidemiology of these isolates in Japan remains unclear. We performed a nationwide molecular epidemiological study of K. pneumoniae K1 and K2 isolates in Japan. Of the 259K. pneumoniae isolates collected, 14 and 16 isolates were identified as capsular genotypes K1 and K2, respectively. All K1 isolates were ST23 or its closely related clones and showed high genetic similarity by pulsed-field gel electrophoresis (PFGE) and the DiversiLab system (DL). K2 isolates, belonging to ST14, ST25, ST65, ST86, and ST110, were more genetically diverse than K1 isolates. Isolates belonging to a specific ST showed identical virulence gene profiles with a few exceptions. PFGE and DL results using K1 and K2 isolates were generally in agreement. Copyright © 2018. Published by Elsevier Inc.

Giant strain with low cycling degradation in Ta-doped [Bi_1_/_2(Na_0_._8K_0_._2)_1_/_2]TiO_3 lead-free ceramics

International Nuclear Information System (INIS)

Liu, Xiaoming; Tan, Xiaoli

2016-01-01

Non-textured polycrystalline [Bi_1_/_2(Na_0_._8K_0_._2)_1_/_2](Ti_1_−_xTa_x)O_3 ceramics are fabricated and their microstructures and electrical properties are characterized. Transmission electron microscopy reveals the coexistence of the rhombohedral R3c and tetragonal P4bm phases in the form of nanometer-sized domains in [Bi_1_/_2(Na_0_._8K_0_._2)_1_/_2]TiO_3 with low Ta concentration. When the composition is x = 0.015, the electrostrain is found to be highly asymmetric under bipolar fields of ±50 kV/cm. A very large value of 0.62% is observed in this ceramic, corresponding to a large-signal piezoelectric coefficient d_3_3* of 1240 pm/V (1120 pm/V under unipolar loading). These values are greater than most previously reported lead-free polycrystalline ceramics and can even be compared with some lead-free piezoelectric single crystals. Additionally, this ceramic displays low cycling degradation; its electrostrain remains above 0.55% even after undergoing 10 000 cycles of ±50 kV/cm bipolar fields at 2 Hz. Therefore, Ta-doped [Bi_1_/_2(Na_0_._8K_0_._2)_1_/_2]TiO_3 ceramics show great potential for large displacement devices.

LEAPing on with language: An on-line language programme to support classroom teachers and parents of primary school children (aged 5-11 years).

Science.gov (United States)

Clare Allen, M; Kendrick, Andrew; Archbold, Sue; Harrigan, Suzanne

2014-05-01

The Leaping on with Language programme provides a combination of strategies and activities to accelerate children's spoken language use from simple sentences to complex language. Using a conversational philosophy it expands the building blocks of language (vocabulary, grammar, speech), whilst emphasising the importance of developing independent social communication and acknowledging a child's developing self esteem and self identity between the ages of 4-11. Three pilot projects evaluated the programme with a total of 51 delegates. The outcomes were hugely positive. Changes in behaviour were reported from the 3rd pilot 1 month later. Comments regarding the length of training, practical strategies and more film clips were implemented. Leaping on with language is now a free to access resource available on line.

Online Appendix to Y2K

OpenAIRE

Stephanie Schmitt-Grohe; Martin Uribe

1998-01-01

As the millenium draws to an end, the threat posed by the Year 2000 (Y2K) problem is inducing vast private and public spending on its remediation. In this paper, we embed the Y2K problem into a dynamic general equilibrium framework. We model the Y2K problem as an anticipated, permanent loss to output whose magnitude can be lessened by investing resources in advance. Our model replicates three observed characteristics of the dynamics triggered by the Y2K bug: (1) Precautionary investment: inve...

Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo.

Science.gov (United States)

Hitomi, Misuzu; Yokoyama, Fumi; Kita, Yuko; Nonomura, Takako; Masaki, Tsutomu; Yoshiji, Hitoshi; Inoue, Hideyuki; Kinekawa, Fumihiko; Kurokohchi, Kazutaka; Uchida, Naohito; Watanabe, Seishiro; Kuriyama, Shigeki

2005-03-01

A number of studies have shown that various K vitamins, specifically vitamins K2 and K3, possess antitumor activity on various types of rodent- and human-derived neoplastic cell lines. In the present study, we examined the antitumor effects of vitamins K1, K2 and K3 on PLC/PRF/5 human hepatocellular carcinoma (HCC) cells in vitro and in vivo. Furthermore, we examined the mechanisms of antitumor actions of these vitamins in vitro and in vivo. Although vitamin K1 did not inhibit proliferation of PLC/PRF/5 cells at a 90-microM concentration (the highest tested), vitamins K2 and K3 suppressed proliferation of the cells at concentrations of 90 and 9 microM, respectively. By flow cytometric analysis, it was shown that not only vitamin K1, but also vitamin K2 did not induce apoptosis or cell cycle arrest on PLC/PRF/5 cells. In contrast, vitamin K3 induced G1 arrest, but not apoptosis on PLC/PRF/5 cells. Subsequent in vivo study using subcutaneous HCC-bearing athymic nude mice demonstrated that both vitamins K2 and K3 markedly suppressed the growth of HCC tumors to similar extent. Protein expression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4), but not p16INK4a Cdk inhibitor in the tumor was significantly reduced by vitamin K2 or K3 treatment, indicating that vitamins K2 and K3 may induce G1 arrest of cell cycle on PLC/PRF/5 cells in vivo. Taken collectively, vitamins K2 and K3 were able to induce potent antitumor effects on HCC in vitro and in vivo, at least in part, by inducing G1 arrest of the cell cycle. The results indicate that vitamins K2 and K3 may be useful agents for the treatment of patients with HCC.

K2 & Solar System Science

Science.gov (United States)

Lissauer, Jack

2015-01-01

All of the fields that K2 observes are near the ecliptic plane in order to minimize the spin-up of the spacecraft in response to the effects of solar irradiation. The fields observed by K2 are thus rich in Solar System objects including planets, asteroids and trans-Neptunian objects (TNOs). K2 has already performed observations of Neptune and its large moon Triton, 68 Trojan and Hilda asteroids, 5 TNOs (including Pluto) and Comet C/2013 A1 (Siding Springs). About 10,000 main-belt asteroids that fell into the pixel masks of stars have been serendipitously observed. Observations of small bodies are especially useful for determining rotation periods. Uranus will be observed in a future campaign (C8), as will many more small Solar System bodies. The status of various K2 Solar System studies will be reviewed and placed within the context of our current knowledge of the objects being observed.

Vitamin K2-enhanced liver regeneration is associated with oval cell expansion and up-regulation of matrilin-2 expression in 2-AAF/PH rat model.

Science.gov (United States)

Lin, M; Sun, P; Zhang, G; Xu, X; Liu, G; Miao, H; Yang, Y; Xu, H; Zhang, L; Wu, P; Li, M

2014-03-01

Normal liver has a great potential of regenerative capacity after partial hepatectomy. In clinic, however, most patients receiving partial hepatectomy are usually suffering from chronic liver diseases with severely damaged hepatocyte population. Under these conditions, activation of hepatic progenitor cell (oval cell in rodents) population might be considered as an alternative mean to enhance liver functional recovery. Vitamin K2 has been shown to promote liver functional recovery in patients with liver cirrhosis. In this study, we explored the possibility of vitamin K2 treatment in activating hepatic oval cell for liver regeneration with the classic 2-acetamido-fluorene/partial hepatectomy (2-AAF/PH) model in Sprague-Dawley rats. In 2-AAF/PH animals, vitamin K2 treatment induced a dose-dependent increase of liver regeneration as assessed by the weight ratio of remnant liver versus whole body and by measuring serum albumin level. In parallel, a drastic expansion of oval cell population as assessed by anti-OV6 and anti-CK19 immunostaining was noticed in the periportal zone of the remnant liver. Since matrilin-2 was linked to oval cell proliferation and liver regeneration after partial hepatectomy, we assessed its expression at both the mRNA and protein levels. The results revealed a significant increase after vitamin K2 treatment in parallel with the expansion of oval cell population. Consistently, knocking down matrilin-2 expression in vivo largely reduced vitamin K2-induced liver regeneration and oval cell proliferation in 2-AAF/PH animals. In conclusion, these data suggest that vitamin K2 treatment enhances liver regeneration after partial hepatectomy, which is associated with oval cell expansion and matrilin-2 up-regulation.

Flux-coherent series SQUID array magnetometers operating above 77 K with superior white flux noise than single-SQUIDs at 4.2 K

Energy Technology Data Exchange (ETDEWEB)

Chesca, Boris, E-mail: B.Chesca@lboro.ac.uk; John, Daniel [Department of Physics, Loughborough University, Loughborough LE11 3TU (United Kingdom); Mellor, Christopher J. [School of Physics and Astronomy, Nottingham University, Nottingham NG7 2RD (United Kingdom)

2015-10-19

A very promising direction to improve the sensitivity of magnetometers based on superconducting quantum interference devices (SQUIDs) is to build a series-array of N non-interacting SQUIDs operating flux-coherently, because in this case their voltage modulation depth, ΔV, linearly scales with N whereas the white flux noise S{sub Φ}{sup 1/2} decreases as 1/N{sup 1/2}. Here, we report the realization of both these improvements in an advanced layout of very large SQUID arrays made of YBa{sub 2}Cu{sub 3}O{sub 7}. Specially designed with large area narrow flux focusers for increased field sensitivity and improved flux-coherency, our arrays have extremely low values for S{sub Φ}{sup 1/2} between (0.25 and 0.44) μΦ{sub 0}/Hz{sup 1/2} for temperatures in the range (77–83) K. In this respect, they outperform niobium/aluminium trilayer technology-based single-SQUIDs operating at 4.2 K. Moreover, with values for ΔV and transimpedance in the range of (10–17) mV and (0.3–2.5) kΩ, respectively, a direct connection to a low-noise room temperature amplifier is allowed, while matching for such readout is simplified and the available bandwidth is greatly increased. These landmark performances suggest such series SQUID arrays are ideal candidates to replace single-SQUIDs operating at 4.2 K in many applications.

Star clusters and K2

Science.gov (United States)

Dotson, Jessie; Barentsen, Geert; Cody, Ann Marie

2018-01-01

The K2 survey has expanded the Kepler legacy by using the repurposed spacecraft to observe over 20 star clusters. The sample includes open and globular clusters at all ages, including very young (1-10 Myr, e.g. Taurus, Upper Sco, NGC 6530), moderately young (0.1-1 Gyr, e.g. M35, M44, Pleiades, Hyades), middle-aged (e.g. M67, Ruprecht 147, NGC 2158), and old globular clusters (e.g. M9, M19, Terzan 5). K2 observations of stellar clusters are exploring the rotation period-mass relationship to significantly lower masses than was previously possible, shedding light on the angular momentum budget and its dependence on mass and circumstellar disk properties, and illuminating the role of multiplicity in stellar angular momentum. Exoplanets discovered by K2 in stellar clusters provides planetary systems ripe for modeling given the extensive information available about their ages and environment. I will review the star clusters sampled by K2 across 16 fields so far, highlighting several characteristics, caveats, and unexplored uses of the public data set along the way. With fuel expected to run out in 2018, I will discuss the closing Campaigns, highlight the final target selection opportunities, and explain the data archive and TESS-compatible software tools the K2 mission intends to leave behind for posterity.

Y2K Resources for Public Libraries.

Science.gov (United States)

Foster, Janet

1999-01-01

Presents information for public libraries on computer-related vulnerabilities as the century turns from 1999 to 2000. Highlights include: general Y2K information; the Y2K Bug and PCs; Y2K sites for librarians; Online Computer Library Center (OCLC) and USMARC; technological developments in cyberspace; and a list of Web sites and Y2K resources. (AEF)

The grand leap of the whale up the Niagara Falls: converting philosophical conclusions into policy prescriptions.

Science.gov (United States)

Holm, Søren

2015-04-01

This article analyzes a neat conjuring trick employed in bioethics, that is, the immediate conversion of a philosophical conclusion into a policy prescription, and compares it to the "grand leap of the whale up the Niagara Falls" mentioned by Benjamin Franklin. It is shown that there is no simple and easy way to achieve the conversion, by considering arguments falling under four headings: (1) reasonable disagreement about values and theories, (2) general jurisprudential arguments, (3) the differences between policymaking and philosophy, and (4) the messy world of implementation. The particular issue used to illustrate the difficulties in moving from philosophical conclusion to policy description is infanticide of healthy infants, but the analysis is general, and the conclusion that the immediate move to policy is illegitimate is quite general.

Theoretical investigation of the Omega(g,u)(+/-) states of K2 dissociating adiabatically up to K(4p 2P(3/2)) + K(4p 2P(3/2)).

Science.gov (United States)

Jraij, A; Allouche, A R; Magnier, S; Aubert-Frécon, M

2009-06-28

A theoretical investigation of the electronic structure of the K(2) molecule, including spin-orbit effects, has been performed. Potential energies have been calculated over a large range of R up to 75a(0) for the 88 Omega(g,u)(+/-) states dissociating adiabatically into the limits up to K(4p (2)P(3/2))+K(4p (2)P(3/2)). Equilibrium distances, transition energies, harmonic frequencies, as well as depths for wells and heights for barriers are reported for all of the bound Omega(g,u)(+/-) states. Present ab initio calculations are shown to be able to reproduce quite accurately the small structures (wells and barrier) displayed at very long-range (R>50a(0)) by the (2,3)1(u) and (2)0(g)(-) purely long-range states. As the present data could help experimentalists, we make available extensive tables of energy values versus internuclear distances in our database at the web address http://www-lasim.univ-lyon1.fr/spip.php?rubrique99.

Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation.

Science.gov (United States)

Fischer, Heinz; Langbein, Lutz; Reichelt, Julia; Praetzel-Wunder, Silke; Buchberger, Maria; Ghannadan, Minoo; Tschachler, Erwin; Eckhart, Leopold

2014-10-01

Keratin K2 is one of the most abundant structural proteins of the epidermis; however, its biological significance has remained elusive. Here we show that suprabasal type II keratins, K1 and K2, are expressed in a mutually exclusive manner at different body sites of the mouse, with K2 being confined to the ear, sole, and tail skin. Deletion of K2 caused acanthosis and hyperkeratosis of the ear and the tail epidermis, corneocyte fragility, increased transepidermal water loss, and local inflammation in the ear skin. The loss of K2 was partially compensated by upregulation of K1 expression. However, a significant portion of K2-deficient suprabasal keratinocytes lacked a regular cytoskeleton and developed massive aggregates of the type I keratin, K10. Aggregate formation, but not hyperkeratosis, was suppressed by the deletion of both K2 and K10, whereas deletion of K10 alone caused clumping of K2 in ear skin. Taken together, this study demonstrates that K2 is a necessary and sufficient binding partner of K10 at distinct body sites of the mouse and that unbalanced expression of these keratins results in aggregate formation.

Keratins K2 and K10 are essential for the epidermal integrity of plantar skin.

Science.gov (United States)

Fischer, Heinz; Langbein, Lutz; Reichelt, Julia; Buchberger, Maria; Tschachler, Erwin; Eckhart, Leopold

2016-01-01

K1 and K2 are the main type II keratins in the suprabasal epidermis where each of them heterodimerizes with the type I keratin K10 to form intermediate filaments. In regions of the ears, tail, and soles of the mouse, only K2 is co-expressed with K10, suggesting that these keratins suffice to form a mechanically resilient cytoskeleton. To determine the effects of the suppression of both main keratins, K2 and K10, in the suprabasal plantar epidermis of the mouse. Krt2(-/-) Krt10(-/-) mice were generated by crossing Krt2(-/-) and Krt10(-/-) mice. Epidermal morphology of soles of hind-paws was examined macroscopically and histologically. Immunofluorescence analysis and quantitative PCR analysis were performed to analyze the expression of keratins in sole skin of wildtype and Krt2(-/-) Krt10(-/-) mice. Highly abundant proteins of the sole stratum corneum were determined by electrophoretic and chromatographic separation and subsequent mass spectrometry. K2 and K10 are the most prominent suprabasal keratins in normal mouse soles with the exception of the footpads where K1, K9 and K10 predominate. Mice lacking both K2 and K10 were viable and developed epidermal acanthosis and hyperkeratosis in inter-footpad epidermis of the soles. The expression of keratins K1, K9 and K16 was massively increased at the RNA and protein levels in the soles of Krt2(-/-) Krt10(-/-) mice. This study demonstrates that the loss of the main cytoskeletal components of plantar epidermis, i.e. K2 and K10, can be only partly compensated by the upregulation of other keratins. The thickening of the epidermis in the soles of Krt2(-/-) Krt10(-/-) mice may serve as a model for pathomechanistic aspects of palmoplantar keratoderma. Copyright © 2015. Published by Elsevier Ireland Ltd.

LEAPing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introduction.

Science.gov (United States)

Greenhawt, M; Fleischer, D M; Chan, E S; Venter, C; Stukus, D; Gupta, R; Spergel, J M

2017-08-01

In the Learning Early About Peanut Allergy (LEAP) study, early peanut introduction in high-risk 4- to 11-month-olds was associated with a significantly decreased risk of developing peanut allergy. However, the influences of key baseline high-risk factors on peanut tolerance are poorly understood. Secondary analysis was conducted on the publically available LEAP dataset, exploring relationships between peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduction, gender, and race. A multiple logistic regression model predicting odds of successful oral food challenge (OFC) at 60 months noted higher odds with early introduction (OR 9.2, P introduction group was 83% vs 43% in the avoidance group with SPT wheal of introduction between 6 and 11 months than at 4-6 months. Increasing eczema severity had limited impact on the probability of peanut tolerance in the early introduction arm. Increasing peanut wheal size predicted peanut tolerance only in the avoidance arm. Peanut introduction between 6 and 11 months of age was associated with the highest rates of peanut tolerance, questioning the 'urgency' of introduction before 6 months. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Environmental and economic assessment of the chemical absorption process in Korea using the LEAP model

International Nuclear Information System (INIS)

Song, Ho-Jun; Lee, Seungmoon; Maken, Sanjeev; Ahn, Se-Woong; Park, Jin-Won; Min, Byoungryul; Koh, Wongun

2007-01-01

CO 2 emission from fossil fuels is a major cause for the global warming effect, but it is hard to remove completely in actuality. Moreover, energy consumption is bound to increase for the continuous economic development of a country that has an industrial formation requiring high-energy demand. Therefore, we need to consider not only a device for CO 2 mitigation but also its impact when a CO 2 mitigation device is applied. The device for CO 2 emission mitigation can be classified into three fields: energy consumption reduction, development of CO 2 removal and recovery technology, and development of alternative energy technology. Among these options, CO 2 removal and recovery technology has a merit that can be applied to a process in the near future. Therefore, research for CO 2 removal and recovery is actively progressing in Korea. In this study, environmental and economic assessment according to the energy policy change for climate change agreement and increase of CO 2 mitigation technology is accomplished, on the bases of operating data for the CO 2 chemical absorption pilot plant that is installed in the Seoul coal steam power plant. The Long-range Energy Alternatives Planning system (LEAP) was used to analyze the alternative scenario, and results were shown quantitatively

Study on the thermoluminescent properties of K2YF5 and K2GdF5 crystals doped with optically active trivalent ions for gamma and neutrons dosimetry

International Nuclear Information System (INIS)

Silva, Edna Carla da

2008-01-01

In this work, the thermoluminescent (TL) properties of both double potassium yttrium fluoride (K 2 YF 5 ) and double potassium gadolinium fluoride (K 2 GdF 5 ) crystals doped with optically active rare earth ions were investigated from the point of view of gamma and neutron dosimetry. Crystalline platelets with thickness of about 1 mm, synthesized under hydrothermal conditions, were irradiated in order to study TL sensitivity, as well as dose and energy response, reproducibility and fading, in terms of Ce 3+ , Tb 3+ , Dy 3+ , e Pr 3+ concentrations. The K 2 YF 5 crystals doped with 1.0 at por cent Dy 3+ have been found to have an excellent linear TL response to X and gamma photons, in the range of 0.01 to 10 mGy. The TL output is comparable to that of CaS0 4 :Mn dosemeters. The main peak at 130 deg C has been found to have a TL response for 41.1 keV X-ray energy 32 times higher than that for 662 keV gamma rays. This fact points out that the K 2 Y 0.99 Dy 0.01 F 5 crystals have great potential for X-rays diagnostic and/or industrial radiography. On the other hand, the K 2 GdF 5 crystals doped with 5.0 at por cent Dy 3+ have been found to have the better TL response for gamma and fast neutron radiation, among the dopants studied. For gamma fields the TL response was linear for doses ranging from 0.1 to 200 mGy. The TL peak around 200 deg C can be deconvoluted into four individual peaks, all of them with linear behavior. For fast neutron radiation produced by an 241 Am B e source, the TL responses for doses ranging from 0.6 to 12 mSv were also linear and comparable to that of commercial TLD-600, irradiated at same conditions. The TL emission due to neutrons was in the high temperature range, above 200 deg C. These results points out that K 2 Gd 0.95 Dy 0.05 F 5 crystals are good candidates for use in neutron dosimetry applications. (author)

Synthetic marijuana "K2" induced ITP.

Science.gov (United States)

Öztürk, Erman; Oral, Alihan; Özdemir, Melek; Bambul, Nail

2015-01-01

Immune thrombocytopenia (ITP) is a heterogeneous disease which can be primary or secondary due to other conditions such as drugs. CB2 receptors (CB2R) also have a role in the ITP pathogenesis as CB2 receptor gene (CNR2) polymorphisms are associated with chronic immune thrombocytopenia and autoimmune diseases. K2 is synthetic marijuana which acts on cannabinoid receptors that are found on immune cells and thrombocytes. Here, we present a case who presented with ITP secondary to K2 usage and was successfully treated with 1 mg/kg prednisolone. This is the first ITP case in the literature due to K2. It is important in the era of the new drugs development of the CB2R mimetics.

Path representation of su-hat (2){sub k} states I: Operators and particles for k=1,2

Energy Technology Data Exchange (ETDEWEB)

Lamy-Poirier, Joel, E-mail: jlamypoirier@perimeterinstitute.c [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, G1K 7P4 (Canada); Mathieu, Pierre, E-mail: pmathieu@phy.ulaval.c [Departement de physique, de genie physique et d' optique, Universite Laval, Quebec, G1K 7P4 (Canada)

2011-04-11

This is the first of two articles devoted to the analysis of the path description of the states in su-hat (2){sub k} WZW models, a representation well suited for constructive derivations of the fermionic characters. In this first article, the cases k=1,2 are treated in detail, emphasizing a different description in each case (operators vs particles). For k=1, we first prove, as a side result, the equivalence of two known path representations for the finitized su-hat (2){sub 1} states by displaying an explicit bijection. An immediate offshoot is the gain of a new and simple weighting for the (Kyoto) path representation that generalizes to level k. The bijection also suggests two operator constructions for the su-hat (2){sub 1} paths, a local and a nonlocal one, both interrelated. These are formal operators that map a path to another path, so that any path can be obtained by successive applications of these operators on a simple reference (ground-state) path. The nonlocal operator description is the starting point for a direct and elementary derivation of the su-hat (2){sub 1} spinon character. The second part presents an extensive study of the su-hat (2){sub 2} paths from their particle point of view, where the particles are defined as the path building blocks. The resulting generating functions appear to provide new (at least superficially) fermionic forms of the characters. In particular, a nice relationship between the sum of the j=0,1 characters at k=2 and the two ones at k=1 is unraveled.

{sup 57}Fe Mössbauer spectroscopic studies of single-crystalline K{sub x}Fe{sub 2-y}S{sub 2} and K{sub x}Fe{sub 2-y}Se{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Tsuchiya, Yuu, E-mail: tsuchiya.yuu1990@gmail.com; Ikeda, Shugo; Kobayashi, Hisao [University of Hyogo (Japan)

2016-12-15

We have investigated the physical properties of single-crystalline K{sub x}Fe{sub 2-y}S{sub 2} and K{sub x}Fe{sub 2-y}Se{sub 2} samples using {sup 57}Fe Mössbauer spectroscopy. The observed {sup 57}Fe Mössbauer spectra were reconstructed using a major antiferromagnetic ordered K{sub 2}Fe{sub 4}Se{sub 5} phase and a minor paramagnetic phase down to 5 K, despite being superconducting below 32.2 K in K{sub x}Fe{sub 2-y}Se{sub 2}. The analysis of {sup 57}Fe Mössbauer spectrum for K{sub x}Fe{sub 2-y}S{sub 2} at 290 K confirms the presence of a major antiferromagnetic ordered K{sub 2}Fe{sub 4}S{sub 5} phase and a minor paramagnetic phase in the K{sub x}Fe{sub 2-y}S{sub 2} single crystal. The derived hyperfine interaction parameters of the paramagnetic phase in K{sub x}Fe{sub 2-y}S{sub 2} suggest that the microstructure of this phase in K{sub x}Fe{sub 2-y}S{sub 2} is similar to that of the superconducting phase in K{sub x}Fe{sub 2-y}Se{sub 2} although the K{sub x}Fe{sub 2-y}S{sub 2} single crystals exhibit no superconductivity down to 5 K.

Resolving power test of 2-D K+ K+ interferometry

International Nuclear Information System (INIS)

Padula, Sandra S.; Roldao, Christiane G.

1999-01-01

Adopting a procedure previously proposed to quantitatively study pion interferometry 1 , an equivalent 2-D X 2 analysis was performed to test the resolving power of that method when applied to less favorable conditions, when no significant contribution from long lived resonances is expected, as in kaon interferometry. For that purpose, use is made of the preliminary E859 K + K + interferometry data from Si+Au collisions at 14.6 A GeV/c. Less sensitivity is achieved in the present case, although it is shown that it is still possible to distinguish two distinct decoupling geometries. (author)

Planet Hunters 2 in the K2 Era

Science.gov (United States)

Schwamb, Megan E.; Fischer, Debra; Boyajian, Tabetha S.; Giguere, Matthew J.; Ishikawa, Sascha; Lintott, Chris; Lynn, Stuart; Schmitt, Joseph; Snyder, Chris; Wang, Ji; Barclay, Thomas

2015-01-01

Planet Hunters (http://www.planethunters.org) is an online citizen science project enlisting hundreds of thousands of people to search for planet transits in the publicly released Kepler data. Volunteers mark the locations of visible transits in a web interface, with multiple independent classifiers reviewing a randomly selected ~30-day light curve segment. In September 2014, Planet Hunters entered a new phase. The project was relaunched with a brand new online classification interface and discussion tool built using the Zooniverse's (http://www.zooniverse.org) latest technology and web platform. The website has been optimized for the rapid discovery and identification of planet candidates in the light curves from K2, the two-wheeled ecliptic plane Kepler mission. We will give an overview of the new Planet Hunters classification interface and Round 2 review system in context of the K2 data. We will present the first results from the Planet Hunters 2 search of K2 Campaigns 0 and 1 including a summary of new planet candidates.

Transiting Planets from Kepler, K2 & TESS

Science.gov (United States)

Lissauer, Jack

2018-01-01

NASA's Kepler spacecraft, launched in 2009, has been a resounding success. More than 4000 planet candidates have been identified using data from Kepler primary mission, which ended in 2013, and greater than 2000 of these candidates have been verified as bona fide exoplanets. After the loss of two reaction wheels ended the primary mission, the Kepler spacecraft was repurposed in 2014 to observe many fields on the sky for short periods. This new mission, dubbed K2, has led to the discovery of greater than 600 planet candidates, approximately 200 of which have been verified to date; most of these exoplanets are closer to us than the majority of exoplanets discovered by the primary Kepler mission. TESS, launching in 2018, will survey most of the sky for exoplanets, with emphasis on those orbiting nearby and/or bright host stars, making these planets especially well-suited for follow-up observations with other observatories to characterize atmospheric compositions and other properties. More than one-third of the planet candidates found by NASA's are associated with target stars that have more than one planet candidate, and such 'multis' account for the majority of candidates that have been verified as true planets. The large number of multis tells us that flat multiplanet systems like our Solar System are common. Virtually all of the candidate planetary systems are stable, as tested by numerical integrations that assume a physically motivated mass-radius relationship. Statistical studies performed on these candidate systems reveal a great deal about the architecture of planetary systems, including the typical spacing of orbits and flatness. The characteristics of several of the most interesting confirmed Kepler & K2 multi-planet systems will also be discussed.

