DISPLAY3D. A Graphics Preprocessor for CHIEF

Science.gov (United States)

1990-12-27

graphics devices, the user may write a graphics program th.,.t can read DISPLAY3D output files, or use one of the commercial plotting packages...COMMON/NBPRTC/IRHSPT, NARSPT, NPTBLK FRQPT COMMON/NBPRTS/SYMTPT CHARACTER*3 SYMTPT DIMENSION CC(10), TRNS(3), IELTS (8,300) real xl(1000) ,yl(leee...C Prompt the user for filename. C--- ------------------------------------------------------- WRITE (6,1) ’Enter filename used in CID or

Computer graphic display of cardiac CT scans

International Nuclear Information System (INIS)

Palmer, R.; Carlsson, E.

1982-01-01

In order to improve spatial conception and quantitative assessment of the cardiac structures based on cardiac computed tomography, methods for computer graphic display were developed. Excised hearts and living dogs with myocardial infarctions were subjected to CT scanning. The data on the scanner tapes were processed to provide isodensity plots, linear section plots, time-weighted integrated isodensity plots as well as topographical density displays and three-dimensional spatial reconstructions of single and multi-layer scans. (orig.)

A CAMAC display module for fast bit-mapped graphics

International Nuclear Information System (INIS)

Abdel-Aal, R.E.

1992-01-01

In many data acquisition and analysis facilities for nuclear physics research, utilities for the display of two-dimensional (2D) images and spectra on graphics terminals suffer from low speed, poor resolution, and limit accuracy. Developed of CAMAC bit-mapped graphics modules for this purpose has been discouraged in the past by the large device count needed and the long times required to load the image data from the host computer into the CAMAC hardware; particularly since many such facilities have been designed to support fast DMA block transfers only for data acquisition into the host. This paper describes the design and implementation of a prototype CAMAC graphics display module with a resolution of 256x256 pixels at eight colours for which all components can be easily accommodated in a single-width package. Employed is a hardware technique which reduces the number of programmed CAMAC data transfer operations needed for writing 2D images into the display memory by approximately an order of magnitude, with attendant improvements in the display speed and CPU time consumption. Hardware and software details are given together with sample results. Information on the performance of the module in a typical VAX/MBD data acquisition environment is presented, including data on the mutual effects of simultaneous data acquisition traffic. Suggestions are made for further improvements in performance. (orig.)

Role of computer graphics in space telerobotics - Preview and predictive displays

Science.gov (United States)

Bejczy, Antal K.; Venema, Steven; Kim, Won S.

1991-01-01

The application of computer graphics in space telerobotics research and development work is briefly reviewed and illustrated by specific examples implemented in real time operation. The applications are discussed under the following four major categories: preview displays, predictive displays, sensor data displays, and control system status displays.

Development of a graphical user interface and graphics display for the WIND system

International Nuclear Information System (INIS)

O'Steen, B.L.; Fast, J.D.; Suire, B.S.

1992-01-01

An advanced graphical user interface (GUI) and improved graphics for transport calculations have been developed for the Weather Information and Display System (WINDS). Two WINDS transport codes, Area Evac and 2DPUF, have been ported from their original VAX/VMS environment to a UNIX operating system and reconfigured to take advantage of the new graphics capability. A developmental prototype of this software is now available on a UNIX based IBM 340 workstation in the Dose Assessment Center (DAC). Automatic transfer of meteorological data from the WINDS VAX computers to the IBM workstation in the DAC has been implemented. This includes both regional National Weather Service (NWS) data and SRS tower data. The above developments fulfill a FY 1993 DOE milestone

A computer graphics display technique for the examination of aircraft design data

Science.gov (United States)

Talcott, N. A., Jr.

1981-01-01

An interactive computer graphics technique has been developed for quickly sorting and interpreting large amounts of aerodynamic data. It utilizes a graphic representation rather than numbers. The geometry package represents the vehicle as a set of panels. These panels are ordered in groups of ascending values (e.g., equilibrium temperatures). The groups are then displayed successively on a CRT building up to the complete vehicle. A zoom feature allows for displaying only the panels with values between certain limits. The addition of color allows a one-time display thus eliminating the need for a display build up.

Epitope selection from an uncensored peptide library displayed on avian leukosis virus

International Nuclear Information System (INIS)

Khare, Pranay D.; Rosales, Ana G.; Bailey, Kent R.; Russell, Stephen J.; Federspiel, Mark J.

2003-01-01

Phage display libraries have provided an extraordinarily versatile technology to facilitate the isolation of peptides, growth factors, single chain antibodies, and enzymes with desired binding specificities or enzymatic activities. The overall diversity of peptides in phage display libraries can be significantly limited by Escherichia coli protein folding and processing machinery, which result in sequence censorship. To achieve an optimal diversity of displayed eukaryotic peptides, the library should be produced in the endoplasmic reticulum of eukaryotic cells using a eukaryotic display platform. In the accompanying article, we presented experiments that demonstrate that polypeptides of various sizes could be efficiently displayed on the envelope glycoproteins of a eukaryotic virus, avian leukosis virus (ALV), and the displayed polypeptides could efficiently attach to cognate receptors without interfering with viral attachment and entry into susceptible cells. In this study, methods were developed to construct a model library of randomized eight amino acid peptides using the ALV eukaryotic display platform and screen the library for specific epitopes using immobilized antibodies. A virus library with approximately 2 x 10 6 different members was generated from a plasmid library of approximately 5 x 10 6 diversity. The sequences of the randomized 24 nucleotide/eight amino acid regions of representatives of the plasmid and virus libraries were analyzed. No significant sequence censorship was observed in producing the virus display library from the plasmid library. Different populations of peptide epitopes were selected from the virus library when different monoclonal antibodies were used as the target. The results of these two studies clearly demonstrate the potential of ALV as a eukaryotic platform for the display and selection of eukaryotic polypeptides libraries

SPIDERGL: A GRAPHICS LIBRARY FOR 3D WEB APPLICATIONS

Directory of Open Access Journals (Sweden)

M. Di Benedetto

2012-09-01

Full Text Available The recent introduction of the WebGL API for leveraging the power of 3D graphics accelerators within Web browsers opens the possibility to develop advanced graphics applications without the need for an ad-hoc plug-in. There are several contexts in which this new technology can be exploited to enhance user experience and data fruition, like e-commerce applications, games and, in particular, Cultural Heritage. In fact, it is now possible to use the Web platform to present a virtual reconstruction hypothesis of ancient pasts, to show detailed 3D models of artefacts of interests to a wide public, and to create virtual museums. We introduce SpiderGL, a JavaScript library for developing 3D graphics Web applications. SpiderGL provides data structures and algorithms to ease the use of WebGL, to define and manipulate shapes, to import 3D models in various formats, and to handle asynchronous data loading. We show the potential of this novel library with a number of demo applications and give details about its future uses in the context of Cultural Heritage applications.

A low-cost system for graphical process monitoring with colour video symbol display units

International Nuclear Information System (INIS)

Grauer, H.; Jarsch, V.; Mueller, W.

1977-01-01

A system for computer controlled graphic process supervision, using color symbol video displays is described. It has the following characteristics: - compact unit: no external memory for image storage - problem oriented simple descriptive cut to the process program - no restriction of the graphical representation of process variables - computer and display independent, by implementation of colours and parameterized code creation for the display. (WB) [de

TEK11 graphics user's guide

International Nuclear Information System (INIS)

Stewart, C.R. Jr.; Joubert, W.D.; Overbey, D.R.; Stewart, K.A.

1978-10-01

The TEK11 graphics library was written for use on PDP-11 minicomputers running the RT-11 operating system to drive Tektronix 4010 graphics display terminals. Library subroutines are coded in FORTRAN and assembly language. The library includes routines to draw axes, either linear or semilog, to plot data in terms of logical values without first scaling to screen coordinates, to label graphs, and to plot in a maximum of four regions on the screen. Modes of plotting may be point plot with any character at the point, vector plot, or bar plot. Two features, automatic scaling and windowing, permit the researcher to use computer graphics without spending time first to learn about scaling or ''Tek points'' and preparing long parameter lists for subroutines. Regions on the screen are defined by specifying minima and maxima logical coordinates, i.e., 0 K or milliseconds, and a region number. After definition, a region may be activated for plotting by calling REGN with the region number as an argument

Working at a Ferranti-Argus graphics display linked to a CDC 6600

CERN Multimedia

CERN PhotoLab

1975-01-01

The photo shows a Ferranti-Argus graphics display linked to a CDC 6600 computer running one of the first interactive graphics packages for physics analysis. The people around are Jean-Claude Marin, Harry Renshall and Emilio Pagiola (right).

Real-time graphic display utility for nuclear safety applications

International Nuclear Information System (INIS)

Yang, S.; Huang, X.; Taylor, J.; Stevens, J.; Gerardis, T.; Hsu, A.; McCreary, T.

2006-01-01

With the increasing interests in the nuclear energy, new nuclear power plants will be constructed and licensed, and older generation ones will be upgraded for assuring continuing operation. The tendency of adopting the latest proven technology and the fact of older parts becoming obsolete have made the upgrades imperative. One of the areas for upgrades is the older CRT display being replaced by the latest graphics displays running under modern real time operating system (RTOS) with safety graded modern computer. HFC has developed a graphic display utility (GDU) under the QNX RTOS. A standard off-the-shelf software with a long history of performance in industrial applications, QNX RTOS used for safety applications has been examined via a commercial dedication process that is consistent with the regulatory guidelines. Through a commercial survey, a design life cycle and an operating history evaluation, and necessary tests dictated by the dedication plan, it is reasonably confirmed that the QNX RTOS was essentially equivalent to what would be expected in the nuclear industry. The developed GDU operates and communicates with the existing equipment through a dedicated serial channel of a flat panel controller (FPC) module. The FPC module drives a flat panel display (FPD) monitor. A touch screen mounted on the FPD serves as the normal operator interface with the FPC/FPD monitor system. The GDU can be used not only for replacing older CRTs but also in new applications. The replacement of the older CRT does not disturb the function of the existing equipment. It not only provides modern proven technology upgrade but also improves human ergonomics. The FPC, which can be used as a standalone controller running with the GDU, is an integrated hardware and software module. It operates as a single board computer within a control system, and applies primarily to the graphics display, targeting, keyboard and mouse. During normal system operation, the GDU has two sources of data

Phage display peptide libraries: deviations from randomness and correctives

Science.gov (United States)

Ryvkin, Arie; Ashkenazy, Haim; Weiss-Ottolenghi, Yael; Piller, Chen; Pupko, Tal; Gershoni, Jonathan M

2018-01-01

Abstract Peptide-expressing phage display libraries are widely used for the interrogation of antibodies. Affinity selected peptides are then analyzed to discover epitope mimetics, or are subjected to computational algorithms for epitope prediction. A critical assumption for these applications is the random representation of amino acids in the initial naïve peptide library. In a previous study, we implemented next generation sequencing to evaluate a naïve library and discovered severe deviations from randomness in UAG codon over-representation as well as in high G phosphoramidite abundance causing amino acid distribution biases. In this study, we demonstrate that the UAG over-representation can be attributed to the burden imposed on the phage upon the assembly of the recombinant Protein 8 subunits. This was corrected by constructing the libraries using supE44-containing bacteria which suppress the UAG driven abortive termination. We also demonstrate that the overabundance of G stems from variant synthesis-efficiency and can be corrected using compensating oligonucleotide-mixtures calibrated by mass spectroscopy. Construction of libraries implementing these correctives results in markedly improved libraries that display random distribution of amino acids, thus ensuring that enriched peptides obtained in biopanning represent a genuine selection event, a fundamental assumption for phage display applications. PMID:29420788

General-Purpose Software For Computer Graphics

Science.gov (United States)

Rogers, Joseph E.

1992-01-01

NASA Device Independent Graphics Library (NASADIG) is general-purpose computer-graphics package for computer-based engineering and management applications which gives opportunity to translate data into effective graphical displays for presentation. Features include two- and three-dimensional plotting, spline and polynomial interpolation, control of blanking of areas, multiple log and/or linear axes, control of legends and text, control of thicknesses of curves, and multiple text fonts. Included are subroutines for definition of areas and axes of plots; setup and display of text; blanking of areas; setup of style, interpolation, and plotting of lines; control of patterns and of shading of colors; control of legends, blocks of text, and characters; initialization of devices; and setting of mixed alphabets. Written in FORTRAN 77.

Graphical User Interfaces and Library Systems: End-User Reactions.

Science.gov (United States)

Zorn, Margaret; Marshall, Lucy

1995-01-01

Describes a study by Parke-Davis Pharmaceutical Research Library to determine user satisfaction with the graphical user interface-based (GUI) Dynix Marquis compared with the text-based Dynix Classic Online Public Access Catalog (OPAC). Results show that the GUI-based OPAC was preferred by endusers over the text-based OPAC. (eight references) (DGM)

Scientific Graphical Displays on the Macintosh

Energy Technology Data Exchange (ETDEWEB)

Grotch, S. [Lawrence Livermore National Lab., CA (United States)

1994-11-15

In many organizations scientists have ready access to more than one computer, often both a workstation (e.g., SUN, HP, SGI) as well as a Macintosh or other PC. The scientist commonly uses the work station for `number-crunching` and data analysis whereas the Macintosh is relegated to either word processing or serves as a `dumb terminal` to a larger main-frame computer. In an informal poll of my colleagues, very few of them used their Macintoshes for either statistical analysis or for graphical data display. I believe that this state of affairs is particularly unfortunate because over the last few years both the computational capability, and even more so, the software availability for the Macintosh have become quite formidable. In some instances, very powerful tools are now available on the Macintosh that may not exist (or be far too costly) on the so-called `high end` workstations. Many scientists are simply unaware of the wealth of extremely useful, `off-the-shelf` software that already exists on the Macintosh for scientific graphical and statistical analysis.

Management Matters. Display and Promotion Ideas for Library Media Centers

Science.gov (United States)

Pappas, Marjorie L.

2005-01-01

School library media centers should be warm and inviting places where the environment entices children to read and explore. Creative bulletin board and case displays along with other exhibits help to make the library media center an exciting place. Bulletin board displays that promote authors, books, and exciting ideas motivate children to find…

JAVA Stereo Display Toolkit

Science.gov (United States)

Edmonds, Karina

2008-01-01

This toolkit provides a common interface for displaying graphical user interface (GUI) components in stereo using either specialized stereo display hardware (e.g., liquid crystal shutter or polarized glasses) or anaglyph display (red/blue glasses) on standard workstation displays. An application using this toolkit will work without modification in either environment, allowing stereo software to reach a wider audience without sacrificing high-quality display on dedicated hardware. The toolkit is written in Java for use with the Swing GUI Toolkit and has cross-platform compatibility. It hooks into the graphics system, allowing any standard Swing component to be displayed in stereo. It uses the OpenGL graphics library to control the stereo hardware and to perform the rendering. It also supports anaglyph and special stereo hardware using the same API (application-program interface), and has the ability to simulate color stereo in anaglyph mode by combining the red band of the left image with the green/blue bands of the right image. This is a low-level toolkit that accomplishes simply the display of components (including the JadeDisplay image display component). It does not include higher-level functions such as disparity adjustment, 3D cursor, or overlays all of which can be built using this toolkit.

Graphic Data Display from Manufacturing on Web Pages

Directory of Open Access Journals (Sweden)

Martin VALAS

2009-06-01

Full Text Available Industrial data can by displayed in graphical form which is usually used by three types of users. The first, nonstop users, most frequent operational engineer, who checking actual displayed values and then intervene in operation. The second are occasional users who are interested in historical data e.g. for servicing reason. The last users’ types are tradesmen and managers. State comparison few days or months ago helps as decision-making support. Graph component with web application, which provides data as XML document, was designed for second users group. Graph component displays historical data. Students can fully understand all the problems go along with web application creation in ASP.NET, which provides data in XML document, as well as graph component creation in integrated development environment Flash, thanks in detail described solution using ActionScript.

Construction and Selection of Affilin® Phage Display Libraries.

Science.gov (United States)

Settele, Florian; Zwarg, Madlen; Fiedler, Sebastian; Koscheinz, Daniel; Bosse-Doenecke, Eva

2018-01-01

Affilin ® molecules represent a new class of so-called scaffold proteins. The concept of scaffold proteins is to use stable and versatile protein structures which can be endowed with de novo binding properties and specificities by introducing mutations in surface exposed amino acid residues. Complex variations and combinations are generated by genetic methods of randomization resulting in large cDNA libraries. The selection for candidates binding to a desired target can be executed by display methods, especially the very robust and flexible phage display. Here, we describe the construction of ubiquitin based Affilin ® phage display libraries and their use in biopanning experiments for the identification of novel protein ligands.

A Functional Programming Technique for Forms in Graphical User Interfaces

NARCIS (Netherlands)

Evers, S.; Kuper, Jan; Achten, P.M.; Grelck, G.; Huch, F.; Michaelson, G.; Trinder, Ph.W.

2005-01-01

This paper presents FunctionalForms, a new combinator library for constructing fully functioning forms in a concise and flexible way. A form is a part of a graphical user interface (GUI) restricted to displaying a value and allowing the user to modify it. The library is built on top of the

Network, system, and status software enhancements for the autonomously managed electrical power system breadboard. Volume 4: Graphical status display

Science.gov (United States)

Mckee, James W.

1990-01-01

This volume (4 of 4) contains the description, structured flow charts, prints of the graphical displays, and source code to generate the displays for the AMPS graphical status system. The function of these displays is to present to the manager of the AMPS system a graphical status display with the hot boxes that allow the manager to get more detailed status on selected portions of the AMPS system. The development of the graphical displays is divided into two processes; the creation of the screen images and storage of them in files on the computer, and the running of the status program which uses the screen images.

Interactive computer graphics displays for hierarchical data structures

International Nuclear Information System (INIS)

Cahn, D.F.; Murano, C.V.

1980-05-01

An interactive computer graphical display program was developed as an aid to user visualization and manipulation of hierarchically structured data systems such as thesauri. In the present configuration, a thesaurus term and its primary and secondary conceptual neighbors are presented to the user in tree graph form on a CRT; the user then designates, via light pen or keyboard, any of the neighbors as the next term of interest and receives a new display centered on this term. By successive specification of broader, narrower, and related terms, the user can course rapidly through the thesaurus space and refine his search file. At any stage, he deals with a term-centered, conceptually meaningful picture of a localized portion of the thesaurus, and is freed from the artificial difficulties of handling the traditional alphabetized thesaurus. Intentional limitation of the associative range of each display frame, and the use of color, case, and interconnecting vectors to encode relationships among terms, enhance interpretability of the display. Facile movement through the term space, provided by interactive computation, allows the display to remain simple, and is an essential element of the system. 3 figures

Human factors engineering in the design of colour-graphic displays

International Nuclear Information System (INIS)

Fenton, E.F.

1985-01-01

The operator interface for Ontario Hydro's Darlington Nuclear Generating Station will rely extensively on the use of coloured graphic display formats. These are used for the presentation of both control and monitoring information. The displays are organized in a hierarchical relationship and a simple interactive selection method using light pens has been implemented. The application of human factors engineering principles has been a major factor in all aspects of the design. This paper describes the system and the human factors engineering function

Graphic terminal based on storage tube display with microcomputer

International Nuclear Information System (INIS)

Leich, H.; Levchanovsky, F.; Nikulnikov, A.; Polyntsev, A.; Prikhodko, V.

1981-01-01

This paper describes a graphic terminal where a microcomputer realizes functions like the generation of picture elements (points, symbols, vectors), display control, processing of data received from keyboard and trackball, communication with a host computer and others. The terminal has been designed for operating in a local network as well as in autonomous control systems for data acquisition and processing in physical experiments [ru

Display of a Maize cDNA library on baculovirus infected insect cells

Directory of Open Access Journals (Sweden)

Jones Ian M

2008-08-01

Full Text Available Abstract Background Maize is a good model system for cereal crop genetics and development because of its rich genetic heritage and well-characterized morphology. The sequencing of its genome is well advanced, and new technologies for efficient proteomic analysis are needed. Baculovirus expression systems have been used for the last twenty years to express in insect cells a wide variety of eukaryotic proteins that require complex folding or extensive posttranslational modification. More recently, baculovirus display technologies based on the expression of foreign sequences on the surface of Autographa californica (AcMNPV have been developed. We investigated the potential of a display methodology for a cDNA library of maize young seedlings. Results We constructed a full-length cDNA library of young maize etiolated seedlings in the transfer vector pAcTMVSVG. The library contained a total of 2.5 × 105 independent clones. Expression of two known maize proteins, calreticulin and auxin binding protein (ABP1, was shown by western blot analysis of protein extracts from insect cells infected with the cDNA library. Display of the two proteins in infected insect cells was shown by selective biopanning using magnetic cell sorting and demonstrated proof of concept that the baculovirus maize cDNA display library could be used to identify and isolate proteins. Conclusion The maize cDNA library constructed in this study relies on the novel technology of baculovirus display and is unique in currently published cDNA libraries. Produced to demonstrate proof of principle, it opens the way for the development of a eukaryotic in vivo display tool which would be ideally suited for rapid screening of the maize proteome for binding partners, such as proteins involved in hormone regulation or defence.

Design, testing, and delivery of an interactive graphics display subsystem

Science.gov (United States)

Holmes, B.

1973-01-01

An interactive graphics display system was designed to be used in locating components on a printed circuit card and outputting data concerning their thermal values. The manner in which this was accomplished in terms of both hardware and software is described. An analysis of the accuracy of this approach is also included.

News from the Library: newspapers anyone? Try PressDisplay!

CERN Multimedia

CERN Library

2011-01-01

PressDisplay is an online portal where you can browse and read online articles from more than 1,900 newspapers from 95 countries, as soon as they are published. With Pressdisplay, the time when newspapers were nicely displayed on wooden rods in libraries has passed...   Le Monde, International Herald Tribune and many more titles are displayed in their original layout including text and images, and you can print and e-mail the articles you are interested in. You even have the possibility to create rss feeds, so that the news reaches you directly.   The CERN Library has now activated a trial version of PressDisplay valid till 31 December; it is open to everyone at CERN. This trial doesn't offer the possibility to create personalised alerts based on specific search criteria. In case you need such features - or if you have any comments or questions - please contact us.

Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries.

Science.gov (United States)

Wenderski, Todd A; Stratton, Christopher F; Bauer, Renato A; Kopp, Felix; Tan, Derek S

2015-01-01

Principal component analysis (PCA) is a useful tool in the design and planning of chemical libraries. PCA can be used to reveal differences in structural and physicochemical parameters between various classes of compounds by displaying them in a convenient graphical format. Herein, we demonstrate the use of PCA to gain insight into structural features that differentiate natural products, synthetic drugs, natural product-like libraries, and drug-like libraries, and show how the results can be used to guide library design.

Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening.

Directory of Open Access Journals (Sweden)

Hye-Ji Choi

Full Text Available Immunoglobulin Fc heterodimers, which are useful scaffolds for the generation of bispecific antibodies, have been mostly generated through structure-based rational design methods that introduce asymmetric mutations into the CH3 homodimeric interface to favor heterodimeric Fc formation. Here, we report an approach to generate heterodimeric Fc variants through directed evolution combined with yeast surface display. We developed a combinatorial heterodimeric Fc library display system by mating two haploid yeast cell lines, one haploid cell line displayed an Fc chain library (displayed FcCH3A with mutations in one CH3 domain (CH3A on the yeast cell surface, and the other cell line secreted an Fc chain library (secreted FcCH3B with mutations in the other CH3 domain (CH3B. In the mated cells, secreted FcCH3B is displayed on the cell surface through heterodimerization with the displayed FcCH3A, the detection of which enabled us to screen the library for heterodimeric Fc variants. We constructed combinatorial heterodimeric Fc libraries with simultaneous mutations in the homodimer-favoring electrostatic interaction pairs K370-E357/S364 or D399-K392/K409 at the CH3 domain interface. High-throughput screening of the libraries using flow cytometry yielded heterodimeric Fc variants with heterodimer-favoring CH3 domain interface mutation pairs, some of them showed high heterodimerization yields (~80-90% with previously unidentified CH3 domain interface mutation pairs, such as hydrogen bonds and cation-π interactions. Our study provides a new approach for engineering Fc heterodimers that could be used to engineer other heterodimeric protein-protein interactions through directed evolution combined with yeast surface display.

Revitalizing the Library OPAC: Interface, Searching, and Display Challenges

Directory of Open Access Journals (Sweden)

Jia Mi

2008-03-01

Full Text Available The behavior of academic library users has drastically changed in recent years. Internet search engines have become the preferred tool over the library online public access catalog (OPAC for finding information. Libraries are losing ground to online search engines. In this paper, two aspects of OPAC use are studied: (1 the current OPAC interface and searching capabilities, and (2 the OPAC bibliographic display. The purpose of the study is to find answers to the following questions: Why is the current OPAC ineffective? What can libraries and librarians do to deliver an OPAC that is as good as search engines to better serve our users? Revitalizing the library OPAC is one of the pressing issues that has to be accomplished.

Graphic displays on PCs of gaseous diffusion models of radionuclide releases to the atmosphere

International Nuclear Information System (INIS)

Campo Ortega, E. del

1993-01-01

The well-known MESOI program has been modified and improved to adapt it to a PC/AT with VGA colour monitor. Far from losing any of its powerful characteristics to calculate the transport, diffusion, deposition and decay of gaseous radioactive effluents discharged to the atmosphere, it has been enhanced to allow graphic viewing of concentrations, wind speed and direction and puff locations in colour, all on a background map of the site. The background covers a 75 x 75 km square and has a graphic grid density of 421 x 421 pixels. This means that effluent concentration is represented approximately every 170 metres in the 'clouded-area'. Among the modifications and enhancements made, the following are of particular interest: 1. A new subroutine called NUBE has been added, which calculates the distribution of effluent concentration of activity in a grid of 421 x 421 pixels. 2. Several subroutines have been added to obtain graphic displays and printouts of the cloud, wind field and puff locations. 3. Graphic display of the geographic plane of the area surrounding the effluent release point. 4. Off-line preparation of meteorological and topographical data files necessary for program execution. (author)

Real-time graphic display system for ROSA-V Large Scale Test Facility

International Nuclear Information System (INIS)

Kondo, Masaya; Anoda, Yoshinari; Osaki, Hideki; Kukita, Yutaka; Takigawa, Yoshio.

1993-11-01

A real-time graphic display system was developed for the ROSA-V Large Scale Test Facility (LSTF) experiments simulating accident management measures for prevention of severe core damage in pressurized water reactors (PWRs). The system works on an IBM workstation (Power Station RS/6000 model 560) and accommodates 512 channels out of about 2500 total measurements in the LSTF. It has three major functions: (a) displaying the coolant inventory distribution in the facility primary and secondary systems; (b) displaying the measured quantities at desired locations in the facility; and (c) displaying the time histories of measured quantities. The coolant inventory distribution is derived from differential pressure measurements along vertical sections and gamma-ray densitometer measurements for horizontal legs. The color display indicates liquid subcooling calculated from pressure and temperature at individual locations. (author)

A projection graphic display for the computer aided analysis of bubble chamber images

International Nuclear Information System (INIS)

Solomos, E.

1979-01-01

A projection graphic display for aiding the analysis of bubble chamber photographs has been developed by the Instrumentation Group of EF Division at CERN. The display image is generated on a very high brightness cathode ray tube and projected on to the table of the scanning-measuring machines as a superposition to the image of the bubble chamber. The display can send messages to the operator and aid the measurement by indicating directly on the chamber image the tracks which are measured correctly or not. (orig.)

A novel lentiviral scFv display library for rapid optimization and selection of high affinity antibodies.

Science.gov (United States)

Qudsia, Sehar; Merugu, Siva B; Mangukiya, Hitesh B; Hema, Negi; Wu, Zhenghua; Li, Dawei

2018-04-30

Antibody display libraries have become a popular technique to screen monoclonal antibodies for therapeutic purposes. An important aspect of display technology is to generate an optimization library by changing antibody affinity to antigen through mutagenesis and screening the high affinity antibody. In this study, we report a novel lentivirus display based optimization library antibody in which Agtuzumab scFv is displayed on cell membrane of HEK-293T cells. To generate an optimization library, hotspot mutagenesis was performed to achieve diverse antibody library. Based on sequence analysis of randomly selected clones, library size was estimated approximately to be 1.6 × 10 6 . Lentivirus display vector was used to display scFv antibody on cell surface and flow cytometery was performed to check the antibody affinity to antigen. Membrane bound scFv antibodies were then converted to secreted antibody through cre/loxP recombination. One of the mutant clones, M8 showed higher affinity to antigen in flow cytometery analysis. Further characterization of cellular and secreted scFv through western blot showed that antibody affinity was increased by three fold after mutagenesis. This study shows successful construction of a novel antibody library and suggests that hotspot mutagenesis could prove a useful and rapid optimization tool to generate similar libraries with various degree of antigen affinity. Copyright © 2018 Elsevier Inc. All rights reserved.

Visualization and computer graphics on isotropically emissive volumetric displays.

Science.gov (United States)

Mora, Benjamin; Maciejewski, Ross; Chen, Min; Ebert, David S

2009-01-01

The availability of commodity volumetric displays provides ordinary users with a new means of visualizing 3D data. Many of these displays are in the class of isotropically emissive light devices, which are designed to directly illuminate voxels in a 3D frame buffer, producing X-ray-like visualizations. While this technology can offer intuitive insight into a 3D object, the visualizations are perceptually different from what a computer graphics or visualization system would render on a 2D screen. This paper formalizes rendering on isotropically emissive displays and introduces a novel technique that emulates traditional rendering effects on isotropically emissive volumetric displays, delivering results that are much closer to what is traditionally rendered on regular 2D screens. Such a technique can significantly broaden the capability and usage of isotropically emissive volumetric displays. Our method takes a 3D dataset or object as the input, creates an intermediate light field, and outputs a special 3D volume dataset called a lumi-volume. This lumi-volume encodes approximated rendering effects in a form suitable for display with accumulative integrals along unobtrusive rays. When a lumi-volume is fed directly into an isotropically emissive volumetric display, it creates a 3D visualization with surface shading effects that are familiar to the users. The key to this technique is an algorithm for creating a 3D lumi-volume from a 4D light field. In this paper, we discuss a number of technical issues, including transparency effects due to the dimension reduction and sampling rates for light fields and lumi-volumes. We show the effectiveness and usability of this technique with a selection of experimental results captured from an isotropically emissive volumetric display, and we demonstrate its potential capability and scalability with computer-simulated high-resolution results.

Construction of human antibody gene libraries and selection of antibodies by phage display.

Science.gov (United States)

Frenzel, André; Kügler, Jonas; Wilke, Sonja; Schirrmann, Thomas; Hust, Michael

2014-01-01

Antibody phage display is the most commonly used in vitro selection technology and has yielded thousands of useful antibodies for research, diagnostics, and therapy.The prerequisite for successful generation and development of human recombinant antibodies using phage display is the construction of a high-quality antibody gene library. Here, we describe the methods for the construction of human immune and naive scFv gene libraries.The success also depends on the panning strategy for the selection of binders from these libraries. In this article, we describe a panning strategy that is high-throughput compatible and allows parallel selection in microtiter plates.

High performance interactive graphics for shower reconstruction in HPC, the DELPHI barrel electromagnetic calorimeter

International Nuclear Information System (INIS)

Stanescu, C.

1990-01-01

Complex software for shower reconstruction in DELPHI barrel electromagnetic calorimeter which deals, for each event, with great amounts of information, due to the high spatial resolution of this detector, needs powerful verification tools. An interactive graphics program, running on high performance graphics display system Whizzard 7555 from Megatek, was developed to display the logical steps in showers and their axes reconstruction. The program allows both operations on the image in real-time (rotation, translation and zoom) and the use of non-geometrical criteria to modify it (as the use of energy) thresholds for the representation of the elements that compound the showers (or of the associated lego plots). For this purpose graphics objects associated to user parameters were defined. Instancing and modelling features of the native graphics library were extensively used

Japanese Manga in Translation and American Graphic Novels: A Preliminary Examination of the Collections in 44 Academic Libraries

Science.gov (United States)

Masuchika, Glenn; Boldt, Gail

2010-01-01

American graphic novels are increasingly recognized as high-quality literature and an interesting genre for academic study. Graphic novels of Japan, called manga, have established a strong foothold in American culture. This preliminary survey of 44 United States university libraries demonstrates that Japanese manga in translation are consistently…

Visual, tangible, and touch-screen: Comparison of platforms for displaying simple graphics.

Science.gov (United States)

Gershon, Pnina; Klatzky, Roberta L; Palani, Hari; Giudice, Nicholas A

2016-01-01

Four different platforms were compared in a task of exploring an angular stimulus and reporting its value. The angle was explored visually, tangibly as raised fine-grit sandpaper, or on a touch-screen with a frictional or vibratory signal. All platforms produced highly accurate angle judgments. Differences were found, however, in exploration time, with vision fastest as expected, followed by tangible, vibration, and friction. Relative to the tangible display, touch-screens evidenced greater noise in the perceived angular value, with a particular disadvantage for friction. The latter must be interpreted in the context of a first-generation display and a rapidly advancing technology. On the whole, the results point both to promise and barriers in the use of refreshable graphical displays for blind users.

Corruption of phage-display libraries by target-unrelated clones: Diagnosis and countermeasures

Science.gov (United States)

Thomas, William D.; Golomb, Miriam; Smith, George P.

2010-01-01

Phage display is used to discover peptides or proteins with a desired target property—most often, affinity for a target selector molecule. Libraries of phage clones displaying diverse surface peptides are subject to a selection process designed to enrich for the target behavior, and subsequently propagated to restore phage numbers. A recurrent problem is enrichment of clones, called target-unrelated phage (TUPs), that lack the target behavior. Many TUPs are propagation-related; they have mutations conferring a growth advantage, and are enriched during the propagations accompanying selection. Unlike other filamentous phage libraries, fd-tet-based libraries are relatively resistant to propagation-related TUP corruption. Their minus strand origin is disrupted by a large cassette that simultaneously confers resistance to tetracycline and imposes a rate-limiting growth defect that cannot be bypassed with simple mutations. Nonetheless, a new type of propagation-related TUP emerged in the output of in vivo selections from an fd-tet library. The founding clone had a complex rearrangement that restored the minus strand origin while retaining tetracycline resistance. The rearrangement involved two recombination events, one with a contaminant having a wild-type minus strand origin. The founder’s infectivity advantage spread by simple recombination to clones displaying different peptides. We propose measures for minimizing TUP corruption. PMID:20692225

'SON-GO-KU' : a dream of automated library

Science.gov (United States)

Sato, Mamoru; Kishimoto, Juji

In the process of automating libraries, the retrieval of books through the browsing of shelves is being overlooked. The telematic library is a document based DBMS which can deliver the content of books by simulating the browsing process. The retrieval actually simulates the process a person would use in selecting a book in a real library, where a visual presentation using a graphic display is substituted. The characteristics of prototype system "Son-Go-Ku" for such retrieval implemented in 1988 are mentioned.

Wide-angle display developments by computer graphics

Science.gov (United States)

Fetter, William A.

1989-01-01

Computer graphics can now expand its new subset, wide-angle projection, to be as significant a generic capability as computer graphics itself. Some prior work in computer graphics is presented which leads to an attractive further subset of wide-angle projection, called hemispheric projection, to be a major communication media. Hemispheric film systems have long been present and such computer graphics systems are in use in simulators. This is the leading edge of capabilities which should ultimately be as ubiquitous as CRTs (cathode-ray tubes). These assertions are not from degrees in science or only from a degree in graphic design, but in a history of computer graphics innovations, laying groundwork by demonstration. The author believes that it is timely to look at several development strategies, since hemispheric projection is now at a point comparable to the early stages of computer graphics, requiring similar patterns of development again.

Elbereth. A soubroutine library for graphic representation from J.E.N. Fusion Division

International Nuclear Information System (INIS)

Guasp, J.

1981-01-01

A library for graphic representation, named Elbereth, has been built, all the subroutines have been written in Fortran-V for the Univac-1100/80 computer from J.E.N. and are able to produce drawing on the Calcomp-936 plotter, as well as with the printers and on the UTS-400 terminal screen. The library can yield two or three-dimensional plots as well as level lines, all of them under free format or in several standard ones either. It allows to be used on a simplified way by direct reading from a file. It has been constructed too with a flexible structure to allow forthcoming extensions. (author)

ELBERETH. A subroutine library for graphic representation from J. E. N. Fusion Division

International Nuclear Information System (INIS)

Guasp, J.

1981-01-01

A library for graphic representation, named ELBERETH, has been built, all the subroutines have been written in FORTRAN-V for the UN IVAC-1100/80 computers from JEN and are able to produce drawing on the CALCOMP-936 plotter, as well as with the printers and on the UTS-400 terminal screen. The library can yield two or three-dimensional plots as rail as level lines, all of them under free format or in several standard ones either. It allows to be used on a simplified way by direct reading from a file. It has been constructed too with a flexible structure to allow forth coming extensions. (Author) 4 refs

Corruption of phage display libraries by target-unrelated clones: diagnosis and countermeasures.

Science.gov (United States)

Thomas, William D; Golomb, Miriam; Smith, George P

2010-12-15

Phage display is used to discover peptides or proteins with a desired target property-most often, affinity for a target selector molecule. Libraries of phage clones displaying diverse surface peptides are subject to a selection process designed to enrich for the target behavior and subsequently propagated to restore phage numbers. A recurrent problem is enrichment of clones, called target-unrelated phages or peptides (TUPs), that lack the target behavior. Many TUPs are propagation related; they have mutations conferring a growth advantage and are enriched during the propagations accompanying selection. Unlike other filamentous phage libraries, fd-tet-based libraries are relatively resistant to propagation-related TUP corruption. Their minus-strand origin is disrupted by a large cassette that simultaneously confers resistance to tetracycline and imposes a rate-limiting growth defect that cannot be bypassed with simple mutations. Nonetheless, a new type of propagation-related TUP emerged in the output of in vivo selections from an fd-tet library. The founding clone had a complex rearrangement that restored the minus-strand origin while retaining tetracycline resistance. The rearrangement involved two recombination events, one with a contaminant having a wild-type minus-strand origin. The founder's infectivity advantage spread by simple recombination to clones displaying different peptides. We propose measures for minimizing TUP corruption. Copyright © 2010 Elsevier Inc. All rights reserved.

The Effect of Face-Front Display on the Circulation of Books in a Public Library.

Science.gov (United States)

Long, Sarah P.

This study considers the theories of impulse buying in an examination of the effects on circulation of library books when books are displayed face front (with all or most of the book jacket showing) as opposed to spine front. Reviews of the literature on consumer behavior and on library displays support the hypothesis of this study, i.e., that…

Phage-display libraries of murine and human antibody Fab fragments

DEFF Research Database (Denmark)

Engberg, J; Andersen, P S; Nielsen, L K

1996-01-01

We provide efficient and detailed procedures for construction, expression, and screening of comprehensive libraries of murine or human antibody Fab fragments displayed on the surface of filamentous phage. In addition, protocols for producing and using ultra-electrocompetent cells, for producing Fab...

Three-dimensional display by computer graphics method of hepatocellular carcinoma using seen with the hepatic arteriogram

International Nuclear Information System (INIS)

Itsubo, Mariko; Kameda, Haruo; Suzuki, Naoki; Okamura, Tetsuo

1989-01-01

The method of three-dimensional display of hepatocellular carcinoma using conventional hepatic arteriogram by computer graphics method was newly exploited and applied in clinical use. Three-dimensional models were reconstructed from contour lines of tumors demonstrated as hypervascular lesions by hepatic arteriography. Although objects were limited by angiographic images in which tumors need to be demonstrated as nodules with hypervascularity, this method of three-dimensional display was not worse on accuracy than that using computed tomographic images. According to this method property of the tumor expressed by vascularity was demonstrated clear and in addition volume of the tumor was calculated easily. When the tumor arose in necrotic changes in which demonstrated as a vascular lesion by hepatic arteriography with reduction of size in usual by conservative treatment such as transcathter arterial embolization therapy, this three-dimensional display was able to demonstrate such changes clear. This preliminary study demonstrates the feasibility and clinical usefulness of three-dimensional display of hepatocellular carcinoma using hepatic arteriogram by computer graphics method. (author)

Collection Of Software For Computer Graphics

Science.gov (United States)

Hibbard, Eric A.; Makatura, George

1990-01-01

Ames Research Graphics System (ARCGRAPH) collection of software libraries and software utilities assisting researchers in generating, manipulating, and visualizing graphical data. Defines metafile format containing device-independent graphical data. File format used with various computer-graphics-manipulation and -animation software packages at Ames, including SURF (COSMIC Program ARC-12381) and GAS (COSMIC Program ARC-12379). Consists of two-stage "pipeline" used to put out graphical primitives. ARCGRAPH libraries developed on VAX computer running VMS.

The Communicability of Graphical Alternatives to Tabular Displays of Statistical Simulation Studies

Science.gov (United States)

Cook, Alex R.; Teo, Shanice W. L.

2011-01-01

Simulation studies are often used to assess the frequency properties and optimality of statistical methods. They are typically reported in tables, which may contain hundreds of figures to be contrasted over multiple dimensions. To assess the degree to which these tables are fit for purpose, we performed a randomised cross-over experiment in which statisticians were asked to extract information from (i) such a table sourced from the literature and (ii) a graphical adaptation designed by the authors, and were timed and assessed for accuracy. We developed hierarchical models accounting for differences between individuals of different experience levels (under- and post-graduate), within experience levels, and between different table-graph pairs. In our experiment, information could be extracted quicker and, for less experienced participants, more accurately from graphical presentations than tabular displays. We also performed a literature review to assess the prevalence of hard-to-interpret design features in tables of simulation studies in three popular statistics journals, finding that many are presented innumerately. We recommend simulation studies be presented in graphical form. PMID:22132184

Topographic Information Requirements and Computer-Graphic Display Techniques for Nap-of-the-Earth Flight.

Science.gov (United States)

1979-12-01

of- at Battle Positions sight to target when unmask Concealment of Approach Map j Routes ! I i. 16 ... ’ FUNCTION: IASb SELECT AERIAL OBSERVATION...to select special overlays for temporary display and to remove them for clutter avoidance. In addition to these graphic presentation roles , the

PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries.

Science.gov (United States)

Shave, Steven; Mann, Stefan; Koszela, Joanna; Kerr, Alastair; Auer, Manfred

2018-01-01

The design of highly diverse phage display libraries is based on assumption that DNA bases are incorporated at similar rates within the randomized sequence. As library complexity increases and expected copy numbers of unique sequences decrease, the exploration of library space becomes sparser and the presence of truly random sequences becomes critical. We present the program PuLSE (Phage Library Sequence Evaluation) as a tool for assessing randomness and therefore diversity of phage display libraries. PuLSE runs on a collection of sequence reads in the fastq file format and generates tables profiling the library in terms of unique DNA sequence counts and positions, translated peptide sequences, and normalized 'expected' occurrences from base to residue codon frequencies. The output allows at-a-glance quantitative quality control of a phage library in terms of sequence coverage both at the DNA base and translated protein residue level, which has been missing from toolsets and literature. The open source program PuLSE is available in two formats, a C++ source code package for compilation and integration into existing bioinformatics pipelines and precompiled binaries for ease of use.

Novel Zn2+-chelating peptides selected from a fimbria-displayed random peptide library

DEFF Research Database (Denmark)

Kjærgaard, Kristian; Schembri, Mark; Klemm, Per

2001-01-01

The display of peptide sequences on the surface of bacteria is a technology that offers exciting applications in biotechnology and medical research. Type 1 fimbriae are surface organelles of Escherichia coli which mediate D-mannose-sensitive binding to different host surfaces by virtue of the Fim......H adhesin. FimH is a component of the fimbrial organelle that can accommodate and display a diverse range of peptide sequences on the E. coli cell surface. In this study we have constructed a random peptide library in FimH. The library, consisting of similar to 40 million individual clones, was screened...

ShelXle: a Qt graphical user interface for SHELXL.

Science.gov (United States)

Hübschle, Christian B; Sheldrick, George M; Dittrich, Birger

2011-12-01

ShelXle is a graphical user interface for SHELXL [Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122], currently the most widely used program for small-molecule structure refinement. It combines an editor with syntax highlighting for the SHELXL-associated .ins (input) and .res (output) files with an interactive graphical display for visualization of a three-dimensional structure including the electron density (F(o)) and difference density (F(o)-F(c)) maps. Special features of ShelXle include intuitive atom (re-)naming, a strongly coupled editor, structure visualization in various mono and stereo modes, and a novel way of displaying disorder extending over special positions. ShelXle is completely compatible with all features of SHELXL and is written entirely in C++ using the Qt4 and FFTW libraries. It is available at no cost for Windows, Linux and Mac-OS X and as source code.

Rapid and Direct VHH and Target Identification by Staphylococcal Surface Display Libraries

Directory of Open Access Journals (Sweden)

Marco Cavallari

2017-07-01

Full Text Available Unbiased and simultaneous identification of a specific antibody and its target antigen has been difficult without prior knowledge of at least one interaction partner. Immunization with complex mixtures of antigens such as whole organisms and tissue extracts including tumoral ones evokes a highly diverse immune response. During such a response, antibodies are generated against a variety of epitopes in the mixture. Here, we propose a surface display design that is suited to simultaneously identify camelid single domain antibodies and their targets. Immune libraries of single-domain antigen recognition fragments from camelid heavy chain-only antibodies (VHH were attached to the peptidoglycan of Gram-positive Staphylococcus aureus employing its endogenous housekeeping sortase enzyme. The sortase transpeptidation reaction covalently attached the VHH to the bacterial peptidoglycan. The reversible nature of the reaction allowed the recovery of the VHH from the bacterial surface and the use of the VHH in downstream applications. These staphylococcal surface display libraries were used to rapidly identify VHH as well as their targets by immunoprecipitation (IP. Our novel bacterial surface display platform was stable under harsh screening conditions, allowed fast target identification, and readily permitted the recovery of the displayed VHH for downstream analysis.

The Xamine online/offline display program

International Nuclear Information System (INIS)

Fox, R.; Vander Molen, A.

1996-01-01

The authors report on the design, development and stage-wise deployment of a new histogram display subsystem at the National Superconducting Cyclotron Laboratory (NSCL). This subsystem is based on the X/Motif graphical user interface library. The development cycle and feature set of this subsystem are described. The authors describe why they felt it was necessary to write a new package rather than to work with existing packages. The paper will also discuss the communication between the client and Xamine. This communications allows Xamine to cooperate with client programs providing the illusion of a unified GUI shared between the display subsystem and the client program

Designing a Visual Factors-Based Screen Display Interface: The New Role of the Graphic Technologist.

Science.gov (United States)

Faiola, Tony; DeBloois, Michael L.

1988-01-01

Discusses the role of the graphic technologist in preparing computer screen displays for interactive videodisc systems, and suggests screen design guidelines. Topics discussed include the grid system; typography; visual factors research; color; course mobility through branching and software menus; and a model of course integration. (22 references)…

BNL325 - Nuclear reaction data display program

International Nuclear Information System (INIS)

Dunford, C.L.

1994-01-01

A computer code for the graphical display of nuclear reaction data is described. The code, which works on a computer with VMS operating system, can overlay experimental data from an EXFOR/CSISRS table-computation format with evaluated data from ENDF formatted data libraries. Originally, this code has been used at the U.S. National Nuclear Data Center to produce the well-known neutron cross-section atlas published as report BNL-325. (author). 3 tabs

BNL325 - Nuclear reaction data display program

Energy Technology Data Exchange (ETDEWEB)

Dunford, C L

1994-11-27

A computer code for the graphical display of nuclear reaction data is described. The code, which works on a computer with VMS operating system, can overlay experimental data from an EXFOR/CSISRS table-computation format with evaluated data from ENDF formatted data libraries. Originally, this code has been used at the U.S. National Nuclear Data Center to produce the well-known neutron cross-section atlas published as report BNL-325. (author). 3 tabs.

