WorldWideScience

Sample records for grand challenge electron

  1. Coordinated Exploration for Grand Challenges

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders; Sofka, Wolfgang; Grimpe, Christoph

    2016-01-01

    Grand challenges are among the most complex problems for modern societies. Many governments and foundations provide substantial resources to encourage the search for solutions. Due to the significance of these problems, organizations often form partnerships in what we call search consortia to eng...

  2. Grand Challenges of Enterprise Integration

    Energy Technology Data Exchange (ETDEWEB)

    Brosey, W.D; Neal, R.E.; Marks, D.

    2001-04-01

    Enterprise Integration connects and combines people, processes, systems, and technologies to ensure that the right people and the right processes have the right information and the right resources at the right time. A consensus roadmap for Technologies for Enterprise Integration was created as part of an industry/government/academia partnership in the Integrated Manufacturing Technology Initiative (IMTI). Two of the grand challenges identified by the roadmapping effort will be addressed here--Customer Responsive Enterprises and Totally Connected Enterprises. Each of these challenges is briefly discussed as to the current state of industry and the future vision as developed in the roadmap.

  3. Grand Challenges for Environmental Magnetism

    Science.gov (United States)

    Verosub, K. L.

    2009-05-01

    The development of new, inexpensive, and rapid geochemical methods for determining the ages of geologic materials, their elemental composition, and their isotopic ratios over a broad array of elements puts into sharp focus the question: What information can environmental magnetic methods provide that can't be obtained using these other methods? Because iron is ubiquitous in the Earth's crust and because it exists in so many different forms, a discipline that looks in detail at iron-bearing minerals does have the potential to make significant contributions to the study of surficial processes. However, to reach that potential requires the development of new environmental magnetic methods. I would like to put forward three Grand Challenges for environmental magnetism that have the potential to move the field forward to a new level of scientific sophistication and that will allow environmental magnetists to compete successfully in a world increasingly dominated by geochemists. The first Grand Challenge is the development of new techniques that lead to the direct and unambiguous identification of the full suite of magnetic minerals. For many environmental magnetic applications, the key magnetic minerals are not just magnetite and hematite but also iron oxy-hydroxides (goethite, lepidocrocite, akaganeite, ferrihydrite), carbonates (siderite) and sulfides (pyrrhotite and greigite) as well as compounds involving iron and other transition metals (cobalt and nickel). The second Grand Challenge is the development of new analytical methods that provide specific quantitative values for the amount of each magnetic mineral present in a sample. One promising approach to this problem is the application of two- or three-component multivariate analysis to arrays of downcore environmental magnetic parameters. The third Grand Challenge is the development of new ways of determining, not just the average values, but the actual distributions of grain sizes and coercivities of each mineral

  4. The Grand Challenges of Nanotechnology

    International Nuclear Information System (INIS)

    Lane, Neal

    2001-01-01

    Amazing breakthroughs and advances continue to be made in nanoscale science and engineering and the rapidly emerging field of nanotechnology, including near-commercial applications in biomedicine, computing and environmental protection. The National Nanotechnology Initiative, begun by the Clinton Administration has placed nanoscale research on a new funding trajectory. But, many 'grand challenges' must be overcome, technical ones as well as those related to funding, science and technology workforce, and the need for stronger collaboration across discipline, organizations, government agencies and with other countries

  5. Next Generation Innovation Policy and Grand Challenges

    NARCIS (Netherlands)

    Kuhlmann, Stefan; Rip, Arie

    2018-01-01

    The paper explores transformative ways to address Grand Challenges, while locating them in a broader diagnosis of ongoing changes. Coping with Grand Challenges is a challenge in its own right, for policy as well as for science, technology, and innovation actors. The paper presents building blocks

  6. 2010 Panel on the Biomaterials Grand Challenges

    Science.gov (United States)

    Reichert, William “Monty”; Ratner, Buddy D.; Anderson, James; Coury, Art; Hoffman, Allan S.; Laurencin, Cato T.; Tirrell, David

    2014-01-01

    In 2009, the National Academy for Engineering issued the Grand Challenges for Engineering in the 21st Century comprised of 14 technical challenges that must be addressed to build a healthy, profitable, sustainable, and secure global community (http://www.engineeringchallenges.org). Although crucial, none of the NEA Grand Challenges adequately addressed the challenges that face the biomaterials community. In response to the NAE Grand Challenges, Monty Reichert of Duke University organized a panel entitled Grand Challenges in Biomaterials at the at the 2010 Society for Biomaterials Annual Meeting in Seattle. Six members of the National Academies—Buddy Ratner, James Anderson, Allan Hoffman, Art Coury, Cato Laurencin, and David Tirrell—were asked to propose a grand challenge to the audience that, if met, would significantly impact the future of biomaterials and medical devices. Successfully meeting these challenges will speed the 60-plus year transition from commodity, off-the-shelf biomaterials to bioengineered chemistries, and biomaterial devices that will significantly advance our ability to address patient needs and also to create new market opportunities. PMID:21171147

  7. Grand Challenges facing Storage Systems

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    In this talk, we will discuss the future of storage systems. In particular, we will focus on several big challenges which we are facing in storage, such as being able to build, manage and backup really massive storage systems, being able to find information of interest, being able to do long-term archival of data, and so on. We also present ideas and research being done to address these challenges, and provide a perspective on how we expect these challenges to be resolved as we go forward.

  8. Grand Challenges in Music Information Research

    OpenAIRE

    Goto, Masataka

    2012-01-01

    This paper discusses some grand challenges in which music information research will impact our daily lives and our society in the future. Here, some fundamental questions are how to provide the best music for each person, how to predict music trends, how to enrich human-music relationships, how to evolve new music, and how to address environmental, energy issues by using music technologies. Our goal is to increase both attractiveness and social impacts of music information research in the fut...

  9. Workshop and conference on Grand Challenges applications and software technology

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    On May 4--7, 1993, nine federal agencies sponsored a four-day meeting on Grand Challenge applications and software technology. The objective was to bring High-Performance Computing and Communications (HPCC) Grand Challenge applications research groups supported under the federal HPCC program together with HPCC software technologists to: discuss multidisciplinary computational science research issues and approaches, identify major technology challenges facing users and providers, and refine software technology requirements for Grand Challenge applications research. The first day and a half focused on applications. Presentations were given by speakers from universities, national laboratories, and government agencies actively involved in Grand Challenge research. Five areas of research were covered: environmental and earth sciences; computational physics; computational biology, chemistry, and materials sciences; computational fluid and plasma dynamics; and applications of artificial intelligence. The next day and a half was spent in working groups in which the applications researchers were joined by software technologists. Nine breakout sessions took place: I/0, Data, and File Systems; Parallel Programming Paradigms; Performance Characterization and Evaluation of Massively Parallel Processing Applications; Program Development Tools; Building Multidisciplinary Applications; Algorithm and Libraries I; Algorithms and Libraries II; Graphics and Visualization; and National HPCC Infrastructure.

  10. EV Everywhere Grand Challenge Road to Success

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2014-01-31

    Initial progress report for EV Everywhere. The report highlights the significant cost reduction in batteries in 2014, which will enable increased PEV affordability for consumers. Also, the efforts on increasing the convenience of PEVs through the Workplace Charging Challenge, which called on U.S. employers to help develop the nation's charging infrastructure.

  11. Grand societal challenges in information systems research and education

    CERN Document Server

    vom Brocke, Jan; Hofmann, Sara; Tumbas, Sanja

    2015-01-01

    This book examines how information systems research and education can play a major role in contributing to solutions to the Societal Grand Challenges formulated in "The Millennium Project" (millenium-project.org). Individual chapters focus on specific challenges, review existing approaches and contributions towards solutions in information systems research and outline a research agenda for these challenges. The topics considered in this volume range from climate change, population growth, global ICT availability, breakthroughs in science and technology and energy demand to ethical decision-making, policymaking, gender status and transnational crime prevention. It is the first book to present ideas on how the Information Systems discipline can contribute to the solution on this wide spectrum of grand societal challenges.

  12. Grand challenges for integrated USGS science—A workshop report

    Science.gov (United States)

    Jenni, Karen E.; Goldhaber, Martin B.; Betancourt, Julio L.; Baron, Jill S.; Bristol, R. Sky; Cantrill, Mary; Exter, Paul E.; Focazio, Michael J.; Haines, John W.; Hay, Lauren E.; Hsu, Leslie; Labson, Victor F.; Lafferty, Kevin D.; Ludwig, Kristin A.; Milly, Paul C. D.; Morelli, Toni L.; Morman, Suzette A.; Nassar, Nedal T.; Newman, Timothy R.; Ostroff, Andrea C.; Read, Jordan S.; Reed, Sasha C.; Shapiro, Carl D.; Smith, Richard A.; Sanford, Ward E.; Sohl, Terry L.; Stets, Edward G.; Terando, Adam J.; Tillitt, Donald E.; Tischler, Michael A.; Toccalino, Patricia L.; Wald, David J.; Waldrop, Mark P.; Wein, Anne; Weltzin, Jake F.; Zimmerman, Christian E.

    2017-06-30

    Executive SummaryThe U.S. Geological Survey (USGS) has a long history of advancing the traditional Earth science disciplines and identifying opportunities to integrate USGS science across disciplines to address complex societal problems. The USGS science strategy for 2007–2017 laid out key challenges in disciplinary and interdisciplinary arenas, culminating in a call for increased focus on a number of crosscutting science directions. Ten years on, to further the goal of integrated science and at the request of the Executive Leadership Team (ELT), a workshop with three dozen invited scientists spanning different disciplines and career stages in the Bureau convened on February 7–10, 2017, at the USGS John Wesley Powell Center for Analysis and Synthesis in Fort Collins, Colorado.The workshop focused on identifying “grand challenges” for integrated USGS science. Individual participants identified nearly 70 potential grand challenges before the workshop and through workshop discussions. After discussion, four overarching grand challenges emerged:Natural resource security,Societal risk from existing and emerging threats,Smart infrastructure development, andAnticipatory science for changing landscapes.Participants also identified a “comprehensive science challenge” that highlights the development of integrative science, data, models, and tools—all interacting in a modular framework—that can be used to address these and other future grand challenges:Earth Monitoring, Analyses, and Projections (EarthMAP)EarthMAP is our long-term vision for an integrated scientific framework that spans traditional scientific boundaries and disciplines, and integrates the full portfolio of USGS science: research, monitoring, assessment, analysis, and information delivery.The Department of Interior, and the Nation in general, have a vast array of information needs. The USGS meets these needs by having a broadly trained and agile scientific workforce. Encouraging and supporting

  13. US DOE Grand Challenge in Computational Accelerator Physics

    International Nuclear Information System (INIS)

    Ryne, R.; Habib, S.; Qiang, J.; Ko, K.; Li, Z.; McCandless, B.; Mi, W.; Ng, C.; Saparov, M.; Srinivas, V.; Sun, Y.; Zhan, X.; Decyk, V.; Golub, G.

    1998-01-01

    Particle accelerators are playing an increasingly important role in basic and applied science, and are enabling new accelerator-driven technologies. But the design of next-generation accelerators, such as linear colliders and high intensity linacs, will require a major advance in numerical modeling capability due to extremely stringent beam control and beam loss requirements, and the presence of highly complex three-dimensional accelerator components. To address this situation, the U.S. Department of Energy has approved a ''Grand Challenge'' in Computational Accelerator Physics, whose primary goal is to develop a parallel modeling capability that will enable high performance, large scale simulations for the design, optimization, and numerical validation of next-generation accelerators. In this paper we report on the status of the Grand Challenge

  14. Engineering grand challenges and the attributes of the global engineer

    DEFF Research Database (Denmark)

    Guerra, Aida; Ulseth, Ron; Jonhson, Bart

    2017-01-01

    Technology has been changing world in ways never imagined. The ever-evolving society and rapid development posed different demands and challenges to the engineering profession. Addressing these challenges means to re-vision and reform the ways we educate future engineers and the attributes need...... to be enhanced. This paper reports a literature review with aim to (1) understand the different stakeholders’ perspectives, namely students, educators, and employers, (2) understand the profile of the global engineer (i.e. knowledge, competences and skills), and (3) outline and discuss learning strategies....... As a result, the paper presents the main gaps in the existing knowledge, formulates research hypothesis, and proposes a research design for a follow up empirical study to investigate further the engineering grand challenges, the attributes needed to solve them, and the learning environments required....

  15. Is it possible to give scientific solutions to Grand Challenges? On the idea of grand challenges for life science research.

    Science.gov (United States)

    Efstathiou, Sophia

    2016-04-01

    This paper argues that challenges that are grand in scope such as "lifelong health and wellbeing", "climate action", or "food security" cannot be addressed through scientific research only. Indeed scientific research could inhibit addressing such challenges if scientific analysis constrains the multiple possible understandings of these challenges into already available scientific categories and concepts without translating between these and everyday concerns. This argument builds on work in philosophy of science and race to postulate a process through which non-scientific notions become part of science. My aim is to make this process available to scrutiny: what I call founding everyday ideas in science is both culturally and epistemologically conditioned. Founding transforms a common idea into one or more scientifically relevant ones, which can be articulated into descriptively thicker and evaluatively deflated terms and enable operationalisation and measurement. The risk of founding however is that it can invisibilise or exclude from realms of scientific scrutiny interpretations that are deemed irrelevant, uninteresting or nonsensical in the domain in question-but which may remain salient for addressing grand-in-scope challenges. The paper considers concepts of "wellbeing" in development economics versus in gerontology to illustrate this process. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Fostering Scientific Literacy: Establishing Social Relevance via the Grand Challenges

    Science.gov (United States)

    Lyford, M. E.; Myers, J. D.; Buss, A.

    2010-12-01

    Numerous studies and polls suggest the general public’s understanding of science and scientific literacy remain woefully inadequate despite repeated calls for improvement over the last 150 years. This inability to improve scientific literacy significantly is a complex problem likely driven by a number of factors. However, we argue that past calls and efforts for improving scientific literacy have failed to: 1) articulate a truly meaningful justification for society to foster a scientifically literate public; 2) provide a rationale that motivates individuals of diverse backgrounds to become scientifically literate; 3) consider the impact of personal perspective, e.g. values, beliefs, attitudes, etc., on learning; and 4) offer a relevant and manageable framework in which to define scientific literacy. For instance, past calls for improving scientific literacy, e.g. the U.S. is behind the Soviets in the space race, U.S students rank below country X in math and science, etc., have lacked justification, personal motivation and a comprehensive framework for defining scientific literacy. In these cases, the primary justification for improving science education and scientific literacy was to regain international dominance in the space race or to advance global standing according to test results. These types of calls also articulate short-term goals that are rendered moot once they have been achieved. At the same time, teaching practices have commonly failed to consider the perspectives students bring to the classroom. Many STEM faculty do not address issues of personal perspective through ignorance or the desire to avoid controversial subjects, e g. evolution, climate change. We propose that the ‘grand challenges’ (e.g., energy, climate change, antibacterial resistance, water, etc.) humankind currently faces provides a compelling framework for developing courses and curricula well-suited for improving scientific literacy. A grand challenge paradigm offers four

  17. Bringing Seismology's Grand Challenges to the Undergraduate Classroom

    Science.gov (United States)

    Benoit, M. H.; Taber, J.; Hubenthal, M.

    2011-12-01

    The "Seismological Grand Challenges in Understanding Earth's Dynamic Systems," a community-written long-range science plan for the next decade, poses 10 questions to guide fundamental seismological research. Written in an approachable fashion suitable for policymakers, the broad questions and supporting discussion contained in this document offer an ideal framework for the development of undergraduate curricular materials. Leveraging this document, we have created a collection of inquiry-based classroom modules that utilize authentic data to modernize seismological instruction in 100 and 200 level undergraduate courses. The modules not only introduce undergraduates to the broad questions that the seismological community seeks to answer in the future but also showcase the numerous areas where modern seismological research is actively contributing to our understanding of fundamental Earth processes. To date 6 in-depth explorations that correspond to the Grand Challenges document have been developed. The specific topics for each exploration were selected to showcase modern seismological research while also covering topics commonly included in the curriculum of these introductory classes. Examples of activities that have been created and their corresponding Grand Challenge include: -A guided inquiry that introduces students to episodic tremor and slip and compares the GPS and seismic signatures of ETS with those produced from standard tectonic earthquakes (Grand Challenge "How do faults slip?"). - A laboratory exercise where students engage in b-value mapping of volcanic earthquakes to assess potential eruption hazards (How do magmas ascend and erupt?). - A module that introduce students to glacial earthquakes in Greenland and compares their frequency and spatial distribution to tectonic earthquakes (How do processes in the ocean and atmosphere interact with the solid Earth?). What is the relationship between stress and strain in the lithosphere? - An activity that

  18. Grand Challenges in Clinical Decision Support v10

    Science.gov (United States)

    Sittig, Dean F.; Wright, Adam; Osheroff, Jerome A.; Middleton, Blackford; Teich, Jonathan M.; Ash, Joan S.; Campbell, Emily; Bates, David W.

    2008-01-01

    There is a pressing need for high-quality, effective means of designing, developing, presenting, implementing, evaluating, and maintaining all types of clinical decision support capabilities for clinicians, patients and consumers. Using an iterative, consensus-building process we identified a rank-ordered list of the top 10 grand challenges in clinical decision support. This list was created to educate and inspire researchers, developers, funders, and policy-makers. The list of challenges in order of importance that they be solved if patients and organizations are to begin realizing the fullest benefits possible of these systems consists of: Improve the human-computer interface; Disseminate best practices in CDS design, development, and implementation; Summarize patient-level information; Prioritize and filter recommendations to the user; Create an architecture for sharing executable CDS modules and services; Combine recommendations for patients with co-morbidities; Prioritize CDS content development and implementation; Create internet-accessible clinical decision support repositories; Use freetext information to drive clinical decision support; Mine large clinical databases to create new CDS. Identification of solutions to these challenges is critical if clinical decision support is to achieve its potential and improve the quality, safety and efficiency of healthcare. PMID:18029232

  19. First-Year Students' Attitudes towards the Grand Challenges and Nanotechnology

    Science.gov (United States)

    Lakin, Joni M.; Han, Yi; Davis, Edward

    2016-01-01

    The "Grand Challenges" for Engineering are an effort to portray engineering as a field that has profound impacts on society. This study explores the level of interest first-year engineering students had in various "Grand Challenges" and in nanotechnology topics. We administered a survey to a large sample of students enrolled in…

  20. On the Grand Challenges in Physical Petrology: the Multiphase Crossroads

    Science.gov (United States)

    Bergantz, G. W.

    2014-12-01

    Rapid progress in experimental, micro-analytical and textural analysis at the crystal scale has produced an unprecedented record of magmatic processes. However an obstacle to further progress is the lack of understanding of how mass, energy and momentum flux associated with crystal-rich, open-system events produces identifiable outcomes. Hence developing a physically-based understanding of magmatic systems linking micro-scale petrological observations with a physical template operating at the macro-scale presents a so-called "Grand Challenge." The essence of this challenge is that magmatic systems have characteristic length and feedback scales between those accessible by classical continuum and discrete methods. It has become increasingly obvious that the old-school continuum methods have limited resolution and power of explanation for multiphase (real) magma dynamics. This is, in part, because in crystal-rich systems the deformation is non-affine, and so the concept of constitutive behavior is less applicable and likely not even relevant, especially if one is interested in the emergent character of micro-scale processes. One expression of this is the cottage industry of proposing viscosity laws for magmas, which serves as "blunt force" de facto corrections for what is intrinsically multiphase behavior. Even in more fluid-rich systems many of these laws are not suitable for use in the very transport theories they aim to support. The alternative approach is the discrete method, where multiphase interactions are explicitly resolved. This is a daunting prospect given the numbers of crystals in magmas. But perhaps all crystals don't need to be modeled. I will demonstrate how discrete methods can recover critical state behavior, resolve crystal migration, the onset of visco-elastic behavior such as melt-present shear bands which sets the large-scale mixing volumes, some of the general morpho-dynamics that underlies purported rheological models, and transient controls on

  1. Analysis of the mass media coverage of the Gates Foundation grand challenges in global health initiative.

    Science.gov (United States)

    Verma, G

    2009-03-01

    The Grand Challenges were launched in 2003 by the Gates Foundation and other collaborators to address the health needs of developing countries. This paper outlines the current problem with health research and development in the context of inequality as conveyed by the 90/10 divide. The paper then looks at the focus and nature of press reporting of global health issues by analysing how press articles have portrayed the Grand Challenges in Global Health initiative. Analysis of the mass media illustrates that the focus of reporting on the Grand Challenges tends to be on utilitarian themes, leaving issues related to justice and equity comparatively under-reported.

  2. Grand challenge problems in environmental modeling and remediation: Groundwater contaminant transport. Final project report 1998

    International Nuclear Information System (INIS)

    1998-04-01

    The over-reaching goal of the Groundwater Grand Challenge component of the Partnership in Computational Science (PICS) was to develop and establish the massively parallel approach for the description of groundwater flow and transport and to address the problem of uncertainties in the data and its interpretation. This necessitated the development of innovative algorithms and the implementation of massively parallel computational tools to provide a suite of simulators for groundwater flow and transport in heterogeneous media. This report summarizes the activities and deliverables of the Groundwater Grand Challenge project funded through the High Performance Computing grand challenge program of the Department of Energy from 1995 through 1997

  3. A BLUEPRINT FOR IMPLEMENTING GRAND CHALLENGE SCHOLARS’ PROGRAMME: A CASE STUDY OF TAYLOR’S UNIVERSITY

    Directory of Open Access Journals (Sweden)

    MUSHTAK AL-ATABI

    2013-04-01

    Full Text Available The National Academy for Engineering announced 14 Grand Challenges for the 21st Century engineers to address in order to ensure a sustainable future for the generations to come. These grand challenges are in four broad areas, namely, energy and environment, health, security and learning and computation. This paper reports on a Grand Challenges Scholars’ Programme that is developed to prepare the engineering students to be able to address the grand challenges using the CDIO framework and focusing on five components; research experience, interdisciplinary curriculum, entrepreneurship, global dimension and service learning. The programme is voluntary and the candidates are expected to commit additional learning time. The programme was launched with 16 participants who are expected to graduate in 2016. A preliminary assessment of the programs shows that the participants found the programme useful in developing an array of CDIO skills. The School intends to continue offering this programme with the intention of integrating it with a holistic education approach.

  4. Grand challenges in technology enhanced learning outcomes of the 3rd Alpine Rendez-Vous

    CERN Document Server

    Fischer, Frank; Sutherland, Rosamund; Zirn, Lena

    2014-01-01

    This book presents a key piece of the vision and strategy developed in STELLAR. It sets out a new mid-term agenda by defining Grand Challenges for research and development in technology-enhanced learning. Other than mere technology prizes, STELLAR Grand Challenges deal with problems at the interface of social and technical sciences. They pose problems that can be solved only in interdisciplinary collaboration. The descriptions of the Grand Challenge Problems were sent out to a number of stakeholders from industry, academia, and policy-making who responded with insightful, creative and critical comments bringing in their specific perspectives. This book will inspire everyone interested in TEL and its neighboring disciplines in their future projects. All of the listed problems, first hints with respect to the approach, measurable success indicators and funding sources are outlined. The challenges focus on what noted experts regard as important upcoming, pending, and innovative fields of research, the solution o...

  5. Grand Challenges and Great Potential in Foreign Language Teaching and Learning

    Science.gov (United States)

    Hlas, Anne Cummings

    2018-01-01

    This article argues for the field of foreign languages to begin to identify and define our Grand Challenges, which are difficult yet solvable problems facing our field. Seeking answers to these challenges can provide new opportunities for collaboration and can spur new directions and innovation within language learning and teaching. Researchable…

  6. A Library in the Grands Moulins de Paris: challenging Reality

    Directory of Open Access Journals (Sweden)

    Catherine Tresson

    2006-07-01

    Full Text Available In 2006, the University of Paris 7 and its new Main Library will move to Paris Rive Gauche, a recently developed neighbourhood on the left bank of the Seine. The library will occupy most of the city’s former industrial mills, the Grands Moulins de Paris. As part of the project, the library developed a very detailed functional program. The facilities are expected to comprise 1,800 workstations (half of which will be computerized, and upon completion will have a capacity of 300,000 freely accessible documents and 350,000 documents in store over a total surface area of some 12,000 m2. The architect Rudy Ricciotti won the international competition to design the library held in 2001. Perfectly suited to its function, the industrial building in which the library is housed dates from the 1920s. It presents both advantages (vast surfaces, sufficient load-bearing capacity, natural light, etc. and obstacles (restrictions on free circulation, forests of columns in certain areas, interrupted spaces, etc. to being transformed into a library that is functional and adapted to its purposes. The building’s structure and the constraints it imposed profoundly influenced the program which had to be adjusted, and also affected other aspects, including the arrangement and features of the furnishings as well as the building’s system of signs. In agreement with the university, the library worked in close collaboration with the architect from the earliest sketches onwards. As a result, his initial plan also evolved considerably. The installation of the library in the Grands Moulins offers us a chance to observe the nature and effects of the interactions between the transformation of a building and the evolution of a program.

  7. Sustainable Materials Management (SMM) Electronics Challenge

    Science.gov (United States)

    Learn how the SMM Electronics Challenge encourage electronic manufacturers to strive to send 100 percent of the used electronics they collect from the public and retailers to certified electronics refurbishers and recyclers.

  8. Grand challenge commentary: Transforming biosynthesis into an information science.

    Science.gov (United States)

    Bayer, Travis S

    2010-12-01

    Engineering biosynthetic pathways to natural products is a challenging endeavor that promises to provide new therapeutics and tools to manipulate biology. Information-guided design strategies and tools could unlock the creativity of a wide spectrum of scientists and engineers by decoupling expertise from implementation.

  9. Sustainable Materials Management (SMM) Electronics Challenge Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — On September 22, 2012, EPA launched the SMM Electronics Challenge. The Challenge encourages electronics manufacturers, brand owners and retailers to strive to send...

  10. Grand Challenges and Chemical Engineering Curriculum--Developments at TU Dortmund University

    Science.gov (United States)

    Kockmann, Norbert; Lutze, Philip; Gorak, Andrzej

    2016-01-01

    Chemical processing industry is progressively focusing their research activities and product placements in the areas of Grand Challenges (or Global Megatrends) such as mobility, energy, communication, or health care and food. Innovation in all these fields requires solving high complex problems, rapid product development as well as dealing with…

  11. Promoting Collaborative Problem-Solving Skills in a Course on Engineering Grand Challenges

    Science.gov (United States)

    Zou, Tracy X. P.; Mickleborough, Neil C.

    2015-01-01

    The ability to solve problems with people of diverse backgrounds is essential for engineering graduates. A course on engineering grand challenges was designed to promote collaborative problem-solving (CPS) skills. One unique component is that students need to work both within their own team and collaborate with the other team to tackle engineering…

  12. Megatrends and grand challenges of cybercrime and cyberterrorism policy and research

    NARCIS (Netherlands)

    Koops, Bert Jaap; Akhgar, Babak; Brewster, Ben

    2016-01-01

    What are grand challenges of cybercrime and cyberterrorism policy and research for the coming one or two decades? To answer this question, we first need to grasp some major trends that influence the future of cybercrime and cyberterrorism, and the combatting thereof, in fundamental ways. This

  13. Management as a science-based profession: a grand societal challenge

    NARCIS (Netherlands)

    Romme, A.G.L.

    2017-01-01

    The purpose of this paper is to explore how the quest for management as a science-based profession, conceived as a grand societal challenge, can be revitalized. A reflective approach is adopted by questioning some of the key assumptions made by management scholars, especially those that undermine

  14. 75 FR 5634 - Grand Challenges of the 21st Century; Request for Information

    Science.gov (United States)

    2010-02-03

    ... careers in science, technology, engineering, and mathematics. There are multiple types of grand challenges. Some define important problems in a particular field of science and engineering. For example, in 1900... as those identified by the National Academy of Engineering; (3) partners (e.g., companies, investors...

  15. Grand challenge problems in environmental modeling and remediation: groundwater contaminant transport

    Energy Technology Data Exchange (ETDEWEB)

    Todd Arbogast; Steve Bryant; Clint N. Dawson; Mary F. Wheeler

    1998-08-31

    This report describes briefly the work of the Center for Subsurface Modeling (CSM) of the University of Texas at Austin (and Rice University prior to September 1995) on the Partnership in Computational Sciences Consortium (PICS) project entitled Grand Challenge Problems in Environmental Modeling and Remediation: Groundwater Contaminant Transport.

  16. Biological approaches for addressing the grand challenge of providing access to clean drinking water

    Science.gov (United States)

    2011-01-01

    The U.S. National Academy of Engineering (NAE) recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF). Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of providing access to clean drinking water. This issue must be addressed in part by removing or inactivating microbial and chemical contaminants in order to properly deliver water safe for human consumption. Despite many advances in technologies this challenge is expanding due to increased pressure on fresh water supplies and to new opportunities for growth of potentially pathogenic organisms. PMID:21453515

  17. Using Grand Challenges to Teach Science: A Biology-Geology Collaboration

    Science.gov (United States)

    Lyford, M.; Myers, J. D.

    2012-12-01

    Three science courses at the University of Wyoming explore the inextricable connections between science and society by centering on grand challenges. Two of these courses are introductory integrated science courses for non-majors while the third is an upper level course for majors and non-majors. Through collaboration, the authors have developed these courses to explore the grand challenges of energy, water and climate. Each course focuses on the fundamental STEM principles required for a citizen to understand each grand challenge. However, the courses also emphasize the non-STEM perspectives (e.g., economics, politics, human well-being, externalities) that underlie each grand challenge and argue that creating equitable, sustainable and just solutions to the grand challenges hinges on an understanding of STEM and non-STEM perspectives. Moreover, the authors also consider the multitude of personal perspectives individuals bring to the classroom (e.g., values, beliefs, empathy misconceptions) that influence any stakeholder's ability to engage in fruitful discussions about grand challenge solutions. Discovering Science (LIFE 1002) focuses on the grand challenges of energy and climate. Students attend three one-hour lectures, one two-hour lab and a one-hour discussion each week. Lectures emphasize the STEM and non-STEM principles underlying each grand challenge. Laboratory activities are designed to be interdisciplinary and engage students in inquiry-driven activities to reinforce concepts from lecture and to model how science is conducted. Labs also expose students to the difficulties often associated with scientific studies, the limits of science, and the inherent uncertainties associated with scientific findings. Discussion sessions provide an opportunity for students to explore the complexity of the grand challenges from STEM and non-STEM perspectives, and expose the multitude of personal perspectives an individual might harbor related to each grand challenge

  18. A Grand Challenge for CMOS Scaling: Alternate Gate Dielectrics

    Science.gov (United States)

    Wallace, Robert M.

    2001-03-01

    Many materials systems are currently under consideration as potential replacements for SiO2 as the gate dielectric material for sub-0.13 um complementary metal oxide semiconductor (CMOS) technology. The prospect of replacing SiO2 is a formidable task because the alternate gate dielectric must provide many properties that are, at a minimum, comparable to those of SiO2 yet with a much higher permittivity. A systematic examination of the required performance of gate dielectrics suggests that the key properties to consider in the selection an alternative gate dielectric candidate are (a) permittivity, band gap and band alignment to silicon, (b) thermodynamic stability, (c) film morphology, (d) interface quality, (e) compatibility with the current or expected materials to be used in processing for CMOS devices, (f) process compatibility, and (g) reliability. Many dielectrics appear favorable in some of these areas, but very few materials are promising with respect to all of these guidelines. We will review the performance requirements for materials associated with CMOS scaling, the challenges associated with these requirements, and the state-of-the-art in current research for alternate gate dielectrics. The requirements for process integration compatibility are remarkably demanding, and any serious candidates will emerge only through continued, intensive investigation.

  19. Building a Course on Global Sustainability using the grand challenges of Energy-Water-Climate

    Science.gov (United States)

    Myers, J. D.

    2012-12-01

    GEOL1600: Global Sustainability: Managing the Earth's Resources is a lower division integrated science course at the University of Wyoming that fulfills the university's science requirement. Course content and context has been developed using the grand challenge nexus of energy-water-and climate (EWC). The interconnection of these issues, their social relevance and timeliness has provided a framework that gives students an opportunity to recognize why STEM is relevant to their lives regardless of their ultimate professional career choices. The EWC nexus provides the filter to sieve the course's STEM content. It also provides an ideal mechanism by which the non-STEM perspectives important in grand challenge solutions can be seamlessly incorporated in the course. Through a combination of content and context, the relevance of these issues engage students in their own learning. Development of the course followed the Grand Challenge Scientific Literacy (GCSL) model independently developed by the author and two colleagues at the University of Wyoming. This course model stresses science principles centered on the nature of science (e.g., fundamental premises, habits of mind, critical thinking) and unifying scientific concepts (e.g., methods and tools, experimentation, modeling). Grand challenge principles identify the STEM and non-STEM concepts needed to understand the grand challenges, drawing on multiple STEM and non-STEM disciplines and subjects (i.e., economics, politics, unintended consequences, roles of stakeholders). Using the EWC nexus filter and building on the Grand Challenge Principles, specific content included in the course is selected is that most relevant to understanding the Grand Challenges, thereby stressing content depth over breadth. Because quantitative data and reasoning is critical to effectively evaluating challenge solutions, QR is a component of nearly all class activities, while engineering and technology aspects of grand challenges are

  20. The grand challenge of managing the petascale facility.

    Energy Technology Data Exchange (ETDEWEB)

    Aiken, R. J.; Mathematics and Computer Science

    2007-02-28

    This report is the result of a study of networks and how they may need to evolve to support petascale leadership computing and science. As Dr. Ray Orbach, director of the Department of Energy's Office of Science, says in the spring 2006 issue of SciDAC Review, 'One remarkable example of growth in unexpected directions has been in high-end computation'. In the same article Dr. Michael Strayer states, 'Moore's law suggests that before the end of the next cycle of SciDAC, we shall see petaflop computers'. Given the Office of Science's strong leadership and support for petascale computing and facilities, we should expect to see petaflop computers in operation in support of science before the end of the decade, and DOE/SC Advanced Scientific Computing Research programs are focused on making this a reality. This study took its lead from this strong focus on petascale computing and the networks required to support such facilities, but it grew to include almost all aspects of the DOE/SC petascale computational and experimental science facilities, all of which will face daunting challenges in managing and analyzing the voluminous amounts of data expected. In addition, trends indicate the increased coupling of unique experimental facilities with computational facilities, along with the integration of multidisciplinary datasets and high-end computing with data-intensive computing; and we can expect these trends to continue at the petascale level and beyond. Coupled with recent technology trends, they clearly indicate the need for including capability petascale storage, networks, and experiments, as well as collaboration tools and programming environments, as integral components of the Office of Science's petascale capability metafacility. The objective of this report is to recommend a new cross-cutting program to support the management of petascale science and infrastructure. The appendices of the report document current and projected

  1. The Grand Challenges Discourse: Transforming Identity Work in Science and Science Policy.

    Science.gov (United States)

    Kaldewey, David

    2018-01-01

    This article analyzes the concept of "grand challenges" as part of a shift in how scientists and policymakers frame and communicate their respective agendas. The history of the grand challenges discourse helps to understand how identity work in science and science policy has been transformed in recent decades. Furthermore, the question is raised whether this discourse is only an indicator, or also a factor in this transformation. Building on conceptual history and historical semantics, the two parts of the article reconstruct two discursive shifts. First, the observation that in scientific communication references to "problems" are increasingly substituted by references to "challenges" indicates a broader cultural trend of how attitudes towards what is problematic have shifted in the last decades. Second, as the grand challenges discourse is rooted in the sphere of sports and competition, it introduces a specific new set of societal values and practices into the spheres of science and technology. The article concludes that this process can be characterized as the sportification of science, which contributes to self-mobilization and, ultimately, to self-optimization of the participating scientists, engineers, and policymakers.

  2. A Grand Challenge: Immortal Information and Through-Life Knowledge Management (KIM

    Directory of Open Access Journals (Sweden)

    Alexander Ball

    2006-11-01

    Full Text Available ‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating substantial industry collaboration. It is investigating a range of issues associated with the move towards a product-service paradigm in the engineering sector, in particular the long-term curation of digital data, learning from production and use, and appropriate governance and management techniques.

  3. The Grand Canyon of the Colorado: a challenge to float, a challenge to manage

    Science.gov (United States)

    David N. Cole

    1989-01-01

    Last summer, I finally got my chance to float the Colorado River through the Grand Canyon, one of the world’s premier adventure trips. For 18 days and 280 miles, my group floated through some of the most spectacular scenery imaginable, spacing our days with hikes through slickrock alcoves, along terraced pools of blue-green water, to waterfalls plunging out of holes on...

  4. Grand Challenges Canada: inappropriate emphasis and missed opportunities in global health research?

    Science.gov (United States)

    Larson, Charles P; Haddad, Slim; Birn, Anne-Emanuelle; Cole, Donald C; Labonte, Ronald; Roberts, Janet Hatcher; Schrecker, Ted; Sellen, Daniel; Zakus, David

    2011-01-01

    In May 2010, Grand Challenges Canada (GCC) was launched with the mandate to identify global challenges in health that could be supported through the Government of Canada's Development Innovations Fund (DIF: $225 million over five years). The GCC offers a potentially excellent mechanism for taking Canada's participation in global health challenges "to a higher level". Recent GCC announcements raise new questions about the emphasis being placed on technological discovery or "catalytic" research. Missing so far are opportunities that the Fund could offer in order to support innovative research addressing i) health systems strengthening, ii) more effective delivery of existing interventions, and iii) policies and programs that address broader social determinants of health. The Canadian Grand Challenges announced to date risk pushing to the sidelines good translational and implementation science and early career-stage scientists addressing important social, environmental and political conditions that affect disease prevalence, progress and treatment; and the many unresolved challenges faced in bringing to scale proven interventions within resource-constrained health systems. We wish to register our concern at the apparent prioritization of biotechnical innovation research and the subordination of the social, environmental, economic and political context in which human health is either protected or eroded.

  5. A different challenge: the directional drilled crossing for the Yacuiba - Rio Grande Gas Line Project - GASYRG

    Energy Technology Data Exchange (ETDEWEB)

    Green, Wayne; Garcia, Francisco [Bolinter Ltda., Santa Cruz (Bolivia); Montano, Ruben [Transierra, Santa Cruz (Bolivia)

    2003-07-01

    The Rio Grande River's directional drilling, 2002 m. long and 25 m. deep was a great challenge for Transierra - Owner - as well as Laney - Bolinter - Contractor - to accomplish a feat yet to be done in the entire world. The dedication of the people involved showed their degree of professionalism that these companies have obtained and the determination in doing the job overcoming unforeseen obstacles and still being able to finish on time, mitigating environmental impacts and leaving a first class crossing. This document presents a description of the technical, logistic and construction factors that were involved in the project and which allowed to perform 7 directional drillings, including Rio Grande River, which during the pull got the last 60 m. of pipe stuck, being freed only after using a pneumatic hammer. (author)

  6. Sustainable Materials Management (SMM) Electronics Challenge Data

    Science.gov (United States)

    On September 22, 2012, EPA launched the SMM Electronics Challenge. The Challenge encourages electronics manufacturers, brand owners and retailers to strive to send 100 percent of the used electronics they collect from the public, businesses and within their own organizations to third-party certified electronics refurbishers and recyclers. The Challenge??s goals are to: 1). Ensure responsible recycling through the use of third-party certified recyclers, 2). Increase transparency and accountability through public posting of electronics collection and recycling data, and 3). Encourage outstanding performance through awards and recognition. By striving to send 100 percent of used electronics collected to certified recyclers and refurbishers, Challenge participants are ensuring that the used electronics they collect will be responsibly managed by recyclers that maximize reuse and recycling, minimize exposure to human health and the environment, ensure the safe management of materials by downstream handlers, and require destruction of all data on used electronics. Electronics Challenge participants are publicly recognized on EPA's website as a registrant, new participant, or active participant. Awards are offered in two categories - tier and champion. Tier awards are given in recognition of achieving all the requirements under a gold, silver or bronze tier. Champion awards are given in two categories - product and non-product. For champion awards, a product is an it

  7. Grand canonical electronic density-functional theory: Algorithms and applications to electrochemistry

    International Nuclear Information System (INIS)

    Sundararaman, Ravishankar; Goddard, William A. III; Arias, Tomas A.

    2017-01-01

    First-principles calculations combining density-functional theory and continuum solvation models enable realistic theoretical modeling and design of electrochemical systems. When a reaction proceeds in such systems, the number of electrons in the portion of the system treated quantum mechanically changes continuously, with a balancing charge appearing in the continuum electrolyte. A grand-canonical ensemble of electrons at a chemical potential set by the electrode potential is therefore the ideal description of such systems that directly mimics the experimental condition. We present two distinct algorithms: a self-consistent field method and a direct variational free energy minimization method using auxiliary Hamiltonians (GC-AuxH), to solve the Kohn-Sham equations of electronic density-functional theory directly in the grand canonical ensemble at fixed potential. Both methods substantially improve performance compared to a sequence of conventional fixed-number calculations targeting the desired potential, with the GC-AuxH method additionally exhibiting reliable and smooth exponential convergence of the grand free energy. Lastly, we apply grand-canonical density-functional theory to the under-potential deposition of copper on platinum from chloride-containing electrolytes and show that chloride desorption, not partial copper monolayer formation, is responsible for the second voltammetric peak.

  8. Grand canonical electronic density-functional theory: Algorithms and applications to electrochemistry

    Science.gov (United States)

    Sundararaman, Ravishankar; Goddard, William A.; Arias, Tomas A.

    2017-03-01

    First-principles calculations combining density-functional theory and continuum solvation models enable realistic theoretical modeling and design of electrochemical systems. When a reaction proceeds in such systems, the number of electrons in the portion of the system treated quantum mechanically changes continuously, with a balancing charge appearing in the continuum electrolyte. A grand-canonical ensemble of electrons at a chemical potential set by the electrode potential is therefore the ideal description of such systems that directly mimics the experimental condition. We present two distinct algorithms: a self-consistent field method and a direct variational free energy minimization method using auxiliary Hamiltonians (GC-AuxH), to solve the Kohn-Sham equations of electronic density-functional theory directly in the grand canonical ensemble at fixed potential. Both methods substantially improve performance compared to a sequence of conventional fixed-number calculations targeting the desired potential, with the GC-AuxH method additionally exhibiting reliable and smooth exponential convergence of the grand free energy. Finally, we apply grand-canonical density-functional theory to the under-potential deposition of copper on platinum from chloride-containing electrolytes and show that chloride desorption, not partial copper monolayer formation, is responsible for the second voltammetric peak.

  9. The New Global Governance Architectures on Grand Challenges and State Capacity

    DEFF Research Database (Denmark)

    Borrás, Susana

    . Aiming to address some specifically identified grand challenges the new governance architectures are creating broader and sustained conditions for problemsolving. But the extent to which they are able to generate the expected transformative change at the domestic level is an empirical question...... that remains open. This paper provides a framework for analyzing that by focusing on three main mediating factors at the domestic level, namely, the knowledge absorptive capacity of domestic actors, their organizational capacity, and their legitimacy as the communicative capacity with which they articulate...

  10. Proposed Grand Challenges in Geoscience Education Research: Articulating a Community Research Agenda

    Science.gov (United States)

    Semken, S. C.; St John, K. K.; Teasdale, R.; Ryker, K.; Riggs, E. M.; Pyle, E. J.; Petcovic, H. L.; McNeal, K.; McDaris, J. R.; Macdonald, H.; Kastens, K.; Cervato, C.

    2017-12-01

    Fourteen ago the Wingspread Project helped establish geoscience education research (GER) as an important research field and highlighted major research questions for GER at the time. More recently, the growth and interest in GER is evident from the increase in geoscience education research articles, the establishment of the NAGT GER Division, the creation of the GER Toolbox, an increase in GER graduate programs, and the growth of tenure-eligible GER faculty positions. As an emerging STEM education research field, the GER community is examining the current state of their research and considering the best course forward so that it can have the greatest collective impact on advancing teaching and learning in the geosciences. As part of an NSF-funded effort to meet this need, 45 researchers drafted priority research questions, or "Grand Challenges", that span 10 geoscience education research themes. These include research on: students' conceptual understanding of the solid and the fluid Earth, K-12 teacher preparation, teaching about Earth in the context of societal problems, access and success of underrepresented groups in the geosciences, spatial and temporal reasoning, quantitative reasoning and use of models, instructional strategies to improve geoscience learning, students' self-regulated learning, and faculty professional development and institutional change. For each theme, several Grand Challenges have been proposed; these have undergone one round of peer-review and are now ready for the AGU community to critically examine the proposed Grand Challenges and make suggestions on strategies for addressing them: http://nagt.org/nagt/geoedresearch/grand_challenges/feedback.html. We seek perspectives from geoscience education researchers, scholars, and reflective educators. It is our vision that the final outcomes of this community-grounded process will be a published guiding framework to (1) focus future GER on questions of high interest to the geoscience education

  11. Avoiding collapse: Grand challenges for science and society to solve by 2050

    Directory of Open Access Journals (Sweden)

    Anthony D. Barnosky

    2016-03-01

    Full Text Available Abstract We maintain that humanity’s grand challenge is solving the intertwined problems of human population growth and overconsumption, climate change, pollution, ecosystem destruction, disease spillovers, and extinction, in order to avoid environmental tipping points that would make human life more difficult and would irrevocably damage planetary life support systems. These are not future issues: for example, detrimental impacts of climate change (increased wildfires and extreme weather, sea-level rise, ocean acidification, pollution (contaminated drinking water in many parts of the world, rapid population growth in some areas (contributing to poverty, war, and increasingly frequent migration and overconsumption in others (a main driver of overexploitation of resources and greenhouse gas emissions, and new disease outbreaks (Ebola, Zika virus already are apparent today, and if trends of the past half century continue, even more damaging, long-lasting impacts would be locked in within three decades. Solving these problems will require some scientific and technological breakthroughs, but that will not be enough. Even more critical will be effective collaboration of environmental and physical scientists with social scientists and those in the humanities, active exchange of information among practitioners in academics, politics, religion, and business and other stakeholders, and clear communication of relevant issues and solutions to the general public. This special feature offers examples of how researchers are addressing this grand challenge through the process of discovering new knowledge and relevant tools, transferring insights across disciplinary boundaries, and establishing critical dialogues with those outside academia to help effect positive global change.

  12. The Grand Challenges of WCRP and the Climate Observing System of the Future

    Science.gov (United States)

    Brasseur, G. P.

    2017-12-01

    The successful implementation the Paris agreement on climate change (COP21) calls for a well-designed global monitoring system of essential climate variables, climate processes and Earth system budgets. The Grand Challenges implemented by the World Climate Research Programme (WCRP) provide an opportunity to investigate issues of high societal relevance, directly related to sea level rise, droughts, floods, extreme heat events, food security, and fresh water availability. These challenges would directly benefit from a well-designed suite of systematic climate observations. Quantification of the evolution of the global energy, water and carbon budgets as well as the development and the production of near-term and regional climate predictions require that a comprehensive, focused, multi-platform observing system (satellites, ground-based and in situ observations) be established in an international context. This system must be accompanied by the development of climate services that should translate and disseminate scientific outcomes as actionable information for users and stakeholders.

  13. A Microbial Perspective on the Grand Challenges in Comparative Animal Physiology

    Science.gov (United States)

    2018-01-01

    ABSTRACT Interactions with microbial communities can have profound influences on animal physiology, thereby impacting animal performance and fitness. Therefore, it is important to understand the diversity and nature of host-microbe interactions in various animal groups (invertebrates, fish, amphibians, reptiles, birds, and mammals). In this perspective, I discuss how the field of host-microbe interactions can be used to address topics that have been identified as grand challenges in comparative animal physiology: (i) horizontal integration of physiological processes across organisms, (ii) vertical integration of physiological processes across organizational levels within organisms, and (iii) temporal integration of physiological processes during evolutionary change. Addressing these challenges will require the use of a variety of animal models and the development of systems approaches that can integrate large, multiomic data sets from both microbial communities and animal hosts. Integrating host-microbe interactions into the established field of comparative physiology represents an exciting frontier for both fields. PMID:29556549

  14. Scientific Grand Challenges: Crosscutting Technologies for Computing at the Exascale - February 2-4, 2010, Washington, D.C.

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, Mohammad A.

    2011-02-06

    The goal of the "Scientific Grand Challenges - Crosscutting Technologies for Computing at the Exascale" workshop in February 2010, jointly sponsored by the U.S. Department of Energy’s Office of Advanced Scientific Computing Research and the National Nuclear Security Administration, was to identify the elements of a research and development agenda that will address these challenges and create a comprehensive exascale computing environment. This exascale computing environment will enable the science applications identified in the eight previously held Scientific Grand Challenges Workshop Series.

  15. Solving the challenges of extended reach well in Brazil; Vencendo desafios em pocos de grande afastamento

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Vicente Abel S.R.; Araujo, Romero G.S.; N Filho, Aluisio F [PETROBRAS, Rio de Janeiro, RJ (Brazil); Veneziani, Luciano S [Halliburton Servicos Ltda., Macae, RJ (Brazil)

    2004-07-01

    With the objective of minimizing costs and allowing oil to be produced from reservoirs near the coast in shallow waters (i.e. less than 3 meters) which make the use of standard marine units impractical, several Extended Reach Wells were drilled from special land based locations in an area with increased environmental awareness (mangroves and 'Salinas'). This was the reality faced in the 'Serra Field' located on the north coast of the state of Rio Grande do Norte (Brasil) and under the management of the Rio Grande do Norte and Ceara Business Unit of PETROBRAS.The ratio between the actual displacement and vertical depth of these wells is approximately 2.7, with actual displacement a bit greater than 2,600 meters, with the idea of reaching displacements exceeding 3,000 meters in the future. In order to drill these wells, special new technologies were adopted; the drilling rig was upgraded, specific software for the development of the project considering both the reservoir and planning of the well, along with the integration and commitment of the Team to follow, execution and that of the service companies resulted in significant improvements in the Drilling Times. Tools adopted in the design of the well, and in the monitoring of the drilling and completion included Torque and Drag Analysis, Rock Mechanics, Drilling Fluids, Well Trajectory, Anti-Collision, Hydraulics and Wellbore Cleaning. This paper will describe the actions taken, the results, challenges and lessons learned during this Exploration Programme in the Serra Field. (author)

  16. 1st oPAC Topical Workshop: Grand Challenges in Accelerator Optimisation

    CERN Document Server

    2013-01-01

    Accelerators are key instruments for fundamental research, health and industry applications. International collaboration is very important for their continued optimisation. To address this oPAC is organising this two-day international workshop on Grand Challenges in Accelerator Optimisation. The workshop will provide an overview of the current state of the art in beam physics, numerical simulations and beam instrumentation and highlight existing limitations. It will discuss research and development being undertaken and ambitions to further improve the performance of existing and future facilities. In addition to invited talks, there will be industry displays and a special seminar covering recent LHC discoveries. All participants will have an opportunity to contribute a poster.

  17. Managing locality in grand challenge applications: a case study of the gyrokinetic toroidal code

    Energy Technology Data Exchange (ETDEWEB)

    Marin, G; Jin, G; Mellor-Crummey, J [Department of Computer Science, Rice University, Houston, TX 77005 (United States)

    2008-07-15

    Achieving high performance with grand challenge applications on today's large-scale parallel systems requires tailoring applications for the characteristics of the modern microprocessor architectures. As part of the US Department of Energy's Scientific Discovery through Advanced Computing (SciDAC) program, we studied and tuned the Gyrokinetic Toroidal Code (GTC), a particle-in-cell code for simulating turbulent transport of particles and energy in burning plasma, developed at Princeton Plasma Physics Laboratory. In this paper, we present a performance study of the application that revealed several opportunities for improving performance by enhancing its data locality. We tuned GTC by performing three kinds of transformations: static data structure reorganization to improve spatial locality, loop nest restructuring for better temporal locality, and dynamic data reordering at run-time to enhance both spatial and temporal reuse. Experimental results show that these changes improve execution time by more than 20% on large parallel systems, including a Cray XT4.

  18. Managing locality in grand challenge applications: a case study of the gyrokinetic toroidal code

    International Nuclear Information System (INIS)

    Marin, G; Jin, G; Mellor-Crummey, J

    2008-01-01

    Achieving high performance with grand challenge applications on today's large-scale parallel systems requires tailoring applications for the characteristics of the modern microprocessor architectures. As part of the US Department of Energy's Scientific Discovery through Advanced Computing (SciDAC) program, we studied and tuned the Gyrokinetic Toroidal Code (GTC), a particle-in-cell code for simulating turbulent transport of particles and energy in burning plasma, developed at Princeton Plasma Physics Laboratory. In this paper, we present a performance study of the application that revealed several opportunities for improving performance by enhancing its data locality. We tuned GTC by performing three kinds of transformations: static data structure reorganization to improve spatial locality, loop nest restructuring for better temporal locality, and dynamic data reordering at run-time to enhance both spatial and temporal reuse. Experimental results show that these changes improve execution time by more than 20% on large parallel systems, including a Cray XT4

  19. Grand Challenges for Biological and Environmental Research: A Long-Term Vision

    Energy Technology Data Exchange (ETDEWEB)

    Arkin, A.; Baliga, N.; Braam, J.; Church, G.; Collins, J; ; Cottingham, R.; Ecker, J.; Gerstein, M.; Gilna, P.; Greenberg, J.; Handelsman, J.; Hubbard, S.; Joachimiak, A.; Liao, J.; Looger, L.; Meyerowitz, E.; Mjolness, E.; Petsko, G.; Sayler, G.; Simpson, M.; Stacey, G.; Sussman, M.; Tiedje, J.; Bader, D.; Cessi, P.; Collins, W.; Denning, S.; Dickinson, R.; Easterling, D.; Edmonds, J.; Feddema, J.; Field, C.; Fridlind, A.; Fung, I.; Held, I.; Jackson, R.; Janetos, A.; Large, W.; Leinen, M.; Leung, R.; Long, S.; Mace, G.; Masiello, C.; Meehl, G.; Ort, D.; Otto-Bliesner, B.; Penner, J.; Prather, M.; Randall, D.; Rasch, P.; Schneider, E.; Shugart, H.; Thornton, P.; Washington, W.; Wildung, R.; Wiscombe, W.; Zak, D.; Zhang, M.; Bielicki, J.; Buford, M.; Cleland, E.; Dale, V.; Duke, C.; Ehleringer, J.; Hecht, A.; Kammen, D.; Marland, G.; Pataki, D.; Riley, M. Robertson, P.; Hubbard, S.

    2010-12-01

    outcomes and behaviors of complex biological and environmental systems, leading to robust solutions for DOE missions and strategic goals. In March 2010, the Biological and Environmental Research Advisory Committee held the Grand Challenges for Biological and Environmental Research: A Long-Term Vision workshop to identify scientific opportunities and grand challenges for BER science in the coming decades and to develop an overall strategy for drafting a long-term vision for BER. Key workshop goals included: (1) Identifying the greatest scientific challenges in biology, climate, and the environment that DOE will face over a 20-year time horizon. (2) Describing how BER should be positioned to address those challenges. (3) Determining the new and innovative tools needed to advance BER science. (4) Suggesting how the workforce of the future should be trained in integrative system science. This report lays out grand research challenges for BER - in biological systems, climate, energy sustainability, computing, and education and workforce training - that can put society on a path to achieve the scientific evidence and predictive understanding needed to inform decision making and planning to address future energy needs, climate change, water availability, and land use.

  20. Network discovery, characterization, and prediction : a grand challenge LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Kegelmeyer, W. Philip, Jr.

    2010-11-01

    This report is the final summation of Sandia's Grand Challenge LDRD project No.119351, 'Network Discovery, Characterization and Prediction' (the 'NGC') which ran from FY08 to FY10. The aim of the NGC, in a nutshell, was to research, develop, and evaluate relevant analysis capabilities that address adversarial networks. Unlike some Grand Challenge efforts, that ambition created cultural subgoals, as well as technical and programmatic ones, as the insistence on 'relevancy' required that the Sandia informatics research communities and the analyst user communities come to appreciate each others needs and capabilities in a very deep and concrete way. The NGC generated a number of technical, programmatic, and cultural advances, detailed in this report. There were new algorithmic insights and research that resulted in fifty-three refereed publications and presentations; this report concludes with an abstract-annotated bibliography pointing to them all. The NGC generated three substantial prototypes that not only achieved their intended goals of testing our algorithmic integration, but which also served as vehicles for customer education and program development. The NGC, as intended, has catalyzed future work in this domain; by the end it had already brought in, in new funding, as much funding as had been invested in it. Finally, the NGC knit together previously disparate research staff and user expertise in a fashion that not only addressed our immediate research goals, but which promises to have created an enduring cultural legacy of mutual understanding, in service of Sandia's national security responsibilities in cybersecurity and counter proliferation.

  1. CDOCKER and lambda λ -dynamics for prospective prediction in D3R Grand Challenge 2

    Science.gov (United States)

    Ding, Xinqiang; Hayes, Ryan L.; Vilseck, Jonah Z.; Charles, Murchtricia K.; Brooks, Charles L.

    2018-01-01

    The opportunity to prospectively predict ligand bound poses and free energies of binding to the Farnesoid X Receptor in the D3R Grand Challenge 2 provided a useful exercise to evaluate CHARMM based docking (CDOCKER) and λ-dynamics methodologies for use in "real-world" applications in computer aided drug design. In addition to measuring their current performance, several recent methodological developments have been analyzed retrospectively to highlight best procedural practices in future applications. For pose prediction with CDOCKER, when the protein structure used for rigid receptor docking was close to the crystallographic holo structure, reliable poses were obtained. Benzimidazoles, with a known holo receptor structure, were successfully docked with an average RMSD of 0.97 Å. Other non-benzimidazole ligands displayed less accuracy largely because the receptor structures we chose for docking were too different from the experimental holo structures. However, retrospective analysis has shown that when these ligands were re-docked into their holo structures, the average RMSD dropped to 1.18 Å for all ligands. When sulfonamides and spiros were docked with the apo structure, which agrees more with their holo structure than the structures we chose, five out of six ligands were correctly docked. These docking results emphasize the need for flexible receptor docking approaches. For λ-dynamics techniques, including multisite λ-dynamics (MSλD), reasonable agreement with experiment was observed for the 33 ligands investigated; root mean square errors of 2.08 and 1.67 kcal/mol were obtained for free energy sets 1 and 2, respectively. Retrospectively, soft-core potentials, adaptive landscape flattening, and biasing potential replica exchange (BP-REX) algorithms were critical to model large substituent perturbations with sufficient precision and within restrictive timeframes, such as was required with participation in Grand Challenge 2. These developments, their

  2. Development of a Multi-functional Soft Robot (SNUMAX and Performance in RoboSoft Grand Challenge

    Directory of Open Access Journals (Sweden)

    Jun-Young Lee

    2016-10-01

    Full Text Available This paper introduces SNUMAX, the grand winner of the RoboSoft Grand Challenge. SNUMAX was built to complete all the tasks of the challenge. Completing these tasks required robotic compliant components that could adapt to variable situations and environments and generate enough stiffness to maintain performance. SNUMAX has three key components: transformable origami wheels, a polymer-based variable stiffness manipulator, and an adaptive caging gripper. This paper describes the design of these components and how they worked together to allow the robot to perform the contest’s navigation and manipulation tasks.

  3. Team science and the physician-scientist in the age of grand health challenges.

    Science.gov (United States)

    Steer, Clifford J; Jackson, Peter R; Hornbeak, Hortencia; McKay, Catherine K; Sriramarao, P; Murtaugh, Michael P

    2017-09-01

    Despite remarkable advances in medical research, clinicians face daunting challenges from new diseases, variations in patient responses to interventions, and increasing numbers of people with chronic health problems. The gap between biomedical research and unmet clinical needs can be addressed by highly talented interdisciplinary investigators focused on translational bench-to-bedside medicine. The training of talented physician-scientists comfortable with forming and participating in multidisciplinary teams that address complex health problems is a top national priority. Challenges, methods, and experiences associated with physician-scientist training and team building were explored at a workshop held at the Second International Conference on One Medicine One Science (iCOMOS 2016), April 24-27, 2016, in Minneapolis, Minnesota. A broad range of scientists, regulatory authorities, and health care experts determined that critical investments in interdisciplinary training are essential for the future of medicine and healthcare delivery. Physician-scientists trained in a broad, nonlinear, cross-disciplinary manner are and will be essential members of science teams in the new age of grand health challenges and the birth of precision medicine. Team science approaches have accomplished biomedical breakthroughs once considered impossible, and dedicated physician-scientists have been critical to these achievements. Together, they translate into the pillars of academic growth and success. © 2017 New York Academy of Sciences.