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

Science.gov (United States)

Schewe, Marcus; Nematian-Ardestani, Ehsan; Sun, Han; Musinszki, Marianne; Cordeiro, Sönke; Bucci, Giovanna; de Groot, Bert L; Tucker, Stephen J; Rapedius, Markus; Baukrowitz, Thomas

2016-02-25

Two-pore domain (K2P) K(+) channels are major regulators of excitability that endow cells with an outwardly rectifying background "leak" conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. Here, we show voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric field of an inactive selectivity filter. Overall, this ion-flux gating mechanism generates a one-way "check valve" within the filter because outward movement of K(+) induces filter opening, whereas inward movement promotes inactivation. Furthermore, many physiological stimuli switch off this flux gating mode to convert K2P channels into a leak conductance. These findings provide insight into the functional plasticity of a K(+)-selective filter and also refine our understanding of K2P channels and the mechanisms by which ion channels can sense voltage. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Observation of the decay $\\overline{B_s^0} \\rightarrow \\chi_{c2} K^+ K^- $

CERN Document Server

Aaij, R.; LHCb Collaboration; Adinolfi, M.; Aidala, C.A.; Ajaltouni, Z.; Akar, S.; Albicocco, P.; Albrecht, J.; Alessio, F.; Alexander, M.; Albero, A. Alfonso; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A.A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Andreassi, G.; Andreotti, M.; Andrews, J.E.; Appleby, R.B.; Archilli, F.; d'Argent, P.; Arnau Romeu, J.; Artamonov, A.; Artuso, M.; Arzymatov, K.; Aslanides, E.; Atzeni, M.; Bachmann, S.; Back, J.J.; Baker, S.; Balagura, V.; Baldini, W.; Baranov, A.; Barlow, R.J.; Barsuk, S.; Barter, W.; Baryshnikov, F.; Batozskaya, V.; Batsukh, B.; Battista, V.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Beiter, A.; Bel, L.J.; Beliy, N.; Bellee, V.; Belloli, N.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Beranek, S.; Berezhnoy, A.; Bernet, R.; Berninghoff, D.; Bertholet, E.; Bertolin, A.; Betancourt, C.; Betti, F.; Bettler, M.O.; van Beuzekom, M.; Bezshyiko, Ia.; Bhasin, S.; Bhom, J.; Bian, L.; Bifani, S.; Billoir, P.; Birnkraut, A.; Bizzeti, A.; Bjørn, M.; Blago, M.P.; Blake, T.; Blanc, F.; Blusk, S.; Bobulska, D.; Bocci, V.; Garcia, O. 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Poli; Poluektov, A.; Polukhina, N.; Polyakov, I.; Polycarpo, E.; Pomery, G.J.; Ponce, S.; Popov, A.; Popov, D.; Poslavskii, S.; Potterat, C.; Price, E.; Prisciandaro, J.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Pullen, H.; Punzi, G.; Qian, W.; Qin, J.; Quagliani, R.; Quintana, B.; Rachwal, B.; Rademacker, J.H.; Rama, M.; Ramos Pernas, M.; Rangel, M.S.; Ratnikov, F.; Raven, G.; Ravonel Salzgeber, M.; Reboud, M.; Redi, F.; Reichert, S.; dos Reis, A.C.; Reiss, F.; Remon Alepuz, C.; Ren, Z.; Renaudin, V.; Ricciardi, S.; Richards, S.; Rinnert, K.; Robbe, P.; Robert, A.; Rodrigues, A.B.; Rodrigues, E.; Rodriguez Lopez, J.A.; Roehrken, M.; Rogozhnikov, A.; Roiser, S.; Rollings, A.; Romanovskiy, V.; Romero Vidal, A.; Rotondo, M.; Rudolph, M.S.; Ruf, T.; Ruiz Vidal, J.; Saborido Silva, J.J.; Sagidova, N.; Saitta, B.; Salustino Guimaraes, V.; Gras, C. Sanchez; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santimaria, M.; Santovetti, E.; Sarpis, G.; Sarti, A.; Satriano, C.; Satta, A.; Saur, M.; Savrina, D.; Schael, S.; Schellenberg, M.; Schiller, M.; Schindler, H.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schreiner, H.F.; Schubiger, M.; Schune, M.H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepulveda, E.S.; Sergi, A.; Serra, N.; Serrano, J.; Sestini, L.; Seuthe, A.; Seyfert, P.; Shapkin, M.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shmanin, E.; Siddi, B.G.; Silva Coutinho, R.; Silva de Oliveira, L.; Simi, G.; Simone, S.; Skidmore, N.; Skwarnicki, T.; Smeaton, J.G.; Smith, E.; Smith, I.T.; Smith, M.; Soares, M.; Soares Lavra, l.; Sokoloff, M.D.; Soler, F.J.P.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Stagni, F.; Stahl, M.; Stahl, S.; Stefko, P.; Stefkova, S.; Steinkamp, O.; Stemmle, S.; Stenyakin, O.; Stepanova, M.; Stevens, H.; Stone, S.; Storaci, B.; Stracka, S.; Stramaglia, M.E.; Straticiuc, M.; Straumann, U.; Strokov, S.; Sun, J.; Sun, L.; Swientek, K.; Syropoulos, V.; Szumlak, T.; Szymanski, M.; T'Jampens, S.; Tang, Z.; Tayduganov, A.; Tekampe, T.; Tellarini, G.; Teubert, F.; Thomas, E.; van Tilburg, J.; Tilley, M.J.; Tisserand, V.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Tou, D.Y.; Aoude, R. Tourinho Jadallah; Tournefier, E.; Traill, M.; Tran, M.T.; Trisovic, A.; Tsaregorodtsev, A.; Tully, A.; Tuning, N.; Ukleja, A.; Usachov, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagner, A.; Vagnoni, V.; Valassi, A.; Valat, S.; Valenti, G.; Vazquez Gomez, R.; Regueiro, P. 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2018-01-01

The $\\overline{B_s^0} \\rightarrow \\chi_{c2} K^+ K^- $ decay mode is observed and its branching fraction relative to the corresponding $\\chi_{c1}$ decay mode, in a $\\pm 15 \\textrm{MeV}/c^2$ window around the $\\phi$ mass, is found to be $$\\frac{\\mathcal{B}(\\overline{B_s^0} \\rightarrow \\chi_{c2} K^+ K^-) }{ \\mathcal{B}(\\overline{B_s^0} \\rightarrow \\chi_{c1} K^+K^-)} = (17.1 \\pm 3.1 \\pm 0.4 \\pm 0.9)\\%,$$ where the first uncertainty is statistical, the second systematic and the third due to the knowledge of the branching fractions of radiative $\\chi_c$ decays. The decay mode $\\overline{B_s^0} \\rightarrow \\chi_{c1} K^+ K^- $ allows the $ B_s^0$ mass to be measured as $$m(B_s^0) = 5366.83 \\pm 0.25 \\pm 0.27 \\, \\textrm{MeV}/c^2,$$ where the first uncertainty is statistical and the second systematic.

Structural Motion Grammar for Universal Use of Leap Motion: Amusement and Functional Contents Focused

Directory of Open Access Journals (Sweden)

Byungseok Lee

2018-01-01

Full Text Available Motions using Leap Motion controller are not standardized while the use of it is spreading in media contents. Each content defines its own motions, thereby creating confusion for users. Therefore, to alleviate user inconvenience, this study categorized the commonly used motion by Amusement and Functional Contents and defined the Structural Motion Grammar that can be universally used based on the classification. To this end, the Motion Lexicon was defined, which is a fundamental motion vocabulary, and an algorithm that enables real-time recognition of Structural Motion Grammar was developed. Moreover, the proposed method was verified by user evaluation and quantitative comparison tests.

Development on UO3-K2O and MoO3-K2O binary systems and study of UO2MoO4-MoO3 domain within UO3-MoO3-K2O ternary system

International Nuclear Information System (INIS)

Dion, C.; Noel, A.

1983-01-01

This paper confirms the previous study on the MoO 3 -K 2 O system, and constitutes a clarity of the UO 3 -K 2 O system. Four distinct uranates VI with alkaline metal/uranium ratio's 2, 1, 0,5 and 0,285 exist. Preparation conditions and powder diffraction spectra of these compounds are given. Additional informations relative to K 2 MoO 4 allotropic transformations are provided. Study of UO 2 MoO 4 -K 2 MoO 4 diagram has brought three new phases into prominence: (B) K 6 UMo 4 O 18 incongruently melting point, (E) K 2 UMo 2 O 10 congruently melting and (F) K 2 U 3 Mo 4 O 22 incongruently melting point. Within MoO 3 -K 2 MoO 4 -UO 2 MoO 4 ternary system, no new phase is found. The general appearance of ternary liquidus and crystallization fields of several compounds are given. These three new compounds become identified with these of UO 2 MoO 4 -Na 2 MoO 4 binary system [fr

High-precision 41K/39K measurements by MC-ICP-MS indicate terrestrial variability of δ41K

Science.gov (United States)

Morgan, Leah; Santiago Ramos, Danielle P.; Davidheiser-Kroll, Brett; Faithfull, John; Lloyd, Nicholas S.; Ellam, Rob M.; Higgins, John A.

2018-01-01

Potassium is a major component in continental crust, the fourth-most abundant cation in seawater, and a key element in biological processes. Until recently, difficulties with existing analytical techniques hindered our ability to identify natural isotopic variability of potassium isotopes in terrestrial materials. However, measurement precision has greatly improved and a range of K isotopic compositions has now been demonstrated in natural samples. In this study, we present a new technique for high-precision measurement of K isotopic ratios using high-resolution, cold plasma multi-collector mass spectrometry. We apply this technique to demonstrate natural variability in the ratio of 41K to 39K in a diverse group of geological and biological samples, including silicate and evaporite minerals, seawater, and plant and animal tissues. The total range in 41K/39K ratios is ca. 2.6‰, with a long-term external reproducibility of 0.17‰ (2, N=108). Seawater and seawater-derived evaporite minerals are systematically enriched in 41K compared to silicate minerals by ca. 0.6‰, a result consistent with recent findings1, 2. Although our average bulk-silicate Earth value (-0.54‰) is indistinguishable from previously published values, we find systematic δ41K variability in some high-temperature sample suites, particularly those with evidence for the presence of fluids. The δ41K values of biological samples span a range of ca. 1.2‰ between terrestrial mammals, plants, and marine organisms. Implications of terrestrial K isotope variability for the atomic weight of K and K-based geochronology are discussed. Our results indicate that high-precision measurements of stable K isotopes, made using commercially available mass spectrometers, can provide unique insights into the chemistry of potassium in geological and biological systems. 

Possible applications of the LEAP motion controller for more interactive simulated experiments in augmented or virtual reality

Science.gov (United States)

Wozniak, Peter; Vauderwange, Oliver; Mandal, Avikarsha; Javahiraly, Nicolas; Curticapean, Dan

2016-09-01

Practical exercises are a crucial part of many curricula. Even simple exercises can improve the understanding of the underlying subject. Most experimental setups require special hardware. To carry out e. g. a lens experiments the students need access to an optical bench, various lenses, light sources, apertures and a screen. In our previous publication we demonstrated the use of augmented reality visualization techniques in order to let the students prepare with a simulated experimental setup. Within the context of our intended blended learning concept we want to utilize augmented or virtual reality techniques for stationary laboratory exercises. Unlike applications running on mobile devices, stationary setups can be extended more easily with additional interfaces and thus allow for more complex interactions and simulations in virtual reality (VR) and augmented reality (AR). The most significant difference is the possibility to allow interactions beyond touching a screen. The LEAP Motion controller is a small inexpensive device that allows for the tracking of the user's hands and fingers in three dimensions. It is conceivable to allow the user to interact with the simulation's virtual elements by the user's very hand position, movement and gesture. In this paper we evaluate possible applications of the LEAP Motion controller for simulated experiments in augmented and virtual reality. We pay particular attention to the devices strengths and weaknesses and want to point out useful and less useful application scenarios.

Y2K: Focus on systems

International Nuclear Information System (INIS)

Dillner, M.

1999-01-01

During the past three years the Pacific Northwest National Laboratory has been actively working with the US DOE to understand the Y2K impacts that exist and perform appropriate remediation of critical systems. The Y2K problem has the potential for affecting software, hardware, embedded chips, control devices as well as telephone and power equipment. Successful Y2K remediation requires that a risk assessment be performed based on a view of the 'complete' system (e.g. input, outputs, infrastructure, operating systems, communication mechanisms, and development tools as compilers). All DOE facilities have followed the Y2K life cycle of system inventory, assessment (system and risk), renovation, testing, transition planning, implementation, validation and business continuity planning. Within this process, each organization has used the particular systems life-cycle methodology. The Pacific Northwest National Laboratory would like to share lessons learned about the entire Year 2000 program particularly in the areas of performing Year 2000 assessments, the identification of appropriate system remediation, and project mechanisms

Leap Motion-based virtual reality training for improving motor functional recovery of upper limbs and neural reorganization in subacute stroke patients

Science.gov (United States)

Wang, Zun-rong; Wang, Ping; Xing, Liang; Mei, Li-ping; Zhao, Jun; Zhang, Tong

2017-01-01

Virtual reality is nowadays used to facilitate motor recovery in stroke patients. Most virtual reality studies have involved chronic stroke patients; however, brain plasticity remains good in acute and subacute patients. Most virtual reality systems are only applicable to the proximal upper limbs (arms) because of the limitations of their capture systems. Nevertheless, the functional recovery of an affected hand is most difficult in the case of hemiparesis rehabilitation after a stroke. The recently developed Leap Motion controller can track the fine movements of both hands and fingers. Therefore, the present study explored the effects of a Leap Motion-based virtual reality system on subacute stroke. Twenty-six subacute stroke patients were assigned to an experimental group that received virtual reality training along with conventional occupational rehabilitation, and a control group that only received conventional rehabilitation. The Wolf motor function test (WMFT) was used to assess the motor function of the affected upper limb; functional magnetic resonance imaging was used to measure the cortical activation. After four weeks of treatment, the motor functions of the affected upper limbs were significantly improved in all the patients, with the improvement in the experimental group being significantly better than in the control group. The action performance time in the WMFT significantly decreased in the experimental group. Furthermore, the activation intensity and the laterality index of the contralateral primary sensorimotor cortex increased in both the experimental and control groups. These results confirmed that Leap Motion-based virtual reality training was a promising and feasible supplementary rehabilitation intervention, could facilitate the recovery of motor functions in subacute stroke patients. The study has been registered in the Chinese Clinical Trial Registry (registration number: ChiCTR-OCH-12002238). PMID:29239328

Leap Motion-based virtual reality training for improving motor functional recovery of upper limbs and neural reorganization in subacute stroke patients.

Science.gov (United States)

Wang, Zun-Rong; Wang, Ping; Xing, Liang; Mei, Li-Ping; Zhao, Jun; Zhang, Tong

2017-11-01

Virtual reality is nowadays used to facilitate motor recovery in stroke patients. Most virtual reality studies have involved chronic stroke patients; however, brain plasticity remains good in acute and subacute patients. Most virtual reality systems are only applicable to the proximal upper limbs (arms) because of the limitations of their capture systems. Nevertheless, the functional recovery of an affected hand is most difficult in the case of hemiparesis rehabilitation after a stroke. The recently developed Leap Motion controller can track the fine movements of both hands and fingers. Therefore, the present study explored the effects of a Leap Motion-based virtual reality system on subacute stroke. Twenty-six subacute stroke patients were assigned to an experimental group that received virtual reality training along with conventional occupational rehabilitation, and a control group that only received conventional rehabilitation. The Wolf motor function test (WMFT) was used to assess the motor function of the affected upper limb; functional magnetic resonance imaging was used to measure the cortical activation. After four weeks of treatment, the motor functions of the affected upper limbs were significantly improved in all the patients, with the improvement in the experimental group being significantly better than in the control group. The action performance time in the WMFT significantly decreased in the experimental group. Furthermore, the activation intensity and the laterality index of the contralateral primary sensorimotor cortex increased in both the experimental and control groups. These results confirmed that Leap Motion-based virtual reality training was a promising and feasible supplementary rehabilitation intervention, could facilitate the recovery of motor functions in subacute stroke patients. The study has been registered in the Chinese Clinical Trial Registry (registration number: ChiCTR-OCH-12002238).

Leap Motion-based virtual reality training for improving motor functional recovery of upper limbs and neural reorganization in subacute stroke patients

Directory of Open Access Journals (Sweden)

Zun-rong Wang

2017-01-01

Full Text Available Virtual reality is nowadays used to facilitate motor recovery in stroke patients. Most virtual reality studies have involved chronic stroke patients; however, brain plasticity remains good in acute and subacute patients. Most virtual reality systems are only applicable to the proximal upper limbs (arms because of the limitations of their capture systems. Nevertheless, the functional recovery of an affected hand is most difficult in the case of hemiparesis rehabilitation after a stroke. The recently developed Leap Motion controller can track the fine movements of both hands and fingers. Therefore, the present study explored the effects of a Leap Motion-based virtual reality system on subacute stroke. Twenty-six subacute stroke patients were assigned to an experimental group that received virtual reality training along with conventional occupational rehabilitation, and a control group that only received conventional rehabilitation. The Wolf motor function test (WMFT was used to assess the motor function of the affected upper limb; functional magnetic resonance imaging was used to measure the cortical activation. After four weeks of treatment, the motor functions of the affected upper limbs were significantly improved in all the patients, with the improvement in the experimental group being significantly better than in the control group. The action performance time in the WMFT significantly decreased in the experimental group. Furthermore, the activation intensity and the laterality index of the contralateral primary sensorimotor cortex increased in both the experimental and control groups. These results confirmed that Leap Motion-based virtual reality training was a promising and feasible supplementary rehabilitation intervention, could facilitate the recovery of motor functions in subacute stroke patients. The study has been registered in the Chinese Clinical Trial Registry (registration number: ChiCTR-OCH-12002238.

Study of the K+p→K+0pπ0+ reactions between 2.1 and 2.7GeV/c

International Nuclear Information System (INIS)

Brunet, J.-M.

1971-01-01

K + p→KπN reactions were studied at 2.11, 2.31, 2.53 and 2.72GeV/c, special attention being given to the K + p→K 0 π + p and K + p→K + π 0 p channels. The production of K*(892) and Δ ++ (1236) resonances, very frequent in these two reactions, was studied in terms of a simple Regge model. It was possible, by including results of other experiments at near energies, to establish the dominance of the vector meson exchange. This result is confirmed by the study of the angular distributions in the decay of these resonances, and the determination of the corresponding density matrix elements. The relations predicted by the quark model for these reactions was also tested [fr

Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health.

Science.gov (United States)

Schwalfenberg, Gerry Kurt

2017-01-01

To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. PubMed was searched for articles on vitamin K (K1 and K2) along with books and conference proceedings and health conditions listed above. Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease. Evidence is insufficient for use in diabetes, arthritis, renal calculi, and cancer. Vitamin K2 may be a useful adjunct for the treatment of osteoporosis, along with vitamin D and calcium, rivaling bisphosphonate therapy without toxicity. It may also significantly reduce morbidity and mortality in cardiovascular health by reducing vascular calcification. Vitamin K2 appears promising in the areas of diabetes, cancer, and osteoarthritis. Vitamin K use in warfarin therapy is safe and may improve INR control, although a dosage adjustment is required. Vitamin K supplementation may be useful for a number of chronic conditions that are afflicting North Americans as the population ages. Supplementation may be required for bone and cardiovascular health.

The status of Thailand Y2K Progress

International Nuclear Information System (INIS)

Srisanan, V.; Junlanan, M.; Malaivongs, K.

1999-01-01

This report divided into two parts deals with the general status of Y2K issues in Thailand and its effects in nuclear safeguards and physical protection and control of nuclear materials. It includes a description of safeguards in Thailand, Y2K action plan, contingency (emergency) plan, Thailand Y2K status report and the Thailand answer sheet about safeguards Y2K problem

Forecasting of Energy-Related CO2 Emissions in China Based on GM(1,1 and Least Squares Support Vector Machine Optimized by Modified Shuffled Frog Leaping Algorithm for Sustainability

Directory of Open Access Journals (Sweden)

Shuyu Dai

2018-03-01

Full Text Available Presently, China is the largest CO2 emitting country in the world, which accounts for 28% of the CO2 emissions globally. China’s CO2 emission reduction has a direct impact on global trends. Therefore, accurate forecasting of CO2 emissions is crucial to China’s emission reduction policy formulating and global action on climate change. In order to forecast the CO2 emissions in China accurately, considering population, the CO2 emission forecasting model using GM(1,1 (Grey Model and least squares support vector machine (LSSVM optimized by the modified shuffled frog leaping algorithm (MSFLA (MSFLA-LSSVM is put forward in this paper. First of all, considering population, per capita GDP, urbanization rate, industrial structure, energy consumption structure, energy intensity, total coal consumption, carbon emission intensity, total imports and exports and other influencing factors of CO2 emissions, the main driving factors are screened according to the sorting of grey correlation degrees to realize feature dimension reduction. Then, the GM(1,1 model is used to forecast the main influencing factors of CO2 emissions. Finally, taking the forecasting value of the CO2 emissions influencing factors as the model input, the MSFLA-LSSVM model is adopted to forecast the CO2 emissions in China from 2018 to 2025.

Cryogenic test of the 4 K / 2 K insert for the ARIEL e-Linac cryomodule

International Nuclear Information System (INIS)

Laxdal, R. E.; Ma, Y.; Harmer, P.; Kishi, D.; Koveshnikov, A.; Muller, N.; Vrielink, A.; O'Brien, M.; Ahammed, M.

2014-01-01

The ARIEL project at TRIUMF requires a 50 MeV superconducting electron linac consisting of five nine cell 1.3 GHz cavities divided into three cryomodules with one, two and two cavities in each module respectively. LHe is distributed in parallel to each module at 4 K and at ∼1.2 bar. Each module has a cryogenic insert on board that receives the 4 K liquid and produces 2 K into a cavity phase separator. The module combines a 4 K phase separator, a plate and fin heat exchanger from DATE and a J-T valve expanding into the 2 K phase separator. The unit also supplies 4 K liquid to thermal intercepts in the module in siphon loops that return the vaporized liquid to the 4 K reservoir. For testing purposes the unit is outfitted with a dummy 2 K phase separator and thermal intercepts with variable heaters that mimic the final heat loads in order to test the cryogenic performance. The design of the 4 K / 2 K insert, the results of the cold tests and a summary of the test infrastructure including cryogenics services will be presented

Cryogenic test of the 4 K / 2 K insert for the ARIEL e-Linac cryomodule

Energy Technology Data Exchange (ETDEWEB)

Laxdal, R. E.; Ma, Y.; Harmer, P.; Kishi, D.; Koveshnikov, A.; Muller, N.; Vrielink, A. [TRIUMF, 4004 Wesbrook Mall, Vancouver, BC (Canada); O' Brien, M. [University of British Columbia, Vancouver (Canada); Ahammed, M. [Variable Energy Cyclotron Center, Kolkata (India)

2014-01-29

The ARIEL project at TRIUMF requires a 50 MeV superconducting electron linac consisting of five nine cell 1.3 GHz cavities divided into three cryomodules with one, two and two cavities in each module respectively. LHe is distributed in parallel to each module at 4 K and at ∼1.2 bar. Each module has a cryogenic insert on board that receives the 4 K liquid and produces 2 K into a cavity phase separator. The module combines a 4 K phase separator, a plate and fin heat exchanger from DATE and a J-T valve expanding into the 2 K phase separator. The unit also supplies 4 K liquid to thermal intercepts in the module in siphon loops that return the vaporized liquid to the 4 K reservoir. For testing purposes the unit is outfitted with a dummy 2 K phase separator and thermal intercepts with variable heaters that mimic the final heat loads in order to test the cryogenic performance. The design of the 4 K / 2 K insert, the results of the cold tests and a summary of the test infrastructure including cryogenics services will be presented.

Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health

Directory of Open Access Journals (Sweden)

Gerry Kurt Schwalfenberg

2017-01-01

Full Text Available Objective. To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. Quality of Evidence. PubMed was searched for articles on vitamin K (K1 and K2 along with books and conference proceedings and health conditions listed above. Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease. Evidence is insufficient for use in diabetes, arthritis, renal calculi, and cancer. Main Message. Vitamin K2 may be a useful adjunct for the treatment of osteoporosis, along with vitamin D and calcium, rivaling bisphosphonate therapy without toxicity. It may also significantly reduce morbidity and mortality in cardiovascular health by reducing vascular calcification. Vitamin K2 appears promising in the areas of diabetes, cancer, and osteoarthritis. Vitamin K use in warfarin therapy is safe and may improve INR control, although a dosage adjustment is required. Conclusion. Vitamin K supplementation may be useful for a number of chronic conditions that are afflicting North Americans as the population ages. Supplementation may be required for bone and cardiovascular health.

T2K neutrino flux prediction

CERN Document Server

Abe, K.

2013-01-02

The Tokai-to-Kamioka (T2K) experiment studies neutrino oscillations using an off-axis muon neutrino beam with a peak energy of about 0.6 GeV that originates at the J-PARC accelerator facility. Interactions of the neutrinos are observed at near detectors placed at 280 m from the production target and at the far detector -- Super-Kamiokande (SK) -- located 295 km away. The flux prediction is an essential part of the successful prediction of neutrino interaction rates at the T2K detectors and is an important input to T2K neutrino oscillation and cross section measurements. A FLUKA and GEANT3 based simulation models the physical processes involved in the neutrino production, from the interaction of primary beam protons in the T2K target, to the decay of hadrons and muons that produce neutrinos. The simulation uses proton beam monitor measurements as inputs. The modeling of hadronic interactions is re-weighted using thin target hadron production data, including recent charged pion and kaon measurements from the NA...

Campaign 9 of the K2 mission

DEFF Research Database (Denmark)

Henderson, Calen B.; Poleski, Radosław; Penny, Matthew

2016-01-01

K2's Campaign 9 (K2C9) will conduct a ˜3.7 deg2 survey toward the Galactic bulge from 2016 April 22 through July 2 that will leverage the spatial separation between K2 and the Earth to facilitate measurement of the microlens parallax {π }{{E}} for ≳ 170 microlensing events. These will include....... In this article we provide an overview of the K2C9 space- and ground-based microlensing survey. Specifically, we detail the demographic questions that can be addressed by this program, including the frequency of FFPs and the Galactic distribution of exoplanets, the observational parameters of K2C9, and the array...... of resources dedicated to concurrent observations. Finally, we outline the avenues through which the larger community can become involved, and generally encourage participation in K2C9, which constitutes an important pathfinding mission and community exercise in anticipation of WFIRST....

Structure determination of K2ZnBr4 at 291 and 144 K

International Nuclear Information System (INIS)

Fabry, J.; Breczewski, T.; Zuniga, F.J.; Arnaiz, A.R.

1993-01-01

The room-temperature phase of K 2 ZnBr 4 is isomorphous with Sr 2 GeS 4 (P2 1 /m) while the low-temperature structure (P2 1 ) is slightly distorted [the phase transition occurs at 155 K]. Both structures contain highly deformed tetrahedral [ZnBr 4 ] 2- molecules with Br(3)-Zn-Br(3') angles of 103.06(5) and 102.49(9) at 291 and 144 K, respectively. This distortion is caused by the repulsion of Br atoms whose distance 3.712(1) and 3.661(2) A at 291 and 144 K, respectively, is below the Br-Br van der Waals distance (3.9 A). The phase transition is accompanied by minor shifts of cations and [ZnBr 4 ] 2- tetrahedra which are simultaneously rotated about a small angle. Below the phase transition point an inversion twin develops whose twin-fraction parameter was refined to 0.459(65). (orig.)

Ultrasound assessment of great saphenous vein insufficiency

Directory of Open Access Journals (Sweden)

Chander RK

2015-06-01

Full Text Available Rajiv K Chander,1 Thomas S Monahan1,2 1Section of Vascular Surgery, Department of Surgery, University of Maryland School of Medicine, 2Department of Surgery, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA Abstract: Duplex ultrasonography is the ideal modality to assess great saphenous vein insufficiency. Duplex ultrasonography incorporates both gray scale images to delineate anatomy and color-Doppler imaging that visualizes the flow of blood in a structure. Assessment of great saphenous vein requires definition of the anatomy, augmentation of flow, evaluation for both superficial and deep vein thrombosis, and determining the presence of reflux. Currently, evolution in the treatment of reflux also relies on ultrasound for the treatment of the disease. Understanding the utilization of the ultrasound for the diagnosis and treatment of greater saphenous vein reflux is important for practitioners treating reflux disease. Keywords: duplex ultrasonography, small saphenous vein 

UNION-K 2.0 User's Manual

International Nuclear Information System (INIS)

Yoo, Jae Woon; Jang, Jin Wook; Kim, Yeong Il

2008-12-01

The unified Input/Output processor UNION-K(UNified Input/Output Processor for Neutronics Analysis by K-CORE) has been developed to provide the automatic input file generation and output processing for the fast reactor core analysis. UNION-K includes the material database for reactor analysis and produces the input files for effective cross section generation, core analysis, and reactivity coefficient calculations. UNION-K can execute corresponding core analysis module and edit core performance parameters from the outputs. UNION-K also provides the graphical interface to check the geometrical arrangement of core and fuel sub-assembly and produces the picture files that can be used for reporting. This report has been prepared for instruction of using UNION-K Ver. 2.0 with examples

TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions

Directory of Open Access Journals (Sweden)

Luis Pablo Cid

2013-07-01

Full Text Available TASK-2 (K2P5.1 is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinisation. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectivity filter and inner gates respectively. TASK-2 is modulated by changes in cell volume and a regulation by direct G-protein interaction has also been proposed. Activation by extracellular alkalinisation has been associated with a role of TASK-2 in kidney proximal tubule bicarbonate reabsorption, whilst intracellular pH-sensitivity might be the mechanism for its participation in central chemosensitive neurons. In addition to these functions TASK-2 has been proposed to play a part in apoptotic volume decrease in kidney cells and in volume regulation of glial cells and T-lymphocytes. TASK-2 is present in chondrocytes of hyaline cartilage, where it is proposed to play a central role in stabilizing the membrane potential. Additional sites of expression are dorsal root ganglion neurons, endocrine and exocrine pancreas and intestinal smooth muscle cells. TASK-2 has been associated with the regulation of proliferation of breast cancer cells and could become target for breast cancer therapeutics. Further work in native tissues and cells together with genetic modification will no doubt reveal the details of TASK-2 functions that we are only starting to suspect.

K2-EDTA and K3-EDTA Greiner Tubes for HbA1c Measurement.