Graphic filter library implemented in CUDA language

OpenAIRE

Peroutková, Hedvika

2009-01-01

This thesis deals with the problem of reducing computation time of raster image processing by parallel computing on graphics processing unit. Raster image processing thereby refers to the application of graphic filters, which can be applied in sequence with different settings. This thesis evaluates the suitability of using parallelization on graphic card for raster image adjustments based on multicriterial choice. Filters are implemented for graphics processing unit in CUDA language. Opacity ...

A handbook of statistical graphics using SAS ODS

CERN Document Server

Der, Geoff

2014-01-01

An Introduction to Graphics: Good Graphics, Bad Graphics, Catastrophic Graphics and Statistical GraphicsThe Challenger DisasterGraphical DisplaysA Little History and Some Early Graphical DisplaysGraphical DeceptionAn Introduction to ODS GraphicsGenerating ODS GraphsODS DestinationsStatistical Graphics ProceduresODS Graphs from Statistical ProceduresControlling ODS GraphicsControlling Labelling in GraphsODS Graphics EditorGraphs for Displaying the Characteristics of Univariate Data: Horse Racing, Mortality Rates, Forearm Lengths, Survival Times and Geyser EruptionsIntroductionPie Chart, Bar Cha

Biomathematical Description of Synthetic Peptide Libraries

Science.gov (United States)

Trepel, Martin

2015-01-01

Libraries of randomised peptides displayed on phages or viral particles are essential tools in a wide spectrum of applications. However, there is only limited understanding of a library's fundamental dynamics and the influences of encoding schemes and sizes on their quality. Numeric properties of libraries, such as the expected number of different peptides and the library's coverage, have long been in use as measures of a library's quality. Here, we present a graphical framework of these measures together with a library's relative efficiency to help to describe libraries in enough detail for researchers to plan new experiments in a more informed manner. In particular, these values allow us to answer-in a probabilistic fashion-the question of whether a specific library does indeed contain one of the "best" possible peptides. The framework is implemented in a web-interface based on two packages, discreteRV and peptider, to the statistical software environment R. We further provide a user-friendly web-interface called PeLiCa (Peptide Library Calculator, http://www.pelica.org), allowing scientists to plan and analyse their peptide libraries. PMID:26042419

Generating high gray-level resolution monochrome displays with conventional computer graphics cards and color monitors.

Science.gov (United States)

Li, Xiangrui; Lu, Zhong-Lin; Xu, Pengjing; Jin, Jianzhong; Zhou, Yifeng

2003-11-30

Display systems based on conventional computer graphics cards are capable of generating images with about 8-bit luminance resolution. However, most vision experiments require more than 12 bits of luminance resolution. Pelli and Zhang [Spatial Vis. 10 (1997) 443] described a video attenuator for generating high luminance resolution displays on a monochrome monitor, or for driving just the green gun of a color monitor. Here we show how to achieve a white display by adding video amplifiers to duplicate the monochrome signal to drive all three guns of any color monitor. Because of the lack of the availability of high quality monochrome monitors, our method provides an inexpensive way to achieve high-resolution monochromatic displays using conventional, easy-to-get equipment. We describe the design principles, test results, and a few additional functionalities.

An Evaluation of the Interactive Query Expansion in an Online Library Catalogue with a Graphical User Interface.

Science.gov (United States)

Hancock-Beaulieu, Micheline; And Others

1995-01-01

An online library catalog was used to evaluate an interactive query expansion facility based on relevance feedback for the Okapi, probabilistic, term weighting, retrieval system. A graphical user interface allowed searchers to select candidate terms extracted from relevant retrieved items to reformulate queries. Results suggested that the…

Performance evaluation of phage-displayed synthetic human single-domain antibody libraries: A retrospective analysis.

Science.gov (United States)

Henry, Kevin A; Tanha, Jamshid

2018-05-01

Fully human synthetic single-domain antibodies (sdAbs) are desirable therapeutic molecules but their development is a considerable challenge. Here, using a retrospective analysis of in-house historical data, we examined the parameters that impact the outcome of screening phage-displayed synthetic human sdAb libraries to discover antigen-specific binders. We found no evidence for a differential effect of domain type (V H or V L ), library randomization strategy, incorporation of a stabilizing disulfide linkage or sdAb display format (monovalent vs. multivalent) on the probability of obtaining any antigen-binding human sdAbs, instead finding that the success of library screens was primarily related to properties of target antigens, especially molecular mass. The solubility and binding affinity of sdAbs isolated from successful screens depended both on properties of the sdAb libraries (primarily domain type) and the target antigens. Taking attrition of sdAbs with major manufacturability concerns (aggregation; low expression) and sdAbs that do not recognize native cell-surface antigens as independent probabilities, we calculate the overall likelihood of obtaining ≥1 antigen-binding human sdAb from a single library-target screen as ~24%. Successful library-target screens should be expected to yield ~1.3 human sdAbs on average, each with average binding affinity of ~2 μM. Copyright © 2018 Elsevier B.V. All rights reserved.

Evaluation of an integrated graphical display to promote acute change detection in ICU patients

Science.gov (United States)

Anders, Shilo; Albert, Robert; Miller, Anne; Weinger, Matthew B.; Doig, Alexa K.; Behrens, Michael; Agutter, Jim

2012-01-01

Objective The purpose of this study was to evaluate ICU nurses’ ability to detect patient change using an integrated graphical information display (IGID) versus a conventional tabular ICU patient information display (i.e. electronic chart). Design Using participants from two different sites, we conducted a repeated measures simulator-based experiment to assess ICU nurses’ ability to detect abnormal patient variables using a novel IGID versus a conventional tabular information display. Patient scenarios and display presentations were fully counterbalanced. Measurements We measured percent correct detection of abnormal patient variables, nurses’ perceived workload (NASA-TLX), and display usability ratings. Results 32 ICU nurses (87% female, median age of 29 years, and median ICU experience of 2.5 years) using the IGID detected more abnormal variables compared to the tabular display [F (1,119)=13.0, p < 0.05]. There was a significant main effect of site [F (1, 119)=14.2], with development site participants doing better. There were no significant differences in nurses’ perceived workload. The IGID display was rated as more usable than the conventional display, [F (1, 60)=31.7]. Conclusion Overall, nurses reported more important physiological information with the novel IGID than tabular display. Moreover, the finding of site differences may reflect local influences in work practice and involvement in iterative display design methodology. Information displays developed using user-centered design should accommodate the full diversity of the intended user population across use sites. PMID:22534099

Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library

Directory of Open Access Journals (Sweden)

Goldman Ellen R

2007-11-01

Full Text Available Abstract Background Shark heavy chain antibody, also called new antigen receptor (NAR, consists of one single Variable domain (VH, containing only two complementarity-determining regions (CDRs. The antigen binding affinity and specificity are mainly determined by these two CDRs. The good solubility, excellent thermal stability and complex sequence variation of small single domain antibodies (sdAbs make them attractive alternatives to conventional antibodies. In this report, we construct and characterize a diversity enhanced semi-synthetic NAR V display library based on naturally occurring NAR V sequences. Results A semi-synthetic shark sdAb display library with a complexity close to 1e9 was constructed. This was achieved by introducing size and sequence variations in CDR3 using randomized CDR3 primers of three different lengths. Binders against three toxins, staphylococcal enterotoxin B (SEB, ricin, and botulinum toxin A (BoNT/A complex toxoid, were isolated from panning the display library. Soluble sdAbs from selected binders were purified and evaluated using direct binding and thermal stability assays on the Luminex 100. In addition, sandwich assays using sdAb as the reporter element were developed to demonstrate their utility for future sensor applications. Conclusion We demonstrated the utility of a newly created hyper diversified shark NAR displayed library to serve as a source of thermal stable sdAbs against a variety of toxins.

Modular and aggregation resistant Vh antibodies from a phage display library

DEFF Research Database (Denmark)

Friis, Niels Anton; Mandrup, Ole Aalund; Lykkemark, Simon

2012-01-01

through immunisation of sharks or camels, or alternatively from recombinant libraries1. The domain antibodies have certain advantages, both pharmacologically and technically. Here we report the construction of a semi-synthetic and highly modular antibody library, based on a human framework (V3-23/D47......Directed evolution of antibodies through phage display is a powerful technique for producing binders of various biological targets. One of the recent innovations in the fi eld is the domain antibody, an antibody consisting only of a single variable domain. These anti bodies can be obtained either......). The antibody scaffold has been codon optimised to improve expression, and the CDR’s have been created using trinucleotide synthesis. These methods give a strict control over the randomisations, and the ability to design a library with minimal aggregation propensity. To facilitate further manipulation, unique...

Graphical interpretation of numerical model results

International Nuclear Information System (INIS)

Drewes, D.R.

1979-01-01

Computer software has been developed to produce high quality graphical displays of data from a numerical grid model. The code uses an existing graphical display package (DISSPLA) and overcomes some of the problems of both line-printer output and traditional graphics. The software has been designed to be flexible enough to handle arbitrarily placed computation grids and a variety of display requirements

Analog-to-digital clinical data collection on networked workstations with graphic user interface.

Science.gov (United States)

Lunt, D

1991-02-01

An innovative respiratory examination system has been developed that combines physiological response measurement, real-time graphic displays, user-driven operating sequences, and networked file archiving and review into a scientific research and clinical diagnosis tool. This newly constructed computer network is being used to enhance the research center's ability to perform patient pulmonary function examinations. Respiratory data are simultaneously acquired and graphically presented during patient breathing maneuvers and rapidly transformed into graphic and numeric reports, suitable for statistical analysis or database access. The environment consists of the hardware (Macintosh computer, MacADIOS converters, analog amplifiers), the software (HyperCard v2.0, HyperTalk, XCMDs), and the network (AppleTalk, fileservers, printers) as building blocks for data acquisition, analysis, editing, and storage. System operation modules include: Calibration, Examination, Reports, On-line Help Library, Graphic/Data Editing, and Network Storage.

Graphic user interface for COSMOS code

International Nuclear Information System (INIS)

Oh, Je Yong; Koo, Yang Hyun; Lee, Byung Ho; Cheon, Jin Sik; Sohn, Dong Seong

2003-06-01

The Graphic User Interface (GUI) - which consisted of graphical elements such as windows, menu, button, icon, and so on - made it possible that the computer could be easily used for common users. Hence, the GUI was introduced to improve the efficiency to input parameters in COSMOS code. The functions to output graphs on the screen and postscript files were also added. And the graph library can be applied to the other codes. The details of principles of GUI and graphic library were described in the report

User's guide to the CALVEC software library: a computer program for emulation of CALCOMP graphics on a Versatec printer/plotter

International Nuclear Information System (INIS)

Gray, W.H.

1978-08-01

This document describes a set of FORTRAN subroutines collectively called the CALVEC subprogram library. The purpose of the CALVEC software library is the emulation of CALCOMP pen and ink graphics on a DECsystem 10. A user level interface with CALVEC software allows standard CALCOMP subprogram calls to produce a VECtor file, SEGMNT.VEC. This vector file may subsequently be postprocessed into an image in a variety of ways

User's guide to the CALVEC software library: a computer program for emulation of CALCOMP graphics on a versatec printer/plotter

International Nuclear Information System (INIS)

Gray, W.H.

1979-03-01

this document describes a set of FORTRAN subroutines collectively called the CALVEC subprogram library. The purpose of the CALVEC software library is the emulation of CALCOMP pen and ink graphics on a DECsystem 10. A user level interface with CALVEC software allows standard CALCOMP subprogram calls to produce a VECtor file, FOR24.VEC. This vector file may subsequently be postprocessed into an image in a variety of ways

Construction of naïve camelids VHH repertoire in phage display-based library.

Science.gov (United States)

Sabir, Jamal S M; Atef, Ahmed; El-Domyati, Fotouh M; Edris, Sherif; Hajrah, Nahid; Alzohairy, Ahmed M; Bahieldin, Ahmed

2014-04-01

Camelids have unique antibodies, namely HCAbs (VHH) or commercially named Nanobodies(®) (Nb) that are composed only of a heavy-chain homodimer. As libraries based on immunized camelids are time-consuming, costly and likely redundant for certain antigens, we describe the construction of a naïve camelid VHHs library from blood serum of non-immunized camelids with affinity in the subnanomolar range and suitable for standard immune applications. This approach is rapid and recovers VHH repertoire with the advantages of being more diverse, non-specific and devoid of subpopulations of specific antibodies, which allows the identification of binders for any potential antigen (or pathogen). RNAs from a number of camelids from Saudi Arabia were isolated and cDNAs of the diverse vhh gene were amplified; the resulting amplicons were cloned in the phage display pSEX81 vector. The size of the library was found to be within the required range (10(7)) suitable for subsequent applications in disease diagnosis and treatment. Two hundred clones were randomly selected and the inserted gene library was either estimated for redundancy or sequenced and aligned to the reference camelid vhh gene (acc. No. ADE99145). Results indicated complete non-specificity of this small library in which no single event of redundancy was detected. These results indicate the efficacy of following this approach in order to yield a large and diverse enough gene library to secure the presence of the required version encoding the required antibodies for any target antigen. This work is a first step towards the construction of phage display-based biosensors useful in disease (e.g., TB or tuberculosis) diagnosis and treatment. Copyright © 2014 Académie des sciences. Published by Elsevier SAS. All rights reserved.

A computer program with graphical user interface to plot the multigroup cross sections of WIMS-D library

International Nuclear Information System (INIS)

Thiyagarajan, T.K.; Ganesan, S.; Jagannathan, V.; Karthikeyan, R.

2002-01-01

As a result of the IAEA Co-ordinated Research Programme entitled 'Final Stage of the WIMS Library Update Project', new and updated WIMS-D libraries based upon ENDF/B-VI.5, JENDL-3.2 and JEF-2.2 have become available. A project to prepare an exhaustive handbook of WIMS-D cross sections from old and new libraries has been taken up by the authors. As part of this project, we have developed a computer program XnWlup with user-friendly graphical interface to help the users of WIMS-D library to enable quick visualization of the plots of the energy dependence of the multigroup cross sections of any nuclide of interest. This software enables the user to generate and view the histogram of 69 multi-group cross sections as a function of neutron energy under Microsoft Windows environment. This software is designed using Microsoft Visual C++ and Microsoft Foundation Classes Library. The current features of the software, on-line help manual and future plans for further development are described in this paper

Virtual reality hardware and graphic display options for brain-machine interfaces.

Science.gov (United States)

Marathe, Amar R; Carey, Holle L; Taylor, Dawn M

2008-01-15

Virtual reality hardware and graphic displays are reviewed here as a development environment for brain-machine interfaces (BMIs). Two desktop stereoscopic monitors and one 2D monitor were compared in a visual depth discrimination task and in a 3D target-matching task where able-bodied individuals used actual hand movements to match a virtual hand to different target hands. Three graphic representations of the hand were compared: a plain sphere, a sphere attached to the fingertip of a realistic hand and arm, and a stylized pacman-like hand. Several subjects had great difficulty using either stereo monitor for depth perception when perspective size cues were removed. A mismatch in stereo and size cues generated inappropriate depth illusions. This phenomenon has implications for choosing target and virtual hand sizes in BMI experiments. Target-matching accuracy was about as good with the 2D monitor as with either 3D monitor. However, users achieved this accuracy by exploring the boundaries of the hand in the target with carefully controlled movements. This method of determining relative depth may not be possible in BMI experiments if movement control is more limited. Intuitive depth cues, such as including a virtual arm, can significantly improve depth perception accuracy with or without stereo viewing.

A Module for Graphical Display of Model Results with the CBP Toolbox

Energy Technology Data Exchange (ETDEWEB)

Smith, F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2015-04-21

This report describes work performed by the Savannah River National Laboratory (SRNL) in fiscal year 2014 to add enhanced graphical capabilities to display model results in the Cementitious Barriers Project (CBP) Toolbox. Because Version 2.0 of the CBP Toolbox has just been released, the graphing enhancements described in this report have not yet been integrated into a new version of the Toolbox. Instead they have been tested using a standalone GoldSim model and, while they are substantially complete, may undergo further refinement before full implementation. Nevertheless, this report is issued to document the FY14 development efforts which will provide a basis for further development of the CBP Toolbox.

IAU Graphics Extension - Gnu C

DEFF Research Database (Denmark)

Denver, Troelz; Jørgensen, John Leif; Riis, Troels

1999-01-01

This document contains a description of the library GrxIau (former UtilVesa and UTILLE). The library acts as shell to the graphics commands used at the exercises at the course 50240 Image Analysis with Microcomputers....

Critical frameworks for graphic design: graphic design and visual culture

OpenAIRE

Dauppe, Michele-Anne

2011-01-01

The paper considers an approach to the study of graphic design which addresses the expanding nature of graphic design in the 21st century and the purposeful application of theory to the subject of graphic design. In recent years graphic design has expanded its domain from the world of print culture (e.g. books, posters) into what is sometimes called screen culture. Everything from a mobile phone to a display in an airport lounge to the A.T.M. carries graphic design. It has become ever more ub...

Book Display as Adult Service

Directory of Open Access Journals (Sweden)

Matthew S. Moore

1997-03-01

Full Text Available 無Book display as an adult service is defined as choosing and positioning adult books from the collection to increase their circulation. The author contrasts bookstore arrangement for sales versus library arrangement for access. The paper considers the library-as-a-whole as a display, examines the right size for an in-library display, and discusses mass displays, end-caps, on-shelf displays, and the Tiffany approach. The author proposes that an effective display depends on an imaginative, unifying theme, and that book displays are part of the joy of libraries.

Stereoscopic 3D graphics generation

Science.gov (United States)

Li, Zhi; Liu, Jianping; Zan, Y.

1997-05-01

Stereoscopic display technology is one of the key techniques of areas such as simulation, multimedia, entertainment, virtual reality, and so on. Moreover, stereoscopic 3D graphics generation is an important part of stereoscopic 3D display system. In this paper, at first, we describe the principle of stereoscopic display and summarize some methods to generate stereoscopic 3D graphics. Secondly, to overcome the problems which came from the methods of user defined models (such as inconvenience, long modifying period and so on), we put forward the vector graphics files defined method. Thus we can design more directly; modify the model simply and easily; generate more conveniently; furthermore, we can make full use of graphics accelerator card and so on. Finally, we discuss the problem of how to speed up the generation.

An interactive graphics program to retrieve, display, compare, manipulate, curve fit, difference and cross plot wind tunnel data

Science.gov (United States)

Elliott, R. D.; Werner, N. M.; Baker, W. M.

1975-01-01

The Aerodynamic Data Analysis and Integration System (ADAIS), developed as a highly interactive computer graphics program capable of manipulating large quantities of data such that addressable elements of a data base can be called up for graphic display, compared, curve fit, stored, retrieved, differenced, etc., was described. The general nature of the system is evidenced by the fact that limited usage has already occurred with data bases consisting of thermodynamic, basic loads, and flight dynamics data. Productivity using ADAIS of five times that for conventional manual methods of wind tunnel data analysis is routinely achieved. In wind tunnel data analysis, data from one or more runs of a particular test may be called up and displayed along with data from one or more runs of a different test. Curves may be faired through the data points by any of four methods, including cubic spline and least squares polynomial fit up to seventh order.

Zap! Pow! Wham!: Comics, Graphic Novels, and Education.

Science.gov (United States)

Barron, Daniel D.

1991-01-01

Discussion of the use of comic books and graphic novels in school and public libraries highlights the role of school library media programs; how to use comics and graphic novels in teaching; the Japanese use of comic books; their use in literacy education; and the influence of comics on reading habits. (LRW)

Three Dimensional Computer Graphics Federates for the 2012 Smackdown Simulation

Science.gov (United States)

Fordyce, Crystal; Govindaiah, Swetha; Muratet, Sean; O'Neil, Daniel A.; Schricker, Bradley C.

2012-01-01

The Simulation Interoperability Standards Organization (SISO) Smackdown is a two-year old annual event held at the 2012 Spring Simulation Interoperability Workshop (SIW). A primary objective of the Smackdown event is to provide college students with hands-on experience in developing distributed simulations using High Level Architecture (HLA). Participating for the second time, the University of Alabama in Huntsville (UAHuntsville) deployed four federates, two federates simulated a communications server and a lunar communications satellite with a radio. The other two federates generated 3D computer graphics displays for the communication satellite constellation and for the surface based lunar resupply mission. Using the Light-Weight Java Graphics Library, the satellite display federate presented a lunar-texture mapped sphere of the moon and four Telemetry Data Relay Satellites (TDRS), which received object attributes from the lunar communications satellite federate to drive their motion. The surface mission display federate was an enhanced version of the federate developed by ForwardSim, Inc. for the 2011 Smackdown simulation. Enhancements included a dead-reckoning algorithm and a visual indication of which communication satellite was in line of sight of Hadley Rille. This paper concentrates on these two federates by describing the functions, algorithms, HLA object attributes received from other federates, development experiences and recommendations for future, participating Smackdown teams.

ATM Technology Demonstration-1 Phase II Boeing Configurable Graphical Display (CGD) Software Design Description

Science.gov (United States)

Wilber, George F.

2017-01-01

This Software Description Document (SDD) captures the design for developing the Flight Interval Management (FIM) system Configurable Graphics Display (CGD) software. Specifically this SDD describes aspects of the Boeing CGD software and the surrounding context and interfaces. It does not describe the Honeywell components of the CGD system. The SDD provides the system overview, architectural design, and detailed design with all the necessary information to implement the Boeing components of the CGD software and integrate them into the CGD subsystem within the larger FIM system. Overall system and CGD system-level requirements are derived from the CGD SRS (in turn derived from the Boeing System Requirements Design Document (SRDD)). Display and look-and-feel requirements are derived from Human Machine Interface (HMI) design documents and working group recommendations. This Boeing CGD SDD is required to support the upcoming Critical Design Review (CDR).

Compositional Bias in Naïve and Chemically-modified Phage-Displayed Libraries uncovered by Paired-end Deep Sequencing.

Science.gov (United States)

He, Bifang; Tjhung, Katrina F; Bennett, Nicholas J; Chou, Ying; Rau, Andrea; Huang, Jian; Derda, Ratmir

2018-01-19

Understanding the composition of a genetically-encoded (GE) library is instrumental to the success of ligand discovery. In this manuscript, we investigate the bias in GE-libraries of linear, macrocyclic and chemically post-translationally modified (cPTM) tetrapeptides displayed on the M13KE platform, which are produced via trinucleotide cassette synthesis (19 codons) and NNK-randomized codon. Differential enrichment of synthetic DNA {S}, ligated vector {L} (extension and ligation of synthetic DNA into the vector), naïve libraries {N} (transformation of the ligated vector into the bacteria followed by expression of the library for 4.5 hours to yield a "naïve" library), and libraries chemically modified by aldehyde ligation and cysteine macrocyclization {M} characterized by paired-end deep sequencing, detected a significant drop in diversity in {L} → {N}, but only a minor compositional difference in {S} → {L} and {N} → {M}. Libraries expressed at the N-terminus of phage protein pIII censored positively charged amino acids Arg and Lys; libraries expressed between pIII domains N1 and N2 overcame Arg/Lys-censorship but introduced new bias towards Gly and Ser. Interrogation of biases arising from cPTM by aldehyde ligation and cysteine macrocyclization unveiled censorship of sequences with Ser/Phe. Analogous analysis can be used to explore library diversity in new display platforms and optimize cPTM of these libraries.

LOOM-P: a finite element mesh generation program with on-line graphic display

International Nuclear Information System (INIS)

Ise, Takeharu; Yamazaki, Toshio.

1977-06-01

A description of the two-dimensional mesh generation program, LOOM-P, is given in detail. The program is developed newly to produce a mesh network for a reactor core geometry with the help of an automatic mesh generation routine built in it, under the control of the refresh-type graphic display. It is therefore similar to the edit program of the self-organizing mesh generator, QMESH-RENUM. Additional techniques are incorporated to improve the pattern of mesh elements by means of on-line conversational mode. The obtained mesh network is edited out as input data to the three-dimensional neutron diffusion theory code, FEM-BABEL. (auth.)

Reactor FaceMap Tool: A modern graphics tool for displaying reactor data

International Nuclear Information System (INIS)

Roberts, J.C.

1991-01-01

A prominent graphical user interface in reactor physics applications at the Savannah River Site is the reactor facemap display. This is a two dimensional view of a cross section of a reactor. In the past each application which needed a facemap implemented its own version. Thus, none of the code was reused, the facemap implementation was hardware dependent and the user interface was different for each facemap. The Reactor FaceMap Tool was built to solve these problems. Through the use of modern computing technologies such as X Windows, object-oriented programming and client/server technology the Reactor FaceMap Tool has the flexibility to work in many diverse applications and the portability to run on numerous types of hardware

Diagrams and Relational Maps: The Use of Graphic Elicitation Techniques with Interviewing for Data Collection, Analysis, and Display

Directory of Open Access Journals (Sweden)

Andrea J. Copeland PhD

2012-12-01

Full Text Available Graphic elicitation techniques, which ask research participants to provide visual data representing personal understandings of concepts, experiences, beliefs, or behaviors, can be especially useful in helping participants to express complex or abstract ideas or opinions. The benefits and drawbacks of using graphic elicitation techniques for data collection, data analysis, and data display in qualitative research studies are analyzed using examples from a research study that employed data matrices and relational maps in conjunction with semi-structured interviews. Results from this analysis demonstrate that the use of these combined techniques for data collection facilitates triangulation and helps to establish internal consistency of data, thereby increasing the trustworthiness of the interpretation of that data and lending support to validity and reliability claims. Findings support the notion that graphic elicitation techniques can be highly useful in qualitative research studies at the data collection, the data analysis, and the data reporting stages. For example, this study found that graphic elicitation techniques are especially useful for eliciting data related to emotions and emotional experiences.

HLYWD: a program for post-processing data files to generate selected plots or time-lapse graphics

International Nuclear Information System (INIS)

Munro, J.K. Jr.

1980-05-01

The program HLYWD is a post-processor of output files generated by large plasma simulation computations or of data files containing a time sequence of plasma diagnostics. It is intended to be used in a production mode for either type of application; i.e., it allows one to generate along with the graphics sequence, segments containing title, credits to those who performed the work, text to describe the graphics, and acknowledgement of funding agency. The current version is designed to generate 3D plots and allows one to select type of display (linear or semi-log scales), choice of normalization of function values for display purposes, viewing perspective, and an option to allow continuous rotations of surfaces. This program was developed with the intention of being relatively easy to use, reasonably flexible, and requiring a minimum investment of the user's time. It uses the TV80 library of graphics software and ORDERLIB system software on the CDC 7600 at the National Magnetic Fusion Energy Computing Center at Lawrence Livermore Laboratory in California

2 D 1/2 graphical benchmark

International Nuclear Information System (INIS)

Brochard, P.; Colin De Verdiere, G.; Nomine, J.P.; Perros, J.P.

1993-01-01

Within the framework of the development of a new version of the Psyche software, the author reports a benchmark study on different graphical libraries and systems and on the Psyche application. The author outlines the current context of development of graphical tools which still lacks of standardisation. This makes the comparison somehow limited and finally related to envisaged applications. The author presents the various systems and libraries, test principles, and characteristics of machines. Results and interpretations are then presented with reference to faced problems

Alarm annunciation in a graphical environment

International Nuclear Information System (INIS)

Adams, D.G.

1994-01-01

Well-designed graphical user interfaces, such as Microsoft reg-sign Windows trademark or UNIX trademark--based X-Windows reg-sign, provide a capability for enhanced display of security alarm information. Conversely, a poorly designed interface can quickly overwhelm an operator. This paper describes types of graphical information that can be displayed and offers guidance on how to best display that information. Limits are proposed for the complexity of the user interface, and guidelines are suggested for the display of maps and sensors

Graphics gems

CERN Document Server

Heckbert, Paul S

1994-01-01

Graphics Gems IV contains practical techniques for 2D and 3D modeling, animation, rendering, and image processing. The book presents articles on polygons and polyhedral; a mix of formulas, optimized algorithms, and tutorial information on the geometry of 2D, 3D, and n-D space; transformations; and parametric curves and surfaces. The text also includes articles on ray tracing; shading 3D models; and frame buffer techniques. Articles on image processing; algorithms for graphical layout; basic interpolation methods; and subroutine libraries for vector and matrix algebra are also demonstrated. Com

Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positions.

Science.gov (United States)

Naumer, Matthias; Ying, Ying; Michelfelder, Stefan; Reuter, Antje; Trepel, Martin; Müller, Oliver J; Kleinschmidt, Jürgen A

2012-05-01

Libraries based on the insertion of random peptide ligands into the capsid of adeno-associated virus type 2 (AAV2) have been widely used to improve the efficiency and selectivity of the AAV vector system. However, so far only libraries of 7-mer peptide ligands have been inserted at one well-characterized capsid position. Here, we expanded the combinatorial AAV2 display system to a panel of novel AAV libraries, displaying peptides of 5, 7, 12, 19, or 26 amino acids in length at capsid position 588 or displaying 7-mer peptides at position 453, the most prominently exposed region of the viral capsid. Library selections on two unrelated cell types-human coronary artery endothelial cells and rat cardiomyoblasts-revealed the isolation of cell type-characteristic peptides of different lengths mediating strongly improved target-cell transduction, except for the 26-mer peptide ligands. Characterization of vector selectivity by transduction of nontarget cells and comparative gene-transduction analysis using a panel of 44 human tumor cell lines revealed that insertion of different-length peptides allows targeting of distinct cellular receptors for cell entry with similar efficiency, but with different selectivity. The application of such novel AAV2 libraries broadens the spectrum of targetable receptors by capsid-modified AAV vectors and provides the opportunity to choose the best suited targeting ligand for a certain application from a number of different candidates.

The Case for Graphic Novels

Directory of Open Access Journals (Sweden)

Steven Hoover

2012-04-01

Full Text Available Many libraries and librarians have embraced graphic novels. A number of books, articles, and presentations have focused on the history of the medium and offered advice on building and maintaining collections, but very little attention has been given the question of how integrate graphic novels into a library’s instructional efforts. This paper will explore the characteristics of graphic novels that make them a valuable resource for librarians who focus on research and information literacy instruction, identify skills and competencies that can be taught by the study of graphic novels, and will provide specific examples of how to incorporate graphic novels into instruction.

The Case for Graphic Novels

OpenAIRE

Steven Hoover

2012-01-01

Many libraries and librarians have embraced graphic novels. A number of books, articles, and presentations have focused on the history of the medium and offered advice on building and maintaining collections, but very little attention has been given the question of how integrate graphic novels into a library’s instructional efforts. This paper will explore the characteristics of graphic novels that make them a valuable resource for librarians who focus on research and information literacy i...

Random mutagenesis of BoNT/E Hc nanobody to construct a secondary phage-display library.

Science.gov (United States)

Shahi, B; Mousavi Gargari, S L; Rasooli, I; Rajabi Bazl, M; Hoseinpoor, R

2014-08-01

To construct secondary mutant phage-display library of recombinant single variable domain (VHH) against botulinum neurotoxin E by error-prone PCR. The gene coding for specific VHH derived from the camel immunized with binding domain of botulinum neurotoxin E (BoNT/E) was amplified by error-prone PCR. Several biopanning rounds were used to screen the phage-displaying BoNT/E Hc nanobodies. The final nanobody, SHMR4, with increased affinity recognized BoNT/E toxin with no cross-reactivity with other antigens especially with related BoNT toxins. The constructed nanobody could be a suitable candidate for VHH-based biosensor production to detect the Clostridium botulinum type E. Diagnosis and treatment of botulinum neurotoxins are important. Generation of high-affinity antibodies based on the construction of secondary libraries using affinity maturation step leads to the development of reagents for precise diagnosis and therapy. © 2014 The Society for Applied Microbiology.

Tag, You're It: Enhancing Access to Graphic Novels

Science.gov (United States)

West, Wendy

2013-01-01

Current users of academic libraries are avid readers of graphic novels. These thought-provoking materials are used for leisure reading, in instruction, and for research purposes. Libraries need to take care in providing access to these resources. This study analyzed the cataloging practices and social tagging of a specific list of graphic novel…

Getting Started with Graphic Novels in School Libraries

Science.gov (United States)

Haynes, Elizabeth

2009-01-01

Graphic novels have become increasingly popular with young people over the last few years. At the same time, they have become much more prominent in popular culture in general. One only needs to look at the plethora of summer blockbuster movies based on comic superheroes or the increasing amount of shelf space devoted to graphic novels and manga…

Implementation of the ALEPH detector simulation code using UNIX with on-line graphics display

International Nuclear Information System (INIS)

Corden, M.J.; Georgiopoulos, C.H.; Mermikides, M.E.; Streets, J.

1989-01-01

GALEPH, the detector simulation program of the ALEPH detector was ported to an ETA10 running under ATandT UNIX System 5. The program on the ETA10 can be driven using standard UNIX socket connections between the ETA and a Silicon Graphics Iris-3020 workstation. The simulated data on the ETA are transferred, using the machine independent binary format EPIO, and displayed on the workstation using a locally developed software package for the visualization of the ALEPH detector. The client (Iris-3020) can also pass parameters to the server (ETA10) and thus interactively change the type of events produced using the same socket connection. (orig.)

Introduction to Graphics Programming in Java

DEFF Research Database (Denmark)

Rosendahl, Mads

Writing graphics applications in Java using Swing can be quite a daunting experience which requires understanding of some large libraries, and fairly advanced aspects of Java. In these notes we will show that by using a small subset of the Swing package we can write a write range of graphics...

Display-management system for MFTF

International Nuclear Information System (INIS)

Nelson, D.O.

1981-01-01

The Mirror Fusion Test Facility (MFTF) is controlled by 65 local control microcomputers which are supervised by a local network of nine 32-bit minicomputers. Associated with seven of the nine computers are state-of-the-art graphics devices, each with extensive local processing capability. These devices provide the means for an operator to interact with the control software running on the minicomputers. It is critical that the information the operator views accurately reflects the current state of the experiment. This information is integrated into dynamically changing pictures called displays. The primary organizational component of the display system is the software-addressable segment. The segments created by the display creation software are managed by display managers associated with each graphics device. Each display manager uses sophisticated storage management mechanisms to keep the proper segments resident in the local graphics device storage

Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes.

Science.gov (United States)

Lee, Nam-Kyung; Bidlingmaier, Scott; Su, Yang; Liu, Bin

2018-01-01

Monoclonal antibodies and antibody-derived therapeutics have emerged as a rapidly growing class of biological drugs for the treatment of cancer, autoimmunity, infection, and neurological diseases. To support the development of human antibodies, various display techniques based on antibody gene repertoires have been constructed over the last two decades. In particular, scFv-antibody phage display has been extensively utilized to select lead antibodies against a variety of target antigens. To construct a scFv phage display that enables efficient antibody discovery, and optimization, it is desirable to develop a system that allows modular assembly of highly diverse variable heavy chain and light chain (Vκ and Vλ) repertoires. Here, we describe modular construction of large non-immune human antibody phage-display libraries built on variable gene cassettes from heavy chain and light chain repertoires (Vκ- and Vλ-light can be made into independent cassettes). We describe utility of such libraries in antibody discovery and optimization through chain shuffling.

Librarians and Graphic Design: Preparation, Roles, and Desired Support

Science.gov (United States)

Wakimoto, Diana K.

2015-01-01

Librarians often become de facto graphic designers for their libraries, taking responsibility for designing signage, handouts, brochures, web pages, and many other promotional, instructional, and wayfinding documents. However, the majority of librarians with graphic design responsibilities are not trained as graphic designers. This exploratory…

The graphics-based human interface to the DISYS diagnostic/control guidance system at EBR-2

International Nuclear Information System (INIS)

Edwards, R.M.; Chavez, C.; Kamarthi, S.; Dharap, S.; Lindsay, R.W.; Staffon, J.

1990-01-01

An initial graphics based interface to the real-time DISYS diagnostic system has been developed using the multi-tasking capabilities of the UNIX operating system and X-Windows 11 Xlib graphics library. This system is interfaced to live plant data at the Experimental Breeder Reactor (EBR-2) for the Argon Cooling System of fuel handling operations and the steam plant. The interface includes an intelligent process schematic which highlights problematic components and sensors based on the results of the diagnostic computations. If further explanation of a faulted component is required, the user can call up a display of the diagnostic computations presented in a tree-like diagram. Numerical data on the process schematic and optional diagnostic tree are updated as new real-time data becomes available. The initial X-Windows 11 based interface will be further enhanced using VI Corporation DATAVIEWS graphical data base software. 5 refs., 6 figs

TMACS test procedure TP003: Graphics. Revision 5

International Nuclear Information System (INIS)

Scanlan, P.K.

1994-01-01

The TMACS Software Project Test Procedures translate the project's acceptance criteria into test steps. Software releases are certified when the affected Test Procedures are successfully performed and the customers authorize installation of these changes. This Test Procedure addresses the graphics requirements of the TMACS. The features to be tested are the data display graphics and the graphic elements that provide for operator control and selection of displays

TMACS test procedure TP003: Graphics. Revision 6

International Nuclear Information System (INIS)

Scanlan, P.K.; Washburn, S.

1994-01-01

The TMACS Software Project Test Procedures translate the project's acceptance criteria into test steps. Software releases are certified when the affected Test Procedures are successfully performed and the customers authorize installation of these changes. This Test Procedure addresses the graphics requirements of the TMACS. The features to be tested are the data display graphics and the graphic elements that provide for operator control and selection of displays

A Linux Workstation for High Performance Graphics

Science.gov (United States)

Geist, Robert; Westall, James

2000-01-01

The primary goal of this effort was to provide a low-cost method of obtaining high-performance 3-D graphics using an industry standard library (OpenGL) on PC class computers. Previously, users interested in doing substantial visualization or graphical manipulation were constrained to using specialized, custom hardware most often found in computers from Silicon Graphics (SGI). We provided an alternative to expensive SGI hardware by taking advantage of third-party, 3-D graphics accelerators that have now become available at very affordable prices. To make use of this hardware our goal was to provide a free, redistributable, and fully-compatible OpenGL work-alike library so that existing bodies of code could simply be recompiled. for PC class machines running a free version of Unix. This should allow substantial cost savings while greatly expanding the population of people with access to a serious graphics development and viewing environment. This should offer a means for NASA to provide a spectrum of graphics performance to its scientists, supplying high-end specialized SGI hardware for high-performance visualization while fulfilling the requirements of medium and lower performance applications with generic, off-the-shelf components and still maintaining compatibility between the two.

Selection of diethylstilbestrol-specific single-chain antibodies from a non-immunized mouse ribosome display library.

Directory of Open Access Journals (Sweden)

Yanan Sun

Full Text Available Single chain variable fragments (scFvs against diethylstilbestrol (DES were selected from the splenocytes of non-immunized mice by ribosome display technology. A naive library was constructed and engineered to allow in vitro transcription and translation using an E. coli lysate system. Alternating selection in solution and immobilization in microtiter wells was used to pan mRNA-ribosome-antibody (ARM complexes. After seven rounds of ribosome display, the expression vector pTIG-TRX containing the selected specific scFv DNAs were transformed into Escherichia coli BL21 (DE3 for expression. Twenty-six positive clones were screened and five clones had high antibody affinity and specificity to DES as evidenced by indirect competitive ELISA. Sequence analysis showed that these five DES-specific scFvs had different amino acid sequences, but the CDRs were highly similar. Surface plasmon resonance (SPR analysis was used to determine binding kinetics of one clone (30-1. The measured K(D was 3.79 µM. These results indicate that ribosome display technology can be used to efficiently isolate hapten-specific antibody (Ab fragments from a naive library; this study provides a methodological framework for the development of novel immunoassays for multiple environmental pollutants with low molecular weight detection using recombinant antibodies.

DISPPAK SUBPAK, MS FORTRAN Extended Subroutine Library

International Nuclear Information System (INIS)

Langer, S.

1991-01-01

1 - Description of program or function: DISPPAK is a set of routines for use with Microsoft FORTRAN programs that allows the flexible display of information on the screen of an IBM PC in both text and graphics modes. The text mode routines allow the cursor to be placed at an arbitrary point on the screen and text to be displayed at the cursor location, making it possible to create menus and other structured displays. A routine to set the color of the characters that these routines display is also provided. A set of line drawing routines is included for use with IBM's Color Graphics Adapter or an equivalent board (such as the Enhanced Graphics Adapter in CGA emulation mode). These routines support both pixel coordinates and a user-specified set of real number coordinates. SUBPAK is a function library which allows Microsoft FORTRAN programs to calculate random numbers, issue calls to the operating system, read individual characters from the keyboard, perform Boolean and shift operations, and communicate with the I/O ports of the IBM PC. In addition, peek and poke routines, a routine that returns the address of any variable, and routines that can access the system time and date are included. 2 - Method of solution: For the DISPPAK line drawing routines, the user selects a fraction of the screen to use for plotting, chooses the coordinates that refer to the lower-left and upper-right corners, and decides whether the mapping should be linear or logarithmic. Lines are then drawn between endpoints defined in terms of the user coordinate system. Out-of-range coordinates are forced to the border of the window before the line is drawn. 3 - Restrictions on the complexity of the problem: No support is provided for filled areas or text

Graphics gems V (Macintosh version)

CERN Document Server

Paeth, Alan W

1995-01-01

Graphics Gems V is the newest volume in The Graphics Gems Series. It is intended to provide the graphics community with a set of practical tools for implementing new ideas and techniques, and to offer working solutions to real programming problems. These tools are written by a wide variety of graphics programmers from industry, academia, and research. The books in the series have become essential, time-saving tools for many programmers.Latest collection of graphics tips in The Graphics Gems Series written by the leading programmers in the field.Contains over 50 new gems displaying some of t

'Grafic'. A subroutine for the graphic displays

International Nuclear Information System (INIS)

Yunta Carretero, J.

1977-01-01

The subroutire Grafic allows the drawing of different standard graphics in a pploter Calcomp and avoid the users the preparation of calls to several Plot subroutines, which are necessary for the plotting. The possibilities of this subroutine, user's guide, suggestions about better use and examples, and also the carry out in Fortran language, are described. (author) [es

DIGLIB, Multi Platform Graphics Subroutine Library

International Nuclear Information System (INIS)

Buleson, R.R.

2002-01-01

Description of program or function: DIGLIB is a collection of general graphics subroutines. It was designed to be small, reasonably fast, device-independent, and compatible with DEC-supplied operating systems for VAXes, PDP-11s, and LSI-11s, and the DOS operating system for IBM PCs and IBM-compatible machines. The software is readily usable for casual programmers for two-dimensional plotting

Computer graphics in heat-transfer simulations

International Nuclear Information System (INIS)

Hamlin, G.A. Jr.

1980-01-01

Computer graphics can be very useful in the setup of heat transfer simulations and in the display of the results of such simulations. The potential use of recently available low-cost graphics devices in the setup of such simulations has not been fully exploited. Several types of graphics devices and their potential usefulness are discussed, and some configurations of graphics equipment are presented in the low-, medium-, and high-price ranges

A compact phage display human scFv library for selection of antibodies to a wide variety of antigens

Directory of Open Access Journals (Sweden)

Kristensen Peter

2009-01-01

Full Text Available Abstract Background Phage display technology is a powerful new tool for making antibodies outside the immune system, thus avoiding the use of experimental animals. In the early days, it was postulated that this technique would eventually replace hybridoma technology and animal immunisations. However, since this technology emerged more than 20 years ago, there have only been a handful reports on the construction and application of phage display antibody libraries world-wide. Results Here we report the simplest and highly efficient method for the construction of a highly useful human single chain variable fragment (scFv library. The least number of oligonucleotide primers, electroporations and ligation reactions were used to generate a library of 1.5 × 108 individual clones, without generation of sub-libraries. All possible combinations of heavy and light chains, among all immunoglobulin isotypes, were included by using a mixture of primers and overlapping extension PCR. The key difference from other similar libraries was the highest diversity of variable gene repertoires, which was derived from 140 non-immunized human donors. A wide variety of antigens were successfully used to affinity select specific binders. These included pure recombinant proteins, a hapten and complex antigens such as viral coat proteins, crude snake venom and cancer cell surface antigens. In particular, we were able to use standard bio-panning method to isolate antibody that can bind to soluble Aflatoxin B1, when using BSA-conjugated toxin as a target, as demonstrated by inhibition ELISA. Conclusion These results suggested that by using an optimized protocol and very high repertoire diversity, a compact and efficient phage antibody library can be generated. This advanced method could be adopted by any molecular biology laboratory to generate both naïve or immunized libraries for particular targets as well as for high-throughput applications.

The application of autostereoscopic display in smart home system based on mobile devices

Science.gov (United States)

Zhang, Yongjun; Ling, Zhi

2015-03-01

Smart home is a system to control home devices which are more and more popular in our daily life. Mobile intelligent terminals based on smart homes have been developed, make remote controlling and monitoring possible with smartphones or tablets. On the other hand, 3D stereo display technology developed rapidly in recent years. Therefore, a iPad-based smart home system adopts autostereoscopic display as the control interface is proposed to improve the userfriendliness of using experiences. In consideration of iPad's limited hardware capabilities, we introduced a 3D image synthesizing method based on parallel processing with Graphic Processing Unit (GPU) implemented it with OpenGL ES Application Programming Interface (API) library on IOS platforms for real-time autostereoscopic displaying. Compared to the traditional smart home system, the proposed system applied autostereoscopic display into smart home system's control interface enhanced the reality, user-friendliness and visual comfort of interface.

Simulaser, a graphical laser simulator based on Matlab Simulink

CSIR Research Space (South Africa)

Jacobs, Cobus

2016-07-01

Full Text Available We present a single-element plane-wave laser rate equation model and its implementation as a graphical laser simulation library using Matlab Simulink. Simulink’s graphical interface and vector capabilities provide a unique layer of abstraction...

Interactive computer graphics displays for hierarchical data structures. [Description of THESGRAF, in FORTRAN IV for CDC and IBM computers

Energy Technology Data Exchange (ETDEWEB)

Cahn, D.F.; Murano, C.V.

1980-05-01

An interactive computer graphical display program was developed as an aid to user visualization and manipulation of hierarchically structured data systems such as thesauri. In the present configuration, a thesaurus term and its primary and secondary conceptual neighbors are presented to the user in tree graph form on a CRT; the user then designates, via light pen or keyboard, any of the neighbors as the next term of interest and receives a new display centered on this term. By successive specification of broader, narrower, and related terms, the user can course rapidly through the thesaurus space and refine his search file. At any stage, he deals with a term-centered, conceptually meaningful picture of a localized portion of the thesaurus, and is freed from the artificial difficulties of handling the traditional alphabetized thesaurus. Intentional limitation of the associative range of each display frame, and the use of color, case, and interconnecting vectors to encode relationships among terms, enhance interpretability of the display. Facile movement through the term space, provided by interactive computation, allows the display to remain simple, and is an essential element of the system. 3 figures.

COREMAP: Graphical user interface for displaying reactor core data in an interactive hexagon map

International Nuclear Information System (INIS)

Muscat, F.L.; Derstine, K.L.

1995-01-01

COREMAP is a Graphical User Interface (GUI) designed to assist users read and check reactor core data from multidimensional neutronic simulation models in color and/or as text in an interactive 2D planar grid of hexagonal subassemblies. COREMAP is a complete GEODST/RUNDESC viewing tool which enables the user to access multi data set files (e.g. planes, moments, energy groups ,... ) and display up to two data sets simultaneously, one as color and the other as text. The user (1) controls color scale characteristics such as type (linear or logarithmic) and range limits, (2) controls the text display based upon conditional statements on data spelling, and value. (3) chooses zoom features such as core map size, number of rings and surrounding subassemblies, and (4) specifies the data selection for supplied popup subwindows which display a selection of data currently off-screen for a selected cell, as a list of data and/or as a graph. COREMAP includes a RUNDESC file editing tool which creates ''proposed'' Run-description files by point and click revisions to subassembly assignments in an existing EBRII Run-description file. COREMAP includes a fully automated printing option which creates high quality PostScript color or greyscale images of the core map independent of the monitor used, e.g. color prints can be generated with a session from a color or monochrome monitor. The automated PostScript output is an alternative to the xgrabsc based printing option. COREMAP includes a plotting option which creates graphs related to a selected cell. The user specifies the X and Y coordinates types (planes, moment, group, flux ,... ) and a parameter, P, when displaying several curves for the specified (X, Y) pair COREMAP supports hexagonal geometry reactor core configurations specified by: the GEODST file and binary Standard Interface Files and the RUNDESC ordering

Novel β-lactamase-random peptide fusion libraries for phage display selection of cancer cell-targeting agents suitable for enzyme prodrug therapy

Science.gov (United States)

Shukla, Girja S.; Krag, David N.

