WorldWideScience

Sample records for gradually increased reaching

  1. Enhanced monoclonal antibody production by gradual increase of osmotic pressure

    OpenAIRE

    Lin, Jianqiang; Takagi, Mutsumi; Qu, Yinbo; Gao, Peiji; Yoshida, Toshiomi

    1999-01-01

    The time length required for the adaptation of AFP-27 hybridoma cells to high osmotic pressure and the effect of a gradual increase of osmotic pressure on monoclonal antibody production were investigated. When the cells were subjected to an increase of osmotic pressure from 300 mOsmol kg-1 to 366 mOsmol kg- 1, the intracellular content of osmoprotective free amino acids reached a maximum level 6 h after the osmotic pressure was increased to 366 mOsmol kg-1. The same time period of 6 h incubat...

  2. Abrupt or gradual increases in photoperiod for broiler breeders ...

    African Journals Online (AJOL)

    There were no significant differences between the two lighting groups for age at sexual maturity, total egg production, egg mass output, mean egg weight to or body weight at 60 weeks. However, the birds given a single abrupt increment had a higher peak rate of lay whilst those given a gradual increase in daylength had ...

  3. Climatic response to a gradual increase of atmospheric carbon dioxide

    International Nuclear Information System (INIS)

    Stouffer, R.J.; Manabe, S.; Bryan, K.

    1990-01-01

    The transient response of a coupled ocean-atmosphere model to an increase of carbon dioxide has been the subject of several studies. The models used in these studies explicitly incorporate the effect of heat transport by ocean currents and are different from the model used by Hansen et al. Here the authors evaluate the climatic influence of increasing atmospheric carbon dioxide using a coupled model recently developed at the NOAA Geophysical Fluid Dynamics Laboratory. The model response exhibits a marked and unexpected interhemispheric asymmetry. In the circumpolar ocean of the southern hemisphere, a region of deep vertical mixing, the increase of surface air temperature is very slow. In the Northern hemisphere of the model, the rise of surface air temperature is faster and increases with latitude, with the exception of the northern North Atlantic, where it is relatively slow because of the weakening of the thermohaline circulation

  4. Responses of respiration and photosynthesis of Scenedesmus protuberans Fritsch to gradual and steep salinity increases

    NARCIS (Netherlands)

    Flameling, I.A.; Kromkamp, J.C.

    1994-01-01

    The effect of an increase in salinity on the physiology of the halotolerant chlorophyte Scenedesmus protuberans was studied in light-limited continuous cultures. It was observed that a gradual, as well as a steep increase in salinity resulted in lower biomass. However, the mechanisms by which this

  5. Modeling Effectiveness of Gradual Increases in Source Level to Mitigate Effects of Sonar on Marine Mammals

    NARCIS (Netherlands)

    Benda-Beckmann, A.M. von; Wensveen, P.J.; Kvadsheim, P.H.; Lam, F.P.A.; Miller, P.J.O.; Tyack, P.L.; Ainslie, M.A.

    2013-01-01

    Ramp-up or soft-start procedures (i.e., gradual increase in the source level) are used to mitigate the effect of sonar sound on marine mammals, although no one to date has tested whether ramp-up procedures are effective at reducing the effect of sound on marine mammals. We investigated the

  6. Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression

    Directory of Open Access Journals (Sweden)

    Jing Sun

    2014-01-01

    Full Text Available Physical training is necessary for effective rehabilitation in the early poststroke period. Animal studies commonly use fixed training intensity throughout rehabilitation and without adapting it to the animals' recovered motor ability. This study investigated the correlation between training intensity and rehabilitation efficacy by using a focal ischemic stroke rat model. Eighty male Sprague-Dawley rats were induced with middle cerebral artery occlusion/reperfusion surgery. Sixty rats with successful stroke were then randomly assigned into four groups: control (CG, n=15, low intensity (LG, n=15, gradually increased intensity (GIG, n=15, and high intensity (HG, n=15. Behavioral tests were conducted daily to evaluate motor function recovery. Stress level and neural recovery were evaluated via plasma corticosterone and brain-derived neurotrophic factor (BDNF concentration, respectively. GIG rats significantly (P<0.05 recovered motor function and produced higher hippocampal BDNF (112.87 ± 25.18 ng/g. GIG and LG rats exhibited similar stress levels (540.63 ± 117.40 nM/L and 508.07 ± 161.30 nM/L, resp., which were significantly lower (P<0.05 than that (716.90 ± 156.48 nM/L of HG rats. Training with gradually increased intensity achieved better recovery with lower stress. Our observations indicate that a training protocol that includes gradually increasing training intensity should be considered in both animal and clinical studies for better stroke recovery.

  7. Gradually Increased Oxygen Administration Improved Oxygenation and Mitigated Oxidative Stress after Resuscitation from Severe Hemorrhagic Shock.

    Science.gov (United States)

    Luo, Xin; Yin, Yujing; You, Guoxing; Chen, Gan; Wang, Ying; Zhao, Jingxiang; Wang, Bo; Zhao, Lian; Zhou, Hong

    2015-11-01

    The optimal oxygen administration strategy during resuscitation from hemorrhagic shock (HS) is still controversial. Improving oxygenation and mitigating oxidative stress simultaneously seem to be contradictory goals. To maximize oxygen delivery while minimizing oxidative damage, the authors proposed the notion of gradually increased oxygen administration (GIOA), which entails making the arterial blood hypoxemic early in resuscitation and subsequently gradually increasing to hyperoxic, and compared its effects with normoxic resuscitation, hyperoxic resuscitation, and hypoxemic resuscitation in severe HS. Rats were subjected to HS, and on resuscitation, the rats were randomly assigned to four groups (n = 8): the normoxic, the hyperoxic, the hypoxemic, and the GIOA groups. Rats were observed for an additional 1 h. Hemodynamics, acid-base status, oxygenation, and oxidative injury were observed and evaluated. Central venous oxygen saturation promptly recovered only in the hyperoxic and the GIOA groups, and the liver tissue partial pressure of oxygen was highest in the GIOA group after resuscitation. Oxidative stress in GIOA group was significantly reduced compared with the hyperoxic group as indicated by the reduced malondialdehyde content, increased catalase activity, and the lower histologic injury scores in the liver. In addition, the tumor necrosis factor-α and interleukin-6 expressions in the liver were markedly decreased in the GIOA group than in the hyperoxic and normoxic groups as shown by the immunohistochemical staining. GIOA improved systemic/tissue oxygenation and mitigated oxidative stress simultaneously after resuscitation from severe HS. GIOA may be a promising strategy to improve resuscitation from HS and deserves further investigation.

  8. Gradually increasing ethinyl estradiol for Turner syndrome may produce good final height but not ideal BMD.

    Science.gov (United States)

    Hasegawa, Yukihiro; Ariyasu, Daisuke; Izawa, Masako; Igaki-Miyamoto, Junko; Fukuma, Mami; Hatano, Megumi; Yagi, Hiroko; Goto, Masahiro

    2017-02-27

    Estrogen replacement therapy in Turner syndrome should theoretically mimic the physiology of healthy girls. The objective of this study was to describe final height and bone mineral density (BMD) in a group of 17 Turner syndrome patients (group E) who started their ethinyl estradiol therapy with an ultra-low dosage (1-5 ng/kg/day) from 9.8-13.7 years. The subjects in group E had been treated with GH 0.35 mg/kg/week since the average age of 7.4 years. The 30 subjects in group L, one of the historical groups, were given comparable doses of GH, and conjugated estrogen 0.3125 mg/week ∼0.3125 mg/day was initiated at 12.2-18.7 years. The subjects in group S, the other historical group, were 21 patients who experienced breast development and menarche spontaneously. Final height (height gain Turner syndrome. The final height in group L was 148.5 ± 3.0 cm with a SD of 1.30 ± 0.55, which was significantly different from the values for group E. The volumetric BMD of group S (0.290 ± 0.026 g/cm 3 ) was significantly different from that of group L or E (0.262 or 0.262 g/cm 3 as a mean, respectively). This is the first study of patients with Turner syndrome where estrogen was administered initially in an ultra-low dose and then increased gradually. Our estrogen therapy in group E produced good final height but not ideal BMD.

  9. Response of ocean acidification to a gradual increase and decrease of atmospheric CO2

    International Nuclear Information System (INIS)

    Cao, Long; Zhang, Han; Zheng, Meidi; Wang, Shuangjing

    2014-01-01

    We perform coupled climate–carbon cycle model simulations to examine changes in ocean acidity in response to idealized change of atmospheric CO 2 . Atmospheric CO 2 increases at a rate of 1% per year to four times its pre-industrial level of 280 ppm and then decreases at the same rate to the pre-industrial level. Our simulations show that changes in surface ocean chemistry largely follow changes in atmospheric CO 2 . However, changes in deep ocean chemistry in general lag behind the change in atmospheric CO 2 because of the long time scale associated with the penetration of excess CO 2 into the deep ocean. In our simulations with the effect of climate change, when atmospheric CO 2 reaches four times its pre-industrial level, global mean aragonite saturation horizon (ASH) shoals from the pre-industrial value of 1288 to 143 m. When atmospheric CO 2 returns from the peak value of 1120 ppm to pre-industrial level, ASH is 630 m, which is approximately the value of ASH when atmospheric CO 2 first increases to 719 ppm. At pre-industrial CO 2 9% deep-sea cold-water corals are surrounded by seawater that is undersaturated with aragonite. When atmospheric CO 2 reaches 1120 ppm, 73% cold-water coral locations are surrounded by seawater with aragonite undersaturation, and when atmospheric CO 2 returns to the pre-industrial level, 18% cold-water coral locations are surrounded by seawater with aragonite undersaturation. Our analysis indicates the difficulty for some marine ecosystems to recover to their natural chemical habitats even if atmospheric CO 2 content can be lowered in the future. (paper)

  10. OPTIMAL practice conditions enhance the benefits of gradually increasing error opportunities on retention of a stepping sequence task.

    Science.gov (United States)

    Levac, Danielle; Driscoll, Kate; Galvez, Jessica; Mercado, Kathleen; O'Neil, Lindsey

    2017-12-01

    Physical therapists should implement practice conditions that promote motor skill learning after neurological injury. Errorful and errorless practice conditions are effective for different populations and tasks. Errorful learning provides opportunities for learners to make task-relevant choices. Enhancing learner autonomy through choice opportunities is a key component of the Optimizing Performance through Intrinsic Motivation and Attention for Learning (OPTIMAL) theory of motor learning. The objective of this study was to evaluate the interaction between error opportunity frequency and OPTIMAL (autonomy-supportive) practice conditions during stepping sequence acquisition in a virtual environment. Forty healthy young adults were randomized to autonomy-supportive or autonomy-controlling practice conditions, which differed in instructional language, focus of attention (external vs internal) and positive versus negative nature of verbal and visual feedback. All participants practiced 40 trials of 4, six-step stepping sequences in a random order. Each of the 4 sequences offered different amounts of choice opportunities about the next step via visual cue presentation (4 choices; 1 choice; gradually increasing [1-2-3-4] choices, and gradually decreasing [4-3-2-1] choices). Motivation and engagement were measured by the Intrinsic Motivation Inventory (IMI) and the User Engagement Scale (UES). Participants returned 1-3 days later for retention tests, where learning was measured by time to complete each sequence. No choice cues were offered on retention. Participants in the autonomy-supportive group outperformed the autonomy-controlling group at retention on all sequences (mean difference 2.88s, p errorful (4 choice) sequence (p error opportunities over time, suggest that participants relied on implicit learning strategies for this full body task and that feedback about successes minimized errors and reduced their potential information-processing benefits. Subsequent

  11. Increasing the reach of forensic genetics with massively parallel sequencing.

    Science.gov (United States)

    Budowle, Bruce; Schmedes, Sarah E; Wendt, Frank R

    2017-09-01

    The field of forensic genetics has made great strides in the analysis of biological evidence related to criminal and civil matters. More so, the discipline has set a standard of performance and quality in the forensic sciences. The advent of massively parallel sequencing will allow the field to expand its capabilities substantially. This review describes the salient features of massively parallel sequencing and how it can impact forensic genetics. The features of this technology offer increased number and types of genetic markers that can be analyzed, higher throughput of samples, and the capability of targeting different organisms, all by one unifying methodology. While there are many applications, three are described where massively parallel sequencing will have immediate impact: molecular autopsy, microbial forensics and differentiation of monozygotic twins. The intent of this review is to expose the forensic science community to the potential enhancements that have or are soon to arrive and demonstrate the continued expansion the field of forensic genetics and its service in the investigation of legal matters.

  12. Plasma leptin and growth hormone levels in the fine flounder (Paralichthys adspersus) increase gradually during fasting and decline rapidly after refeeding.

    Science.gov (United States)

    Fuentes, Eduardo N; Kling, Peter; Einarsdottir, Ingibjörg Eir; Alvarez, Marco; Valdés, Juan Antonio; Molina, Alfredo; Björnsson, Björn Thrandur

    2012-05-15

    In fish, recent studies have indicated an anorexigenic role of leptin and thus its possible involvement in regulation of energy balance and growth. In the present study, the effects of fasting and refeeding periods on plasma leptin levels were studied in the fine flounder, a flatfish with remarkably slow growth. To further assess the endocrine status of the fish during periods of catabolism and anabolism, plasma growth hormone (GH) levels were also analyzed. Under normal feeding condition, plasma leptin and GH levels remained stable and relatively high in comparison with other teleost species. For the three separate groups of fish, fasted for 2, 3, and 4 weeks, respectively, plasma leptin levels increase gradually, becoming significantly elevated after 3 weeks, and reaching highest levels after 4-week fasting. Plasma GH levels were significantly elevated after 2-week fasting. At the onset of refeeding, following a single meal, leptin levels decline rapidly to lower than initial levels within 2 h, irrespective of the length of fasting. Plasma GH also decline, the decrease being significant after 4, 24 and 2 h for the 2, 3 and 4-week fasted groups, respectively. This study shows that plasma leptin levels in the fine flounder are strongly linked to nutritional status and suggests that leptin secretion is regulated by fast-acting mechanisms. Elevated leptin levels in fasted fish may contribute to a passive survival strategy of species which experience natural food shortage periods by lowering appetite and limiting physical foraging activity. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. Effects of a gradually increased load of fish waste silage in co-digestion with cow manure on methane production

    International Nuclear Information System (INIS)

    Solli, Linn; Bergersen, Ove; Sørheim, Roald; Briseid, Tormod

    2014-01-01

    Highlights: • New results from continuous anaerobic co-digestion of fish waste silage (FWS) and cow manure (CM). • Co-digestion of FWS and CM has a high biogas potential. • Optimal mixing ratio of FWS/CM is 13–16/87–84 volume%. • High input of FWS leads to accumulation of NH4+ and VFAs and process failure. - Abstract: This study examined the effects of an increased load of nitrogen-rich organic material on anaerobic digestion and methane production. Co-digestion of fish waste silage (FWS) and cow manure (CM) was studied in two parallel laboratory-scale (8 L effective volume) semi-continuous stirred tank reactors (designated R1 and R2). A reactor fed with CM only (R0) was used as control. The reactors were operated in the mesophilic range (37 °C) with a hydraulic retention time of 30 days, and the entire experiment lasted for 450 days. The rate of organic loading was raised by increasing the content of FWS in the feed stock. During the experiment, the amount (volume%) of FWS was increased stepwise in the following order: 3% – 6% – 13% – 16%, and 19%. Measurements of methane production, and analysis of volatile fatty acids, ammonium and pH in the effluents were carried out. The highest methane production from co-digestion of FWS and CM was 0.400 L CH4 gVS −1 , obtained during the period with loading of 16% FWS in R2. Compared to anaerobic digestion of CM only, the methane production was increased by 100% at most, when FWS was added to the feed stock. The biogas processes failed in R1 and R2 during the periods, with loadings of 16% and 19% FWS, respectively. In both reactors, the biogas processes failed due to overloading and accumulation of ammonia and volatile fatty acids

  14. Effects of a gradually increased load of fish waste silage in co-digestion with cow manure on methane production

    Energy Technology Data Exchange (ETDEWEB)

    Solli, Linn, E-mail: linn.solli@bioforsk.no; Bergersen, Ove; Sørheim, Roald; Briseid, Tormod

    2014-08-15

    Highlights: • New results from continuous anaerobic co-digestion of fish waste silage (FWS) and cow manure (CM). • Co-digestion of FWS and CM has a high biogas potential. • Optimal mixing ratio of FWS/CM is 13–16/87–84 volume%. • High input of FWS leads to accumulation of NH4+ and VFAs and process failure. - Abstract: This study examined the effects of an increased load of nitrogen-rich organic material on anaerobic digestion and methane production. Co-digestion of fish waste silage (FWS) and cow manure (CM) was studied in two parallel laboratory-scale (8 L effective volume) semi-continuous stirred tank reactors (designated R1 and R2). A reactor fed with CM only (R0) was used as control. The reactors were operated in the mesophilic range (37 °C) with a hydraulic retention time of 30 days, and the entire experiment lasted for 450 days. The rate of organic loading was raised by increasing the content of FWS in the feed stock. During the experiment, the amount (volume%) of FWS was increased stepwise in the following order: 3% – 6% – 13% – 16%, and 19%. Measurements of methane production, and analysis of volatile fatty acids, ammonium and pH in the effluents were carried out. The highest methane production from co-digestion of FWS and CM was 0.400 L CH4 gVS{sup −1}, obtained during the period with loading of 16% FWS in R2. Compared to anaerobic digestion of CM only, the methane production was increased by 100% at most, when FWS was added to the feed stock. The biogas processes failed in R1 and R2 during the periods, with loadings of 16% and 19% FWS, respectively. In both reactors, the biogas processes failed due to overloading and accumulation of ammonia and volatile fatty acids.

  15. A MULTISTAGE GRADUAL NITROGENREDUCTION STRATEGY FOR INCREASED LIPID PRODUCTIVITY AND NITROGEN REMOVAL IN WASTEWATER USING Chlorella vulgaris AND Scenedesmus obliquus

    Directory of Open Access Journals (Sweden)

    J. C. Robles-Heredia

    2015-06-01

    Full Text Available AbstractChlorella vulgaris and Scenedesmus obliquuswere grown in artificial-wastewater using a new nitrogen-limitation strategy aimed at increasing lipid productivity. This strategy consisted in a multi-stage process with sequential reduction of N-NH4 concentration (from 90 to 60, 40, and 20 mg.L-1 to promote a balance between cell growth and lipid accumulation. Lipid productivity was compared against a reference process consisting of nitrogen reduction in two stages, where the nitrogen concentration was suddenly reduced from 90 mg.L-1 to three different concentrations (10, 20, and 30 mg.L-1. In the multi-stage mode, only C. vulgaris exhibited a net lipid-productivity increase. Lipid content of S. obliquus did not present a significant increase, thus decreasing lipid productivity. The highest lipid productivities were observed in the two-stage mode for both S. obliquus and C. vulgaris (194.9 and 133.5 mg.L-1.d-1, respectively, and these values are among the highest reported in the literature to date.

  16. Thermal tolerance of Limnoperna fortunei to gradual temperature increase and its applications for biofouling control in industrial and power plants.

    Science.gov (United States)

    Perepelizin, Pablo V; Boltovskoy, Demetrio

    2011-07-01

    The acute upper lethal temperature (AULT) at different rates of increase was evaluated as a tool for the design of cheaper and environmentally friendlier control strategies for the invasive bivalve Limnoperna fortunei. Survivorship of 6 ± 2 mm and 20 ± 2 mm mussels acclimated to 12, 23 and 28 ° C and subjected to different heating rates (1 ° C per 5, 15 and 30 min) was estimated in the laboratory. The temperatures required to kill 50% (LT(50)) and 100% (SM(100)) of the mussels, and the mean death temperature (MDT) varied between 42.2 and 51 ° C over 54 experiments. Heating rates significantly (p industrial capacities, suggesting that heat treatment is a viable alternative for controlling its fouling in utility systems.

  17. Gradual Increase of FcγRIIIa/CD16a Expression and Shift toward IFN-γ Secretion during Differentiation of CD56dim Natural Killer Cells

    Directory of Open Access Journals (Sweden)

    Laurie Lajoie

    2017-11-01

    Full Text Available Natural killer (NK cell effector functions include cytotoxicity and secretion of cytokines such as interferon-γ (IFN-γ. The immature CD56bright subset of human NK cells lacks expression of FcγRIIIa/CD16a, one of the low-affinity immunoglobulin G receptors, or exhibits low-density expression (CD56brightCD16−/dim and produces IFN-γ in response to cytokine stimulation, whereas the mature CD56dimCD16+ subset is the most cytotoxic one. A further differentiation/maturation of the latter subset according to the gradual loss of NKG2A and/or gain of KIR2DL (CD158a and CD158b has been demonstrated and the ability to produce IFN-γ in response to activating receptor (AR co-engagement is gradually acquired during terminal differentiation. In the course of flow cytometry analysis of CD56dim NK cells, we noted a substantial intraindividual heterogeneity of expression of FcγRIIIa. FcγRIIIa is unique among ARs: it does not require the co-engagement of other ARs to induce substantial cytotoxicity or cytokine synthesis in CD56dim cells. We, therefore, investigated whether individual differentiation/maturation of polyclonal CD56dim NK cells defined by expression of NKG2A/KIR2DL is related to FcγRIIIa expression and to the heterogeneity of NK cell responses upon FcγRIIIa engagement. When we analyzed unstimulated CD56dim cells by increasing level of FcγRIIIa expression, we found that the proportion of the more differentiated CD158a,h+ and/or CD158b,j+ cells and that of the less differentiated NKG2A+ cells gradually increased and decreased, respectively. FcγRIIIa engagement by using plate-bound murine anti-CD16 monoclonal antibody (mAb or rituximab or trastuzumab (two therapeutic mAbs, resulted in donor-dependent partial segregation of IFN-γ-producing and/or degranulating CD56dim cells. Importantly, the proportion of CD158a,h/b,j+ cells and that of NKG2A+ cells was increased and decreased, respectively, IFN-γ-producing cells, whereas these proportions

  18. Towards Practical Gradual Typing

    OpenAIRE

    Takikawa, Asumu; Feltey, Daniel; Dean, Earl; Flatt, Matthew; Findler, Robert Bruce; Tobin-Hochstadt, Sam; Felleisen, Matthias

    2015-01-01

    Over the past 20 years, programmers have embraced dynamically-typed programming languages. By now, they have also come to realize that programs in these languages lack reliable type information for software engineering purposes. Gradual typing addresses this problem; it empowers programmers to annotate an existing system with sound type information on a piecemeal basis. This paper presents an implementation of a gradual type system for a full-featured class-based language as well as a novel p...

  19. A Successful Pregnancy by Utilization of Gradually Increasing Low Dose Gonadotrophin Stimulation in a Modified Natural Cycle in Vitro Fertilization Procedure: Case Report

    Directory of Open Access Journals (Sweden)

    Serkan Kahyaoğlu

    2016-05-01

    Full Text Available The modified natural cycle in vitro fertilization (MNC-IVF treatment can be a promising method for poor responder patients especially in young patients with poor ovarian reserve. A 34-year-old primary infertile woman presented with a history of poor ovarian response and cycle cancellation following controlled ovarian hyperstimulation during an IVF-ET procedure two months ago. During MNC-IVF treatment with intracytoplasmic sperm injection (ICSI, gradually increasing doses of hMG for three days (totally 675 IU have been administered accompanied by daily 0,25 mg cetrorelix. Following ovulation triggering, one oocyte was picked up and a good quality (grade 1 embryo was transferred on day 2. A clinical pregnancy was established with ultrasonography on sixth weeks of gestation. Acceptable pregnancy rates per embryo transfer, low medication cost, relatively low risk of complications and higher patient acceptability are the main advantages of MNC-IVF treatment as a feasible treatment option especially for poor responder patients.

  20. How to Increase the Efficiency and Reach of Email Marketing: Case Onninen Finland

    OpenAIRE

    Nuutinen, Sami

    2015-01-01

    This thesis took an analytical and practical approach on email marketing, and studied it from the perspective of the case study company Onninen. The aim was at finding out how to increase the efficiency and reach of email marketing at the case company. The case company, Onninen, is a large Finnish distributor of HVACR, steel, and electrical goods. Email marketing can be one of the most effective tools for marketers to invest in. In order to find solutions to the aforementioned aim of the...

  1. Gradual linguistic summaries

    NARCIS (Netherlands)

    Wilbik, A.M.; Kaymak, U.; Laurent, A.; Strauss, O.; Bouchon-Meunier, xx

    2014-01-01

    In this paper we propose a new type of protoform-based linguistic summary – the gradual summary. This new type of summaries aims in capturing the change over some time span. Such summaries can be useful in many domains, for instance in economics, e.g., "prices of X are getting smaller" in eldercare,

  2. Increasing reach by offering choices: Results from an innovative model for statewide services for smoking cessation.

    Science.gov (United States)

    Keller, Paula A; Schillo, Barbara A; Kerr, Amy N; Lien, Rebecca K; Saul, Jessie; Dreher, Marietta; Lachter, Randi B

    2016-10-01

    Although state quitlines provide free telephone counseling and often include nicotine replacement therapy (NRT), reach remains limited (1-2% in most states). More needs to be done to engage all smokers in the quitting process. A possible strategy is to offer choices of cessation services through quitlines and to reduce registration barriers. In March 2014, ClearWay Minnesota SM implemented a new model for QUITPLAN® Services, the state's population-wide cessation services. Tobacco users could choose the QUITPLAN® Helpline or one or more Individual QUITPLAN® Services (NRT starter kit, text messaging, email program, or quit guide). The program website was redesigned, online enrollment was added, and a new advertising campaign was created and launched. In 2014-2015, we evaluated whether these changes increased reach. We also assessed quit attempts, quit outcomes, predictors of 30-day abstinence, and average cost per quit via a seven-month follow-up survey. Between March 2014-February 2015, 15,861 unique tobacco users registered, which was a 169% increase over calendar year 2013. The majority of participants made a quit attempt (83.7%). Thirty-day point prevalence abstinence rates (responder rates) were 26.1% for QUITPLAN Services overall, 29.6% for the QUITPLAN Helpline, and 25.5% for Individual QUITPLAN Services. Several variables predicted quit outcomes, including receiving only one call from the Helpline and using both the Helpline and the NRT starter kit. Providing greater choice of cessation services and reducing registration barriers have the potential to engage more tobacco users, foster more quit attempts, and ultimately lead to long-term cessation and reductions in prevalence. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. The utility of Twitter as a tool for increasing reach of research on sexual violence.

    Science.gov (United States)

    Wekerle, Christine; Vakili, Negar; Stewart, Sherry H; Black, Tara

    2018-05-16

    Researchers in violence prevention areas seek to disseminate work for impact to practice and policy. Knowledge transfer, exchange, and mobilization are common terms for research knowledge utilization where public communication platforms are playing an increasing role, having unique capacity to connect stakeholders in advocacy and lived experience, academia, non-governmental organizations, government-supported organizations, such as child welfare, and research funding bodies. Social networking platforms provide a communication intervention opportunity to test the effectiveness of the research reach. A Canadian Institutes of Health Research- funded team grant in boys' and men's health, focusing on sexual violence (SV) victimization, health, and resilience undertook an evaluation to examine whether a strategic approach involving a cadre of SV experts (n = 46) and their research increased engagement. Using a unique identifier (#CIHRTeamSV) content was shared on social media (Twitter) within an ABABAB experimental monthly format (A = no sharing; B = sharing content), following a baseline entry of researchers. Active Twitter engagement lead to increases in the number of individuals' profile views, article downloads, and citations. These findings encourage further research into the utility of social media for disseminating sexual violence research, and that social media has developed as a forum for evidence-based conversation on sensitive topics of public health import. Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.

  4. How to Increase Reach and Adherence of Web-Based Interventions: A Design Research Viewpoint.

    Science.gov (United States)

    Ludden, Geke D S; van Rompay, Thomas J L; Kelders, Saskia M; van Gemert-Pijnen, Julia E W C

    2015-07-10

    Nowadays, technology is increasingly used to increase people's well-being. For example, many mobile and Web-based apps have been developed that can support people to become mentally fit or to manage their daily diet. However, analyses of current Web-based interventions show that many systems are only used by a specific group of users (eg, women, highly educated), and that even they often do not persist and drop out as the intervention unfolds. In this paper, we assess the impact of design features of Web-based interventions on reach and adherence and conclude that the power that design can have has not been used to its full potential. We propose looking at design research as a source of inspiration for new (to the field) design approaches. The paper goes on to specify and discuss three of these approaches: personalization, ambient information, and use of metaphors. Central to our viewpoint is the role of positive affect triggered by well-designed persuasive features to boost adherence and well-being. Finally, we discuss the future of persuasive eHealth interventions and suggest avenues for follow-up research.

  5. How to increase reach efficiency and effectiveness of Meo's digital marketing campaigns

    OpenAIRE

    Braga, Carolina

    2016-01-01

    Field lab: Business project This document is based on a master’s thesis work project conducted by Nova SBE students to help the leading Portuguese telecom provider MEO increase its digital campaign’s attractiveness and to take better advantage of the new online trends. Recommendations are given based on primary research in the form of a focus group and a survey questionnaire launched online. Subjects such as digital marketing channels, high-impact digital advertisement formats, campaign co...

  6. Increasing Contraceptive Access for Hard-to-Reach Populations With Vouchers and Social Franchising in Uganda.

    Science.gov (United States)

    Bellows, Benjamin; Mackay, Anna; Dingle, Antonia; Tuyiragize, Richard; Nnyombi, William; Dasgupta, Aisha

    2017-09-27

    From 2001 to 2011, modern contraceptive prevalence in Uganda increased from 18% to 26%. However, modern method use, in particular use of long-acting reversible contraceptives (LARCs) and permanent methods (PMs), remained low. In the 2011 Uganda Demographic and Health Survey, only 1 of 5 married women used a LARC or PM even though 34% indicated an unmet need for contraception. Between 2011 and 2014, a social franchise and family planning voucher program, supporting 400 private facilities to provide family planning counseling and broaden contraceptive choice by adding LARCs and PMs to the service mix, offered a voucher to enable poor women to access family planning services at franchised facilities. This study analyzes service trends and voucher client demographics and estimates the contribution of the program to increasing contraceptive prevalence in Uganda, using the Impact 2 model developed by Marie Stopes International. Between March 2011 and December 2014, 330,826 women received a family planning service using the voucher, of which 70% of voucher clients chose an implant and 25% chose an intrauterine device. The median age of voucher users was 28 years; 79% had no education or only a primary education; and 48% reported they were unemployed or a housewife. We estimated that by 2014, 280,000 of the approximately 8,600,000 women of reproductive age in Uganda were using a contraceptive method provided by the program and that 120,000 of the clients were "additional users" of contraception, contributing 1.4 percentage points to the national modern contraceptive prevalence rate. The combination of family planning vouchers and a franchise-based quality improvement initiative can leverage existing private health infrastructure to substantially expand family planning access and choice for disadvantaged populations and potentially improve contraceptive prevalence when scaled nationally. © Bellows et al.

  7. Increasing Contraceptive Access for Hard-to-Reach Populations With Vouchers and Social Franchising in Uganda

    Science.gov (United States)

    Bellows, Benjamin; Mackay, Anna; Dingle, Antonia; Tuyiragize, Richard; Nnyombi, William; Dasgupta, Aisha

    2017-01-01

    ABSTRACT From 2001 to 2011, modern contraceptive prevalence in Uganda increased from 18% to 26%. However, modern method use, in particular use of long-acting reversible contraceptives (LARCs) and permanent methods (PMs), remained low. In the 2011 Uganda Demographic and Health Survey, only 1 of 5 married women used a LARC or PM even though 34% indicated an unmet need for contraception. Between 2011 and 2014, a social franchise and family planning voucher program, supporting 400 private facilities to provide family planning counseling and broaden contraceptive choice by adding LARCs and PMs to the service mix, offered a voucher to enable poor women to access family planning services at franchised facilities. This study analyzes service trends and voucher client demographics and estimates the contribution of the program to increasing contraceptive prevalence in Uganda, using the Impact 2 model developed by Marie Stopes International. Between March 2011 and December 2014, 330,826 women received a family planning service using the voucher, of which 70% of voucher clients chose an implant and 25% chose an intrauterine device. The median age of voucher users was 28 years; 79% had no education or only a primary education; and 48% reported they were unemployed or a housewife. We estimated that by 2014, 280,000 of the approximately 8,600,000 women of reproductive age in Uganda were using a contraceptive method provided by the program and that 120,000 of the clients were “additional users” of contraception, contributing 1.4 percentage points to the national modern contraceptive prevalence rate. The combination of family planning vouchers and a franchise-based quality improvement initiative can leverage existing private health infrastructure to substantially expand family planning access and choice for disadvantaged populations and potentially improve contraceptive prevalence when scaled nationally. PMID:28963175

  8. Cost-effectiveness of increasing the reach of smoking cessation interventions in Germany: results from the EQUIPTMOD.

    Science.gov (United States)

    Huber, Manuel B; Präger, Maximilian; Coyle, Kathryn; Coyle, Doug; Lester-George, Adam; Trapero-Bertran, Marta; Nemeth, Bertalan; Cheung, Kei Long; Stark, Renee; Vogl, Matthias; Pokhrel, Subhash; Leidl, Reiner

    2017-12-15

    To evaluate costs, effects and cost-effectiveness of increased reach of specific smoking cessation interventions in Germany. A Markov-based state transition return on investment model (EQUIPTMOD) was used to evaluate current smoking cessation interventions as well as two prospective investment scenarios. A health-care perspective (extended to include out-of-pocket payments) with life-time horizon was considered. A probabilistic analysis was used to assess uncertainty concerning predicted estimates. Germany. Cohort of current smoking population (18+ years) in Germany. Interventions included group-based behavioural support, financial incentive programmes and varenicline. For prospective scenario 1 the reach of group-based behavioral support, financial incentive programme and varenicline was increased by 1% of yearly quit attempts (= 57 915 quit attempts), while prospective scenario 2 represented a higher reach, mirroring the levels observed in England. EQUIPTMOD considered reach, intervention cost, number of quitters, quality-of-life years (QALYs) gained, cost-effectiveness and return on investment. The highest returns through reduction in smoking-related health-care costs were seen for the financial incentive programme (€2.71 per €1 invested), followed by that of group-based behavioural support (€1.63 per €1 invested), compared with no interventions. Varenicline had lower returns (€1.02 per €1 invested) than the other two interventions. At the population level, prospective scenario 1 led to 15 034 QALYs gained and €27 million cost-savings, compared with current investment. Intervention effects and reach contributed most to the uncertainty around the return-on-investment estimates. At a hypothetical willingness-to-pay threshold of only €5000, the probability of being cost-effective is approximately 75% for prospective scenario 1. Increasing the reach of group-based behavioural support, financial incentives and varenicline for smoking cessation by

  9. Dietary changes needed to reach nutritional adequacy without increasing diet cost according to income: An analysis among French adults.

    Directory of Open Access Journals (Sweden)

    Matthieu Maillot

    Full Text Available To explore the dietary changes needed to achieve nutritional adequacy across income levels at constant energy and diet cost.Individual diet modelling was used to design iso-caloric, nutritionally adequate optimised diets for each observed diet in a sample of adult normo-reporters aged ≥20 years (n = 1,719 from the Individual and National Dietary Survey (INCA2, 2006-2007. Diet cost was estimated from mean national food prices (2006-2007. A first set of free-cost models explored the impact of optimisation on the variation of diet cost. A second set of iso-cost models explored the dietary changes induced by the optimisation with cost set equal to the observed one. Analyses of dietary changes were conducted by income quintiles, adjusting for energy intake, sociodemographic and socioeconomic variables, and smoking status.The cost of observed diets increased with increasing income quintiles. In free-cost models, the optimisation increased diet cost on average (+0.22 ± 1.03 euros/d and within each income quintile, with no significant difference between quintiles, but with systematic increases for observed costs lower than 3.85 euros/d. In iso-cost models, it was possible to design nutritionally adequate diets whatever the initial observed cost. On average, the optimisation at iso-cost increased fruits and vegetables (+171 g/day, starchy foods (+121 g/d, water and beverages (+91 g/d, and dairy products (+20 g/d, and decreased the other food groups (e.g. mixed dishes and salted snacks, leading to increased total diet weight (+300 g/d. Those changes were mostly similar across income quintiles, but lower-income individuals needed to introduce significantly more fruit and vegetables than higher-income ones.In France, the dietary changes needed to reach nutritional adequacy without increasing cost are similar regardless of income, but may be more difficult to implement when the budget for food is lower than 3.85 euros/d.

  10. The Gradual Evolution of Language

    Directory of Open Access Journals (Sweden)

    Michael C. Corballis

    2014-12-01

    Full Text Available Language is commonly held to be unique to humans, and to have emerged suddenly in a single “great leap forward” within the past 100,000 years. The view is profoundly anti-Darwinian, and I propose instead a framework for understanding how language might have evolved incrementally from our primate heritage. One major proposition is that language evolved from manual action, with vocalization emerging as the dominant mode late in hominin evolution. The second proposition has to do with the role of language as a means of communicating about events displaced in space and time from the present. Some have argued that mental time travel itself is unique to human, which might explain why language itself is uniquely human. I argue instead that mental time travel has ancient evolutionary origins, and gradually assumed narrative-like properties during the Pleistocene, when language itself began to take shape.

  11. Computation of gradually varied flow in compound open channel ...

    Indian Academy of Sciences (India)

    The flow of water in an open channel can be treated as steady, gradually varied flow for ... channel between two nodes is treated as a single reach to calculate the loss ... dition at control points and (iii) critical depth is also required to verify the ...

  12. Mind the gap - reaching the European target of a 2-year increase in healthy life years in the next decade

    DEFF Research Database (Denmark)

    Jagger, Carol; McKee, Martin; Christensen, Kaare

    2013-01-01

    BACKGROUND: The European Innovation Partnership on Active and Healthy Ageing seeks an increase of two healthy life years (HLY) at birth in the EU27 for the next 10 years. We assess the feasibility of doing so between 2010 and 2020 and the differential impact among countries by applying different...... of HLY/LE on year (seven countries retaining same HLY question) or extrapolating the average of HLY/LE in 2008 and 2009 to 2010 (20 countries and EU27). The first scenario continued these trends with three other scenarios exploring different HLY gap reductions between 2010 and 2020. RESULTS......: The estimated gap in HLY in 2010 was 17.5 years (men) and 18.9 years (women). Assuming current trends continue, EU27 HLY increased by 1.4 years (men) and 0.9 years (women), below the European Innovation Partnership on Active and Healthy Ageing target, with the HLY gap between countries increasing to 18.3 years...