Science.gov (United States)

Vrtaric, Alen; Filipi, Petra; Hemar, Marina; Nikolac, Nora; Simundic, Ana-Maria

2016-02-01

To determine whether K2-ethylenediaminetetraacetic acid (EDTA) and K3-EDTA Greiner tubes could be used interchangeably for glycosylated hemoglobin, type A1C (HbA1c) measurement via the Abbott Laboratories ARCHITECT chemiluminescent microparticle HbA1c assay on the ARCHITECT i2000SR immunoanalyzer at our university hospital. We drew blood from a total of 45 outpatients into plastic Greiner Vacuette tubes, some of which were lined with K2-EDTA and others with K3-EDTA anticoagulant. Data are presented as median and interquartile range values. We used the Wilcoxon test and Passing-Bablok regression for tube comparison. For K2-EDTA tubes median HbA1c concentration was 54 mmol/mol (41 to 71 mmol/mol) and for K3-EDTA tubes 56 mmol/mol (43 to 69 mmol/mol). There was no statistically significant difference between K2-EDTA and K3-EDTA (bias= -1.29 mmol/mol; P = 0.24). Passing-Bablok regression showed that there is no constant and proportional error: y = -0.23 (95% CI[-3.52 to 0.69]) + 1.00( 95% CI[0.98 to 1.06]) x. In this study, we provide evidence for the lack of any clinically and statistically significant bias between K2-EDTA and K3-EDTA HbA1c measurements. Thus, Greiner tubes lined with K2-EDTA and those lined with K3-EDTA can safely be used interchangeably to measure HbA1c via the Abbott Laboratories ARCHITECT assay. © American Society for Clinical Pathology, 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Aggregation in organic light emitting diodes

Science.gov (United States)

Meyer, Abigail

Organic light emitting diode (OLED) technology has great potential for becoming a solid state lighting source. However, there are inefficiencies in OLED devices that need to be understood. Since these inefficiencies occur on a nanometer scale there is a need for structural data on this length scale in three dimensions which has been unattainable until now. Local Electron Atom Probe (LEAP), a specific implementation of Atom Probe Tomography (APT), is used in this work to acquire morphology data in three dimensions on a nanometer scale with much better chemical resolution than is previously seen. Before analyzing LEAP data, simulations were used to investigate how detector efficiency, sample size and cluster size affect data analysis which is done using radial distribution functions (RDFs). Data is reconstructed using the LEAP software which provides mass and position data. Two samples were then analyzed, 3% DCM2 in C60 and 2% DCM2 in Alq3. Analysis of both samples indicated little to no clustering was present in this system.

A calorimetric and thermodynamic investigation of A2[(UO2)2(MoO4)O2] compounds with A = K and Rb and calculated phase relations in the system (K2MoO4 + UO3 + H2O)

International Nuclear Information System (INIS)

Lelet, Maxim I.; Suleimanov, Evgeny V.; Golubev, Aleksey V.; Geiger, Charles A.; Bosbach, Dirk; Alekseev, Evgeny V.

2015-01-01

Highlights: • We determined the low temperature heat capacity of A 2 [(UO 2 ) 2 (MoO 4 )O 2 ] compounds with A = K and Rb. • We determined enthalpy of formation of K 2 [(UO 2 ) 2 (MoO 4 )O 2 ] by HF solution calorimetry. • We calculated Δ f G° (T = 298 K) of all phases from studied series. • Using obtained data we performed a thermodynamic modelling in the system (K 2 MoO 4 + UO 3 + H 2 O). - Abstract: A calorimetric and thermodynamic investigation of two alkali-metal uranyl molybdates with general composition A 2 [(UO 2 ) 2 (MoO 4 )O 2 ], where A = K and Rb, was performed. Both phases were synthesized by solid-state sintering of a mixture of potassium or rubidium nitrate, molybdenum (VI) oxide and gamma-uranium (VI) oxide at high temperatures. The synthetic products were characterised by X-ray powder diffraction and X-ray fluorescence methods. The enthalpy of formation of K 2 [(UO 2 ) 2 (MoO 4 )O 2 ] was determined using HF-solution calorimetry giving Δ f H° (T = 298 K, K 2 [(UO 2 ) 2 (MoO 4 )O 2 ], cr) = −(4018 ± 8) kJ · mol −1 . The low-temperature heat capacity, C p °, was measured using adiabatic calorimetry from T = (7 to 335) K for K 2 [(UO 2 ) 2 (MoO 4 )O 2 ] and from T = (7 to 326) K for Rb 2 [(UO 2 ) 2 (MoO 4 )O 2 ]. Using these C p ° values, the third law entropy at T = 298.15 K, S°, is calculated as (374 ± 1) J · K −1 · mol −1 for K 2 [(UO 2 ) 2 (MoO 4 )O 2 ] and (390 ± 1) J · K −1 · mol −1 for Rb 2 [(UO 2 ) 2 (MoO 4 )O 2 ]. These new experimental results, together with literature data, are used to calculate the Gibbs energy of formation, Δ f G°, for both phases giving: Δ f G° (T = 298 K, K 2 [(UO 2 ) 2 (MoO 4 )O 2 ], cr) = (−3747 ± 8) kJ · mol −1 and Δ f G° (T = 298 K, Rb 2 [(UO 2 ) 2 (MoO 4 )], cr) = −3736 ± 5 kJ · mol −1 . Smoothed C p °(T) values between 0 K and 320 K are presented, along with values for S° and the functions [H°(T) − H°(0)] and [G°(T) − H°(0)], for both phases. The

Sustainable Building in China—A Green Leap Forward?

Directory of Open Access Journals (Sweden)

Jialiang Wang

2013-09-01

Full Text Available China is constructing new commercial buildings at an enormous rate—roughly 2 billion square meters per year, with considerable interest and activity in green design and construction. We review the context of commercial building design and construction in China, and look at a specific project as an example of a high performance, sustainable design, the Shenzhen Institute of Building Research (IBR. The IBR building incorporates over 40 sustainable technologies and strategies, including daylighting, natural ventilation, gray-water recycling, solar-energy generation, and highly efficient Heating Ventilation and Air Conditioning (HVAC systems. We present measured data on the performance of the building, including detailed analysis by energy end use, water use, and occupant comfort and satisfaction. Total building energy consumption in 2011 was 1151 MWh, with an Energy Use Intensity (EUI of 63 kWh/m2 (20 kBtu/ft2, which is 61% of the mean EUI value of 103 kWh/m2 (33 kBtu/ft2 for similar buildings in the region. We also comment on the unique design process, which incorporated passive strategies throughout the building, and has led to high occupant satisfaction with the natural ventilation, daylighting, and green patio work areas. Lastly we present thoughts on how the design philosophy of the IBR building can be a guide for low-energy design in different climate regions throughout China and elsewhere.

Effect of vitamin K2 on type 2 diabetes mellitus: A review.

Science.gov (United States)

Li, Yan; Chen, Jie Peng; Duan, Lili; Li, Shuzhuang

2018-02-01

Type 2 diabetes mellitus (T2DM) continue to be a major public health problem around the world that frequently presents with microvascular and macrovascular complications. Individuals with T2DM are not only suffering from significant emotional and physical misery, but also at increased risk of dying from severe complications. In recent years, evidence from prospective observational studies and clinical trials has shown T2DM risk reduction with vitamin K2 supplementation. We thus did an overview of currently available studies to assess the effect of vitamin K2 supplementation on insulin sensitivity, glycaemic control and reviewed the underlying mechanisms. We proposed that vitamin K2 improved insulin sensitivity through involvement of vitamin K-dependent-protein osteocalcin, anti-inflammatory properties, and lipid-lowering effects. Vitamin K2 had a better effect than vitamin K1 on T2DM. The interpretation of this review will increase comprehension of the development of a therapeutic strategy to prevent and treat T2DM. Copyright © 2017 Elsevier B.V. All rights reserved.

On two-primary algebraic K-theory of quadratic number rings with focus on K_2

NARCIS (Netherlands)

Crainic, M.; Østvær, Paul Arne

1999-01-01

We give explicit formulas for the 2-rank of the algebraic K-groups of quadratic number rings. A 4-rank formula for K2 of quadratic number rings given in [1] provides further information about the actual group structure. The K2 claculations are based on 2- and 4-rank formulas for Picard groups of

Binding of the heterogeneous ribonucleoprotein K (hnRNP K to the Epstein-Barr virus nuclear antigen 2 (EBNA2 enhances viral LMP2A expression.

Directory of Open Access Journals (Sweden)

Henrik Gross

Full Text Available The Epstein-Barr Virus (EBV -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs. Its Arginine-Glycine (RG repeat element contains either symmetrically or asymmetrically di-methylated arginine residues (SDMA and ADMA, respectively. EBNA2 binds via its SDMA-modified RG-repeat to the survival motor neurons protein (SMN and via the ADMA-RG-repeat to the NP9 protein of the human endogenous retrovirus K (HERV-K (HML-2 Type 1. The hypothesis of this work was that the methylated RG-repeat mimics an epitope shared with cellular proteins that is used for interaction with target structures. With monoclonal antibodies against the modified RG-repeat, we indeed identified cellular homologues that apparently have the same surface structure as methylated EBNA2. With the SDMA-specific antibodies, we precipitated the Sm protein D3 (SmD3 which, like EBNA2, binds via its SDMA-modified RG-repeat to SMN. With the ADMA-specific antibodies, we precipitated the heterogeneous ribonucleoprotein K (hnRNP K. Specific binding of the ADMA- antibody to hnRNP K was demonstrated using E. coli expressed/ADMA-methylated hnRNP K. In addition, we show that EBNA2 and hnRNP K form a complex in EBV- infected B-cells. Finally, hnRNP K, when co-expressed with EBNA2, strongly enhances viral latent membrane protein 2A (LMP2A expression by an unknown mechanism as we did not detect a direct association of hnRNP K with DNA-bound EBNA2 in gel shift experiments. Our data support the notion that the methylated surface of EBNA2 mimics the surface structure of cellular proteins to interfere with or co-opt their functional properties.

A New Method Based On Modified Shuffled Frog Leaping Algorithm In Order To Solve Nonlinear Large Scale Problem

Directory of Open Access Journals (Sweden)

Aliasghar Baziar

2015-03-01

Full Text Available Abstract In order to handle large scale problems this study has used shuffled frog leaping algorithm. This algorithm is an optimization method based on natural memetics that uses a new two-phase modification to it to have a better search in the problem space. The suggested algorithm is evaluated by comparing to some well known algorithms using several benchmark optimization problems. The simulation results have clearly shown the superiority of this algorithm over other well-known methods in the area.

Cluster self-organization of germanate systems: suprapolyhedral precursor clusters and self-assembly of K2Nd4Ge4O13(OH)4, K2YbGe4O10(OH), K2Sc2Ge2O7(OH)2, and KScGe2O6(PYR)

International Nuclear Information System (INIS)

Ilyushin, G.D.; Dem'yanets, L.N.

2008-01-01

One performed the computerized (the TOPOS 4.0 software package) geometric and topological analyses of all known types of K, TR-germanates (TR = La-Lu, Y, Sc, In). The skeleton structure are shown as three-dimensional 3D, K, TR, Ge-patterns (graphs) with remote oxygen atoms. TR 4 3 3 4 3 3 + T 4 3 4 3, K 2 YbGe 4 O 14 (OH) pattern, TR 6 6 3 6 + T1 6 8 6 + T2 3 6 8, K 2 Sc 2 Ge 2 O 7 (OH) 2 , TR 6 4 6 4 + T 6 4 6 and KScGe 2 O 6 - TR 6 6 3 6 3 4 + T1 6 3 6 + T2 6 4 3 patterns served as crystal-forming 2D TR,Ge-patterns for K 2 Nd 4 Ge 4 O 13 (OH) 4 . One performed the 3D-simulation of the mechanism of self-arrangement of the crystalline structures: cluster-precursor - parent chain - microlayer - microskeleton (super-precursor). Within K 2 Nd 4 Ge 4 O 13 (OH) 4 , K 2 Sc 2 Ge 2 O 7 (OH) 2 and KScGe 2 O 6 one identified the invariant type of the cyclic hexapolyhedral cluster-precursor consisting of TR-octahedrons linked by diorthogroups stabilized by K atoms. For K 2 Nd 4 Ge 4 O 13 (OH) 4 one determined the type of the cyclic tetrapolyhedral cluster-precursor consisting of TR-octavertices linked by tetrahedrons. The cluster CN within the layer just for KScGe 2 O 6 water-free germanate (the PYR pyroxene analog) is equal to 6 (the maximum possible value), while in the rest OH-containing germanates it constitutes 4. One studied the formation mechanism of Ge-radicals in the form of Ge 2 O 7 and Ge 4 O 13 groupings, GeO 3 chain and the tubular structure consisting of Ge 8 O 20 fixed cyclic groupings [ru

2D-grafiikan käyttö peliprojektissa

OpenAIRE

Reimi-Orsa, Anniina

2010-01-01

Opinnäytetyö on projektikuvaus, jossa on käsitelty kaksiulotteisen grafiikan käyttöä peliprojektissa toteutettujen töiden kautta. Työharjoittelussani tuotin materiaalia peliprojektiin, jonka maailma luotiin pääasiassa 2D-grafiikan avulla. Projektikuvauksessa on käyty läpi työn kulkua alkuvalmisteluista valmiiseen pelissä käytettävään grafiikkaan sekä käytäntöjä tämän tyyppisen 2D-grafiikan tuotannossa. Alussa peliprojektia on käsitelty yleisluontoisesti sekä avattu työssä käytettyjä ja p...

Do invasive quagga mussels alter CO2 dynamics in the Laurentian Great Lakes?

Science.gov (United States)

Lin, Peng; Guo, Laodong

2016-12-01

The Laurentian Great Lakes have experienced unprecedented ecological and environmental changes, especially after the introduction of invasive quagga mussel (Dreissena rostriformis bugensis). While impacts on ecological functions have been widely recognized, the response of carbon dynamics to invasive species remains largely unknown. We report new CO2 data showing significant increases in pCO2 (up to 800 μatm in Lake Michigan) and CO2 emission fluxes in most of the Great Lakes compared to those prior to or during the early stage of the colonization of invasive quagga mussels. The increased CO2 supersaturation is most prominent in Lakes Huron and Michigan, followed by Lakes Ontario and Erie, but no evident change was observed in Lake Superior. This trend mirrors the infestation extent of invasive quagga mussels in the Great Lakes and is consistent with the decline in primary production and increase in water clarity observed pre- and post-Dreissena introduction, revealing a close linkage between invasive species and carbon dynamics. The Great Lakes have become a significant CO2 source to the atmosphere, emitting >7.7 ± 1.0 Tg-C annually, which is higher than the organic carbon burial rate in global inland-seas and attesting to the significant role of the Laurentian Great Lakes in regional/global CO2 budget and cycling.

Physical and chemical properties of MgO ceramics treated in molten K2SO4 for a long period

International Nuclear Information System (INIS)

Iwasa, Mikio; Kose, Saburo; Korenaga, Sadayoshi; Furukawa, Mitsuhiko.

1978-01-01

The wall materials of MHD power generating channel are exposed to thermally, physically and chemically severe conditions, so that they have to withstand great damages, especially the attack of seed materials. Several kinds of ceramics proposed as the wall materials have been tested in the simulated MHD environment. In this paper, MgO ceramics were treated in molten K 2 SO 4 , a typical seed material, and the changes in their physical and chemical properties were investigated in comparison with those of Al 2 O 3 ceramics. four kinds of MgO ceramics, three sintered and one electric fused, were immersed in molten K 2 SO 4 at 1300 0 C for the periods up to 1000 h, and weight, volume, surface roughness, bending strength and hardness were measured. The changes in the microstructures and chemical compositions due to the K 2 SO 4 treatment were also investigated. MgO ceramics were attacked by molten K 2 SO 4 only at the grain boundaries on the surface, in contrast at Al 2 O 3 ceramics which were severely damaged to form β-Al 2 O 3 . It was found that SiO 2 and CaO in the grain boundaries had played important roles to the attack of K 2 SO 4 . Generally, the changes in the properties of MgO ceramics by the K 2 SO 4 treatment were very small compared with those of Al 2 O 3 ceramics. It was concluded that MgO ceramics are more stable than Al 2 O 3 ceramics in molten K 2 SO 4 and their properties do not show substantial drops for long periods. (author)

Giant strain with low cycling degradation in Ta-doped [Bi{sub 1/2}(Na{sub 0.8}K{sub 0.2}){sub 1/2}]TiO{sub 3} lead-free ceramics

Energy Technology Data Exchange (ETDEWEB)

Liu, Xiaoming; Tan, Xiaoli, E-mail: xtan@iastate.edu [Department of Materials Science and Engineering, Iowa State University, Ames, Iowa 50011 (United States)

2016-07-21

Non-textured polycrystalline [Bi{sub 1/2}(Na{sub 0.8}K{sub 0.2}){sub 1/2}](Ti{sub 1−x}Ta{sub x})O{sub 3} ceramics are fabricated and their microstructures and electrical properties are characterized. Transmission electron microscopy reveals the coexistence of the rhombohedral R3c and tetragonal P4bm phases in the form of nanometer-sized domains in [Bi{sub 1/2}(Na{sub 0.8}K{sub 0.2}){sub 1/2}]TiO{sub 3} with low Ta concentration. When the composition is x = 0.015, the electrostrain is found to be highly asymmetric under bipolar fields of ±50 kV/cm. A very large value of 0.62% is observed in this ceramic, corresponding to a large-signal piezoelectric coefficient d{sub 33}* of 1240 pm/V (1120 pm/V under unipolar loading). These values are greater than most previously reported lead-free polycrystalline ceramics and can even be compared with some lead-free piezoelectric single crystals. Additionally, this ceramic displays low cycling degradation; its electrostrain remains above 0.55% even after undergoing 10 000 cycles of ±50 kV/cm bipolar fields at 2 Hz. Therefore, Ta-doped [Bi{sub 1/2}(Na{sub 0.8}K{sub 0.2}){sub 1/2}]TiO{sub 3} ceramics show great potential for large displacement devices.

Study on the thermoluminescent properties of K{sub 2}YF{sub 5} and K{sub 2}GdF{sub 5} crystals doped with optically active trivalent ions for gamma and neutrons dosimetry; Estudo das propriedades termoluminescentes de cristais de K{sub 2}YF{sub 5} e K{sub 2}GdF{sub 5} dopados com ions trivalentes opticamente ativos para dosimetria gama e de neutrons

Energy Technology Data Exchange (ETDEWEB)

Silva, Edna Carla da

2008-07-01

In this work, the thermoluminescent (TL) properties of both double potassium yttrium fluoride (K{sub 2}YF{sub 5}) and double potassium gadolinium fluoride (K{sub 2}GdF{sub 5}) crystals doped with optically active rare earth ions were investigated from the point of view of gamma and neutron dosimetry. Crystalline platelets with thickness of about 1 mm, synthesized under hydrothermal conditions, were irradiated in order to study TL sensitivity, as well as dose and energy response, reproducibility and fading, in terms of Ce{sup 3+}, Tb{sup 3+}, Dy{sup 3+}, e Pr{sup 3+} concentrations. The K{sub 2}YF{sub 5} crystals doped with 1.0 at por cent Dy{sup 3+} have been found to have an excellent linear TL response to X and gamma photons, in the range of 0.01 to 10 mGy. The TL output is comparable to that of CaS0{sub 4}:Mn dosemeters. The main peak at 130 deg C has been found to have a TL response for 41.1 keV X-ray energy 32 times higher than that for 662 keV gamma rays. This fact points out that the K{sub 2}Y{sub 0.99}Dy{sub 0.01}F{sub 5} crystals have great potential for X-rays diagnostic and/or industrial radiography. On the other hand, the K{sub 2}GdF{sub 5} crystals doped with 5.0 at por cent Dy{sup 3+} have been found to have the better TL response for gamma and fast neutron radiation, among the dopants studied. For gamma fields the TL response was linear for doses ranging from 0.1 to 200 mGy. The TL peak around 200 deg C can be deconvoluted into four individual peaks, all of them with linear behavior. For fast neutron radiation produced by an {sup 241}Am{sub B}e source, the TL responses for doses ranging from 0.6 to 12 mSv were also linear and comparable to that of commercial TLD-600, irradiated at same conditions. The TL emission due to neutrons was in the high temperature range, above 200 deg C. These results points out that K{sub 2}Gd{sub 0.95}Dy{sub 0.05}F{sub 5} crystals are good candidates for use in neutron dosimetry applications. (author)

Vibrational modes and Structure of Niobium(V) Oxosulfato Complexes in the Molten Nb2O5-K2S2O7-K2SO4 System Studied by Raman Spectroscopy

DEFF Research Database (Denmark)

Paulsen, Andreas L.; Borup, Flemming; Berg, Rolf W.

2010-01-01

The structural and vibrational properties of NbV oxosulfato complexes formed in Nb2O5-K2S2O7 and Nb2O5-K2S2O7-K2SO4 molten mixtures with 0 ... for the binary Nb2O5-K2S2O7 molten system indicate that the dissolution of Nb2O5 proceeds with consumption of S2O7 leading to the formation of a NbV oxosulfato complex according to Nb2O5 + nS2O7 --> C2n-; a simple formalism exploiting the relative Raman band intensities is used for determining the stoichiometric...... coefficient, n, pointing to n = 3 and to the following reaction: Nb2O5 + 3S2O7 --> 2NbO(SO4)3, which is consistent with the Raman spectra of the molten mixtures. Nb2O5 could be dissolved much easier when K2SO4 was present in an equimolar (1:1) SO4/Nb ratio; the incremental presence of K2SO4 in Nb2O5-K2S2O7...

Are You Ready for Y2K?

Science.gov (United States)

Day, C. William

1999-01-01

Examines the planning process to identify equipment or systems within an educational facility that could be Y2K sensitive. Discusses developing a contingency plan to prevent operational shutdown. Concluding comments describe a simple Y2K equipment-testing procedure. (GR)

Defects in SiO2 crystals after neutron irradiations at 20 K and 360 K

International Nuclear Information System (INIS)

Nakagawa, M.; Okada, M.; Kawabata, Y.; Atobe, K.; Itoh, H.; Nakanishi, S.

1994-01-01

The synthetic silicon dioxide (SiO 2 ), cut parallel (x-plate) or perpendicular (z-plate) to c-axis, are irradiated by reactor neutrons at 360 K (2.8x10 18 n/cm 2 ) or at 20 K (8.0x10 16 n/cm 2 ). After neutron irradiation at 360 K, the main absorption peak can be observed at 212 nm (5.84 eV) for z-plate and 217 nm (5.71 eV) for x-plate. After irradiation at 20 K a new band at 250 nm (4.96 eV) can be observed in addition to the band at about 220 nm. The 250 nm band having FWHM similar 0.44 eV disappears at 300-340 K. Thermoluminescences are also observed between 80 to 400 K; which show some difference between x-plate and z-plate. ((orig.))

26 CFR 1.401(k)-2 - ADP test.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 5 2010-04-01 2010-04-01 false ADP test. 1.401(k)-2 Section 1.401(k)-2 Internal... TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.401(k)-2 ADP test. (a) Actual deferral percentage (ADP) test—(1) In general—(i) ADP test formula. A cash or deferred arrangement satisfies the ADP...

Decreased triadin and increased calstabin2 expression in Great Danes with dilated cardiomyopathy.

Science.gov (United States)

Oyama, M A; Chittur, S V; Reynolds, C A

2009-01-01

Dilated cardiomyopathy (DCM) is a common cardiac disease of Great Dane dogs, yet very little is known about the underlying molecular abnormalities that contribute to disease. Discover a set of genes that are differentially expressed in Great Dane dogs with DCM as a way to identify candidate genes for further study as well as to better understand the molecular abnormalities that underlie the disease. Three Great Dane dogs with end-stage DCM and 3 large breed control dogs. Prospective study. Transcriptional activity of 42,869 canine DNA sequences was determined with a canine-specific oligonucleotide microarray. Genome expression patterns of left ventricular tissue samples from affected Great Dane dogs were evaluated by measuring the relative amount of complementary RNA hybridization to the microarray probes and comparing it with expression from large breed dogs with noncardiac disease. Three hundred and twenty-three transcripts were differentially expressed (> or = 2-fold change). The transcript with the greatest degree of upregulation (+61.3-fold) was calstabin2 (FKBP12.6), whereas the transcript with the greatest degree of downregulation (-9.07-fold) was triadin. Calstabin2 and triadin are both regulatory components of the cardiac ryanodine receptor (RyR2) and are critical to normal intracellular Ca2+ release and excitation-contraction coupling. Great Dane dogs with DCM demonstrate abnormal calstabin2 and triadin expression. These changes likely affect Ca2+ flux within cardiac cells and may contribute to the pathophysiology of disease. Microarray-based analysis identifies calstabin2, triadin, and RyR2 function as targets of future study.

Sustainable Building in China -- A Green Leap Forward?

Energy Technology Data Exchange (ETDEWEB)

Diamond, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ye, Qing [Shenzhen Inst. of Building Research (China); Feng, Wei [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yan, Tao [Shenzhen Inst. of Building Research (China); Mao, Hongwei [Shenzhen Inst. of Building Research (China); Li, Yutong [Shenzhen Inst. of Building Research (China); Guo, Yongcong [Shenzhen Inst. of Building Research (China); Wang, Jialiang [Shenzhen Inst. of Building Research (China)

2013-09-01

China is constructing new commercial buildings at an enormous rate -- roughly 2 billion square meters per year, with considerable interest and activity in green design and construction. We review the context of commercial building design and construction in China, and look at a specific project as an example of a high performance, sustainable design, the Shenzhen Institute of Building Research (IBR). The IBR building incorporates over 40 sustainable technologies and strategies, including daylighting, natural ventilation, gray-water recycling, solar-energy generation, and highly efficient Heating Ventilation and Air Conditioning (HVAC) systems. We present measured data on the performance of the building, including detailed analysis by energy end use, water use, and occupant comfort and satisfaction. Total building energy consumption in 2011 was 1151 MWh, with an Energy Use Intensity (EUI) of 63 kWh/m² (20 kBtu/ft²), which is 61% of the mean EUI value of 103 kWh/m² (33 kBtu/ft²) for similar buildings in the region. We also comment on the unique design process, which incorporated passive strategies throughout the building, and has led to high occupant satisfaction with the natural ventilation, daylighting, and green patio work areas. Lastly we present thoughts on how the design philosophy of the IBR building can be a guide for low-energy design in different climate regions throughout China and elsewhere.

Medium- and Long-term Prediction of LOD Change with the Leap-step Autoregressive Model

Science.gov (United States)

Liu, Q. B.; Wang, Q. J.; Lei, M. F.

2015-09-01

It is known that the accuracies of medium- and long-term prediction of changes of length of day (LOD) based on the combined least-square and autoregressive (LS+AR) decrease gradually. The leap-step autoregressive (LSAR) model is more accurate and stable in medium- and long-term prediction, therefore it is used to forecast the LOD changes in this work. Then the LOD series from EOP 08 C04 provided by IERS (International Earth Rotation and Reference Systems Service) is used to compare the effectiveness of the LSAR and traditional AR methods. The predicted series resulted from the two models show that the prediction accuracy with the LSAR model is better than that from AR model in medium- and long-term prediction.

The leap from ROI to SROI: Farther than expected?

Science.gov (United States)

Gargani, John

2017-10-01

Social return on investment (SROI) is a popular method for evaluating the impact that organizations have on society and the environment. It has its roots in finance, where return on investment (ROI) is used to evaluate investments. Over the past ten years, SROI has made the leap from a tool for building private wealth to one that advances the public good. Has it landed us in a better place? To answer the question, I describe the general approach to financial analysis, how it is applied to financial decisions, and how it has been adapted to evaluate impact. I then consider the strengths and weaknesses of SROI, and suggest how, by pushing beyond the constraints of financial analysis, it can give stakeholders voice and provide evidence of success from diverse perspectives. Along the way, I propose a conceptual model for value, a foundational concept in SROI that has been criticized by some as underdeveloped, and I include a technical appendix that identifies potential sources of statistical bias in SROI estimates. I conclude by acknowledging our growing need to incorporate efficiency as one of multiple success criteria and the role that SROI-properly implemented-can play. Copyright © 2017 Elsevier Ltd. All rights reserved.

An Analysis of the Precision and Reliability of the Leap Motion Sensor and Its Suitability for Static and Dynamic Tracking

Directory of Open Access Journals (Sweden)

Jože Guna

2014-02-01

Full Text Available We present the results of an evaluation of the performance of the Leap Motion Controller with the aid of a professional, high-precision, fast motion tracking system. A set of static and dynamic measurements was performed with different numbers of tracking objects and configurations. For the static measurements, a plastic arm model simulating a human arm was used. A set of 37 reference locations was selected to cover the controller’s sensory space. For the dynamic measurements, a special V-shaped tool, consisting of two tracking objects maintaining a constant distance between them, was created to simulate two human fingers. In the static scenario, the standard deviation was less than 0.5 mm. The linear correlation revealed a significant increase in the standard deviation when moving away from the controller. The results of the dynamic scenario revealed the inconsistent performance of the controller, with a significant drop in accuracy for samples taken more than 250 mm above the controller’s surface. The Leap Motion Controller undoubtedly represents a revolutionary input device for gesture-based human-computer interaction; however, due to its rather limited sensory space and inconsistent sampling frequency, in its current configuration it cannot currently be used as a professional tracking system.

An analysis of the precision and reliability of the leap motion sensor and its suitability for static and dynamic tracking.

Science.gov (United States)

Guna, Jože; Jakus, Grega; Pogačnik, Matevž; Tomažič, Sašo; Sodnik, Jaka

2014-02-21

We present the results of an evaluation of the performance of the Leap Motion Controller with the aid of a professional, high-precision, fast motion tracking system. A set of static and dynamic measurements was performed with different numbers of tracking objects and configurations. For the static measurements, a plastic arm model simulating a human arm was used. A set of 37 reference locations was selected to cover the controller's sensory space. For the dynamic measurements, a special V-shaped tool, consisting of two tracking objects maintaining a constant distance between them, was created to simulate two human fingers. In the static scenario, the standard deviation was less than 0.5 mm. The linear correlation revealed a significant increase in the standard deviation when moving away from the controller. The results of the dynamic scenario revealed the inconsistent performance of the controller, with a significant drop in accuracy for samples taken more than 250 mm above the controller's surface. The Leap Motion Controller undoubtedly represents a revolutionary input device for gesture-based human-computer interaction; however, due to its rather limited sensory space and inconsistent sampling frequency, in its current configuration it cannot currently be used as a professional tracking system.