2010-01-01

Novel phage-displayed random linear dodecapeptide (X12) and cysteine-constrained decapeptide (CX10C) libraries constructed in fusion to the amino-terminus of P99 β-lactamase molecules were used for identifying β-lactamase-linked cancer cell-specific ligands. The size and quality of both libraries were comparable to the standards of other reported phage display systems. Using the single-round panning method based on phage DNA recovery, we identified severalβ-lactamase fusion peptides that specifically bind to live human breast cancer MDA-MB-361 cells. The β-lactamase fusion to the peptides helped in conducting the enzyme activity-based clone normalization and cell-binding screening in a very time- and cost-efficient manner. The methods were suitable for 96-well readout as well as microscopic imaging. The success of the biopanning was indicated by the presence of ~40% cancer cell-specific clones among recovered phages. One of the binding clones appeared multiple times. The cancer cell-binding fusion peptides also shared several significant motifs. This opens a new way of preparing and selecting phage display libraries. The cancer cell-specific β-lactamase-linked affinity reagents selected from these libraries can be used for any application that requires a reporter for tracking the ligand molecules. Furthermore, these affinity reagents have also a potential for their direct use in the targeted enzyme prodrug therapy of cancer. PMID:19751096

MACKLIB-IV: a library of nuclear response functions generated with the MACK-IV computer program from ENDF/B-IV

International Nuclear Information System (INIS)

Gohar, Y.; Abdou, M.A.

1978-03-01

MACKLIB-IV employs the CTR energy group structure of 171 neutron groups and 36 gamma groups. A retrieval computer program is included with the library to permit collapsing into any other energy group structure. The library is in the new format of the ''MACK-Activity Table'' which uses a fixed position for each specific response function. This permits the user when employing the library with present transport codes to obtain directly the nuclear responses (e.g. the total nuclear heating) summed for all isotopes and integrated over any geometrical volume. The response functions included in the library are neutron kerma factor, gamma kerma factor, gas production and tritium-breeding functions, and all important reaction cross sections. Pertinent information about the library and a graphical display of six response functions for all materials in the library are given

A computer graphics pilot project - Spacecraft mission support with an interactive graphics workstation

Science.gov (United States)

Hagedorn, John; Ehrner, Marie-Jacqueline; Reese, Jodi; Chang, Kan; Tseng, Irene

1986-01-01

The NASA Computer Graphics Pilot Project was undertaken to enhance the quality control, productivity and efficiency of mission support operations at the Goddard Operations Support Computing Facility. The Project evolved into a set of demonstration programs for graphics intensive simulated control room operations, particularly in connection with the complex space missions that began in the 1980s. Complex mission mean more data. Graphic displays are a means to reduce the probabilities of operator errors. Workstations were selected with 1024 x 768 pixel color displays controlled by a custom VLSI chip coupled to an MC68010 chip running UNIX within a shell that permits operations through the medium of mouse-accessed pulldown window menus. The distributed workstations run off a host NAS 8040 computer. Applications of the system for tracking spacecraft orbits and monitoring Shuttle payload handling illustrate the system capabilities, noting the built-in capabilities of shifting the point of view and rotating and zooming in on three-dimensional views of spacecraft.

Influence of Point-of-Sale Tobacco Displays and Graphic Health Warning Signs on Adults: Evidence From a Virtual Store Experimental Study

Science.gov (United States)

Kim, Annice E.; Nonnemaker, James M.; Loomis, Brett R.; Shafer, Paul R.; Shaikh, Asma; Hill, Edward; Holloway, John W.; Farrelly, Matthew C.

2014-01-01

Objectives. We tested the impact of banning tobacco displays and posting graphic health warning signs at the point of sale (POS). Methods. We designed 3 variations of the tobacco product display (open, enclosed [not visible], enclosed with pro-tobacco ads) and 2 variations of the warning sign (present vs absent) with virtual store software. In December 2011 and January 2012, we randomized a national convenience sample of 1216 adult smokers and recent quitters to 1 of 6 store conditions and gave them a shopping task. We tested for the main effects of the enclosed display, the sign, and their interaction on urge to smoke and tobacco purchase attempts. Results. The enclosed display significantly lowered current smokers’ (B = −7.05; 95% confidence interval [CI] = −13.20, −0.91; P influence purchase behavior. Banning them may reduce cues to smoke and unplanned tobacco purchases. PMID:24625149

Graphic Grown Up

Science.gov (United States)

Kim, Ann

2009-01-01

It's no secret that children and YAs are clued in to graphic novels (GNs) and that comics-loving adults are positively giddy that this format is getting the recognition it deserves. Still, there is a whole swath of library card-carrying grown-up readers out there with no idea where to start. Splashy movies such as "300" and "Spider-Man" and their…

Nucleic acid secondary structure prediction and display.

OpenAIRE

Stüber, K

1986-01-01

A set of programs has been developed for the prediction and display of nucleic acid secondary structures. Information from experimental data can be used to restrict or enforce secondary structural elements. The predictions can be displayed either on normal line printers or on graphic devices like plotters or graphic terminals.

Object-oriented graphics programming in C++

CERN Document Server

Stevens, Roger T

2014-01-01

Object-Oriented Graphics Programming in C++ provides programmers with the information needed to produce realistic pictures on a PC monitor screen.The book is comprised of 20 chapters that discuss the aspects of graphics programming in C++. The book starts with a short introduction discussing the purpose of the book. It also includes the basic concepts of programming in C++ and the basic hardware requirement. Subsequent chapters cover related topics in C++ programming such as the various display modes; displaying TGA files, and the vector class. The text also tackles subjects on the processing

Computer graphics aid mission operations. [NASA missions

Science.gov (United States)

Jeletic, James F.

1990-01-01

The application of computer graphics techniques in NASA space missions is reviewed. Telemetric monitoring of the Space Shuttle and its components is discussed, noting the use of computer graphics for real-time visualization problems in the retrieval and repair of the Solar Maximum Mission. The use of the world map display for determining a spacecraft's location above the earth and the problem of verifying the relative position and orientation of spacecraft to celestial bodies are examined. The Flight Dynamics/STS Three-dimensional Monitoring System and the Trajectroy Computations and Orbital Products System world map display are described, emphasizing Space Shuttle applications. Also, consideration is given to the development of monitoring systems such as the Shuttle Payloads Mission Monitoring System and the Attitude Heads-Up Display and the use of the NASA-Goddard Two-dimensional Graphics Monitoring System during Shuttle missions and to support the Hubble Space Telescope.

Immune TB Antibody Phage Display Library as a Tool To Study B Cell Immunity in TB Infections.

Science.gov (United States)

Hamidon, Nurul Hamizah; Suraiya, Siti; Sarmiento, Maria E; Acosta, Armando; Norazmi, Mohd Nor; Lim, Theam Soon

2018-03-01

B cells and in particular antibodies has always played second fiddle to cellular immunity in regard to tuberculosis (TB). However, recent studies has helped position humoral immunity especially antibodies back into the foray in relation to TB immunity. Therefore, the ability to correlate the natural antibody responses of infected individuals toward TB antigens would help strengthen this concept. Phage display is an intriguing approach that can be utilized to study antibody-mediated responses against a particular infection via harvesting the B cell repertoire from infected individuals. The development of disease-specific antibody libraries or immune libraries is useful to better understand antibody-mediated immune responses against specific disease antigens. This study describes the generation of an immune single-chain variable fragment (scFv) library derived from TB-infected individuals. The immune library with an estimated diversity of 10 9 independent clones was then applied for the identification of monoclonal antibodies against Mycobacterium tuberculosis α-crystalline as a model antigen. Biopanning of the library isolated three monoclonal antibodies with unique gene usage. This strengthens the role of antibodies in TB immunity in addition to the role played by cellular immunity. The developed library can be applied against other TB antigens and aid antibody-derived TB immunity studies in the future.

Development of Calcomp compatible interface library 'piflib' on X Window System

International Nuclear Information System (INIS)

Tanabe, Hidenobu; Yokokawa, Mitsuo; Onuma, Yoshio.

1993-05-01

Graphics processing at JAERI mainly has been executed on mainframe computers with Calcomp compatible graphics libraries. With spread of engineering workstations (EWS), it is important that those enormous graphics softwares be able to be carried out on EWS. The Calcomp compatible interface library 'piflib' has been developed on the X Window System, which is the most popular window environments on EWS. In this report, specifications of the library 'piflib' and its usages are presented. The cooperative processing with mainframe computers is also described. (author)

X based interactive computer graphics applications for aerodynamic design and education

Science.gov (United States)

Benson, Thomas J.; Higgs, C. Fred, III

1995-01-01

Six computer applications packages have been developed to solve a variety of aerodynamic problems in an interactive environment on a single workstation. The packages perform classical one dimensional analysis under the control of a graphical user interface and can be used for preliminary design or educational purposes. The programs were originally developed on a Silicon Graphics workstation and used the GL version of the FORMS library as the graphical user interface. These programs have recently been converted to the XFORMS library of X based graphics widgets and have been tested on SGI, IBM, Sun, HP and PC-Lunix computers. The paper will show results from the new VU-DUCT program as a prime example. VU-DUCT has been developed as an educational package for the study of subsonic open and closed loop wind tunnels.

User's manual for the two-dimensional transputer graphics toolkit

Science.gov (United States)

Ellis, Graham K.

1988-01-01

The user manual for the 2-D graphics toolkit for a transputer based parallel processor is presented. The toolkit consists of a package of 2-D display routines that can be used for the simulation visualizations. It supports multiple windows, double buffered screens for animations, and simple graphics transformations such as translation, rotation, and scaling. The display routines are written in occam to take advantage of the multiprocessing features available on transputers. The package is designed to run on a transputer separate from the graphics board.

OAP- OFFICE AUTOMATION PILOT GRAPHICS DATABASE SYSTEM

Science.gov (United States)

Ackerson, T.

1994-01-01

The Office Automation Pilot (OAP) Graphics Database system offers the IBM PC user assistance in producing a wide variety of graphs and charts. OAP uses a convenient database system, called a chartbase, for creating and maintaining data associated with the charts, and twelve different graphics packages are available to the OAP user. Each of the graphics capabilities is accessed in a similar manner. The user chooses creation, revision, or chartbase/slide show maintenance options from an initial menu. The user may then enter or modify data displayed on a graphic chart. The cursor moves through the chart in a "circular" fashion to facilitate data entries and changes. Various "help" functions and on-screen instructions are available to aid the user. The user data is used to generate the graphics portion of the chart. Completed charts may be displayed in monotone or color, printed, plotted, or stored in the chartbase on the IBM PC. Once completed, the charts may be put in a vector format and plotted for color viewgraphs. The twelve graphics capabilities are divided into three groups: Forms, Structured Charts, and Block Diagrams. There are eight Forms available: 1) Bar/Line Charts, 2) Pie Charts, 3) Milestone Charts, 4) Resources Charts, 5) Earned Value Analysis Charts, 6) Progress/Effort Charts, 7) Travel/Training Charts, and 8) Trend Analysis Charts. There are three Structured Charts available: 1) Bullet Charts, 2) Organization Charts, and 3) Work Breakdown Structure (WBS) Charts. The Block Diagram available is an N x N Chart. Each graphics capability supports a chartbase. The OAP graphics database system provides the IBM PC user with an effective means of managing data which is best interpreted as a graphic display. The OAP graphics database system is written in IBM PASCAL 2.0 and assembler for interactive execution on an IBM PC or XT with at least 384K of memory, and a color graphics adapter and monitor. Printed charts require an Epson, IBM, OKIDATA, or HP Laser

Engineering graphics data entry for space station data base

Science.gov (United States)

Lacovara, R. C.

1986-01-01

The entry of graphical engineering data into the Space Station Data Base was examined. Discussed were: representation of graphics objects; representation of connectivity data; graphics capture hardware; graphics display hardware; site-wide distribution of graphics, and consolidation of tools and hardware. A fundamental assumption was that existing equipment such as IBM based graphics capture software and VAX networked facilities would be exploited. Defensible conclusions reached after study and simulations of use of these systems at the engineering level are: (1) existing IBM based graphics capture software is an adequate and economical means of entry of schematic and block diagram data for present and anticipated electronic systems for Space Station; (2) connectivity data from the aforementioned system may be incorporated into the envisioned Space Station Data Base with modest effort; (3) graphics and connectivity data captured on the IBM based system may be exported to the VAX network in a simple and direct fashion; (4) graphics data may be displayed site-wide on VT-125 terminals and lookalikes; (5) graphics hard-copy may be produced site-wide on various dot-matrix printers; and (6) the system may provide integrated engineering services at both the engineering and engineering management level.

Fireworks: A physics event display for CMS

International Nuclear Information System (INIS)

Kovalskyi, D.; Tadel, M.; Mrak-Tadel, A.; Bellenot, B.; Kuznetsov, V.; Jones, C.D.; Bauerdick, L.; Case, M.; Mulmenstadt, J.; Yagil, A.

2010-01-01

Fireworks is a CMS event display which is specialized for the physics studies case. This specialization allows us to use a stylized rather than 3D-accurate representation when appropriate. Data handling is greatly simplified by using only reconstructed information and ideal geometry. Fireworks provides an easy-to-use interface which allows a physicist to concentrate only on the data in which he is interested. Data is presented via graphical and textual views. Fireworks is built using the Eve subsystem of the CERN ROOT project and CMS's FWLite project. The FWLite project was part of CMS's recent code redesign which separates data classes into libraries separate from algorithms producing the data and uses ROOT directly for C++ object storage, thereby allowing the data classes to be used directly in ROOT.

Fireworks A Physics Event Display for CMS

CERN Document Server

Kovalskyi, D; Mrak-Tadel, A; Bellenot, B; Kuznetsov, V; Jones, C D; Bauerdick, L; Case, M; Mülmenstädt, J; Yagil, A

2010-01-01

Fireworks is a CMS event display which is specialized for the physics studies case. This specialization allows us to use a stylized rather than 3D-accurate representation when appropriate. Data handling is greatly simplified by using only reconstructed information and ideal geometry. Fireworks provides an easy-to-use interface which allows a physicist to concentrate only on the data in which he is interested. Data is presented via graphical and textual views. Fireworks is built using the Eve subsystem of the CERN ROOT project and CMS's FWLite project. The FWLite project was part of CMS's recent code redesign which separates data classes into libraries separate from algorithms producing the data and uses ROOT directly for C++ object storage, thereby allowing the data classes to be used directly in ROOT.

Human antibody fragments specific for the epidermal growth factor receptor selected from large non-immunised phage display libraries.

Science.gov (United States)

Souriau, Christelle; Rothacker, Julie; Hoogenboom, Hennie R; Nice, Edouard

2004-09-01

Antibodies to EGFR have been shown to display anti-tumour effects mediated in part by inhibition of cellular proliferation and angiogenesis, and by enhancement of apoptosis. Humanised antibodies are preferred for clinical use to reduce complications with HAMA and HAHA responses frequently seen with murine and chimaeric antibodies. We have used depletion and subtractive selection strategies on cells expressing the EGFR to sample two large antibody fragment phage display libraries for the presence of human antibodies which are specific for the EGFR. Four Fab fragments and six scFv fragments were identified, with affinities of up to 2.2nM as determined by BIAcore analysis using global fitting of the binding curves to obtain the individual rate constants (ka and kd). This overall approach offers a generic screening method for the identification of growth factor specific antibodies and antibody fragments from large expression libraries and has potential for the rapid development of new therapeutic and diagnostic reagents.

Advanced diagnostic graphics

International Nuclear Information System (INIS)

Bray, M.A.; Petersen, R.J.; Clark, M.T.; Gertman, D.I.

1981-01-01

This paper reports US NRC-sponsored research at the Idaho National Engineering Laboratory (INEL) involving evaluation of computer-based diagnostic graphics. The specific targets of current evaluations are multivariate data display formats which may be used in Safety Parameter Display Systems (SPDS) being developed for nuclear power plant control rooms. The purpose of the work is to provide a basis for NRC action in regulating licensee SPDSs or later computer/cathode ray tube (CRT) applications in nuclear control rooms

VAX Professional Workstation goes graphic

International Nuclear Information System (INIS)

Downward, J.G.

1984-01-01

The VAX Professional Workstation (VPW) is a collection of programs and procedures designed to provide an integrated work-station environment for the staff at KMS Fusion's research laboratories. During the past year numerous capabilities have been added to VPW, including support for VT125/VT240/4014 graphic workstations, editing windows, and additional desk utilities. Graphics workstation support allows users to create, edit, and modify graph data files, enter the data via a graphic tablet, create simple plots with DATATRIEVE or DECgraph on ReGIS terminals, or elaborate plots with TEKGRAPH on ReGIS or Tektronix terminals. Users may assign display error bars to the data and interactively plot it in a variety of ways. Users also can create and display viewgraphs. Hard copy output for a large network of office terminals is obtained by multiplexing each terminal's video output into a recently developed video multiplexer front ending a single channel video hard copy unit

Computer Graphics Instruction in VizClass

Science.gov (United States)

Grimes, Douglas; Warschauer, Mark; Hutchinson, Tara; Kuester, Falko

2005-01-01

"VizClass" is a university classroom environment designed to offer students in computer graphics and engineering courses up-to-date visualization technologies. Three digital whiteboards and a three-dimensional stereoscopic display provide complementary display surfaces. Input devices include touchscreens on the digital whiteboards, remote…

Sequence walkers: a graphical method to display how binding proteins interact with DNA or RNA sequences | Center for Cancer Research

Science.gov (United States)

A graphical method is presented for displaying how binding proteins and other macromolecules interact with individual bases of nucleotide sequences. Characters representing the sequence are either oriented normally and placed above a line indicating favorable contact, or upside-down and placed below the line indicating unfavorable contact. The positive or negative height of each letter shows the contribution of that base to the average sequence conservation of the binding site, as represented by a sequence logo.

Free, cross-platform gRaphical software

DEFF Research Database (Denmark)

Dethlefsen, Claus

2006-01-01

-recursive graphical models, and models defined using the BUGS language. Today, there exists a wide range of packages to support the analysis of data using graphical models. Here, we focus on Open Source software, making it possible to extend the functionality by integrating these packages into more general tools. We...... will attempt to give an overview of the available Open Source software, with focus on the gR project. This project was launched in 2002 to make facilities in R for graphical modelling. Several R packages have been developed within the gR project both for display and analysis of graphical models...

The influence of graphic format on breast cancer risk communication.

Science.gov (United States)

Schapira, Marilyn M; Nattinger, Ann B; McAuliffe, Timothy L

2006-09-01

Graphic displays can enhance quantitative risk communication. However, empiric data regarding the effect of graphic format on risk perception is lacking. We evaluate the effect of graphic format elements on perceptions of risk magnitude and perceived truth of data. Preferences for format also were assessed. Participants (254 female primary care patients) viewed a series of hypothetical risk communications regarding the lifetime risk of breast cancer. Identical numeric risk information was presented using different graphic formats. Risk was perceived to be of lower magnitude when communicated with a bar graph as compared with a pictorial display (p graphic format used to convey quantitative risk information effects key domains of risk perception. One must be cognizant of these effects when designing risk communication strategies.

Identification of antigenic regions on VP2 of African horsesickness virus serotype 3 by using phage-displayed epitope libraries.

Science.gov (United States)

Bentley, L; Fehrsen, J; Jordaan, F; Huismans, H; du Plessis, D H

2000-04-01

VP2 is an outer capsid protein of African horsesickness virus (AHSV) and is recognized by serotype-discriminatory neutralizing antibodies. With the objective of locating its antigenic regions, a filamentous phage library was constructed that displayed peptides derived from the fragmentation of a cDNA copy of the gene encoding VP2. Peptides ranging in size from approximately 30 to 100 amino acids were fused with pIII, the attachment protein of the display vector, fUSE2. To ensure maximum diversity, the final library consisted of three sub-libraries. The first utilized enzymatically fragmented DNA encoding only the VP2 gene, the second included plasmid sequences, while the third included a PCR step designed to allow different peptide-encoding sequences to recombine before ligation into the vector. The resulting composite library was subjected to immunoaffinity selection with AHSV-specific polyclonal chicken IgY, polyclonal horse immunoglobulins and a monoclonal antibody (MAb) known to neutralize AHSV. Antigenic peptides were located by sequencing the DNA of phages bound by the antibodies. Most antigenic determinants capable of being mapped by this method were located in the N-terminal half of VP2. Important binding areas were mapped with high resolution by identifying the minimum overlapping areas of the selected peptides. The MAb was also used to screen a random 17-mer epitope library. Sequences that may be part of a discontinuous neutralization epitope were identified. The amino acid sequences of the antigenic regions on VP2 of serotype 3 were compared with corresponding regions on three other serotypes, revealing regions with the potential to discriminate AHSV serotypes serologically.

Understanding Graphics on a Scalable Latching Assistive Haptic Display Using a Shape Memory Polymer Membrane.

Science.gov (United States)

Besse, Nadine; Rosset, Samuel; Zarate, Juan Jose; Ferrari, Elisabetta; Brayda, Luca; Shea, Herbert

2018-01-01

We present a fully latching and scalable 4 × 4 haptic display with 4 mm pitch, 5 s refresh time, 400 mN holding force, and 650 μm displacement per taxel. The display serves to convey dynamic graphical information to blind and visually impaired users. Combining significant holding force with high taxel density and large amplitude motion in a very compact overall form factor was made possible by exploiting the reversible, fast, hundred-fold change in the stiffness of a thin shape memory polymer (SMP) membrane when heated above its glass transition temperature. Local heating is produced using an addressable array of 3 mm in diameter stretchable microheaters patterned on the SMP. Each taxel is selectively and independently actuated by synchronizing the local Joule heating with a single pressure supply. Switching off the heating locks each taxel into its position (up or down), enabling holding any array configuration with zero power consumption. A 3D-printed pin array is mounted over the SMP membrane, providing the user with a smooth and room temperature array of movable pins to explore by touch. Perception tests were carried out with 24 blind users resulting in 70 percent correct pattern recognition over a 12-word tactile dictionary.

Ultrascale collaborative visualization using a display-rich global cyberinfrastructure.

Science.gov (United States)

Jeong, Byungil; Leigh, Jason; Johnson, Andrew; Renambot, Luc; Brown, Maxine; Jagodic, Ratko; Nam, Sungwon; Hur, Hyejung

2010-01-01

The scalable adaptive graphics environment (SAGE) is high-performance graphics middleware for ultrascale collaborative visualization using a display-rich global cyberinfrastructure. Dozens of sites worldwide use this cyberinfrastructure middleware, which connects high-performance-computing resources over high-speed networks to distributed ultraresolution displays.

Embedded 3D Graphics Core for FPGA-based System-on-Chip Applications

DEFF Research Database (Denmark)

Holten-Lund, Hans Erik

2005-01-01

This paper presents a 3D graphics accelerator core for an FPGA based system, and illustrates how to build a System-on-Chip containing a Xilinx MicroBlaze soft-core CPU and our 3D graphics accelerator core. The system is capable of running uClinux and hardware accelerated 3D graphics applications......, and the video display which periodically reads from memory to display the final rendered graphics. The graphics core uses internal scratch-pad memory to reduce its external bandwidth requirement, this is achieved by implementing a tile-based rendering algorithm. Reduced external bandwidth means that the power...

Development of graphic display program of reactor operating parameters for emergency exercise at nuclear power plants

International Nuclear Information System (INIS)

Okuda, Yasunori; Yoshida, Yoshitaka; Gotou, Kazuko

2001-01-01

A scenario of nuclear emergency exercise based on the result of accident progress analysis is expected to ensure effective training. Thereupon a new graphic display program for reactor operating parameters has been developed to present real-time of plant process values (parameters), released radioactivities from the plant, and dose rate data around the site calculated by using the accident analysis code MAAP4 and other codes. This system has a trend graph screen displaying reactor operating parameters, an environmental dose rate summary screen indicating dose rate distribution around the site on the map, and a plant parameters summary screen showing important plant parameters on a simplified plant system diagram. One screen can be switched to another any time. It also has a jump-function easily accessing any stage during the exercise scenario in accordance with progress of the exercise. As a result of the application of this system to a real nuclear emergency exercise, it has been verified that this system is quite useful for confirming the parameters when the nuclear emergency exercise starts and the licensee reports the plant conditions to related bodied. (author)

Development of graphic display program of reactor operating parameters for emergency exercise at nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

Okuda, Yasunori; Yoshida, Yoshitaka [Institute of Nuclear Safety System Inc., Mihama, Fukui (Japan); Gotou, Kazuko [Kansai Electric Power Co., Inc., Osaka (Japan)

2001-09-01

A scenario of nuclear emergency exercise based on the result of accident progress analysis is expected to ensure effective training. Thereupon a new graphic display program for reactor operating parameters has been developed to present real-time of plant process values (parameters), released radioactivities from the plant, and dose rate data around the site calculated by using the accident analysis code MAAP4 and other codes. This system has a trend graph screen displaying reactor operating parameters, an environmental dose rate summary screen indicating dose rate distribution around the site on the map, and a plant parameters summary screen showing important plant parameters on a simplified plant system diagram. One screen can be switched to another any time. It also has a jump-function easily accessing any stage during the exercise scenario in accordance with progress of the exercise. As a result of the application of this system to a real nuclear emergency exercise, it has been verified that this system is quite useful for confirming the parameters when the nuclear emergency exercise starts and the licensee reports the plant conditions to related bodied. (author)

Influence of point-of-sale tobacco displays and graphic health warning signs on adults: evidence from a virtual store experimental study.

Science.gov (United States)

Kim, Annice E; Nonnemaker, James M; Loomis, Brett R; Shafer, Paul R; Shaikh, Asma; Hill, Edward; Holloway, John W; Farrelly, Matthew C

2014-05-01

We tested the impact of banning tobacco displays and posting graphic health warning signs at the point of sale (POS). We designed 3 variations of the tobacco product display (open, enclosed [not visible], enclosed with pro-tobacco ads) and 2 variations of the warning sign (present vs absent) with virtual store software. In December 2011 and January 2012, we randomized a national convenience sample of 1216 adult smokers and recent quitters to 1 of 6 store conditions and gave them a shopping task. We tested for the main effects of the enclosed display, the sign, and their interaction on urge to smoke and tobacco purchase attempts. The enclosed display significantly lowered current smokers' (B = -7.05; 95% confidence interval [CI] = -13.20, -0.91; P < .05) and recent quitters' (Β = -6.00, 95% CI = -11.00, -1.00; P < .01) urge to smoke and current smokers' purchase attempts (adjusted odds ratio = 0.06; 95% CI = 0.03, 0.11; P < .01). The warning sign had no significant main effect on study outcomes or interaction with enclosed display. These data show that POS tobacco displays influence purchase behavior. Banning them may reduce cues to smoke and unplanned tobacco purchases.

Scientific and Graphic Design Foundations for C2

Science.gov (United States)

2007-06-01

the elements in the composition. This section presents a summary of the concepts in graphic design layout, typography , color, and data graphics ...document for ease of use 4 Graphic Design • Layout – Literally the aesthetic of the display design • Typography – Serif versus san serif – Font sizes...12th ICCRTS “Adapting C2 to the 21st Century” Title: Scientific and graphic design foundations for C2 Topics: C2 Concepts, Theory and

DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries.

Science.gov (United States)

Franzini, Raphael M; Neri, Dario; Scheuermann, Jörg

2014-04-15

DNA-encoded chemical libraries (DECLs) represent a promising tool in drug discovery. DECL technology allows the synthesis and screening of chemical libraries of unprecedented size at moderate costs. In analogy to phage-display technology, where large antibody libraries are displayed on the surface of filamentous phage and are genetically encoded in the phage genome, DECLs feature the display of individual small organic chemical moieties on DNA fragments serving as amplifiable identification barcodes. The DNA-tag facilitates the synthesis and allows the simultaneous screening of very large sets of compounds (up to billions of molecules), because the hit compounds can easily be identified and quantified by PCR-amplification of the DNA-barcode followed by high-throughput DNA sequencing. Several approaches have been used to generate DECLs, differing both in the methods used for library encoding and for the combinatorial assembly of chemical moieties. For example, DECLs can be used for fragment-based drug discovery, displaying a single molecule on DNA or two chemical moieties at the extremities of complementary DNA strands. DECLs can vary substantially in the chemical structures and the library size. While ultralarge libraries containing billions of compounds have been reported containing four or more sets of building blocks, also smaller libraries have been shown to be efficient for ligand discovery. In general, it has been found that the overall library size is a poor predictor for library performance and that the number and diversity of the building blocks are rather important indicators. Smaller libraries consisting of two to three sets of building blocks better fulfill the criteria of drug-likeness and often have higher quality. In this Account, we present advances in the DECL field from proof-of-principle studies to practical applications for drug discovery, both in industry and in academia. DECL technology can yield specific binders to a variety of target

Blocking peptides against HBV: PreS1 protein selected from a phage display library

International Nuclear Information System (INIS)

Wang, Wei; Liu, Yang; Zu, Xiangyang; Jin, Rui; Xiao, Gengfu

2011-01-01

Highlights: → Successfully selected specific PreS1-interacting peptides by using phage displayed library. → Alignment of the positive phage clones revealed a consensus PreS1 binding motif. → A highly enriched peptide named P7 had a strong binding ability for PreS1. → P7 could block PreS1 attachment. -- Abstract: The PreS1 protein is present on the outermost part of the hepatitis B virus (HBV) surface and has been shown to have a pivotal function in viral infectivity and assembly. The development of reagents with high affinity and specificity for PreS1 is of great significance for early diagnosis and treatment of HBV infection. A phage display library of dodecapeptide was screened for interactions with purified PreS1 protein. Alignment of the positive phage clones revealed a putative consensus PreS1 binding motif of HX n HX m HP/R. Moreover, a peptide named P7 (KHMHWHPPALNT) was highly enriched and occurred with a surprisingly high frequency of 72%. A thermodynamic study revealed that P7 has a higher binding affinity to PreS1 than the other peptides. Furthermore, P7 was able to abrogate the binding of HBV virions to the PreS1 antibody, suggesting that P7 covers key functional sites on the native PreS1 protein. This newly isolated peptide may, therefore, be a new therapeutic candidate for the treatment of HBV. The consensus motif could be modified to deliver imaging, diagnostic, and therapeutic agents to tissues affected by HBV.

Blocking peptides against HBV: PreS1 protein selected from a phage display library

Energy Technology Data Exchange (ETDEWEB)

Wang, Wei; Liu, Yang; Zu, Xiangyang; Jin, Rui [State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071 (China); Xiao, Gengfu, E-mail: xiaogf@wh.iov.cn [State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071 (China)

2011-09-09

Highlights: {yields} Successfully selected specific PreS1-interacting peptides by using phage displayed library. {yields} Alignment of the positive phage clones revealed a consensus PreS1 binding motif. {yields} A highly enriched peptide named P7 had a strong binding ability for PreS1. {yields} P7 could block PreS1 attachment. -- Abstract: The PreS1 protein is present on the outermost part of the hepatitis B virus (HBV) surface and has been shown to have a pivotal function in viral infectivity and assembly. The development of reagents with high affinity and specificity for PreS1 is of great significance for early diagnosis and treatment of HBV infection. A phage display library of dodecapeptide was screened for interactions with purified PreS1 protein. Alignment of the positive phage clones revealed a putative consensus PreS1 binding motif of HX{sub n}HX{sub m}HP/R. Moreover, a peptide named P7 (KHMHWHPPALNT) was highly enriched and occurred with a surprisingly high frequency of 72%. A thermodynamic study revealed that P7 has a higher binding affinity to PreS1 than the other peptides. Furthermore, P7 was able to abrogate the binding of HBV virions to the PreS1 antibody, suggesting that P7 covers key functional sites on the native PreS1 protein. This newly isolated peptide may, therefore, be a new therapeutic candidate for the treatment of HBV. The consensus motif could be modified to deliver imaging, diagnostic, and therapeutic agents to tissues affected by HBV.

On-line data display

Science.gov (United States)

Lang, Sherman Y. T.; Brooks, Martin; Gauthier, Marc; Wein, Marceli

1993-05-01

A data display system for embedded realtime systems has been developed for use as an operator's user interface and debugging tool. The motivation for development of the On-Line Data Display (ODD) have come from several sources. In particular the design reflects the needs of researchers developing an experimental mobile robot within our laboratory. A proliferation of specialized user interfaces revealed a need for a flexible communications and graphical data display system. At the same time the system had to be readily extensible for arbitrary graphical display formats which would be required for data visualization needs of the researchers. The system defines a communication protocol transmitting 'datagrams' between tasks executing on the realtime system and virtual devices displaying the data in a meaningful way on a graphical workstation. The communication protocol multiplexes logical channels on a single data stream. The current implementation consists of a server for the Harmony realtime operating system and an application written for the Macintosh computer. Flexibility requirements resulted in a highly modular server design, and a layered modular object- oriented design for the Macintosh part of the system. Users assign data types to specific channels at run time. Then devices are instantiated by the user and connected to channels to receive datagrams. The current suite of device types do not provide enough functionality for most users' specialized needs. Instead the system design allows the creation of new device types with modest programming effort. The protocol, design and use of the system are discussed.

Computer communications and graphics for clinical radiology

International Nuclear Information System (INIS)

Rhodes, M.L.; Azzawi, Y.; Tivattanasuk, E.S.; Pang, A.T.; Ly, K.; Panicker, H.

1985-01-01

Computer graphics has many forms. When applied in medicine, it can range from simple two dimensional charts and graphs to rendering of three-dimensional scenes. Computer graphic displays of molecular or large anatomic structures have been used to great advantage by numerous medical researchers. In addition, graphic presentations can be dynamic where displays are controlled by physician-user commands, or the presentations can be static, where views are recorded in discrete frames for later distribution or permanent archival. In medicine both interactive and static forms of computer graphics have their proper place in the effective delivery of health care. Computer graphics, however, changes constantly in the area of software techniques, hardware improvements and its clinical application. What may be medically appropriate today in the use of computer graphics can soon become inadequate and well behind the new advances that so quickly follow. In this paper the key feature of computer communication is discussed that aids in the clinical utility of computer graphics in medicine. It is distribution. Distribution in terms of instantaneous computer graphic software updates and more importantly, distribution of meaningful three-dimensional presentations to referring physicians. Physicians who, working in their private offices, have no routine access to medical work stations. In this environment three dimensional presentations of anatomy are static in nature, but must deliver realistic views of critical structures. This paper outlines how computer communication provides the essential ingredient to the provision of this service. As an illustration, the electronic distribution of software to generate three dimensional views of complex anatomoic structures is discussed. Sample views are included

Automated graphic image generation system for effective representation of infectious disease surveillance data.

Science.gov (United States)

Inoue, Masashi; Hasegawa, Shinsaku; Suyama, Akihiko; Meshitsuka, Shunsuke

2003-11-01

Infectious disease surveillance schemes have been established to detect infectious disease outbreak in the early stages, to identify the causative viral strains, and to rapidly assess related morbidity and mortality. To make a scheme function well, two things are required. Firstly, it must have sufficient sensitivity and be timely to guarantee as short a delay as possible from collection to redistribution of information. Secondly, it must provide a good representation of the results of the surveillance. To do this, we have developed a database system that can redistribute the information via the Internet. The feature of this system is to automatically generate the graphic images based on the numerical data stored in the database by using Hypertext Preprocessor (PHP) script and Graphics Drawing (GD) library. It dynamically displays the information as a map or bar chart as well as a numerical impression according to the real time demand of the users. This system will be a useful tool for medical personnel and researchers working on infectious disease problems and will save significant time in the redistribution of information.

Influence of colour on acquisition and generalisation of graphic symbols.

Science.gov (United States)

Hetzroni, O E; Ne'eman, A

2013-07-01

Children with autism may benefit from using graphic symbols for their communication, language and literacy development. The purpose of this study was to investigate the influence of colour versus grey-scale displays on the identification of graphic symbols using a computer-based intervention. An alternating treatment design was employed to examine the learning and generalisation of 58 colour and grey-scale symbols by four preschool children with autism. The graphic symbols were taught via a meaning-based intervention using stories and educational games. Results demonstrate that all of the children were able to learn and maintain symbol identification over time for both symbol displays with no apparent differences. Differences were apparent for two of the children who exhibited better generalisation when learning grey-scale symbols first. The other two showed no noticeable difference, between displays when generalising from one display to the other. Implications and further research are discussed. © 2012 The Authors. Journal of Intellectual Disability Research © 2012 John Wiley & Sons Ltd, MENCAP & IASSID.

Merchandising Your Library.

Science.gov (United States)

Sivulich, Kenneth G.

1989-01-01

Discusses library circulation figures as a reflection of the success of library services and describes merchandising techniques that have produced a 137 percent circulation increase at Queens Borough Public Library over the past seven years. Merchandising techniques such as minibranches, displays, signage, dumps, and modified shelving are…

Printer Graphics Package

Science.gov (United States)

Blanchard, D. C.

1986-01-01

Printer Graphics Package (PGP) is tool for making two-dimensional symbolic plots on line printer. PGP created to support development of Heads-Up Display (HUD) simulation. Standard symbols defined with HUD in mind. Available symbols include circle, triangle, quadrangle, window, line, numbers, and text. Additional symbols easily added or built up from available symbols.

Disjoint forms in graphical user interfaces

NARCIS (Netherlands)

Evers, S.; Achten, P.M.; Plasmeijer, M.J.; Loidl, H.W.

Forms are parts of a graphical user interface (GUI) that show a set of values and allow the user to update them. The declarative form construction library FunctionalForms is extended with disjoint form combinators to capture some common patterns in which the form structure expresses a choice. We

Graphics based PC analysis of alpha spectra

International Nuclear Information System (INIS)

Chapman, T.C.

1991-01-01

New personal computer (PC) software performs interactive analysis of alpha spectra using EGA graphics. Spectra are collected with a commercial MCA board and analyzed using the software described here. The operator is required to approve each peak integration area before analysis proceeds. Sample analysis can use detector efficiencies or spike yields or both. Background corrections are made and upper limit values are calculated when specified. Nuclide identification uses a library of up to 64 nuclides with up to 8 alpha lines for each nuclide. Any one of 32 subset libraries can be used in an analysis. Analysis time is short and is limited by interaction with the operator, not by calculation time. Utilities include nuclide library editing, library subset editing, energy calibration, efficiency calibration, and background update

Network Distributed Data Acquisition, Storage, and Graphical Live Display Software for a Laser Ion Source at CERN

CERN Document Server

Rossel, Ralf Erik; Rothe, Sebastian

2014-01-01

This project documentation outlines the requirements and implementation details for the measurement data recording software currently in development for the Resonance Ionisation Laser Ion Source (RILIS) at CERN. The software is capable of acquiring data from multiple laser parameter monitoring devices and associating the gathered values to represent qualitative and quantitative measurements. The measurement data is displayed graphically within the program and recorded to files for later analysis. The main application of the software is the acquisition coordination and recording of measurement data during spectroscopy experiments performed by RILIS and collaborating experiments. This document describes the design concept and detailed program implementation status at the end of July 2014 and provides an outlook to future developments in RILIS spectroscopy data acquisition.

Real-time graphics for the Space Station Freedom cupola, developed in the Systems Engineering Simulator

Science.gov (United States)

Red, Michael T.; Hess, Philip W.

1989-01-01

Among the Lyndon B. Johnson Space Center's responsibilities for Space Station Freedom is the cupola. Attached to the resource node, the cupola is a windowed structure that will serve as the space station's secondary control center. From the cupola, operations involving the mobile service center and orbital maneuvering vehicle will be conducted. The Systems Engineering Simulator (SES), located in building 16, activated a real-time man-in-the-loop cupola simulator in November 1987. The SES cupola is an engineering tool with the flexibility to evolve in both hardware and software as the final cupola design matures. Two workstations are simulated with closed-circuit television monitors, rotational and translational hand controllers, programmable display pushbuttons, and graphics display with trackball and keyboard. The displays and controls of the SES cupola are driven by a Silicon Graphics Integrated Raster Imaging System (IRIS) 4D/70 GT computer. Through the use of an interactive display builder program, SES, cupola display pages consisting of two dimensional and three dimensional graphics are constructed. These display pages interact with the SES via the IRIS real-time graphics interface. The focus is on the real-time graphics interface applications software developed on the IRIS.

Achieving graphical excellence: suggestions and methods for creating high-quality visual displays of experimental data.

Science.gov (United States)

Schriger, D L; Cooper, R J

2001-01-01

Graphics are an important means of communicating experimental data and results. There is evidence, however, that many of the graphics printed in scientific journals contain errors, redundancies, and lack clarity. Perhaps more important, many graphics fail to portray data at an appropriate level of detail, presenting summary statistics rather than underlying distributions. We seek to aid investigators in the production of high-quality graphics that do their investigations justice by providing the reader with optimum access to the relevant aspects of the data. The depiction of by-subject data, the signification of pairing when present, and the use of symbolic dimensionality (graphing different symbols to identify relevant subgroups) and small multiples (the presentation of an array of similar graphics each depicting one group of subjects) to portray stratification are stressed. Step-by-step instructions for the construction of high-quality graphics are offered. We hope that authors will incorporate these suggestions when developing graphics to accompany their manuscripts and that this process will lead to improvements in the graphical literacy of scientific journals. We also hope that journal editors will keep these principles in mind when refereeing manuscripts submitted for peer review.

pedigreejs: a web-based graphical pedigree editor.

Science.gov (United States)

Carver, Tim; Cunningham, Alex P; Babb de Villiers, Chantal; Lee, Andrew; Hartley, Simon; Tischkowitz, Marc; Walter, Fiona M; Easton, Douglas F; Antoniou, Antonis C

2018-03-15

The collection, management and visualization of clinical pedigree (family history) data is a core activity in clinical genetics centres. However, clinical pedigree datasets can be difficult to manage, as they are time consuming to capture, and can be difficult to build, manipulate and visualize graphically. Several standalone graphical pedigree editors and drawing applications exist but there are no freely available lightweight graphical pedigree editors that can be easily configured and incorporated into web applications. We developed 'pedigreejs', an interactive graphical pedigree editor written in JavaScript, which uses standard pedigree nomenclature. Pedigreejs provides an easily configurable, extensible and lightweight pedigree editor. It makes use of an open-source Javascript library to define a hierarchical layout and to produce images in scalable vector graphics (SVG) format that can be viewed and edited in web browsers. The software is freely available under GPL licence (https://ccge-boadicea.github.io/pedigreejs/). tjc29@cam.ac.uk. Supplementary data are available at Bioinformatics online.

Basic Graphical Data Management System (BAGDAMS version 1.0)

International Nuclear Information System (INIS)

Weindorf, J.W.

1979-06-01

BAGDAMS (BAsic Graphical DAta Management System) is a set of FORTRAN callable subroutines which provides mass storage data structuring and manipulation capabilities. Although primarily designed to facilitate the handling of graphical data files (files containing information to be displayed upon graphical hardware devices), BAGDAMS can also be used in many other applications requiring complex mass storage resident data structures. (author)

Building probabilistic graphical models with Python

CERN Document Server

Karkera, Kiran R

2014-01-01

This is a short, practical guide that allows data scientists to understand the concepts of Graphical models and enables them to try them out using small Python code snippets, without being too mathematically complicated. If you are a data scientist who knows about machine learning and want to enhance your knowledge of graphical models, such as Bayes network, in order to use them to solve real-world problems using Python libraries, this book is for you. This book is intended for those who have some Python and machine learning experience, or are exploring the machine learning field.

Microcystin-LR nanobody screening from an alpaca phage display nanobody library and its expression and application.

Science.gov (United States)

Xu, Chongxin; Yang, Ying; Liu, Liwen; Li, Jianhong; Liu, Xiaoqin; Zhang, Xiao; Liu, Yuan; Zhang, Cunzheng; Liu, Xianjin

2018-04-30

Microcystin-LR (MC-LR) is a type of biotoxin that pollutes the ecological environment and food. The study aimed to obtain new nanobodies from phage nanobody library for determination of MC-LR. The toxin was conjugated to keyhole limpet haemocyanin (KLH) and bovine serum albumin (BSA), respectively, then the conjugates were used as coated antigens for enrichment (coated MC-LR-KLH) and screening (coated MC-LR-BSA) of MC-LR phage nanobodies from an alpaca phage display nanobody library. The antigen-specific phage particles were enriched effectively with four rounds of biopanning. At the last round of enrichment, total 20 positive monoclonal phage nanobodies were obtained from the library, which were analyzed after monoclonal phage enzyme linked immunosorbent assay (ELISA), colony PCR and DNA sequencing. The most three positive nanobody genes, ANAb12, ANAb9 and ANAb7 were cloned into pET26b vector, then the nanobodies were expressed in Escherichia coli BL21 respectively. After being purified, the molecular weight (M.W.) of all nanobodies were approximate 15kDa with sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The purified nanobodies, ANAb12, ANAb9 and ANAb7 were used to establish the indirect competitive ELISA (IC-ELISA) for MC-LR, and their half-maximum inhibition concentrations (IC 50 ) were 0.87, 1.17 and 1.47μg/L, their detection limits (IC 10 ) were 0.06, 0.08 and 0.12μg/L, respectively. All of them showed strong cross-reactivity (CRs) of 82.7-116.9% for MC-RR, MC-YR and MC-WR, and weak CRs of less than 4.56% for MC-LW, less than 0.1% for MC-LY and MC-LF. It was found that all the IC-ELISAs for MC-LR spiked in tap water samples detection were with good accuracy, stability and repeatability, their recoveries were 84.0-106.5%, coefficient of variations (CVs) were 3.4-10.6%. These results showed that IC-ELISA based on the nanobodies from the alpaca phage display antibody library were promising for high sensitive determination of multiple

Mass Digitisation by Libraries: Issues concerning Organisation, Quality and Efficiency

Directory of Open Access Journals (Sweden)

Astrid Verheusen

2008-03-01

Full Text Available Ever since the world-wide web made it possible to display graphics on the Internet, libraries have been scanning their older documents and pictures to provide access to them. From the middle of the 1990s thousands of libraries of all sizes began scanning parts of their collections, provided these with metadata and made them available on the web. The emphasis in these first, rather small, digitisation projects was on experimenting with different techniques for both scanning and building interfaces for the Internet. Along the way, methods for quality assurance, project management and business models became more professional. In line with the progress made in the field of digitisation, a profound knowledge of best practices has been developed. However, this knowledge is not available for all cultural heritage institutions who want to digitise their collections. Most of the smaller institutions lack experience and, moreover, the means to digitise in an efficient way. At the same time, the larger libraries are moving towards large-scale digitisation of historical texts while Google has already digitised millions of books from several libraries around the world. Although many libraries welcome the unprecedented access to all this information, Google has also been criticized for the inferior quality of their images, the emphasis on the English language, the violation of copyright laws and the lack of attention for preservation issues. The question therefore arises: can libraries do better than Google?

Detection and quantification of microcystins (cyanobacterial hepatotoxins) with recombinant antibody fragments isolated from a naïve human phage display library.

Science.gov (United States)

McElhiney, J; Lawton, L A; Porter, A J

2000-12-01

Single-chain antibody fragments against the cyanobacterial hepatotoxin microcystin-LR were isolated from a naive human phage display library and expressed in Escherichia coli. In competition enzyme-linked immunosorbent assay (ELISA), the most sensitive antibody clone selected from the library detected free microcystin-LR with an IC(50) value of 4 microM. It was found to cross react with three other microcystin variants - microcystin-RR, microcystin-LW and microcystin-LF - and detected microcystins in extracts of the cyanobacterium Microcystis aeruginosa, found to contain the toxins by high-performance liquid chromatography (HPLC). The quantification of microcystins in these extracts by ELISA and HPLC showed good correlation. Although the antibody isolated in this study was considerably less sensitive than the polyclonal and monoclonal antibodies already available for microcystin detection, phage display technology represents a cheaper, more rapid alternative for the production of anti-microcystin antibodies than the methods currently in use.