  4. Grand Canonical adaptive resolution simulation for molecules with electrons: A theoretical framework based on physical consistency

    Science.gov (United States)

    Delle Site, Luigi

    2018-01-01

    A theoretical scheme for the treatment of an open molecular system with electrons and nuclei is proposed. The idea is based on the Grand Canonical description of a quantum region embedded in a classical reservoir of molecules. Electronic properties of the quantum region are calculated at constant electronic chemical potential equal to that of the corresponding (large) bulk system treated at full quantum level. Instead, the exchange of molecules between the quantum region and the classical environment occurs at the chemical potential of the macroscopic thermodynamic conditions. The Grand Canonical Adaptive Resolution Scheme is proposed for the treatment of the classical environment; such an approach can treat the exchange of molecules according to first principles of statistical mechanics and thermodynamic. The overall scheme is build on the basis of physical consistency, with the corresponding definition of numerical criteria of control of the approximations implied by the coupling. Given the wide range of expertise required, this work has the intention of providing guiding principles for the construction of a well founded computational protocol for actual multiscale simulations from the electronic to the mesoscopic scale.

  5. Solving the challenges of extended reach well in Brazil; Vencendo desafios em pocos de grande afastamento

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Vicente Abel S.R.; Araujo, Romero G.S.; N. Filho, Aluisio F. [PETROBRAS, Rio de Janeiro, RJ (Brazil); Veneziani, Luciano S. [Halliburton Servicos Ltda., Macae, RJ (Brazil)

    2004-07-01

    With the objective of minimizing costs and allowing oil to be produced from reservoirs near the coast in shallow waters (i.e. less than 3 meters) which make the use of standard marine units impractical, several Extended Reach Wells were drilled from special land based locations in an area with increased environmental awareness (mangroves and 'Salinas'). This was the reality faced in the 'Serra Field' located on the north coast of the state of Rio Grande do Norte (Brasil) and under the management of the Rio Grande do Norte and Ceara Business Unit of PETROBRAS.The ratio between the actual displacement and vertical depth of these wells is approximately 2.7, with actual displacement a bit greater than 2,600 meters, with the idea of reaching displacements exceeding 3,000 meters in the future. In order to drill these wells, special new technologies were adopted; the drilling rig was upgraded, specific software for the development of the project considering both the reservoir and planning of the well, along with the integration and commitment of the Team to follow, execution and that of the service companies resulted in significant improvements in the Drilling Times. Tools adopted in the design of the well, and in the monitoring of the drilling and completion included Torque and Drag Analysis, Rock Mechanics, Drilling Fluids, Well Trajectory, Anti-Collision, Hydraulics and Wellbore Cleaning. This paper will describe the actions taken, the results, challenges and lessons learned during this Exploration Programme in the Serra Field. (author)

  6. Addressing China's grand challenge of achieving food security while ensuring environmental sustainability.

    Science.gov (United States)

    Lu, Yonglong; Jenkins, Alan; Ferrier, Robert C; Bailey, Mark; Gordon, Iain J; Song, Shuai; Huang, Jikun; Jia, Shaofeng; Zhang, Fusuo; Liu, Xuejun; Feng, Zhaozhong; Zhang, Zhibin

    2015-02-01

    China's increasingly urbanized and wealthy population is driving a growing and changing demand for food, which might not be met without significant increase in agricultural productivity and sustainable use of natural resources. Given the past relationship between lack of access to affordable food and political instability, food security has to be given a high priority on national political agendas in the context of globalization. The drive for increased food production has had a significant impact on the environment, and the deterioration in ecosystem quality due to historic and current levels of pollution will potentially compromise the food production system in China. We discuss the grand challenges of not only producing more food but also producing it sustainably and without environmental degradation. In addressing these challenges, food production should be considered as part of an environmental system (soil, air, water, and biodiversity) and not independent from it. It is imperative that new ways of meeting the demand for food are developed while safeguarding the natural resources upon which food production is based. We present a holistic approach to both science and policy to ensure future food security while embracing the ambition of achieving environmental sustainability in China. It is a unique opportunity for China to be a role model as a new global player, especially for other emerging economies.

  7. New capabilities in the HENP grand challenge storage access system and its application at RHIC

    International Nuclear Information System (INIS)

    Bernardo, L.; Gibbard, B.; Malon, D.; Nordberg, H.; Olson, D.; Porter, R.; Shoshani, A.; Sim, A.; Vaniachine, A.; Wenaus, T.; Wu, K.; Zimmerman, D.

    2000-01-01

    The High Energy and Nuclear Physics Data Access Grand Challenge project has developed an optimizing storage access software system that was prototyped at RHIC. It is currently undergoing integration with the STAR experiment in preparation for data taking that starts in mid-2000. The behavior and lessons learned in the RHIC Mock Data Challenge exercises are described as well as the observed performance under conditions designed to characterize scalability. Up to 250 simultaneous queries were tested and up to 10 million events across 7 event components were involved in these queries. The system coordinates the staging of ''bundles'' of files from the HPSS tape system, so that all the needed components of each event are in disk cache when accessed by the application software. The caching policy algorithm for the coordinated bundle staging is described in the paper. The initial prototype implementation interfaced to the Objectivity/DB. In this latest version, it evolved to work with arbitrary files and use CORBA interfaces to the tag database and file catalog services. The interface to the tag database and the MySQL-based file catalog services used by STAR are described along with the planned usage scenarios

  8. Groundwater Challenges of the Lower Rio Grande: A Case Study of Legal Issues in Texas and New Mexico

    Directory of Open Access Journals (Sweden)

    Elizabeth Wheat

    2015-03-01

    Full Text Available In 1938, Texas, New Mexico, and Colorado signed the Rio Grande Compact, establishing terms of apportionment for some of the water from the Rio Grande for the three states. Following congressional approval in 1939, this compact governs water allocation in a region with a variable climate and frequent drought conditions and established the Rio Grande Compact Commission, comprised of a commissioner from each state and one from the federal government, to enforce the compact. With an increasing population and declining surface water supply, the Compact has been tested among the parties and within the states themselves. In a case currently before the U.S. Supreme Court, Texas v. New Mexico and Colorado (2013, Texas claims New Mexico is violating the Compact and Rio Grande Project Act by using water in excess of its apportionment through its allowance of diversions of surface and groundwater. The issue is further compounded by disputes within Texas over separate legal regimes for groundwater and surface water. Combined with growing scarcity issues, the allocation of water in the Lower Rio Grande presents a timely natural resource challenge. This review explores legal issues involved in the case as well as growing challenges of population growth, agricultural development needs, and water shortages.

  9. The Grand Challenge of Basin-Scale Groundwater Quality Management Modelling

    Science.gov (United States)

    Fogg, G. E.

    2017-12-01

    The last 50+ years of agricultural, urban and industrial land and water use practices have accelerated the degradation of groundwater quality in the upper portions of many major aquifer systems upon which much of the world relies for water supply. In the deepest and most extensive systems (e.g., sedimentary basins) that typically have the largest groundwater production rates and hold fresh groundwaters on decadal to millennial time scales, most of the groundwater is not yet contaminated. Predicting the long-term future groundwater quality in such basins is a grand scientific challenge. Moreover, determining what changes in land and water use practices would avert future, irreversible degradation of these massive freshwater stores is a grand challenge both scientifically and societally. It is naïve to think that the problem can be solved by eliminating or reducing enough of the contaminant sources, for human exploitation of land and water resources will likely always result in some contamination. The key lies in both reducing the contaminant sources and more proactively managing recharge in terms of both quantity and quality, such that the net influx of contaminants is sufficiently moderate and appropriately distributed in space and time to reverse ongoing groundwater quality degradation. Just as sustainable groundwater quantity management is greatly facilitated with groundwater flow management models, sustainable groundwater quality management will require the use of groundwater quality management models. This is a new genre of hydrologic models do not yet exist, partly because of the lack of modeling tools and the supporting research to model non-reactive as well as reactive transport on large space and time scales. It is essential that the contaminant hydrogeology community, which has heretofore focused almost entirely on point-source plume-scale problems, direct it's efforts toward the development of process-based transport modeling tools and analyses capable

  10. On the added value of forensic science and grand innovation challenges for the forensic community.

    Science.gov (United States)

    van Asten, Arian C

    2014-03-01

    In this paper the insights and results are presented of a long term and ongoing improvement effort within the Netherlands Forensic Institute (NFI) to establish a valuable innovation programme. From the overall perspective of the role and use of forensic science in the criminal justice system, the concepts of Forensic Information Value Added (FIVA) and Forensic Information Value Efficiency (FIVE) are introduced. From these concepts the key factors determining the added value of forensic investigations are discussed; Evidential Value, Relevance, Quality, Speed and Cost. By unravelling the added value of forensic science and combining this with the future needs and scientific and technological developments, six forensic grand challenges are introduced: i) Molecular Photo-fitting; ii) chemical imaging, profiling and age estimation of finger marks; iii) Advancing Forensic Medicine; iv) Objective Forensic Evaluation; v) the Digital Forensic Service Centre and vi) Real time In-Situ Chemical Identification. Finally, models for forensic innovation are presented that could lead to major international breakthroughs on all these six themes within a five year time span. This could cause a step change in the added value of forensic science and would make forensic investigative methods even more valuable than they already are today. © 2013. Published by Elsevier Ireland Ltd on behalf of Forensic Science Society. All rights reserved.

  11. Hyperresolution global land surface modeling: Meeting a grand challenge for monitoring Earth's terrestrial water

    Science.gov (United States)

    Wood, Eric F.; Roundy, Joshua K.; Troy, Tara J.; van Beek, L. P. H.; Bierkens, Marc F. P.; Blyth, Eleanor; de Roo, Ad; DöLl, Petra; Ek, Mike; Famiglietti, James; Gochis, David; van de Giesen, Nick; Houser, Paul; Jaffé, Peter R.; Kollet, Stefan; Lehner, Bernhard; Lettenmaier, Dennis P.; Peters-Lidard, Christa; Sivapalan, Murugesu; Sheffield, Justin; Wade, Andrew; Whitehead, Paul

    2011-05-01

    Monitoring Earth's terrestrial water conditions is critically important to many hydrological applications such as global food production; assessing water resources sustainability; and flood, drought, and climate change prediction. These needs have motivated the development of pilot monitoring and prediction systems for terrestrial hydrologic and vegetative states, but to date only at the rather coarse spatial resolutions (˜10-100 km) over continental to global domains. Adequately addressing critical water cycle science questions and applications requires systems that are implemented globally at much higher resolutions, on the order of 1 km, resolutions referred to as hyperresolution in the context of global land surface models. This opinion paper sets forth the needs and benefits for a system that would monitor and predict the Earth's terrestrial water, energy, and biogeochemical cycles. We discuss six major challenges in developing a system: improved representation of surface-subsurface interactions due to fine-scale topography and vegetation; improved representation of land-atmospheric interactions and resulting spatial information on soil moisture and evapotranspiration; inclusion of water quality as part of the biogeochemical cycle; representation of human impacts from water management; utilizing massively parallel computer systems and recent computational advances in solving hyperresolution models that will have up to 109 unknowns; and developing the required in situ and remote sensing global data sets. We deem the development of a global hyperresolution model for monitoring the terrestrial water, energy, and biogeochemical cycles a "grand challenge" to the community, and we call upon the international hydrologic community and the hydrological science support infrastructure to endorse the effort.

  12. Grand challenges in understanding the interplay of climate and land changes

    Science.gov (United States)

    Liu, Shuguang; Bond-Lamberty, Ben; Boysen, Lena R.; Ford, James D.; Fox, Andrew; Gallo, Kevin; Hatfield, Jerry L.; Henebry, Geoffrey M.; Huntington, Thomas G.; Liu, Zhihua; Loveland, Thomas R.; Norby, Richard J.; Sohl, Terry L.; Steiner, Allison L.; Yuan, Wenping; Zhang, Zhao; Zhao, Shuqing

    2017-01-01

    Half of Earth’s land surface has been altered by human activities, creating various consequences on the climate and weather systems at local to global scales, which in turn affect a myriad of land surface processes and the adaptation behaviors. This study reviews the status and major knowledge gaps in the interactions of land and atmospheric changes and present 11 grand challenge areas for the scientific research and adaptation community in the coming decade. These land-cover and land-use change (LCLUC)-related areas include 1) impacts on weather and climate, 2) carbon and other biogeochemical cycles, 3) biospheric emissions, 4) the water cycle, 5) agriculture, 6) urbanization, 7) acclimation of biogeochemical processes to climate change, 8) plant migration, 9) land-use projections, 10) model and data uncertainties, and, finally, 11) adaptation strategies. Numerous studies have demonstrated the effects of LCLUC on local to global climate and weather systems, but these putative effects vary greatly in magnitude and even sign across space, time, and scale and thus remain highly uncertain. At the same time, many challenges exist toward improved understanding of the consequences of atmospheric and climate change on land process dynamics and services. Future effort must improve the understanding of the scale-dependent, multifaceted perturbations and feedbacks between land and climate changes in both reality and models. To this end, one critical cross-disciplinary need is to systematically quantify and better understand measurement and model uncertainties. Finally, LCLUC mitigation and adaptation assessments must be strengthened to identify implementation barriers, evaluate and prioritize opportunities, and examine how decision-making processes work in specific contexts.

  13. Hyperresolution Global Land Surface Modeling: Meeting a Grand Challenge for Monitoring Earth's Terrestrial Water

    Science.gov (United States)

    Wood, Eric F.; Roundy, Joshua K.; Troy, Tara J.; van Beek, L. P. H.; Bierkens, Marc F. P.; 4 Blyth, Eleanor; de Roo, Ad; Doell. Petra; Ek, Mike; Famiglietti, James; hide

    2011-01-01

    Monitoring Earth's terrestrial water conditions is critically important to many hydrological applications such as global food production; assessing water resources sustainability; and flood, drought, and climate change prediction. These needs have motivated the development of pilot monitoring and prediction systems for terrestrial hydrologic and vegetative states, but to date only at the rather coarse spatial resolutions (approx.10-100 km) over continental to global domains. Adequately addressing critical water cycle science questions and applications requires systems that are implemented globally at much higher resolutions, on the order of 1 km, resolutions referred to as hyperresolution in the context of global land surface models. This opinion paper sets forth the needs and benefits for a system that would monitor and predict the Earth's terrestrial water, energy, and biogeochemical cycles. We discuss six major challenges in developing a system: improved representation of surface-subsurface interactions due to fine-scale topography and vegetation; improved representation of land-atmospheric interactions and resulting spatial information on soil moisture and evapotranspiration; inclusion of water quality as part of the biogeochemical cycle; representation of human impacts from water management; utilizing massively parallel computer systems and recent computational advances in solving hyperresolution models that will have up to 10(exp 9) unknowns; and developing the required in situ and remote sensing global data sets. We deem the development of a global hyperresolution model for monitoring the terrestrial water, energy, and biogeochemical cycles a grand challenge to the community, and we call upon the international hydrologic community and the hydrological science support infrastructure to endorse the effort.

  14. Challenges and roles in electronic data publication

    Science.gov (United States)

    Ocvirk, Pierre; Genova, Francoise

    2015-08-01

    The promise of electronic astronomical data publication is to allow the discovery and reusability of all relevant data for a given object, model, or region of the sky. The CDS has been a major actor in making this promise come true through its flagship services: SIMBAD, VizieR, Aladin and the definition of astronomical data and metadata standards. The challenges are many: electronic data publication still suffers from relic practices of the paper era and volumes keep increasing. In this framework, guaranteeing the relevance and quality of the data and access requires teams of librarians, engineers and astronomers to work together, as well as continuous collaboration with the major data producers and journals and constant technological innovation. The publication workflow at CDS illustrates the fundamental, necessary interplay and responsibilities of the various actors (data producer, journal, data center) in the current, evolving astronomical publication landscape.

  15. Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration.

    Science.gov (United States)

    Brunner, Dani; Balcı, Fuat; Ludvig, Elliot A

    2012-02-01

    Drug discovery for brain disorders is undergoing a period of upheaval. Faced with an empty drug pipeline and numerous failures of potential new drugs in clinical trials, many large pharmaceutical companies have been shrinking or even closing down their research divisions that focus on central nervous system (CNS) disorders. In this paper, we argue that many of the difficulties facing CNS drug discovery stem from a lack of robustness in pre-clinical (i.e., non-human animal) testing. There are two main sources for this lack of robustness. First, there is the lack of replicability of many results from the pre-clinical stage, which we argue is driven by a combination of publication bias and inappropriate selection of statistical and experimental designs. Second, there is the frequent failure to translate results in non-human animals to parallel results in humans in the clinic. This limitation can only be overcome by developing new behavioral tests for non-human animals that have predictive, construct, and etiological validity. Here, we present these translational difficulties as a "grand challenge" to researchers from comparative cognition, who are well positioned to provide new methods for testing behavior and cognition in non-human animals. These new experimental protocols will need to be both statistically robust and target behavioral and cognitive processes that allow for better connection with human CNS disorders. Our hope is that this downturn in industrial research may represent an opportunity to develop new protocols that will re-kindle the search for more effective and safer drugs for CNS disorders. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. Permeable Binaries, Societal Grand Challenges, and the Roles of the Twenty-first-century Archival and Recordkeeping Profession

    OpenAIRE

    Gilliland, AJ

    2015-01-01

    Building upon recent work, this paper demonstrates how 21st century recordkeeping concerns are integral to societal grand challenges that have been identified by governments, think tanks, scholarly organisations and affected communities around the globe. Using the example of forced displacement and migration the paper focuses on ways in which recordkeeping is inextricably linked to both the causes and possible digital, policy and educational mechanisms for addressing certain aspects of societ...

  17. Thermal Protection for Mars Sample Return Earth Entry Vehicle: A Grand Challenge for Design Methodology and Reliability Verification

    Science.gov (United States)

    Venkatapathy, Ethiraj; Gage, Peter; Wright, Michael J.

    2017-01-01

    Mars Sample Return is our Grand Challenge for the coming decade. TPS (Thermal Protection System) nominal performance is not the key challenge. The main difficulty for designers is the need to verify unprecedented reliability for the entry system: current guidelines for prevention of backward contamination require that the probability of spores larger than 1 micron diameter escaping into the Earth environment be lower than 1 million for the entire system, and the allocation to TPS would be more stringent than that. For reference, the reliability allocation for Orion TPS is closer to 11000, and the demonstrated reliability for previous human Earth return systems was closer to 1100. Improving reliability by more than 3 orders of magnitude is a grand challenge indeed. The TPS community must embrace the possibility of new architectures that are focused on reliability above thermal performance and mass efficiency. MSR (Mars Sample Return) EEV (Earth Entry Vehicle) will be hit with MMOD (Micrometeoroid and Orbital Debris) prior to reentry. A chute-less aero-shell design which allows for self-righting shape was baselined in prior MSR studies, with the assumption that a passive system will maximize EEV robustness. Hence the aero-shell along with the TPS has to take ground impact and not break apart. System verification will require testing to establish ablative performance and thermal failure but also testing of damage from MMOD, and structural performance at ground impact. Mission requirements will demand analysis, testing and verification that are focused on establishing reliability of the design. In this proposed talk, we will focus on the grand challenge of MSR EEV TPS and the need for innovative approaches to address challenges in modeling, testing, manufacturing and verification.

  18. D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies

    Science.gov (United States)

    Gaieb, Zied; Liu, Shuai; Gathiaka, Symon; Chiu, Michael; Yang, Huanwang; Shao, Chenghua; Feher, Victoria A.; Walters, W. Patrick; Kuhn, Bernd; Rudolph, Markus G.; Burley, Stephen K.; Gilson, Michael K.; Amaro, Rommie E.

    2018-01-01

    The Drug Design Data Resource (D3R) ran Grand Challenge 2 (GC2) from September 2016 through February 2017. This challenge was based on a dataset of structures and affinities for the nuclear receptor farnesoid X receptor (FXR), contributed by F. Hoffmann-La Roche. The dataset contained 102 IC50 values, spanning six orders of magnitude, and 36 high-resolution co-crystal structures with representatives of four major ligand classes. Strong global participation was evident, with 49 participants submitting 262 prediction submission packages in total. Procedurally, GC2 mimicked Grand Challenge 2015 (GC2015), with a Stage 1 subchallenge testing ligand pose prediction methods and ranking and scoring methods, and a Stage 2 subchallenge testing only ligand ranking and scoring methods after the release of all blinded co-crystal structures. Two smaller curated sets of 18 and 15 ligands were developed to test alchemical free energy methods. This overview summarizes all aspects of GC2, including the dataset details, challenge procedures, and participant results. We also consider implications for progress in the field, while highlighting methodological areas that merit continued development. Similar to GC2015, the outcome of GC2 underscores the pressing need for methods development in pose prediction, particularly for ligand scaffolds not currently represented in the Protein Data Bank (http://www.pdb.org), and in affinity ranking and scoring of bound ligands.

  19. Grand Challenges of Advanced Computing for Energy Innovation Report from the Workshop Held July 31-August 2, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Larzelere, Alex R.; Ashby, Steven F.; Christensen, Dana C.; Crawford, Dona L.; Khaleel, Mohammad A.; John, Grosh; Stults, B. Ray; Lee, Steven L.; Hammond, Steven W.; Grover, Benjamin T.; Neely, Rob; Dudney, Lee Ann; Goldstein, Noah C.; Wells, Jack; Peltz, Jim

    2013-03-06

    On July 31-August 2 of 2012, the U.S. Department of Energy (DOE) held a workshop entitled Grand Challenges of Advanced Computing for Energy Innovation. This workshop built on three earlier workshops that clearly identified the potential for the Department and its national laboratories to enable energy innovation. The specific goal of the workshop was to identify the key challenges that the nation must overcome to apply the full benefit of taxpayer-funded advanced computing technologies to U.S. energy innovation in the ways that the country produces, moves, stores, and uses energy. Perhaps more importantly, the workshop also developed a set of recommendations to help the Department overcome those challenges. These recommendations provide an action plan for what the Department can do in the coming years to improve the nation’s energy future.

  20. The Gap Frame - Enriching the SDG Compass by translating the SDGs into relevant national Grand Challenges for strategic business opportunities

    OpenAIRE

    Muff, Katrin; Kapalka, Agnieszka; Dyllick, Thomas

    2017-01-01

    The global agenda of Grand Challenges until 2030 is set: the Sustainable Development Goals (SDGs) enjoy broad global governmental acceptance and increasing business awareness. This paper takes a concrete look at how we can reach a state-of-the-world by 2030 that is ‘safe for all of us’. Getting there requires relevant national measures that are easily accessible for business, which is considered a key transformative force with its innovation power. The global nature and focus of the SDGs make...

  1. Next-Generation Photon Sources for Grand Challenges in Science and Energy

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    report identifies two aspects of energy science in which next-generation ultraviolet and X-ray light sources will have the deepest and broadest impact: (1) The temporal evolution of electrons, spins, atoms, and chemical reactions, down to the femtosecond time scale. (2) Spectroscopic and structural imaging of nano objects (or nanoscale regions of inhomogeneous materials) with nanometer spatial resolution and ultimate spectral resolution. The dual advances of temporal and spatial resolution promised by fourth-generation light sources ideally match the challenges of control science. Femtosecond time resolution has opened completely new territory where atomic motion can be followed in real time and electronic excitations and decay processes can be followed over time. Coherent imaging with short-wavelength radiation will make it possible to access the nanometer length scale, where intrinsic quantum behavior becomes dominant. Performing spectroscopy on individual nanometer-scale objects rather than on conglomerates will eliminate the blurring of the energy levels induced by particle size and shape distributions and reveal the energetics of single functional units. Energy resolution limited only by the uncertainty relation is enabled by these advances. Current storage-ring-based light sources and their incremental enhancements cannot meet the need for femtosecond time resolution, nanometer spatial resolution, intrinsic energy resolution, full coherence over energy ranges up to hard X-rays, and peak brilliance required to enable the new science outlined in this report. In fact, the new, unexplored territory is so expansive that no single currently imagined light source technology can fulfill the whole potential. Both technological and economic challenges require resolution as we move forward. For example, femtosecond time resolution and high peak brilliance are required for following chemical reactions in real time, but lower peak brilliance and high repetition rate are needed

  2. Electronic Information – Threat or Challenge to Librarians and ...

    African Journals Online (AJOL)

    Electronic Information – Threat or Challenge to Librarians and Library Buildings. ... electronic resources because as new things and methods emerge, they exist ... that world trends in the paper industry and Internet use do not justify the fears ...

  3. Evaluation and comparison of current fetal ultrasound image segmentation methods for biometric measurements: a grand challenge.

    Science.gov (United States)

    Rueda, Sylvia; Fathima, Sana; Knight, Caroline L; Yaqub, Mohammad; Papageorghiou, Aris T; Rahmatullah, Bahbibi; Foi, Alessandro; Maggioni, Matteo; Pepe, Antonietta; Tohka, Jussi; Stebbing, Richard V; McManigle, John E; Ciurte, Anca; Bresson, Xavier; Cuadra, Meritxell Bach; Sun, Changming; Ponomarev, Gennady V; Gelfand, Mikhail S; Kazanov, Marat D; Wang, Ching-Wei; Chen, Hsiang-Chou; Peng, Chun-Wei; Hung, Chu-Mei; Noble, J Alison

    2014-04-01

    This paper presents the evaluation results of the methods submitted to Challenge US: Biometric Measurements from Fetal Ultrasound Images, a segmentation challenge held at the IEEE International Symposium on Biomedical Imaging 2012. The challenge was set to compare and evaluate current fetal ultrasound image segmentation methods. It consisted of automatically segmenting fetal anatomical structures to measure standard obstetric biometric parameters, from 2D fetal ultrasound images taken on fetuses at different gestational ages (21 weeks, 28 weeks, and 33 weeks) and with varying image quality to reflect data encountered in real clinical environments. Four independent sub-challenges were proposed, according to the objects of interest measured in clinical practice: abdomen, head, femur, and whole fetus. Five teams participated in the head sub-challenge and two teams in the femur sub-challenge, including one team who tackled both. Nobody attempted the abdomen and whole fetus sub-challenges. The challenge goals were two-fold and the participants were asked to submit the segmentation results as well as the measurements derived from the segmented objects. Extensive quantitative (region-based, distance-based, and Bland-Altman measurements) and qualitative evaluation was performed to compare the results from a representative selection of current methods submitted to the challenge. Several experts (three for the head sub-challenge and two for the femur sub-challenge), with different degrees of expertise, manually delineated the objects of interest to define the ground truth used within the evaluation framework. For the head sub-challenge, several groups produced results that could be potentially used in clinical settings, with comparable performance to manual delineations. The femur sub-challenge had inferior performance to the head sub-challenge due to the fact that it is a harder segmentation problem and that the techniques presented relied more on the femur's appearance.

  4. CHALLENGES OF ELECTRONIC INFORMATION RESOURCES IN ...

    African Journals Online (AJOL)

    This paper discusses the role of policy for proper and efficient library services in the electronic era. It points out some of the possible dangers of embarking in electronic resources without a proper focus at hand. Thus, it calls for today's librarians and policy makers to brainstorm and come up with working policies suitable to ...

  5. A Case Study in Competitive Technical and Market Intelligence Support and Lessons Learned for the uChemLab LDRD Grand Challenge Project; TOPICAL

    International Nuclear Information System (INIS)

    SOUTHWELL, EDWIN T.; GARCIA, MARIE L.; MEYERS, CHARLES E.

    2001-01-01

    The(mu)ChemLab(trademark) Laboratory Directed Research and Development (LDRD) Grand Challenge project began in October 1996 and ended in September 2000. The technical managers of the(mu)ChemLab(trademark) project and the LDRD office, with the support of a consultant, conducted a competitive technical and market demand intelligence analysis of the(mu)ChemLab(trademark). The managers used this knowledge to make project decisions and course adjustments. CTI/MDI positively impacted the project's technology development, uncovered potential technology partnerships, and supported eventual industry partner contacts. CTI/MDI analysis is now seen as due diligence and the(mu)ChemLab(trademark) project is now the model for other Sandia LDRD Grand Challenge undertakings. This document describes the CTI/MDI analysis and captures the more important ''lessons learned'' of this Grand Challenge project, as reported by the project's management team

  6. Opportunities and challenges in electronic publication

    Czech Academy of Sciences Publication Activity Database

    Rákosník, Jiří; Teschke, O.

    2014-01-01

    Roč. 93, September (2014), s. 3-5 ISSN 1027-488X Institutional support: RVO:67985840 Keywords : electronic publishing * mathematical scholarly literature * archiving http://www.ems-ph.org/journals/newsletter/pdf/2014-09-93.pdf

  7. Lessons learned in induced fit docking and metadynamics in the Drug Design Data Resource Grand Challenge 2

    Science.gov (United States)

    Baumgartner, Matthew P.; Evans, David A.

    2018-01-01

    Two of the major ongoing challenges in computational drug discovery are predicting the binding pose and affinity of a compound to a protein. The Drug Design Data Resource Grand Challenge 2 was developed to address these problems and to drive development of new methods. The challenge provided the 2D structures of compounds for which the organizers help blinded data in the form of 35 X-ray crystal structures and 102 binding affinity measurements and challenged participants to predict the binding pose and affinity of the compounds. We tested a number of pose prediction methods as part of the challenge; we found that docking methods that incorporate protein flexibility (Induced Fit Docking) outperformed methods that treated the protein as rigid. We also found that using binding pose metadynamics, a molecular dynamics based method, to score docked poses provided the best predictions of our methods with an average RMSD of 2.01 Å. We tested both structure-based (e.g. docking) and ligand-based methods (e.g. QSAR) in the affinity prediction portion of the competition. We found that our structure-based methods based on docking with Smina (Spearman ρ = 0.614), performed slightly better than our ligand-based methods (ρ = 0.543), and had equivalent performance with the other top methods in the competition. Despite the overall good performance of our methods in comparison to other participants in the challenge, there exists significant room for improvement especially in cases such as these where protein flexibility plays such a large role.

  8. Governance Challenges in Joint Inter-Jurisdictional Management: The Grand Teton National Park, Wyoming, Elk Case

    Science.gov (United States)

    Clark, Susan G.; Vernon, Marian E.

    2015-08-01

    The controversial elk reduction program (elk hunt) in Grand Teton National Park, WY, has been a source of conflict since it was legislated in 1950. The hunt is jointly managed by the National Park Service and the Wyoming Game and Fish Department. This forced organizational partnership and the conflicting mandates of these two agencies have led to persistent conflict that seems irresolvable under the current decision-making process. To better understand the decision-making process and participant perspectives, we reviewed management documents, technical literature, and newspaper articles, and interviewed 35 key participants in this case. We used these data to analyze and appraise the adequacy of the decision-making process for the park elk hunt and to ask whether it reflects the common interest. We found deficiencies in all functions of the decision-making process. Neither the decisions made nor the process itself include diverse perspectives, nor do they attend to valid and appropriate participant concerns. Agency officials focus their attention on technical rather than procedural concerns, which largely obfuscates the underlying tension in the joint inter-jurisdictional management arrangement and ultimately contributes to the hunt's annual implementation to the detriment of the common interest. We offer specific yet widely applicable recommendations to better approximate an inclusive and democratic decision-making process that serves the community's common interests.

  9. Meeting the Challenge of Electronic Communication

    Science.gov (United States)

    Holm, Jeanne; Panda, Peggy; Hawley, Christopher

    1997-01-01

    The Jet Propulsion Laboraytory (JPL), Californian Institute of Technology, is challenged with no only providing an environment where engineers and scientists can exchange informaiton quickly and accurately, but also providing the public with the fruits of its exploration in a way that is both interesting and understandable to all age groups and professional arenas.

  10. Relative binding affinity prediction of farnesoid X receptor in the D3R Grand Challenge 2 using FEP+

    Science.gov (United States)

    Schindler, Christina; Rippmann, Friedrich; Kuhn, Daniel

    2018-01-01

    Physics-based free energy simulations have increasingly become an important tool for predicting binding affinity and the recent introduction of automated protocols has also paved the way towards a more widespread use in the pharmaceutical industry. The D3R 2016 Grand Challenge 2 provided an opportunity to blindly test the commercial free energy calculation protocol FEP+ and assess its performance relative to other affinity prediction methods. The present D3R free energy prediction challenge was built around two experimental data sets involving inhibitors of farnesoid X receptor (FXR) which is a promising anticancer drug target. The FXR binding site is predominantly hydrophobic with few conserved interaction motifs and strong induced fit effects making it a challenging target for molecular modeling and drug design. For both data sets, we achieved reasonable prediction accuracy (RMSD ≈ 1.4 kcal/mol, rank 3-4 according to RMSD out of 20 submissions) comparable to that of state-of-the-art methods in the field. Our D3R results boosted our confidence in the method and strengthen our desire to expand its applications in future in-house drug design projects.

  11. Relative binding affinity prediction of farnesoid X receptor in the D3R Grand Challenge 2 using FEP.

    Science.gov (United States)

    Schindler, Christina; Rippmann, Friedrich; Kuhn, Daniel

    2018-01-01

    Physics-based free energy simulations have increasingly become an important tool for predicting binding affinity and the recent introduction of automated protocols has also paved the way towards a more widespread use in the pharmaceutical industry. The D3R 2016 Grand Challenge 2 provided an opportunity to blindly test the commercial free energy calculation protocol FEP+ and assess its performance relative to other affinity prediction methods. The present D3R free energy prediction challenge was built around two experimental data sets involving inhibitors of farnesoid X receptor (FXR) which is a promising anticancer drug target. The FXR binding site is predominantly hydrophobic with few conserved interaction motifs and strong induced fit effects making it a challenging target for molecular modeling and drug design. For both data sets, we achieved reasonable prediction accuracy (RMSD ≈ 1.4 kcal/mol, rank 3-4 according to RMSD out of 20 submissions) comparable to that of state-of-the-art methods in the field. Our D3R results boosted our confidence in the method and strengthen our desire to expand its applications in future in-house drug design projects.

  12. Scientific Grand Challenges: Challenges in Climate Change Science and the Role of Computing at the Extreme Scale

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, Mohammad A.; Johnson, Gary M.; Washington, Warren M.

    2009-07-02

    The U.S. Department of Energy (DOE) Office of Biological and Environmental Research (BER) in partnership with the Office of Advanced Scientific Computing Research (ASCR) held a workshop on the challenges in climate change science and the role of computing at the extreme scale, November 6-7, 2008, in Bethesda, Maryland. At the workshop, participants identified the scientific challenges facing the field of climate science and outlined the research directions of highest priority that should be pursued to meet these challenges. Representatives from the national and international climate change research community as well as representatives from the high-performance computing community attended the workshop. This group represented a broad mix of expertise. Of the 99 participants, 6 were from international institutions. Before the workshop, each of the four panels prepared a white paper, which provided the starting place for the workshop discussions. These four panels of workshop attendees devoted to their efforts the following themes: Model Development and Integrated Assessment; Algorithms and Computational Environment; Decadal Predictability and Prediction; Data, Visualization, and Computing Productivity. The recommendations of the panels are summarized in the body of this report.

  13. Electronic Banking in Nigeria: Concepts, Challenges and Prospects ...

    African Journals Online (AJOL)

    Electronic Banking in Nigeria: Concepts, Challenges and Prospects. ... examined its prospects for Nigerian banks and discussed associated risks. ... E banking, it also observed, holds enormous potentials for the banking industry in Nigeria.

  14. The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation.

    Science.gov (United States)

    Lewis, Jedediah K; Bischof, John C; Braslavsky, Ido; Brockbank, Kelvin G M; Fahy, Gregory M; Fuller, Barry J; Rabin, Yoed; Tocchio, Alessandro; Woods, Erik J; Wowk, Brian G; Acker, Jason P; Giwa, Sebastian

    2016-04-01

    The first Organ Banking Summit was convened from Feb. 27 - March 1, 2015 in Palo Alto, CA, with events at Stanford University, NASA Research Park, and Lawrence Berkeley National Labs. Experts at the summit outlined the potential public health impact of organ banking, discussed the major remaining scientific challenges that need to be overcome in order to bank organs, and identified key opportunities to accelerate progress toward this goal. Many areas of public health could be revolutionized by the banking of organs and other complex tissues, including transplantation, oncofertility, tissue engineering, trauma medicine and emergency preparedness, basic biomedical research and drug discovery - and even space travel. Key remaining scientific sub-challenges were discussed including ice nucleation and growth, cryoprotectant and osmotic toxicities, chilling injury, thermo-mechanical stress, the need for rapid and uniform rewarming, and ischemia/reperfusion injury. A variety of opportunities to overcome these challenge areas were discussed, i.e. preconditioning for enhanced stress tolerance, nanoparticle rewarming, cyroprotectant screening strategies, and the use of cryoprotectant cocktails including ice binding agents. Copyright © 2015.

  15. A Federal Vision for Future Computing: A Nanotechnology-Inspired Grand Challenge

    Science.gov (United States)

    2016-07-29

    fault-tolerant system that consumes less power than an incandescent light bulb. Recent progress in developing novel, low-power methods of sensing and...computation—including neuromorphic, magneto-electronic, and analog systems—combined with dramatic advances in neuroscience and cognitive sciences...enable ready-to-fabricate designs and specifications. 4. Brain-Inspired Approaches Neuroscience research suggests that the brain is a complex, high

  16. Lessons learned from participating in D3R 2016 Grand Challenge 2: compounds targeting the farnesoid X receptor

    Science.gov (United States)

    Duan, Rui; Xu, Xianjin; Zou, Xiaoqin

    2018-01-01

    D3R 2016 Grand Challenge 2 focused on predictions of binding modes and affinities for 102 compounds against the farnesoid X receptor (FXR). In this challenge, two distinct methods, a docking-based method and a template-based method, were employed by our team for the binding mode prediction. For the new template-based method, 3D ligand similarities were calculated for each query compound against the ligands in the co-crystal structures of FXR available in Protein Data Bank. The binding mode was predicted based on the co-crystal protein structure containing the ligand with the best ligand similarity score against the query compound. For the FXR dataset, the template-based method achieved a better performance than the docking-based method on the binding mode prediction. For the binding affinity prediction, an in-house knowledge-based scoring function ITScore2 and MM/PBSA approach were employed. Good performance was achieved for MM/PBSA, whereas the performance of ITScore2 was sensitive to ligand composition, e.g. the percentage of carbon atoms in the compounds. The sensitivity to ligand composition could be a clue for the further improvement of our knowledge-based scoring function.

  17. Physics and the canalization of morphogenesis: a grand challenge in organismal biology

    International Nuclear Information System (INIS)

    Von Dassow, Michelangelo; Davidson, Lance A

    2011-01-01

    Morphogenesis takes place against a background of organism-to-organism and environmental variation. Therefore, fundamental questions in the study of morphogenesis include: How are the mechanical processes of tissue movement and deformation affected by that variability, and in turn, how do the mechanic of the system modulate phenotypic variation? We highlight a few key factors, including environmental temperature, embryo size and environmental chemistry that might perturb the mechanics of morphogenesis in natural populations. Then we discuss several ways in which mechanics—including feedback from mechanical cues—might influence intra-specific variation in morphogenesis. To understand morphogenesis it will be necessary to consider whole-organism, environment and evolutionary scales because these larger scales present the challenges that developmental mechanisms have evolved to cope with. Studying the variation organisms express and the variation organisms experience will aid in deciphering the causes of birth defects

  18. Psychological science's contributions to a sustainable environment: extending our reach to a grand challenge of society.

    Science.gov (United States)

    Kazdin, Alan E

    2009-01-01

    Climate change and degradation of the environment are global problems associated with many other challenges (e.g., population increases, reduction of glaciers, and loss of critical habitats). Psychological science can play a critical role in addressing these problems by fostering a sustainable environment. Multiple strategies for fostering a sustainable environment could draw from the diversity of topics and areas of specialization within psychology. Psychological research on fostering environmentally sustainable behaviors is rather well developed, as illustrated by interventions focusing on education of the public, message framing, feedback, decision making, the media, incentives and disincentives, and social marketing. Other sciences and professions as well as religion and ethics are actively involved in fostering a sustainable environment. Psychology ought to be more involved directly, systematically, and visibly to draw on our current knowledge and to have palpable impact. We would serve the world very well and in the process our discipline and profession.

  19. Tipping Points and Balancing Acts: Grand Challenges and Synergistic Opportunities of Integrating Research and Education, Science and Solutions

    Science.gov (United States)

    McCaffrey, M. S.; Stroeve, J. C.

    2011-12-01

    The "Grand Challenges" to address Global Change identified by the International Council for Science (ICSU) and its partners through the Earth System Sustainability Initiative-improving forecasting, enhancing and integrating observation systems, confining and minimizing global environmental change, responding effectively to change, as well as innovating and evaluating these efforts-require an integrative approach that engages and inspires society in general and young people in particular. What are some of the effective strategies-and stumbling blocks-in being able to make Earth System science and related sustainability efforts relevant and practical to non-technical audiences? Recent climate education projects have pioneered new strategies toward linking and infusing research with education, science with solutions. For example, the Climate Literacy and Energy Awareness Network (CLEAN), a National Science Digital Library Pathway funded by NSF, has approached this integral approach by "closing the loop" between climate and energy topics, identifying and annotating high quality online resources relating to the carbon cycle and related topics. The Inspiring Climate Education Excellence (ICEE) project, funded by NASA, offers professional development for teachers that infuses climate science with solutions as an emerging "best practice" while being sensitive to the emotional, psychological and political aspects of avoiding "gloom and doom" on one hand or advocating for particular policy solutions on another. Other examples includes NASA's climate website (http://climate.nasa.gov ), which serves as a robust, engaging portal for climate research and data, especially for educators. The recent PBS series Earth: The Operators' Manual and related book and website are other recent example of how climate science research, education and solutions can be incorporated in a way that is appealing and informative. The Alliance for Climate Education (ACE) has given assemblies in

  20. Nuclear physics: large instruments and challenges; La physique nucleaire: les grands instruments et les defis

    Energy Technology Data Exchange (ETDEWEB)

    Harar, S. [CEA Centre d`Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France). Direction des Sciences de la Matiere

    1997-12-31

    Researches on nuclear physics and atomic nucleus can be divided into three periods of time at the CEA: from 1950 to 1970, the characteristics of atomic nucleus structure are measured and accelerators are used; in the early 70`s, heavy ion physics, with the Ganil accelerator, allows for the study of large perturbations in nuclei, while the meson physics study the nucleon interactions using the Saclay 700 MeV electron linear accelerator. In the early 90`s, the radioactive beams provided by the SPIRAL/Ganil device allows for the study of the nucleon internal structure, the quarks, and their effects while their deconfinement is studied by the means of the relativistic heavy ions provided by the LHC accelerator

  1. CAWR: Two institutions join forces in a cluster by addressing the grand challenges of water research

    Science.gov (United States)

    Jaeckel, Greta; Braeckevelt, Mareike

    2017-04-01

    The Center for Advanced Water Research (CAWR) brings together the water competences of two German research institutions: Helmholtz Centre for Environmental Research - UFZ and the Technische Universität Dresden (TUD). Highly qualified scientists are jointly tackling some of the key challenges in the water sector in an outstanding breadth of research topics and at the same time with a profound disciplinary expertise. Our mission is: "Save water for humans and environment", because water in a good quality and adequate quantity is a fundamental basis of life for humankind and the environment. In many global challenges, such as food or energy security, human health and ecosystems, flood defence and droughts or the provision of drinking water and sanitation systems, water is becoming a very critical element for a sustainable society in Germany, in Europe and worldwide. The CAWR focusses its work on the fields of research, education & training as well as transfer. The CAWR was established in 2013. Over 3 years the activities within the three pillars and the six thematic priority research fields ( 1) Understanding processes: water cycle and water quality, 2): Water quantity and scarcity in the regional context, 3): Urban Water Systems, 4): Methods of data collection and information processing, 5): Societal and climate change, 6): Water governance) were presented within: • the scientific community (newsletters, publication highlights, workshops with different new formats, conferences) • to national and international stakeholders from policy, industry and society (workshops, opinion papers) • public media (TV, radio stations, Newspapers, brochures, videoclips via youtube…) This PICO presentation by Greta Jäckel (scientific management of CAWR) should show which tools for the presentation of research results are useful and which influence they have on different target groups. A bunch of examples for effective and also less successful instruments to present important

  2. The grand challenge of great ape health and conservation in the anthropocene.

    Science.gov (United States)

    Travis, Dominic A; Lonsorf, Elizabeth V; Gillespie, Thomas R

    2018-01-01

    "Ecosystem Health recognizes the inherent interdependence of the health of humans, animals and ecosystems and explores the perspectives, theories and methodologies emerging at the interface between ecological and health sciences." This broad focus requires new approaches and methods for solving problems of greater complexity at larger scales than ever before. Nowhere is this point more salient than the case of disease emergence and control at the human-non human primate interface in shrinking tropical forests under great anthropogenic pressure. This special edition brings together transdisciplinary experts who have created successful partnerships leading to advances in ecosystem approaches to health for wild ape populations with relevance to all developing country tropical forest environments. It is no coincidence that the advances herein highlight two long term health projects-the Gombe Ecosystem Health Project (Gombe National Park, Tanzania), and the Taï Chimpanzee Project (TCP) in Côte d'Ivoire-since standardizing and validating noninvasive disease surveillance, risk assessment and management methods presents a special series of challenges where time is a major factor. Advances highlighted in this addition include: health surveillance and monitoring, health risk analysis, field immobilization and interventions, human-NHP networks/interfaces, diagnostic tool development, and cutting edge molecular and genetic techniques. © 2017 Wiley Periodicals, Inc.

  3. Scientific Grand Challenges: Forefront Questions in Nuclear Science and the Role of High Performance Computing

    International Nuclear Information System (INIS)

    Khaleel, Mohammad A.

    2009-01-01

    This report is an account of the deliberations and conclusions of the workshop on 'Forefront Questions in Nuclear Science and the Role of High Performance Computing' held January 26-28, 2009, co-sponsored by the U.S. Department of Energy (DOE) Office of Nuclear Physics (ONP) and the DOE Office of Advanced Scientific Computing (ASCR). Representatives from the national and international nuclear physics communities, as well as from the high performance computing community, participated. The purpose of this workshop was to (1) identify forefront scientific challenges in nuclear physics and then determine which-if any-of these could be aided by high performance computing at the extreme scale; (2) establish how and why new high performance computing capabilities could address issues at the frontiers of nuclear science; (3) provide nuclear physicists the opportunity to influence the development of high performance computing; and (4) provide the nuclear physics community with plans for development of future high performance computing capability by DOE ASCR.

  4. Scientific Grand Challenges: Forefront Questions in Nuclear Science and the Role of High Performance Computing

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, Mohammad A.

    2009-10-01

    This report is an account of the deliberations and conclusions of the workshop on "Forefront Questions in Nuclear Science and the Role of High Performance Computing" held January 26-28, 2009, co-sponsored by the U.S. Department of Energy (DOE) Office of Nuclear Physics (ONP) and the DOE Office of Advanced Scientific Computing (ASCR). Representatives from the national and international nuclear physics communities, as well as from the high performance computing community, participated. The purpose of this workshop was to 1) identify forefront scientific challenges in nuclear physics and then determine which-if any-of these could be aided by high performance computing at the extreme scale; 2) establish how and why new high performance computing capabilities could address issues at the frontiers of nuclear science; 3) provide nuclear physicists the opportunity to influence the development of high performance computing; and 4) provide the nuclear physics community with plans for development of future high performance computing capability by DOE ASCR.

  5. Challenges in implementing electronic hand hygiene monitoring systems.

    Science.gov (United States)

    Conway, Laurie J

    2016-05-02

    Electronic hand hygiene (HH) monitoring systems offer the exciting prospect of a more precise, less biased measure of HH performance than direct observation. However, electronic systems are challenging to implement. Selecting a system that minimizes disruption to the physical infrastructure and to clinician workflow, and that fits with the organization's culture and budget, is challenging. Getting front-line workers' buy-in and addressing concerns about the accuracy of the system and how the data will be used are also difficult challenges. Finally, ensuring information from the system reaches front-line workers and is used by them to improve HH practice is a complex challenge. We describe these challenges in detail and suggests ways to overcome them. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  6. Large scale free energy calculations for blind predictions of protein-ligand binding: the D3R Grand Challenge 2015.

    Science.gov (United States)

    Deng, Nanjie; Flynn, William F; Xia, Junchao; Vijayan, R S K; Zhang, Baofeng; He, Peng; Mentes, Ahmet; Gallicchio, Emilio; Levy, Ronald M

    2016-09-01

    We describe binding free energy calculations in the D3R Grand Challenge 2015 for blind prediction of the binding affinities of 180 ligands to Hsp90. The present D3R challenge was built around experimental datasets involving Heat shock protein (Hsp) 90, an ATP-dependent molecular chaperone which is an important anticancer drug target. The Hsp90 ATP binding site is known to be a challenging target for accurate calculations of ligand binding affinities because of the ligand-dependent conformational changes in the binding site, the presence of ordered waters and the broad chemical diversity of ligands that can bind at this site. Our primary focus here is to distinguish binders from nonbinders. Large scale absolute binding free energy calculations that cover over 3000 protein-ligand complexes were performed using the BEDAM method starting from docked structures generated by Glide docking. Although the ligand dataset in this study resembles an intermediate to late stage lead optimization project while the BEDAM method is mainly developed for early stage virtual screening of hit molecules, the BEDAM binding free energy scoring has resulted in a moderate enrichment of ligand screening against this challenging drug target. Results show that, using a statistical mechanics based free energy method like BEDAM starting from docked poses offers better enrichment than classical docking scoring functions and rescoring methods like Prime MM-GBSA for the Hsp90 data set in this blind challenge. Importantly, among the three methods tested here, only the mean value of the BEDAM binding free energy scores is able to separate the large group of binders from the small group of nonbinders with a gap of 2.4 kcal/mol. None of the three methods that we have tested provided accurate ranking of the affinities of the 147 active compounds. We discuss the possible sources of errors in the binding free energy calculations. The study suggests that BEDAM can be used strategically to discriminate

  7. Communicating Geosciences with Policy-makers: a Grand Challenge for Academia

    Science.gov (United States)

    Harrison, W. J.; Walls, M. R.; Boland, M. A.

    2015-12-01

    Geoscientists interested in the broader societal impacts of their research can make a meaningful contribution to policy making in our changing world. Nevertheless, policy and public decision making are the least frequently cited Broader Impacts in proposals and funded projects within NSF's Geosciences Directorate. Academic institutions can play a lead role by introducing this societal dimension of our profession to beginning students, and by enabling interdisciplinary research and promoting communication pathways for experienced career geoscientists. Within the academic environment, the public interface of the geosciences can be presented through curriculum content and creative programs. These include undergraduate minors in economics or public policy designed for scientists and engineers, and internships with policy makers. Federal research institutions and other organizations provide valuable policy-relevant experiences for students. Academic institutions have the key freedom of mission to tackle interdisciplinary research challenges at the interface of geoscience and policy. They develop long-standing relationships with research partners, including national laboratories and state geological surveys, whose work may support policy development and analysis at local, state, regional, and national levels. CSM's Payne Institute for Earth Resources awards mini-grants for teams of researchers to develop collaborative research efforts between engineering/science and policy researchers. Current work in the areas of nuclear generation and the costs of climate policy and on policy alternatives for capturing fugitive methane emissions are examples of work at the interface between the geosciences and public policy. With academic engagement, geoscientists can steward their intellectual output when non-scientists translate geoscience information and concepts into action through public policies.

  8. AI in medical education--another grand challenge for medical informatics.

    Science.gov (United States)

    Lillehaug, S I; Lajoie, S P

    1998-03-01

    The potential benefits of artificial intelligence in medicine (AIM) were never realized as anticipated. This paper addresses ways in which such potential can be achieved. Recent discussions of this topic have proposed a stronger integration between AIM applications and health information systems, and emphasize computer guidelines to support the new health care paradigms of evidence-based medicine and cost-effectiveness. These proposals, however, promote the initial definition of AIM applications as being AI systems that can perform or aid in diagnoses. We challenge this traditional philosophy of AIM and propose a new approach aiming at empowering health care workers to become independent self-sufficient problem solvers and decision makers. Our philosophy is based on findings from a review of empirical research that examines the relationship between the health care personnel's level of knowledge and skills, their job satisfaction, and the quality of the health care they provide. This review supports addressing the quality of health care by empowering health care workers to reach their full potential. As an aid in this empowerment process we argue for reviving a long forgotten AIM research area, namely, AI based applications for medical education and training. There is a growing body of research in artificial intelligence in education that demonstrates that the use of artificial intelligence can enhance learning in numerous domains. By examining the strengths of these educational applications and the results from previous AIM research we derive a framework for empowering medical personnel and consequently raising the quality of health care through the use of advanced AI based technology.

  9. Grand challenges in developing a predictive understanding of global fire dynamics

    Science.gov (United States)

    Randerson, J. T.; Chen, Y.; Wiggins, E. B.; Andela, N.; Morton, D. C.; Veraverbeke, S.; van der Werf, G.

    2017-12-01

    High quality satellite observations of burned area and fire thermal anomalies over the past two decades have transformed our understanding of climate, ecosystem, and human controls on the spatial and temporal distribution of landscape fires. The satellite observations provide evidence for a rapid and widespread loss of fire from grassland and savanna ecosystems worldwide. Continued expansion of industrial agriculture suggests that observed declines in global burned area are likely to continue in future decades, with profound consequences for ecosystem function and the habitat of many endangered species. Satellite time series also highlight the importance of El Niño-Southern Oscillation and other climate modes as drivers of interannual variability. In many regions, lead times between climate indices and fire activity are considerable, enabling the development of early warning prediction systems for fire season severity. With the recent availability of high-resolution observations from Suomi NPP, Landsat 8, and Sentinel 2, the field of global fire ecology is poised to make even more significant breakthroughs over the next decade. With these new observations, it may be possible to reduce uncertainties in the spatial pattern of burned area by several fold. It is difficult to overstate the importance of these new data constraints for improving our understanding of fire impacts on human health and radiative forcing of climate change. A key research challenge in this context is to understand how the loss of global burned area will affect magnitude of the terrestrial carbon sink and trends in atmospheric composition. Advances in prognostic fire modeling will require new approaches linking agriculture with landscape fire dynamics. A critical need in this context is the development of predictive models of road networks and other drivers of land fragmentation, and a closer integration of fragmentation information with algorithms predicting fire spread. Concurrently, a better

  10. Combining Multidisciplinary Science, Quantitative Reasoning and Social Context to Teach Global Sustainability and Prepare Students for 21st Grand Challenges

    Science.gov (United States)

    Myers, J. D.

    2011-12-01

    The Earth's seven billion humans are consuming a growing proportion of the world's ecosystem products and services. Human activity has also wrought changes that rival the scale of many natural geologic processes, e.g. erosion, transport and deposition, leading to recognition of a new geological epoch, the Anthropocene. Because of these impacts, several natural systems have been pushed beyond the planetary boundaries that made the Holocene favorable for the expansion of humanity. Given these human-induced stresses on natural systems, global citizens will face an increasing number of grand challenges. Unfortunately, traditional discipline-based introductory science courses do little to prepare students for these complex, scientifically-based and technologically-centered challenges. With NSF funding, an introductory, integrated science course stressing quantitative reasoning and social context has been created at UW. The course (GEOL1600: Global Sustainability: Managing the Earth's Resources) is a lower division course designed around the energy-water-climate (EWC) nexus and integrating biology, chemistry, Earth science and physics. It melds lectures, lecture activities, reading questionnaires and labs to create a learning environment that examines the EWT nexus from a global through regional context. The focus on the EWC nexus, while important socially and intended to motivate students, also provides a coherent framework for identifying which disciplinary scientific principles and concepts to include in the course: photosynthesis and deep time (fossil fuels), biogeochemical cycles (climate), chemical reactions (combustion), electromagnetic radiation (solar power), nuclear physics (nuclear power), phase changes and diagrams (water and climate), etc. Lecture activities are used to give students the practice they need to make quantitative skills routine and automatic. Laboratory exercises on energy (coal, petroleum, nuclear power), water (in Bangladesh), energy

  11. Shared Electronic Health Record Systems: Key Legal and Security Challenges.

    Science.gov (United States)

    Christiansen, Ellen K; Skipenes, Eva; Hausken, Marie F; Skeie, Svein; Østbye, Truls; Iversen, Marjolein M

    2017-11-01

    Use of shared electronic health records opens a whole range of new possibilities for flexible and fruitful cooperation among health personnel in different health institutions, to the benefit of the patients. There are, however, unsolved legal and security challenges. The overall aim of this article is to highlight legal and security challenges that should be considered before using shared electronic cooperation platforms and health record systems to avoid legal and security "surprises" subsequent to the implementation. Practical lessons learned from the use of a web-based ulcer record system involving patients, community nurses, GPs, and hospital nurses and doctors in specialist health care are used to illustrate challenges we faced. Discussion of possible legal and security challenges is critical for successful implementation of shared electronic collaboration systems. Key challenges include (1) allocation of responsibility, (2) documentation routines, (3) and integrated or federated access control. We discuss and suggest how challenges of legal and security aspects can be handled. This discussion may be useful for both current and future users, as well as policy makers.

  12. Grand Challenge Problem 10

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Lone; Balacheff, Nicolas; Bottino, Rosa Maria

    2016-01-01

    Small and medium sized research labs (SMLs) are dominating European TEL research. This is justified by the great numbers of countries and regions in Europe needing to develop a research and innovation competence to facilitate the diverse educational systems contextualized in various institutional...

  13. Electronic Payment System in Nigeria: Its Economic Benefits and Challenges

    Science.gov (United States)

    Okifo, Joseph; Igbunu, Richard

    2015-01-01

    The crux of this study is on the adoption of E-payment system in Nigeria: Its economic benefits and challenges. The arrival of the internet has taken electronic payments and transactions to an exponential growth level. Consumers could purchase goods and services from the internet and send unencrypted credit card numbers across the network, which…

  14. Electronics and triggering challenges for the CMS High Granularity Calorimeter

    Science.gov (United States)

    Lobanov, A.

    2018-02-01

    The High Granularity Calorimeter (HGCAL), presently being designed by the CMS collaboration to replace the CMS endcap calorimeters for the High Luminosity phase of LHC, will feature six million channels distributed over 52 longitudinal layers. The requirements for the front-end electronics are extremely challenging, including high dynamic range (0.2 fC-10 pC), low noise (~2000 e- to be able to calibrate on single minimum ionising particles throughout the detector lifetime) and low power consumption (~20 mW/channel), as well as the need to select and transmit trigger information with a high granularity. Exploiting the intrinsic precision-timing capabilities of silicon sensors also requires careful design of the front-end electronics as well as the whole system, particularly clock distribution. The harsh radiation environment and requirement to keep the whole detector as dense as possible will require novel solutions to the on-detector electronics layout. Processing the data from the HGCAL imposes equally large challenges on the off-detector electronics, both for the hardware and incorporated algorithms. We present an overview of the complete electronics architecture, as well as the performance of prototype components and algorithms.

  15. Integrating an Academic Electronic Health Record: Challenges and Success Strategies.

    Science.gov (United States)

    Herbert, Valerie M; Connors, Helen

    2016-08-01

    Technology is increasing the complexity in the role of today's nurse. Healthcare organizations are integrating more health information technologies and relying on the electronic health record for data collection, communication, and decision making. Nursing faculty need to prepare graduates for this environment and incorporate an academic electronic health record into a nursing curriculum to meet student-program outcomes. Although the need exists for student preparation, some nursing programs are struggling with implementation, whereas others have been successful. To better understand these complexities, this project was intended to identify current challenges and success strategies of effective academic electronic health record integration into nursing curricula. Using Rogers' 1962 Diffusion of Innovation theory as a framework for technology adoption, a descriptive survey design was used to gain insights from deans and program directors of nursing schools involved with the national Health Informatics & Technology Scholars faculty development program or Cerner's Academic Education Solution Consortium, working to integrate an academic electronic health record in their respective nursing schools. The participants' experiences highlighted approaches used by these schools to integrate these technologies. Data from this project provide nursing education with effective strategies and potential challenges that should be addressed for successful academic electronic health record integration.

  16. Electronic health records challenges in design and implementation

    CERN Document Server

    Sittig, Dean F

    2013-01-01

    This book provides an overview of the challenges in electronic health records (EHR) design and implementation along with an introduction to the best practices that have been identified over the past several years. The book examines concerns surrounding EHR use and proposes eight examples of proper EHR use. It discusses the complex strategic planning that accompanies the systemic organizational changes associated with EHR programs and highlights key lessons learned regarding health information-including technology errors and risk management concerns.

  17. Meeting the Grand Challenge of Protecting Astronauts Health: Electrostatic Active Space Radiation Shielding for Deep Space Missions

    Science.gov (United States)

    Tripathi, Ram K.