  13. Inorganic/organic nanocomposites: Reaching a high filler content without increasing viscosity using core-shell structured nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Benhadjala, W., E-mail: warda.benhadjala@cea.fr [IMS Laboratory - UMR CNRS 5218, University of Bordeaux, 351 Cours de la Libération, 33405 Talence (France); CEA, LETI, Minatec Campus, 38000 Grenoble (France); Gravoueille, M.; Weiss, M. [EDF, Centre d' Expertise et d' Inspection dans les Domaines de la Réalisation et de l' Exploitation (CEIDRE), Chinon, BP 80, 37420 Avoine (France); Bord-Majek, I.; Béchou, L.; Ousten, Y. [IMS Laboratory - UMR CNRS 5218, University of Bordeaux, 351 Cours de la Libération, 33405 Talence (France); Suhir, E. [Maseeh College of Engineering and Computer Science, Portland State University, Oregon 97201 (United States); Buet, M.; Louarn, M.; Rougé, F.; Gaud, V. [Polyrise SAS, 16 Avenue Pey Berland, 33607 Pessac (France)

    2015-11-23

    Extensive research is being conducted on the development of inorganic/organic nanocomposites for a wide variety of applications in microelectronics, biotechnologies, photonics, adhesives, or optical coatings. High filler contents are usually required to fully optimize the nanocomposites properties. However, numerous studies demonstrated that traditional composite viscosity increases with increasing the filler concentration reducing therefore significantly the material processability. In this work, we synthesized inorganic/organic core-shell nanocomposites with different shell thicknesses. By reducing the shell thickness while maintaining a constant core size, the nanoparticle molecular mass decreases but the nanocomposite filler fraction is correlatively increased. We performed viscosity measurements, which clearly highlighted that intrinsic viscosity of hybrid nanoparticles decreases as the molecular mass decreases, and thus, as the filler fraction increases, as opposed to Einstein predictions about the viscosity of traditional inorganic/polymer two-phase mixtures. This exceptional behavior, modeled by Mark-Houwink-Sakurada equation, proves to be a significant breakthrough for the development of industrializable nanocomposites with high filler contents.

  14. Reaching the hard to reach.

    Science.gov (United States)

    Bhiwandi, P; Campbell, M; Potts, M

    1994-01-01

    The 1994 International Conference on Population and Development proposed increasing contraceptive couple protection from 550 million in 1995 to 880 million in 2015. The task for family planning (FP) programs is to provide access to services for, sometimes, inaccessible rural populations. FP need based on desire for no more children has ranged from under 20% in Senegal to almost 80% in Peru. Socioeconomic development was found not to be a prerequisite for fertility change. Gender inequalities in education and social autonomy must be changed. FP access is very important among women with a disadvantaged background or among women unsure about FP. Bangladesh is a good example of a country with increased contraceptive prevalence despite low income. The rule of thumb is that contraception increases of 15% contribute to a drop in family size of about one child. Program effectiveness is related to a variety of factors: contraceptive availability at many locations, acceptable price of contraception, delivery of the oral contraceptives without prescriptions, and other strategies. FP is a service not a medical treatment. A range of methods must be promoted and available from a range of facilities. Contraceptive use is dependent on the woman's stage in her lifecycle and is dependent on informed choice. Community-based distribution systems are effective, whereas free distribution by poorly-trained field workers is not always very effective because patient payment of all or part of the cost assures quality and freedom of choice. Effective programs for underprivileged groups involve aggressive, easy to manage programs that can be replicated rapidly. FP serves a useful function in depressing maternal mortality among the poor in Africa, who have no access to quality health services. Social marketing is an effective strategy for reaching remote areas. Political will and robust management are necessary commodities.

  15. Empirical tests of the Gradual Learning Algorithm

    NARCIS (Netherlands)

    Boersma, P.; Hayes, B.

    1999-01-01

    The Gradual Learning Algorithm (Boersma 1997) is a constraint ranking algorithm for learning Optimality-theoretic grammars. The purpose of this article is to assess the capabilities of the Gradual Learning Algorithm, particularly in comparison with the Constraint Demotion algorithm of Tesar and

  16. Empirical tests of the Gradual Learning Algorithm

    NARCIS (Netherlands)

    Boersma, P.; Hayes, B.

    2001-01-01

    The Gradual Learning Algorithm (Boersma 1997) is a constraint-ranking algorithm for learning optimality-theoretic grammars. The purpose of this article is to assess the capabilities of the Gradual Learning Algorithm, particularly in comparison with the Constraint Demotion algorithm of Tesar and

  17. The energetics of the gradual phase

    Science.gov (United States)

    Strong, K. T.; Bentley, R. D.; Bornmann, P. L.; Bruner, M. E.; Cargill, P. J.; Doyle, J. G.; Lemen, J. R.; Pallavicini, R.; Peres, G.; Serio, S.

    1986-01-01

    Reseachers compare results with those in the chapter by Moore et al. (1980), who reached five main conclusions about the gradual phase: (1) the typical density of the soft X-ray emitting plasma is between 10 to the 11th power and 10 to the 12th power cm-3 for compact flares and between 10 to the 10th power and 10 to the 11th power cm-3 for a large-area flare; (2) cooling is by conduction and radiation in roughly equal proportions; (3) continual heating is needed in the decay phase of two-ribbon flares; (4) continual heating is probably not needed in compact events; (5) most of the soft-X-ray-emitting plasma results from chromospheric evaporation. The goal was to reexamine these problems with the data from the Solar Maximum Mission (SMM) and other supporting instruments as well as to take advantage of recent theoretical advances. SMM is capable of measuring coronal temperatures more accurately and with a better cadence than has been possible before. The SMM data set is also unique in that the complete transit of an active region was observed, with soft X-ray and UV images being taken every few minutes. Researcher's were therefore able to establish the pre-flare conditions of the region and see whether anything has changed as a result of the flare. The assumptions made in attempting to determine the required plasma parameters are described. The derived parameters for the five prime flares are presented, and the role of numerical simulations is discussed.

  18. Gradual Hunterian ligation for infected prosthetic bypass.

    Science.gov (United States)

    Egun, A; Slade, D; McCollum, C N

    2000-04-01

    To review gradual snare occlusion for the management of complex or recurrent graft infection. Medical records of patients treated with gradual snare occlusion following graft infection were reviewed for indication for operation, type of bypass and graft material used. In addition, infecting organism, grade of infection (Szilágyi) and outcome were recorded. Four femoropopliteal, two extra-anatomic (axillofemoral) and aortobifemoral bypasses were included in this study. All had chronic infection (Szilágyi grade III) with onset of 4 to 24 months and two of which were recurrent. The causative organisms were coagulase-negative staphylococci, Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus in three patients, with no organism isolated in the remaining cases. There was no loss of limb following gradual snare occlusion but there was only one death due to aortic stump rupture 2 weeks later. Gradual snare occlusion is an alternative for the management of chronic or recurrent graft infection. Copyright 1999 Harcourt Publishers Ltd.

  19. VUJE tasks and activities during gradual upgrading

    International Nuclear Information System (INIS)

    Ferenc, M.

    2001-01-01

    The paper describes the organization and management of the Gradual Upgrading of the Bohunice V1 NPP and the principle tasks and scope of activities provided by VUJE Trnava, Inc. It also describes the system of supplies and the system of quality assurance both in the consortium and in subcontractors. (author)

  20. Using a Time Granularity Table for Gradual Granular Data Aggregation

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Pedersen, Torben Bach

    2014-01-01

    The majority of today’s systems increasingly require sophisticated data management as they need to store and to query large amounts of data for analysis and reporting purposes. In order to keep more “detailed” data available for longer periods, “old” data has to be reduced gradually to save space...

  1. Ratio-Based Gradual Aggregation of Data

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem

    2012-01-01

    cause data management and data storage issues. However, non-flexible and ineffective means of data aggregation not only reduce performance of database queries but also lead to erroneous reporting. This paper presents flexible and effective ratio-based methods for gradual data aggregation in databases....... Gradual data aggregation is a process that reduces data volume by converting the detailed data into multiple levels of summarized data as the data gets older. This paper also describes implementation strategies of the proposed methods based on standard database technology.......Majority of databases contain large amounts of data, gathered over long intervals of time. In most cases, the data is aggregated so that it can be used for analysis and reporting purposes. The other reason of data aggregation is to reduce data volume in order to avoid over-sized databases that may...

  2. Gradual Ordering in Red Abalone Nacre

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, P. U. P. A.; Metzler, Rebecca A.; Zhou, Dong; Scholl, Andreas; Doran, Andrew; Young, Anthony; Kunz, Martin; Tamura, Nobumichi; Coppersmith, Susan N.

    2008-09-03

    Red abalone (Haliotis rufescens) nacre is a layered composite biomineral that contains crystalline aragonite tablets confined by organic layers. Nacre is intensely studied because its biologically controlled microarchitecture gives rise to remarkable strength and toughness, but the mechanisms leading to its formation are not well understood. Here we present synchrotron spectromicroscopy experiments revealing that stacks of aragonite tablet crystals in nacre are misoriented with respect to each other. Quantitative measurements of crystal orientation, tablet size, and tablet stacking direction show that orientational ordering occurs not abruptly but gradually over a distance of 50 {micro}m. Several lines of evidence indicate that different crystal orientations imply different tablet growth rates during nacre formation. A theoretical model based on kinetic and gradual selection of the fastest growth rates produces results in qualitative and quantitative agreement with the experimental data and therefore demonstrates that ordering in nacre is a result of crystal growth kinetics and competition either in addition or to the exclusion of templation by acidic proteins as previously assumed. As in other natural evolving kinetic systems, selection of the fastest-growing stacks of tablets occurs gradually in space and time. These results suggest that the self-ordering of the mineral phase, which may occur completely independently of biological or organic-molecule control, is fundamental in nacre formation.

  3. Gradual Ordering in Red Abalone Nacre

    International Nuclear Information System (INIS)

    Gilbert, P.U.P.A.; Metzler, Rebecca A.; Zhou, Dong; Scholl, Andreas; Doran, Andrew; Young, Anthony; Kunz, Martin; Tamura, Nobumichi; Coppersmith, Susan N.

    2008-01-01

    Red abalone (Haliotis rufescens) nacre is a layered composite biomineral that contains crystalline aragonite tablets confined by organic layers. Nacre is intensely studied because its biologically controlled microarchitecture gives rise to remarkable strength and toughness, but the mechanisms leading to its formation are not well understood. Here we present synchrotron spectromicroscopy experiments revealing that stacks of aragonite tablet crystals in nacre are misoriented with respect to each other. Quantitative measurements of crystal orientation, tablet size, and tablet stacking direction show that orientational ordering occurs not abruptly but gradually over a distance of 50 (micro)m. Several lines of evidence indicate that different crystal orientations imply different tablet growth rates during nacre formation. A theoretical model based on kinetic and gradual selection of the fastest growth rates produces results in qualitative and quantitative agreement with the experimental data and therefore demonstrates that ordering in nacre is a result of crystal growth kinetics and competition either in addition or to the exclusion of templation by acidic proteins as previously assumed. As in other natural evolving kinetic systems, selection of the fastest-growing stacks of tablets occurs gradually in space and time. These results suggest that the self-ordering of the mineral phase, which may occur completely independently of biological or organic-molecule control, is fundamental in nacre formation

  4. Genetic Improvements in Rice Yield and Concomitant Increases in Radiation- and Nitrogen-Use Efficiency in Middle Reaches of Yangtze River

    Science.gov (United States)

    Zhu, Guanglong; Peng, Shaobing; Huang, Jianliang; Cui, Kehui; Nie, Lixiao; Wang, Fei

    2016-01-01

    The yield potential of rice (Oryza sativa L.) has experienced two significant growth periods that coincide with the introduction of semi-dwarfism and the utilization of heterosis. In present study, we determined the annual increase in the grain yield of rice varieties grown from 1936 to 2005 in Middle Reaches of Yangtze River and examined the contributions of RUE (radiation-use efficiency, the conversion efficiency of pre-anthesis intercepted global radiation to biomass) and NUE (nitrogen-use efficiency, the ratio of grain yield to aboveground N accumulation) to these improvements. An examination of the 70-year period showed that the annual gains of 61.9 and 75.3 kg ha−1 in 2013 and 2014, respectively, corresponded to an annual increase of 1.18 and 1.16% in grain yields, respectively. The improvements in grain yield resulted from increases in the harvest index and biomass, and the sink size (spikelets per panicle) was significantly enlarged because of breeding for larger panicles. Improvements were observed in RUE and NUE through advancements in breeding. Moreover, both RUE and NUE were significantly correlated with the grain yield. Thus, our study suggests that genetic improvements in rice grain yield are associated with increased RUE and NUE. PMID:26876641

  5. Reaching Out

    Science.gov (United States)

    Moore, John W.

    1999-11-01

    . The first issue of this Journal described an outreach effort to place portraits of great American chemists in schools throughout the country, and a 1925 article dealt with "Educating the Public in the Use of the Metric System". A search of the JCE Online Index reveals many articles about chemistry and the public, with the number per year increasing steadily. During the last decade, for example, there have been 16 articles whose titles include "outreach" and many more that describe programs and resources for the general public. Current outreach efforts include a much broader range of activities and media. Hands-on science has become very popular, but so has virtual science on the World Wide Web. A combination of the two, which is aimed at K-8 children, can be found at the ACS Education Division's WonderNet site (http://www.acs.org/wondernet/). For older children there is Your Virtual Chemistry Club (http://www.acs.org/vc2/). Many more ACS outreach materials are described at their Web site. Outreach activities described in this Journal include programs in which high school, college, or graduate students visit schools and work with children and teachers, events in which participants compete to carry out chemical tasks, programs aimed at women and minorities, van programs in which chemicals and instruments are transported throughout broad geographical areas to support teachers and students, chemistry summer camps, and many others. The International Chemistry Olympiad (see report on page 1480) involves large numbers of students and ACS local sectionsand more than 50 countries. Outreach to outreach leaders is provided by the Institute for Chemical Education, which distributes booklets that explain how to organize and carry out programs (http://ice.chem.wisc.edu/ice/). The concept that the public is interested in science and can benefit from learning about science has expanded far beyond what Count Rumford could have imagined. Today we have books, magazines, videos

  6. Siemens tasks and activities during gradual upgrading

    International Nuclear Information System (INIS)

    Kuehne, B.

    2001-01-01

    The gradual upgrading of NPP V1 Bohunice constitutes the most extensive reconstruction project to be performed in an operational WWER plant to date. It constitutes a milestone in Siemens co-operation on projects for WWERs to date and is an encouraging example for the successful combination of western and eastern safety cultures. During the runtime of this project Siemens learnt very much about the 'complete function' as well as the details of this WWER plant type. In contrast the Slovakian partners really gained a much better understanding for the western approach to ensure safety, for the most modern safety technology, in particular for instrumentation and control, and last but not least or advanced project management. (author)

  7. Economic analysis of gradual "social exhaustion" of waste management capacity.

    Science.gov (United States)

    Koide, Hideo; Nakayama, Hirofumi

    2013-12-01

    This article proposes to analyze the quantitative effects of a gradual physical and "social" exhaustion of a landfill site on an equilibrium waste management service. A gradual social exhaustion of a landfill is defined here as an upward shift of a "subjective factor" associated with the amount of waste, based on the plausible hypothesis that an individual will not accept excessive presence of landfilled waste. Physical exhaustion occurs when the absolute capacity of a landfill site decreases. The paper shows some numerical examples using specific functions and parameters, and proposes appropriate directions for three policy objectives: to decrease the equilibrium waste disposal, to increase the economic surplus of the individual and/or the waste management firm, and to lower the equilibrium collection fee. Copyright © 2013 The Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

  8. Using Consumer Preference Information to Increase the Reach and Impact of Media-Based Parenting Interventions in a Public Health Approach to Parenting Support

    Science.gov (United States)

    Metzler, Carol W.; Sanders, Matthew R.; Rusby, Julie C.; Crowley, Ryann N.

    2012-01-01

    Within a public health approach to improving parenting, the mass media offer a potentially more efficient and affordable format for directly reaching a large number of parents with evidence-based parenting information than do traditional approaches to parenting interventions that require delivery by a practitioner. Little is known, however, about…

  9. Arterial wave reflection decreases gradually from supine to upright

    DEFF Research Database (Denmark)

    van den Bogaard, Bas; Westerhof, Berend E; Best, Hendrik

    2011-01-01

    BACKGROUND. An increase in total peripheral resistance (TPR) usually increases arterial wave reflection. During passive head-up tilt (HUT), however, arterial wave reflection decreases with increasing TPR. This study addressed whether arterial wave reflection gradually decreases during HUT. METHODS....... In 10 healthy volunteers (22-39 years, nine males), we recorded finger arterial pressures in supine position (0°), and 30°and 70°degrees HUT and active standing (90°). Aortic pressure was constructed from the finger pressure signal and hemodynamics were calculated. Arterial wave reflection...... from 0.9 dyn s/cm(5) at 0? to 1.2, 1.4 and 1.4 dyn s/cm(5) at 30°, 70° and 90° (p wave reflection...

  10. Does Digital Video Advertising Increase Population-Level Reach of Multimedia Campaigns? Evidence From the 2013 Tips From Former Smokers Campaign

    OpenAIRE

    Davis, Kevin C; Shafer, Paul R; Rodes, Robert; Kim, Annice; Hansen, Heather; Patel, Deesha; Coln, Caryn; Beistle, Diane

    2016-01-01

    Background Federal and state public health agencies in the United States are increasingly using digital advertising and social media to promote messages from broader multimedia campaigns. However, little evidence exists on population-level campaign awareness and relative cost efficiencies of digital advertising in the context of a comprehensive public health education campaign. Objective Our objective was to compare the impact of increased doses of digital video and television advertising fro...

  11. The gradual nature of threshold switching

    International Nuclear Information System (INIS)

    Wimmer, M; Salinga, M

    2014-01-01

    The recent commercialization of electronic memories based on phase change materials proved the usability of this peculiar family of materials for application purposes. More advanced data storage and computing concepts, however, demand a deeper understanding especially of the electrical properties of the amorphous phase and the switching behaviour. In this work, we investigate the temporal evolution of the current through the amorphous state of the prototypical phase change material, Ge 2 Sb 2 Te 5 , under constant voltage. A custom-made electrical tester allows the measurement of delay times over five orders of magnitude, as well as the transient states of electrical excitation prior to the actual threshold switching. We recognize a continuous current increase over time prior to the actual threshold-switching event to be a good measure for the electrical excitation. A clear correlation between a significant rise in pre-switching-current and the later occurrence of threshold switching can be observed. This way, we found experimental evidence for the existence of an absolute minimum for the threshold voltage (or electric field respectively) holding also for time scales far beyond the measurement range. (paper)

  12. Mind the gap--reaching the European target of a 2-year increase in healthy life years in the next decade.

    Science.gov (United States)

    Jagger, Carol; McKee, Martin; Christensen, Kaare; Lagiewka, Karolina; Nusselder, Wilma; Van Oyen, Herman; Cambois, Emmanuelle; Jeune, Bernard; Robine, Jean-Marie

    2013-10-01

    The European Innovation Partnership on Active and Healthy Ageing seeks an increase of two healthy life years (HLY) at birth in the EU27 for the next 10 years. We assess the feasibility of doing so between 2010 and 2020 and the differential impact among countries by applying different scenarios to current trends in HLY. Data comprised HLY and life expectancy (LE) at birth 2004-09 from Eurostat. We estimated HLY in 2010 in each country by multiplying the Eurostat projections of LE in 2010 by the ratio HLY/LE obtained either from country and sex-specific linear regression models of HLY/LE on year (seven countries retaining same HLY question) or extrapolating the average of HLY/LE in 2008 and 2009 to 2010 (20 countries and EU27). The first scenario continued these trends with three other scenarios exploring different HLY gap reductions between 2010 and 2020. The estimated gap in HLY in 2010 was 17.5 years (men) and 18.9 years (women). Assuming current trends continue, EU27 HLY increased by 1.4 years (men) and 0.9 years (women), below the European Innovation Partnership on Active and Healthy Ageing target, with the HLY gap between countries increasing to 18.3 years (men) and 19.5 years (women). To eliminate the HLY gap in 20 years, the EU27 must gain 4.4 HLY (men) and 4.8 HLY (women) in the next decade, which, for some countries, is substantially more than what the current trends suggest. Global targets for HLY move attention from inter-country differences and, alongside the current economic crisis, may contribute to increase health inequalities.

  13. A Randomized Trial to Compare Alternative Educational Interventions to Increase Colorectal Cancer Screening in a Hard-to-Reach Urban Minority Population with Health Insurance.

    Science.gov (United States)

    Basch, Charles E; Zybert, Patricia; Wolf, Randi L; Basch, Corey H; Ullman, Ralph; Shmukler, Celia; King, Fionnuala; Neugut, Alfred I; Shea, Steven

    2015-10-01

    This randomized controlled trial assessed different educational approaches for increasing colorectal cancer screening uptake in a sample of primarily non-US born urban minority individuals, over aged 50, with health insurance, and out of compliance with screening guidelines. In one group, participants were mailed printed educational material (n = 180); in a second, participants' primary care physicians received academic detailing to improve screening referral and follow-up practices (n = 185); in a third, physicians received academic detailing and participants received tailored telephone education (n = 199). Overall, 21.5% of participants (n = 121) received appropriate screening within one year of randomization. There were no statistically significant pairwise differences between groups in screening rate. Among those 60 years of age or older, however, the detailing plus telephone education group had a higher screening rate than the print group (27.3 vs. 7.7%, p = .02). Different kinds of interventions will be required to increase colorectal cancer screening among the increasingly small population segment that remains unscreened. ClinicalTrials.gov Identifier: NCT02392143.

  14. Solar Hydrogen Reaching Maturity

    Directory of Open Access Journals (Sweden)

    Rongé Jan

    2015-09-01

    Full Text Available Increasingly vast research efforts are devoted to the development of materials and processes for solar hydrogen production by light-driven dissociation of water into oxygen and hydrogen. Storage of solar energy in chemical bonds resolves the issues associated with the intermittent nature of sunlight, by decoupling energy generation and consumption. This paper investigates recent advances and prospects in solar hydrogen processes that are reaching market readiness. Future energy scenarios involving solar hydrogen are proposed and a case is made for systems producing hydrogen from water vapor present in air, supported by advanced modeling.

  15. Does Digital Video Advertising Increase Population-Level Reach of Multimedia Campaigns? Evidence From the 2013 Tips From Former Smokers Campaign.

    Science.gov (United States)

    Davis, Kevin C; Shafer, Paul R; Rodes, Robert; Kim, Annice; Hansen, Heather; Patel, Deesha; Coln, Caryn; Beistle, Diane

    2016-09-14

    Federal and state public health agencies in the United States are increasingly using digital advertising and social media to promote messages from broader multimedia campaigns. However, little evidence exists on population-level campaign awareness and relative cost efficiencies of digital advertising in the context of a comprehensive public health education campaign. Our objective was to compare the impact of increased doses of digital video and television advertising from the 2013 Tips From Former Smokers (Tips) campaign on overall campaign awareness at the population level. We also compared the relative cost efficiencies across these media platforms. We used data from a large national online survey of approximately 15,000 US smokers conducted in 2013 immediately after the conclusion of the 2013 Tips campaign. These data were used to compare the effects of variation in media dose of digital video and television advertising on population-level awareness of the Tips campaign. We implemented higher doses of digital video among selected media markets and randomly selected other markets to receive similar higher doses of television ads. Multivariate logistic regressions estimated the odds of overall campaign awareness via digital or television format as a function of higher-dose media in each market area. All statistical tests used the .05 threshold for statistical significance and the .10 level for marginal nonsignificance. We used adjusted advertising costs for the additional doses of digital and television advertising to compare the cost efficiencies of digital and television advertising on the basis of costs per percentage point of population awareness generated. Higher-dose digital video advertising was associated with 94% increased odds of awareness of any ad online relative to standard-dose markets (Pdigital advertising was associated with a marginally nonsignificant increase (46%) in overall campaign awareness regardless of media format (P=.09). Higher

  16. Does Digital Video Advertising Increase Population-Level Reach of Multimedia Campaigns? Evidence From the 2013 Tips From Former Smokers Campaign

    Science.gov (United States)

    Shafer, Paul R; Rodes, Robert; Kim, Annice; Hansen, Heather; Patel, Deesha; Coln, Caryn; Beistle, Diane

    2016-01-01

    Background Federal and state public health agencies in the United States are increasingly using digital advertising and social media to promote messages from broader multimedia campaigns. However, little evidence exists on population-level campaign awareness and relative cost efficiencies of digital advertising in the context of a comprehensive public health education campaign. Objective Our objective was to compare the impact of increased doses of digital video and television advertising from the 2013 Tips From Former Smokers (Tips) campaign on overall campaign awareness at the population level. We also compared the relative cost efficiencies across these media platforms. Methods We used data from a large national online survey of approximately 15,000 US smokers conducted in 2013 immediately after the conclusion of the 2013 Tips campaign. These data were used to compare the effects of variation in media dose of digital video and television advertising on population-level awareness of the Tips campaign. We implemented higher doses of digital video among selected media markets and randomly selected other markets to receive similar higher doses of television ads. Multivariate logistic regressions estimated the odds of overall campaign awareness via digital or television format as a function of higher-dose media in each market area. All statistical tests used the .05 threshold for statistical significance and the .10 level for marginal nonsignificance. We used adjusted advertising costs for the additional doses of digital and television advertising to compare the cost efficiencies of digital and television advertising on the basis of costs per percentage point of population awareness generated. Results Higher-dose digital video advertising was associated with 94% increased odds of awareness of any ad online relative to standard-dose markets (Pdigital advertising was associated with a marginally nonsignificant increase (46%) in overall campaign awareness regardless of

  17. Comparing abrupt and gradual smoking cessation: a randomized trial.

    Science.gov (United States)

    Etter, Jean-François

    2011-11-01

    To compare abrupt and gradual smoking cessation. Randomized trial and observational study, Internet, 2007-2010. Smokers with no strong preference for abrupt or gradual quitting were randomly assigned to quitting immediately (n=472), or to gradually reducing their cigarette consumption over 2 weeks and then quit (n=502). Smokers who strongly preferred to quit abruptly were instructed to do so immediately (n=2456), those who strongly preferred gradual were instructed to reduce their cigarette consumption over 2 weeks, then quit (n=1801). Follow-up was conducted 4 weeks after target quit dates. Those who preferred abrupt quitting were the most motivated to quit and the most confident in their ability to quit. At follow-up, quit rates were 16% in those who preferred abrupt cessation, 7% in those who preferred gradual cessation and 9% in those who had no preference (pmotivation to quit and confidence in ability to quit: those who had low levels of motivation or low levels of confidence were more likely to quit at follow-up if they preferred and used abrupt rather than gradual. In those who had no strong preference for either method, abrupt and gradual produced similar results. Those who preferred and used the abrupt method were more likely to quit than those who preferred and used the gradual method, in particular when they had low motivation and confidence. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  18. Reach Address Database (RAD)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Reach Address Database (RAD) stores the reach address of each Water Program feature that has been linked to the underlying surface water features (streams,...

  19. Gradual instrumentation and control upgrades in U.S. nuclear power plants

    International Nuclear Information System (INIS)

    Welk, S.

    1997-01-01

    Since the late 1980s, US nuclear power plants have been struggling with the technical and licensing realities associated with installing digital protection and control systems into existing facilities. The industry, regulators and equipment vendors are finally reaching agreements regarding acceptable practices and requirements. The present paper explains the philosophy for gradual instrumentation and control replacements being pursued and the technical issues being addressed. It also describes some of the future challenges facing the industry. (author)

  20. Reaching the hard-to-reach.

    Science.gov (United States)

    Valdes, C

    1992-01-01

    Guatemala's family planning (FP) programs are innovative but contraceptive use is only 23%. Total fertility is 5.3 children/woman, and the 9.5 million population will double in 23 years. The problem is poverty and illiteracy among rural residents removed from health services. 80% live in poverty and 80% are illiterate. Government effort is devoted to combating diseases such as diarrhea so there are few funds for implementing a comprehensive population policy. There is support within the national government but FP lacks priority status. APROFAM's goals are to use innovative marketing methods to inform the rural population who lack access to and knowledge about FP. Service delivery is constrained by the difficulty in reaching remote areas where 4 out of 10 indigenous Guatemalans live. Infant mortality can reach as high as 200/1000 live births. Population growth has slowed, and APROFAM plans to reach 16,000 more in the future. Promotions are conducted in several languages and aired on radio, television, and in the print media. It has been found that market research is the most effective strategy in reaching indigenous families. APROFAM has also been effective in upgrading service facilities through training, client surveys, and setting improved clinic standards. Breastfeeding, training, and voluntary sterilization programs contribute to the primary care effort. The example is given of Paulina Lebron from a very poor area who has learned how to space her children and thus improve the standard of living for her family. Eventually, she convinced herself and her family that sterilization was necessary, and now the couple enjoy the bliss of newlyweds without fear of pregnancy.

  1. BROOKHAVEN: Proton goal reached

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    On March 30 the 35-year old Alternating Gradient Synchrotron (AGS) exceeded its updated design goal of 6 x 10 13 protons per pulse (ppp), by accelerating 6.3 x 10 13 ppp, a world record intensity. This goal was set 11 years ago and achieving it called for the construction of a new booster and the reconstruction of much of the AGS. The booster was completed in 1991, and reached its design intensity of 1.5 x 10 13 ppp in 1993. The AGS reconstruction was finished in 1994, and by July of that year the AGS claimed a new US record intensity for a proton synchrotron of 4 x 10 13 ppp, using four booster pulses. Reaching the design intensity was scheduled for 1995. In 1994, the AGS had seemed to be solidly limited to 4 x 10 13 ppp, but in 1995 the operations crew, working on their own in the quiet of the owl shift, steadily improved the intensity, regularly setting new records, much to the bemusement of the machine physicists. The physicists, however, did contribute. A second harmonic radiofrequency cavity in the booster increased the radiofrequency bucket area for capture, raising the booster intensity from 1.7 to 2.1 x 10 13 ppp. In the AGS, new radiofrequency power supplies raised the available voltage from 8 to 13 kV, greatly enhancing the beam loading capabilities of the system. A powerful new transverse damping system successfully controlled instabilities that otherwise would have destroyed the beam in less than a millisecond. Also in the AGS, 35th harmonic octupole resonances were found

  2. BROOKHAVEN: Proton goal reached

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1995-09-15

    On March 30 the 35-year old Alternating Gradient Synchrotron (AGS) exceeded its updated design goal of 6 x 10{sup 13} protons per pulse (ppp), by accelerating 6.3 x 10{sup 13} ppp, a world record intensity. This goal was set 11 years ago and achieving it called for the construction of a new booster and the reconstruction of much of the AGS. The booster was completed in 1991, and reached its design intensity of 1.5 x 10{sup 13} ppp in 1993. The AGS reconstruction was finished in 1994, and by July of that year the AGS claimed a new US record intensity for a proton synchrotron of 4 x 10{sup 13} ppp, using four booster pulses. Reaching the design intensity was scheduled for 1995. In 1994, the AGS had seemed to be solidly limited to 4 x 10{sup 13} ppp, but in 1995 the operations crew, working on their own in the quiet of the owl shift, steadily improved the intensity, regularly setting new records, much to the bemusement of the machine physicists. The physicists, however, did contribute. A second harmonic radiofrequency cavity in the booster increased the radiofrequency bucket area for capture, raising the booster intensity from 1.7 to 2.1 x 10{sup 13} ppp. In the AGS, new radiofrequency power supplies raised the available voltage from 8 to 13 kV, greatly enhancing the beam loading capabilities of the system. A powerful new transverse damping system successfully controlled instabilities that otherwise would have destroyed the beam in less than a millisecond. Also in the AGS, 35th harmonic octupole resonances were found.

  3. A Laboratory Experiment on the Evolution of a Sand Gravel Reach Under a Lack of Sediment Supply

    Science.gov (United States)

    Orru, C.; Chavarrias, V.; Ferrara, V.; Blom, A.

    2014-12-01

    A flume experiment was conducted to examine the evolution of a sand-gravel reach under a lack of sediment supply. The experimental data are used to validate a numerical sand-gravel model. A bed composed of a bi-modal sediment mixture is installed with a uniform slope and an imposed gradual fining pattern. Initially, the sand fraction gradually increases in streamwise direction until the bed is fully composed of sand. The water discharge and downstream water level were constant, and the sediment feed rate was equal to zero. The experiment was dominated by bed load, partial transport, and a subcritical flow regime was imposed. The flow rate was such that only sand was mobile (partial transport), which led to a coarsening over the upstream reach and a gradual reduction of the sediment transport rate during the experiment. New equipment was used to measure the evolution of the grain size distribution of the bed surface during the experiment over the entire flume using image analysis. In the upstream reach we observed a gradual coarsening over time and the formation of an armour layer, which resulted in a more abrupt transition in grain size of the bed surface. Bed degradation increased in streamwise direction. This is due to the initial streamwise increase in the availability of sand in the bed. The different volume fraction content of sand in the bed allowed for the gravel to sink more in the downstream part of the upstream reach. The sand reach suffered from a larger degradation. Finally, we see one reach dominated by sand, small bedforms, and a small bed slope, and a gravel reach dominated by a larger bed slope.

  4. Gradual reintroduction of oxygen reduces reperfusion injury in cat stomach

    International Nuclear Information System (INIS)

    Perry, M.A.; Wadhwa, S.S.

    1988-01-01

    Recent studies have shown that oxygen-derived free radicals are responsible for a major portion of ischemia-reperfusion injury in the stomach. The oxygen radicals are produced during perfusion when oxygen delivery to the tissue increases. In the present study the authors investigate the effect on mucosal injury of regulating the rate of reintroduction of oxygen to the stomach after ischemia. Local gastric ischemia was achieved by reducing celiac artery pressure to 30 mmHg for 1 h. Ischemic injury was assessed by measuring the loss of 51 Cr-labeled red blood cells across the gastric mucosa. Mucosal blood loss was negligible before and during the ischemia period but increased during reperfusion. When blood flow to the stomach was gradually returned to normal after ischemia, the mucosal blood loss was reduced. If the stomach was vascularly perfused with low Po 2 blood for 1 h after ischemia before being returned to normal arterial perfusion, the mucosal blood loss was also reduced. When the stomach was made hypoxemic for 1 h rather than ischemic by perfusing the vasculature with low Po 2 blood then reperfused with normoxic blood, there was very little mucosal bleeding. The data indicate that gastric mucosal bleeding after ischemia is reduced if the tissue is returned slowly to a normal Po 2 . These findings support the concept that reperfusion injury is due largely to the production of oxygen radicals. The low level of injury produced by hypoxemia indicates that hypoxia per se makes only a minor contribution to reperfusion injury in the stomach

  5. Using a Time Granularity Table for Gradual Granular Data Aggregation

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Pedersen, Torben Bach

    2010-01-01

    solution for data reduction based on gradual granular data aggregation. With the gradual granular data aggregation mechanism, older data can be made coarse-grained while keeping the newest data fine-grained. For instance, when data is 3 months old aggregate to 1 minute level from 1 second level, when data...... and improve query performance, especially on resource-constrained systems with limited storage and query processing capabilities. A number of data reduction solutions have been developed, however an effective solution particularly based on gradual data reduction is missing. This paper presents an effective...... is 6 months old aggregate to 2 minutes level from 1 minute level and so on. The proposed solution introduces a time granularity based data structure, namely a relational time granularity table that enables long term storage of old data by maintaining it at different levels of granularity and effective...

  6. Teratology testing under REACH.

    Science.gov (United States)

    Barton, Steve

    2013-01-01

    REACH guidelines may require teratology testing for new and existing chemicals. This chapter discusses procedures to assess the need for teratology testing and the conduct and interpretation of teratology tests where required.

  7. Global reach and engagement

    Science.gov (United States)

    2016-09-01

    Popular culture reflects both the interests of and the issues affecting the general public. As concerns regarding climate change and its impacts grow, is it permeating into popular culture and reaching that global audience?

  8. Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano

    Directory of Open Access Journals (Sweden)

    Braeckman Bart P

    2009-07-01

    Full Text Available Abstract Free-living flatworms ("Turbellaria" are appropriate model organisms to gain better insight into the role of stem cells in ageing and rejuvenation. Ageing research in flatworms is, however, still scarce. This is partly due to culture difficulties and the lack of a complete set of demographic data, including parameters such as median lifespan and age-specific mortality rate. In this paper, we report on the first flatworm survival analysis. We used the species Macrostomum lignano, which is an emerging model for studying the reciprocal influence between stem cells, ageing and rejuvenation. This species has a median lifespan of 205 ± 13 days (average ± standard deviation [SD] and a 90th percentile lifespan of 373 ± 32 days. The maximum lifespan, however, is more than 745 days, and the average survival curve is characterised by a long tail because a small number of individuals lives twice as long as 90% of the population. Similar to earlier observations in a wide range of animals, in M. lignano the age-specific mortality rate increases exponentially, but levels off at the oldest ages. To compare the senescence of M. lignano with that of other ageing models, we determined the mortality rate doubling time, which is 0.20 ± 0.02 years. As a result, we can conclude that M. lignano shows gradual senescence at a rate similar to the vertebrate ageing models Rattus norvegicus and Mus musculus. We argue that M. lignano is a suitable model for ageing and rejuvenation research, and especially for the role of stem cells in these processes, due to its accessible stem cell system and regeneration capacity, and the possibility of combining stem cell studies with demographic analyses.

  9. Increasing the reach of the PK-3R continuous Miner; Desarrollo y Ensayo de un Sistema para aumentar el alcance de la Pina de Rozado en un Minador PK-3R

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    The objective of this project is the development and implementation of a system designed to increase the reach of the cutting head of a PK-3R continuous miner working in our coal operations. Justification for the project stems from our method of coal extraction, whereby once the sub-level gallery has been advanced to it`s limit, extraction of the coal is undertaken by retreat mining, using a room and pillar method. In this method the roof is blasted to allow greater coal recovery. Due to it`s short length, the original position of the cutting arm of the PK-3R miner did not permit the total recovery of the blasted coal piled up on the gallery floor. Therefore an increase in the reach of the arm is very beneficial, facilitating the recovery of coal that previously could not be recovered. The system also permits excavation for support methods to be undertaken more rapidly, and a better adaptation of the miner to the irregularities of the wall, thus permitting it to move up or down more quickly, reducing the movements required. The system has not caused significant breakdowns, and the availability of the miner is good. In addition, the substitution of the turret in the case of a breakdown is an easy task, as during the design stage, the ease of mounting and dismounting the turret was considered as a fundamental parameter. (Author)

  10. Implications of a fossil stickleback assemblage for Darwinian gradualism.

    Science.gov (United States)

    Bell, M A

    2009-11-01

    Darwin postulated that a complete fossil record would contain numerous gradual transitions between ancestral and descendant species, but 150 years after publication of The Origin of Species, few such transitions have materialized. The fossil stickleback Gasterosteus doryssus and the deposit in which it occurs provide excellent conditions to detect such transitions. Abundant, well-preserved fossils occur in a stratigraphic setting with fine temporal resolution. The paleoecology of G. doryssus resembles the ecology of modern lakes that harbour the phenotypically similar three-spined stickleback Gasterosteus aculeatus. Gasterosteus aculeatus are primitively highly armoured, but G. doryssus comprised two contemporaneous biological species with relatively weak armour, including a near-shore, benthic feeder (benthic) and an offshore planktivore (limnetic). The benthic species expanded its range into the limnetic zone of the lake, where it apparently switched to planktivory and evolved reduced armour within c. 5000 years in response to directional selection. Although gradual evolution of mean phenotypes occurred, a single major gene caused much of evolutionary change of the pelvic skeleton. Thus, Darwin's expectation that transitions between species in the fossil record would be gradual was met at a fine time scale, but for pelvic structure, a well-studied trait, his expectation that gradual change would depend entirely on numerous, small, heritable differences among individuals was incorrect.