Scribl: an HTML5 Canvas-based graphics library for visualizing genomic data over the web.

Science.gov (United States)

Miller, Chase A; Anthony, Jon; Meyer, Michelle M; Marth, Gabor

2013-02-01

High-throughput biological research requires simultaneous visualization as well as analysis of genomic data, e.g. read alignments, variant calls and genomic annotations. Traditionally, such integrative analysis required desktop applications operating on locally stored data. Many current terabyte-size datasets generated by large public consortia projects, however, are already only feasibly stored at specialist genome analysis centers. As even small laboratories can afford very large datasets, local storage and analysis are becoming increasingly limiting, and it is likely that most such datasets will soon be stored remotely, e.g. in the cloud. These developments will require web-based tools that enable users to access, analyze and view vast remotely stored data with a level of sophistication and interactivity that approximates desktop applications. As rapidly dropping cost enables researchers to collect data intended to answer questions in very specialized contexts, developers must also provide software libraries that empower users to implement customized data analyses and data views for their particular application. Such specialized, yet lightweight, applications would empower scientists to better answer specific biological questions than possible with general-purpose genome browsers currently available. Using recent advances in core web technologies (HTML5), we developed Scribl, a flexible genomic visualization library specifically targeting coordinate-based data such as genomic features, DNA sequence and genetic variants. Scribl simplifies the development of sophisticated web-based graphical tools that approach the dynamism and interactivity of desktop applications. Software is freely available online at http://chmille4.github.com/Scribl/ and is implemented in JavaScript with all modern browsers supported.

Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit.

Science.gov (United States)

Xu, Jing; Wong, Kevin; Jian, Yifan; Sarunic, Marinko V

2014-02-01

In this report, we describe a graphics processing unit (GPU)-accelerated processing platform for real-time acquisition and display of flow contrast images with Fourier domain optical coherence tomography (FDOCT) in mouse and human eyes in vivo. Motion contrast from blood flow is processed using the speckle variance OCT (svOCT) technique, which relies on the acquisition of multiple B-scan frames at the same location and tracking the change of the speckle pattern. Real-time mouse and human retinal imaging using two different custom-built OCT systems with processing and display performed on GPU are presented with an in-depth analysis of performance metrics. The display output included structural OCT data, en face projections of the intensity data, and the svOCT en face projections of retinal microvasculature; these results compare projections with and without speckle variance in the different retinal layers to reveal significant contrast improvements. As a demonstration, videos of real-time svOCT for in vivo human and mouse retinal imaging are included in our results. The capability of performing real-time svOCT imaging of the retinal vasculature may be a useful tool in a clinical environment for monitoring disease-related pathological changes in the microcirculation such as diabetic retinopathy.

Development of a prototype graphic simulation program for severe accident training

International Nuclear Information System (INIS)

Kim, Ko Ryu; Jeong, Kwang Sub; Ha, Jae Joo

2000-05-01

This is a report of the development process and related technologies of severe accident graphic simulators, required in industrial severe accident management and training. Here, we say 'a severe accident graphic simulator' as a graphics add-in system to existing calculation codes, which can show the severe accident phenomena dynamically on computer screens and therefore which can supplement one of main defects of existing calculation codes. With graphic simulators it is fairly easy to see the total behavior of nuclear power plants, where it was very difficult to see only from partial variable numerical information. Moreover, the fast processing and control feature of a graphic simulator can give some opportunities of predicting the severe accident advancement among several possibilities, to one who is not an expert. Utilizing graphic simulators' we expect operators' and TSC members' physical phenomena understanding enhancement from the realistic dynamic behavior of plants. We also expect that severe accident training course can gain better training effects using graphic simulator's control functions and predicting capabilities, and therefore we expect that graphic simulators will be effective decision-aids tools both in sever accident training course and in real severe accident situations. With these in mind, we have developed a prototype graphic simulator having surveyed related technologies, and from this development experiences we have inspected the possibility to build a severe accident graphic simulator. The prototype graphic simulator is developed under IBM PC WinNT environments and is suited to Uljin 3and4 nuclear power plant. When supplied with adequate severe accident scenario as an input, the prototype can provide graphical simulations of plant safety systems' dynamic behaviors. The prototype is composed of several different modules, which are phenomena display module, MELCOR data interface module and graphic database interface module. Main functions of

Practical Tips for Construction of Custom Peptide Libraries and Affinity Selection by Using Commercially Available Phage Display Cloning Systems

Directory of Open Access Journals (Sweden)

Keisuke Fukunaga

2012-01-01

Full Text Available Phage display technology is undoubtedly a powerful tool for affinity selection of target-specific peptide. Commercially available premade phage libraries allow us to take screening in the easiest way. On the other hand, construction of a custom phage library seems to be inaccessible, because several practical tips are absent in instructions. This paper focuses on what should be born in mind for beginners using commercially available cloning kits (Ph.D. with type 3 vector and T7Select systems for M13 and T7 phage, respectively. In the M13 system, Pro or a basic amino acid (especially, Arg should be avoided at the N-terminus of peptide fused to gp3. In both systems, peptides containing odd number(s of Cys should be designed with caution. Also, DNA sequencing of a constructed library before biopanning is highly recommended for finding unexpected bias.

Interactive display of molecular models using a microcomputer system

Science.gov (United States)

Egan, J. T.; Macelroy, R. D.

1980-01-01

A simple, microcomputer-based, interactive graphics display system has been developed for the presentation of perspective views of wire frame molecular models. The display system is based on a TERAK 8510a graphics computer system with a display unit consisting of microprocessor, television display and keyboard subsystems. The operating system includes a screen editor, file manager, PASCAL and BASIC compilers and command options for linking and executing programs. The graphics program, written in USCD PASCAL, involves the centering of the coordinate system, the transformation of centered model coordinates into homogeneous coordinates, the construction of a viewing transformation matrix to operate on the coordinates, clipping invisible points, perspective transformation and scaling to screen coordinates; commands available include ZOOM, ROTATE, RESET, and CHANGEVIEW. Data file structure was chosen to minimize the amount of disk storage space. Despite the inherent slowness of the system, its low cost and flexibility suggests general applicability.

[Peptide phage display in biotechnology and biomedicine].

Science.gov (United States)

Kuzmicheva, G A; Belyavskaya, V A

2016-07-01

To date peptide phage display is one of the most common combinatorial methods used for identifying specific peptide ligands. Phage display peptide libraries containing billions different clones successfully used for selection of ligands with high affinity and selectivity toward wide range of targets including individual proteins, bacteria, viruses, spores, different kind of cancer cells and variety of nonorganic targets (metals, alloys, semiconductors etc.) Success of using filamentous phage in phage display technologies relays on the robustness of phage particles and a possibility to genetically modify its DNA to construct new phage variants with novel properties. In this review we are discussing characteristics of the most known non-commercial peptide phage display libraries of different formats (landscape libraries in particular) and their successful applications in several fields of biotechnology and biomedicine: discovery of peptides with diagnostic values against different pathogens, discovery and using of peptides recognizing cancer cells, trends in using of phage display technologies in human interactome studies, application of phage display technologies in construction of novel nano materials.

Simulated monitor display for CCTV

International Nuclear Information System (INIS)

Steele, B.J.

1982-01-01

Two computer programs have been developed which generate a two-dimensional graphic perspective of the video output produced by a Closed Circuit Television (CCTV) camera. Both programs were primarily written to produce a graphic display simulating the field-of-view (FOV) of a perimeter assessment system as seen on a CCTV monitor. The original program was developed for use on a Tektronix 4054 desktop computer; however, the usefulness of this graphic display program led to the development of a similar program for a Hewlett-Packard 9845B desktop computer. After entry of various input parameters, such as, camera lens and orientation, the programs automatically calculate and graphically plot the locations of various items, e.g., fences, an assessment zone, running men, and intrusion detection sensors. Numerous special effects can be generated to simulate such things as roads, interior walls, or sides of buildings. Other objects can be digitized and entered into permanent memory similar to the running men. With this type of simulated monitor perspective, proposed camera locations with respect to fences and a particular assessment zone can be rapidly evaluated without the costly time delays and expenditures associated with field evaluation

Washington Public Libraries Online: Collaborating in Cyberspace.

Science.gov (United States)

Wildin, Nancy

1997-01-01

Discussion of public libraries, the Internet, and the World Wide Web focuses on development of a Web site in Washington. Highlights include access to the Internet through online public access catalogs; partnerships between various types of libraries; hardware and software; HTML training; content design; graphics design; marketing; evaluation; and…

Bibliographic Displays in OPACs and Web Catalogs: How Well Do They Comply with Display Guidelines?

Science.gov (United States)

Cherry, Joan M.

1998-01-01

Evaluation of data from assessments of full bibliographic displays in academic library OPACs (online public access catalogs) and World Wide Web catalogs against a checklist of desirable features found that OPAC displays scored 58% and Web displays scored 60%. Discusses weaknesses, focusing on those found in the majority of the displays…

Mikado: A graphic program

Science.gov (United States)

Secretan, Y.

A discussion of the modular program Mikado is presented. Mikado was developed with the goal of creating a flexible graphic tool to display and help analyze the results of finite element fluid flow computations. Mikado works on unstructured meshes, with elements of mixed geometric type, but also offers the possibility of using structured meshes. The program can be operated by both menu and mouse (interactive), or by command file (batch). Mikado is written in FORTRAN, except for a few system dependent subroutines which are in C. It runs presently on Silicon Graphics' workstations and could be easily ported to the IBM-RISC System/6000 family of workstations.

Graphics and Statistics for Cardiology: Data visualisation for meta-analysis.

Science.gov (United States)

Kiran, Amit; Crespillo, Abel Pérez; Rahimi, Kazem

2017-01-01

Graphical displays play a pivotal role in understanding data sets and disseminating results. For meta-analysis, they are instrumental in presenting findings from multiple studies. This report presents guidance to authors wishing to submit graphical displays as part of their meta-analysis to a clinical cardiology journal, such as HeartWhen using graphical displays for meta-analysis, we recommend the following: Use a flow diagram to describe the number of studies returned from the initial search, the inclusion/exclusion criteria applied and the final number of studies used in the meta-analysis.Present results from the meta-analysis using a figure that incorporates a forest plot and underlying (tabulated) statistics, including test for heterogeneity.Use displays such as funnel plot (minimum 10 studies) and Galbraith plot to visually present distribution of effect sizes or associations in order to evaluate small-study effects and publication bias).For meta-regression, the bubble plot is a useful display for assessing associations by study-level factors.Final checks on graphs, such as appropriate use of axis scale, line pattern, text size and graph resolution, should always be performed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Engineering computer graphics in gas turbine engine design, analysis and manufacture

Science.gov (United States)

Lopatka, R. S.

1975-01-01

A time-sharing and computer graphics facility designed to provide effective interactive tools to a large number of engineering users with varied requirements was described. The application of computer graphics displays at several levels of hardware complexity and capability is discussed, with examples of graphics systems tracing gas turbine product development, beginning with preliminary design through manufacture. Highlights of an operating system stylized for interactive engineering graphics is described.

The End of the Rainbow? Color Schemes for Improved Data Graphics

Science.gov (United States)

Light, Adam; Bartlein, Patrick J.

2004-10-01

Modern computer displays and printers enable the widespread use of color in scientific communication, but the expertise for designing effective graphics has not kept pace with the technology for producing them. Historically, even the most prestigious publications have tolerated high defect rates in figures and illustrations, and technological advances that make creating and reproducing graphics easier do not appear to have decreased the frequency of errors. Flawed graphics consequently beget more flawed graphics as authors emulate published examples. Color has the potential to enhance communication, but design mistakes can result in color figures that are less effective than gray scale displays of the same data. Empirical research on human subjects can build a fundamental understanding of visual perception and scientific methods can be used to evaluate existing designs, but creating effective data graphics is a design task and not fundamentally a scientific pursuit. Like writing well, creating good data graphics requires a combination of formal knowledge and artistic sensibility tempered by experience: a combination of ``substance, statistics, and design''.

ELBERETH. A subroutine library for graphic representation from J. E. N. Fusion Division; ELBERETH. Libreria de subrutinas para representacion grafica de la Division de Fusion de la JEN

Energy Technology Data Exchange (ETDEWEB)

Guasp, J

1981-07-01

A library for graphic representation, named ELBERETH, has been built, all the subroutines have been written in FORTRAN-V for the UN IVAC-1100/80 computers from JEN and are able to produce drawing on the CALCOMP-936 plotter, as well as with the printers and on the UTS-400 terminal screen. The library can yield two or three-dimensional plots as rail as level lines, all of them under free format or in several standard ones either. It allows to be used on a simplified way by direct reading from a file. It has been constructed too with a flexible structure to allow forth coming extensions. (Author) 4 refs.

The effect of alternative graphical displays used to present the benefits of antibiotics for sore throat on decisions about whether to seek treatment: a randomized trial.

Science.gov (United States)

Carling, Cheryl L L; Kristoffersen, Doris Tove; Flottorp, Signe; Fretheim, Atle; Oxman, Andrew D; Schünemann, Holger J; Akl, Elie A; Herrin, Jeph; MacKenzie, Thomas D; Montori, Victor M

2009-08-01

We conducted an Internet-based randomized trial comparing four graphical displays of the benefits of antibiotics for people with sore throat who must decide whether to go to the doctor to seek treatment. Our objective was to determine which display resulted in choices most consistent with participants' values. This was the first of a series of televised trials undertaken in cooperation with the Norwegian Broadcasting Company. We recruited adult volunteers in Norway through a nationally televised weekly health program. Participants went to our Web site and rated the relative importance of the consequences of treatment using visual analogue scales (VAS). They viewed the graphical display (or no information) to which they were randomized and were asked to decide whether to go to the doctor for an antibiotic prescription. We compared four presentations: face icons (happy/sad) or a bar graph showing the proportion of people with symptoms on day three with and without treatment, a bar graph of the average duration of symptoms, and a bar graph of proportion with symptoms on both days three and seven. Before completing the study, all participants were shown all the displays and detailed patient information about the treatment of sore throat and were asked to decide again. We calculated a relative importance score (RIS) by subtracting the VAS scores for the undesirable consequences of antibiotics from the VAS score for the benefit of symptom relief. We used logistic regression to determine the association between participants' RIS and their choice. 1,760 participants completed the study. There were statistically significant differences in the likelihood of choosing to go to the doctor in relation to different values (RIS). Of the four presentations, the bar graph of duration of symptoms resulted in decisions that were most consistent with the more fully informed second decision. Most participants also preferred this presentation (38%) and found it easiest to understand (37

LOFT advanced control room operator diagnostic and display system (ODDS)

International Nuclear Information System (INIS)

Larsen, D.G.; Robb, T.C.

1980-01-01

The Loss-of-Fluid Test (LOFT) Reactor Facility in Idaho includes a highly instrumented nuclear reactor operated by the Department of Energy for the purpose of establishing nuclear safety requirements. The results of the development and installation into LOFT of an Operator Diagnostic and Display System (ODDS) are presented. The ODDS is a computer-based graphics display system centered around a PRIME 550 computer with several RAMTEK color graphic display units located within the control room and available to the reactor operators. Use of computer-based color graphics to aid the reactor operator is discussed. A detailed hardware description of the LOFT data system and the ODDS is presented. Methods and problems of backfitting the ODDS equipment into the LOFT plant are discussed

News from the Library: Digital signage: what is it?

CERN Multimedia

2012-01-01

As you might know, "digital signage" is a form of electronic display that shows information, advertising and other messages in both public and private environments.   If you visited the Library lately, you probably discovered that something has changed in the way we inform library users of how our collections and services are evolving. A screen has now replaced the traditional shelf or showcase where libraries usually display new book acquisitions. This new digital showcase dynamically displays new book and ebook acquisitions in the Library, new titles available in the Bookshop, and most downloaded ebooks. The same content will be soon displayed also on the CERN digital signage network.

Development of a prototype graphic simulation program for severe accident training

Energy Technology Data Exchange (ETDEWEB)

Kim, Ko Ryu; Jeong, Kwang Sub; Ha, Jae Joo

2000-05-01

This is a report of the development process and related technologies of severe accident graphic simulators, required in industrial severe accident management and training. Here, we say 'a severe accident graphic simulator' as a graphics add-in system to existing calculation codes, which can show the severe accident phenomena dynamically on computer screens and therefore which can supplement one of main defects of existing calculation codes. With graphic simulators it is fairly easy to see the total behavior of nuclear power plants, where it was very difficult to see only from partial variable numerical information. Moreover, the fast processing and control feature of a graphic simulator can give some opportunities of predicting the severe accident advancement among several possibilities, to one who is not an expert. Utilizing graphic simulators' we expect operators' and TSC members' physical phenomena understanding enhancement from the realistic dynamic behavior of plants. We also expect that severe accident training course can gain better training effects using graphic simulator's control functions and predicting capabilities, and therefore we expect that graphic simulators will be effective decision-aids tools both in sever accident training course and in real severe accident situations. With these in mind, we have developed a prototype graphic simulator having surveyed related technologies, and from this development experiences we have inspected the possibility to build a severe accident graphic simulator. The prototype graphic simulator is developed under IBM PC WinNT environments and is suited to Uljin 3and4 nuclear power plant. When supplied with adequate severe accident scenario as an input, the prototype can provide graphical simulations of plant safety systems' dynamic behaviors. The prototype is composed of several different modules, which are phenomena display module, MELCOR data interface module and graphic database

Enhancement of graphic user interface data acquisition of small angle neutron scattering

International Nuclear Information System (INIS)

Abd Aziz Muhammad; Abd Jalil Abd Hamid

2004-01-01

This paper discusses the activities of the development of data acquisition software for PC, which capable of controlling instrument via IEEE-488 and graphic visualization for small angle neutron scattering (SANS) runs in DOS mode. With the help of outstanding free ware graphic library for DOS, this software has enhanced the efficiency of graphic visualization for SANSLab data acquisition. Featuring easy-to-use graphical user interface (GUI) and several other built-in tools for convenience, this software can be manipulated with the mouse or the keyboard. This software can be converted into an inexpensive data acquisition system for SANS. (Author)

Directed Selection of Recombinant Human Monoclonal Antibodies to Herpes Simplex Virus Glycoproteins from Phage Display Libraries

Science.gov (United States)

Sanna, Pietro Paolo; Williamson, R. Anthony; de Logu, Alessandro; Bloom, Floyd E.; Burton, Dennis R.

1995-07-01

Human monoclonal antibodies have considerable potential in the prophylaxis and treatment of viral disease. However, only a few such antibodies suitable for clinical use have been produced to date. We have previously shown that large panels of human recombinant monoclonal antibodies against a plethora of infectious agents, including herpes simplex virus types 1 and 2, can be established from phage display libraries. Here we demonstrate that facile cloning of recombinant Fab fragments against specific viral proteins in their native conformation can be accomplished by panning phage display libraries against viral glycoproteins "captured" from infected cell extracts by specific monoclonal antibodies immobilized on ELISA plates. We have tested this strategy by isolating six neutralizing recombinant antibodies specific for herpes simplex glycoprotein gD or gB, some of which are against conformationally sensitive epitopes. By using defined monoclonal antibodies for the antigen-capture step, this method can be used for the isolation of antibodies to specific regions and epitopes within the target viral protein. For instance, monoclonal antibodies to a nonneutralizing epitope can be used in the capture step to clone antibodies to neutralizing epitopes, or antibodies to a neutralizing epitope can be used to clone antibodies to a different neutralizing epitope. Furthermore, by using capturing antibodies to more immunodominant epitopes, one can direct the cloning to less immunogenic ones. This method should be of value in generating antibodies to be used both in the prophylaxis and treatment of viral infections and in the characterization of the mechanisms of antibody protective actions at the molecular level.

GPU Boosted CNN Simulator Library for Graphical Flow-Based Programmability

Directory of Open Access Journals (Sweden)

Balázs Gergely Soós

2009-01-01

Full Text Available A graphical environment for CNN algorithm development is presented. The new generation of graphical cards with many general purpose processing units introduces the massively parallel computing into PC environment. Universal Machine on Flows- (UMF like notation, highlighting image flows and operations, is a useful tool to describe image processing algorithms. This documentation step can be turned into modeling using our framework backed with MATLAB Simulink and the power of a video card. This latter relatively cheap extension enables a convenient and fast analysis of CNN dynamics and complex algorithms. Comparison with other PC solutions is also presented. For single template execution, our approach yields run times 40x faster than that of the widely used Candy simulator. In the case of simpler algorithms, real-time execution is also possible.

Refreshing Refreshable Braille Displays.

Science.gov (United States)

Russomanno, Alexander; O'Modhrain, Sile; Gillespie, R Brent; Rodger, Matthew W M

2015-01-01

The increased access to books afforded to blind people via e-publishing has given them long-sought independence for both recreational and educational reading. In most cases, blind readers access materials using speech output. For some content such as highly technical texts, music, and graphics, speech is not an appropriate access modality as it does not promote deep understanding. Therefore blind braille readers often prefer electronic braille displays. But, these are prohibitively expensive. The search is on, therefore, for a low-cost refreshable display that would go beyond current technologies and deliver graphical content as well as text. And many solutions have been proposed, some of which reduce costs by restricting the number of characters that can be displayed, even down to a single braille cell. In this paper, we demonstrate that restricting tactile cues during braille reading leads to poorer performance in a letter recognition task. In particular, we show that lack of sliding contact between the fingertip and the braille reading surface results in more errors and that the number of errors increases as a function of presentation speed. These findings suggest that single cell displays which do not incorporate sliding contact are likely to be less effective for braille reading.

HTML 5 Displays for On-Board Flight Systems

Science.gov (United States)

Silva, Chandika

2016-01-01

During my Internship at NASA in the summer of 2016, I was assigned to a project which dealt with developing a web-server that would display telemetry and other system data using HTML 5, JavaScript, and CSS. By doing this, it would be possible to view the data across a variety of screen sizes, and establish a standard that could be used to simplify communication and software development between NASA and other countries. Utilizing a web- approach allowed us to add in more functionality, as well as make the displays more aesthetically pleasing for the users. When I was assigned to this project my main task was to first establish communication with the current display server. This display server would output data from the on-board systems in XML format. Once communication was established I was then asked to create a dynamic telemetry table web page that would update its header and change as new information came in. After this was completed, certain minor functionalities were added to the table such as a hide column and filter by system option. This was more for the purpose of making the table more useful for the users, as they can now filter and view relevant data. Finally my last task was to create a graphical system display for all the systems on the space craft. This was by far the most challenging part of my internship as finding a JavaScript library that was both free and contained useful functions to assist me in my task was difficult. In the end I was able to use the JointJs library and accomplish the task. With the help of my mentor and the HIVE lab team, we were able to establish stable communication with the display server. We also succeeded in creating a fully dynamic telemetry table and in developing a graphical system display for the advanced modular power system. Working in JSC for this internship has taught me a lot about coding in JavaScript and HTML 5. I was also introduced to the concept of developing software as a team, and exposed to the different

Drawing a Crowd: Graphic Novel Events Are Great Ways to Generate Excitement

Science.gov (United States)

MacDonald, Heidi

2004-01-01

As graphic novels grow in popularity, with teen readers, libraries are finding the world of comics, manga, and anime a fertile field for inspiring events, as well as a great way to promote libraries to teens in general. These events can range from simple--a reading/signing--to elaborate--workshops, or even a mini convention. All provide a unique…

The Digital Space Shuttle, 3D Graphics, and Knowledge Management

Science.gov (United States)

Gomez, Julian E.; Keller, Paul J.

2003-01-01

The Digital Shuttle is a knowledge management project that seeks to define symbiotic relationships between 3D graphics and formal knowledge representations (ontologies). 3D graphics provides geometric and visual content, in 2D and 3D CAD forms, and the capability to display systems knowledge. Because the data is so heterogeneous, and the interrelated data structures are complex, 3D graphics combined with ontologies provides mechanisms for navigating the data and visualizing relationships.

Influence of Colour on Acquisition and Generalisation of Graphic Symbols

Science.gov (United States)

Hetzroni, O. E.; Ne'eman, A.

2013-01-01

Background: Children with autism may benefit from using graphic symbols for their communication, language and literacy development. The purpose of this study was to investigate the influence of colour versus grey-scale displays on the identification of graphic symbols using a computer-based intervention. Method: An alternating treatment design was…

HiRel: Hybrid Automated Reliability Predictor (HARP) integrated reliability tool system, (version 7.0). Volume 4: HARP Output (HARPO) graphics display user's guide

Science.gov (United States)

Sproles, Darrell W.; Bavuso, Salvatore J.

1994-01-01

The Hybrid Automated Reliability Predictor (HARP) integrated Reliability (HiRel) tool system for reliability/availability prediction offers a toolbox of integrated reliability/availability programs that can be used to customize the user's application in a workstation or nonworkstation environment. HiRel consists of interactive graphical input/output programs and four reliability/availability modeling engines that provide analytical and simulative solutions to a wide host of highly reliable fault-tolerant system architectures and is also applicable to electronic systems in general. The tool system was designed at the outset to be compatible with most computing platforms and operating systems and some programs have been beta tested within the aerospace community for over 8 years. This document is a user's guide for the HiRel graphical postprocessor program HARPO (HARP Output). HARPO reads ASCII files generated by HARP. It provides an interactive plotting capability that can be used to display alternate model data for trade-off analyses. File data can also be imported to other commercial software programs.

Interactive graphics for data analysis principles and examples

CERN Document Server

Theus, Martin

2008-01-01

Introduction PRINCIPLESInteractivity Queries Selection and Linked Highlighting Linking AnalysesInteracting with Graphics Examining a Single Variable Categorical DataContinuous DataTransforming Data Weighted Plots Interactions between Two VariablesTwo Categorical VariablesOne Categorical Variable and One Continuous VariableTwo Continuous VariablesMultidimensional Plots Mosaic PlotsParallel Coordinate Plots Trellis Displays Plot Ensembles and Statistical ModelsResponse ModelsANOVALoglinear ModelsGeographical DataMore Interactivity Sorting and Ordering Zooming Multiple ViewsInteractive Graphics ?

A graphics approach in the design of the dual air density Explorer satellites

Science.gov (United States)

Mcdougal, D. S.

1975-01-01

A computer program was developed to generate a graphics display of the Dual Air Density (DAD) Explorer satellites which aids in the engineering and scientific design. The program displays a two-dimensional view of both spacecraft and their surface features from any direction. The graphics have been an indispensable tool in the design, analysis, and understanding of the critical locations of the various surface features for both satellites.

Identifying Bacterial Immune Evasion Proteins Using Phage Display.

Science.gov (United States)

Fevre, Cindy; Scheepmaker, Lisette; Haas, Pieter-Jan

2017-01-01

Methods aimed at identification of immune evasion proteins are mainly rely on in silico prediction of sequence, structural homology to known evasion proteins or use a proteomics driven approach. Although proven successful these methods are limited by a low efficiency and or lack of functional identification. Here we describe a high-throughput genomic strategy to functionally identify bacterial immune evasion proteins using phage display technology. Genomic bacterial DNA is randomly fragmented and ligated into a phage display vector that is used to create a phage display library expressing bacterial secreted and membrane bound proteins. This library is used to select displayed bacterial secretome proteins that interact with host immune components.

Isolation of Osteosarcoma-Associated Human Antibodies from a Combinatorial Fab Phage Display Library

Directory of Open Access Journals (Sweden)

Carmela Dantas-Barbosa

2009-01-01

Full Text Available Osteosarcoma, a highly malignant disease, is the most common primary bone tumor and is frequently found in children and adolescents. In order to isolate antibodies against osteosarcoma antigens, a combinatorial osteosarcoma Fab library displayed on the surface of phages was used. After three rounds of selection on the surface of tumor cells, several osteosarcoma-reactive Fabs were detected. From these Fabs, five were better characterized, and despite having differences in their VH (heavy chain variable domain and Vκ (kappa chain variable domain regions, they all bound to a protein with the same molecular mass. Further analysis by cell ELISA and immunocytochemistry suggested that the Fabs recognize a membrane-associated tumor antigen expressed in higher amounts in neoplasic cells than in normal tissue. These results suggest that the human Fabs selected in this work are a valuable tool for the study of this neoplasia.

Stochastic Analysis of a Queue Length Model Using a Graphics Processing Unit

Czech Academy of Sciences Publication Activity Database

Přikryl, Jan; Kocijan, J.

2012-01-01

Roč. 5, č. 2 (2012), s. 55-62 ISSN 1802-971X R&D Projects: GA MŠk(CZ) MEB091015 Institutional support: RVO:67985556 Keywords : graphics processing unit * GPU * Monte Carlo simulation * computer simulation * modeling Subject RIV: BC - Control Systems Theory http://library.utia.cas.cz/separaty/2012/AS/prikryl-stochastic analysis of a queue length model using a graphics processing unit.pdf

Flexible Smart Display with Integrated Graphics Rasterizor using ...

African Journals Online (AJOL)

SG-TFTs and other similar technologies can potentially enable fabricating electronics directly on arbitrary substrates. This would further enable integration of embedded intelligence in devices that would enhance the current functionalists of displays. This paper is an effort in this direction as it undertakes a study to design a ...

Display hardware

International Nuclear Information System (INIS)

Myers, D.R.

1983-01-01

To appreciate the limitations and possibilities of computer graphics it is necessary to have some acquaintance with the available technology. The aim of this chapter is to mention briefly the different display types and their 'ball-park' price ranges. It must be stressed that prices change rapidly, and so those quoted here are only intended to give an idea of the cost at the time of writing.

TIGER: A graphically interactive grid system for turbomachinery applications

Science.gov (United States)

Shih, Ming-Hsin; Soni, Bharat K.

1992-01-01

Numerical grid generation algorithm associated with the flow field about turbomachinery geometries is presented. Graphical user interface is developed with FORMS Library to create an interactive, user-friendly working environment. This customized algorithm reduces the man-hours required to generate a grid associated with turbomachinery geometry, as compared to the use of general-purpose grid generation softwares. Bezier curves are utilized both interactively and automatically to accomplish grid line smoothness and orthogonality. Graphical User Interactions are provided in the algorithm, allowing the user to design and manipulate the grid lines with a mouse.

Next-Generation Sequencing of Antibody Display Repertoires

Directory of Open Access Journals (Sweden)

Romain Rouet

2018-02-01

Full Text Available In vitro selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders can be selected from diverse repertoires. Here, we review strategies for the next-generation sequencing (NGS of phage- and other antibody-display libraries, as well as NGS platforms and analysis tools. Moreover, we discuss recent examples relating to the use of NGS to assess library diversity, clonal enrichment, and affinity maturation.

Emergent features and perceptual objects: re-examining fundamental principles in analogical display design.

Science.gov (United States)

Holt, Jerred; Bennett, Kevin B; Flach, John M

2015-01-01

Two sets of design principles for analogical visual displays, based on the concepts of emergent features and perceptual objects, are described. An interpretation of previous empirical findings for three displays (bar graph, polar graphic, alphanumeric) is provided from both perspectives. A fourth display (configural coordinate) was designed using principles of ecological interface design (i.e. direct perception). An experiment was conducted to evaluate performance (accuracy and latency of state identification) with these four displays. Numerous significant effects were obtained and a clear rank ordering of performance emerged (from best to worst): configural coordinate, bar graph, alphanumeric and polar graphic. These findings are consistent with principles of design based on emergent features; they are inconsistent with principles based on perceptual objects. Some limitations of the configural coordinate display are discussed and a redesign is provided. Practitioner Summary: Principles of ecological interface design, which emphasise the quality of very specific mappings between domain, display and observer constraints, are described; these principles are applicable to the design of all analogical graphical displays.

Knowledge based development of graphic display systems

International Nuclear Information System (INIS)

Woods, D.D.

1985-01-01

Most human factors guidelines on computer display design attempt to ensure that human sensory limits are not strained or that users can potentially access data. While this is a necessary and too often an overlooked step in interface design, it does not address issues about how to use computer displays to aid human performance at domain tasks. This challenge to human factors guidance is particularly acute in complex environments such as nuclear power plants where the goal is more than a useable interface system; the interface must support effective human performance at tasks like situation assessment, fault management, problem solving and planning. Studies of human performance in complex domains reveal that human-machine performance failures can often be linked to problems in information handling - data overload, getting lost, keyhole effects, tunnel vision to name but a few. All of these information handling problems represent manifestations of an inability to find, integrate or interpret the ''right'' data at the ''right'' time, i.e., failures where critical information is not detected among the ambient data load, where critical information is not assembled from data distributed over time or over space; and where critical information is not looked for because of misunderstandings or erroneous assumptions (cf., Woods, 1985). Problems of this kind illustrate that the potential to see, read, or access data does not guarantee successful user information extraction. The result is a need for research and guidance on design for enhanced information extraction in addition to design for data availability

X-Windows Widget for Image Display

Science.gov (United States)

Deen, Robert G.

2011-01-01

XvicImage is a high-performance XWindows (Motif-compliant) user interface widget for displaying images. It handles all aspects of low-level image display. The fully Motif-compliant image display widget handles the following tasks: (1) Image display, including dithering as needed (2) Zoom (3) Pan (4) Stretch (contrast enhancement, via lookup table) (5) Display of single-band or color data (6) Display of non-byte data (ints, floats) (7) Pseudocolor display (8) Full overlay support (drawing graphics on image) (9) Mouse-based panning (10) Cursor handling, shaping, and planting (disconnecting cursor from mouse) (11) Support for all user interaction events (passed to application) (12) Background loading and display of images (doesn't freeze the GUI) (13) Tiling of images.

Computer and computer graphics support for the ALARA program

International Nuclear Information System (INIS)

Paine, D.; Hall, C.J.

1984-01-01

Computer programs have been developed which support three aspects of the ALARA program at Rockwell Hanford Operations (RHO): 1) Setting annual dose and skin contamination goals, 2) Analyzing trends in operational organizations' dose, numbers of skin contaminations, or radiation occurrences, and 3) Presenting graphic displays to enhance worker safety awareness. Programs have been written which search dosemetry files and produce histograms of annual occupational exposure and skin contamination histories utilizing the DISSPLA software or a desk top color graphics terminal. These programs and associated graphics are used to assemble dose and skin contamination information in a summary format so that ALARA teams can assess the past year's performance and establish reduction goals for the coming year. In addition, the graphics provide a management tool for recognizing desirable or undesirable trends in an organization's occupational dose or number of skin contaminations. Desk top graphics capabilities have been used to display safety-related data to enhance management review and worker awareness of radiological and industrial safety conditions in the work area. The following graphs are prepared on a monthly basis: 1) Numbers of skin contaminations company wide and for specific operating organizations within the company, 2) Numbers of radiation occurrences, 3) Dose histories for specific operational organizations, 4) Numbers of OSHA recordable incidents, 5) OSHA recordable incident rates and severity levels and 6) Lost workday cases

A graphics based remote handling control system

International Nuclear Information System (INIS)

Leinemann, K.

1984-08-01

A control and simulation system with an interactive graphic man-machine interface is proposed for the articulated boom in JET. The system shall support 1. the study of boom movements in the planning phase, 2. the training of operators by appropriate simulations, 3. the programming of boom movements, and 4. the on-line control of the boom. A combination of computer graphic display and TV-images is proposed for providing optimum recognition of the actual situation and for echoing to the operator actions. (orig.) [de

Digital Raster Graphics (DRG) UTM NAD 83 Clipped

Data.gov (United States)

Kansas Data Access and Support Center — The Digital Raster Graphic (DRG) is a raster image of a scanned USGS topographic map including the collar information, georeferenced to the UTM grid. For display...

Digital Raster Graphics (DRG) UTM NAD 27 Clipped

Data.gov (United States)

Kansas Data Access and Support Center — The Digital Raster Graphic (DRG) is a raster image of a scanned USGS topographic map including the collar information, georeferenced to the UTM grid. For display...

Advanced computer graphics techniques as applied to the nuclear industry

International Nuclear Information System (INIS)

Thomas, J.J.; Koontz, A.S.

1985-08-01

Computer graphics is a rapidly advancing technological area in computer science. This is being motivated by increased hardware capability coupled with reduced hardware costs. This paper will cover six topics in computer graphics, with examples forecasting how each of these capabilities could be used in the nuclear industry. These topics are: (1) Image Realism with Surfaces and Transparency; (2) Computer Graphics Motion; (3) Graphics Resolution Issues and Examples; (4) Iconic Interaction; (5) Graphic Workstations; and (6) Data Fusion - illustrating data coming from numerous sources, for display through high dimensional, greater than 3-D, graphics. All topics will be discussed using extensive examples with slides, video tapes, and movies. Illustrations have been omitted from the paper due to the complexity of color reproduction. 11 refs., 2 figs., 3 tabs

Statistical analysis and data display an intermediate course with examples in R

CERN Document Server

Heiberger, Richard M

2015-01-01

This contemporary presentation of statistical methods features extensive use of graphical displays for exploring data and for displaying the analysis. The authors demonstrate how to analyze data—showing code, graphics, and accompanying tabular listings—for all the methods they cover. They emphasize how to construct and interpret graphs. They discuss principles of graphical design. They identify situations where visual impressions from graphs may need confirmation from traditional tabular results. All chapters have exercises. The authors provide and discuss R functions for all the new graphical display formats. All graphs and tabular output in the book were constructed using these functions. Complete R scripts for all examples and figures are provided for readers to use as models for their own analyses. This book can serve as a standalone text for statistics majors at the master’s level and for other quantitatively oriented disciplines at the doctoral level, and as a reference book for researchers. In-de...

Computer graphics application in the engineering design integration system

Science.gov (United States)

Glatt, C. R.; Abel, R. W.; Hirsch, G. N.; Alford, G. E.; Colquitt, W. N.; Stewart, W. A.

1975-01-01

The computer graphics aspect of the Engineering Design Integration (EDIN) system and its application to design problems were discussed. Three basic types of computer graphics may be used with the EDIN system for the evaluation of aerospace vehicles preliminary designs: offline graphics systems using vellum-inking or photographic processes, online graphics systems characterized by direct coupled low cost storage tube terminals with limited interactive capabilities, and a minicomputer based refresh terminal offering highly interactive capabilities. The offline line systems are characterized by high quality (resolution better than 0.254 mm) and slow turnaround (one to four days). The online systems are characterized by low cost, instant visualization of the computer results, slow line speed (300 BAUD), poor hard copy, and the early limitations on vector graphic input capabilities. The recent acquisition of the Adage 330 Graphic Display system has greatly enhanced the potential for interactive computer aided design.

Operational computer graphics in the flight dynamics environment

Science.gov (United States)

Jeletic, James F.

1989-01-01

Over the past five years, the Flight Dynamics Division of the National Aeronautics and Space Administration's (NASA's) Goddard Space Flight Center has incorporated computer graphics technology into its operational environment. In an attempt to increase the effectiveness and productivity of the Division, computer graphics software systems have been developed that display spacecraft tracking and telemetry data in 2-d and 3-d graphic formats that are more comprehensible than the alphanumeric tables of the past. These systems vary in functionality from real-time mission monitoring system, to mission planning utilities, to system development tools. Here, the capabilities and architecture of these systems are discussed.

Virtual digital library

Science.gov (United States)

Thoma, George R.

1996-03-01

The virtual digital library, a concept that is quickly becoming a reality, offers rapid and geography-independent access to stores of text, images, graphics, motion video and other datatypes. Furthermore, a user may move from one information source to another through hypertext linkages. The projects described here further the notion of such an information paradigm from an end user viewpoint.

Computer generated movies to display biotelemetry data

International Nuclear Information System (INIS)

White, G.C.

1979-01-01

The three dimensional nature of biotelemetry data (x, y, time) makes them difficult to comprehend. Graphic displays provide a means of extracting information and analyzing biotelemetry data. The extensive computer graphics facilities at Los Alamos Scientific Laboratory have been utilized to analyze elk biotelemetry data. Fixes have been taken weekly for 14 months on 14 animals'. The inadequacy of still graphic displays to portray the time dimension of this data has lead to the use of computer generated movies to help grasp time relationships. A computer movie of the data from one animal demonstrates habitat use as a function of time, while a movie of 2 or more animals illustrates the correlations between the animals movements. About 2 hours of computer time were required to generate the movies for each animal for 1 year of data. The cost of the movies is quite small relative to the cost of collecting the data, so that computer generated movies are a reasonable method to depict biotelemetry data

Merchandising Techniques and Libraries.

Science.gov (United States)

Green, Sylvie A.

1981-01-01

Proposes that libraries employ modern booksellers' merchandising techniques to improve circulation of library materials. Using displays in various ways, the methods and reasons for weeding out books, replacing worn book jackets, and selecting new books are discussed. Suggestions for learning how to market and 11 references are provided. (RBF)

Library Locations

Data.gov (United States)

Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Carnegie Library of Pittsburgh locations including address, coordinates, phone number, square footage, and standard operating hours. The map below does not display...

Graphical Environment Tools for Application to Gamma-Ray Energy Tracking Arrays

Energy Technology Data Exchange (ETDEWEB)

Todd, Richard A. [RIS Corp.; Radford, David C. [ORNL Physics Div.

2013-12-30

Highly segmented, position-sensitive germanium detector systems are being developed for nuclear physics research where traditional electronic signal processing with mixed analog and digital function blocks would be enormously complex and costly. Future systems will be constructed using pipelined processing of high-speed digitized signals as is done in the telecommunications industry. Techniques which provide rapid algorithm and system development for future systems are desirable. This project has used digital signal processing concepts and existing graphical system design tools to develop a set of re-usable modular functions and libraries targeted for the nuclear physics community. Researchers working with complex nuclear detector arrays such as the Gamma-Ray Energy Tracking Array (GRETA) have been able to construct advanced data processing algorithms for implementation in field programmable gate arrays (FPGAs) through application of these library functions using intuitive graphical interfaces.

Vacuum status-display and sector-conditioning programs

International Nuclear Information System (INIS)

Skelly, J.; Yen, S.

1989-01-01

Two programs have been developed for observation and control of the AGS vacuum system, which include these notable features: they incorporate a graphical user interface, and they are driven by a relational database which describes the vacuum system. The vacuum system comprises some 440 devices organized into 28 vacuum sectors. The Status Display Program invites menu selection of a sector, interrogates the relational database for relevant vacuum devices, acquires live readbacks, and posts a graphical display of their status. The Sector Conditioning Program likewise invites sector selection, produces the same status display, and also implements process control logic on the sector devices to pump the sector down from atmospheric pressure to high vacuum over a period extending for several hours. As additional devices are installed in the vacuum system, the devices are likewise added to the relational database; these programs then automatically include the new devices. 2 refs., 1 fig

Evolution of phage display technology: from discovery to application.

Science.gov (United States)

Rahbarnia, Leila; Farajnia, Safar; Babaei, Hossein; Majidi, Jafar; Veisi, Kamal; Ahmadzadeh, Vahideh; Akbari, Bahman

2017-03-01

Phage display technology as a selection-based system is an attractive method for evolution of new biological drugs. Unique ability of phage libraries for displaying proteins on bacteriophage surfaces enable them to make a major contribution in diverse fields of researches related to the diagnosis and therapy of diseases. One of the great challenges facing researchers is the modification of phage display technology and the development of new applications. This article reviews the molecular basis of phage display library, and summarizes the novel and specific applications of this technique in the field of biological drugs development including therapeutic antibodies, peptides, vaccines, and catalytic antibodies.

Application Reuse Library for Software, Requirements, and Guidelines

Science.gov (United States)

Malin, Jane T.; Thronesbery, Carroll

1994-01-01

Better designs are needed for expert systems and other operations automation software, for more reliable, usable and effective human support. A prototype computer-aided Application Reuse Library shows feasibility of supporting concurrent development and improvement of advanced software by users, analysts, software developers, and human-computer interaction experts. Such a library expedites development of quality software, by providing working, documented examples, which support understanding, modification and reuse of requirements as well as code. It explicitly documents and implicitly embodies design guidelines, standards and conventions. The Application Reuse Library provides application modules with Demo-and-Tester elements. Developers and users can evaluate applicability of a library module and test modifications, by running it interactively. Sub-modules provide application code and displays and controls. The library supports software modification and reuse, by providing alternative versions of application and display functionality. Information about human support and display requirements is provided, so that modifications will conform to guidelines. The library supports entry of new application modules from developers throughout an organization. Example library modules include a timer, some buttons and special fonts, and a real-time data interface program. The library prototype is implemented in the object-oriented G2 environment for developing real-time expert systems.

Ribosome display: next-generation display technologies for production of antibodies in vitro.

Science.gov (United States)

He, Mingyue; Khan, Farid

2005-06-01

Antibodies represent an important and growing class of biologic research reagents and biopharmaceutical products. They can be used as therapeutics in a variety of diseases. With the rapid expansion of proteomic studies and biomarker discovery, there is a need for the generation of highly specific binding reagents to study the vast number of proteins encoded by the genome. Display technologies provide powerful tools for obtaining antibodies. Aside from the preservation of natural antibody repertoires, they are capable of exploiting diversity by DNA recombination to create very large libraries for selection of novel molecules. In contrast to in vivo immunization processes, display technologies allow selection of antibodies under in vitro-defined selection condition(s), resulting in enrichment of antibodies with desired properties from large populations. In addition, in vitro selection enables the isolation of antibodies against difficult antigens including self-antigens, and this can be applied to the generation of human antibodies against human targets. Display technologies can also be combined with DNA mutagenesis for antibody evolution in vitro. Some methods are amenable to automation, permitting high-throughput generation of antibodies. Ribosome display is considered as representative of the next generation of display technologies since it overcomes the limitations of cell-based display methods by using a cell-free system, offering advantages of screening larger libraries and continuously expanding new diversity during selection. Production of display-derived antibodies can be achieved by choosing one of a variety of prokaryotic and eukaryotic cell-based expression systems. In the near future, cell-free protein synthesis may be developed as an alternative for large-scale generation of antibodies.

System Would Generate Virtual Heads-Up Display

Science.gov (United States)

Lambert, James L.

1994-01-01

Proposed helmet-mounted electronic display system superimposes full-color alphanumerical and/or graphical information onto observer's visual field. Displayed information projected directly onto observer's retinas, giving observer illusion of full-size computer display in foreground or background. Display stereoscopic, holographic, or in form of virtual image. Used by pilots to view navigational information while looking outside or at instruments, by security officers to view information about critical facilities while looking at visitors, or possibly even stock-exchange facilities to view desktop monitors and overhead displays simultaneously. System includes acousto-optical tunable filter (AOTF), which acts as both spectral filter and spatial light modulator.

Conventions for reporting and displaying overflight observations

International Nuclear Information System (INIS)

McFarland, B.; Murphy, J.; Simecek-Beatty, D.

1993-01-01

During the critical initial phases of an oil spill response, as observations and reports come in from different agencies and companies, descriptions and representations can vary widely. These apparently conflicting reports can cause unnecessary confusion, wasting valuable time and resources. As the number of open-quotes expertsclose quotes and the amount of open-quotes necessaryclose quotes information multiply, the potential for information overload also increases. Important information that needs to be presented can be lost in the flood of information that is available. For many years the National Oceanic and Atmospheric Administration (NOAA), in support of the US Coast Guard, has coordinated scientific input concerning the tracking and prediction of the transport of oil spilled in the marine environment. This role frequently involves recording visual or remote sensing observations from multiple platforms and observers, and displaying the information in a clear format, which needs to be rapidly available and unambiguous. Simple graphic products help identify conflicting views of information and allow responders to quickly build a open-quotes graphic consensusclose quotes of the situation. To this end the authors have developed in-house guidelines for presentation of crucial response information. Because correctly designed graphics can clearly and rapidly transmit large amounts of information, these guidelines focus on the graphic presentation of information. Some of these same conventions and criteria are being applied in evaluating and developing information acquisition and display tools. This poster presentation includes examples of the hardware and software used by Genwest and NOAA for the rapid display of response information

Pictorial Visual Rotation Ability of Engineering Design Graphics Students

Science.gov (United States)

Ernst, Jeremy Vaughn; Lane, Diarmaid; Clark, Aaron C.