    2016-01-01

    membrane structure (EIMS) in both charged and uncharged configurations. The amount of charge shielding behind and around the EIMS was studied for different combinations of membrane structure voltages and electron energies. Both passive and active shielding were observed, with active shielding capable of deflecting nearly all incoming electrons. The pattern of charge distribution around the structure was studied as well as the stability of the structures in the charge flow. The charge deflection experiments illustrate that the EIMS remain inflated during charge deflection, but will experience small amplitude oscillations. Investigations were performed to determine a potential cause of the vibrations. It is postulated these vibrations are due to the charge flux causing local membrane charge distribution changes. As the membrane structure inflation pressure is changed, the shape responds, and causes the observed sustained vibration. Having identified this phenomenon is important when considering electrostatically inflated membrane structures (EIMS) in a space environment. Additionally, this project included a study of membrane material impacts, specifically the impact of membrane thickness. Extremely thin materials presented new challenges with vacuum preparation techniques and rapid charging. The thinner and lighter membrane materials were successfully inflated using electrostatic forces in a vacuum chamber. However, care must be taken when varying the potentials of such lighter structures as the currents can cause local heating and melting of the very thin membranes. Lastly, a preliminary analysis is performed to study rough order of magnitude power requirements for using EIMS for radiation shielding. The EIMS power requirement becomes increasingly more challenging as the spacecraft voltage is increased. As a result, the emphasis is on the deflection of charges away from the spacecraft rather than totally stopping them. This significantly alleviates the initial power

  18. Electronic health systems: challenges faced by hospital-based providers.

    Science.gov (United States)

    Agno, Christina Farala; Guo, Kristina L

    2013-01-01

    The purpose of this article is to discuss specific challenges faced by hospitals adopting the use of electronic medical records and implementing electronic health record (EHR) systems. Challenges include user and information technology support; ease of technical use and software interface capabilities; compliance; and financial, legal, workforce training, and development issues. Electronic health records are essential to preventing medical errors, increasing consumer trust and use of the health system, and improving quality and overall efficiency. Government efforts are focused on ways to accelerate the adoption and use of EHRs as a means of facilitating data sharing, protecting health information privacy and security, quickly identifying emerging public health threats, and reducing medical errors and health care costs and increasing quality of care. This article will discuss physician and nonphysician staff training before, during, and after implementation; the effective use of EHR systems' technical features; the selection of a capable and secure EHR system; and the development of collaborative system implementation. Strategies that are necessary to help health care providers achieve successful implementation of EHR systems will be addressed.

  19. Challenges in reduction of dinitrogen by proton and electron transfer.

    Science.gov (United States)

    van der Ham, Cornelis J M; Koper, Marc T M; Hetterscheid, Dennis G H

    2014-08-07

    Ammonia is an important nutrient for the growth of plants. In industry, ammonia is produced by the energy expensive Haber-Bosch process where dihydrogen and dinitrogen form ammonia at a very high pressure and temperature. In principle one could also reduce dinitrogen upon addition of protons and electrons similar to the mechanism of ammonia production by nitrogenases. Recently, major breakthroughs have taken place in our understanding of biological fixation of dinitrogen, of molecular model systems that can reduce dinitrogen, and in the electrochemical reduction of dinitrogen at heterogeneous surfaces. Yet for efficient reduction of dinitrogen with protons and electrons major hurdles still have to be overcome. In this tutorial review we give an overview of the different catalytic systems, highlight the recent breakthroughs, pinpoint common grounds and discuss the bottlenecks and challenges in catalytic reduction of dinitrogen.

  20. Sustainable Materials Management (SMM) Web Academy Webinar: EPA's SMM Electronics Challenge - What's in it for you?

    Science.gov (United States)

    There will be a webinar entitled, EPA’s SMM Electronics Challenge: What’s in it for you?” to hear how the Challenge can help you preserve the environment, demonstrate leadership by building more sustainable electronics.

  1. The Challenges of Becoming Tutors at Electronic Environments

    Directory of Open Access Journals (Sweden)

    María Eugenia López Hurtado

    2014-07-01

    Full Text Available This paper presents a research report of my own experience as a tutor in electronic environments which I have accumulated throughout the guidance for English learners of basic level at a public university. This article looks for illustrating the researcher's own perceptions and challenges as becoming an e-tutor. Therefore, I will introduce an overview of studies and experiences that address this issue in international contexts, and then I will refer to my own experience where I describe the roles that emerged while I was administrating and delivering e- learning pedagogical experiences such as an exploration of some skills and learning activities carried out in an English course; this description embraces three different stages (before, during and after of implementation. Subsequently, some discussion of the results is provided gathered from the research instruments I used. Finally, some conclusions and suggestions are provided in regards to the research question of the study, its outcomes on how tutors' challenges shape tutor's roles in electronic environments.

  2. Predicting the affinity of Farnesoid X Receptor ligands through a hierarchical ranking protocol: a D3R Grand Challenge 2 case study

    Science.gov (United States)

    Réau, Manon; Langenfeld, Florent; Zagury, Jean-François; Montes, Matthieu

    2018-01-01

    The Drug Design Data Resource (D3R) Grand Challenges are blind contests organized to assess the state-of-the-art methods accuracy in predicting binding modes and relative binding free energies of experimentally validated ligands for a given target. The second stage of the D3R Grand Challenge 2 (GC2) was focused on ranking 102 compounds according to their predicted affinity for Farnesoid X Receptor. In this task, our workflow was ranked 5th out of the 77 submissions in the structure-based category. Our strategy consisted in (1) a combination of molecular docking using AutoDock 4.2 and manual edition of available structures for binding poses generation using SeeSAR, (2) the use of HYDE scoring for pose selection, and (3) a hierarchical ranking using HYDE and MM/GBSA. In this report, we detail our pose generation and ligands ranking protocols and provide guidelines to be used in a prospective computer aided drug design program.

  3. The use of the Climate-science Computational End Station (CCES) development and grand challenge team for the next IPCC assessment: an operational plan

    International Nuclear Information System (INIS)

    Washington, W M; Buja, L; Gent, P; Drake, J; Erickson, D; Anderson, D; Bader, D; Dickinson, R; Ghan, S; Jones, P; Jacob, R

    2008-01-01

    The grand challenge of climate change science is to predict future climates based on scenarios of anthropogenic emissions and other changes resulting from options in energy and development policies. Addressing this challenge requires a Climate Science Computational End Station consisting of a sustained climate model research, development, and application program combined with world-class DOE leadership computing resources to enable advanced computational simulation of the Earth system. This project provides the primary computer allocations for the DOE SciDAC and Climate Change Prediction Program. It builds on the successful interagency collaboration of the National Science and the U.S. Department of Energy in developing and applying the Community Climate System Model (CCSM) for climate change science. It also includes collaboration with the National Aeronautics and Space Administration in carbon data assimilation and university partners with expertise in high-end computational climate research

  4. Long-term Water Table Monitoring of Rio Grande Riparian Ecosystems for Restoration Potential Amid Hydroclimatic Challenges

    Science.gov (United States)

    Thibault, James R.; Cleverly, James R.; Dahm, Clifford N.

    2017-12-01

    Hydrological processes drive the ecological functioning and sustainability of cottonwood-dominated riparian ecosystems in the arid southwestern USA. Snowmelt runoff elevates groundwater levels and inundates floodplains, which promotes cottonwood germination. Once established, these phreatophytes rely on accessible water tables (WTs). In New Mexico's Middle Rio Grande corridor diminished flooding and deepening WTs threaten native riparian communities. We monitored surface flows and riparian WTs for up to 14 years, which revealed that WTs and surface flows, including peak snowmelt discharge, respond to basin climate conditions and resource management. WT hydrographs influence the composition of riparian communities and can be used to assess if potential restoration sites meet native vegetation tolerances for WT depths, rates of recession, and variability throughout their life stages. WTs were highly variable in some sites, which can preclude native vegetation less adapted to deep drawdowns during extended droughts. Rates of WT recession varied between sites and should be assessed in regard to recruitment potential. Locations with relatively shallow WTs and limited variability are likely to be more viable for successful restoration. Suitable sites have diminished greatly as the once meandering Rio Grande has been constrained and depleted. Increasing demands on water and the presence of invasive vegetation better adapted to the altered hydrologic regime further impact native riparian communities. Long-term monitoring over a range of sites and hydroclimatic extremes reveals attributes that can be evaluated for restoration potential.

  5. Front-end electronics and trigger systems - status and challenges

    International Nuclear Information System (INIS)

    Spieler, Helmuth G; Spieler, Helmuth G

    2007-01-01

    The past quarter century has brought about a revolution in front-end electronics for large-scale detector systems. Custom integrated circuits specifically tailored to the requirements of large detector systems have provided unprecedented performance and enabled systems that once were deemed impossible. The evolution of integrated circuit readouts in strip detectors is summarized, the present status described, and challenges posed by the sLHC and ILC are discussed. Performance requirements increase, but key considerations remain as in the past: power dissipation, material, and services. Smaller CMOS feature sizes will not provide the required electronic noise at lower power, but will improve digital power efficiency. Significant improvements appear to be practical in more efficient power distribution. Enhanced digital electronics have provided powerful trigger processors that greatly improve the trigger efficiency. In data readout systems they also improve data throughput, while reducing power requirements. Concurrently with new developments in high energy physics, detector systems for cosmology and astrophysics have made great strides. As an example, a large-scale readout for superconducting bolometer arrays is described

  6. Electronics and triggering challenges for the CMS High Granularity Calorimeter

    CERN Document Server

    Lobanov, Artur

    2017-01-01

    The High Granularity Calorimeter (HGCAL), presently being designed by the CMS collaboration to replace the CMS endcap calorimeters for the High Luminosity phase of LHC, will feature six million channels distributed over 52 longitudinal layers. The requirements for the front-end electronics are extremely challenging, including high dynamic range (0-10 pC), low noise (~2000e- to be able to calibrate on single minimum ionising particles throughout the detector lifetime) and low power consumption (~10mW/channel), as well as the need to select and transmit trigger information with a high granularity. Exploiting the intrinsic precision-timing capabilities of silicon sensors also requires careful design of the front-end electronics as well as the whole system, particularly clock distribution. The harsh radiation environment and requirement to keep the whole detector as dense as possible will require novel solutions to the on-detector electronics layout. Processing all the data from the HGCAL imposes equally large ch...

  7. Implementing electronic health care predictive analytics: considerations and challenges.

    Science.gov (United States)

    Amarasingham, Ruben; Patzer, Rachel E; Huesch, Marco; Nguyen, Nam Q; Xie, Bin

    2014-07-01

    The use of predictive modeling for real-time clinical decision making is increasingly recognized as a way to achieve the Triple Aim of improving outcomes, enhancing patients' experiences, and reducing health care costs. The development and validation of predictive models for clinical practice is only the initial step in the journey toward mainstream implementation of real-time point-of-care predictions. Integrating electronic health care predictive analytics (e-HPA) into the clinical work flow, testing e-HPA in a patient population, and subsequently disseminating e-HPA across US health care systems on a broad scale require thoughtful planning. Input is needed from policy makers, health care executives, researchers, and practitioners as the field evolves. This article describes some of the considerations and challenges of implementing e-HPA, including the need to ensure patients' privacy, establish a health system monitoring team to oversee implementation, incorporate predictive analytics into medical education, and make sure that electronic systems do not replace or crowd out decision making by physicians and patients. Project HOPE—The People-to-People Health Foundation, Inc.

  8. Challenges of 4D(ata Model for Electronic Government

    Directory of Open Access Journals (Sweden)

    Bogdan GHILIC-MICU

    2015-01-01

    Full Text Available Social evolution pyramid, built on the foundation of the ‘90s capitalist society, lead to the emergence of the informational society – years 1990 to 2005 – and knowledge society – years 2005 to 2020. The literature starts using a new concept, a new form of association – artificial intelligence society – foreseen to be established in the next time frame. All these developments of human society and translations or leaps (most of the times apparently timeless were, are and will be possible only due to the advancing information and communications technologies. The leap to Democracy 3.0, based on information and communication technologies prompts to a radical change in the majority of the classical concepts targeting society structure and the way it is guided and controlled. Thus, concepts become electronic concepts (or e-concepts through the use of new technologies. E-concepts keep the essence of the classical principles of liberty and democracy, adding a major aspect of the new way of communication and spreading ideas between people. The main problem is to quantify, analyze and foresee the way technological changes will influence not only the economic system, but also the daily life of the individual and the society. Unfortunately (or maybe fortunately, depending on the point of view, all these evolutions and technological and social developments are as many challenges for the governments of the world. In this paper we will highlight only four of the challenges facing the governments, grouped in a structured model with the following specific concepts: Big Data, Social Data, Linked Data and Mobile Data. This is an emerging paradigm of the information and communication technology supporting national and global eGovernment projects.

  9. Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort.

    Science.gov (United States)

    Gao, Ying-Duo; Hu, Yuan; Crespo, Alejandro; Wang, Deping; Armacost, Kira A; Fells, James I; Fradera, Xavier; Wang, Hongwu; Wang, Huijun; Sherborne, Brad; Verras, Andreas; Peng, Zhengwei

    2018-01-01

    The 2016 D3R Grand Challenge 2 includes both pose and affinity or ranking predictions. This article is focused exclusively on affinity predictions submitted to the D3R challenge from a collaborative effort of the modeling and informatics group. Our submissions include ranking of 102 ligands covering 4 different chemotypes against the FXR ligand binding domain structure, and the relative binding affinity predictions of the two designated free energy subsets of 15 and 18 compounds. Using all the complex structures prepared in the same way allowed us to cover many types of workflows and compare their performances effectively. We evaluated typical workflows used in our daily structure-based design modeling support, which include docking scores, force field-based scores, QM/MM, MMGBSA, MD-MMGBSA, and MacroModel interaction energy estimations. The best performing methods for the two free energy subsets are discussed. Our results suggest that affinity ranking still remains very challenging; that the knowledge of more structural information does not necessarily yield more accurate predictions; and that visual inspection and human intervention are considerably important for ranking. Knowledge of the mode of action and protein flexibility along with visualization tools that depict polar and hydrophobic maps are very useful for visual inspection. QM/MM-based workflows were found to be powerful in affinity ranking and are encouraged to be applied more often. The standardized input and output enable systematic analysis and support methodology development and improvement for high level blinded predictions.

  10. Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort

    Science.gov (United States)

    Gao, Ying-Duo; Hu, Yuan; Crespo, Alejandro; Wang, Deping; Armacost, Kira A.; Fells, James I.; Fradera, Xavier; Wang, Hongwu; Wang, Huijun; Sherborne, Brad; Verras, Andreas; Peng, Zhengwei

    2018-01-01

    The 2016 D3R Grand Challenge 2 includes both pose and affinity or ranking predictions. This article is focused exclusively on affinity predictions submitted to the D3R challenge from a collaborative effort of the modeling and informatics group. Our submissions include ranking of 102 ligands covering 4 different chemotypes against the FXR ligand binding domain structure, and the relative binding affinity predictions of the two designated free energy subsets of 15 and 18 compounds. Using all the complex structures prepared in the same way allowed us to cover many types of workflows and compare their performances effectively. We evaluated typical workflows used in our daily structure-based design modeling support, which include docking scores, force field-based scores, QM/MM, MMGBSA, MD-MMGBSA, and MacroModel interaction energy estimations. The best performing methods for the two free energy subsets are discussed. Our results suggest that affinity ranking still remains very challenging; that the knowledge of more structural information does not necessarily yield more accurate predictions; and that visual inspection and human intervention are considerably important for ranking. Knowledge of the mode of action and protein flexibility along with visualization tools that depict polar and hydrophobic maps are very useful for visual inspection. QM/MM-based workflows were found to be powerful in affinity ranking and are encouraged to be applied more often. The standardized input and output enable systematic analysis and support methodology development and improvement for high level blinded predictions.

  11. Challenges in graphene integration for high-frequency electronics

    Science.gov (United States)

    Giannazzo, F.; Fisichella, G.; Greco, G.; Roccaforte, F.

    2016-06-01

    This paper provides an overview of the state-of-the-art research on graphene (Gr) for high-frequency (RF) devices. After discussing current limitations of lateral Gr RF transistors, novel vertical devices concepts such as the Gr Base Hot Electron Transistor (GBHET) will be introduced and the main challenges in Gr integration within these architectures will be discussed. In particular, a GBHET device based on Gr/AlGaN/GaN heterostructure will be considered. An approach to the fabrication of this heterostructure by transfer of CVD grown Gr on copper to the AlGaN surface will be presented. The morphological and electrical properties of this system have been investigated at nanoscale by atomic force microscopy (AFM) and conductive atomic force microscopy (CAFM). In particular, local current-voltage measurements by the CAFM probe revealed the formation of a Schottky contact with low barrier height (˜0.41 eV) and excellent lateral uniformity between Gr and AlGaN. Basing on the electrical parameters extracted from this characterization, the theoretical performances of a GBHET formed by a metal/Al2O3/Gr/AlGaN/GaN stack have been evaluated.

  12. Triggering the GRANDE array

    International Nuclear Information System (INIS)

    Wilson, C.L.; Bratton, C.B.; Gurr, J.; Kropp, W.; Nelson, M.; Sobel, H.; Svoboda, R.; Yodh, G.; Burnett, T.; Chaloupka, V.; Wilkes, R.J.; Cherry, M.; Ellison, S.B.; Guzik, T.G.; Wefel, J.; Gaidos, J.; Loeffler, F.; Sembroski, G.; Goodman, J.; Haines, T.J.; Kielczewska, D.; Lane, C.; Steinberg, R.; Lieber, M.; Nagle, D.; Potter, M.; Tripp, R.

    1990-01-01

    A brief description of the Gamma Ray And Neutrino Detector Experiment (GRANDE) is presented. The detector elements and electronics are described. The trigger logic for the array is then examined. The triggers for the Gamma Ray and the Neutrino portions of the array are treated separately. (orig.)

  13. Combining self- and cross-docking as benchmark tools: the performance of DockBench in the D3R Grand Challenge 2

    Science.gov (United States)

    Salmaso, Veronica; Sturlese, Mattia; Cuzzolin, Alberto; Moro, Stefano

    2018-01-01

    Molecular docking is a powerful tool in the field of computer-aided molecular design. In particular, it is the technique of choice for the prediction of a ligand pose within its target binding site. A multitude of docking methods is available nowadays, whose performance may vary depending on the data set. Therefore, some non-trivial choices should be made before starting a docking simulation. In the same framework, the selection of the target structure to use could be challenging, since the number of available experimental structures is increasing. Both issues have been explored within this work. The pose prediction of a pool of 36 compounds provided by D3R Grand Challenge 2 organizers was preceded by a pipeline to choose the best protein/docking-method couple for each blind ligand. An integrated benchmark approach including ligand shape comparison and cross-docking evaluations was implemented inside our DockBench software. The results are encouraging and show that bringing attention to the choice of the docking simulation fundamental components improves the results of the binding mode predictions.

  14. Addressing the Challenge: Cataloguing Electronic Books in Academic Libraries

    Directory of Open Access Journals (Sweden)

    Shuzhen Zhao

    2010-03-01

    Full Text Available Objective ‐ This paper explores the various issues and challenges arising from e‐book cataloguing experienced at the University of Windsor’s Leddy Library and the Ontario Council of University Libraries (OCUL. This discussion uses an evidence based approach to identify and resolve issues relevant to academic libraries as well as to consortia. With the ever rising popularity of e‐books within academic libraries, cataloguing librarians are actively seeking more effective methods of managing this new electronic medium, including the development of new cataloguing policies and procedures. This paper will explore the various issues and challenges surrounding e‐book cataloguing and processing within academic libraries, and will identify new policies and procedures that may be used to effectively assist in e‐book management.Methods ‐ This paper presents a case study of e‐book cataloguing practices undertaken by a Canadian academic library and the consortium with which it is affiliated. Towards this end, the University of Windsor’s Leddy Library will be the prime focus of this study, with its establishment of a new e‐book MARC records database. The research is based on the results of the e‐book MARC project undertaken by the Leddy Library and the Ontario Council of University Libraries (OCUL.Through analysis of various suppliers’ MARC records and the actual implementation of the e‐book MARC project, the authors developed and evaluated a new approach to e‐book cataloguing for use in academic libraries.Results ‐ This practice‐based approach towards the development of a new method of e‐book cataloguing required continual modification and examination of e‐book MARC records within the target library. The Leddy Library’s e‐book MARC project provided an excellent opportunity to test the library’s existing cataloguing standards and procedures for print format, while at the same time, identifying related e‐books issues

  15. Electronic Waste: A Growing Challenge In Nigeria | Ukem | Global ...

    African Journals Online (AJOL)

    Global Journal of Pure and Applied Sciences ... growing problem of electronic waste from the Nigerian perspective, and highlights factors that can militate ... equipment, electronic waste, recycling, environmental pollution, waste management.

  16. Grandes remolques

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1961-07-01

    Full Text Available El empleo creciente del material pesado auxiliar en la construcción de obras de ingeniería civil ha motivado la fabricación de grandes plataformas, capaces de transportar toda clase de maquinaria auxiliar. En general, este tipo de maquinaria requiere medios de transporte, pues su circulación por carreteras es lenta, obstructiva y cara, siempre que se trate de grandes distancias, caso presente en la mayoría de ocasiones en que se exige un traslado de esta maquinaria de una a otra obra.

  17. Key Concepts for and Assessment of an Undergraduate Class that Engages Engineering Students in Climate Change Grand Challenge

    Science.gov (United States)

    Powers, S. E.; DeWaters, J.; Dhaniyala, S.

    2015-12-01

    Engineers must take a leading role in addressing the challenges of mitigating climate change and adapting to the inevitable changes that our world is facing. Yet climate change classes targeting engineering students are scarce. Technical education must focus on the problem formulation and solutions that consider multiple, complex interactions between engineered systems and the Earth's climate system and recognize that transformation raises societal challenges, including trade-offs among benefits, costs, and risks. Moreover, improving engineering students' climate science literacy will require strategies that also inspire students' motivation to work toward their solution. A climate science course for engineers has been taught 5 semesters as part of a NASA Innovations in Climate Education program grant (NNXlOAB57A). The basic premise of this project was that effective instruction must incorporate scientifically-based knowledge and observations and foster critical thinking, problem solving, and decision-making skills. Lecture, in-class cooperative and computer-based learning and a semester project provide the basis for engaging students in evaluating effective mitigation and adaptation solutions. Policy and social issues are integrated throughout many of the units. The objective of this presentation is to highlight the content and pedagogical approach used in this class that helped to contribute to significant gains in engineering students' climate literacy and critical thinking competencies. A total of 89 students fully participated in a pre/post climate literacy questionnaire. As a whole, students demonstrated significant gains in climate-related content knowledge (pproblem statements and solutions in a manner that incorporated a multidimensional systems perspective. These skills are sometimes foreign to technically focused, number crunching engineering students, but are critical for using their engineering skills and profession to address climate change mitigation

  18. Software Engineering Support of the Third Round of Scientific Grand Challenge Investigations: Earth System Modeling Software Framework Survey

    Science.gov (United States)

    Talbot, Bryan; Zhou, Shu-Jia; Higgins, Glenn; Zukor, Dorothy (Technical Monitor)

    2002-01-01

    One of the most significant challenges in large-scale climate modeling, as well as in high-performance computing in other scientific fields, is that of effectively integrating many software models from multiple contributors. A software framework facilitates the integration task, both in the development and runtime stages of the simulation. Effective software frameworks reduce the programming burden for the investigators, freeing them to focus more on the science and less on the parallel communication implementation. while maintaining high performance across numerous supercomputer and workstation architectures. This document surveys numerous software frameworks for potential use in Earth science modeling. Several frameworks are evaluated in depth, including Parallel Object-Oriented Methods and Applications (POOMA), Cactus (from (he relativistic physics community), Overture, Goddard Earth Modeling System (GEMS), the National Center for Atmospheric Research Flux Coupler, and UCLA/UCB Distributed Data Broker (DDB). Frameworks evaluated in less detail include ROOT, Parallel Application Workspace (PAWS), and Advanced Large-Scale Integrated Computational Environment (ALICE). A host of other frameworks and related tools are referenced in this context. The frameworks are evaluated individually and also compared with each other.

  19. Responses to Environmental & Societal Challenges for our Unstable Earth (RESCUE) foresight initiative - towards a European response to grand challenges in sustainability research and learning

    Science.gov (United States)

    Avril, B.; et al.

    2012-04-01

    The "Responses to Environmental and Societal Challenges for our Unstable Earth" (RESCUE; www.esf.org/rescue) foresight initiative - a joint COST-ESF "Frontiers of Science" initiative - aimed to help Europe address the societal and scientific challenges related to global environmental change and the related resilience issues. In RESCUE, the focus of attention was on people and the goal was to stimulate an integrated, innovative response from natural, social and human sciences. The RESCUE foresight initiative began in September 2009 and has recently been completed. RESCUE had the following key objectives: 1. To propose a strategic process for natural, social and human sciences to improve their ability and capacity to work together to address global environmental change through interdisciplinary synergy and to respond effectively to societal and policy-relevant needs; 2. To articulate new scientific issues related to global environmental change and the related resilience issues, especially those of transdisciplinary nature and of major relevance to society; 3. To explore new approaches towards truly integrated, interdisciplinary science, and to facilitate the 'revolution' in education and capacity building it requires. The work of RESCUE focused on the following themes: · Contributions from social sciences and humanities in developing responses to challenges of the Anthropocene; · Collaboration between the natural, social and human sciences in global environmental change and resilience studies; · Requirements for research methodologies and data; · Education and capacity building - towards a 'revolution'; · The interface between science and policy, communication and outreach. The RESCUE recommendations include the following issues to be addressed by science-funders, science policy-makers, researchers, practitioners, educators and a range of other societal actors: · develop an institutional framework for an open knowledge society, · re-organise research so

  20. The Numerical Tokamak Project (NTP) simulation of turbulent transport in the core plasma: A grand challenge in plasma physics

    International Nuclear Information System (INIS)

    1993-12-01

    The long-range goal of the Numerical Tokamak Project (NTP) is the reliable prediction of tokamak performance using physics-based numerical tools describing tokamak physics. The NTP is accomplishing the development of the most advanced particle and extended fluid model's on massively parallel processing (MPP) environments as part of a multi-institutional, multi-disciplinary numerical study of tokamak core fluctuations. The NTP is a continuing focus of the Office of Fusion Energy's theory and computation program. Near-term HPCC work concentrates on developing a predictive numerical description of the core plasma transport in tokamaks driven by low-frequency collective fluctuations. This work addresses one of the greatest intellectual challenges to our understanding of the physics of tokamak performance and needs the most advanced computational resources to progress. We are conducting detailed comparisons of kinetic and fluid numerical models of tokamak turbulence. These comparisons are stimulating the improvement of each and the development of hybrid models which embody aspects of both. The combination of emerging massively parallel processing hardware and algorithmic improvements will result in an estimated 10**2--10**6 performance increase. Development of information processing and visualization tools is accelerating our comparison of computational models to one another, to experimental data, and to analytical theory, providing a bootstrap effect in our understanding of the target physics. The measure of success is the degree to which the experimentally observed scaling of fluctuation-driven transport may be predicted numerically. The NTP is advancing the HPCC Initiative through its state-of-the-art computational work. We are pushing the capability of high performance computing through our efforts which are strongly leveraged by OFE support

  1. Binding affinities of the farnesoid X receptor in the D3R Grand Challenge 2 estimated by free-energy perturbation and docking

    Science.gov (United States)

    Olsson, Martin A.; García-Sosa, Alfonso T.; Ryde, Ulf

    2018-01-01

    We have studied the binding of 102 ligands to the farnesoid X receptor within the D3R Grand Challenge 2016 blind-prediction competition. First, we employed docking with five different docking software and scoring functions. The selected docked poses gave an average root-mean-squared deviation of 4.2 Å. Consensus scoring gave decent results with a Kendall's τ of 0.26 ± 0.06 and a Spearman's ρ of 0.41 ± 0.08. For a subset of 33 ligands, we calculated relative binding free energies with free-energy perturbation. Five transformations between the ligands involved a change of the net charge and we implemented and benchmarked a semi-analytic correction (Rocklin et al., J Chem Phys 139:184103, 2013) for artifacts caused by the periodic boundary conditions and Ewald summation. The results gave a mean absolute deviation of 7.5 kJ/mol compared to the experimental estimates and a correlation coefficient of R 2 = 0.1. These results were among the four best in this competition out of 22 submissions. The charge corrections were significant (7-8 kJ/mol) and always improved the results. By employing 23 intermediate states in the free-energy perturbation, there was a proper overlap between all states and the precision was 0.1-0.7 kJ/mol. However, thermodynamic cycles indicate that the sampling was insufficient in some of the perturbations.

  2. Improving binding mode and binding affinity predictions of docking by ligand-based search of protein conformations: evaluation in D3R grand challenge 2015

    Science.gov (United States)

    Xu, Xianjin; Yan, Chengfei; Zou, Xiaoqin

    2017-08-01

    The growing number of protein-ligand complex structures, particularly the structures of proteins co-bound with different ligands, in the Protein Data Bank helps us tackle two major challenges in molecular docking studies: the protein flexibility and the scoring function. Here, we introduced a systematic strategy by using the information embedded in the known protein-ligand complex structures to improve both binding mode and binding affinity predictions. Specifically, a ligand similarity calculation method was employed to search a receptor structure with a bound ligand sharing high similarity with the query ligand for the docking use. The strategy was applied to the two datasets (HSP90 and MAP4K4) in recent D3R Grand Challenge 2015. In addition, for the HSP90 dataset, a system-specific scoring function (ITScore2_hsp90) was generated by recalibrating our statistical potential-based scoring function (ITScore2) using the known protein-ligand complex structures and the statistical mechanics-based iterative method. For the HSP90 dataset, better performances were achieved for both binding mode and binding affinity predictions comparing with the original ITScore2 and with ensemble docking. For the MAP4K4 dataset, although there were only eight known protein-ligand complex structures, our docking strategy achieved a comparable performance with ensemble docking. Our method for receptor conformational selection and iterative method for the development of system-specific statistical potential-based scoring functions can be easily applied to other protein targets that have a number of protein-ligand complex structures available to improve predictions on binding.

  3. Predicting binding poses and affinities for protein - ligand complexes in the 2015 D3R Grand Challenge using a physical model with a statistical parameter estimation

    Science.gov (United States)

    Grudinin, Sergei; Kadukova, Maria; Eisenbarth, Andreas; Marillet, Simon; Cazals, Frédéric

    2016-09-01

    The 2015 D3R Grand Challenge provided an opportunity to test our new model for the binding free energy of small molecules, as well as to assess our protocol to predict binding poses for protein-ligand complexes. Our pose predictions were ranked 3-9 for the HSP90 dataset, depending on the assessment metric. For the MAP4K dataset the ranks are very dispersed and equal to 2-35, depending on the assessment metric, which does not provide any insight into the accuracy of the method. The main success of our pose prediction protocol was the re-scoring stage using the recently developed Convex-PL potential. We make a thorough analysis of our docking predictions made with AutoDock Vina and discuss the effect of the choice of rigid receptor templates, the number of flexible residues in the binding pocket, the binding pocket size, and the benefits of re-scoring. However, the main challenge was to predict experimentally determined binding affinities for two blind test sets. Our affinity prediction model consisted of two terms, a pairwise-additive enthalpy, and a non pairwise-additive entropy. We trained the free parameters of the model with a regularized regression using affinity and structural data from the PDBBind database. Our model performed very well on the training set, however, failed on the two test sets. We explain the drawback and pitfalls of our model, in particular in terms of relative coverage of the test set by the training set and missed dynamical properties from crystal structures, and discuss different routes to improve it.

  4. Grandes cocinas

    Directory of Open Access Journals (Sweden)

    García de Castro, Emilio

    1957-11-01

    Full Text Available Se describen en este artículo una serie de aparatos para grandes cocinas, vistos por los autores durante un rápido viaje por Alemania. Aprovechando los datos obtenidos se analizan brevemente las necesidades de una gran cocina moderna, comentando los planos de las instalaciones en varios hoteles o instituciones de todo el mundo. La mayoría de la información.

  5. Electronic word of mouth: Challenges for consumers and companies

    NARCIS (Netherlands)

    Willemsen, L.M.

    2013-01-01

    It is well-established that, as a consumer decision aid, electronic word of mouth (eWOM) provides opportunities to both consumers and companies. By relying on eWOM, consumers believe that they are better able to make informed purchase decisions. By incorporating eWOM in their business strategies,

  6. Big Data and Grand Challenges

    DEFF Research Database (Denmark)

    Finnemann, Niels Ole

    2016-01-01

    The paper discusses the future of the Humanities and the role of Digital Humanities. Taking the point of departure in Rens Bods “A new History of the humanities” (2013) it is argued that the current crisis within the Humanities and Digital Humanities is not as much about different notions of cult...

  7. Grand challenges for crop science

    Science.gov (United States)

    Crop science is a highly integrative science using the disciplines of conventional plant breeding, transgenic crop improvement, plant physiology, and cropping system sciences to develop improved varieties of agronomic, turf, and forage crops to produce feed, food, fuel, and fiber for our world's gro...

  8. The Assurance Challenges of Advanced Packaging Technologies for Electronics

    Science.gov (United States)

    Sampson, Michael J.

    2010-01-01

    Advances in microelectronic parts performance are driving towards finer feature sizes, three-dimensional geometries and ever-increasing number of transistor equivalents that are resulting in increased die sizes and interconnection (I/O) counts. The resultant packaging necessary to provide assemble-ability, environmental protection, testability and interconnection to the circuit board for the active die creates major challenges, particularly for space applications, Traditionally, NASA has used hermetically packaged microcircuits whenever available but the new demands make hermetic packaging less and less practical at the same time as more and more expensive, Some part types of great interest to NASA designers are currently only available in non-hermetic packaging. It is a far more complex quality and reliability assurance challenge to gain confidence in the long-term survivability and effectiveness of nonhermetic packages than for hermetic ones. Although they may provide more rugged environmental protection than the familiar Plastic Encapsulated Microcircuits (PEMs), the non-hermetic Ceramic Column Grid Array (CCGA) packages that are the focus of this presentation present a unique combination of challenges to assessing their suitability for spaceflight use. The presentation will discuss the bases for these challenges, some examples of the techniques proposed to mitigate them and a proposed approach to a US MIL specification Class for non-hermetic microcircuits suitable for space application, Class Y, to be incorporated into M. IL-PRF-38535. It has recently emerged that some major packaging suppliers are offering hermetic area array packages that may offer alternatives to the nonhermetic CCGA styles but have also got their own inspectability and testability issues which will be briefly discussed in the presentation,

  9. Leveraging this Golden Age of Remote Sensing and Modeling of Terrestrial Hydrology to Understand Water Cycling in the Water Availability Grand Challenge for North America

    Science.gov (United States)

    Painter, T. H.; Famiglietti, J. S.; Stephens, G. L.

    2016-12-01

    We live in a time of increasing strains on our global fresh water availability due to increasing population, warming climate, changes in precipitation, and extensive depletion of groundwater supplies. At the same time, we have seen enormous growth in capabilities to remotely sense the regional to global water cycle and model complex systems with physically based frameworks. The GEWEX Water Availability Grand Challenge for North America is poised to leverage this convergence of remote sensing and modeling capabilities to answer fundamental questions on the water cycle. In particular, we envision an experiment that targets the complex and resource-critical Western US from California to just into the Great Plains, constraining physically-based hydrologic modeling with the US and international remote sensing capabilities. In particular, the last decade has seen the implementation or soon-to-be launch of water cycle missions such as GRACE and GRACE-FO for groundwater, SMAP for soil moisture, GPM for precipitation, SWOT for terrestrial surface water, and the Airborne Snow Observatory for snowpack. With the advent of convection-resolving mesoscale climate and water cycle modeling (e.g. WRF, WRF-Hydro) and mesoscale models capable of quantitative assimilation of remotely sensed data (e.g. the JPL Western States Water Mission), we can now begin to test hypotheses on the nature and changes in the water cycle of the Western US from a physical standpoint. In turn, by fusing water cycle science, water management, and ecosystem management while addressing these hypotheses, this golden age of remote sensing and modeling can bring all fields into a markedly less uncertain state of present knowledge and decadal scale forecasts.

  10. Challenges in validating radiation sterilization with low energy electron irradiation

    International Nuclear Information System (INIS)

    Miller, A.; Helt-Hansen, J.

    2011-01-01

    Complete text of publication follows. Low energy electron irradiation (80-300 keV) is used increasingly for sterilization or decontamination in connection with isolators for aseptic filling lines in the pharmaceutical industry. It is not defined how validation for this process shall be carried out. A method can be derived from the medical device standard for radiation sterilization, ISO 11137, because the principles described in this standard can be applied to almost any industrial irradiation process. The validations elements are: Process definition, concerning specification of the dose required for the process and the maximum acceptable dose for the product. Installation qualification, concerning acceptance the irradiation facility. Operational qualification, concerning characterization of the facility. Performance qualification, concerning setting up the process. Process control, concerning routine monitoring. The limited penetration of the low energy electrons leads to problems with respect to executing these validation steps. This paper discusses these problems, and shows with examples how they can be solved.

  11. E-FULFILLMENT - A NEW CHALLENGE FOR ELECTRONIC BUSINESS

    Directory of Open Access Journals (Sweden)

    CLAUDIA ISAC

    2014-10-01

    Full Text Available Currently, we are witnessing a uniform interconnect solutions that allow easier access of small businesses and start-ups to electronic commerce and even their unprecedented development using specialized intermediaries. Thus, a modern distribution system is the e-Fulfillment presented in this paper. In the first part of the paper by presenting the concept and technological developments we have highlighted several classifications thereof. The biggest part presents the main operations are conducted at the operator e-Fulfillment, from taking products from suppliers, management, logistics information needed to store transactions through electronic transfer of goods to customers using courier companies, settlement and billing services, forms of promotion etc. The paper ends with some aspects of the advantages of using these systems, the costs involved and examples for Romania.

  12. Large-Area, Ensemble Molecular Electronics: Motivation and Challenges.

    Science.gov (United States)

    Vilan, Ayelet; Aswal, Dinesh; Cahen, David

    2017-03-08

    We review charge transport across molecular monolayers, which is central to molecular electronics (MolEl), using large-area junctions (NmJ). We strive to provide a wide conceptual overview of three main subtopics. First, a broad introduction places NmJ in perspective to related fields of research and to single-molecule junctions (1mJ) in addition to a brief historical account. As charge transport presents an ultrasensitive probe for the electronic perfection of interfaces, in the second part ways to form both the monolayer and the contacts are described to construct reliable, defect-free interfaces. The last part is dedicated to understanding and analyses of current-voltage (I-V) traces across molecular junctions. Notwithstanding the original motivation of MolEl, I-V traces are often not very sensitive to molecular details and then provide a poor probe for chemical information. Instead, we focus on how to analyze the net electrical performance of molecular junctions, from a functional device perspective. Finally, we point to creation of a built-in electric field as a key to achieve functionality, including nonlinear current-voltage characteristics that originate in the molecules or their contacts to the electrodes. This review is complemented by a another review that covers metal-molecule-semiconductor junctions and their unique hybrid effects.

  13. Efect of intercellular extracts from banana inoculated leaves with Mycosphaerella fijiensis Morelet, on chloroplast electronic transport of Grande naine (AAA cv.

    Directory of Open Access Journals (Sweden)

    Michel Leiva-Mora

    2003-01-01

    Full Text Available Some foliar pathogens colonize intercellular spaces of damage tissues during infection process, mediated by toxins production and diffusion to kill adjacent healthy cells. Due to the absence of reliable bioassays, the physiologic effects of several phytotoxins are still ignored on cellular membranous systems of the affected cells. In the present work it was extracted the intercellular content from not inoculated and inoculated banana leaves with different Mycosphaerella fijiensis strains. Their effects on chloroplasts of Grande naine cv were evaluated by the absorbance evolution (595 nm of Hill reactive (DCPIP, mixture with 810 ì l of chloroplasts suspension and 99 ì l of the intercellular contents. The electronic exchange on chloroplasts suspension was inhibited by intercellular contents of inoculated leaves. The intercellular contents from leaves inoculated with I1 (high virulence strain had a major inhibiter effect respect to leaves inoculates with G1 strain (low virulence, showing a correspondence between the inhibiter effect of intercellular contents and the affection levels of affected tissues. The procedures used in this work will let to make studies concerned with Mycosphaerella fijiensis-Musa spp interactions and the future breeding programs. Key words: banana breeding, black Sigatoka, host pathogen interaction, physiological bioassays

  14. The Challenges of Electronic Health Records and Diabetes Electronic Prescribing: Implications for Safety Net Care for Diverse Populations

    Directory of Open Access Journals (Sweden)

    Neda Ratanawongsa

    2017-01-01

    Full Text Available Widespread electronic health record (EHR implementation creates new challenges in the diabetes care of complex and diverse populations, including safe medication prescribing for patients with limited health literacy and limited English proficiency. This review highlights how the EHR electronic prescribing transformation has affected diabetes care for vulnerable patients and offers recommendations for improving patient safety through EHR electronic prescribing design, implementation, policy, and research. Specifically, we present evidence for (1 the adoption of RxNorm; (2 standardized naming and picklist options for high alert medications such as insulin; (3 the widespread implementation of universal medication schedule and language-concordant labels, with the expansion of electronic prescription 140-character limit; (4 enhanced bidirectional communication with pharmacy partners; and (5 informatics and implementation research in safety net healthcare systems to examine how EHR tools and practices affect diverse vulnerable populations.

  15. Using the Electronic Health Record in Nursing Research: Challenges and Opportunities.

    Science.gov (United States)

    Samuels, Joanne G; McGrath, Robert J; Fetzer, Susan J; Mittal, Prashant; Bourgoine, Derek

    2015-10-01

    Changes in the patient record from the paper to the electronic health record format present challenges and opportunities for the nurse researcher. Current use of data from the electronic health record is in a state of flux. Novel data analytic techniques and massive data sets provide new opportunities for nursing science. Realization of a strong electronic data output future relies on meeting challenges of system use and operability, data presentation, and privacy. Nurse researchers need to rethink aspects of proposal development. Joining ongoing national efforts aimed at creating usable data output is encouraged as a means to affect system design. Working to address challenges and embrace opportunities will help grow the science in a way that answers important patient care questions. © The Author(s) 2015.

  16. Power electronics and electric machinery challenges and opportunities in electric and hybrid vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Adams, D.J.; Hsu, J.S.; Young, R.W. [Oak Ridge National Lab., TN (United States); Peng, F.Z. [Univ. of Tennessee, Knoxville, TN (United States)

    1997-06-01

    The development of power electronics and electric machinery presents significant challenges to the advancement of electric and hybrid vehicles. Electronic components and systems development for vehicle applications have progressed from the replacement of mechanical systems to the availability of features that can only be realized through interacting electronic controls and devices. Near-term applications of power electronics in vehicles will enable integrated powertrain controls, integrated chassis system controls, and navigation and communications systems. Future applications of optimized electric machinery will enable highly efficient and lightweight systems. This paper will explore the areas where research and development is required to ensure the continued development of power electronics and electric machines to meet the rigorous demands of automotive applications. Additionally, recent advances in automotive related power electronics and electric machinery at Oak Ridge National Laboratory will be explained. 3 refs., 5 figs.

  17. Using Linked Electronic Health Records to Estimate Healthcare Costs: Key Challenges and Opportunities.

    Science.gov (United States)

    Asaria, Miqdad; Grasic, Katja; Walker, Simon

    2016-02-01

    This paper discusses key challenges and opportunities that arise when using linked electronic health records (EHR) in health economics and outcomes research (HEOR), with a particular focus on estimating healthcare costs. These challenges and opportunities are framed in the context of a case study modelling the costs of stable coronary artery disease in England. The challenges and opportunities discussed fall broadly into the categories of (1) handling and organising data of this size and sensitivity; (2) extracting clinical endpoints from datasets that have not been designed and collected with such endpoints in mind; and (3) the principles and practice of costing resource use from routinely collected data. We find that there are a number of new challenges and opportunities that arise when working with EHR compared with more traditional sources of data for HEOR. These call for greater clinician involvement and intelligent use of sensitivity analysis.

  18. Challenges with Electrical, Electronics, and Electromechanical Parts for James Webb Space Telescope

    Science.gov (United States)

    Jah, Muzar A.; Jeffers, Basil S.

    2016-01-01

    James Webb Space Telescope (JWST) is the space-based observatory that will extend the knowledge gained by the Hubble Space Telescope (HST). Hubble focuses on optical and ultraviolet wavelengths while JWST focuses on the infrared portion of the electromagnetic spectrum, to see the earliest stars and galaxies that formed in the Universe and to look deep into nearby dust clouds to study the formation of stars and planets. JWST, which commenced creation in 1996, is scheduled to launch in 2018. It includes a suite of four instruments, the spacecraft bus, optical telescope element, Integrated Science Instrument Module (ISIM, the platform to hold the instruments), and a sunshield. The mass of JWST is approximately 6200 kg, including observatory, on-orbit consumables and launch vehicle adaptor. Many challenges were overcome while providing the electrical and electronic components for the Goddard Space Flight Center hardware builds. Other difficulties encountered included developing components to work at cryogenic temperatures, failures of electronic components during development and flight builds, Integration and Test electronic parts problems, and managing technical issues with international partners. This paper will present the context of JWST from a EEE (electrical, electronic, and electromechanical) perspective with examples of challenges and lessons learned throughout the design, development, and fabrication of JWST in cooperation with our associated partners including the Canadian Space Agency (CSA), the European Space Agency (ESA), Lockheed Martin and their respective associated partners. Technical challenges and lessons learned will be discussed.

  19. Current status and future perspectives of electron interactions with molecules, clusters, surfaces, and interfaces [Workshop on Fundamental challenges in electron-driven chemistry; Workshop on Electron-driven processes: Scientific challenges and technological opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Kurt H.; McCurdy, C. William; Orlando, Thomas M.; Rescigno, Thomas N.

    2000-09-01

    This report is based largely on presentations and discussions at two workshops and contributions from workshop participants. The workshop on Fundamental Challenges in Electron-Driven Chemistry was held in Berkeley, October 9-10, 1998, and addressed questions regarding theory, computation, and simulation. The workshop on Electron-Driven Processes: Scientific Challenges and Technological Opportunities was held at Stevens Institute of Technology, March 16-17, 2000, and focused largely on experiments. Electron-molecule and electron-atom collisions initiate and drive almost all the relevant chemical processes associated with radiation chemistry, environmental chemistry, stability of waste repositories, plasma-enhanced chemical vapor deposition, plasma processing of materials for microelectronic devices and other applications, and novel light sources for research purposes (e.g. excimer lamps in the extreme ultraviolet) and in everyday lighting applications. The life sciences are a rapidly advancing field where the important role of electron-driven processes is only now beginning to be recognized. Many of the applications of electron-initiated chemical processes require results in the near term. A large-scale, multidisciplinary and collaborative effort should be mounted to solve these problems in a timely way so that their solution will have the needed impact on the urgent questions of understanding the physico-chemical processes initiated and driven by electron interactions.

  20. Challenges in Waste Electrical and Electronic Equipment Management: A Profitability Assessment in Three European Countries

    Directory of Open Access Journals (Sweden)

    Idiano D’Adamo

    2016-07-01

    Full Text Available Waste electrical and electronic equipment (WEEE is known as an important source of secondary raw materials. Since decades, its treatment allowed to recover great amounts of basic resources. However, the management of electronic components embedded in WEEE still presents many challenges. The purpose of the paper is to cope with some of these challenges through the definition of an economic model able to identify the presence of profitability within the recovery process of waste printed circuit boards (WPCBs. To this aim, a set of common economic indexes is used within the paper. Furthermore, a sensitivity analysis on a set of critical variables is conducted to evaluate their impact on the results. Finally, the combination of predicted WEEE volumes (collected during the 2015–2030 period in three European countries (Germany, Italy and the United Kingdom and related economic indexes quantify the potential advantage coming from the recovery of this kind of waste in the next future.

  1. Young-type interferences with electrons basics and theoretical challenges in molecular collision systems

    CERN Document Server

    Frémont, François

    2014-01-01

    Since the discovery that atomic-size particles can be described as waves, many interference experiments have been realized with electrons to demonstrate their wave behavior. In this book, after describing the different steps that led to the present knowledge, we focus on the strong link existing between photon and electron interferences, highlighting the similarities and the differences. For example, the atomic centers of a hydrogen molecule are used to mimic the slits in the Young's famous interference experiment with light. We show, however, that the basic time-dependent ionization theories that describe these Young-type electron interferences are not able to reproduce the experiment. This crucial point remains a real challenge for theoreticians in atomic collision physics.

  2. Using physics-based pose predictions and free energy perturbation calculations to predict binding poses and relative binding affinities for FXR ligands in the D3R Grand Challenge 2

    Science.gov (United States)

    Athanasiou, Christina; Vasilakaki, Sofia; Dellis, Dimitris; Cournia, Zoe

    2018-01-01

    Computer-aided drug design has become an integral part of drug discovery and development in the pharmaceutical and biotechnology industry, and is nowadays extensively used in the lead identification and lead optimization phases. The drug design data resource (D3R) organizes challenges against blinded experimental data to prospectively test computational methodologies as an opportunity for improved methods and algorithms to emerge. We participated in Grand Challenge 2 to predict the crystallographic poses of 36 Farnesoid X Receptor (FXR)-bound ligands and the relative binding affinities for two designated subsets of 18 and 15 FXR-bound ligands. Here, we present our methodology for pose and affinity predictions and its evaluation after the release of the experimental data. For predicting the crystallographic poses, we used docking and physics-based pose prediction methods guided by the binding poses of native ligands. For FXR ligands with known chemotypes in the PDB, we accurately predicted their binding modes, while for those with unknown chemotypes the predictions were more challenging. Our group ranked #1st (based on the median RMSD) out of 46 groups, which submitted complete entries for the binding pose prediction challenge. For the relative binding affinity prediction challenge, we performed free energy perturbation (FEP) calculations coupled with molecular dynamics (MD) simulations. FEP/MD calculations displayed a high success rate in identifying compounds with better or worse binding affinity than the reference (parent) compound. Our studies suggest that when ligands with chemical precedent are available in the literature, binding pose predictions using docking and physics-based methods are reliable; however, predictions are challenging for ligands with completely unknown chemotypes. We also show that FEP/MD calculations hold predictive value and can nowadays be used in a high throughput mode in a lead optimization project provided that crystal structures of

  3. Grand Challenges in School Social Work: Collaboration and Constraint in School Social Workers' Sexuality Support for Children with Disabilities

    Science.gov (United States)

    Bolin, Sharon J.; Rueda, Heidi Adams; Linton, Kristen F.

    2018-01-01

    Children with disabilities (CWD) face challenges to the development of their sexuality, in part due to a lack of appropriate, tailored sexual education in schools, role ambiguity regarding provision of sexual health services, and widespread discomfort with the topic. However, CWD have unique sexual health needs, an increased vulnerability to…

  4. Electronic health records approaches and challenges: a comparison between Malaysia and four East Asian countries.

    Science.gov (United States)

    Abd Ghani, Mohd Khanapi; Bali, Rajeev K; Naguib, Raouf N G; Marshall, Ian M

    2008-01-01

    An integrated Lifetime Health Record (LHR) is fundamental for achieving seamless and continuous access to patient medical information and for the continuum of care. However, the aim has not yet been fully realised. The efforts are actively progressing around the globe. Every stage of the development of the LHR initiatives had presented peculiar challenges. The best lessons in life are those of someone else's experiences. This paper presents an overview of the development approaches undertaken by four East Asian countries in implementing a national Electronic Health Record (EHR) in the public health system. The major challenges elicited from the review including integration efforts, process reengineering, funding, people, and law and regulation will be presented, compared, discussed and used as lessons learned for the further development of the Malaysian integrated LHR.

  5. Electronic commerce, automation and online banking in Nigeria: challenges and benefits

    Directory of Open Access Journals (Sweden)

    B. Sc., M. Sc. Stephen A. Ojeka

    2011-05-01

    Full Text Available Electronic banking has been around for some time in the form of automatic teller machines and telephone transactions. More recently, it has been metamorphosed by the Internet; a new look and delivery channel for banking services that benefits both customers and banks. The objective of this paper is to find out the correlation between the anticipated benefits/challenges and encountered benefits/challenges. This paper therefore empirically, adopted the use of survey research to explore in quantitative terms the various challenges and benefits e-business poses to Nigeria businesses, with particular reference to Banking and Finance Industry. It was found out that there is statistically significant difference between the anticipated and encountered benefits and major challenge is the security breach faced the customers. We therefore recommend that workshops should be organized for customers periodically on how to keep their data secret especially on how to combine numbers to form password and Constant training of employees both local and international on new development in online trading should be encouraged.

  6. An introduction to electronic learning and its use to address challenges in surgical training.

    Science.gov (United States)

    Baran, Szczepan W; Johnson, Elizabeth J; Kehler, James

    2009-06-01

    The animal research community faces a shortage of surgical training opportunities along with an increasing demand for expertise in surgical techniques. One possible means of overcoming this challenge is the use of computer-based or electronic learning (e-learning) to disseminate material to a broad range of animal users. E-learning platforms can take many different forms, ranging from simple text documents that are posted online to complex virtual courses that incorporate dynamic video or audio content and in which students and instructors can interact in real time. The authors present an overview of e-learning and discuss its potential benefits as a supplement to hands-on rodent surgical training. They also discuss a few basic considerations in developing and implementing electronic courses.

  7. Process qualification and control in electron beams--requirements, methods, new concepts and challenges

    International Nuclear Information System (INIS)

    Mittendorfer, J.; Gratzl, F.; Hanis, D.

    2004-01-01

    In this paper the status of process qualification and control in electron beam irradiation is analyzed in terms of requirements, concepts, methods and challenges for a state-of-the-art process control concept for medical device sterilization. Aspects from process qualification to routine process control are described together with the associated process variables. As a case study the 10 MeV beams at Mediscan GmbH are considered. Process control concepts like statistical process control (SPC) and a new concept to determine process capability is briefly discussed

  8. Deployment of German Electronic Citizen Cards in Banking: Opportunities and Challenges

    Science.gov (United States)

    Büger, Matthias

    The German federal government plans to issue an electronic citizen card (eID) in 2009, replacing the current identity card (Personalausweis). Since the eID should be good for identification in E-government as well as E-business applications, it is aimed to be used in the banking environment. One application would be opening a bank account in the internet. If this was possible, the process would be much easier than today. However, German law still requires a physical ID card. We will discuss the opportunities and the challenges of possible usage of eID in banking.

  9. Ranking docking poses by graph matching of protein-ligand interactions: lessons learned from the D3R Grand Challenge 2

    Science.gov (United States)

    da Silva Figueiredo Celestino Gomes, Priscila; Da Silva, Franck; Bret, Guillaume; Rognan, Didier

    2018-01-01

    A novel docking challenge has been set by the Drug Design Data Resource (D3R) in order to predict the pose and affinity ranking of a set of Farnesoid X receptor (FXR) agonists, prior to the public release of their bound X-ray structures and potencies. In a first phase, 36 agonists were docked to 26 Protein Data Bank (PDB) structures of the FXR receptor, and next rescored using the in-house developed GRIM method. GRIM aligns protein-ligand interaction patterns of docked poses to those of available PDB templates for the target protein, and rescore poses by a graph matching method. In agreement with results obtained during the previous 2015 docking challenge, we clearly show that GRIM rescoring improves the overall quality of top-ranked poses by prioritizing interaction patterns already visited in the PDB. Importantly, this challenge enables us to refine the applicability domain of the method by better defining the conditions of its success. We notably show that rescoring apolar ligands in hydrophobic pockets leads to frequent GRIM failures. In the second phase, 102 FXR agonists were ranked by decreasing affinity according to the Gibbs free energy of the corresponding GRIM-selected poses, computed by the HYDE scoring function. Interestingly, this fast and simple rescoring scheme provided the third most accurate ranking method among 57 contributions. Although the obtained ranking is still unsuitable for hit to lead optimization, the GRIM-HYDE scoring scheme is accurate and fast enough to post-process virtual screening data.

  10. Practice Facilitator Strategies for Addressing Electronic Health Record Data Challenges for Quality Improvement: EvidenceNOW.

    Science.gov (United States)

    Hemler, Jennifer R; Hall, Jennifer D; Cholan, Raja A; Crabtree, Benjamin F; Damschroder, Laura J; Solberg, Leif I; Ono, Sarah S; Cohen, Deborah J

    2018-01-01

    Practice facilitators ("facilitators") can play an important role in supporting primary care practices in performing quality improvement (QI), but they need complete and accurate clinical performance data from practices' electronic health records (EHR) to help them set improvement priorities, guide clinical change, and monitor progress. Here, we describe the strategies facilitators use to help practices perform QI when complete or accurate performance data are not available. Seven regional cooperatives enrolled approximately 1500 small-to-medium-sized primary care practices and 136 facilitators in EvidenceNOW, the Agency for Healthcare Research and Quality's initiative to improve cardiovascular preventive services. The national evaluation team analyzed qualitative data from online diaries, site visit field notes, and interviews to discover how facilitators worked with practices on EHR data challenges to obtain and use data for QI. We found facilitators faced practice-level EHR data challenges, such as a lack of clinical performance data, partial or incomplete clinical performance data, and inaccurate clinical performance data. We found that facilitators responded to these challenges, respectively, by using other data sources or tools to fill in for missing data, approximating performance reports and generating patient lists, and teaching practices how to document care and confirm performance measures. In addition, facilitators helped practices communicate with EHR vendors or health systems in requesting data they needed. Overall, facilitators tailored strategies to fit the individual practice and helped build data skills and trust. Facilitators can use a range of strategies to help practices perform data-driven QI when performance data are inaccurate, incomplete, or missing. Support is necessary to help practices, particularly those with EHR data challenges, build their capacity for conducting data-driven QI that is required of them for participating in practice

  11. Binding free energy predictions of farnesoid X receptor (FXR) agonists using a linear interaction energy (LIE) approach with reliability estimation: application to the D3R Grand Challenge 2

    Science.gov (United States)

    Rifai, Eko Aditya; van Dijk, Marc; Vermeulen, Nico P. E.; Geerke, Daan P.

    2018-01-01

    Computational protein binding affinity prediction can play an important role in drug research but performing efficient and accurate binding free energy calculations is still challenging. In the context of phase 2 of the Drug Design Data Resource (D3R) Grand Challenge 2 we used our automated eTOX ALLIES approach to apply the (iterative) linear interaction energy (LIE) method and we evaluated its performance in predicting binding affinities for farnesoid X receptor (FXR) agonists. Efficiency was obtained by our pre-calibrated LIE models and molecular dynamics (MD) simulations at the nanosecond scale, while predictive accuracy was obtained for a small subset of compounds. Using our recently introduced reliability estimation metrics, we could classify predictions with higher confidence by featuring an applicability domain (AD) analysis in combination with protein-ligand interaction profiling. The outcomes of and agreement between our AD and interaction-profile analyses to distinguish and rationalize the performance of our predictions highlighted the relevance of sufficiently exploring protein-ligand interactions during training and it demonstrated the possibility to quantitatively and efficiently evaluate if this is achieved by using simulation data only.

  12. Focus: Two-dimensional electron-electron double resonance and molecular motions: The challenge of higher frequencies

    Energy Technology Data Exchange (ETDEWEB)

    Franck, John M.; Chandrasekaran, Siddarth; Dzikovski, Boris; Dunnam, Curt R.; Freed, Jack H., E-mail: jhf3@cornell.edu [Department of Chemistry and Chemical Biology and National Biomedical Center for Advanced ESR Technology, Cornell University, Ithaca, New York 14853 (United States)

    2015-06-07

    The development, applications, and current challenges of the pulsed ESR technique of two-dimensional Electron-Electron Double Resonance (2D ELDOR) are described. This is a three-pulse technique akin to 2D Exchange Nuclear Magnetic Resonance, but involving electron spins, usually in the form of spin-probes or spin-labels. As a result, it required the extension to much higher frequencies, i.e., microwaves, and much faster time scales, with π/2 pulses in the 2-3 ns range. It has proven very useful for studying molecular dynamics in complex fluids, and spectral results can be explained by fitting theoretical models (also described) that provide a detailed analysis of the molecular dynamics and structure. We discuss concepts that also appear in other forms of 2D spectroscopy but emphasize the unique advantages and difficulties that are intrinsic to ESR. Advantages include the ability to tune the resonance frequency, in order to probe different motional ranges, while challenges include the high ratio of the detection dead time vs. the relaxation times. We review several important 2D ELDOR studies of molecular dynamics. (1) The results from a spin probe dissolved in a liquid crystal are followed throughout the isotropic → nematic → liquid-like smectic → solid-like smectic → crystalline phases as the temperature is reduced and are interpreted in terms of the slowly relaxing local structure model. Here, the labeled molecule is undergoing overall motion in the macroscopically aligned sample, as well as responding to local site fluctuations. (2) Several examples involving model phospholipid membranes are provided, including the dynamic structural characterization of the boundary lipid that coats a transmembrane peptide dimer. Additionally, subtle differences can be elicited for the phospholipid membrane phases: liquid disordered, liquid ordered, and gel, and the subtle effects upon the membrane, of antigen cross-linking of receptors on the surface of plasma membrane

  13. Focus: Two-dimensional electron-electron double resonance and molecular motions: The challenge of higher frequencies

    International Nuclear Information System (INIS)

    Franck, John M.; Chandrasekaran, Siddarth; Dzikovski, Boris; Dunnam, Curt R.; Freed, Jack H.