  11. Influence of Gradual Elongation to the Patella Tendon Insertion in Rabbits

    Directory of Open Access Journals (Sweden)

    Hirotaka Mutsuzaki

    2014-08-01

    Full Text Available The purpose of this study was to examine the histological changes at the patella tendon (PT insertion site under gradual elongation in rabbits. Gradual elongation of the PT was performed using external fixation for 4 weeks, with a lengthening speed of 0.5 mm/day (elongation group; n = 24. Rabbits in the sham group underwent the same surgical procedure without gradual elongation (sham group; n = 24. Eight animals were sacrificed 1, 2 and 4 weeks after surgery in each group, respectively. Average thicknesses of stained glycosaminoglycan (GAGs areas by Safranin-O staining in the total cartilage layer and the uncalcified fibrocartilage layer in the elongation group were significantly higher than that in the sham group at 4 weeks (p < 0.05 and that in the intact PT group (n = 6, p < 0.05. In the elongation group, the peak in the average thicknesses of the stained GAGs areas in the total cartilage layer and the uncalcified fibrocartilage layer were observed at 4 weeks. Gradual elongation of PT insertion significantly affected the increase in the average thicknesses of the stained GAGs areas in the cartilage layer especially in the uncalcified fibrocartilage layer at 4 weeks in rabbits. Clinically, insertions of tendon and ligament can extend during gradual elongation using external fixation more than 4 weeks after the operation.

  12. Sudden versus gradual pressure wean from Nasal CPAP in preterm infants: a randomized controlled trial.

    Science.gov (United States)

    Amatya, S; Macomber, M; Bhutada, A; Rastogi, D; Rastogi, S

    2017-06-01

    In preterm infants, nasal continuous positive airway pressure (NCPAP) is widely used for treatment of respiratory distress syndrome. However, the strategies for successfully weaning infants off NCPAP are still not well defined and there remains considerable variation between the methods. The objective of this study is to determine whether gradual weaning of NCPAP pressure is more successful than sudden weaning off NCPAP to room air. A randomized controlled trial was conducted in a level 3 neonatal intensive care unit on 70 preterm neonates who were born between 26 and 32 weeks gestation and required NCPAP for at least 48 h. When infants were stable on NCPAP at 0.21 FiO 2 and 5 cm H 2 O positive end expiratory pressure, neonates were randomized to the gradual wean group (reduction in pressure by 1 cm every 8 h until 3 cm H 2 0 was reached) or to sudden wean group (one time NCPAP removal to room air). The primary outcome was a success at the first trial to wean to room air. Secondary outcomes were a number of trials, and weight and postmenstrual age (PMA) at the time of successful wean. Total number of days on NCPAP and length of stay (LOS) in the hospital were also compared between the groups. Of the 70 infants included in the study, 35 were randomized to sudden group and 33 infants to gradual group (2 excluded for protocol deviation). In sudden and gradual groups, 14 and 22 infants, respectively, were weaned successfully in the first attempt (P=0.03). The infants were successfully weaned at 32.7±1.7 weeks versus 33.1±2.4 weeks (P=0.39) PMA and at a weight of 1651±290 g versus 1589±398 g (P=0.46) in the sudden and gradual groups, respectively. The total number of days on NCPAP was 27±19 days versus 32±24 days (P=0.38) and LOS was 63±25 days versus 63±22 days (P=0.99) in the sudden and gradual groups, respectively. Gradual weaning method was more successful as compared to sudden weaning method in the initial trial off NCPAP. There was no

  13. On some steady-state characteristics of systems with gradual repair

    International Nuclear Information System (INIS)

    Finkelstein, Maxim; Ludick, Zani

    2014-01-01

    We consider a repairable system with continuous output that alternates between states of operation and repair. The output of the system in the operating state is represented by a continuous, decreasing function of time. We assume that during the repair state, the system can produce output that is modelled by an increasing stochastic process. The repair action gradually restores the output of the system to its initial level and it returns to the operating state. We obtain and analyse expressions for the generalized availability and related characteristics of systems with gradual repair and consider several meaningful examples

  14. Different strategy of hand choice after learning of constant and incremental dynamical perturbation in arm reaching

    Directory of Open Access Journals (Sweden)

    Chie eHabagishi

    2014-02-01

    Full Text Available In daily life, we encounter situations where we must quickly decide which hand to use for a motor action. Here, we investigated whether the hand chosen for a motor action varied over a short timescale (i.e., hours with changes in arm dynamics. Participants performed a reaching task in which they moved a specified hand to reach a target on a virtual reality display. During the task, a resistive viscous force field was abruptly applied to only the dominant hand. To evaluate changes in hand choice caused by this perturbation, participants performed an interleaved choice test in which they could freely choose either hand for reaching. Furthermore, to investigate the effect of temporal changes on arm dynamics and hand choice, we exposed the same participants to another condition in which the force field was introduced gradually. When the abrupt force was applied, use of the perturbed hand significantly decreased and not changed during the training. In contrast, when the incremental force was applied, use of the perturbed hand gradually decreased as force increased. Surprisingly, even though the final amount of force was identical between the two conditions, hand choice was significantly biased toward the unperturbed hand in the gradual condition. These results suggest that time-varying changes in arm dynamics may have a greater influence on hand choice than the amplitude of the resistant force itself.

  15. A born global’s radical, gradual and nonlinear internationalization

    DEFF Research Database (Denmark)

    Vissak, Tiia; Zhang, Xiaotian

    2016-01-01

    a case of a Belarusian door producer that has invested to seven and exported to 11 more countries, we conclude that a home country’s political, economic environment can be a crucial ‘push’ factor for a firm’s fast internationalization but, thereafter, it can internationalize gradually due to lacking...... knowledge or other resources, and de-and re-internationalize due to various internal and, or external reasons. © Rainer Hampp Verlag....

  16. Gradualism in Tax Treaties with Irreversible Foreign Direct Investment

    OpenAIRE

    Richard Chisik; Ronald B. Davies

    2010-01-01

    Bilateral international tax treaties govern the host country taxation for the vast majority of the world’s foreign direct investment (FDI). Of particular interest is the fact that the tax rates used under these treaties are gradually falling although the treaties themselves do not specify any such reductions. Since there is no outside governing agency to redress treaty violations, such reductions must be both mutually beneficial and self-enforcing. Furthermore, the optimal tax rates must be l...

  17. Adaptation of the white shrimp Litopenaeus vannamei to gradual changes to a low-pH environment.

    Science.gov (United States)

    Han, Si-Yin; Wang, Bao-Jie; Liu, Mei; Wang, Meng-Qiang; Jiang, Ke-Yong; Liu, Xin-Wei; Wang, Lei

    2018-03-01

    pH variation could cause a stress response in euryhaline penaeids, we evaluated the mortality, growth performance, osmoregulation gene expression, digestive enzyme activity, histology, and resistance against Vibrio parahemolyticus of white shrimp Litopenaeus vannamei reared under conditions of gradual changes to a low-pH environment (gradual-low pH, 6.65-8.20) or a high-pH environment (gradual-high pH, 8.20-9.81) versus a normal pH environment (8.14-8.31) during a 28-d experiment. Consequently, under gradual-high pH, the cumulative mortality rate (CMR) rose with time until 39.9% on days 28; the weight gain percentage (WGP) and length gain percentage (LGP) decreased continuously. However, under gradual-low pH, the CMR of shrimp stabilized at 6.67% during 7-28 d; the WGP and LGP decreased first and then returned to normal. These results indicated that L. vannamei displayed a moderate tolerance to gradual-low pH, compared with gradual-high pH. Under gradual-low pH, the Na + /K + -ATPase, cytoplasmic carbonic anydrase (CAc), and glycosyl-phosphatidylinositol-linked carbonic anhydrase (CAg) transcripts of shrimp increased continuously or then back to normal; the amylase, lipase, and trypsin activities decreased first and then returned to normal or increased; the hepatopancreases and midguts showed histopathological lesions first and then got remission. Thus, the major adaptation mechanism of shrimp to gradual-low pH might be its high osmoregulation ability, which made shrimp achieve a new, balanced steady-state, then promoted longer intestinal villi and recuperative hepatopancreases of shrimp with enhanced digestive enzyme activities to increase nutrient absorption after long-term exposure. Meanwhile, the enhanced resistance against V. parahemolyticus under gradual-low pH would probably inhibit disease outbreak in the shrimp farming. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Cerebral Activations Related to Ballistic, Stepwise Interrupted and Gradually Modulated Movements in Parkinson Patients

    Science.gov (United States)

    Toxopeus, Carolien M.; Maurits, Natasha M.; Valsan, Gopal; Conway, Bernard A.; Leenders, Klaus L.; de Jong, Bauke M.

    2012-01-01

    Patients with Parkinson’s disease (PD) experience impaired initiation and inhibition of movements such as difficulty to start/stop walking. At single-joint level this is accompanied by reduced inhibition of antagonist muscle activity. While normal basal ganglia (BG) contributions to motor control include selecting appropriate muscles by inhibiting others, it is unclear how PD-related changes in BG function cause impaired movement initiation and inhibition at single-joint level. To further elucidate these changes we studied 4 right-hand movement tasks with fMRI, by dissociating activations related to abrupt movement initiation, inhibition and gradual movement modulation. Initiation and inhibition were inferred from ballistic and stepwise interrupted movement, respectively, while smooth wrist circumduction enabled the assessment of gradually modulated movement. Task-related activations were compared between PD patients (N = 12) and healthy subjects (N = 18). In healthy subjects, movement initiation was characterized by antero-ventral striatum, substantia nigra (SN) and premotor activations while inhibition was dominated by subthalamic nucleus (STN) and pallidal activations, in line with the known role of these areas in simple movement. Gradual movement mainly involved antero-dorsal putamen and pallidum. Compared to healthy subjects, patients showed reduced striatal/SN and increased pallidal activation for initiation, whereas for inhibition STN activation was reduced and striatal-thalamo-cortical activation increased. For gradual movement patients showed reduced pallidal and increased thalamo-cortical activation. We conclude that PD-related changes during movement initiation fit the (rather static) model of alterations in direct and indirect BG pathways. Reduced STN activation and regional cortical increased activation in PD during inhibition and gradual movement modulation are better explained by a dynamic model that also takes into account enhanced

  19. Cerebral activations related to ballistic, stepwise interrupted and gradually modulated movements in Parkinson patients.

    Directory of Open Access Journals (Sweden)

    Carolien M Toxopeus

    Full Text Available Patients with Parkinson's disease (PD experience impaired initiation and inhibition of movements such as difficulty to start/stop walking. At single-joint level this is accompanied by reduced inhibition of antagonist muscle activity. While normal basal ganglia (BG contributions to motor control include selecting appropriate muscles by inhibiting others, it is unclear how PD-related changes in BG function cause impaired movement initiation and inhibition at single-joint level. To further elucidate these changes we studied 4 right-hand movement tasks with fMRI, by dissociating activations related to abrupt movement initiation, inhibition and gradual movement modulation. Initiation and inhibition were inferred from ballistic and stepwise interrupted movement, respectively, while smooth wrist circumduction enabled the assessment of gradually modulated movement. Task-related activations were compared between PD patients (N = 12 and healthy subjects (N = 18. In healthy subjects, movement initiation was characterized by antero-ventral striatum, substantia nigra (SN and premotor activations while inhibition was dominated by subthalamic nucleus (STN and pallidal activations, in line with the known role of these areas in simple movement. Gradual movement mainly involved antero-dorsal putamen and pallidum. Compared to healthy subjects, patients showed reduced striatal/SN and increased pallidal activation for initiation, whereas for inhibition STN activation was reduced and striatal-thalamo-cortical activation increased. For gradual movement patients showed reduced pallidal and increased thalamo-cortical activation. We conclude that PD-related changes during movement initiation fit the (rather static model of alterations in direct and indirect BG pathways. Reduced STN activation and regional cortical increased activation in PD during inhibition and gradual movement modulation are better explained by a dynamic model that also takes into account

  20. Germany: of the nuclear energy expansion to the structure for their gradual abandonment; Alemania: de la expansion de la energia nuclear a la estructura para su abandono gradual

    Energy Technology Data Exchange (ETDEWEB)

    Mez, L. [Frei Universitat Berlin, Environmental Policy Research Centre, Thielallee 47, 14195 Berlin (Germany)

    2009-07-01

    This work exposes a panorama of the German nuclear industry, where the investment in this sector began around the fifty, having great peak during the period 1968 at 1989. Causes like a poor electricity demand, the over capacity and a persistent controversy among the public opinion for the nuclear energy use, stop the expansion from this industry to the little time of established. In contrast with the legal situation in most of the countries, in Germany the operation licences were granted without it limits of time. Nevertheless, the operation expectation was estimated inside a range of 20 to 40 years, depending in particular on the service life of the renovation parts. Taking into account these data, seven nuclear power plants of those that have already operated for 20 years or more, are about to confront expensive reconstructions or the closing in the following five years; while other seven will be closed in the subsequent 10 or 15 years. While the federal politicians and their directive went favorable until recent time in general to the extended use of nuclear energy, some authorities of the states became more restrictive when interpreting the allowed forecasts, what has generated continuous differences and regulatory uncertainty. In consequence, the facilities in operation gradually have shown interest in reaching agreements with the government about the nuclear politics, by means of the regulations reestablishment and one calculus linked at the costs. In spite of the many and constant judgments of the public opinion, the federal nuclear politics was up to 1998 on the side of the alliance pro nuclear and back to the industry by means of multiple fiscal and regulatory privileges. This official position was reverted by first time after the federal elections of that year, when a new red-green federal government announcement the gradual retirement of the nuclear energy of Germany. That coalition pact among the Democratic Social parties (red) and green

  1. Evaluation of community-level interventions to increase early initiation of antenatal care in pregnancy: protocol for the Community REACH study, a cluster randomised controlled trial with integrated process and economic evaluations.

    Science.gov (United States)

    Sawtell, Mary; Sweeney, Lorna; Wiggins, Meg; Salisbury, Cathryn; Eldridge, Sandra; Greenberg, Lauren; Hunter, Rachael; Kaur, Inderjeet; McCourt, Christine; Hatherall, Bethan; Findlay, Gail; Morris, Joanne; Reading, Sandra; Renton, Adrian; Adekoya, Ruth; Green, Belinda; Harvey, Belinda; Latham, Sarah; Patel, Kanta; Vanlessen, Logan; Harden, Angela

    2018-03-05

    The provision of high-quality maternity services is a priority for reducing inequalities in health outcomes for mothers and infants. Best practice includes women having their initial antenatal appointment within the first trimester of pregnancy in order to provide screening and support for healthy lifestyles, well-being and self-care in pregnancy. Previous research has identified inequalities in access to antenatal care, yet there is little evidence on interventions to improve early initiation of antenatal care. The Community REACH trial will assess the effectiveness and cost-effectiveness of engaging communities in the co-production and delivery of an intervention that addresses this issue. The study design is a matched cluster randomised controlled trial with integrated process and economic evaluations. The unit of randomisation is electoral ward. The intervention will be delivered in 10 wards; 10 comparator wards will have normal practice. The primary outcome is the proportion of pregnant women attending their antenatal booking appointment by the 12th completed week of pregnancy. This and a number of secondary outcomes will be assessed for cohorts of women (n = approximately 1450 per arm) who give birth 2-7 and 8-13 months after intervention delivery completion in the included wards, using routinely collected maternity data. Eight hospitals commissioned to provide maternity services in six NHS trusts in north and east London and Essex have been recruited to the study. These trusts will provide anonymised routine data for randomisation and outcomes analysis. The process evaluation will examine intervention implementation, acceptability, reach and possible causal pathways. The economic evaluation will use a cost-consequences analysis and decision model to evaluate the intervention. Targeted community engagement in the research process was a priority. Community REACH aims to increase early initiation of antenatal care using an intervention that is co-produced and

  2. Reaching the unreached.

    Science.gov (United States)

    Ariyaratne, A T

    1989-01-01

    Embodied in the child survival revolution are ideological, methodological, and organizational innovations aimed at radical change in the condition of the world's children as rapidly as possible. In countries such as Sri Lanka, child survival and health for all by the year 2000 often seem to be impossible goals, given the tumultuous socioeconomic and political conditions. In Sri Lanka, the quality of life has been eroded, not enhanced, by the importation of Western technology and managerial capitalism and the destruction of indigenous processes. The chaos and violence that have been brought into the country have made it difficult to reach the poor children, women, and refugees in rural areas with primary health care interventions. Sri Lanka's unreachable--the decision making elites--have blocked access to the unreached--the urban and rural poor. If governments are to reach the unreached, they must remove the obstacles to a people-centered, community development process. It is the people themselves, and the institutions of their creation, that can reach the children amidst them in greatest need. To achieve this task, local communities must be provided with basic human rights, the power to make decisions that affect their lives, necessary resources, and appropriate technologies. Nongovernmental organizations can play a crucial role as bridges between the unreached and the unreachable by promoting community empowerment, aiding in the formation of networks of community organizations, and establishing linkages with government programs. If the ruling elites in developing countries can be persuaded to accommodate the needs and aspirations of those who, to date, have been excluded from the development process, the child survival revolution can be a nonviolent one.

  3. Is synaesthesia really stable – or does it gradually consolidate?

    DEFF Research Database (Denmark)

    Sørensen, Thomas Alrik

    Synaesthesia is a condition describing a perceptual variation where experience an additional concurrent following an inducer stimulus (Grossenbacher & Lovelace, 2001); some may experience that weekdays or letters have a specific colour, or that a number has a certain size or relate to a particular...... is that the associations are stable over time. However, here we present the case of AR, a colour-grapheme synaesthete who clearly demonstrate synaesthesia, but also a gradual consolidation over time (Sørensen, Nordfang, & Ásgeirsson, accepted). Also, AR does not demonstrate some of the typical modulations of attention...

  4. LONG DURATION FLARE EMISSION: IMPULSIVE HEATING OR GRADUAL HEATING?

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, Jiong; Longcope, Dana W. [Department of Physics, Montana State University, Bozeman MT 59717-3840 (United States)

    2016-03-20

    Flare emissions in X-ray and EUV wavelengths have previously been modeled as the plasma response to impulsive heating from magnetic reconnection. Some flares exhibit gradually evolving X-ray and EUV light curves, which are believed to result from superposition of an extended sequence of impulsive heating events occurring in different adjacent loops or even unresolved threads within each loop. In this paper, we apply this approach to a long duration two-ribbon flare SOL2011-09-13T22 observed by the Atmosphere Imaging Assembly (AIA). We find that to reconcile with observed signatures of flare emission in multiple EUV wavelengths, each thread should be heated in two phases, an intense impulsive heating followed by a gradual, low-rate heating tail that is attenuated over 20–30 minutes. Each AIA resolved single loop may be composed of several such threads. The two-phase heating scenario is supported by modeling with both a zero-dimensional and a 1D hydrodynamic code. We discuss viable physical mechanisms for the two-phase heating in a post-reconnection thread.

  5. Gradual approach to refinement of the nasal tip: surgical results

    Directory of Open Access Journals (Sweden)

    Thiago Bittencourt Ottoni de Carvalho

    2015-02-01

    Full Text Available Introduction: The complexity of the nasal tip structures and the impact of surgical maneuvers make the prediction of the final outcome very difficult. Therefore, no single technique is enough to correct the several anatomical presentations, and adequate preoperative planning represents the basis of rhinoplasty. Objective: To present results of rhinoplasty, through the gradual surgical approach to nasal tip definition based on anatomical features, and to evaluate the degree of patient satisfaction after the surgical procedure. Methods: Longitudinal retrospective cohort study of the medical charts of 533 patients of both genders who underwent rhinoplasty from January of 2005 to January of 2012 was performed. Cases were allocated into seven groups: (1 no surgery on nasal tip; (2 interdomal breakup; (3 cephalic trim; (4 domal suture; (5 shield-shaped graft; (6 vertical dome division; (7 replacement of lower lateral cartilages. Results: Group 4 was the most prevalent. The satisfaction rate was 96% and revision surgery occurred in 4% of cases. Conclusion: The protocol used allowed the implementation of a gradual surgical approach to nasal tip definition with the nasal anatomical characteristics, high rate of patient satisfaction with the surgical outcome, and low rate of revision.

  6. Feasibility of computerized scheduled gradual reduction for adolescent smoking cessation.

    Science.gov (United States)

    Riley, William; Jerome, Albert; Behar, Albert; Zack, Sharon

    2002-01-01

    The purpose of this project was to modify a smoking cessation program that uses computerized scheduled gradual reduction for use with adolescent smokers and to test the feasibility of this cessation approach in group support and minimal contact modalities. Utilizing a lesson plan approach with high school marketing students in five high schools and student survey feedback, the LifeSign program was modified to be an acceptable smoking cessation program for adolescent smokers. In the first study, 17 adolescent smokers used the modified program with seven associated weekly group support sessions. At the end of treatment, 29% had quit smoking, and over half of those who continued to smoke reduced their smoking rate by 50%. In the second study, the LifeSign for Teens program was evaluated with 18 adolescent smokers in a minimal contact format. At the end of treatment, 17% had quit smoking, and mean smoking rate reductions of 43% were found among those who continued smoking. At 1-year follow-up, all subjects who had quit at posttreatment reported continuous abstinence. The results of these two small trials suggest that a computerized scheduled gradual reduction approach may be an accepted and potentially efficacious approach for smoking cessation among adolescent smokers.

  7. Effects of Experimental High Flow Releases and Increased Fluctuations in Flow from Glen Canyon Dam on Abundance, Growth, and Survival Rates of Early Life Stages of Rainbow Trout in the Lee's Ferry Reach of the Colorado River

    Science.gov (United States)

    Korman, Josh

    2010-05-01

    The abundance of adult fish populations is controlled by the growth and survival rates of early life stages. Evaluating the effects of flow regimes on early life stages is therefore critical to determine how these regimes affect the abundance of adult populations. Experimental high flow releases from Glen Canyon Dam, primarily intended to conserve fine sediment and improve habitat conditions for native fish in the Colorado River in Grand Canyon, AZ, have been conducted in 1996, 2004, and 2008. These flows potentially affect the Lee's Ferry reach rainbow trout population, located immediately downstream of the dam, which supports a highly valued fishery and likely influences the abundance of rainbow trout in Grand Canyon. Due to concerns about negative effects of high trout abundance on endangered native fish, hourly variation in flow from Glen Canyon Dam was experimentally increased between 2003 and 2005 to reduce trout abundance. This study reports on the effects of experimental high flow releases and fluctuating flows on early life stages of rainbow trout in the Lee's Ferry reach based on monthly sampling of redds (egg nests) and the abundance and growth of age-0 trout between 2003 and 2009. Data on spawn timing, spawning elevations, and intergravel temperatures were integrated in a model to estimate the magnitude and seasonal trend in incubation mortality resulting from redd dewatering due to fluctuations in flow. Experimental fluctuations from January through March promoted spawning at higher elevations where the duration of dewatering was longer and intergravel temperatures exceeded lethal thresholds. Flow-dependent incubation mortality rates were 24% (2003) and 50% (2004) in years with higher flow fluctuations, compared to 5-11% under normal operations (2006-2009). Spatial and temporal predictions of mortality were consistent with direct observations of egg mortality determined from the excavation of 125 redds. The amount of variation in backcalculated hatch

  8. Designing a gradual transition to a hydrogen economy in Spain

    Science.gov (United States)

    Brey, J. J.; Brey, R.; Carazo, A. F.; Contreras, I.; Hernández-Díaz, A. G.; Gallardo, V.

    The lack of sustainability of the current Spanish energy system makes it necessary to study the adoption of alternative energy models. One of these is what is known as the hydrogen economy. In this paper, we aim to plan, for the case of Spain, an initial phase for transition to this energy model making use of the potential offered by each Spanish region. Specifically, the target pursued is to satisfy at least 15% of energy demand for transport by 2010 through renewable sources. We plan to attain this target gradually, establishing intermediate stages consisting of supplying 5 and 10% of the energy demand for transport by 2006 and 2008, respectively. The results obtained allow us to determine, for each region, the hydrogen production and consumption, the renewable energy sources used to obtain hydrogen and the transport requirements between regions.

  9. Principle of progressive (gradual use of contractual remedies

    Directory of Open Access Journals (Sweden)

    Bazil OGLINDĂ

    2014-12-01

    Full Text Available In this study, we intend to answer to the question whether, in the modern contract law, in general, and in Romanian contract law, in particular, the creditor may resort almost discretionary to remedies (contractual sanctions such as termination, rescission without being opposed that he should have resorted to other more appropriate remedies. In order to answer to this question, we find it extremely useful to define the term of contractual remedy and to analyse the correlation of this principle with other principles of modern contract law. Also, last but not least, we intend to define the principle of progressive (gradual use of the contractual remedies and to detail the vocation (legal nature of this principle in the modern contract law, having as starting point the provisions of the new Romanian Civil Code.

  10. High temperature deformation behavior of gradually pressurized zircaloy-4 tubes

    International Nuclear Information System (INIS)

    Suzuki, Motoye

    1982-03-01

    In order to obtain preliminary perspectives on fuel cladding deformation behavior under changing temperature and pressure conditions in a hypothetical loss-of-coolant accident of PWR, a Zircaloy-4 tube burst test was conducted in both air and 99.97% Ar atomospheres. The tubes were directly heated by AC-current and maintained at various temperatures, and pressurized gradually until rupture occurred. Rupture circumferential strains were generally larger in Ar gas than in air and attained a maximum around 1100 K in both atmospheres. Some tube tested in air produced axially-extended long balloons, which proved not to be explained by such properties or ideas as effect of cooling on strain rate, superplasticity, geometrical plastic instability and stresses generated by surface oxide layer. A cause of the long balloon may be obtained in the anisotropy of the material structure. But even a qualitative analysis based on this property can not be made due to insufficient data of the anisotropy. (author)

  11. Reaching Beyond The Stars

    Science.gov (United States)

    Baker, Mariah; Rosenthal, L.; Gaughan, A.; Hopkins, E.

    2014-01-01

    Strawbridge Observatory at Haverford College is home to a undergraduate-led public observing program. Our program holds ~once monthly public events throughout the academic year that take advantage of eyepiece observing on our 16-inch and 12-inch telescopes as well as of the classroom, library, and projection system. These resources allow us to organize a variety of astronomy related activities that are engaging for individuals of all ages: accessible student talks, current film screenings and even arts and crafts for the families who attend with young children. These events aim to spark curiosity in others about scientific discovery and about the remarkable nature of the world in which we live. In addition to exciting local families about astronomy, this program has excited Haverford students from a range of disciplines about both science and education. Being entirely student led means that we are able to take the initiative in planning, coordinating and running all events, fostering an atmosphere of collaboration, experimentation and commitment amongst our volunteers. Additionally, this program is one of the few at Haverford that regularly reaches beyond the campus walls to promote and build relationships with the outside community. In light of this, our program presents a distinctive and enlightening opportunity for student volunteers: we get to use our scientific backgrounds to educate a general audience, while also learning from them about how to communicate and inspire in others the excitement we feel about the subject of astronomy. The work on this project has been supported by NSF AST-1151462.

  12. GAP-REACH

    Science.gov (United States)

    Lewis-Fernández, Roberto; Raggio, Greer A.; Gorritz, Magdaliz; Duan, Naihua; Marcus, Sue; Cabassa, Leopoldo J.; Humensky, Jennifer; Becker, Anne E.; Alarcón, Renato D.; Oquendo, María A.; Hansen, Helena; Like, Robert C.; Weiss, Mitchell; Desai, Prakash N.; Jacobsen, Frederick M.; Foulks, Edward F.; Primm, Annelle; Lu, Francis; Kopelowicz, Alex; Hinton, Ladson; Hinton, Devon E.

    2015-01-01

    Growing awareness of health and health care disparities highlights the importance of including information about race, ethnicity, and culture (REC) in health research. Reporting of REC factors in research publications, however, is notoriously imprecise and unsystematic. This article describes the development of a checklist to assess the comprehensiveness and the applicability of REC factor reporting in psychiatric research publications. The 16-itemGAP-REACH© checklist was developed through a rigorous process of expert consensus, empirical content analysis in a sample of publications (N = 1205), and interrater reliability (IRR) assessment (N = 30). The items assess each section in the conventional structure of a health research article. Data from the assessment may be considered on an item-by-item basis or as a total score ranging from 0% to 100%. The final checklist has excellent IRR (κ = 0.91). The GAP-REACH may be used by multiple research stakeholders to assess the scope of REC reporting in a research article. PMID:24080673

  13. UX-15 Reaches LEP

    CERN Multimedia

    2001-01-01

    The creation of the world's largest sandstone cavern, not a small feat! At the bottom, cave-in preventing steel mesh can be seen clinging to the top of the tunnel. The digging of UX-15, the cavern that will house ATLAS, reached the upper ceiling of LEP on October 10th. The breakthrough which took place nearly 100 metres underground occurred precisely on schedule and exactly as planned. But much caution was taken beforehand to make the LEP breakthrough clean and safe. To prevent the possibility of cave-ins in the side tunnels that will eventually be attached to the completed UX-15 cavern, reinforcing steel mesh was fixed into the walls with bolts. Obviously no people were allowed in the LEP tunnels below UX-15 as the breakthrough occurred. The area was completely evacuated and fences were put into place to keep all personnel out. However, while personnel were being kept out of the tunnels below, this has been anything but the case for the work taking place up above. With the creation of the world's largest...

  14. Interacting Learning Processes during Skill Acquisition: Learning to control with gradually changing system dynamics.

    Science.gov (United States)

    Ludolph, Nicolas; Giese, Martin A; Ilg, Winfried

    2017-10-16

    There is increasing evidence that sensorimotor learning under real-life conditions relies on a composition of several learning processes. Nevertheless, most studies examine learning behaviour in relation to one specific learning mechanism. In this study, we examined the interaction between reward-based skill acquisition and motor adaptation to changes of object dynamics. Thirty healthy subjects, split into two groups, acquired the skill of balancing a pole on a cart in virtual reality. In one group, we gradually increased the gravity, making the task easier in the beginning and more difficult towards the end. In the second group, subjects had to acquire the skill on the maximum, most difficult gravity level. We hypothesized that the gradual increase in gravity during skill acquisition supports learning despite the necessary adjustments to changes in cart-pole dynamics. We found that the gradual group benefits from the slow increment, although overall improvement was interrupted by the changes in gravity and resulting system dynamics, which caused short-term degradations in performance and timing of actions. In conclusion, our results deliver evidence for an interaction of reward-based skill acquisition and motor adaptation processes, which indicates the importance of both processes for the development of optimized skill acquisition schedules.

  15. Gradually varied flow in compound open channels; Flujo gradualmente variado en canales de seccion compuesta

    Energy Technology Data Exchange (ETDEWEB)

    Sotela Avila, Gilberto [Universidad Nacional Autonoma de Mexico (Mexico)

    2001-03-01

    The author shows that the computation of gradually-varied-flow profiles in prismatic compound channels involves the solution of the dynamic equation, but using the compound channel Froude number defined by Blalock and Sturm. The same equation is used for non-prismatic channels by dividing the channel into short reaches and carrying the computation step by step through an iterative process. [Spanish] El autor demuestra que los perfiles del flujo gradualmente variado en canales prismaticos de seccion compuesta se pueden determinar mediante la integracion de la llamada ecuacion dinamica, pero usando el numero de Froude definido por Blalock y Sturm para este tipo de canales. Cuando no son prismaticos, tambien se aplica la ecuacion de la energia por tramos y el calculo sigue un proceso iterativo una vez definidos los tirantes criticos multiples y la zona en que se desarrolla el perfil.

  16. Adaptation of reach-to-grasp movement in response to force perturbations.

    Science.gov (United States)

    Rand, M K; Shimansky, Y; Stelmach, G E; Bloedel, J R

    2004-01-01

    This study examined how reach-to-grasp movements are modified during adaptation to external force perturbations applied on the arm during reach. Specifically, we examined whether the organization of these movements was dependent upon the condition under which the perturbation was applied. In response to an auditory signal, all subjects were asked to reach for a vertical dowel, grasp it between the index finger and thumb, and lift it a short distance off the table. The subjects were instructed to do the task as fast as possible. The perturbation was an elastic load acting on the wrist at an angle of 105 deg lateral to the reaching direction. The condition was modified by changing the predictability with which the perturbation was applied in a given trial. After recording unperturbed control trials, perturbations were applied first on successive trials (predictable perturbations) and then were applied randomly (unpredictable perturbations). In the early predictable perturbation trials, reach path length became longer and reaching duration increased. As more predictable perturbations were applied, the reach path length gradually decreased and became similar to that of control trials. Reaching duration also decreased gradually as the subjects adapted by exerting force against the perturbation. In addition, the amplitude of peak grip aperture during arm transport initially increased in response to repeated perturbations. During the course of learning, it reached its maximum and thereafter slightly decreased. However, it did not return to the normal level. The subjects also adapted to the unpredictable perturbations through changes in both arm transport and grasping components, indicating that they can compensate even when the occurrence of the perturbation cannot be predicted during the inter-trial interval. Throughout random perturbation trials, large grip aperture values were observed, suggesting that a conservative aperture level is set regardless of whether the

  17. Use of radiation processing technology gradually expands in industry

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    The use of radioisotopes and radiation is expanding in the fields of industries and medicine with a high potentiality of the application to environmental protection. The technology transfer on the use of isotopes and radiation is progressing in the framework of international cooperation. But the industry has maintained wait and see attitude on the commercialization of food irradiation. Such present features were the highlight in the 19th Japan Conference on Radiation and Radioisotopes held on November 14-16. 72 papers from 19 countries were presented and discussed in 13 sessions. The progress of accelerator technology has contributed to the expansion of radiation processing market. The importance of the application of isotopes and radiation to environmental protection has been gradually acknowledged, and the electron beam treatment of flue gas for acid rain abatement and the elimination of chlorinated ethylene from drinking water were discussed. Drastic change has not been seen in the climate of food irradiation, however there are several positive indicators which support the prediction of slow but steady progress in the commercialization of the process and the trade of irradiated foods. (K.I.)

  18. Impact of a gradual increase in milk quotas on the EU dairy sector

    NARCIS (Netherlands)

    Bouamra-Mechemache, Z.; Jongeneel, R.; Requillart, V.

    2008-01-01

    The European Union (EU) dairy sector is facing significant changes due to EU enlargement, the Luxembourg reform and ongoing World Trade Organisation (WTO) negotiations. This paper explores the impact of alternative dairy policies in the context of a WTO agreement and further dairy policy

  19. Germany: of the nuclear energy expansion to the structure for their gradual abandonment

    International Nuclear Information System (INIS)

    Mez, L.

    2009-01-01

    This work exposes a panorama of the German nuclear industry, where the investment in this sector began around the fifty, having great peak during the period 1968 at 1989. Causes like a poor electricity demand, the over capacity and a persistent controversy among the public opinion for the nuclear energy use, stop the expansion from this industry to the little time of established. In contrast with the legal situation in most of the countries, in Germany the operation licences were granted without it limits of time. Nevertheless, the operation expectation was estimated inside a range of 20 to 40 years, depending in particular on the service life of the renovation parts. Taking into account these data, seven nuclear power plants of those that have already operated for 20 years or more, are about to confront expensive reconstructions or the closing in the following five years; while other seven will be closed in the subsequent 10 or 15 years. While the federal politicians and their directive went favorable until recent time in general to the extended use of nuclear energy, some authorities of the states became more restrictive when interpreting the allowed forecasts, what has generated continuous differences and regulatory uncertainty. In consequence, the facilities in operation gradually have shown interest in reaching agreements with the government about the nuclear politics, by means of the regulations reestablishment and one calculus linked at the costs. In spite of the many and constant judgments of the public opinion, the federal nuclear politics was up to 1998 on the side of the alliance pro nuclear and back to the industry by means of multiple fiscal and regulatory privileges. This official position was reverted by first time after the federal elections of that year, when a new red-green federal government announcement the gradual retirement of the nuclear energy of Germany. That coalition pact among the Democratic Social parties (red) and green

  20. Molecular sieving action of the cell membrane during gradual osmotic hemolysis

    Energy Technology Data Exchange (ETDEWEB)

    MacGregor, R.D. II

    1977-05-01

    Rat erythrocytes were hemolyzed by controlled gradual osmotic hemolysis to study cell morphology and hemoglobin loss from individual cells. Results suggest that each increase in the rate of loss of a protein from the cells during the initial phases of controlled gradual osmotic hemolysis is caused by the passage of a previously impermeable species across the stressed membrane. Similarly, during the final stages of controlled gradual osmotic hemolysis, each sharp decrease in the rate of loss of a protein corresponds to the termination of a molecular flow. A theoretical model is described that predicts the molecular sieving of soluble globular proteins across the stressed red cell membrane. Hydrophobic interactions occur between the soluble proteins and the lipid bilayer portion of the cell membrane. A spectrin network subdivides the bilayer into domains that restrict the insertion of large molecules into the membrane. Other membrane proteins affect soluble protein access to the membrane. Changes in the loss curves caused by incubation of red cells are discussed in terms of the model.