Comparative genome analysis of novel Podoviruses lytic for hypermucoviscous Klebsiella pneumoniae of K1, K2, and K57 capsular types.

Science.gov (United States)

Solovieva, Ekaterina V; Myakinina, Vera P; Kislichkina, Angelina A; Krasilnikova, Valentina M; Verevkin, Vladimir V; Mochalov, Vladimir V; Lev, Anastasia I; Fursova, Nadezhda K; Volozhantsev, Nikolay V

2018-01-02

Hypermucoviscous (HV) strains of capsular types K1, K2 and K57 are the most virulent representatives of the Klebsiella pneumoniae species. Eight novel bacteriophages lytic for HV K. pneumoniae were isolated and characterized. Three bacteriophages, KpV41, KpV475, and KpV71 were found to have a lytic activity against mainly K. pneumoniae of capsular type K1. Two phages, KpV74, and KpV763 were lytic for K2 capsular type K. pneumoniae, and the phage KpV767 was specific to K57-type K. pneumoniae only. Two more phages, KpV766, and KpV48 had no capsular specificity. The phage genomes consist of a linear double-stranded DNA of 40,395-44,623bp including direct terminal repeats of 180-246 bp. The G + C contents are 52.3-54.2 % that is slightly lower than that of genomes of K. pneumoniae strains being used for phage propagation. According to the genome structures, sequence similarity and phylogenetic data, the phages are classified within the genus Kp32virus and Kp34virus of subfamily Autographivirinae, family Podoviridae. In the phage genomes, genes encoding proteins with putative motifs of polysaccharide depolymerase were identified. Depolymerase genes of phages KpV71 and KpV74 lytic for hypermucoviscous K. pneumoniae of K1 and K2 capsular type, respectively, were cloned and expressed in Escherichia coli, and the recombinant gene products were purified. The specificity and polysaccharide-degrading activity of the recombinant depolymerases were demonstrated. Copyright © 2017 Elsevier B.V. All rights reserved.

Ca2+-dependent K+ Channels in Exocrine Salivary Glands

Science.gov (United States)

Catalán, Marcelo A.; Peña-Munzenmayer, Gaspar; Melvin, James E.

2014-01-01

In the last 15 years, remarkable progress has been realized in identifying the genes that encode the ion-transporting proteins involved in exocrine gland function, including salivary glands. Among these proteins, Ca2+-dependent K+ channels take part in key functions including membrane potential regulation, fluid movement and K+ secretion in exocrine glands. Two K+ channels have been identified in exocrine salivary glands: 1) a Ca2+-activated K+ channel of intermediate single channel conductance encoded by the KCNN4 gene; and, 2) a voltage- and Ca2+-dependent K+ channel of large single channel conductance encoded by the KCNMA1 gene. This review focuses on the physiological roles of Ca2+-dependent K+ channels in exocrine salivary glands. We also discuss interesting recent findings on the regulation of Ca2+-dependent K+ channels by protein-protein interactions that may significantly impact exocrine gland physiology. PMID:24559652

Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells.

Science.gov (United States)

Ogawa, Mutsumi; Nakai, Seiji; Deguchi, Akihiro; Nonomura, Takako; Masaki, Tsutomu; Uchida, Naohito; Yoshiji, Hitoshi; Kuriyama, Shigeki

2007-08-01

Although a number of studies have shown that vitamin K possesses antitumor activities on various neoplastic cell lines, there are few reports demonstrating in vivo antitumor effects of vitamin K, and the antitumor effect on colorectal cancer (CRC) remains to be examined. Therefore, antitumor effects of vitamin K on CRC were examined both in vitro and in vivo. Vitamins K2, K3 and K5 suppressed the proliferation of colon 26 cells in a dose-dependent manner, while vitamin K1 did not. On flow cytometry, induction of apoptosis by vitamins K2, K3 and K5 was suggested by population in sub-G1 phase of the cell cycle. Hoechst 33342 staining and a two-color flow cytometric assay using fluorescein isothiocyanate-conjugated annexin V and propidium iodide confirmed that vitamins K2, K3 and K5 induced apoptotic death of colon 26 cells. Enzymatic activity of caspase-3 in colon 26 cells was significantly up-regulated by vitamins K2, K3 and K5. The pan-caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone, substantially prevented vitamin K-mediated apoptosis. In vivo study using syngeneic mice with subcutaneously established colon 26 tumors demonstrated that intravenous administration of vitamins K2, K3 and K5 significantly suppressed the tumor growth. The number of apoptotic tumor cells was significantly larger in the vitamin K-treated groups than in the control group. These results suggest that vitamins K2, K3 and K5 exerted effective antitumor effects on CRC in vitro and in vivo by inducing caspase-dependent apoptotic death of tumor cells, suggesting that these K vitamins may be promising agents for the treatment of patients with CRC.

Emission analysis of Tb3+ -and Sm3+ -ion-doped (Li2 O/Na2 O/K2 O) and (Li2 O + Na2 O/Li2 O + K2 O/K2 O + Na2 O)-modified borosilicate glasses.

Science.gov (United States)

Naveen Kumar Reddy, B; Sailaja, S; Thyagarajan, K; Jho, Young Dahl; Sudhakar Reddy, B

2018-05-01

Four series of borosilicate glasses modified by alkali oxides and doped with Tb 3+ and Sm 3+ ions were prepared using the conventional melt quenching technique, with the chemical composition 74.5B 2 O 3 + 10SiO 2 + 5MgO + R + 0.5(Tb 2 O 3 /Sm 2 O 3 ) [where R = 10(Li 2 O /Na 2 O/K 2 O) for series A and C, and R = 5(Li 2 O + Na 2 O/Li 2 O + K 2 O/K 2 O + Na 2 O) for series B and D]. The X-ray diffraction (XRD) patterns of all the prepared glasses indicate their amorphous nature. The spectroscopic properties of the prepared glasses were studied by optical absorption analysis, photoluminescence excitation (PLE) and photoluminescence (PL) analysis. A green emission corresponding to the 5 D 4 → 7 F 5 (543 nm) transition of the Tb 3+ ions was registered under excitation at 379 nm for series A and B glasses. The emission spectra of the Sm 3+ ions with the series C and D glasses showed strong reddish-orange emission at 600 nm ( 4 G 5/2 → 6 H 7/2 ) with an excitation wavelength λ exci = 404 nm ( 6 H 5/2 → 4 F 7/2 ). Furthermore, the change in the luminescence intensity with the addition of an alkali oxide and combinations of these alkali oxides to borosilicate glasses doped with Tb 3+ and Sm 3+ ions was studied to optimize the potential alkali-oxide-modified borosilicate glass. Copyright © 2017 John Wiley & Sons, Ltd.

Study of K-π- inelastic scattering from K-p interactions at 4.2 GeV/c

International Nuclear Information System (INIS)

Voorthuis, H.; Groot, A.J. de; Jongejans, B.; Kluyver, J.C.; Kittel, E.W.; Schotanus, D.J.

1976-01-01

The isospin I=3/2K - π - inelastic scattering cross section is determined from the reactions K - p→Δ ++ (K+pions) -- at 4.2 GeV/c incident K - momentum, using a Chew-Low extrapolation method. The available statistics also allowed a determination of the cross sections for individual K - π - reactions by this method. The total inelastic K - π - scattering cross section is found to increase almost linearly with K - π - mass from - π - →(Kππ) -- contribute to the inelastic cross section; higher multiplicity K - π - interactions start to play a role above this mass. (Auth.)

Vitamin K2 for the reversal of warfarin-related coagulopathy.

Science.gov (United States)

Hifumi, Toru; Takada, Hiroaki; Ogawa, Daisuke; Suzuki, Kenta; Hamaya, Hideyuki; Shinohara, Natsuyo; Abe, Yuko; Takano, Koshiro; Kawakita, Kenya; Hagiike, Masanobu; Koido, Yuichi; Kuroda, Yasuhiro

2015-08-01

The American Heart Association/American College of Cardiology Foundation recommends vitamin K1 for warfarin-related coagulopathy. In Japan, vitamin K2 is used more commonly for such purpose. The difference between vitamins K1 and K2 in reversing warfarin-related coagulopathy has not been discussed. Herein, we report a case that was reversed with vitamin K2; alterations in vitamins K1 and K2 levels and coagulation markers are also presented.

Comparison of vitamins K1, K2 and K3 effects on growth of rat glioma and human glioblastoma multiforme cells in vitro.

Science.gov (United States)

Oztopçu, Pinar; Kabadere, Selda; Mercangoz, Ayşe; Uyar, Ruhi

2004-09-01

Glioblastoma multiforme is characterized as highly invasive and rapidly growing astrocytomas, and scientists have sought for efficient treatment against malignant gliomas for a long time. Therefore, we compared the respond of rat glioma (C6) and glioblastoma multiforme cells derived from two patients to vitamins K1, K2 and K3. The cells were exposed to 100, 250, 500, 750 and 1000 microM of vitamins K1 and K2, and 1, 10, 25, 50, 75 and 100 microM of vitamin K3 for 24 hours in an incubator atmosphere of 5% CO2, 37 degrees C and 100% humidity. Cell viability was estimated by MTT assay. Vitamin K1 showed no growth effect on all the glioma cells examined. Vitamin K2 did not cause any change in number of C6, however induced growth inhibition in a dose-dependent manner on glioblastoma multiforme. The IC50 values of vitamin K2 were 960 microM and 970 microM for glioblastoma multiforme, respectively. Vitamin K3 had also growth inhibitory effect in a dose-dependent manner on both C6 and glioblastoma multiforme. The IC50 values were 41 microM, 24 microM and 23 microM for vitamin K3, respectively. We concluded that vitamin K3 is more effective than vitamin K2 for inhibition of cancer cell growth, and might have an alternative value as an anticancer drug against glioblastoma multiforme.

10 K gate I(2)L and 1 K component analog compatible bipolar VLSI technology - HIT-2

Science.gov (United States)

Washio, K.; Watanabe, T.; Okabe, T.; Horie, N.

1985-02-01

An advanced analog/digital bipolar VLSI technology that combines on the same chip 2-ns 10 K I(2)L gates with 1 K analog devices is proposed. The new technology, called high-density integration technology-2, is based on a new structure concept that consists of three major techniques: shallow grooved-isolation, I(2)L active layer etching, and I(2)L current gain increase. I(2)L circuits with 80-MHz maximum toggle frequency have developed compatibly with n-p-n transistors having a BV(CE0) of more than 10 V and an f(T) of 5 GHz, and lateral p-n-p transistors having an f(T) of 150 MHz.

Using leap motion to investigate the emergence of structure in speech and language.

Science.gov (United States)

Eryilmaz, Kerem; Little, Hannah

2017-10-01

 In evolutionary linguistics, experiments using artificial signal spaces are being used to investigate the emergenceof speech structure. These signal spaces need to be continuous, non-discretized spaces from which discrete unitsand patterns can emerge. They need to be dissimilar from-but comparable with-the vocal tract, in order tominimize interference from pre-existing linguistic knowledge, while informing us about language. This is a hardbalance to strike. This article outlines a new approach that uses the Leap Motion, an infrared controller that canconvert manual movement in 3d space into sound. The signal space using this approach is more flexible than signalspaces in previous attempts. Further, output data using this approach is simpler to arrange and analyze. Theexperimental interface was built using free, and mostly open- source libraries in Python. We provide our sourcecode for other researchers as open source.

Potassium vanadium selenite, K(VO2)3(SeO3)2

International Nuclear Information System (INIS)

Harrison, W.T.A.; Dussack, L.L.; Jacobson, A.J.

1995-01-01

The hydrothermal synthesis and single-crystal structure of potassium vanadium(V) selenite, K(VO 2 ) 3 (SeO 3 ) 2 , are reported. K(VO 2 ) 3 (SeO 3 ) 2 is a layered phase based on a hexagonal tungsten-oxide-like array of corner-sharing VO 6 octahedra capped by Se atoms, and is isostructural with NH 4 (VO 2 ) 3 (SeO 3 ) 2 . (orig.)

Y2K compliance readiness and contingency planning.

Science.gov (United States)

Stahl, S; Cohan, D

1999-09-01

As the millennium approaches, discussion of "Y2K compliance" will shift to discussion of "Y2K readiness." While "compliance" focuses on the technological functioning of one's own computers, "readiness" focuses on the operational planning required in a world of interdependence, in which the functionality of one's own computers is only part of the story. "Readiness" includes the ability to cope with potential Y2K failures of vendors, suppliers, staff, banks, utility companies, and others. Administrators must apply their traditional skills of analysis, inquiry and diligence to the manifold imaginable challenges which Y2K will thrust upon their facilities. The SPICE template can be used as a systematic tool to guide planning for this historic event.

Neural Network Analysis of LEAP Energy Spectra

Energy Technology Data Exchange (ETDEWEB)

Holdridge, Robert E

2002-09-10

The Laser Electron Acceleration Project (LEAP) group has been conducting a proof of principle experiment on the acceleration of electrons with a pair of crossed laser beams. To date there has been no experimental verification of electron acceleration with crossed laser beams in a dielectric loaded vacuum, although the energy profile of an accelerated electron bunch has been well described by theory. The experiment is subject to unavoidable time dependent fluctuations in the independent variables. Changes in the experimental parameters can dramatically alter the beam profile incident near the focal plane of a high-resolution spectrometer located downstream from the accelerator cell. Neural networks (NNs) appear to provide an ideal tool for the positive determination of an acceleration event, being adaptable and able to handle highly complex nonlinear problems. Typical NNs under such conditions require a training set consisting of a representative data set along with ''answers'' which have been determined to be consistent with the variable state of the experimental parameters. A strategy of pattern recognition with respect to the status of independent variables can be employed to determine the signature characteristics of a laser perturbed electron bunch. Data cuts representing characteristics that were thought to be distinctive to accelerated beam profile images were implemented in the algorithm employed. Statistical analysis of the results of data cuts made on the energy profile images from the experiment is presented, as well as conclusions drawn from the results of this analysis. Finally, a discussion of future directions to be taken in this work is given including the orientation towards on-line, real-time analysis.

H2A/K pseudogene mutation may promote cell proliferation

Energy Technology Data Exchange (ETDEWEB)

Guo, Jisheng; Jing, Ruirui; Lv, Xin; Wang, Xiaoyue; Li, Junqiang; Li, Lin; Li, Cuiling; Wang, Daoguang; Bi, Baibing; Chen, Xinjun [Cancer Research Center, Shandong University School of Medicine, Jinan 250012 (China); Yang, Jing-Hua, E-mail: sdu_crc_group1@126.com [Cancer Research Center, Shandong University School of Medicine, Jinan 250012 (China); Department of Surgery, VA Boston Healthcare System, Boston University School of Medicine, Boston 510660, MA (United States)

2016-05-15

Highlights: • The mutant H2A/K pseudogene is active. • The mutant H2A/K pseudogene can promote cell proliferation. - Abstract: Little attention has been paid to the histone H2A/K pseudogene. Results from our laboratory showed that 7 of 10 kidney cancer patients carried a mutant H2A/K pseudogene; therefore, we were interested in determining the relationship between mutant H2A/K and cell proliferation. We used shotgun and label-free proteomics methods to study whether mutant H2A/K lncRNAs affected cell proliferation. Quantitative proteomic analysis indicated that the expression of mutant H2A/K lncRNAs resulted in the upregulation of many oncogenes, which promoted cell proliferation. Further interaction analyses revealed that a proliferating cell nuclear antigen (PCNA)-protein interaction network, with PCNA in the center, contributes to cell proliferation in cells expressing the mutant H2A/K lncRNAs. Western blotting confirmed the critical upregulation of PCNA by mutant H2A/K lncRNA expression. Finally, the promotion of cell proliferation by mutant H2A/K lncRNAs (C290T, C228A and A45G) was confirmed using cell proliferation assays. Although we did not determine the exact mechanism by which the oncogenes were upregulated by the mutant H2A/K lncRNAs, we confirmed that the mutant H2A/K lncRNAs promoted cell proliferation by upregulating PCNA and other oncogenes. The hypothesis that cell proliferation is promoted by the mutant H2A/K lncRNAs was supported by the protein expression and cell proliferation assay results. Therefore, mutant H2A/K lncRNAs may be a new factor in renal carcinogenesis.

New results from T2K

CERN Multimedia

CERN. Geneva

2013-01-01

The Tokai to Kamioka (T2K) experiment is a long baseline neutrino oscillation experiment situated in Japan. A high intensity neutrino beam is produced at the Japan Proton Accelerator Research Complex, in Tokai, Japan. In 2011, the collaboration announced the first indication of muon neutrino to electron neutrino transformation, which was then a new type of neutrino oscillation; now, with 3.5 times more data, this transformation is firmly established. This T2K observation is the first of its kind in that an explicit appearance of a unique flavor of neutrino at a detection point is unequivocally observed from a different flavor of neutrino at its production point. The T2K collaboration also reports a precision measurement of muon neutrino disappearance with an ooff-axis neutrino beam with a peak energy of 0.6 GeV. Near detector is used in both oscillation measurements to constrain the neutrino flux and cross section parameters.

Resolving power test of 2-D K{sup +} K{sup +} interferometry

Energy Technology Data Exchange (ETDEWEB)

Padula, Sandra S.; Roldao, Christiane G. [Instituto de Fisica Teorica (IFT), Sao Paulo, SP (Brazil)

1999-07-01

Adopting a procedure previously proposed to quantitatively study pion interferometry {sup 1} , an equivalent 2-D X{sup 2} analysis was performed to test the resolving power of that method when applied to less favorable conditions, when no significant contribution from long lived resonances is expected, as in kaon interferometry. For that purpose, use is made of the preliminary E859 K{sup +}K{sup +} interferometry data from Si+Au collisions at 14.6 A GeV/c. Less sensitivity is achieved in the present case, although it is shown that it is still possible to distinguish two distinct decoupling geometries. (author)

Nascap-2k Version 4.2 Scientific Documentation

Science.gov (United States)

2014-10-31

electric and magnetic fields inside the sheath. The sheath surface is taken as the equipotential surface at φ = ±θln2. This choice is made because the...models used in the surface charging, potential solution, and particle tracking portions of the code. 15. SUBJECT TERMS Nascap-2k, Spacecraft...PHYSICAL MODELS ............................................................................................................ 2 2.1 Surface Charging from

Different metabolic profiles of K1 serotype and non-serotype K1 and K2 Klebsiella pneumoniae isolates in oral infection mice model.

Science.gov (United States)

Chen, Nan; Wang, Lin-Lin; Xue, Juan; Ma, Xiang-Bo; Zhao, Sheng; Rong, Rui-Xue; Li, Hong-Quan; Ding, Liang; Zheng, Ming-Zhi; Chen, Ying-Ying; Duan, Fei; Shen, Yue-Liang

2014-10-01

K1 or K2 serotype Klebsiella pneumoniae isolate caused clinical pyogenic liver abscess (KLA) infection is prevalent in many areas. It has been identified that K1 or K2 serotype K. pneumoniae isolates caused KLA infection in mice by oral inoculation. In our study, K1 serotype K. pneumoniae isolate Kp1002 with hypermucoviscosity (HV)-positive phenotype caused KLA infection in C57BL/6 mice by oral inoculation. Simultaneously, non-serotype K1 and K2 isolate Kp1014 with HV-negative phenotype failed to cause KLA infection in the same manner. It seems that gastrointestinal tract translocation is the pathway by which K1 or K2 serotype K. pneumoniae caused KLA infection. Liquid chromatography-tandem mass spectrometry was used to further analyze metabolic profile changes in mice with KLA infection. Data showed that after Kp1002 or Kp1014 oral inoculation, serum Phosphatidylcholine (PC) and Lysophosphatidylcholine (LPC) levels significantly changed in mice. Some PC and LPC molecules showed changes both in the Kp1002 KLA group and the Kp1014 no-KLA group compared with the control group. The level of 18:1/18:2-PC significantly changed in the Kp1002 KLA group compared with the control group, but showed no change between the Kp1014 no-KLA group and the control group. The level of 18:1/18:2-PC might have been particularly affected by KLA infection caused by K1 serotype K. pneumoniae Kp1002. It may be a potential biomarker for KLA infection. Copyright © 2014 Elsevier Ltd. All rights reserved.

Phase formation in the Li2MoO4–K2MoO4–In2(MoO4)3 system and crystal structures of new compounds K3InMo4O15 and LiK2In(MoO4)3

International Nuclear Information System (INIS)

Khal’baeva, Klara M.; Solodovnikov, Sergey F.; Khaikina, Elena G.; Kadyrova, Yuliya M.; Solodovnikova, Zoya A.; Basovich, Olga M.

2012-01-01

XRD study of solid-phase interaction in the Li 2 MoO 4 –K 2 MoO 4 –In 2 (MoO 4 ) 3 system was performed. The boundary K 2 MoO 4 –In 2 (MoO 4 ) 3 system is an non-quasibinary join of the K 2 O–In 2 O 3 –MoO 3 system where a new polymolybdate K 3 InMo 4 O 15 isotypic to K 3 FeMo 4 O 15 was found. In the structure (a=33.2905(8), b=5.8610(1), c=15.8967(4) Å, β=90.725(1)°, sp. gr. C2/c, Z=8, R(F)=0.0407), InO 6 octahedra, Mo 2 O 7 diortho groups and MoO 4 tetrahedra form infinite ribbons {[In(MoO 4 ) 2 (Mo 2 O 7 )] 3− } ∞ along the b-axis. Between the chains, 8- to 10-coordinate potassium cations are located. A subsolidus phase diagram of the Li 2 MoO 4 –K 2 MoO 4 –In 2 (MoO 4 ) 3 system was constructed and a novel triple molybdate LiK 2 In(MoO 4 ) 3 was revealed. Its crystal structure (a=7.0087(2), b=9.2269(3), c=10.1289(3) Å, β=107.401(1)°, sp. gr. P2 1 , Z=2, R(F)=0.0280) contains an open framework of vertex-shared MoO 4 tetrahedra, InO 6 octahedra and LiO 5 tetragonal pyramids with nine- and seven-coordinate potassium ions in the framework channels. - Graphical abstract: Exploring the Li 2 MoO 4 –K 2 MoO 4 –In 2 (MoO 4 ) 3 system showed its partial non-quasibinarity and revealed new compounds K 3 InMo 4 O 15 (isotypic to K 3 FeMo 4 O 15 ) and LiK 2 In(MoO 4 ) 3 which were structurally studied. An open framework of the latter is formed by vertex-shared MoO 4 tetrahedra, InO 6 octahedra and LiO 5 tetragonal pyramids. Highlights: ► Subsolidus phase relations in the Li 2 MoO 4 –K 2 MoO 4 –In 2 (MoO 4 ) 3 system were explored. ► The K 2 MoO 4 –In 2 (MoO 4 ) 3 system is a non-quasibinary join of the K 2 O–In 2 O 3 –MoO 3 system. ► New compounds K 3 InMo 4 O 15 and LiK 2 In(MoO 4 ) 3 were obtained and structurally studied. ► K 3 InMo 4 O 15 is isotypic to K 3 FeMo 4 O 15 and carries bands of InO 6 , MoO 4 and Mo 2 O 7 units. ► An open framework of LiK 2 In(MoO 4 ) 3 is formed by polyhedra MoO 4 , InO 6 and LiO 5 .

A kinetic study on the catalysis of KCl, K2SO4, and K2CO3 during oxy-biomass combustion.

Science.gov (United States)

Deng, Shuanghui; Wang, Xuebin; Zhang, Jiaye; Liu, Zihan; Mikulčić, Hrvoje; Vujanović, Milan; Tan, Houzhang; Duić, Neven

2018-07-15

Biomass combustion under the oxy-fuel conditions (Oxy-biomass combustion) is one of the approaches achieving negative CO 2 emissions. KCl, K 2 CO 3 and K 2 SO 4 , as the major potassium species in biomass ash, can catalytically affect biomass combustion. In this paper, the catalysis of the representative potassium salts on oxy-biomass combustion was studied using a thermogravimetric analyzer (TGA). Effects of potassium salt types (KCl, K 2 CO 3 and K 2 SO 4 ), loading concentrations (0, 1, 3, 5, 8 wt%), replacing N 2 by CO 2 , and O 2 concentrations (5, 20, 30 vol%) on the catalysis degree were discussed. The comparison between TG-DTG curves of biomass combustion before and after water washing in both the 20%O 2 /80%N 2 and 20%O 2 /80%CO 2 atmospheres indicates that the water-soluble minerals in biomass play a role in promoting the devolatilization and accelerating the char-oxidation; and the replacement of N 2 by CO 2 inhibits the devolatilization and char-oxidation processes during oxy-biomass combustion. In the devolatilization stage, the catalysis degree of potassium monotonously increases with the increase of potassium salt loaded concentration. The catalysis degree order of the studied potassium salts is K 2 CO 3  > KCl > K 2 SO 4 . In the char-oxidation stage, with the increase of loading concentration the three kinds of potassium salts present inconsistent change tendencies of the catalysis degree. In the studied loading concentrations from 0 to 8 wt%, there is an optimal loading concentration for KCl and K 2 CO 3 , at 3 and 5 wt%, respectively; while for K 2 SO 4 , the catalysis degree on char-oxidation monotonically increases with the loading potassium concentration. For most studied conditions, regardless of the potassium salt types or the loading concentrations or the combustion stages, the catalysis degree in the O 2 /CO 2 atmosphere is stronger than that in the O 2 /N 2 atmosphere. The catalysis degree is also affected by the O 2

Phase diagrams and physicochemical properties of Li+,K+(Rb+)//borate-H2O systems at 323 K

Science.gov (United States)

Feng, Shan; Yu, Xudong; Cheng, Xinglong; Zeng, Ying

2017-11-01

The phase and physicochemical properties diagrams of Li+,K+(Rb+)//borate-H2O systems at 323 K were constructed using the experimentally measured solubilities, densities, and refractive indices. The Schreinemakers' wet residue method and the X-ray diffraction were used for the determination of the compositions of solid phase. Results show that these two systems belong to the hydrate I type, with no solid solution or double salt formation. The borate phases formed in our experiments are RbB5O6(OH)4 · 2H2O, Li2B4O5(OH)4 · H2O, and K2B4O5(OH)4 · 2H2O. Comparison between the stable phase diagrams of the studied system at 288, 323, and 348 K show that in this temperature range, the crystallization form of salts do not changed. With the increase in temperature, the crystallization field of Li2B4O5(OH)4 · H2O salt at 348 K is obviously larger than that at 288 K. In the Li+,K+(Rb+)//borate-H2O systems, the densities and refractive indices of the solutions (at equilibrium) increase along with the mass fraction of K2B4O7 (Rb2B4O7), and reach the maximum values at invariant point E.

A 2.5-kW industrial CO2 laser

Science.gov (United States)

Golov, V. K.; Ivanchenko, A. I.; Krasheninnikov, V. V.; Ponomarenko, A. G.; Shepelenko, A. A.

1986-06-01

A fast-flow laser is reported in which the active medium is excited by a self-sustained dc discharge produced by an electric-discharge device with nonsectioned electrodes. In the laser, two discharge gaps are formed by a flat anode and two cathodes, one on each side of the anode. A gas mixture is driven through the gasdynamic channel by a centrifugal fan rotating at 6000 rpm/min. With a mixture of CO2:N2:He = 2.5:7.5:5 mm Hg, the rated power is 2.5 kW; the maximum power is 4 kW with the mixture 2.5:7.5:10 mm Hg. The general design of the laser is described, and its principal performance characteristics are given.

Design, construction, and operation of SciFi tracking detector for K2K experiment

International Nuclear Information System (INIS)

Suzuki, A.; Park, H.; Aoki, S.; Echigo, S.; Fujii, K.; Hara, T.; Iwashita, T.; Kitamura, M.; Kohama, M.; Kume, G.; Onchi, M.; Otaki, T.; Sato, K.; Takatsuki, M.; Takenaka, K.; Tanaka, Y.; Tashiro, K.; Inagaki, T.; Kato, I.; Mukai, S.; Nakaya, T.; Nishikawa, K.; Sasao, N.; Shima, A.; Yokoyama, H.; Chikamatsu, T.; Hayato, Y.; Ishida, T.; Ishii, T.; Ishino, H.; Jeon, E.J.; Kobayashi, T.; Lee, S.B.; Nakamura, K.; Oyama, Y.; Sakai, A.; Sakuda, M.; Tumakov, V.; Fukuda, S.; Fukuda, Y.; Ishizuka, M.; Itow, Y.; Kajita, T.; Kameda, J.; Kaneyuki, K.; Kobayashi, K.; Kobayashi, Y.; Koshio, Y.; Miura, M.; Moriyama, S.; Nakahata, M.; Nakayama, S.; Obayashi, Y.; Okada, A.; Sakurai, N.; Shiozawa, M.; Suzuki, Y.; Takeuchi, H.; Takeuchi, Y.; Totsuka, Y.; Toshito, T.; Yamada, S.; Miyano, K.; Nakamura, M.; Tamura, N.; Nakano, I.; Yoshida, M.; Kadowaki, T.; Kishi, S.; Yokoyama, H.; Maruyama, T.; Etoh, M.; Nishijima, K.; Bhang, H.C.; Khang, B.H.; Kim, B.J.; Kim, H.I.; Kim, J.H.; Kim, S.B.; So, H.; Yoo, J.H.; Choi, J.H.; Jang, H.I.; Jang, J.S.; Kim, J.Y.; Lim, I.T.; Pac, M.Y.; Kearns, E.; Scholberg, K.; Stone, J.L.; Sulak, L.R.; Walter, C.W.; Casper, D.; Gajewski, W.; Kropp, W.; Mine, S.; Sobel, H.; Vagins, M.; Matsuno, S.; Hill, J.; Jung, C.K.; Martens, K.; Mauger, C.; McGrew, C.; Sharkey, E.; Yanagisawa, C.; Berns, H.; Boyd, S.; Wilkes, J.; Kielczewska, D.; Golebiewska, U.