    2015-01-01

    The development, applications, and current challenges of the pulsed ESR technique of two-dimensional Electron-Electron Double Resonance (2D ELDOR) are described. This is a three-pulse technique akin to 2D Exchange Nuclear Magnetic Resonance, but involving electron spins, usually in the form of spin-probes or spin-labels. As a result, it required the extension to much higher frequencies, i.e., microwaves, and much faster time scales, with π/2 pulses in the 2-3 ns range. It has proven very useful for studying molecular dynamics in complex fluids, and spectral results can be explained by fitting theoretical models (also described) that provide a detailed analysis of the molecular dynamics and structure. We discuss concepts that also appear in other forms of 2D spectroscopy but emphasize the unique advantages and difficulties that are intrinsic to ESR. Advantages include the ability to tune the resonance frequency, in order to probe different motional ranges, while challenges include the high ratio of the detection dead time vs. the relaxation times. We review several important 2D ELDOR studies of molecular dynamics. (1) The results from a spin probe dissolved in a liquid crystal are followed throughout the isotropic → nematic → liquid-like smectic → solid-like smectic → crystalline phases as the temperature is reduced and are interpreted in terms of the slowly relaxing local structure model. Here, the labeled molecule is undergoing overall motion in the macroscopically aligned sample, as well as responding to local site fluctuations. (2) Several examples involving model phospholipid membranes are provided, including the dynamic structural characterization of the boundary lipid that coats a transmembrane peptide dimer. Additionally, subtle differences can be elicited for the phospholipid membrane phases: liquid disordered, liquid ordered, and gel, and the subtle effects upon the membrane, of antigen cross-linking of receptors on the surface of plasma membrane

  14. Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework to Address Challenges.

    Science.gov (United States)

    Amarasingham, Ruben; Audet, Anne-Marie J; Bates, David W; Glenn Cohen, I; Entwistle, Martin; Escobar, G J; Liu, Vincent; Etheredge, Lynn; Lo, Bernard; Ohno-Machado, Lucila; Ram, Sudha; Saria, Suchi; Schilling, Lisa M; Shahi, Anand; Stewart, Walter F; Steyerberg, Ewout W; Xie, Bin

    2016-01-01

    The recent explosion in available electronic health record (EHR) data is motivating a rapid expansion of electronic health care predictive analytic (e-HPA) applications, defined as the use of electronic algorithms that forecast clinical events in real time with the intent to improve patient outcomes and reduce costs. There is an urgent need for a systematic framework to guide the development and application of e-HPA to ensure that the field develops in a scientifically sound, ethical, and efficient manner. Building upon earlier frameworks of model development and utilization, we identify the emerging opportunities and challenges of e-HPA, propose a framework that enables us to realize these opportunities, address these challenges, and motivate e-HPA stakeholders to both adopt and continuously refine the framework as the applications of e-HPA emerge. To achieve these objectives, 17 experts with diverse expertise including methodology, ethics, legal, regulation, and health care delivery systems were assembled to identify emerging opportunities and challenges of e-HPA and to propose a framework to guide the development and application of e-HPA. The framework proposed by the panel includes three key domains where e-HPA differs qualitatively from earlier generations of models and algorithms (Data Barriers, Transparency, and ETHICS) and areas where current frameworks are insufficient to address the emerging opportunities and challenges of e-HPA (Regulation and Certification; and Education and Training). The following list of recommendations summarizes the key points of the framework: Data Barriers: Establish mechanisms within the scientific community to support data sharing for predictive model development and testing.Transparency: Set standards around e-HPA validation based on principles of scientific transparency and reproducibility. Develop both individual-centered and society-centered risk-benefit approaches to evaluate e-HPA.Regulation and Certification: Construct a

  15. Challenges for eco-design of emerging technologies: The case of electronic textiles

    International Nuclear Information System (INIS)

    Köhler, Andreas R.

    2013-01-01

    Highlights: • Recent innovations of electronic textiles and their end-of-life impacts are reviewed. • The properties of e-textiles are examined against Design for Recycling (DfR) principles. • Eco-design strategies for sustainable product development are discussed. • Compatibility standards for e-textiles are proposed as a waste prevention strategy. • Labelling of e-textiles is suggested as a measure to facilitate recycling. - Abstract: The combination of textile and electronic technologies results in new challenges for sustainable product design. Electronic textiles (e-textiles) feature a seamless integration of textiles with electronics and other high-tech materials. Such products may, if they become mass consumer applications, result in a new kind of waste that could be difficult to recycle. The ongoing innovation process of e-textiles holds opportunities to prevent future end-of-life impacts. Implementing eco-design in the technological development process can help to minimise future waste. However, the existing Design for Recycling (DfR) principles for textiles or electronics do not match with the properties of the combined products. This article examines possibilities to advance eco-design of a converging technology. DfR strategies for e-textiles are discussed from the background of contemporary innovation trends. Three waste preventative eco-design approaches for e-textiles are discussed: 1 harnessing the inherent advantages of smart materials for sustainable design; 2 establishing open compatibility standards; 3 labelling the e-textiles to facilitate their recycling. It is argued that life-cycle thinking needs to be implemented concurrent to the technological development process

  16. Electronic Cigarettes and Vaping: A New Challenge in Clinical Medicine and Public Health. A Literature Review

    Science.gov (United States)

    Palazzolo, Dominic L.

    2013-01-01

    Electronic cigarette (e-cigarette) use, or vaping, in the United States and worldwide is increasing. Their use is highly controversial from scientific, political, financial, psychological, and sociological ideologies. Given the controversial nature of e-cigarettes and vaping, how should medical care providers advise their patients? To effectively face this new challenge, health care professionals need to become more familiar with the existing literature concerning e-cigarettes and vaping, especially the scientific literature. Thus, the aim of this article is to present a review of the scientific evidence-based primary literature concerning electronic cigarettes and vaping. A search of the most current literature using the pubmed database dating back to 2008, and using electronic cigarette(s) or e-cigarette(s) as key words, yielded a total of 66 highly relevant articles. These articles primarily deal with (1) consumer-based surveys regarding personal views on vaping, (2) chemical analysis of e-cigarette cartridges, solutions, and mist, (3) nicotine content, delivery, and pharmacokinetics, and (4) clinical and physiological studies investigating the effects of acute vaping. When compared to the effects of smoking, the scant available literature suggests that vaping could be a “harm reduction” alternative to smoking and a possible means for smoking cessation, at least to the same degree as other Food and Drug Administration-approved nicotine replacement therapies. However, it is unclear if vaping e-cigarettes will reduce or increase nicotine addiction. It is obvious that more rigorous investigations of the acute and long-term health effects of vaping are required to establish the safety and efficacy of these devices; especially parallel experiments comparing the cardiopulmonary effects of vaping to smoking. Only then will the medical community be able to adequately meet the new challenge e-cigarettes and vaping present to clinical medicine and public health. PMID

  17. Electronic cigarettes and vaping: a new challenge in clinical medicine and public health. A literature review.

    Science.gov (United States)

    Palazzolo, Dominic L

    2013-11-18

    Electronic cigarette (e-cigarette) use, or vaping, in the United States and worldwide is increasing. Their use is highly controversial from scientific, political, financial, psychological, and sociological ideologies. Given the controversial nature of e-cigarettes and vaping, how should medical care providers advise their patients? To effectively face this new challenge, health care professionals need to become more familiar with the existing literature concerning e-cigarettes and vaping, especially the scientific literature. Thus, the aim of this article is to present a review of the scientific evidence-based primary literature concerning electronic cigarettes and vaping. A search of the most current literature using the pubmed database dating back to 2008, and using electronic cigarette(s) or e-cigarette(s) as key words, yielded a total of 66 highly relevant articles. These articles primarily deal with (1) consumer-based surveys regarding personal views on vaping, (2) chemical analysis of e-cigarette cartridges, solutions, and mist, (3) nicotine content, delivery, and pharmacokinetics, and (4) clinical and physiological studies investigating the effects of acute vaping. When compared to the effects of smoking, the scant available literature suggests that vaping could be a "harm reduction" alternative to smoking and a possible means for smoking cessation, at least to the same degree as other Food and Drug Administration-approved nicotine replacement therapies. However, it is unclear if vaping e-cigarettes will reduce or increase nicotine addiction. It is obvious that more rigorous investigations of the acute and long-term health effects of vaping are required to establish the safety and efficacy of these devices; especially parallel experiments comparing the cardiopulmonary effects of vaping to smoking. Only then will the medical community be able to adequately meet the new challenge e-cigarettes and vaping present to clinical medicine and public health.

  18. Evaluation and comparison of 3D intervertebral disc localization and segmentation methods for 3D T2 MR data: A grand challenge.

    Science.gov (United States)

    Zheng, Guoyan; Chu, Chengwen; Belavý, Daniel L; Ibragimov, Bulat; Korez, Robert; Vrtovec, Tomaž; Hutt, Hugo; Everson, Richard; Meakin, Judith; Andrade, Isabel Lŏpez; Glocker, Ben; Chen, Hao; Dou, Qi; Heng, Pheng-Ann; Wang, Chunliang; Forsberg, Daniel; Neubert, Aleš; Fripp, Jurgen; Urschler, Martin; Stern, Darko; Wimmer, Maria; Novikov, Alexey A; Cheng, Hui; Armbrecht, Gabriele; Felsenberg, Dieter; Li, Shuo

    2017-01-01

    The evaluation of changes in Intervertebral Discs (IVDs) with 3D Magnetic Resonance (MR) Imaging (MRI) can be of interest for many clinical applications. This paper presents the evaluation of both IVD localization and IVD segmentation methods submitted to the Automatic 3D MRI IVD Localization and Segmentation challenge, held at the 2015 International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI2015) with an on-site competition. With the construction of a manually annotated reference data set composed of 25 3D T2-weighted MR images acquired from two different studies and the establishment of a standard validation framework, quantitative evaluation was performed to compare the results of methods submitted to the challenge. Experimental results show that overall the best localization method achieves a mean localization distance of 0.8 mm and the best segmentation method achieves a mean Dice of 91.8%, a mean average absolute distance of 1.1 mm and a mean Hausdorff distance of 4.3 mm, respectively. The strengths and drawbacks of each method are discussed, which provides insights into the performance of different IVD localization and segmentation methods. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Metal-Halide Perovskite Transistors for Printed Electronics: Challenges and Opportunities

    KAUST Repository

    Lin, Yen-Hung

    2017-10-12

    Following the unprecedented rise in photovoltaic power conversion efficiencies during the past five years, metal-halide perovskites (MHPs) have emerged as a new and highly promising class of solar-energy materials. Their extraordinary electrical and optical properties combined with the abundance of the raw materials, the simplicity of synthetic routes, and processing versatility make MHPs ideal for cost-efficient, large-volume manufacturing of a plethora of optoelectronic devices that span far beyond photovoltaics. Herein looks beyond current applications in the field of energy, to the area of large-area electronics using MHPs as the semiconductor material. A comprehensive overview of the relevant fundamental material properties of MHPs, including crystal structure, electronic states, and charge transport, is provided first. Thereafter, recent demonstrations of MHP-based thin-film transistors and their application in logic circuits, as well as bi-functional devices such as light-sensing and light-emitting transistors, are discussed. Finally, the challenges and opportunities in the area of MHPs-based electronics, with particular emphasis on manufacturing, stability, and health and environmental concerns, are highlighted.

  20. Challenges of microtome‐based serial block‐face scanning electron microscopy in neuroscience

    Science.gov (United States)

    WANNER, A. A.; KIRSCHMANN, M. A.

    2015-01-01

    Summary Serial block‐face scanning electron microscopy (SBEM) is becoming increasingly popular for a wide range of applications in many disciplines from biology to material sciences. This review focuses on applications for circuit reconstruction in neuroscience, which is one of the major driving forces advancing SBEM. Neuronal circuit reconstruction poses exceptional challenges to volume EM in terms of resolution, field of view, acquisition time and sample preparation. Mapping the connections between neurons in the brain is crucial for understanding information flow and information processing in the brain. However, information on the connectivity between hundreds or even thousands of neurons densely packed in neuronal microcircuits is still largely missing. Volume EM techniques such as serial section TEM, automated tape‐collecting ultramicrotome, focused ion‐beam scanning electron microscopy and SBEM (microtome serial block‐face scanning electron microscopy) are the techniques that provide sufficient resolution to resolve ultrastructural details such as synapses and provides sufficient field of view for dense reconstruction of neuronal circuits. While volume EM techniques are advancing, they are generating large data sets on the terabyte scale that require new image processing workflows and analysis tools. In this review, we present the recent advances in SBEM for circuit reconstruction in neuroscience and an overview of existing image processing and analysis pipelines. PMID:25907464

  1. Metal-Halide Perovskite Transistors for Printed Electronics: Challenges and Opportunities.

    Science.gov (United States)

    Lin, Yen-Hung; Pattanasattayavong, Pichaya; Anthopoulos, Thomas D

    2017-12-01

    Following the unprecedented rise in photovoltaic power conversion efficiencies during the past five years, metal-halide perovskites (MHPs) have emerged as a new and highly promising class of solar-energy materials. Their extraordinary electrical and optical properties combined with the abundance of the raw materials, the simplicity of synthetic routes, and processing versatility make MHPs ideal for cost-efficient, large-volume manufacturing of a plethora of optoelectronic devices that span far beyond photovoltaics. Herein looks beyond current applications in the field of energy, to the area of large-area electronics using MHPs as the semiconductor material. A comprehensive overview of the relevant fundamental material properties of MHPs, including crystal structure, electronic states, and charge transport, is provided first. Thereafter, recent demonstrations of MHP-based thin-film transistors and their application in logic circuits, as well as bi-functional devices such as light-sensing and light-emitting transistors, are discussed. Finally, the challenges and opportunities in the area of MHPs-based electronics, with particular emphasis on manufacturing, stability, and health and environmental concerns, are highlighted. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Primary Care Practices’ Abilities And Challenges In Using Electronic Health Record Data For Quality Improvement

    Science.gov (United States)

    Cohen, Deborah J.; Dorr, David A.; Knierim, Kyle; DuBard, C. Annette; Hemler, Jennifer R.; Hall, Jennifer D.; Marino, Miguel; Solberg, Leif I.; McConnell, K. John; Nichols, Len M.; Nease, Donald E.; Edwards, Samuel T.; Wu, Winfred Y.; Pham-Singer, Hang; Kho, Abel N.; Phillips, Robert L.; Rasmussen, Luke V.; Duffy, F. Daniel; Balasubramanian, Bijal A.

    2018-01-01

    Federal value-based payment programs require primary care practices to conduct quality improvement activities, informed by the electronic reports on clinical quality measures that their electronic health records (EHRs) generate. To determine whether EHRs produce reports adequate to the task, we examined survey responses from 1,492 practices across twelve states, supplemented with qualitative data. Meaningful-use participation, which requires the use of a federally certified EHR, was associated with the ability to generate reports—but the reports did not necessarily support quality improvement initiatives. Practices reported numerous challenges in generating adequate reports, such as difficulty manipulating and aligning measurement time frames with quality improvement needs, lack of functionality for generating reports on electronic clinical quality measures at different levels, discordance between clinical guidelines and measures available in reports, questionable data quality, and vendors that were unreceptive to changing EHR configuration beyond federal requirements. The current state of EHR measurement functionality may be insufficient to support federal initiatives that tie payment to clinical quality measures. PMID:29608365

  3. Primary Care Practices' Abilities And Challenges In Using Electronic Health Record Data For Quality Improvement.

    Science.gov (United States)

    Cohen, Deborah J; Dorr, David A; Knierim, Kyle; DuBard, C Annette; Hemler, Jennifer R; Hall, Jennifer D; Marino, Miguel; Solberg, Leif I; McConnell, K John; Nichols, Len M; Nease, Donald E; Edwards, Samuel T; Wu, Winfred Y; Pham-Singer, Hang; Kho, Abel N; Phillips, Robert L; Rasmussen, Luke V; Duffy, F Daniel; Balasubramanian, Bijal A

    2018-04-01

    Federal value-based payment programs require primary care practices to conduct quality improvement activities, informed by the electronic reports on clinical quality measures that their electronic health records (EHRs) generate. To determine whether EHRs produce reports adequate to the task, we examined survey responses from 1,492 practices across twelve states, supplemented with qualitative data. Meaningful-use participation, which requires the use of a federally certified EHR, was associated with the ability to generate reports-but the reports did not necessarily support quality improvement initiatives. Practices reported numerous challenges in generating adequate reports, such as difficulty manipulating and aligning measurement time frames with quality improvement needs, lack of functionality for generating reports on electronic clinical quality measures at different levels, discordance between clinical guidelines and measures available in reports, questionable data quality, and vendors that were unreceptive to changing EHR configuration beyond federal requirements. The current state of EHR measurement functionality may be insufficient to support federal initiatives that tie payment to clinical quality measures.

  4. The formal electronic recycling industry: Challenges and opportunities in occupational and environmental health research.

    Science.gov (United States)

    Ceballos, Diana Maria; Dong, Zhao

    2016-10-01

    E-waste includes electrical and electronic equipment discarded as waste without intent of reuse. Informal e-waste recycling, typically done in smaller, unorganized businesses, can expose workers and communities to serious chemical health hazards. It is unclear if formalization into larger, better-controlled electronics recycling (e-recycling) facilities solves environmental and occupational health problems. To systematically review the literature on occupational and environmental health hazards of formal e-recycling facilities and discuss challenges and opportunities to strengthen research in this area. We identified 37 publications from 4 electronic databases (PubMed, Web of Science, Environmental Index, NIOSHTIC-2) specific to chemical exposures in formal e-recycling facilities. Environmental and occupational exposures depend on the degree of formalization of the facilities but further reduction is needed. Reported worker exposures to metals were often higher than recommended occupational guidelines. Levels of brominated flame-retardants in worker's inhaled air and biological samples were higher than those from reference groups. Air, dust, and soil concentrations of metals, brominated flame-retardants, dioxins, furans, polycyclic-aromatic hydrocarbons, or polychlorinated biphenyls found inside or near the facilities were generally higher than reference locations, suggesting transport into the environment. Children of a recycler had blood lead levels higher than public health recommended guidelines. With mounting e-waste, more workers, their family members, and communities could experience unhealthful exposures to metals and other chemicals. We identified research needs to further assess exposures, health, and improve controls. The long-term solution is manufacturing of electronics without harmful substances and easy-to-disassemble components. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  5. Scientific Grand Challenges: Discovery In Basic Energy Sciences: The Role of Computing at the Extreme Scale - August 13-15, 2009, Washington, D.C.

    Energy Technology Data Exchange (ETDEWEB)

    Galli, Giulia [Univ. of California, Davis, CA (United States). Workshop Chair; Dunning, Thom [Univ. of Illinois, Urbana, IL (United States). Workshop Chair

    2009-08-13

    The U.S. Department of Energy’s (DOE) Office of Basic Energy Sciences (BES) and Office of Advanced Scientific Computing Research (ASCR) workshop in August 2009 on extreme-scale computing provided a forum for more than 130 researchers to explore the needs and opportunities that will arise due to expected dramatic advances in computing power over the next decade. This scientific community firmly believes that the development of advanced theoretical tools within chemistry, physics, and materials science—combined with the development of efficient computational techniques and algorithms—has the potential to revolutionize the discovery process for materials and molecules with desirable properties. Doing so is necessary to meet the energy and environmental challenges of the 21st century as described in various DOE BES Basic Research Needs reports. Furthermore, computational modeling and simulation are a crucial complement to experimental studies, particularly when quantum mechanical processes controlling energy production, transformations, and storage are not directly observable and/or controllable. Many processes related to the Earth’s climate and subsurface need better modeling capabilities at the molecular level, which will be enabled by extreme-scale computing.

  6. Susceptibility and hardening of electronic systems to fast transient threats: new challenges ahead

    Directory of Open Access Journals (Sweden)

    F. Sabath

    2004-01-01

    Full Text Available The field of susceptibility and hardening of electronic systems to transient threats has experienced a significant growth during the past ten years. Driven by the development in the area of non-lethal electromagnetic weapons it has become necessary to extend the classical set of transient threats, consisting of LEMP, ESD and NEMP, by a fast transient threat with an extreme bandwidth. The investigation of the susceptibility to those UWB threats, characterized by a bandwidth of more than a quarter of the center frequency, rise times of less than 200 ps and pulse durations in the ns regime, is of special interest. This paper presents an overview of current challenges of the hardening against UWB threats. It discusses recent research trends in transient susceptibility measurements, protection concepts and methods of analysis.

  7. Electronics and triggering challenges for the CMS High Granularity Calorimeter for HL-LHC

    CERN Document Server

    Borg, Johan

    2017-01-01

    The High Granularity Calorimeter (HGCAL) is presently being designedto replace the CMS endcap calorimeters for the HighLuminosity phase at LHC. It will feature six million silicon sensor channelsand 52 longitudinal layers. The requirements for the frontendelectronics include a 0.3 fC-10 pC dynamic range, low noise (2000 e-) and low power consumption (10 mW /channel).In addition, the HGCAL will perform 50 ps resolution time of arrivalmeasurements to combat the effect of the large number of interactions taking placeat each bunch crossing, and will transmit both triggered readoutfrom on-detector buffer memory and reduced resolution real-time trigger data.We present the challenges related to the frontend electronics, data transmissionand off-detector trigger preprocessing that must be overcome, and the designconcepts currently being pursued.

  8. Approaches and challenges to optimising primary care teams’ electronic health record usage

    Directory of Open Access Journals (Sweden)

    Nancy Pandhi

    2014-07-01

    Full Text Available Background Although the presence of an electronic health record (EHR alone does not ensure high quality, efficient care, few studies have focused on the work of those charged with optimising use of existing EHR functionality.Objective To examine the approaches used and challenges perceived by analysts supporting the optimisation of primary care teams’ EHR use at a large U.S. academic health care system.Methods A qualitative study was conducted. Optimisation analysts and their supervisor were interviewed and data were analysed for themes.Results Analysts needed to reconcile the tension created by organisational mandates focused on the standardisation of EHR processes with the primary care teams’ demand for EHR customisation. They gained an understanding of health information technology (HIT leadership’s and primary care team’s goals through attending meetings, reading meeting minutes and visiting with clinical teams. Within what was organisationally possible, EHR education could then be tailored to fit team needs. Major challenges were related to organisational attempts to standardise EHR use despite varied clinic contexts, personnel readiness and technical issues with the EHR platform. Forcing standardisation upon clinical needs that current EHR functionality could not satisfy was difficult.Conclusions Dedicated optimisation analysts can add value to health systems through playing a mediating role between HIT leadership and care teams. Our findings imply that EHR optimisation should be performed with an in-depth understanding of the workflow, cognitive and interactional activities in primary care.

  9. Measurement and Instrumentation Challenges at X-ray Free Electron Lasers

    Science.gov (United States)

    Feng, Yiping

    2015-03-01

    X-ray Free Electron Laser sources based on the Self Amplified Spontaneous Emission process are intrinsically chaotic, giving rise to pulse-to-pulse fluctuations in all physical properties, including intensity, position and pointing, spatial and temporal profiles, spectral content, timing, and coherence. These fluctuations represents special challenges to users whose experiments are designed to reveal small changes in the underlying physical quantities, which would otherwise be completely washed out without using the proper diagnostics tools. Due to the X-ray FEL's unique characteristics such as the unprecedented peak power and nearly full spatial coherence, there are many technical challenges in conceiving and implementing these devices that are highly transmissive, provide sufficient signal-to-noise ratio, and most importantly work in the single-shot mode. Portions of this research were carried out at the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory. LCLS is an Office of Science User Facility operated for the U.S. Department of Energy Office of Science by Stanford Univ.

  10. Identification of Chinese Herbal Medicines with Electronic Nose Technology: Applications and Challenges

    Directory of Open Access Journals (Sweden)

    Huaying Zhou

    2017-05-01

    Full Text Available This paper provides a review of the most recent works in machine olfaction as applied to the identification of Chinese Herbal Medicines (CHMs. Due to the wide variety of CHMs, the complexity of growing sources and the diverse specifications of herb components, the quality control of CHMs is a challenging issue. Much research has demonstrated that an electronic nose (E-nose as an advanced machine olfaction system, can overcome this challenge through identification of the complex odors of CHMs. E-nose technology, with better usability, high sensitivity, real-time detection and non-destructive features has shown better performance in comparison with other analytical techniques such as gas chromatography-mass spectrometry (GC-MS. Although there has been immense development of E-nose techniques in other applications, there are limited reports on the application of E-noses for the quality control of CHMs. The aim of current study is to review practical implementation and advantages of E-noses for robust and effective odor identification of CHMs. It covers the use of E-nose technology to study the effects of growing regions, identification methods, production procedures and storage time on CHMs. Moreover, the challenges and applications of E-nose for CHM identification are investigated. Based on the advancement in E-nose technology, odor may become a new quantitative index for quality control of CHMs and drug discovery. It was also found that more research could be done in the area of odor standardization and odor reproduction for remote sensing.

  11. Identification of Chinese Herbal Medicines with Electronic Nose Technology: Applications and Challenges.

    Science.gov (United States)

    Zhou, Huaying; Luo, Dehan; GholamHosseini, Hamid; Li, Zhong; He, Jiafeng

    2017-05-09

    This paper provides a review of the most recent works in machine olfaction as applied to the identification of Chinese Herbal Medicines (CHMs). Due to the wide variety of CHMs, the complexity of growing sources and the diverse specifications of herb components, the quality control of CHMs is a challenging issue. Much research has demonstrated that an electronic nose (E-nose) as an advanced machine olfaction system, can overcome this challenge through identification of the complex odors of CHMs. E-nose technology, with better usability, high sensitivity, real-time detection and non-destructive features has shown better performance in comparison with other analytical techniques such as gas chromatography-mass spectrometry (GC-MS). Although there has been immense development of E-nose techniques in other applications, there are limited reports on the application of E-noses for the quality control of CHMs. The aim of current study is to review practical implementation and advantages of E-noses for robust and effective odor identification of CHMs. It covers the use of E-nose technology to study the effects of growing regions, identification methods, production procedures and storage time on CHMs. Moreover, the challenges and applications of E-nose for CHM identification are investigated. Based on the advancement in E-nose technology, odor may become a new quantitative index for quality control of CHMs and drug discovery. It was also found that more research could be done in the area of odor standardization and odor reproduction for remote sensing.

  12. Front-end electronics and trigger systems-Status and challenges

    International Nuclear Information System (INIS)

    Spieler, Helmuth

    2007-01-01

    The past quarter century has brought about a revolution in front-end electronics for large-scale detector systems. Custom integrated circuits specifically tailored to the requirements of large detector systems have provided unprecedented performance and enabled systems that once were deemed impossible. The evolution of integrated circuit readouts in strip detectors is summarized, the present status described, and challenges posed by the sLHC and ILC are discussed. Performance requirements increase, but key considerations remain as in the past: power dissipation, material, and services. Smaller CMOS feature sizes will not reduce the power required for the desired noise levels, but will improve digital power efficiency. Significant improvements appear to be practical in more efficient power distribution. Enhanced digital electronics have provided powerful trigger processors that greatly improve the trigger efficiency. In data readout systems, they also improve data throughput, while reducing power requirements. Concurrently with new developments in high energy physics, detector systems for cosmology and astrophysics have made great strides. As an example, a large-scale readout for superconducting bolometer arrays is described

  13. What if Things Get Worse? Really Grand Challenges for Modeling and Simulation in a Risky and Complex World or Modeling and Simulation for the "Greater Good"?

    Science.gov (United States)

    Fifrey, Priscilla

    2010-01-01

    electronics and hydraulics, these are effectively the brains of the blowout preventer. No one fixed it, he alleges, they just shut it down and relied on the other control pod -an act deemed unacceptable by petroleum expert, Tad Patzek, at the University of Texas. The US Congress has identified numerous other problems with the blowout preventer, including design problems and unexpected modifications.

  14. Grand Hotel prijutil hudozhnikov

    Index Scriptorium Estoniae

    2004-01-01

    Raadioajakirjanik Lea Veelmaa lindistas "Kunstikanali" 2004. a. esimese saate Grand Hotel Viljandis. Saatekülaliseks oli maalikunstnik Andres Tolts. Toltsi kaheksa akrüülmaali on eksponeeritud hotelli fuajees ja restoranis

  15. Grand Mal Seizure

    Science.gov (United States)

    ... grand mal seizures include: A family history of seizure disorders Any injury to the brain from trauma, a ... the risk of birth defects. If you have epilepsy and plan to become pregnant, work with your ...

  16. Challenges for single molecule electronic devices with nanographene and organic molecules. Do single molecules offer potential as elements of electronic devices in the next generation?

    Science.gov (United States)

    Enoki, Toshiaki; Kiguchi, Manabu

    2018-03-01

    Interest in utilizing organic molecules to fabricate electronic materials has existed ever since organic (molecular) semiconductors were first discovered in the 1950s. Since then, scientists have devoted serious effort to the creation of various molecule-based electronic systems, such as molecular metals and molecular superconductors. Single-molecule electronics and the associated basic science have emerged over the past two decades and provided hope for the development of highly integrated molecule-based electronic devices in the future (after the Si-based technology era has ended). Here, nanographenes (nano-sized graphene) with atomically precise structures are among the most promising molecules that can be utilized for electronic/spintronic devices. To manipulate single small molecules for an electronic device, a single molecular junction has been developed. It is a powerful tool that allows even small molecules to be utilized. External electric, magnetic, chemical, and mechanical perturbations can change the physical and chemical properties of molecules in a way that is different from bulk materials. Therefore, the various functionalities of molecules, along with changes induced by external perturbations, allows us to create electronic devices that we cannot create using current top-down Si-based technology. Future challenges that involve the incorporation of condensed matter physics, quantum chemistry calculations, organic synthetic chemistry, and electronic device engineering are expected to open a new era in single-molecule device electronic technology.

  17. Design challenges for electronic medication administration record systems in residential aged care facilities: a formative evaluation.

    Science.gov (United States)

    Tariq, A; Lehnbom, E; Oliver, K; Georgiou, A; Rowe, C; Osmond, T; Westbrook, J

    2014-01-01

    Electronic medication administration record (eMAR) systems are promoted as a potential intervention to enhance medication safety in residential aged care facilities (RACFs). The purpose of this study was to conduct an in-practice evaluation of an eMAR being piloted in one Australian RACF before its roll out, and to provide recommendations for system improvements. A multidisciplinary team conducted direct observations of workflow (n=34 hours) in the RACF site and the community pharmacy. Semi-structured interviews (n=5) with RACF staff and the community pharmacist were conducted to investigate their views of the eMAR system. Data were analysed using a grounded theory approach to identify challenges associated with the design of the eMAR system. The current eMAR system does not offer an end-to-end solution for medication management. Many steps, including prescribing by doctors and communication with the community pharmacist, are still performed manually using paper charts and fax machines. Five major challenges associated with the design of eMAR system were identified: limited interactivity; inadequate flexibility; problems related to information layout and semantics; the lack of relevant decision support; and system maintenance issues. We suggest recommendations to improve the design of the eMAR system and to optimize existing workflows. Immediate value can be achieved by improving the system interactivity, reducing inconsistencies in data entry design and offering dedicated organisational support to minimise connectivity issues. Longer-term benefits can be achieved by adding decision support features and establishing system interoperability requirements with stakeholder groups (e.g. community pharmacies) prior to system roll out. In-practice evaluations of technologies like eMAR system have great value in identifying design weaknesses which inhibit optimal system use.

  18. The challenge of electronic waste (e-waste) management in developing countries.

    Science.gov (United States)

    Osibanjo, O; Nnorom, I C

    2007-12-01

    Information and telecommunications technology (ICT) and computer Internet networking has penetrated nearly every aspect of modern life, and is positively affecting human life even in the most remote areas of the developing countries. The rapid growth in ICT has led to an improvement in the capacity of computers but simultaneously to a decrease in the products lifetime as a result of which increasingly large quantities of waste electrical and electronic equipment (e-waste) are generated annually. ICT development in most developing countries, particularly in Africa, depends more on secondhand or refurbished EEEs most of which are imported without confirmatory testing for functionality. As a result large quantities of e-waste are presently being managed in these countries. The challenges facing the developing countries in e-waste management include: an absence of infrastructure for appropriate waste management, an absence of legislation dealing specifically with e-waste, an absence of any framework for end-of-life (EoL) product take-back or implementation of extended producer responsibility (EPR). This study examines these issues as they relate to practices in developing countries with emphasis on the prevailing situation in Nigeria. Effective management of e-waste in the developing countries demands the implementation of EPR, the establishment of product reuse through remanufacturing and the introduction of efficient recycling facilities. The implementation of a global system for the standardization and certification/labelling of secondhand appliances intended for export to developing countries will be required to control the export of electronic recyclables (e-scarp) in the name of secondhand appliances.

  19. Electronic Health Records Data and Metadata: Challenges for Big Data in the United States.

    Science.gov (United States)

    Sweet, Lauren E; Moulaison, Heather Lea

    2013-12-01

    This article, written by researchers studying metadata and standards, represents a fresh perspective on the challenges of electronic health records (EHRs) and serves as a primer for big data researchers new to health-related issues. Primarily, we argue for the importance of the systematic adoption of standards in EHR data and metadata as a way of promoting big data research and benefiting patients. EHRs have the potential to include a vast amount of longitudinal health data, and metadata provides the formal structures to govern that data. In the United States, electronic medical records (EMRs) are part of the larger EHR. EHR data is submitted by a variety of clinical data providers and potentially by the patients themselves. Because data input practices are not necessarily standardized, and because of the multiplicity of current standards, basic interoperability in EHRs is hindered. Some of the issues with EHR interoperability stem from the complexities of the data they include, which can be both structured and unstructured. A number of controlled vocabularies are available to data providers. The continuity of care document standard will provide interoperability in the United States between the EMR and the larger EHR, potentially making data input by providers directly available to other providers. The data involved is nonetheless messy. In particular, the use of competing vocabularies such as the Systematized Nomenclature of Medicine-Clinical Terms, MEDCIN, and locally created vocabularies inhibits large-scale interoperability for structured portions of the records, and unstructured portions, although potentially not machine readable, remain essential. Once EMRs for patients are brought together as EHRs, the EHRs must be managed and stored. Adequate documentation should be created and maintained to assure the secure and accurate use of EHR data. There are currently a few notable international standards initiatives for EHRs. Organizations such as Health Level Seven

  20. Aligning innovation with grand societal challenges

    DEFF Research Database (Denmark)

    Ricard, Lykke Margot

    2016-01-01

    This paper investigates the European Technology Platforms (ETPs) in wind power and in CO2 capture and storage supported by the European Commission (EC). It examines the role of these Platforms in shaping the trajectory of European energy technology policy, and shows that the EC’s support for the ......This paper investigates the European Technology Platforms (ETPs) in wind power and in CO2 capture and storage supported by the European Commission (EC). It examines the role of these Platforms in shaping the trajectory of European energy technology policy, and shows that the EC’s support...... for the ETPs marks a change from a solely evidence-based policy approach to the use of bottom-up policies designed to mobilize human capital based on social actors’ expectations, uncertainties and visions. These two ETPs include hitherto missing ‘key players’ who can enhance commercial legitimacy on both...... a valuable first qualitative analysis of this phenomenon which is emerging as a new policy instrument....

  1. Grand Challenges: Nanotechnology and the Social Studies

    Science.gov (United States)

    Manfra, Meghan McGlinn

    2013-01-01

    This article explores a multidisciplinary lesson on nanotechnology that can provide an effective means for teaching about both STEM and social studies topics. This approach encourages students to consider the "role that science and technology play in our lives and in our cultures." The extraordinary promise of nanotechnology, however, is…

  2. Density-functional expansion methods: Grand challenges.

    Science.gov (United States)

    Giese, Timothy J; York, Darrin M

    2012-03-01

    We discuss the source of errors in semiempirical density functional expansion (VE) methods. In particular, we show that VE methods are capable of well-reproducing their standard Kohn-Sham density functional method counterparts, but suffer from large errors upon using one or more of these approximations: the limited size of the atomic orbital basis, the Slater monopole auxiliary basis description of the response density, and the one- and two-body treatment of the core-Hamiltonian matrix elements. In the process of discussing these approximations and highlighting their symptoms, we introduce a new model that supplements the second-order density-functional tight-binding model with a self-consistent charge-dependent chemical potential equalization correction; we review our recently reported method for generalizing the auxiliary basis description of the atomic orbital response density; and we decompose the first-order potential into a summation of additive atomic components and many-body corrections, and from this examination, we provide new insights and preliminary results that motivate and inspire new approximate treatments of the core-Hamiltonian.

  3. The 'Grand Paris' project: Tools and challenges

    OpenAIRE

    De Palma, André

    2011-01-01

    The purpose of this Round Table is to assess the economic effects of major transport infrastructure projects. The term major projects is used to designate qualitative leaps, be it the mapping out of new road or rail rings to link disparate radial penetration routes or the introduction of more-targeted innovations tackling frequency, speed or automation. (...)

  4. The potentials and challenges of electron microscopy in the study of atomic chains

    Science.gov (United States)

    Banhart, Florian; Torre, Alessandro La; Romdhane, Ferdaous Ben; Cretu, Ovidiu

    2017-04-01

    The article is a brief review on the potential of transmission electron microscopy (TEM) in the investigation of atom chains which are the paradigm of a strictly one-dimensional material. After the progress of TEM in the study of new two-dimensional materials, microscopy of free-standing one-dimensional structures is a new challenge with its inherent potentials and difficulties. In-situ experiments in the TEM allowed, for the first time, to generate isolated atomic chains consisting of metals, carbon or boron nitride. Besides having delivered a solid proof for the existence of atomic chains, in-situ TEM studies also enabled us to measure the electrical properties of these fundamental linear structures. While ballistic quantum conductivity is observed in chains of metal atoms, electrical transport in chains of sp1-hybridized carbon is limited by resonant states and reflections at the contacts. Although substantial progress has been made in recent TEM studies of atom chains, fundamental questions have to be answered, concerning the structural stability of the chains, bonding states at the contacts, and the suitability for applications in nanotechnology. Contribution to the topical issue "The 16th European Microscopy Congress (EMC 2016)", edited by Richard Brydson and Pascale Bayle-Guillemaud

  5. Google Earth Grand Tour Themes

    Science.gov (United States)

    De Paor, D. G.; Whitmeyer, S. J.; Bentley, C.; Dordevic, M. M.

    2014-12-01

    As part of an NSF TUES Type 3 project entitled "Google Earth for Onsite and Distance Education (GEODE)," we are assembling a "Grand Tour" of locations on Earth and other terrestrial bodies that every geoscience student should know about and visit at least in virtual reality. Based on feedback from colleagues at previous meetings, we have identified nine Grand Tour themes: "Plates and Plumes," "Rocks and Regions," "Geology Through Time," "The Mapping Challenge*," "U.S. National Parks*," "The Magical Mystery Tour*," "Resources and Hazards," "Planets and Moons," and "Top of the Pops." Themes marked with an asterisk are most developed at this stage and will be demonstrated in real time. The Mapping Challenge invites students to trace geological contacts, measure bedding strike and dip and the plunge, trend, and facing of a fold. There is an advanced tool for modeling periclinal folds. The challenge is presented in a game-like format with an emphasis on puzzle-solving that will appeal to students regardless of gender. For the tour of U.S. national parks, we divided the most geologically important parks into four groups—Western Pacific, West Coast, Rockies, and East Coast. We are combining our own team's GigaPan imagery with imagery already available on the Internet. There is a great deal of imagery just waiting to be annotated for geological education purposes. The Magical Mystery Tour takes students to Google Streetview locations selected by instructors. Students are presented with questions or tasks and are given automatic feedback. Other themes are under development. Within each theme, we are crowd-sourcing contributions from colleagues and inviting colleagues to vote for or against proposed locations and student interactions. The GEODE team includes the authors and: Heather Almquist, Stephen Burgin, Cinzia Cervato, Gene Cooper, Paul Karabinos, Terry Pavlis, Jen Piatek, Bill Richards, Jeff Ryan, Ron Schott, Kristen St. John, and Barb Tewksbury.

  6. Adaptation to the electronics of fast and highly efficient fission chambers; Adaptation a l'electronique de chambres a fission rapides et de grande efficacite

    Energy Technology Data Exchange (ETDEWEB)

    Buisson, Jacques

    1968-09-04

    When designing a fast and highly efficient sensor, not only optimal values of the sensor per se (nature of the filling gas, pressure, electric field, etc.), but also its adaptation to the cable of connection to the electronics must be taken into account. The author reports the development of the expression of the characteristic impedance of fission chambers and the determination of elementary tubes. He reports the theoretical study of the amplitude of pulses produced by a sensor in the case of a non-adapted sensor and in the case of an adapted sensor. It appears that an adapted chamber does not possess only benefits, but is an interesting solution only when the sensor collection time is very short and when the compliance with its speed is the essential objective. Some recommendations are made for the electronics characteristics, and for the connection cable (very low losses, which means a greater diameter than the current one)

  7. Big data from electronic health records for early and late translational cardiovascular research: challenges and potential.

    Science.gov (United States)

    Hemingway, Harry; Asselbergs, Folkert W; Danesh, John; Dobson, Richard; Maniadakis, Nikolaos; Maggioni, Aldo; van Thiel, Ghislaine J M; Cronin, Maureen; Brobert, Gunnar; Vardas, Panos; Anker, Stefan D; Grobbee, Diederick E; Denaxas, Spiros

    2018-04-21

    Cohorts of millions of people's health records, whole genome sequencing, imaging, sensor, societal and publicly available data present a rapidly expanding digital trace of health. We aimed to critically review, for the first time, the challenges and potential of big data across early and late stages of translational cardiovascular disease research. We sought exemplars based on literature reviews and expertise across the BigData@Heart Consortium. We identified formidable challenges including: data quality, knowing what data exist, the legal and ethical framework for their use, data sharing, building and maintaining public trust, developing standards for defining disease, developing tools for scalable, replicable science and equipping the clinical and scientific work force with new inter-disciplinary skills. Opportunities claimed for big health record data include: richer profiles of health and disease from birth to death and from the molecular to the societal scale; accelerated understanding of disease causation and progression, discovery of new mechanisms and treatment-relevant disease sub-phenotypes, understanding health and diseases in whole populations and whole health systems and returning actionable feedback loops to improve (and potentially disrupt) existing models of research and care, with greater efficiency. In early translational research we identified exemplars including: discovery of fundamental biological processes e.g. linking exome sequences to lifelong electronic health records (EHR) (e.g. human knockout experiments); drug development: genomic approaches to drug target validation; precision medicine: e.g. DNA integrated into hospital EHR for pre-emptive pharmacogenomics. In late translational research we identified exemplars including: learning health systems with outcome trials integrated into clinical care; citizen driven health with 24/7 multi-parameter patient monitoring to improve outcomes and population-based linkages of multiple EHR sources

  8. Challenges in the implementation of an electronic surveillance system in a resource-limited setting: Alerta, in Peru

    Directory of Open Access Journals (Sweden)

    Soto Giselle

    2008-11-01

    Full Text Available Abstract Background Infectious disease surveillance is a primary public health function in resource-limited settings. In 2003, an electronic disease surveillance system (Alerta was established in the Peruvian Navy with support from the U.S. Naval Medical Research Center Detachment (NMRCD. Many challenges arose during the implementation process, and a variety of solutions were applied. The purpose of this paper is to identify and discuss these issues. Methods This is a retrospective description of the Alerta implementation. After a thoughtful evaluation according to the Centers for Disease Control and Prevention (CDC guidelines, the main challenges to implementation were identified and solutions were devised in the context of a resource-limited setting, Peru. Results After four years of operation, we have identified a number of challenges in implementing and operating this electronic disease surveillance system. These can be divided into the following categories: (1 issues with personnel and stakeholders; (2 issues with resources in a developing setting; (3 issues with processes involved in the collection of data and operation of the system; and (4 issues with organization at the central hub. Some of the challenges are unique to resource-limited settings, but many are applicable for any surveillance system. For each of these challenges, we developed feasible solutions that are discussed. Conclusion There are many challenges to overcome when implementing an electronic disease surveillance system, not only related to technology issues. A comprehensive approach is required for success, including: technical support, personnel management, effective training, and cultural sensitivity in order to assure the effective deployment of an electronic disease surveillance system.

  9. THE JEOPARDIZED SITUATION OF ELECTRONIC WASTE IN BANGLADESH: CAN CUSTOMIZED POLICY APPROACH SOLVE THE CHALLENGE?

    Directory of Open Access Journals (Sweden)

    Khalid Md. Bahauddin

    2016-01-01

    Full Text Available Electronic waste (e-waste is one of the fastest-growing pollution problems worldwide given the presence if a variety of toxic substances which can contaminate the environment and threaten human health, if disposal protocols are not meticulously managed. In Bangladesh almost 2.7 million metric tons of e-waste generated per year. Of this amountonly 20 to 30 percent is recycled and the rest of the waste is released in to landfills,  rivers, drains lakes, canals, open spaces which are very hazardous for the health and environment. Since Bangladesh is in the stream of rapid technological advancement, it is seldom to take necessary steps to avoid the future jeopardized situation because of e-waste. The current practices of e-waste management in Bangladesh suffer from a number of drawbacks like the difficulty in inventorisation, unhealthy conditions of informal recycling, inadequate legislation and policy, poor awareness and reluctance on part of the corporate to address the critical issues. The paper highlights the associated issues and strategies to address this emerging problem, analyses the policy and its gaps. Therefore, this paper also suggest that e-waste policy development may require a more customized approach where, instead of addressing e-waste in isolation, it should be addressed as part of the national development agenda that integrates green economy assessment and strategic environmental assessment as part of national policy planning. Finally this work also suggests some alternative strategies and approaches to overcome the challenges of e-waste.

  10. Democracy and "Grand" Corruption.

    Science.gov (United States)

    Rose-Ackerman, Susan

    1996-01-01

    Defines "grand" corruption as that occurring at the higher levels of a political system and involving large sums of money. Discusses the impact and incentives for this level of corruption as well as various government responses. Identifies multinational corporations as the major malefactors. (MJP)

  11. The GRANDE detector

    International Nuclear Information System (INIS)

    Adams, A.; Bond, R.; Coleman, L.; Rollefson, A.; Wold, D.; Bratton, C.B.; Gurr, H.; Kropp, W.; Nelson, M.; Price, L.R.; Reines, F.; Schultz, J.; Sobel, H.; Svoboda, R.; Yodh, G.; Burnett, T.; Chaloupka, V.; Wilkes, R.J.; Cherry, M.; Ellison, S.B.; Guzik, T.G.; Wefel, J.; Gaidos, J.; Loeffler, F.; Sembroski, G.; Wilson, C.; Goodman, J.; Haines, T.J.; Kielczewska, D.; Lane, C.; Steinberg, R.; Lieber, M.; Nagle, D.; Potter, M.; Tripp, R.

    1990-01-01

    In this paper we present a detector facility which meets the requirements outlined above for a next-generation instrument. GRANDE (Gamma Ray and Neutrino DEtector) is an imaging, water Cerenkov detector, which combines in one facility an extensive air shower array and a high-energy neutrino detector. (orig.)

  12. Grand-Bassam

    African Journals Online (AJOL)

    Geo

    l'estuaire du fleuve Comoé (Grand-Bassam, Côte d'Ivoire). Kouassi Laurent ADOPO1*, Apie Colette AKOBE1, Etche Mireille AMANI2,. Sylvain MONDE3 et Kouamé AKA3. (1)Laboratoire de Géologie Marine, Sédimentologie et Environnement, Centre de Recherche en Ecologie,. Université Felix Houphouet Boigny Abidjan, ...

  13. Overview on thermal and mechanical challenges of high power RF electronic packaging

    NARCIS (Netherlands)

    Yuan, C.A.; Kregting, R.; Driel, W. van; Gielen, A.W.J.; Xiao, A.; Zhang, G.Q.

    2011-01-01

    High Power RF electronics is one of the essential parts for wireless communication, including the personal communication, broadcasting, microwave radar, etc. Moreover, high efficient high power electronics has entered the ISM market, such as the power generator of microwave oven. Power electronics

  14. Modeling of electron-specimen interaction in scanning electron microscope for e-beam metrology and inspection: challenges and perspectives

    Science.gov (United States)

    Suzuki, Makoto; Kameda, Toshimasa; Doi, Ayumi; Borisov, Sergey; Babin, Sergey

    2018-03-01

    The interpretation of scanning electron microscopy (SEM) images of the latest semiconductor devices is not intuitive and requires comparison with computed images based on theoretical modeling and simulations. For quantitative image prediction and geometrical reconstruction of the specimen structure, the accuracy of the physical model is essential. In this paper, we review the current models of electron-solid interaction and discuss their accuracy. We perform the comparison of the simulated results with our experiments of SEM overlay of under-layer, grain imaging of copper interconnect, and hole bottom visualization by angular selective detectors, and show that our model well reproduces the experimental results. Remaining issues for quantitative simulation are also discussed, including the accuracy of the charge dynamics, treatment of beam skirt, and explosive increase in computing time.

  15. Grand unified theories

    International Nuclear Information System (INIS)

    Langacker, P.

    1981-01-01

    In this talk I discuss the present status of these theories and of their observational and experimental implications. In section II, I briefly review the standard SU 3 sup(c) x SU 2 x U 1 model of the strong and electroweak interactions. Although phenomenologically successful, the standard model leaves many questions unanswered. Some of these questions are addressed by grand unified theories, which are defined and discussed in Section III. The Georgi-Glashow SU 5 model is described, as are theories based on larger groups such as SO 10 , E 6 , or SO 16 . It is emphasized that there are many possible grand unified theories and that it is an experimental problem not only to test the basic ideas but to discriminate between models. (orig./HSI)

  16. Asymptotically safe grand unification

    Energy Technology Data Exchange (ETDEWEB)

    Bajc, Borut [J. Stefan Institute,1000 Ljubljana (Slovenia); Sannino, Francesco [CP-Origins & the Danish IAS, University of Southern Denmark,Campusvej 55, DK-5230 Odense M (Denmark); Université de Lyon, France, Université Lyon 1, CNRS/IN2P3, UMR5822 IPNL,F-69622 Villeurbanne Cedex (France)

    2016-12-28

    Phenomenologically appealing supersymmetric grand unified theories have large gauge representations and thus are not asymptotically free. Their ultraviolet validity is limited by the appearance of a Landau pole well before the Planck scale. One could hope that these theories save themselves, before the inclusion of gravity, by generating an interacting ultraviolet fixed point, similar to the one recently discovered in non-supersymmetric gauge-Yukawa theories. Employing a-maximization, a-theorem, unitarity bounds, as well as positivity of other central charges we nonperturbatively rule out this possibility for a broad class of prime candidates of phenomenologically relevant supersymmetric grand unified theories. We also uncover candidates passing these tests, which have either exotic matter or contain one field decoupled from the superpotential. The latter class of theories contains a model with the minimal matter content required by phenomenology.

  17. LA GRANDE DESCENTE

    CERN Multimedia

    The first endcap disc of CMS being lowered slowly and carefully 100 m underground into the experimental cavern. The disc is one of 15 large pieces to make the grand descent.  The uniquely shaped slice, 16 m high, about 50 cm thick weighs 400 tonnes. The two HF that were lowered earlier in November can also be seen in the foreground and background.  

  18. Thermo-mechanical challenges in the longevity of micro-electronics

    NARCIS (Netherlands)

    Gielen, A.W.J.

    2010-01-01

    Automotive electronics, solid-state-lighting, and solar cells need have to operate under harsh circumstances, either by the kind of environment they operate in, such as automotive electronics under the hood, or by the long durations of exposure. In both cases traditional lifetime assessment methods

  19. Challenge of Engaging All Students via Self-Paced Interactive Electronic Learning Tutorials for Introductory Physics

    Science.gov (United States)

    DeVore, Seth; Marshman, Emily; Singh, Chandralekha

    2017-01-01

    As research-based, self-paced electronic learning tools become increasingly available, a critical issue educators encounter is implementing strategies to ensure that all students engage with them as intended. Here, we first discuss the effectiveness of electronic learning tutorials as self-paced learning tools in large enrollment brick and mortar…

  20. Electronic Government: Challenges to Effective Adoption of the Extensible Markup Language

    National Research Council Canada - National Science Library

    2002-01-01

    ...) technology and the challenges the federal government faces in implementing it. XML is a flexible, nonproprietary set of standards designed to facilitate the exchange of information among disparate computer systems, using the Internet's protocols...

  1. Challenges in legislation, recycling system and technical system of waste electrical and electronic equipment in China.

    Science.gov (United States)

    Zhang, Shengen; Ding, Yunji; Liu, Bo; Pan, De'an; Chang, Chein-chi; Volinsky, Alex A

    2015-11-01

    Waste electrical and electronic equipment (WEEE) has been one of the fastest growing waste streams worldwide. Effective and efficient management and treatment of WEEE has become a global problem. As one of the world's largest electronic products manufacturing and consumption countries, China plays a key role in the material life cycle of electrical and electronic equipment. Over the past 20 years, China has made a great effort to improve WEEE recycling. Centered on the legal, recycling and technical systems, this paper reviews the progresses of WEEE recycling in China. An integrated recycling system is proposed to realize WEEE high recycling rate for future WEEE recycling. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Aberration corrected and monochromated environmental transmission electron microscopy: challenges and prospects for materials science

    DEFF Research Database (Denmark)

    Hansen, Thomas Willum; Wagner, Jakob Birkedal; Dunin-Borkowski, Rafal E.

    2010-01-01

    The latest generation of environmental transmission electron microscopes incorporates aberration correctors and monochromators, allowing studies of chemical reactions and growth processes with improved spatial resolution and spectral sensitivity. Here, we describe the performance of such an instr...

  3. Free from the Constraints of Space and Time: Considering the Opportunities and Challenges for Electronic Publishing.

    Science.gov (United States)

    Eisenberg, Michael B.

    1994-01-01

    Provides a summary of the papers in this issue that deal with electronic publishing. Highlights include the impact on publishers, authors, users, and librarians and information technologists; theoretical frameworks; practical applications and implications; and future possibilities. (Contains 15 references.) (LRW)

  4. The quality of information in electronic scientific publications on the Internet: challenges and proposals

    Directory of Open Access Journals (Sweden)

    Marcelo SABBATINI

    2016-03-01

    Full Text Available The present work analises the main questions and hurdles involved in the adoption of a electronic scientific publication system, those related to the scientific community practices and rules of conduct. We emphasize the quality certification through peer review, interity and legitimiy maintenance and privacity preservation in the digital environment. Furthermore, we analise the academic community own perception of electronic journals available in Internet and its impacts in tenure and prommotion processes.

  5. Transformation of chinese retail industry: how to meet the new challenges by electronic business?

    OpenAIRE

    Liu, Xinyang; Li, Kai

    2015-01-01

    The past few decades witnessed the rise and expansion of electronic business (EB). An increasing number of companies are dealing with electronic commerce many of whom are well-known nationwide or worldwide leaders such as the Alibaba Group or JD.COM. On one day, 11th of November of 2014, the trading volume of Taobao reached 6 million RMB. The unprecedented development of EB has threatened traditional retail firms. Manufacturers as well as retailers need to reconsider their methods and make...

  6. The Philippines in the Electronics Global Value Chain: Upgrading Opportunities and Challenges

    OpenAIRE

    Rafaelita M. ALDABA

    2015-01-01

    This paper examines the extent and depth of participation of the Philippines in the electronics global value chains (GVC) using Trade in Value Added (TiVA) and extensive margin indicators. While the Philippines remains strong in semiconductors, it is lagging behind other ASEAN countries. According to the TiVA database, the level of participation of the Philippines in the electronics GVC increased substantially between 1995 and 2009. The extensive margins show that the Philippines has been reg...

  7. Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Denis Alcides-Rezende

    2008-01-01

    Full Text Available The objective of this work is to analyse the integration of information systems and information technology resources in the municipal planning of 14 small cities of Rio Grande do Sul (Brazil. The research methodology consisted of a multiple case study together with a convenient non-probabilistic sample chosen through a research protocol. The results demonstrate the difficulties of these cities to organise the municipal data as well as their struggle for accessibility of information and planning for management and control.

  8. Opportunities and challenges for comparative effectiveness research (CER) with Electronic Clinical Data: a perspective from the EDM forum.

    Science.gov (United States)

    Holve, Erin; Segal, Courtney; Hamilton Lopez, Marianne

    2012-07-01

    The Electronic Data Methods (EDM) Forum brings together perspectives from the Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies (PROSPECT) studies, the Scalable Distributed Research Networks, and the Enhanced Registries projects. This paper discusses challenges faced by the research teams as part of their efforts to develop electronic clinical data (ECD) infrastructure to support comparative effectiveness research (CER). The findings reflect a set of opportunities for transdisciplinary learning, and will ideally enhance the transparency and generalizability of CER using ECD. Findings are based on 6 exploratory site visits conducted under naturalistic inquiry in the spring of 2011. Themes, challenges, and innovations were identified in the visit summaries through coding, keyword searches, and review for complex concepts. : The identified overarching challenges and emerging opportunities include: the substantial level of effort to establish and sustain data sharing partnerships; the importance of understanding the strengths and limitations of clinical informatics tools, platforms, and models that have emerged to enable research with ECD; the need for rigorous methods to assess data validity, quality, and context for multisite studies; and, emerging opportunities to achieve meaningful patient and consumer engagement and work collaboratively with multidisciplinary teams. The new infrastructure must evolve to serve a diverse set of potential users and must scale to address a range of CER or patient-centered outcomes research (PCOR) questions. To achieve this aim-to improve the quality, transparency, and reproducibility of CER and PCOR-a high level of collaboration and support is necessary to foster partnership and best practices as part of the EDM Forum.

  9. Challenges in using electronic health record data for CER: experience of 4 learning organizations and solutions applied.

    Science.gov (United States)

    Bayley, K Bruce; Belnap, Tom; Savitz, Lucy; Masica, Andrew L; Shah, Nilay; Fleming, Neil S

    2013-08-01

    To document the strengths and challenges of using electronic health records (EHRs) for comparative effectiveness research (CER). A replicated case study of comparative effectiveness in hypertension treatment was conducted across 4 health systems, with instructions to extract data and document problems encountered using a specified list of required data elements. Researchers at each health system documented successes and challenges, and suggested solutions for addressing challenges. Data challenges fell into 5 categories: missing data, erroneous data, uninterpretable data, inconsistencies among providers and over time, and data stored in noncoded text notes. Suggested strategies to address these issues include data validation steps, use of surrogate markers, natural language processing, and statistical techniques. A number of EHR issues can hamper the extraction of valid data for cross-health system comparative effectiveness studies. Our case example cautions against a blind reliance on EHR data as a single definitive data source. Nevertheless, EHR data are superior to administrative or claims data alone, and are cheaper and timelier than clinical trials or manual chart reviews. All 4 participating health systems are pursuing pathways to more effectively use EHR data for CER.A partnership between clinicians, researchers, and information technology specialists is encouraged as a way to capitalize on the wealth of information contained in the EHR. Future developments in both technology and care delivery hold promise for improvement in the ability to use EHR data for CER.

  10. In-situ Transmission Electron Microscopy and Spectroscopy Studies of Interfaces in Li-ion Batteries: Challenges and Opportunities

    International Nuclear Information System (INIS)

    Wang, Chong M.; Xu, Wu; Liu, Jun; Choi, Daiwon; Arey, Bruce W.; Saraf, Laxmikant V.; Zhang, Jiguang; Yang, Zhenguo; Thevuthasan, Suntharampillai; Baer, Donald R.; Salmon, Norman

    2010-01-01

    The critical challenge facing the lithium ion battery development is the basic understanding of the structural evolution during the cyclic operation of the battery and the consequence of the structural evolution on the properties of the battery. Although transmission electron microscopy (TEM) and spectroscopy have been evolved to a stage such that it can be routinely used to probe into both the structural and chemical composition of the materials with a spatial resolution of a single atomic column, a direct in-situ TEM observation of structural evolution of the materials in lithium ion battery during the dynamic operation of the battery has never been reported. This is related to three factors: high vacuum operation of a TEM; electron transparency requirement of the region to be observed, and the difficulties dealing with the liquid electrolyte of lithium ion battery. In this paper, we report the results of exploring the in-situ TEM techniques for observation of the interface in lithium ion battery during the operation of the battery. A miniature battery was fabricated using a nanowire and an ionic liquid electrolyte. The structure and chemical composition of the interface across the anode and the electrolyte was studied using TEM imaging, electron diffraction, and electron energy loss spectroscopy. In addition, we also explored the possibilities of carrying out in-situ TEM studies of lithium ion batteries with a solid state electrolyte.

  11. The conversion to electronic hospital notes at Mayo Clinic. Overcoming barriers and challenges.

    Science.gov (United States)

    Andreen, Debra L; Dobie, Linda J; Jasperson, Jan C; Lucas, Thomas A; Wubbenhorst, Cathryn L

    2010-01-01

    This article describes the conversion to electronic hospital notes at a large, multi-specialty group practice: Mayo Clinic in Rochester, Minnesota. Because of the size of the institution and the barriers to the adoption of electronic notes, the process was a gradual one that took several years. Making a convincing case for change to institutional leaders and maintaining their support was crucial to success. Equally vital was the careful investigation of user requirements and the development of software features that allowed providers to complete their notes quickly in the fast-paced hospital environment. Care providers discovered the value of having immediate access to legible hospital notes throughout the campus and from remote locations.