  1. Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Carolien M Toxopeus

    Full Text Available Purposeful movements are attained by gradually adjusted activity of opposite muscles, or synergists. This requires a motor system that adequately modulates initiation and inhibition of movement and selectively activates the appropriate muscles. In patients with Parkinson's disease (PD initiation and inhibition of movements are impaired which may manifest itself in e.g. difficulty to start and stop walking. At single-joint level, impaired movement initiation is further accompanied by insufficient inhibition of antagonist muscle activity. As the motor symptoms in PD primarily result from cerebral dysfunction, quantitative investigation of gradually adjusted muscle activity during execution of purposeful movement is a first step to gain more insight in the link between impaired modulation of initiation and inhibition at the levels of (i cerebrally coded task performance and (ii final execution by the musculoskeletal system. To that end, the present study investigated changes in gradual adjustment of muscle synergists using a manipulandum that enabled standardized smooth movement by continuous wrist circumduction. Differences between PD patients (N = 15, off-medication and healthy subjects (N = 16 concerning the relation between muscle activity and movement performance in these groups were assessed using kinematic and electromyographic (EMG recordings. The variability in the extent to which a particular muscle was active during wrist circumduction--defined as muscle activity differentiation--was quantified by EMG. We demonstrated that more differentiated muscle activity indeed correlated positively with improved movement performance, i.e. higher movement speed and increased smoothness of movement. Additionally, patients employed a less differentiated muscle activity pattern than healthy subjects. These specific changes during wrist circumduction imply that patients have a decreased ability to gradually adjust muscles causing a decline in

  2. Policy Analysis Reaches Midlife

    Directory of Open Access Journals (Sweden)

    Beryl A. Radin

    2013-07-01

    Full Text Available The field of policy analysis that exists in the 21st century is quite different from that found earlier phases. The world of the 1960s that gave rise to this field in the US often seems unrelated to the world we experience today. These shifts have occurred as a result of a range of developments – technological changes, changes in the structure and processes of government both internally and globally, new expectations about accountability and transparency, economic and fiscal problems, and increased political and ideological conflict.It is clear globalization has had a significant impact on the field. Shifts in the type of decisionmaking also have created challenges for policy analysts since analysts are now clearly in every nook and cranny in the decisionmaking world. Thus it is relevant to look at the work that they do, the skills that they require, and the background experience that is relevant to them.

  3. Conservation reaches new heights.

    Science.gov (United States)

    Pepall, J; Khanal, P

    1992-10-01

    The conservation program with the management assistance of the Woodlands Mountain Institute in 2 contiguous parks, the Mount Everest National Park in Nepal and the Qomolangma Nature Reserve in China, in 2 countries is described. The focus is on conservation of the complex ecosystem with sustainable development by showing local people how to benefit from the park without environmental damage. Cultural diversity is as important as biological diversity. The area has been designated by UNESCO as a World Heritage Site with the "last pure ecological seed" of the Himalayas. The regional geography and culture are presented. Population growth has impacted natural resources through overgrazing, cultivation of marginal land, and deforestation; future plans to build a dam and road bordering the nature reserve pose other threats. Proposed management plans for the Makalu-Barun Nature Park (established in November 1991) and Conservation Area include a division of the park into nature reserve areas free of human activity, protected areas which permit traditional land use, and special sites and trail for tourists and religious pilgrims. The conservation area will act as a buffer for the park and provide economic opportunities; further subdivisions include land use for biodiversity protection, community forest and pasture, agroforestry, and agriculture and settlement. Efforts will be made to increase the welfare of women and local people; proposed projects include the introduction of higher milk-producing animals for stall feeding. Also proposed is a cultural and natural history museum. 70% of the project's resources will be directed to local community participation in consultation and park maintenance. The project is a model of how conservation and protection of natural resources can coexist with local economic development and participation; an integration of preservation of biological diversity, mountain wisdom, and the value of local people as resources for conservation.

  4. Reach the sky

    Science.gov (United States)

    Mariana Peicuti, Cristina

    2017-04-01

    sun:make a gnomon pattern/Refer to the latitude table to determine the correct angle to mark- 45°/Place the sundial outdoors,with the gnomon pointing North/Record the outline of the gnomon's shadow and record the time next to it/Repeat this process each hour/See if the students notice a pattern in the movement of the shadow. ☼ Play Dough Planets-To demonstrate the size(volume)differences between Earth,Earth's Moon and Mars through a hands-on activity:Make a play dough ball about the size of a marble(Moon).How many "Moons" it would take to make a ball the size of the Mars or Earth?Students combine 8 of the Moon-size balls to make one "Mars"ball.The students have a Moon and a Mars and after that they combine 50 Moon-size balls,to make"Earth." By second to fourth grade age,students are increasingly able to think about abstractions and different perspectives.They can reflect on their thinking and can consider whether their reasoning follows well from the evidence that they have collected.knowledge.They will be learning that science is a continuing process of seeking answers. "We learn best when we learn from our own experiences."

  5. Gradual diffusive capture: slow death by many mosquito bites

    International Nuclear Information System (INIS)

    Redner, S; Bénichou, O

    2014-01-01

    We study the dynamics of a single diffusing particle (a ‘man’) with diffusivity D M that is attacked by another diffusing particle (a ‘mosquito’) with fixed diffusivity D m . Each time the mosquito meets and bites the man, the diffusivity of the man is reduced by a fixed amount, while the diffusivity of the mosquito is unchanged. The mosquito is also displaced by a small distance ±a with respect to the man after each encounter. The man is defined as dead when D M reaches zero. At the moment when the man dies, his probability distribution of displacements x is given by a Cauchy form, which asymptotically decays as x −2 , while the distribution of times t when the man dies decays asymptotically as t −3/2 , which has the same form as the one-dimensional first-passage probability. (paper)

  6. Gradual Incorporation of Whole Wheat Flour into Bread Products for Elementary School Children Improves Whole Grain Intake

    Science.gov (United States)

    Rosen, Renee A.; Sadeghi, Lelia; Schroeder, Natalia; Reicks, Marla M.; Marquart, Len

    2008-01-01

    Purpose: Whole grain intake is associated with health benefits but current consumption by children is only about one-third of the recommended level. The purpose of this study was to test the feasibility of an innovative approach whereby the whole wheat content of bread products in school lunches was gradually increased to increase whole grain…

  7. Electron–Ion Intensity Dropouts in Gradual Solar Energetic Particle Events during Solar Cycle 23

    International Nuclear Information System (INIS)

    Tan, Lun C.

    2017-01-01

    Since the field-line mixing model of Giacalone et al. suggests that ion dropouts cannot happen in the “gradual” solar energetic particle (SEP) event because of the large size of the particle source region in the event, the observational evidence of ion dropouts in the gradual SEP event should challenge the model. We have searched for the presence of ion dropouts in the gradual SEP event during solar cycle 23. From 10 SEP events the synchronized occurrence of ion and electron dropouts is identified in 12 periods. Our main observational facts, including the mean width of electron–ion dropout periods being consistent with the solar wind correlation scale, during the dropout period the dominance of the slab turbulence component and the enhanced turbulence power parallel to the mean magnetic field, and the ion gyroradius dependence of the edge steepness in dropout periods, are all in support of the solar wind turbulence origin of dropout events. Also, our observation indicates that a wide longitude distribution of SEP events could be due to the increase of slab turbulence fraction with the increased longitude distance from the flare-associated active region.

  8. Electron-Ion Intensity Dropouts in Gradual Solar Energetic Particle Events during Solar Cycle 23

    Science.gov (United States)

    Tan, Lun C.

    2017-09-01

    Since the field-line mixing model of Giacalone et al. suggests that ion dropouts cannot happen in the “gradual” solar energetic particle (SEP) event because of the large size of the particle source region in the event, the observational evidence of ion dropouts in the gradual SEP event should challenge the model. We have searched for the presence of ion dropouts in the gradual SEP event during solar cycle 23. From 10 SEP events the synchronized occurrence of ion and electron dropouts is identified in 12 periods. Our main observational facts, including the mean width of electron-ion dropout periods being consistent with the solar wind correlation scale, during the dropout period the dominance of the slab turbulence component and the enhanced turbulence power parallel to the mean magnetic field, and the ion gyroradius dependence of the edge steepness in dropout periods, are all in support of the solar wind turbulence origin of dropout events. Also, our observation indicates that a wide longitude distribution of SEP events could be due to the increase of slab turbulence fraction with the increased longitude distance from the flare-associated active region.

  9. Electron–Ion Intensity Dropouts in Gradual Solar Energetic Particle Events during Solar Cycle 23

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Lun C., E-mail: ltan@umd.edu [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States)

    2017-09-01

    Since the field-line mixing model of Giacalone et al. suggests that ion dropouts cannot happen in the “gradual” solar energetic particle (SEP) event because of the large size of the particle source region in the event, the observational evidence of ion dropouts in the gradual SEP event should challenge the model. We have searched for the presence of ion dropouts in the gradual SEP event during solar cycle 23. From 10 SEP events the synchronized occurrence of ion and electron dropouts is identified in 12 periods. Our main observational facts, including the mean width of electron–ion dropout periods being consistent with the solar wind correlation scale, during the dropout period the dominance of the slab turbulence component and the enhanced turbulence power parallel to the mean magnetic field, and the ion gyroradius dependence of the edge steepness in dropout periods, are all in support of the solar wind turbulence origin of dropout events. Also, our observation indicates that a wide longitude distribution of SEP events could be due to the increase of slab turbulence fraction with the increased longitude distance from the flare-associated active region.

  10. Natural gas prices and the end of gradual change

    International Nuclear Information System (INIS)

    Osten, J.A.

    1998-01-01

    Natural gas price predictions for the years 1998, 1999-2001, 2000-2005 are provided. In general, prices are predicted to decrease with increase in storage. Some other factors that will influence the price of natural gas and, therefore, should receive consideration in price predictions, include growth in demand, natural gas production, deliverability, new pipelines, and the Alberta price basis. tabs., figs

  11. Gradual Changes of Gut Microbiota in Weaned Miniature Piglets

    Directory of Open Access Journals (Sweden)

    Xianghua Yan

    2016-11-01

    Full Text Available Colonization of gut microbiota in mammals during the early life is vital to host health. The miniature piglet has recently been considered as an optimal infant model. However, less is known about the development of gut microbiota in miniature piglets. Here, this study was conducted to explore how the gut microbiota develops in weaned Congjiang miniature piglets. In contrast to the relatively stabilized gut fungal community, gut bacterial community showed a marked drop in alpha diversity, accompanied by significant alterations in taxonomic compositions. The relative abundances of 24 bacterial genera significantly declined, whereas the relative abundances of 7 bacterial genera (Fibrobacter, Collinsella, Roseburia, Prevotella, Dorea, Howardella, and Blautia significantly increased with the age of weaned piglets. Fungal taxonomic analysis showed that the relative abundances of 2 genera (Kazachstania and Aureobasidium significantly decreased, whereas the relative abundances of 4 genera (Aspergillus, Cladosporium, Simplicillium, and Candida significantly increased as the piglets aged. Kazachstania telluris was the signature species predominated in gut fungal communities of weaned miniature piglets. The functional maturation of the gut bacterial community was characterized by the significantly increased digestive system, glycan biosynthesis and metabolism, and vitamin B biosynthesis as the piglets aged. These findings suggest that marked gut microbial changes in Congjiang miniature piglets may contribute to understand the potential gut microbiota development of weaned infants.

  12. Influence of gradual density transition and nonlinear saturation on Rayleigh-Taylor instability growth

    International Nuclear Information System (INIS)

    Jacobs, H.

    1984-08-01

    Linear theory of Rayleigh-Taylor instability growth at a density profile which varies exponentially between regions of constant density is discussed in detail. The exact theory provides an approximate but conservative simple formula for the growth constant and it shows that a hitherto widely used theory erroneously underestimates the growth constant. A simple but effective ''synthetical model'' of nonlinear bubble growth is obtained from a synthesis of linear theory and constant terminal bubble speed. It is applied to pusher shell break-up in an inertial confinement fusion pellet to determine the maximum allowable initial perturbations and the most dangerous wavelength. In a situation typical of heavy ion drivers it is found that the allowable initial perturbations are increased by a few orders of magnitude by the gradual density transition and another order of magnitude by nonlinear saturation of the bubble speed. The gradual density transition also shifts the most dangerous wavelength from about once to about four times the minimum pusher shell thickness. The following topics are treated briefly: Reasons conflicting with use of the synthetical model to decide whether the pusher shell in a certain simulation will be broken up; other nonlinear theories available in the literature; further realistic effects that might aggravate instability growth. (orig.) [de

  13. Experimental test of Neel's theory of the Rayleigh rule using gradually devitrified Co-based glass

    International Nuclear Information System (INIS)

    Lachowicz, H.K.

    2000-01-01

    It is shown that gradually devitrified Co-based nonmagnetostrictive metallic glass is an excellent model material to verify Louis Neel's theory of the Rayleigh rule. In the course of the calculations, Neel showed that the parameter p=bH c /a (where H c is the coercivity, a and b are the coefficients of a quadratic polynomial expressing the Rayleigh rule) is expected to range between 0.6 (hard magnets) and 1.6 (soft). However, the experimental values of this parameter, reported in the literature for a number of mono- and poly-crystalline magnets, are much greater than those expected from the theory presented by Neel (in some cases even by two orders of magnitude). The measurements, performed for a series of Co-based metallic glass samples annealed at gradually increasing temperature to produce nanocrystalline structures with differentiated density and size of the crystallites, have shown that the calculated values of the parameter p fall within the range expected from Neel's theory

  14. Acoustic backscatter models of fish: Gradual or punctuated evolution

    Science.gov (United States)

    Horne, John K.

    2004-05-01

    Sound-scattering characteristics of aquatic organisms are routinely investigated using theoretical and numerical models. Development of the inverse approach by van Holliday and colleagues in the 1970s catalyzed the development and validation of backscatter models for fish and zooplankton. As the understanding of biological scattering properties increased, so did the number and computational sophistication of backscatter models. The complexity of data used to represent modeled organisms has also evolved in parallel to model development. Simple geometric shapes representing body components or the whole organism have been replaced by anatomically accurate representations derived from imaging sensors such as computer-aided tomography (CAT) scans. In contrast, Medwin and Clay (1998) recommend that fish and zooplankton should be described by simple theories and models, without acoustically superfluous extensions. Since van Holliday's early work, how has data and computational complexity influenced accuracy and precision of model predictions? How has the understanding of aquatic organism scattering properties increased? Significant steps in the history of model development will be identified and changes in model results will be characterized and compared. [Work supported by ONR and the Alaska Fisheries Science Center.

  15. Morphological adjustments in a meandering reach of the middle Yangtze River caused by severe human activities

    Science.gov (United States)

    Zhou, Meirong; Xia, Junqiang; Lu, Jinyou; Deng, Shanshan; Lin, Fenfen

    2017-05-01

    In the past 50 years, the Shishou reach in the middle Yangtze River underwent significant channel evolution owing to the implementation of an artificial cutoff, the construction of bank revetment works and the operation of the Three Gorges Project (TGP). Based on the measured hydrological data and topographic data, the processes of channel evolution in this reach were investigated mainly from the adjustments in planform and cross-sectional geometries. The variation in planform geometry obtained in this study indicates that (i) the artificial cutoff at Zhongzhouzi caused the river regime to adjust drastically, with the mean rate of thalweg migration at reach scale of 42.0 m/a over the period 1966-1975; (ii) then the effect of this artificial cutoff reduced gradually, with the mean migration rate decreasing to 40 m/a owing to the occurrence of high water levels in 1993-1998; and (iii) the average annual rate of thalweg migration decreased to 29.3 m/a because of the impacts of various bank protection engineering and the TGP operation during the period 2002-2015. However, remarkable thalweg migration processes still occurred in local regions after the TGP operation, which resulted in significant bankline migration in local reaches of Beimenkou, Shijiatai, and Tiaoxiankou. In addition, the adjustments of bankfull channel geometry were investigated at section and reach scales after the TGP operation. Calculated results show that lateral channel migration in this reach was restricted by various river regulation works and that channel evolution was mainly characterized by an increase in bankfull depth and cross-sectional area. Empirical relationships were developed between the reach-scale bankfull dimensions (depth and area), the bankfull widths at specified sections, and the previous 5-year average fluvial erosion intensity during flood seasons, with high correlation degrees between them being obtained.

  16. Interplay of dendritic avalanches and gradual flux penetration in superconducting MgB2 films

    International Nuclear Information System (INIS)

    Shantsev, D V; Goa, P E; Barkov, F L; Johansen, T H; Kang, W N; Lee, S I

    2003-01-01

    Magneto-optical imaging was used to study a zero-field-cooled MgB 2 film at 9.6 K where in a slowly increasing field the flux penetrates by an abrupt formation of large dendritic structures. Simultaneously, a gradual flux penetration takes place, eventually covering the dendrites, and a detailed analysis of this process is reported. We find an anomalously high gradient of the flux density across a dendrite branch, and a peak value that decreases as the applied field increases. This unexpected behaviour is reproduced by flux creep simulations based on the non-local field-current relation in the perpendicular geometry. The simulations also provide indirect evidence that flux dendrites are formed at an elevated local temperature, consistent with a thermo-magnetic mechanism of the instability

  17. Reaching ignition in the tokamak

    International Nuclear Information System (INIS)

    Furth, H.P.

    1985-06-01

    This review covers the following areas: (1) the physics of burning plasmas, (2) plasma physics requirements for reaching ignition, (3) design studies for ignition devices, and (4) prospects for an ignition project

  18. Variation of Temperature and Precipitation in Urban Agglomeration and Prevention Suggestion of Waterlogging in Middle and Lower Reaches of Yangtze River

    Science.gov (United States)

    Na, Liu; Youjie, Jin; Jiaqi, Dai

    2018-03-01

    The variation trend of temperature and precipitation during flood season in the middle and lower reaches of the Yangtze River basin in recent 50 years and change characteristics of rainfall in five typical flood prone cities are analysed. Aiming at waterlogging problems in the urban agglomeration of middle and lower reaches of the Yangtze River, the comprehensive prevention and control suggestions are put forward. The results showed that: the temperature trend in the basin decreased and then increased, and the precipitation showed a downward-rising-downward trend, no mutation occurred; The incidence of heavy rainfall events in the five typical cities with daily rainfall more than 50mm showed an upward trend, and increased significantly after 2002. The intensity of precipitation increased gradually. Climate change makes urban agglomeration waterlogging disasters become increasingly prominent in the middle and lower reaches of the Yangtze River.

  19. Assessing the economic feasibility of the gradual decarbonization of a large electric power system

    DEFF Research Database (Denmark)

    Santos-Alamillos, Francisco; Archer, Cristina; Noel, Lance Douglas

    2017-01-01

    The decarbonization of power systems is among the primary actions to fight air pollution and climate change. In this study, we evaluate the costs of a gradual transition towards a new power system in which the oldest coal plants are replaced with low-carbon power plants. We developed the Wind...... Energy Integration Cost Advisor Model (WEICAM) to analyze different strategies for this energy transition and determine the most cost-effective roadmap, with and without externalities. The test case is the PJM Interconnection, one of the power systems in the United States with the largest fraction...... decommissioned and an increase in the levelized cost of electricity from 49.1 to 53.6 $/MWh (without externalities). In addition, selecting the windiest sites – even far away from the PJM region – is cheaper than selecting local but less windy sites. When externalities due to human health and environmental...

  20. Gradual and Cumulative Improvements to the Classical Differential Evolution Scheme through Experiments

    Directory of Open Access Journals (Sweden)

    Anescu George

    2016-12-01

    Full Text Available The paper presents the experimental results of some tests conducted with the purpose to gradually and cumulatively improve the classical DE scheme in both efficiency and success rate. The modifications consisted in the randomization of the scaling factor (a simple jitter scheme, a more efficient Random Greedy Selection scheme, an adaptive scheme for the crossover probability and a resetting mechanism for the agents. After each modification step, experiments have been conducted on a set of 11 scalable, multimodal, continuous optimization functions in order to analyze the improvements and decide the new improvement direction. Finally, only the initial classical scheme and the constructed Fast Self-Adaptive DE (FSA-DE variant were compared with the purpose of testing their performance degradation with the increase of the search space dimension. The experimental results demonstrated the superiority of the proposed FSA-DE variant.

  1. Gradual pressure-induced change in the magnetic structure of the noncollinear antiferromagnet Mn3Ge

    Science.gov (United States)

    Sukhanov, A. S.; Singh, Sanjay; Caron, L.; Hansen, Th.; Hoser, A.; Kumar, V.; Borrmann, H.; Fitch, A.; Devi, P.; Manna, K.; Felser, C.; Inosov, D. S.

    2018-06-01

    By means of powder neutron diffraction we investigate changes in the magnetic structure of the coplanar noncollinear antiferromagnet Mn3Ge caused by an application of hydrostatic pressure up to 5 GPa. At ambient conditions the kagomé layers of Mn atoms in Mn3Ge order in a triangular 120∘ spin structure. Under high pressure the spins acquire a uniform out-of-plane canting, gradually transforming the magnetic texture to a noncoplanar configuration. With increasing pressure the canted structure fully transforms into the collinear ferromagnetic one. We observed that magnetic order is accompanied by a noticeable magnetoelastic effect, namely, spontaneous magnetostriction. The latter induces an in-plane magnetostrain of the hexagonal unit cell at ambient pressure and flips to an out-of-plane strain at high pressures in accordance with the change of the magnetic structure.

  2. Gradual unlocking of plate boundary controlled initiation of the 2014 Iquique earthquake.

    Science.gov (United States)

    Schurr, Bernd; Asch, Günter; Hainzl, Sebastian; Bedford, Jonathan; Hoechner, Andreas; Palo, Mauro; Wang, Rongjiang; Moreno, Marcos; Bartsch, Mitja; Zhang, Yong; Oncken, Onno; Tilmann, Frederik; Dahm, Torsten; Victor, Pia; Barrientos, Sergio; Vilotte, Jean-Pierre

    2014-08-21

    On 1 April 2014, Northern Chile was struck by a magnitude 8.1 earthquake following a protracted series of foreshocks. The Integrated Plate Boundary Observatory Chile monitored the entire sequence of events, providing unprecedented resolution of the build-up to the main event and its rupture evolution. Here we show that the Iquique earthquake broke a central fraction of the so-called northern Chile seismic gap, the last major segment of the South American plate boundary that had not ruptured in the past century. Since July 2013 three seismic clusters, each lasting a few weeks, hit this part of the plate boundary with earthquakes of increasing peak magnitudes. Starting with the second cluster, geodetic observations show surface displacements that can be associated with slip on the plate interface. These seismic clusters and their slip transients occupied a part of the plate interface that was transitional between a fully locked and a creeping portion. Leading up to this earthquake, the b value of the foreshocks gradually decreased during the years before the earthquake, reversing its trend a few days before the Iquique earthquake. The mainshock finally nucleated at the northern end of the foreshock area, which skirted a locked patch, and ruptured mainly downdip towards higher locking. Peak slip was attained immediately downdip of the foreshock region and at the margin of the locked patch. We conclude that gradual weakening of the central part of the seismic gap accentuated by the foreshock activity in a zone of intermediate seismic coupling was instrumental in causing final failure, distinguishing the Iquique earthquake from most great earthquakes. Finally, only one-third of the gap was broken and the remaining locked segments now pose a significant, increased seismic hazard with the potential to host an earthquake with a magnitude of >8.5.

  3. Photosynthetic performance of invasive Pinus ponderosa and Juniperus virginiana seedlings under gradual soil water depletion.

    Science.gov (United States)

    Bihmidine, S; Bryan, N M; Payne, K R; Parde, M R; Okalebo, J A; Cooperstein, S E; Awada, T

    2010-07-01

    Changes in climate, land management and fire regime have contributed to woody species expansion into grasslands and savannas worldwide. In the USA, Pinus ponderosa P.&C. Lawson and Juniperus virginiana L. are expanding into semiarid grasslands of Nebraska and other regions of the Great Plains. We examined P. ponderosa and J. virginiana seedling response to soil water content, one of the most important limiting factors in semiarid grasslands, to provide insight into their success in the region. Photosynthesis, stomatal conductance, maximum photochemical efficiency of PSII, maximum carboxylation velocity, maximum rate of electron transport, stomatal limitation to photosynthesis, water potential, root-to-shoot ratio, and needle nitrogen content were followed under gradual soil water depletion for 40 days. J. virginiana maintained lower L(s), higher A, g(s), and initial F(v)/F(m), and displayed a more gradual decline in V(cmax) and J(max) with increasing water deficit compared to P. ponderosa. J. virginiana also invested more in roots relative to shoots compared to P. ponderosa. F(v)/F(m) showed high PSII resistance to dehydration in both species. Photoinhibition was observed at approximately 30% of field capacity. Soil water content was a better predictor of A and g(s) than Psi, indicating that there are other growth factors controlling physiological processes under increased water stress. The two species followed different strategies to succeed in semiarid grasslands. P. ponderosa seedlings behaved like a drought-avoidant species with strong stomatal control, while J. virginiana was more of a drought-tolerant species, maintaining physiological activity at lower soil water content. Differences between the studied species and the ecological implications are discussed.

  4. The signature of undetected change: an exploratory electrotomographic investigation of gradual change blindness.

    Science.gov (United States)

    Kiat, John E; Dodd, Michael D; Belli, Robert F; Cheadle, Jacob E

    2018-05-01

    Neuroimaging-based investigations of change blindness, a phenomenon in which seemingly obvious changes in visual scenes fail to be detected, have significantly advanced our understanding of visual awareness. The vast majority of prior investigations, however, utilize paradigms involving visual disruptions (e.g., intervening blank screens, saccadic movements, "mudsplashes"), making it difficult to isolate neural responses toward visual changes cleanly. To address this issue in this present study, high-density EEG data (256 channel) were collected from 25 participants using a paradigm in which visual changes were progressively introduced into detailed real-world scenes without the use of visual disruption. Oscillatory activity associated with undetected changes was contrasted with activity linked to their absence using standardized low-resolution brain electromagnetic tomography (sLORETA). Although an insufficient number of detections were present to allow for analysis of actual change detection, increased beta-2 activity in the right inferior parietal lobule (rIPL), a region repeatedly associated with change blindness in disruption paradigms, followed by increased theta activity in the right superior temporal gyrus (rSTG) was noted in undetected visual change responses relative to the absence of change. We propose the rIPL beta-2 activity to be associated with orienting attention toward visual changes, with the subsequent rise in rSTG theta activity being potentially linked with updating preconscious perceptual memory representations. NEW & NOTEWORTHY This study represents the first neuroimaging-based investigation of gradual change blindness, a visual phenomenon that has significant potential to shed light on the processes underlying visual detection and conscious perception. The use of gradual change materials is reflective of real-world visual phenomena and allows for cleaner isolation of signals associated with the neural registration of change relative to the

  5. Quantile index for gradual and abrupt change detection from CFB boiler sensor data in online settings

    NARCIS (Netherlands)

    Maslov, A.; Pechenizkiy, M.; Kärkkäinen, T.; Tähtinen, M.

    2012-01-01

    In this paper we consider the problem of online detection of gradual and abrupt changes in sensor data having high levels of noise and outliers. We propose a simple heuristic method based on the Quantile Index (QI) and study how robust this method is for detecting both gradual and abrupt changes

  6. Gradual regeneration of mouse testicular stem cells after exposure to ionizing radiation

    International Nuclear Information System (INIS)

    Meistrich, M.L.; Hunter, N.R.; Suzuki, N.; Trostle, P.K.; Withers, H.R.

    1978-01-01

    The regeneration of mouse testicular stem cells during 60 weeks after exposure to 600 or 1200 rad of γ radiation was examined. Restoration of spermatogenesis depended on stem cell survival, regeneration, and differentiation. Several assays were employed to measure the number of stem cells and their ability to repopulate the seminiferous epithelium as follows. Assay 1: The percentage of repopulated tubular cross sections was determined histologically at various times after irradiation. Assay 2: Mice were irradiated and, after given time intervals to allow for regeneration of stem cell numbers, a second dose was given. The percentage of repopulated tubular cross sections was determined 5 weeks later. Assay 3: The ability of the stem cells to produce spermatocytes and spermatids was assayed by the levels of the germ cell specific isoenzyme, LDH-X. Assay 4: The ability of the stem cells to produce sperm was assayed by the number of sperm heads in the testes. In addition, the ability of the stem cells to produce functional spermatozoa was measured by the fertility of the animals. The results obtained were as follows. All assays demonstrated that gradual regeneration of stem cell number occurred simultaneously with repopulation of the seminiferous epithelium by differentiating cells derived from stem cells. The regeneration kinetics of stem cells followed an exponential increase approaching a dose-dependent plateau below the level prior to irradiation. The doubling time for stem cells during the exponential portion was about 2 weeks. The regeneration of stem cell number after depletion by irradiation was gradual and incomplete, and only partially restored spermatogenesis. Correlation of regeneration with fertility data demonstrated that fertility was reestablished when sperm production returned to about 15% of control levels

  7. RECORDS REACHING RECORDING DATA TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    G. W. L. Gresik

    2013-07-01

    Full Text Available The goal of RECORDS (Reaching Recording Data Technologies is the digital capturing of buildings and cultural heritage objects in hard-to-reach areas and the combination of data. It is achieved by using a modified crane from film industry, which is able to carry different measuring systems. The low-vibration measurement should be guaranteed by a gyroscopic controlled advice that has been , developed for the project. The data were achieved by using digital photography, UV-fluorescence photography, infrared reflectography, infrared thermography and shearography. Also a terrestrial 3D laser scanner and a light stripe topography scanner have been used The combination of the recorded data should ensure a complementary analysis of monuments and buildings.

  8. Records Reaching Recording Data Technologies

    Science.gov (United States)

    Gresik, G. W. L.; Siebe, S.; Drewello, R.

    2013-07-01

    The goal of RECORDS (Reaching Recording Data Technologies) is the digital capturing of buildings and cultural heritage objects in hard-to-reach areas and the combination of data. It is achieved by using a modified crane from film industry, which is able to carry different measuring systems. The low-vibration measurement should be guaranteed by a gyroscopic controlled advice that has been , developed for the project. The data were achieved by using digital photography, UV-fluorescence photography, infrared reflectography, infrared thermography and shearography. Also a terrestrial 3D laser scanner and a light stripe topography scanner have been used The combination of the recorded data should ensure a complementary analysis of monuments and buildings.

  9. Study of gradual conversion of Al to insulator by oxygen implantation

    International Nuclear Information System (INIS)

    Prabhawalker, P.D.; Raole, P.M.; Kothari, D.C.; Pawer, P.S.; Gogawale, S.V.

    1986-01-01

    30 keV O 2 + ions are implanted in aluminium foil, at various doses ranging from 5 x 10 16 to 5 x 10 17 atoms cm -2 . The sheet resistance was measured for unimplanted and implanted specimens. Up to the dose of 3 x 10 17 atoms cm -2 , the sheet resistance gradually increased. It formed a perfect insulating layer on the surface, above a dose of 3 x 10 17 atoms cm -2 . X-ray photo-electron spectroscopy measurements indicated the formation of an Al 2 O 3 layer with the absence of a signal due to unbonded aluminium for a dose of 5 x 10 17 atoms cm -2 . Whereas a specimen implanted at 5 x 10 16 atoms cm -2 shows the presence of pure aluminium. Micrographs of the specimen implanted at the higher dose displayed the microtopography characteristic of alumina. The results are in agreement with a recently published mechanism of Al 2 O 3 formation. The Al 2 O 3 precipitates increasing with dose and a layer of Al 2 O 3 being formed at the doses higher than that required to form the stoichiometric Al 2 O 3 . (author)

  10. Disassociation between primary motor cortical activity and movement kinematics during adaptation to reach perturbations.

    Science.gov (United States)

    Cai, X; Shimansky, Y P; Weber, D J; He, Jiping

    2004-01-01

    The relationship between movement kinematics and motor cortical activity was studied in monkeys performing a center-out reaching task during their adaptation to force perturbations applied to the wrist. The main feature of adaptive changes in movement kinematics was anticipatory deviation of hand paths in the direction opposite to that of the upcoming perturbation. We identified a group of neurons in the dorsal lateral portion of the primary motor cortex where a gradual buildup of spike activity immediately preceding the actual (in perturbation trials) or the "would-be" (in unperturbed/catch trials) perturbation onset was observed. These neurons were actively involved in the adaptation process, which was evident from the gradual increase in the amplitude of their movement-related modulation of spike activity from virtual zero and development of certain directional tuning pattern (DTP). However, the day-to-day dynamics of the kinematics adaptation was dramatically different from that of the neuronal activity. Hence, the adaptive modification of the motor cortical activity is more likely to reflect the development of the internal model of the perturbation dynamics, rather than motor instructions determining the adaptive behavior.

  11. REACH and nanomaterials: current status

    International Nuclear Information System (INIS)

    Alessandrelli, Maria; Di Prospero Fanghella, Paola; Polci, Maria Letizia; Castelli, Stefano; Pettirossi, Flavio

    2015-01-01

    New challenges for regulators are emerging about a specific assessment and appropriate management of the potential risks of nanomaterials. In the framework of European legislation on chemicals, Regulation (EC) No. 1907/2006 REACH aims to ensure the safety of human health and the environment through the collection of information on the physico-chemical characteristics of the substances and on their profile (eco) toxicological and the identification of appropriate risk management linked to 'exposure to these substances without impeding scientific progress and the competitiveness of industry. In order to cover the current shortage of information on the safety of nanomaterials and tackle the acknowledged legal vacuum, are being a rich activities, carried out both by regulators both by stake holders, and discussions on the proposals for adapting the European regulatory framework for chemicals . The European Commission is geared to strengthen the REACH Regulation by means of updates of its annexes. The importance of responding to the regulatory requirements has highlighted the need for cooperation between European organizations, scientists and industries to promote and ensure the safe use of nanomaterials. [it

  12. Technique for fabrication of gradual standards of radiographic image blachening density

    International Nuclear Information System (INIS)

    Borovin, I.V.; Kondina, M.A.

    1987-01-01

    The technique of fabrication of gradual standards of blackening density for industrial radiography by contact printing from a negative is described. The technique is designed for possibilities of industrial laboratoriesof radiation defectoscopy possessing no special-purpose sensitometric equipment

  13. Method for modeling the gradual physical degradation of a porous material

    Energy Technology Data Exchange (ETDEWEB)

    Flach, Greg [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-09-20

    Cementitious and other engineered porous materials encountered in waste disposals may degrade over time due to one or more mechanisms. Physical degradation may take the form of cracking (fracturing) and/or altered (e.g. increased) porosity, depending on the material and underlying degradation mechanism. In most cases, the hydraulic properties of degrading materials are expected to evolve due to physical changes occurring over roughly the pore to decimeter scale, which is conducive to calculating equivalent or effective material properties. The exact morphology of a degrading material in its end-state may or may not be known. In the latter case, the fully-degraded condition can be assumed to be similar to a more-permeable material in the surrounding environment, such as backfill soil. Then the fully-degraded waste form or barrier material is hydraulically neutral with respect to its surroundings, constituting neither a barrier to nor conduit for moisture flow and solute transport. Unless the degradation mechanism is abrupt, a gradual transition between the intact initial and fully-degraded final states is desired. Linear interpolation through time is one method for smoothly blending hydraulic properties between those of an intact matrix and those of a soil or other surrogate for the end-state.

  14. Reliability assessment of aging structures subjected to gradual and shock deteriorations

    International Nuclear Information System (INIS)

    Wang, Cao; Zhang, Hao; Li, Quanwang

    2017-01-01

    Civil structures and infrastructure facilities are susceptible to deterioration posed by the effects of natural hazards and aggressive environmental conditions. These factors may increase the risk of service interruption of infrastructures, and should be taken into account when assessing the structural reliability during an infrastructure's service life. Modeling the resistance deterioration process reasonably is the basis for structural reliability analysis. In this paper, a novel model is developed for describing the deterioration of aging structures. The deterioration is a combination of two stochastic processes: the gradual deterioration posed by environmental effects and the shock deterioration caused by severe load attacks. The dependency of the deterioration magnitude on the load intensity is considered. The Gaussian copula function is employed to help construct the joint distribution of correlated random variables. Semi-analytical methods are developed to assess the structural failure time and the number of significant load events (shocks) to failure. Illustrative examples are presented to demonstrate the applicability of the proposed model in structural reliability analysis. Parametric studies are performed to investigate the role of deterioration-load correlation in structural reliability. - Highlights: • A new resistance deterioration model for aging structures is proposed. • Time-dependent reliability analysis methods incorporating the proposed deterioration model are developed. • Parametric studies are performed to investigate the role of deterioration-load correlation in structural reliability.

  15. Method for modeling the gradual physical degradation of a porous material

    International Nuclear Information System (INIS)

    Flach, Greg

    2017-01-01

    Cementitious and other engineered porous materials encountered in waste disposals may degrade over time due to one or more mechanisms. Physical degradation may take the form of cracking (fracturing) and/or altered (e.g. increased) porosity, depending on the material and underlying degradation mechanism. In most cases, the hydraulic properties of degrading materials are expected to evolve due to physical changes occurring over roughly the pore to decimeter scale, which is conducive to calculating equivalent or effective material properties. The exact morphology of a degrading material in its end-state may or may not be known. In the latter case, the fully-degraded condition can be assumed to be similar to a more-permeable material in the surrounding environment, such as backfill soil. Then the fully-degraded waste form or barrier material is hydraulically neutral with respect to its surroundings, constituting neither a barrier to nor conduit for moisture flow and solute transport. Unless the degradation mechanism is abrupt, a gradual transition between the intact initial and fully-degraded final states is desired. Linear interpolation through time is one method for smoothly blending hydraulic properties between those of an intact matrix and those of a soil or other surrogate for the end-state.

  16. Improving exposure scenario definitions within REACH

    DEFF Research Database (Denmark)

    Lee, Jihyun; Pizzol, Massimo; Thomsen, Marianne

    In recent years, the paradigm of chemical management system has changed from being toxicity oriented and media based to being risk oriented and receptor based. This trend is evident not only regarding environmental quality standards, but also for industrial chemical regulations. Political...... instruments to support a precautionary chemicals management system and to protect receptor’s health have also been increasing. Since 2007, the European Union adopted REACH (the Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals): REACH makes industry responsible for assessing...... and managing the risks posed by industrial chemicals and providing appropriate safety information to their users (EC, 2007). However, to ensure a high level of protection of human health and the environment, there is a need to consider ‘aggregate exposure’ including background exposures from environment which...

  17. Dry Bean Morpho-Physiological Responses to Gradual Weed Biomass Accumulation

    Directory of Open Access Journals (Sweden)

    Hossein GHAMARI

    2013-02-01

    Full Text Available Field study was carried out in 2011 in west of Iran to assess responses of dry bean (Phaseolus vulgaris L. morpho-physiological traits to gradual weed biomass accumulation. The treatments consisted of two different periods of weed interference, which weeds either infested the plots or removed for an increasing duration of time (0, 10, 20, 30, 40, 50 days after crop emergence. Relative dominance and relative importance of weed species fluctuated over the crop cycle. As the duration of weed interference was increased, a declining trend of crop growth rate (CGR was observed. When weeds were allowed to compete with crop throughout the crop cycle, maximum value of CGR was decreased from 25.57 g m-2 days in full season weed free treatment to 16.78 g m-2 days in full season weed infested treatment. Effect of treatments on leaf area index (LAI was significant. Weed removal increased LAI but it could not significantly affect this trait, at the early of growing season. Weed interference caused a significant reduction on number of branches. The minimum number of branches was registered in full season weed infested treatment (2.58 branches per plant, while the maximum one was observed in the full season weed free treatment (4.25 branches per plant. Weed competition severely reduced crop yield. At 10 and 20 days after crop emergence, weed infestation could not significantly affect the yield. A negative relationship between weeds’ dry matter accumulation and LAI as well as number of branches was observed which signify the vulnerability of these morpho-physiological traits to weed competition.