2015-01-01

The ability to rotate visual mental images is a complex cognitive skill. It requires the building of graphical libraries of information through short or long term memory systems and the subsequent retrieval and manipulation of these towards a specified goal. The development of mental rotation skill is of critical importance within engineering…

Novel ZnO-binding peptides obtained by the screening of a phage display peptide library

Energy Technology Data Exchange (ETDEWEB)

Golec, Piotr [Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Laboratory of Molecular Biology (affiliated with the University of Gdansk) (Poland); Karczewska-Golec, Joanna [University of Gdansk and Medical University of Gdansk, Laboratory of Molecular Bacteriology, Intercollegiate Faculty of Biotechnology (Poland); Los, Marcin; Wegrzyn, Grzegorz, E-mail: wegrzyn@biotech.univ.gda.pl [University of Gdansk, Department of Molecular Biology (Poland)

2012-11-15

Zinc oxide (ZnO) is a semiconductor compound with a potential for wide use in various applications, including biomaterials and biosensors, particularly as nanoparticles (the size range of ZnO nanoparticles is from 2 to 100 nm, with an average of about 35 nm). Here, we report isolation of novel ZnO-binding peptides, by screening of a phage display library. Interestingly, amino acid sequences of the ZnO-binding peptides reported in this paper and those described previously are significantly different. This suggests that there is a high variability in sequences of peptides which can bind particular inorganic molecules, indicating that different approaches may lead to discovery of different peptides of generally the same activity (e.g., binding of ZnO) but having various detailed properties, perhaps crucial under specific conditions of different applications.

NGLview-interactive molecular graphics for Jupyter notebooks.

Science.gov (United States)

Nguyen, Hai; Case, David A; Rose, Alexander S

2018-04-01

NGLview is a Jupyter/IPython widget to interactively view molecular structures as well as trajectories from molecular dynamics simulations. Fast and scalable molecular graphics are provided through the NGL Viewer. The widget supports showing data from the file-system, online data bases and from objects of many popular analysis libraries including mdanalysis, mdtraj, pytraj, rdkit and more. The source code is freely available under the MIT license at https://github.com/arose/nglview. Python packages are available from PyPI and bioconda. NGLview uses Python on the server-side and JavaScript on the client. The integration with Jupyter is done through the ipywidgets package. The NGL Viewer is embedded client-side to provide WebGL accelerated molecular graphics. asr.moin@gmail.com.

Construction of High-Quality Camel Immune Antibody Libraries.

Science.gov (United States)

Romão, Ema; Poignavent, Vianney; Vincke, Cécile; Ritzenthaler, Christophe; Muyldermans, Serge; Monsion, Baptiste

2018-01-01

Single-domain antibodies libraries of heavy-chain only immunoglobulins from camelids or shark are enriched for high-affinity antigen-specific binders by a short in vivo immunization. Thus, potent binders are readily retrieved from relatively small-sized libraries of 10 7 -10 8 individual transformants, mostly after phage display and panning on a purified target. However, the remaining drawback of this strategy arises from the need to generate a dedicated library, for nearly every envisaged target. Therefore, all the procedures that shorten and facilitate the construction of an immune library of best possible quality are definitely a step forward. In this chapter, we provide the protocol to generate a high-quality immune VHH library using the Golden Gate Cloning strategy employing an adapted phage display vector where a lethal ccdB gene has to be substituted by the VHH gene. With this procedure, the construction of the library can be shortened to less than a week starting from bleeding the animal. Our libraries exceed 10 8 individual transformants and close to 100% of the clones harbor a phage display vector having an insert with the length of a VHH gene. These libraries are also more economic to make than previous standard approaches using classical restriction enzymes and ligations. The quality of the Nanobodies that are retrieved from immune libraries obtained by Golden Gate Cloning is identical to those from immune libraries made according to the classical procedure.

enforcing tertiary school library rules and regulations

African Journals Online (AJOL)

2014-10-31

Oct 31, 2014 ... beings -library users/patrons. It is also a standard rule that library ... degree of criminal behaviors in the use of their resources (Momodu, 2002). It is also a well known fact that some individual users of academic libraries display disruptive or criminal behaviors within the library and this often poses security ...

Performance-based evaluation of graphic displays for nuclear-power-plant control rooms

International Nuclear Information System (INIS)

Petersen, R.J.; Banks, W.W.; Gertman, D.I.

1982-01-01

This paper reports several methodologies for evaluating the perceptual and perceptual/decision making aspects of displays used in the control rooms of nuclear power plants. This NRC funded study focuses upon the Safety Parameter Display System (SPDS) and relates the utility of the display to objective performance and preference measures obtained in experimental conditions. The first condition is a traditional laboratory setting where classical experimental methodologies can be employed. The second condition is an interactive control room simulation where the operator's performance is assessed while he/she operates the simulator. The third condition is a rating scale designed to assess operator preferences and opinions regarding a variety of display formats. The goal of this study is the development of a cost-efficient display evaluation methodology which correlates highly with the operator's ability to control a plant

Distinctive Expertise: Multimedia, the Library, and the Term Paper of the Future

Directory of Open Access Journals (Sweden)

Gregory A. Mitchell

2005-03-01

Full Text Available Multimedia will have a profound effect on libraries duringthe next decade. This rapidly developing technology permits the user to combine digital still images, video, animation, graphics, and audio. It can be delivered in a variety offinished formats, including streaming video on the Web,video on DVD/VCD, embedded digital objects within aWeb page or presentation software such as PowerPoint,utilized within graphic designs, or printed as hardcopy.This article examines the elements of multimedia creation,as well as requirements and recommendations for implementing a multimedia facility in the library.

Heterogeneous Multicore Parallel Programming for Graphics Processing Units

Directory of Open Access Journals (Sweden)

Francois Bodin

2009-01-01

Full Text Available Hybrid parallel multicore architectures based on graphics processing units (GPUs can provide tremendous computing power. Current NVIDIA and AMD Graphics Product Group hardware display a peak performance of hundreds of gigaflops. However, exploiting GPUs from existing applications is a difficult task that requires non-portable rewriting of the code. In this paper, we present HMPP, a Heterogeneous Multicore Parallel Programming workbench with compilers, developed by CAPS entreprise, that allows the integration of heterogeneous hardware accelerators in a unintrusive manner while preserving the legacy code.

Instrumentation for on-line mountain range displays

International Nuclear Information System (INIS)

van Asselt, W.K.; Ahrens, L.A.

1994-01-01

A method to obtain and process 'mountain range' displays of beam signals is described. A custom-made trigger generator and a digital oscilloscope are used for the data acquisition and the graphical interface package LabVIEW is used to process the data. High resolution displays of wall monitor signals updating every AGS cycle have proven very powerful as a beam diagnostic

Graphical interface for PPDS system based on PAW

International Nuclear Information System (INIS)

Ivanov, V.V.; Stolyarskij, Yu.V.

1992-01-01

The program interface allowing to display graphically experimental measurements results and evaluations of various physical reactions parameters stored in the REACTIONS database of PPDS system is described. PAW package is used for experimental data visualization. 7 refs.; 2 figs.; 3 tabs

Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro

Directory of Open Access Journals (Sweden)

Renata Rosito Tonelli

2013-01-01

Full Text Available Parasite infections are largely dependent on interactions between pathogen and different host cell populations to guarantee a successful infectious process. This is particularly true for obligatory intracellular parasites as Plasmodium, Toxoplasma, Leishmania, to name a few. Adhesion to and entry into the cell are essential steps requiring specific parasite and host cell molecules. The large amount of possible involved molecules poses additional difficulties for their identification by the classical biochemical approaches. In this respect, the search for alternative techniques should be pursued. Among them two powerful methodologies can be employed, both relying upon the construction of highly diverse combinatorial libraries of peptides or oligonucleotides that randomly bind with high affinity to targets on the cell surface and are selectively displaced by putative ligands. These are, respectively, the peptide-based phage display and the oligonucleotide-based aptamer techniques.The phage display technique has been extensively employed for the identification of novel ligands in vitro and in vivo in different areas such as cancer, vaccine development and epitope mapping. Particularly, phage display has been employed in the investigation of pathogen-host interactions. Although this methodology has been used for some parasites with encouraging results, in trypanosomatids its use is, as yet, scanty. RNA and DNA aptamers, developed by the SELEX process (Systematic Evolution of Ligands by Exponential Enrichment, were described over two decades ago and since then contributed to a large number of structured nucleic acids for diagnostic or therapeutic purposes or for the understanding of the cell biology. Similarly to the phage display technique scarce use of the SELEX process has been used in the probing of parasite-host interaction.In this review, an overall survey on the use of both phage display and aptamer technologies in different pathogenic

SearchSmallRNA: a graphical interface tool for the assemblage of viral genomes using small RNA libraries data.

Science.gov (United States)

de Andrade, Roberto R S; Vaslin, Maite F S

2014-03-07

Next-generation parallel sequencing (NGS) allows the identification of viral pathogens by sequencing the small RNAs of infected hosts. Thus, viral genomes may be assembled from host immune response products without prior virus enrichment, amplification or purification. However, mapping of the vast information obtained presents a bioinformatics challenge. In order to by pass the need of line command and basic bioinformatics knowledge, we develop a mapping software with a graphical interface to the assemblage of viral genomes from small RNA dataset obtained by NGS. SearchSmallRNA was developed in JAVA language version 7 using NetBeans IDE 7.1 software. The program also allows the analysis of the viral small interfering RNAs (vsRNAs) profile; providing an overview of the size distribution and other features of the vsRNAs produced in infected cells. The program performs comparisons between each read sequenced present in a library and a chosen reference genome. Reads showing Hamming distances smaller or equal to an allowed mismatched will be selected as positives and used to the assemblage of a long nucleotide genome sequence. In order to validate the software, distinct analysis using NGS dataset obtained from HIV and two plant viruses were used to reconstruct viral whole genomes. SearchSmallRNA program was able to reconstructed viral genomes using NGS of small RNA dataset with high degree of reliability so it will be a valuable tool for viruses sequencing and discovery. It is accessible and free to all research communities and has the advantage to have an easy-to-use graphical interface. SearchSmallRNA was written in Java and is freely available at http://www.microbiologia.ufrj.br/ssrna/.

New displaying models of bibliographic data and resources: cataloguing/resource description and search results

Directory of Open Access Journals (Sweden)

Antonella Trombone

2014-05-01

The paper here proposed analyzes different patterns of bibliographic data visualization that libraries’ OPACs and library service platforms begin to offer, focusing on three categories of innovations in displaying of cataloguing data: the data proposed by discovery tools or library service platforms, that transform and integrate information taken from the Integrated Library Systems with other collections accessible through libraries; the data derived from the cataloguing based on RDA started in some libraries; the displays of bibliographic data emulating the hierarchical organization among entities foreseen by FRBR.

The missing graphical user interface for genomics.

Science.gov (United States)

Schatz, Michael C

2010-01-01

The Galaxy package empowers regular users to perform rich DNA sequence analysis through a much-needed and user-friendly graphical web interface. See research article http://genomebiology.com/2010/11/8/R86 RESEARCH HIGHLIGHT: With the advent of affordable and high-throughput DNA sequencing, sequencing is becoming an essential component in nearly every genetics lab. These data are being generated to probe sequence variations, to understand transcribed, regulated or methylated DNA elements, and to explore a host of other biological features across the tree of life and across a range of environments and conditions. Given this deluge of data, novices and experts alike are facing the daunting challenge of trying to analyze the raw sequence data computationally. With so many tools available and so many assays to analyze, how can one be expected to stay current with the state of the art? How can one be expected to learn to use each tool and construct robust end-to-end analysis pipelines, all while ensuring that input formats, command-line options, sequence databases and program libraries are set correctly? Finally, once the analysis is complete, how does one ensure the results are reproducible and transparent for others to scrutinize and study?In an article published in Genome Biology, Jeremy Goecks, Anton Nekrutenko, James Taylor and the rest of the Galaxy Team (Goecks et al. 1) make a great advance towards resolving these critical questions with the latest update to their Galaxy Project. The ambitious goal of Galaxy is to empower regular users to carry out their own computational analysis without having to be an expert in computational biology or computer science. Galaxy adds a desperately needed graphical user interface to genomics research, making data analysis universally accessible in a web browser, and freeing users from the minutiae of archaic command-line parameters, data formats and scripting languages. Data inputs and computational steps are selected from

Computation of large covariance matrices by SAMMY on graphical processing units and multicore CPUs

International Nuclear Information System (INIS)

Arbanas, G.; Dunn, M.E.; Wiarda, D.

2011-01-01

Computational power of Graphical Processing Units and multicore CPUs was harnessed by the nuclear data evaluation code SAMMY to speed up computations of large Resonance Parameter Covariance Matrices (RPCMs). This was accomplished by linking SAMMY to vendor-optimized implementations of the matrix-matrix multiplication subroutine of the Basic Linear Algebra Library to compute the most time-consuming step. The 235 U RPCM computed previously using a triple-nested loop was re-computed using the NVIDIA implementation of the subroutine on a single Tesla Fermi Graphical Processing Unit, and also using the Intel's Math Kernel Library implementation on two different multicore CPU systems. A multiplication of two matrices of dimensions 16,000×20,000 that had previously taken days, took approximately one minute on the GPU. Comparable performance was achieved on a dual six-core CPU system. The magnitude of the speed-up suggests that these, or similar, combinations of hardware and libraries may be useful for large matrix operations in SAMMY. Uniform interfaces of standard linear algebra libraries make them a promising candidate for a programming framework of a new generation of SAMMY for the emerging heterogeneous computing platforms. (author)

Computation of large covariance matrices by SAMMY on graphical processing units and multicore CPUs

Energy Technology Data Exchange (ETDEWEB)

Arbanas, G.; Dunn, M.E.; Wiarda, D., E-mail: arbanasg@ornl.gov, E-mail: dunnme@ornl.gov, E-mail: wiardada@ornl.gov [Oak Ridge National Laboratory, Oak Ridge, TN (United States)

2011-07-01

Computational power of Graphical Processing Units and multicore CPUs was harnessed by the nuclear data evaluation code SAMMY to speed up computations of large Resonance Parameter Covariance Matrices (RPCMs). This was accomplished by linking SAMMY to vendor-optimized implementations of the matrix-matrix multiplication subroutine of the Basic Linear Algebra Library to compute the most time-consuming step. The {sup 235}U RPCM computed previously using a triple-nested loop was re-computed using the NVIDIA implementation of the subroutine on a single Tesla Fermi Graphical Processing Unit, and also using the Intel's Math Kernel Library implementation on two different multicore CPU systems. A multiplication of two matrices of dimensions 16,000×20,000 that had previously taken days, took approximately one minute on the GPU. Comparable performance was achieved on a dual six-core CPU system. The magnitude of the speed-up suggests that these, or similar, combinations of hardware and libraries may be useful for large matrix operations in SAMMY. Uniform interfaces of standard linear algebra libraries make them a promising candidate for a programming framework of a new generation of SAMMY for the emerging heterogeneous computing platforms. (author)

Construction of a T7 Human Lung Cancer cDNA Library

Directory of Open Access Journals (Sweden)

Wentao YUE

2008-10-01

Full Text Available Background and objective Currently, only a limited numbers of tumor markers for non small lung cancer (NSCLC diagnosis, new biomarker, such as serum autoantibody may improve the early detection of lung cancer. Our objective is construction human lung squamous carcinoma and adenocarcinoma T7 phage display cDNA library from the tissues of NSCLC patients. Methods mRNA was isolated from a pool of total RNA extract from NSCLC tissues obtained from 5 adenocarcinomas and 5 squamous carcinomas, and then mRNA was reverse transcribed into double stranded cDNA. After digestion, the cDNA was inserted into T7Select 10-3 vector. The phage display cDNA library was constructed by package reaction in vitro and plate proliferation. Plaque assay and PCR were used to evaluate the library.Results Two T7 phage display cDNA library were established. Plaque assay show the titer of lung squamas carcinoma library was 1.8×106 pfu, and the adenocarcinoma library was 5×106 pfu. The phage titer of the amplified library were 3.2×1010 pfu/mL and 2.5×1010 pfu/mL. PCR amplification of random plaque show insert ratio were 100% (24/24 in adenocarcinoma library and 95.8% in human lung squamas carcinoma library (23/24. Insert range from 300 bp to 1 500 bp. Conclusion Two phage display cDNA library from NSCLC were constructed.

Software Graphics Processing Unit (sGPU) for Deep Space Applications

Science.gov (United States)

McCabe, Mary; Salazar, George; Steele, Glen

2015-01-01

A graphics processing capability will be required for deep space missions and must include a range of applications, from safety-critical vehicle health status to telemedicine for crew health. However, preliminary radiation testing of commercial graphics processing cards suggest they cannot operate in the deep space radiation environment. Investigation into an Software Graphics Processing Unit (sGPU)comprised of commercial-equivalent radiation hardened/tolerant single board computers, field programmable gate arrays, and safety-critical display software shows promising results. Preliminary performance of approximately 30 frames per second (FPS) has been achieved. Use of multi-core processors may provide a significant increase in performance.

Viewing MORSE-CG radiation transport with 3-D color graphics

International Nuclear Information System (INIS)

Namito, Yoshihito; Jenkins, T.M.; Nelson, W.R.

1990-01-01

In this paper we present the coupling of MORSE-CG with the SLAC Unified Graphics System (UGS77) through an add-on package called MORSGRAF which allows for real-time display of neutron and photon tracks in the Monte Carlo simulation. In addition to displaying the myriad of complicated geometries that can be created with the MORSE Combinatorial Geometry program, MORSGRAF permits color tagging of neutrons (green) and photons (red) with the variation of track intensity an indicator of the energy of the particle. Particle types can be switched off and on by means of a mouse-icon system, and the perspective can be changed (i.e., rotated, translated, and zoomed). MORSGRAF also allows one to display the propagation of radiation through shields and mazes on an ordinary graphics terminal, as well as in documents printed on a laser printer. Several examples will be given to demonstrate the various capabilities of MORSGRAF coupled to MORSE-CG. 12 refs., 8 figs

Old Books Bring New Life to the Brick and Mortar Library

Science.gov (United States)

Bosken, S.

2012-08-01

If all the library books and journals can be viewed on your desk top, why come to the physical library? The USNO Library tried to bring the patrons inside the library. One method was to rotate rare book displays each month. As the library holds a fabulous collection of ancient astronomy books, including Copernicus, Kepler, Galileo, and Newton, we have abundant resources. The presentation will highlight the varied displays and offer a Rare Books 101 explanation of paper, printing, binding and a behind-the-scenes look at how old books are maintained and preserved.

Meaningful Real-Time Graphics Workstation Performance Measurements

Science.gov (United States)

1988-11-01

alike can effectively operate the program with little or no help from user’s manuals or other users. A thorough and efficient design of command line...Specifica- tions, San Jose, California, 1988. 4. Apgar , Brian, Bersack, Bret and Mammen, Abraham, "A Display System for the Stellarr m Graphics

Affinity selection of Nipah and Hendra virus-related vaccine candidates from a complex random peptide library displayed on bacteriophage virus-like particles

Energy Technology Data Exchange (ETDEWEB)

Peabody, David S.; Chackerian, Bryce; Ashley, Carlee; Carnes, Eric; Negrete, Oscar

2017-01-24

The invention relates to virus-like particles of bacteriophage MS2 (MS2 VLPs) displaying peptide epitopes or peptide mimics of epitopes of Nipah Virus envelope glycoprotein that elicit an immune response against Nipah Virus upon vaccination of humans or animals. Affinity selection on Nipah Virus-neutralizing monoclonal antibodies using random sequence peptide libraries on MS2 VLPs selected peptides with sequence similarity to peptide sequences found within the envelope glycoprotein of Nipah itself, thus identifying the epitopes the antibodies recognize. The selected peptide sequences themselves are not necessarily identical in all respects to a sequence within Nipah Virus glycoprotein, and therefore may be referred to as epitope mimics VLPs displaying these epitope mimics can serve as vaccine. On the other hand, display of the corresponding wild-type sequence derived from Nipah Virus and corresponding to the epitope mapped by affinity selection, may also be used as a vaccine.

WIRED 4 - A Generic Event Display Plugin for JAS 3

International Nuclear Information System (INIS)

Donszelmann, M.

2004-01-01

WIRED 4 is an experiment independent event display plugin module for the JAS 3 (Java Analysis Studio) generic analysis framework. Both WIRED and JAS are written in Java. WIRED, which uses HepRep (HEP Representables for Event Display) as its input format, supports viewing of events using either conventional 3D projections as well as specialized projections, such as a fish-eye or a ρ-Z projection. Projections allow the user to scale, rotate, position or change parameters on the plot as he wishes. All interactions are handled as separate edits which can be undone and/or redone, so the user can try out things and get back to a previous situation. All edits are scriptable by any of the scripting languages supported by JAS, such as pnuts, jython or java itself. Hits and tracks can be picked to display physics information and cuts can be made on physics parameters to allow the user to filter the number of objects drawn into the plot. Multiple event display plots can be laid out on pages combined with histograms and other plots, available from JAS itself or from other plugin modules. Configuration information on the state of all plots can be saved and restored allowing the user to save his session, share it with others or later continue where he left off. This version of WIRED is written to be easily extensible by the user/developer. Projections, representations, interaction handlers and edits are all services and new ones can be added by writing additional plugins. Both JAS 3 and WIRED 4 are built on top of the FreeHEP Java Libraries, which support a multitude of vector graphics output formats, such as PostScript, PDF, SVG, SWF and EMF, allowing document quality output of event display plots and histograms

TRIGLAV-W a Windows computer program package with graphical users interface for TRIGA reactor core management calculations

International Nuclear Information System (INIS)

Zagar, T.; Zefran, B.; Slavic, S.; Snoj, L.; Ravnik, M.

2006-01-01

TRIGLAV-W is a program package for reactor calculations of TRIGA Mark II research reactor cores. This program package runs under Microsoft Windows operating system and has new friendly graphical user interface (GUI). The main part of the package is the TRIGLAV code based on two dimensional diffusion approximation for flux distribution calculation. The new GUI helps the user to prepare the input files, runs the main code and displays the output files. TRIGLAV-W has a user friendly GUI also for the visualisation of the calculation results. Calculation results can be visualised using 2D and 3D coloured graphs for easy presentations and analysis. In the paper the many options of the new GUI are presented along with the results of extensive testing of the program. The results of the TRIGLAV-W program package were compared with the results of WIMS-D and MCNP code for calculations of TRIGA benchmark. TRIGLAV-W program was also tested using several libraries developed under IAEA WIMS-D Library Update Project. Additional literature and application form for TRIGLAV-W program package beta testing can be found at http://www.rcp.ijs.si/triglav/. (author)

InfoGallery: Informative Arts Services for Physical Library Spaces

DEFF Research Database (Denmark)

Grønbæk, Kaj; Rohde, Anne; Sundararajah, Balasuthas

2006-01-01

Much focus in digital libraries research has been devoted to new online services rather than services for the visitors in the physical library. This paper describes InfoGallery, which is a web-based infrastructure for enriching the physical library space with informative art "exhibitions......" of digital library material and other relevant information, such as RSS news streams, event announcements etc. InfoGallery presents information in an aesthetically attractive manner on a variety of surfaces in the library, including cylindrical displays and floors. The infrastructure consists of a server...... structure, an editor application and a variety of display clients. The paper discusses the design of the infrastructure and its utilization of RSS, podcasts and manually edited news. Applications in the library domain are described and the experiences are discussed....

IMAGE information monitoring and applied graphics software environment. Volume 2. Software description

International Nuclear Information System (INIS)

Hallam, J.W.; Ng, K.B.; Upham, G.L.

1986-09-01

The EPRI Information Monitoring and Applied Graphics Environment (IMAGE) system is designed for 'fast proto-typing' of advanced concepts for computer-aided plant operations tools. It is a flexible software system which can be used for rapidly creating, dynamically driving and evaluating advanced operator aid displays. The software is written to be both host computer and graphic device independent

A universal phage display system for the seamless construction of Fab libraries.

Science.gov (United States)

Nelson, Renae S; Valadon, Philippe

2017-11-01

The construction of Fab phage libraries requires the cloning of domains from both the light and the heavy chain of antibodies. Despite the advent of powerful strategies such as splicing-by-overlap extension PCR, obtaining high quality libraries with excellent coverage remains challenging. Here, we explored the use of type IIS restriction enzymes for the seamless cloning of Fab libraries. We analyzed human, murine and rabbit germline antibody repertoires and identified combinations of restriction enzymes that exhibit very few or no recognition sites in the antibody sequences. We describe three phagemid vectors, pUP-22Hb, pUP-22Mc and pUP-22Rc, which were employed for cloning the Fab repertoire of these hosts using BsmBI and SapI (human) or SapI alone (mouse and rabbit). Using human serum albumin as a model immunization, we built a mouse/human chimeric Fab library and a mouse Fab library in a single step ligation and successfully panned multiple cognate antibodies. The overall process is highly scalable and faster than PCR-based techniques, with a Fab insertion success rate of around 80%. By using carefully chosen overhangs on each end of the antibody domains, this approach paves the way to the universal, sequence- and vector-independent cloning and reformatting of antibody libraries. Copyright © 2017 Elsevier B.V. All rights reserved.

Combining Phage and Yeast Cell Surface Antibody Display to Identify Novel Cell Type-Selective Internalizing Human Monoclonal Antibodies.

Science.gov (United States)

Bidlingmaier, Scott; Su, Yang; Liu, Bin

2015-01-01

Using phage antibody display, large libraries can be generated and screened to identify monoclonal antibodies with affinity for target antigens. However, while library size and diversity is an advantage of the phage display method, there is limited ability to quantitatively enrich for specific binding properties such as affinity. One way of overcoming this limitation is to combine the scale of phage display selections with the flexibility and quantitativeness of FACS-based yeast surface display selections. In this chapter we describe protocols for generating yeast surface antibody display libraries using phage antibody display selection outputs as starting material and FACS-based enrichment of target antigen-binding clones from these libraries. These methods should be widely applicable for the identification of monoclonal antibodies with specific binding properties.

Spatial issues in user interface design from a graphic design perspective

Science.gov (United States)

Marcus, Aaron

1989-01-01

The user interface of a computer system is a visual display that provides information about the status of operations on data within the computer and control options to the user that enable adjustments to these operations. From the very beginning of computer technology the user interface was a spatial display, although its spatial features were not necessarily complex or explicitly recognized by the users. All text and nonverbal signs appeared in a virtual space generally thought of as a single flat plane of symbols. Current technology of high performance workstations permits any element of the display to appear as dynamic, multicolor, 3-D signs in a virtual 3-D space. The complexity of appearance and the user's interaction with the display provide significant challenges to the graphic designer of current and future user interfaces. In particular, spatial depiction provides many opportunities for effective communication of objects, structures, processes, navigation, selection, and manipulation. Issues are presented that are relevant to the graphic designer seeking to optimize the user interface's spatial attributes for effective visual communication.

Theory and practice of Auto CAD, computer graphics

International Nuclear Information System (INIS)

Hwang, Si Won; Choe, Hong Yeong; Shin, Jae Yeon; Lee, Ryong Cheol

1990-08-01

This book describes theory and practice of Auto CAD, computer graphics, which deals with peripheral of computer, occurrence of digital line by DDA, BRM, theory of conversion, data base and display and shape modeling. This book gives descriptions of outline of CAD system, Auto CAD, basic function practice, simple figure practice, the third angle projection drawing a little complex single object, machine drawing I, function practice of improved Auto CAD, edit, set up layer, and 3D, and 3D display function.

Drag and drop display & builder

Energy Technology Data Exchange (ETDEWEB)

Bolshakov, Timofei B.; Petrov, Andrey D.; /Fermilab

2007-12-01

The Drag and Drop (DnD) Display & Builder is a component-oriented system that allows users to create visual representations of data received from data acquisition systems. It is an upgrade of a Synoptic Display mechanism used at Fermilab since 2002. Components can be graphically arranged and logically interconnected in the web-startable Project Builder. Projects can be either lightweight AJAX- and SVG-based web pages, or they can be started as Java applications. The new version was initiated as a response to discussions between the LHC Controls Group and Fermilab.

Development of a T7 Phage Display Library to Detect Sarcoidosis and Tuberculosis by a Panel of Novel Antigens

Directory of Open Access Journals (Sweden)

Harvinder Talwar

2015-04-01

Full Text Available Sarcoidosis is a granulomatous inflammatory disease, diagnosed through tissue biopsy of involved organs in the absence of other causes such as tuberculosis (TB. No specific serologic test is available to diagnose and differentiate sarcoidosis from TB. Using a high throughput method, we developed a T7 phage display cDNA library derived from mRNA isolated from bronchoalveolar lavage (BAL cells and leukocytes of sarcoidosis patients. This complex cDNA library was biopanned to obtain 1152 potential sarcoidosis antigens and a microarray was constructed to immunoscreen two different sets of sera from healthy controls and sarcoidosis. Meta-analysis identified 259 discriminating sarcoidosis antigens, and multivariate analysis identified 32 antigens with a sensitivity of 89% and a specificity of 83% to classify sarcoidosis from healthy controls. Additionally, interrogating the same microarray platform with sera from subjects with TB, we identified 50 clones that distinguish between TB, sarcoidosis and healthy controls. The top 10 sarcoidosis and TB specific clones were sequenced and homologies were searched in the public database revealing unique epitopes and mimotopes in each group. Here, we show for the first time that immunoscreenings of a library derived from sarcoidosis tissue differentiates between sarcoidosis and tuberculosis antigens. These novel biomarkers can improve diagnosis of sarcoidosis and TB, and may aid to develop or evaluate a TB vaccine.

Bridging the Gaps: Measuring Cultural Competence among Future School Library and Youth Services Library Professionals

Science.gov (United States)

Hill, Renee Franklin; Kumasi, Kafi

2011-01-01

School library and youth services professionals must develop and display a strong sense of cultural competence to effectively serve their patrons. Cultural competence is defined here as one's ability to understand the needs of populations different from their own. This paper reports on the perceptions of school library and youth services students…

An anti-tumor protein produced by Trichinella spiralis and identified by screening a T7 phage display library, induces apoptosis in human hepatoma H7402 cells

Science.gov (United States)

Trichinella spiralis infection confers effective resistance to tumor cell expansion. In this study, a T7 phage cDNA display library was constructed to express genes encoded by T. spiralis. Organic phase multi-cell screening was used to sort through candidate proteins in a transfected human chronic m...

A course in constructing effective displays of data for pharmaceutical research personnel.

Science.gov (United States)

Bradstreet, Thomas E; Nessly, Michael L; Short, Thomas H

2013-01-01

Interpreting data and communicating effectively through graphs and tables are requisite skills for statisticians and non-statisticians in the pharmaceutical industry. However, the quality of visual displays of data in the medical and pharmaceutical literature and at scientific conferences is severely lacking. We describe an interactive, workshop-driven, 2-day short course that we constructed for pharmaceutical research personnel to learn these skills. The examples in the course and the workshop datasets source from our professional experiences, the scientific literature, and the mass media. During the course, the participants are exposed to and gain hands-on experience with the principles of visual and graphical perception, design, and construction of both graphic and tabular displays of quantitative and qualitative information. After completing the course, with a critical eye, the participants are able to construct, revise, critique, and interpret graphic and tabular displays according to an extensive set of guidelines. Copyright © 2013 John Wiley & Sons, Ltd.

Sequence Similarity Presenter: a tool for the graphic display of similarities of long sequences for use in presentations.

Science.gov (United States)

Fröhlich, K U

1994-04-01

A new method for the presentation of alignments of long sequences is described. The degree of identity for the aligned sequences is averaged for sections of a fixed number of residues. The resulting values are converted to shades of gray, with white corresponding to lack of identity and black corresponding to perfect identity. A sequence alignment is represented as a bar filled with varying shades of gray. The display is compact and allows for a fast and intuitive recognition of the distribution of regions with a high similarity. It is well suited for the presentation of alignments of long sequences, e.g. of protein superfamilies, in plenary lectures. The method is implemented as a HyperCard stack for Apple Macintosh computers. Several options for the modification of the output are available (e.g. background reduction, size of the summation window, consideration of amino acid similarity, inclusion of graphic markers to indicate specific domains). The output is a PostScript file which can be printed, imported as EPS or processed further with Adobe Illustrator.

A graphics subsystem retrofit design for the bladed-disk data acquisition system. M.S. Thesis

Science.gov (United States)

Carney, R. R.

1983-01-01

A graphics subsystem retrofit design for the turbojet blade vibration data acquisition system is presented. The graphics subsystem will operate in two modes permitting the system operator to view blade vibrations on an oscilloscope type of display. The first mode is a real-time mode that displays only gross blade characteristics, such as maximum deflections and standing waves. This mode is used to aid the operator in determining when to collect detailed blade vibration data. The second mode of operation is a post-processing mode that will animate the actual blade vibrations using the detailed data collected on an earlier data collection run. The operator can vary the rate of payback to view differring characteristics of blade vibrations. The heart of the graphics subsystem is a modified version of AMD's ""super sixteen'' computer, called the graphics preprocessor computer (GPC). This computer is based on AMD's 2900 series of bit-slice components.

Knowledge-based systems and interactive graphics for reactor control using the Automated Reasoning Tool(ART) system

International Nuclear Information System (INIS)

Ragheb, M.; Clayton, B.; Davies, P.

1987-01-01

The use of Knowledge-Based systems and advanced graphic concepts are described using the Automated Reasoning Tool (ART) for a model nuclear plant system. Through the sue of asynchronous graphic input/output, the user is allowed to communicate through a graphical display to a Production-Rule Analysis System modelling the plant while its rules are actively being fired. The user changes the status of system components by pointing at them on the system configuration display with a mouse cursor and clicking one of the buttons on the mouse. The Production-Rule Analysis System accepts the new input and immediately displays its diagnosis of the system state and any associated recommendations as to the appropriate course of action. This approach offers a distinct advantage over typing the components statuses in response to queries by a conventional Production-Rule Analysis system. Moreover, two effective ways of communication between man and machine are combined

LCFM - LIVING COLOR FRAME MAKER: PC GRAPHICS GENERATION AND MANAGEMENT TOOL FOR REAL-TIME APPLICATIONS

Science.gov (United States)

Truong, L. V.

1994-01-01

Computer graphics are often applied for better understanding and interpretation of data under observation. These graphics become more complicated when animation is required during "run-time", as found in many typical modern artificial intelligence and expert systems. Living Color Frame Maker is a solution to many of these real-time graphics problems. Living Color Frame Maker (LCFM) is a graphics generation and management tool for IBM or IBM compatible personal computers. To eliminate graphics programming, the graphic designer can use LCFM to generate computer graphics frames. The graphical frames are then saved as text files, in a readable and disclosed format, which can be easily accessed and manipulated by user programs for a wide range of "real-time" visual information applications. For example, LCFM can be implemented in a frame-based expert system for visual aids in management of systems. For monitoring, diagnosis, and/or controlling purposes, circuit or systems diagrams can be brought to "life" by using designated video colors and intensities to symbolize the status of hardware components (via real-time feedback from sensors). Thus status of the system itself can be displayed. The Living Color Frame Maker is user friendly with graphical interfaces, and provides on-line help instructions. All options are executed using mouse commands and are displayed on a single menu for fast and easy operation. LCFM is written in C++ using the Borland C++ 2.0 compiler for IBM PC series computers and compatible computers running MS-DOS. The program requires a mouse and an EGA/VGA display. A minimum of 77K of RAM is also required for execution. The documentation is provided in electronic form on the distribution medium in WordPerfect format. A sample MS-DOS executable is provided on the distribution medium. The standard distribution medium for this program is one 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools

The role of the document delivery service at an evolving research library in Saudi Arabia

KAUST Repository

Vijayakumar, J.K.

2015-01-01

Design/methodology/approach – To collect the responses of document delivery service users, an online questionnaire was used with 12 multiple-choice questions and two open-ended questions. The questionnaires were sent only to the users of this service, and the responses were collected anonymously. Two surveys were conducted, in 2010 and 2013, with the same questions. The responses are displayed graphically prepared to compare the results. There were 71 responses in 2010 and 95 in 2013. Findings – In both surveys, the majority of users rated the service, staff behaviour, speed, quality, etc. with a high satisfaction level. Document delivery order statistics are a major decision-making tool, in addition to usage analysis, for developing a better, economical and highly utilized collection in brand new libraries. delivery order statistics are a major decision-making tool, in addition to usage analysis, for developing a better, economical and highly utilized collection in brand new libraries. Originality/value – This is the first published study of user perception of document delivery in Saudi Arabia.

Printing--Graphic Arts--Graphic Communications

Science.gov (United States)

Hauenstein, A. Dean

1975-01-01

Recently, "graphic arts" has shifted from printing skills to a conceptual approach of production processes. "Graphic communications" must embrace the total system of communication through graphic media, to serve broad career education purposes; students taught concepts and principles can be flexible and adaptive. The author…

Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro.

Science.gov (United States)

Tonelli, R R; Colli, W; Alves, M J M

2012-01-01

Parasite infections are largely dependent on interactions between pathogen and different host cell populations to guarantee a successful infectious process. This is particularly true for obligatory intracellular parasites as Plasmodium, Toxoplasma, and Leishmania, to name a few. Adhesion to and entry into the cell are essential steps requiring specific parasite and host cell molecules. The large amount of possible involved molecules poses additional difficulties for their identification by the classical biochemical approaches. In this respect, the search for alternative techniques should be pursued. Among them two powerful methodologies can be employed, both relying upon the construction of highly diverse combinatorial libraries of peptides or oligonucleotides that randomly bind with high affinity to targets on the cell surface and are selectively displaced by putative ligands. These are, respectively, the peptide-based phage display and the oligonucleotide-based aptamer techniques. The phage display technique has been extensively employed for the identification of novel ligands in vitro and in vivo in different areas such as cancer, vaccine development, and epitope mapping. Particularly, phage display has been employed in the investigation of pathogen-host interactions. Although this methodology has been used for some parasites with encouraging results, in trypanosomatids its use is, as yet, scanty. RNA and DNA aptamers, developed by the SELEX process (Systematic Evolution of Ligands by Exponential Enrichment), were described over two decades ago and since then contributed to a large number of structured nucleic acids for diagnostic or therapeutic purposes or for the understanding of the cell biology. Similarly to the phage display technique scarce use of the SELEX process has been used in the probing of parasite-host interaction. In this review, an overall survey on the use of both phage display and aptamer technologies in different pathogenic organisms will be

IDEA: Interactive Display for Evolutionary Analyses.

Science.gov (United States)

Egan, Amy; Mahurkar, Anup; Crabtree, Jonathan; Badger, Jonathan H; Carlton, Jane M; Silva, Joana C

2008-12-08

The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints and other molecular evolution variables of interest an increasingly important approach to addressing broad evolutionary questions. Two of the programs most widely used for this purpose are codeml and baseml, parts of the PAML (Phylogenetic Analysis by Maximum Likelihood) suite. A significant drawback of these programs is their lack of a graphical user interface, which can limit their user base and considerably reduce their efficiency. We have developed IDEA (Interactive Display for Evolutionary Analyses), an intuitive graphical input and output interface which interacts with PHYLIP for phylogeny reconstruction and with codeml and baseml for molecular evolution analyses. IDEA's graphical input and visualization interfaces eliminate the need to edit and parse text input and output files, reducing the likelihood of errors and improving processing time. Further, its interactive output display gives the user immediate access to results. Finally, IDEA can process data in parallel on a local machine or computing grid, allowing genome-wide analyses to be completed quickly. IDEA provides a graphical user interface that allows the user to follow a codeml or baseml analysis from parameter input through to the exploration of results. Novel options streamline the analysis process, and post-analysis visualization of phylogenies, evolutionary rates and selective constraint along protein sequences simplifies the interpretation of results. The integration of these functions into a single tool eliminates the need for lengthy data handling and parsing, significantly expediting access to global patterns in the data.

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries.

Science.gov (United States)

Henry, Kevin A; Kim, Dae Young; Kandalaft, Hiba; Lowden, Michael J; Yang, Qingling; Schrag, Joseph D; Hussack, Greg; MacKenzie, C Roger; Tanha, Jamshid

2017-01-01

Human autonomous V H /V L single-domain antibodies (sdAbs) are attractive therapeutic molecules, but often suffer from suboptimal stability, solubility and affinity for cognate antigens. Most commonly, human sdAbs have been isolated from in vitro display libraries constructed via synthetic randomization of rearranged V H /V L domains. Here, we describe the design and characterization of three novel human V H /V L sdAb libraries through a process of: (i) exhaustive biophysical characterization of 20 potential V H /V L sdAb library scaffolds, including assessment of expression yield, aggregation resistance, thermostability and tolerance to complementarity-determining region (CDR) substitutions; (ii) in vitro randomization of the CDRs of three V H /V L sdAb scaffolds, with tailored amino acid representation designed to promote solubility and expressibility; and (iii) systematic benchmarking of the three V H /V L libraries by panning against five model antigens. We isolated ≥1 antigen-specific human sdAb against four of five targets (13 V H s and 7 V L s in total); these were predominantly monomeric, had antigen-binding affinities ranging from 5 nM to 12 µM (average: 2-3 µM), but had highly variable expression yields (range: 0.1-19 mg/L). Despite our efforts to identify the most stable V H /V L scaffolds, selection of antigen-specific binders from these libraries was unpredictable (overall success rate for all library-target screens: ~53%) with a high attrition rate of sdAbs exhibiting false positive binding by ELISA. By analyzing V H /V L sdAb library sequence composition following selection for monomeric antibody expression (binding to protein A/L followed by amplification in bacterial cells), we found that some V H /V L sdAbs had marked growth advantages over others, and that the amino acid composition of the CDRs of this set of sdAbs was dramatically restricted (bias toward Asp and His and away from aromatic and hydrophobic residues). Thus, CDR sequence

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

International Nuclear Information System (INIS)

Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen; Powell, Harold R.; Leslie, Andrew G. W.

2011-01-01

A new graphical user interface to the MOSFLM program has been developed to simplify the processing of macromolecular diffraction data. The interface, iMOSFLM, allows data processing via a series of clearly defined tasks and provides visual feedback on the progress of each stage. iMOSFLM is a graphical user interface to the diffraction data-integration program MOSFLM. It is designed to simplify data processing by dividing the process into a series of steps, which are normally carried out sequentially. Each step has its own display pane, allowing control over parameters that influence that step and providing graphical feedback to the user. Suitable values for integration parameters are set automatically, but additional menus provide a detailed level of control for experienced users. The image display and the interfaces to the different tasks (indexing, strategy calculation, cell refinement, integration and history) are described. The most important parameters for each step and the best way of assessing success or failure are discussed

Displaying DIII-D plasma data using DEC's X window system

International Nuclear Information System (INIS)

Greene, K.L.

1991-11-01

The D3-D tokamak program, funded by the Department of Energy, carries out plasma physics and fusion energy research experiments. The machine began operation in February 1986; at that time, approximately 7 Mbytes of data was collected for shot. Since that time, the shot size has steadily increased to over 50 Mbytes with the average shot size between 35 and 45 Mbytes. Shots are fired every 12 to 15 minutes and last approximately 5 to 10 seconds. Between 30 and 40 shots are fired each day when plasma experiments are scheduled. In 1987 MFITD and MFITPLAY were written/modified. These two programs provide graphical output that allows the users to see, before the next shot, the plasma shape and the locations of the plasma and magnetic flux lines within the tokamak. MFITD performs the computations which calculate the shape and location of the plasma; it also graphically displays a small subset of timeslice data. MFITPLAY graphically displays the full set of timeslice data. Through interactive commands, MFITPLAY also allows the user to control the various aspects of how the data is displayed. In 1990, both programs were converted from User Interface Services (UIS) routines, which are part of the MicroVMS workstation graphics software, to DEC's X Window System using the DECWindows window manager. These modifications were required because of a move by Digital Equipment Corporation (DEC) to support X windows and phase out UIS. Due to the nature and purpose of each program, MFITD needed only simple graphics conversion while MFITPLAY was completely rewritten. The DECWindows version of MFITPLAY offers a number of improvements, such as a more intuitive user interface

Real-time flight test data distribution and display

Science.gov (United States)

Nesel, Michael C.; Hammons, Kevin R.

1988-01-01

Enhancements to the real-time processing and display systems of the NASA Western Aeronautical Test Range are described. Display processing has been moved out of the telemetry and radar acquisition processing systems super-minicomputers into user/client interactive graphic workstations. Real-time data is provided to the workstations by way of Ethernet. Future enhancement plans include use of fiber optic cable to replace the Ethernet.

Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries.

Science.gov (United States)

El Zoeiby, Ahmed; Sanschagrin, François; Darveau, André; Brisson, Jean-Robert; Levesque, Roger C

2003-03-01

The machinery of peptidoglycan biosynthesis is an ideal site at which to look for novel antimicrobial targets. Phage display was used to develop novel peptide inhibitors for MurC, an essential enzyme involved in the early steps of biosynthesis of peptidoglycan monomer. We cloned and overexpressed the murA, -B and -C genes from Pseudomonas aeruginosa in the pET expression vector, adding a His-tag to their C termini. The three proteins were overproduced in Escherichia coli and purified to homogeneity in milligram quantities. MurA and -B were combinatorially used to synthesize the MurC substrate UDP-N-acetylmuramate, the identity of which was confirmed by mass spectrometry and nuclear magnetic resonance analysis. Two phage-display libraries were screened against MurC in order to identify peptide ligands to the enzyme. Three rounds of biopanning were carried out, successively increasing elution specificity from round 1 to 3. The third round was accomplished with both non-specific elution and competitive elution with each of the three MurC substrates, UDP-N-acetylmuramic acid (UNAM), ATP and L-alanine. The DNA of 10 phage, selected randomly from each group, was extracted and sequenced, and consensus peptide sequences were elucidated. Peptides were synthesized and tested for inhibition of the MurC-catalysed reaction, and two peptides were shown to be inhibitors of MurC activity with IC(50)s of 1.5 and 0.9 mM, respectively. The powerful selection technique of phage display allowed us to identify two peptide inhibitors of the essential bacterial enzyme MurC. The peptide sequences represent the basis for the synthesis of inhibitory peptidomimetic molecules.

Separate but Equal? A Comparison of Content on Library Web Pages and Their Text Versions

Science.gov (United States)

Hazard, Brenda L.

2008-01-01

This study examines the Web sites of the Association of Research Libraries member libraries to determine the presence of a separate text version of the default graphical homepage. The content of the text version and the homepage is compared. Of 121 Web sites examined, twenty libraries currently offer a text version. Ten sites maintain wholly…

Computing and Displaying Isosurfaces in R

Directory of Open Access Journals (Sweden)

Dai Feng

2008-09-01

Full Text Available This paper presents R utilities for computing and displaying isosurfaces, or three-dimensional contour surfaces, from a three-dimensional array of function values. A version of the marching cubes algorithm that takes into account face and internal ambiguities is used to compute the isosurfaces. Vectorization is used to ensure adequate performance using only R code. Examples are presented showing contours of theoretical densities, density estimates, and medical imaging data. Rendering can use the rgl package or standard or grid graphics, and a set of tools for representing and rendering surfaces using standard or grid graphics is presented.

CORDSPW - Windows computer program package for graphical interpretation of CORD-2 data

International Nuclear Information System (INIS)

Slavic, S.; Kromar, M.

2007-01-01

The CORD-2 package, developed at Jozef Stefan Institute, enables determination of the core power distribution and reactivity. Core distributions data generated during the calculation process are stored in CORlib files. CORDSP code, which is a part of the CORD-2 package, displays and compares data contained in CORlib files. Since it runs in the DOS environment, there are several limitations in the presentation of desired data. A CORDSPW package runs in the Windows environment and offers better graphical interpretation of the CORlib data. Core distributions can be displayed, compared, rewritten in the new files and sent to the printer. The user can select the appropriate display of the presented data such as core symmetry, colour and fonts. Core radial and axial distributions can be presented and compared. There are several options to store and print data. The user can choose between standard ASCII and graphical JPG format. (author)

Three-dimensional display techniques: description and critique of methods

International Nuclear Information System (INIS)

Budinger, T.F.