  12. THE RELEVANCE OF ELECTRONIC COMMERCE FOR DURABLE DEVELOPMENT. CHALLENGES FOR ROMANIA

    OpenAIRE

    Assist. Ph.D Student Maruntelu Irina

    2009-01-01

    This article aims to approach the topic of the electronic commerce considering the context of the durable development, without exclusively limiting to the economic dimension of sustainable development. This paper aims to offer a vision on the e-commerce based on an optimistic approach of the reconciliation between economic growth and durable development, but moderate by the current realities (digital divide between countries/regions, economic crisis etc). Furthermore, by identifying some of t...

  13. Challenges of front-end and triggering electronics for High Granularity Calorimetry

    CERN Document Server

    Puljak, Ivica

    2017-01-01

    A high granularity calorimeter is presently being designed by the CMS Collaboration to replace the existing endcap detectors. It must be able to cope with the very high collision rates, imposing the development of novel filtering and triggering strategies, as well as with the harsh radiation environment of the high-luminosity LHC. In this paper we present an overview of the full electronics architecture and the performance of prototype components and algorithms.

  14. Electronic Cigarettes and Vaping: A New Challenge in Clinical Medicine and Public Health. A Literature Review

    OpenAIRE

    Palazzolo, Dominic L.

    2013-01-01

    Electronic cigarette (e-cigarette) use in the United States and worldwide is increasing. These devices closely mimic smoking of conventional cigarettes and can be used by consumers as a substitute for their smoking and nicotine addiction. Reasons for their popularity are that vendors of e-cigarettes have previously marketed their product as a safer alternative to conventional cigarettes, and as a possible smoking cessation tool. Rather than inhaling harmful smoke from burning tobacco, users o...

  15. Albuquerque/Middle Rio Grande Urban Waters Viewer

    Science.gov (United States)

    These data have been compiled in support of the Middle Rio Grande/Albuquerque Urban Waters Partnership for the region including Albuquerque, New Mexico.The Middle Rio Grande/Albuquerque Urban Waters Federal Partnership is co-chaired by the U.S. Dept. of Housing and Urban Development and the U.S. Environmental Protection Agency. There are also a number of other federal agencies engaged in projects with Tribal, State, and local officials, and community stakeholders. Like many western river ecosystems, the Middle Rio Grande faces numerous challenges in balancing competing needs within a finite water supply and other resource constrains. Historical practices by our ancestors and immigrants to the Middle Rio Grande have established the conditions that we have inherited. Long-term drought exacerbated by climate change is changing conditions that affect natural and human communities as we strive to improve our precious Rio Grande.The Middle Rio Grande/Albuquerque Urban Waters Federal Partnership will reconnect our urban communities, particularly those that are overburdened or economically distressed, with the waterway by improving coordination among federal agencies and collaborating with community-led revitalization efforts. Our projects will improve our community water systems and promote their economic, environmental and social benefits. Specifically, the Middle Rio Grande/Albuquerque Urban Waters Federal Partnership will support the development of the Valle de Oro

  16. Grand Fir Nutrient Management in the Inland Northwestern USA

    Directory of Open Access Journals (Sweden)

    Dennis R. Parent

    2016-11-01

    Full Text Available Grand fir (Abies grandis (Douglas ex D. Don Lindley is widely distributed in the moist forests of the Inland Northwest. It has high potential productivity, its growth being nearly equal to western white pine, the most productive species in the region. There are large standing volumes of grand fir in the region. Nutritionally, the species has higher foliage cation concentrations than associated conifers, especially potassium (K and calcium (Ca. In contrast, it has lower nitrogen (N foliage concentrations, which creates favorable nutrient balance on N-limited sites. Despite concentration differences, grand fir stores proportionally more nutrients per tree than associated species because of greater crown biomass. Although few fertilization trials have examined grand fir specifically, its response is inferred from its occurrence in many monitored mixed conifer stands. Fertilization trials including grand fir either as a major or minor component show that it has a strong diameter and height growth response ranging from 15% to 50% depending in part on site moisture availability and soil geology. Grand fir tends to have a longer response duration than other inland conifers. When executed concurrently with thinning, fertilization often increases the total response. Late rotation application of N provides solid investment returns in carefully selected stands. Although there are still challenges with the post-fertilization effects on tree mortality, grand fir will continue to be an important species with good economic values and beneficial responses to fertilization and nutrient management.

  17. Cassini's Grand Finale Overview

    Science.gov (United States)

    Spilker, L. J.

    2017-12-01

    After 13 years in orbit, the Cassini-Huygens Mission to Saturn ended in a science-rich blaze of glory. Cassini sent back its final bits of unique science data on September 15, 2017, as it plunged into Saturn's atmosphere, vaporizing and satisfying planetary protection requirements. Cassini's final phase covered roughly ten months and ended with the first time exploration of the region between the rings and planet. In late 2016 Cassini transitioned to a series of 20 Ring Grazing orbits with peripases just outside Saturn's F ring, providing close flybys of tiny ring moons, including Pan, Daphnis and Atlas, and high-resolution views of Saturn's A and F rings. A final Titan flyby in late April 2017 propelled Cassini across Saturn's main rings and into its Grand Finale orbits. Comprised of 22 orbits, Cassini repeatedly dove between Saturn's innermost rings and upper atmosphere to answer fundamental questions unattainable earlier in the mission. The last orbit turned the spacecraft into the first Saturn atmosphere probe. The Grand Finale orbits provided highest resolution observations of both the rings and Saturn, and in-situ sampling of the ring particle composition, Saturn's atmosphere, plasma, and innermost radiation belts. The gravitational field was measured to unprecedented accuracy, providing information on the interior structure of the planet, winds in the deeper atmosphere, and mass of the rings. The magnetic field provided insight into the physical nature of the magnetic dynamo and structure of the internal magnetic field. The ion and neutral mass spectrometer sampled the upper atmosphere for molecules that escape the atmosphere in addition to molecules originating from the rings. The cosmic dust analyzer directly sampled the composition from different parts of the main rings for the first time. Fields and particles instruments directly measured the plasma environment between the rings and planet. Science highlights and new mysteries collected in the Grand

  18. Grand unification and supergravity

    International Nuclear Information System (INIS)

    Nanopoulos, D.V.

    Grand Unified Theories (GUTs) are very successful, but they suffer from fine-tuning or hierarchy problems. It seems that more symmetry beyond the gauge symmetry is needed and indeed supersymmetric GUTs may provide the correct framework in solving the hierarchy problems. These are reviewed. From the results discussed, it is seen that for the first time in particle physics, gravity seems to play a dominant role. It may be responsible for GUT breaking, SU(2) x U(1) breaking, fermion masses, proton decay and a consistent cosmological picture. Supergravity seems to offer a consistent, effective theory for energies below the Planck scale to N=1 local SUSY but also, in the context of N=8 extended supergravity with a dynamically realized SU(8), there may be a consistent fundamental unified theory of all interactions. (U.K.)

  19. Grand unification: status report

    International Nuclear Information System (INIS)

    Georgi, H.

    1983-01-01

    Grand unification is reviewed with regard to the flavor puzzle and the hierarchy puzzle. Progress in CP and the PQWWKDFS axion is reviewed. The neutrino mass and B-L research, the understanding and assimilation of the language of effective theories (which divide the momentum scale up into regions), with focus on the models, are surveyed. Various unified models are organized according to whether they address the hierarchy puzzle or the flavor puzzle. SU(5), SO(10), E6, and Higgs are considered simple and explicit models. Global symmetry addresses hierarchy puzzle, but the rules are unclear. In SO (18), with regard to hierarchy, perturbation theory breaks down. SO (14) fails for hierarchy because of GIM, b and t problems. Supersymmetry and technicolor with regard to flavor puzzle are questioned. The CP solution of ETC and Composite C models (addressing both flavor and hierarchy) is a minus. Composite A model has no evident virtues, and the basic idea of ETC model needs checking

  20. Grand unified theories. Pt. 2

    International Nuclear Information System (INIS)

    Ellis, J.

    1982-01-01

    The author gives an introduction to the construction of grand unified theories on the base of the SU(3)xSU(2)xU(1) model of the strong, weak, and electromagnetic interactions. Especially he discusses the proton decay, neutrino masses and oscillations, and cosmological implications in connection with grand unified theories. (orig./HSI)

  1. La importancia de ser grande

    OpenAIRE

    Baisre, J. A.

    2007-01-01

    Se responde a las preguntas ¿por qué los mamíferos marinos son los animales más grandes del planeta?, ¿Por qué los peces no pueden ser más grandes?. Éstas y otras interrogantes son respondidas de forma sencilla y clara.

  2. Ultrafast Science Opportunities with Electron Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    DURR, HERMANN; Wang, X.J., ed.

    2016-04-28

    X-rays and electrons are two of the most fundamental probes of matter. When the Linac Coherent Light Source (LCLS), the world’s first x-ray free electron laser, began operation in 2009, it transformed ultrafast science with the ability to generate laser-like x-ray pulses from the manipulation of relativistic electron beams. This document describes a similar future transformation. In Transmission Electron Microscopy, ultrafast relativistic (MeV energy) electron pulses can achieve unsurpassed spatial and temporal resolution. Ultrafast temporal resolution will be the next frontier in electron microscopy and can ideally complement ultrafast x-ray science done with free electron lasers. This document describes the Grand Challenge science opportunities in chemistry, material science, physics and biology that arise from an MeV ultrafast electron diffraction & microscopy facility, especially when coupled with linac-based intense THz and X-ray pump capabilities.

  3. Overcoming Challenges in Kinetic Modeling of Magnetized Plasmas and Vacuum Electronic Devices

    Science.gov (United States)

    Omelchenko, Yuri; Na, Dong-Yeop; Teixeira, Fernando

    2017-10-01

    We transform the state-of-the art of plasma modeling by taking advantage of novel computational techniques for fast and robust integration of multiscale hybrid (full particle ions, fluid electrons, no displacement current) and full-PIC models. These models are implemented in 3D HYPERS and axisymmetric full-PIC CONPIC codes. HYPERS is a massively parallel, asynchronous code. The HYPERS solver does not step fields and particles synchronously in time but instead executes local variable updates (events) at their self-adaptive rates while preserving fundamental conservation laws. The charge-conserving CONPIC code has a matrix-free explicit finite-element (FE) solver based on a sparse-approximate inverse (SPAI) algorithm. This explicit solver approximates the inverse FE system matrix (``mass'' matrix) using successive sparsity pattern orders of the original matrix. It does not reduce the set of Maxwell's equations to a vector-wave (curl-curl) equation of second order but instead utilizes the standard coupled first-order Maxwell's system. We discuss the ability of our codes to accurately and efficiently account for multiscale physical phenomena in 3D magnetized space and laboratory plasmas and axisymmetric vacuum electronic devices.

  4. Challenges for embedded electronics in systems used in future facilities dedicated to international physics programs

    Energy Technology Data Exchange (ETDEWEB)

    Flament, O.; Bazzoli, S.; Girard, S.; Raimbourg, J.; Sauvestre, J. E. [CEA, DIF, F-91297 Arpajon (France); Baggio, J. [CEA, CESTA, F33830, Le Barp (France); Leray, J. L. [CEA, F-91191 Gif-sur-Yvette (France)

    2009-07-01

    The implementation of equipment with embedded electronic to monitor, control, measure and operate future large facilities dedicated to high energy physics or nuclear fusion are necessary. Reliable operation of these equipment will be achieved through availability and reliability analysis. In several cases, the equipment selection or development approach has to be done by considering a harsh environment in terms of radiations. In order to implement these systems in such environments shielding, location and distance from the source must be considered to reduce, to protect and to avoid radiation effects. People in charge of the choice of the equipment have to take into account and mitigate radiation effects from subsystem to system level. It is beyond the scope of this paper to address all the radiation effects: the electromagnetic effects are not dealt with. This paper is organised as follows: we describe the electronics and semiconductor trends in today applications, then we present the radiation effects and their impact on the device response and eventually we review different ways to mitigate these impacts

  5. Challenges for embedded electronics in systems used in future facilities dedicated to international physics programs

    International Nuclear Information System (INIS)

    Flament, O.; Bazzoli, S.; Girard, S.; Raimbourg, J.; Sauvestre, J. E.; Baggio, J.; Leray, J. L.

    2009-01-01

    The implementation of equipment with embedded electronic to monitor, control, measure and operate future large facilities dedicated to high energy physics or nuclear fusion are necessary. Reliable operation of these equipment will be achieved through availability and reliability analysis. In several cases, the equipment selection or development approach has to be done by considering a harsh environment in terms of radiations. In order to implement these systems in such environments shielding, location and distance from the source must be considered to reduce, to protect and to avoid radiation effects. People in charge of the choice of the equipment have to take into account and mitigate radiation effects from subsystem to system level. It is beyond the scope of this paper to address all the radiation effects: the electromagnetic effects are not dealt with. This paper is organised as follows: we describe the electronics and semiconductor trends in today applications, then we present the radiation effects and their impact on the device response and eventually we review different ways to mitigate these impacts

  6. Advance Care Planning Documentation in Electronic Health Records: Current Challenges and Recommendations for Change.

    Science.gov (United States)

    Lamas, Daniela; Panariello, Natalie; Henrich, Natalie; Hammes, Bernard; Hanson, Laura C; Meier, Diane E; Guinn, Nancy; Corrigan, Janet; Hubber, Sean; Luetke-Stahlman, Hannah; Block, Susan

    2018-04-01

    To develop a set of clinically relevant recommendations to improve the state of advance care planning (ACP) documentation in the electronic health record (EHR). Advance care planning (ACP) is a key process that supports goal-concordant care. For preferences to be honored, clinicians must be able to reliably record, find, and use ACP documentation. However, there are no standards to guide ACP documentation in the electronic health record (EHR). We interviewed 21 key informants to understand the strengths and weaknesses of EHR documentation systems for ACP and identify best practices. We analyzed these interviews using a qualitative content analysis approach and subsequently developed a preliminary set of recommendations. These recommendations were vetted and refined in a second round of input from a national panel of content experts. Informants identified six themes regarding current inadequacies in documentation and accessibility of ACP information and opportunities for improvement. We offer a set of concise, clinically relevant recommendations, informed by expert opinion, to improve the state of ACP documentation in the EHR.

  7. Qualitative analysis of round-table discussions on the business case and procurement challenges for hospital electronic prescribing systems.

    Directory of Open Access Journals (Sweden)

    Kathrin M Cresswell

    Full Text Available There is a pressing need to understand the challenges surrounding procurement of and business case development for hospital electronic prescribing systems, and to identify possible strategies to enhance the efficiency of these processes in order to assist strategic decision making.We organized eight multi-disciplinary round-table discussions in the United Kingdom. Participants included policy makers, representatives from hospitals, system developers, academics, and patients. Each discussion was digitally audio-recorded, transcribed verbatim and, together with accompanying field notes, analyzed thematically with NVivo9.We drew on data from 17 participants (approximately eight per roundtable, six hours of discussion, and 15 pages of field notes. Key challenges included silo planning with systems not being considered as part of an integrated organizational information technology strategy, lack of opportunity for interactions between customers and potential suppliers, lack of support for hospitals in choosing appropriate systems, difficulty of balancing structured planning with flexibility, and the on-going challenge of distinguishing "wants" and aspirations from organizational "needs".Development of business cases for major investments in information technology does not take place in an organizational vacuum. Building on previously identified potentially transferable dimensions to the development and execution of business cases surrounding measurements of costs/benefits and risk management, we have identified additional components relevant to ePrescribing systems. These include: considerations surrounding strategic context, case for change and objectives, future service requirements and options appraisal, capital and revenue implications, timescale and deliverability, and risk analysis and management.

  8. The front end electronics of the NA62 Gigatracker: challenges, design and experimental measurements

    Science.gov (United States)

    Noy, M.; Aglieri Rinella, G.; Ceccucci, A.; Dellacasa, G.; Fiorini, M.; Garbolino, S.; Jarron, P.; Kaplon, J.; Kluge, A.; Marchetto, F.; Martin, E.; Mazza, G.; Martoiu, S.; Morel, M.; Perktold, L.; Rivetti, A.; Tiuraniemi, S.

    2011-06-01

    The beam spectrometer of the NA62 experiment consists of 3 Gigatracker (GTK) stations. Each station comprises a pixel detector of 16 cm active area made of an assembly of 10 readout ASICs bump bonded to a 200 μm thick pixel silicon sensor, comprising 18000 pixels of 300 μm×300 μm. The main challenge of the NA62 pixel GTK station is the combination of an extremely high kaon/pion beam rate, where the intensity in the center of the beam reaches up to 1.5 Mhit s mm together with an extreme time resolution of 100 ps. To date, it is the first silicon tracking system with this time resolution. To face this challenge, the pixel analogue front end has been designed with a peaking time of 4 ns, with a planar silicon sensor operating up to 300 V over depletion. Moreover, the radiation level is severe, 2×10 1 MeV n cm per year of operation. Easy replacement of the GTK stations is foreseen as a design requirement. The amount of material of a single station should also be less than 0.5% X to minimize the background, which imposes strong constraints on the mechanics and the cooling system. We report upon the design and architecture of the 2 prototype demonstrator chips both designed in 130 nm CMOS technology, one with a constant fraction discriminator and the time stamp digitisation in each pixel (In-Pixel), and the other with a time-over-threshold discriminator and the processing of the time stamp located in the End of Column (EoC) region at the chip periphery. Some preliminary results are presented.

  9. Electronic Cigarettes and Vaping: A New Challenge in Clinical Medicine and Public Health.A Literature Review

    Directory of Open Access Journals (Sweden)

    Dominic L. Palazzolo

    2013-11-01

    Full Text Available Electronic cigarette (e-cigarette use in the United States and worldwide is increasing. These devices closely mimic smoking of conventional cigarettes and can be used by consumers as a substitute for their smoking and nicotine addiction. Reasons for their popularity are that vendors of e-cigarettes have previously marketed their product as a safer alternative to conventional cigarettes, and as a possible smoking cessation tool. Rather than inhaling harmful smoke from burning tobacco, users of electronic cigarettes inhale a potentially less harmful vaporized mist primarily consisting of propylene glycol, nicotine, and water in a process referred to as vaping. Furthermore, the e-cigarette web pages are full of anecdotal claims from ex-smokers on how e-cigarettes helped them to give up traditional cigarettes in favor of these electronic devices. Government agencies and the medical community are skeptical, indicating that there is not enough empirically-derived evidence to substantiate such claims. While vaping e-cigarettes appear to do very little to abate nicotine addiction, and almost certainly carry unknown potential dangers, its supporters believe it is a safer alternative to smoking cigarettes. However, before e-cigarettes and vaping can be considered as a viable harm reduction clinical approach to smoking cessation, the medical community must first face the challenges e-cigarettes and vaping present to public health. For example, what should the primary medical focus be for a patient who has successfully transitioned from conventional cigarettes to e-cigarettes? Should it be to maintain smoking abstinence or should it be to quit vaping? Would it not be prudent for a patient who is unwilling to quit smoking or to give up nicotine to vape instead of smoke? Given these circumstances, how should medical care providers advise their patients? To effectively face these challenges, health care professionals need to become more familiar with the

  10. Electronic cigarettes and thirdhand tobacco smoke: two emerging health care challenges for the primary care provider

    Directory of Open Access Journals (Sweden)

    Nidhi Mehrotra

    2011-02-01

    Full Text Available Ware G Kuschner, Sunayana Reddy, Nidhi Mehrotra, Harman S PaintalDivision of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Palo Alto, CA, USAAbstract: Primary care providers should be aware of two new developments in nicotine addiction and smoking cessation: 1 the emergence of a novel nicotine delivery system known as the electronic (e- cigarette; and 2 new reports of residual environmental nicotine and other biopersistent toxicants found in cigarette smoke, recently described as “thirdhand smoke”. The purpose of this article is to provide a clinician-friendly introduction to these two emerging issues so that clinicians are well prepared to counsel smokers about newly recognized health concerns relevant to tobacco use. E-cigarettes are battery powered devices that convert nicotine into a vapor that can be inhaled. The World Health Organization has termed these devices electronic nicotine delivery systems (ENDS. The vapors from ENDS are complex mixtures of chemicals, not pure nicotine. It is unknown whether inhalation of the complex mixture of chemicals found in ENDS vapors is safe. There is no evidence that e-cigarettes are effective treatment for nicotine addiction. ENDS are not approved as smoking cessation devices. Primary care givers should anticipate being questioned by patients about the advisability of using e-cigarettes as a smoking cessation device. The term thirdhand smoke first appeared in the medical literature in 2009 when investigators introduced the term to describe residual tobacco smoke contamination that remains after the cigarette is extinguished. Thirdhand smoke is a hazardous exposure resulting from cigarette smoke residue that accumulates in cars, homes, and other indoor spaces. Tobacco-derived toxicants can react to form potent cancer causing compounds. Exposure to thirdhand smoke can occur through the skin, by breathing, and by ingestion long after smoke has cleared from a room

  11. Prospects and Challenges in Application of Gamma and Electron Beam Processing of Nanomaterials

    International Nuclear Information System (INIS)

    Sampa, M. H.

    2006-01-01

    Application of radiation techniques for nanotechnology has been known for years. X-ray, EB and ion beam lithography are a good example of applications. By using electron beams, ion beams and X-Rays structures as small as 10 nm can be produced. Ion track membranes with track diameters from 10 nm to 100 nm are used as such or as templates for electroplating of nanowires of metal, semiconductor and magnetic materials. In the near future X-Rays, focused ion beams and electron beams will be used for nanolithography and 3D fabrication; heavy ion beams on the other hand can be useful for fabrication of nanopores and nanowires. The use of radiation has proved to be an essential technique in the fabrication of nanostructures with high resolution as the radiation beams can be focused into a few nanomater scales or less. Three groups of products could be considered to be fabricated by radiation techniques: nanoparticles, nanogels and nanocomposites. Nanoparticles has application in electronic devices and bioactive systems. Their radiation synthesis in aqueous dispersions started in the late seventies. Literature describe the radiolytic reduction of many metal ions either single metal or in combination with another metal to generate metallic or bimetallic mixtures as well as core-shell structures. To obtain metallic particles from their parent ions one only needs to ensure reductive conditions during the irradiation. By control over the dose rate delivered to the sample the radiolytic approach can offer the fine control over the rate of generation on the growing species. Nanogels are particles of polymer gels having the dimensions in the order of nanometers. They are applied in pharmaceutical and cosmetic industries, as the bioactive substances delivery systems. Depending on the irradiation parameters (radiation dose, dose rate, polymer concentration, irradiation temperature) molecules with different structures (such as long-chain branches, nanogels, microgel or microgel

  12. Challenge of engaging all students via self-paced interactive electronic learning tutorials for introductory physics

    Science.gov (United States)

    DeVore, Seth; Marshman, Emily; Singh, Chandralekha

    2017-06-01

    As research-based, self-paced electronic learning tools become increasingly available, a critical issue educators encounter is implementing strategies to ensure that all students engage with them as intended. Here, we first discuss the effectiveness of electronic learning tutorials as self-paced learning tools in large enrollment brick and mortar introductory physics courses and then propose a framework for helping students engage effectively with the learning tools. The tutorials were developed via research in physics education and were found to be effective for a diverse group of introductory physics students in one-on-one implementation. Instructors encouraged the use of these tools in a self-paced learning environment by telling students that they would be helpful for solving the assigned homework problems and that the underlying physics principles in the tutorial problems would be similar to those in the in-class quizzes (which we call paired problems). We find that many students in the courses in which these interactive electronic learning tutorials were assigned as a self-study tool performed poorly on the paired problems. In contrast, a majority of student volunteers in one-on-one implementation greatly benefited from the tutorials and performed well on the paired problems. The significantly lower overall performance on paired problems administered as an in-class quiz compared to the performance of student volunteers who used the research-based tutorials in one-on-one implementation suggests that many students enrolled in introductory physics courses did not effectively engage with the tutorials outside of class and may have only used them superficially. The findings suggest that many students in need of out-of-class remediation via self-paced learning tools may have difficulty motivating themselves and may lack the self-regulation and time-management skills to engage effectively with tools specially designed to help them learn at their own pace. We

  13. Challenge of engaging all students via self-paced interactive electronic learning tutorials for introductory physics

    Directory of Open Access Journals (Sweden)

    Seth DeVore

    2017-05-01

    Full Text Available As research-based, self-paced electronic learning tools become increasingly available, a critical issue educators encounter is implementing strategies to ensure that all students engage with them as intended. Here, we first discuss the effectiveness of electronic learning tutorials as self-paced learning tools in large enrollment brick and mortar introductory physics courses and then propose a framework for helping students engage effectively with the learning tools. The tutorials were developed via research in physics education and were found to be effective for a diverse group of introductory physics students in one-on-one implementation. Instructors encouraged the use of these tools in a self-paced learning environment by telling students that they would be helpful for solving the assigned homework problems and that the underlying physics principles in the tutorial problems would be similar to those in the in-class quizzes (which we call paired problems. We find that many students in the courses in which these interactive electronic learning tutorials were assigned as a self-study tool performed poorly on the paired problems. In contrast, a majority of student volunteers in one-on-one implementation greatly benefited from the tutorials and performed well on the paired problems. The significantly lower overall performance on paired problems administered as an in-class quiz compared to the performance of student volunteers who used the research-based tutorials in one-on-one implementation suggests that many students enrolled in introductory physics courses did not effectively engage with the tutorials outside of class and may have only used them superficially. The findings suggest that many students in need of out-of-class remediation via self-paced learning tools may have difficulty motivating themselves and may lack the self-regulation and time-management skills to engage effectively with tools specially designed to help them learn at their

  14. Electronic Paramagnetic Resonance of irradiated nails: challenges for a dosimetry in radiation accidents

    International Nuclear Information System (INIS)

    Giannoni, Ricardo A.; Rodrigues Junior, Orlando

    2014-01-01

    The purpose of this work is to characterize samples of human nails exposed to high doses of radiation, applying the technique of Electron Paramagnetic Resonance (EPR). The objective is to establish a dose response study that allow determine the absorbed dose by exposed individuals in situations of radiological accidents, in a retrospective form. Samples of human nails were collected and afterward irradiated with gamma radiation, and received dose of 20 Gy. The EPR measurement performed on the samples, before irradiation, permitted the signal identification of the components associated with effects caused by the mechanical stress during the fingernail cutting, the so-called mechanically induced signal (MIS). After the irradiation, different species of free radicals were identified, the so-called radiation induced signal (RIS). (author)

  15. Electronic cigarettes and thirdhand tobacco smoke: two emerging health care challenges for the primary care provider.

    Science.gov (United States)

    Kuschner, Ware G; Reddy, Sunayana; Mehrotra, Nidhi; Paintal, Harman S

    2011-02-01

    PRIMARY CARE PROVIDERS SHOULD BE AWARE OF TWO NEW DEVELOPMENTS IN NICOTINE ADDICTION AND SMOKING CESSATION: 1) the emergence of a novel nicotine delivery system known as the electronic (e-) cigarette; and 2) new reports of residual environmental nicotine and other biopersistent toxicants found in cigarette smoke, recently described as "thirdhand smoke". The purpose of this article is to provide a clinician-friendly introduction to these two emerging issues so that clinicians are well prepared to counsel smokers about newly recognized health concerns relevant to tobacco use. E-cigarettes are battery powered devices that convert nicotine into a vapor that can be inhaled. The World Health Organization has termed these devices electronic nicotine delivery systems (ENDS). The vapors from ENDS are complex mixtures of chemicals, not pure nicotine. It is unknown whether inhalation of the complex mixture of chemicals found in ENDS vapors is safe. There is no evidence that e-cigarettes are effective treatment for nicotine addiction. ENDS are not approved as smoking cessation devices. Primary care givers should anticipate being questioned by patients about the advisability of using e-cigarettes as a smoking cessation device. The term thirdhand smoke first appeared in the medical literature in 2009 when investigators introduced the term to describe residual tobacco smoke contamination that remains after the cigarette is extinguished. Thirdhand smoke is a hazardous exposure resulting from cigarette smoke residue that accumulates in cars, homes, and other indoor spaces. Tobacco-derived toxicants can react to form potent cancer causing compounds. Exposure to thirdhand smoke can occur through the skin, by breathing, and by ingestion long after smoke has cleared from a room. Counseling patients about the hazards of thirdhand smoke may provide additional motivation to quit smoking.

  16. Geo synthetics. a remarkable discipline with great achievements in the past and exciting challenges for a bright future; Geosinteticos: una importante disciplina con grandes logros en el pasado y emocionantes retos para un brillante futuro

    Energy Technology Data Exchange (ETDEWEB)

    Giroud, J. P.

    2014-02-01

    This paper presents achievements of the geo synthetics discipline and challenges facing the discipline. The paper shows that one of the main achievements of geo synthetics discipline and challenges facing the discipline. The paper shows that one of the main achievements of geo synthetics is that they have pervaded most branches of geotechnical engineering to the point where it is almost impossible to practice geotechnical engineering without geo synthetics. Then, the paper addresses the challenges facing the geo synthetics discipline. Two major types of challenges are identified: education challenges and technical challenges. Regarding technical challenges, it is recommended that researchers focus on behaviors that are not traditionally considered in geotechnical engineering in order to use geo synthetics to their full potential. Note: this is a significantly expanded version of the keynote paper presented at the 2008 GeoAmericas Conferences. (Author)

  17. Mind the Gap. A systematic review to identify usability and safety challenges and practices during electronic health record implementation.

    Science.gov (United States)

    Ratwani, Raj; Fairbanks, Terry; Savage, Erica; Adams, Katie; Wittie, Michael; Boone, Edna; Hayden, Andrew; Barnes, Janey; Hettinger, Zach; Gettinger, Andrew

    2016-11-16

    Decisions made during electronic health record (EHR) implementations profoundly affect usability and safety. This study aims to identify gaps between the current literature and key stakeholders' perceptions of usability and safety practices and the challenges encountered during the implementation of EHRs. Two approaches were used: a literature review and interviews with key stakeholders. We performed a systematic review of the literature to identify usability and safety challenges and best practices during implementation. A total of 55 articles were reviewed through searches of PubMed, Web of Science and Scopus. We used a qualitative approach to identify key stakeholders' perceptions; semi-structured interviews were conducted with a diverse set of health IT stakeholders to understand their current practices and challenges related to usability during implementation. We used a grounded theory approach: data were coded, sorted, and emerging themes were identified. Conclusions from both sources of data were compared to identify areas of misalignment. We identified six emerging themes from the literature and stakeholder interviews: cost and resources, risk assessment, governance and consensus building, customization, clinical workflow and usability testing, and training. Across these themes, there were misalignments between the literature and stakeholder perspectives, indicating major gaps. Major gaps identified from each of six emerging themes are discussed as critical areas for future research, opportunities for new stakeholder initiatives, and opportunities to better disseminate resources to improve the implementation of EHRs. Our analysis identified practices and challenges across six different emerging themes, illustrated important gaps, and results suggest critical areas for future research and dissemination to improve EHR implementation.

  18. Electronic mail communication between physicians and patients: a review of challenges and opportunities.

    Science.gov (United States)

    Antoun, Jumana

    2016-04-01

    Although promising benefits hold for email communication between physicians and patients in terms of lowering the costs of health care while maintaining or improving the quality of disease management and health promotion, physician use of email with patients is still low and lags behind the willingness of patients to communicate with their physicians through email. There is also a discrepancy between physicians' willingness and actual practice of email communication. Several factors may explain these discrepancies. They include physicians differ in their experience and attitude towards information technology; some may not be convinced that patients appreciate, need and can communicate by email with their doctors; others are still waiting for robust evidence on service performance and efficiency in addition to patient satisfaction and outcome that support such practice; and many are reluctant to do so because of perceived barriers. This report is a review of the literature on the readiness for and adoption of physician-patient email communication, and how can challenges be or have been addressed. The need for Governmental support and directives for email communication to move forward is iterated, and opportunities for future research are pointed out. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. Grand slam on cancer.

    Science.gov (United States)

    Gartrell, Nanette

    2014-01-01

    A winner of 59 Grand Slam championships including a record 9 Wimbledon singles titles, Martina Navratilova is the most successful woman tennis player of the modern era. Martina was inducted into the International Tennis Hall of Fame, named "Tour Player of the Year" seven times by the Women's Tennis Association, declared "Female Athlete of the Year" by the Associated Press, and ranked one of the "Top Forty Athletes of All-Time" by Sports Illustrated. Equally accomplished off the court, Martina is an author, philanthropist, TV commentator, and activist who has dedicated her life to educating people about prejudice and stereotypes. After coming out as a lesbian in 1981, Martina became a tireless advocate of equal rights for lesbian, gay, bisexual, and transgender (LGBT) people, and she has contributed generously to the LGBT community. Martina is the author of seven books, including most recently Shape Your Self: My 6-Step Diet and Fitness Plan to Achieve the Best Shape of your Life, an inspiring guide to healthy living and personal fitness. Martina was diagnosed with breast cancer in 2010.

  20. Magnetic spectrometer Grand Raiden

    International Nuclear Information System (INIS)

    Fujiwara, M.; Akimune, H.; Daito, I.; Fujimura, H.; Fujita, Y.; Hatanaka, K.; Ikegami, H.; Katayama, I.; Nagayama, K.; Matsuoka, N.; Morinobu, S.; Noro, T.; Yoshimura, M.; Sakaguchi, H.; Sakemi, Y.; Tamii, A.; Yosoi, M.

    1999-01-01

    A high-resolution magnetic spectrometer called 'Grand Raiden' is operated at the RCNP ring cyclotron facility in Osaka for nuclear physics studies at intermediate energies. This magnetic spectrometer has excellent ion-optical properties. In the design of the spectrometer, the second-order dispersion matching condition has been taken into account, and almost all the aberration terms such as (x vertical bar θ 3 ), (x vertical bar θφ 2 ), (x vertical bar θ 2 δ) and (x vertical bar θδ 2 ) in a third-order matrix calculation are optimized. A large magnetic rigidity of the spectrometer (K = 1400 MeV) gives a great advantage to measure the charge-exchange ( 3 He, t) reactions at 450 MeV. The ability of the high-resolution measurement has been demonstrated. Various coincidence measurements are performed to study the nuclear structures of highly excited states through decay properties of nuclear levels following nuclear reactions at intermediate energies

  1. Clinical physiology grand rounds.

    Science.gov (United States)

    Richards, Jeremy; Schwartzstein, Richard; Irish, Julie; Almeida, Jacqueline; Roberts, David

    2013-04-01

    Clinical Physiology Grand Rounds (CPGR) is an interactive, case-based conference for medical students designed to: (1) integrate preclinical and clinical learning; (2) promote inductive clinical reasoning; and (3) emphasise students as peer teachers. CPGR specifically encourages mixed learning level student interactions and emphasises the use of concept mapping. We describe the theoretical basis and logistical considerations for an interactive, integrative, mixed-learner environment such as CPGR. In addition, we report qualitative data regarding students' attitudes towards and perceptions of CPGR. Medical students from first to fourth year participate in a monthly, interactive conference. The CPGR was designed to bridge gaps and reinforce linkages between basic science and clinical concepts, and to incorporate interactive vertical integration between preclinical and clinical students. Medical education and content experts use Socratic, interactive teaching methods to develop real-time concept maps to emphasise the presence and importance of linkages across curricula. Student focus groups were held to assess attitudes towards and perceptions of the mixed-learner environment and concept maps in CPGR. Qualitative analyses of focus group transcripts were performed to develop themes and codes describing the students' impressions of CPGR. CPGR is a case-based, interactive conference designed to help students gain an increased appreciation of linkages between basic science and clinical medicine concepts, and an increased awareness of clinical reasoning thought processes. Success is dependent upon explicit attention being given to goals for students' integrated learning. © Blackwell Publishing Ltd 2013.

  2. Assessing electronic cigarette effects and regulatory impact: Challenges with user self-reported device power.

    Science.gov (United States)

    Rudy, Alyssa K; Leventhal, Adam M; Goldenson, Nicholas I; Eissenberg, Thomas

    2017-10-01

    Electronic cigarettes (ECIGs) aerosolize liquids for user inhalation that usually contain nicotine. ECIG nicotine emission is determined, in part, by user behavior, liquid nicotine concentration, and electrical power. Whether users are able to report accurately nicotine concentration and device electrical power has not been evaluated. This study's purpose was to examine if ECIG users could provide data relevant to understanding ECIG nicotine emission, particularly liquid nicotine concentration (mg/ml) as well as battery voltage (V) and heater resistance (ohms, Ω) - needed to calculate power (watts, W). Adult ECIG users (N=165) were recruited from Los Angeles, CA for research studies examining the effects of ECIG use. We asked all participants who visited the laboratory to report liquid nicotine concentration, V, and Ω. Liquid nicotine concentration was reported by 89.7% (mean=9.5mg/ml, SD=7.3), and responses were consistent with the distribution of liquids available in commonly marketed products. The majority could not report voltage (51.5%) or resistance (63.6%). Of the 40 participants (24.8%) who reported voltage and resistance, there was a substantial power range (2.2-32,670W) the upper limit of which exceeds that of the highest ECIG reported by any user to our knowledge (i.e., 2512W). If 2512W is taken as the upper limit, only 30 (18.2%) reported valid results (mean 237.3W, SD=370.6; range=2.2-1705.3W). Laboratory, survey, and other researchers interested in understanding ECIG effects to inform users and policymakers may need to use methods other than user self-report to obtain information regarding device power. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Packaging Technologies for 500 C SiC Electronics and Sensors: Challenges in Material Science and Technology

    Science.gov (United States)

    Chen, Liang-Yu; Neudeck, Philip G.; Behelm, Glenn M.; Spry, David J.; Meredith, Roger D.; Hunter, Gary W.

    2015-01-01

    This paper presents ceramic substrates and thick-film metallization based packaging technologies in development for 500C silicon carbide (SiC) electronics and sensors. Prototype high temperature ceramic chip-level packages and printed circuit boards (PCBs) based on ceramic substrates of aluminum oxide (Al2O3) and aluminum nitride (AlN) have been designed and fabricated. These ceramic substrate-based chip-level packages with gold (Au) thick-film metallization have been electrically characterized at temperatures up to 550C. The 96 alumina packaging system composed of chip-level packages and PCBs has been successfully tested with high temperature SiC discrete transistor devices at 500C for over 10,000 hours. In addition to tests in a laboratory environment, a SiC junction field-effect-transistor (JFET) with a packaging system composed of a 96 alumina chip-level package and an alumina printed circuit board was tested on low earth orbit for eighteen months via a NASA International Space Station experiment. In addition to packaging systems for electronics, a spark-plug type sensor package based on this high temperature interconnection system for high temperature SiC capacitive pressure sensors was also developed and tested. In order to further significantly improve the performance of packaging system for higher packaging density, higher operation frequency, power rating, and even higher temperatures, some fundamental material challenges must be addressed. This presentation will discuss previous development and some of the challenges in material science (technology) to improve high temperature dielectrics for packaging applications.

  4. Electronic Currency in the Light of Modern Legal and Economic Challenges

    Directory of Open Access Journals (Sweden)

    Olga А. Nikolaychuk

    2017-03-01

    Full Text Available The author gives a brief excursus on the crypto-currency development, the theoretical understanding of a new kind of digital money. Today in the world there is no single interpretation of the crypto-currency, in some sources it is treated as a currency, others as a commodity or raw material. The appearance and use of Bitcoin (the main crypto-currency are considered by some authors as the evolution of the global financial system. The history of the crypto-currency origin, the distinctive features of cryptocurrency from the usual currency, the specifics of their use and relation to these governments are investigated and characterized by their legal status. There are real limitations in Australia, Germany, the Netherlands, New Zealand, Singapore, some US States and various offshore, they might constitute restrictive measures, as in Indonesia, China, Russia, and Ukraine. Many governments chose a wait – for example, the EU, UK, Switzerland, USA, Canada, Japan, countries of South-East Asia. The most significant signs of cryptocurrencies, such as decentralization, anonymity and lack of guarantees are marked. Two possible scenarios of crypto-currency development in Russia are proposed. The first scenario is prohibitive and the second one is regulatory. It is noted that the bitcoin should be banned, and should be studied, and then start to gradually adjust. Its benefits and disadvantages of the scenario use are highlighted. In addition, the author emphases the almost complete lack of a legal framework governing relations between clients of the new information network. As a result the study is focused not only on the necessity a detailed scientific study of crypto-currencies, but also on the need to develop institutional norms. Most of the developed countries adapt their legislation to regulate the new electronic money, which will allow slow to adapt innovation of the financial market - a crypto-currency to modern realities. As in Russia the legal basis

  5. Qualitative Analysis of Round-Table Discussions on the Business Case and Procurement Challenges for Hospital Electronic Prescribing Systems

    Science.gov (United States)

    Cresswell, Kathrin M.; Slee, Ann; Coleman, Jamie; Williams, Robin; Bates, David W.; Sheikh, Aziz

    2013-01-01

    Objectives There is a pressing need to understand the challenges surrounding procurement of and business case development for hospital electronic prescribing systems, and to identify possible strategies to enhance the efficiency of these processes in order to assist strategic decision making. Materials and Methods We organized eight multi-disciplinary round-table discussions in the United Kingdom. Participants included policy makers, representatives from hospitals, system developers, academics, and patients. Each discussion was digitally audio-recorded, transcribed verbatim and, together with accompanying field notes, analyzed thematically with NVivo9. Results We drew on data from 17 participants (approximately eight per roundtable), six hours of discussion, and 15 pages of field notes. Key challenges included silo planning with systems not being considered as part of an integrated organizational information technology strategy, lack of opportunity for interactions between customers and potential suppliers, lack of support for hospitals in choosing appropriate systems, difficulty of balancing structured planning with flexibility, and the on-going challenge of distinguishing “wants” and aspirations from organizational “needs”. Discussion and conclusions Development of business cases for major investments in information technology does not take place in an organizational vacuum. Building on previously identified potentially transferable dimensions to the development and execution of business cases surrounding measurements of costs/benefits and risk management, we have identified additional components relevant to ePrescribing systems. These include: considerations surrounding strategic context, case for change and objectives, future service requirements and options appraisal, capital and revenue implications, timescale and deliverability, and risk analysis and management. PMID:24260213

  6. The CBM Experiment at FAIR-New challenges for Front-End Electronics, Data Acquisition and Trigger Systems

    International Nuclear Information System (INIS)

    Mueller, Walter F J

    2006-01-01

    The 'Compressed Baryonic Matter' (CBM) experiment at the new 'Facility for Antiproton and Ion Research' (FAIR) in Darmstadt is designed to study the properties of highly compressed baryonic matter produced in nucleus-nucleus collisions in the 10 to 45 A GeV energy range. One of the key observables is hidden (J/ψ) and open (D 0 , D ± ) charm production. To achieve an adequate sensitivity extremely high interaction rates of up to 10 7 events/second are required, resulting in major technological challenges for the detectors, front-end electronics and data processing. The front-end electronics will be self-triggered, autonomously detect particle hits, and output hit parameter together with a precise absolute time-stamp. Several layers of feature extraction and event selection will reduce the primary data flow of about 1 TByte/sec to a level of 1 GByte/sec. This new architecture avoids many limitations of conventional DAQ/Trigger systems and is for example essential for open charm detection, which requires the reconstruction of displaced vertices, in a high-rate heavy ion environment

  7. Electronic coarse graining enhances the predictive power of molecular simulation allowing challenges in water physics to be addressed

    Energy Technology Data Exchange (ETDEWEB)

    Cipcigan, Flaviu S., E-mail: flaviu.cipcigan@ed.ac.uk [School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh EH9 3FD (United Kingdom); National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW (United Kingdom); Sokhan, Vlad P. [National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW (United Kingdom); Crain, Jason [School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh EH9 3FD (United Kingdom); National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW (United Kingdom); Martyna, Glenn J. [IBM T. J. Watson Research Center, Yorktown Heights, NY 10598 (United States)

    2016-12-01

    One key factor that limits the predictive power of molecular dynamics simulations is the accuracy and transferability of the input force field. Force fields are challenged by heterogeneous environments, where electronic responses give rise to biologically important forces such as many-body polarisation and dispersion. The importance of polarisation in the condensed phase was recognised early on, as described by Cochran in 1959 [Philosophical Magazine 4 (1959) 1082–1086] [32]. Currently in molecular simulation, dispersion forces are treated at the two-body level and in the dipole limit, although the importance of three-body terms in the condensed phase was demonstrated by Barker in the 1980s [Phys. Rev. Lett. 57 (1986) 230–233] [72]. One approach for treating both polarisation and dispersion on an equal basis is to coarse grain the electrons surrounding a molecular moiety to a single quantum harmonic oscillator (cf. Hirschfelder, Curtiss and Bird 1954 [The Molecular Theory of Gases and Liquids (1954)] [37]). The approach, when solved in strong coupling beyond the dipole limit, gives a description of long-range forces that includes two- and many-body terms to all orders. In the last decade, the tools necessary to implement the strong coupling limit have been developed, culminating in a transferable model of water with excellent predictive power across the phase diagram. Transferability arises since the environment automatically identifies the important long range interactions, rather than the modeler through a limited set of expressions. Here, we discuss the role of electronic coarse-graining in predictive multiscale materials modelling and describe the first implementation of the method in a general purpose molecular dynamics software: QDO-MD. - Highlights: • Electronic coarse graining unites many-body dispersion and polarisation beyond the dipole limit. • It consists of replacing the electrons of a molecule using a quantum harmonic oscillator, called a

  8. Electronic coarse graining enhances the predictive power of molecular simulation allowing challenges in water physics to be addressed

    International Nuclear Information System (INIS)

    Cipcigan, Flaviu S.; Sokhan, Vlad P.; Crain, Jason; Martyna, Glenn J.

    2016-01-01

    One key factor that limits the predictive power of molecular dynamics simulations is the accuracy and transferability of the input force field. Force fields are challenged by heterogeneous environments, where electronic responses give rise to biologically important forces such as many-body polarisation and dispersion. The importance of polarisation in the condensed phase was recognised early on, as described by Cochran in 1959 [Philosophical Magazine 4 (1959) 1082–1086] [32]. Currently in molecular simulation, dispersion forces are treated at the two-body level and in the dipole limit, although the importance of three-body terms in the condensed phase was demonstrated by Barker in the 1980s [Phys. Rev. Lett. 57 (1986) 230–233] [72]. One approach for treating both polarisation and dispersion on an equal basis is to coarse grain the electrons surrounding a molecular moiety to a single quantum harmonic oscillator (cf. Hirschfelder, Curtiss and Bird 1954 [The Molecular Theory of Gases and Liquids (1954)] [37]). The approach, when solved in strong coupling beyond the dipole limit, gives a description of long-range forces that includes two- and many-body terms to all orders. In the last decade, the tools necessary to implement the strong coupling limit have been developed, culminating in a transferable model of water with excellent predictive power across the phase diagram. Transferability arises since the environment automatically identifies the important long range interactions, rather than the modeler through a limited set of expressions. Here, we discuss the role of electronic coarse-graining in predictive multiscale materials modelling and describe the first implementation of the method in a general purpose molecular dynamics software: QDO-MD. - Highlights: • Electronic coarse graining unites many-body dispersion and polarisation beyond the dipole limit. • It consists of replacing the electrons of a molecule using a quantum harmonic oscillator, called a

  9. Electronic coarse graining enhances the predictive power of molecular simulation allowing challenges in water physics to be addressed

    Science.gov (United States)

    Cipcigan, Flaviu S.; Sokhan, Vlad P.; Crain, Jason; Martyna, Glenn J.

    2016-12-01

    One key factor that limits the predictive power of molecular dynamics simulations is the accuracy and transferability of the input force field. Force fields are challenged by heterogeneous environments, where electronic responses give rise to biologically important forces such as many-body polarisation and dispersion. The importance of polarisation in the condensed phase was recognised early on, as described by Cochran in 1959 [Philosophical Magazine 4 (1959) 1082-1086] [32]. Currently in molecular simulation, dispersion forces are treated at the two-body level and in the dipole limit, although the importance of three-body terms in the condensed phase was demonstrated by Barker in the 1980s [Phys. Rev. Lett. 57 (1986) 230-233] [72]. One approach for treating both polarisation and dispersion on an equal basis is to coarse grain the electrons surrounding a molecular moiety to a single quantum harmonic oscillator (cf. Hirschfelder, Curtiss and Bird 1954 [The Molecular Theory of Gases and Liquids (1954)] [37]). The approach, when solved in strong coupling beyond the dipole limit, gives a description of long-range forces that includes two- and many-body terms to all orders. In the last decade, the tools necessary to implement the strong coupling limit have been developed, culminating in a transferable model of water with excellent predictive power across the phase diagram. Transferability arises since the environment automatically identifies the important long range interactions, rather than the modeller through a limited set of expressions. Here, we discuss the role of electronic coarse-graining in predictive multiscale materials modelling and describe the first implementation of the method in a general purpose molecular dynamics software: QDO_MD.

  10. Mobile Device-Based Electronic Data Capture System Used in a Clinical Randomized Controlled Trial: Advantages and Challenges.

    Science.gov (United States)

    Zhang, Jing; Sun, Lei; Liu, Yu; Wang, Hongyi; Sun, Ningling; Zhang, Puhong

    2017-03-08

    Electronic data capture (EDC) systems have been widely used in clinical research, but mobile device-based electronic data capture (mEDC) system has not been well evaluated. The aim of our study was to evaluate the feasibility, advantages, and challenges of mEDC in data collection, project management, and telemonitoring in a randomized controlled trial (RCT). We developed an mEDC to support an RCT called "Telmisartan and Hydrochlorothiazide Antihypertensive Treatment (THAT)" study, which was a multicenter, double-blinded, RCT, with the purpose of comparing the efficacy of telmisartan and hydrochlorothiazide (HCTZ) monotherapy in high-sodium-intake patients with mild to moderate hypertension during a 60 days follow-up. Semistructured interviews were conducted during and after the trial to evaluate the feasibility, advantage, and challenge of mEDC. Nvivo version 9.0 (QSR International) was used to analyze records of interviews, and a thematic framework method was used to obtain outcomes. The mEDC was successfully used to support the data collection and project management in all the 14 study hospitals. A total of 1333 patients were recruited with support of mEDC, of whom 1037 successfully completed all 4 visits. Across all visits, the average time needed for 141 questions per patient was 53 min, which were acceptable to both doctors and patients. All the interviewees, including 24 doctors, 53 patients, 1 clinical research associate (CRA), 1 project manager (PM), and 1 data manager (DM), expressed their satisfaction to nearly all the functions of the innovative mEDC in randomization, data collection, project management, quality control, and remote monitoring in real time. The average satisfaction score was 9.2 (scale, 0-10). The biggest challenge came from the stability of the mobile or Wi-Fi signal although it was not a problem in THAT study. The innovative mEDC has many merits and is well acceptable in supporting data collection and project management in a timely

  11. Imaging mass spectrometry tackles interfacial challenges in electrochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Xiao-Ying

    2017-12-01

    Electrochemistry has played a significant role in many research fields. Owing to its sensitivity and selectivity, in situ electroanalysis has been widely used as a fast and economical means for achieving outstanding results. Although many spectroscopic techniques have been used in electrochemistry, the challenges to capture short-lived intermediate species as a result of electron transfer in the buried solid electrode and electrolyte solution interface remains a grand challenge. In situ imaging mass spectrometry (IMS) recently has been extended to capture transient species in electrochemistry. This review intends to summarize newest development of IMS and its applications in advancing fundamental electrochemistry.

  12. Sequential Pattern Mining of Electronic Healthcare Reimbursement Claims: Experiences and Challenges in Uncovering How Patients are Treated by Physicians

    Energy Technology Data Exchange (ETDEWEB)

    Pullum, Laura L [ORNL; Ramanathan, Arvind [ORNL; Hobson, Tanner C [ORNL

    2015-01-01

    We examine the use of electronic healthcare reimbursement claims (EHRC) for analyzing healthcare delivery and practice patterns across the United States (US). We show that EHRCs are correlated with disease incidence estimates published by the Centers for Disease Control. Further, by analyzing over 1 billion EHRCs, we track patterns of clinical procedures administered to patients with autism spectrum disorder (ASD), heart disease (HD) and breast cancer (BC) using sequential pattern mining algorithms. Our analyses reveal that in contrast to treating HD and BC, clinical procedures for ASD diagnoses are highly varied leading up to and after the ASD diagnoses. The discovered clinical procedure sequences also reveal significant differences in the overall costs incurred across different parts of the US, indicating a lack of consensus amongst practitioners in treating ASD patients. We show that a data-driven approach to understand clinical trajectories using EHRC can provide quantitative insights into how to better manage and treat patients. Based on our experience, we also discuss emerging challenges in using EHRC datasets for gaining insights into the state of contemporary healthcare delivery and practice in the US.

  13. Investigation Procedures in Terrorist Electronic Crimes and it’s Challenges: A study in the Saudi legal system

    Directory of Open Access Journals (Sweden)

    Nehad Farouk Abbas Mohamed

    2015-05-01

    Full Text Available Rapid advances in information technology (IT form the backbone of the development of everyday life and a knowledge-based society. At present, there is more and more attention being paid to IT because of its extensive use in all spheres of life. Due to this massive cyber development, new type of crimes with complex and multifaceted nature have evolved. This is in contrast to traditional crimes from all angles, whether security or geographical based. Due to this, a number of challenges and dangers or threatening specialist judicial authorities and hamper their work and technical abilities in performing the tasks entrusted to them, particularly in crime investigation and prosecution. Because of the complex nature and detailed technical procedures applied at each stage of crime investigation, much greater efforts are required to reveal the hidden realities of an electronic crime. Therefore, investigation authorities, judiciary and other relevant bodies require an up to date knowledge of new technologies to be able to perform their allocated tasks precisely according to defined rules and regulations, and identify the perpetrator correctly.

  14. Digital Savings: A Study of Academic Libraries Finds that Going from Print to Electronic Journals Can Save Money, if It's Done Right, but Challenges Remain

    Science.gov (United States)

    Schonfeld, Roger C.; Fenton, Eileen Gifford

    2005-01-01

    Without question, the ongoing transition from print to electronic periodicals has challenged librarians to rethink their strategies. While some effects of this change have been immediately apparent--greater breadth of material, easier access, exposure to new sources, publisher package deals, and open access--the broader outcomes on library…

  15. SO(10) supersymmetric grand unified theories

    Science.gov (United States)

    Dermisek, Radovan

    The origin of the fermion mass hierarchy is one of the most challenging problems in elementary particle physics. In the standard model fermion masses and mixing angles are free parameters. Supersymmetric grand unified theories provide a beautiful framework for physics beyond the standard model. In addition to gauge coupling unification these theories provide relations between quark and lepton masses within families, and with additional family symmetry the hierarchy between families can be generated. We present a predictive SO(10) supersymmetric grand unified model with D 3 x U(1) family symmetry. The hierarchy in fermion masses is generated by the family symmetry breaking D 3 x U(1) → ZN → nothing. This model fits the low energy data in the charged fermion sector quite well. We discuss the prediction of this model for the proton lifetime in light of recent SuperKamiokande results and present a clear picture of the allowed spectra of supersymmetric particles. Finally, the detailed discussion of the Yukawa coupling unification of the third generation particles is provided. We find a narrow region is consistent with t, b, tau Yukawa unification for mu > 0 (suggested by b → sgamma and the anomalous magnetic moment of the muon) with A0 ˜ -1.9m16, m10 ˜ 1.4m16, m16 ≳ 1200 GeV and mu, M1/2 ˜ 100--500 GeV. Demanding Yukawa unification thus makes definite predictions for Higgs and sparticle masses.

  16. Designing a system for patients controlling providers' access to their electronic health records: organizational and technical challenges.

    Science.gov (United States)

    Leventhal, Jeremy C; Cummins, Jonathan A; Schwartz, Peter H; Martin, Douglas K; Tierney, William M

    2015-01-01

    Electronic health records (EHRs) are proliferating, and financial incentives encourage their use. Applying Fair Information Practice principles to EHRs necessitates balancing patients' rights to control their personal information with providers' data needs to deliver safe, high-quality care. We describe the technical and organizational challenges faced in capturing patients' preferences for patient-controlled EHR access and applying those preferences to an existing EHR. We established an online system for capturing patients' preferences for who could view their EHRs (listing all participating clinic providers individually and categorically-physicians, nurses, other staff) and what data to redact (none, all, or by specific categories of sensitive data or patient age). We then modified existing data-viewing software serving a state-wide health information exchange and a large urban health system and its primary care clinics to allow patients' preferences to guide data displays to providers. Patients could allow or restrict data displays to all clinicians and staff in a demonstration primary care clinic, categories of providers (physicians, nurses, others), or individual providers. They could also restrict access to all EHR data or any or all of five categories of sensitive data (mental and reproductive health, sexually transmitted diseases, HIV/AIDS, and substance abuse) and for specific patient ages. The EHR viewer displayed data via reports, data flowsheets, and coded and free text data displayed by Google-like searches. Unless patients recorded restrictions, by default all requested data were displayed to all providers. Data patients wanted restricted were not displayed, with no indication they were redacted. Technical barriers prevented redacting restricted information in free textnotes. The program allowed providers to hit a "Break the Glass" button to override patients' restrictions, recording the date, time, and next screen viewed. Establishing patient

  17. Selected topics in grand unification

    International Nuclear Information System (INIS)

    Seckel, D.

    1983-01-01

    This dissertation is a collection of four pieces of research dealing with grand unification. The topics are neutron oscillation, CP violation, magnetic monopole abundance and distribution in neutron stars, and a proposal for an inflationary cosmology driven by stress-energy in domain walls

  18. Introduction to grand unification theories

    International Nuclear Information System (INIS)

    Kang, Kyungsik

    1980-01-01

    We introduce the Georgi-Glashow model based on the minimal gauge group SU(5) as a prototype grand unification theory of the electroweak and strong interactions. Simple estimation of sin 2 thetasub(W) in the symmetry limit and the renormalization corrections at the energy scale of Msub(W) are given along wich other successes of the SU(5) model

  19. Electronic Nicotine Delivery System (E-cigarettes marketing, sale and availability - an emerging challenge for tobacco control in India

    Directory of Open Access Journals (Sweden)

    Ravinder Kumar

    2018-03-01

    Full Text Available Background Electronic Nicotine Delivery System (E-cigarettes are being advertised as novel products in all media and platforms across the globe. Despite the fact that these products are still not evaluated for safety and effectiveness by any regulatory body in most countries including India; their advertisements claiming the e-cigarettes to be health friendly is on rampant especially in the internet media.To explore the availability of e-cigarette brands for Indian existing and potential consumers and to understand their distribution network and marketing tactics, the investigator did the internet search. Methods Investigator performed the keyword search on Google in May 2014 and November 2016. Brand websites were examined for specifics about each product (flavor and nicotine strength, ingredients, and their claims about the safety of the products and usefulness in smoking cessation. Distributor's network and kiosk selling these products were also searched for. Results Total 112 brands of different flavor (12 types and different nicotine strengths (9 types of the e-cigarettes were found. In majority brands (95%, most common ingredients were chemical nicotine, propylene glycol, water and flavours. 10% websites claimed that their product are useful as smoking cessation devices. Most brands claimed their product to be healthier and safer (90%, suitable to use in public places (92% and an economical option (70% than conventional cigarettes. Near half of the websites gave their distribution details in the websites. 12 websites offer free shipping services, 27 websites offers the web chat options for marketing the products. Conclusions ENDS (e-cigarette poses another challenge for tobacco control in India. The claims (especially healthier option and useful for cessation of the websites marketing these products are questionable and needs further research. Ongoing advertisements on internet are the gross violations of Indian tobacco control legislation

  20. Electronics

    Science.gov (United States)

    2001-01-01

    International Acer Incorporated, Hsin Chu, Taiwan Aerospace Industrial Development Corporation, Taichung, Taiwan American Institute of Taiwan, Taipei, Taiwan...Singapore and Malaysia .5 - 4 - The largest market for semiconductor products is the high technology consumer electronics industry that consumes up...Singapore, and Malaysia . A new semiconductor facility costs around $3 billion to build and takes about two years to become operational

  1. Preface to a GUT (Grand Unified Theory)

    International Nuclear Information System (INIS)

    Honig, W.

    1982-01-01

    A Grand Unified Theory (GUT) is proposed exhibiting relativistic invariance and based on a physical model for vacuum space consisting of the superposition of oppositely charged continuous fluids. Models for the photon, electron, neutrino, proton, etc., consist of separate unique variations in the relative densities of the fluids and their flow patterns. This GUT is also based on the use of transfinite axiomatic number forms and on a concept of metrical relativity which hopefully reconciles the many logical dichotomies in and between Special Relativity and Quantum Mechanics. These ideas result in a number of experimental proposals and predicted results which appear to be underivable from present paradigms, first among which is a physical model for the hidden variable of Quantum Mechanics. It is on these features that attention should rest. (Auth.)