  18. Reaching for the red planet

    Science.gov (United States)

    David, L

    1996-05-01

    The distant shores of Mars were reached by numerous U.S. and Russian spacecraft throughout the 1960s to mid 1970s. Nearly 20 years have passed since those successful missions which orbited and landed on the Martian surface. Two Soviet probes headed for the planet in July, 1988, but later failed. In August 1993, the U.S. Mars Observer suddenly went silent just three days before it was to enter orbit around the planet and was never heard from again. In late 1996, there will be renewed activity on the launch pads with three probes departing for the red planet: 1) The U.S. Mars Global Surveyor will be launched in November on a Delta II rocket and will orbit the planet for global mapping purposes; 2) Russia's Mars '96 mission, scheduled to fly in November on a Proton launcher, consists of an orbiter, two small stations which will land on the Martian surface, and two penetrators that will plow into the terrain; and finally, 3) a U.S. Discovery-class spacecraft, the Mars Pathfinder, has a December launch date atop a Delta II booster. The mission features a lander and a microrover that will travel short distances over Martian territory. These missions usher in a new phase of Mars exploration, setting the stage for an unprecedented volley of spacecraft that will orbit around, land on, drive across, and perhaps fly at low altitudes over the planet.

  19. Metasurface holograms reaching 80% efficiency.

    Science.gov (United States)

    Zheng, Guoxing; Mühlenbernd, Holger; Kenney, Mitchell; Li, Guixin; Zentgraf, Thomas; Zhang, Shuang

    2015-04-01

    Surfaces covered by ultrathin plasmonic structures--so-called metasurfaces--have recently been shown to be capable of completely controlling the phase of light, representing a new paradigm for the design of innovative optical elements such as ultrathin flat lenses, directional couplers for surface plasmon polaritons and wave plate vortex beam generation. Among the various types of metasurfaces, geometric metasurfaces, which consist of an array of plasmonic nanorods with spatially varying orientations, have shown superior phase control due to the geometric nature of their phase profile. Metasurfaces have recently been used to make computer-generated holograms, but the hologram efficiency remained too low at visible wavelengths for practical purposes. Here, we report the design and realization of a geometric metasurface hologram reaching diffraction efficiencies of 80% at 825 nm and a broad bandwidth between 630 nm and 1,050 nm. The 16-level-phase computer-generated hologram demonstrated here combines the advantages of a geometric metasurface for the superior control of the phase profile and of reflectarrays for achieving high polarization conversion efficiency. Specifically, the design of the hologram integrates a ground metal plane with a geometric metasurface that enhances the conversion efficiency between the two circular polarization states, leading to high diffraction efficiency without complicating the fabrication process. Because of these advantages, our strategy could be viable for various practical holographic applications.

  20. ["Tied down"--the process of becoming bedridden through gradual local confinement].

    Science.gov (United States)

    Zegelin, Angelika

    2005-10-01

    To be bedridden is a common phenomenon in nursing. However, there is no solid base of knowledge on reasons, types, development of and coping with this situation. The concept of being bedridden is applied in an arbitrary manner and the state of being bedridden is far from being clearly defined. A literature review revealed that only pathophysiological effects of this state are sufficiently explained. The aim of this study was to gain knowledge of the development of being confined to bed. Thirty-two interviews with elderly, bedridden people (nineteen women, thirteen men) were conducted. They were asked about their perspective on and their experience of the development of being confined to bed. Half of the interviewees lived in a nursing home, the others were cared for at home. Data collection and analysis were performed by using a Grounded Theory approach as developed by Strauss and Corbin. "Gradual local fixation" was identified as the core category. Becoming bedridden is a slow process by which the person is increasingly confined to one location. This development is related to an increasing need for support and to negative consequences such as a pathology of immobility, narrowing of interests, and loss of time. These consequences again are responsible for a downward spiral development. This study reveals phases of development and a range of factors influencing them. Many of these factors arise from the person and his/her interactional behaviour in the circumstances, other influences are structural factors such as external pressure caused by time constraints of professional nursing services or unfavourable arrangements of furniture. A lot of factors of being confined to bed are changeable. Long periods of being bedridden can be prevented in many cases, if early warning signs are being recognized and preventive measures are taken in time.

  1. Has Silicon Reached It's Limit?

    Directory of Open Access Journals (Sweden)

    Alan John Charles Davidson

    2014-01-01

    Full Text Available In light of the rapidly increasing demand for ultra-high speed data transmission, data centres are under pressure to provide ever increasing data transmission through their networks and at the same time improve the quality of data handling in terms of reduced latency, increased scalability and improved channel speed for users. However as data rates increase, present electronic switching technology using current data centre architecture is becoming increasingly difficult to scale despite improvements in data management. In this paper the tremendous bandwidth potential of optical fibre based networks will be explored alongside the issues of electronic scalability and switching speed. A resulting need for alternative optical solutions for all-optical signal processing systems will be discussed. With this in mind, progress in the form of a novel and highly scalable optical interconnect will be reviewed.

  2. Tissue specific responses alter the biomass accumulation in wheat under gradual and sudden salt stress

    Directory of Open Access Journals (Sweden)

    Yumurtaci A.

    2012-11-01

    Full Text Available Salinity is one the major limiting environmental factors which has negative side effects on crop production. The purpose of this study was to investigate the differences between the gradual and sudden salt stress effects on biomass accumulation associated with whole plant development in three different tissues of two wheat species ( Triticum aestivum and Triticum durum under hydroponic conditions in the long term. Considering the effects of sudden and gradual stress for biomass accumulation, while importance of salinity x genotype interaction for fresh weights was 5%, association for salinity x tissue type was found as 1% important. Interestingly, root branching and development of lateral roots were much more negatively affected by gradual stress rather than sudden salt application. Our results demonstrated that root and leaf were both critical tissues to test the salt tolerance by physiologically but sheath tissue might be used as an alternative source of variation for solving the interactions between root and leaves in wheat.

  3. Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia.

    Science.gov (United States)

    Comelon, M; Raeder, J; Stubhaug, A; Nielsen, C S; Draegni, T; Lenz, H

    2016-04-01

    The aim of this study was to examine if gradual withdrawal of remifentanil infusion prevented opioid-induced hyperalgesia (OIH) as opposed to abrupt withdrawal. OIH duration was also evaluated. Nineteen volunteers were enrolled in this randomized, double-blinded, placebo-controlled, crossover study. All went through three sessions: abrupt or gradual withdrawal of remifentanil infusion and placebo. Remifentanil was administered at 2.5 ng ml(-1) for 30 min before abrupt withdrawal or gradual withdrawal by 0.6 ng ml(-1) every five min. Pain was assessed at baseline, during infusion, 45-50 min and 105-110 min after end of infusions using the heat pain test (HPT) and the cold pressor test (CPT). The HPT 45 min after infusion indicated OIH development in the abrupt withdrawal session with higher pain scores compared with the gradual withdrawal and placebo sessions (both Pwithdrawal compared with placebo (P=0.93). In the CPT 50 min after end of infusion there was OIH in both remifentanil sessions compared with placebo (gradual P=0.01, abrupt Pwithdrawal of remifentanil infusion in the HPT. After abrupt withdrawal OIH was present in the HPT. In the CPT there was OIH after both gradual and abrupt withdrawal of infusion. The duration of OIH was less than 105 min for both pain modalities. NCT 01702389. EudraCT number 2011-002734-39. © The Author 2016. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. A farm-level analysis of economic and agronomic impacts of gradual climate warming

    International Nuclear Information System (INIS)

    Kaiser, H.M.; Sampath, R.; Riha, S.J.; Wilks, D.S.; Rossiter, D.G.

    1993-01-01

    The potential economic and agronomic impacts of gradual climate warming are examined at the farm level. Three models of the relevant climatic, agronomic, and economic processes are developed and linked to address climate change impacts and agricultural adaptability. Several climate warming severity. The results indicate that grain farmers in southern Minnesota can effectively adapt to a gradually changing climate (warmer and either wetter or drier) by adopting later maturing cultivars, changing crop mix, and altering the timing of field operations to take advantage of a longer growing season resulting from climate warming

  5. Testing gradual and speciational models of evolution in extant taxa: the example of ratites

    NARCIS (Netherlands)

    Laurin, M.; Gussekloo, S.W.S.; Marjanovic, D.; Legendre, L.; Cubo, J.

    2012-01-01

    Ever since Eldredge and Gould proposed their model of punctuated equilibria, evolutionary biologists have debated how often this model is the best description of nature and how important it is compared to the more gradual models of evolution expected from natural selection and the neo-Darwinian

  6. Locating spare part warehouses using the concept of gradual coverage - A case study

    DEFF Research Database (Denmark)

    Hansen, Klaus Reinholdt Nyhuus; Grunow, Martin

    2009-01-01

    for MAN Diesel SE is presented, where gradual coverage has been used for locating warehouses for spare parts. In particular it is described, how coverage decay functions are found, which identifies customers’ reaction to the offered ’speed of delivery’ and ’total order cost’. With these functions, demand...

  7. Evaluation of gradual occlusion of the caudal vena cava in clinically normal dogs.

    Science.gov (United States)

    Peacock, John T; Fossum, Theresa W; Bahr, Anne M; Miller, Matthew W; Edwards, John F

    2003-11-01

    To devise a technique for gradual occlusion of the caudal vena cava in dogs and determine effects of complete occlusion of the caudal vena cava. 8 mixed-breed hounds that weighed between 25 and 30 kg. Baseline evaluation of dogs included serum biochemical analyses and determination of glomerular filtration rate (GFR) with dynamic renal scintigraphy and plasma clearance analysis. An occluder was placed around the vena cava in the region cranial to the renal veins. The occluder was attached to a vascular access port. The vena cava was gradually occluded over 2 weeks. The GFR was measured every 2 weeks after surgery, and venograms were performed every 3 weeks after surgery. Blood samples were collected every 48 hours for the first week and then weekly thereafter to measure BUN and creatinine concentrations and activities of alanine transaminase, alkaline phosphatase, and creatinine kinase. Dogs were euthanatized 6 weeks after surgery, and tissues were submitted for histologic examination. The GFR and biochemical data were compared with baseline values. Gradual occlusion of the caudal vena cava was easily and consistently performed with this method, and adverse clinical signs were not detected. Formation of collateral vessels allowed overall GFR to remain constant despite a decrease in function of the left kidney. Measured biochemical values did not deviate from reference ranges. Gradual occlusion of the caudal vena cava may allow removal of adrenal gland tumors with vascular invasion that would otherwise be difficult or impossible to resect.

  8. Reflecting on Talk: A Mentor Teacher's Gradual Release in Co-Planning

    Science.gov (United States)

    Pylman, Stacey

    2016-01-01

    The goal of this case study was to explore how a mentor teacher used video-recorded co-planning sessions to reflect on and improve one's mentoring practice. Findings reveal ways in which the mentor used talk in co-planning sessions to model one's thinking process and to gradually release planning responsibility to engage the intern in learning to…

  9. Abrupt rather than gradual hormonal changes induce postpartum blues-like behavior in rats

    NARCIS (Netherlands)

    Doornbos, Bennard; Fokkema, Dirk S.; Molhoek, Margo; Tanke, Marit A. C.; Postema, Folkert; Korf, Jakob

    2009-01-01

    Aims: Postpartum blues is thought to be related to hormonal events accompanying delivery. We investigated whether blues-like symptoms depend on the rate of the decline of hormones, by comparing the behavioral consequences of an abrupt versus a gradual decline of gonadal hormones in an animal model.

  10. Quantifying short run cost-effectiveness during a gradual implementation process

    NARCIS (Netherlands)

    Wetering, G. van de; Woertman, W.H.; Verbeek, A.L.M.; Broeders, M.J.M.; Adang, E.M.M.

    2013-01-01

    This paper examines the short run inefficiencies that arise during gradual implementation of a new cost-effective technology in healthcare. These inefficiencies arise when health gains associated with the new technology cannot be obtained immediately because the new technology does not yet supply

  11. Should these potential CMR substances have been registered under REACH?

    DEFF Research Database (Denmark)

    Wedebye, Eva Bay; Nikolov, Nikolai Georgiev; Dybdahl, Marianne

    2013-01-01

    (Q)SAR models were applied to screen around 68,000 REACH pre-registered substances for CMR properties (carcinogenic, mutagenic or toxic to reproduction). Predictions from 14 relevant models were combined to reach overall calls for C, M and R. Combining predictions may reduce “noise” and increase...

  12. ALMA Telescope Reaches New Heights

    Science.gov (United States)

    2009-09-01

    ball at a distance of nine miles, and to keep their smooth reflecting surfaces accurate to less than the thickness of a human hair. Once the transporter reached the high plateau it carried the antenna to a concrete pad -- a docking station with connections for power and fiber optics -- and positioned it with an accuracy of a small fraction of an inch. The transporter is guided by a laser steering system and, just like some cars, also has ultrasonic collision detectors. These sensors ensure the safety of the state-of-the-art antennas as the transporter drives them across what will soon be a rather crowded plateau. Ultimately, ALMA will have at least 66 antennas distributed over about 200 pads, spread over distances of up to 11.5 miles and operating as a single, giant telescope. Even when ALMA is fully operational, the transporters will be used to move the antennas between pads to reconfigure the telescope for different kinds of observations. This first ALMA antenna at the high site will soon be joined by others, and the ALMA team looks forward to making their first observations from the Chajnantor plateau. They plan to link three antennas by early 2010, and to make the first scientific observations with ALMA in the second half of 2011. ALMA will help astronomers answer important questions about our cosmic origins. The telescope will observe the Universe using light with millimeter and submillimeter wavelengths, between infrared light and radio waves in the electromagnetic spectrum. Light at these wavelengths comes from some of the coldest, and from some of the most distant objects in the cosmos. These include cold clouds of gas and dust where new stars are being born, or remote galaxies towards the edge of the observable universe. The Universe is relatively unexplored at submillimeter wavelengths, as the telescopes need extremely dry atmospheric conditions, such as those at Chajnantor, and advanced detector technology. The Atacama Large Millimeter/submillimeter Array

  13. Can gradual dose titration of ketamine for management of neuropathic pain prevent psychotomimetic effects in patients with advanced cancer?

    Science.gov (United States)

    Okamoto, Yoshiaki; Tsuneto, Satoru; Tanimukai, Hitoshi; Matsuda, Yoichi; Ohno, Yumiko; Tsugane, Mamiko; Uejima, Etsuko

    2013-08-01

    Ketamine is often used to manage neuropathic pain in patients with cancer. However, it occasionally causes psychotomimetic effects such as vivid dreams, nightmares, illusions, hallucinations, and altered body image. To examine whether gradual dose titration of ketamine for management of neuropathic pain prevents psychotomimetic effects in patients with advanced cancer. This was a retrospective chart review. We administered ketamine when neuropathic pain in patients with advanced cancer became refractory to opioids and oral adjuvant analgesics. The starting dose of ketamine was 10 mg/d by continuous intravenous infusion. The dose was gradually increased by 10 mg/d every 4 to 6 hours to 50 mg/d or until the pain was relieved. It was subsequently increased by 25 mg/d every 12 to 24 hours until the pain was relieved. For this study, we enrolled 46 patients with advanced cancer. The mean age was 52.2 ± 16.9 years. The mean dose at onset of action and maximum dose of ketamine were 56 ± 58 and 272 ± 214 mg/d, respectively. The mean pain intensity (numerical rating scale) decreased significantly from 7.3 ± 2.0 to 3.5 ± 2.2 after the administration of ketamine (P ketamine for management of neuropathic pain can prevent psychotomimetic effects in patients with advanced cancer.

  14. 'Tied down'- the process of becoming bedridden through gradual local confinement.

    Science.gov (United States)

    Zegelin, Angelika

    2008-09-01

    To raise awareness of the process of being bedridden, to create knowledge about the different causes and types of being bedridden, to highlight what exactly constitutes being bedridden, to describe which factors influence being bedridden. Being bedridden is a common phenomenon in nursing. However, there is no solid base of knowledge on reasons, types, development of and coping with this situation. The concept of being bedridden is applied in an arbitrary manner and the state of being bedridden is far from being clearly defined. A literature review revealed that only pathophysiological effects of this state are sufficiently explained. The aim of this study was to gain knowledge of the development of being confined to bed. Data collection and analysis were performed by using a Grounded Theory approach as developed by Strauss and Corbin. Thirty-two interviews with older, bedridden people were conducted. They were asked about their perspective on and their experience of the development of being confined to bed. Half of the interviewees lived in a nursing home, the others were cared for at home. 'Gradual local confinement' was identified as the core category. Becoming bedridden is a slow process by which the person is increasingly confined to one location. This development is related to an increasing need for support and to negative consequences, such as a pathology of immobility, narrowing of interests and loss of time. These consequences again are responsible for a downward spiral development. The study is the first research on the topic of being bedridden; no research in this field had been done before. There are some research results on bedrest, based on a purely medical perspective. The problem of being bedridden from the perspective of nursing is totally different. This study reveals phases of development and a range of factors influencing the problem of becoming bedridden. Many of these factors arise from the person and his/her interactional behaviour in the

  15. Volcanic gas composition changes during the gradual decrease of the gigantic degassing activity of Miyakejima volcano, Japan, 2000-2015

    Science.gov (United States)

    Shinohara, Hiroshi; Geshi, Nobuo; Matsushima, Nobuo; Saito, Genji; Kazahaya, Ryunosuke

    2017-02-01

    The composition of volcanic gases discharged from Miyakejima volcano has been monitored during the intensive degassing activity that began after the eruption in 2000. During the 15 years from 2000 to 2015, Miyakejima volcano discharged 25.5 Mt of SO2, which required degassing of 3 km3 of basaltic magma. The SO2 emission rate peaked at 50 kt/day at the end of 2000 and quickly decreased to 5 kt/day by 2003. During the early degassing period, the volcanic gas composition was constant with the CO2/SO2 = 0.8 (mol ratio), H2O/SO2 = 35, HCl/SO2 = 0.08, and SO2/H2S = 15. The SO2 emission rate decreased gradually to 0.5 kt/day by 2012, and the gas composition also changed gradually to CO2/SO2 = 1.5, H2O/SO2 = 150, HCl/SO2 = 0.15, and SO2/H2S = 6. The compositional changes are not likely caused by changes in degassing pressure or volatile heterogeneity of a magma chamber but are likely attributed to an increase of hydrothermal scrubbing caused by large decrease of the volcanic gas emission rate, suggesting a supply of gases with constant composition during the 15 years. The intensive degassing was modeled based on degassing of a convecting magma conduit. The gradual SO2 emission rate that decrease without changes in volcanic gas composition is attributed to a reduction of diameter of the convecting magma conduit.

  16. Adaptive mixed reality rehabilitation improves quality of reaching movements more than traditional reaching therapy following stroke.

    Science.gov (United States)

    Duff, Margaret; Chen, Yinpeng; Cheng, Long; Liu, Sheng-Min; Blake, Paul; Wolf, Steven L; Rikakis, Thanassis

    2013-05-01

    Adaptive mixed reality rehabilitation (AMRR) is a novel integration of motion capture technology and high-level media computing that provides precise kinematic measurements and engaging multimodal feedback for self-assessment during a therapeutic task. We describe the first proof-of-concept study to compare outcomes of AMRR and traditional upper-extremity physical therapy. Two groups of participants with chronic stroke received either a month of AMRR therapy (n = 11) or matched dosing of traditional repetitive task therapy (n = 10). Participants were right handed, between 35 and 85 years old, and could independently reach to and at least partially grasp an object in front of them. Upper-extremity clinical scale scores and kinematic performances were measured before and after treatment. Both groups showed increased function after therapy, demonstrated by statistically significant improvements in Wolf Motor Function Test and upper-extremity Fugl-Meyer Assessment (FMA) scores, with the traditional therapy group improving significantly more on the FMA. However, only participants who received AMRR therapy showed a consistent improvement in kinematic measurements, both for the trained task of reaching to grasp a cone and the untrained task of reaching to push a lighted button. AMRR may be useful in improving both functionality and the kinematics of reaching. Further study is needed to determine if AMRR therapy induces long-term changes in movement quality that foster better functional recovery.

  17. Lucky to reach the top?

    DEFF Research Database (Denmark)

    Ottsen, Christina L.

    Purpose: As organizations become increasingly gender- and culturally diverse, it is important to understand how perspectives on work-related issues vary across gender, as well as how gender differences vary across cultures. In this respect, the perspective of future leaders is of particular impor...... future leaders. Changing the gender different perspective on luck likely balances the number of applicants for leadership positions across gender. Furthermore, awareness of different cultural perspectives facilitates cross-cultural collaboration....... importance. The current study examines university students’ perceptions of what it takes to be appointed to a leadership position. Methodology: Samples from Qatar and Denmark present a unique opportunity to investigate potential effects of gender because of different norms for men and women. A total of 124...... that women across cultures assessed that luck had less to do with getting appointed to a leadership position than men. Middle Eastern women perceived networking with individuals in powerful positions to be less related to leadership appointment compared to the rest of the participants. Cross...

  18. Operational Reach: Is Current Army Doctrine Adequate?

    National Research Council Canada - National Science Library

    Heintzelman, Scott

    2003-01-01

    The term operational reach, an element of operational design, is new to U.S. Army doctrine. Operational reach is not found in the previous edition of the Army's basic operational doctrine, Field Manual...

  19. Stream Habitat Reach Summary - NCWAP [ds158

    Data.gov (United States)

    California Natural Resource Agency — The Stream Habitat - NCWAP - Reach Summary [ds158] shapefile contains in-stream habitat survey data summarized to the stream reach level. It is a derivative of the...

  20. Driving gradual endogenous c-myc overexpression by flow-sorting: intracellular signaling and tumor cell phenotype correlate with oncogene expression

    DEFF Research Database (Denmark)

    Knudsen, Kasper Jermiin; Holm, G.M.N.; Krabbe, J.S.

    2009-01-01

    Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overex...

  1. Perspectives on monitoring gradual change across the continuity of Landsat sensors using time-series data

    Science.gov (United States)

    Vogelmann, James; Gallant, Alisa L.; Shi, Hua; Zhu, Zhe

    2016-01-01

    There are many types of changes occurring over the Earth's landscapes that can be detected and monitored using Landsat data. Here we focus on monitoring “within-state,” gradual changes in vegetation in contrast with traditional monitoring of “abrupt” land-cover conversions. Gradual changes result from a variety of processes, such as vegetation growth and succession, damage from insects and disease, responses to shifts in climate, and other factors. Despite the prevalence of gradual changes across the landscape, they are largely ignored by the remote sensing community. Gradual changes are best characterized and monitored using time-series analysis, and with the successful launch of Landsat 8 we now have appreciable data continuity that extends the Landsat legacy across the previous 43 years. In this study, we conducted three related analyses: (1) comparison of spectral values acquired by Landsats 7 and 8, separated by eight days, to ensure compatibility for time-series evaluation; (2) tracking of multitemporal signatures for different change processes across Landsat 5, 7, and 8 sensors using anniversary-date imagery; and (3) tracking the same type of processes using all available acquisitions. In this investigation, we found that data representing natural vegetation from Landsats 5, 7, and 8 were comparable and did not indicate a need for major modification prior to use for long-term monitoring. Analyses using anniversary-date imagery can be very effective for assessing long term patterns and trends occurring across the landscape, and are especially good for providing insights regarding trends related to long-term and continuous trends of growth or decline. We found that use of all available data provided a much more comprehensive level of understanding of the trends occurring, providing information about rate, duration, and intra- and inter-annual variability that could not be readily gleaned from the anniversary date analyses. We observed that using all

  2. Rapid Automatic Motor Encoding of Competing Reach Options

    Directory of Open Access Journals (Sweden)

    Jason P. Gallivan

    2017-02-01

    Full Text Available Mounting neural evidence suggests that, in situations in which there are multiple potential targets for action, the brain prepares, in parallel, competing movements associated with these targets, prior to implementing one of them. Central to this interpretation is the idea that competing viewed targets, prior to selection, are rapidly and automatically transformed into corresponding motor representations. Here, by applying target-specific, gradual visuomotor rotations and dissociating, unbeknownst to participants, the visual direction of potential targets from the direction of the movements required to reach the same targets, we provide direct evidence for this provocative idea. Our results offer strong empirical support for theories suggesting that competing action options are automatically represented in terms of the movements required to attain them. The rapid motor encoding of potential targets may support the fast optimization of motor costs under conditions of target uncertainty and allow the motor system to inform decisions about target selection.

  3. Estudio transcultural con la prueba de Bender: Sistema de puntuación gradual (Cross-Cultural Study with Bender Test- Gradual Scoring System

    Directory of Open Access Journals (Sweden)

    Fabián Javier Marín Rueda

    2013-12-01

    Full Text Available RESUMEN: El objetivo del presente estudio es comparar el desempeño en la Prueba Gestáltica Visomotriz de Bender - Sistema de Puntuación Gradual (B-SPG en un grupo de niños peruanos en función a los datos ofrecidos por el manual brasilero de la prueba. Participaron 82 niños, de ambos sexos, con edades entre los 8 y 10 años (M = 9.21, DT = 0.83. Los niños provenían de los distritos de Pueblo Libre (43.9% y Rímac (51.2%, de la provincia de Lima, así como también de Lima Metropolitana (4.9%. El B-SPG fue aplicado de forma colectiva. Los promedios de puntos obtenidos por los niños peruanos en el B-SPG fueron significativamente superiores a los obtenidos por los niños brasileros en cada una de las edades estudiadas. Se destaca la importancia de investigar evidencias de validez y de confiabilidad para que la prueba pueda ser usada de forma adecuada en el Perú, considerando las particularidades de desarrollo de los niños del país. ABSTRACT: The objective of the study is to compare performance on the Bender Visual Motor Gestalt test - system of Gradual punctuation (B-SPG in a group of Peruvian children in connection with the data provided by the Brazilian manual of the test. In this research 82 Peruvian children were involved, both sexes, with ages between 8 and 10 years (M = 9.21, DT = 0.83. The hildren came from the districts of Pueblo Libre (43.9% and Rimac (51.2% in the province of Lima, as well as from metropolitan Lima (4.9%. The B-SPG was collectively applied in the children’s schools. The average points earned by the Peruvian children in the B-SPG were significantly higher than those obtained by Brazilian children in each one of the ages studied. It emphasizes the importance of investigating evidence of validity and reliability, so that, the test can be used appropriately in Peru, considering the peculiarities of the development of children in the country.

  4. Floral pathway integrator gene expression mediates gradual transmission of environmental and endogenous cues to flowering time.

    Science.gov (United States)

    van Dijk, Aalt D J; Molenaar, Jaap

    2017-01-01

    The appropriate timing of flowering is crucial for the reproductive success of plants. Hence, intricate genetic networks integrate various environmental and endogenous cues such as temperature or hormonal statues. These signals integrate into a network of floral pathway integrator genes. At a quantitative level, it is currently unclear how the impact of genetic variation in signaling pathways on flowering time is mediated by floral pathway integrator genes. Here, using datasets available from literature, we connect Arabidopsis thaliana flowering time in genetic backgrounds varying in upstream signalling components with the expression levels of floral pathway integrator genes in these genetic backgrounds. Our modelling results indicate that flowering time depends in a quite linear way on expression levels of floral pathway integrator genes. This gradual, proportional response of flowering time to upstream changes enables a gradual adaptation to changing environmental factors such as temperature and light.

  5. Floral pathway integrator gene expression mediates gradual transmission of environmental and endogenous cues to flowering time

    Directory of Open Access Journals (Sweden)

    Aalt D.J. van Dijk

    2017-04-01

    Full Text Available The appropriate timing of flowering is crucial for the reproductive success of plants. Hence, intricate genetic networks integrate various environmental and endogenous cues such as temperature or hormonal statues. These signals integrate into a network of floral pathway integrator genes. At a quantitative level, it is currently unclear how the impact of genetic variation in signaling pathways on flowering time is mediated by floral pathway integrator genes. Here, using datasets available from literature, we connect Arabidopsis thaliana flowering time in genetic backgrounds varying in upstream signalling components with the expression levels of floral pathway integrator genes in these genetic backgrounds. Our modelling results indicate that flowering time depends in a quite linear way on expression levels of floral pathway integrator genes. This gradual, proportional response of flowering time to upstream changes enables a gradual adaptation to changing environmental factors such as temperature and light.

  6. Detecting gradual visual changes in colour and brightness agnosia: a double dissociation.

    Science.gov (United States)

    Nijboer, Tanja C W; te Pas, Susan F; van der Smagt, Maarten J

    2011-03-09

    Two patients, one with colour agnosia and one with brightness agnosia, performed a task that required the detection of gradual temporal changes in colour and brightness. The results for these patients, who showed anaverage or an above-average performance on several tasks designed to test low-level colour and luminance (contrast) perception in the spatial domain, yielded a double dissociation; the brightness agnosic patient was within the normal range for the coloured stimuli, but much slower to detect brightness differences, whereas the colour agnosic patient was within the normal range for the achromatic stimuli, but much slower for the coloured stimuli. These results suggest that a modality-specific impairment in the detection of gradual temporal changes might be related to, if not underlie, the phenomenon of visual agnosia.

  7. Computational issues of solving the 1D steady gradually varied flow equation

    Directory of Open Access Journals (Sweden)

    Artichowicz Wojciech

    2014-09-01

    Full Text Available In this paper a problem of multiple solutions of steady gradually varied flow equation in the form of the ordinary differential energy equation is discussed from the viewpoint of its numerical solution. Using the Lipschitz theorem dealing with the uniqueness of solution of an initial value problem for the ordinary differential equation it was shown that the steady gradually varied flow equation can have more than one solution. This fact implies that the nonlinear algebraic equation approximating the ordinary differential energy equation, which additionally coincides with the wellknown standard step method usually applied for computing of the flow profile, can have variable number of roots. Consequently, more than one alternative solution corresponding to the same initial condition can be provided. Using this property it is possible to compute the water flow profile passing through the critical stage.

  8. Proximal and distal adjustments of reaching behavior in preterm infants.

    Science.gov (United States)

    de Toledo, Aline Martins; Soares, Daniele de Almeida; Tudella, Eloisa

    2011-01-01

    The authors aimed to investigate proximal and distal adjustments of reaching behavior and grasping in 5-, 6-, and 7-month-old preterm infants. Nine low-risk preterm and 10 full-term infants participated. Both groups showed the predominance of unimanual reaching, an age-related increase in the frequency of vertical-oriented and open hand movement, and also an increase in successful grasping from 6 to 7 months. The frequency of open hand was higher in the preterm group at 6 months. Intrinsic restrictions imposed by prematurity did not seem to have impaired reaching performance of preterm infants throughout the months of age.

  9. Gradual reforms and the emergence of energy market in China: Evidence from tests for convergence of energy prices

    International Nuclear Information System (INIS)

    Ma Hengyun; Oxley, Les; Gibson, John

    2009-01-01

    This study investigates the emergence of energy markets by testing for convergence of energy prices with a new dataset on energy spot prices in 35 major cities in China. Both descriptive statistics and unit root are employed to test the convergence of energy prices for each of four fuel price series. The whole study period is divided into two sub-periods in order to reconcile the gradual energy reforms. The results show the steady improvement in energy market performance in China, especially during the second sub-period, which suggests that the market appears to be playing an increasing role in determining energy prices. While panel unit root tests show energy markets are integrated in China as a whole, city-by-city univariate unit root tests suggest that there are still many regional energy markets, probably because energy reserves (especially coal) vary widely across regions. Since China's energy economy is gradually moving towards market-oriented mechanisms, the existing literature may become obsolete soon.

  10. Causal correlations between genes and linguistic features: The mechanism of gradual language evolution

    OpenAIRE

    Dediu, D.

    2008-01-01

    The causal correlations between human genetic variants and linguistic (typological) features could represent the mechanism required for gradual, accretionary models of language evolution. The causal link is mediated by the process of cultural transmission of language across generations in a population of genetically biased individuals. The particular case of Tone, ASPM and Microcephalin is discussed as an illustration. It is proposed that this type of genetically-influenced linguistic bias, c...

  11. Dynamic evolution of the source volumes of gradual and impulsive solar flare emissions

    Science.gov (United States)

    Bruner, M. E.; Crannell, C. J.; Goetz, F.; Magun, A.; Mckenzie, D. L.

    1988-01-01

    This study compares flare source volumes inferred from impulsive hard X-rays and microwaves with those derived from density sensitive soft X-ray line ratios in the O VII spectrum. The data for this study were obtained with the SMM Hard X-ray Burst Spectrometer, Earth-based radio observatories, and the SOLEX-B spectrometer on the P78-1 satellite. Data were available for the flares of 1980 April 8, 1980 May 9, and 1981 February 26. The hard X-ray/microwave source volume is determined under the assumption that the same electron temperature or power law index characterizes both the source of hard X-rays and the source of microwaves. The O VII line ratios yield the density and volume of the 2 x 10 to the 6th K plasma. For all three flares, the O VII source volume is found to be smallest at the beginning of the flare, near the time when the impulsive hard X-ray/microwave volume reaches its first maximum. At this time, the O VII volume is three to four orders of magnitude smaller than that inferred from the hard X-ray/microwave analysis. Subsequently, the O VII source volume increases by one or two orders of magnitude then remains almost constant until the end of the flare when it apparently increases again.

  12. Dynamic evolution of the source volumes of gradual and impulsive solar flare emissions

    International Nuclear Information System (INIS)

    Bruner, M.E.; Crannell, C.J.; Goetz, F.; Magun, A.; Mckenzie, D.L.

    1987-12-01

    This study compares flare source volumes inferred from impulsive hard x rays and microwaves with those derived from density sensitive soft x ray line ratios in the O VII spectrum. The data for this study were obtained with the SMM Hard X-Ray Burst Spectrometer, Earth-based radio observatories, and the SOLEX-B spectrometer on the P78-1 satellite. Data were available for the flares of 1980 April 8, 1980 May 9, and 1981 February 26. The hard x ray/microwave source volume is determined under the assumption that the same electron temperature or power law index characterizes both the source of hard x rays and the source of microwaves. The O VII line ratios yield the density and volume of the 2 X 10 to the 6th K plasma. For all three flares, the O VII source volume is found to be smallest at the beginning of the flare, near the time when the impulsive hard x ray/microwave volume reaches its first maximum. At this time, the O VII volume is three to four orders of magnitude smaller than that inferred from the hard x ray/microwave analysis. Subsequently, the O VII source volume increases by one or two orders of magnitude then remains almost constant until the end of the flare when it apparently increases again

  13. Dynamic evolution of the source volumes of gradual and impulsive solar flare emissions

    International Nuclear Information System (INIS)

    Bruner, M.E.; Crannell, C.J.; Goetz, F.; Magun, A.; Mckenzie, D.L.

    1988-01-01

    This study compares flare source volumes inferred from impulsive hard X-rays and microwaves with those derived from density sensitive soft X-ray line ratios in the O VII spectrum. The data for this study were obtained with the SMM Hard X-ray Burst Spectrometer, Earth-based radio observatories, and the SOLEX-B spectrometer on the P78-1 satellite. Data were available for the flares of 1980 April 8, 1980 May 9, and 1981 February 26. The hard X-ray/microwave source volume is determined under the assumption that the same electron temperature or power law index characterizes both the source of hard X-rays and the source of microwaves. The O VII line ratios yield the density and volume of the 2 x 10 to the 6th K plasma. For all three flares, the O VII source volume is found to be smallest at the beginning of the flare, near the time when the impulsive hard X-ray/microwave volume reaches its first maximum. At this time, the O VII volume is three to four orders of magnitude smaller than that inferred from the hard X-ray/microwave analysis. Subsequently, the O VII source volume increases by one or two orders of magnitude then remains almost constant until the end of the flare when it apparently increases again. 29 references

  14. Gradual plasticity alters population dynamics in variable environments: thermal acclimation in the green alga Chlamydomonas reinhartdii.

    Science.gov (United States)

    Kremer, Colin T; Fey, Samuel B; Arellano, Aldo A; Vasseur, David A

    2018-01-10

    Environmental variability is ubiquitous, but its effects on populations are not fully understood or predictable. Recent attention has focused on how rapid evolution can impact ecological dynamics via adaptive trait change. However, the impact of trait change arising from plastic responses has received less attention, and is often assumed to optimize performance and unfold on a separate, faster timescale than ecological dynamics. Challenging these assumptions, we propose that gradual plasticity is important for ecological dynamics, and present a study of the plastic responses of the freshwater green algae Chlamydomonas reinhardtii as it acclimates to temperature changes. First, we show that C. reinhardtii 's gradual acclimation responses can both enhance and suppress its performance after a perturbation, depending on its prior thermal history. Second, we demonstrate that where conventional approaches fail to predict the population dynamics of C. reinhardtii exposed to temperature fluctuations, a new model of gradual acclimation succeeds. Finally, using high-resolution data, we show that phytoplankton in lake ecosystems can experience thermal variation sufficient to make acclimation relevant. These results challenge prevailing assumptions about plasticity's interactions with ecological dynamics. Amidst the current emphasis on rapid evolution, it is critical that we also develop predictive methods accounting for plasticity. © 2018 The Author(s).

  15. Chronic environmental stress enhances tolerance to seasonal gradual warming in marine mussels.

    Directory of Open Access Journals (Sweden)

    Ionan Marigómez

    Full Text Available In global climate change scenarios, seawater warming acts in concert with multiple stress sources, which may enhance the susceptibility of marine biota to thermal stress. Here, the responsiveness to seasonal gradual warming was investigated in temperate mussels from a chronically stressed population in comparison with a healthy one. Stressed and healthy mussels were subjected to gradual temperature elevation for 8 days (1°C per day; fall: 16-24°C, winter: 12-20°C, summer: 20-28°C and kept at elevated temperature for 3 weeks. Healthy mussels experienced thermal stress and entered the time-limited survival period in the fall, became acclimated in winter and exhibited sublethal damage in summer. In stressed mussels, thermal stress and subsequent health deterioration were elicited in the fall but no transition into the critical period of time-limited survival was observed. Stressed mussels did not become acclimated to 20°C in winter, when they experienced low-to-moderate thermal stress, and did not experience sublethal damage at 28°C in summer, showing instead signs of metabolic rate depression. Overall, although the thermal threshold was lowered in chronically stressed mussels, they exhibited enhanced tolerance to seasonal gradual warming, especially in summer. These results challenge current assumptions on the susceptibility of marine biota to the interactive effects of seawater warming and pollution.