2000-01-01

We describe the construction and performance of a scintillating fiber detector used in the near detector for the K2K (KEK to Kamioka, KEK E362) long baseline neutrino oscillation experiment. The detector uses 3.7 m long and 0.692 mm diameter scintillating fiber coupled to image-intensifier tubes (IIT), and a CCD camera readout system. Fiber sheet production and detector construction began in 1997, and the detector was commissioned in March 1999. Results from the first K2K runs confirm good initial performance: position resolution is estimated to be about 0.8 mm, and track finding efficiency is 98±2% for long tracks (i.e., those which intersect more than 5 fiber planes). The hit efficiency was estimated to be 92±2% using cosmic-ray muons, after noise reduction at the offline stage. The possibility of using the detector for particle identification is also discussed

CCT-K2.1: NRC/VNIIFTRI bilateral comparison of capsule-type standard platinum resistance thermometers from 13.8 K to 273.16 K

Energy Technology Data Exchange (ETDEWEB)

Hill, K.D.; Steele, A.G. [National Research Council of Canada, Institute for National Measurement Standards, Ottawa, ON (Canada); Dedikov, Y.A.; Shkraba, V.T. [Institute for Physical-Technical and Radiotechnical Measurements (VNIIFTRI), Moscow (Russian Federation)

2005-04-01

The Consultative Committee for Thermometry Key Comparison 2 (CCT-K2) results were published two years ago (2002 Metrologia 39 551-71). NRC served as the pilot laboratory for CCT-K2 and remains able to provide a scale and measurement system suitable for performing bilateral comparisons linked to the original key comparison results. In March 2003, measurements of two VNIIFTRI 100 {omega} capsule-style platinum resistance thermometers (CSPRTs), S/N 356 and 476, were undertaken to relate their local calibration to the results from the CCT-K2 exercise. The NRC Leeds and Northrup (L and N) CSPRT S/N 1872174 provides the link to the CCT-K2 results. The three CSPRTs were compared at the eight defining cryogenic temperatures of the International Temperature Scale of 1990 (ITS-90) in the range from 13.8033 K to 273.16 K. The reader is referred to the full text of the CCT-K2 report for a detailed explanation of the methodology employed for the comparison. Only the details unique to the measurements reported here will be addressed in this article. The NRC/VNIIFTRI bilateral comparison of capsule-style platinum resistance thermometers over the range 13.8 K to 273.16 K has revealed calibrations at VNIIFTRI to be in agreement with the KCRV of CCT-K2 within the expanded uncertainty for all temperatures of the comparison with the exception of the triple point of hydrogen at 13.8033 K. One of the two CSPRTs supplied by VNIIFTRI was found to be discrepant as revealed by differences at the triple point of water and at the lowest temperatures of the comparison, and was therefore excluded from further analysis. The linkage to the CCT-K2 data supports the evaluation of the VNIIFTRI CMCs in Appendix C of the KCDB. (authors)

Electrochemical Behavior of Molten V2O5-K2S2O7-KHSO4 Systems

DEFF Research Database (Denmark)

Petrushina, Irina; Bjerrum, Niels; Berg, Rolf W.

1997-01-01

The electrochemical behavior of K2S2O7-KHSO4-V2O5, K2S2O7-V2O4 and K2S2O7-KHSO4-V2O4 melts was studied in argon and SO2/air atmospheres using a gold electrode. In order to identify the voltammetric waves due to KHSO4, molten KHSO4 and mixtures of K2S2O7-KHSO4 were investigated by voltammetry...

Design of a large 2.0 k refrigerator for CEBAF

International Nuclear Information System (INIS)

Parish, H.; Hood, C.; Kreinbrink, K.; Appleton, W.; Gistau, G.

1991-01-01

The CEBAF refrigerator is designed to produce 4,620 watts of refrigeration at 2.0 K, another 180 watts at 2.14 K plus 4.5 K liquid and higher temperature cooling for shields. Several design features are described, including a modular concept for the 2 K and 4.5 K refrigerator sections and the use of multistage centrifugal cryogenic compressors to achieve the 2 K. The development program for the centrifugal cryogenic compressors is discussed. Some startup information is also provided

Y2K compliance countdown.

Science.gov (United States)

Arlotto, P W

1999-01-01

The new century brings unique challenges--especially Y2K compliance. This article presents nurse managers and executives with an overview of the issues and action steps to keep their organizations on track.

Specificity of the Spectrophotometry for Detecting Aminopolyether K2.2.2 in 18F-FDG

Directory of Open Access Journals (Sweden)

ZHANG Jin-ming

2015-11-01

Full Text Available 氨基聚醚(K2.2.2含量是18F-FDG质控中的关键指标，比较了两种常用测量K2.2.2方法的专属性。分别采用分光光度计和半定量TLC 碘显色法测量了14个样品，其中9个阴性样品、2个阳性样品和3个供试品，并与LC-MS/MS测量对比。结果显示：9个阴性样品经分光光度计法测量均为阳性，K2.2.2的测量结果在6.7～470.0 μg/mL；2个阳性样品结果偏高（53，73 μg/mL），3个供试品的K2.2.2含量在14.3~19.2 μg/mL；半定量TLC 碘显色法测量9个阴性样品结果为阴性,2个阳性样品半定量结果与实际一致,3个供试品的K2.2.2含量低于10 μg/mL;LC-MS/MS法测量的14个样品的结果与半定量TLC 碘显色法的结果一致。以上结果表明，半定量TLC 碘显色法测量K2.2.2的专属性较好，适用于测量18F-FDG溶液中K2.2.2含量。

The exoplanet population revealed by K2

Science.gov (United States)

Barentsen, Geert; Dotson, Jessie; Colon, Knicole; Hedges, Christina; Team K2

2018-01-01

NASA's K2 survey has expanded the legacy of the Kepler mission by using the repurposed spacecraft to probe short-period planets around a more diverse population of stars: probing nearby dwarfs through distant giants; young pre-main sequence stars through evolved white dwarfs; halo stars through bulge members. I will review the star and planet population sampled by K2 across 16 fields so far, highlighting several characteristics, caveats, and unexplored uses of the public data set along the way. With fuel expected to run out in 2018, I will discuss the closing Campaigns, highlight the final target selection opportunities, and explain the data archive and TESS-compatible software tools the K2 mission intends to leave behind for posterity.

Final design of kaon beam K2 at KEK

International Nuclear Information System (INIS)

Kurokawa, Shin-ichi; Yamamoto, Akira.

1977-09-01

Final design of the 2.3 GeV/c kaon beam K2 is given. The K2 beam starts from the production target in slow extracted beam. Momentum range is 1 GeV/c through 2.3 GeV/c. Nominal total beam length is 27.9 m and solid-angle momentum acceptance is 6.25 msr%ΔP/P. Using a platinum target of diameter 3 mm and length 6 cm, 2.0 GeV/c beam fluxes of 1.0 x 10 6 K + and 5.2 x 10 5 K - per 10 12 13 GeV/c incident protons are expected at the final focus. (auth.)

New results from T2K

Science.gov (United States)

Longhin, A.

2017-12-01

The T2K experiment is a 295-km long-baseline neutrino experiment in Japan employing an off-axis muon neutrino beam with a 0.6 GeV peak energy. The beam, produced from 30-GeV protons at the J-PARC complex on the Pacific coast, is directed to the Super-Kamiokande detector. T2K released the first long-baseline measurement of a nonzero value for the θ13 mixing parameter through the observation of electron neutrino appearance (vµ → ve) and produced the most precise measurement of θ23 through the observation of muon neutrino disappearance (vµ → vµ). T2K data, in combination with reactor experiments, also excludes at 90% C.L. a significant region of the Dirac CP phase: δCP -0.49(-0.98) for the normal (inverted) hierarchy. A full joint appearance and disappearance fit including both neutrino (7×1020 protons on target, PoT) and anti-neutrino (4 × 1020 PoT) data and, for the first time, a constraint from water target data in the near detector, is presented yielding improved sensitivity on δCP and improved precision on sin2 2θ23 and the atmospheric mass splitting.

Construction of non-viral vector (mPEG5k-PCL1.2k)1.4-g-PEI10k and its gene delivery efficacy in vitro

OpenAIRE

Wei HUANG; Ming LV; Zhong-gao GAO; Ming-ji JIN; Fei-fei YANG; Yu-li WANG

2011-01-01

Objective To construct(mPEG5k-PCL1.2k)1.4-g-PEI10k,a copolymer designed as delivery vector for non-viral gene therapy,and explore its cytotoxicity and efficacy in delivery of plasmid DNA(pDNA).Methods The copolymer,mPEG5k-PCL1.2k-OH,was prepared by ring-opening polymerization and then followed by a conversion of hydroxyl terminal(-OH) into N-hydroxysuccinimide(NHS) to prepare mPEG5k-PCL1.2k-NHS.One of the branches,PEI10k,was then reacted with mPEG5k-PCL1.2k-NHS to synthesize a ternary copolym...

Raman Spectroscopy evidence of 1:1:1 complex formation during dissolution of WO3 : K2SO4 in a melt of K2S2O7

DEFF Research Database (Denmark)

Berg, Rolf W.; Maijó Ferré, Irene

2005-01-01

The dissolution reaction of solid WO3 into a melt consisting of a 1:1 molar mixture of K2S2O7 and K2SO4 was studied by Raman spectroscopy. It was found that a new compound was formed, dimeric K8[(WO2)2(m-SO4)2(SO4)4]. The assigned Raman spectrum is given. Extended abstract of Poster presented...

Comparison between calibration methods of ionization chamber type pencil in greatness P_K_L

International Nuclear Information System (INIS)

Macedo, E.M.; Pereira, L.C.S.; Ferreira, M.J.; Navarro, V.C.C.; Garcia, I.F.M.; Pires, E.J.; Navarro, M.V.T.

2016-01-01

Calibration of radiation meters is indispensable on Quality Assurance Program in Radiodiagnostic procedures, mainly Computed Tomography. Thus, this study aims evaluate two calibration methods of pencil ionization chambers in terms of Kerma-length Product (P_K_L) (a direct substitution method and an indirect one, through Kerma and length measurements). The results showed a good equivalence, with minimal concordance of 98,5% between calibration factors. About uncertainties, both showed similar results (substitution 2.2% and indirect 2.3%), indicating that the last one is better, due the costs reduction to implant this calibration procedure. (author)

Leap motion controlled videogame-based therapy for rehabilitation of elderly patients with subacute stroke: a feasibility pilot study.

Science.gov (United States)

Iosa, Marco; Morone, Giovanni; Fusco, Augusto; Castagnoli, Marcello; Fusco, Francesca Romana; Pratesi, Luca; Paolucci, Stefano

2015-08-01

The leap motion controller (LMC) is a new optoelectronic system for capturing motion of both hands and controlling a virtual environment. Differently from previous devices, it optoelectronically tracks the fine movements of fingers neither using glows nor markers. This pilot study explored the feasibility of adapting the LMC, developed for videogames, to neurorehabilitation of elderly with subacute stroke. Four elderly patients (71.50 ± 4.51 years old) affected by stroke in subacute phase were enrolled and tested in a cross-over pilot trial in which six sessions of 30 minutes of LMC videogame-based therapy were added on conventional therapy. Measurements involved participation to the sessions, evaluated by means of the Pittsburgh Rehabilitation Participation Scale, hand ability and grasp force evaluated respectively by means of the Abilhand Scale and by means of the dynamometer. Neither adverse effects nor spasticity increments were observed during LMC training. Participation to the sessions was excellent in three patients and very good in one patient during the LMC trial. In this period, patients showed a significantly higher improvement in hand abilities (P = 0.028) and grasp force (P = 0.006). This feasibility pilot study was the first one using leap motion controller for conducting a videogame-based therapy. This study provided a proof of concept that LMC can be a suitable tool even for elderly patients with subacute stroke. LMC training was in fact performed with a high level of active participation, without adverse effects, and contributed to increase the recovery of hand abilities.

Kepler: A Search for Terrestrial Planets. K2 Handbook

Science.gov (United States)

Van Cleve, Jeffrey; Bryson, Steve

2017-01-01

The Kepler spacecraft was repurposed for the K2 mission a year after the failure of the second of Kepler's four reaction wheels in 2013 May. The purpose of this document, the K2 Handbook (K2H), is to describe features of K2 operations, performance, data analysis, and archive products which are common to most K2 campaigns, but different in degree or kind from the corresponding features of the Kepler mission.The K2 Handbook is meant to be read with the following companion documents, which are all publicly available:1. Kepler Instrument Handbook (KSCI-19033) provides information about the design, performance and operational constraints of the instrument and an overview of the types of pixel data that are available.2. Kepler Data Processing Handbook (KSCI-19081) describes how pixels downloaded from the spacecraft are converted by the Kepler Data Processing Pipeline into the data products available at the MAST archive3. Kepler Archive Manual (KDMC-100008) describes the format and content of the data products and how to search for them.4. Kepler Data Characteristics Handbook (KSCI-19040) describes recurring non-astrophysical features of the Kepler data due to instrument signatures, spacecraft events or solar activity and explains how these characteristics are handled by the Kepler pipeline.5. The Ecliptic Plane Input Catalog describes the provenance of the positions and Kepler magnitudes used for target management and aperature photometry.6. K2 Data Release Notes (DRN) are on-line documents available on the K2 science website which describe the data inventory, instrumental signatures and events peculiar to individual observing campaigns.

Indirana chiravasi, a new species of Leaping Frog (Anura: Ranixalidae from Western Ghats of India

Directory of Open Access Journals (Sweden)

A.D. Padhye

2014-09-01

Full Text Available Indirana chiravasi, a new species of leaping frog is described from the northern Western Ghats around Amboli, Sindhudurg District, Maharashtra, India. It differs from all its congeners based on a combination of characters including presence of median single internal vocal sac, head longer than wide, distinct canthus rostralis, tympanum 2/3rd to 3/4th the diameter of eye, vomerine teeth in two oblique series at the posterior border of choanae, long midventral lingual papilla, first finger longer than or equal to second, presence of double outer palmer tubercle, thin and elongated inner metatarsal tubercle, absence of outer metatarsal tubercle, webbing moderate, dorsal skin with glandular folds but without warts, ventral skin smooth without mottling and palms and soles dark brown. Molecular analysis based on mitochondrial 12S and 16S genes and nuclear rhodopsin and rag1 genes suggests that the species is genetically distinct from other species for which genetic data is available. Preliminary observations on the development of the species are also provided. We also provide genetic data and images for Indirana gundia collected from the type locality.

Raman Spectroscopy Evidence of 1:1:1 Complex Formation during Dissolution of WO3 in a Melt of K2S2O7: K2SO4

DEFF Research Database (Denmark)

Berg, Rolf W.; Ferré, Irene Maijó; Schäffer, Susan Jeanne Cline

2006-01-01

Highly inert yellow solid WO3 was found to be soluble in considerable amounts in molten K2S2O7 at elevated temperatures (650 8C), if only similar molar amounts of sulfates were also present. The dissolution reaction of WO3 into a melt consisting of a 1:1 molar mixture of K2S2O7 and K2SO4...

Temperature dependence of muonium spin exchange with O2 in the range 88 K to 478 K

International Nuclear Information System (INIS)

Senba, M.; Garner, D.M.; Arseneau, D.J.; Fleming, D.G.

1984-01-01

The authors have extended an earlier study of the spin exchange reactions of Mu with O 2 in the range 295 K to 478 K, to a low temperature region down to 88 K. From 135 K to 296 K, the spin depolarization rate constant was found to vary according to the relative velocity of the colliding species, which indicates that the spin exchange cross section of Mu-O 2 is temperature independent in this range. However, it was found that below 105 K and above 400 K, the spin depolarization rate constant tends to have stronger temperature dependences. (Auth.)

With a 2k-ADC to 4k-spectrometry via two biased amplifiers

Energy Technology Data Exchange (ETDEWEB)

Goerner, W; Kleeberg, H [Zentralinstitut fuer Kernforschung, Rossendorf bei Dresden (German Democratic Republic)

1978-01-12

In order to obtain the double digital spread in high resolution nuclear spectrometry, two biased amplifiers were linked in parallel mode to the 10 V-input of a 2k-ADC. The arrangement works like a hybrid (1 bit scale - 11 bits Wilkinson) converter. A careful adjustment of the two bias levels (approximately 0V and approximately 6V) and the post-amplification (approximately 2) delivered a good linearity of the 4k-spectrum.

Y2K: the moment of truth.

Science.gov (United States)

Chepesiuk, R

1999-05-01

It remains to be seen whether the world will move in time to fix the Y2K bug, or whether computers around the world will shut down when the clock strikes midnight on 31 December 1999. Y2K could have a serious impact on environmental facilities, particularly given the extent to which computer software and microchips are now involved in pollution control and environmental monitoring and protection systems.

The collision cross sections for excitation energy transfer in Rb*(5P3/2)+K(4S1/2)→Rb(5S1/2)+K*(4PJ) processes

International Nuclear Information System (INIS)

Horvatic, V.; Vadla, C.; Movre, M.

1993-01-01

The collisional excitation transfer for the processes Rb * (5P 3/2 ) + K(4S 1/2 ) → Rb(5S 1/2 ) + K * (4P J ), J = 1/2, 3/2, was investigated using two-photon laser excitation techniques with a thermionic heat-pipe diode as a detector. The population densities of the K 4P J levels induced by collisions with excited Rb atoms as well as those produced by direct laser excitation of the potassium atoms were probed through the measurement of the thermionic signals generated due to the ionization of the potassium atoms emerging from the K(4P J ) → K(7S 1/2 ) excitation channel. (orig./WL)

Study of the expected performance of the T2K experiment on muon neutrino to electron neutrino oscillation using data from K2K experiment

International Nuclear Information System (INIS)

Fechner, M.

2006-05-01

T2K is a neutrino oscillation experiment that will use the intense 2.5 degrees off-axis ν μ beam produced at J-PARC (Japan). The far detector is Super-Kamiokande (SK), the 50 kt water Cherenkov detector located 295 km from J-PARC. The goal is to search for ν e appearance, which will bring new information on θ 13 . The main background for ν e appearance comes from intrinsic beam ν e events (∼ 55%), and from mis-identified neutral current π 0 events (∼ 45%); near detectors are needed to measure these background components before oscillation. A detector complex (2KM) including a water Cherenkov detector, located ∼ 1.8 km away from the source is under active study. This distance is advantageous because the neutrino spectrum is only a few percent different from that of SK, thereby reducing extrapolation systematics. In order to match SK performance, the water Cherenkov detector was designed with ∼ 5600 8-inch photo-multiplier tubes, after studies based on full simulation tuned to K2K data. The water Cherenkov reconstruction algorithms, mainly particle identification and e/π 0 separation, were also studied at 2KM. Studies of ν e appearance in the water Cherenkov detector show that using simple scaling extrapolation we conservatively predict 23.0 ± 8.0% (stat + syst) background events at SK for 5. 10 21 p.o.t., in excellent agreement with the 23.8 background events obtained from an independent simulation of SK. The 2KM detector can achieve background subtraction to better than 10% accuracy, sufficient for T2K phase I. Detailed sensitivity studies, including all the relevant sources of systematics, show that the 2KM detector improves the sensitivity to sin 2 (2θ 13 ) down to ∼ 1.4. 10 -2 at 90% CL. (author)

Y2K Embedded Systems.

Science.gov (United States)

Spoonemore, L. Joe

1999-01-01

Discusses facility managers' preparedness for dealing with the Y2K bug and ways to systematically assess and avoid its impact. Tips for reducing computerized system failure as facility managers make their transition into the next century conclude the article. (GR)

Ionic conductivity and Raman spectra of Na--Li, K--Li, and K--Sn β-Al2O3

International Nuclear Information System (INIS)

Kaneda, T.; Bates, J.B.; Wang, J.C.; Engstrom, H.

1979-01-01

The ionic conductivity and Raman spectra of Na, Na--Li, K, K--Li, and K--Sn β-Al 2 O 3 were measured in order to understand the mechanisms of mixed-ion conduction. It was observed that at 300 0 K, for example, the conductivity of a crystal with composition Na 0 . 82 Li 0 . 18 β-Al 2 O 3 was about one-fifth that of pure Na cyrstals, while the conductivity of K 0 . 80 Li 0 . 20 β-Al 2 O 3 was more than three orders of magnitude lower than that of pure K compounds. The results of a model calculation indicated that the Li + ions are the main carrier species in the Na--Li and K--Li mixed compounds. Features observed in the Raman spectra were attributed to paired- and single-ion vibrations. It is concluded that the K + ions which contribute to a band at 69 cm -1 in K β-Al 2 O 3 are the effective carriers for conduction

Raman Spectroscopic Study of Tungsten(VI) Oxosulfato Complexes in WO3–K2S2O7–K2SO4 Molten Mixtures: Stoichiometry, Vibrational Properties and Molecular Structure

DEFF Research Database (Denmark)

Paulson, Andreas L.; Kalampounias, Angelos G.; Berg, Rolf W.

2011-01-01

The dissolution reaction of WO3 in pure molten K2S2O7 and in molten K2S2O7-K2SO4 mixtures is studied under static equilibrium conditions in the XWO3 0 = 0-0.33 mol fraction range at temperatures up to 860 C. High temperature Raman spectroscopy shows that the dissolution leads to formation of WVI...... configuration as a core unit within the oxosulfato complexes formed. A quantitative exploitation of the relative Raman intensities in the binary WO3-K2S2O7 system allows the determination of the stoichiometric coefficient, n, of the complex formation reaction WO3 þ nS2O7 2-fC2n-. It is found that n = 1......; therefore, the reaction WO3 þ S2O7 2- f WO2(SO4)2 2- with six-fold W coordination is proposed as fully consistent with the observed Raman features. The effects of the incremental dissolution and presence of K2SO4 inWO3-K2S2O7 melts point to aWO3 3 K2S2O7 3 K2SO4 stoichiometry and a corresponding complex...

Structure-function relationships of Na+, K+, ATP, or Mg2+ binding and energy transduction in Na,K-ATPase

DEFF Research Database (Denmark)

Jorgensen, Peter L.; Pedersen, Per Amstrup

2000-01-01

Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction......Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction...

Crossed molecular beam-tunable laser determination of velocity dependence of intramultiplet mixing: K(4p2P1/2)+He →K(4p2P3/2)+He

International Nuclear Information System (INIS)

Anderson, R.W.; Goddard, T.P.; Parravano, C.; Warner, J.

1976-01-01

The velocity dependence of intramultiplet mixing, K(4p 2 P 1 / 2 ) +He→K(4p 2 P 3 / 2 )+He, has been measured over the relative velocity range v=1.3--3.4 km/sec. The cross section appears to fit a linear function Q (v) =A (v-v 0 ), where a=6.3 x 10 -4 A 2 and v 0 = 7.9 x 10 4 cm/sec. The value of A is obtained by normalization to the literature thermal average cross section. The intramultiplet mixing theory of Nikitin is modified to yield Q (v) for the process. The modified theory correctly exhibits detailed balancing, and it is normalized to provide a very good fit to the observed Q (v). The magnitude of the normalization factor, however, is larger than that predicted from recent pseudopotential calculations of the excited state potentials. The temperature dependence of intramultiplet mixing is predicted. The use of laser polarization to determine the m/subj/ dependence of the process K(4p 2 P 3 / 2 +He→K(4p 2 P 1 / 2 )+He and other collision processes of excited 2 P 3 / 2 states is examined

CHARACTERIZING K2 PLANET DISCOVERIES: A SUPER-EARTH TRANSITING THE BRIGHT K DWARF HIP 116454

International Nuclear Information System (INIS)

Vanderburg, Andrew; Montet, Benjamin T.; Johnson, John Asher; Buchhave, Lars A.; Zeng, Li; Latham, David W.; Angus, Ruth; Bieryla, Allyson; Charbonneau, David; Pepe, Francesco; Udry, Stéphane; Lovis, Christophe; Cameron, Andrew Collier; Molinari, Emilio; Boschin, Walter; Matthews, Jaymie M.; Cameron, Chris; Law, Nicholas; Bowler, Brendan P.; Baranec, Christoph

2015-01-01

We report the first planet discovery from the two-wheeled Kepler (K2) mission: HIP 116454 b. The host star HIP 116454 is a bright (V = 10.1, K = 8.0) K1 dwarf with high proper motion and a parallax-based distance of 55.2 ± 5.4 pc. Based on high-resolution optical spectroscopy, we find that the host star is metal-poor with [Fe/H] =–0.16 ± 0.08 and has a radius R * = 0.716 ± 0.024 R ☉ and mass M * = 0.775 ± 0.027 M ☉ . The star was observed by the Kepler spacecraft during its Two-Wheeled Concept Engineering Test in 2014 February. During the 9 days of observations, K2 observed a single transit event. Using a new K2 photometric analysis technique, we are able to correct small telescope drifts and recover the observed transit at high confidence, corresponding to a planetary radius of R p = 2.53 ± 0.18 R ⊕ . Radial velocity observations with the HARPS-N spectrograph reveal a 11.82 ± 1.33 M ⊕ planet in a 9.1 day orbit, consistent with the transit depth, duration, and ephemeris. Follow-up photometric measurements from the MOST satellite confirm the transit observed in the K2 photometry and provide a refined ephemeris, making HIP 116454 b amenable for future follow-up observations of this latest addition to the growing population of transiting super-Earths around nearby, bright stars

CHARACTERIZING K2 PLANET DISCOVERIES: A SUPER-EARTH TRANSITING THE BRIGHT K DWARF HIP 116454

Energy Technology Data Exchange (ETDEWEB)

Vanderburg, Andrew; Montet, Benjamin T.; Johnson, John Asher; Buchhave, Lars A.; Zeng, Li; Latham, David W.; Angus, Ruth; Bieryla, Allyson; Charbonneau, David [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Pepe, Francesco; Udry, Stéphane; Lovis, Christophe [Observatoire Astronomique de l' Université de Genève, 51 chemin des Maillettes, CH-1290 Versoix (Switzerland); Cameron, Andrew Collier [SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Molinari, Emilio; Boschin, Walter [INAF-Fundación Galileo Galilei, Rambla José Ana Fernández Pérez, 7, E-38712 Breña Baja (Spain); Matthews, Jaymie M. [University of British Columbia, Vancouver, BC V6T1Z1 (Canada); Cameron, Chris [Cape Breton University, 1250 Grand Lake Road, Sydney NS B1P 6L2 (Canada); Law, Nicholas [University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Bowler, Brendan P. [California Institute of Technology, Pasadena, CA 91125 (United States); Baranec, Christoph, E-mail: avanderburg@cfa.harvard.edu [University of Hawai' i at Mānoa, Hilo, HI 96720 (United States); and others

2015-02-10

We report the first planet discovery from the two-wheeled Kepler (K2) mission: HIP 116454 b. The host star HIP 116454 is a bright (V = 10.1, K = 8.0) K1 dwarf with high proper motion and a parallax-based distance of 55.2 ± 5.4 pc. Based on high-resolution optical spectroscopy, we find that the host star is metal-poor with [Fe/H] =–0.16 ± 0.08 and has a radius R {sub *} = 0.716 ± 0.024 R {sub ☉} and mass M {sub *} = 0.775 ± 0.027 M {sub ☉}. The star was observed by the Kepler spacecraft during its Two-Wheeled Concept Engineering Test in 2014 February. During the 9 days of observations, K2 observed a single transit event. Using a new K2 photometric analysis technique, we are able to correct small telescope drifts and recover the observed transit at high confidence, corresponding to a planetary radius of R{sub p} = 2.53 ± 0.18 R {sub ⊕}. Radial velocity observations with the HARPS-N spectrograph reveal a 11.82 ± 1.33 M {sub ⊕} planet in a 9.1 day orbit, consistent with the transit depth, duration, and ephemeris. Follow-up photometric measurements from the MOST satellite confirm the transit observed in the K2 photometry and provide a refined ephemeris, making HIP 116454 b amenable for future follow-up observations of this latest addition to the growing population of transiting super-Earths around nearby, bright stars.

Leaping shampoo glides on a 500-nm-thick lubricating air layer

Science.gov (United States)

Li, Erqiang; Lee, Sanghyun; Marston, Jeremy; Bonito, Andrea; Thoroddsen, Sigurdur

2013-11-01

When a stream of shampoo is fed onto a pool in one's hand, a jet can leap sideways or rebound from the liquid surface in an intriguing phenomenon known as the Kaye effect. Earlier studies have debated whether non-Newtonian effects are the underlying cause of this phenomenon, making the jet glide on top of a shear-thinning liquid layer, or whether an entrained air layer is responsible. Herein we show unambiguously that the jet slides on a lubricating air layer [Lee et al., Phys. Rev. E 87, 061001 (2013)]. We identify this layer by looking through the pool liquid and observing its rupture into fine micro-bubbles. The resulting micro-bubble sizes suggest that the thickness of this air layer is around 500 nm. This thickness estimate is also supported by the tangential deceleration of the jet during the rebounding, with the shear stress within the thin air layer sufficient for the observed deceleration. Particle tracking within the jet shows uniform velocity, with no pronounced shear, which would be required for shear-thinning effects. The role of the surfactant may primarily be to stabilize the air film.

Leap motion evaluation for assessment of upper limb motor skills in Parkinson's disease.