  2. Saturn's Internal Magnetic Field Revealed by Cassini Grand Finale

    Science.gov (United States)

    Cao, H.; Dougherty, M. K.; Khurana, K. K.; Hunt, G. J.; Provan, G.; Kellock, S.; Burton, M. E.; Burk, T. A.

    2017-12-01

    Saturn's internal magnetic field has been puzzling since the first in-situ measurements during the Pioneer 11 Saturn flyby. Cassini magnetometer measurements prior to the Grand Finale phase established 1) the highly axisymmetric nature of Saturn's internal magnetic field with a dipole tilt smaller than 0.06 degrees, 2) at least an order of magnitude slower secular variation rate compared to that of the current geomagnetic field, and 3) expulsion of magnetic fluxes from the equatorial region towards high latitude. The highly axisymmetric nature of Saturn's intrinsic magnetic field not only challenges dynamo theory but also makes an accurate determination of the interior rotation rate of Saturn extremely difficult. The Cassini spacecraft entered the Grand Finale phase in April 2017, during which time the spacecraft dived through the gap between Saturn's atmosphere and the inner edge of the D-ring 22 times before descending into the deep atmosphere of Saturn. The unprecedented proximity to Saturn (reaching 2500 km above the cloud deck) and the highly inclined nature of the Grand Finale orbits provided an ideal opportunity to decode Saturn's internal magnetic field. The fluxgate magnetometer onboard Cassini made precise vector measurements during the Grand Finale phase. Magnetic signals from the interior of the planet, the magnetospheric ring current, the high-latitude field-aligned current (FAC) modulated by the 10.7 hour planetary period oscillation, and low-latitude FACs were observed during the Grand Finale phase. Here we report the magnetometer measurements during the Cassini Grand Finale phase, new features of Saturn's internal magnetic field revealed by these measurements (e.g., the high degree magnetic moments of Saturn, the level of axisymmetry beyond dipole), and implications for the deep interior of Saturn.

  3. Advances and challenges in electron-molecule scattering physics-A Report of the 14th International Symposium on Electron-Molecule Collisions and Swarms

    Energy Technology Data Exchange (ETDEWEB)

    Khakoo, M A [Department of Physics, California State University, Fullerton, CA 92831 (United States); Lima, M A P [Departamento de Eletronica Quantica, Instituto de Fisica ' Gleb Wataghin' -UNICAMP, Caixa Postal 6165, 13083-970 Campinas (Brazil); Tennyson, J [Department of Physics and Astronomy, University College, Gower Street, London WC1E 6BT (United Kingdom)

    2006-07-15

    A report is presented of the 13th International Symposium on Electron-Molecule Collisions Physics (Instituto de Fisica, Unicamp, Campinas, Brazil, 27-30 July 2005). This workshop covered low-energy electron interactions with atoms, molecules and condensed matter systems. Several important aspects of this symposium were to bring together theory and experimental advances in this field for gaseous targets as well as showcasing the increasing diversity of electron-molecule collision applications in condensed matter and biological applications. A summary session was held wherein were discussed aspects of the future of the field, including the development of new theoretical and experimental capabilities.

  4. Results from KASCADE–Grande

    International Nuclear Information System (INIS)

    Bertaina, M.; Apel, W.D.; Arteaga-Velázquez, J.C.; Bekk, K.; Blümer, J.; Bozdog, H.; Brancus, I.M.; Buchholz, P.; Cantoni, E.; Chiavassa, A.; Cossavella, F.

    2012-01-01

    The KASCADE–Grande experiment, located at Karlsruhe Institute of Technology (Germany) is a multi-component extensive air-shower experiment devoted to the study of cosmic rays and their interactions at primary energies 10 14 –10 18 eV. Main goals of the experiment are the measurement of the all-particle energy spectrum and mass composition in the 10 16 –10 18 eV range by sampling charged (N ch ) and muon (N μ ) components of the air shower. The method to derive the energy spectrum and its uncertainties, as well as the implications of the obtained result, is discussed. An overview of the analyses performed by KASCADE–Grande to derive the mass composition of the measured high-energy comic rays is presented as well.

  5. Results from KASCADE-Grande

    Energy Technology Data Exchange (ETDEWEB)

    Bertaina, M., E-mail: bertaina@to.infn.it [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Apel, W.D. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Arteaga-Velazquez, J.C. [Universidad Michoacana, Instituto de Fisica y Matematicas, Morelia (Mexico); Bekk, K. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Bluemer, J. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Institut fuer Experimentelle Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Bozdog, H. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Buchholz, P. [Fachbereich Physik, Universitaet Siegen (Germany); Cantoni, E. [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Istituto di Fisica dello Spazio Interplanetario, INAF Torino (Italy); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Cossavella, F. [Institut fuer Experimentelle Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); and others

    2012-11-11

    The KASCADE-Grande experiment, located at Karlsruhe Institute of Technology (Germany) is a multi-component extensive air-shower experiment devoted to the study of cosmic rays and their interactions at primary energies 10{sup 14}-10{sup 18} eV. Main goals of the experiment are the measurement of the all-particle energy spectrum and mass composition in the 10{sup 16}-10{sup 18} eV range by sampling charged (N{sub ch}) and muon (N{sub {mu}}) components of the air shower. The method to derive the energy spectrum and its uncertainties, as well as the implications of the obtained result, is discussed. An overview of the analyses performed by KASCADE-Grande to derive the mass composition of the measured high-energy comic rays is presented as well.

  6. Software Engineering Support of the Third Round of Scientific Grand Challenge Investigations: An Earth Modeling System Software Framework Strawman Design that Integrates Cactus and UCLA/UCB Distributed Data Broker

    Science.gov (United States)

    Talbot, Bryan; Zhou, Shu-Jia; Higgins, Glenn

    2002-01-01

    One of the most significant challenges in large-scale climate modeling, as well as in high-performance computing in other scientific fields, is that of effectively integrating many software models from multiple contributors. A software framework facilitates the integration task. both in the development and runtime stages of the simulation. Effective software frameworks reduce the programming burden for the investigators, freeing them to focus more on the science and less on the parallel communication implementation, while maintaining high performance across numerous supercomputer and workstation architectures. This document proposes a strawman framework design for the climate community based on the integration of Cactus, from the relativistic physics community, and UCLA/UCB Distributed Data Broker (DDB) from the climate community. This design is the result of an extensive survey of climate models and frameworks in the climate community as well as frameworks from many other scientific communities. The design addresses fundamental development and runtime needs using Cactus, a framework with interfaces for FORTRAN and C-based languages, and high-performance model communication needs using DDB. This document also specifically explores object-oriented design issues in the context of climate modeling as well as climate modeling issues in terms of object-oriented design.

  7. Cassini's Grand Finale Science Highlights

    Science.gov (United States)

    Spilker, Linda

    2017-10-01

    After 13 years in orbit, the Cassini-Huygens Mission to Saturn ended in a science-rich blaze of glory. Cassini returned its final bits of unique science data on September 15, 2017, as it plunged into Saturn's atmosphere satisfying planetary protection requirements. Cassini's Grand Finale covered a period of roughly five months and ended with the first time exploration of the region between the rings and planet.The final close flyby of Titan in late April 2017 propelled Cassini across Saturn’s main rings and into its Grand Finale orbits; 22 orbits that repeatedly dove between Saturn’s innermost rings and upper atmosphere making Cassini the first spacecraft to explore this region. The last orbit turned the spacecraft into the first Saturn upper atmospheric probe.The Grand Finale orbits provided highest resolution observations of both the rings and Saturn, and in-situ sampling of the ring particle composition, Saturn's atmosphere, plasma, and innermost radiation belts. The gravitational field was measured to unprecedented accuracy, providing information on the interior structure of the planet, winds in the deeper atmosphere, and mass of the rings. The magnetic field provided insight into the physical nature of the magnetic dynamo and structure of the internal magnetic field. The ion and neutral mass spectrometer sampled the upper atmosphere for molecules that escape the atmosphere in addition to molecules originating from the rings. The cosmic dust analyzer directly sampled the composition from different parts of the main rings for the first time. Fields and particles instruments directly measured the plasma environment between the rings and planet.Science highlights and new mysteries gleaned to date from the Grand Finale orbits will be discussed.The research described in this paper was carried out in part at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. Copyright 2017

  8. Grandes números primos

    OpenAIRE

    Bang, Thöger

    2012-01-01

    En las escuelas danesas la teoría de los números se ha ido restringiendo gradualmente hasta no incluir sino la demostración de la descomposición univoca de los números enteros en números primos y la demostración del teorema clásico de EUCLIDES sobre la existencia de un número primo arbitrariamente grande.

  9. Grand unification theory and technicolor

    International Nuclear Information System (INIS)

    Rubakov, V.A.; Shaposhnikov, M.E.

    1983-01-01

    The lecture course can be considered as introduction to the problems concerning grand unification models. The course is incomplete. Such problems as CP-violations in strong interactions and the problem of gravitational interaction inclusion in the scheme of grand unification theory are not touched upon. Models of early unification, in which strong, weak and electromagnetic interactions are compared according to the ''strength'' at energies of about 10 5 -10 6 GeV, are not discussed. Models with horizontal symmetry, considering different generations of quarks and leptons from one viewpoint, are not analyzed. Cosmological applications of supersymmetric unified theories are not considered. Certain problems of standard elementary particle theory, philosophy of the great unification, general properties of the grand unification models and the main principles of the construction of models: the SU(5) model, models on the SO(10) groups, have been considered. The problem of supersymmetric unification hierarchies, supersymmetric generalization of the minimum SU(5) model, supersymmetry violation and the problem of hierarchies, phenomenology of the o.rand unification models, cosmological application and technicolour, are discussed

  10. Ultraviolet and soft X-ray free-electron lasers introduction to physical principles, experimental results, technological challenges

    CERN Document Server

    Schmüser, Peter; Rossbach, Jörg; Fujimori, A; Kühn, J; Müller, T; Steiner, F; Trümper, J; Varma, C; Wölfle, P

    2008-01-01

    In the introduction accelerator-based light sources are considered and a comparison is made between free-electron lasers and conventional quantum lasers. The motion and radiation of relativistic electrons in undulator magnets is discussed. The principle of a low-gain free-electron laser is explained and the pendulum equations are introduced that characterize the electron dynamics in the field of a light wave. The differential equations of the high-gain FEL are derived from the Maxwell equations of electrodynamics. Analytical and numerical solutions of the FEL equations are presented and important FEL parameters are defined, such as gain length, FEL bandwidth and saturation power. A detailed numerical study of the all-important microbunching process is presented. The mechanism of Self Amplified Spontaneous Emission is described theoretically and illustrated with numerous experimental results. Three-dimensional effects such as betatron oscillations and optical diffraction are addressed and their impact on the F...

  11. Grand unification: quo vadis domine

    International Nuclear Information System (INIS)

    Senjanovic, G.

    1985-01-01

    The present theoretical and experimental situation with grand unification is summarized. The issues of proton decay and the Weinberg angle are addressed, going through the predictions of both the standard SU(5) theory and its supersymmetric extension. The SO(10) theory, which provides a minimal one family model, is then studied. The gravitational characteristics of domain walls and strings are then discussed. It is argued that there is a need to go beyond SO(10) in order to incorporate a unified picture of families. This leads to the prediction of mirror fermions, whose physics is analyzed. 31 refs

  12. Graafikatriennaali grand prix Korea kunstnikule

    Index Scriptorium Estoniae

    1998-01-01

    Tallinna XI graafikatriennaali rahvusvaheline žürii andis grand prix korea kunstnikule Chung¡Sang-Gonile, kolm võrdset preemiat - soome kunstnikele Anita Jensenile ja Tapani Mikkonenile ning jaapani kunstnikule Estuko Obatale. Eesti Kunstimuuseumi preemia - Wendy Swallow. Tallinna linna preemia ja Ivar Luki sponsoripreemia - Walter Jule. Sponsoripreemiad : Paletti Eesti AS preemia - Inga Heamägi; Rannila Profiili preemia - Mojca Zlokarnik; UNDP preemia - Andrea Juan. Rotermanni soolalao arhitektuuri- ja kunstikeskuse diplom - Lis Ingram, Heli Päivikki Kurunsaari, Randi Strand, Wendy Swallow

  13. Surface and Interface Physics of Correlated Electron Materials

    Energy Technology Data Exchange (ETDEWEB)

    Millis, Andrew [Columbia Univ., New York, NY (United States)

    2004-09-01

    The {\\it Surface and Interface Physics of Correlated Electron Materials} research program provided conceptual understanding of and theoretical methodologies for understanding the properties of surfaces and interfaces involving materials exhibiting strong electronic correlations. The issues addressed in this research program are important for basic science, because the behavior of correlated electron superlattices is a crucial challenge to and crucial test of our understanding of the grand-challenge problem of correlated electron physics and are important for our nation's energy future because correlated interfaces offer opportunities for the control of phenomena needed for energy and device applications. Results include new physics insights, development of new methods, and new predictions for materials properties.

  14. [Theory of elementary particles studies in weak interaction and grand unification and studies in accelerator design

    International Nuclear Information System (INIS)

    1991-01-01

    This report discusses research in high energy physics on the following topics: rare b decays; flavor changing top decays;neutrino physics; standard model; cp violation; heavy ion collisions; electron-positron interactions; electron-hadron interactions; hadron-hadron interactions; deep inelastic scattering; and grand unified models

  15. Grand Challenges in Space Technology: Distributed Satellite Systems

    National Research Council Canada - National Science Library

    Miller, David

    2001-01-01

    The MITIAFRL Distributed Satellite Systems program examines the motivation, analysis and development of technology associated with the distribution of assets and functionality over a number of cooperating satellites...

  16. Science, technology and the 'grand challenge' of aging

    DEFF Research Database (Denmark)

    Jæger, Birgit; Peine, Alexander; Moors, Ellen

    2015-01-01

    In this paper, we introduce the themes addressed and the approaches used in this special issue. We start by briefly discussing the state of the art in research and policy making related to science, technology and ageing. We argue that an important gap characterizes this state of the art: current...... approaches do not consider material practice and materiality to be an inherent part of later life as constituted in contemporary societies. Science and Technology Studies (STS) provide both the theories and methods to address this gap, and thus deploy a theoretical and empirical understanding of science......, technology and ageing that captures how later life co-evolves with the practices of technology use and design. We briefly discuss how the articles in the collection each contribute to such an understanding across various locations. We conclude that, together, the contributions specify a perspective...

  17. Grand Challenges Learning Analytics and Open Online Onderwijs

    NARCIS (Netherlands)

    Manderveld, Jocelyn; Berg, Alan; Schuwer, Robert; Drachsler, Hendrik

    2018-01-01

    Als onderdeel van het programma voor open en online onderwijs werkt SURF samen met de hogescholen en universiteiten aan kennisontwikkeling op allerlei thema’s. Deze uitgave is een eerste verkenning van de mogelijkheden om learning analytics in te zetten bij open en online onderwijs en de uitdagingen

  18. Accelerating cooperative systems' development through the Grand Cooperative Driving challenge

    NARCIS (Netherlands)

    Vonk Noordegraaf, D.; Malone, K.M.; Katwijk, R. van; Gerrits, A.

    2009-01-01

    Cooperative driving systems comprise an important research area. They are considered a promising solution for reducing traffic congestion, reducing environmental impact and improving traffic safety and driver comfort. The key to these systems is the communication and interaction between vehicles and

  19. Grand Challenges in Physics Education Research: Teacher Preparation

    Science.gov (United States)

    Heron, Paula

    2015-04-01

    The courses, curricula and programs that produce new K-12 teachers have been the subject of research in the physics education community for many years. In terms of recruitment, curricula, and mentoring, programs and pathways vary considerably from institution to institution. Each program addresses many different aspects of teaching including knowledge of the content and familiarity with best teaching practices. At the same time, even within physics (or physical science) there is a broad range of student outcomes that are considered important, including acquisition of factual knowledge, development of skill with disciplinary practices, and positive attitudes toward the discipline and one's own abilities. Given the broad range of both input and outcome variables it is no surprise that there are very few clear answers about the impact of teacher preparation on teachers, students and society. In this talk I will summarize some of the main findings to date, and identify some areas where much more research is needed.

  20. The Grand Challenges of Command and Control Policy

    Science.gov (United States)

    2006-06-01

    Memetic Warfare Memes are ideas that can be modeled and simulated. In a modern journalistic environment, dynamic information feedback from the theater...output type such that both adversarial meme processes and our counter anti- memetic activity could be modeled, simulated, and assessed. I am now...opposing force of the consequence of using biological or chemical weapons on the invading American forces. Do we have the proper memetic dynamics

  1. Security and Privacy Grand Challenges for the Internet of Things

    Energy Technology Data Exchange (ETDEWEB)

    Fink, Glenn A.; Zarzhitsky, Dimitri V.; Carroll, Thomas E.; Farquhar, Ethan D.

    2015-08-20

    Abstract— The growth of the Internet of Things (IoT) is driven by market pressures, and while security is being considered, the relationship between the unintended consequences of billions of such devices connecting to the Internet cannot be described with existing mathematical methods. The possibilities for illicit surveillance through lifestyle analysis, unauthorized access to information, and new attack vectors will continue to increase by 2020, when up-to 50 billion devices may be connected. This paper discusses various kinds of vulnerabilities that can be expected to arise, and presents a research agenda for mitigating the worst of the impacts. We hope to draw research attention to the potential dangers of IoT so that many of these problems can be avoided.

  2. Face recognition's grand challenge: uncontrolled conditions under control

    NARCIS (Netherlands)

    Boom, B.J.

    2010-01-01

    The number of cameras increases rapidly in squares, shopping centers, railway stations and airport halls. There are hundreds of cameras in the city center of Amsterdam. This is still modest compared to the tens of thousands of cameras in London, where citizens are expected to be filmed by more than

  3. Grand Challenge Portfolio: Driving Innovation in Industrial Energy Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-01-04

    Under the Recovery Act, AMO provided cost-shared funding for early-stage, low-cost, "concept definition studies" of 47 promising innovations for next-generation manufacturing, energy-intensive processes, advanced materials, and greenhouse gas emissions reduction. The brochure provides information on each of these projects.

  4. Flexible Environments for Grand-Challenge Simulation in Climate Science

    Science.gov (United States)

    Pierrehumbert, R.; Tobis, M.; Lin, J.; Dieterich, C.; Caballero, R.

    2004-12-01

    Current climate models are monolithic codes, generally in Fortran, aimed at high-performance simulation of the modern climate. Though they adequately serve their designated purpose, they present major barriers to application in other problems. Tailoring them to paleoclimate of planetary simulations, for instance, takes months of work. Theoretical studies, where one may want to remove selected processes or break feedback loops, are similarly hindered. Further, current climate models are of little value in education, since the implementation of textbook concepts and equations in the code is obscured by technical detail. The Climate Systems Center at the University of Chicago seeks to overcome these limitations by bringing modern object-oriented design into the business of climate modeling. Our ultimate goal is to produce an end-to-end modeling environment capable of configuring anything from a simple single-column radiative-convective model to a full 3-D coupled climate model using a uniform, flexible interface. Technically, the modeling environment is implemented as a Python-based software component toolkit: key number-crunching procedures are implemented as discrete, compiled-language components 'glued' together and co-ordinated by Python, combining the high performance of compiled languages and the flexibility and extensibility of Python. We are incrementally working towards this final objective following a series of distinct, complementary lines. We will present an overview of these activities, including PyOM, a Python-based finite-difference ocean model allowing run-time selection of different Arakawa grids and physical parameterizations; CliMT, an atmospheric modeling toolkit providing a library of 'legacy' radiative, convective and dynamical modules which can be knitted into dynamical models, and PyCCSM, a version of NCAR's Community Climate System Model in which the coupler and run-control architecture are re-implemented in Python, augmenting its flexibility and adaptability.

  5. Facing the Grand Challenges through Heuristics and Mindfulness

    Science.gov (United States)

    Powietrzynska, Malgorzata; Tobin, Kenneth; Alexakos, Konstantinos

    2015-01-01

    We address the nature of mindfulness and its salience to education generally and to science education specifically. In a context of the historical embeddedness of mindfulness in Buddhism we discuss research in social neuroscience, presenting evidence for neuronal plasticity of the brain and six emotional styles, which are not biologically…

  6. Engineering central metabolism – a grand challenge for plant biologists

    DEFF Research Database (Denmark)

    Sweetlove, Lee J.; Nielsen, Jens; Fernie, Alisdair R.

    2017-01-01

    The goal of increasing crop productivity and nutrient-use efficiency is being addressed by a number of ambitious research projects seeking to re-engineer photosynthetic biochemistry. Many of these projects will require the engineering of substantial changes in fluxes of central metabolism. However......, as has been amply demonstrated in simpler systems such as microbes, central metabolism is extremely difficult to rationally engineer. This is because of multiple layers of regulation that operate to maintain metabolic steady state and because of the highly connected nature of central metabolism....... In this review we discuss new approaches for metabolic engineering that have the potential to address these problems and dramatically improve the success with which we can rationally engineer central metabolism in plants. In particular, we advocate the adoption of an iterative ‘design-build-test-learn’ cycle...

  7. Understanding rare disease pathogenesis: a grand challenge for model organisms.

    Science.gov (United States)

    Hieter, Philip; Boycott, Kym M

    2014-10-01

    In this commentary, Philip Hieter and Kym Boycott discuss the importance of model organisms for understanding pathogenesis of rare human genetic diseases, and highlight the work of Brooks et al., "Dysfunction of 60S ribosomal protein L10 (RPL10) disrupts neurodevelopment and causes X-linked microcephaly in humans," published in this issue of GENETICS. Copyright © 2014 by the Genetics Society of America.

  8. The tip of the iceberg : challenges of accessing hospital electronic health record data for biological data mining

    NARCIS (Netherlands)

    Denaxas, Spiros C; Asselbergs, Folkert W; Moore, Jason H

    2016-01-01

    Modern cohort studies include self-reported measures on disease, behavior and lifestyle, sensor-based observations from mobile phones and wearables, and rich -omics data. Follow-up is often achieved through electronic health record (EHR) linkages across primary and secondary healthcare providers.

  9. Design challenges and gaps in standards in developing an interoperable zero footprint DI thin client for use in image-enabled electronic health record solutions

    Science.gov (United States)

    Agrawal, Arun; Koff, David; Bak, Peter; Bender, Duane; Castelli, Jane

    2015-03-01

    The deployment of regional and national Electronic Health Record solutions has been a focus of many countries throughout the past decade. A major challenge for these deployments has been support for ubiquitous image viewing. More specifically, these deployments require an imaging solution that can work over the Internet, leverage any point of service device: desktop, tablet, phone; and access imaging data from any source seamlessly. Whereas standards exist to enable ubiquitous image viewing, few if any solutions exist that leverage these standards and meet the challenge. Rather, most of the currently available web based DI viewing solutions are either proprietary solutions or require special plugins. We developed a true zero foot print browser based DI viewing solution based on the Web Access DICOM Objects (WADO) and Cross-enterprise Document Sharing for Imaging (XDS-I.b) standards to a) demonstrate that a truly ubiquitous image viewer can be deployed; b) identify the gaps in the current standards and the design challenges for developing such a solution. The objective was to develop a viewer, which works on all modern browsers on both desktop and mobile devices. The implementation allows basic viewing functionalities of scroll, zoom, pan and window leveling (limited). The major gaps identified in the current DICOM WADO standards are a lack of ability to allow any kind of 3D reconstruction or MPR views. Other design challenges explored include considerations related to optimization of the solution for response time and low memory foot print.

  10. The role of electronic assessment of adherence in the education and counseling of children taking growth hormone: progress and challenges.

    Science.gov (United States)

    Haverkamp, Fritz; Norgren, Svante; Horne, Rob; Gasteyger, Christoph

    There are numerous issues surrounding adherence in children taking recombinant human growth hormone (rh-GH). New technologies capable of accurately recording/monitoring may highlight some of these issues, and have value in optimizing adherence levels through education and counseling. The intention of this review is to guide healthcare professionals (HCPs). PubMed, Google Scholar and citations in published papers were used to substantiate the views expressed by the authors. Both perceptional and practical factors influence the adherence levels of children taking rh-GH. Understanding such factors may help to identify the characteristics of ideal rh-GH devices and their potential impact on adherence. New technologies, such as electronic monitors, may facilitate patient-provider discussions on adherence, and help identify barriers that are amenable to change. Monitoring adherence may also help differentiate nonadherence from biological low response to rh-GH therapy. However, the medical, psychological, social and ethical aspects of electronic assessment require further investigation.

  11. Proton hexality in local grand unification

    Energy Technology Data Exchange (ETDEWEB)

    Foerste, Stefan; Nilles, Hans Peter [Bonn Univ. (Germany). Bethe Center for Theoretical Physics and Physikalisches Institut; Ramos-Sanchez, Saul [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Vaudrevange, Patrick K.S. [Muenchen Univ. (Germany). Arnold Sommerfeld Center for Theoretical Physics

    2010-07-15

    Proton hexality is a discrete symmetry that avoids the problem of too fast proton decay in the supersymmetric extension of the standard model. Unfortunately it is inconsistent with conventional grand unification. We show that proton hexality can be incorporated in the scheme of ''Local Grand Unification'' discussed in the framework of model building in (heterotic) string theory. (orig.)

  12. Proton decay: Numerical simulations confront grand unification

    International Nuclear Information System (INIS)

    Brower, R.C.; Maturana, G.; Giles, R.C.; Moriarty, K.J.M.; Samuel, S.

    1985-01-01

    The Grand Unified Theories of the electromagnetic, weak and strong interactions constitute a far reaching attempt to synthesize our knowledge of theoretical particle physics into a consistent and compelling whole. Unfortunately, many quantitative predictions of such unified theories are sensitive to the analytically intractible effects of the strong subnuclear theory (Quantum Chromodynamics or QCD). The consequence is that even ambitious experimental programs exploring weak and super-weak interaction effects often fail to give definitive theoretical tests. This paper describes large-scale calculations on a supercomputer which can help to overcome this gap between theoretical predictions and experimental results. Our focus here is on proton decay, though the methods described are useful for many weak processes. The basic algorithms for the numerical simulation of QCD are well known. We will discuss the advantages and challenges of applying these methods to weak transitions. The algorithms require a very large data base with regular data flow and are natural candidates for vectorization. Also, 32-bit floating point arithmetic is adequate. Thus they are most naturally approached using a supercomputer alone or in combination with a dedicated special purpose processor. (orig.)

  13. Excited electronic states of MnO{sub 4}{sup −}: Challenges for wavefunction and density functional response theories

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Nuno M.S.; McKinlay, Russell G.; Paterson, Martin J., E-mail: m.j.paterson@hw.ac.uk

    2015-01-13

    Highlights: • Linear response coupled cluster hierarchy CCS, CC2, CCSD, CC3 applied to lowest excited states of MnO{sub 4}{sup −}. • Unphysical results obtained for approximate CCn methods. • Failure traced to very large singles amplitudes. • HF and RASSCF calculations on ground state show strong correlations give very poor HF single particle picture. • TD-CAM-B3LYP describes LMCT states with reasonable accuracy. - Abstract: The lowest excited electronic states of the permanganate ion MnO{sub 4}{sup −} are calculated using a hierarchy of coupled cluster response approaches, as well as time-dependent density functional theory. It is shown that while full linear response coupled cluster with singles and doubles (or higher) performs well, that permanganate represents a stern test for approximate coupled cluster response models, and that problems can be traced to very large orbital relaxation effects. TD-DFT is reasonably robust although errors around 0.6 eV are still observed. In order to further investigate the strong correlations prevalent in the electronic ground state large-scale RASSCF calculations were also performed. Again very large orbital relaxation in the correlated wavefunction is observed. Although the system can qualitatively be described by a single configuration, multi-reference diagnostic values show that care must be taken in this and similar metal complexes.

  14. La Grande: volver a empezar

    Directory of Open Access Journals (Sweden)

    Julio Premat

    2011-07-01

    Full Text Available Este texto, borrador de un trabajo más amplio, pretende despejar algunas pistas de lectura de La grande, en tanto que paradójico final de la producción de Saer. Digo “paradójico” porque puede tomársela como una novela de comienzo o de origen : de un volver a empezar, en todos los sentidos del término. En esa perspectiva podrían estudiarse algunos núcleos temáticos (como el retorno o el recuerdo de cara a la construcción del texto, a la relación planteada con la tradición y a la singular historia de su escritura (y al material genético que rodea y completa esta novela a la vez inacabada y póstuma. En esta intervención, la idea es la de comentar tres textos, escenas o frases del texto, y a partir de allí esbozar pistas para un estudio que está en ciernes.Première ébauche d’un travail de plus d’ampleur, ce texte vise à éclairer quelques pistes de lecture de La grande, en tant que fin paradoxale de la production de Saer. Je dis « paradoxale » parce que l’on peut considérer cette œuvre comme un roman des commencements ou des origines : comme un retour aux débuts, dans tous les sens du terme. Dans cette perspective, plusieurs nœuds thématiques (comme le retour ou le souvenir pourraient être étudiés en relation à la construction du texte, à la relation qui s’établit avec la tradition et à la singulière histoire de son écriture (et au matériau génétique qui entoure et complète ce roman, à la fois inachevé et posthume. Il sera question ici de commenter trois textes, scènes ou phrases du texte, et d’ébaucher à partir de là quelques pistes pour une étude à l’état naissant.The objective of this text, a draft for a broader work, is to outline some reading clues for La grande, inasmuch as it constitutes a paradoxical ending of Saer’s production. I say “paradoxical” because we can consider this work a novel of beginnings or of origins: a return to the beginning, in every meaning of the

  15. Human- Versus System-Level Factors and Their Effect on Electronic Work List Variation: Challenging Radiology's Fundamental Attribution Error.

    Science.gov (United States)

    Davenport, Matthew S; Khalatbari, Shokoufeh; Platt, Joel F

    2015-09-01

    The aim of this study was to analyze sources of variation influencing the unread volume on an electronic abdominopelvic CT work list and to compare those results with blinded radiologist perception. The requirement for institutional review board approval was waived for this HIPAA-compliant quality improvement effort. Data pertaining to an electronic abdominopelvic CT work list were analyzed retrospectively from July 1, 2013, to June 30, 2014, and modeled with respect to the unread case total at 6 pm (Monday through Friday, excluding holidays). Eighteen system-level factors outside individual control (eg, number of workers, workload) and 7 human-level factors within individual control (eg, individual productivity) were studied. Attending radiologist perception was assessed with a blinded anonymous survey (n = 12 of 15 surveys completed). The mean daily unread total was 24 (range, 3-72). The upper control limit (48 CT studies [3 SDs above the mean]) was exceeded 10 times. Multivariate analysis revealed that the rate of unread CT studies was affected principally by system-level factors, including the number of experienced trainees on service (postgraduate year 5 residents [odds ratio, 0.83; 95% confidence interval, 0.74-0.92; P = .0008] and fellows [odds ratio, 0.84; 95% confidence interval, 0.74-0.95; P = .005]) and the daily workload (P = .02 to P level factors best predict the variation in unread CT examinations, but blinded faculty radiologists believe that it relates most strongly to variable individual effort. Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  16. A study of user requests regarding the fully electronic health record system at Seoul National University Bundang Hospital: challenges for future electronic health record systems.

    Science.gov (United States)

    Yoo, Sooyoung; Kim, Seok; Lee, Seungja; Lee, Kee-Hyuck; Baek, Rong-Min; Hwang, Hee

    2013-05-01

    Although the adoption rates for Electronic Health Records (EHRs) are growing, significant opportunities for further advances in EHR system design remain. The goal of this study was to identify issues that should be considered in the design process for the successful development of future systems by analyzing end users' service requests gathered during a recent three-year period after a comprehensive EHR system was implemented at Seoul National University's Bundang Hospital in South Korea. Data on 11,400 service requests from end users of the EHR system made from 2008 through 2010 were used in this study. The requests were categorized as program modification/development, data request, insurance-fee identification/generation, patient-record merging, or other. The authors further subcategorized the requests for program modification/development into the following nine areas of concern: (1) indicators and statistics, (2) patient safety and quality of care, (3) special task-oriented functionalities, (4) ease of use and user interface, (5) system speed, (6) interoperability and integration, (7) privacy and security, (8) customer service, and (9) miscellaneous. The system users were divided into four groups--direct care, care support, administrative/insurance, and general management--to identify each group's needs and concerns. The service requests for program modification/development, data request, insurance-fee identification/generation, patient-record merging, and other issues constituted approximately 49.2%, 33.9%, 11.4%, 4.0%, and 1.5% of the total data set, respectively. The number of data-request service requests grew over the three years studied. Different groups of users were found to have different concerns according to their activities and tasks. Within the program-modification/development category, end users were most frequently concerned with ease of use and user interface (38.1% of the total) and special task-oriented functionalities (29.3% of the total) in

  17. GrandBase: generating actionable knowledge from Big Data

    Directory of Open Access Journals (Sweden)

    Xiu Susie Fang

    2017-08-01

    Full Text Available Purpose – This paper aims to propose a system for generating actionable knowledge from Big Data and use this system to construct a comprehensive knowledge base (KB, called GrandBase. Design/methodology/approach – In particular, this study extracts new predicates from four types of data sources, namely, Web texts, Document Object Model (DOM trees, existing KBs and query stream to augment the ontology of the existing KB (i.e. Freebase. In addition, a graph-based approach to conduct better truth discovery for multi-valued predicates is also proposed. Findings – Empirical studies demonstrate the effectiveness of the approaches presented in this study and the potential of GrandBase. The future research directions regarding GrandBase construction and extension has also been discussed. Originality/value – To revolutionize our modern society by using the wisdom of Big Data, considerable KBs have been constructed to feed the massive knowledge-driven applications with Resource Description Framework triples. The important challenges for KB construction include extracting information from large-scale, possibly conflicting and different-structured data sources (i.e. the knowledge extraction problem and reconciling the conflicts that reside in the sources (i.e. the truth discovery problem. Tremendous research efforts have been contributed on both problems. However, the existing KBs are far from being comprehensive and accurate: first, existing knowledge extraction systems retrieve data from limited types of Web sources; second, existing truth discovery approaches commonly assume each predicate has only one true value. In this paper, the focus is on the problem of generating actionable knowledge from Big Data. A system is proposed, which consists of two phases, namely, knowledge extraction and truth discovery, to construct a broader KB, called GrandBase.

  18. A Grande Reportagem no contexto informativo SIC

    OpenAIRE

    Colaço, Vanessa Alexandra Francisco

    2014-01-01

    Os telespectadores querem ver grandes reportagens? Como evoluíram as audiências da Grande Reportagem SIC? É este o produto premium da estação? Terá este formato um investimento e continuidade garantidas? Estas são algumas das questões formuladas e às quais se procurou dar resposta neste Relatório de Estágio. Neste trabalho traça-se o perfil do programa Grande Reportagem SIC, clarificando a linha editorial que lhe serviu de base, procurando perceber as suas dinâmicas e passando em revista mome...

  19. Supersymmetry and supergravity: Phenomenology and grand unification

    International Nuclear Information System (INIS)

    Arnowitt, R.; Nath, P.

    1993-01-01

    A survey is given of supersymmetry and supergravity and their phenomenology. Some of the topics discussed are the basic ideas of global supersymmetry, the minimal supersymmetric Standard Model (MSSM) and its phenomenology, the basic ideas of local supersymmetry (supergravity), grand unification, supersymmetry breaking in supergravity grand unified models, radiative breaking of SU(2) x U(1), proton decay, cosmological constraints, and predictions of supergravity grand unified models. While the number of detailed derivations are necessarily limited, a sufficient number of results are given so that a reader can get a working knowledge of this field

  20. Las cinco grandes dimensiones de la personalidad

    Directory of Open Access Journals (Sweden)

    Jan ter Laak

    1996-12-01

    Full Text Available Este artículo revisa las distintas posiciones teóricas sobre las cinco grandes dimensiones de la personalidad, mostrando las semejanzas y diferencias entre las posturas teóricas. Esta contribución presenta lo siguiente: (a la génesis del contenido y la estructura de las cinco dimensiones; (b la fortaleza de las cinco dimensiones; (e la relación de las cinco grandes dimensiones con otros constructos de personalidad; (d discute el valor predictivo de las puntuaciones del perfil de las cinco dimensiones para criterios pertinentes; (e analiza el estatus teórico de las cinco dimensiones; (f discute críticas históricas sobre las cinco grandes dimensiones y se formulan respuestas a estas críticas; (g hace conjeturas para el futuro de las cinco grandes dimensiones; y (h concluye con algunas conclusiones y comentarios.

  1. Sustainable Management of Electronics

    Science.gov (United States)

    To provide information on EPAs strategy for electronics stewardship, certified electronics recyclers and the Challenge; as well as where to donate unwanted electronics, how to calculate benefits, and what's going on with electronics mgmt in their states.

  2. Grand unification and gravity - selected topics

    International Nuclear Information System (INIS)

    Zee, A.

    1981-09-01

    The material given here was presented in lectures delivered at the 4th Kyoto Summer Institute on Grand Unification and Related Topics. It consists of six sections. The sections are: the family problem, fermion mass hierarchy, maximal local symmetry, operator analysis of new physics, dynamically generated gravity, and Kaluza theory and grand unification. The last section contains a (hopefully) pedagogical introduction to Kaluza theory. For pedagogical completeness, several appendices reviewing some elementary notions of differential geometry have been added

  3. General structure of the GRAND program for analysis of the data from a neutrino detector

    International Nuclear Information System (INIS)

    Zhigunov, V.P.; Kulikov, V.A.; Mukhin, S.A.; Naumov, V.L.; Platonov, V.G.; Spiridonov, A.A.

    1985-01-01

    The general structure of the GRAND (Global Result Analysis for Neutrino Detector) program used for geometrical and kinematic reconstruction of events recorded by a neutrino detector is considered. The detector consists of a calorimeter-target, a shower electron and γ detector and a magnetic spectrometer. While developing the GRAND program the multivariance (different types of the computers used), availability of various algorithms for solving the same problem, solution of separate particlular problems within the frames of one program are taken into account. The KERNLIB library and the HBOOK, ZBOOK, EPIO and FFREAD subroutine packages are used while creating the program as basic libraries

  4. The Role Of The «Grand Schools» And The «Grand Corps» As Recruitment Channels For French Ministers

    Directory of Open Access Journals (Sweden)

    I. A. Zarankin

    2017-01-01

    Full Text Available The recruitment of ministers among high-ranking officials, who studied in the «grand schools» and worked in the «grand corps», is one of the typical traits of the Fifth republic. This is a consequence of the traditional interpenetration of French administrative and political elites. However, there is no common view on the actual role of these institutions in the ministers’ recruitment. So, the objective of this paper is to clarify this issue. For this purpose we analyze career trajectories of French ministers from 1981 till 2016. The data on each government include shares of ministers, who passed through the «grand schools» and the «grand corps». The article shows that nowadays the number of ministers with such an experience has decreased. Most government members are professional politicians, who have significant electoral experience and occupy high-ranking party positions. Today there are political parties, not the «grand schools» and the «grand corps», that are the main channels of the ministers’ recruitment. The professionalization of politics and reinforcement of the role of parties in the French political system are the most crucial factors of this tendency. The transformation of gaullists into liberals and conduction of the liberal economic policy, instead of the dirigist one, also contributed to replacement of officials by representatives of the private sector. Despite the fact that political parties serve as a main channel of the ministers’ recruitment, they face internal problems. The future role of political parties in the recruitment will depend on their ability to deal with these challenges.

  5. Effective Higgs theories in supersymmetric grand unification

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Sibo [Chongqing University, Department of Physics, Chongqing (China)

    2017-09-15

    The effective Higgs theories at the TeV scale in supersymmetric SU(5) grand unification models are systematically derived. Restricted to extensions on 5{sub H} containing the Higgs sector we show that only two types of real (vector-like) models and one type of chiral model are found to be consistent with perturbative grand unification. While the chiral model has been excluded by the LHC data, the fate of perturbative unification will be uniquely determined by the two classes of vector-like models. (orig.)

  6. Grand Tour: immaginario, territorio e culture digitali

    Directory of Open Access Journals (Sweden)

    Emiliano Ilardi

    2016-12-01

    Full Text Available Il Grand Tour può essere recuperato come asset narrativo utile per un intervento strategico di re-branding del viaggio in Italia? Il contributo analizza il contesto e le condizioni per una progettazione di questo livello nell’ambiente culturale dell’epoca digitale. Considerando gli archetipi moderni della mediazione dei luoghi come una grande riserva di senso, da riattivare sia nelle pratiche basate sui format seriali e transmediali che valorizzano i territori nella produzione creativa, sia nella costruzione di infrastrutture digitali e  transluoghi per la valorizzazione degli attrattori culturali.

  7. A Unified Grand Tour of Theoretical Physics

    CERN Document Server

    Lawrie, Ian D

    2002-01-01

    A unified account of the principles of theoretical physics, A Unified Grand Tour of Theoretical Physics, Second Edition stresses the inter-relationships between areas that are usually treated as independent. The profound unifying influence of geometrical ideas, the powerful formal similarities between statistical mechanics and quantum field theory, and the ubiquitous role of symmetries in determining the essential structure of physical theories are emphasized throughout.This second edition conducts a grand tour of the fundamental theories that shape our modern understanding of the physical wor

  8. UMTRA project water sampling and analysis plan, Grand Junction, Colorado

    International Nuclear Information System (INIS)

    1994-07-01

    Surface remedial action will be completed at the Grand Junction processing site during the summer of 1994. Results of 1993 water sampling indicate that ground water flow conditions and ground water quality at the processing site have remained relatively constant with time. Uranium concentrations in ground water continue to exceed the maximum concentration limits, providing the best indication of the extent of contaminated ground water. Evaluation of surface water quality of the Colorado River indicate no impact from uranium processing activities. No compliance monitoring at the Cheney disposal site has been proposed because ground water in the Dakota Sandstone (uppermost aquifer) is classified as limited-use (Class 111) and because the disposal cell is hydrogeologically isolated from the uppermost aquifer. The following water sampling and water level monitoring activities are planned for calendar year 1994: (i) Semiannual (early summer and late fall) sampling of six existing monitor wells at the former Grand Junction processing site. Analytical results from this sampling will be used to continue characterizing hydrogeochemical trends in background ground water quality and in the contaminated ground water area resulting from source term (tailings) removal. (ii) Water level monitoring of approximately three proposed monitor wells projected to be installed in the alluvium at the processing site in September 1994. Data loggers will be installed in these wells, and water levels will be electronically monitored six times a day. These long-term, continuous ground water level data will be collected to better understand the relationship between surface and ground water at the site. Water level and water quality data eventually will be used in future ground water modeling to establish boundary conditions in the vicinity of the Grand Junction processing site. Modeling results will be used to help demonstrate and document the potential remedial alternative of natural flushing

  9. Test of hadronic interaction models with the KASCADE-Grande muon data

    Directory of Open Access Journals (Sweden)

    Schieler H.

    2013-06-01

    Full Text Available KASCADE-Grande is an air-shower observatory devoted for the detection of cosmic rays with energies in the interval of 1014 – 1018 eV, where the Grande array is responsible for the higher energy range. The experiment comprises different detection systems which allow precise measurements of the charged, electron and muon numbers of extensive air-showers (EAS. These data is employed not only to reconstruct the properties of the primary cosmic-ray particle but also to test hadronic interaction models at high energies. In this contribution, predictions of the muon content of EAS from QGSJET II-2, SIBYLL 2.1 and EPOS 1.99 are confronted with the experimental measurements performed with the KASCADE-Grande experiment in order to test the validity of these hadronic models commonly used in EAS simulations.

  10. Getting real with the upcoming challenge of electronic nicotine delivery systems: The way forward for the South-East Asia region.

    Science.gov (United States)

    Kaur, Jagdish; Rinkoo, Arvind Vashishta

    2017-09-01

    Electronic nicotine delivery systems (ENDS) are being marketed to tobacco smokers for use in places where smoking is not allowed or as aids similar to pharmaceutical nicotine products to help cigarette smokers quit tobacco use. These are often flavored to make them more attractive for youth - ENDS use may lead young nonsmokers to take up tobacco products. Neither safety nor efficacy as a cessation aid of ENDS has been scientifically demonstrated. The adverse health effects of secondhand aerosol cannot be ruled out. Weak regulation of these products might contribute to the expansion of the ENDS market - in which tobacco companies have a substantial stake - potentially renormalizing smoking habits and negating years of intense tobacco control campaigning. The current situation calls for galvanizing policy makers to gear up to this challenge in the Southeast Asia Region (SEAR) where the high burden of tobacco use is compounded by large proportion of young vulnerable population and limited established tobacco cessation facilities. Banning ENDS in the SEAR seems to be the most plausible approach at present. In the SEAR, Timor-Leste, Democratic People's Republic of Korea, and Thailand have taken the lead in banning these products. The other countries of the SEAR should follow suit. The SEAR countries may, however, choose to revise their strategy if unbiased scientific evidence emerges about efficacy of ENDS as a tobacco cessation aid. ENDS industry must show true motivation and willingness to develop and test ENDS as effective pharmaceutical tools in the regional context before asking for market authorization.

  11. Grand Unification as a Bridge Between String Theory and Phenomenology

    Energy Technology Data Exchange (ETDEWEB)

    Pati, Jogesh C.

    2006-06-09

    In the first part of the talk, I explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity--be it string/M theory or a reincarnation--this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2){sub L} x SU(2){sub R} x SU(4){sup c} or SO(10) symmetry in 4D in explaining (1) observed neutrino oscillations, (2) baryogenesis via leptogenesis, and (3) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in {mu} {yields} e{gamma}, {tau} {yields} {mu}{gamma}, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism.

  12. Grand Unification as a Bridge Between String Theory and Phenomenology

    Science.gov (United States)

    Pati, Jogesh C.

    In the first part of this paper, we explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity — be it string/M-theory or a reincarnation — this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2)L × SU(2)R × SU(4)c or SO(10) symmetry in 4D in explaining (i) observed neutrino oscillations, (ii) baryogenesis via leptogenesis, and (iii) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in μ → eγ, τ → μγ, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M-theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism.

  13. Grand Unification as a Bridge Between String Theory and Phenomenology

    International Nuclear Information System (INIS)

    Pati, J

    2006-01-01

    In the first part of the talk, I explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity--be it string/M theory or a reincarnation--this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2) L x SU(2) R x SU(4) c or SO(10) symmetry in 4D in explaining (1) observed neutrino oscillations, (2) baryogenesis via leptogenesis, and (3) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in μ → eγ, τ → μγ, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism

  14. Hilbert's Grand Hotel with a series twist

    Science.gov (United States)

    Wijeratne, Chanakya; Mamolo, Ami; Zazkis, Rina

    2014-08-01

    This paper presents a new twist on a familiar paradox, linking seemingly disparate ideas under one roof. Hilbert's Grand Hotel, a paradox which addresses infinite set comparisons is adapted and extended to incorporate ideas from calculus - namely infinite series. We present and resolve several variations, and invite the reader to explore his or her own variations.

  15. "Teine" võitis Prantsusmaal Grand Prix'

    Index Scriptorium Estoniae

    2006-01-01

    Prantsusmaal Essonne'is toimuval 8. Euroopa filmifestivalil Cinessonne sai üliõpilaste žürii grand prix rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre. Ka teistest festivalidest, kus film osalenud

  16. The Virtual Grand Tour as Educational Paradigm

    DEFF Research Database (Denmark)

    Hansen, Per Skafte; Mouritsen, Lars

    2001-01-01

    The Virtual Grand Tour as defined here bears some resemblance to its 18th century ancestor: a wide range of individual topics are treated as a whole; a tutor, whether real or simulated, present or remote, is provided; a set of problem solving tools forms an integrated part of the "traveller...

  17. Grand Prix Eurovision: Eine Fankultur im Medienzeitalter

    Directory of Open Access Journals (Sweden)

    Heinz Moser

    2017-06-01

    Full Text Available Der Grand Prix Eurovision ist seit Jahrzehnten eine der bekanntesten Unterhaltungssendungen im europäischen Raum. Dennoch erregte es Verwunderung, wenn der Schreibende Bekannten darüber berichtete, daß dies ein Forschungsgegenstand sei. Wurde von Interviews mit Grand Prix-Fans erzählt, so fielen schnell Aussagen wie: „Wie kann man sich nur für so etwas Abseitiges und Triviales wie den Grand Prix interessieren“. Dennoch bin ich der Meinung, daß Fankulturen für die entstehende Mediengesellschaft ein nicht unwichtiges Forschungsthema darstellen. Zwar geht es nicht um eine medienpädagogische Fragestellung im engeren Sinne; die Fans des Grand Prix Eurovision sind dem Jugendalter längst entwachsen. Dennoch handelt es sich bei Fangemeinschaften um Phänomene, die im Rahmen von Jugend- und Kinderkulturen von besonderer Relevanz sind. So meint Winter (1997, daß jugendliche Fanwelten eine bedeutende Rolle als Kristallisationspunkte kultureller Differenzierung spielen: ,Die Zugehörigkeit zu einer Fan weit ist Teil der jugendlichen Lebensbewältigung in der Postmoderne, denn in der Gemeinschaft der Fans können Jugendliche emotionale Allianzen eingehen, außeralltäglichen Beschäftigungen nachgehen, expressive Identitätsmuster gemeinschaftlich realisieren und sich mit ihrer Lebenssituation als Heranwachsende auseinandersetzen“ (Winter 1997, S. 51f..

  18. Grand Canyon Monitoring and Research Center

    Science.gov (United States)

    Hamill, John F.

    2009-01-01

    The Grand Canyon of the Colorado River, one of the world's most spectacular gorges, is a premier U.S. National Park and a World Heritage Site. The canyon supports a diverse array of distinctive plants and animals and contains cultural resources significant to the region's Native Americans. About 15 miles upstream of Grand Canyon National Park sits Glen Canyon Dam, completed in 1963, which created Lake Powell. The dam provides hydroelectric power for 200 wholesale customers in six western States, but it has also altered the Colorado River's flow, temperature, and sediment-carrying capacity. Over time this has resulted in beach erosion, invasion and expansion of nonnative species, and losses of native fish. Public concern about the effects of Glen Canyon Dam operations prompted the passage of the Grand Canyon Protection Act of 1992, which directs the Secretary of the Interior to operate the dam 'to protect, mitigate adverse impacts to, and improve values for which Grand Canyon National Park and Glen Canyon National Recreation Area were established...' This legislation also required the creation of a long-term monitoring and research program to provide information that could inform decisions related to dam operations and protection of downstream resources.

  19. Comprehensive District Reform: Philadelphia's Grand Experiment.

    Science.gov (United States)

    Useem, Elizabeth; Balfanz, Robert

    2002-01-01

    This report describes "Philadelphia's Grand Experiment" in comprehensive school district reform, from its conception through its initial months of implementation. In 2001, as part of the remedy for low student performance, the governor ordered the state to take over governance of the Philadelphia School District, with a substantial…

  20. Rio Branco, grand strategy and naval power

    Directory of Open Access Journals (Sweden)

    João Paulo Alsina Jr.

    2014-12-01

    Full Text Available This article addresses Baron of Rio Branco's grand strategy and the role played by the naval reorganization program (1904-1910 in this context. The ensuing case study determined the domestic and international constraints that affected the program, as well as the worldview of the patron of Brazilian diplomacy regarding military power's instrumentality to foreign policy.

  1. Reisipakkumine - Grand Tour Itaalias / Mai Levin

    Index Scriptorium Estoniae

    Levin, Mai, 1942-

    2009-01-01

    Tiina Abeli koostatud ja Urmas Viigi kujundatud näitus "Grand Tour. Eesti kunstnikud Itaalias" Kumu Kunstimuuseumis 05. aprillini. Loetletud eksponeeritud tööde autoreid. Näitus annab ülevaate, kes siinsetest kunstnikest 19. sajandi algusest kuni 1930ndate aastateni Itaalias käisid ja kuidas see nende loomingut mõjutas

  2. Middle Rio Grande Basin Research Report 2008

    Science.gov (United States)

    Deborah M. Finch; Catherine Dold

    2008-01-01

    An ecosystem is rarely static. A natural system composed of plants, animals, and microorganisms interacting with an area's physical factors, an ecosystem is always fluctuating and evolving. But sometimes, often at the hands of humans, ecosystems change too much. Such is the case with many of the ecosystems of the Middle Rio Grande Basin of New Mexico.

  3. Panel - Rio Grande restoration: Future directions

    Science.gov (United States)

    Deborah M. Finch; Pete V. Domenici; Jeffrey. C. Whitney; Steve Harris; Brian Shields; Clifford S. Crawford

    1996-01-01

    The purpose of this panel was to discuss historical and current changes to the Rio Grande system, focusing on the middle Basin, and to present and review different individual, organizational, and political perspectives on the future of the system. Invitations were made to panelists based on their past and current interests and activities pertaining to restoration of...

  4. Electronic and Ionic Conductors from Ordered Microporous Materials

    Energy Technology Data Exchange (ETDEWEB)

    Dincă, Mircea [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2017-10-30

    The proposed work aimed to establish metal-organic frameworks (MOFs) as new classes of high-surface area microporous electronic and ionic conductors. MOFs are crystalline materials with pore sizes ranging from 0.2 to ~ 2 nm (or larger for the latter) defined by inorganic or organic building blocks connected by rigid organic linkers. Myriad applications have been found or proposed for these materials, yet those that require electron transport or conductivity in combination with permanent porosity still lag behind because the vast majority of known frameworks are electrical insulators. Prior to our proposal and subsequent work, there were virtually no studies exploring the possibility of electronic delocalization in these materials. Therefore, our primary goal was to understand and control, at a fundamental level, the electron and ion transport properties of this class of materials, with no specific application proposed, although myriad applications could be envisioned for high surface area conductors. Our goals directly addressed one of the DOE-identified Grand Challenges for Basic Energy Sciences: designing perfect atom- and energy-efficient syntheses of revolutionary new forms of matter with tailored properties. Indeed, the proposed work is entirely synthetic in nature; owing to the molecular nature of the building blocks in MOFs, there is the possibility of unprecedented control over the structure and properties of solid crystalline matter. The goals also tangentially addressed the Grand Challenge of controlling materials processes at the level of electrons: the scope of our program is to create new materials where charges (electrons and/or ions) move according to predefined pathways.

  5. GRANDES PROJETOS NA AMAZÔNIA: MUDANÇAS E PERSPECTIVAS NA PRODUÇÃO DO ESPAÇO URBANO EM IRANDUBA – AM (Great projects in the Amazon: challenges and prospects in the production of urban space in Iranduba – AM)

    OpenAIRE

    SOUSA, Isaque dos Santos

    2011-01-01

    Neste artigo discute-se algumas das recentes transformações observadas na cidade de Iranduba-AM influenciada por dois grandes projetos de infraestrutura: o gasoduto Coari-Manaus e a ponte sobre o rio Negro. As análises postas são feitas com base na observação direta em campo, na coleta de dados em bancos oficiais como o do Sistema Único de Saúde – Datasus e o Instituto Brasileiro de Geografia e Estatística – IBGE. Dentre as principais mudanças na cidade em estudo, destacam-se o crescimento da...

  6. The Grand Ethiopian Renaissance Dam: Source of cooperation or contention?

    Science.gov (United States)

    Teferi Taye, Meron; Tadesse, Tsegaye; Senay, Gabriel; Block, Paul

    2016-01-01

    This paper discusses the challenges and benefits of the Grand Ethiopian Renaissance Dam (GERD), which is under construction and expected to be operational on the Blue Nile River in Ethiopia in a few years. Like many large-scale projects on transboundary rivers, the GERD has been criticized for potentially jeopardizing downstream water security and livelihoods through upstream unilateral decision making. In spite of the contentious nature of the project, the authors argue that this project can provide substantial benefits for regional development. The GERD, like any major river infrastructure project, will undeniably bring about social, environmental, and economic change, and in this unique case has, on balance, the potential to achieve success on all fronts. It must be stressed, however, that strong partnerships between riparian countries are essential. National success is contingent on regional cooperation.

  7. Cosmological implications of grand unified theories

    International Nuclear Information System (INIS)

    Nanopoulos, D.V.

    1982-01-01

    These lectures, mainly devoted to the cosmological implications of GUTs, also include the essential ingredients of GUTs and some of their important applications to particle physics. Section 1 contains some basic points concerning the structure of the standard strong and electroweak interactions prior to grand unification. A detailed expose of GUTs is attempted in sect. 2, including their basci principles and their consequences for particle physics. The minimal, simplest GUT, SU 5 is analysed in some detail and it will be used throughout these lectures as the GUT prototype. Finally, sect. 3 contains the most important cosmological implications of GUTs, including baryon number generation in the early Universe (in rather lengthy detail), dissipative processes in the very early Universe, grand unified monopoles, etc. (orig./HSI)

  8. The geology of Piz Pian Grand

    International Nuclear Information System (INIS)

    Huber, M.; Staeuble, J.

    1987-01-01

    Nagra has identified four potential sites for a repository for low- and intermediate-level waste. Exploration work is already underway at Oberbauenstock (UR) and Piz Pian Grand (GR). As part of the investigations in the Piz Pian Grand area, geological surface mapping was carried out between 1984 and 1987. Since the data obtained is still being evaluated, it would be premature to draw any interpretative conclusions at this stage. On the other hand, some of the most significant observations of this work can be summarised here. As a first step, the geological framework in which these investigations are to be seen should be defined. Observations will then be made on the rock content (lithology) and geometric structure (structural geology) of the area. (author) 6 figs

  9. Grand Gulf-prioritization of regulatory requirements

    International Nuclear Information System (INIS)

    Meisner, M.J.

    1993-01-01

    As cost pressures mount, Grand Gulf nuclear station (GGNS) is relying increasingly on various prioritization approaches to implement, modify, eliminate, or defer regulatory requirements. Regulatory requirements can be prioritized through the use of three measures: (1) safety (or risk) significance; (2) cost; and (3) public policy (or political) significance. This paper summarizes GGNS' efforts to implement solutions to regulatory issues using these three prioritization schemes to preserve a balance between cost and safety benefit

  10. Between two evils: Investors prefer grand corruption!

    OpenAIRE

    Graf Lambsdorff, Johann

    2005-01-01

    Recent empirical studies claim that, in addition to levels of corruption, investors are deterred by its unpredictability. I claim instead that it is petty corruption that deters investors. I employ seven subcomponents of corruption for a sample of 102 countries that appear in the 2003 Global Competitiveness Report of the WEF. The second principal component of this data depicts a grand, political type, embracing corruption in government policymaking and in judicial decisions as opposed to corr...

  11. Meliponiculture in Rio Grande do Norte

    Directory of Open Access Journals (Sweden)

    Ulysses Madureira Maia

    2015-12-01

    Full Text Available ABSTRACT. Maia U.M., Jaffe R., Carvalho A.T. & Imperatriz-Fonseca V.L. [Meliponiculture in Rio Grande do Norte.] Meliponicultura no Rio Grande do Norte. Revista Brasileira de Medicina Veterinária, 37(4:327-333, 2015. Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, SP 14040-901, Brasil. E-mail: ummaia@usp.br This study aimed to assess the current status of stingless bee beekeeping (meliponiculture in the State of Rio Grande do Norte, Brazil, with the aid of structured questionnaires made during visits to beekeepers. The results were compared with a previous census made in the state and with a similar study from Australia. Meliponiculture in Rio Grande do Norte is still informal and little standardized. The activity has grown in recent years considering the mean number of nests per beekeeper. Most apiaries are formed of up to 50 colonies, usually distributed in the backyards of homes. Twelve species of stingless bees were reared in the state, and the most common was the “Jandaíra” bee (Melipona subnitida, whose honey is considered medicinal. While many beekeepers already know the importance of bees as pollinators, stingless bees are still not used for crop pollination. Compared to a recent analysis of beekeeping in Australia, meliponiculture in Brazil is more traditional, honey is the main product and the number of colonies per beekeeper is much higher. Our results highlight the need to reinforce knowledge about bees and promote specific training aimed at improving and standardizing management practices.

  12. Neutrino mixing in a grand unified theory

    International Nuclear Information System (INIS)

    Milton, K.; Tanaka, K.

    1980-01-01

    Neutrino mixing in a grand unified theory in which the neutrino mass matrix is determined by the Gell-Mann-Ramond-Slansky mechanism was investigated. With an arbitrary real right-handed Majorana mass matrix which incorporates three neutrino mass scales, the effects of the up-quark mass matrix are found to be dominant and as a result no significant mixing of ν/sub e/ occurs, while ν/sub μ/ - ν/sub γ/ mixing can be substantial

  13. The Grand Strategy of Charles de Gaulle

    Science.gov (United States)

    1989-09-08

    4. TITLE AND SUBTITLE The Grand Startegy of Charles de Gaulle 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...dependent on French influence within NATO and the Common Market . De Gaulle frequently used these fora to veto British and American initiatives. As Cook...the reserve currency. Gold would be the basis of international finance and a French-dominated European Common Market would provide the framework

  14. [Grand Banks activity : updates and opportunities

    International Nuclear Information System (INIS)

    Bruce, G.