  16. REACH: impact on the US cosmetics industry?

    Science.gov (United States)

    Pouillot, Anne; Polla, Barbara; Polla, Ada

    2009-03-01

    The Registration, Evaluation, Authorization and restriction of Chemicals (REACH) is a recent European regulation on chemical substances meant to protect human health and the environment. REACH imposes the "precautionary principle" where additional data and definitive action are required when uncertainty is identified. The cosmetics industry is only partially concerned by REACH: while the stages of registration and evaluation apply to cosmetics, those of authorization and restriction most likely will not, as cosmetic ingredients are already subject to regulation by various agencies and directives. REACH has potential benefits to the industry including the possibility of reassuring consumers and improving their image of chemicals and cosmetics. However, REACH also has potential disadvantages, mainly with regard to impeding innovation. The American cosmetics industry will be affected by REACH, because all US manufacturers who export substances to Europe will have to fully comply with REACH.

  17. Gradual adaptation to salt and dissolved oxygen: Strategies to minimize adverse effect of salinity on aerobic granular sludge

    KAUST Repository

    Wang, Zhongwei; van Loosdrecht, Mark C.M.; Saikaly, Pascal

    2017-01-01

    Salinity can affect the performance of biological wastewater treatment in terms of nutrient removal. The effect of salt on aerobic granular sludge (AGS) process in terms of granulation and nutrient removal was examined in this study. Experiments were conducted to evaluate the effect of salt (15 g/L NaCl) on granule formation and nutrient removal in AGS system started with flocculent sludge and operated at DO of 2.5 mg/L (phase I). In addition, experiments were conducted to evaluate the effect of gradually increasing the salt concentration (2.5 g/L to 15 g/L NaCl) or increasing the DO level (2.5 mg/L to 8 mg/L) on nutrient removal in AGS system started with granular sludge (phase II) taken from an AGS reactor performing well in terms of N and P removal. Although the addition of salt in phase I did not affect the granulation process, it significantly affected nutrient removal due to inhibition of ammonia oxidizing bacteria (AOB) and phosphate accumulating organisms (PAOs). Increasing the DO to 8 mg/L or adapting granules by gradually increasing the salt concentration minimized the adverse effect of salt on nitrification (phase II). However, these strategies were not successful for mitigating the effect of salt on biological phosphorus removal. No nitrite accumulation occurred in all the reactors suggesting that inhibition of biological phosphorus removal was not due to the accumulation of nitrite as previously reported. Also, glycogen accumulating organisms were shown to be more tolerant to salt than PAO II, which was the dominant PAO clade detected in this study. Future studies comparing the salinity tolerance of different PAO clades are needed to further elucidate the effect of salt on PAOs.

  18. Gradual adaptation to salt and dissolved oxygen: Strategies to minimize adverse effect of salinity on aerobic granular sludge

    KAUST Repository

    Wang, Zhongwei

    2017-08-13

    Salinity can affect the performance of biological wastewater treatment in terms of nutrient removal. The effect of salt on aerobic granular sludge (AGS) process in terms of granulation and nutrient removal was examined in this study. Experiments were conducted to evaluate the effect of salt (15 g/L NaCl) on granule formation and nutrient removal in AGS system started with flocculent sludge and operated at DO of 2.5 mg/L (phase I). In addition, experiments were conducted to evaluate the effect of gradually increasing the salt concentration (2.5 g/L to 15 g/L NaCl) or increasing the DO level (2.5 mg/L to 8 mg/L) on nutrient removal in AGS system started with granular sludge (phase II) taken from an AGS reactor performing well in terms of N and P removal. Although the addition of salt in phase I did not affect the granulation process, it significantly affected nutrient removal due to inhibition of ammonia oxidizing bacteria (AOB) and phosphate accumulating organisms (PAOs). Increasing the DO to 8 mg/L or adapting granules by gradually increasing the salt concentration minimized the adverse effect of salt on nitrification (phase II). However, these strategies were not successful for mitigating the effect of salt on biological phosphorus removal. No nitrite accumulation occurred in all the reactors suggesting that inhibition of biological phosphorus removal was not due to the accumulation of nitrite as previously reported. Also, glycogen accumulating organisms were shown to be more tolerant to salt than PAO II, which was the dominant PAO clade detected in this study. Future studies comparing the salinity tolerance of different PAO clades are needed to further elucidate the effect of salt on PAOs.

  19. Validity of an Interactive Functional Reach Test.

    Science.gov (United States)

    Galen, Sujay S; Pardo, Vicky; Wyatt, Douglas; Diamond, Andrew; Brodith, Victor; Pavlov, Alex

    2015-08-01

    Videogaming platforms such as the Microsoft (Redmond, WA) Kinect(®) are increasingly being used in rehabilitation to improve balance performance and mobility. These gaming platforms do not have built-in clinical measures that offer clinically meaningful data. We have now developed software that will enable the Kinect sensor to assess a patient's balance using an interactive functional reach test (I-FRT). The aim of the study was to test the concurrent validity of the I-FRT and to establish the feasibility of implementing the I-FRT in a clinical setting. The concurrent validity of the I-FRT was tested among 20 healthy adults (mean age, 25.8±3.4 years; 14 women). The Functional Reach Test (FRT) was measured simultaneously by both the Kinect sensor using the I-FRT software and the Optotrak Certus(®) 3D motion-capture system (Northern Digital Inc., Waterloo, ON, Canada). The feasibility of implementing the I-FRT in a clinical setting was assessed by performing the I-FRT in 10 participants with mild balance impairments recruited from the outpatient physical therapy clinic (mean age, 55.8±13.5 years; four women) and obtaining their feedback using a NASA Task Load Index (NASA-TLX) questionnaire. There was moderate to good agreement between FRT measures made by the two measurement systems. The greatest agreement between the two measurement system was found with the Kinect sensor placed at a distance of 2.5 m [intraclass correlation coefficient (2,k)=0.786; PNASA/TLX questionnaire. FRT measures made using the Kinect sensor I-FRT software provides a valid clinical measure that can be used with the gaming platforms.

  20. Reach-to-grasp movement as a minimization process.

    Science.gov (United States)

    Yang, Fang; Feldman, Anatol G

    2010-02-01

    It is known that hand transport and grasping are functionally different but spatially coordinated components of reach-to-grasp (RTG) movements. As an extension of this notion, we suggested that body segments involved in RTG movements are controlled as a coherent ensemble by a global minimization process associated with the necessity for the hand to reach the motor goal. Different RTG components emerge following this process without pre-programming. Specifically, the minimization process may result from the tendency of neuromuscular elements to diminish the spatial gap between the actual arm-hand configuration and its virtual (referent) configuration specified by the brain. The referent configuration is specified depending on the object shape, localization, and orientation. Since the minimization process is gradual, it can be interrupted and resumed following mechanical perturbations, at any phase during RTG movements, including hand closure. To test this prediction of the minimization hypothesis, we asked subjects to reach and grasp a cube placed within the reach of the arm. Vision was prevented during movement until the hand returned to its initial position. As predicted, by arresting wrist motion at different points of hand transport in randomly selected trials, it was possible to halt changes in hand aperture at any phase, not only during hand opening but also during hand closure. Aperture changes resumed soon after the wrist was released. Another test of the minimization hypothesis was made in RTG movements to an object placed beyond the reach of the arm. It has previously been shown (Rossi et al. in J Physiol 538:659-671, 2002) that in such movements, the trunk motion begins to contribute to hand transport only after a critical phase when the shifts in the referent arm configuration have finished (at about the time when hand velocity is maximal). The minimization rule suggests that when the virtual contribution of the arm to hand transport is completed

  1. Evaluation of the force generated by gradual deflection of orthodontic wires in conventional metallic, esthetic, and self-ligating brackets.

    Science.gov (United States)

    Francisconi, Manoela Fávaro; Janson, Guilherme; Henriques, José Fernando Castanha; Freitas, Karina Maria Salvatore de

    2016-01-01

    The purpose of this study was to evaluate the deflection forces of Nitinol orthodontic wires placed in different types of brackets: metallic, reinforced polycarbonate with metallic slots, sapphire, passive and active self-ligating, by assessing strength values variation according to gradual increase in wire diameter and deflection and comparing different combinations in the different deflections. Specimens were set in a clinical simulation model and evaluated in a Universal Testing Machine (INSTRON 3342), using the ISO 15841 protocol. Data were subjected to One-way ANOVA, followed by Tukey tests (pbrackets presented the most similar behavior to each other. For conventional brackets there was no consistent behavior for any of the deflections studied. Self-ligating brackets presented the most consistent and predictable results while conventional brackets, as esthetic brackets, showed very different patterns of forces. Self-ligating brackets showed higher strength in all deflections when compared with the others, in 0.020-inch wires.

  2. An arterio-venous bridge for gradual weaning from adult veno-arterial extracorporeal life support.

    Science.gov (United States)

    Babar, Z U D; Sharma, A S; Ganushchak, Y M; Delnoij, T S R; Donker, D W; Maessen, J G; Weerwind, P W

    2015-11-01

    Weaning from extracorporeal life support (ELS) is particularly challenging when cardiac recovery is slow, largely incomplete and hard to predict. Therefore, we describe an individualized gradual weaning strategy using an arterio-venous (AV) bridge incorporated into the circuit to facilitate weaning. Thirty adult patients weaned from veno-arterial ELS using an AV bridge were retrospectively analyzed. Serial echocardiography and hemodynamic monitoring were used to assess cardiac recovery and load responsiveness. Upon early signs of myocardial recovery, an AV bridge with an Hoffman clamp was added to the circuit and weaning was initiated. Support flow was reduced stepwise by 10-15% every 2 to 8 hours while the circuit flow was maintained at 3.5-4.5 L/min. The AV bridge facilitated gradual weaning in all 30 patients (median age: 66 [53-71] years; 21 males) over a median period of 25 [8-32] hours, with a median support duration of 96 [31-181] hours. During weaning, the median left ventricular ejection fraction was 25% [15-32] and the median velocity time integral of the aortic valve was 16 cm [10-23]. Through the weaning period, the mean arterial blood pressure was maintained at 70 mmHg and the activated partial thromboplastin time was 60 ± 10 seconds without additional systemic heparinization. Neither macroscopic thrombus formation in the ELS circuit during and after weaning nor clinically relevant thromboembolism was observed. Incorporation of an AV bridge for weaning from veno-arterial ELS is safe and feasible to gradually wean patients with functional cardiac recovery without compromising the circuit integrity. © The Author(s) 2015.

  3. The Dependence of Characteristic Times of Gradual SEP Events on Their Associated CME Properties

    Science.gov (United States)

    Pan, Z. H.; Wang, C. B.; Xue, X. H.; Wang, Y. M.

    It is generally believed that coronal mass ejections CMEs are the drivers of shocks that accelerate gradual solar energetic particles SEPs One might expect that the characteristics of the SEP intensity time profiles observed at 1 AU are determined by properties of the associated CMEs such as the radial speed and the angular width Recently Kahler statistically investigated the characteristic times of gradual SEP events observed from 1998-2002 and their associated coronal mass ejection properties Astrophys J 628 1014--1022 2005 Three characteristic times of gradual SEP events are determined as functions of solar source longitude 1 T 0 the time from associated CME launch to SEP onset at 1 AU 2 T R the rise time from SEP onset to the time when the SEP intensity is a factor of 2 below peak intensity and 3 T D the duration over which the SEP intensity is within a factor of 2 of the peak intensity However in his study the CME speeds and angular widths are directly taken from the LASCO CME catalog In this study we analyze the radial speeds and the angular widths of CMEs by an ice-cream cone model and re-investigate their correlationships with the characteristic times of the corresponding SEP events We find T R and T D are significantly correlated with radial speed for SEP events in the best-connected longitude range and there is no correlation between T 0 and CME radial speed and angular width which is consistent with Kahler s results On the other hand it s found that T R and T D are also have

  4. Direct ethanol solid oxide fuel cell operating in gradual internal reforming

    Science.gov (United States)

    Nobrega, S. D.; Galesco, M. V.; Girona, K.; de Florio, D. Z.; Steil, M. C.; Georges, S.; Fonseca, F. C.

    2012-09-01

    An electrolyte supported solid oxide fuel cell (SOFC) using standard electrodes, doped-lanthanum manganite cathode and Ni-cermet anode, was operated with direct (anhydrous) ethanol for more than 100 h, delivering essentially the same power output as running on hydrogen. A ceria-based layer provides the catalytic activity for the gradual internal reforming, which uses the steam formed by the electrochemical oxidation of hydrogen for the decomposition of ethanol. Such a concept opens up the way for multi-fuel SOFCs using standard components and a catalytic layer.

  5. Social representations of climate change in Swedish lay focus groups: local or distant, gradual or catastrophic?

    Science.gov (United States)

    Wibeck, Victoria

    2014-02-01

    This paper explores social representations of climate change, investigating how climate change is discussed by Swedish laypeople interacting in focus group interviews. The analysis focuses on prototypical examples and metaphors, which were key devices for objectifying climate change representations. The paper analyzes how the interaction of focus group participants with other speakers, ideas, arguments, and broader social representations shaped their representations of climate change. Climate change was understood as a global but distant issue with severe consequences. There was a dynamic tension between representations of climate change as a gradual vs. unpredictable process. Implications for climate change communication are discussed.

  6. A Cost-based Explanation of Gradual, Regional Internationalization of Multinationals on Social Networking Sites

    DEFF Research Database (Denmark)

    Pogrebnyakov, Nicolai

    2017-01-01

    This paper examines firm internationalization on social networking sites (SNS). It systematically examines costs faced by an internationalizing firm and how firms react to these costs according to “distance-dependent” (gradual and regional) and “distance-invariant” (born-global) explanations...... of internationalization. Data on 5827 country pages of 240 multinational firms on Facebook, the most popular SNS today, is used. Creating a foreign country-specific Facebook page is considered the SNS equivalent of opening a physical subsidiary in that country. The data show that multinationals exhibit...

  7. La abstracción de datos y su proceso gradual de construcción

    OpenAIRE

    MORENO, FRANCISCO; ECHEVERRI, JAIME; FLÓREZ, ROBERTO

    2008-01-01

    En este artículo se presenta el proceso gradual de construcción de tipos abstractos de datos (TADs), como los Fraccionarios y los Polinomios, a partir de TADs esenciales, como los Lógicos y los Enteros. Se propone un conjunto de categorías funcionales para clasificar las funciones de un TAD. Las funciones se especifican mediante programación funcional, es decir, no se utilizan construcciones estructuradas como la asignación, la secuencia y los ciclos. Hasta ahora no se encuentra r...

  8. Engineering web maps with gradual content zoom based on streaming vector data

    Science.gov (United States)

    Huang, Lina; Meijers, Martijn; Šuba, Radan; van Oosterom, Peter

    2016-04-01

    Vario-scale data structures have been designed to support gradual content zoom and the progressive transfer of vector data, for use with arbitrary map scales. The focus to date has been on the server side, especially on how to convert geographic data into the proposed vario-scale structures by means of automated generalisation. This paper contributes to the ongoing vario-scale research by focusing on the client side and communication, particularly on how this works in a web-services setting. It is claimed that these functionalities are urgently needed, as many web-based applications, both desktop and mobile, require gradual content zoom, progressive transfer and a high performance level. The web-client prototypes developed in this paper make it possible to assess the behaviour of vario-scale data and to determine how users will actually see the interactions. Several different options of web-services communication architectures are possible in a vario-scale setting. These options are analysed and tested with various web-client prototypes, with respect to functionality, ease of implementation and performance (amount of transmitted data and response times). We show that the vario-scale data structure can fit in with current web-based architectures and efforts to standardise map distribution on the internet. However, to maximise the benefits of vario-scale data, a client needs to be aware of this structure. When a client needs a map to be refined (by means of a gradual content zoom operation), only the 'missing' data will be requested. This data will be sent incrementally to the client from a server. In this way, the amount of data transferred at one time is reduced, shortening the transmission time. In addition to these conceptual architecture aspects, there are many implementation and tooling design decisions at play. These will also be elaborated on in this paper. Based on the experiments conducted, we conclude that the vario-scale approach indeed supports gradual

  9. REACH: Evaluation Report and Executive Summary

    Science.gov (United States)

    Sibieta, Luke

    2016-01-01

    REACH is a targeted reading support programme designed to improve reading accuracy and comprehension in pupils with reading difficulties in Years 7 and 8. It is based on research by the Centre for Reading and Language at York and is delivered by specially trained teaching assistants (TAs). This evaluation tested two REACH interventions, one based…

  10. Study on FPGA-Based Emulator for the Diagnosis of Gradual Degradation in Reciprocating Pump

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Sun; Kim, Wooshik [Sejong Univ., Seoul (Korea, Republic of); Kim, Tae Yun; Chai, Jang Bom [Ajou Univ., Suwon (Korea, Republic of)

    2017-01-15

    The purpose of this study is to develop a method for diagnosing the degree of gradual degradation of a reciprocating pump caused by continuous use as a water supply pump in a nuclear power plant. Normally, the progress of such degradation is too slow to be noticed. Hence, it is difficult to determine the degree of degradation using the existing diagnostic methods. In this paper, we propose a new method by which the normal state and the degraded state of the pump can be differentiated, so that the degree of degradation can be identified. First, an emulator was developed using FPGA by providing the parameters of the pump under normal state, so that the emulator generates the information of the pump in the healthy state. Then, by comparing this information with the parameters received from various output sensors of the emulator during the current state, it is possible to identify and measure the degree of gradual degradation. This paper presents some of the results obtained during the development process, and results that show how the emulator operates, by comparing the data collected from an actual pump.

  11. Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions

    International Nuclear Information System (INIS)

    Uriu, Koichiro; Ares, Saúl; Oates, Andrew C; Morelli, Luis G

    2012-01-01

    Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. (paper)

  12. Gradual nerve elongation affects nerve cell bodies and neuro-muscular junctions.

    Science.gov (United States)

    Kazuo Ikeda, K I; Masaki Matsuda, M M; Daisuke Yamauchi, D Y; Katsuro Tomita, K T; Shigenori Tanaka, S T

    2005-07-01

    The purpose of this study is to clarify the reactions of the neuro-muscular junction and nerve cell body to gradual nerve elongation. The sciatic nerves of Japanese white rabbits were lengthened by 30 mm in increments of 0.8 mm/day, 2.0 mm/day and 4.0 mm/day. A scanning electron microscopic examination showed no degenerative change at the neuro-muscular junction, even eight weeks after elongation in the 4-mm group. Hence, neuro-muscular junction is not critical for predicting damage from gradual nerve elongation. There were no axon reaction cells in the 0.8-mm group, a small amount in the 2-mm group, and a large amount in the 4-mm group. The rate of growth associated protein-43 positive nerve cells was significant in the 4-mm group. Hence, the safe speed for nerve cells appeared to be 0.8-mm/day, critical speed to be 2.0-mm/day, and dangerous speed to be 4.0-mm/day in this elongation model.

  13. Finding common ground in implementation: towards a theory of gradual commonality.

    Science.gov (United States)

    Ter Haar, Marian; Aarts, Noelle; Verhoeven, Piet

    2016-03-01

    This article reports on an empirical study that aimed to design a practice-based theory about collaboration on the local implementation of a nationally developed health-promoting intervention. The study's objective is to better understand the dynamic process of complex collaboration. The research is based on a Delphi study among some 100 individuals in local and regional networks, in which various professionals work together to implement the BeweegKuur, which translates as 'course of exercise'. The BeweegKuur is a combined lifestyle intervention aimed at promoting sufficient physical exercise and a healthy diet among people in the Netherlands who are overweight and at risk of diabetes. The Delphi study in three rounds systematically and interactively constructs a common perspective on implementation, reflecting stakeholders' ideas about the collaboration and providing an insight into how these ideas are influenced by the context of the implementation. The statistical and qualitative analyses of the responses to the feedback in the Delphi study form the basis for this practice-based theory on complex collaboration, called the theory of gradual commonality. During interaction, consensus gradually emerges about co-creation as a collaboration strategy. Co-creation leaves room for various ways of achieving the ambitions of the BeweegKuur. This article discusses the importance of this practice-based theory and the value of the Delphi research strategy for promoting health. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Enhanced Attention to Speaking Faces Versus Other Event Types Emerges Gradually Across Infancy

    Science.gov (United States)

    Bahrick, Lorraine E.; Todd, James Torrence; Castellanos, Irina; Sorondo, Barbara M.

    2017-01-01

    The development of attention to dynamic faces vs. objects providing synchronous audiovisual vs. silent visual stimulation was assessed in a large sample of infants. Maintaining attention to the faces and voices of people speaking is critical for perceptual, cognitive, social, and language development. However, no studies have systematically assessed when, if, or how attention to speaking faces emerges and changes across infancy. Two measures of attention maintenance, habituation time (HT) and look-away rate (LAR), were derived from cross-sectional data of 2- to 8-month-old infants (N = 801). Results indicated that attention to audiovisual faces and voices was maintained across age, whereas attention to each of the other event types (audiovisual objects, silent dynamic faces, silent dynamic objects) declined across age. This reveals a gradually emerging advantage in attention maintenance (longer habituation times, lower look-away rates) for audiovisual speaking faces compared with the other three event types. At 2 months, infants showed no attentional advantage for faces (with greater attention to audiovisual than to visual events), at 3 months, they attended more to dynamic faces than objects (in the presence or absence of voices), and by 4 to 5 and 6 to 8 months significantly greater attention emerged to temporally coordinated faces and voices of people speaking compared with all other event types. Our results indicate that selective attention to coordinated faces and voices over other event types emerges gradually across infancy, likely as a function of experience with multimodal, redundant stimulation from person and object events. PMID:27786526

  15. A laboratory experiment on the evolution of a sand gravel reach under a lack of sediment supply

    NARCIS (Netherlands)

    Orru, C.; Chavarrias Borras, V.; Ferrara, V.; Stecca, G.; Blom, A.

    2015-01-01

    A flume experiment was conducted to examine the evolution of a sand-gravel reach under a lack of sediment supply. A bed composed of a bimodal sediment mixture was installed with a uniform slope and an gradual fining pattern. At the upstream end of the flume the initial bed consisted of 100% gravel,

  16. The database for reaching experiments and models.

    Directory of Open Access Journals (Sweden)

    Ben Walker

    Full Text Available Reaching is one of the central experimental paradigms in the field of motor control, and many computational models of reaching have been published. While most of these models try to explain subject data (such as movement kinematics, reaching performance, forces, etc. from only a single experiment, distinct experiments often share experimental conditions and record similar kinematics. This suggests that reaching models could be applied to (and falsified by multiple experiments. However, using multiple datasets is difficult because experimental data formats vary widely. Standardizing data formats promises to enable scientists to test model predictions against many experiments and to compare experimental results across labs. Here we report on the development of a new resource available to scientists: a database of reaching called the Database for Reaching Experiments And Models (DREAM. DREAM collects both experimental datasets and models and facilitates their comparison by standardizing formats. The DREAM project promises to be useful for experimentalists who want to understand how their data relates to models, for modelers who want to test their theories, and for educators who want to help students better understand reaching experiments, models, and data analysis.

  17. Changes in ultraviolet radiation reaching the earth's surface

    International Nuclear Information System (INIS)

    Madronich, S.; McKenzie, R.L.; Caldwell, M.M.; Bjorn, L.O.

    1995-01-01

    The quality and quantity of UV measurements have increased greatly in the last few years. Variations among measurements from different instruments are diminishing toward the 5 level. Long-term trend detection is still a problem, with little historical data available for baseline estimations. Enhanced UV levels are clearly associated with the antartic springtime ozone reductions. Measurements show that maximum UV levels at the South Pole are reached well before the summer solstice, and DNA-damaging radiation at Palmer Station, Antarctica (64§S) during the springtime ozone depletion can exceed maximum summer values at San Diego, USA (32§N). UV increases al mid-latitudes are smaller. However, increases associated with the record low ozone column of 1992-93 in the Northern Hemisphere are evident when examined on a wavelength-specific basis. Measurements in Argentina, Chile, New Zealand, and Australia show relatively high spheric latitudes, with differences in both stratospheric ozone and tropospheric pollutants likely to be playing a role. Tropospheric ozone and aerosols can reduce global UV-B irradiances appreciably. At some locations, tropospheric pollution has increased since pre-industrial times, leading to decreases in surface UV radiation. However, recent trends in tropospheric pollution probably had only minor effects on UV trends relative to the effect of stratospheric ozone reductions. Global ozone measurements from satellites over the period 1979-1993 imply significant UV-B increases at high and mid-latitudes of both hemispheres, but only small changes in the tropics. Such estimates however assume that cloud cover and tropospheric pollution have remained constant over this time period. Under the current CFC phase-out schedules, global UV levels are predicted to peak around the turn of the century in association with peak loading of chlorine in the stratosphere and the concomitant ozone reductions. The recovery to pre-ozone depletion levels is expected to

  18. The learning of sciences: a gradual change in the way of learning. The case of vision

    Directory of Open Access Journals (Sweden)

    Bettina M. Bravo

    2009-11-01

    Full Text Available Learning the scientific way of knowledge implies a change in the most implicit principles that guide comprehension, interpretation and explanation of scientific phenomena as well as a change in the type of associated reasoning. With the aim of favouring this type of learning, a teaching programme was developed in relation to vision and implemented with a group of secondary school students. The way of learning of these students was observed at different teaching stages. Findings suggest that during the learning process the way students learn seems to change gradually and that students construct “intermediate” models (right but incomplete that become the basis for the construction of a systemic model proposed by school science.

  19. Automated choroid segmentation based on gradual intensity distance in HD-OCT images.

    Science.gov (United States)

    Chen, Qiang; Fan, Wen; Niu, Sijie; Shi, Jiajia; Shen, Honglie; Yuan, Songtao

    2015-04-06

    The choroid is an important structure of the eye and plays a vital role in the pathology of retinal diseases. This paper presents an automated choroid segmentation method for high-definition optical coherence tomography (HD-OCT) images, including Bruch's membrane (BM) segmentation and choroidal-scleral interface (CSI) segmentation. An improved retinal nerve fiber layer (RNFL) complex removal algorithm is presented to segment BM by considering the structure characteristics of retinal layers. By analyzing the characteristics of CSI boundaries, we present a novel algorithm to generate a gradual intensity distance image. Then an improved 2-D graph search method with curve smooth constraints is used to obtain the CSI segmentation. Experimental results with 212 HD-OCT images from 110 eyes in 66 patients demonstrate that the proposed method can achieve high segmentation accuracy. The mean choroid thickness difference and overlap ratio between our proposed method and outlines drawn by experts was 6.72µm and 85.04%, respectively.

  20. Gradual cut detection using low-level vision for digital video

    Science.gov (United States)

    Lee, Jae-Hyun; Choi, Yeun-Sung; Jang, Ok-bae

    1996-09-01

    Digital video computing and organization is one of the important issues in multimedia system, signal compression, or database. Video should be segmented into shots to be used for identification and indexing. This approach requires a suitable method to automatically locate cut points in order to separate shot in a video. Automatic cut detection to isolate shots in a video has received considerable attention due to many practical applications; our video database, browsing, authoring system, retrieval and movie. Previous studies are based on a set of difference mechanisms and they measured the content changes between video frames. But they could not detect more special effects which include dissolve, wipe, fade-in, fade-out, and structured flashing. In this paper, a new cut detection method for gradual transition based on computer vision techniques is proposed. And then, experimental results applied to commercial video are presented and evaluated.

  1. Gradual caldera collapse at Bárdarbunga volcano, Iceland, regulated by lateral magma outflow.

    Science.gov (United States)

    Gudmundsson, Magnús T; Jónsdóttir, Kristín; Hooper, Andrew; Holohan, Eoghan P; Halldórsson, Sæmundur A; Ófeigsson, Benedikt G; Cesca, Simone; Vogfjörd, Kristín S; Sigmundsson, Freysteinn; Högnadóttir, Thórdís; Einarsson, Páll; Sigmarsson, Olgeir; Jarosch, Alexander H; Jónasson, Kristján; Magnússon, Eyjólfur; Hreinsdóttir, Sigrún; Bagnardi, Marco; Parks, Michelle M; Hjörleifsdóttir, Vala; Pálsson, Finnur; Walter, Thomas R; Schöpfer, Martin P J; Heimann, Sebastian; Reynolds, Hannah I; Dumont, Stéphanie; Bali, Eniko; Gudfinnsson, Gudmundur H; Dahm, Torsten; Roberts, Matthew J; Hensch, Martin; Belart, Joaquín M C; Spaans, Karsten; Jakobsson, Sigurdur; Gudmundsson, Gunnar B; Fridriksdóttir, Hildur M; Drouin, Vincent; Dürig, Tobias; Aðalgeirsdóttir, Guðfinna; Riishuus, Morten S; Pedersen, Gro B M; van Boeckel, Tayo; Oddsson, Björn; Pfeffer, Melissa A; Barsotti, Sara; Bergsson, Baldur; Donovan, Amy; Burton, Mike R; Aiuppa, Alessandro

    2016-07-15

    Large volcanic eruptions on Earth commonly occur with a collapse of the roof of a crustal magma reservoir, forming a caldera. Only a few such collapses occur per century, and the lack of detailed observations has obscured insight into the mechanical interplay between collapse and eruption. We use multiparameter geophysical and geochemical data to show that the 110-square-kilometer and 65-meter-deep collapse of Bárdarbunga caldera in 2014-2015 was initiated through withdrawal of magma, and lateral migration through a 48-kilometers-long dike, from a 12-kilometers deep reservoir. Interaction between the pressure exerted by the subsiding reservoir roof and the physical properties of the subsurface flow path explain the gradual, near-exponential decline of both collapse rate and the intensity of the 180-day-long eruption. Copyright © 2016, American Association for the Advancement of Science.

  2. La abstracción de datos y su proceso gradual de construcción

    Directory of Open Access Journals (Sweden)

    FRANCISCO MORENO

    2008-01-01

    Full Text Available En este artículo se presenta el proceso gradual de construcción de tipos abstractos de datos (TADs, como los Fraccionarios y los Polinomios, a partir de TADs esenciales, como los Lógicos y los Enteros. Se propone un conjunto de categorías funcionales para clasificar las funciones de un TAD. Las funciones se especifican mediante programación funcional, es decir, no se utilizan construcciones estructuradas como la asignación, la secuencia y los ciclos. Hasta ahora no se encuentra reportada la especificación de funciones con programación funcional para la simplificación en el TAD de los Enteros ni para la suma ordenada en el TAD de los polinomios. Además se muestra la relación inherente entre las funciones de un TAD y la sobrecarga de operadores.

  3. An evolutionary perspective on gradual formation of superego in the primal horde

    Directory of Open Access Journals (Sweden)

    Erdem ePulcu

    2014-01-01

    Full Text Available Freud proposed that the processes which occurred in the primal horde are essential for understanding superego formation and therefore, the successful dissolution of the Oedipus complex. However, Freud theorized superego formation in the primal horde as if it is an instant, all-or-none achievement. The present paper proposes an alternative model aiming to explain gradual development of superego in the primitive man. The proposed model is built on knowledge from evolutionary and neural sciences as well as anthropology, and it particularly focuses on the evolutionary significance of the acquisition of fire by hominids in the Pleistocene period in the light of archaeological findings. Acquisition of fire is discussed as a form of sublimation which might have helped Prehistoric man to maximise the utility of limited evolutionary biological resources, potentially contributing to the rate and extent of bodily evolution. The limitations of both Freud's original conceptualisation and the present model are discussed accordingly in an interdisciplinary framework.

  4. Enhancing US Operational Reach in Southeast Asia

    National Research Council Canada - National Science Library

    Hitchcock, David

    2003-01-01

    .... While this treat continues to exist, the US Pacific Command (PACOM) must also pursue a neat term methodology to expand its operational reach and ability to respond to contingencies throughout the East Asian littoral, especially within Southeast Asia...

  5. Reaching the Overlooked Student in Physical Education

    Science.gov (United States)

    Esslinger, Keri; Esslinger, Travis; Bagshaw, Jarad

    2015-01-01

    This article describes the use of live action role-playing, or "LARPing," as a non-traditional activity that has the potential to reach students who are not interested in traditional physical education.

  6. Compact muon solenoid magnet reaches full field

    CERN Multimedia

    2006-01-01

    Scientist of the U.S. Department of Energy in Fermilab and collaborators of the US/CMS project announced that the world's largest superconducting solenoid magnet has reached full field in tests at CERN. (1 apge)

  7. Swarm of bees and particles algorithms in the problem of gradual failure reliability assurance

    Directory of Open Access Journals (Sweden)

    M. F. Anop

    2015-01-01

    Full Text Available Probability-statistical framework of reliability theory uses models based on the chance failures analysis. These models are not functional and do not reflect relation of reliability characteristics to the object performance. At the same time, a significant part of the technical systems failures are gradual failures caused by degradation of the internal parameters of the system under the influence of various external factors.The paper shows how to provide the required level of reliability at the design stage using a functional model of a technical object. Paper describes the method for solving this problem under incomplete initial information, when there is no information about the patterns of technological deviations and degradation parameters, and the considered system model is a \\black box" one.To this end, we formulate the problem of optimal parametric synthesis. It lies in the choice of the nominal values of the system parameters to satisfy the requirements for its operation and take into account the unavoidable deviations of the parameters from their design values during operation. As an optimization criterion in this case we propose to use a deterministic geometric criterion \\reliability reserve", which is the minimum distance measured along the coordinate directions from the nominal parameter value to the acceptability region boundary rather than statistical values.The paper presents the results of the application of heuristic swarm intelligence methods to solve the formulated optimization problem. Efficiency of particle swarm algorithms and swarm of bees one compared with undirected random search algorithm in solving a number of test optimal parametric synthesis problems in three areas: reliability, convergence rate and operating time. The study suggests that the use of a swarm of bees method for solving the problem of the technical systems gradual failure reliability ensuring is preferred because of the greater flexibility of the

  8. Experimental and numerical investigation of the flow field in the gradual transition of rectangular to trapezoidal open channels

    Directory of Open Access Journals (Sweden)

    Adel Asnaashari

    2016-01-01

    Full Text Available Transitions are structures that can change geometry and flow velocity through varying the cross-sections of their channels. Under subcritical flow and steady flow conditions, it is necessary to reduce the flow velocity gradually due to increasing water pressure and adverse pressure gradients. Due to the separation of flow and subsequent eddy formation, a significant energy loss is incurred along the transition. This study presents the results of experimental investigations of the subcritical flow along the expansive transition of rectangular to trapezoidal channels. A numerical simulation was developed using a finite volume of fluid (VOF method with a Reynolds stress turbulence model. Water surface profiles and velocity distributions of flow through the transition were measured experimentally and compared with the numerical results. A good agreement between the experimental and numerical model results showed that the Reynolds model and VOF method are capable of simulating the hydraulic flow in open channel transitions. Also, the efficiency of the transition and coefficient of energy head loss were calculated. The results show that with an increasing upstream Froude number, the efficiency of the transition and coefficient of energy head loss decrease and increase, respectively. The results also show the ability of numerical simulation to simulate the flow separation zones and secondary current along the transition for different inlet discharges.

  9. When Does the Warmest Water Reach Greenland?

    Science.gov (United States)

    Grist, J. P.; Josey, S. A.; Boehme, L.; Meredith, M. P.; Laidre, K. L.; Heide-Jørgensen, M. P.; Kovacs, K. M.; Lydersen, C.; Davidson, F. J. M.; Stenson, G. B.; Hammill, M. O.; Marsh, R.; Coward, A.

    2016-02-01

    The warmest water reaching the east and west coast of Greenland is found between 200 and 600 m, in the warm Atlantic Water Layer (WL). Temperature changes within the WL have been highlighted as a possible cause of accelerated melting of tidewater glaciers and therefore are an important consideration for understanding global sea level rise. However, a limited number of winter observations of the WL have prohibited determining its seasonal variability. To address this, temperature data from Argo profiling floats, a range of sources within the World Ocean Database, and unprecedented coverage from marine-mammal borne sensors have been analyzed for the period 2002-2011. A significant seasonal range in temperature ( 1-2°C) is found in the warm layer, in contrast to most of the surrounding ocean. The magnitude of the seasonal cycle is thus comparable with the 1990s warming that was associated with an increased melt rate in a marine terminating glacier of West Greenland. The phase of the seasonal cycle exhibits considerable spatial variability; with high-resolution ocean model trajectory analysis suggesting it is determined by the time taken for waters to be advected from the subduction site in the Irminger Basin. For western Greenland, the annual temperature maximum occurs near or after the turn of the calendar year. This is significant because a recent study suggested that it is in the non-summer months when fjord-shelf exchanges allow the WL to most strongly influence glacier melt rate. However this is also the time of the year when the WL is least well observed. It is therefore clear that year-round subsurface temperature measurements are still required for a complete description of the WL seasonality, and in particular to ensure that the ice-melting potential of the WL is not underestimated.

  10. Do working environment interventions reach shift workers?

    Science.gov (United States)

    Nabe-Nielsen, Kirsten; Jørgensen, Marie Birk; Garde, Anne Helene; Clausen, Thomas

    2016-01-01

    Shift workers are exposed to more physical and psychosocial stressors in the working environment as compared to day workers. Despite the need for targeted prevention, it is likely that workplace interventions less frequently reach shift workers. The aim was therefore to investigate whether the reach of workplace interventions varied between shift workers and day workers and whether such differences could be explained by the quality of leadership exhibited at different times of the day. We used questionnaire data from 5361 female care workers in the Danish eldercare sector. The questions concerned usual working hours, quality of leadership, and self-reported implementation of workplace activities aimed at stress reduction, reorganization of the working hours, and participation in improvements of working procedures or qualifications. Compared with day workers, shift workers were less likely to be reached by workplace interventions. For example, night workers less frequently reported that they had got more flexibility (OR 0.5; 95 % CI 0.3-0.7) or that they had participated in improvements of the working procedures (OR 0.6; 95 % CI 0.5-0.8). Quality of leadership to some extent explained the lack of reach of interventions especially among fixed evening workers. In the light of the evidence of shift workers' stressful working conditions, we suggest that future studies focus on the generalizability of results of the present study and on how to reach this group and meet their needs when designing and implementing workplace interventions.

  11. Guiding Warfare to Reach Sustainable Peace

    DEFF Research Database (Denmark)

    Vestenskov, David; Drewes, Line

    The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition of develo......The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition...... of developing best practices in the education and implementation of IHL in capacity building of security forces....