1982-01-01

The recent advances in non invasive medical imaging of 3 dimensional spatial distribution of radionuclides, X-ray attenuation coefficients, and nuclear magnetic resonance parameters necessitate development of a general method for displaying these data. The objective of this paper is to give a systematic description and comparison of known methods for displaying three dimensional data. The discussion of display methods is divided into two major categories: 1) computer-graphics methods which use a two dimensional display screen; and 2) optical methods (such as holography, stereopsis and vari-focal systems)

Interactive graphics for the Macintosh: software review of FlexiGraphs.

Science.gov (United States)

Antonak, R F

1990-01-01

While this product is clearly unique, its usefulness to individuals outside small business environments is somewhat limited. FlexiGraphs is, however, a reasonable first attempt to design a microcomputer software package that controls data through interactive editing within a graph. Although the graphics capabilities of mainframe programs such as MINITAB (Ryan, Joiner, & Ryan, 1981) and the graphic manipulations available through exploratory data analysis (e.g., Velleman & Hoaglin, 1981) will not be surpassed anytime soon by this program, a researcher may want to add this program to a software library containing other Macintosh statistics, drawing, and graphics programs if only to obtain the easy-to-obtain curve fitting and line smoothing options. I welcome the opportunity to review the enhanced "scientific" version of FlexiGraphs that the author of the program indicates is currently under development. An MS-DOS version of the program should be available within the year.

Exhibits in libraries a practical guide

CERN Document Server

Brown, Mary E

2005-01-01

"Ccomprehensive...detailed"--Booklist; "thoroughly reseached...highly recommended"--Journal of Access Services. Library exhibits are more than entertainment for patrons. They can inspire and educate, stimulate an interest that can be explored in a book, or attract visitors who otherwise wouldn't stop by. Displays are also an opportunity for a library to put its creative foot forward or help patrons navigate the facility itself. This comprehensive "how-to" includes everything a librarian or staff member needs to know to put on an exhibit, from hatching ideas to evaluating the end result. Illustrations and photographs show practical methods of planning, labeling and displaying.

Screening and Identification of Peptides Specifically Targeted to Gastric Cancer Cells from a Phage Display Peptide Library

Science.gov (United States)

Sahin, Deniz; Taflan, Sevket Onur; Yartas, Gizem; Ashktorab, Hassan; Smoot, Duane T

2018-04-25

Background: Gastric cancer is the second most common cancer among the malign cancer types. Inefficiency of traditional techniques both in diagnosis and therapy of the disease makes the development of alternative and novel techniques indispensable. As an alternative to traditional methods, tumor specific targeting small peptides can be used to increase the efficiency of the treatment and reduce the side effects related to traditional techniques. The aim of this study is screening and identification of individual peptides specifically targeted to human gastric cancer cells using a phage-displayed peptide library and designing specific peptide sequences by using experimentally-eluted peptide sequences. Methods: Here, MKN-45 human gastric cancer cells and HFE-145 human normal gastric epithelial cells were used as the target and control cells, respectively. 5 rounds of biopannning with a phage display 12-peptide library were applied following subtraction biopanning with HFE-145 control cells. The selected phage clones were established by enzyme-linked immunosorbent assay and immunofluorescence detection. We first obtain random phage clones after five biopanning rounds, determine the binding levels of each individual clone. Then, we analyze the frequencies of each amino acid in best binding clones to determine positively overexpressed amino acids for designing novel peptide sequences. Results: DE532 (VETSQYFRGTLS) phage clone was screened positive, showing specific binding on MKN-45 gastric cancer cells. DE-Obs (HNDLFPSWYHNY) peptide, which was designed by using amino acid frequencies of experimentally selected peptides in the 5th round of biopanning, showed specific binding in MKN-45 cells. Conclusion: Selection and characterization of individual clones may give us specifically binding peptides, but more importantly, data extracted from eluted phage clones may be used to design theoretical peptides with better binding properties than even experimentally selected ones

Advancing satellite operations with intelligent graphical monitoring systems

Science.gov (United States)

Hughes, Peter M.; Shirah, Gregory W.; Luczak, Edward C.

1993-01-01

For nearly twenty-five years, spacecraft missions have been operated in essentially the same manner: human operators monitor displays filled with alphanumeric text watching for limit violations or other indicators that signal a problem. The task is performed predominately by humans. Only in recent years have graphical user interfaces and expert systems been accepted within the control center environment to help reduce operator workloads. Unfortunately, the development of these systems is often time consuming and costly. At the NASA Goddard Space Flight Center (GSFC), a new domain specific expert system development tool called the Generic Spacecraft Analyst Assistant (GenSAA) has been developed. Through the use of a highly graphical user interface and point-and-click operation, GenSAA facilitates the rapid, 'programming-free' construction of intelligent graphical monitoring systems to serve as real-time, fault-isolation assistants for spacecraft analysts. Although specifically developed to support real-time satellite monitoring, GenSAA can support the development of intelligent graphical monitoring systems in a variety of space and commercial applications.

Characterizing chemical systems with on-line computers and graphics

International Nuclear Information System (INIS)

Frazer, J.W.; Rigdon, L.P.; Brand, H.R.; Pomernacki, C.L.

1979-01-01

Incorporating computers and graphics on-line to chemical experiments and processes opens up new opportunities for the study and control of complex systems. Systems having many variables can be characterized even when the variable interactions are nonlinear, and the system cannot a priori be represented by numerical methods and models. That is, large sets of accurate data can be rapidly acquired, then modeling and graphic techniques can be used to obtain partial interpretation plus design of further experimentation. The experimenter can thus comparatively quickly iterate between experimentation and modeling to obtain a final solution. We have designed and characterized a versatile computer-controlled apparatus for chemical research, which incorporates on-line instrumentation and graphics. It can be used to determine the mechanism of enzyme-induced reactions or to optimize analytical methods. The apparatus can also be operated as a pilot plant to design control strategies. On-line graphics were used to display conventional plots used by biochemists and three-dimensional response-surface plots

The application of visual communication design in display design

Institute of Scientific and Technical Information of China (English)

仪晓华

2015-01-01

Visual communication design is a kind of visual language and the art of communication behavior, it condenses complex and chaos and obscure information can in the shortest possible time to be understanding of the functional information, at the same time, make the design work itself sound art, philosophy and culture, cause the audience’s perception experience and emotional resonance, and eventually approved. Display of visual communication don’t like people use language to convey, but in all kinds of display environment by graphics, text, color elements such as passing information to people, visual communication design as a medium between designer and audience, communicate through planar graphic elements, format design, the combination of the text elements, color elements make exhibition has rhythm beauty so as to build a display space, the space information accurate, vivid and clear function division, comfortable, and the outline of rich imagination space to the person and strong visual impression.

Computer generated multi-color graphics in whole body gamma spectral analysis

International Nuclear Information System (INIS)

Phillips, W.G.; Curtis, S.P.; Environmental Protection Agency, Las Vegas, NV)

1984-01-01

A medium resolution color graphics terminal (512 x 512 pixels) was appended to a computerized gamma spectrometer for the display of whole body counting data. The color display enhances the ability of a spectroscopist to identify at a glance multicolored spectral regions of interest immediate qualitative interpretation. Spectral data from subjects containing low concentrations of gamma emitters obtained by both NaI(T1) and phoswich detectors are viewed by the method. In addition, software generates a multispectral display by which the gross, background, and net spectra are displayed in color simultaneously on a single screen

THERMLIB: a material property data library for thermal analysis of radioactive material transport casks

International Nuclear Information System (INIS)

Ikushima, Takeshi

1998-03-01

The paper describes an heat conduction data library and graphical program for analysis of radioactive material transport casks. More than 1000 of material data are compiled in the data library which was produced by Lawrence Livermore Laboratory. Thermal data such as, density, thermal conductivity, specific heat, phase-change or solid-state, transition temperature and latent heat have been tabulated. Using this data library, a data library processing program THERMLIB for thermal analysis has been developed. Main features of THERMLIB are as follows: (1) data have been tabulated against temperature, (2) more than 1000 material data are available, (3) it is capable of graphical representations for thermal data and (4) not only main frame computer but also work stations (OS UNIX) and personal computer (OS Windows) are available for use of THERMLIB. In the paper, brief illustration of data library is presented in the first section. The second section presents descriptions of structural data. The third section provides an user's guide for computer program and input data for THERMLIB. (author)

THERMLIB: a material property data library for thermal analysis of radioactive material transport casks

Energy Technology Data Exchange (ETDEWEB)

Ikushima, Takeshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1998-03-01

The paper describes an heat conduction data library and graphical program for analysis of radioactive material transport casks. More than 1000 of material data are compiled in the data library which was produced by Lawrence Livermore Laboratory. Thermal data such as, density, thermal conductivity, specific heat, phase-change or solid-state, transition temperature and latent heat have been tabulated. Using this data library, a data library processing program THERMLIB for thermal analysis has been developed. Main features of THERMLIB are as follows: (1) data have been tabulated against temperature, (2) more than 1000 material data are available, (3) it is capable of graphical representations for thermal data and (4) not only main frame computer but also work stations (OS UNIX) and personal computer (OS Windows) are available for use of THERMLIB. In the paper, brief illustration of data library is presented in the first section. The second section presents descriptions of structural data. The third section provides an user`s guide for computer program and input data for THERMLIB. (author)

Three-dimensional modeler for animated images display system

International Nuclear Information System (INIS)

Boubekeur, Rania

1987-01-01

The mv3d software allows the modeling and display of three dimensional objects in interpretative mode with animation possibility in real time. This system is intended for a graphical extension of a FORTH interpreter (implemented by CEA/IRDI/D.LETI/DEIN) in order to control a specific hardware (3.D card designed and implemented by DEIN) allowing the generation of three dimensional objects. The object description is carried out with a specific graphical language integrated in the FORTH interpreter. Objects are modeled using elementary solids called basic forms (cube, cone, cylinder...) assembled with classical geometric transformations (rotation, translation and scaling). These basic forms are approximated by plane polygonal facets further divided in triangles. Coordinates of the summits of triangles constitute the geometrical data. These are sent to the 3.D. card for processing and display. Performed processing are: geometrical transformations on display, hidden surface elimination, shading and clipping. The mv3d software is not an entire modeler but a simple, modular and extensible tool, to which other specific functions may be easily added such as: robots motion, collisions... (author) [fr

News from the Library: PressDisplay on mobile devices!

CERN Multimedia

CERN Library

2013-01-01

You are probably already using PressDisplay to read newspapers online, but for those of you who are not yet aware of this service, PressDisplay is an online portal where you can browse and read online articles from more than 1,900 newspapers from 95 countries, as soon as they are published.   Whether you are an experienced user or a beginner, we have good news concerning PressDisplay: our license now permits you to download complete newspaper issues to your mobile devices and read them offline wherever you like. To do that, you have to use the mobile app PressReader. Instructions on how to install the PressReader app are available here: For Ipad For Android smartphone For Android tablet For Windows 8 devices For BlackBerry Playbook For Android eReader Your feedback is welcome! Please contact us by e-mail.

PRINCIPLES OF INDICATION FOR EN-ROUTE FLIGHT PATHS OF THE AIRCRAFT ON THE SCREEN OF ON-BOARD DISPLAY DEVICES

Directory of Open Access Journals (Sweden)

V. V. Markelov

2016-01-01

Full Text Available Subject of Research.We consider the principles and algorithms for construction of en-route flight paths of an aircraft (airplane in a horizontal plane for their subsequent display on the navigation situation indicators in the cockpit. Navigation situation indicatorsaredisplay devices designed on the basis of flat liquid crystal panel. Methods. Flight trajectory display by on-board multifunction indicators is performed by successive drawing of graphic primitives available in the library and defined in accordance with an array of data to display the route. An array of data is generated by on-board software complex based on the information provided in the flight task and the corresponding «Jeppesen» database or analogous one. Formation of the array is carried out by bringing the set of trajectory paths to the format of three typical trajectories described. In addition, each of the types of trajectories has a standard description of the algorithm for calculating the parameters that make up an array of data to display.Main Results.The algorithms of forming and calculating the amounts of data of routing paths required for their construction and display on the multifunction indicators applied in avionics.Practical Relevance.These novel routing algorithms for constructing trajectory paths unify algorithms of generating information for display on the navigation situation indicators and optimize a set of calculated data for flight control at the trajectory in the horizontal plane.

Basics of Antibody Phage Display Technology.

Science.gov (United States)

Ledsgaard, Line; Kilstrup, Mogens; Karatt-Vellatt, Aneesh; McCafferty, John; Laustsen, Andreas H

2018-06-09

Antibody discovery has become increasingly important in almost all areas of modern medicine. Different antibody discovery approaches exist, but one that has gained increasing interest in the field of toxinology and antivenom research is phage display technology. In this review, the lifecycle of the M13 phage and the basics of phage display technology are presented together with important factors influencing the success rates of phage display experiments. Moreover, the pros and cons of different antigen display methods and the use of naïve versus immunized phage display antibody libraries is discussed, and selected examples from the field of antivenom research are highlighted. This review thus provides in-depth knowledge on the principles and use of phage display technology with a special focus on discovery of antibodies that target animal toxins.

Software Graphical User Interface For Analysis Of Images

Science.gov (United States)

Leonard, Desiree M.; Nolf, Scott R.; Avis, Elizabeth L.; Stacy, Kathryn

1992-01-01

CAMTOOL software provides graphical interface between Sun Microsystems workstation and Eikonix Model 1412 digitizing camera system. Camera scans and digitizes images, halftones, reflectives, transmissives, rigid or flexible flat material, or three-dimensional objects. Users digitize images and select from three destinations: work-station display screen, magnetic-tape drive, or hard disk. Written in C.

IDEA: Interactive Display for Evolutionary Analyses

Directory of Open Access Journals (Sweden)

Carlton Jane M

2008-12-01

Full Text Available Abstract Background The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints and other molecular evolution variables of interest an increasingly important approach to addressing broad evolutionary questions. Two of the programs most widely used for this purpose are codeml and baseml, parts of the PAML (Phylogenetic Analysis by Maximum Likelihood suite. A significant drawback of these programs is their lack of a graphical user interface, which can limit their user base and considerably reduce their efficiency. Results We have developed IDEA (Interactive Display for Evolutionary Analyses, an intuitive graphical input and output interface which interacts with PHYLIP for phylogeny reconstruction and with codeml and baseml for molecular evolution analyses. IDEA's graphical input and visualization interfaces eliminate the need to edit and parse text input and output files, reducing the likelihood of errors and improving processing time. Further, its interactive output display gives the user immediate access to results. Finally, IDEA can process data in parallel on a local machine or computing grid, allowing genome-wide analyses to be completed quickly. Conclusion IDEA provides a graphical user interface that allows the user to follow a codeml or baseml analysis from parameter input through to the exploration of results. Novel options streamline the analysis process, and post-analysis visualization of phylogenies, evolutionary rates and selective constraint along protein sequences simplifies the interpretation of results. The integration of these functions into a single tool eliminates the need for lengthy data handling and parsing, significantly expediting access to global patterns in the data.

Guide to making time-lapse graphics using the facilities of the National Magnetic Fusion Energy Computing Center

International Nuclear Information System (INIS)

Munro, J.K. Jr.

1980-05-01

The advent of large, fast computers has opened the way to modeling more complex physical processes and to handling very large quantities of experimental data. The amount of information that can be processed in a short period of time is so great that use of graphical displays assumes greater importance as a means of displaying this information. Information from dynamical processes can be displayed conveniently by use of animated graphics. This guide presents the basic techniques for generating black and white animated graphics, with consideration of aesthetic, mechanical, and computational problems. The guide is intended for use by someone who wants to make movies on the National Magnetic Fusion Energy Computing Center (NMFECC) CDC-7600. Problems encountered by a geographically remote user are given particular attention. Detailed information is given that will allow a remote user to do some file checking and diagnosis before giving graphics files to the system for processing into film in order to spot problems without having to wait for film to be delivered. Source listings of some useful software are given in appendices along with descriptions of how to use it. 3 figures, 5 tables

Librarian driven analysis with graphic user interface for nuclides quantification by gamma spectra

Energy Technology Data Exchange (ETDEWEB)

Kondrashov, V.S. E-mail: vlkondra@cdrewu.edu; Rothenberg, S.J.; Petersone, I

2001-09-11

For a set of a priori given radionuclides extracted from a general nuclide data library, the authors use median estimates of the gamma-peak areas and estimates to produce a list of possible radionuclides matching gamma-ray line(s). An a priori determined list of nuclides is obtained by searching for a match with the energy information of the database. This procedure is performed in an interactive graphic mode by markers that superimpose, on the spectral data, the energy information and yields provided by a general gamma-ray data library. This library of experimental data includes approximately 17,000 gamma-energy lines related to 756 known gamma emitter radionuclides listed by ICRP.

Identification of a novel aFGF-binding peptide with anti-tumor effect on breast cancer from phage display library

Energy Technology Data Exchange (ETDEWEB)

Dai, Xiaoyong; Cai, Cuizan [College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong (China); Xiao, Fei [Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong (China); Xiong, Yaoling [College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong (China); Huang, Yadong; Zhang, Qihao [Department of Biopharmaceutical Research and Development Centre, Institute of Biomedicine, Jinan University, Guangzhou 510632, Guangdong (China); Xiang, Qi [College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong (China); Lou, Guofeng [Department of Biopharmaceutical Research and Development Centre, Institute of Biomedicine, Jinan University, Guangzhou 510632, Guangdong (China); Lian, Mengyang [College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong (China); Su, Zhijian, E-mail: tjnuszj@jnu.edu.cn [Department of Biopharmaceutical Research and Development Centre, Institute of Biomedicine, Jinan University, Guangzhou 510632, Guangdong (China); Zheng, Qing, E-mail: tzhengq@jnu.edu.cn [College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong (China)

2014-03-21

Highlights: • A specific aFGF-binding peptide AP8 was identified from a phage display library. • AP8 could inhibit aFGF-stimulated cell proliferation in a dose-dependent manner. • AP8 arrested the cell cycle at the G0/G1 phase by suppressing Cyclin D1. • AP8 could block the activation of Erk1/2 and Akt kinase. • AP8 counteracted proliferation and cell cycle via influencing PA2G4 and PCNA. - Abstract: It has been reported that acidic fibroblast growth factor (aFGF) is expressed in breast cancer and via interactions with fibroblast growth factor receptors (FGFRs) to promote the stage and grade of the disease. Thus, aFGF/FGFRs have been considered essential targets in breast cancer therapy. We identified a specific aFGF-binding peptide (AGNWTPI, named AP8) from a phage display heptapeptide library with aFGF after four rounds of biopanning. The peptide AP8 contained two (TP) amino acids identical and showed high homology to the peptides of the 182–188 (GTPNPTL) site of high-affinity aFGF receptor FGFR1. Functional analyses indicated that AP8 specifically competed with the corresponding phage clone A8 for binding to aFGF. In addition, AP8 could inhibit aFGF-stimulated cell proliferation, arrested the cell cycle at the G0/G1 phase by increasing PA2G4 and suppressing Cyclin D1 and PCNA, and blocked the aFGF-induced activation of Erk1/2 and Akt kinase in both breast cancer cells and vascular endothelial cells. Therefore, these results indicate that peptide AP8, acting as an aFGF antagonist, is a promising therapeutic agent for the treatment of breast cancer.

Graphical debugging of combinational geometry

International Nuclear Information System (INIS)

Burns, T.J.; Smith, M.S.

1992-01-01

A graphical debugger for combinatorial geometry being developed at Oak Ridge National Laboratory is described. The prototype debugger consists of two parts: a FORTRAN-based ''view'' generator and a Microsoft Windows application for displaying the geometry. Options and features of both modules are discussed. Examples illustrating the various options available are presented. The potential for utilizing the images produced using the debugger as a visualization tool for the output of the radiation transport codes is discussed as is the future direction of the development

Data analysis using a data base driven graphics animation system

International Nuclear Information System (INIS)

Schwieder, D.H.; Stewart, H.D.; Curtis, J.N.

1985-01-01

A graphics animation system has been developed at the Idaho National Engineering Laboratory (INEL) to assist engineers in the analysis of large amounts of time series data. Most prior attempts at computer animation of data involve the development of large and expensive problem-specific systems. This paper discusses a generalized interactive computer animation system designed to be used in a wide variety of data analysis applications. By using relational data base storage of graphics and control information, considerable flexibility in design and development of animated displays is achieved

The practical use of computer graphics techniques for site characterization

International Nuclear Information System (INIS)

Tencer, B.; Newell, J.C.

1982-01-01

In this paper the authors describe the approach utilized by Roy F. Weston, Inc. (WESTON) to analyze and characterize data relative to a specific site and the computerized graphical techniques developed to display site characterization data. These techniques reduce massive amounts of tabular data to a limited number of graphics easily understood by both the public and policy level decision makers. First, they describe the general design of the system; then the application of this system to a low level rad site followed by a description of an application to an uncontrolled hazardous waste site

Biopanning and characterization of peptides with Fe3O4 nanoparticles-binding capability via phage display random peptide library technique.

Science.gov (United States)

You, Fei; Yin, Guangfu; Pu, Ximing; Li, Yucan; Hu, Yang; Huang, Zhongbin; Liao, Xiaoming; Yao, Yadong; Chen, Xianchun

2016-05-01

Functionalization of inorganic nanoparticles (NPs) play an important role in biomedical applications. A proper functionalization of NPs can improve biocompatibility, avoid a loss of bioactivity, and further endow NPs with unique performances. Modification with vairous specific binding biomolecules from random biological libraries has been explored. In this work, two 7-mer peptides with sequences of HYIDFRW and TVNFKLY were selected from a phage display random peptide library by using ferromagnetic NPs as targets, and were verified to display strong binding affinity to Fe3O4 NPs. Fourier transform infrared spectrometry, fluorescence microscopy, thermal analysis and X-ray photoelectron spectroscopy confirmed the presence of peptides on the surface of Fe3O4 NPs. Sequence analyses revealed that the probable binding mechanism between the peptide and Fe3O4 NPs might be driven by Pearson hard acid-hard base specific interaction and hydrogen bonds, accompanied with hydrophilic interactions and non-specific electrostatic attractions. The cell viability assay indicated a good cytocompatibility of peptide-bound Fe3O4 NPs. Furthermore, TVNFKLY peptide and an ovarian tumor cell A2780 specific binding peptide (QQTNWSL) were conjugated to afford a liner 14-mer peptide (QQTNWSLTVNFKLY). The binding and targeting studies showed that 14-mer peptide was able to retain both the strong binding ability to Fe3O4 NPs and the specific binding ability to A2780 cells. The results suggested that the Fe3O4-binding peptides would be of great potential in the functionalization of Fe3O4 NPs for the tumor-targeted drug delivery and magnetic hyperthermia. Copyright © 2016 Elsevier B.V. All rights reserved.

Commercial Off-The-Shelf (COTS) Graphics Processing Board (GPB) Radiation Test Evaluation Report

Science.gov (United States)

Salazar, George A.; Steele, Glen F.

2013-01-01

Large round trip communications latency for deep space missions will require more onboard computational capabilities to enable the space vehicle to undertake many tasks that have traditionally been ground-based, mission control responsibilities. As a result, visual display graphics will be required to provide simpler vehicle situational awareness through graphical representations, as well as provide capabilities never before done in a space mission, such as augmented reality for in-flight maintenance or Telepresence activities. These capabilities will require graphics processors and associated support electronic components for high computational graphics processing. In an effort to understand the performance of commercial graphics card electronics operating in the expected radiation environment, a preliminary test was performed on five commercial offthe- shelf (COTS) graphics cards. This paper discusses the preliminary evaluation test results of five COTS graphics processing cards tested to the International Space Station (ISS) low earth orbit radiation environment. Three of the five graphics cards were tested to a total dose of 6000 rads (Si). The test articles, test configuration, preliminary results, and recommendations are discussed.

Development of a Relap based Nuclear Plant Analyser with 3-D graphics using OpenGL and Object Relap

International Nuclear Information System (INIS)

Lee, Young Jin

2010-01-01

A 3-D Graphic Nuclear Plant Analyzer (NPA) program was developed using GLScene and the TRelap. GLScene is an OpenGL based 3D graphics library for the Delphi object-oriented program language, and it implements the OpenGL functions in forms suitable for programming with Delphi. TRelap is an object wrapper developed by the author to easily implement the Relap5 thermal hydraulic code under object oriented programming environment. The 3-D Graphic NPA was developed to demonstrate the superiority of the object oriented programming approach in developing complex programs

EBR-II Cover Gas Cleanup System (CGCS) upgrade graphical interface design

International Nuclear Information System (INIS)

Staffon, J.D.; Peters, G.G.

1992-01-01

Technology advances in the past few years have prompted an effort at Argonne National Laboratory to replace existing equipment with high performance digital computers and color graphic displays. Improved operation of process systems can be achieved by utilizing state-of-the-art computer technology in the areas of process control and process monitoring. The Cover Gas Cleanup System (CGCS) at EBR-II is the first system to be upgraded with high performance digital equipment. The upgrade consisted of a main control computer, a distributed control computer, a front end input/output computer, a main graphics interface terminal, and a remote graphics interface terminal. This paper describes the main control computer and the operator interface control software

Developing an integrated digitizing and display surface

Science.gov (United States)

Hipple, James D.; Wedding, Daniel K.; Wedding, Donald K., Sr.

1995-04-01

The development of an integrated digitizing and display surface, which utilizes touch entry and flat panel display (FPD) technology, is a significant hardware advance in the field of geographic information systems (GIS). Inherent qualities of the FPD, notably the ac gas plasma display, makes such a marriage inevitable. Large diagonal sizes, high resolution color, screen flatness, and monitor thickness are desirable features of an integrated digitizing and display surface. Recently, the GIS literature has addressed a need for such an innovation. The development of graphics displays based on sophisticated technologies include `photorealistic' (or high definition) imaging at resolutions of 2048 X 2048 or greater, palates of 16.7 million colors, formats greater than 30 inches diagonal, and integrated touch entry. In this paper, there is an evaluation of FPDs and data input technologies in the development of such a product.

Generating Animated Displays of Spacecraft Orbits

Science.gov (United States)

Candey, Robert M.; Chimiak, Reine A.; Harris, Bernard T.

2005-01-01

Tool for Interactive Plotting, Sonification, and 3D Orbit Display (TIPSOD) is a computer program for generating interactive, animated, four-dimensional (space and time) displays of spacecraft orbits. TIPSOD utilizes the programming interface of the Satellite Situation Center Web (SSCWeb) services to communicate with the SSC logic and database by use of the open protocols of the Internet. TIPSOD is implemented in Java 3D and effects an extension of the preexisting SSCWeb two-dimensional static graphical displays of orbits. Orbits can be displayed in any or all of the following seven reference systems: true-of-date (an inertial system), J2000 (another inertial system), geographic, geomagnetic, geocentric solar ecliptic, geocentric solar magnetospheric, and solar magnetic. In addition to orbits, TIPSOD computes and displays Sibeck's magnetopause and Fairfield's bow-shock surfaces. TIPSOD can be used by the scientific community as a means of projection or interpretation. It also has potential as an educational tool.

Production of a phage-displayed single chain variable fragment ...

African Journals Online (AJOL)

Purpose: To develop specific single chain variable fragments (scFv) against infectious bursal disease virus (IBDV) via phage display technology. Methods: Purified viruses were initially applied for iterative panning rounds of scFv phage display libraries. The binding ability of the selected scFv antibody fragments against the ...

Ajax, XSLT and SVG: Displaying ATLAS conditions data with new web technologies

Energy Technology Data Exchange (ETDEWEB)

Roe, S A, E-mail: shaun.roe@cern.c [CERN, CH-1211 Geneve 23 (Switzerland)

2010-04-01

The combination of three relatively recent technologies is described which allows an easy path from database retrieval to interactive web display. SQL queries on an Oracle database can be performed in a manner which directly return an XML description of the result, and Ajax techniques (Asynchronous JavaScript And XML) are used to dynamically inject the data into a web display accompanied by an XSLT transform template which determines how the data will be formatted. By tuning the transform to generate SVG (Scalable Vector Graphics) a direct graphical representation can be produced in the web page while retaining the database data as the XML source, allowing dynamic links to be generated in the web representation, but programmatic use of the data when used from a user application. With the release of the SVG 1.2 Tiny draft specification, the display can also be tailored for display on mobile devices. The technologies are described and a sample application demonstrated, showing conditions data from the ATLAS Semiconductor Tracker.

Ajax, XSLT and SVG: Displaying ATLAS conditions data with new web technologies

International Nuclear Information System (INIS)

Roe, S A

2010-01-01

The combination of three relatively recent technologies is described which allows an easy path from database retrieval to interactive web display. SQL queries on an Oracle database can be performed in a manner which directly return an XML description of the result, and Ajax techniques (Asynchronous JavaScript And XML) are used to dynamically inject the data into a web display accompanied by an XSLT transform template which determines how the data will be formatted. By tuning the transform to generate SVG (Scalable Vector Graphics) a direct graphical representation can be produced in the web page while retaining the database data as the XML source, allowing dynamic links to be generated in the web representation, but programmatic use of the data when used from a user application. With the release of the SVG 1.2 Tiny draft specification, the display can also be tailored for display on mobile devices. The technologies are described and a sample application demonstrated, showing conditions data from the ATLAS Semiconductor Tracker.

Ajax, XSLT and SVG: Displaying ATLAS conditions data with new web technologies

CERN Document Server

Roe, S A

2010-01-01

The combination of three relatively recent technologies is described which allows an easy path from database retrieval to interactive web display. SQL queries on an Oracle database can be performed in a manner which directly return an XML description of the result, and Ajax techniques (Asynchronous JavaScript And XML) are used to dynamically inject the data into a web display accompanied by an XSLT transform template which determines how the data will be formatted. By tuning the transform to generate SVG (Scalable Vector Graphics) a direct graphical representation can be produced in the web page while retaining the database data as the XML source, allowing dynamic links to be generated in the web representation, but programmatic use of the data when used from a user application. With the release of the SVG 1.2 Tiny draft specification, the display can also be tailored for display on mobile devices. The technologies are described and a sample application demonstrated, showing conditions data from the ATLAS Sem...

Screening of synthetic phage display scFv libraries yields competitive ligands of human leptin receptor.

Science.gov (United States)

Molek, Peter; Vodnik, Miha; Strukelj, Borut; Bratkovič, Tomaž

2014-09-26

Initially considered the main endogenous anorexigenic factor, fat-derived leptin turned out to be a markedly pleiotropic hormone, influencing diverse physiological processes. Moreover, hyperleptinemia in obese individuals has been linked to the onset or progression of serious disorders, such as cancer, autoimmune diseases, and atherosclerosis, and antagonizing peripheral leptin's signalization has been shown to improve these conditions. To develop an antibody-based leptin antagonist we have devised a tailored panning procedure and screened two phage display libraries of single chain variable antibody fragments (scFvs) against recombinant leptin receptor. One of the scFvs was expressed in Escherichia coli and its interaction with leptin receptor was characterized in more detail. It was found to recognize a discontinuous epitope and to compete with leptin for receptor binding with IC50 and Kd values in the nanomolar range. The reported scFv represents a lead for development of leptin antagonists that may ultimately find use in therapy of various hyperleptinemia-related disorders. Copyright © 2014 Elsevier Inc. All rights reserved.

GRAPHIC, time-sharing magnet design computer programs at Argonne

International Nuclear Information System (INIS)

Lari, R.J.

1974-01-01

This paper describes three magnet design computer programs in use at the Zero Gradient Synchrotron of Argonne National Laboratory. These programs are used in the time sharing mode in conjunction with a Tektronix model 4012 graphic display terminal. The first program in called TRIM, the second MAGNET, and the third GFUN. (U.S.)

Graphical Acoustic Liner Design and Analysis Tool

Science.gov (United States)

Howerton, Brian M. (Inventor); Jones, Michael G. (Inventor)

2016-01-01

An interactive liner design and impedance modeling tool comprises software utilized to design acoustic liners for use in constrained spaces, both regularly and irregularly shaped. A graphical user interface allows the acoustic channel geometry to be drawn in a liner volume while the surface impedance calculations are updated and displayed in real-time. A one-dimensional transmission line model may be used as the basis for the impedance calculations.

An Investigation of Interval Management Displays

Science.gov (United States)

Swieringa, Kurt A.; Wilson, Sara R.; Shay, Rick

2015-01-01

NASA's first Air Traffic Management (ATM) Technology Demonstration (ATD-1) was created to transition the most mature ATM technologies from the laboratory to the National Airspace System. One selected technology is Interval Management (IM), which uses onboard aircraft automation to compute speeds that help the flight crew achieve and maintain precise spacing behind a preceding aircraft. Since ATD-1 focuses on a near-term environment, the ATD-1 flight demonstration prototype requires radio voice communication to issue an IM clearance. Retrofit IM displays will enable pilots to both enter information into the IM avionics and monitor IM operation. These displays could consist of an interface to enter data from an IM clearance and also an auxiliary display that presents critical information in the primary field-of-view. A human-in-the-loop experiment was conducted to examine usability and acceptability of retrofit IM displays, which flight crews found acceptable. Results also indicate the need for salient alerting when new speeds are generated and the desire to have a primary field of view display available that can display text and graphic trend indicators.

Distributed rendering for multiview parallax displays

Science.gov (United States)

Annen, T.; Matusik, W.; Pfister, H.; Seidel, H.-P.; Zwicker, M.

2006-02-01

3D display technology holds great promise for the future of television, virtual reality, entertainment, and visualization. Multiview parallax displays deliver stereoscopic views without glasses to arbitrary positions within the viewing zone. These systems must include a high-performance and scalable 3D rendering subsystem in order to generate multiple views at real-time frame rates. This paper describes a distributed rendering system for large-scale multiview parallax displays built with a network of PCs, commodity graphics accelerators, multiple projectors, and multiview screens. The main challenge is to render various perspective views of the scene and assign rendering tasks effectively. In this paper we investigate two different approaches: Optical multiplexing for lenticular screens and software multiplexing for parallax-barrier displays. We describe the construction of large-scale multi-projector 3D display systems using lenticular and parallax-barrier technology. We have developed different distributed rendering algorithms using the Chromium stream-processing framework and evaluate the trade-offs and performance bottlenecks. Our results show that Chromium is well suited for interactive rendering on multiview parallax displays.

Renewing library Web sites CMS at libraries

CERN Document Server

Vida, A

2006-01-01

The use of the Internet has a ten-year history in Hungary. In the beginning, users were surfing on textual Web sites with the browser Lynx (1991), then a range of graphic browsers appeared: Mosaic (1993) , Netscape (1994), and finally Internet Explorer (1995). More and more institutions, including libraries decided to enter the World Wide Web with their own homepage. The past ten years have brought enormous changes and new requirements in the way that institutional homepages are designed. This article offers an overview of the development phases of Web sites, presents the new tools necessary for the state-of-the-art design and gives advice on their up-to-date maintenance.

Investigating pointing tasks across angularly coupled display areas

DEFF Research Database (Denmark)

Hennecke, Fabian; De Luca, Alexander; Nguyen, Ngo Dieu Huong

2013-01-01

Pointing tasks are a crucial part of today’s graphical user interfaces. They are well understood for flat displays and most prominently are modeled through Fitts’ Law. For novel displays (e.g., curved displays with multi-purpose areas), however, it remains unclear whether such models for predicting...... that the target position affects overall pointing speed and offset in both conditions. However, we also found that Fitts’ Law can in fact still be used to predict performance as on flat displays. Our results help designers to optimize user interfaces on angularly coupled displays when pointing tasks are involved....... user performance still hold – in particular when pointing is performed across differently oriented areas. To answer this question, we conducted an experiment on an angularly coupled display – the Curve – with two input conditions: direct touch and indirect mouse pointer. Our findings show...

Decision making in water resource planning: Models and computer graphics

Energy Technology Data Exchange (ETDEWEB)

Fedra, K; Carlsen, A J [ed.

1987-01-01

This paper describes some basic concepts of simulation-based decision support systems for water resources management and the role of symbolic, graphics-based user interfaces. Designed to allow direct and easy access to advanced methods of analysis and decision support for a broad and heterogeneous group of users, these systems combine data base management, system simulation, operations research techniques such as optimization, interactive data analysis, elements of advanced decision technology, and artificial intelligence, with a friendly and conversational, symbolic display oriented user interface. Important features of the interface are the use of several parallel or alternative styles of interaction and display, indlucing colour graphics and natural language. Combining quantitative numerical methods with qualitative and heuristic approaches, and giving the user direct and interactive control over the systems function, human knowledge, experience and judgement are integrated with formal approaches into a tightly coupled man-machine system through an intelligent and easily accessible user interface. 4 drawings, 42 references.

Comparison of the efficiency of antibody selection from semi-synthetic scFv and non-immune Fab phage display libraries against protein targets for rapid development of diagnostic immunoassays.

Science.gov (United States)

Chan, Conrad E Z; Chan, Annie H Y; Lim, Angeline P C; Hanson, Brendon J

2011-10-28

Rapid development of diagnostic immunoassays against novel emerging or genetically modified pathogens in an emergency situation is dependent on the timely isolation of specific antibodies. Non-immune antibody phage display libraries are an efficient in vitro method for selecting monoclonal antibodies and hence ideal in these circumstances. Such libraries can be constructed from a variety of sources e.g. B cell cDNA or synthetically generated, and use a variety of antibody formats, typically scFv or Fab. However, antibody source and format can impact on the quality of antibodies generated and hence the effectiveness of this methodology for the timely production of antibodies. We have carried out a comparative screening of two antibody libraries, a semi-synthetic scFv library and a human-derived Fab library against the protective antigen toxin component of Bacillus anthracis and the epsilon toxin of Clostridium botulinum. We have shown that while the synthetic library produced a diverse collection of specific scFv-phage, these contained a high frequency of unnatural amber stops and glycosylation sites which limited their conversion to IgG, and also a high number which lost specificity when expressed as IgG. In contrast, these limitations were overcome by the use of a natural human library. Antibodies from both libraries could be used to develop sandwich ELISA assays with similar sensitivity. However, the ease and speed with which full-length IgG could be generated from the human-derived Fab library makes screening this type of library the preferable method for rapid antibody generation for diagnostic assay development. Copyright © 2011 Elsevier B.V. All rights reserved.

Advanced Visualization and Interactive Display Rapid Innovation and Discovery Evaluation Research Program task 8: Survey of WEBGL Graphics Engines

Science.gov (United States)

2015-01-01

1 3.0 Methods, Assumptions, and Procedures ...18 4.6.3. LineUp Web... Procedures A search of the internet looking at web sites specializing in graphics, graphics engines, web browser applications, and games was conducted to

Adaptation of Control Center Software to Commerical Real-Time Display Applications

Science.gov (United States)

Collier, Mark D.

1994-01-01

NASA-Marshall Space Flight Center (MSFC) is currently developing an enhanced Huntsville Operation Support Center (HOSC) system designed to support multiple spacecraft missions. The Enhanced HOSC is based upon a distributed computing architecture using graphic workstation hardware and industry standard software including POSIX, X Windows, Motif, TCP/IP, and ANSI C. Southwest Research Institute (SwRI) is currently developing a prototype of the Display Services application for this system. Display Services provides the capability to generate and operate real-time data-driven graphic displays. This prototype is a highly functional application designed to allow system end users to easily generate complex data-driven displays. The prototype is easy to use, flexible, highly functional, and portable. Although this prototype is being developed for NASA-MSFC, the general-purpose real-time display capability can be reused in similar mission and process control environments. This includes any environment depending heavily upon real-time data acquisition and display. Reuse of the prototype will be a straight-forward transition because the prototype is portable, is designed to add new display types easily, has a user interface which is separated from the application code, and is very independent of the specifics of NASA-MSFC's system. Reuse of this prototype in other environments is a excellent alternative to creation of a new custom application, or for environments with a large number of users, to purchasing a COTS package.

Graphics and control for in-reactor operations

International Nuclear Information System (INIS)

Smith, A.L.

1996-01-01

A wide range of manipulator systems has been developed to carry out remotely operated inspection, repair and maintenance tasks at the Magnox reactors in the United Kingdom. A key factor in the improvement of these systems in recent years has been the extensive use of computer graphics as a real-time aid to the manipulator operator. This is exemplified by the reactor pressure vessel inspection work at the Bradwell reactor which is described in detail. The graphics sub-system of the control system for the manipulator plays a unique and wide-ranging role. The 3D modelling and simulation capability of the IGRIP software has contributed to the conceptual design, detailed path planning, rehearsal support, public relations, real-time manipulator display, post inspection documentation and quality assurance. (UK)

The human factors of CRT displays for nuclear power plant control

International Nuclear Information System (INIS)

Danchak, M.M.

1984-01-01

This chapter attempts to show how the Cathode Ray Tube (CRT) can be used to effectively present information to the operator rather than just data. The capabilities of the human as a sensing and information processing subsystem are discussed with CRT displays in mind. The display system is described in terms of its hardware and functioning. The interface between the two is examined by providing substantive guidelines for the effective design of CRT displays for nuclear power plant control. Alphanumeric displays, graphic displays, and representational displays are treated. The design of CRT displays for nuclear power plant control requires an extensive knowledge of cognitive psychology, computer display systems and the process being controlled

General multiplex centralized fire-alarm display system

International Nuclear Information System (INIS)

Zhu Liqun; Chen Jinming

2002-01-01

The fire-alarm display system is developed, which can connect with each type of fire controllers produced in the factory and SIGMASYS controllers. It can display whole alarm information. The display system software gathers communication, database and multimedia, has functions of inspecting fire, showing alarm, storing data, searching information and so on. The drawing software lets the user expediently add, delete, move and modify fire detection or fire fighting facilities on the building floor maps. The graphic transform software lets the display use the vectorgraph produced by popular plotting software such as Auto CAD. The system software provides the administration function, such as log book of changing shift and managing workers etc.. The software executed on Windows 98 platform. The user interface is friendly and reliable in operation

Software Development for Remote Control and Firing Room Displays

Science.gov (United States)

Zambrano Pena, Jessica

2014-01-01

The Launch Control System (LCS) developed at NASA's Kennedy Space Center (KSC) will be used to launch future spacecraft. Two of the many components of this system are the Application Control Language (ACL) and remote displays. ACL is a high level domain specific language that is used to write remote control applications for LCS. Remote displays are graphical user interfaces (GUIs) developed to display vehicle and Ground Support Equipment (GSE) data, they also provide the ability to send commands to control GSE and the vehicle. The remote displays and the control applications have many facets and this internship experience dealt with several of them.

AMDLIBGZ, IBM 360 Subroutine Library for Data Processing, Graphics, Sorting

International Nuclear Information System (INIS)

Wang, Jesse Y.

1980-01-01

Description of problem or function: AMDLIBGZ is a subset of the IBM 360 Subroutine Library at the Applied Mathematics Division at Argonne National Laboratory. This subset includes library categories G-Z: Identification/Description: G552S F RANF: Random number generator; J952S F YOLYPLOT: CalComp plots; J955S P GRAF: Prints a graph of points on line printer; K250S A1: Core to core conversion; K251S A HEXINP: Hexadecimal input for PL/I programs; K252S A HEXOUT: Hexadecimal output conv. PL/I programs; M101S F SORT: Algebraic sort; M150S F CSORT: Algebraic sort; M151S P2 ANLKWIC: KWIC sort; M250S A SMALLIST: Squeezes assembler listing to 8 x 11; N251S A ABEND: Calls ABEND dump; Q052S A CLOCK: Time; Q053S A COPYAGO: Copy load module from tape to disk; Q054S A DATE: Current date in form MM/DD/YY; Q055S A TIME: Time (24 hour clock) in EBCDIC HH.MM.SS; Z013S F: Variable metric minimization; Z057S A LOCF: Locate machine addresses of variables; Z071S A ALLOC: Allocate LCS for FORTRAN programs; Z074S A ANLMNP: Exponent and mantissa manipulative functs.

Lambda-Display: A Powerful Tool for Antigen Discovery

Directory of Open Access Journals (Sweden)

Nicola Gargano

2011-04-01

Full Text Available Since its introduction in 1985, phage display technology has been successfully used in projects aimed at deciphering biological processes and isolating molecules of practical value in several applications. Bacteriophage lambda, representing a classical molecular cloning and expression system has also been exploited for generating large combinatorial libraries of small peptides and protein domains exposed on its capsid. More recently, lambda display has been consistently and successfully employed for domain mapping, antigen discovery and protein interaction studies or, more generally, in functional genomics. We show here the results obtained by the use of large libraries of cDNA and genomic DNA for the molecular dissection of the human B-cell response against complex pathogens, including protozoan parasites, bacteria and viruses. Moreover, by reviewing the experimental work performed in recent investigations we illustrate the potential of lambda display in the diagnostics field and for identifying antigens useful as targets for vaccine development.

The Library use Patterns of Secondary School Students in Bomo ...

African Journals Online (AJOL)

... and the findings and implications are reported the major finding of the study is that students can only display a remarkable disposition to use the school library when bibliographic guidance is provided and classroom instnlction is integrated with school library resources. The role of teachers and librarians in creating library ...

Volumetric three-dimensional display system with rasterization hardware

Science.gov (United States)

Favalora, Gregg E.; Dorval, Rick K.; Hall, Deirdre M.; Giovinco, Michael; Napoli, Joshua

2001-06-01

An 8-color multiplanar volumetric display is being developed by Actuality Systems, Inc. It will be capable of utilizing an image volume greater than 90 million voxels, which we believe is the greatest utilizable voxel set of any volumetric display constructed to date. The display is designed to be used for molecular visualization, mechanical CAD, e-commerce, entertainment, and medical imaging. As such, it contains a new graphics processing architecture, novel high-performance line- drawing algorithms, and an API similar to a current standard. Three-dimensional imagery is created by projecting a series of 2-D bitmaps ('image slices') onto a diffuse screen that rotates at 600 rpm. Persistence of vision fuses the slices into a volume-filling 3-D image. A modified three-panel Texas Instruments projector provides slices at approximately 4 kHz, resulting in 8-color 3-D imagery comprised of roughly 200 radially-disposed slices which are updated at 20 Hz. Each slice has a resolution of 768 by 768 pixels, subtending 10 inches. An unusual off-axis projection scheme incorporating tilted rotating optics is used to maintain good focus across the projection screen. The display electronics includes a custom rasterization architecture which converts the user's 3- D geometry data into image slices, as well as 6 Gbits of DDR SDRAM graphics memory.

Synthesis and screening of peptide libraries with free C-termini.

Science.gov (United States)

Wang, Yen-Chih; Distefano, Mark D

2014-01-01

Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating peptide libraries using either solid-phase peptide synthesis or phage display are described. Methods for screening such libraries and their application in studying several important biological problems are also reported.

Consed: a graphical editor for next-generation sequencing.

Science.gov (United States)

Gordon, David; Green, Phil

2013-11-15

The rapid growth of DNA sequencing throughput in recent years implies that graphical interfaces for viewing and correcting errors must now handle large numbers of reads, efficiently pinpoint regions of interest and automate as many tasks as possible. We have adapted consed to reflect this. To allow full-feature editing of large datasets while keeping memory requirements low, we developed a viewer, bamScape, that reads billion-read BAM files, identifies and displays problem areas for user review and launches the consed graphical editor on user-selected regions, allowing, in addition to longstanding consed capabilities such as assembly editing, a variety of new features including direct editing of the reference sequence, variant and error detection, display of annotation tracks and the ability to simultaneously process a group of reads. Many batch processing capabilities have been added. The consed package is free to academic, government and non-profit users, and licensed to others for a fee by the University of Washington. The current version (26.0) is available for linux, macosx and solaris systems or as C++ source code. It includes a user's manual (with exercises) and example datasets. http://www.phrap.org/consed/consed.html dgordon@uw.edu .

LookOnX: A new technological approach for the H1 off-line event display

International Nuclear Information System (INIS)

Perus, A.; Arnault, C.