    1998-01-01

    An overview of the exploration and on-going activities by the petroleum industry on the Grand Banks of Newfoundland was presented. The two offshore oil developments underway are Hibernia and Terra Nova, both located in the Jeanne d'Arc Basin. Current production from Hibernia is 68,000 bopd, expected to rise to 130,000 bopd in 1999. The Terra Nova Field is still under development. Total recoverable reserves from the 17 discoveries made in the Jeanne d'Arc Basin are estimated at 1.6 billion barrels of oil and 4 trillion cubic feet of gas. Industry participants in the area include Amoco, Petro-Canada, Mobil, Chevron, Husky and Norsk Hydro. Petro-Canada believes the Grand Banks represent one of the best opportunities for oil anywhere in the world. There are currently 21 exploration licenses held on the Grand Banks. Major attractions of the area include the large reserve potential, the relatively low finding costs, the size of the pools being discovered, improvements in offshore technology that have substantially lowered development costs, and a profit-sensitive generic royalty regime that ensures reasonable rates of return for investors. figs

  15. Proton decay in grand unified theories

    International Nuclear Information System (INIS)

    Lucha, W.

    1984-01-01

    Interactions which violate the conservation of baryon and lepton number represent an intrinsic part of all grand unified theories (GUTs) of strong and electroweak interactions. These new interactions - predicted within the framework of GUTs - generate B and L violating four-fermion interactions via the exchange of superheavy particles which cannot be ascribed a well-defined baryon or lepton number. The effective coupling constant of these four-fermion interactions might be large enough to make the proton decay detectable by the present generation of experiments. In this review the basic concepts of conventional as well as supersymmetric GUTs relevant for proton decay are sketched. The baryon number violating sector of grand unified theories is discussed in more detail. Special emphasis is laid on the various selection rules arising as consequences of low-energy gauge invariance and supersymmetry for proton decay. These selection rules already determine the coarse pattern of the resulting decay modes and branching ratios without any reference to or detailed knowledge of the underlying grand unified theory. Finally the numerous theoretical predictions are summarized and confronted with experiment. (Author)

  16. Raptor Use of the Rio Grande Gorge

    Energy Technology Data Exchange (ETDEWEB)

    Ponton, David A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-20

    The Rio Grande Gorge is a 115 km long river canyon located in Southern Colorado (15 km) and Northern New Mexico (100 km). The majority of the canyon is under the administration of the Bureau of Land Management {BLM), and 77 km of the canyon south of the Colorado/New Mexico border are designated Wild River under the National Wild and Scenic Rivers Act of 1968. Visits I have made to the Rio Grande Gorge over the past 15 .years disclosed some raptor utilization. As the Snake River Birds of Prey Natural Area gained publicity, its similarity to the Rio Grande Gorge became obvious, and I was intrigued by the possibility of a high raptor nesting density in the Gorge. A survey in 1979 of 20 km of the northern end of the canyon revealed a moderately high density of red-tailed hawks and prairie falcons. With the encouragement of that partial survey, and a need to assess the impact of river-running on nesting birds of prey, I made a more comprehensive survey in 1980. The results of my surveys, along with those of a 1978 helicopter survey by the BLM, are presented in this report, as well as general characterization of the area, winter use by raptors, and an assessment of factors influencing the raptor population.

  17. Rapid Production Ramp-up for International Collaborative Supply Network in Electronics Goods Industry (X-Box, PS II, I-Pod, Etc) A Review of Existing Practices, Issues, and Challenges

    OpenAIRE

    Hu, Ning

    2006-01-01

    The fierce competition of international consumer electronics market has brought more pressures on the manufacturing section especially in the context of globalization. The global producers have to find effective solution to cope with the challenges such as shorter and shorter product life, less and less customer loyalty and resources limitation. The fact that rapid production ramp up and supply network collaboration could benefit their performance has been recognized by many business giants s...

  18. Future of Electron Scattering and Diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Hall, Ernest [GE Global Research, Niskayuna, New York (United States); Stemmer, Susanne [Univ. of California, Santa Barbara, CA (United States); Zheng, Haimei [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Zhu, Yimei [Brookhaven National Lab. (BNL), Upton, NY (United States); Maracas, George [Dept. of Energy (DOE), Washington DC (United States). Office of Science

    2014-02-25

    The ability to correlate the atomic- and nanoscale-structure of condensed matter with physical properties (e.g., mechanical, electrical, catalytic, and optical) and functionality forms the core of many disciplines. Directing and controlling materials at the quantum-, atomic-, and molecular-levels creates enormous challenges and opportunities across a wide spectrum of critical technologies, including those involving the generation and use of energy. The workshop identified next generation electron scattering and diffraction instruments that are uniquely positioned to address these grand challenges. The workshop participants identified four key areas where the next generation of such instrumentation would have major impact: A – Multidimensional Visualization of Real Materials B – Atomic-scale Molecular Processes C – Photonic Control of Emergence in Quantum Materials D – Evolving Interfaces, Nucleation, and Mass Transport Real materials are comprised of complex three-dimensional arrangements of atoms and defects that directly determine their potential for energy applications. Understanding real materials requires new capabilities for three-dimensional atomic scale tomography and spectroscopy of atomic and electronic structures with unprecedented sensitivity, and with simultaneous spatial and energy resolution. Many molecules are able to selectively and efficiently convert sunlight into other forms of energy, like heat and electric current, or store it in altered chemical bonds. Understanding and controlling such process at the atomic scale require unprecedented time resolution. One of the grand challenges in condensed matter physics is to understand, and ultimately control, emergent phenomena in novel quantum materials that necessitate developing a new generation of instruments that probe the interplay among spin, charge, orbital, and lattice degrees of freedom with intrinsic time- and length-scale resolutions. Molecules and soft matter require imaging and

  19. LEP constraints on grand unified theories

    International Nuclear Information System (INIS)

    Sarkar, Utpal

    1993-01-01

    Recent developments on grand unified theories (GUTs) in the context of the LEP measurements of the coupling constants are reviewed. The three coupling constants at the electroweak scale have been measured at LEP quite precisely. One can allow these couplings to evolve with energy following the renormalization group equations for the various groups and find out whether all the coupling constants meet at any energy. It was pointed out that the minimal SU(5) grand unified theory fails to satisfy this test. However, various extensions of the theory are still allowed. These extensions include (i) supersymmetric SU(5) GUT, with some arbitrariness in the susy breaking scale arising from the threshold corrections, (ii) non-susy SU(5) GUTs with additional fermions as well as Higgs multiplets, which has masses of the order of TeV, and (iii) non-renormalizable effect of gravity with a fine tuned relation among the coupling constants at the unification energy. The LEP results also constrain GUTs with an intermediate symmetry breaking scale. By adjusting the intermediate symmetry breaking scale, one usually can have unification, but these theories get constrained. For example, the left-right symmetric theories coming from GUTs can be broken only at energies higher than about ∼10 10 GeV. This implies that if right handed gauge bosons are found at energies lower than this scale, then that will rule out the possibility of grand unification. Another recent interesting development on the subject, namely, low energy unification, is discussed in this context. All the coupling constants are unified at energies of the order of ∼10 8 GeV when they are embedded in an SU(15)GUT, with some particular symmetry breaking pattern. But even in this case the results of the intermediate symmetry breaking scale remain unchanged. (author). 16 refs., 3 figs

  20. Maternal and fetal outcome in grand multipara

    International Nuclear Information System (INIS)

    Qamar, A.; Qamar, S.

    2015-01-01

    Study Design: Case control study. Place and Duration of Study: Gynecology and Obstetric Unit-I of the Jinnah Post Graduate and Medical Centre Karachi, from February 2009 to January 2010. Patients and Methods: One hundred (100) patients of grand multipara (GMP), (parity = 5) and 100 patients of multipara (MP) (parity 2-4) were included in the study. Pregnant women with known medical conditions including essential hypertension, diabetes mellitus, epilepsy, primigravidas, women with previous caesarean section and twin pregnancies were excluded. Patients were admitted through antenatal clinic and emergency. A detailed history was taken and a physical examination was done with special emphasis on obstetrical examination. Investigations like blood CP, Urine D/R, blood grouping and sonogram were done. During labour, mother and neonates were managed according to ward protocols. Maternal and fetal outcomes were compared among GMPs and MPs. Results: A high frequency of anaemia (81% vs 20%), pregnancy induced hypertension (45%, vs. 26%) and gestational diabetes (9%, vs1%) were seen in GMP as compared to MP group. Frequency of malpresentations (26% vs 15%), postpartum hemorrhage (15%, vs 10%) and intrauterine deaths (26%, vs 13%) were higher in GMP group along with a high caesarean delivery rate (GMP 21%, MP 14%). A higher maternal mortality (GMP 4%, MP 1%) and low APGAR score (GMP 12%, MP 4%) were observed among babies born to grand multipara group. Conclusion: Grand multiparity is associated with adverse outcome for both mother and fetus. Effort should be directed to reduce high parity in the community through effective family planning initiatives. Specialized antenatal and obstetrical care facilities should be available. (author)

  1. Applying Systems Engineering on Energy Challenges

    NARCIS (Netherlands)

    Safi, J.; Muller, G.; Bonnema, Gerrit Maarten

    2012-01-01

    Systems engineering is a discipline with methods and techniques to address complex problems. We want to study how Systems Engineering methods can help to address today's grand challenges, such as the energy problem. The first step is problem definition which aims at articulating the problem in its

  2. Lie groups and grand unified theories

    International Nuclear Information System (INIS)

    Gubitoso, M.D.

    1987-01-01

    This work presents some concepts in group theory and Lie algebras and, at same time, shows a method to study and work with semisimple Lie groups, based on Dynkin diagrams. The aproach taken is not completely formal, but it presents the main points of the elaboration of the method, so its mathematical basis is designed with the purpose of making the reading not so cumbersome to those who are interested only in a general picture of the method and its usefulness. At the end it is shown a brief review of gauge theories and two grand-unification models based on SO(13) and E 7 gauge groups. (author) [pt

  3. Grand Canonical Ensembles in General Relativity

    International Nuclear Information System (INIS)

    Klein, David; Yang, Wei-Shih

    2012-01-01

    We develop a formalism for general relativistic, grand canonical ensembles in space-times with timelike Killing fields. Using that, we derive ideal gas laws, and show how they depend on the geometry of the particular space-times. A systematic method for calculating Newtonian limits is given for a class of these space-times, which is illustrated for Kerr space-time. In addition, we prove uniqueness of the infinite volume Gibbs measure, and absence of phase transitions for a class of interaction potentials in anti-de Sitter space.

  4. Produccion de plantas grandes usando minicontenedores

    Science.gov (United States)

    R. Kasten Dumroese; Thomas D. Landis

    2012-01-01

    En América del Norte hay cada vez más interés por la producción híbrida o mixta. La misma consiste en cultivar plantines en contenedores de pequeño volumen y luego trasplantarlos; el trasplante se puede realizar a canteros en el suelo como en la producción a raíz desnuda o bien a contenedores más grandes. Originalmente se llamaban plantines "plug+", "...

  5. Challenges regarding the start-up of an anaerobic biological sulphate reactor using H2 and CO2 as electron donor and carbon sources

    CSIR Research Space (South Africa)

    Roux, SP

    2009-05-01

    Full Text Available Include neutralization and chemical precipitation as well as membrane dependent processes. Biological sulphate reduction is another, environmentally benign option but relies heavily on the availability of an economically viable electron donor...

  6. The Grand Duchy on the Grand Tour: A Historical Study of Student Migration in Luxembourg

    Science.gov (United States)

    Rohstock, Anne; Schreiber, Catherina

    2013-01-01

    Since Luxembourg became independent in 1839, practically the entire political, economic and intellectual elite of the country has been socialised abroad. It was only in 2003 that the Grand Duchy set up its own university; before then, young Luxembourgers had to study in foreign countries. Over the past 150 years, Luxembourg has thus experienced…

  7. Precision measurement of the cross section of charged-current and neutral current processes at large Q{sup 2} at HERA with the polarized-electron beam; Mesures de precision de la section efficace des processus courant charge et courant neutre a grand Q{sup 2} a HERA avec le faisceau d'electrons polarises

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Trong Hieu

    2011-04-15

    The inclusive cross sections for both charged and neutral current processes have been measured in interactions of longitudinally polarized electrons (positrons) with unpolarized protons using the full data samples collected by H1 at HERA-II. The data taken at a center-of-mass energy of 319 GeV correspond to an integrated luminosity of 149.1 pb{sup -1} and 180.0 pb{sup -1} for e{sup -}p and e{sup +}p collisions, representing an increase in statistics of a factor of 10 and 2, respectively, over the data from HERA-I. The measured double differential cross sections d{sup 2}{sigma}/dxdQ{sup 2} cover more than two orders of magnitude in both Q{sup 2}, the negative four-momentum transfer squared, up to 30000 GeV{sup 2}, and Bjorken x, down to 0.003. The cross section data are compared to predictions of the Standard Model which is able to provide a good description of the data. The polarization asymmetry as a function of Q{sup 2} is measured with improved precision, confirming the previous observation of P violation effect in neutral current ep scattering at distances down to 10{sup -18} m. The total cross sections of the charged current process, for Q{sup 2} > 400 GeV{sup 2} and inelasticity y < 0.9 are measured for 4 independent data samples with e{sup {+-}} beams and different polarization values. Together with the corresponding cross section obtained from the previously published unpolarized data, the polarization dependence of the charged current cross section is measured and found to be in agreement with the Standard Model prediction with the absence of right-handed charged current. The cross sections are combined with previously published data from H1 to obtain the most precise unpolarized measurements. These are used to extract the structure function xF{sub 3}{sup {gamma}}{sup Z} which is sensitive to the valence quark distributions down to low x values. The new cross sections have also been used in a combined electroweak and QCD fit to significantly improve the

  8. 28 milliards d’euros, c’est grand comment ?

    OpenAIRE

    Ozer, Pierre; Salmon, Marc; Theunissen, Yannick

    2009-01-01

    J’ouvre mon quotidien. Fortis : 28 milliards d’euros de pertes en 2008. Ma fille de sept ans qui commence à lire et pose sans cesse des questions sur tout me lance : « Dis-moi, papa : 28 milliards d’euros, c’est grand comment ? ». Grande question… Je réfléchis et tente de trouver une parade parlante pour un enfant qui, in fine, se pose les mêmes questions que les grandes personnes.

  9. Gamma ray and neutrino detector facility (GRANDE), Task C

    International Nuclear Information System (INIS)

    Sobel, H.W.; Yodh, G.B.

    1991-08-01

    GRANDE is an imaging, water Cerenkov detector, which combines in one facility an extensive air shower array and a high-energy neutrino detector. We proposed that the detector be constructed in phases, beginning with an active detector area of 31,000 m 2 (GRANDE-I) 2 and expanding to a final size of 100,000--150,00 m 2 . Some of the characteristics of GRANDE-I are discussed in this paper

  10. O conservadorismo patronal da grande imprensa brasileira

    Directory of Open Access Journals (Sweden)

    Fonseca Francisco

    2003-01-01

    Full Text Available Através da análise da opinião dos editoriais dos quatro principais periódicos diários da grande imprensa, isto é, o Jornal do Brasil, O Globo, a Folha de S. Paulo e O Estado de S. Paulo - aqui considerados "aparelhos privados de hegemonia" -, este artigo procura desvendar os posicionamentos adotados perante a ordem social na Constituinte de 1987/1988, que também contribuem para compreender a reação à Consolidação das Leis do Trabalho. Observa-se, além do mais, as estratégias utilizadas para sua consecução. Conclui-se que, por mecanismos diversos, a grande imprensa contribuiu decisivamente para a introdução da agenda ideológica neoliberal no país, pois atuou de forma a "divulgar e vulgarizar" as idéias pertinentes a este ideário e de forma militantemente conservadora e patronal.

  11. Aprovechamiento de Salto Grande Argentina – Uruguay

    Directory of Open Access Journals (Sweden)

    Bongiovanni, M.

    1979-12-01

    Full Text Available The power harnessing of Salto Grande will be the first common project carried out by two South American Countries and this will foster greater integration of both countries. The project involves the following: — One 39 m-high dam — Two hydroelectric power plants — One international bridge — One shipping canal The benefits to be obtained from the project include: increase and improvement of the waterway network; increase of electricity production; railways and highway tie-ups between both countries; industrial development; increased availability of irrigation water; new tourist resorts; increase of fishing resources.

    El aprovechamiento hidroeléctrico de Salto Grande será el primer aprovechamiento común a dos países sudamericanos, lo que permitirá una mayor integración entre ellos. Consta de las siguientes obras: _ una presa de 39 m de altura; _ dos centrales hidroeléctricas; _ un puente internacional; _ un canal de navegación, etc. Entre los beneficios que se obtendrán destacan: aumento y mejora de la red de navegación; aumento de la producción eléctrica; enlace de las vías de ferrocarril y carreteras entre los dos países; desarrollo industrial; aumento de la disponibilidad de agua de riego; creación de zonas de turismo, e incremento de la riqueza piscícola.

  12. Estimating large complex projects Estimando proyectos grandes y complejos

    Directory of Open Access Journals (Sweden)

    Cliff Schexnayder

    2007-08-01

    Full Text Available Managing large capital construction projects requires the coordination of a multitude of human, organizational, technical, and natural resources. Quite often, the engineering and construction complexities of such projects are overshadowed by economic, societal, and political challenges. The ramifications and effects, which result from differences between early project cost estimates and the bid price or the final project cost, are significant. Over the time span between the initiation of a project and the completion of construction many factors influence a project's final costs. This time span is normally several years in duration but for highly complex and technologically challenging projects, project duration can easily exceed a decade. Over that period, changes to the project scope often occur. The subject here is a presentation of strategies that support realistic cost estimating. Through literature review and interviews with transportation agencies in the U.S. and internationally the authors developed a database of the factors that are the root causes of cost estimation problemsGestionar proyectos de construcción de grandes capitales requiere de la coordinación de una multitud de recursos humanos, organizacionales, técnicos y naturales. Frecuentemente, las complejidades del diseño y construcción de esos grandes proyectos son tapadas por sus desafíos económicos, políticos y sociales. Las ramificaciones y efectos que resultan de las diferencias entre la estimación de costo inicial, el costo de la propuesta adjudicada y el costo final del proyecto son significativas. Hay numerosos factores que inciden en el costo final del proyecto entre su inicio y finalización. La duración es generalmente de varios años y puede incluso superar la década para aquellos especialmente complejos y desafiantes. En ese período de tiempo, cambios en los alcances del proyecto cambian frecuentemente. El tópico del presente artículo es mostrar

  13. La masa de los grandes impactores

    Science.gov (United States)

    Parisi, M. G.; Brunini, A.

    Los planetas han sido formados fundamentalmente acretando masa a través de colisiones con planetesimales sólidos. La masa más grande de la distribución de planetesimales y las masas máxima y mínima de los impactores, han sido calculadas usando los valores actuales del período y de la inclinación de los planetas (Lissauer & Safronov 1991; Parisi & Brunini 1996). Recientes investigaciones han mostrado, que las órbitas de los planetas gigantes no han sufrido variaciones con el tiempo, siendo su movimiento regular durante su evolución a partir de la finalización de la etapa de acreción (Laskar 1990, 1994). Por lo tanto, la eccentricidad actual de los planetas gigantes se puede utilizar para imponer una cota máxima a las masas y velocidades orbitales de los grandes impactores. Mediante un simple modelo dinámico, y considerando lo arriba mencionado, obtenemos la cota superior para la masa del planetesimal más grande que impactó a cada planeta gigante al final de su etapa de acreción. El resultado más importante de este trabajo es la estimación de la masa máxima permitida para impactar a Júpiter, la cúal es ~ 1.136 × 10 -1, siendo en el caso de Neptuno ~ 3.99 × 10 -2 (expresada en unidades de la masa final de cada planeta). Además, fue posible obtener la velocidad orbital máxima permitida para los impactores como una función de su masa, para cada planeta. Las cotas obtenidas para la masa y velocidad de los impactores de Saturno y Urano (en unidades de la masa y velocidad final de cada planeta respectivamente) son casi las mismas que las obtenidas para Júpiter debido a que estos tres planetas poseen similar eccentricidad actual. Nuestros resultados están en buen acuerdo con los obtenidos por Lissauer & Safronov (1991). Estas cotas podrían ser utilizadas para obtener la distribución de planetesimales en el Sistema Solar primitivo.

  14. The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records : evaluations of two exemplar trials

    NARCIS (Netherlands)

    van Staa, Tjeerd-Pieter; Dyson, Lisa; McCann, Gerard; Padmanabhan, Shivani; Belatri, Rabah; Goldacre, Ben; Cassell, Jackie; Pirmohamed, Munir; Torgerson, David; Ronaldson, Sarah; Adamson, Joy; Taweel, Adel; Delaney, Brendan; Mahmood, Samhar; Baracaia, Simona; Round, Thomas; Fox, Robin; Hunter, Tommy; Gulliford, Martin; Smeeth, Liam

    BACKGROUND: Pragmatic trials compare the effects of different decisions in usual clinical practice. OBJECTIVES: To develop and evaluate methods to implement simple pragmatic trials using routinely collected electronic health records (EHRs) and recruiting patients at the point of care; to identify

  15. Microfluidic electronics.

    Science.gov (United States)

    Cheng, Shi; Wu, Zhigang

    2012-08-21

    Microfluidics, a field that has been well-established for several decades, has seen extensive applications in the areas of biology, chemistry, and medicine. However, it might be very hard to imagine how such soft microfluidic devices would be used in other areas, such as electronics, in which stiff, solid metals, insulators, and semiconductors have previously dominated. Very recently, things have radically changed. Taking advantage of native properties of microfluidics, advances in microfluidics-based electronics have shown great potential in numerous new appealing applications, e.g. bio-inspired devices, body-worn healthcare and medical sensing systems, and ergonomic units, in which conventional rigid, bulky electronics are facing insurmountable obstacles to fulfil the demand on comfortable user experience. Not only would the birth of microfluidic electronics contribute to both the microfluidics and electronics fields, but it may also shape the future of our daily life. Nevertheless, microfluidic electronics are still at a very early stage, and significant efforts in research and development are needed to advance this emerging field. The intention of this article is to review recent research outcomes in the field of microfluidic electronics, and address current technical challenges and issues. The outlook of future development in microfluidic electronic devices and systems, as well as new fabrication techniques, is also discussed. Moreover, the authors would like to inspire both the microfluidics and electronics communities to further exploit this newly-established field.

  16. Local grand unification and string theory

    International Nuclear Information System (INIS)

    Nilles, Hans Peter; Vaudrevange, Patrick K.S.

    2009-09-01

    The low energy effective action of string theory depends strongly on the process of compactification and the localization of fields in extra dimensions. Explicit string constructions towards the minimal supersymmetric standard model (MSSM) reveal interesting results leading to the concept of local grand unification. Properties of the MSSM indicate that we might live at a special location close to an orbifold fixed point rather than a generic point in Calabi-Yau moduli space. We observe an enhancement of (discrete) symmetries that have various implications for the properties of the MSSM such as proton stability as well as solutions to the flavor problem, the m-problem and the strong CP-problem. (orig.)

  17. A unified grand tour of theoretical physics

    CERN Document Server

    Lawrie, Ian D

    2013-01-01

    A Unified Grand Tour of Theoretical Physics invites its readers to a guided exploration of the theoretical ideas that shape our contemporary understanding of the physical world at the fundamental level. Its central themes, comprising space-time geometry and the general relativistic account of gravity, quantum field theory and the gauge theories of fundamental forces, and statistical mechanics and the theory of phase transitions, are developed in explicit mathematical detail, with an emphasis on conceptual understanding. Straightforward treatments of the standard models of particle physics and cosmology are supplemented with introductory accounts of more speculative theories, including supersymmetry and string theory. This third edition of the Tour includes a new chapter on quantum gravity, focusing on the approach known as Loop Quantum Gravity, while new sections provide extended discussions of topics that have become prominent in recent years, such as the Higgs boson, massive neutrinos, cosmological perturba...

  18. Introduction to Grand Unified Theories. 12

    International Nuclear Information System (INIS)

    Wali, K.C.

    1989-01-01

    This chapter presents an introduction into Grand Unified Theories. After a discussion of the general features to be expected in any such theory, and of the motivations for them, a detailed presentation of SU(5) theory is given. The group structures, particle multiplets, gauge and Higgs bosons are explained. The two stages of spontaneous symmetry breaking via the Higgs model, are calculated individually and in combination. Fermion mass matrices and relations between quark and lepton masses are derived. predictions of SU(5) theory, calculated using renormalization group methods, are derived. The chapter ends with discussions that bring together particle physics and cosmology, including the baryon asymmetry problem, phase transitions in the very early universe, and singularities like domain walls, vortex lines and monopoles. (author). 9 refs.; 4 figs.; 5 tabs

  19. Supersymmetric grand unified theories and cosmology

    International Nuclear Information System (INIS)

    Lazarides, G.; Shafi, Q.

    1983-01-01

    By examining the behavior of supersymmetric grand unified theories (GUT's) in the very early universe we find two classes of realistic models. In one of them supersymmetry is broken at or near superheavy GUT scale. The cosmological implications of such models are expected to be similar to those of nonsupersymmetric GUT's. In the second class of models, the superheavy GUT scale is related to the supersymmetry-breaking scale in the manner of Witten. Two types of cosmological scenarios appear possible in this case, either with or without an intermediate (new) inflationary phase. They can be experimentally distinguished, since the former predicts an absence and the latter an observable number density of superheavy monopoles. A mechanism for generating baryon asymmetry in such models is pointed out

  20. Pitié pour les grandes villes !

    Directory of Open Access Journals (Sweden)

    Jérôme Monnet

    1997-02-01

    Full Text Available Roger Caillois disait, en 1938, qu´il existe "une représentation de la grande ville, assez puissante sur les imaginations pour que jamais en pratique ne soit posée la question de son exactitude, créée de toute pièce par le livre, assez répandue néanmoins pour faire partie de l´atmosphère mentale collective et posséder par suite une certaine force de contrainte"(Le mythe et l´homme, p.156 [c´est lui qui souligne]. En 1996, la presse française a consacré dossiers et articles à "Habitat II...

  1. Higgsless grand unified theory breaking and trinification

    International Nuclear Information System (INIS)

    Carone, Christopher D.; Conroy, Justin M.

    2004-01-01

    Boundary conditions on an extra dimensional interval can be chosen to break bulk gauge symmetries and to reduce the rank of the gauge group. We consider this mechanism in models with gauge trinification. We determine the boundary conditions necessary to break the trinified gauge group directly down to that of the standard model. Working in an effective theory for the gauge-symmetry-breaking parameters on a boundary, we examine the limit in which the grand-unified theory-breaking-sector is Higgsless and show how one may obtain the low-energy particle content of the minimal supersymmetric standard model. We find that gauge unification is preserved in this scenario, and that the differential gauge coupling running is logarithmic above the scale of compactification. We compare the phenomenology of our model to that of four dimensional 'trinified' theories

  2. Grand unified models including extra Z bosons

    International Nuclear Information System (INIS)

    Li Tiezhong

    1989-01-01

    The grand unified theories (GUT) of the simple Lie groups including extra Z bosons are discussed. Under authors's hypothesis there are only SU 5+m SO 6+4n and E 6 groups. The general discussion of SU 5+m is given, then the SU 6 and SU 7 are considered. In SU 6 the 15+6 * +6 * fermion representations are used, which are not same as others in fermion content, Yukawa coupling and broken scales. A conception of clans of particles, which are not families, is suggested. These clans consist of extra Z bosons and the corresponding fermions of the scale. The all of fermions in the clans are down quarks except for the standard model which consists of Z bosons and 15 fermions, therefore, the spectrum of the hadrons which are composed of these down quarks are different from hadrons at present

  3. Review of freeboard: Grand Rapids Generating Station

    Energy Technology Data Exchange (ETDEWEB)

    Groeneveld, J.L.; Harding, W.B.; Bonin, D.V.; Fuchs, D.M. [Acres Manitoba Ltd., Winnipeg, MB (Canada); Warner, B.J. [Manitoba Hydro, Winnipeg, MB (Canada)

    2001-10-01

    Constructed during the period 1960-1965, the Grand Rapids Generating Station is a 472 MW hydroelectric station located approximately 400 kilometres northwest of Winnipeg, Manitoba, on the Saskatchewan River. An intake structure, four penstocks, a four-unit plus house unit powerhouse, wing walls, extensive dyke structures and a four-bay spillway are the components of the generating station. A little over ten years ago, the Manitoba Hydro Dam Safety Program was initiated. The program included a detailed dam safety review of the Grand rapids Generating Station. A potential deficiency in the freeboard allowance for several of the earthen dykes was revealed by the review process. The dam safety guidelines sponsored by the Canadian Dam Association were not met. The occurrence of a 1:1000 year wind event from the critical direction when the reservoir was at or near its full supply level was compounded by the analysis. The establishment of a wind and wave monitoring program was included in the deficiency studies commissioned. The objective was to confirm the empirical estimates concerning wave height, the development and usage of a two dimensional numerical wave model, and additional freeboard analyses to refine estimates of the recurrence interval of the current level of protection. A statistical Monte Carlo analysis was performed in the case of the estimates of the recurrence interval to determine the joint probabilities of seasonal variations in wind direction, wind speed, and reservoir level. The estimate of the actual risk of overtopping was therefore refined, and the details pertaining to the methodology and the conclusions of the analysis are all included in the paper. 15 refs., 4 tabs., 9 figs.

  4. Perspective view over the Grand Canyon, Arizona

    Science.gov (United States)

    2001-01-01

    This simulated true color perspective view over the Grand Canyon was created from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data acquired on May 12, 2000. The Grand Canyon Village is in the lower foreground; the Bright Angel Trail crosses the Tonto Platform, before dropping down to the Colorado Village and then to the Phantom Ranch (green area across the river). Bright Angel Canyon and the North Rim dominate the view. At the top center of the image the dark blue area with light blue haze is an active forest fire. ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. The broad spectral coverage and high spectral resolution of ASTER provides scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance. The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate. Size: 5 km in foreground to 40 km Location: 36.3 degrees north latitude, 112 degrees west longitude Orientation: North-northeast at top Original Data Resolution: ASTER 15 meters Dates Acquired: May 12, 2000

  5. Cognitive Challenges

    Science.gov (United States)

    ... Privacy Policy Sitemap Learn Engage Donate About TSC Cognitive Challenges Approximately 45% to 60% of individuals with TSC develop cognitive challenges (intellectual disabilities), although the degree of intellectual ...

  6. Phase transitions at finite chemical potential in grand unified theories

    International Nuclear Information System (INIS)

    Bailin, D.; Love, A.

    1984-01-01

    We discuss the circumstances in which non-zero chemical potentials might prevent symmetry restoration in phase transitions in the early universe at grand unification or partial unification scales. The general arguments are illustrated by consideration of SO(10) and SU(5) grand unified theories. (orig.)

  7. Fetal Outcomes among Grand Multiparous and Multiparous Women ...

    African Journals Online (AJOL)

    Objective: To compare fetal outcomes among grand multiparous (para 5-9) and multiparous (para 2-4) delivering in Mulago hospital, Uganda. Design: Prospective cohort study. Setting: Mulago hospital, Uganda. Subjects: One hundred and fifty six grand multiparous and multiparous women were recruited on admission in ...

  8. First report of Phytophthora ramorum infecting grand fir in California

    Science.gov (United States)

    K.L. Riley; G.A. Chastagner

    2011-01-01

    Phytophthora ramorum was detected on grand fir in 2003 and 2005 in a Christmas tree plantation near Los Gatos, CA, in association with infected California bay laurel. Isolates derived from stem lesions were used to inoculate grand fir seedlings in two tests. Isolations from lesions on inoculated plants were positive for P. ramorum...

  9. Plants, arthropods, and birds of the Rio Grande [chapter 7

    Science.gov (United States)

    Deborah M. Finch; Gale L. Wolters; Wang Yong; Mary Jean Mund

    1995-01-01

    Human populations have increased dramatically along the Rio Grande since European settlement. Human use of water for irrigation and consumption, and human use of land for agriculture, urban centers, livestock grazing, and recreation have changed Rio Grande ecosystems by altering flood cycles, channel geomorphology, upslope processes, and water quality and quantity....

  10. Research of the Rio Grande Ecosystem Management Program

    Science.gov (United States)

    Deborah M. Finch

    2000-01-01

    This paper describes the mission, objectives, and preliminary results of the Middle Rio Grande Ecosystem Management Research Program managed at the Rocky Mountain Research Station's Albuquerque laboratory. This program was initiated in 1994 to address growing pressures to effectively manage the limited resources of the middle Rio Grande Basin. The program is...

  11. Elastoplasticidad anisotropa de metales en grandes deformaciones

    Science.gov (United States)

    Caminero Torija, Miguel Angel

    El objetivo de este trabajo es el desarrollo de modelos y algoritmos numericos que simulen el comportamiento del material bajo estas condiciones en el contexto de programas de elementos finitos, dando como resultado predicciones mas precisas de los procesos de conformado y deformacion plastica en general. Para lograr este objetivo se han desarrollado diversas tareas destinadas a mejorar las predicciones en tres aspectos fundamentales. El primer aspecto consiste en la mejora de la descripcion del endurecimiento cinematico anisotropo en pequenas deformaciones, lo cual se ha realizado a traves de modelos y algoritmos implicitos de superficies multiples. Ha sido estudiada la consistencia de este tipo de modelos tanto si estan basados en una regla implicita similar a la de Mroz o en la regla de Prager. Ademas se han simulado los ensayos de Lamba y Sidebottom, obteniendo, en contra de la creencia general, muy buenas predicciones con la regla de Prager. Dichos modelos podrian ser extendidos de forma relativamente facil para considerar grandes deformaciones a traves de procedimientos en deformaciones logaritmicas, similares a los desarrollados en esta tesis y detallados a continuacion. El segundo aspecto consiste en la descripcion de la anisotropia elastoplastica inicial. Esto se ha conseguido mediante el desarrollo de modelos y algoritmos para plasticidad anisotropa en grandes deformaciones, bien ignorando la posible anisotropia elastica, bien considerandola simultaneamente con la anisotropia plastica. Para ello ha sido necesario desarrollar primero un nuevo algoritmo de elastoplasticidad anisotropa en pequenas deformaciones consistentemente linealizado y sin despreciar ningun termino, de tal forma que se conserve la convergencia cuadratica de los metodos de Newton. Este algoritmo en pequenas deformaciones ha servido para realizar la correccion plastica de dos algoritmos en grandes deformaciones. El primero de estos algoritmos es una variacion del clasico algoritmo de

  12. Sustainable Ammonia Synthesis – Exploring the scientific challenges associated with discovering alternative, sustainable processes for ammonia production

    Energy Technology Data Exchange (ETDEWEB)

    Nørskov, Jens [Stanford Univ., CA (United States); ; SLAC National Accelerator Lab., Menlo Park, CA (United States); Chen, Jingguang [Columbia Univ., New York, NY (United States); Brookhaven National Lab. (BNL), Upton, NY (United States); Miranda, Raul [Dept. of Energy (DOE), Washington DC (United States). Office of Science; Fitzsimmons, Tim [Dept. of Energy (DOE), Washington DC (United States). Office of Science; Stack, Robert [Dept. of Energy (DOE), Washington DC (United States). Office of Science

    2016-02-18

    Ammonia (NH3) is essential to all life on our planet. Until about 100 years ago, NH3 produced by reduction of dinitrogen (N2) in air came almost exclusively from bacteria containing the enzyme nitrogenase.. DOE convened a roundtable of experts on February 18, 2016. Participants in the Roundtable discussions concluded that the scientific basis for sustainable processes for ammonia synthesis is currently lacking, and it needs to be enhanced substantially before it can form the foundation for alternative processes. The Roundtable Panel identified an overarching grand challenge and several additional scientific grand challenges and research opportunities: -Discovery of active, selective, scalable, long-lived catalysts for sustainable ammonia synthesis. -Development of relatively low pressure (<10 atm) and relatively low temperature (<200 C) thermal processes. -Integration of knowledge from nature (enzyme catalysis), molecular/homogeneous and heterogeneous catalysis. -Development of electrochemical and photochemical routes for N2 reduction based on proton and electron transfer -Development of biochemical routes to N2 reduction -Development of chemical looping (solar thermochemical) approaches -Identification of descriptors of catalytic activity using a combination of theory and experiments -Characterization of surface adsorbates and catalyst structures (chemical, physical and electronic) under conditions relevant to ammonia synthesis.

  13. A grand unified model for liganded gold clusters

    Science.gov (United States)

    Xu, Wen Wu; Zhu, Beien; Zeng, Xiao Cheng; Gao, Yi

    2016-12-01

    A grand unified model (GUM) is developed to achieve fundamental understanding of rich structures of all 71 liganded gold clusters reported to date. Inspired by the quark model by which composite particles (for example, protons and neutrons) are formed by combining three quarks (or flavours), here gold atoms are assigned three `flavours' (namely, bottom, middle and top) to represent three possible valence states. The `composite particles' in GUM are categorized into two groups: variants of triangular elementary block Au3(2e) and tetrahedral elementary block Au4(2e), all satisfying the duet rule (2e) of the valence shell, akin to the octet rule in general chemistry. The elementary blocks, when packed together, form the cores of liganded gold clusters. With the GUM, structures of 71 liganded gold clusters and their growth mechanism can be deciphered altogether. Although GUM is a predictive heuristic and may not be necessarily reflective of the actual electronic structure, several highly stable liganded gold clusters are predicted, thereby offering GUM-guided synthesis of liganded gold clusters by design.

  14. Grand unification and the double beta-decay

    International Nuclear Information System (INIS)

    Faessler, A.

    1992-01-01

    Models of the unification of the electroweak and the strong interaction predict that the neutrino is a Majorana particle and therefore essentially identical with its own antiparticle. In such grand unified models the neutrino has also a finite mass and a slight right-handed weak interaction, since the model is left-right symmetric. These models have also left handed and right-handed vector bosons to mediate the weak interactions. If these models are correct the neutrinoless double beta-decay is feasable. Thus if one finds the neutrinoless double beta-decay one knows that the standard model can not be correct in which the neutrino is a Dirac particle and therefore different from its antiparticle. Although the neutrinoless double beta-decay has not been seen it is possible to extract from the lower limits of the lifetime against the double neutrinoless beta-decay upper limits for the effective electron-neutrino mass and for the effective mixing angle of the right-handed and the left-handed vector bosons mediating the weak interaction. One also can obtain an effective upper limit for the mass ratio of the light and the heavy vector bosons. The extraction of this physical quantities from the data is made difficult due to the fact that the weak interaction must not be diagonal in the representation of the mass matrix of the six neutrinos requested by such left-right symmetric models. (author)

  15. Grande-Baie tugboat sinking and salvage operations

    International Nuclear Information System (INIS)

    Dussault, M.; Gauthier, F.

    2009-01-01

    This paper described the operations that took place during an oil spill that occurred in December 2007 when the Grande-Baie tugboat sank at the wharf in Port Alfred, in the Ha-Ha Bay on the Saguenay River, Quebec. Approximately 100 tonnes of diesel fuel was onboard the tug. Although the exact amount of diesel spilled during this event is not known, it is assumed that half of the ship's load in diesel was spilled into the ice-infested waters. Poor weather, the presence of pack ice and tides of 2.5 meters were present at the time. Two Canadian Coast Guard officers, one emergency officer from Environment Quebec and one from Environment Canada were called for response purposes, particularly to avoid spreading of the diesel fuel and to ensure that the oily water was recovered from inside the vessel during salvage operations. One of the key objectives was to prevent diesel spills by capping vessel vents, which proved to be very challenging. Oily water was pumped from inside the boat directly in the bay of the Saguenay River to facilitate salvage of the ship. This was the first time that this method was used in Canada, and was successful because of proper risk assessment. Many conditions were followed for the purpose of environmental protection, such as confinement, good observations by divers, agreed upon criteria to stop pumping, and adequate monitoring the the Regional Environmental Emergency Team (REET). The salvage operation lasted 19 days. The challenges associated with the migration and recovery of oil in icy waters were discussed along with the environmental issues associated with the spill, particularly with the imminent opening of the ice fishing season. 2 refs., 2 tabs.,5 figs.

  16. Paper electronics.

    Science.gov (United States)

    Tobjörk, Daniel; Österbacka, Ronald

    2011-05-03

    Paper is ubiquitous in everyday life and a truly low-cost substrate. The use of paper substrates could be extended even further, if electronic applications would be applied next to or below the printed graphics. However, applying electronics on paper is challenging. The paper surface is not only very rough compared to plastics, but is also porous. While this is detrimental for most electronic devices manufactured directly onto paper substrates, there are also approaches that are compatible with the rough and absorptive paper surface. In this review, recent advances and possibilities of these approaches are evaluated and the limitations of paper electronics are discussed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. EDMS implementation challenge.

    Science.gov (United States)

    De La Torre, Marta

    2002-08-01

    The challenges faced by facilities wishing to implement an electronic medical record system are complex and overwhelming. Issues such as customer acceptance, basic computer skills, and a thorough understanding of how the new system will impact work processes must be considered and acted upon. Acceptance and active support are necessary from Senior Administration and key departments to enable this project to achieve measurable success. This article details one hospital's "journey" through design and successful implementation of an electronic medical record system.

  18. Coordinating the Atlantis Grand Opening Event

    Science.gov (United States)

    Smith, Abigail Allaine

    2013-01-01

    While working as the marketing intern for Kennedy Space Center's (KSC) Center Planning and Development Directorate (CPD), I was given the opportunity not only to learn new skills and expand my work experience under the powerful influence of NASA, but I also was given the opportunity to prove that I am an individual capable of contributing to the KSC team. My main responsibility while working in CPD was to organize and run a booth that represented the entire directorate at the Grand Opening of the Shuttle Atlantis exhibit during the weekend of June 28-30. This event was important for CPD because as a Directorate that markets KSC's facilities, technical capabilities and technologies to potential partners, it is important to attend all events and use them to gain an understanding of our audience. Although we catered mostly to the general public during this event, it was still important to reach out to the larger space enthusiast community and let them know about KSC's future plans to become a multi-user spaceport and that teclmology is still being developed.

  19. The grand descent has begun for CMS

    CERN Multimedia

    2006-01-01

    Until recently, the CMS experimental cavern looked relatively empty; its detector was assembled entirely at ground level, to be lowered underground in 15 sections. On 2 November, the first hadronic forward calorimeter led the way with a grand descent. The first section of the CMS detector (centre of photo) arriving from the vertical shaft, viewed from the cavern floor. There is something unusual about the construction of the CMS detector. Instead of being built in the experimental cavern, like all the other detectors in the LHC experiments, it was constructed at ground level. This was to allow for easy access during the assembly of the detector and to minimise the size of the excavated cavern. The slightly nerve-wracking task of lowering it safely into the cavern in separate sections came after the complete detector was successfully tested with a magnetic field at ground level. In the early morning of 2 November, the first section of the CMS detector began its eagerly awaited descent into the underground ca...

  20. Local grand unification in the heterotic landscape

    International Nuclear Information System (INIS)

    Schmidt, Jonas

    2009-06-01

    We consider the possibility that the unification of the electroweak interactions and the strong force arises from string theory, at energies significantly lower than the string scale. As a tool, an effective grand unified field theory in six dimensions is derived from an anisotropic orbifold compactification of the heterotic string. It is explicitly shown that all anomalies cancel in the model, though anomalous Abelian gauge symmetries are present locally at the boundary singularities. In the supersymmetric vacuum additional interactions arise from higher-dimensional operators. We develop methods that relate the couplings of the effective theory to the location of the vacuum, and find that unbroken discrete symmetries play an important role for the phenomenology of orbifold models. An efficient algorithm for the calculation of the superpotential to arbitrary order is developed, based on symmetry arguments. We furthermore present a correspondence between bulk fields of the orbifold model in six dimensions, and the moduli fields that arise from compactifying four internal dimensions on a manifold with non-trivial gauge background. (orig.)

  1. Gauge hierarchy problem in grand unified theories

    International Nuclear Information System (INIS)

    Alhendi, H.A.A.

    1982-01-01

    In grand unification schemes, several mass scales are to be introduced, with some of them much larger than all the others, to cope with experimental observations, in which elementary particles of higher masses require higher energy to observe them than elementary particles of lower masses. There have been controversial arguments in the literature on such hierarchical scale structure, when radiative corrections are taken into account. It has been asserted that the gauge hierarchy depends on the choice of the subtraction point (in the classical field space), of the four-point function at zero external momentum. It also has been asserted that the gauge hierarchy problem whenever it is possible to be maintained in one sector of particles, it also is possible to be maintained in the other sectors. These two problems have been studied in a prototype model, namely an 0(3)-model with two triplets of real scalar Higgs fields. Our analysis shows that, within ordinary perturbation theory, none of these two problems is quite correct

  2. Integrated telemedicine workstation for intercontinental grand rounds

    Science.gov (United States)

    Willis, Charles E.; Leckie, Robert G.; Brink, Linda; Goeringer, Fred

    1995-04-01

    The Telemedicine Spacebridge to Moscow was a series of intercontinental sessions sponsored jointly by NASA and the Moscow Academy of Medicine. To improve the quality of medical images presented, the MDIS Project developed a workstation for acquisition, storage, and interactive display of radiology and pathology images. The workstation was based on a Macintosh IIfx platform with a laser digitizer for radiographs and video capture capability for microscope images. Images were transmitted via the Russian Lyoutch Satellite which had only a single video channel available and no high speed data channels. Two workstations were configured -- one for use at the Uniformed Services University of Health Sciences in Bethesda, MD. and the other for use at the Hospital of the Interior in Moscow, Russia. The two workstations were used may times during 16 sessions. As clinicians used the systems, we modified the original configuration to improve interactive use. This project demonstrated that numerous acquisition and output devices could be brought together in a single interactive workstation. The video images were satisfactory for remote consultation in a grand rounds format.

  3. Grand unification in the projective plane

    International Nuclear Information System (INIS)

    Hebecker, A.

    2004-01-01

    A 6-dimensional grand unified theory with the compact space having the topology of a real projective plane, i.e., a 2-sphere with opposite points identified, is considered. The space is locally flat except for two conical singularities where the curvature is concentrated. One supersymmetry is preserved in the effective 4d theory. The unified gauge symmetry, for example SU(5), is broken only by the non-trivial global topology. In contrast to the Hosotani mechanism, no adjoint Wilson-line modulus associated with this breaking appears. Since, locally, SU(5) remains a good symmetry everywhere, no UV-sensitive threshold corrections arise and SU(5)-violating local operators are forbidden. Doublet-triplet splitting can be addressed in the context of a 6d N=2 super Yang-Mills theory with gauge group SU(6). If this symmetry is first broken to SU(5) at a fixed point and then further reduced to the standard model group in the above non-local way, the two light Higgs doublets of the MSSM are predicted by the group-theoretical and geometrical structure of the model. (author)

  4. y las grandes ciudades: 1970-2004

    Directory of Open Access Journals (Sweden)

    Adrián de León Arias

    2008-01-01

    Full Text Available El cambio regional en las manufacturas mexicanas a partir de la década de 1980 se ha caracterizado por el rápido crecimiento del empleo y la producción en la frontera norte del país y la pérdida de participación de ellos en las grandes ciudades. En este artículo se analiza y evalúa este cambio regional en términos de la dinámica de la productividad laboral y factorial total para ambas configuraciones espaciales, presentando cálculos de productividad para éstas de 1970 a 2004, estimados a partir de la información censal. Los resultados sugieren que mientras el empleo ha crecido en magnitud mucho más rápido en la frontera norte, esta dinámica se ha generado con bajos niveles en crecimiento de la productividad, al menos hasta fechas recientes, por lo que el cambio regional estimulado por la apertura comercial hasta 2004 no parece haber facilitado un crecimiento económico más acelerado para México

  5. Local grand unification in the heterotic landscape

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Jonas

    2009-07-15

    We consider the possibility that the unification of the electroweak interactions and the strong force arises from string theory, at energies significantly lower than the string scale. As a tool, an effective grand unified field theory in six dimensions is derived from an anisotropic orbifold compactification of the heterotic string. It is explicitly shown that all anomalies cancel in the model, though anomalous Abelian gauge symmetries are present locally at the boundary singularities. In the supersymmetric vacuum additional interactions arise from higher-dimensional operators. We develop methods that relate the couplings of the effective theory to the location of the vacuum, and find that unbroken discrete symmetries play an important role for the phenomenology of orbifold models. An efficient algorithm for the calculation of the superpotential to arbitrary order is developed, based on symmetry arguments. We furthermore present a correspondence between bulk fields of the orbifold model in six dimensions, and the moduli fields that arise from compactifying four internal dimensions on a manifold with non-trivial gauge background. (orig.)

  6. Constraints on grand unified superstring theories

    International Nuclear Information System (INIS)

    Ellis, J.; Lopez, J.L.; Nanopoulos, D.V.; Houston Advanced Research Center

    1990-01-01

    We evaluate some constraints on the construction of grand unified superstring theories (GUSTs) using higher level Kac-Moody algebras on the world-sheet. In the most general formulation of the heterotic string in four dimensions, an analysis of the basic GUST model-building constraints, including a realistic hidden gauge group, reveals that there are no E 6 models and any SO(10) models can only exist at level-5. Also, any such SU(5) models can exist only for levels 4≤k≤19. These SO(10) and SU(5) models risk having many large, massless, phenomenologically troublesome representations. We also show that with a suitable hidden sector gauge group, it is possible to avoid free light fractionally charged particles, which are endemic to string derived models. We list all such groups and their representations for the flipped SU(5)xU(1) model. We conclude that a sufficiently binding hidden sector gauge group becomes a basic model-building constraint. (orig.)

  7. A unified grand tour of theoretical physics

    CERN Document Server

    Griffiths, J

    2002-01-01

    Anyone offering a grand tour is faced with several options. Should they concentrate on what may be considered to be essential features, or should they attempt to present a brief glimpse of almost everything? The present offering is a compromise between these two extremes. The area considered - theoretical physics - is now such a vast subject that some kind of compromise is essential. Indeed, the field is now so wide that few could even attempt to review it in a single-authored work. My task here is to assess how well this book has succeeded in its main aim of providing a unified (though introductory) tour of this subject. Constrained within a single volume, this is clearly not an updated Landau-Lifschitz. It cannot be expected to take any particular topic to the level of recent research. Nevertheless, it does seem to cover the broad range of essential topics which now constitute the subject. It starts (most appropriately in my opinion) with geometry. It then covers classical physics, general relativity and qu...

  8. Electronic Paramagnetic Resonance of irradiated nails: challenges for a dosimetry in radiation accidents; Ressonancia Paramagnetica Eletronica de unhas irradiadas: desafios para uma dosimetria em acidentes radiologicos

    Energy Technology Data Exchange (ETDEWEB)

    Giannoni, Ricardo A., E-mail: giannoni@ird.gov.br [Instituto de Radioprotecao e Dosimetria, (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Rodrigues Junior, Orlando [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2014-07-01

    The purpose of this work is to characterize samples of human nails exposed to high doses of radiation, applying the technique of Electron Paramagnetic Resonance (EPR). The objective is to establish a dose response study that allow determine the absorbed dose by exposed individuals in situations of radiological accidents, in a retrospective form. Samples of human nails were collected and afterward irradiated with gamma radiation, and received dose of 20 Gy. The EPR measurement performed on the samples, before irradiation, permitted the signal identification of the components associated with effects caused by the mechanical stress during the fingernail cutting, the so-called mechanically induced signal (MIS). After the irradiation, different species of free radicals were identified, the so-called radiation induced signal (RIS). (author)

  9. Implementation of Service Differentiation to Achieve Competitive Advantage. Case: Nevsky Hotel Grand.

    OpenAIRE

    Martysevich, Anna

    2013-01-01

    The main purpose of the thesis was to find out which hotel services could bring competitive advantage to the Nevsky Hotel Grand and differentiate the hotel from the competitors. What could be improved in the services of the hotel or which kind of services could be created in the hotel in order to attract more customers and be competitive on the market. The theoretical framework of the thesis was based on the data gathered from various sources of information in printed and electronic form s...

  10. MEG studies prohibited muon decays to explore grand unified theories of elementary particles

    International Nuclear Information System (INIS)

    Mori, Toshinori

    2009-01-01

    The MEG experiment, designed and proposed by Japanese physicists, is being carried out at Paul Scherrer Institute (PSI) in Switzerland, in collaboration with physicists from Italy, Switzerland, Russia and U.S.A. The experiment will make an extensive search for a muon's two-body decay into an electron and a gamma ray, μ→eγ, which is prohibited in the Standard Model of elementary particles, to explore Supersymmetric Grand Unified Theories. This article gives a brief description of the MEG experiment with an emphasis on the innovative experimental techniques developed to achieve the unprecedented experimental sensitivity. (author)

  11. Overcoming challenges

    Medline Plus

    Full Text Available ... breastfeeding Overcoming challenges Common questions about breastfeeding and pain Breastfeeding checklist: How to get a good latch Finding ... myths Overcoming challenges Common questions about breastfeeding and pain Breastfeeding checklist: How to get a good latch Finding ...

  12. Overcoming challenges

    Medline Plus

    Full Text Available ... section Back to section menu It's Only Natural Planning ahead Breastfeeding and baby basics Making breastfeeding work ... It's Only Natural Overcoming challenges It's Only Natural Planning ahead Addressing breastfeeding myths Overcoming challenges Common questions ...

  13. VT Built Up Lands in Grand Isle County - 1986

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  14. VT Built Up Lands in Grand Isle County - 1941

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  15. Constructing 5d orbifold grand unified theories from heterotic strings

    International Nuclear Information System (INIS)

    Kobayashi, Tatsuo; Raby, Stuart; Zhang Renjie

    2004-01-01

    A three-generation Pati-Salam model is constructed by compactifying the heterotic string on a particular T 6 /Z 6 Abelian symmetric orbifold with two discrete Wilson lines. The compactified space is taken to be the Lie algebra lattice G 2 -bar SU(3)-bar SO(4). When one dimension of the SO(4) lattice is large compared to the string scale, this model reproduces many features of a 5d SO(10) grand unified theory compactified on an S 1 /Z 2 orbifold. (Of course, with two large extra dimensions we can obtain a 6d SO(10) grand unified theory.) We identify the orbifold parities and other ingredients of the orbifold grand unified theories in the string model. Our construction provides a UV completion of orbifold grand unified theories, and gives new insights into both field theoretical and string theoretical constructions

  16. 27 CFR 9.119 - Middle Rio Grande Valley.

    Science.gov (United States)

    2010-04-01

    ... Middle Rio Grande Valley. (a) Name. The name of the viticultural area described in this section is... 1979. (24) Veguita, N. Mex. (1952), revised 1979. (25) Wind Mesa, N. Mex. (1952), revised 1967. (c...

  17. A GRAND PLAN FOR EARTH LOVE EDUCATION IN SOUTHERN ...

    African Journals Online (AJOL)

    cognition. From this doubtful synthesis, the researcher appears to have constructed a grand theory of how the world without ... problem here is that all of the students (English. Xhosa and ..... accompanying 'earthy music' will contrihute to.

  18. Casa Grande Ruins National Monument acoustical monitoring 2010

    Science.gov (United States)

    2014-11-01

    During September 2010, The Volpe Center collected baseline acoustical data at Casa Grande National Monument (CAGR), at one site for 28 days. The baseline data collected during this period will help park managers and planners estimate the effects of f...

  19. Flocculent and grand design spiral arm structure in cluster galaxies

    International Nuclear Information System (INIS)

    Elmegreen, D.M.

    1982-01-01

    A total of 829 spiral galaxies in 22 clusters having redshifts between z = 0.02 and 0.06 were classified according to the appearance of their spiral arm structures. The fraction of galaxies that have a grand design spiral structure was found to be higher among barred galaxies than among non-barred galaxies (at z = 0.02, 95 per cent of strongly barred galaxies have a grand design, compared with 67 per cent of non-barred or weakly barred galaxies). Cluster galaxies and distant non-cluster galaxies have the same fraction of grand design galaxies when resolution effects are considered. The grand design fraction among cluster galaxies is also similar to the fraction observed among nearby galaxies in binary systems and in groups. (author)

  20. Albuquerque/Middle Rio Grande Urban Waters Viewer

    Data.gov (United States)

    U.S. Environmental Protection Agency — These data have been compiled in support of the Middle Rio Grande/Albuquerque Urban Waters Partnership for the region including Albuquerque, New Mexico.The Middle...

  1. The challenge of localizing vehicle backup alarms: Effects of passive and electronic hearing protectors, ambient noise level, and backup alarm spectral content

    Directory of Open Access Journals (Sweden)

    Khaled A Alali

    2011-01-01

    Full Text Available A human factors experiment employed a hemi-anechoic sound field in which listeners were required to localize a vehicular backup alarm warning signal (both a standard and a frequency-augmented alarm in 360-degrees azimuth in pink noise of 60 dBA and 90 dBA. Measures of localization performance included: (1 percentage correct localization, (2 percentage of right--left localization errors, (3 percentage of front-rear localization errors, and (4 localization absolute deviation in degrees from the alarm′s actual location. In summary, the data demonstrated that, with some exceptions, normal hearing listeners′ ability to localize the backup alarm in 360-degrees azimuth did not improve when wearing augmented hearing protectors (including dichotic sound transmission earmuffs, flat attenuation earplugs, and level-dependent earplugs as compared to when wearing conventional passive earmuffs or earplugs of the foam or flanged types. Exceptions were that in the 90 dBA pink noise, the flat attenuation earplug yielded significantly better accuracy than the polyurethane foam earplug and both the dichotic and the custom-made diotic electronic sound transmission earmuffs. However, the flat attenuation earplug showed no benefit over the standard pre-molded earplug, the arc earplug, and the passive earmuff. Confusions of front-rear alarm directions were most significant in the 90 dBA noise condition, wherein two types of triple-flanged earplugs exhibited significantly fewer front-rear confusions than either of the electronic muffs. On all measures, the diotic sound transmission earmuff resulted in the poorest localization of any of the protectors due to the fact that its single-microphone design did not enable interaural cues to be heard. Localization was consistently more degraded in the 90 dBA pink noise as compared with the relatively quiet condition of the 60 dBA pink noise. A frequency-augmented backup alarm, which incorporated 400 Hz and 4000 Hz components

  2. Nalisis Kinerja Keuangan pada PT. Grand Victoria Hotel di Samarinda

    OpenAIRE

    -, Atmajaya -

    2013-01-01

    Based on the results of analysis show that the performance of PT. Hotel Grand Victorian is measured using liquidity ratios and profitability ratios decreased from 2010-2012. Performance PT. Grand Victorian is measured using the liquidity ratio has decreased from year 2010-2012 consists of current ratio has decreased, and this is because the total current assets has increased and decreased. Meanwhile, the cash ratio from year 2010-2012 has increased, this is because the total cash and cash equ...

  3. Simulations of Precipitation Variability over the Upper Rio Grande Basin

    International Nuclear Information System (INIS)

    Costigan, Keeley R.; Bossert, James E.; Langley, David L.

    1997-10-01

    In this research, we study Albuquerque's water and how it may be affected by changes in the regional climate, as manifested by variations in Rio Grande water levels. To do this, we rely on the use of coupled atmospheric, runoff, and ground water models. Preliminary work on the project has focused on uncoupled simulations of the aquifer beneath Albuquerque and winter precipitation simulations of the upper Rio Grande Basin. The latter is discussed in this paper

  4. Restrictions on SU(5) as a grand unified theory

    International Nuclear Information System (INIS)

    Shellard, R.C.

    1984-01-01

    Some restrictions imposed upon Grand Unified Theories by dynamical symetry breakdown are examined. They are shown that, in particular, theories SU(5) as symmetry group, with 3 or more fermion families undergo dynamical symmetry breakdown, and some of the fermions will acquire mass at the Grand Unified scale. On the other hand, the SO(10) group, with 3 families is free from this problem. (Author) [pt

  5. Tres grandes plataformas marinas Mar del Norte

    Directory of Open Access Journals (Sweden)

    Soulas, R.

    1978-03-01

    Full Text Available This article analyzes the different building stages of three large sea platforms. After studying the structure's main characteristics, preparing scale models and calculating ail the elements, platform construction was carried out in three stages: — Dry-dock construction of the hull base. — Installation in the water and finishing the structure. — Immersion and bridge installation. Finally, the necessary operations to move the platform to its definite location were carried out. The structures are formed by a parallelepiped hull of reinforced concrete, divided into compartments by means of vertical orthogonals panels on top of which 2 or 4 piles are placed to support the bridge.