Science.gov (United States)

Butt, A H; Rovini, E; Dolciotti, C; Bongioanni, P; De Petris, G; Cavallo, F

2017-07-01

The main goal of this study is to investigate the potential of the Leap Motion Controller (LMC) for the objective assessment of motor dysfunctioning in patients with Parkinson's disease (PwPD). The most relevant clinical signs in Parkinson's Disease (PD), such as slowness of movements, frequency variation, amplitude variation, and speed, were extracted from the recorded LMC data. Data were clinically quantified using the LMC software development kit (SDK). In this study, 16 PwPD subjects and 12 control healthy subjects were involved. A neurologist assessed the subjects during the task execution, assigning them a score according to the MDS/UPDRS-Section III items. Features of motor performance from both subject groups (patients and healthy controls) were extracted with dedicated algorithms. Furthermore, to find out the significance of such features from the clinical point of view, machine learning based methods were used. Overall, our findings showed the moderate potential of LMC to extract the motor performance of PwPD.

Recent development status of compact 2 K GM cryocoolers

Science.gov (United States)

Bao, Q.; Xu, M. Y.; Tsuchiya, A.; Li, R.

2015-12-01

To meet the growing demand for a compact cooling solution for superconducting electronic devices, we developed a two-stage 2 K GM cryocooler and a cryostat system, which can reach 46.3 K / 2.2 K on the first and second stages under no-load conditions. Nevertheless, with several innovative technologies applied, the total length of the expander cylinder is reduced to under 70% of the smallest conventional 4 K GM cryocooler. In this paper we will present the design method, including material selection and structure design with detailed explanation, which has been confirmed by both simulation and experiment.

CCQM-K11.2 determination of glucose in human serum and CCQM-K12.2 determination of creatinine in human serum

Science.gov (United States)

Wise, Stephen A.; Phinney, Karen W.; Duewer, David L.; Sniegoski, Lorna T.; Welch, Michael J.; Pritchett, Jeanita; Pabello, Guiomar; Avila Calderon, Marco A.; Balderas, Miryan; Qinde, Liu; Kooi, Lee Tong; Rego, Eliane; Garrido, Bruno; Allegri, Gabriella; de La Cruz, Marcia; Barrabin, Juliana; Monteiro, Tânia; Lee, Hwashim; Kim, Byungjoo; Delatour, Vincent; Peignaux, Maryline; Kawaguchi, Migaku; Bei, Xu; Can, Quan; Nammoonnoy, Jintana; Schild, Katrin; Ohlendorf, Rüdiger; Henrion, Andre; Ceyhan Gören, Ahmet; Yılmaz, Hasibe; Bilsel, Mine; Konopelko, L.; Krylov, A.; Lopushanskaya, E.

2018-01-01

Glucose and creatinine are two of the most frequently measured substances in human blood/serum for assessing the health status of individuals. Because of their clinical significance, CCQM-K11 glucose in human serum and CCQM-K12 creatinine in human serum were the fourth and fifth key comparisons (KCs) performed by the Organic Analysis Working Group (OAWG). These KCs were conducted in parallel and were completed in 2001. The initial subsequent KCs for glucose, CCQM-K11.1, and creatinine, CCQM-K12.1, were completed in 2005. Measurements for the next KCs for these two measurands, CCQM-K11.2 and CCQM-K12.2, were completed in 2013. While designed as subsequent KCs, systematic discordances between the participants' and the anchor institution's results in both comparisons lead the OAWG to request reference results from two experienced laboratories that had participated in the 2001 comparisons. Based on the totality of the available information, the OAWG converted both CCQM-K11.2 and CCQM-K12.2 to 'Track C' KCs where the key comparison reference value is estimated by consensus. These comparisons highlighted that carrying out comparisons for complex chemical measurements and expecting to be able to treat them under the approaches used for formal CIPM subsequent comparisons is not an appropriate strategy. The approach used here is a compromise to gain the best value from the comparison; it is not an approach that will be used in the future. Instead, the OAWG will focus on Track A and Track C comparisons that are treated as stand-alone entities. Participation in CCQM-K11.2 demonstrates a laboratory's capabilities to measure a polar (pKow > 2), low molecular mass (100 g/mol to 500 g/mol) metabolite in human serum at relatively high concentrations (0.1 mg/g to 10 mg/g). Participation in CCQM-K12.2 demonstrates capabilities to measure similar classes of metabolites at relatively low concentrations (1 μg/g to 30 μg/g). The capabilities required for the analysis of complex

Beyond the Kepler/K2 bright limit

DEFF Research Database (Denmark)

White, T. R.; Pope, B. J. S.; Antoci, V.

2017-01-01

The most powerful tests of stellar models come from the brightest stars in the sky, for which complementary techniques, such as astrometry, asteroseismology, spectroscopy and interferometry, can be combined. The K2 mission is providing a unique opportunity to obtain high-precision photometric time...... have developed a new photometric technique, which we call halo photometry, to observe very bright stars using a limited number of pixels. Halo photometry is simple, fast and does not require extensive pixel allocation, and will allow us to use K2 and other photometric missions, such as TESS, to observe...... to 2000 ppm. For the star Maia, we demonstrate the utility of combining K2 photometry with spectroscopy and interferometry to show that it is not a 'Maia variable', and to establish that its variability is caused by rotational modulation of a large chemical spot on a 10 d time-scale....

Controllable solvothermal synthesis and photocatalytic properties of complex (oxy)fluorides K{sub 2}TiOF{sub 4}, K{sub 3}TiOF{sub 5}, K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} and K{sub 2}TiF{sub 6}

Energy Technology Data Exchange (ETDEWEB)

Sheng Jie [Division of Nanomaterials and Nanochemistry, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230026 (China); Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China); Tang Kaibin, E-mail: kbtang@ustc.edu.cn [Division of Nanomaterials and Nanochemistry, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230026 (China); Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China); Cheng Wei; Wang Junli; Nie Yanxiang; Yang Qing [Division of Nanomaterials and Nanochemistry, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230026 (China); Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China)

2009-11-15

Complex (oxy)fluorides K{sub 2}TiF{sub 6}, K{sub 2}TiOF{sub 4}, K{sub 3}TiOF{sub 5} and K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} have been successfully synthesized for the first time through a controllable solvothermal route involving different solvents, for example, methanol, methanol-H{sub 2}O and methanol-H{sub 2}O{sub 2}. The as-prepared products were characterized by X-ray powder diffraction, N{sub 2} surface area adsorption, scanning electron microscope, Fourier transform infrared spectroscopy, UV-vis absorption spectra and X-ray fluorescence. The influences of reaction conditions such as the ratio of methanol to H{sub 2}O{sub 2} or methanol to H{sub 2}O, reaction temperature on the phase, crystallizability and purity of the (oxy)fluorides products were discussed in detail. Meanwhile, the photocatalytic behaviors of the as-prepared K{sub 2}TiF{sub 6}, K{sub 2}TiOF{sub 4}, K{sub 3}TiOF{sub 5} and K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} were evaluated by degradation of rhodamine B molecules, and the results showed that all of the products possessed photocatalytic activities in the order of K{sub 2}TiOF{sub 4} > K{sub 2}TiF{sub 6} > K{sub 7}Ti{sub 4}O{sub 4}F{sub 7} > K{sub 3}TiOF{sub 5} at room temperature under the UV light.

Selective Assembly of Na,K-ATPase α2β2 Heterodimers in the Heart

Science.gov (United States)

Habeck, Michael; Tokhtaeva, Elmira; Nadav, Yotam; Ben Zeev, Efrat; Ferris, Sean P.; Kaufman, Randal J.; Bab-Dinitz, Elizabeta; Kaplan, Jack H.; Dada, Laura A.; Farfel, Zvi; Tal, Daniel M.; Katz, Adriana; Sachs, George; Vagin, Olga; Karlish, Steven J. D.

2016-01-01

The Na,K-ATPase α2 subunit plays a key role in cardiac muscle contraction by regulating intracellular Ca2+, whereas α1 has a more conventional role of maintaining ion homeostasis. The β subunit differentially regulates maturation, trafficking, and activity of α-β heterodimers. It is not known whether the distinct role of α2 in the heart is related to selective assembly with a particular one of the three β isoforms. We show here by immunofluorescence and co-immunoprecipitation that α2 is preferentially expressed with β2 in T-tubules of cardiac myocytes, forming α2β2 heterodimers. We have expressed human α1β1, α2β1, α2β2, and α2β3 in Pichia pastoris, purified the complexes, and compared their functional properties. α2β2 and α2β3 differ significantly from both α2β1 and α1β1 in having a higher K0.5K+ and lower K0.5Na+ for activating Na,K-ATPase. These features are the result of a large reduction in binding affinity for extracellular K+ and shift of the E1P-E2P conformational equilibrium toward E1P. A screen of perhydro-1,4-oxazepine derivatives of digoxin identified several derivatives (e.g. cyclobutyl) with strongly increased selectivity for inhibition of α2β2 and α2β3 over α1β1 (range 22–33-fold). Molecular modeling suggests a possible basis for isoform selectivity. The preferential assembly, specific T-tubular localization, and low K+ affinity of α2β2 could allow an acute response to raised ambient K+ concentrations in physiological conditions and explain the importance of α2β2 for cardiac muscle contractility. The high sensitivity of α2β2 to digoxin derivatives explains beneficial effects of cardiac glycosides for treatment of heart failure and potential of α2β2-selective digoxin derivatives for reducing cardiotoxicity. PMID:27624940

LEAP into the Pfizer Global Virtual Library (PGVL) space: creation of readily synthesizable design ideas automatically.

Science.gov (United States)

Hu, Qiyue; Peng, Zhengwei; Kostrowicki, Jaroslav; Kuki, Atsuo

2011-01-01

Pfizer Global Virtual Library (PGVL) of 10(13) readily synthesizable molecules offers a tremendous opportunity for lead optimization and scaffold hopping in drug discovery projects. However, mining into a chemical space of this size presents a challenge for the concomitant design informatics due to the fact that standard molecular similarity searches against a collection of explicit molecules cannot be utilized, since no chemical information system could create and manage more than 10(8) explicit molecules. Nevertheless, by accepting a tolerable level of false negatives in search results, we were able to bypass the need for full 10(13) enumeration and enabled the efficient similarity search and retrieval into this huge chemical space for practical usage by medicinal chemists. In this report, two search methods (LEAP1 and LEAP2) are presented. The first method uses PGVL reaction knowledge to disassemble the incoming search query molecule into a set of reactants and then uses reactant-level similarities into actual available starting materials to focus on a much smaller sub-region of the full virtual library compound space. This sub-region is then explicitly enumerated and searched via a standard similarity method using the original query molecule. The second method uses a fuzzy mapping onto candidate reactions and does not require exact disassembly of the incoming query molecule. Instead Basis Products (or capped reactants) are mapped into the query molecule and the resultant asymmetric similarity scores are used to prioritize the corresponding reactions and reactant sets. All sets of Basis Products are inherently indexed to specific reactions and specific starting materials. This again allows focusing on a much smaller sub-region for explicit enumeration and subsequent standard product-level similarity search. A set of validation studies were conducted. The results have shown that the level of false negatives for the disassembly-based method is acceptable when the

Influence of Co or Ce addition on the NOx storage and sulfur-resistance performance of the lean-burn NOx trap catalyst Pt/K/TiO{sub 2}-ZrO{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Zou Zhiqiang [Tianjin Key Laboratory of Applied Catalysis Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Meng, Ming, E-mail: mengm@tju.edu.cn [Tianjin Key Laboratory of Applied Catalysis Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China); Tsubaki, Noritatsu [Department of Applied Chemistry, School of Engineering, University of Toyama, Gofuku 3190, Toyama city, Toyama 930 8555 (Japan); He Junjun; Wang Gang; Li Xingang; Zhou Xiaoyan [Tianjin Key Laboratory of Applied Catalysis Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 (China)

2009-10-15

The Pt/K/TiO{sub 2}-ZrO{sub 2} catalysts promoted by Co or Ce were prepared by successive impregnation or mechanically mixing method. The influence of Co or Ce addition on the NOx storage and sulfur-resistance performance of the catalyst was investigated carefully. The techniques of XRD, FT-IR, in-situ DRIFTS, H{sub 2}-TPR and XPS were employed for catalyst characterization. The Co or Ce addition can greatly improve the NOx storage capacity of Pt/K/TiO{sub 2}-ZrO{sub 2} due to the enhanced oxidation ability and the release of more K sites. Ce addition induces higher K/Ti atomic ratio and larger NOx storage capacity as compared with Co addition. After sulfation and regeneration, the promoted catalysts shows more or less decreased NSC than Pt/K/TiO{sub 2}-ZrO{sub 2} due to the formation of more sulfates, especially for the Co-promoted catalysts, which possess better oxidation ability and facilitate the formation of large sulfates. The effect of Ce addition on Pt/K/TiO{sub 2}-ZrO{sub 2} largely depends on the addition mode. The high oxidation ability and the high K/Ti ratio of the mechanically prepared Ce-promoted catalyst make it still possess considerable NOx storage capacity (NSC) of 142 {mu}mol/g after sulfation and regeneration. With the decrease of sulfur content in fuels, the Co- and Ce-promoted catalysts possessing large NOx storage capacity, will be applicable to the purification of lean-burn NOx.

Crystal structure investigations of ZrAsxSey (x>y, x+y≤2) by single crystal neutron diffraction at 300 K, 25 K and 2.3 K

International Nuclear Information System (INIS)

Niewa, Rainer; Czulucki, Andreas; Schmidt, Marcus; Auffermann, Gudrun; Cichorek, Tomasz; Meven, Martin; Pedersen, Bjoern; Steglich, Frank; Kniep, Ruediger

2010-01-01

Large single crystals of ZrAs x Se y (x>y, x+y≤2, PbFCl type of structure, space group P4/nmm) were grown by Chemical Transport. Structural details were studied by single crystal neutron diffraction techniques at various temperatures. One single crystal specimen with chemical composition ZrAs 1.595(3) Se 0.393(1) was studied at ambient temperature (R1=5.10 %, wR2=13.18 %), and a second crystal with composition ZrAs 1.420(3) Se 0.560(1) was investigated at 25 K (R1=2.70%, wR2=5.70 %) and 2.3 K (R1=2.30 %, wR2=4.70 %), respectively. The chemical compositions of the crystals under investigation were determined by wavelength dispersive X-ray spectroscopy. The quantification of trace elements was carried out by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry. According to the crystal structure refinements the crystallographic 2a site is occupied by As, together with a significant amount of vacancies. One of the 2c sites is fully occupied by As and Se (random distribution). With respect to the fractional coordinates of the atoms, the crystal structure determinations based on the data obtained at 25.0 K and 2.3 K did not show significant deviations from ambient temperature results. The temperature dependence of the displacement parameters indicates a static displacement of As on the 2a sites (located on the (0 0 1) planes) for all temperatures. No indications for any occupation of interstitial sites or the presence of vacancies on the Zr (2a) site were found. - Graphical abstract: Large single crystals of ZrAs x Se y grown by Chemical Transport to study structural details as the As-Se order scheme by single crystal neutron diffraction.

Don't Gamble with Y2K Compliance.

Science.gov (United States)

Sturgeon, Julie

1999-01-01

Examines one school district's (Clark County, Nevada) response to the Y2K computer problem and provides tips on time-saving Y2K preventive measures other school districts can use. Explains how the district de-bugged its computer system including mainframe considerations and client-server applications. Highlights office equipment and teaching…

The Y2K issue in Sweden

International Nuclear Information System (INIS)

Dahlin, G.; Ek, P.; Isaksson, S.; Ericsson, A.M.; Jaernry, C.

1999-01-01

The paper overviews the work performed in Sweden on the Y2K issue. It describes in summary how the work is done at the utilities, some lessons learned and the work performed by the regulatory body, the Swedish Power Inspectorate. It discusses as well, how the reporting and accountancy has been changed to meet the Y2K problem at the Swedish State Authority as well as at the Swedish nuclear facilities. There is a section describing the Physical Protection issues

Introduction of an Elementary Method to Express $\\zeta(2n+1)$ in Terms of $\\zeta(2k)$ with $k\\geq 1$

OpenAIRE

Fujii, Kazuyuki; Suzuki, Tatsuo

2008-01-01

In this note we give the most elementary method (as far as we know) to express $\\zeta(2n+1)$ in terms of $\\{\\zeta(2k)|k\\geq 1\\}$. The method is based on only some elementary works by Leonhard Euler, so it is very instructive to non-experts or students.

Nevada, the Great Recession, and Education

Science.gov (United States)

Verstegen, Deborah A.

2013-01-01

The impact of the Great Recession and its aftermath has been devastating in Nevada, especially for public education. This article discusses the budget shortfalls and the impact of the economic crisis in Nevada using case study methodology. It provides a review of documents, including Governor Gibbon's proposals for the public K-12 education system…

Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules.

Science.gov (United States)

Kuriyama, Shigeki; Hitomi, Misuzu; Yoshiji, Hitoshi; Nonomura, Takako; Tsujimoto, Tatsuhiro; Mitoro, Akira; Akahane, Takami; Ogawa, Mutsumi; Nakai, Seiji; Deguchi, Akihiro; Masaki, Tsutomu; Uchida, Naohito

2005-08-01

A number of studies have shown that various vitamins K, specifically vitamin K2, possessed antitumor activity on various types of rodent- and human-derived neoplastic cell lines. However, there are only a small number of reports demonstrating in vivo antitumor effects of vitamins K. Furthermore, the mechanism of antitumor effects of vitamins K still remains to be examined. In the present study, we examined the antitumor effects of vitamins K2, K3 and K5 on PLC/PRF/5 human hepatocellular carcinoma (HCC) cells in vivo. Furthermore, to examine the mechanism of antitumor actions of these vitamins K, mRNA expression levels of various G1 phase-related cell cycle molecules were evaluated by using a real-time reverse transcription-polymerase chain reaction (RT-PCR) method. HCC-bearing animals were produced by implanting PLC/PRF/5 cells subcutaneously into athymic nude mice, and drinking water containing vitamin K2, K3 or K5 was given to the animals. Treatments with vitamins K2, K3 and K5 were shown to markedly inhibit the growth of HCC tumors. To examine the mechanism of in vivo antitumor effects of vitamins K, total RNA was extracted from HCC tumors, and the expression of G1 phase-related cell cycle molecules was quantitatively examined. Real-time RT-PCR demonstrated that the expression of the cell cycle-driving molecule, cyclin-dependent kinase 4 (Cdk4), in HCC was significantly reduced by the treatments with vitamin K2, K3 and K5. Conversely, the expression of the cell cycle-suppressing molecules, Cdk inhibitor p16INK4a and retinoblastoma, in HCC was significantly enhanced by the treatments with vitamins K2, K3 and K5. These results indicate that vitamins K2, K3 and K5 exert antitumor effects on HCC by regulating the expression of G1 phase-related cell cycle molecules. These results also indicate that vitamins K2, K3 and K5 may be useful agents for the treatment of patients with HCC.

Full article: The Reaction between MoO3 and Molten K2S2O7 forming K2MoO2(SO4)2

DEFF Research Database (Denmark)

Nørbygaard, Thomas; Berg, Rolf W.; Nielsen, Kurt

1998-01-01

.4540(4), c = 8.8874(3) Å, beta = 112.194(1)o, wR2 = 0.0897 for 3491 independent reflections. The compound, K2MoO2(SO4)2, contains (Mo02)2+ core ions in distorted octahedral coordination, with two short (ca. 1.69 Å) terminal bonds in cis-configuration (the O-Mo-O angle is 103.1(2)o), and with two long (ca. 2...

An oil-in-water self-assembly synthesis, characterization and photocatalytic properties of nano Ag@AgCl surface-sensitized K2Ti4O9

International Nuclear Information System (INIS)

Liang, Yinghua; Lin, Shuanglong; Liu, Li; Hu, Jinshan; Cui, Wenquan

2014-01-01

Highlights: • The plasmatic Ag@AgCl surface-sensitized K 2 Ti 4 O 9 composite photocatalysts. • Ag@AgCl greatly increased visible light absorption for K 2 Ti 4 O 9 . • The photocatalysts exhibited enhanced photocatalytic dye degradation. - Abstract: Nano-sized plasmonic Ag@AgCl surface-sensitized K 2 Ti 4 O 9 composite photocatalysts (hereafter designated as Ag@AgCl/K 2 Ti 4 O 9 ) was synthesized via a facile oil-in-water self-assembly method. The photocatalytic activity of the prepared materials for RhB (Rhodamine B) degradation was examined under visible light irradiation. The results reveal that the size of Ag@AgCl, which evenly dispersed on the surface of K 2 Ti 4 O 9 , distributes about 20–50 nm. The UV–vis diffuse reflectance spectra indicate that Ag@AgCl/K 2 Ti 4 O 9 samples have a significantly enhanced optical absorption in 380–700 nm. The photocatalytic activities of the Ag@AgCl/K 2 Ti 4 O 9 samples increase first and then decrease with increasing amount of loading Ag@AgCl and the Ag@AgCl(20 wt.%)/K 2 Ti 4 O 9 sample exhibits the best photocatalytic activity and 94.47% RhB was degraded after irradiation for 2 h. Additionally, studies performed using radical scavengers indicated that O 2 · − and Cl 0 acted as the main reactive species. The electronic interaction was systematically studied and confirmed by the photo-electrochemical measurements

Affymetrix SNP array data for wild Dutch great tits (Parus major)

NARCIS (Netherlands)

Silva, Da Vinicius; Laine, Veronika N.; Bosse, M.; Oers, C.H.J.; Dibbits, B.W.; Visser, M.E.; Crooijmans, R.P.M.A.; Groenen, M.

2018-01-01

The great tit is a widely studied passerine bird species in ecology that, in the past decades, has provided important insights into speciation, phenology, behavior and microevolution. After completion of the great tit genome sequence, a customized high density 650k SNP array was developed enabling

Experimental determination and modeling of the solubility phase diagram of the ternary system (Li{sub 2}SO{sub 4} + K{sub 2}SO{sub 4} + H{sub 2}O) at 288.15 K

Energy Technology Data Exchange (ETDEWEB)

Wang, Shiqiang, E-mail: wangshiqiang@tust.edu.cn [Tianjin Key Laboratory of Marine Resources and Chemistry, College of Marine Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457 (China); Guo, Yafei [Tianjin Key Laboratory of Marine Resources and Chemistry, College of Marine Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457 (China); Li, Dongchan [Engineering Research Center of Seawater Utilization Technology of Ministry of Education, Hebei University of Technology, Tianjin 300130 (China); Tang, Peng; Deng, Tianlong [Tianjin Key Laboratory of Marine Resources and Chemistry, College of Marine Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457 (China)

2015-02-10

Highlights: • Solubility of the ternary system Li{sub 2}SO{sub 4} + K{sub 2}SO{sub 4} + H{sub 2}O at 288.15 K has been measured. • Phase diagram of this system was simulated and calculated by a thermodynamic model. • Li{sub 2}SO{sub 4}·K{sub 2}SO{sub 4} belongs to the incongruent double salt in this system. • Solution density was calculated using empirical equation. - Abstract: The solubility and density in the thermodynamic phase equilibria ternary system (Li{sub 2}SO{sub 4} + K{sub 2}SO{sub 4} + H{sub 2}O) at 288.15 K and 0.1 MPa were investigated experimentally with the method of isothermal dissolution equilibrium. This system at 288.15 K consists of two invariant points, three univariant isothermal dissolution curves; and three crystallization regions. The salt Li{sub 2}SO{sub 4}·K{sub 2}SO{sub 4} belongs to the incongruent double salt, and no solid solution was found. Based on the Pitzer model and its extended Harvie–Weare (HW) model, the mixing ion-interaction parameters of θ{sub Li,K}, ψ{sub Li,K,SO4} at 288.15 K and the solubility equilibrium constants K{sub sp} of solid phases Li{sub 2}SO{sub 4}·H{sub 2}O and Li{sub 2}SO{sub 4}·K{sub 2}SO{sub 4}, which are not reported in the literature were acquired. A comparison between the calculated and experimental results at 288.15 K for the ternary system shows that the calculated solubilities obtained with the extended HW model agree well with experimental data.

SAFARI optical system architecture and design concept

NARCIS (Netherlands)

Pastor, Carmen; Jellema, Willem; Zuluaga-Ramírez, Pablo; Arrazola, David; Fernández-Rodriguez, M.; Belenguer, Tomás; González Fernández, Luis M.; Audley, Michael D.; Evers, Jaap; Eggens, Martin; Torres Redondo, Josefina; Najarro, Francisco; Roelfsema, P.

2016-01-01

SpicA FAR infrared Instrument, SAFARI, is one of the instruments planned for the SPICA mission. The SPICA mission is the next great leap forward in space-based far-infrared astronomy and will study the evolution of galaxies, stars and planetary systems. SPICA will utilize a deeply cooled 2.5m-class

Cleanup Verification Package for the 116-K-2 Effluent Trench

International Nuclear Information System (INIS)

Capron, J.M.

2006-01-01

This cleanup verification package documents completion of remedial action for the 116-K-2 effluent trench, also referred to as the 116-K-2 mile-long trench and the 116-K-2 site. During its period of operation, the 116-K-2 site was used to dispose of cooling water effluent from the 105-KE and 105-KW Reactors by percolation into the soil. This site also received mixed liquid wastes from the 105-KW and 105-KE fuel storage basins, reactor floor drains, and miscellaneous decontamination activities

J e (4.2?K, 31.2 T) beyond 1?kA/mm2 of a ~3.2??m thick, 20?mol% Zr-added MOCVD REBCO coated conductor

OpenAIRE

Xu, A.; Zhang, Y.; Gharahcheshmeh, M. Heydari; Yao, Y.; Galstyan, E.; Abraimov, D.; Kametani, F.; Polyanskii, A.; Jaroszynski, J.; Griffin, V.; Majkic, G.; Larbalestier, D. C.; Selvamanickam, V.

2017-01-01

A main challenge that significantly impedes REBa2Cu3Ox (RE?=?rare earth) coated conductor applications is the low engineering critical current density J e because of the low superconductor fill factor in a complicated layered structure that is crucial for REBa2Cu3Ox to carry supercurrent. Recently, we have successfully achieved engineering critical current density beyond 2.0?kA/mm2 at 4.2?K and 16 T, by growing thick REBa2Cu3Ox layer, from ?1.0??m up to ?3.2??m, as well as controlling the pin...

Immunomodulatory effect of vitamin K2: Implications for bone health.

Science.gov (United States)

Myneni, V D; Mezey, E

2018-03-01

In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non-vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T-cell suppression by vitamin K2. Peripheral blood mononuclear cells (PBMCs) from three healthy donors were used. The PBMCs were stimulated with the mitogens phytohemagglutinin and concanavalin A, and T-cell proliferation was analyzed using flow cytometry based on carboxyfluorescein succinimidyl ester (CSFE) dye dilution. Vitamin K2 (60 and 100 μM) inhibited T-cell proliferation. Vitamin K1 at the same concentrations did not inhibit T-cell proliferation. Vitamin K2 has immunomodulatory activities. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

Measurements of hadron yields from the T2K replica target in the NA61/SHINE experiment for neutrino flux prediction in T2K

CERN Document Server

AUTHOR|(CDS)2086777

T2K is an accelerator-based long-baseline neutrino experiment in Japan. The main goal of the T2K experiment is a search for CP violation in the lepton sector by measuring electron (anti)neutrino appearance in a muon (anti)neutrino beam. Initial (anti)neutrino flux is produced in decays of hadrons which originate from the interactions and the re-interactions of a $30\\:$GeV proton beam with a $90\\:$cm long graphite target. Knowledge of the T2K neutrino flux is limited due to large hadron production uncertainties. A series of hadron production measurements were done to solve this problem, in the NA61/SHINE experiment at CERN. Measurements were performed with a proton beam and two target types: a thin graphite target and a replica of the T2K target. Work presented in this thesis concentrates on the T2K replica target data taken in 2010 and the development of the analysis and calibration software. The aim of these measurements is to fully constrain production of $\\pi^+$, $\\pi^-$, $K^+$, $K^-$ and $p$ coming from t...

UNION-K 2.0 User's Manual

Energy Technology Data Exchange (ETDEWEB)

Yoo, Jae Woon; Jang, Jin Wook; Kim, Yeong Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2008-12-15

The unified Input/Output processor UNION-K(UNified Input/Output Processor for Neutronics Analysis by K-CORE) has been developed to provide the automatic input file generation and output processing for the fast reactor core analysis. UNION-K includes the material database for reactor analysis and produces the input files for effective cross section generation, core analysis, and reactivity coefficient calculations. UNION-K can execute corresponding core analysis module and edit core performance parameters from the outputs. UNION-K also provides the graphical interface to check the geometrical arrangement of core and fuel sub-assembly and produces the picture files that can be used for reporting. This report has been prepared for instruction of using UNION-K Ver. 2.0 with examples.

Summary of ISNP2K

Indian Academy of Sciences (India)

by medium energy reactions, 3) exotic nuclei with large isospin, large A, high J and high Ex, 4) new dynamical properties of many body nucleon systems, 5) neutrino nuclear physics and neutrons for astroparticle physics, and 6) new accelerators and new applications. ISNP2K with extensive discussions on nuclear physics ...

Noosphere: Does the Internet Provide an Evolutionary Leap to a Higher Level of Collective Intelligence?

Directory of Open Access Journals (Sweden)

Tatjana Milivojević

2015-09-01

Full Text Available The neologism noosphere signifies global human consciousness. According to T. de Chardin, it is the third stage in the development of the earth, after the geosphere and the biosphere. As well as the emergence of life has fundamentally changed the geosphere, the emergence of human consciousness has fundamentally changed the biosphere. De Chardin envisioned the “planetarization” of mankind, which is equivalent to the current globalization by information technology. From an anthropological point of view, internet is not a technology or media as others: it has the potential to revolutionize the current civilizational paradigm. With the advent of the internet the idea of the noosphere has been reactualized and related to the concept of collective intelligence. The article questions the hypothesis of an evolutionary leap in a greater collective intelligence or higher level of collective consciousness presenting pros and cons.