1994-01-01

The authors present the re-engineering work achieved on a traditional-fashioned GKS graphical package with new open-quotes event drivenclose quotes concepts required by using workstation interactivity. The Off-line Event Display for the H1 experiment H1look was originally written using a basic kernel package - Look - that provides a uniform control engine for graphical modules based on conventional GKS graphics. The use of powerful UNIX workstations is growing daily and their new graphical functionalities and CPU power are well suited to interactive graphical data analysis. Therefore re-engineering work was needed to put in some new features such as: interactive manipulations of graphical objects; object oriented definitions of the graphical representations and connectivity between graphical objects and physical objects; multi-windowing facility

galario: Gpu Accelerated Library for Analyzing Radio Interferometer Observations

Science.gov (United States)

Tazzari, Marco; Beaujean, Frederik; Testi, Leonardo

2017-10-01

The galario library exploits the computing power of modern graphic cards (GPUs) to accelerate the comparison of model predictions to radio interferometer observations. It speeds up the computation of the synthetic visibilities given a model image (or an axisymmetric brightness profile) and their comparison to the observations.

GOKaRT: Graphical Online Search Tool for Maps

Directory of Open Access Journals (Sweden)

Mechthild Schüler

2008-09-01

Full Text Available The map department of the Staats- und Universitätsbibliothek Göttingen together with the Berlin State Library propose a project to develop a web-based graphic cataloguing and search system for maps, to be funded by the German Research Foundation. This tool shall be made available to all map holdings in archives, libraries, university departments and museums in Germany as a comfortable means for the administration of map holdings and as a search tool. Sheets belonging to map series as well as single maps (old and new will be registered cooperatively by the participants with simple tools. This cooperation in data maintenance will facilitate the work especially for understaffed map holdings. Depending on the type of map there are four different mechanisms for map reference. For map series electronic index sheets are used which will show information regarding the various issues of the map sheets. Due to the intuitive graphic search entry GOKaRT-users will easily find the required maps of a certain region available in a chosen holding. User administration modules ensure comfortable handling. GOKaRT is being developed on the basis of licence-free open source programmes. In case financing is provided by the German Research Foundation, GOKaRT can be used free of charge internationally. This would require a contract stipulating data exchange between the partners as well as permanent storage and usability of the data.

Energy, mass, model-based displays, and memory recall

International Nuclear Information System (INIS)

Beltracchi, L.

1989-01-01

The operation of a pressurized water reactor in the context of the conservation laws for energy and mass is discussed. These conservation laws are the basis of the Rankine heat engine cycle. Computer graphic implementation of the heat engine cycle, in terms of temperature-entropy coordinates for water, serves as a model-based display of the plant process. A human user of this display, trained in first principles of the process, may exercise a monitoring strategy based on the conservation laws

Screening for single-chain variable fragment antibodies against multiple Cry1 toxins from an immunized mouse phage display antibody library.

Science.gov (United States)

Dong, Sa; Bo, Zongyi; Zhang, Cunzheng; Feng, Jianguo; Liu, Xianjin

2018-04-01

Single-chain variable fragment (scFv) is a kind of antibody that possess only one chain of the complete antibody while maintaining the antigen-specific binding abilities and can be expressed in prokaryotic system. In this study, scFvs against Cry1 toxins were screened out from an immunized mouse phage displayed antibody library, which was successfully constructed with capacity of 6.25 × 10 7  CFU/mL. Using the mixed and alternative antigen coating strategy and after four rounds of affinity screening, seven positive phage-scFvs against Cry1 toxins were selected and characterized. Among them, clone scFv-3H9 (MG214869) showing relative stable and high binding abilities to six Cry1 toxins was selected for expression and purification. SDS-PAGE indicated that the scFv-3H9 fragments approximately 27 kDa were successfully expressed in Escherichia coli HB2151 strain. The purified scFv-3H9 was used to establish the double antibody sandwich enzyme-linked immunosorbent assay method (DAS-ELISA) for detecting six Cry1 toxins, of which the lowest detectable limits (LOD) and the lowest quantitative limits (LOQ) were 3.14-11.07 and 8.22-39.44 ng mL -1 , respectively, with the correlation coefficient higher than 0.997. The average recoveries of Cry1 toxins from spiked rice leaf samples were ranged from 84 to 95%, with coefficient of variation (CV) less than 8.2%, showing good accuracy for the multi-residue determination of six Cry1 toxins in agricultural samples. This research suggested that the constructed phage display antibody library based on the animal which was immunized with the mixture of several antigens under the same category can be used for the quick and effective screening of generic antibodies.

Concurrent use of data base and graphics computer workstations to provide graphic access to large, complex data bases for robotics control of nuclear surveillance and maintenance

International Nuclear Information System (INIS)

Dalton, G.R.; Tulenko, J.S.; Zhou, X.

1990-01-01

The University of Florida is part of a multiuniversity research effort, sponsored by the US Department of Energy which is under way to develop and deploy an advanced semi-autonomous robotic system for use in nuclear power stations. This paper reports on the development of the computer tools necessary to gain convenient graphic access to the intelligence implicit in a large complex data base such as that in a nuclear reactor plant. This program is integrated as a man/machine interface within the larger context of the total computerized robotic planning and control system. The portion of the project described here addresses the connection between the three-dimensional displays on an interactive graphic workstation and a data-base computer running a large data-base server program. Programming the two computers to work together to accept graphic queries and return answers on the graphic workstation is a key part of the interactive capability developed

Efficient identification of phosphatidylserine-binding proteins by ORF phage display

International Nuclear Information System (INIS)

Caberoy, Nora B.; Zhou, Yixiong; Alvarado, Gabriela; Fan, Xianqun; Li, Wei

2009-01-01

To efficiently elucidate the biological roles of phosphatidylserine (PS), we developed open-reading-frame (ORF) phage display to identify PS-binding proteins. The procedure of phage panning was optimized with a phage clone expressing MFG-E8, a well-known PS-binding protein. Three rounds of phage panning with ORF phage display cDNA library resulted in ∼300-fold enrichment in PS-binding activity. A total of 17 PS-binding phage clones were identified. Unlike phage display with conventional cDNA libraries, all 17 PS-binding clones were ORFs encoding 13 real proteins. Sequence analysis revealed that all identified PS-specific phage clones had dimeric basic amino acid residues. GST fusion proteins were expressed for 3 PS-binding proteins and verified for their binding activity to PS liposomes, but not phosphatidylcholine liposomes. These results elucidated previously unknown PS-binding proteins and demonstrated that ORF phage display is a versatile technology capable of efficiently identifying binding proteins for non-protein molecules like PS.

CARL Corporation to Market Knight Ridder DIALOG Databases to the Academic and Public Library Market.

Science.gov (United States)

Machovec, George S.

1996-01-01

With the advent of CD-ROMs, libraries began to limit online searching via DIALOG. To increase DIALOG's market share, Colorado Alliance of Research Libraries (CARL) Corporation is developing graphical user interfaces using World Wide Web and Windows technology and has reached agreements with Knight Ridder Information and with most of their database…

Real-time radar signal processing using GPGPU (general-purpose graphic processing unit)

Science.gov (United States)

Kong, Fanxing; Zhang, Yan Rockee; Cai, Jingxiao; Palmer, Robert D.

2016-05-01

This study introduces a practical approach to develop real-time signal processing chain for general phased array radar on NVIDIA GPUs(Graphical Processing Units) using CUDA (Compute Unified Device Architecture) libraries such as cuBlas and cuFFT, which are adopted from open source libraries and optimized for the NVIDIA GPUs. The processed results are rigorously verified against those from the CPUs. Performance benchmarked in computation time with various input data cube sizes are compared across GPUs and CPUs. Through the analysis, it will be demonstrated that GPGPUs (General Purpose GPU) real-time processing of the array radar data is possible with relatively low-cost commercial GPUs.

Three-dimensional display of the pelvic viscera using multi-sliced MR images

International Nuclear Information System (INIS)

Ueno, Shigeru; Suto, Yasuzo.

1995-01-01

Accurate reconstruction of the pelvic structure is the most important factor to obtain desirable results after anorectal surgery. Preoperative evaluation of the anatomy is indispensable for choosing an appropriate operative method in each case. To facilitate the preoperative evaluation, three dimensional images of the pelvic structure of patients with anorectal malformations were constructed by computer graphics based upon two dimensional images obtained from MR-CT. Graphic data from MR images were transferred to a graphic work station. The anorectum, bladder and sphincter musculature were displayed three-dimensionally after segmenting these organs by (1) manually regioning the area containing the specific organ and (2) thresholding the area by the T 1 intensity level. The anatomy of each type of anomaly is easily recognized by the 3-D visualization of pelvic viscera and sphincter musculature with emphasis on position and shape of the musculature although there are some difficulties to visualize soft tissue organs. The advanced programs could show the graphic images from any desirable angle quickly enough to be helpful for the simulation of the surgery. Three-dimensional display can be very useful for better understanding of each anomaly and determining the operative method prior to surgery. (author)

USGS library for S-PLUS for Windows -- Release 4.0

Science.gov (United States)

Lorenz, David L.; Ahearn, Elizabeth A.; Carter, Janet M.; Cohn, Timothy A.; Danchuk, Wendy J.; Frey, Jeffrey W.; Helsel, Dennis R.; Lee, Kathy E.; Leeth, David C.; Martin, Jeffrey D.; McGuire, Virginia L.; Neitzert, Kathleen M.; Robertson, Dale M.; Slack, James R.; Starn, J. Jeffrey; Vecchia, Aldo V.; Wilkison, Donald H.; Williamson, Joyce E.

2011-01-01

Release 4.0 of the U.S. Geological Survey S-PLUS library supercedes release 2.1. It comprises functions, dialogs, and datasets used in the U.S. Geological Survey for the analysis of water-resources data. This version does not contain ESTREND, which was in version 2.1. See Release 2.1 for information and access to that version. This library requires Release 8.1 or later of S-PLUS for Windows. S-PLUS is a commercial statistical and graphical analysis software package produced by TIBCO corporation(http://www.tibco.com/). The USGS library is not supported by TIBCO or its technical support staff.

Crystal ball single event display

International Nuclear Information System (INIS)

Grosnick, D.; Gibson, A.; Allgower, C.; Alyea, J.; Argonne National Lab., IL

1997-01-01

The Single Event Display (SED) is a routine that is designed to provide information graphically about a triggered event within the Crystal Ball. The SED is written entirely in FORTRAN and uses the CERN-based HICZ graphing package. The primary display shows the amount of energy deposited in each of the NaI crystals on a Mercator-like projection of the crystals. Ten different shades and colors correspond to varying amounts of energy deposited within a crystal. Information about energy clusters is displayed on the crystal map by outlining in red the thirteen (or twelve) crystals contained within a cluster and assigning each cluster a number. Additional information about energy clusters is provided in a series of boxes containing useful data about the energy distribution among the crystals within the cluster. Other information shown on the event display include the event trigger type and data about π o 's and η's formed from pairs of clusters as found by the analyzer. A description of the major features is given, along with some information on how to install the SED into the analyzer

Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries.

Science.gov (United States)

Nuttall, S D; Krishnan, U V; Hattarki, M; De Gori, R; Irving, R A; Hudson, P J

2001-08-01

The new antigen receptor (NAR) from nurse sharks consists of an immunoglobulin variable domain attached to five constant domains, and is hypothesised to function as an antigen-binding antibody-like molecule. To determine whether the NAR is present in other species we have isolated a number of new antigen receptor variable domains from the spotted wobbegong shark (Orectolobus maculatus) and compared their structure to that of the nurse shark protein. To determine whether these wNARs can function as antigen-binding proteins, we have used them as scaffolds for the construction of protein libraries in which the CDR3 loop was randomised, and displayed the resulting recombinant domains on the surface of fd bacteriophages. On selection against several protein antigens, the highest affinity wNAR proteins were generated against the Gingipain K protease from Porphyromonas gingivalis. One wNAR protein bound Gingipain K specifically by ELISA and BIAcore analysis and, when expressed in E. coli and purified by affinity chromatography, eluted from an FPLC column as a single peak consistent with folding into a monomeric protein. Naturally occurring nurse shark and wobbegong NAR variable domains exhibit conserved cysteine residues within the CDR1 and CDR3 loops which potentially form disulphide linkages and enhance protein stability; proteins isolated from the in vitro NAR wobbegong library showed similar selection for such paired cysteine residues. Thus, the New Antigen Receptor represents a protein scaffold with possible stability advantages over conventional antibodies when used in in vitro molecular libraries.

The effect of a graphical interpretation of a statistic trend indicator (Trigg's Tracking Variable) on the detection of simulated changes.

Science.gov (United States)

Kennedy, R R; Merry, A F

2011-09-01

Anaesthesia involves processing large amounts of information over time. One task of the anaesthetist is to detect substantive changes in physiological variables promptly and reliably. It has been previously demonstrated that a graphical trend display of historical data leads to more rapid detection of such changes. We examined the effect of a graphical indication of the magnitude of Trigg's Tracking Variable, a simple statistically based trend detection algorithm, on the accuracy and latency of the detection of changes in a micro-simulation. Ten anaesthetists each viewed 20 simulations with four variables displayed as the current value with a simple graphical trend display. Values for these variables were generated by a computer model, and updated every second; after a period of stability a change occurred to a new random value at least 10 units from baseline. In 50% of the simulations an indication of the rate of change was given by a five level graphical representation of the value of Trigg's Tracking Variable. Participants were asked to indicate when they thought a change was occurring. Changes were detected 10.9% faster with the trend indicator present (mean 13.1 [SD 3.1] cycles vs 14.6 [SD 3.4] cycles, 95% confidence interval 0.4 to 2.5 cycles, P = 0.013. There was no difference in accuracy of detection (median with trend detection 97% [interquartile range 95 to 100%], without trend detection 100% [98 to 100%]), P = 0.8. We conclude that simple statistical trend detection may speed detection of changes during routine anaesthesia, even when a graphical trend display is present.

Does the lead white on graphic art have a dark future?

DEFF Research Database (Denmark)

Vila, Anna; Ryhl-Svendsen, Morten; Buti, David

in the formation of lead sulphide (galena, PbS) [3]. Although the galena is the most frequently found degradation product associated to lead carbonate, brown lead dioxide (plattnerite, PbO2) can also be detected. Records from the last ten years on the Statens Museum for Kunst (SMK) graphic art collection revealed...... the formation, in a very short time, of different types of dark spots on the lead white highlights. A recent systematic survey at SMK and the Danish Royal Library (RL) mapped the occurrence and degree of degradation on graphic art and photography and allowed to classify the lead white phenomena. Watercolor mock......, D., et al., Spectroscopic studies on the darkening of lead white. Applied spectroscopy, 2003. 57(11): p. 1393-1398....

INDL/V. IAEA Nuclear Data Library for various neutron data evaluations in ENDF/B-5 format

International Nuclear Information System (INIS)

Pronyaev, V.; Cullen, D.; Lemmel, H.D.; McLaughlin, K.; Schwerer, O.

1982-05-01

INDL/V is a computerized library for evaluated neutron reaction data of varying origin compiled in ENDF/B-5 format. The data are available costfree on magnetic tape from the IAEA Nuclear Data Section. This document summarizes the contents of the library, including graphical plots of all cross-section data. (author)

The development of graphic simulation technology for tele-operated robot

International Nuclear Information System (INIS)

Kim, Chang Hoi; Kim, Seung Ho; Kim, Ki Ho; Jung, Seung Ho; Hwang, Suk Yeoung; Kim, Byung Soo; Seo, Yong Chil; Lee, Young Kwang

1998-02-01

In hostile environments like a nuclear power plant, human access is limited to the strict minimum due to the high-level of radiation. The design of tele-robotic system requires careful preparation because of the nature of its safety. Also, the human operator should have a capability of supervising the robot system and responding promptly to the unexpected events. In this study, the graphic simulation technology has been developed to construct tele-robotic system which can effectively perform the specified tasks in nuclear facilities. The developed graphic simulator utilizes the Indigo 2 workstation of Silicon Graphics as a main computer and its software is written in the OpenGL graphic library in X windows environments. The developed simulator, interfaced with the control system of the real robot through the ethernet, acts as a supervisory controller. Since clear and concise visual information on real robot posture and task environments can be processed in real time, the efficiency of tele-operation can be remarkably enhanced with this simulator. This simulator using advanced 3 dimensional graphics has many advantages of modeling complicated shapes of robot and constructing the virtual work environments similar to the real ones. With the use of this developed simulator, the operator can evaluate the performance of the tele-robot before it is put into real operation. This system can prevents the possible disaster of the robot resulting from the collision with its work environments. (author). 9 refs., 23 tabs., 13 figs

Animated graphics for comparing two risks: a cautionary tale.

Science.gov (United States)

Zikmund-Fisher, Brian J; Witteman, Holly O; Fuhrel-Forbis, Andrea; Exe, Nicole L; Kahn, Valerie C; Dickson, Mark

2012-07-25

The increasing use of computer-administered risk communications affords the potential to replace static risk graphics with animations that use motion cues to reinforce key risk messages. Research on the use of animated graphics, however, has yielded mixed findings, and little research exists to identify the specific animations that might improve risk knowledge and patients' decision making. To test whether viewing animated forms of standard pictograph (icon array) risk graphics displaying risks of side effects would improve people's ability to select the treatment with the lowest risk profile, as compared with viewing static images of the same risks. A total of 4198 members of a demographically diverse Internet panel read a scenario about two hypothetical treatments for thyroid cancer. Each treatment was described as equally effective but varied in side effects (with one option slightly better than the other). Participants were randomly assigned to receive all risk information in 1 of 10 pictograph formats in a quasi-factorial design. We compared a control condition of static grouped icons with a static scattered icon display and with 8 Flash-based animated versions that incorporated different combinations of (1) building the risk 1 icon at a time, (2) having scattered risk icons settle into a group, or (3) having scattered risk icons shuffle themselves (either automatically or by user control). We assessed participants' ability to choose the better treatment (choice accuracy), their gist knowledge of side effects (knowledge accuracy), and their graph evaluation ratings, controlling for subjective numeracy and need for cognition. When compared against static grouped-icon arrays, no animations significantly improved any outcomes, and most showed significant performance degradations. However, participants who received animations of grouped icons in which at-risk icons appeared 1 at a time performed as well on all outcomes as the static grouped-icon control group

COREMAP - Graphical User Interface for displaying reactor core data in an interactive hexagonal map

International Nuclear Information System (INIS)

Muscat, F.L.; Derstine, K.L.

1995-01-01

COREMAP displays reactor core data from multidimensional neutronic simulation models in color and/or as text in an interactive 2D planar grid of hexagonal subassemblies. The interactive (point and click) interface enables the user to access multi data set files (e.g.. planes, moments, energy groups, ...) and to display up to two data sets simultaneously, one as text and the other as color. The user (1) controls color scale characteristics (linear or logarithmic) with a variety of range limits, (2) chooses zoom features (map size, ring number and surrounding subassemblies), (3) is supplied with popup sub-windows to display data from planes and energy groups currently offscreen for the selected cell. Three color scale shading techniques may be used to display data on any bitmapped screen monitor. Most effective displays are obtained with shades of blue and red on color monitors, shades of grey on greyscale monitors or stipple patterns on monochrome monitors. A fully automated printing option creates high quality PostScript color or greyscale images of the core map independent of the monitor used, e.g. color prints can be generated with a session from a monochrome monitor

Graphical Derivatives and Stability Analysis for Parameterized Equilibria with Conic Constraints

Czech Academy of Sciences Publication Activity Database

Mordukhovich, B. S.; Outrata, Jiří; Ramírez, H. C.

2015-01-01

Roč. 23, č. 4 (2015), s. 687-704 ISSN 1877-0533 R&D Projects: GA ČR(CZ) GAP201/12/0671 Institutional support: RVO:67985556 Keywords : Variational analysis and optimization * Parameterized equilibria * Conic constraints * Sensitivity and stability analysis * Solution maps * Graphical derivatives * Normal and tangent cones Subject RIV: BA - General Mathematics Impact factor: 0.973, year: 2015 http://library.utia.cas.cz/separaty/2015/MTR/outrata-0449259.pdf

A High Performance VLSI Computer Architecture For Computer Graphics

Science.gov (United States)

Chin, Chi-Yuan; Lin, Wen-Tai

1988-10-01

A VLSI computer architecture, consisting of multiple processors, is presented in this paper to satisfy the modern computer graphics demands, e.g. high resolution, realistic animation, real-time display etc.. All processors share a global memory which are partitioned into multiple banks. Through a crossbar network, data from one memory bank can be broadcasted to many processors. Processors are physically interconnected through a hyper-crossbar network (a crossbar-like network). By programming the network, the topology of communication links among processors can be reconfigurated to satisfy specific dataflows of different applications. Each processor consists of a controller, arithmetic operators, local memory, a local crossbar network, and I/O ports to communicate with other processors, memory banks, and a system controller. Operations in each processor are characterized into two modes, i.e. object domain and space domain, to fully utilize the data-independency characteristics of graphics processing. Special graphics features such as 3D-to-2D conversion, shadow generation, texturing, and reflection, can be easily handled. With the current high density interconnection (MI) technology, it is feasible to implement a 64-processor system to achieve 2.5 billion operations per second, a performance needed in most advanced graphics applications.

NLEdit: A generic graphical user interface for Fortran programs

Science.gov (United States)

Curlett, Brian P.

1994-01-01

NLEdit is a generic graphical user interface for the preprocessing of Fortran namelist input files. The interface consists of a menu system, a message window, a help system, and data entry forms. A form is generated for each namelist. The form has an input field for each namelist variable along with a one-line description of that variable. Detailed help information, default values, and minimum and maximum allowable values can all be displayed via menu picks. Inputs are processed through a scientific calculator program that allows complex equations to be used instead of simple numeric inputs. A custom user interface is generated simply by entering information about the namelist input variables into an ASCII file. There is no need to learn a new graphics system or programming language. NLEdit can be used as a stand-alone program or as part of a larger graphical user interface. Although NLEdit is intended for files using namelist format, it can be easily modified to handle other file formats.

True Stories of Censorship Battles in America's Libraries

Science.gov (United States)

Nye, Valerie, Ed.; Barco, Kathy, Ed.

2012-01-01

Intellectual freedom is a core value of librarianship, but fighting to keep controversial materials on the shelves can sometimes feel like a lonely battle. And not all censorship controversies involve the public objecting to a book in the collection--libraries are venues for displays and meetings, and sometimes library staff themselves are tempted…

The mzqLibrary--An open source Java library supporting the HUPO-PSI quantitative proteomics standard.

Science.gov (United States)

Qi, Da; Zhang, Huaizhong; Fan, Jun; Perkins, Simon; Pisconti, Addolorata; Simpson, Deborah M; Bessant, Conrad; Hubbard, Simon; Jones, Andrew R

2015-09-01

The mzQuantML standard has been developed by the Proteomics Standards Initiative for capturing, archiving and exchanging quantitative proteomic data, derived from mass spectrometry. It is a rich XML-based format, capable of representing data about two-dimensional features from LC-MS data, and peptides, proteins or groups of proteins that have been quantified from multiple samples. In this article we report the development of an open source Java-based library of routines for mzQuantML, called the mzqLibrary, and associated software for visualising data called the mzqViewer. The mzqLibrary contains routines for mapping (peptide) identifications on quantified features, inference of protein (group)-level quantification values from peptide-level values, normalisation and basic statistics for differential expression. These routines can be accessed via the command line, via a Java programming interface access or a basic graphical user interface. The mzqLibrary also contains several file format converters, including import converters (to mzQuantML) from OpenMS, Progenesis LC-MS and MaxQuant, and exporters (from mzQuantML) to other standards or useful formats (mzTab, HTML, csv). The mzqViewer contains in-built routines for viewing the tables of data (about features, peptides or proteins), and connects to the R statistical library for more advanced plotting options. The mzqLibrary and mzqViewer packages are available from https://code.google.com/p/mzq-lib/. © 2015 The Authors. PROTEOMICS Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Ergonomic design of an overview display in a nuclear power plant control room. Integrated process status overview

International Nuclear Information System (INIS)

Bouwmeester, R.

1996-03-01

A major modification of the Borssele Nuclear Power Plant (NPP), scheduled in 1997, includes the installation of a new Integrated Process Status Overview (IPSO) display in the extensively modified control room. The IPSO display is to promote effective communications among all individuals present in the control room with a clear overview of the main process systems. The flexible LCD rear-projection technique is selected for the replacement of the existing IPSO display with engraved process symbols and hard-wired LEDs. The relation between the IPSO display and the CRT based Process Presentation System (PPS) is described after an elaborate introduction to the nuclear technology and the modification project. The followed IPSO design methodology includes interviews with all IPSO user groups to acquire their experience and comment on the current IPSO in order to enhance the functionality and the acceptance of the new IPSO graphics. The ergonomic design requirements for the new IPSO display concern both generic aspects of information presentation on human-machine interfaces, as well as specific issues related to the selected LCD rear-projection technique. Intermediate stages in the design of the IPSO graphics are outlined as well as the results of the concept evaluation by the user groups. For special interest the functionality of a three dimensional (3-D) display was explored. The design study concludes with a 'final' IPSO graphics design to be used for evaluations on the control room simulator. The presentation of one graphic was found to be most appropriate with adjustment of colour (grey) of components and systems which do not need to operate during the current process conditions or plant mode. (orig.)

The virtual library: Coming of age

Science.gov (United States)

Hunter, Judy F.; Cotter, Gladys A.

1994-01-01

With the high speed networking capabilities, multiple media options, and massive amounts of information that exist in electronic format today, the concept of a 'virtual' library or 'library without walls' is becoming viable. In virtual library environment, the information processed goes beyond the traditional definition of documents to include the results of scientific and technical research and development (reports, software, data) recorded in any format or media: electronic, audio, video, or scanned images. Network access to information must include tools to help locate information sources and navigate the networks to connect to the sources, as well as methods to extract the relevant information. Graphical User Interfaces (GUI's) that are intuitive and navigational tools such as Intelligent Gateway Processors (IGP) will provide users with seamless and transparent use of high speed networks to access, organize, and manage information. Traditional libraries will become points of electronic access to information on multiple medias. The emphasis will be towards unique collections of information at each library rather than entire collections at every library. It is no longer a question of whether there is enough information available; it is more a question of how to manage the vast volumes of information. The future equation will involve being able to organize knowledge, manage information, and provide access at the point of origin.

Delin and Delog codes for graphic representation of gamma ray spectra

International Nuclear Information System (INIS)

Travesi, A.; Romero, L.

1983-01-01

Two FORTRAN IV Codes have been developed for graphic representation of the gamma-ray spectra obtained with GeLi detectors and multichannel analyzers. The graphic plotting is carried out with the H.P. Graphic Plotter Mod HP-7221 A, using the graphic package software GRAPHICS-1000 from Hewlett-Packard. The codes have a great versatility and the representation of gamma spectra can be done in a lineal, semilog, or log-log scale, as desired. The gamma ray spectra data are fed into the computer through magnetic tape or perforated paper tape. The different output options and complementary data are given in a conversational way through a terminal with TV display. Among the options that can be selected by the user are the following: 1) smoothing the spectra; 2) drawing the spectra point by point or continuous; 3) output drawing in 1, 2 or 4 sheets with automatic division of the energy scale; 4) overlapping of selected spectra regions in γ-scale ampliation with automatic printout of the region limits and ampliation factor; 5) printing spectra data and identifications of selected photopeaks. The codes can be employed with any computer using printing devices, HP-GRAPHICS 1000 software compatible, but are easily modified for another printing software since their modular structure with FORTRAN IV written subroutines. (author)

A manned maneuvering unit proximity operations planning and flight guidance display and control system

Science.gov (United States)

Gershzohn, Gary R.; Sirko, Robert J.; Zimmerman, K.; Jones, A. D.

1990-01-01

This task concerns the design, development, testing, and evaluation of a new proximity operations planning and flight guidance display and control system for manned space operations. A forecast, derivative manned maneuvering unit (MMU) was identified as a candidate for the application of a color, highway-in-the-sky display format for the presentation of flight guidance information. A silicon graphics 4D/20-based simulation is being developed to design and test display formats and operations concepts. The simulation includes the following: (1) real-time color graphics generation to provide realistic, dynamic flight guidance displays and control characteristics; (2) real-time graphics generation of spacecraft trajectories; (3) MMU flight dynamics and control characteristics; (4) control algorithms for rotational and translational hand controllers; (5) orbital mechanics effects for rendezvous and chase spacecraft; (6) inclusion of appropriate navigation aids; and (7) measurement of subject performance. The flight planning system under development provides for: (1) selection of appropriate operational modes, including minimum cost, optimum cost, minimum time, and specified ETA; (2) automatic calculation of rendezvous trajectories, en route times, and fuel requirements; (3) and provisions for manual override. Man/machine function allocations in planning and en route flight segments are being evaluated. Planning and en route data are presented on one screen composed of two windows: (1) a map display presenting a view perpendicular to the orbital plane, depicting flight planning trajectory and time data attitude display presenting attitude and course data for use en route; and (2) an attitude display presenting local vertical-local horizontal attitude data superimposed on a highway-in-the-sky or flight channel representation of the flight planned course. Both display formats are presented while the MMU is en route. In addition to these displays, several original display

Real-time display of flow-pressure-volume loops.

Science.gov (United States)

Morozoff, P E; Evans, R W

1992-01-01

Graphic display of respiratory waveforms can be valuable for monitoring the progress of ventilated patients. A system has been developed that can display flow-pressure-volume loops as derived from a patient's respiratory circuit in real time. It can also display, store, print, and retrieve ventilatory waveforms. Five loops can be displayed at once: current, previous, reference, "ideal," and previously saved. Two components, the data-display device (DDD) and the data-collection device (DCD), comprise the system. An IBM 286/386 computer with a graphics card (VGA) and bidirectional parallel port is used for the DDD; an eight-bit microprocessor card and an A/D convertor card make up the DCD. A real-time multitasking operating system was written to control the DDD, while the DCD operates from in-line assembly code. The DCD samples the pressure and flow sensors at 100 Hz and looks for a complete flow waveform pattern based on flow slope. These waveforms are then passed to the DDD via the mutual parallel port. Within the DDD a process integrates the flow to create a volume signal and performs a multilinear regression on the pressure, flow, and volume data to calculate the elastance, resistance, pressure offset, and coefficient of determination. Elastance, resistance, and offset are used to calculate Pr and Pc where: Pr[k] = P[k]-offset-(elastance.V[k]) and Pc[k] = P[k]-offset-(resistance.F[k]). Volume vs. Pc and flow vs. Pr can be displayed in real time. Patient data from previous clinical tests were loaded into the device to verify the software calculations. An analog waveform generator was used to simulate flow and pressure waveforms that validated the system.(ABSTRACT TRUNCATED AT 250 WORDS)

General purpose graphic processing unit implementation of adaptive pulse compression algorithms

Science.gov (United States)

Cai, Jingxiao; Zhang, Yan

2017-07-01

This study introduces a practical approach to implement real-time signal processing algorithms for general surveillance radar based on NVIDIA graphical processing units (GPUs). The pulse compression algorithms are implemented using compute unified device architecture (CUDA) libraries such as CUDA basic linear algebra subroutines and CUDA fast Fourier transform library, which are adopted from open source libraries and optimized for the NVIDIA GPUs. For more advanced, adaptive processing algorithms such as adaptive pulse compression, customized kernel optimization is needed and investigated. A statistical optimization approach is developed for this purpose without needing much knowledge of the physical configurations of the kernels. It was found that the kernel optimization approach can significantly improve the performance. Benchmark performance is compared with the CPU performance in terms of processing accelerations. The proposed implementation framework can be used in various radar systems including ground-based phased array radar, airborne sense and avoid radar, and aerospace surveillance radar.

R graphics

CERN Document Server

Murrell, Paul

2005-01-01

R is revolutionizing the world of statistical computing. Powerful, flexible, and best of all free, R is now the program of choice for tens of thousands of statisticians. Destined to become an instant classic, R Graphics presents the first complete, authoritative exposition on the R graphical system. Paul Murrell, widely known as the leading expert on R graphics, has developed an in-depth resource that takes nothing for granted and helps both neophyte and seasoned users master the intricacies of R graphics. After an introductory overview of R graphics facilities, the presentation first focuses

Plots, Calculations and Graphics Tools (PCG2). Software Transfer Request Presentation

Science.gov (United States)

Richardson, Marilou R.

2010-01-01

This slide presentation reviews the development of the Plots, Calculations and Graphics Tools (PCG2) system. PCG2 is an easy to use tool that provides a single user interface to view data in a pictorial, tabular or graphical format. It allows the user to view the same display and data in the Control Room, engineering office area, or remote sites. PCG2 supports extensive and regular engineering needs that are both planned and unplanned and it supports the ability to compare, contrast and perform ad hoc data mining over the entire domain of a program's test data.

Graphical representation of objects' states for the PF linac control system

International Nuclear Information System (INIS)

Mejuev, I.; Abe, I.; Nakahara, K.

1995-01-01

This paper describes our approach for creating of a graphical representation of the states of accelerator objects. For every object which needs to display its state dynamics we create a chart element. Any changes in the object state are immediately represented on the chart of this object. We use the objects dependencies facility supplied by Smalltalk to keep track of the objects' states changes. This allows us to remove any graphics related features from the Object Model of the accelerator. Thus, the Object Model can be developed separately and reused in a number of applications. (author)

Avian leukosis virus is a versatile eukaryotic platform for polypeptide display

International Nuclear Information System (INIS)

Khare, Pranay D.; Russell, Stephen J.; Federspiel, Mark J.

2003-01-01

Display technology refers to methods of generating libraries of modularly coded biomolecules and screening them for particular properties. Retroviruses are good candidates to be a eukaryotic viral platform for the display of polypeptides synthesized in eukaryotic cells. Here we demonstrate that avian leukosis virus (ALV) provides an ideal platform for display of nonviral polyaeptides expressed in a eukaryotic cell substrate. Different sizes of polypeptides were genetically fused to the extreme N-terminus of the ALV envelope glycoprotein in an ALV infectious clone containing an alkaline phosphatase reporter gene. The chimeric envelope glycoproteins were efficiently incorporated into virions and were stably displayed on the surface of the virions through multiple virus replication cycles. The foreign polypeptides did not interfere with the attachment and entry functions of the underlying ALV envelope glycoproteins. The displayed polypeptides were fully functional and could efficiently mediate attachment of the recombinant viruses to their respective cognate receptors. This study demonstrates that ALV is an ideal display platform for the generation and selection of libraries of polypeptides where there is a need for expression, folding, and posttranslational modification in the endoplasmic reticulum of eukaryotic cells

IMAGE information monitoring and applied graphics software environment. Volume 4. Applications description

International Nuclear Information System (INIS)

Hallam, J.W.; Ng, K.B.; Upham, G.L.

1986-09-01

The EPRI Information Monitoring and Applied Graphics Environment (IMAGE) system is designed for 'fast proto-typing' of advanced concepts for computer-aided plant operations tools. It is a flexible software system which can be used for rapidly creating, dynamically driving and evaluating advanced operator aid displays. The software is written to be both host computer and graphic device independent. This four volume report includes an Executive Overview of the IMAGE package (Volume 1), followed by Software Description (Volume II), User's Guide (Volume III), and Description of Example Applications (Volume IV)

Can we be more Graphic about Graphic Design?

OpenAIRE

Vienne, Véronique

2012-01-01

Can you objectify a subjective notion? This is the question graphic designers must face when they talk about their work. Even though graphic design artifacts are omnipresent in our culture, graphic design is still an exceptionally ill-defined profession. This is one of the reasons design criticism is still a rudimentary discipline. No one knows for sure what is this thing we sometimes call “graphic communication” for lack of a better word–a technique my Webster’s dictionary describes as “the ...

GROPE-1: a computer display to the sense of feel

Energy Technology Data Exchange (ETDEWEB)

Batter, J J; Brooks, Jr, F P

1972-01-01

A computer display system was built and programmed that exerts programmable forces on the fingers as one moves a knob in a plane. The system includes a movable carriage, position sensors, mechanisms for converting computer outputs to forces, a visual graphic display, and, most important, the programs. A controlled experiment measured the utility of force output. Two groups were taught topics in elementary field theory and exercised with the computer displays. One group had force displayed to the hand as well as to the eye. The other had visual display only. The experiment was repeated with three different sets of students. The force-display groups performed significantly better in two of the three cases; in the third case, interest in the subject was low and this seems to account for low performance.

ESO Reflex: a graphical workflow engine for data reduction

Science.gov (United States)

Hook, Richard; Ullgrén, Marko; Romaniello, Martino; Maisala, Sami; Oittinen, Tero; Solin, Otto; Savolainen, Ville; Järveläinen, Pekka; Tyynelä, Jani; Péron, Michèle; Ballester, Pascal; Gabasch, Armin; Izzo, Carlo

ESO Reflex is a prototype software tool that provides a novel approach to astronomical data reduction by integrating a modern graphical workflow system (Taverna) with existing legacy data reduction algorithms. Most of the raw data produced by instruments at the ESO Very Large Telescope (VLT) in Chile are reduced using recipes. These are compiled C applications following an ESO standard and utilising routines provided by the Common Pipeline Library (CPL). Currently these are run in batch mode as part of the data flow system to generate the input to the ESO/VLT quality control process and are also exported for use offline. ESO Reflex can invoke CPL-based recipes in a flexible way through a general purpose graphical interface. ESO Reflex is based on the Taverna system that was originally developed within the UK life-sciences community. Workflows have been created so far for three VLT/VLTI instruments, and the GUI allows the user to make changes to these or create workflows of their own. Python scripts or IDL procedures can be easily brought into workflows and a variety of visualisation and display options, including custom product inspection and validation steps, are available. Taverna is intended for use with web services and experiments using ESO Reflex to access Virtual Observatory web services have been successfully performed. ESO Reflex is the main product developed by Sampo, a project led by ESO and conducted by a software development team from Finland as an in-kind contribution to joining ESO. The goal was to look into the needs of the ESO community in the area of data reduction environments and to create pilot software products that illustrate critical steps along the road to a new system. Sampo concluded early in 2008. This contribution will describe ESO Reflex and show several examples of its use both locally and using Virtual Observatory remote web services. ESO Reflex is expected to be released to the community in early 2009.

ESO Reflex: A Graphical Workflow Engine for Data Reduction

Science.gov (United States)

Hook, R.; Romaniello, M.; Péron, M.; Ballester, P.; Gabasch, A.; Izzo, C.; Ullgrén, M.; Maisala, S.; Oittinen, T.; Solin, O.; Savolainen, V.; Järveläinen, P.; Tyynelä, J.

2008-08-01

Sampo {http://www.eso.org/sampo} (Hook et al. 2005) is a project led by ESO and conducted by a software development team from Finland as an in-kind contribution to joining ESO. The goal is to assess the needs of the ESO community in the area of data reduction environments and to create pilot software products that illustrate critical steps along the road to a new system. Those prototypes will not only be used to validate concepts and understand requirements but will also be tools of immediate value for the community. Most of the raw data produced by ESO instruments can be reduced using CPL {http://www.eso.org/cpl} recipes: compiled C programs following an ESO standard and utilizing routines provided by the Common Pipeline Library. Currently reduction recipes are run in batch mode as part of the data flow system to generate the input to the ESO VLT/VLTI quality control process and are also made public for external users. Sampo has developed a prototype application called ESO Reflex {http://www.eso.org/sampo/reflex/} that integrates a graphical user interface and existing data reduction algorithms. ESO Reflex can invoke CPL-based recipes in a flexible way through a dedicated interface. ESO Reflex is based on the graphical workflow engine Taverna {http://taverna.sourceforge.net} that was originally developed by the UK eScience community, mostly for work in the life sciences. Workflows have been created so far for three VLT/VLTI instrument modes ( VIMOS/IFU {http://www.eso.org/instruments/vimos/}, FORS spectroscopy {http://www.eso.org/instruments/fors/} and AMBER {http://www.eso.org/instruments/amber/}), and the easy-to-use GUI allows the user to make changes to these or create workflows of their own. Python scripts and IDL procedures can be easily brought into workflows and a variety of visualisation and display options, including custom product inspection and validation steps, are available.

PAMLX: a graphical user interface for PAML.

Science.gov (United States)

Xu, Bo; Yang, Ziheng

2013-12-01

This note announces pamlX, a graphical user interface/front end for the paml (for Phylogenetic Analysis by Maximum Likelihood) program package (Yang Z. 1997. PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci. 13:555-556; Yang Z. 2007. PAML 4: Phylogenetic analysis by maximum likelihood. Mol Biol Evol. 24:1586-1591). pamlX is written in C++ using the Qt library and communicates with paml programs through files. It can be used to create, edit, and print control files for paml programs and to launch paml runs. The interface is available for free download at http://abacus.gene.ucl.ac.uk/software/paml.html.

Computerized three-dimensional treatment planning system utilizing interactive colour graphics

Energy Technology Data Exchange (ETDEWEB)

McShan, D L; Silverman, A; Lanza, D M; Reinstein, L E; Glicksman, A S [Rhode Island Hospital (US). Dept. of Radiation Oncology

1979-06-01

A new computerized radiation treatment planning system has been developed to aid in three-dimensional treatment planning. Using interactive colour graphics in conjunction with a PDP 11/45 computer, the system can take multiple transverse contours and construct a perspective display of the treatment region showing organ surfaces as well as cross-sectional contours. With interactively selected orientations, the display allows easy perception of the relative positioning of the treatment volume and the neighbouring anatomy. For external beam treatment planning, interactive computer simulation is used to select diaphragm sizes which best conform to the target area while avoiding sensitive structures. Dose calculations for the selected beams are carried out on multiple transverse planes. The calculational planes and surfaces are displayed in perspective with radiation dosage displayed in an interactively manipulated colour display. Altogether the system provides an easy assessment of the volume to be irradiated, interactive selection of optimal arrangements of treatment fields and a means of visualizing and evaluating the resulting dose distributions.

Upper Limb-Hand 3D Display System for Biomimetic Myoelectric Hand Simulator

National Research Council Canada - National Science Library

Jimenez, Gonzalo

2001-01-01

A graphics system displaying both upper limb posture and opening-closing of a prosthetic hand was developed for realtime operation of our biomimetic myoelectric hand simulator, Posture of the upper...

Versatile microbial surface-display for environmental remediation and biofuels production

Energy Technology Data Exchange (ETDEWEB)

Wu, Cindy H.; Mulchandani, Ashok; Chen, wilfred

2008-02-14

Surface display is a powerful technique that utilizes natural microbial functional components to express proteins or peptides on the cell exterior. Since the reporting of the first surface-display system in the mid-1980s, a variety of new systems have been reported for yeast, Gram-positive and Gram-negative bacteria. Non-conventional display methods are emerging, eliminating the generation of genetically modified microorganisms. Cells with surface display are used as biocatalysts, biosorbents and biostimulants. Microbial cell-surface display has proven to be extremely important for numerous applications ranging from combinatorial library screening and protein engineering to bioremediation and biofuels production.

Tests of Cumulative Prospect Theory with graphical displays of probability

Directory of Open Access Journals (Sweden)

Michael H. Birnbaum

2008-10-01

Full Text Available Recent research reported evidence that contradicts cumulative prospect theory and the priority heuristic. The same body of research also violates two editing principles of original prospect theory: cancellation (the principle that people delete any attribute that is the same in both alternatives before deciding between them and combination (the principle that people combine branches leading to the same consequence by adding their probabilities. This study was designed to replicate previous results and to test whether the violations of cumulative prospect theory might be eliminated or reduced by using formats for presentation of risky gambles in which cancellation and combination could be facilitated visually. Contrary to the idea that decision behavior contradicting cumulative prospect theory and the priority heuristic would be altered by use of these formats, however, data with two new graphical formats as well as fresh replication data continued to show the patterns of evidence that violate cumulative prospect theory, the priority heuristic, and the editing principles of combination and cancellation. Systematic violations of restricted branch independence also contradicted predictions of ``stripped'' prospect theory (subjectively weighted additive utility without the editing rules.

Display graphical information optimization methods in a client-server information system

Directory of Open Access Journals (Sweden)

Юрий Викторович Мазуревич

2015-07-01

Full Text Available This paper presents an approach to reduce load time and volume of data necessary to display web page due to server side preprocessing. Measurement of this approach’s effectivity has been conducted. There were discovered conditions in which this approach will be the most effective, its disadvantages and presented ways to reduce them

DPAK and HPAK: a versatile display and histogramming package

International Nuclear Information System (INIS)

Logg, C.A.; Boyarski, A.M.; Cook, A.J.; Cottrell, R.L.A.; Sund, S.

1979-07-01

The features of a display and histogram package which requires a minimal number of subroutine calls in order to generate graphic output in many flavors on a variety of devices are described. Default options are preset to values that are generally most wanted, but the default values may be readily changed to the user's needs. The description falls naturally into two parts, namely, the set of routines (DPAK) for displaying data on some device, and the set of routines (HPAK) for generating histograms. HPAK provides a means of allocating memory for histograms, accumulating data into histograms, and subsequently displaying the hisotgrams via calls to the DPAK routines. Histograms and displays of either one or two independent variables can be made

Testing the deGroot recall paradigm to evaluate displays for operating personnel

International Nuclear Information System (INIS)

Moray, N.; Jones, B.G.; Rasmussen, J.

1991-01-01

In this paper the authors report the results of experiments based on deGroot's work to assess the value of memory tests for measuring the quality of displays and the level of expertise of operators. Three kinds of display and people with three levels of expertise were included in the experiments. The displays were computer generated versions of traditional analog meters, traditional analog meters supplemented by a dynamic graphic representing the relation between temperature and pressure in some subsystems, and a dynamic graphic representing the underlying thermodynamics of power generation using the Rankine Cycle. The levels of expertise were represented by undergraduates with one semester of thermodynamics, graduate students of thermodynamics and nuclear engineering, and professional nuclear power plant operators. Each group watched a set of transients presented on the displays, using data generated by a high fidelity NPP training simulator, and were then asked three kinds of questions. The first measured their ability to recall the exact values of system state variables. The second measured their ability to recall what qualitative states the system had entered during the transient. The third measured their ability diagnose the nature of the transient. The results of the experiments are reported in relation to the possible use of memory tests to evaluate displays and the interaction of the quality of displays with the level of expertise of operators

ModelMate - A graphical user interface for model analysis

Science.gov (United States)

Banta, Edward R.

2011-01-01

ModelMate is a graphical user interface designed to facilitate use of model-analysis programs with models. This initial version of ModelMate supports one model-analysis program, UCODE_2005, and one model software program, MODFLOW-2005. ModelMate can be used to prepare input files for UCODE_2005, run UCODE_2005, and display analysis results. A link to the GW_Chart graphing program facilitates visual interpretation of results. ModelMate includes capabilities for organizing directories used with the parallel-processing capabilities of UCODE_2005 and for maintaining files in those directories to be identical to a set of files in a master directory. ModelMate can be used on its own or in conjunction with ModelMuse, a graphical user interface for MODFLOW-2005 and PHAST.

Elementary statistics for effective library and information service management

CERN Document Server

Egghe, Leo

2001-01-01

This title describes how best to use statistical data to produce professional reports on library activities. The authors cover data gathering, sampling, graphical representation of data and summary statistics from data, and also include a section on trend analysis. A full bibliography and a subject index make this a key title for any information professional..

Outreach Inside the Library: Attracting and Engaging Millennial Engineering and Science Students

OpenAIRE

Shepherd, Susan

2009-01-01

This poster displays ways in which the Science & Engineering (S&E) Library at UC San Diego has capitalized on the values of Millennials to attract and engage undergraduates in science and engineering with inside-the-library exhibits and events. Appealing to characteristics of Millennials, the S&E Library showcases various types of student work, sponsors engaging and innovative library events, and freely experiments with new ways to draw students into the library.

Production of a Human Antibody Library in the Phage-Display Vector pSEX81.

Science.gov (United States)

Welschof, M; Little, M; Dörsam, H

1998-01-01

Human monoclonal antibodies (MAbs) are more suitable than MAbs of animal origin for clinical applications because of lower hypersensitivity reactions, less formation of circulating immune complexes and lower anti-immunoglobulin responses The classical production of human MAbs via the hybridoma technique or Epstein-Barr virus (EBV) transformation is limited by the instability of cell lines, low antibody production, and the problems of imununizing humans with certain antigens (1,2). A promising alternative 1s the production of human recombinant antibodies (3). Recombinant DNA technology has made it possible to clone human antibody genes in vectors and to generate antibody expression libraries (4-7). One approach has been to amplify and recombine the IgG repertoire of an "immunized" donor. This has been used to isolate several antibodies related to diseases (8,9). In order to obtain more universal antibody libraries the naive IgM repertoire of several "unimmunized" donors were pooled (10,12). The complexity of the combinatorial libraries has been further increased by creating the so-called "semisynthetic" antibody libraries (22-14).