  12. Do working environment interventions reach shift workers?

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Jørgensen, Marie Birk; Garde, Anne Helene

    2016-01-01

    PURPOSE: Shift workers are exposed to more physical and psychosocial stressors in the working environment as compared to day workers. Despite the need for targeted prevention, it is likely that workplace interventions less frequently reach shift workers. The aim was therefore to investigate whether...... the reach of workplace interventions varied between shift workers and day workers and whether such differences could be explained by the quality of leadership exhibited at different times of the day. METHODS: We used questionnaire data from 5361 female care workers in the Danish eldercare sector...

  13. Invisibility cloaks with arbitrary geometries for layered and gradually changing backgrounds

    International Nuclear Information System (INIS)

    Li, C; Yao, K; Li, F

    2009-01-01

    Cloaks with arbitrary geometries are proposed which can make objects invisible in inhomogeneous backgrounds. The general and explicit expressions of the complex permittivity and permeability tensors are derived for cloaks embedded in layered and gradually changing media. The inner and the outer boundaries of the cloaks can be non-conformal with arbitrary shapes, which considerably improve the flexibility of the cloak applications. The interactions of electromagnetic waves with irregular cloaks are studied based on numerical simulations. The influences of the cloaked and uncloaked perfect electric conductor (PEC) cylinders upon the scattering fields of the multilayered backgrounds are quantitatively evaluated. The effect of loss on the cloaking performance has also been investigated. It is verified that cloaks with ideal parameters can smoothly deflect and guide the incoming beams to propagate around the shielded regions without disturbing the beams when they return to the inhomogeneous backgrounds. Therefore, the objects in the shielded region can be effectively invisible to the corresponding backgrounds. The performance of lossy cloaks will degrade with comparatively large power reduction of the transmitted beams.

  14. Simultaneous Modeling of Gradual SEP Events at the Earth and the Mars

    Science.gov (United States)

    Hu, J.; Li, G.

    2017-12-01

    Solar Energetic Particles (SEP) event is the number one space hazard for spacecraft instruments and astronauts' safety. Recent studies have shown that both longitudinal and radial extent of SEP events can be very significant. In this work, we use the improved Particle Acceleration and Transport in the Heliosphere (iPATH) model to simulate gradual SEP events that have impacts upon both the Earth and the Mars. We follow the propagation of a 2D CME-driven shock. Particles are accelerated at the shock via the diffusive shock acceleration (DSA) mechanism. Transport of the escaped particles to the Earth and the Mars is then followed using a backward stochastic differential equation method. Perpendicular diffusion is considered in both the DSA and the transport process. Model results such as time intensity profile and energetic particle spectrum at the two locations are compared to understand the spatial extent of an SEP event. Observational data at the Earth and the Mars are also studied to validate the model.

  15. Evolutionary characteristics of morbilliviruses during serial passages in vitro: Gradual attenuation of virus virulence.

    Science.gov (United States)

    Liu, Fuxiao; Wu, Xiaodong; Li, Lin; Zou, Yanli; Liu, Shan; Wang, Zhiliang

    2016-08-01

    The genus Morbillivirus is classified into the family Paramyxoviridae, and is composed of 6 members, namely measles virus (MV), rinderpest virus (RPV), peste-des-petits-ruminants virus (PPRV), canine distemper virus (CDV), phocine distemper virus (PDV) and cetacean morbillivirus (CeMV). The MV, RPV, PPRV and CDV have been successfully attenuated through their serial passages in vitro for the production of live vaccines. It has been demonstrated that the morbilliviral virulence in animals was progressively attenuated with their consecutive passages in vitro. However, only a few reports were involved in explanation of an attenuation-related mechanism on them until many years after the establishment of a quasispecies theory. RNA virus quasispecies arise from rapid evolution of viruses with high mutation rate during genomic replication, and play an important role in gradual loss of viral virulence by serial passages. Here, we overviewed the development of live-attenuated vaccine strains against morbilliviruses by consecutive passages in vitro, and further discussed a related mechanism concerning the relationship between virulence attenuation and viral evolution. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Gradual extinction prevents the return of fear: Implications for the discovery of state

    Directory of Open Access Journals (Sweden)

    Samuel Joseph Gershman

    2013-11-01

    Full Text Available Fear memories are notoriously difficult to erase, often recovering over time. The longstanding explanation for this finding is that, in extinction training, a new memory is formed that competes with the old one for expression but does not otherwise modify it. This explanation is at odds with traditional models of learning such as Rescorla-Wagner and reinforcement learning. A possible reconciliation that was recently suggested is that extinction training leads to the inference of a new state that is different from the state that was in effect in the original training. This solution, however, raises a new question: under what conditions are new states, or new memories formed? Theoretical accounts implicate persistent large prediction errors in this process. As a test of this idea, we reasoned that careful design of the reinforcement schedule during extinction training could reduce these prediction errors enough to prevent the formation of a new memory, while still decreasing reinforcement sufficiently to drive modification of the old fear memory. In two Pavlovian fear-conditioning experiments, we show that gradually reducing the frequency of aversive stimuli, rather than eliminating them abruptly, prevents the recovery of fear. This finding has important implications for theories of state discovery in reinforcement learning.

  17. A fault diagnosis system for PV power station based on global partitioned gradually approximation method

    Science.gov (United States)

    Wang, S.; Zhang, X. N.; Gao, D. D.; Liu, H. X.; Ye, J.; Li, L. R.

    2016-08-01

    As the solar photovoltaic (PV) power is applied extensively, more attentions are paid to the maintenance and fault diagnosis of PV power plants. Based on analysis of the structure of PV power station, the global partitioned gradually approximation method is proposed as a fault diagnosis algorithm to determine and locate the fault of PV panels. The PV array is divided into 16x16 blocks and numbered. On the basis of modularly processing of the PV array, the current values of each block are analyzed. The mean current value of each block is used for calculating the fault weigh factor. The fault threshold is defined to determine the fault, and the shade is considered to reduce the probability of misjudgments. A fault diagnosis system is designed and implemented with LabVIEW. And it has some functions including the data realtime display, online check, statistics, real-time prediction and fault diagnosis. Through the data from PV plants, the algorithm is verified. The results show that the fault diagnosis results are accurate, and the system works well. The validity and the possibility of the system are verified by the results as well. The developed system will be benefit for the maintenance and management of large scale PV array.

  18. Meat quality in pigs fed diets with gradual ractopamine supplementation and nutritional adjustments

    Directory of Open Access Journals (Sweden)

    M. Amin

    2017-12-01

    Full Text Available This study evaluated the effects that gradual ractopamine supplementation in diets with nutritional adjustments on pig meat. Were used 80 finishing crossbred barrows in a randomized block design with a 2×5 factorial arrangement (two diets: with and without nutritional adjustment; five levels of ractopamine supplementation: 5-5, 10-10, 20-20, 5-10 and 10-20 ppm in the 14 initial and 14 final study days, four replicates with two animals by experimental unit. Higher shear force values (P<0.05 were obtained using the 5-5 and 10-20 ppm ractopamine supplementation plans in the diets without nutritional adjustment. With nutritionally adjusted diets, the 5-10 ppm of ractopamine supplementation plan yielded higher shear force values (P<0.05. Water retention capacity was higher (P<0.05 for animals fed adjusted diets and 5-5 and 10-20 ppm of actopamine plans. In the 10-20 ppm of ractopamine supplementation plan, meat pH was higher (P<0.05 for diets without nutritional adjustment, whereas in the 20-20 ppm of supplementation plan, pH was higher for adjusted diets.

  19. Quantifying short run cost-effectiveness during a gradual implementation process.

    Science.gov (United States)

    van de Wetering, Gijs; Woertman, Willem H; Verbeek, Andre L; Broeders, Mireille J; Adang, Eddy M M

    2013-12-01

    This paper examines the short run inefficiencies that arise during gradual implementation of a new cost-effective technology in healthcare. These inefficiencies arise when health gains associated with the new technology cannot be obtained immediately because the new technology does not yet supply all patients, and when there is overcapacity for the old technology in the short run because the supply of care is divided among two mutually exclusive technologies. Such efficiency losses are not taken into account in standard textbook cost-effectiveness analysis in which a steady state is presented where costs and effects are assumed to be unchanging over time. A model is constructed to quantify such short run inefficiencies as well as to inform the decision maker about the optimal implementation pattern for the new technology. The model operates by integrating the incremental net benefit equations for both the period of co-existence of mutually exclusive technologies and the period after complete substitution of the old technology. It takes into account the rate of implementation of the new technology, depreciation of capital of the old technology as well as the demand curves for both technologies. The model is applied to the real world case of converting from screen film to digital mammography in the Netherlands.

  20. Acoustic Source Analysis of Magnetoacoustic Tomography With Magnetic Induction for Conductivity Gradual-Varying Tissues.

    Science.gov (United States)

    Wang, Jiawei; Zhou, Yuqi; Sun, Xiaodong; Ma, Qingyu; Zhang, Dong

    2016-04-01

    As a multiphysics imaging approach, magnetoacoustic tomography with magnetic induction (MAT-MI) works on the physical mechanism of magnetic excitation, acoustic vibration, and transmission. Based on the theoretical analysis of the source vibration, numerical studies are conducted to simulate the pathological changes of tissues for a single-layer cylindrical conductivity gradual-varying model and estimate the strengths of sources inside the model. The results suggest that the inner source is generated by the product of the conductivity and the curl of the induced electric intensity inside conductivity homogeneous medium, while the boundary source is produced by the cross product of the gradient of conductivity and the induced electric intensity at conductivity boundary. For a biological tissue with low conductivity, the strength of boundary source is much higher than that of the inner source only when the size of conductivity transition zone is small. In this case, the tissue can be treated as a conductivity abrupt-varying model, ignoring the influence of inner source. Otherwise, the contributions of inner and boundary sources should be evaluated together quantitatively. This study provide basis for further study of precise image reconstruction of MAT-MI for pathological tissues.

  1. Sobre a classificação gradual das preposições

    Directory of Open Access Journals (Sweden)

    Lou-Ann Kepla

    2012-11-01

    Full Text Available O presente artigo está ancorado na Neurolinguística de orientação enunciativo-discursiva. A demanda por uma proposta de classificação gradual (em oposição à tradicional classificação categorial das preposições surgiu quando nos propusemos a tarefa de descrever o funcionamento das preposições na fala de sujeitos que apresentam uma linguagem heterogênea. Nestes casos, as classificações correntes das preposições não se mostraram satisfatórias. Os motivos pelos quais preferimos uma classificação que dispõe as preposições numa escala de acordo com os seus graus de gramaticalização serão dispostos depois de feita uma revisão da literatura sobre as classificações das preposições. As classificações propostas por diferentes gramáticos são analisadas juntamente com aquelas adotadas por linguistas preocupados em descrever a linguagem agramática de sujeitos com afasia de produção.

  2. Free surface profiles in river flows: Can standard energy-based gradually-varied flow computations be pursued?

    Science.gov (United States)

    Cantero, Francisco; Castro-Orgaz, Oscar; Garcia-Marín, Amanda; Ayuso, José Luis; Dey, Subhasish

    2015-10-01

    Is the energy equation for gradually-varied flow the best approximation for the free surface profile computations in river flows? Determination of flood inundation in rivers and natural waterways is based on the hydraulic computation of flow profiles. This is usually done using energy-based gradually-varied flow models, like HEC-RAS, that adopts a vertical division method for discharge prediction in compound channel sections. However, this discharge prediction method is not so accurate in the context of advancements over the last three decades. This paper firstly presents a study of the impact of discharge prediction on the gradually-varied flow computations by comparing thirteen different methods for compound channels, where both energy and momentum equations are applied. The discharge, velocity distribution coefficients, specific energy, momentum and flow profiles are determined. After the study of gradually-varied flow predictions, a new theory is developed to produce higher-order energy and momentum equations for rapidly-varied flow in compound channels. These generalized equations enable to describe the flow profiles with more generality than the gradually-varied flow computations. As an outcome, results of gradually-varied flow provide realistic conclusions for computations of flow in compound channels, showing that momentum-based models are in general more accurate; whereas the new theory developed for rapidly-varied flow opens a new research direction, so far not investigated in flows through compound channels.

  3. Reaching Reluctant Students: Insights from Torey Hayden.

    Science.gov (United States)

    Marlowe, Mike

    1999-01-01

    Illustrates principles of reaching students who fight or avoid adults by using examples drawn from the writings of Torey Hayden. Presents ten concepts that can serve as guidelines for building relationships with resistant children, and gives excerpts from Hayden's works to illustrate each concept. Demonstrates how books provide teachers with…

  4. ATLAS Barrel Toroid magnet reached nominal field

    CERN Multimedia

    2006-01-01

     On 9 November the barrel toroid magnet reached its nominal field of 4 teslas, with an electrical current of 21 000 amperes (21 kA) passing through the eight superconducting coils as shown on this graph

  5. A gradual change between methanogenesis and sulfidogenesis during a long-term UASB treatment of sulfate-rich chemical wastewater.

    Science.gov (United States)

    Wu, Jiang; Niu, Qigui; Li, Lu; Hu, Yong; Mribet, Chaimaa; Hojo, Toshimasa; Li, Yu-You

    2018-04-25

    The competition between methane-producing archaea and sulfate-reducing bacteria is an important topic in anaerobic wastewater treatment. In this study, an Up-flow Anaerobic Sludge Blanket Reactor (UASB) was operated for 330 days to evaluate the treatment performance of sulfate-rich wastewater. The effects of competition change between methane production and sulfate reduction on the organic removal efficiency, methane production, and electrons allocation were investigated. Synthetic wastewater was composed of ethanol and acetate with a chemical oxygen demand (COD)/SO 4 2- of 1.0. As a result, the COD removal efficiency achieved in long-term treatment was higher than 90%. During the initial stage, methane production was the dominant reaction. Sulfate-reducing bacteria (SRB) could only partially oxidize ethanol to acetate, and methane-producing archaea (MPA) utilized acetate for methane production. Methane production declined gradually over the long-term operation, whereas the sulfate-reducing efficiency increased. However, UASB performed well throughout the experiment because there was no significant inhibition. After the complete reduction of the sulfate, MPA converted the remaining COD into methane. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Evaluation of the force generated by gradual deflection of orthodontic wires in conventional metallic, esthetic, and self-ligating brackets

    Directory of Open Access Journals (Sweden)

    Manoela Fávaro Francisconi

    Full Text Available ABSTRACT Objective: The purpose of this study was to evaluate the deflection forces of Nitinol orthodontic wires placed in different types of brackets: metallic, reinforced polycarbonate with metallic slots, sapphire, passive and active self-ligating, by assessing strength values variation according to gradual increase in wire diameter and deflection and comparing different combinations in the different deflections. Material and Methods: Specimens were set in a clinical simulation model and evaluated in a Universal Testing Machine (INSTRON 3342, using the ISO 15841 protocol. Data were subjected to One-way ANOVA, followed by Tukey tests (p<0.05. Results: Self-ligating brackets presented the most similar behavior to each other. For conventional brackets there was no consistent behavior for any of the deflections studied. Conclusions: Self-ligating brackets presented the most consistent and predictable results while conventional brackets, as esthetic brackets, showed very different patterns of forces. Self-ligating brackets showed higher strength in all deflections when compared with the others, in 0.020-inch wires.

  7. Gradual development of the interferon-γ response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination

    International Nuclear Information System (INIS)

    Meier, William A.; Galeota, Judy; Osorio, Fernando A.; Husmann, Robert J.; Schnitzlein, William M.; Zuckermann, Federico A.

    2003-01-01

    Infection of swine with virulent porcine reproductive and respiratory syndrome (PRRS) virus induced a rapid, robust antibody response that comprised predominantly nonneutralizing antibodies and waned after approximately 3 months. In contrast, the initial onset of virus-specific interferon (IFN)-γ-secreting cells (SC) in the pig lymphocyte population remained at a fairly low level during this period and then increased gradually in frequency, plateauing at 6 months postinfection. A similar polarization of the host humoral and cellular immune responses was also observed in pigs immunized with a PRRS-modified live virus (MLV) vaccine. Even coadministration of an adjuvant that enhanced the immune response to a pseudorabies (PR) MLV vaccine failed to alter the induction of PRRS virus-specific IFN-γ SC (comprising predominately CD4/CD8α double positive memory T cells with a minority being typical CD4 - /CD8αβ + T cells) and the generation of neutralizing antibodies. Moreover, unlike inactivated PR virus, nonviable PRRS virus did not elicit virus-neutralizing antibody production. Presumably, an intrinsic property of this pathogen delays the development of the host IFN-γ response and preferentially stimulates the synthesis of antibodies incapable of neutralization

  8. Repeated rat-forced swim test: reducing the number of animals to evaluate gradual effects of antidepressants.

    Science.gov (United States)

    Mezadri, T J; Batista, G M; Portes, A C; Marino-Neto, J; Lino-de-Oliveira, C

    2011-02-15

    The forced swim test (FST) is a pre-clinical test to short and long term treatment with antidepressant drugs (ADT), which requires between-subject designs. Herein a modified protocol of the FST using within-subject design (repeated rat-FST) was evaluated. Male Wistar rats were submitted to 15 min of swimming (Day 1: pretest) followed by three subsequent 5 min-swimming tests one week apart (Day 2: test, Day 7: retest 1, Day 14: retest 2). To determine the temporal and factorial characteristics of the variables scored in the repeated rat-FST, the protocol was carried out in untreated animals (E1). To validate the method, daily injections of Fluoxetine (FLX, 2.5mg/kg, i.p.) or saline were given over a 2-week period (E2). Tests and retests have been videotaped for further register of the latency, frequency and duration of behaviors. Over retesting the latency to immobility decreased whereas duration of immobility tended to increase. Factorial analysis revealed that the test, the retest 1 as well as the retest 2 have variables suitable to detection of antidepressant-like effects of ADT. Compared to saline, FLX chronically administrated reduced duration of immobility whereas increased duration of swimming in retest 2. The data suggest that repeated rat-FST detected the gradual increase in the efficacy of low doses of FLX over time. Therefore, repeated rat-FST seemed suitable to detect short and long term effects of selective serotonin reuptake inhibitors, or other ADT, thus reducing the number of animals used in the screenings of this type of compounds. © 2010 Elsevier B.V. All rights reserved.

  9. Rapid and gradual modes of aerosol trace metal dissolution in seawater

    Directory of Open Access Journals (Sweden)

    Katherine Rose Marie Mackey

    2015-01-01

    Full Text Available Atmospheric deposition is a major source of trace metals in marine surface waters and supplies vital micronutrients to phytoplankton, yet measured aerosol trace metal solubility values are operationally defined and there are relatively few multi-element studies on aerosol-metal solubility in seawater. Here we measure the solubility of aluminum (Al, cadmium (Cd, cobalt (Co, copper (Cu, iron (Fe, manganese (Mn, nickel (Ni, lead (Pb, and zinc (Zn from natural aerosol samples in seawater over a 7 day period to (1 evaluate the role of extraction time in trace metal dissolution behavior and (2 explore how the individual dissolution patterns could influence biota. Dissolution behavior occurs over a continuum ranging from rapid dissolution, in which the majority of soluble metal dissolved immediately upon seawater exposure (Cd and Co in our samples, to gradual dissolution, where metals dissolved slowly over time (Zn, Mn, Cu, and Al in our samples. Additionally, dissolution affected by interactions with particles was observed in which a decline in soluble metal concentration over time occurred (Fe and Pb in our samples. Natural variability in aerosol chemistry between samples can cause metals to display different dissolution kinetics in different samples, and this was particularly evident for Ni, for which samples showed a broad range of dissolution rates. The elemental molar ratio of metals in the bulk aerosols was 23,189Fe: 22,651Al: 445Mn: 348Zn: 71Cu: 48Ni: 23Pb: 9Co: 1Cd, whereas the seawater soluble molar ratio after 7 days of leaching was 11Fe: 620Al: 205Mn: 240Zn: 20Cu: 14Ni: 9Pb: 2Co: 1Cd. The different kinetics and ratios of aerosol metal dissolution have implications for phytoplankton nutrition, and highlight the need for unified extraction protocols that simulate aerosol metal dissolution in the surface ocean.

  10. Osborne Reynolds pipe flow: Direct simulation from laminar through gradual transition to fully developed turbulence.

    Science.gov (United States)

    Wu, Xiaohua; Moin, Parviz; Adrian, Ronald J; Baltzer, Jon R

    2015-06-30

    The precise dynamics of breakdown in pipe transition is a century-old unresolved problem in fluid mechanics. We demonstrate that the abruptness and mysteriousness attributed to the Osborne Reynolds pipe transition can be partially resolved with a spatially developing direct simulation that carries weakly but finitely perturbed laminar inflow through gradual rather than abrupt transition arriving at the fully developed turbulent state. Our results with this approach show during transition the energy norms of such inlet perturbations grow exponentially rather than algebraically with axial distance. When inlet disturbance is located in the core region, helical vortex filaments evolve into large-scale reverse hairpin vortices. The interaction of these reverse hairpins among themselves or with the near-wall flow when they descend to the surface from the core produces small-scale hairpin packets, which leads to breakdown. When inlet disturbance is near the wall, certain quasi-spanwise structure is stretched into a Lambda vortex, and develops into a large-scale hairpin vortex. Small-scale hairpin packets emerge near the tip region of the large-scale hairpin vortex, and subsequently grow into a turbulent spot, which is itself a local concentration of small-scale hairpin vortices. This vortex dynamics is broadly analogous to that in the boundary layer bypass transition and in the secondary instability and breakdown stage of natural transition, suggesting the possibility of a partial unification. Under parabolic base flow the friction factor overshoots Moody's correlation. Plug base flow requires stronger inlet disturbance for transition. Accuracy of the results is demonstrated by comparing with analytical solutions before breakdown, and with fully developed turbulence measurements after the completion of transition.

  11. The Danish Peregrine Falcon population is increasing

    DEFF Research Database (Denmark)

    Andreasen, Niels Peter; Falk, Knud; Møller, Søren

    peregrine population has gradually increased – most rapidly since 2012 – to 19 known territorial pairs in 2016; some of them breeding on man-made structures (nest boxes at bridges and power plants). In this poster, we present detailed information on the reestablishment of the peregrine falcon in Denmark...... observed breeding in Demark: 3 from Sweden, 4 from Germany and 1 from Poland. Similarly, peregrines banded in Danish eyries have been observed as territorial or breeding in Sweden (2 cases) or at other locations in Denmark (5 cases). The reproduction measured as number of ‘young per successful pair......’ (reaching ringing age) and ‘young per occupied territory’ (“productivity”) is on average 2.2 and 1.3, respectively, for the entire period 2001-2016. The productivity of Danish peregrines is thus well above the critical limit (1.0 according to USFWS), where concerns may be raised. Not much is known about...

  12. Amplified Erosion above Waterfalls and Oversteepened Bedrock Reaches

    Science.gov (United States)

    Haviv, I.; Enzel, Y.; Whipple, K. X.; Zilberman, E.; Stone, J.; Matmon, A.; Fifield, K. L.

    2005-12-01

    Although waterfalls are abundant along steep bedrock channels, none of the conventional erosion laws can predict incision at the lip of a waterfall where flow is non-uniform and bed slope can be vertical. Considering the expected increase in flow velocity and shear stress at the lip of a vertical waterfall we determine erosion amplification at a waterfall lip as: Elip/Enormal= (1+0.4/Fr2)3n, where Fr is the Froude number and n ranges between 0.5-1.7. This amplification expression suggests that erosion at the lip could be as much as 2-5 times higher than normally expected in a setting with identical hydraulic geometry. It also demonstrates that a freefall is expected to amplify upstream incision rates even when the flow approaching the waterfall is highly supercritical. Utilizing this erosion amplification expression in numerical simulations in conjunction with a standard detachment-limited incision model we demonstrate its impact on reach-scale morphology above waterfalls. These simulations indicate that amplified erosion at the lip of a waterfall can trigger the formation of an oversteepened reach whose length is longer than the flow acceleration zone, provided incision velocity (Vi) at the edge of the flow acceleration zone is higher than the retreat velocity of the waterfall face. Such an oversteepened reach is expected to be more pronounced when Vi increases with increasing slope. The simulations also suggest that oversteepening can eventually lead to quasi steady-state gradients upstream from a waterfall provided Vi decreases with increasing slope. Flow acceleration above waterfalls can thus account, at least partially, for oversteepened bedrock reaches that are prevalent above waterfalls. Such reaches have been reported for the escarpments of southeast Australia, western Dead Sea, and at Niagara Falls. Using the cosmogenic isotope 36Cl we demonstrate that Vi upstream of a waterfall at the Dead Sea western escarpment is high enough for freefall

  13. A Preliminary Evaluation of Reach: Training Early Childhood Teachers to Support Children's Social and Emotional Development

    Science.gov (United States)

    Conners-Burrow, Nicola A.; Patrick, Terese; Kyzer, Angela; McKelvey, Lorraine

    2017-01-01

    This paper describes the development, implementation and preliminary evaluation of the Reaching Educators and Children (REACH) program, a training and coaching intervention designed to increase the capacity of early childhood teachers to support children's social and emotional development. We evaluated REACH with 139 teachers of toddler and…

  14. Inactivation of Parietal Reach Region Affects Reaching But Not Saccade Choices in Internally Guided Decisions.

    Science.gov (United States)

    Christopoulos, Vassilios N; Bonaiuto, James; Kagan, Igor; Andersen, Richard A

    2015-08-19

    The posterior parietal cortex (PPC) has traditionally been considered important for awareness, spatial perception, and attention. However, recent findings provide evidence that the PPC also encodes information important for making decisions. These findings have initiated a running argument of whether the PPC is critically involved in decision making. To examine this issue, we reversibly inactivated the parietal reach region (PRR), the area of the PPC that is specialized for reaching movements, while two monkeys performed a memory-guided reaching or saccade task. The task included choices between two equally rewarded targets presented simultaneously in opposite visual fields. Free-choice trials were interleaved with instructed trials, in which a single cue presented in the peripheral visual field defined the reach and saccade target unequivocally. We found that PRR inactivation led to a strong reduction of contralesional choices, but only for reaches. On the other hand, saccade choices were not affected by PRR inactivation. Importantly, reaching and saccade movements to single instructed targets remained largely intact. These results cannot be explained as an effector-nonspecific deficit in spatial attention or awareness, since the temporary "lesion" had an impact only on reach choices. Hence, the PPR is a part of a network for reach decisions and not just reach planning. There has been an ongoing debate on whether the posterior parietal cortex (PPC) represents only spatial awareness, perception, and attention or whether it is also involved in decision making for actions. In this study we explore whether the parietal reach region (PRR), the region of the PPC that is specialized for reaches, is involved in the decision process. We inactivated the PRR while two monkeys performed reach and saccade choices between two targets presented simultaneously in both hemifields. We found that inactivation affected only the reach choices, while leaving saccade choices intact

  15. Does workplace health promotion reach shift workers?

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Garde, Anne Helene; Clausen, Thomas

    2015-01-01

    OBJECTIVES: One reason for health disparities between shift and day workers may be that workplace health promotion does not reach shift workers to the same extent as it reaches day workers. This study aimed to investigate the association between shift work and the availability of and participation...... in workplace health promotion. METHODS: We used cross-sectional questionnaire data from a large representative sample of all employed people in Denmark. We obtained information on the availability of and participation in six types of workplace health promotion. We also obtained information on working hours, ie......). RESULTS: In the general working population, fixed evening and fixed night workers, and employees working variable shifts including night work reported a higher availability of health promotion, while employees working variable shifts without night work reported a lower availability of health promotion...

  16. Olefins and chemical regulation in Europe: REACH.

    Science.gov (United States)

    Penman, Mike; Banton, Marcy; Erler, Steffen; Moore, Nigel; Semmler, Klaus

    2015-11-05

    REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) is the European Union's chemical regulation for the management of risk to human health and the environment (European Chemicals Agency, 2006). This regulation entered into force in June 2007 and required manufacturers and importers to register substances produced in annual quantities of 1000 tonnes or more by December 2010, with further deadlines for lower tonnages in 2013 and 2018. Depending on the type of registration, required information included the substance's identification, the hazards of the substance, the potential exposure arising from the manufacture or import, the identified uses of the substance, and the operational conditions and risk management measures applied or recommended to downstream users. Among the content developed to support this information were Derived No-Effect Levels or Derived Minimal Effect Levels (DNELs/DMELs) for human health hazard assessment, Predicted No Effect Concentrations (PNECs) for environmental hazard assessment, and exposure scenarios for exposure and risk assessment. Once registered, substances may undergo evaluation by the European Chemicals Agency (ECHA) or Member State authorities and be subject to requests for additional information or testing as well as additional risk reduction measures. To manage the REACH registration and related activities for the European olefins and aromatics industry, the Lower Olefins and Aromatics REACH Consortium was formed in 2008 with administrative and technical support provided by Penman Consulting. A total of 135 substances are managed by this group including 26 individual chemical registrations (e.g. benzene, 1,3-butadiene) and 13 categories consisting of 5-26 substances. This presentation will describe the content of selected registrations prepared for 2010 in addition to the significant post-2010 activities. Beyond REACH, content of the registrations may also be relevant to other European activities, for

  17. Performance reach in the LHC for 2012

    International Nuclear Information System (INIS)

    Arduini, G.

    2012-01-01

    Based on the 2011 experience and Machine Development study results, the performance reach of the LHC with 25 and 50 ns beams will be addressed for operation at 3.5 and 4 TeV. The possible scrubbing scenarios and potential intensity limitations resulting from vacuum, heating will be taken into account wherever possible. The paper mainly covers the performance of the two high luminosity regions in IR1 and IR5. (author)

  18. Morphological Adjustment in the Wandering Reach of the Lower Yellow River in Response to the Changes in Water and Sediment Supply over the Recent Decades

    Science.gov (United States)

    Xie, Z.; Huang, H. Q.; Yu, G.

    2017-12-01

    The flow-sediment regime entering into the LYR has changed significantly since the 1970s due to the increasing intensity of human activities. To understand how the wandering reach of the LYR adjusts its channel morphology in response to the change in the flow-sediment regime, this study extracts a series of channel cross-profiles from remote sensing images taken since 1979. It is shown clearly that at one-year timescale, the main flow has shifted significantly, while the sinuosity of the pathways of main flow increased initially, then decreased significantly from 2006 and experienced little variation since 2010. Meanwhile, the width of the wandering belt has been increasing at a very slow stepwise fashion since 2002, and the area of central bars varied with fluctuations before 2009 and yet took a rapidly increasing trend since then. In contrast, the braiding intensity of the wandering reach has shown little change, while the river channel bed and the width/depth ratio of the main channel have taken significant adjustments, with the channel bed being scoured down to a considerable degree and the width/depth ratio varying in a gradually declining trend. These adjustments in the morphology of the Lower Yellow River implicate that the perched situation of the Lower Yellow River can be reversed.

  19. A gradual update method for simulating the steady-state solution of stiff differential equations in metabolic circuits.

    Science.gov (United States)

    Shiraishi, Emi; Maeda, Kazuhiro; Kurata, Hiroyuki

    2009-02-01

    Numerical simulation of differential equation systems plays a major role in the understanding of how metabolic network models generate particular cellular functions. On the other hand, the classical and technical problems for stiff differential equations still remain to be solved, while many elegant algorithms have been presented. To relax the stiffness problem, we propose new practical methods: the gradual update of differential-algebraic equations based on gradual application of the steady-state approximation to stiff differential equations, and the gradual update of the initial values in differential-algebraic equations. These empirical methods show a high efficiency for simulating the steady-state solutions for the stiff differential equations that existing solvers alone cannot solve. They are effective in extending the applicability of dynamic simulation to biochemical network models.

  20. Riparian Vegetation Mapping Along the Hanford Reach

    International Nuclear Information System (INIS)

    FOGWELL, T.W.

    2003-01-01

    During the biological survey and inventory of the Hanford Site conducted in the mid-1990s (1995 and 1996), preliminary surveys of the riparian vegetation were conducted along the Hanford Reach. These preliminary data were reported to The Nature Conservancy (TNC), but were not included in any TNC reports to DOE or stakeholders. During the latter part of FY2001, PNNL contracted with SEE Botanical, the parties that performed the original surveys in the mid 1990s, to complete the data summaries and mapping associated with the earlier survey data. Those data sets were delivered to PNNL and the riparian mapping by vegetation type for the Hanford Reach is being digitized during the first quarter of FY2002. These mapping efforts provide the information necessary to create subsequent spatial data layers to describe the riparian zone according to plant functional types (trees, shrubs, grasses, sedges, forbs). Quantification of the riparian zone by vegetation types is important to a number of DOE'S priority issues including modeling contaminant transport and uptake in the near-riverine environment and the determination of ecological risk. This work included the identification of vegetative zones along the Reach by changes in dominant plant species covering the shoreline from just to the north of the 300 Area to China Bar near Vernita. Dominant and indicator species included Agropyron dasytachyudA. smithii, Apocynum cannabinum, Aristida longiseta, Artemisia campestris ssp. borealis var scouleriana, Artemisa dracunculus, Artemisia lindleyana, Artemisia tridentata, Bromus tectorum, Chrysothamnus nauseosus, Coreopsis atkinsoniana. Eleocharis palustris, Elymus cinereus, Equisetum hyemale, Eriogonum compositum, Juniperus trichocarpa, Phalaris arundinacea, Poa compressa. Salk exigua, Scirpus acutus, Solidago occidentalis, Sporobolus asper,and Sporobolus cryptandrus. This letter report documents the data received, the processing by PNNL staff, and additional data gathered in FY2002

  1. Long-reach manipulators for decommissioning

    International Nuclear Information System (INIS)

    Webster, D.A.; Challinor, S.F.

    1993-01-01

    A survey of redundant facilities at Sellafield has identified that in many cases the conventional means of deploying remote handling equipment are not appropriate and that novel means must be employed. However, decommissioning is not a value adding activity and so expensive one off designs must be avoided. The paper will describe BNFL's approach to the synthesis from proprietary parts of a manipulator which can lift 3 te at a horizontal reach of over 5 metres and yet can still perform the dextrous manipulation necessary to remove small items. It will also cover the development of the manipulator control systems and the adaption of commercial handtools to be manipulator friendly. (author)

  2. Luminosity performance reach after LS1

    International Nuclear Information System (INIS)

    Herr, W.

    2012-01-01

    Based on past experience (2010/2011), in particular expected limitations from beam-beam effects, and taking into account the expected beam quality from the LHC injectors, the peak and integrated luminosity at top energy is discussed for different scenarios (e.g. bunch spacing, beta*). In particular it will be shown which are the key parameters to reach the nominal luminosity and it is also shown that peak luminosities two times larger than nominal (or higher) are possible. Possible test in 2012 are discussed

  3. City Reach Code Technical Support Document

    Energy Technology Data Exchange (ETDEWEB)

    Athalye, Rahul A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chen, Yan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhang, Jian [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Liu, Bing [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Frankel, Mark [New Buildings Inst., Portland, OR (United States); Lyles, Mark [New Buildings Inst., Portland, OR (United States)

    2017-10-31

    This report describes and analyzes a set of energy efficiency measures that will save 20% energy over ASHRAE Standard 90.1-2013. The measures will be used to formulate a Reach Code for cities aiming to go beyond national model energy codes. A coalition of U.S. cities together with other stakeholders wanted to facilitate the development of voluntary guidelines and standards that can be implemented in stages at the city level to improve building energy efficiency. The coalition's efforts are being supported by the U.S. Department of Energy via Pacific Northwest National Laboratory (PNNL) and in collaboration with the New Buildings Institute.

  4. The Relationship between Mechanical Properties and Gradual Deterioration of Microstructures of Rock Mass Subject to Freeze-thaw Cycles

    Directory of Open Access Journals (Sweden)

    Haibo Jiang

    2018-01-01

    Full Text Available Under freeze-thaw cycles, the relationship between rock microstructure deterioration and its macroscopic mechanical characteristics has drawn extensive attention from engineers. With the objective to incorporate freeze-thaw cycle experiment into headrace tunnel engineering, in the present study two groups of andesite rock samples in different states are tested under the conditions of the lowest freezing temperature of –40 ℃ and the thawing temperature of 20 ℃. Damage detection was performed by magnetic resonance imaging for the interior microstructure of rock samples subject to different freeze-thaw cycles, and the relationship between the sample mechanical properties and gradual deterioration of rock microstructures was discussed. The results demonstrate evident influence of freeze-thaw cycle on the damage and deterioration of internal pore structure in andesite, and the rock uniaxial compressive strength and elasticity modulus exhibit a decreasing trend with the increase of freeze-thaw cycles. After 40 cycles, the strength of naturally saturated rock samples decreases by 39.4% (equivalent to 69.4 MPa and the elasticity modulus drops by 47.46% (equivalent to 3.27 GPa. For rock samples saturated by vacuum, 40 freeze-thaw cycles lead to a decrease of 36.86% (equivalent to 58.2 MPa in rock strength and a drop of 44.85% (equivalent to 2.83 GPa in elasticity modulus. Therefore, the test results quantitatively elucidate the substantial influence of freeze-thaw cycle on the damage and deterioration of internal structure in andesite.

  5. Can donated media placements reach intended audiences?

    Science.gov (United States)

    Cooper, Crystale Purvis; Gelb, Cynthia A; Chu, Jennifer; Polonec, Lindsey

    2013-09-01

    Donated media placements for public service announcements (PSAs) can be difficult to secure, and may not always reach intended audiences. Strategies used by the Centers for Disease Control and Prevention's (CDC) Screen for Life: National Colorectal Cancer Action Campaign (SFL) to obtain donated media placements include producing a diverse mix of high-quality PSAs, co-branding with state and tribal health agencies, securing celebrity involvement, monitoring media trends to identify new distribution opportunities, and strategically timing the release of PSAs. To investigate open-ended recall of PSAs promoting colorectal cancer screening, CDC conducted 12 focus groups in three U.S. cities with men and women either nearing age 50 years, when screening is recommended to begin, or aged 50-75 years who were not in compliance with screening guidelines. In most focus groups, multiple participants recalled exposure to PSAs promoting colorectal cancer screening, and most of these individuals reported having seen SFL PSAs on television, in transit stations, or on the sides of public buses. Some participants reported exposure to SFL PSAs without prompting from the moderator, as they explained how they learned about the disease. Several participants reported learning key campaign messages from PSAs, including that colorectal cancer screening should begin at age 50 years and screening can find polyps so they can be removed before becoming cancerous. Donated media placements can reach and educate mass audiences, including millions of U.S. adults who have not been screened appropriately for colorectal cancer.