The short-circuit test results of 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer

International Nuclear Information System (INIS)

Tomioka, A.; Otonari, T.; Ogata, T.; Iwakuma, M.; Okamoto, H.; Hayashi, H.; Iijima, Y.; Saito, T.; Gosho, Y.; Tanabe, K.; Izumi, T.; Shiohara, Y.

2011-01-01

The 6.9 kV/2.3 kV 400 kVA-class single-phase YBCO model transformer with the YBCO tape with copper tape was manufactured for short-circuit current test. Short-circuit test was performed and the short-circuit current of primary winding was 346 A which was about six times larger than the rated current. The I-V characteristics of the winding did not change before and after the test. The transformer withstood short-circuit current. We are planning to turn the result into a consideration of a 66 kV/6.9 kV-20 MVA-class three-phase superconducting transformer. We are developing an elemental technology for 66 kV/6.9 kV 20 MVA-class power transformer with YBCO conductors. The protection of short-circuit technology is one of the elemental technologies for HTS transformer. Since short-circuit current is much higher than critical current of YBCO tape, there is a possibility that superconducting characteristics may be damaged during short-circuit period. We made a conductor to compose the YBCO tape with copper tape. We manufactured 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer using this conductor and performed short-circuit current test. The short-circuit current of primary winding was 346 A which was about six times larger than the rated current. The I-V characteristics of the winding did not change before and after the test. We may consider this conductor withstands short-circuit current.

Extended Aperture Photometry of K2 RR Lyrae stars

Science.gov (United States)

Plachy, Emese; Klagyivik, Péter; Molnár, László; Sódor, Ádám; Szabó, Róbert

2017-10-01

We present the method of the Extended Aperture Photometry (EAP) that we applied on K2 RR Lyrae stars. Our aim is to minimize the instrumental variations of attitude control maneuvers by using apertures that cover the positional changes in the field of view thus contain the stars during the whole observation. We present example light curves that we compared to the light curves from the K2 Systematics Correction (K2SC) pipeline applied on the automated Single Aperture Photometry (SAP) and on the Pre-search Data Conditioning Simple Aperture Photometry (PDCSAP) data.

Measuring patchy reionization with kSZ2-21 cm correlations

Science.gov (United States)

Ma, Q.; Helgason, K.; Komatsu, E.; Ciardi, B.; Ferrara, A.

2018-05-01

We study cross-correlations of the kinetic Sunyaev-Zel'dovich effect (kSZ) and 21 cm signals during the epoch of reionization (EoR) to measure the effects of patchy reionisation. Since the kSZ effect is proportional to the line-of-sight velocity, the kSZ-21 cm cross correlation suffers from cancellation at small angular scales. We thus focus on the correlation between the kSZ-squared field (kSZ2) and 21 cm signals. When the global ionization fraction is low (xe ≲ 0.7), the kSZ2 fluctuation is dominated by rare ionized bubbles, which leads to an anticorrelation with the 21 cm signal. When 0.8 ≲ xe primary cosmic microwave background (CMB) anisotropy. The expected signal-to-noise ratios for a ˜10-h integration of upcoming Square Kilometre Array data cross-correlated with maps from the current generation of CMB observatories with 3.4μK arcmin noise and 1.7 arcmin beam over 100 deg2 are 51, 60, and 37 for xe = 0.2, 0.5, and 0.9, respectively.

Spectroscopic properties of K5Li2UF10

International Nuclear Information System (INIS)

Karbowiak, M.; Gajek, Z.; Drozdzynski, J.

2005-01-01

A new uranium (III) fluoro-complex of the formula K 5 Li 2 UF 10 has been synthesised and characterised by X-ray powder diffraction and electronic absorption spectra measurements. The compound crystallises in the orthorhombic system, space group Pnma, with a = 20.723, b = 7.809, c = 6.932 A, V = 1121.89 A 3 , Z = 4 and is isostructural with its K 5 Li 2 NdF 10 and K 5 Li 2 LaF 10 analogous. The absorption spectrum of a polycrystalline sample of K 5 Li 2 UF 10 was recorded at 4.2 K in the 3500-45,000 cm -1 range and is discussed. The observed crystal-field levels were assigned and fitted to parameters of the simplified angular overlap model (AOM) and next to those of a semi-empirical Hamiltonian, which was representing the combined atomic and one-electron crystal-field interactions. The starting values of the AOM parameters were obtained from ab initio calculations. The analysis of the spectra enabled the assignment of 71 crystal-field levels of U 3+ with a relatively small r.m.s. deviation of 37 cm -1 . The total splitting of 714 cm -1 was calculated for the 4 I 9/2 ground multiplet

Spectroscopic properties of K 5Li 2UF 10

Science.gov (United States)

Karbowiak, M.; Gajek, Z.; Drożdżyński, J.

2005-04-01

A new uranium (III) fluoro-complex of the formula K 5Li 2UF 10 has been synthesised and characterised by X-ray powder diffraction and electronic absorption spectra measurements. The compound crystallises in the orthorhombic system, space group Pnma, with a = 20.723, b = 7.809, c = 6.932 Å, V = 1121.89 Å 3, Z = 4 and is isostructural with its K 5Li 2NdF 10 and K 5Li 2LaF 10 analogous. The absorption spectrum of a polycrystalline sample of K 5Li 2UF 10 was recorded at 4.2 K in the 3500-45,000 cm -1 range and is discussed. The observed crystal-field levels were assigned and fitted to parameters of the simplified angular overlap model (AOM) and next to those of a semi-empirical Hamiltonian, which was representing the combined atomic and one-electron crystal-field interactions. The starting values of the AOM parameters were obtained from ab initio calculations. The analysis of the spectra enabled the assignment of 71 crystal-field levels of U 3+ with a relatively small r.m.s. deviation of 37 cm -1. The total splitting of 714 cm -1 was calculated for the 4I 9/2 ground multiplet.

Piezoelectric ceramic material, containing PbNb2O6, K2Nb2O6

International Nuclear Information System (INIS)

Fesenko, E.G.; Filip'ev, V.S.; Razumovskaya, O.N.; Cherner, Ya.E.; Rudkovskaya, L.M.; Zav'yalov, V.P.; Molchanova, R.A.; Kryshtop, V.G.; Panich, A.E.; Servuli, V.A.

1984-01-01

A new piezoelectric ceramic material including PbNb 2 O 6 , K 2 Nb 2 O 6 is prepared. Above the new material contains Nb 2 O 5 . The invention relates to piezotechnique. The principal advantage of this material for acoustic converters is high anisotropy of piezoelectric properties as well as high Curie temperature (T C =539-553 deg C). The composition containing 93.96 mole% PbNb 2 O 6 ; 2.48 mole% K 2 Nb 2 O 6 and 3.56 mole% Nb 2 O 5 has optimum content of parameters

Plasmid transferability of KPC into a virulent K2 serotype Klebsiella pneumoniae.

Science.gov (United States)

Siu, Leung-Kei Kristopher; Huang, David B; Chiang, Tom

2014-03-31

KPC-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are associated with high mortality; however, their virulence determinants are not well defined. We investigated the virulence and plasmid transferability among KPC-containing K. pneumoniae isolates. KPC-2 and -3 were successfully conjugated and retained by a virulent K2 K. pneumoniae recipient isolate. Antimicrobial susceptibility testing showed KPC-2 and -3 donor strains were resistant to more than four classes of antibiotics while the K2 isolate was only initially resistant to ampicillin. After conjugation of KPC-2 and -3, the K2 K. pneumoniae transconjugants became resistant to all beta-lactams. Additionally, the KPC K2 K. pneumoniae transconjugants continued to retain its high serum resistance and murine lethality. Conjugation and retainment of KPC by virulent K2 K. pneumoniae and the ability of the tranconjugants to maintain its high serum resistance and murine lethality after conjugation was demonstrated in this study. These findings are concerning for the potential of KPC-like genes to disseminate among virulent K. pneumoniae isolates.

303-K Storage Facility closure plan. Revision 2

Energy Technology Data Exchange (ETDEWEB)

1993-12-15

Recyclable scrap uranium with zircaloy-2 and copper silicon alloy, uranium-titanium alloy, beryllium/zircaloy-2 alloy, and zircaloy-2 chips and fines were secured in concrete billets (7.5-gallon containers) in the 303-K Storage Facility, located in the 300 Area. The beryllium/zircaloy-2 alloy and zircaloy-2 chips and fines are designated as mixed waste with the characteristic of ignitability. The concretion process reduced the ignitability of the fines and chips for safe storage and shipment. This process has been discontinued and the 303-K Storage Facility is now undergoing closure as defined in the Resource Conservation and Recovery Act (RCRA) of 1976 and the Washington Administrative Code (WAC) Dangerous Waste Regulations, WAC 173-303-040. This closure plan presents a description of the 303-K Storage Facility, the history of materials and waste managed, and the procedures that will be followed to close the 303-K Storage Facility. The 303-K Storage Facility is located within the 300-FF-3 (source) and 300-FF-5 (groundwater) operable units, as designated in the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) (Ecology et al. 1992). Contamination in the operable units 300-FF-3 and 300-FF-5 is scheduled to be addressed through the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 remedial action process. Therefore, all soil remedial action at the 304 Facility will be conducted as part of the CERCLA remedial action of operable units 300-FF-3 and 300-FF-5.

Distribution of vitamin K2 in subchondral bone in osteoarthritic knee joints.

Science.gov (United States)

Ishii, Yoshinori; Noguchi, Hideo; Takeda, Mitsuhiro; Sato, Junko; Yamamoto, Noriaki; Wakabayashi, Hiroyuki; Kanda, Junkichi; Toyabe, Shin-ichi

2013-08-01

Vitamin K may have multiple effects on articular cartilage and subchondral bone that could modulate the pathogenesis of osteoarthritis (OA). The purpose of this study was to evaluate the distribution of vitamin K2 in harvested bones obtained during total knee arthroplasty in knee OA patients. High-performance liquid chromatography was used to measure vitamin K2 in harvested bones obtained during 58 TKA procedures. Vitamin K2 levels were analysed in the medial (FM) and lateral (FL) femoral condyles and in the medial (TM) and lateral (TL) tibial condyles. There was significantly more vitamin K2 in the lateral femoral and tibial condyles than in the corresponding medial condyles (FL vs. FM, p K2 in the FL than in the TL (p = 0.003), and in the FM, vitamin K2 levels were higher than those of the TM, although this was not significant (n.s.). There were no significant differences in vitamin K2 levels in men versus women nor was there a significant correlation with age. This study suggested that vitamin K2 might affect bone turnover since medial condyles showing advanced OA had lower vitamin K2 levels, while lateral condyles showing less advanced OA contained more vitamin K2. Gender and age were not correlated with vitamin K2 localization. All cases had Grade IV OA, and this study suggested that OA grade might be important in controlling the vitamin K2 levels in human bones.

Management of Y2K at the AECB

International Nuclear Information System (INIS)

Hessel, P.

1999-01-01

Activities concerning the Y2K compliance began in 1997 at the AECB. The first activities were oriented towards power reactors. The divisions dealing with other licensees and safeguards have progressively addressed the problem. The AECB has developed a comprehensive strategy on the Y2K problem, and taken actions to see that its own systems and those of its licensees are corrected if needed

KEY COMPARISON: CCT-K2.1: NRC/VNIIFTRI bilateral comparison of capsule-type standard platinum resistance thermometers from 13.8 K to 273.16 K

Science.gov (United States)

Hill, K. D.; Steele, A. G.; Dedikov, Y. A.; Shkraba, V. T.

2005-01-01

The Consultative Committee for Thermometry Key Comparison 2 (CCT-K2) results were published two years ago (2002 Metrologia 39 551-71). NRC served as the pilot laboratory for CCT-K2 and remains able to provide a scale and measurement system suitable for performing bilateral comparisons linked to the original key comparison results. In March 2003, measurements of two VNIIFTRI 100 Ω capsule-style platinum resistance thermometers (CSPRTs), S/N 356 and 476, were undertaken to relate their local calibration to the results from the CCT-K2 exercise. The NRC Leeds and Northrup (L&N) CSPRT S/N 1872174 provides the link to the CCT-K2 results. The three CSPRTs were compared at the eight defining cryogenic temperatures of the International Temperature Scale of 1990 (ITS-90) in the range from 13.8033 K to 273.16 K. The reader is referred to the full text of the CCT-K2 report for a detailed explanation of the methodology employed for the comparison. Only the details unique to the measurements reported here will be addressed in this article. The NRC/VNIIFTRI bilateral comparison of capsule-style platinum resistance thermometers over the range 13.8 K to 273.16 K has revealed calibrations at VNIIFTRI to be in agreement with the KCRV of CCT-K2 within the expanded uncertainty for all temperatures of the comparison with the exception of the triple point of hydrogen at 13.8033 K. One of the two CSPRTs supplied by VNIIFTRI was found to be discrepant as revealed by differences at the triple point of water and at the lowest temperatures of the comparison, and was therefore excluded from further analysis. The linkage to the CCT-K2 data supports the evaluation of the VNIIFTRI CMCs in Appendix C of the KCDB. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCT, according to the provisions

eXpression2Kinases (X2K) Web: linking expression signatures to upstream cell signaling networks.

Science.gov (United States)

Clarke, Daniel J B; Kuleshov, Maxim V; Schilder, Brian M; Torre, Denis; Duffy, Mary E; Keenan, Alexandra B; Lachmann, Alexander; Feldmann, Axel S; Gundersen, Gregory W; Silverstein, Moshe C; Wang, Zichen; Ma'ayan, Avi

2018-05-25

While gene expression data at the mRNA level can be globally and accurately measured, profiling the activity of cell signaling pathways is currently much more difficult. eXpression2Kinases (X2K) computationally predicts involvement of upstream cell signaling pathways, given a signature of differentially expressed genes. X2K first computes enrichment for transcription factors likely to regulate the expression of the differentially expressed genes. The next step of X2K connects these enriched transcription factors through known protein-protein interactions (PPIs) to construct a subnetwork. The final step performs kinase enrichment analysis on the members of the subnetwork. X2K Web is a new implementation of the original eXpression2Kinases algorithm with important enhancements. X2K Web includes many new transcription factor and kinase libraries, and PPI networks. For demonstration, thousands of gene expression signatures induced by kinase inhibitors, applied to six breast cancer cell lines, are provided for fetching directly into X2K Web. The results are displayed as interactive downloadable vector graphic network images and bar graphs. Benchmarking various settings via random permutations enabled the identification of an optimal set of parameters to be used as the default settings in X2K Web. X2K Web is freely available from http://X2K.cloud.

Design and evaluation of an augmented reality simulator using leap motion.

Science.gov (United States)

Wright, Trinette; de Ribaupierre, Sandrine; Eagleson, Roy

2017-10-01

Advances in virtual and augmented reality (AR) are having an impact on the medical field in areas such as surgical simulation. Improvements to surgical simulation will provide students and residents with additional training and evaluation methods. This is particularly important for procedures such as the endoscopic third ventriculostomy (ETV), which residents perform regularly. Simulators such as NeuroTouch, have been designed to aid in training associated with this procedure. The authors have designed an affordable and easily accessible ETV simulator, and compare it with the existing NeuroTouch for its usability and training effectiveness. This simulator was developed using Unity, Vuforia and the leap motion (LM) for an AR environment. The participants, 16 novices and two expert neurosurgeons, were asked to complete 40 targeting tasks. Participants used the NeuroTouch tool or a virtual hand controlled by the LM to select the position and orientation for these tasks. The length of time to complete each task was recorded and the trajectory log files were used to calculate performance. The resulting data from the novices' and experts' speed and accuracy are compared, and they discuss the objective performance of training in terms of the speed and accuracy of targeting accuracy for each system.

Design and evaluation of an augmented reality simulator using leap motion

Science.gov (United States)

de Ribaupierre, Sandrine; Eagleson, Roy

2017-01-01

Advances in virtual and augmented reality (AR) are having an impact on the medical field in areas such as surgical simulation. Improvements to surgical simulation will provide students and residents with additional training and evaluation methods. This is particularly important for procedures such as the endoscopic third ventriculostomy (ETV), which residents perform regularly. Simulators such as NeuroTouch, have been designed to aid in training associated with this procedure. The authors have designed an affordable and easily accessible ETV simulator, and compare it with the existing NeuroTouch for its usability and training effectiveness. This simulator was developed using Unity, Vuforia and the leap motion (LM) for an AR environment. The participants, 16 novices and two expert neurosurgeons, were asked to complete 40 targeting tasks. Participants used the NeuroTouch tool or a virtual hand controlled by the LM to select the position and orientation for these tasks. The length of time to complete each task was recorded and the trajectory log files were used to calculate performance. The resulting data from the novices' and experts' speed and accuracy are compared, and they discuss the objective performance of training in terms of the speed and accuracy of targeting accuracy for each system. PMID:29184667

The Ignalina NPP and Y2K Problem

International Nuclear Information System (INIS)

Medeliene, D.

2000-01-01

Work on preparing the hardware and software of the Ignalina NPP for the year 2000 was started in December 1998. First of all, a Y2K project team was formed comprising 29 specialists. Some of these are the most experienced computer specialist, others co-ordinate work on the Y2K problem at the divisions of the NPP using computers or microprocessors. The project head was appointed and the schedule of work confirmed. In accordance with the schedule, the work was divided into twelve stages. The results showed that the preparations were adequate. On the New Year night the specialists of the Ignalina NPP Emergency Operation Centre worked together with the managers of the plant. Relation with other Lithuanian and international organisations was established. No any Y2K related event happened

Integral Representation of the Pictorial Proof of Sum of [superscript n][subscript k=1]k[superscript 2] = 1/6n(n+1)(2n+1)

Science.gov (United States)

Kobayashi, Yukio

2011-01-01

The pictorial proof of the sum of [superscript n][subscript k=1] k[superscript 2] = 1/6n(n+1)(2n+1) is represented in the form of an integral. The integral representations are also applicable to the sum of [superscript n][subscript k-1] k[superscript m] (m greater than or equal to 3). These representations reveal that the sum of [superscript…

Financial prep for Y2K.

Science.gov (United States)

Lewis, A G; Weingart, V S

1999-01-01

The financial impact of Y2K will be significant and, in some cases, devastating. Careful analysis will help health care organizations prepare for all contingencies and set aside the necessary resources to become compliant.

Observation of $\\overline{B}^0_s \\to J/\\psi f'_2(1525)$ in $J/\\psi K^+K^-$ final states

CERN Document Server

Aaij, R; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amhis, Y; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Arrabito, L; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Bailey, D S; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, C; Bauer, Th; Bay, A; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chiapolini, N; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Collins, P; Comerma-Montells, A; Constantin, F; Contu, A; Cook, A; Coombes, M; Corti, G; Cowan, G A; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Capua, S; De Cian, M; De Lorenzi, F; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisele, F; Eisenhardt, S; Ekelhof, R; Eklund, L; Elsasser, Ch; Elsby, D; Esperante Pereira, D; Estève, L; Falabella, A; Fanchini, E; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauvin, N; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Haefeli, G; Haen, C; Haines, S C; Hampson, T; Hansmann-Menzemer, S; Harji, R; Harnew, N; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Holubyev, K; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Huston, R S; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Knecht, M; Koppenburg, P; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kruzelecki, K; Kucharczyk, M; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, L; Li Gioi, L; Lieng, M; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Malde, S; Mamunur, R M D; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Maynard, B; Mazurov, A; McGregor, G; McNulty, R; Meissner, M; Merk, M; Merkel, J; Messi, R; Miglioranzi, S; Milanes, D A; Minard, M-N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Musy, M; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Nedos, M; Needham, M; Neufeld, N; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palacios, J; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Paterson, S K; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petrella, A; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pie Valls, B; Pietrzyk, B; Pilař, T; Pinci, D; Plackett, R; Playfer, S; Plo Casasus, M; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Rinnert, K; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodrigues, F; Rodriguez Perez, P; Rogers, G J; Roiser, S; Romanovsky, V; Rosello, M; Rouvinet, J; Ruf, T; Ruiz, H; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santinelli, R; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schleich, S; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, A C; Smith, N A; Smith, E; Sobczak, K; Soler, F J P; Solomin, A; Soomro, F; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Topp-Joergensen, S; Torr, N; Tournefier, E; Tran, M T; Tsaregorodtsev, A; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urquijo, P; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Viaud, B; Videau, I; Vilasis-Cardona, X; Visniakov, J; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Voss, H; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Witzeling, W; Wotton, S A; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yushchenko, O; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhong, L; Zverev, E; Zvyagin, A

2012-01-01

In this Letter the decay $\\overline{B}^0_s \\to J/\\psi K^+ K^-$ is investigated. Although the $J/\\psi \\phi$ channel is well known, final states at higher $K^+K^-$ masses have not previously been studied. In the $K^+K^-$ mass spectrum we observe a significant signal in the $f'_2(1525)$ region as well as a non-resonant component. The ratio of the rate in a $K^+K^-$ mass window of $\\pm 125$ MeV around the $f'_2$ relative to that in the $J/\\psi \\phi$ decay, where $\\phi \\to K^+K^-$, is $R=(19.4 \\pm 1.8 \\pm 1.0)$%. Our sample consists of $0.16$ fb$^{-1}$ collected with the LHCb detector using 7 TeV $pp$ collisions.

Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice.

Science.gov (United States)

Kim, Misung; Na, Woori; Sohn, Cheongmin

2013-09-01

Several reports suggest that obesity is a risk factor for osteoporosis. Vitamin K plays an important role in improving bone metabolism. This study examined the effects of vitamin K1 and vitamin K2 supplementation on the biochemical markers of bone turnover and morphological microstructure of the bones by using an obese mouse model. Four-week-old C57BL/6J male mice were fed a 10% fat normal diet group or a 45% kcal high-fat diet group, with or without 200 mg/1000 g vitamin K1 (Normal diet + K1, high-fat diet + K1) and 200 mg/1000 g vitamin K2 (Normal diet + K2, high-fat diet + K2) for 12 weeks. Serum levels of osteocalcin were higher in the high-fat diet + K2 group than in the high-fat diet group. Serum OPG level of the high-fat diet group, high-fat diet + K1 group, and high-fat diet + K2 group was 2.31 ± 0.31 ng/ml, 2.35 ± 0.12 ng/ml, and 2.90 ± 0.11 ng/ml, respectively. Serum level of RANKL in the high-fat diet group was significantly higher than that in the high-fat diet + K1 group and high-fat diet + K2 group (p<0.05). Vitamin K supplementation seems to tend to prevent bone loss in high-fat diet induced obese state. These findings suggest that vitamin K supplementation reversed the high fat diet induced bone deterioration by modulating osteoblast and osteoclast activities and prevent bone loss in a high-fat diet-induced obese mice.

Potassium vanadate K0.23V2O5 as anode materials for lithium-ion and potassium-ion batteries

Science.gov (United States)

Liu, Cailing; Luo, Shaohua; Huang, Hongbo; Wang, Zhiyuan; Wang, Qing; Zhang, Yahui; Liu, Yanguo; Zhai, Yuchun; Wang, Zhaowen

2018-06-01

A layered potassium vanadate K0.23V2O5 has been successfully prepared by the hydrothermal method and evaluated as an anode material for lithium-ion and potassium-ion batteries. High structural stability is demonstrated by the ex situ X-ray diffraction (XRD) and ex situ scanning electron microscopy (SEM). When used as an anode material for lithium-ion batteries, the K0.23V2O5 exhibits a reversible capacity of 480.4 mAh g-1 at 20 mA g-1 after 100 cycles and 439.7 mAh g-1 at 200 mA g-1 after 300 cycles as well as good cycling stability. Even at a high current density of 800 mA g-1, a high reversible capacity of 202.5 mAh g-1 can be retained, indicating excellent rate performance. Whereas in potassium-ion batteries, it retains a capacity of 121.6 mAh g-1 after 150 cycles at 20 mA g-1 and 97.6 mAh g-1 at 100 mA g-1 after 100 cycles. Such superior electrochemical performance of K0.23V2O5 can be ascribed to the special flower-like morphology and structure. Overall, the results highlight the great potential of K0.23V2O5 as an anode material for both lithium-ion and potassium-ion batteries.

The ghost of Afrikaner identity in Ancestral voices, Leap year and The long silence of Mario Salviati (Etienne van Heerden

Directory of Open Access Journals (Sweden)

Mariëtte van Graan

2017-04-01

Full Text Available Ghost characters are a characteristic of the novels of Etienne van Heerden, but little research has been done concerning the nature and function of these ghost characters. In this article I discuss Van Heerden’s use of ghost characters diachronically with reference to the novels Ancestral voices (1986, Leap year (1993 and The long silence of Mario Salviati (2000. In order to clarify the nature of these ghosts, I use the so-called science of the paranormal as a framework. The ghosts in the three novels will be classified accordingly, and then discussed within the context of the novels in which they appear. In this way, I shall show how the ghost characters in these novels can be read as a constantly changing embodiment of Afrikaner identity (a central theme in Van Heerden’s oeuvre. Van Heerden’s Afrikaner changes with the times: in Ancestral voices the ghost characters form a collective that represents a fragmented image of the stereotypical, archaic male Afrikaner identity; in Leap year a liminal character is written in a liminal time to embody a liminal Afrikaner identity; and in The long silence of Mario Salviati Van Heerden moves away from the exclusive Afrikaner identity to a broader South African identity by using ghost characters from very different backgrounds and origins. In conclusion I shall compare these identities and the historical contexts of these novels in order to show the function of Van Heerden’s ghost characters as constant rewritings of South African identities.

Thermodynamic properties and behaviour of A2[(UO2)(MoO4)2] compounds with A = Li, Na, K, Rb, and Cs

International Nuclear Information System (INIS)

Lelet, Maxim I.; Suleimanov, Evgeny V.; Golubev, Aleksey V.; Geiger, Charles A.; Depmeier, Wulf; Bosbach, Dirk; Alekseev, Evgeny V.

2014-01-01

Highlights: • Low temperature heat capacity of A 2 [(UO 2 )(MoO 4 ) 2 ] (A = Li, Na, K, Rb, and Cs) series was determined. • Enthalpy of formation of Li 2 [(UO 2 )(MoO 4 ) 2 ] was determined by HF solution calorimetry. • Δ f G° (T = 298 K) of all phases from studied series were calculated. - Abstract: A thermodynamic investigation of five alkali-metal uranyl molybdates of the general formula A 2 [(UO 2 )(MoO 4 ) 2 ], where A = Li, Na, K, Rb, and Cs, was undertaken. The various phases were synthesized by solid-state reaction of ANO 3, with A = Li, Na, K, Rb, or Cs, MoO 3 and γ-UO 3 . The synthetic products were characterized by X-ray powder diffraction and X-ray fluorescence methods. The low-temperature heat capacity, S r °, was measured using adiabatic calorimetry from T = (6 to 335) K. Based on these data, the third law entropy at T = 298.15 K, S°, is (345 ± 1) J · K −1 · mol −1 for Li 2 [(UO 2 )(MoO 4 ) 2 ], (373 ± 1) J · K −1 · mol −1 for Na 2 [(UO 2 )(MoO 4 ) 2 ], (390 ± 1) J · K −1 · mol −1 for K 2 [(UO 2 )(MoO 4 ) 2 ], (377 ± 1) J · K −1 · mol −1 for Rb 2 [(UO 2 )(MoO 4 ) 2 ] and (394 ± 1) J · K −1 · mol −1 for Cs 2 [(UO 2 )(MoO 4 ) 2 ]. The enthalpy of formation of Li 2 [(UO 2 )(MoO 4 ) 2 ] was determined using HF solution calorimetry giving Δ f H°(T = 298 K, Li 2 [(UO 2 )(MoO 4 ) 2 ], cr) = −(3456 ± 9) kJ · mol −1 . Using these new experimental results, together with literature data, the Gibbs free energy of formation of each compound was calculated, giving: Δ f G°(T = 298 K, Li 2 [(UO 2 )(MoO 4 ) 2 ], cr) = −(3204 ± 9) kJ · mol −1 , Δ f G°(T = 298 K, Na 2 [(UO 2 )(MoO 4 ) 2 ], cr) = −(3243 ± 2) kJ · mol −1 , Δ f G°(T = 298 K, K 2 [(UO 2 )(MoO 4 ) 2 ], cr) = −(3269 ± 3) kJ · mol −1 , Δ f G°(T = 298 K, Rb 2 [(UO 2 )(MoO 4 ) 2 ], cr) = −(3262 ± 3) kJ · mol −1 , and Δ f G°(T = 298 K, Cs 2 [(UO 2 )(MoO 4 ) 2 ], cr) = −(3259 ± 3) kJ · mol −1 . Smoothed S r °(T) values

Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Klebsiella pneumoniae Serotypes K1 and K2.

Science.gov (United States)

Siu, L Kristopher; Tsai, Yu-Kuo; Lin, Jung-Chung; Chen, Te-Li; Fung, Chang-Phone; Chang, Feng-Yee

2016-12-01

In this study, a novel colloidal gold-based immunochromatographic strip (ICS) containing anti-Klebsiella pneumoniae capsular polysaccharide polyclonal antibodies was developed to specifically detect K. pneumoniae serotypes K1 and K2. Capsular polysaccharide K1 and K2 antigens were first used to produce polyclonal anti-K1 and anti-K2 antibodies. Reference strains with different serotypes, nontypeable K. pneumoniae strains, and other bacterial species were then used to assess the sensitivity and specificity of these test strips. The detection limit was found to be 10 5 CFU, and the ICSs were stable for 6 months when stored at room temperature. No false-positive or false-negative results were observed, and equivalent results were obtained compared to those of more conventional test methods, such as PCR or serum agglutination. In conclusion, the ICS developed here requires no technical expertise and allows for the specific, rapid, and simultaneous detection of K. pneumoniae serotypes K1 and K2. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Y2K Survey Results: Counties, Cities, School Districts.