A standard library for modeling satellite orbits on a microcomputer

Science.gov (United States)

Beutel, Kenneth L.

1988-03-01

Introductory students of astrodynamics and the space environment are required to have a fundamental understanding of the kinematic behavior of satellite orbits. This thesis develops a standard library that contains the basic formulas for modeling earth orbiting satellites. This library is used as a basis for implementing a satellite motion simulator that can be used to demonstrate orbital phenomena in the classroom. Surveyed are the equations of orbital elements, coordinate systems and analytic formulas, which are made into a standard method for modeling earth orbiting satellites. The standard library is written in the C programming language and is designed to be highly portable between a variety of computer environments. The simulation draws heavily on the standards established by the library to produce a graphics-based orbit simulation program written for the Apple Macintosh computer. The simulation demonstrates the utility of the standard library functions but, because of its extensive use of the Macintosh user interface, is not portable to other operating systems.

Tumor-targeting peptides from combinatorial libraries*

Science.gov (United States)

Liu, Ruiwu; Li, Xiaocen; Xiao, Wenwu; Lam, Kit S.

2018-01-01

Cancer is one of the major and leading causes of death worldwide. Two of the greatest challenges infighting cancer are early detection and effective treatments with no or minimum side effects. Widespread use of targeted therapies and molecular imaging in clinics requires high affinity, tumor-specific agents as effective targeting vehicles to deliver therapeutics and imaging probes to the primary or metastatic tumor sites. Combinatorial libraries such as phage-display and one-bead one-compound (OBOC) peptide libraries are powerful approaches in discovering tumor-targeting peptides. This review gives an overview of different combinatorial library technologies that have been used for the discovery of tumor-targeting peptides. Examples of tumor-targeting peptides identified from each combinatorial library method will be discussed. Published tumor-targeting peptide ligands and their applications will also be summarized by the combinatorial library methods and their corresponding binding receptors. PMID:27210583

Eukaryotic ribosome display with in situ DNA recovery.

Science.gov (United States)

He, Mingyue; Edwards, Bryan M; Kastelic, Damjana; Taussig, Michael J

2012-01-01

Ribosome display is a cell-free display technology for in vitro selection and optimisation of proteins from large diversified libraries. It operates through the formation of stable protein-ribosome-mRNA (PRM) complexes and selection of ligand-binding proteins, followed by DNA recovery from the selected genetic information. Both prokaryotic and eukaryotic ribosome display systems have been developed. In this chapter, we describe the eukaryotic rabbit reticulocyte method in which a distinct in situ single-primer RT-PCR procedure is used to recover DNA from the selected PRM complexes without the need for prior disruption of the ribosome.

Screening a phage display library for a novel FGF8b-binding peptide with anti-tumor effect on prostate cancer

International Nuclear Information System (INIS)

Wang, Wenhui; Chen, Xilei; Li, Tao; Li, Yanmei; Wang, Ruixue; He, Dan; Luo, Wu; Li, Xiaokun; Wu, Xiaoping

2013-01-01

Fibroblast growth factor 8b (FGF8b) is the major isoform of FGF8 expressed in prostate cancer and it correlates with the stage and grade of the disease. FGF8b has been considered as a potential target for prostate cancer therapy. Here we isolated 12 specific FGF8b-binding phage clones by screening a phage display heptapeptide library with FGF8b. The peptide (HSQAAVP, named as P12) corresponding to one of these clones showed high homology to the immunoglobulin-like (Ig-like) domain II(D2) of high-affinity FGF8b receptor (FGFR3c), contained 3 identical amino acids (AVP) to the authentic FGFR3 D2 sequence aa 163–169 (LLAVPAA) directly participating in ligand binding, carried the same charges as its corresponding motif (aa163–169) in FGFR3c, suggesting that P12 may have a greater potential to interrupt FGF8b binding to its receptors than other identified heptapeptides do. Functional analysis indicated that synthetic P12 peptides mediate significant inhibition of FGF8b-induced cell proliferation, arrest cell cycle at the G0/G1 phase via suppression of Cyclin D1 and PCNA, and blockade of the activations of Erk1/2 and Akt cascades in both prostate cancer cells and vascular endothelial cells. The results demonstrated that the P12 peptide acting as an FGF8b antagonist may have therapeutic potential in prostate cancer. - Highlights: ► A novel FGF8b-binding peptide P12 was isolated from a phage display library. ► The mechanisms for P12 peptide inhibiting cell proliferation were proposed. ► P12 caused cell cycle arrest at G0/G1 phase via suppression of Cyclin D1 and PCNA. ► P12 suppressed FGF8b-induced activations of Akt and MAP kinases. ► P12 acting as an FGF8b antagonist may have therapeutic potential in prostate cancer

Screening a phage display library for a novel FGF8b-binding peptide with anti-tumor effect on prostate cancer

Energy Technology Data Exchange (ETDEWEB)

Wang, Wenhui; Chen, Xilei; Li, Tao; Li, Yanmei; Wang, Ruixue; He, Dan; Luo, Wu [Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632 (China); Li, Xiaokun [Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632 (China); School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou 325035 (China); Wu, Xiaoping, E-mail: twxp@jnu.edu.cn [Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632 (China); School of Pharmaceutical Science, Wenzhou Medical College, Wenzhou 325035 (China)

2013-05-01

Fibroblast growth factor 8b (FGF8b) is the major isoform of FGF8 expressed in prostate cancer and it correlates with the stage and grade of the disease. FGF8b has been considered as a potential target for prostate cancer therapy. Here we isolated 12 specific FGF8b-binding phage clones by screening a phage display heptapeptide library with FGF8b. The peptide (HSQAAVP, named as P12) corresponding to one of these clones showed high homology to the immunoglobulin-like (Ig-like) domain II(D2) of high-affinity FGF8b receptor (FGFR3c), contained 3 identical amino acids (AVP) to the authentic FGFR3 D2 sequence aa 163–169 (LLAVPAA) directly participating in ligand binding, carried the same charges as its corresponding motif (aa163–169) in FGFR3c, suggesting that P12 may have a greater potential to interrupt FGF8b binding to its receptors than other identified heptapeptides do. Functional analysis indicated that synthetic P12 peptides mediate significant inhibition of FGF8b-induced cell proliferation, arrest cell cycle at the G0/G1 phase via suppression of Cyclin D1 and PCNA, and blockade of the activations of Erk1/2 and Akt cascades in both prostate cancer cells and vascular endothelial cells. The results demonstrated that the P12 peptide acting as an FGF8b antagonist may have therapeutic potential in prostate cancer. - Highlights: ► A novel FGF8b-binding peptide P12 was isolated from a phage display library. ► The mechanisms for P12 peptide inhibiting cell proliferation were proposed. ► P12 caused cell cycle arrest at G0/G1 phase via suppression of Cyclin D1 and PCNA. ► P12 suppressed FGF8b-induced activations of Akt and MAP kinases. ► P12 acting as an FGF8b antagonist may have therapeutic potential in prostate cancer.

Heterobimetallic porphyrin complexes displaying triple dynamics: coupled metal motions controlled by constitutional evolution.

Science.gov (United States)

Le Gac, Stéphane; Fusaro, Luca; Roisnel, Thierry; Boitrel, Bernard

2014-05-07

A bis-strap porphyrin ligand (1), with an overhanging carboxylic acid group on each side of the macrocycle, has been investigated toward the formation of dynamic libraries of bimetallic complexes with Hg(II), Cd(II), and Pb(II). Highly heteroselective metalation processes occurred in the presence of Pb(II), with Hg(II) or Cd(II) bound out-of-plane to the N-core and "PbOAc" bound to a carboxylate group of a strap on the opposite side. The resulting complexes, 1(Hg)·PbOAc and 1(Cd)·PbOAc, display three levels of dynamics. The first is strap-level (interactional dynamics), where the PbOAc moiety swings between the left and right side of the strap owing to a second sphere of coordination with lateral amide functions. The second is ligand-level (motional dynamics), where 1(Hg)·PbOAc and 1(Cd)·PbOAc exist as two degenerate states in equilibrium controlled by a chemical effector (AcO(-)). The process corresponds to a double translocation of the metal ions according to an intramolecular migration of Hg(II) or Cd(II) through the N-core, oscillating between the two equivalent overhanging carbonyl groups, coupled to an intermolecular pathway for PbOAc exchanging between the two equivalent overhanging carboxylate groups (N-core(up) ⇆ N-core(down) coupled to strap(down) ⇆ strap(up), i.e., coupled motion #1 in the abstract graphic). The third is library-level (constitutional dynamics), where a dynamic constitutional evolution of the system was achieved by the successive addition of two chemical effectors (DMAP and then AcO(-)). It allowed shifting equilibrium forward and backward between 1(Hg)·PbOAc and the corresponding homobimetallic complexes 1(Hg2)·DMAP and 1(Pb)·PbOAc. The latter displays a different ligand-level dynamics, in the form of an intraligand coupled migration of the Pb(II) ions (N-core(up) ⇆ strap(up) coupled to strap(down) ⇆ N-core(down), i.e., coupled motion #2 in the abstract graphic). In addition, the neutral "bridged" complexes 1HgPb and 1Cd

MOLECULAR DESIGNER: an interactive program for the display of protein structure on the IBM-PC.

Science.gov (United States)

Hannon, G J; Jentoft, J E

1985-09-01

A BASIC interactive graphics program has been developed for the IBM-PC which utilizes the graphics capabilities of that computer to display and manipulate protein structure from coordinates. Structures may be generated from typed files, or from Brookhaven National Laboratories' Protein Data Bank data tapes. Once displayed, images may be rotated, translated and expanded to any desired size. Figures may be viewed as ball-and-stick or space-filling models. Calculated multiple-point perspective may also be added to the display. Docking manipulations are possible since more than a single figure may be displayed and manipulated simultaneously. Further, stereo images and red/blue three-dimensional images may be generated using the accompanying DESIPLOT program and an HP-7475A plotter. A version of the program is also currently available for the Apple Macintosh. Full implementation on the Macintosh requires 512 K and at least one disk drive. Otherwise this version is essentially identical to the IBM-PC version described herein.

Positive Correlation Between Academic Library Services and High-Impact Practices for

Directory of Open Access Journals (Sweden)

Saori Wendy Herman, MLIS, AHIP

2016-03-01

Full Text Available Objective – To investigate the perceived alignment between academic library services and high-impact practices (HIPs that affect student retention. Design – Survey questionnaire. Setting – Public comprehensive universities in the United States of America with a Carnegie classification of master’s level as of January 2013. Subjects – 68 library deans or directors out of the 271 who were originally contacted. Methods – The author used Qualtrics software to create a survey based on the HIPs, tested the survey for reliability, and then distributed it to 271 universities. Library services were grouped into 1 of 3 library scales: library collection, library instruction, or library facilities. The survey consisted of a matrix of 10 Likert-style questions addressing the perceived level of alignment between the library scales and the HIPs. Each question provided an opportunity for the respondent to enter a “brief description of support practices” (p 477. Additional demographic questions addressed the years of experience of the respondent, undergraduate student enrollment of the university, and whether librarians held faculty rank. Main Results – The author measured Pearson correlation coefficients and found a positive correlation between the library scales and the HIPs. All three library scales displayed a moderately strong positive correlation between first-year seminars and experiences (HIP 1, common intellectual experiences (HIP 2, writing-intensive courses (HIP 4, undergraduate research (HIP 6, diversity and global learning (HIP 7, service learning and community-based learning (HIP 8, internships (HIP 9, and capstone courses and projects (HIP 10. The library collections scale and library facilities scale displayed a moderately strong correlation with learning communities (HIP 3 and collaborative assignments and projects (HIP 5. The library instruction scale displayed a strong positive correlation with HIP 3 and a very strong

Digital Image Processing Overview For Helmet Mounted Displays

Science.gov (United States)

Parise, Michael J.

1989-09-01

Digital image processing provides a means to manipulate an image and presents a user with a variety of display formats that are not available in the analog image processing environment. When performed in real time and presented on a Helmet Mounted Display, system capability and flexibility are greatly enhanced. The information content of a display can be increased by the addition of real time insets and static windows from secondary sensor sources, near real time 3-D imaging from a single sensor can be achieved, graphical information can be added, and enhancement techniques can be employed. Such increased functionality is generating a considerable amount of interest in the military and commercial markets. This paper discusses some of these image processing techniques and their applications.

Interactive simulation of nuclear power systems using a dedicated minicomputer - computer graphics facility

International Nuclear Information System (INIS)

Tye, C.; Sezgen, A.O.

1980-01-01

The design of control systems and operational procedures for large scale nuclear power plant poses a difficult optimization problem requiring a lot of computational effort. Plant dynamic simulation using digital minicomputers offers the prospect of relatively low cost computing and when combined with graphical input/output provides a powerful tool for studying such problems. The paper discusses the results obtained from a simulation study carried out at the Computer Graphics Unit of the University of Manchester using a typical station control model for an Advanced Gas Cooled reactor. Particular reference is placed on the use of computer graphics for information display, parameter and control system optimization and techniques for using graphical input for defining and/or modifying the control system topology. Experience gained from this study has shown that a relatively modest minicomputer system can be used for simulating large scale dynamic systems and that highly interactive computer graphics can be used to advantage to relieve the designer of many of the tedious aspects of simulation leaving him free to concentrate on the more creative aspects of his work. (author)

High performance graphics processors for medical imaging applications

International Nuclear Information System (INIS)

Goldwasser, S.M.; Reynolds, R.A.; Talton, D.A.; Walsh, E.S.

1989-01-01

This paper describes a family of high- performance graphics processors with special hardware for interactive visualization of 3D human anatomy. The basic architecture expands to multiple parallel processors, each processor using pipelined arithmetic and logical units for high-speed rendering of Computed Tomography (CT), Magnetic Resonance (MR) and Positron Emission Tomography (PET) data. User-selectable display alternatives include multiple 2D axial slices, reformatted images in sagittal or coronal planes and shaded 3D views. Special facilities support applications requiring color-coded display of multiple datasets (such as radiation therapy planning), or dynamic replay of time- varying volumetric data (such as cine-CT or gated MR studies of the beating heart). The current implementation is a single processor system which generates reformatted images in true real time (30 frames per second), and shaded 3D views in a few seconds per frame. It accepts full scale medical datasets in their native formats, so that minimal preprocessing delay exists between data acquisition and display

Scalable Adaptive Graphics Environment (SAGE) Software for the Visualization of Large Data Sets on a Video Wall

Science.gov (United States)

Jedlovec, Gary; Srikishen, Jayanthi; Edwards, Rita; Cross, David; Welch, Jon; Smith, Matt

2013-01-01

The use of collaborative scientific visualization systems for the analysis, visualization, and sharing of "big data" available from new high resolution remote sensing satellite sensors or four-dimensional numerical model simulations is propelling the wider adoption of ultra-resolution tiled display walls interconnected by high speed networks. These systems require a globally connected and well-integrated operating environment that provides persistent visualization and collaboration services. This abstract and subsequent presentation describes a new collaborative visualization system installed for NASA's Shortterm Prediction Research and Transition (SPoRT) program at Marshall Space Flight Center and its use for Earth science applications. The system consists of a 3 x 4 array of 1920 x 1080 pixel thin bezel video monitors mounted on a wall in a scientific collaboration lab. The monitors are physically and virtually integrated into a 14' x 7' for video display. The display of scientific data on the video wall is controlled by a single Alienware Aurora PC with a 2nd Generation Intel Core 4.1 GHz processor, 32 GB memory, and an AMD Fire Pro W600 video card with 6 mini display port connections. Six mini display-to-dual DVI cables are used to connect the 12 individual video monitors. The open source Scalable Adaptive Graphics Environment (SAGE) windowing and media control framework, running on top of the Ubuntu 12 Linux operating system, allows several users to simultaneously control the display and storage of high resolution still and moving graphics in a variety of formats, on tiled display walls of any size. The Ubuntu operating system supports the open source Scalable Adaptive Graphics Environment (SAGE) software which provides a common environment, or framework, enabling its users to access, display and share a variety of data-intensive information. This information can be digital-cinema animations, high-resolution images, high-definition video

Scalable Adaptive Graphics Environment (SAGE) Software for the Visualization of Large Data Sets on a Video Wall

Science.gov (United States)

Jedlovec, G.; Srikishen, J.; Edwards, R.; Cross, D.; Welch, J. D.; Smith, M. R.

2013-12-01

The use of collaborative scientific visualization systems for the analysis, visualization, and sharing of 'big data' available from new high resolution remote sensing satellite sensors or four-dimensional numerical model simulations is propelling the wider adoption of ultra-resolution tiled display walls interconnected by high speed networks. These systems require a globally connected and well-integrated operating environment that provides persistent visualization and collaboration services. This abstract and subsequent presentation describes a new collaborative visualization system installed for NASA's Short-term Prediction Research and Transition (SPoRT) program at Marshall Space Flight Center and its use for Earth science applications. The system consists of a 3 x 4 array of 1920 x 1080 pixel thin bezel video monitors mounted on a wall in a scientific collaboration lab. The monitors are physically and virtually integrated into a 14' x 7' for video display. The display of scientific data on the video wall is controlled by a single Alienware Aurora PC with a 2nd Generation Intel Core 4.1 GHz processor, 32 GB memory, and an AMD Fire Pro W600 video card with 6 mini display port connections. Six mini display-to-dual DVI cables are used to connect the 12 individual video monitors. The open source Scalable Adaptive Graphics Environment (SAGE) windowing and media control framework, running on top of the Ubuntu 12 Linux operating system, allows several users to simultaneously control the display and storage of high resolution still and moving graphics in a variety of formats, on tiled display walls of any size. The Ubuntu operating system supports the open source Scalable Adaptive Graphics Environment (SAGE) software which provides a common environment, or framework, enabling its users to access, display and share a variety of data-intensive information. This information can be digital-cinema animations, high-resolution images, high-definition video

Consed: a graphical editor for next-generation sequencing

OpenAIRE

Gordon, David; Green, Phil

2013-01-01

Summary: The rapid growth of DNA sequencing throughput in recent years implies that graphical interfaces for viewing and correcting errors must now handle large numbers of reads, efficiently pinpoint regions of interest and automate as many tasks as possible. We have adapted consed to reflect this. To allow full-feature editing of large datasets while keeping memory requirements low, we developed a viewer, bamScape, that reads billion-read BAM files, identifies and displays problem areas for ...

WinGraphics: An optimized windowing environment for interactive real-time simulations

International Nuclear Information System (INIS)

Verboncoeur, J.P.; Vahedi, V.

1989-01-01

We have developed a customized windowing environment, Win Graphics, which provides particle simulation codes with an interactive user interface. The environment supports real-time animation of the simulation, displaying multiple diagnostics as they evolve in time. In addition, keyboard and printer (PostScript and dot matrix) support is provided. This paper describes this environment

DELIN and DELOG codes for graphic representation of gamma ray spectra

International Nuclear Information System (INIS)

Romero, L.; Travesi, A.

1983-01-01

Two Fortran IV Codes has been developed for graphic representation of the gamma-ray spectra obtained with Ge Li detectors and multichannel analyzers. The grafic plotting es carried out with the H.P. Graphic Plotter Mod HP-7221 A, using the graphic package software GRAPHICS-1000 from Hewlett-Packard. The codes have a great versatility and the representation of gamma spectra can ba done in a lineal, semi log, or log-log scale, as desired. The gamma ray spectra data are feed into the computer through magnetic tape or perfored paper tape. The different out-put options and complementary data are given in a conversational way through a terminal with T.V. displays. Among the options that can be selected by the user are the following: - smoothing the spectra - drawing the spectra point by point or continuous - out-put drawing an 1, 2, or 4 sheet with automatic division of the energy scale. - overlapping of selected spectra regions in Y scale ampliation with automatic print-out of the region limits and ampliation factor. - Printing spectra data and identifications of selected photo peaks. The codes can be employed with any computer using printing devices, HP-Graphics 1000 software compatible, but are easily modified for another printing software since their modular structure with Fortran IV written

Applications of computer-graphics animation for motion-perception research

Science.gov (United States)

Proffitt, D. R.; Kaiser, M. K.

1986-01-01

The advantages and limitations of using computer animated stimuli in studying motion perception are presented and discussed. Most current programs of motion perception research could not be pursued without the use of computer graphics animation. Computer generated displays afford latitudes of freedom and control that are almost impossible to attain through conventional methods. There are, however, limitations to this presentational medium. At present, computer generated displays present simplified approximations of the dynamics in natural events. Very little is known about how the differences between natural events and computer simulations influence perceptual processing. In practice, the differences are assumed to be irrelevant to the questions under study, and that findings with computer generated stimuli will generalize to natural events.

Three-dimensional demonstration of liver and spleen by computer graphics technique

International Nuclear Information System (INIS)

Kashiwagi, Toru; Azuma, Masayoshi; Katayama, Kazuhiro; Yoshioka, Hiroaki; Ishizu, Hiromi; Mitsutani, Natsuki; Koizumi, Takao; Takayama, Ichiro

1987-01-01

Three-dimensional demonstration system of the liver and spleen has been developed using computer graphics technique. Three-dimensional models were constructed from CT images of the organ surface. The three-dimensional images were displayed as wire-frame and/or solid models on the color CRT. The anatomical surface of the liver and spleen was realistically viewed from any direction. In liver cirrhosis, atrophy of the right lobe, hypertrophy of the left lobe and splenomegaly were displayed vividly. The liver and hepatoma were displayed as wire-frame and solid models respectively on the same image. This combined display clarified the intrahepatic location of hepatoma together with configuration of liver and hepatoma. Furthermore, superimposed display of three dimensional models and celiac angiogram enabled us to understand the location and configuration of lesions more easily than the original CT data or angiogram alone. Therefore, it is expected that this system is clinically useful for noninvasive evaluation of patho-morphological changes of the liver and spleen. (author)

37 CFR 201.14 - Warnings of copyright for use by certain libraries and archives.

Science.gov (United States)

2010-07-01

... by certain libraries and archives. 201.14 Section 201.14 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES GENERAL PROVISIONS § 201.14 Warnings of copyright for use by certain libraries and archives. (a) Definitions. (1) A Display Warning of...

MPGT - THE MISSION PLANNING GRAPHICAL TOOL

Science.gov (United States)

Jeletic, J. F.

1994-01-01

The Mission Planning Graphical Tool (MPGT) provides mission analysts with a mouse driven graphical representation of the spacecraft and environment data used in spaceflight planning. Developed by the Flight Dynamics Division at NASA's Goddard Space Flight Center, MPGT is designed to be a generic tool that can be configured to analyze any specified earth orbiting spacecraft mission. The data is presented as a series of overlays on top of a 2-dimensional or 3-dimensional projection of the earth. Up to six spacecraft orbit tracks can be drawn at one time. Position data can be obtained by either an analytical process or by use of ephemeris files. If the user chooses to propagate the spacecraft orbit using an ephemeris file, then Goddard Trajectory Determination System (GTDS) formatted ephemeris files must be supplied. The MPGT User's Guide provides a complete description of the GTDS ephemeris file format so that users can create their own. Other overlays included are ground station antenna masks, solar and lunar ephemeris, Tracking Data and Relay Satellite System (TDRSS) coverage, a field-of-view swath, and orbit number. From these graphical representations an analyst can determine such spacecraft-related constraints as communication coverage, interference zone infringement, sunlight availability, and instrument target visibility. The presentation of time and geometric data as graphical overlays on a world map makes possible quick analyses of trends and time-oriented parameters. For instance, MPGT can display the propagation of the position of the Sun and Moon over time, shadowing of sunrise/sunset terminators to indicate spacecraft and Earth day/night, and color coding of the spacecraft orbit tracks to indicate spacecraft day/night. With the 3-dimensional display, the user specifies a vector that represents the position in the universe from which the user wishes to view the earth. From these "viewpoint" parameters the user can zoom in on or rotate around the earth

Graphical user interface concepts for tactical augmented reality

Science.gov (United States)

Argenta, Chris; Murphy, Anne; Hinton, Jeremy; Cook, James; Sherrill, Todd; Snarski, Steve

2010-04-01

Applied Research Associates and BAE Systems are working together to develop a wearable augmented reality system under the DARPA ULTRA-Vis program†. Our approach to achieve the objectives of ULTRAVis, called iLeader, incorporates a full color 40° field of view (FOV) see-thru holographic waveguide integrated with sensors for full position and head tracking to provide an unobtrusive information system for operational maneuvers. iLeader will enable warfighters to mark-up the 3D battle-space with symbologic identification of graphical control measures, friendly force positions and enemy/target locations. Our augmented reality display provides dynamic real-time painting of symbols on real objects, a pose-sensitive 360° representation of relevant object positions, and visual feedback for a variety of system activities. The iLeader user interface and situational awareness graphical representations are highly intuitive, nondisruptive, and always tactically relevant. We used best human-factors practices, system engineering expertise, and cognitive task analysis to design effective strategies for presenting real-time situational awareness to the military user without distorting their natural senses and perception. We present requirements identified for presenting information within a see-through display in combat environments, challenges in designing suitable visualization capabilities, and solutions that enable us to bring real-time iconic command and control to the tactical user community.

An SML Driven Graphical User Interface and Application Management Toolkit

International Nuclear Information System (INIS)

White, Greg R

2002-01-01

In the past, the features of a user interface were limited by those available in the existing graphical widgets it used. Now, improvements in processor speed have fostered the emergence of interpreted languages, in which the appropriate method to render a given data object can be loaded at runtime. XML can be used to precisely describe the association of data types with their graphical handling (beans), and Java provides an especially rich environment for programming the graphics. We present a graphical user interface builder based on Java Beans and XML, in which the graphical screens are described textually (in files or a database) in terms of their screen components. Each component may be a simple text read back, or a complex plot. The programming model provides for dynamic data pertaining to a component to be forwarded synchronously or asynchronously, to the appropriate handler, which may be a built-in method, or a complex applet. This work was initially motivated by the need to move the legacy VMS display interface of the SLAC Control Program to another platform while preserving all of its existing functionality. However the model allows us a powerful and generic system for adding new kinds of graphics, such as Matlab, data sources, such as EPICS, middleware, such as AIDA[1], and transport, such as XML and SOAP. The system will also include a management console, which will be able to report on the present usage of the system, for instance who is running it where and connected to which channels

Real-time Image Generation for Compressive Light Field Displays

International Nuclear Information System (INIS)

Wetzstein, G; Lanman, D; Hirsch, M; Raskar, R

2013-01-01

With the invention of integral imaging and parallax barriers in the beginning of the 20th century, glasses-free 3D displays have become feasible. Only today—more than a century later—glasses-free 3D displays are finally emerging in the consumer market. The technologies being employed in current-generation devices, however, are fundamentally the same as what was invented 100 years ago. With rapid advances in optical fabrication, digital processing power, and computational perception, a new generation of display technology is emerging: compressive displays exploring the co-design of optical elements and computational processing while taking particular characteristics of the human visual system into account. In this paper, we discuss real-time implementation strategies for emerging compressive light field displays. We consider displays composed of multiple stacked layers of light-attenuating or polarization-rotating layers, such as LCDs. The involved image generation requires iterative tomographic image synthesis. We demonstrate that, for the case of light field display, computed tomographic light field synthesis maps well to operations included in the standard graphics pipeline, facilitating efficient GPU-based implementations with real-time framerates.

IDAS, software support for mathematical models and map-based graphics

International Nuclear Information System (INIS)

Birnbaum, M.D.; Wecker, D.B.

1984-01-01

IDAS (Intermediate Dose Assessment System) was developed for the U.S. Nuclear Regulatory Commission as a hardware/software host for radiological models and display of map-based plume graphics at the Operations Center (HQ), regional incident response centers, and site emergency facilities. IDAS design goals acknowledged the likelihood of future changes in the suite of models and the composition of map features for analysis and graphical display. IDAS provides a generalized software support environment to programmers and users of modeling programs. A database manager process provides multi-user access control to all input and output data for modeling programs. A programmer-created data description file (schema) specifies data field names, data types, legal and recommended ranges, default values, preferred units of measurement, and ''help'' text. Subroutine calls to IDAS from a model program invoke a consistent user interface which can show any of the schema contents, convert units of measurement, and route data to multiple logical devices, including the database. A stand-alone data editor allows the user to read and write model data records without execution of a model. IDAS stores digitized map features in a 4-level naming hierarchy. A user can select the map icon, color, and whether to show a stored name tag, for each map feature. The user also selects image scale (zoom) within limits set by map digitization. The resulting image combines static map information, computed analytic modeling results, and the user's feature selections for display to decision-makers

ModFossa: A library for modeling ion channels using Python.

Science.gov (United States)

Ferneyhough, Gareth B; Thibealut, Corey M; Dascalu, Sergiu M; Harris, Frederick C

2016-06-01

The creation and simulation of ion channel models using continuous-time Markov processes is a powerful and well-used tool in the field of electrophysiology and ion channel research. While several software packages exist for the purpose of ion channel modeling, most are GUI based, and none are available as a Python library. In an attempt to provide an easy-to-use, yet powerful Markov model-based ion channel simulator, we have developed ModFossa, a Python library supporting easy model creation and stimulus definition, complete with a fast numerical solver, and attractive vector graphics plotting.

Particle swarm optimization for automatic creation of complex graphic characters

International Nuclear Information System (INIS)

Fister, Iztok; Perc, Matjaž; Ljubič, Karin; Kamal, Salahuddin M.; Iglesias, Andres; Fister, Iztok

2015-01-01

Nature-inspired algorithms are a very promising tool for solving the hardest problems in computer sciences and mathematics. These algorithms are typically inspired by the fascinating behavior at display in biological systems, such as bee swarms or fish schools. So far, these algorithms have been applied in many practical applications. In this paper, we present a simple particle swarm optimization, which allows automatic creation of complex two-dimensional graphic characters. The method involves constructing the base characters, optimizing the modifications of the base characters with the particle swarm optimization algorithm, and finally generating the graphic characters from the solution. We demonstrate the effectiveness of our approach with the creation of simple snowman, but we also outline in detail how more complex characters can be created

Interactive graphics analysis system for nuclear engineering applications

International Nuclear Information System (INIS)

Danchak, M.; Moyer, W.R.; Becker, M.

1973-01-01

From working with continuous slowing down theory, the need was recognized for a system which allowed rapid calculation of the theoretical flux, instant comparison with experiment and a simple means of iterating on the slowing down parameters to force flux agreement and reflect cross section modification. Similar requirements exist in other areas of nuclear work for streamlining and simplifying the data analysis process. As a solution, a unique interactive graphics analysis system (RIGAS) was devised to allow a user to calculate, display, compare, manipulate and modify his data without requiring any programming on his part. This was accomplished by establishing human primacy, through extensive human factor considerations, and designing a man-machine dialogue which responds to the mere push of a button. This system results in an instrument which maximizes man's decision making capability and the computer's speed to improve graphic communication and data analysis. (14 figs) (U.S.)

Telemetry Monitoring and Display Using LabVIEW

Science.gov (United States)

Wells, George; Baroth, Edmund C.

1993-01-01

The Measurement Technology Center of the Instrumentation Section configures automated data acquisition systems to meet the diverse needs of JPL's experimental research community. These systems are based on personal computers or workstations (Apple, IBM/Compatible, Hewlett-Packard, and Sun Microsystems) and often include integrated data analysis, visualization and experiment control functions in addition to data acquisition capabilities. These integrated systems may include sensors, signal conditioning, data acquisition interface cards, software, and a user interface. Graphical programming is used to simplify configuration of such systems. Employment of a graphical programming language is the most important factor in enabling the implementation of data acquisition, analysis, display and visualization systems at low cost. Other important factors are the use of commercial software packages and off-the-shelf data acquisition hardware where possible. Understanding the experimenter's needs is also critical. An interactive approach to user interface construction and training of operators is also important. One application was created as a result of a competative effort between a graphical programming language team and a text-based C language programming team to verify the advantages of using a graphical programming language approach. With approximately eight weeks of funding over a period of three months, the text-based programming team accomplished about 10% of the basic requirements, while the Macintosh/LabVIEW team accomplished about 150%, having gone beyond the original requirements to simulate a telemetry stream and provide utility programs. This application verified that using graphical programming can significantly reduce software development time. As a result of this initial effort, additional follow-on work was awarded to the graphical programming team.

GCL – An Easy Way for Creating Graphical User Interfaces

Directory of Open Access Journals (Sweden)

Mariusz Trzaska

2011-02-01

Full Text Available Graphical User Interfaces (GUI can be created using several approaches. Beside using visual editors or a manually written source code, it is possible to employ a declarative method. Such a solution usually allows working on a higher abstraction level which saves the developers' time and reduces errors. The approach can follow many ideas. One of them is based on utilizing a Domain Specific Language (DSL. In this paper we present the results of our research concerning a DSL language called GCL (GUI Creating Language. The prototype is implemented as a library for Java with an API emulating the syntax and semantics of a DSL language. A programmer, using a few keywords, is able to create different types of GUIs, including forms, panels, dialogs, etc. The widgets of the GUI are built automatically during the run-time phase based on a given data instance (an ordinary Java object and optionally are to be customized by the programmer. The main contribution of our work is delivering a working library for a popular platform. The library could be easily ported for other programming languages such the MS C#.

Graphics gems II

CERN Document Server

Arvo, James

1991-01-01

Graphics Gems II is a collection of articles shared by a diverse group of people that reflect ideas and approaches in graphics programming which can benefit other computer graphics programmers.This volume presents techniques for doing well-known graphics operations faster or easier. The book contains chapters devoted to topics on two-dimensional and three-dimensional geometry and algorithms, image processing, frame buffer techniques, and ray tracing techniques. The radiosity approach, matrix techniques, and numerical and programming techniques are likewise discussed.Graphics artists and comput

Dissemination of 3D Visualizations of Complex Function Data for the NIST Digital Library of Mathematical Functions

Directory of Open Access Journals (Sweden)

Qiming Wang

2007-03-01

Full Text Available The National Institute of Standards and Technology (NIST is developing a digital library to replace the widely used National Bureau of Standards Handbook of Mathematical Functions published in 1964. The NIST Digital Library of Mathematical Functions (DLMF will include formulas, methods of computation, references, and links to software for over forty functions. It will be published both in hardcopy format and as a website featuring interactive navigation, a mathematical equation search, 2D graphics, and dynamic interactive 3D visualizations. This paper focuses on the development and accessibility of the 3D visualizations for the digital library. We examine the techniques needed to produce accurate computations of function data, and through a careful evaluation of several prototypes, we address the advantages and disadvantages of using various technologies, including the Virtual Reality Modeling Language (VRML, interactive embedded graphics, and video capture to render and disseminate the visualizations in an environment accessible to users on various platforms.

Design Graphics

Science.gov (United States)

1990-01-01

A mathematician, David R. Hedgley, Jr. developed a computer program that considers whether a line in a graphic model of a three-dimensional object should or should not be visible. Known as the Hidden Line Computer Code, the program automatically removes superfluous lines and displays an object from a specific viewpoint, just as the human eye would see it. An example of how one company uses the program is the experience of Birdair which specializes in production of fabric skylights and stadium covers. The fabric called SHEERFILL is a Teflon coated fiberglass material developed in cooperation with DuPont Company. SHEERFILL glazed structures are either tension structures or air-supported tension structures. Both are formed by patterned fabric sheets supported by a steel or aluminum frame or cable network. Birdair uses the Hidden Line Computer Code, to illustrate a prospective structure to an architect or owner. The program generates a three- dimensional perspective with the hidden lines removed. This program is still used by Birdair and continues to be commercially available to the public.

Topographic Digital Raster Graphics - USGS DIGITAL RASTER GRAPHICS

Data.gov (United States)

NSGIC Local Govt | GIS Inventory — USGS Topographic Digital Raster Graphics downloaded from LABINS (http://data.labins.org/2003/MappingData/drg/drg_stpl83.cfm). A digital raster graphic (DRG) is a...

Measuring Cognitive Load in Test Items: Static Graphics versus Animated Graphics

Science.gov (United States)

Dindar, M.; Kabakçi Yurdakul, I.; Inan Dönmez, F.

2015-01-01

The majority of multimedia learning studies focus on the use of graphics in learning process but very few of them examine the role of graphics in testing students' knowledge. This study investigates the use of static graphics versus animated graphics in a computer-based English achievement test from a cognitive load theory perspective. Three…

Application of computer graphics in the design of custom orthopedic implants.

Science.gov (United States)

Bechtold, J E

1986-10-01

Implementation of newly developed computer modelling techniques and computer graphics displays and software have greatly aided the orthopedic design engineer and physician in creating a custom implant with good anatomic conformity in a short turnaround time. Further advances in computerized design and manufacturing will continue to simplify the development of custom prostheses and enlarge their niche in the joint replacement market.

Industrial Personal Computer based Display for Nuclear Safety System

International Nuclear Information System (INIS)

Kim, Ji Hyeon; Kim, Aram; Jo, Jung Hee; Kim, Ki Beom; Cheon, Sung Hyun; Cho, Joo Hyun; Sohn, Se Do; Baek, Seung Min

2014-01-01

The safety display of nuclear system has been classified as important to safety (SIL:Safety Integrity Level 3). These days the regulatory agencies are imposing more strict safety requirements for digital safety display system. To satisfy these requirements, it is necessary to develop a safety-critical (SIL 4) grade safety display system. This paper proposes industrial personal computer based safety display system with safety grade operating system and safety grade display methods. The description consists of three parts, the background, the safety requirements and the proposed safety display system design. The hardware platform is designed using commercially available off-the-shelf processor board with back plane bus. The operating system is customized for nuclear safety display application. The display unit is designed adopting two improvement features, i.e., one is to provide two separate processors for main computer and display device using serial communication, and the other is to use Digital Visual Interface between main computer and display device. In this case the main computer uses minimized graphic functions for safety display. The display design is at the conceptual phase, and there are several open areas to be concreted for a solid system. The main purpose of this paper is to describe and suggest a methodology to develop a safety-critical display system and the descriptions are focused on the safety requirement point of view

Industrial Personal Computer based Display for Nuclear Safety System

Energy Technology Data Exchange (ETDEWEB)

Kim, Ji Hyeon; Kim, Aram; Jo, Jung Hee; Kim, Ki Beom; Cheon, Sung Hyun; Cho, Joo Hyun; Sohn, Se Do; Baek, Seung Min [KEPCO, Youngin (Korea, Republic of)

2014-08-15

The safety display of nuclear system has been classified as important to safety (SIL:Safety Integrity Level 3). These days the regulatory agencies are imposing more strict safety requirements for digital safety display system. To satisfy these requirements, it is necessary to develop a safety-critical (SIL 4) grade safety display system. This paper proposes industrial personal computer based safety display system with safety grade operating system and safety grade display methods. The description consists of three parts, the background, the safety requirements and the proposed safety display system design. The hardware platform is designed using commercially available off-the-shelf processor board with back plane bus. The operating system is customized for nuclear safety display application. The display unit is designed adopting two improvement features, i.e., one is to provide two separate processors for main computer and display device using serial communication, and the other is to use Digital Visual Interface between main computer and display device. In this case the main computer uses minimized graphic functions for safety display. The display design is at the conceptual phase, and there are several open areas to be concreted for a solid system. The main purpose of this paper is to describe and suggest a methodology to develop a safety-critical display system and the descriptions are focused on the safety requirement point of view.

The design of a graphics processor

International Nuclear Information System (INIS)

Holmes, M.; Thorne, A.R.

1975-12-01

The design of a graphics processor is described which takes into account known and anticipated user requirements, the availability of cheap minicomputers, the state of integrated circuit technology, and the overall need to minimise cost for a given performance. The main user needs are the ability to display large high resolution pictures, and to dynamically change the user's view in real time by means of fast coordinate processing hardware. The transformations that can be applied to 2D or 3D coordinates either singly or in combination are: translation, scaling, mirror imaging, rotation, and the ability to map the transformation origin on to any point on the screen. (author)

Computer system for nuclear power plant parameter display

International Nuclear Information System (INIS)

Stritar, A.; Klobuchar, M.

1990-01-01

The computer system for efficient, cheap and simple presentation of data on the screen of the personal computer is described. The display is in alphanumerical or graphical form. The system can be used for the man-machine interface in the process monitoring system of the nuclear power plant. It represents the third level of the new process computer system of the Nuclear Power Plant Krsko. (author)

Graphics in DAQSIM

International Nuclear Information System (INIS)

Wang, C.C.; Booth, A.W.; Chen, Y.M.; Botlo, M.

1993-06-01

At the Superconducting Super Collider Laboratory (SSCL) a tool called DAQSIM has been developed to study the behavior of Data Acquisition (DAQ) systems. This paper reports and discusses the graphics used in DAQSIM. DAQSIM graphics includes graphical user interface (GUI), animation, debugging, and control facilities. DAQSIM graphics not only provides a convenient DAQ simulation environment, it also serves as an efficient manager in simulation development and verification

A DDC Bibliography on Optical or Graphic Information Processing (Information Sciences Series). Volume I.

Science.gov (United States)

Defense Documentation Center, Alexandria, VA.

This unclassified-unlimited bibliography contains 183 references, with abstracts, dealing specifically with optical or graphic information processing. Citations are grouped under three headings: display devices and theory, character recognition, and pattern recognition. Within each group, they are arranged in accession number (AD-number) sequence.…

The Real Time Interactive Display Environment (RTIDE), a display building tool developed by Space Shuttle flight controllers

Science.gov (United States)

Kalvelage, Thomas A.

1989-01-01

NASA's Mission Control Center, located at Johnson Space Center, is incrementally moving from a centralized architecture to a distributed architecture. Starting with STS-29, some host-driven console screens will be replaced with graphics terminals driven by workstations. These workstations will be supplied realtime data first by the Real Time Data System (RTDS), a system developed inhouse, and then months later (in parallel with RTDS) by interim and subsequently operational versions of the Mission Control Center Upgrade (MCCU) software package. The Real Time Interactive Display Environment (RTIDE) was built by Space Shuttle flight controllers to support the rapid development of multiple new displays to support Shuttle flights. RTIDE is a display building tool that allows non-programmers to define object-oriented, event-driven, mouseable displays. Particular emphasis was placed on upward compatibility between RTIDE versions, ability to acquire data from different data sources, realtime performance, ability to modularly upgrade RTIDE, machine portability, and a clean, powerful user interface. The operational and organizational factors that drove RTIDE to its present form, the actual design itself, simulation and flight performance, and lessons learned in the process are discussed.

Advanced display object selection methods for enhancing user-computer productivity

Science.gov (United States)

Osga, Glenn A.

1993-01-01

The User-Interface Technology Branch at NCCOSC RDT&E Division has been conducting a series of studies to address the suitability of commercial off-the-shelf (COTS) graphic user-interface (GUI) methods for efficiency and performance in critical naval combat systems. This paper presents an advanced selection algorithm and method developed to increase user performance when making selections on tactical displays. The method has also been applied with considerable success to a variety of cursor and pointing tasks. Typical GUI's allow user selection by: (1) moving a cursor with a pointing device such as a mouse, trackball, joystick, touchscreen; and (2) placing the cursor on the object. Examples of GUI objects are the buttons, icons, folders, scroll bars, etc. used in many personal computer and workstation applications. This paper presents an improved method of selection and the theoretical basis for the significant performance gains achieved with various input devices tested. The method is applicable to all GUI styles and display sizes, and is particularly useful for selections on small screens such as notebook computers. Considering the amount of work-hours spent pointing and clicking across all styles of available graphic user-interfaces, the cost/benefit in applying this method to graphic user-interfaces is substantial, with the potential for increasing productivity across thousands of users and applications.

Creating Library Interiors: Planning and Design Considerations.

Science.gov (United States)

Jones, Plummer Alston, Jr.; Barton, Phillip K.

1997-01-01

Examines design considerations for public library interiors: access; acoustical treatment; assignable and nonassignable space; building interiors: ceilings, clocks, color, control, drinking fountains; exhibit space: slotwall display, floor coverings, floor loading, furniture, lighting, mechanical systems, public address, copying machines,…

DEBUGGER: Developing a graphical user interface to debug FPGAs

CERN Document Server

AUTHOR|(SzGeCERN)773309

2015-01-01

As part of the summer student projects, an FPGA debugger was designed using Qt- framework. The aim of this project is to help Data Acquisition System (DAQ) experts of COMPASS experiment to easily monitor the state of each FPGA being used. It is needful to continually monitor their state. A Graphical User Interface (GUI) has then been designed to aid experts to do so. Via IP-Bus, the content of the FPGA under investigation is displayed to the user.

Organization of graphic controls for a state of the art human interface

International Nuclear Information System (INIS)

Speckert, G.C.

1980-01-01

This paper describes a proposed control system organization, based on an existing design for the Lawrence Livermore National Laboratory's Mirror Fusion Test Facility (MFTF). The trend of improving traditional status (output) devices such as lamps, gauges, and other single function status displays by use of computer generated color video displays in modern supervisory control environments has been extended to include control (input) devices. For MFTF, the usual arrays of knobs, switches, and physical buttons have been almost entirely replaced by graphic images of buttons which are displayed on color monitors equipped with curved transparent touchsensors. The light touch of a finger brings the operator the desired set of controls, requests a particular status display, or issues a command to the system being controlled, while banks of status monitors dynamically display his changing world. Because the operator can only interact with a portion of the total controls at any one time, the organization of these controls is critical for optimization of the man-machine interface

Distributed interactive graphics applications in computational fluid dynamics

International Nuclear Information System (INIS)

Rogers, S.E.; Buning, P.G.; Merritt, F.J.

1987-01-01

Implementation of two distributed graphics programs used in computational fluid dynamics is discussed. Both programs are interactive in nature. They run on a CRAY-2 supercomputer and use a Silicon Graphics Iris workstation as the front-end machine. The hardware and supporting software are from the Numerical Aerodynamic Simulation project. The supercomputer does all numerically intensive work and the workstation, as the front-end machine, allows the user to perform real-time interactive transformations on the displayed data. The first program was written as a distributed program that computes particle traces for fluid flow solutions existing on the supercomputer. The second is an older post-processing and plotting program modified to run in a distributed mode. Both programs have realized a large increase in speed over that obtained using a single machine. By using these programs, one can learn quickly about complex features of a three-dimensional flow field. Some color results are presented

Eye Gaze Controlled Projected Display in Automotive and Military Aviation Environments

Directory of Open Access Journals (Sweden)

Gowdham Prabhakar

2018-01-01

Full Text Available This paper presents an eye gaze controlled projected display that can be used in aviation and automotive environment as a head up display. We have presented details of the hardware and software used in developing the display and an algorithm to improve performance of point and selection tasks in eye gaze controlled graphical user interface. The algorithm does not require changing layout of an interface; it rather puts a set of hotspots on clickable targets using a Simulated Annealing algorithm. Four user studies involving driving and flight simulators have found that the proposed projected display can improve driving and flying performance and significantly reduce pointing and selection times for secondary mission control tasks compared to existing interaction systems.

JDiffraction: A GPGPU-accelerated JAVA library for numerical propagation of scalar wave fields

Science.gov (United States)

Piedrahita-Quintero, Pablo; Trujillo, Carlos; Garcia-Sucerquia, Jorge

2017-05-01

JDiffraction, a GPGPU-accelerated JAVA library for numerical propagation of scalar wave fields, is presented. Angular spectrum, Fresnel transform, and Fresnel-Bluestein transform are the numerical algorithms implemented in the methods and functions of the library to compute the scalar propagation of the complex wavefield. The functionality of the library is tested with the modeling of easy to forecast numerical experiments and also with the numerical reconstruction of a digitally recorded hologram. The performance of JDiffraction is contrasted with a library written for C++, showing great competitiveness in the apparently less complex environment of JAVA language. JDiffraction also includes JAVA easy-to-use methods and functions that take advantage of the computation power of the graphic processing units to accelerate the processing times of 2048×2048 pixel images up to 74 frames per second.

Graphic overview system for DOE's effluent and environmental monitoring programs