    En este artículo se analizan las diversas etapas en la realización de tres grandes plataformas marinas. Después de un estudio de las características principales de la estructura, ensayos en modelo reducido y cálculo de todos los elementos, se procede a la construcción de las plataformas en tres fases: — Construcción en seco de la base del casco. — Colocación en el agua y acabado de la estructura. — Inmersión y colocación del puente. Por último, se realizan las operaciones necesarias para llevar la plataforma a su ubicación definitiva. Las estructuras están formadas por un casco paralelepipédico de hormigón armado, dividido en compartimientos mediante tabiques verticales ortogonales y sobre el que se han colocado 2 ó 4 pilas que soportan el puente.

  6. Electronic Cigarettes for Curbing the Tobacco-Induced Burden of Noncommunicable Diseases: Evidence Revisited with Emphasis on Challenges in Sub-Saharan Africa

    Directory of Open Access Journals (Sweden)

    Jobert Richie N. Nansseu

    2016-01-01

    Full Text Available Introduction. This review examines whether electronic cigarettes (e-cigs implementation or vulgarization in sub-Saharan Africa (SSA could be helpful in curtailing the toll of tobacco smoking in the region. Discussion. There are about 1.3 billion smokers worldwide, with nearly 80% of them living in developing countries where the burden of tobacco-related illnesses and deaths is the heaviest. Studies report that e-cigs may facilitate smoking cessation, reduction, or abstinence and may pose only a small fraction of the risks of traditional tobacco cigarettes; e-cigs may also considerably reduce second-hand smoking. Thereby, implementation of e-cig use could help to substantially reduce the burden driven by tobacco smoking in SSA, in a particular context of lack of regulations and control policies towards this threat. However, the evidence is not clear on whether e-cigs are risk-free, especially if used in the long term. Conclusions. On the whole, if e-cigs were to be introduced in SSA, they should be strictly recommended to current and/or ex-smokers as a method to quit smoking or prevent relapse and never-smokers should be strongly encouraged to avoid using these devices. Bans on sales of e-cigs to youngsters should be legislated, e-cig advertisements prohibited, and their usage continuously controlled and monitored.

  7. Using electronic medical records analysis to investigate the effectiveness of lifestyle programs in real-world primary care is challenging: a case study in diabetes mellitus.

    Science.gov (United States)

    Linmans, Joris J; Viechtbauer, Wolfgang; Koppenaal, Tjarco; Spigt, Mark; Knottnerus, J André

    2012-07-01

    The increasing prevalence of diabetes suggests a gap between real world and controlled trial effectiveness of lifestyle interventions, but real-world investigations are rare. Electronic medical registration facilitates research on real-world effectiveness, although such investigations may require specific methodology and statistics. We investigated the effects of real-world primary care for patients with type 2 diabetes mellitus (T2DM). We used medical records of patients (n=2,549) with T2DM from 10 primary health care centers. A mixed-effects regression model for repeated measurements was used to evaluate the changes in weight and Hemoglobin A1c (HbA1c) over time. There was no statistically significant change in weight (+0.07 kg, P=0.832) and HbA1c (+0.03%, P=0.657) during the observation period of 972 days. Most patients maintained their physical activity level (70%), and 54 % had an insufficient activity level. The variability in the course of weight and HbA1c was because of differences between patients and not between health care providers. Despite effective lifestyle interventions in controlled trial settings, we found that real-world primary care is only able to stabilize weight and HbA1c in patients with T2DM over time. Medical registration can be used to monitor the actual effectiveness of interventions in primary care. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Printed Electronics

    Science.gov (United States)

    Wade, Jessica; Hollis, Joseph Razzell; Wood, Sebastian

    2018-04-01

    The combination of printing technology with manufacturing electronic devices enables a new paradigm of printable electronics, where 'smart' functionality can be readily incorporated into almost any product at low cost. Over recent decades, rapid progress has been made in this field, which is now emerging into the industrial andcommercial realm. However, successful development and commercialisation on a large scale presents some significant technical challenges. For fully-printable electronic systems, all the component parts must be deposited from solutions (inks), requiring the development of new inorganic, organic and hybrid materials.A variety of traditional printing techniques are being explored and adapted forprinting these new materials in ways that result in the best performing electronicdevices. Whilst printed electronics research has initially focused on traditional typesof electronic device such as light-emitting diodes, transistors, and photovoltaics, it is increasingly apparent that a much wider range of applications can be realised. The soft and stretchable nature of printable materials makes them perfect candidates forbioelectronics, resulting in a wealth of research looking at biocompatible printable inks and biosensors. Regardless of application, the properties of printed electronicmaterials depend on the chemical structures, processing conditions, device architecture,and operational conditions, the complex inter-relationships of which aredriving ongoing research. We focus on three particular 'hot topics', where attention is currently focused: novel materials, characterisation techniques, and device stability. With progress advancing very rapidly, printed electronics is expected to grow over the next decade into a key technology with an enormous economic and social impact.

  9. Electronic Effects on Room-Temperature, Gas-Phase C-H Bond Activations by Cluster Oxides and Metal Carbides: The Methane Challenge.

    Science.gov (United States)

    Schwarz, Helmut; Shaik, Sason; Li, Jilai

    2017-12-06

    This Perspective discusses a story of one molecule (methane), a few metal-oxide cationic clusters (MOCCs), dopants, metal-carbide cations, oriented-electric fields (OEFs), and a dizzying mechanistic landscape of methane activation! One mechanism is hydrogen atom transfer (HAT), which occurs whenever the MOCC possesses a localized oxyl radical (M-O • ). Whenever the radical is delocalized, e.g., in [MgO] n •+ the HAT barrier increases due to the penalty of radical localization. Adding a dopant (Ga 2 O 3 ) to [MgO] 2 •+ localizes the radical and HAT transpires. Whenever the radical is located on the metal centers as in [Al 2 O 2 ] •+ the mechanism crosses over to proton-coupled electron transfer (PCET), wherein the positive Al center acts as a Lewis acid that coordinates the methane molecule, while one of the bridging oxygen atoms abstracts a proton, and the negatively charged CH 3 moiety relocates to the metal fragment. We provide a diagnostic plot of barriers vs reactants' distortion energies, which allows the chemist to distinguish HAT from PCET. Thus, doping of [MgO] 2 •+ by Al 2 O 3 enables HAT and PCET to compete. Similarly, [ZnO] •+ activates methane by PCET generating many products. Adding a CH 3 CN ligand to form [(CH 3 CN)ZnO] •+ leads to a single HAT product. The CH 3 CN dipole acts as an OEF that switches off PCET. [MC] + cations (M = Au, Cu) act by different mechanisms, dictated by the M + -C bond covalence. For example, Cu + , which bonds the carbon atom mostly electrostatically, performs coupling of C to methane to yield ethylene, in a single almost barrier-free step, with an unprecedented atomic choreography catalyzed by the OEF of Cu + .

  10. Challenges in risk estimation using routinely collected clinical data: The example of estimating cervical cancer risks from electronic health-records.

    Science.gov (United States)

    Landy, Rebecca; Cheung, Li C; Schiffman, Mark; Gage, Julia C; Hyun, Noorie; Wentzensen, Nicolas; Kinney, Walter K; Castle, Philip E; Fetterman, Barbara; Poitras, Nancy E; Lorey, Thomas; Sasieni, Peter D; Katki, Hormuzd A

    2018-06-01

    Electronic health-records (EHR) are increasingly used by epidemiologists studying disease following surveillance testing to provide evidence for screening intervals and referral guidelines. Although cost-effective, undiagnosed prevalent disease and interval censoring (in which asymptomatic disease is only observed at the time of testing) raise substantial analytic issues when estimating risk that cannot be addressed using Kaplan-Meier methods. Based on our experience analysing EHR from cervical cancer screening, we previously proposed the logistic-Weibull model to address these issues. Here we demonstrate how the choice of statistical method can impact risk estimates. We use observed data on 41,067 women in the cervical cancer screening program at Kaiser Permanente Northern California, 2003-2013, as well as simulations to evaluate the ability of different methods (Kaplan-Meier, Turnbull, Weibull and logistic-Weibull) to accurately estimate risk within a screening program. Cumulative risk estimates from the statistical methods varied considerably, with the largest differences occurring for prevalent disease risk when baseline disease ascertainment was random but incomplete. Kaplan-Meier underestimated risk at earlier times and overestimated risk at later times in the presence of interval censoring or undiagnosed prevalent disease. Turnbull performed well, though was inefficient and not smooth. The logistic-Weibull model performed well, except when event times didn't follow a Weibull distribution. We have demonstrated that methods for right-censored data, such as Kaplan-Meier, result in biased estimates of disease risks when applied to interval-censored data, such as screening programs using EHR data. The logistic-Weibull model is attractive, but the model fit must be checked against Turnbull non-parametric risk estimates. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  11. The challenge of dating Early Pleistocene fossil teeth by the combined uranium series-electron spin resonance method: the Venta Micena palaeontological site (Orce, Spain)

    International Nuclear Information System (INIS)

    Duval, M.; Falgueres, Ch.; Bahain, J.J.; Shao, Q.; Grun, R.; Aubert, M.; Hellstrom, J.; Dolo, J.M.; Agusti, J.; Martinez-Navarro, B.; Palmqvist, P.; Toro-Moyano, I.

    2011-01-01

    The palaeontological site of Venta Micena (Orce, Andalusia, Spain) lies in the eastern sector of the Guadix-Baza basin, one of the best documented areas in Europe for Plio-Pleistocene bio-stratigraphy. The combination of bio-chronological and palaeo-magnetic results, combined with the radiometric data obtained for Atapuerca Sima del Elefante, indicated that the Venta Micena stratum was formed between the Jaramillo and Olduvai palaeo-magnetic events, most likely between 1.22 and 1.77 Ma. Five fossil teeth from two outcrops (sites A and B) were selected to assess the potential of combined uranium series-electron spin resonance (US-ESR) dating of Early Pleistocene sites. Although the US-ESR results of the first outcrop showed a large scatter between the three teeth, the mean age of 1.37 ± 0.24 Ma can be considered a reasonable age estimate for Venta Micena. The mean ESR age of 0.62 ± 0.03 Ma obtained for site B seems to be a severe underestimation when compared with the independent age control. This underestimation is attributed to a relative recent U-mobilization event that led to some U-leaching. The results show that any ESR age calculations of old samples are extremely sensitive to variations in the measured 230 Th/ 234 U ratios in dental tissues. Although the results demonstrate that ESR can in principle be applied to Early Pleistocene sites, they also reveal the complexity of dating such old teeth. It is necessary to continue research in several directions, such as study of the behaviour of ESR signals in old teeth and understanding recent U-mobilization processes, to improve the reliability of the combined US-ESR dating method applied to Early Pleistocene times, a period for which the number of available numerical dating techniques is very limited. (authors)

  12. Publicaciones electrónicas: experiencias y desafíos en Perú Electronic publications: experiences and challenges in Peru

    Directory of Open Access Journals (Sweden)

    Maria Esther Mogollón

    2004-12-01

    Full Text Available La autora explica sus experiencias en las publicaciones electrónicas y publicaciones impresas muy importantes como la emblemática Fempress. Aborda el uso de las Tecnologías de la información y la comunicación (TIC, que han permitido compartir información y contribuido al monitoreo de acciones, propiciando la rendición de cuentas y fortalecimiento de redes de mujeres. Mediante las TICs, las mujeres han promovido alianzas y articulaciones, favoreciendo la estructuración y construcción de propuestas y consensos y relaciones más equitativas y democráticas en el movimiento feminista y de mujeres. Describe que a través de las publicaciones electrónicas, se genera e intercambia información acerca de los problemas que atraviesan las mujeres; mujeres crecen y se fortalecen, y crece de manera exponencial la información generada por ellas. Pero estas redes están integradas también por mujeres pobres, campesinas, indígenas, analfabetas, de otros idiomas o con discapacidad que no pueden acceder a las TICs y hay que buscar las formas de revertir esta situación.The author explains her experiences on the electronic publication field, and in very important printed publications such as the emblematic Fempress. She approaches the use of the Technologies of information and communication (TIC, that have allowed to share information and contributed to the invigoration and monitoring of actions that propitiate the rendering of information and strengthening of women's nets. By using the TICs, women have promoted alliances and articulations, favoring the structuring and construction of proposals, consents and more equal and democratic relationships in the feminist and women movement. The author describes that through the eletronic publications it is generated and exchanged information about the problems that women live; their efforts and advances are exposed, the solidarity is developed, and a great variety of themes is approached. The nets of women

  13. Enterotoxemia em caprinos no Rio Grande do Sul Caprine enterotoxaemia in Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Edson M. Colodel

    2003-12-01

    Full Text Available São descritos surtos de enterotoxemia em caprinos em cinco propriedades no Estado do Rio Grande do Sul. Os animais afetados eram, normalmente, encontrados mortos ou apresentavam evolução aguda de 2 a 3 horas com acentuada depressão, cólicas abdominais e diarréia profusa com fibrina. Em duas propriedades relataram-se casos com a evolução de até 12 horas. Em treze animais necropsiados observaram-se aumento de líquidos nas cavidades abdominal, torácica e pericárdica, congestão e hiperemia da serosa e mucosa do intestino, conteúdo do cólon líquido com fibrina além de hemorragias de serosa e fibrina. Em um animal constatou-se microangiopatia cerebral caracterizada por acúmulo de material homogêneo e eosinofílico no espaço perivascular. No conteúdo intestinal, colônias com bastonetes morfológica e bioquimicamente sugestivos de Clostridium perfringens foram caracterizadas no estudo bacteriológico. A soroneutralização em camundongos com conteúdo intestinal dos animais afetados, revelou a presença da toxina épsilon. Estes achados evidenciam a enterotoxemia como doença de importância para criação de caprinos no Rio Grande do Sul.Five outbreaks of caprine enterotoxaemia in Rio Grande do Sul, Brazil, were studied. The animals were found dead or had a clinical course that usually lasted 2-3 hours. From two farms a clinical manifestation period of 12 hours was reported. Clinical signs were characterized by depression, marked abdominal discomfort, profuse watery diarrhea with fibrin clots, and death. Thirteen necropsies were performed and hydropericardium, hydrothorax and hydroperitoneum were commonly found. The mucosa and serosa of the colon were congested, and its contents was watery with multiple fibrin clots. Serosal hemorrhages and fibrin clots in the gallbladder were also seen. Fibrinous colitis and thyphilitis were the most frequent histological changes. Cerebral microangiopathy was observed in one case, which was

  14. 3D View of Grand Canyon, Arizona

    Science.gov (United States)

    2000-01-01

    The Grand Canyon is one of North America's most spectacular geologic features. Carved primarily by the Colorado River over the past six million years, the canyon sports vertical drops of 5,000 feet and spans a 445-kilometer-long stretch of Arizona desert. The strata along the steep walls of the canyon form a record of geologic time from the Paleozoic Era (250 million years ago) to the Precambrian (1.7 billion years ago).The above view was acquired by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument aboard the Terra spacecraft. Visible and near infrared data were combined to form an image that simulates the natural colors of water and vegetation. Rock colors, however, are not accurate. The image data were combined with elevation data to produce this perspective view, with no vertical exaggeration, looking from above the South Rim up Bright Angel Canyon towards the North Rim. The light lines on the plateau at lower right are the roads around the Canyon View Information Plaza. The Bright Angel Trail, which reaches the Colorado in 11.3 kilometers, can be seen dropping into the canyon over Plateau Point at bottom center. The blue and black areas on the North Rim indicate a forest fire that was smoldering as the data were acquired on May 12, 2000.Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of International Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. Science team leader; Moshe Pniel of JPL is the project manager. ASTER is the only high resolution imaging sensor on Terra. The primary goal of the ASTER mission is to obtain high-resolution image data in 14 channels over the entire land surface, as

  15. The challenge of non-invasive cognitive physiology of the human brain: how to negotiate the irrelevant background noise without spoiling the recorded data through electronic averaging.

    Science.gov (United States)

    Tomberg, C; Desmedt, J E

    1999-07-29

    Brain mechanisms involved in selective attention in humans can be studied by measures of regional blood flow and metabolism (by positron emission tomography) which help identify the various locations with enhanced activities over a period of time of seconds. The physiological measures provided by scalp-recorded brain electrical potentials have a better resolution (milliseconds) and can reveal the actual sequences of distinct neural events and their precise timing. We studied selective attention to sensory inputs from fingers because the brain somatic representations are deployed over the brain convexity under the scalp thereby making it possible to assess distinct stages of cortical processing and representation through their characteristic scalp topographies. In the electrical response to a finger input attended by the subject, the well-known P300 manifests a widespread inhibitory mechanism which is released after a target stimulus has been identified. P300 is preceded by distinct cognitive electrogeneses such as P40, P100 and N140 which can be differentiated from the control (obligatory) profile by superimposition or electronic subtraction. The first cortical response N20 is stable across conditions, suggesting that the first afferent thalamocortical volley is not affected by selective attention. At the next stage of modality-specific cortex in which the sensory features are processed and represented, responses were enhanced (cognitive P40) only a very few milliseconds after arrival of the afferent volley at the cortex, thus documenting a remarkable precocity of attention gain control in the somatic modality. The physiology of selective attention also provides useful cues in relation to non-target inputs which the subject must differentiate in order to perform the task. When having to tell fingers apart, the brain strategy for non-target fingers is not to inhibit or filter them out, but rather to submit their input to several processing operations that are

  16. Extreme environment electronics

    CERN Document Server

    Cressler, John D

    2012-01-01

    Unfriendly to conventional electronic devices, circuits, and systems, extreme environments represent a serious challenge to designers and mission architects. The first truly comprehensive guide to this specialized field, Extreme Environment Electronics explains the essential aspects of designing and using devices, circuits, and electronic systems intended to operate in extreme environments, including across wide temperature ranges and in radiation-intense scenarios such as space. The Definitive Guide to Extreme Environment Electronics Featuring contributions by some of the world's foremost exp

  17. Electronics and electronic systems

    CERN Document Server

    Olsen, George H

    1987-01-01

    Electronics and Electronic Systems explores the significant developments in the field of electronics and electronic devices. This book is organized into three parts encompassing 11 chapters that discuss the fundamental circuit theory and the principles of analog and digital electronics. This book deals first with the passive components of electronic systems, such as resistors, capacitors, and inductors. These topics are followed by a discussion on the analysis of electronic circuits, which involves three ways, namely, the actual circuit, graphical techniques, and rule of thumb. The remaining p

  18. Perfluoroalkyl substances in waters along the Grand Canal, China.

    Science.gov (United States)

    Piao, H T; Jiao, X C; Gai, N; Chen, S; Lu, G H; Yin, X C; Yamazaki, E; Yamashita, N; Tan, K Y; Yang, Y L; Pan, J

    2017-07-01

    The Grand Canal, also known as the Beijing-Hangzhou Grand Canal, is a UNESCO World Heritage Site and the longest canal in the world. It is an important trunk line of the South-to-North Water Diversion Project in China. The contamination status and spatial distributions of perfluoroalky substances (PFASs) in waters of the Grand Canal were investigated. The total concentrations of PFASs (∑PFASs) range from 7.8 ng/L to 218.0 ng/L, with high ∑PFASs occurring in the southern part of the Grand Canal which is located in a highly urbanized and economically developed region. The dominance of PFOA showed a decreasing trend toward north while shorter chain homologue proportions increased in the northern part of the Canal which mainly traverses underdeveloped and rural areas in Eastern China. Positive correlations were observed between ∑PFASs and the population density as well as GDP per capita. Intersection with large rivers may affect the contamination levels and composition of PFASs in the water of the Grand Canal near the intersection sites. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Flocculent and grand design spiral galaxies in groups: time scales for the persistence of grand design spiral structures

    International Nuclear Information System (INIS)

    Elmegreen, B.G.; Elmegreen, D.M.

    1983-01-01

    Spiral arm classifications were made for 261 low-inclination galaxies in groups listed by Huchra and Geller. The fractional occurrence of grand design spiral structure in nonbarred galaxies was found to increase from approx.0.1 to approx.0.6 and then level off as the group crossing rate or galaxy collision rate in a group increases. A simple model is discussed where the random encounters between galaxies of any type and flocculent galaxies induce transient grand design spirals in the flocculent galaxies. If this grand-design stimulation occurs for binary collisions with impact parameters less than αR 25 , were R 25 is the galactic radius at 25 mag arcsec - 2 , and if the induced grand design spirals persist for an average time equal to #betta# galactic rotations, then the quantity α 2 #betta# equals approximately 3 x 10 4 . If binary collisions are responsible for grand design spirals, then this result implies either that the induced spirals last for many galactic rotations (#betta#>15), or that they can be stimulated by very remote encounters (α>45.) Alternatively, grand design spirals may be stimulated by multiple galaxy encounters, which would be the case for such large α, or by interactions with the potential well of the associated group, rather than by simple binary encounters. Weak correlations between the grand design fraction and the galaxy size, or between this fraction and the total number of galaxies in a group, were also found. Spiral structures of barred galaxies show no correlations with group environment

  20. SO(10) - Grand unification and fermion masses

    International Nuclear Information System (INIS)

    Oezer, A.D.

    2005-01-01

    In this work, we study SO(10) grand unification in its full extent by using different explicit matrix representations which exhibit the structure of SO(10) in a very transparent way. Our approach consists mainly of two stages: We derive the explicit expressions of the mass-eigenvalues and mass-eigenstates of the physical gauge bosons from a mass squared-matrix that contains all the information about the mixing parameters among the gauge fields and the phases which are sources for CP violation. In the light of this analysis, we derive the explicit expressions for the interaction Lagrangians of the charged currents, the neutral currents and the charged and colored currents in SO(10). We present explicit expressions of the vector and axial-vector couplings of the two neutral currents in SO(10). We show how the baryon, lepton and baryon minus lepton number violating processes and their explicit CP violating phases are accommodated in the SO(10) theory. The Higgs potential that we use to implement in the Higgs mechanism is constructed in a most general fashion through a careful study of the Higgs fields of SO(10), where we give special emphasis on illustrating the explicit matrix representation of these Higgs fields. The potential part of the Higgs Lagrangian will give us the properties of the minimum of the vacuum, and the kinetic part will give us the mass-squared matrix of the gauge bosons via spontaneous symmetry breakdown. The same Higgs multiplets will be coupled to fermions through a democratic Yukawa matrix. Thereby, we derive explicit expressions for the fermion masses of the third family including Majorana and Dirac masses for neutrinos. We introduce a flavor-eigenbasis for neutrinos and find the mass-eigenstates and mass-eigenvalues of the neutrinos. Explicit expressions for CP violation in the neutrino sector are obtained. In the second stage of our work, we evaluate all the above mentioned quantities. In addition, we present the values of the physical

  1. Uncovering the Transnational Networks, Organisational Techniques and State-Corporate Ties Behind Grand Corruption: Building an Investigative Methodology

    Directory of Open Access Journals (Sweden)

    Kristian Lasslett

    2017-11-01

    Full Text Available While grand corruption is a major global governance challenge, researchers notably lack a systematic methodology for conducting qualitative research into its complex forms. To address this lacuna, the following article sets out and applies the corruption investigative framework (CIF, a methodology designed to generate a systematic, transferable approach for grand corruption research. Its utility will be demonstrated employing a case study that centres on an Australian-led megaproject being built in Papua New Guinea’s capital city, Port Moresby. Unlike conventional analyses of corruption in Papua New Guinea, which emphasise its local characteristics and patrimonial qualities, application of CIF uncovered new empirical layers that centre on transnational state-corporate power, the ambiguity of civil society, and the structural inequalities that marginalise resistance movements. The important theoretical consequences of the findings and underpinning methodology are explored.

  2. Biomechanical analysis technique choreographic movements (for example, "grand battman jete"

    Directory of Open Access Journals (Sweden)

    Batieieva N.P.

    2015-04-01

    Full Text Available Purpose : biomechanical analysis of the execution of choreographic movement "grand battman jete". Material : the study involved students (n = 7 of the department of classical choreography faculty of choreography. Results : biomechanical analysis of choreographic movement "grand battman jete" (classic exercise, obtained kinematic characteristics (path, velocity, acceleration, force of the center of mass (CM bio parts of the body artist (foot, shin, thigh. Built bio kinematic model (phase. The energy characteristics - mechanical work and kinetic energy units legs when performing choreographic movement "grand battman jete". Conclusions : It was found that the ability of an athlete and coach-choreographer analyze the biomechanics of movement has a positive effect on the improvement of choreographic training of qualified athletes in gymnastics (sport, art, figure skating and dance sports.

  3. Liberating methodological thinking in human sciences from grand theories

    DEFF Research Database (Denmark)

    Kharlamov, Nikita; Baldursson, Einar Baldvin

    2016-01-01

    focus on the necessity of a “grand unified theory” at the expense of any and all alternative perspectives. Properties of grand theories are discussed on the examples of Giddens and Bourdieu. It is argued that grand theories hamper a more productive focus on concrete phenomena. Robert Merton’s focus......Many humanistic and social disciplines are naturally inclined to seek for human-, person-, self- centered focus, and develop a holistic theory of such. Such disciplines continually engage with philosophical, metaphysical and meta-theoretical perspectives. This engagement often leads to a singular...... on “middle range” theories is revisited and its continuing relevance is highlighted. The level of abstraction characteristic of such theories, as well as the way they engage with the empirical social reality, are discussed. The article concludes by considering the paradoxical reductionism that can...

  4. Environmental Audit of the Grand Junction Projects Office

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-01

    The Grand Junction Projects Office (GJPO) is located in Mesa County, Colorado, immediately south and west of the Grand Junction city limits. The US Atomic Energy Commission (AEC) established the Colorado Raw Materials Office at the present-day Grand Junction Projects Office in 1947, to aid in the development of a viable domestic uranium industry. Activities at the site included sampling uranium concentrate; pilot-plant milling research, including testing and processing of uranium ores; and operation of a uranium mill pilot plant from 1954 to 1958. The last shipment of uranium concentrate was sent from GJPO in January, 1975. Since that time the site has been utilized to support various DOE programs, such as the former National Uranium Resource Evaluation (NURE) Program, the Uranium Mill Tailings Remedial Action Project (UMTRAP), the Surplus Facilities Management Program (SFMP), and the Technical Measurements Center (TMC). All known contamination at GJPO is believed to be the result of the past uranium milling, analyses, and storage activities. Hazards associated with the wastes impounded at GJPO include surface and ground-water contamination and potential radon and gamma-radiation exposure. This report documents the results of the Baseline Environmental Audit conducted at Grand Junction Projects Office (GJPO) located in Grand Junction, Colorado. The Grand Junction Baseline Environmental Audit was conducted from May 28 to June 12, 1991, by the Office of Environmental Audit (EH-24). This Audit evaluated environmental programs and activities at GJPO, as well as GJPO activities at the State-Owned Temporary Repository. 4 figs., 12 tabs.

  5. Regional economic impacts of Grand Canyon river runners.

    Science.gov (United States)

    Hjerpe, Evan E; Kim, Yeon-Su

    2007-10-01

    Economic impact analysis (EIA) of outdoor recreation can provide critical social information concerning the utilization of natural resources. Outdoor recreation and other non-consumptive uses of resources are viewed as environmentally friendly alternatives to extractive-type industries. While outdoor recreation can be an appropriate use of resources, it generates both beneficial and adverse socioeconomic impacts on rural communities. The authors used EIA to assess the regional economic impacts of rafting in Grand Canyon National Park. The Grand Canyon region of northern Arizona represents a rural US economy that is highly dependent upon tourism and recreational expenditures. The purpose of this research is twofold. The first is to ascertain the previously unknown regional economic impacts of Grand Canyon river runners. The second purpose is to examine attributes of these economic impacts in terms of regional multipliers, leakage, and types of employment created. Most of the literature on economic impacts of outdoor recreation has focused strictly on the positive economic impacts, failing to illuminate the coinciding adverse and constraining economic impacts. Examining the attributes of economic impacts can highlight deficiencies and constraints that limit the economic benefits of recreation and tourism. Regional expenditure information was obtained by surveying non-commercial boaters and commercial outfitters. The authors used IMPLAN input-output modeling to assess direct, indirect, and induced effects of Grand Canyon river runners. Multipliers were calculated for output, employment, and income. Over 22,000 people rafted on the Colorado River through Grand Canyon National Park in 2001, resulting in an estimated $21,100,000 of regional expenditures to the greater Grand Canyon economy. However, over 50% of all rafting-related expenditures were not captured by the regional economy and many of the jobs created by the rafting industry are lower-wage and seasonal. Policy

  6. Environmental Audit of the Grand Junction Projects Office

    International Nuclear Information System (INIS)

    1991-08-01

    The Grand Junction Projects Office (GJPO) is located in Mesa County, Colorado, immediately south and west of the Grand Junction city limits. The US Atomic Energy Commission (AEC) established the Colorado Raw Materials Office at the present-day Grand Junction Projects Office in 1947, to aid in the development of a viable domestic uranium industry. Activities at the site included sampling uranium concentrate; pilot-plant milling research, including testing and processing of uranium ores; and operation of a uranium mill pilot plant from 1954 to 1958. The last shipment of uranium concentrate was sent from GJPO in January, 1975. Since that time the site has been utilized to support various DOE programs, such as the former National Uranium Resource Evaluation (NURE) Program, the Uranium Mill Tailings Remedial Action Project (UMTRAP), the Surplus Facilities Management Program (SFMP), and the Technical Measurements Center (TMC). All known contamination at GJPO is believed to be the result of the past uranium milling, analyses, and storage activities. Hazards associated with the wastes impounded at GJPO include surface and ground-water contamination and potential radon and gamma-radiation exposure. This report documents the results of the Baseline Environmental Audit conducted at Grand Junction Projects Office (GJPO) located in Grand Junction, Colorado. The Grand Junction Baseline Environmental Audit was conducted from May 28 to June 12, 1991, by the Office of Environmental Audit (EH-24). This Audit evaluated environmental programs and activities at GJPO, as well as GJPO activities at the State-Owned Temporary Repository. 4 figs., 12 tabs

  7. Pequena monografia sobre o Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Ana Maria Pinho

    2014-05-01

    Full Text Available Pequena monografia desenvolvida por membros do Colégio Sevigne, que versa sobre diversos assuntos a respeito do Rio Grande do Sul, divididos em histórico, fronteiras, organização política administrativa, características geográficas, formação geomorfológica, economia, aspectos históricos e geográficos da capital do Estado, generalidades étnicas, e sobre o gaúcho em si. Grande quantidade de ilustrações e poemas enriquecem o artigo.

  8. Severe accident sequences simulated at the Grand Gulf Nuclear Station

    International Nuclear Information System (INIS)

    Carbajo, J.J.

    1999-01-01

    Different severe accident sequences employing the MELCOR code, version 1.8.4 QK, have been simulated at the Grand Gulf Nuclear Station (Grand Gulf). The postulated severe accidents simulated are two low-pressure, short-term, station blackouts; two unmitigated small-break (SB) loss-of-coolant accidents (LOCAs) (SBLOCAs); and one unmitigated large LOCA (LLOCA). The purpose of this study was to calculate best-estimate timings of events and source terms for a wide range of severe accidents and to compare the plant response to these accidents

  9. Grand Minima: Is The Sun Going To Sleep?

    Science.gov (United States)

    Mcintosh, S. W.; Leamon, R. J.

    2014-12-01

    We explore recent observational work which indicate that the energetics of the sun's outer atmosphere have been on a steady decline for the past decade and perhaps longer. Futher, we show that new investigations into evolution of the Sun's global magnetic activity appear to demonstrate a path through which the Sun can go into, and exit from, a grand activity minimum without great difficulty while retaining an activity cycle - only losing sunspots. Are we at the begining of a new grand(-ish) minimum? Naturally, only time will tell, but the observational evidence hint that one may not be far off to what impact on the Sun-Earth Connection.

  10. Falares: a oralidade como elemento construtor da grande-reportagem

    OpenAIRE

    Alex Criado

    2006-01-01

    Esta tese discute a incorporação da oralidade de falantes excluídos social e culturalmente na grande-reportagem. O foco desta pesquisa é refletir como a grande-reportagem no Brasil, em sua missão de desvendamento do real, tem lidado com a questão da oralidade. Discute os desafios para a incorporação dos registros orais de pessoas com baixa escolaridade, tendo em vista o preconceito que existe na sociedade em relação aos falantes que se utilizam de modalidades diferentes da língua padrão. Prop...

  11. Mitigation measures for the La Grande 1 hydroelectric development

    International Nuclear Information System (INIS)

    Faucher, O.; Gagnon, R.

    1992-01-01

    Measures to mitigate environmental impacts of the La Grande 1 hydroelectric development are described. An overview is presented of the La Grande 1 project, its surrounding environment, and the principle environmental repercussions of the reservoir, hydrological changes between the dam and river mouth, construction activities and permanent and temporary structures, and presence of workers. Mitigation measures including compensation, corrective measures (deforestation, selective cutting, fish populations, wildlife populations, land rehabilitation, access roads, fisheries, and erosion control), protective measures, enhancement measures, and contract and employment opportunities for the Cree population are described. 10 refs., 2 figs

  12. Guidebook to Rio Grande rift in New Mexico

    Science.gov (United States)

    Hawley, J.W.

    1978-01-01

    Discusses the details of geologic features along the rift zone. Included are short papers on topics relative to the overall region. These papers and the road logs are of special interest to any one pursuing further study of the rift. This book is a comprehensive guide to the middle and late Cenozoic geology of the Rio Grande region of Colorado and New Mexico. Though initially used on field trips for the International Symposium on Tectonics and Magmatism of the Rio Grande rift, the guidebook will be useful to anyone interested in the Cenozoic history of the 600-mi-long area extending from central Colorado to El Paso, Texas.

  13. Overcoming challenges

    Medline Plus

    Full Text Available ... Disease and Stroke HIV and AIDS Mental Health Pain Pregnancy Reproductive Health Sexual Health Sexually Transmitted Infections ... breastfeeding Overcoming challenges Common questions about breastfeeding and pain Breastfeeding checklist: How to get a good latch ...

  14. Overcoming challenges

    Medline Plus

    Full Text Available ... menu It's Only Natural Planning ahead Breastfeeding and baby basics Making breastfeeding work for you Addressing breastfeeding ... in the African-American community Incredible facts about babies, breastmilk, and breastfeeding Overcoming challenges Common questions about ...

  15. Overcoming challenges

    Medline Plus

    Full Text Available ... facts about babies, breastmilk, and breastfeeding Overcoming challenges Common questions about breastfeeding and pain Breastfeeding checklist: How to get a good latch Finding support It takes a village: Building ...

  16. Cognitive Challenges

    Science.gov (United States)

    ... Alliance Our Story Our Vision Our Team Our Leadership Our Results Our Corporate Policies FAQs Careers Contact Us Media Store Privacy Policy Sitemap Learn Engage Donate About TSC Cognitive Challenges Approximately 45% to 60% of individuals with TSC ...

  17. Overcoming challenges

    Medline Plus

    Full Text Available ... breastfeeding means to them. Subscribe To receive Breastfeeding email updates Enter email Submit Overcoming challenges Breastfeeding has a long list ... breastfeeding means to them. Subscribe To receive Breastfeeding email updates Enter email Submit All material contained on ...

  18. Overcoming challenges

    Medline Plus

    Full Text Available ... into your life Breastfeeding in daily life: At home and in public Laws that support breastfeeding 10 ... and jobs View all pages in this section Home It's Only Natural Overcoming challenges It's Only Natural ...

  19. Electron-electron interactions in artificial graphene

    Science.gov (United States)

    Rasanen, Esa

    2013-03-01

    Recent advances in the creation and modulation of graphenelike systems are introducing a science of ``designer Dirac materials.'' In its original definition, artificial graphene is a man-made nanostructure that consists of identical potential wells (quantum dots) arranged in an adjustable honeycomb lattice in the two-dimensional electron gas. As our ability to control the quality of artificial graphene samples improves, so grows the need for an accurate theory of its electronic properties, including the effects of electron-electron interactions. Here we determine those effects on the band structure and on the emergence of Dirac points, and discuss future investigations and challenges in this field.

  20. Space electronics: radiation belts set new challenges

    International Nuclear Information System (INIS)

    Leray, J.L.; Barillot, C.; Boudenot, J.C.

    1999-01-01

    Telecommunications satellites have been in use since 1962 with the first satellite network (constellation) coming into operation in 1966. GPS systems have been available since the mid seventies. Until now, all these systems have avoided orbits which lie within the radiation belts. The latest constellation projects, offering much wider bandwidths, need to use orbits between 1500 and 2000 km, where the proton density is at its highest. The vulnerability of future generations of components can be predicted by extrapolating the behaviour of current devices. Screening is not a viable option due to cost and weight limitations in satellite applications. As a result, satellite and component manufacturers are seeking new methods of hardening components or making them more radiation tolerant in an environment where the radiation levels are ten times those currently experiences. (authors)

  1. Mercury and selenium accumulation in the Colorado River food web, Grand Canyon, USA

    Science.gov (United States)

    Walters, David M.; E.J. Rosi-Marshall,; Kennedy, Theodore A.; W.F. Cross,; C.V. Baxter,

    2015-01-01

    Mercury (Hg) and selenium (Se) biomagnify in aquatic food webs and are toxic to fish and wildlife. The authors measured Hg and Se in organic matter, invertebrates, and fishes in the Colorado River food web at sites spanning 387 river km downstream of Glen Canyon Dam (AZ, USA). Concentrations were relatively high among sites compared with other large rivers (mean wet wt for 6 fishes was 0.17–1.59 μg g–1 Hg and 1.35–2.65 μg g–1 Se), but consistent longitudinal patterns in Hg or Se concentrations relative to the dam were lacking. Mercury increased (slope = 0.147) with δ15N, a metric of trophic position, indicating biomagnification similar to that observed in other freshwater systems. Organisms regularly exceeded exposure risk thresholds for wildlife and humans (6–100% and 56–100% of samples for Hg and Se, respectfully, among risk thresholds). In the Colorado River, Grand Canyon, Hg and Se concentrations pose exposure risks for fish, wildlife, and humans, and the findings of the present study add to a growing body of evidence showing that remote ecosystems are vulnerable to long-range transport and subsequent bioaccumulation of contaminants. Management of exposure risks in Grand Canyon will remain a challenge, as sources and transport mechanisms of Hg and Se extend far beyond park boundaries. Environ Toxicol Chem2015;9999:1–10

  2. La Grande Guerra fra realtà ed illusione: La Grande Illusion e l’immaginario

    Directory of Open Access Journals (Sweden)

    Simone Di Blasi

    2015-12-01

    Full Text Available The aim of this brief essay is to focus on the relation between the meaning of reality and illusion in the movie La Grande Illusion (1937 by Jean Renoir and therefore to find how these ideas of the author may be productive in a thought about the imaginary. After a short look on the movies made at that time on the First World War, there is an overview of the French director poetics, which redefines the conception of the realism, contextualizing its work at the point of convergence of two imaginary “technological lines”, the cinema and the aviation. It follows the analysis of the movie and the illusions, as social largely shared imaginaries, described by the author. In the end it is showed the importance and the of illusion in Renoir’s poetics. Beyond the relationship realityfiction, he thought a dynamic reciprocity among illusion and reality: so that the reality is as “illusion” (a ruled horizon in which it is possible to enjoy a world of play and the illusion as an activity creating contents of “reality”.

  3. FY 1992 Blue Book: Grand Challenges: High Performance Computing and Communications

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — High performance computing and computer communications networks are becoming increasingly important to scientific advancement, economic competition, and national...

  4. The grand challenge of developing in situ observational oceanography in South Africa

    CSIR Research Space (South Africa)

    Roberts, M

    2010-12-01

    Full Text Available , underwater temperature recorders (UTRs), wave buoys, as well as locally developed in situ measurement sensor and platform prototypes (dial-out UTRs, coastal and deep ocean buoys) have been incorporated into a regional in-situ observational network. A modular...

  5. GeoInquiries: Addressing a Grand Challenge for Teaching with GIS in Schools

    Science.gov (United States)

    DiBiase, D.; Baker, T.

    2016-12-01

    According to the National Research Council (2006), geographic information systems (GIS) is a powerful tool for expanding students' abilities to think spatially, a critical skill for future STEM professionals. However, educators in mainstream subjects in U.S. education have struggled for decades to use GIS effectively in classrooms. GeoInquiries are no cost, standards-based (NGSS or AP), Creative Commons-licensed instructional activities that guide inquiry around map-based concepts found in key subjects like Earth and environmental science. Web maps developed for GeoInquiries expand upon printed maps in leading textbooks by taking advantage of 21st GIS capabilities. GeoInquiry collections consist of 15 activities, each chosen to offer a map-based activity every few weeks throughout the school year. GeoInquiries use a common inquiry instructional framework, learned by many educators during their teacher preparation coursework. GeoInquiries are instructionally flexible - acting as much like building blocks for crafting custom activities as finished instructional materials. Over a half million geoinquiries will be accessed in the next twelve months - serving an anticipated 15 million students. After a generation of outreach to the educators, GIS is finally finding its way the mainstream.

  6. The scientific grand challenges of the 21st century for the Crop Science Society of America

    Science.gov (United States)

    Crop science is a highly integrative science field employing expertise from multiple disciplines to broaden our understanding of agronomic, turf, and forage crops. A major goal of crop science is to ensure an adequate and sustainable production of food, feed, fuel, and fiber for our world’s growing ...

  7. 77 FR 51983 - Availability of Department of Energy EV Everywhere Grand Challenge Initial Framing Document and...

    Science.gov (United States)

    2012-08-28

    ... optimal roles for the private sector, government laboratories, and academia in accelerating PEV technology... information? How can information on private sector innovation be captured without compromising competitive... international competitiveness against international cooperation? D. Program Definition and Management. What...

  8. FY 1993 Blue Book: Grand Challenges 1993: High Performance Computing and Communications

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — High performance computing and computer communications networks are becoming increasingly important to scientific advancement, economic competition, and national...

  9. New Capabilities for Hostile Environments on Z Grand Challenge LDRD - Final Status

    Energy Technology Data Exchange (ETDEWEB)

    Cuneo, Michael E. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Griffin, P. J. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Balch, D. K. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Bell, K. S. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Bierner, J. A. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Coverdale, C. A. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Flanagan, T. M. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Hansen, S. B. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Slaboszewicz, V. Harper- [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Jones, B. M. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Lamppa, D. C. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Martin, W. J. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); McKenney, J. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Moore, N. W. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Parma, E. J. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Peebles, H. C. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Rovang, D. C. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Savage, M. E. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Tang, R. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Vesey, R. A. [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2016-10-01

    The purpose of this project was to develop new physical simulation capabilities in order to support the science-based qualification of nonnuclear weapon components in hostile radiation environments. The project contributes directly to the goals of maintaining a safe, secure, and effective US nuclear stockpile, maintaining strategic deterrence at lower nuclear force levels, extending the life of the nuclear deterrent capability, and to be ready for technological surprise.

  10. On the added value of forensic science and grand innovation challenges for the forensic community

    NARCIS (Netherlands)

    van Asten, A.C.

    2014-01-01

    In this paper the insights and results are presented of a long term and ongoing improvement effort within the Netherlands Forensic Institute (NFI) to establish a valuable innovation programme. From the overall perspective of the role and use of forensic science in the criminal justice system, the

  11. Grand Challenges: Science, Engineering, and Societal Advances, Requiring Networking and Information Technology Research and Development

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — ...the U.S. Government makes critical decisions about appropriate investments in IT R and D to help society forward both socially and economically. To inform that...

  12. Grand challenges in understanding the interplay of climate and land changes

    Science.gov (United States)

    Half of the Earth’s land surface has been altered by human activities, creating various consequences on the climate and weather systems at local to global scales, which in turn affects a myriad of land surface processes and our adaptation behaviors. After reviewing the status and major knowledge gap...

  13. Grand Challenge Problem 3: Empowering Science Teachers Using Technology-Enhanced Scaffolding to Improve Inquiry Learning

    NARCIS (Netherlands)

    Pedaste, Margus; Lazonder, Adrianus W.; Raes, Annelies; Wajeman, Claire; Moore, Emily; Girault, Isabelle; Eberle, Julia; Lund, Kristine; Tchounikine, Pierre; Fischer, Frank

    2016-01-01

    Inquiry learning in technology-enhanced learning (TEL) environments has potential to support science learning. The “symbiosis” between teachers and TEL environments is needed and, therefore, virtual assistants should be “taught” based on pedagogical theories. These assistants should be dynamically

  14. Grand challenges in evolutionary and population genetics: The importance of integrating epigenetics, genomics, modeling, and experimentation

    Science.gov (United States)

    Samuel A. Cushman

    2014-01-01

    This is a time of explosive growth in the fields of evolutionary and population genetics, with whole genome sequencing and bioinformatics driving a transformative paradigm shift (Morozova and Marra, 2008). At the same time, advances in epigenetics are thoroughly transforming our understanding of evolutionary processes and their implications for populations, species and...

  15. Preventing Schizophrenia and Severe Mental Illness: A Grand Challenge for Social Work

    Science.gov (United States)

    DeVylder, Jordan E.

    2016-01-01

    Schizophrenia is a leading cause of disability and health expenditure worldwide and is associated with homelessness, substance use, familial and social isolation, unemployment, involvement with the criminal justice system, stigma, and excess mortality. Prevention may be feasible through intervention with help-seeking "clinical high-risk"…

  16. A DHS Skunkworks Project: Defining and Addressing Homeland Security Grand Challenges

    Science.gov (United States)

    2016-12-01

    million and one scotch and wine IOUs to Uncle Jay and Aunt Barb for their warm and endless hospitality. Finally, I would like to express my gratitude to... benefits of participation (e.g., reputation, visibility, opportunity to participate in technology development and accomplish other personal and...designs its future roadmap to achieve a massive transformational purpose (MTP) of bringing about radical breakthroughs for the benefit of humanity.37 An

  17. Evaluation of intergranular cracks on the ring header cross at Grand Gulf Unit No. 1

    International Nuclear Information System (INIS)

    Czajkowski, C.J.

    1987-01-01

    A metallurgical investigation was performed on a sample of cracked ring header cross material from the Grand Gulf Unit No. 1 Nuclear Power Station. The cracks were located in a 6-7 in (15-17.5 cm) width band running circumferentially below the cross to cap weld with a similar band above the cross to discharger pipe weld. The indications were up to 19 mm in length and 6.0 mm in depth. This particular sample was cut from a cross which had not seen actual service but which had been used to qualify the induction heating stress improvement (IHSI) technique for the Grand Gulf units. The base material was SA 182 material manufactured to SA 403-type WP 304 stainless steel. The investigation consisted of visual/dye penetrant examination, chemical analysis, hardness testing, optical microscopy, scanning electron microscopy and energy dispersive spectroscopy. The evaluated cracks were intergranular and initiated on the forging's exterior surface. The grain size of the material was larger than ASTM 00 and no definitive corrosive species were found by Energy Dispersive Spectroscopy (EDS). The cracking is considered to be the result of the forging having been overheated/burned during manufacture. (author)

  18. Monte Carlo calculation of the energy deposited in the KASCADE GRANDE detectors

    International Nuclear Information System (INIS)

    Mihai, Constantin

    2004-01-01

    The energy deposited by protons, electrons and positrons in the KASCADE GRANDE detectors is calculated with a simple and fast Monte Carlo method. The KASCADE GRANDE experiment (Forschungszentrum Karlsruhe, Germany), based on an array of plastic scintillation detectors, has the aim to study the energy spectrum of the primary cosmic rays around and above the 'knee' region of the spectrum. The reconstruction of the primary spectrum is achieved by comparing the data collected by the detectors with simulations of the development of the extensive air shower initiated by the primary particle combined with detailed simulations of the detector response. The simulation of the air shower development is carried out with the CORSIKA Monte Carlo code. The output file produced by CORSIKA is further processed with a program that estimates the energy deposited in the detectors by the particles of the shower. The standard method to calculate the energy deposit in the detectors is based on the Geant package from the CERN library. A new method that calculates the energy deposit by fitting the Geant based distributions with simpler functions is proposed in this work. In comparison with the method based on the Geant package this method is substantially faster. The time saving is important because the number of particles involved is large. (author)

  19. Carbonaceous aerosol particles from common vegetation in the Grand Canyon

    International Nuclear Information System (INIS)

    Hallock, K.A.; Mazurek, M.A.; Cass, G.R.

    1992-05-01

    The problem of visibility reduction in the Grand Canyon due to fine organic aerosol particles in the atmosphere has become an area of increased environmental concern. Aerosol particles can be derived from many emission sources. In this report, we focus on identifying organic aerosols derived from common vegetation in the Grand Canyon. These aerosols are expected to be significant contributors to the total atmospheric organic aerosol content. Aerosol samples from living vegetation were collected by resuspension of surface wax and resin components liberated from the leaves of vegetation common to areas of the Grand Canyon. The samples were analyzed using high-resolution gas chromatography/mass spectrometry (GC/MS). Probable identification of compounds was made by comparison of sample spectra with National Institute of Standards and Technology (NIST) mass spectral references and positive identification of compounds was made when possible by comparison with authentic standards as well as NIST references. Using these references, we have been able to positively identify the presence of n-alkane and n-alkanoic acid homolog series in the surface waxes of the vegetation sampled. Several monoterpenes, sesquiterpenes, and diterpenes were identified also as possible biogenic aerosols which may contribute to the total organic aerosol abundance leading to visibility reduction in the Grand Canyon

  20. Society and Health in the Lower Rio Grande Valley.

    Science.gov (United States)

    Madsen, William

    Shedding light on problems of mental health and illness that have baffled public health workers attempting to improve the health and welfare of Mexican Americans living in the lower Rio Grande Valley, this document reports the folk customs, social organization, medical practices, and beliefs of the Mexican American of this area. Chapters describe…

  1. Grand Manner Aesthetics in Landscape: From Canvas to Celluloid

    Science.gov (United States)

    Auger, Emily E.

    2009-01-01

    The methods by which environmental issues are aestheticized in late-twentieth-century film is directly and historically related to those established for grand manner painters by Nicholas Poussin (1594-1665) and taught at the French academy from the seventeenth through the nineteenth centuries. That these fundamentals were part of the training of…

  2. Os grandes consumidores de consultas medicas: um estudo de familia

    Directory of Open Access Journals (Sweden)

    M. Pereira Graça

    2002-01-01

    Full Text Available Este artículo describe un estudio sobre algunas características familiares de sujetos grandes consumidores de servicios de salud. Por un lado, se compara un grupo de grandes consumidores de servicios de salud, a nivel de número de consultas, con un grupo control en términos de funcionamiento familiar y actitudes hacia los médicos y la Medicina; por otro lado, se estudia la relación entre la dinámica familiar y las actitudes hacia la Medicina y los médicos en el grupo de los grandes consumidores. Los resultados muestran que los dos grupos de usuarios son significativamente diferentes; además, en el grupo de grandes consumidores el funcionamiento familiar problemático parece ser un factor intermediario en el desarrollo de actitudes menos negativas hacia los médicos y la Medicina. Se discuten las implicaciones que los resultados tienen a nivel de intervención terapéutica.

  3. Eesti nukufilm sai järjekordse grand prix

    Index Scriptorium Estoniae

    2005-01-01

    XII Rahvusvaheline animafilmifestival "KROK-2005", mis toimus laeval, mis sõitis Kiievist Odessasse. Rao Heidmets ja Hardi Volmer said festivali karnevalil oma jänese kostüümi eest grand prix. Eesti filmidest olid programmis "Karl ja Marilyn", "Frank ja Wendy", "Barbarid", "Laud" ja "Conkistadoor"

  4. Piccolo tõi Soomest taas grand prix'

    Index Scriptorium Estoniae

    2009-01-01

    Tänavuse Lappeenrantas toimunud rahvusvahelise suupillifestivali võistumängimisel osalesid suupilliklubi Piccolo orkester, kvartett ja noored solistid. Grand prix' ehk suure võidukarika pälvis Piccolo suupillikvartett koosseisus Ilmar Tõnisson, Andrus Haugas, Andres Kokk ja Elmar Trink. Noorte kategooria võitjaks tunnistati Martin Merevits, kolmandad kohad saavutasid Janek Sildvee bluusi- ja Eduard Einmann diatoonilise suupilli kategoorias

  5. Cosmological origin of the grand-unification mass scale

    International Nuclear Information System (INIS)

    Brout, R.; Englert, F.; Spindel, P.

    1979-01-01

    The origin of the universe as a quantum phenomenon leads to a self-consistently generated space-time structure in which the mass of the created particles is O (kappa/sup -1/2/). We interpret the origin of the universe as a phase transition in which the grand unified symmetry is spontaneously broken

  6. Nuove prospettive storiografiche sulla Grande guerra: violenze, traumi, esperienze

    Directory of Open Access Journals (Sweden)

    Marco Bizzocchi

    2014-03-01

    Full Text Available Il testo propone, attraverso l’analisi delle recensioni pubblicate sulla rivista internazionale “First World War Studies”, una rassegna su alcuni recenti studi storici sulla Prima guerra mondiale. Dopo la svolta degli anni Settanta-Ottanta, la storiografia sta continuando ad approfondire in particolare il tema dei risvolti sociali e culturali della Grande guerra.

  7. France's grandes écoles accused of elitism

    Science.gov (United States)

    Hellemans, Alexander

    2010-02-01

    Physicists in France have backed government plans to open up the country's elite grandes écoles to more students from poorer backgrounds. The government wants to allow up to 30% of students to be given free scholarships in an attempt to broaden the social mix of the student body. The physicists say this would not lead to a lowering of standards.

  8. Construction of calibration pads facility, Walker Field, Grand Junction, Colorado

    International Nuclear Information System (INIS)

    Ward, D.L.

    1978-08-01

    A gamma-ray spectrometer facility was completed at Walker Field Airport, Grand Junction, Colorado, in November 1976. This report describes spectrometers and their calibration, the construction of the spectrometer facility, the radioelement concentrations, procedures for using the facilites, and environmental considerations

  9. Cyber Resilience in de Bestuurskamer : The Grand Conference in Amsterdam

    NARCIS (Netherlands)

    Klaver, M.H.A.

    2013-01-01

    Op 16 oktober 2012 vond in Amsterdam The Grand Conference plaats. Deze conferentie werd georganiseerd door het Centre for the Protection of National lnfrastructure (CPNI.NL) in nauwe samenwerking met de Europese Commissie, de Europese Networkand Information Security Agency (ENISA), het Amerikaanse

  10. Winning in straight sets helps in Grand Slam tennis

    NARCIS (Netherlands)

    Goossens, Dries R.; Kempeneers, Jurgen; Koning, Ruud H.; Spieksma, Frits C. R.

    2015-01-01

    In this contribution, we study whether fatigue resulting from the previous match affects a player's chances of winning his (or her) next match in Grand Slum tennis. We measure relative fatigue levels of two opponents by looking at the difference in number of sets played in their previous match. We

  11. Masses of particles in the SO(18) grand unified model

    International Nuclear Information System (INIS)

    Asatryan, G.M.

    1984-01-01

    The grand unified model based on the orthogonal group SO(18) is treated. The model involves four familiar and four mirror families of fermions. Arising of masses of familiar and mirror particles is studied. The mass of the right-handed Wsub(R) boson interacting via right-handed current way is estimated

  12. A grand-canonical ensemble of randomly triangulated surfaces

    International Nuclear Information System (INIS)

    Jurkiewicz, J.; Krzywicki, A.; Petersson, B.

    1986-01-01

    An algorithm is presented generating the grand-canonical ensemble of discrete, randomly triangulated Polyakov surfaces. The algorithm is used to calculate the susceptibility exponent, which controls the existence of the continuum limit of the considered model, for the dimensionality of the embedding space ranging from 0 to 20. (orig.)

  13. Flood disaster preparedness: a retrospect from Grand Forks, North Dakota.

    Science.gov (United States)

    Siders, C; Jacobson, R

    1998-01-01

    Natural disasters often come without warning. The clinical, financial, and business risks can be enormous. Grand Forks' (ND) healthcare systems experienced a flooding disaster of unprecedented proportions in April of 1997. Planned and practiced disaster and evacuation procedures can significantly reduce a healthcare facilities' risk to life, health, and safety. This article retrospectively analyzes disaster preparation and the complete evacuation of the facilities' patients.

  14. Dynkin weights and global supersymmetry in grand unification

    International Nuclear Information System (INIS)

    Frampton, P.H.; Kephart, T.W.

    1982-01-01

    The requirement that supersymmetry be unbroken in a supersymmetrized gauge theory is shown to imply vanishing Dynkin weight of the components of the Higgs field representation receiving vacuum expectation values. As a corollary a compact expression is obtained for the Dynkin weights of general SU(N) representations. Examples are given for supersymmetrized grand unified theories

  15. The canonical and grand canonical models for nuclear ...

    Indian Academy of Sciences (India)

    Many observables seen in intermediate energy heavy-ion collisions can be explained on the basis of statistical equilibrium. Calculations based on statistical equilibrium can be implemented in microcanonical ensemble, canonical ensemble or grand canonical ensemble. This paper deals with calculations with canonical ...

  16. Interplay between grand unification and supersymmetry in SU(5 ...

    Indian Academy of Sciences (India)

    energy MSSM. break the rank, Aulakh and his collaborators [10–12] have showed that R-parity is exact all the way down to low energies. In this case, grand unification tells us something about supersymmetry and even dark matter. In this article ...

  17. Grande Ronde Basin Fish Habitat Enhancement Project : 1998 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, Vance R.; Powell, Russ M.

    1999-05-01

    The primary goal of ''The Grande Ronde Basin Fish Habitat Improvement Project'' is to access, create, improve, protect, and restore reparian and instream habitat for anadromous salmonids, thereby maximizing opportunities for natural fish production within the basin.

  18. Challenges at the Frontiers of Matter and Energy: Transformative Opportunities for Discovery Science

    Energy Technology Data Exchange (ETDEWEB)

    Hemminger, John C. [Univ. of California, Irvine, CA (United States); Sarrao, John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Crabtree, George [Argonne National Lab. (ANL), Argonne, IL (United States); University of Illinois, Chicago; Flemming, Graham [Univ. of California, Berkeley, CA (United States); Ratner, Mark [Northwestern Univ., Evanston, IL (United States)

    2015-11-01

    inverse design approach, through the harmonious convergence of theoretical, mathematical, computational, and experimental capabilities, could usher in a virtual cornucopia of new materials with functionalities far beyond what nature can provide. Similarly, enhanced mathematical and computational capabilities significantly enhance our ability to extract physical and chemical insights from vastly larger data streams gathered during multimodal and multidimensional experiments using advanced characterization facilities. Exploiting Transformative Advances in Imaging Capabilities across Multiple Scales Historically, improvements in imaging capabilities have always resulted in improved understanding of scientific phenomena. A prime challenge today is finding ways to reconstruct raw data, obtained by probing and mapping matter across multiple scales, into analyzable images. BES investments in new and improved imaging facilities, most notably synchrotron x-ray sources, free-electron lasers, electron microscopes, and neutron sources, have greatly advanced our powers of observation, as have substantial improvements in laboratory- scale technologies. Furthermore, BES is now planning or actively discussing exciting new capabilities. Taken together, these advances in imaging capabilities provide an opportunity to expand our ability to observe and study matter from the 3D spatial perspectives of today to true “4D” spatially and temporally resolved maps of dynamics that allow quantitative predictions of time-dependent material properties and chemical processes. The knowledge gained will impact data storage, catalyst design, drug delivery, structural materials, and medical implants, to name just a few key technologies. ENABLING SUCCESS Seizing each of these five Transformative Opportunities, as well as accelerating further progress on Grand Challenge research, will require specific, targeted investments from BES in the areas of synthesis, meaning the ability to make the materials and

  19. Capital Humano e Desenvolvimento Econômico no Rio Grande do Sul: Uma Abordagem Multivariada

    Directory of Open Access Journals (Sweden)

    Nilson Luiz Costa

    2017-01-01

    Full Text Available This article proposes an analysis from the theories linking human capital to economic development process. The method used consists of multivariate statistical techniques, particularly the Exploratory Factor Analysis and Conglomerates Analysis. Statistics were selected from 496 municipalities in the state of Rio Grande do Sul/Brazil according to their capacity to represents the dynamics of income concentration, quality of education and health, poverty, education and formal work. Among the results, there is a positive and direct association between levels of formal education and economic development, which validates the theoretical contributions of Theodore William Schultz and other authors that stem from their lineage. The results point to the importance of breaking the current paradigms and think education policy beyond the rhetoric of official speeches and overcome the current challenges.

  20. Capital Humano e Desenvolvimento Econômico no Rio Grande do Sul. Uma Abordagem Multivariada

    Directory of Open Access Journals (Sweden)

    Nilson Luiz Costa

    2017-01-01

    Full Text Available This article proposes an analysis from the theories linking human capital to economic development process. The method used consists of multivariate statistical techniques, particularly the Exploratory Factor Analysis and Conglomerates Analysis. Statistics were selected from 496 municipalities in the state of Rio Grande do Sul/Brazil according to their capacity to represents the dynamics of income concentration, quality of education and health, poverty, education and formal work. Among the results, there is a positive and direct association between levels of formal education and economic develop- ment, which validates the theoretical contributions of Theodore William Schultz and other authors that stem from their lineage. The results point to the importance of breaking the current paradigms and think education policy beyond the rhetoric of official speeches and overcome the current challenges.