Science.gov (United States)

Petro, Jim

Survey data obtained in recent audits updated Ohio's local government units' assessment of Year 2000 (Y2K) readiness. The survey was developed with three intended objectives: (1) to provide an accurate assessment of the efforts to remediate the Y2K problem in Ohio's school districts, cities and counties; (2) to identify issues that could affect…

Extended Aperture Photometry of K2 RR Lyrae stars

Directory of Open Access Journals (Sweden)

Plachy Emese

2017-01-01

Full Text Available We present the method of the Extended Aperture Photometry (EAP that we applied on K2 RR Lyrae stars. Our aim is to minimize the instrumental variations of attitude control maneuvers by using apertures that cover the positional changes in the field of view thus contain the stars during the whole observation. We present example light curves that we compared to the light curves from the K2 Systematics Correction (K2SC pipeline applied on the automated Single Aperture Photometry (SAP and on the Pre-search Data Conditioning Simple Aperture Photometry (PDCSAP data.

Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms

Directory of Open Access Journals (Sweden)

Stefan Bittner

2015-07-01

Full Text Available Lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. Expression levels of K2P5.1 (TASK2; KCNK5 channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive T lymphocytes in patients with multiple sclerosis and rheumatoid arthritis. In humans, K2P5.1 channels are upregulated upon T cell stimulation and influence T cell effector functions. However, a further clinical translation of targeting K2P5.1 is currently hampered by a lack of highly selective inhibitors, making it necessary to evaluate the impact of KCNK5 in established preclinical animal disease models. We here demonstrate that K2P5.1 knockout (K2P5.1−/− mice display no significant alterations concerning T cell cytokine production, proliferation rates, surface marker molecules or signaling pathways. In an experimental model of autoimmune neuroinflammation, K2P5.1−/− mice show a comparable disease course to wild-type animals and no major changes in the peripheral immune system or CNS compartment. A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1. As an alternative model mimicking autoimmune neuroinflammation, experimental autoimmune encephalomyelitis in the common marmoset has been proposed, especially for testing the efficacy of new potential drugs. Initial experiments show that K2P5.1 is functionally expressed on marmoset T lymphocytes, opening up the possibility for assessing future K2P5.1-targeting drugs.

Ozone production efficiency of a ship-plume: ITCT 2K2 case study.

Science.gov (United States)

Kim, Hyun S; Kim, Yong H; Han, Kyung M; Kim, Jhoon; Song, Chul H

2016-01-01

Ozone production efficiency (OPE) of ship plume was first evaluated in this study, based on ship-plume photochemical/dynamic model simulations and the ship-plume composition data measured during the ITCT 2K2 (Intercontinental Transport and Chemical Transformation 2002) aircraft campaign. The averaged instantaneous OPEs (OPE(i)‾) estimated via the ship-plume photochemical/dynamic modeling for the ITCT 2K2 ship-plume ranged between 4.61 and 18.92, showing that the values vary with the extent of chemical evolution (or chemical stage) of the ship plume and the stability classes of the marine boundary layer (MBL). Together with OPE(i)‾, the equivalent OPEs (OPE(e)‾) for the entire ITCT 2K2 ship-plume were also estimated. The OPE(e)‾ values varied between 9.73 (for the stable MBL) and 12.73 (for the moderately stable MBL), which agreed well with the OPE(e)‾ of 12.85 estimated based on the ITCT 2K2 ship-plume observations. It was also found that both the model-simulated and observation-based OPE(e)‾ inside the ship-plume were 0.29-0.38 times smaller than the OPE(e)‾ calculated/measured outside the ITCT 2K2 ship-plume. Such low OPEs insides the ship plume were due to the high levels of NO and non-liner ship-plume photochemistry. Possible implications of this ship-plume OPE study in the global chemistry-transport modeling are also discussed. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Altered expression of two-pore domain potassium (K2P channels in cancer.

Directory of Open Access Journals (Sweden)

Sarah Williams

Full Text Available Potassium channels have become a focus in cancer biology as they play roles in cell behaviours associated with cancer progression, including proliferation, migration and apoptosis. Two-pore domain (K2P potassium channels are background channels which enable the leak of potassium ions from cells. As these channels are open at rest they have a profound effect on cellular membrane potential and subsequently the electrical activity and behaviour of cells in which they are expressed. The K2P family of channels has 15 mammalian members and already 4 members of this family (K2P2.1, K2P3.1, K2P9.1, K2P5.1 have been implicated in cancer. Here we examine the expression of all 15 members of the K2P family of channels in a range of cancer types. This was achieved using the online cancer microarray database, Oncomine (www.oncomine.org. Each gene was examined across 20 cancer types, comparing mRNA expression in cancer to normal tissue. This analysis revealed all but 3 K2P family members (K2P4.1, K2P16.1, K2P18.1 show altered expression in cancer. Overexpression of K2P channels was observed in a range of cancers including breast, leukaemia and lung while more cancers (brain, colorectal, gastrointestinal, kidney, lung, melanoma, oesophageal showed underexpression of one or more channels. K2P1.1, K2P3.1, K2P12.1, were overexpressed in a range of cancers. While K2P1.1, K2P3.1, K2P5.1, K2P6.1, K2P7.1 and K2P10.1 showed significant underexpression across the cancer types examined. This analysis supports the view that specific K2P channels may play a role in cancer biology. Their altered expression together with their ability to impact the function of other ion channels and their sensitivity to environmental stimuli (pO2, pH, glucose, stretch makes understanding the role these channels play in cancer of key importance.

Study of K-p→0-1/2+ and K-p→0-3/2+ reactions

International Nuclear Information System (INIS)

Chaurand, B.M.G.

1976-01-01

With 1.3x10 6 photos taken with the CERN two meters hydrogen bubble chamber, interactions of the type K - p→0 - 1/2 + (3/2 + ) at 14.3GeV/c were studied. Experimental data are given as well as the amplitudes which describe these reactions, and show how they are connected with the measurable quantities; these are determined in each of the reactions whenever it is possible (sigma sub(T), dsigma/dt, polarization of Λ and Σ + , density matrix element of Σ + (1385)). The results are compared with those obtained at other energies and with some predictions of SU 3 . Finally, it is explained how the results have contributed to the analysis of the amplitudes of the reactions 0 - 1/2 + →0 - 1/2 + (3/2 + ) [fr

226Ra, 232Th and 40K analysis in sand samples from some beaches of Great Vitoria, Espirito Santo, Brazil: preliminary results

International Nuclear Information System (INIS)

Aquino, Reginaldo R.; Pecequilo, Brigitte R.S.

2009-01-01

The natural radioactivity in superficial beach sand samples of 7 beaches of Great Vitoria, metropolitan region of the State of Espirito Santo, southeast Brazil, was determined from the 226 Ra, 232 Th and 4 0 K contents. The assessed beaches were Manguinhos, Camburi, Praia do Canto, Curva da Jurema, Itapua, Setibao and Areia Preta. Three samples of each beach were sealed in standard 100 mL polyethylene flasks and stored in order to obtain secular equilibrium in the 238 U and 232 Th series. All samples were measured by high resolution gamma spectrometry and the spectra were analyzed with the WinnerGamma software. The 232 Th concentration was determined from the average concentrations of 228 Ac, 212 Pb and 212 Bi and the 226 Ra concentration was determined from the average concentrations of 214 Pb and 214 Bi. Preliminary results show concentrations varying from 9 Bq.kg -1 to 6035 Bq.kg -1 for 232 Th, from 4 Bq.kg -1 to 575 Bq.kg -1 for 226 Ra and from 13 Bq.kg -1 to 142 Bq.kg -1 for 40 K. Areia Preta beach shows the highest values for 232 Th, while the highest value for 226 Ra was observed for Camburi beach. High values of 40 K were observed for Curva da Jurema beach. (author)

The updated NAA nuclear data library derived from the Y2K k0-database

International Nuclear Information System (INIS)

Corte, F. De

2003-01-01

Values of 2200 m x s -1 cross sections, together with the associated nuclear data, are tabulated for 128 (n,γ) reactions of interest in NAA. The values are derived from the Y2K database of experimentally measured k 0 -factors. (author)

Penetration of the renewable sources of energy in Mexico: group of approach to determine the exogenous parameters of the LEAP simulation model (Annexe 10 in 'A vision of year 2030 on the use of the renewable energies in Mexico'); Penetracion de las fuentes renovables de energia en Mexico: grupo de enfoque para determinar los parametros exogenos del modelo de simulacion LEAP (Anexo 10 en 'Una vision al 2030 de la utilizacion de las energias renovables en Mexico')

Energy Technology Data Exchange (ETDEWEB)

Pernudi, Montserrat; Alonso C, Antonio [Analitica Consultores S.A. de C.V., Mexico D.F. (Mexico)

2005-08-15

The LEAP simulation model requires the values of some exogenous variables: At international level, the population increase, the economic growth and the international oil prices; at domestic level, the population increase, the economic growth, the energy intensity, the elasticity of demand of energy-price, and the elasticity of energy demand-gross national product. The use of the LEAP model for the estimation of the penetration of the renewable energies in Mexico comprises of the requirements established in the study. To estimate the future long term values of variables as the exogenous ones required by this model by means of expert opinion can be, given the nature of same, equally or more complicated and speculative than to directly consider the future rates of penetration of the renewable energies. In order to reflect on the future values of these variables a group of approach with experts was integrated. [Spanish] El modelo de simulacion LEAP requiere los valores de algunas variables exogenas: A nivel internacional, el crecimiento demografico, el crecimiento economico y los precios internacionales del petroleo; a nivel nacional, el crecimiento demografico, el crecimiento economico, la intensidad energetica, la elasticidad de demanda de energia-precio, y la elasticidad de demanda de energia-producto interno bruto. El uso del modelo LEAP para la estimacion de la penetracion de las energias renovables en Mexico forma parte de los requerimientos establecidos en el estudio. Estimar los futuros valores a largo plazo de variables como las exogenas requeridas por dicho modelo mediante opinion experta puede resultar, dada la naturaleza de las mismas, tan o mas complicado y especulativo que estimar las futuras tasas de penetracion de las energias renovables directamente. Para reflexionar sobre los futuros valores de dichas variables se integro un grupo de enfoque con expertos.

Development of 66 kV/6.9 kV 2 MV A prototype HTS power transformer

International Nuclear Information System (INIS)

Bohno, T.; Tomioka, A.; Imaizumi, M.; Sanuki, Y.; Yamamoto, T.; Yasukawa, Y.; Ono, H.; Yagi, Y.; Iwadate, K.

2005-01-01

We have developed the technology of the producing a HTS magnet for the power transformer. Three subjects have been mainly studied, high voltage technologies, large current and low AC loss technologies and sub-cooling system technologies to establish the technology of 66 kV/6.9 kV 10 MV A class HTS power transformer. In order to verify the validity of elemental technologies, such as high voltage technologies, large current and low AC loss technologies and sub-cooling system technologies, single-phase 2 MV A class 66 kV/6.9 kV prototype HTS transformer was manufactured and tested. In the load loss (AC loss) measurement, it was obtained that the measured value of 633 W was almost corresponding to the calculated value of 576 W at the rated operation of 2 MV A. Moreover, the breakdown was not found all voltage withstand test. These test results indicate that elemental technologies were established for the development of 66 kV/6.9 kV 10 MV A class HTS power transformer

The Leap of a Provincial SME into the Global Market Using E-commerce: The Success of Adequate Planning

Science.gov (United States)

Sainz de Abajo, Beatriz; García Salcines, Enrique; Burón Fernández, F. Javier; López Coronado, Miguel; de Castro Lozano, Carlos

The leap into the global market is not easy when it involves a provincial family business. This article demonstrates how adequate planning is fundamental in a small and medium-sized enterprise (SME) with the tight budget they have available to them, in order to be able to differentiate themselves in a highly competitive market, taking into accounts the benefits and risks involved. The Information Technology (IT) tools put in place will give the necessary support and allow for the possibility of increasing and improving the infrastructure as the company requires. An adequate strategy for the future to increases sales would be e-marketing techniques as well as the current promotions which contribute to diffusing the brand.

Transposition of the great arteries - a phenotype associated with 16p11.2 duplications?

Science.gov (United States)

Karunanithi, Zarmiga; Vestergaard, Else Marie; Lauridsen, Mette H

2017-12-26

Genetic analyses of patients with transposition of the great arteries have identified rare copy number variations, suggesting that they may be significant to the aetiology of the disease. This paper reports the identification of a 16p11.2 microduplication, a variation that has yet to be reported in association with transposition of the great arteries. The 16p11.2 microduplication is associated with autism spectrum disorder and developmental delay, but with highly variable phenotypic effects. Autism and attention deficit disorders are observed more frequently in children with congenital heart disease than in the general population. Neonatal surgery is proposed as a risk factor, but as yet unidentified genetic abnormalities should also be taken into account. Thus, congenital heart abnormalities may constitute a part of the phenotypic spectrum associated with duplications at 16p11.2. We suggest chromosomal microarray be considered part of the diagnostic work-up in patients with transposition of the great arteries.

Low Amount of Salinomycin Greatly Increases Akt Activation, but Reduces Activated p70S6K Levels

Directory of Open Access Journals (Sweden)

Sungpil Yoon

2013-08-01

Full Text Available The present study identified a novel salinomycin (Sal-sensitization mechanism in cancer cells. We analyzed the signal proteins Akt, Jnk, p38, Jak, and Erk1/2 in cancer cell lines that had arrested growth following low amounts of Sal treatment. We also tested the signal molecules PI3K, PDK1, GSK3β, p70S6K, mTOR, and PTEN to analyze the PI3K/Akt/mTOR pathway. The results showed that Sal sensitization positively correlates with large reductions in p70S6K activation. Interestingly, Akt was the only signal protein to be significantly activated by Sal treatment. The Akt activation appeared to require the PI3K pathway as its activation was abolished by the PI3K inhibitors LY294002 and wortmannin. The Akt activation by Sal was conserved in the other cell lines analyzed, which originated from other organs. Both Akt activation and C-PARP production were proportionally increased with increased doses of Sal. In addition, the increased levels of pAkt were not reduced over the time course of the experiment. Co-treatment with Akt inhibitors sensitized the Sal-treated cancer cells. The results thereby suggest that Akt activation is increased in cells that survive Sal treatment and resist the cytotoxic effect of Sal. Taken together; these results indicate that Akt activation may promote the resistance of cancer cells to Sal.

Phase transitions in K-doped MoO{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Alves, L. M. S., E-mail: leandro-fisico@hotmail.com; Lima, B. S. de; Santos, C. A. M. dos [Departamento de Engenharia de Materiais, Escola de Engenharia de Lorena-USP, Lorena, São Paulo 12602-810 (Brazil); Rebello, A.; Masunaga, S. H.; Neumeier, J. J. [Department of Physics, Montana State University, P.O. Box 173840, Bozeman, Montana 59717-3840 (United States); Leão, J. B. [NIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Dr. MS 6102, Gaithersburg, Maryland 20899-6102 (United States)

2014-05-28

K{sub 0.05}MoO{sub 2} has been studied by x-ray and neutron diffractometry, electrical resistivity, magnetization, heat capacity, and thermal expansion measurements. The compound displays two phase transitions, a first-order phase transition near room temperature and a second-order transition near 54 K. Below the transition at 54 K, a weak magnetic anomaly is observed and the electrical resistivity is well described by a power-law temperature dependence with exponent near 0.5. The phase transitions in the K-doped MoO{sub 2} compound have been discussed for the first time using neutron diffraction, high resolution thermal expansion, and heat capacity measurements as a function of temperature.

A compilation of K+p --> K0 DELTA++ cross sections below 2 GeV/c

CERN Document Server

Giacomelli, G; Piccinini, M; Rimondi, F; Serra-Lugaresi, P

1976-01-01

Data published up to June 1976 on the quasi-two-body reaction K+p --> K0 DELTA++, with DELTA++ -->ppi+, are compiled for laboratory momenta from 0.7 to 2 GeV/c. They include integrated cross-sections, differencial cross-sections, average and differential density matrix elements, as well as coefficients of the Legendre polynomial expensions of the production differential distributions. The data are presented in the form og graphs and computer-produced tables. The method of computation is the same as in a previous report (CERN-HERA-75-1) on K+N cross-sections below2 GeV/c, to which the reader is referred for details on cards formats, notations, etc.

Thermal synthesis of oxide molecular sieve and Mn (K-OMS-2) from K-birnessite obtained from Sol-gel method

International Nuclear Information System (INIS)

Rezende, D.S.; Figueira, B.A.M.; Moraes, M.C. de; Silva, L.N. da; Mercury, J.M.R.; Figueiredo, G.P. de

2016-01-01

This study presents the thermal synthesis of molecular sieve with K-OMS2 structure from K-birnessite tunneling process, one Mn oxide with structure in layer. According X-Ray diffraction data it was possible to monitoring the conversion of the layered structure around 550 deg C for (K-OMS-2) tunnel with tetragonal system and I2/m space group. The FTIR main spectrum bands of K-OMS-2 was observed in 700, 525 e 470 cm-1 region and are related to elongation Mn 3+ -O e Mn 4+ -O in the tunnel structure. The product morphology identified by Scanning Electron Microscopy it was verified as pseudo tetragonal, reflecting externally the crystallographic system of cryptomelane structure. The results reveal one simple route for the Mn oxide molecular sieve with K-OMS-2 structure

Browse Title Index

African Journals Online (AJOL)

Vol 21, No 1 (2007), “I Shall Take The Leap To The Great Beyond…”: Johannes Fagan's Studies And Suicide In London (1916-1920), Abstract. H van der Mescht. Vol 22, No 2 (2008), “O, Boereplaas, geboortegrond!” Afrikaner nostalgia and the romanticisation of the platteland in post-1994 South Africa, Abstract. D van Zyl.

Experimental (155 K) and predicted (151 K) Curie temperature (Tc) of K2ZnBr4: structural confirmation of ferroelectric state below Tc

International Nuclear Information System (INIS)

Abrahams, S.C.

1994-01-01

The temperature T c at which K 2 ZnBr 4 is predicted to transform from the paraelectric to the ferroelectric phase is 151 (19) K, based on the crystal structure determinations at 291 and 144 K by Fabry, Breczewski, Zuniga and Arnaiz and the Abrahams-Kurtz-Jamieson relationship. A dielectric and heat-capacity anomaly in this material at 155 K has been reported elsewhere. The locations reported for the ZnBr 2- 4 and K + ions fulfill the requirements of mirror plane symmetry above T c ; ionic displacements along the polar direction that approach but do not exceed 0.1 A and that violate the mirror symmetry on cooling through T c form the basis of the prediction and satisfy the structural criteria for ferroelectricity in the phase below the transition. (orig.)

The great tsunami of 26 December 2004: A description based on tide gauge data from Indian subcontinent and surrounding areas

Digital Repository Service at National Institute of Oceanography (India)

Nagarajan, B.; Suresh, I; Sundar, D.; Sharma, R; Lal, A.K.; Neetu, S.; Shenoi, S.S.C.; Shetye, S.R; Shankar, D.

-1 Earth Planets Space, 58, 211?215, 2006 The Great Tsunami of 26 December 2004: A description based on tide-gauge data from the Indian subcontinent and surrounding areas B. Nagarajan1, I. Suresh2, D. Sundar2, R. Sharma1,A.K.Lal1, S. Neetu2, S. S. C. Shenoi..., I. Suresh, D. Sundar, R. Sharma, A. K. Lal, S. Neetu, S. S. C. Shenoi, S. R. Shetye, and D. Shankar (e-mail: shankar@nio.org) ...

In-air and underwater hearing in the great cormorant (Phalacrocorax carbo sinensis)

DEFF Research Database (Denmark)

Johansen, Sasia; Larsen, Ole Næsbye; Christensen-Dalsgaard, Jakob

2016-01-01

Hearing thresholds of a great cormorant (Phalacrocorax carbo) were measured in air and under water using psychophysics. The lowest thresholds were at 2 kHz (45 dB re 20 μPa root-mean-square [rms] in air and 79 dB re 1 μPa rms in water). Auditory brainstem response measurements on one anesthetized...

Comparative effects of vitamin K2 and vitamin E on experimental arteriosclerosis.

Science.gov (United States)

Seyama, Y; Hayashi, M; Takegami, H; Usami, E

1999-01-01

The comparative effects of vitamin K2 and vitamin E on aortic calcium (Ca) and inorganic phosphorus (P) levels in the aorta and the elastin fraction (fr.) were investigated in male rats after experimental arteriosclerosis was induced by vitamin D2 with atherogenic diet. Both vitamin K2 (100 mg/kg b.w.) and vitamin E (40 mg/kg b.w.) inhibited the increase of Ca and P in the aorta and the elastin fr. from the arteriosclerotic rats. Vitamin K2 (50 mg/kg b.w.) also suppressed the deposition of Ca and P in the aorta, but there was no change due to vitamin K3 or geranylgeraniol (side chain of vitamin K2) administration. Both vitamin K2 and vitamin E showed lipid radical scavenging activity in the in vitro experiment. However, neither vitamin K3 nor geranylgeraniol exhibited anti-arteriosclerotic or radical scavenging activity under the above experimental conditions. It is suggested that vitamin K2 and vitamin E promoted an antiarteriosclerotic effect by radical scavenging activity. These actions of vitamin K2 are required in the structure of 2-methylnaphtoquinone and its side chain (geranylgeraniol).

Screening the budding yeast genome reveals unique factors affecting K2 toxin susceptibility.

Science.gov (United States)

Servienė, Elena; Lukša, Juliana; Orentaitė, Irma; Lafontaine, Denis L J; Urbonavičius, Jaunius

2012-01-01

Understanding how biotoxins kill cells is of prime importance in biomedicine and the food industry. The budding yeast (S. cerevisiae) killers serve as a convenient model to study the activity of biotoxins consistently supplying with significant insights into the basic mechanisms of virus-host cell interactions and toxin entry into eukaryotic target cells. K1 and K2 toxins are active at the cell wall, leading to the disruption of the plasma membrane and subsequent cell death by ion leakage. K28 toxin is active in the cell nucleus, blocking DNA synthesis and cell cycle progression, thereby triggering apoptosis. Genome-wide screens in the budding yeast S. cerevisiae identified several hundred effectors of K1 and K28 toxins. Surprisingly, no such screen had been performed for K2 toxin, the most frequent killer toxin among industrial budding yeasts. We conducted several concurrent genome-wide screens in S. cerevisiae and identified 332 novel K2 toxin effectors. The effectors involved in K2 resistance and hypersensitivity largely map in distinct cellular pathways, including cell wall and plasma membrane structure/biogenesis and mitochondrial function for K2 resistance, and cell wall stress signaling and ion/pH homeostasis for K2 hypersensitivity. 70% of K2 effectors are different from those involved in K1 or K28 susceptibility. Our work demonstrates that despite the fact that K1 and K2 toxins share some aspects of their killing strategies, they largely rely on different sets of effectors. Since the vast majority of the host factors identified here is exclusively active towards K2, we conclude that cells have acquired a specific K2 toxin effectors set. Our work thus indicates that K1 and K2 have elaborated different biological pathways and provides a first step towards the detailed characterization of K2 mode of action.

The rate coefficient for the reaction NO2 + NO3 yielding NO + NO2 + O2 from 273 to 313 K

Science.gov (United States)

Cantrell, Chris A.; Shetter, Richard E.; Mcdaniel, Anthony H.; Calvert, Jack G.

1990-01-01

The ratio of rate constants for the reaction NO3 + NO yielding 2 NO2 (k3) and the reaction NO2 + NO3 yielding NO + NO2 + O2 (k4) were determined by measuring of NO and NO2 concentrations of NO and NO2 in an N2O5/NO2/N2 mixture over the temperature range 273-313 K. The measured ratio was found to be expressed by the equation k3/k4 = 387 exp(-1375/T). The results are consistent with those of Hammer et al. (1986).

K2 killer toxin-induced physiological changes in the yeast Saccharomyces cerevisiae.

Science.gov (United States)

Orentaite, Irma; Poranen, Minna M; Oksanen, Hanna M; Daugelavicius, Rimantas; Bamford, Dennis H

2016-03-01

Saccharomyces cerevisiae cells produce killer toxins, such as K1, K2 and K28, that can modulate the growth of other yeasts giving advantage for the killer strains. Here we focused on the physiological changes induced by K2 toxin on a non-toxin-producing yeast strain as well as K1, K2 and K28 killer strains. Potentiometric measurements were adjusted to observe that K2 toxin immediately acts on the sensitive cells leading to membrane permeability. This correlated with reduced respiration activity, lowered intracellular ATP content and decrease in cell viability. However, we did not detect any significant ATP leakage from the cells treated by killer toxin K2. Strains producing heterologous toxins K1 and K28 were less sensitive to K2 than the non-toxin producing one suggesting partial cross-protection between the different killer systems. This phenomenon may be connected to the observed differences in respiratory activities of the killer strains and the non-toxin-producing strain at low pH. This might also have practical consequences in wine industry; both as beneficial ones in controlling contaminating yeasts and non-beneficial ones causing sluggish fermentation. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Thio-, selenido-, and telluridogermanates(III): K/sub 6/Ge/sub 2/S/sub 6/, K/sub 6/Ge/sub 2/Se/sub 6/, and Na/sub 6/Ge/sub 2/Te/sub 6/

Energy Technology Data Exchange (ETDEWEB)

Eisenmann, B; Kieselbach, E; Schaefer, H; Schrod, H [Technische Hochschule Darmstadt (Germany, F.R.). Fachbereich Anorganische Chemie und Kernchemie

1984-09-01

The new compounds K/sub 6/Ge/sub 2/S/sub 6/ and K/sub 6/Ge/sub 2/Se/sub 6/ crystallize in the monoclinic system, space group C2/m (No 12). The compounds are isotypic and form the K/sub 6/Si/sub 2/Te/sub 6/ structure. Na/sub 6/Ge/sub 2/Te/sub 6/ crystallizes in the K/sub 6/Sn/sub 2/Te/sub 6/ structure, monoclinic, space group P2/sub 1//c (No 14). The lattice constants are given.

Thermal properties of KUO3(s) and K2U2O7 - by high temperature Calvet calorimeter

International Nuclear Information System (INIS)

Jayanthi, K.; Iyer, V.S.; Venugopal, V.

1998-01-01

The thermal properties of KUO 3 (s) and K 2 U 2 O 7 (s) were determined using a high temperature Calvet calorimeter by drop method. The enthalpy increments, (H T o - H 298.15 0 ), in kJ/mol for KUO 3 (s) and K 2 U 2 O 7 (s) can be represented by, H T o - H 298.15 0 KUO 3 (s) kJ/mol ± 0.7 = -39.15 + 0.129T + 0.1005x10 -4 T 2 (369-714K) and H T o -H 298.15 0 K 2 U 2 O 7 (s) kJ/mol ± 0.7 = -52.99 + 0.1361T + 0.146x10 -3 T 2 (391 - 683K). (author)

Surface reactions during low-k etching using H2/N2 plasma

International Nuclear Information System (INIS)

Fukasawa, Masanaga; Tatsumi, Tetsuya; Oshima, Keiji; Nagahata, Kazunori; Uchida, Saburo; Takashima, Seigo; Hori, Masaru; Kamide, Yukihiro

2008-01-01

We investigated the relationship between the hard mask faceting that occurs during organic low-k etching and the ion energy distribution function of a capacitively coupled plasma reactor. We minimized the hard mask faceting by precisely controlling the ion energy. This precise control was obtained by selecting the optimum bottom frequency and bias power. We measured the amount of damage done to a SiOCH film exposed to H 2 /N 2 plasma in order to find the H 2 /N 2 ratio at which the plasma caused the least damage. The amount of moisture uptake by the damaged SiOCH film is the dominant factor controlling the dielectric constant increase (Δk). To suppress Δk, the incident ion species and ion energies have to be precisely controlled. This reduces the number of adsorption sites in the bulk SiOCH and maintains the hydrophobic surface that suppresses water permeation during air exposure

PROBING TRAPPIST-1-LIKE SYSTEMS WITH K2

Energy Technology Data Exchange (ETDEWEB)

Demory, Brice-Olivier; Queloz, Didier; Gillen, Ed [Astrophysics Group, Cavendish Laboratory, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Alibert, Yann [Physikalisches Institut and Center for Space and Habitability, Universität Bern, 3012 Bern (Switzerland); Gillon, Michael, E-mail: bod21@cam.ac.uk [Institut d’Astrophysique et de Geophysique, Universite de Liege, Allee du 6 Aout 17, Bat. B5C, B-4000 Liege (Belgium)

2016-07-10

The search for small planets orbiting late M dwarfs holds the promise of detecting Earth-size planets for which their atmospheres could be characterized within the next decade. The recent discovery of TRAPPIST-1 entertains hope that these systems are common around hosts located at the bottom of the main sequence. In this Letter, we investigate the ability of the repurposed Kepler mission ( K2 ) to probe planetary systems similar to TRAPPIST-1. We perform a consistent data analysis of 189 spectroscopically confirmed M5.5 to M9 late M dwarfs from Campaigns 1–6 to search for planet candidates and inject transit signals with properties matching TRAPPIST-1b and c. We find no transiting planet candidates across our K2 sample. Our injection tests show that K2 is able to recover both TRAPPIST-1 planets for 10% of the sample only, mainly because of the inefficient throughput at red wavelengths resulting in Poisson-limited performance for these targets. Increasing injected planetary radii to match GJ 1214b’s size yields a recovery rate of 70%. The strength of K2 is its ability to probe a large number of cool hosts across the different campaigns, out of which the recovery rate of 10% may turn into bona fide detections of TRAPPIST-1-like systems within the next two years.