  6. Efficacy of REACH Forgiveness across cultures.

    Science.gov (United States)

    Lin, Yin; Worthington, Everett L; Griffin, Brandon J; Greer, Chelsea L; Opare-Henaku, Annabella; Lavelock, Caroline R; Hook, Joshua N; Ho, Man Yee; Muller, Holly

    2014-09-01

    This study investigates the efficacy of the 6-hour REACH Forgiveness intervention among culturally diverse undergraduates. Female undergraduates (N = 102) and foreign extraction (46.2%) and domestic (43.8%) students in the United States were randomly assigned to immediate treatment or waitlist conditions. Treatment efficacy and the effect of culture on treatment response were assessed using measures of emotional and decisional forgiveness across 3 time periods. Students in the treatment condition reported greater improvement in emotional forgiveness, but not decisional forgiveness, relative to those in the waitlist condition. Gains were maintained at a 1-week follow-up. Although culture did not moderate the effect of treatment, a main effect of culture on emotional forgiveness and marginally significant interaction effect of culture on decisional forgiveness were found. The REACH Forgiveness intervention was efficacious for college students from different cultural backgrounds when conducted in the United States. However, some evidence may warrant development of culturally adapted forgiveness interventions. © 2014 Wiley Periodicals, Inc.

  7. [Responses of functional diversity of aquatic insect community to land use change in middle reach of Qiantang River, East China].

    Science.gov (United States)

    Zhang, Lian-Bo; Liu, Dong-Xiao; Liu, Shuo-Ru; Zhang, Yong; Tong, Xiao-Li; Wang, Bei-Xin

    2013-10-01

    Based on the biological traits such as life history, resistance ability against environmental disturbance, and physiological characteristics of aquatic insects, and by using the fourth-corner statistical method, this paper studied the responses of the functional diversity of aquatic insect community to land use change in the middle reach of Qiantang River, Zhejiang Province of East China. For the test aquatic insect community, some of its biological traits were sensitive to land use change, and altered along human disturbance gradients as expected. With the increasing intensity of human disturbance, the maximal insect body length decreased gradually, the dominant respiration pattern evolved from gill respiration to tegument respiration, and the abundance of burrowers increased significantly. At the same time, the functional diversity measured as Rao's quadratic entropy was significantly higher in reference sites than in disturbed sites (P aquatic community were mainly induced by the land use change caused by human activities, which resulted in the decline of stream water quality and habitat quality and the variations of aquatic insect community composition and biological traits. The aquatic insect biological traits and functional diversity could be the potentially effective indicators in the stream health assessment in the future.

  8. Thermal evaluation by infrared measurement of implant site preparation between single and gradual drilling in artificial bone blocks of different densities.

    Science.gov (United States)

    Möhlhenrich, S C; Abouridouane, M; Heussen, N; Hölzle, F; Klocke, F; Modabber, A

    2016-11-01

    The aim of this study was to investigate the influence of bone density and drilling protocol on heat generation during implant bed preparation. Ten single and 10 gradual implant sites with diameters of 2.8, 3.5, and 4.2mm were prepared in four artificial bone blocks (density types I-IV; D1-D4). Drilling was done at constant speed (1500rpm) and with external irrigation (50ml/min); vertical speed was set at 2mm/s. An infrared camera was used for temperature measurements. Significantly higher temperatures for single drilling were found between 2.8-mm drills in D1 (P=0.0014) and D4 (P<0.0001) and between 3.5-mm drills in D3 (P=0.0087) and D4 (P<0.0001), as well as between 4.2-mm drills in D1 (P<0.0001) and D4 (P=0.0014). Low bone density led to a thermal decrease after single drilling and a thermal increase after gradual drilling. Burs with a large diameter always showed a higher temperature generation. In comparisons between 2.8- and 4.2-mm diameters for both single and gradual drills, significant differences (P<0.001) were noted for bone types II, III, and IV. Single drilling could generate more heat than traditional sequential drilling, and bone density, as well as drill diameter, influenced thermal increases. Particularly in lower-density bone, conventional sequential drilling seems to raise the temperature less. Copyright © 2016 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  9. Gradual aridification of the Sahara during the last 11,000 years revealed by plant wax δD analyses of Lake Yoa (Chad)

    Science.gov (United States)

    Rethemeyer, Janet; Kröpelin, Stefan; Karls, Jens; Thienemann, Matthias; Melles, Martin; Schefuß, Enno

    2014-05-01

    It is still an ongoing debate whether the transition of the last 'green Sahara' period to today's large desert during the Holocene, the African Humid Period (AHP), was a progressive or an abrupt change in hydrological conditions. Several climate records mainly from East Africa suggest a rapid decline of moisture availability at the end of the AHP including new data from a marine sequence off the Horn of Africa (Tierney & deMenocal, 2013). Other archives including sedimentological, geochemical and palynological data from the central North African Lakes Chad and Lake Yoa point to a gradual rather than an abrupt transition near 5,000 years ago (Amaral et al., 2013; Kröpelin et al., 2008). The discrepancy of the available paleo-hydrological reconstructions underline the importance of proxy parameters directly related to hydrological conditions for accurate assessment of continental rainfall changes. Here, we present the first molecular-isotopic data from Lake Yoa documenting the hydrologic evolution over the entire Holocene. Compound-specific carbon and hydrogen isotope analyses were performed on long-chain n-alkanes. Our data indicate relative high but variable contributions of plant-derived long-chain n-alkanes carrying a distinct leaf-wax signature, i.e., a high Carbon Preference Index (CPI). A trend towards higher CPI values since 7,300 years ago suggests declining soil degradation and vegetation cover under increasingly drier conditions. In parallel, the average-chain-length of the long-chain n-alkanes increases gradually towards the present implying higher relative contributions from grasses. Compound-specific carbon isotope data confirm this finding, indicating a mixed C3/C4 contribution in the early and mid-Holocene changing towards a C4-grass dominated vegetation in the late Holocene. Most importantly, compound-specific hydrogen isotope data reveal a continuous increase from 8,100 years ago towards the present, reflecting a gradual aridification. The large

  10. A comparative study on oxidative stress response in the hepatopancreas and midgut of the white shrimp Litopenaeus vannamei under gradual changes to low or high pH environment.

    Science.gov (United States)

    Han, Si-Yin; Wang, Meng-Qiang; Wang, Bao-Jie; Liu, Mei; Jiang, Ke-Yong; Wang, Lei

    2018-05-01

    White shrimp Litopenaeus vannamei were reared under conditions of gradual changes to a low pH (gradual-low pH, 6.65-8.20) or a high pH (gradual-high pH, 8.20-9.81) versus a normal pH environment (8.14-8.31) during a 28-day period. Survival of shrimp, and ROS production, antioxidant responses and oxidative damage in the hepatopancreas and midgut were investigated. Consequently, shrimp enhanced MnSOD, GPx, and Hsp70 transcripts as early defense mechanism in the hepatopancreas and midgut to scavenge excessive ROS during short-term (≤ 7 days) gradual-low and high pH stress. Meanwhile, the hepatopancreas was more sensitive to ROS than midgut because of earlier ROS production increase, antioxidant response and oxidative damage. Then, suppressed antioxidant response in the hepatopancreas and midgut of shrimp suggested a loss of antioxidant regulatory capacity caused by aggravated oxidative damage after long-term (≥ 14 days) gradual-high pH stress, leading to continuous death. However, enhanced GPx, GST, and Hsp70 transcripts in the hepatopancreas and midgut might be long-term(≥ 14 days) antioxidant adaptation mechanism of shrimp to gradual-low pH stress, which could prevent further ROS perturbation and weaken oxidative damage to achieve a new immune homeostasis, contributing to stable survival rate. Therefore, we have a few insights that it is necessary to protect hepatopancreas for controlling shrimp death under gradual-high pH stress. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. Riparian Vegetation Mapping Along the Hanford Reach

    Energy Technology Data Exchange (ETDEWEB)

    FOGWELL, T.W.

    2003-07-11

    During the biological survey and inventory of the Hanford Site conducted in the mid-1990s (1995 and 1996), preliminary surveys of the riparian vegetation were conducted along the Hanford Reach. These preliminary data were reported to The Nature Conservancy (TNC), but were not included in any TNC reports to DOE or stakeholders. During the latter part of FY2001, PNNL contracted with SEE Botanical, the parties that performed the original surveys in the mid 1990s, to complete the data summaries and mapping associated with the earlier survey data. Those data sets were delivered to PNNL and the riparian mapping by vegetation type for the Hanford Reach is being digitized during the first quarter of FY2002. These mapping efforts provide the information necessary to create subsequent spatial data layers to describe the riparian zone according to plant functional types (trees, shrubs, grasses, sedges, forbs). Quantification of the riparian zone by vegetation types is important to a number of DOE'S priority issues including modeling contaminant transport and uptake in the near-riverine environment and the determination of ecological risk. This work included the identification of vegetative zones along the Reach by changes in dominant plant species covering the shoreline from just to the north of the 300 Area to China Bar near Vernita. Dominant and indicator species included Agropyron dasytachyudA. smithii, Apocynum cannabinum, Aristida longiseta, Artemisia campestris ssp. borealis var scouleriana, Artemisa dracunculus, Artemisia lindleyana, Artemisia tridentata, Bromus tectorum, Chrysothamnus nauseosus, Coreopsis atkinsoniana. Eleocharis palustris, Elymus cinereus, Equisetum hyemale, Eriogonum compositum, Juniperus trichocarpa, Phalaris arundinacea, Poa compressa. Salk exigua, Scirpus acutus, Solidago occidentalis, Sporobolus asper,and Sporobolus cryptandrus. This letter report documents the data received, the processing by PNNL staff, and additional data gathered in FY

  12. Reach and get capability in a computing environment

    Science.gov (United States)

    Bouchard, Ann M [Albuquerque, NM; Osbourn, Gordon C [Albuquerque, NM

    2012-06-05

    A reach and get technique includes invoking a reach command from a reach location within a computing environment. A user can then navigate to an object within the computing environment and invoke a get command on the object. In response to invoking the get command, the computing environment is automatically navigated back to the reach location and the object copied into the reach location.

  13. Unified communication to reach vulnerable mothers.

    Science.gov (United States)

    Tezcan, B; Von Rege, I; Henkson, H; Oteng-Ntim, E

    2011-01-01

    The feasibility of using a mobile text to reach vulnerable patient groups was assessed in this study. A total of 121 pregnant or postnatal women were randomly asked to complete a questionnaire. The questionnaire was given to them in the antenatal clinic, postnatal ward, antenatal ward or in the day assessment unit at St Thomas' Hospital, London. The forms were collected and analysed using an Excel database. The results of this survey show that mobile technology is readily available for 97% of the obstetric population. In mothers from vulnerable groups and in mothers from deprived areas, 61% possessed 3rd generation mobile technology. The majority of mothers surveyed wanted their care supplemented by the use of their mobile phones.

  14. Gradual DropIn of Layers to Train Very Deep Neural Networks

    OpenAIRE

    Smith, Leslie N.; Hand, Emily M.; Doster, Timothy

    2015-01-01

    We introduce the concept of dynamically growing a neural network during training. In particular, an untrainable deep network starts as a trainable shallow network and newly added layers are slowly, organically added during training, thereby increasing the network's depth. This is accomplished by a new layer, which we call DropIn. The DropIn layer starts by passing the output from a previous layer (effectively skipping over the newly added layers), then increasingly including units from the ne...

  15. Evaluación de la resistencia al choque térmico de recubrimientos de estructura gradual obtenidos mediante proyección plasma

    Directory of Open Access Journals (Sweden)

    Guilemany, J. M.

    2001-12-01

    Full Text Available Power increasing demand in aeronautical engines promoted the development of thermal barrier coatings (TBCs obtained by Atmospheric Plasma Spray (APS. The spectacular growth in their applications leads to the demand of a very specific TBC. One of the specific roles that must achieve some TBCs is to withstand severe thermal shocks. Functionally Graded Coatings (FGC can improve their lives due to the lack of interfaces between two layers with very different thermal expansion coefficient (TEC (for example a metallic layer and a ceramic layer. Differences in TEC increase the internal stresses during the cooling of the parts. In this work thermal spray conditions have been improved in order to obtain Functionally Graded Coatings. Thermal Shock Resistance of these coatings has been compared with conventional' s one. Thermal Spray conditions have been used in order to spray two different powders with very different melting point. In that way it is possible to build up Functionally Graded Coatings with a unique spray gun. Thermal Shock Resistance of Coatings is improved due to the lack of interfaces between layers with different Thermal Expansion Coefficients unlike the conventional coatings where two layers of different materials are put together.

    La creciente demanda de mayores temperaturas de trabajo y potencia en el sector de la aviación promovió el desarrollo de las barreras térmicas (TBCs obtenidas por la técnica de proyección térmica plasma (APS. Éstas se componen de una capa de anclaje y una capa cerámica aislante. El espectacular aumento en el uso de las TBCs hace que se requieran recubrimientos cada vez más específicos en función de cada aplicación. Para mejorar la vida de los recubrimientos frente a los choques térmicos se han desarrollado los recubrimientos graduales. Éstos constan de una capa con variación gradual de los componentes, eliminando las intercaras entre partes con diferentes coeficientes de expansión t

  16. Parameter changes during gradual flooding of a PEM fuel cell through EIS studies; Cambio en parametros de una celda de combustible PEM durante inundacion gradual mediante estudios de EIS

    Energy Technology Data Exchange (ETDEWEB)

    Cano Castillo, Ulises; Cruz Manzo, Samuel; Arriaga Hurtado, Gerardo [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Ortiz, Alondra; Orozco, German [Centro de Investigacion y Desarrollo Tecnologico en Electroquimica S.C. (CIDETEQ) (Mexico)

    2008-07-01

    The gradual flooding of a single PEM fuel cell was produced and Electrochemical Impedance Spectroscopy (EIS) measurements were realized in order to follow changes of the fuel cell impedance parameters. These changes were followed by using two equivalent circuit models: one simple model of the Randles type accounting for cathode and anode interfaces and a more complex model based on distributed elements, more suitable for porous electrodes in order to include protonic resistance of the catalyst layers. [Spanish] La inundacion gradual de una monocelda de combustible tipo PEM fue estudiada empleando espectroscopia de impedancia electroquimica (EIS), con el proposito de seguir cambios en los parametros de impedancia de la celda. Estos cambios fueron estudiados utilizando dos circuitos equivalentes: un modelo simple de tipo Randles, el cual considerara las interfaces del catodo y del anodo, y un modelo mas complejo basado en elementos distribuidos, el cual fuera adecuado para electrodos porosos, a fin de incluir la resistencia protonica de las capas catalizadoras.

  17. Gradual retirement schemes and older workers : social inclusion and employability in the Netherlands

    NARCIS (Netherlands)

    Gellert, Franz Jozef; Velthuijsen, Hugo

    The number of employees above 50 is increasing in organizations because of demographic changes. People above 50 feel less involved in work and societal activities as they should be and as they are expected to be. Older workers‟ employment is accompanied by stereotyping that workers are less

  18. Too little sleep gradually desensitizes the serotonin 1A receptor system

    NARCIS (Netherlands)

    Roman, Viktor; Walstra, Irene; Luiten, PGM; Meerlo, P

    2005-01-01

    Study Objectives: In our 24-hour society, frequently disrupted and restricted sleep is a rapidly increasing problem that may contribute to the development of diseases such as depression. One of the proposed neurobiological mechanisms underlying depression is a disturbance in the brain's serotonergic

  19. Toxicological comments to the discussion about REACH.

    Science.gov (United States)

    Greim, Helmut; Arand, Michael; Autrup, Herman; Bolt, Hermann M; Bridges, James; Dybing, Erik; Glomot, Rémi; Foa, Vito; Schulte-Hermann, Rolf

    2006-03-01

    It is the ultimate goal of the intended REACH process (Registration, Evaluation and Authorization of Chemicals) of the European Union to identify substances of hazardous properties and to evaluate the risks of human and environmental exposure. During the last few months there has been a controversial discussion as to what extent in vitro studies and consideration of structure activity relationship provide sufficient information to waive repeated exposure studies. Industry as well as certain regulatory agencies or NGOs support this approach and propose that repeated dose studies may only be required beyond 100 t/a. From a toxicological point of view it has to be stressed that this discussion primarily considers the cost reduction and protection of animals, whereas protection of human health and the environment are secondary. In vitro studies only allow identification of specific hazardous properties which can be detected by the specific test system. Moreover, appropriate information on the dose response of adverse effects, identification of thresholds and NOELs that are essential for risk characterization cannot be obtained from these studies. Consequently, identification of all relevant hazardous properties and endpoints of adverse effects can only be determined in the intact animal by repeated dose studies such as 28-day or 90-day studies. In the absence of such information the hazard identification is incomplete and there is no basis for appropriate risk assessment of human exposure. Thus, any waiving of repeated dose studies in animals bears the probability of unforeseen effects in case of acute or continuous human exposure. From this the undersigning European Toxicologists conclude: 1. The intention of REACH is to identify hazardous properties in order that a reliable risk assessment can be made and measures taken to deal with chemicals posing a significant risk. 2. The recent debate has centered on ways in which the well established in vivo methods for risk

  20. ESO telbib: Linking In and Reaching Out

    Science.gov (United States)

    Grothkopf, U.; Meakins, S.

    2015-04-01

    Measuring an observatory's research output is an integral part of its science operations. Like many other observatories, ESO tracks scholarly papers that use observational data from ESO facilities and uses state-of-the-art tools to create, maintain, and further develop the Telescope Bibliography database (telbib). While telbib started out as a stand-alone tool mostly used to compile lists of papers, it has by now developed into a multi-faceted, interlinked system. The core of the telbib database is links between scientific papers and observational data generated by the La Silla Paranal Observatory residing in the ESO archive. This functionality has also been deployed for ALMA data. In addition, telbib reaches out to several other systems, including ESO press releases, the NASA ADS Abstract Service, databases at the CDS Strasbourg, and impact scores at Altmetric.com. We illustrate these features to show how the interconnected telbib system enhances the content of the database as well as the user experience.

  1. Using New Media to Reach Broad Audiences

    Science.gov (United States)

    Gay, P. L.

    2008-06-01

    The International Year of Astronomy New Media Working Group (IYA NMWG) has a singular mission: To flood the Internet with ways to learn about astronomy, interact with astronomers and astronomy content, and socially network with astronomy. Within each of these areas, we seek to build lasting programs and partnerships that will continue beyond 2009. Our weapon of choice is New Media. It is often easiest to define New Media by what it is not. Television, radio, print and their online redistribution of content are not New Media. Many forms of New Media start as user provided content and content infrastructures that answer that individual's creative whim in a way that is adopted by a broader audience. Classic examples include Blogs and Podcasts. This media is typically distributed through content specific websites and RSS feeds, which allow syndication. RSS aggregators (iTunes has audio and video aggregation abilities) allow subscribers to have content delivered to their computers automatically when they connect to the Internet. RSS technology is also being used in such creative ways as allowing automatically updating Google-maps that show the location of someone with an intelligent GPS system, and in sharing 100 word microblogs from anyone (Twitters) through a single feed. In this poster, we outline how the IYA NMWG plans to use New Media to reach target primary audiences of astronomy enthusiasts, image lovers, and amateur astronomers, as well as secondary audiences, including: science fiction fans, online gamers, and skeptics.

  2. Media perspective - new opportunities for reaching audiences

    Science.gov (United States)

    Haswell, Katy

    2007-08-01

    The world of media is experiencing a period of extreme and rapid change with the rise of internet television and the download generation. Many young people no longer watch standard TV. Instead, they go on-line, talking to friends and downloading pictures, videos, music clips to put on their own websites and watch/ listen to on their laptops and mobile phones. Gone are the days when TV controllers determined what you watched and when you watched it. Now the buzzword is IPTV, Internet Protocol Television, with companies such as JOOST offering hundreds of channels on a wide range of subjects, all of which you can choose to watch when and where you wish, on your high-def widescreen with stereo surround sound at home or on your mobile phone on the train. This media revolution is changing the way organisations get their message out. And it is encouraging companies such as advertising agencies to be creative about new ways of accessing audiences. The good news is that we have fresh opportunities to reach young people through internet-based media and material downloaded through tools such as games machines, as well as through the traditional media. And it is important for Europlanet to make the most of these new and exciting developments.

  3. Has Athletic Performance Reached its Peak?

    Science.gov (United States)

    Berthelot, Geoffroy; Sedeaud, Adrien; Marck, Adrien; Antero-Jacquemin, Juliana; Schipman, Julien; Saulière, Guillaume; Marc, Andy; Desgorces, François-Denis; Toussaint, Jean-François

    2015-09-01

    Limits to athletic performance have long been a topic of myth and debate. However, sport performance appears to have reached a state of stagnation in recent years, suggesting that the physical capabilities of humans and other athletic species, such as greyhounds and thoroughbreds, cannot progress indefinitely. Although the ultimate capabilities may be predictable, the exact path for the absolute maximal performance values remains difficult to assess and relies on technical innovations, sport regulation, and other parameters that depend on current societal and economic conditions. The aim of this literature review was to assess the possible plateau of top physical capabilities in various events and detail the historical backgrounds and sociocultural, anthropometrical, and physiological factors influencing the progress and regression of athletic performance. Time series of performances in Olympic disciplines, such as track and field and swimming events, from 1896 to 2012 reveal a major decrease in performance development. Such a saturation effect is simultaneous in greyhound, thoroughbred, and frog performances. The genetic condition, exhaustion of phenotypic pools, economic context, and the depletion of optimal morphological traits contribute to the observed limitation of physical capabilities. Present conditions prevailing, we approach absolute physical limits and endure a continued period of world record scarcity. Optional scenarios for further improvements will mostly depend on sport technology and modification competition rules.

  4. LEP Dismantling Reaches Half-Way Stage

    CERN Multimedia

    2001-01-01

    LEP's last superconducting module leaves its home port... Just seven months into the operation, LEP dismantling is forging ahead. Two of the eight arcs which form the tunnel have already been emptied and the last of the accelerator's radiofrequency (RF) cavities has just been raised to the surface. The 160 people working on LEP dismantling have reason to feel pleased with their progress. All of the accelerator's 72 superconducting RF modules have already been brought to the surface, with the last one being extracted on 2nd May. This represents an important step in the dismantling process, as head of the project, John Poole, explains. 'This was the most delicate part of the project, because the modules are very big and they could only come out at one place', he says. The shaft at point 1.8 through which the RF cavity modules pass is 18 metres in diameter, while each module is 11.5 metres long. Some modules had to travel more than 10 kilometres to reach the shaft. ... is lifted up the PM 1.8 shaft, after a m...

  5. CAST reaches milestone but keeps on searching

    CERN Multimedia

    CERN Courier (september 2011 issue)

    2011-01-01

    After eight years of searching for the emission of a dark matter candidate particle, the axion, from the Sun, the CERN Axion Solar Telescope (CAST) has fulfilled its original physics programme.   Members of the CAST collaboration in July, together with dipole-based helioscope. CAST, the world’s most sensitive axion helioscope, points a recycled prototype LHC dipole magnet at the Sun at dawn and dusk, looking for the conversion of axions to X-rays. It incorporates four state-of-the-art X-ray detectors: three Micromegas detectors and a pn-CCD imaging camera attached to a focusing X-ray telescope that was recovered from the German space programme (see CERN Courier April 2010).  Over the years, CAST has operated with the magnet bores - the location of the axion conversion - in different conditions: first in vacuum, covering axion masses up to 20 meV/c2, and then with a buffer gas (4He and later 3He) at various densities, finally reaching the goal of 1.17 eV/c2 on 22 ...

  6. Important ATLAS Forward Calorimeter Milestone Reached

    CERN Document Server

    Loch, P.

    The ATLAS Forward Calorimeter working group has reached an important milestone in the production of their detectors. The mechanical assembly of the first electromagnetic module (FCal1C) has been completed at the University of Arizona on February 25, 2002, only ten days after the originally scheduled date. The photo shows the University of Arizona FCal group in the clean room, together with the assembled FCal1C module. The module consists of a stack of 18 round copper plates, each about one inch thick. Each plate is about 90 cm in diameter, and has 12260 precision-drilled holes in it, to accommodate the tube/rod electrode assembly. The machining of the plates, which was done at the Science Technology Center (STC) at Carleton University, Ottawa, Canada, required high precision to allow for easy insertion of the electrode copper tube. The plates have been carefully cleaned at the University of Arizona, to remove any machining residue and metal flakes. This process alone took about eleven weeks. Exactly 122...

  7. Access to expert stroke care with telemedicine: REACH MUSC

    Directory of Open Access Journals (Sweden)

    Abby Swanson Kazley

    2012-03-01

    Full Text Available Stroke is a leading cause of death and disability, and rtPA can significantly reduce the long-term impact of acute ischemic stroke (AIS if given within 3 hours of symptom onset. South Carolina is located in the stroke belt and has a high rate of stroke and stroke mortality. Many small rural SC hospitals do not maintain the expertise needed to treat AIS patients with rtPA. MUSC is an academic medical center using REACH MUSC telemedicine to deliver stroke care to 15 hospitals in the state, increasing the likelihood of timely treatment with rtPA. The purpose of this study is to determine the increase in access to rtPA through the use of telemedicine for AIS in the general population and in specific segments of the population based on age, gender, race, ethnicity, education, urban/rural residence, poverty, and stroke mortality.We used a retrospective cross-sectional design examining Census data from 2000 and Geographic Information Systems (GIS analysis to identify South Carolina residents that live within 30 or 60 minutes of a Primary Stroke Center (PSC or a REACH MUSC site. We include all South Carolina citizens in our analysis and specifically examine the population’s age, gender, race, ethnicity, education, urban/rural residence, poverty, and stroke mortality. Our sample includes 4,012,012 South Carolinians. The main measure is access to expert stroke care at a Primary Stroke Center (PSC or a REACH MUSC hospital within 30 or 60 minutes. We find that without REACH MUSC, only 38% of the population has potential access to expert stroke care in SC within sixty minutes given that most PSCs will maintain expert stroke coverage. REACH MUSC allows 76% of the population to be within sixty minutes of expert stroke care, and 43% of the population to be within 30 minute drive time of expert stroke care. These increases in access are especially significant for groups that have faced disparities in care and high rates of AIS. The use of telemedicine can

  8. Change in enzyme production by gradually drying culture substrate during solid-state fermentation.

    Science.gov (United States)

    Ito, Kazunari; Gomi, Katsuya; Kariyama, Masahiro; Miyake, Tsuyoshi

    2015-06-01

    The influence of drying the culture substrate during solid-state fermentation on enzyme production was investigated using a non-airflow box. The drying caused a significant increase in enzyme production, while the mycelium content decreased slightly. This suggests that changes in the water content in the substrate during culture affect enzyme production in fungi. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  9. Extending the Reach of Statistical Software Testing

    National Research Council Canada - National Science Library

    Weber, Robert

    2004-01-01

    .... In particular, as system complexity increases, the matrices required to generate test cases and perform model analysis can grow dramatically, even exponentially, overwhelming the test generation...

  10. Device for mechanoluminescence excitation by applying gradually varying pressure on the sample

    International Nuclear Information System (INIS)

    Rai, R.K.; Kher, R.S.; Upadhyay, A.K.; Dhoble, S.J.; Khan, S.A.

    2011-01-01

    Mechanoluminescence (ML) is an interesting phenomenon, which is a light emission caused by mechanical stimuli such as grinding, cutting, collision, striking, friction etc. The nature of the ML emitted from a particular material depends upon how the materials are deformed. The compression technique and piston impact or impulsive techniques are the most popular for ML measurement. In these techniques, ML is excited by applying certain fixed load on to the sample and, it is not possible to study ML by continuously varying load on to the sample. Therefore in order to study ML by applying continuously increasing/decreasing pressure on the sample, a low cost set up has been designed and developed. We have compared the ML of sugar (non-irradiated), γ-irradiated LiF:Ba and BaAl 2 O 4 :Eu phosphor, when ML is excited impulsively and by applying continuously varying pressure on the sample. When BaAl 2 O 4 :Eu phosphor is deformed impulsively, a single peak with shoulder is observed in the time versus ML intensity curve, while number of peak is observed, when continuously increasing pressure applied on the sample. When pressure is continuously decreased less number of peaks is observed as compared to that of increasing pressure. Similar result is observed for LiF:Ba crystal. The enhancement in ML intensity with γ-irradiation suggest that the BaAl 2 O 4 :Eu is a suitable candidate for ML dosimetry. (author)

  11. The environmental paradox in generation: How South America is gradually becoming more dependent on thermal generation

    International Nuclear Information System (INIS)

    Arango, Santiago; Larsen, Erik R.

    2010-01-01

    There has been an increasing focus on global warming, emission of green house gases (GHG), and the problems this might create. In this article, we review the trend in sustainable and renewable electricity generation in South America, where the generation portfolio increasingly depends on thermal generation, in particular gas. South America is a region that has relatively low emissions, but the current development is not desirable in environmental terms. We analyze the underlying reasons for this development, which is related to security of supply, deregulation, and the cost of renewable energy. We review and discuss the policies to promote renewables in the region. We analyze the potential advantages and drawbacks of different types of market interventions, such as direct subsidies that create potentially strong market distortions, more sophisticated market interventions that might be less intrusive but not necessarily as effective as, e.g. firm energy markets. We also review market-based solutions such as the Clean Market Mechanism and its potential, and the use of renewable electricity in non-interconnected zones, which might be one of the most economically attractive applications of renewables. However, without a stronger and more aggressive intervention from the governments in the region it is unlikely that the increase in thermal generation can be stopped. (author)

  12. Induction of a gradual, reversible morphogenesis of its host's epithelial brush border by Vibrio fischeri.

    Science.gov (United States)

    Lamarcq, L H; McFall-Ngai, M J

    1998-02-01

    Bacteria exert a variety of influences on the morphology and physiology of animal cells whether they are pathogens or cooperative partners. The association between the luminous bacterium Vibrio fischeri and the sepiolid squid Euprymna scolopes provides an experimental model for the study of the influence of extracellular bacteria on the development of host epithelia. In this study, we analyzed bacterium-induced changes in the brush borders of the light organ crypt epithelia during the initial hours following colonization of this tissue. Transmission electron microscopy of the brush border morphology in colonized and uncolonized hosts revealed that the bacteria effect a fourfold increase in microvillar density over the first 4 days of the association. Estimates of the proportions of bacterial cells in contact with host microvilli showed that the intimacy of the bacterial cells with animal cell surfaces increases significantly during this time. Antibiotic curing of the organ following colonization showed that sustained interaction with bacteria is essential for the retention of the induced morphological changes. Bacteria that are defective in either light production or colonization efficiency produced changes similar to those by the parent strain. Conventional fluorescence and confocal scanning laser microscopy revealed that the brush border is supported by abundant filamentous actin. However, in situ hybridization with beta-actin probes did not show marked bacterium-induced increases in beta-actin gene expression. These experiments demonstrate that the E. scolopes-V. fischeri system is a viable model for the experimental study of bacterium-induced changes in host brush border morphology.

  13. Trends in radionuclide concentrations in Hanford Reach fish, 1982 through 1992

    International Nuclear Information System (INIS)

    Poston, T.M.

    1994-06-01

    Environmental monitoring has been conducted at the US Department of Energy's Hanford Site in southeast Washington State since 1945. Fish from the Hanford Reach of the Columbia River, which borders the Site, are monitored annually. The two objectives of this report were (1) to evaluate trends in the concentrations of radionuclides [e.g., 90 Sr and 137 Cs] in two species of Columbia River fish [smallmouth bass and mountain whitefish] sampled from the Hanford Reach from 1982 through 1992; and (2) to determine the impact of Hanford Site releases on these two species and carp and fall chinook salmon collected during this time frame. The evaluation found gradual reductions of 137 Cs in bass muscle and 90 Sr in bass and whitefish carcass from 1982 through 1992. Concentrations of 90 Sr in bass and whitefish followed the pattern established by reported Hanford Site releases from 1982 through 1992 and was supported by significant regression analyses comparing annual releases to sample concentration. Because data for carp have been collected only since 1990, the data base was inadequate for determining trends. Moreover, fall chinook salmon were only sampled once in this 11-year period. Concentrations of 90 Sr and 137 Cs in fish samples collected from distant background locations exceeded concentrations in Hanford Reach fish. Estimates of the dose from consumption of Hanford Reach fish were less than 0.001 times the National Council on Radiation Protection and Measurements and the US Department of Energy guideline of 100 mrem/yr

  14. Planning of the Extended Reach well Dieksand 2; Planung der Extended Reach Bohrung Dieksand 2

    Energy Technology Data Exchange (ETDEWEB)

    Frank, U.; Berners, H. [RWE-DEA AG, Hamburg (Germany). Drilling Team Mittelplate und Dieksand; Hadow, A.; Klop, G.; Sickinger, W. [Wintershall AG Erdoelwerke, Barnstdorf (Germany); Sudron, K.

    1998-12-31

    The Mittelplate oil field is located 7 km offshore the town of Friedrichskoog. Reserves are estimated at 30 million tonnes of oil. At a production rate of 2,500 t/d, it will last about 33 years. The transport capacity of the offshore platform is limited, so that attempts were made to enhance production by constructing the extended reach borehole Dieksand 2. Details are presented. (orig.) [Deutsch] Das Erdoelfeld Mittelplate liegt am suedlichen Rand des Nationalparks Schleswig Holsteinisches Wattenmeer, ca. 7000 m westlich der Ortschaft Friedrichskoog. Die gewinnbaren Reserven betragen ca. 30 Millionen t Oel. Bei einer Foerderkapazitaet von 2.500 t/Tag betraegt die Foerderdauer ca. 33 Jahre. Aufgrund der begrenzten Transportkapazitaeten von der Insel, laesst sich durch zusaetzliche Bohrungen von der kuenstlichen Insel Mittelplate keine entscheidende Erhoehung der Foerderkapazitaet erzielen. Ab Sommer 1996 wurde erstmals die Moeglichkeit der Lagerstaettenerschliessung von Land untersucht. Ein im Mai 1997 in Hamburg etabliertes Drilling Team wurde mit der Aufgabe betraut, die Extended Reach Bohrung Dieksand 2 zu planen und abzuteufen. Die Planungsphasen fuer die Extended Reach Bohrung Dieksand 2 wurden aufgezeigt. Die fuer den Erfolg einer Extended Reach Bohrung wichtigen Planungsparameter wurden erlaeutert. Es wurden Wege gezeigt, wie bei diesem Projekt technische und geologische Risiken in der Planung mit beruecksichtigt und nach Beginn der Bohrung weiter bearbeitet werden koennen. (orig.)

  15. Broadband absorption and enhanced photothermal conversion property of octopod-like Ag@Ag2S core@shell structures with gradually varying shell thickness.

    Science.gov (United States)

    Jiang, Qian; Zeng, Wenxia; Zhang, Canying; Meng, Zhaoguo; Wu, Jiawei; Zhu, Qunzhi; Wu, Daxiong; Zhu, Haitao

    2017-12-19

    Photothermal conversion materials have promising applications in many fields and therefore they have attracted tremendous attention. However, the multi-functionalization of a single nanostructure to meet the requirements of multiple photothermal applications is still a challenge. The difficulty is that most nanostructures have specific absoprtion band and are not flexible to different demands. In the current work, we reported the synthesis and multi-band photothermal conversion of Ag@Ag 2 S core@shell structures with gradually varying shell thickness. We synthesized the core@shell structures through the sulfidation of Ag nanocubes by taking the advantage of their spatially different reactivity. The resulting core@shell structures show an octopod-like mopgorlogy with a Ag 2 S bulge sitting at each corner of the Ag nanocubes. The thickness of the Ag 2 S shell gradually increases from the central surface towards the corners of the structure. The synthesized core@shell structures show a broad band absorption spectrum from 300 to 1100 nm. Enhanced photothermal conversion effect is observed under the illuminations of 635, 808, and 1064 nm lasers. The results indicate that the octopod-like Ag@Ag 2 S core@shell structures have characteristics of multi-band photothermal conversion. The current work might provide a guidance for the design and synthesis of multifunctional photothermal conversion materials.

  16. Ageing as a price of cooperation and complexity: self-organization of complex systems causes the gradual deterioration of constituent networks.

    Science.gov (United States)

    Kiss, Huba J M; Mihalik, Agoston; Nánási, Tibor; Ory, Bálint; Spiró, Zoltán; Soti, Csaba; Csermely, Peter

    2009-06-01

    The network concept is increasingly used for the description of complex systems. Here, we summarize key aspects of the evolvability and robustness of the hierarchical network set of macromolecules, cells, organisms and ecosystems. Listing the costs and benefits of cooperation as a necessary behaviour to build this network hierarchy, we outline the major hypothesis of the paper: the emergence of hierarchical complexity needs cooperation leading to the ageing (i.e. gradual deterioration) of the constituent networks. A stable environment develops cooperation leading to over-optimization, and forming an 'always-old' network, which accumulates damage, and dies in an apoptosis-like process. A rapidly changing environment develops competition forming a 'forever-young' network, which may suffer an occasional over-perturbation exhausting system resources, and causing death in a necrosis-like process. Giving a number of examples we demonstrate how cooperation evokes the gradual accumulation of damage typical to ageing. Finally, we show how various forms of cooperation and consequent ageing emerge as key elements in all major steps of evolution from the formation of protocells to the establishment of the globalized, modern human society.

  17. [Analysis of the results of bone healing in femurs lengthened by the gradual distraction method in children and adolescents].

    Science.gov (United States)

    Jochymek, J; Skvaril, J; Ondrus, S

    2009-10-01

    Treatment of leg length inequality via lengthening of the shorter extremity is an infrequent orthopedic procedure due to the requirement of special distraction devices and possible serious complications. Essential qualitative changes in operative technique development are associated with the name of G. A. Ilizarov, who paved the way for the autoregenerate gradual distraction method in the 1950s. In the years 1990 through 2007 a total of 67 patients underwent femur lengthening via gradual distraction using various types of external fixators at the Department of Pediatric Surgery, Orthopedics, and Traumatology, Faculty Hospital in Brno. The quality of bone healing was monitored and a number of parameters followed and statistically evaluated using regularly scheduled X-ray examinations. In 13 cases we had to remove the external fixator following the distraction phase, perform an osteosynthesis via a splint and fill the distraction gap via spongioplasty. The bone healing was satisfactory in the remaining 54 patients and the lengthened bone required no other fixation method. The analysis showed statistically significant deceleration in bone healing following distraction in female patients over 12 years of age, and in boys over 14 years of age. Lack of periosteal callus five weeks after surgery always signified serious problems in further healing. Severe complications were recorded in 11 cases during the distraction phase, and in 12 cases after the removal of the distraction apparatus. Our results fully correspond with the data and experience of others cited authors. In addition our study showed deceleration in bone healing in girls over 12 years and in boys over 14 years of age and serious problem in healing when is lack of periostal callus five weeks after surgery. The aim of this report was to present the results of our study of distraction gap bone healing using the gradual lengthening approach. Key words: leg lengthening, gradual distraction, external fixation, leg

  18. Final results of the gradual reconstruction of Bohunice VI in Slovakia and evaluation of the reconstruction by international missions

    International Nuclear Information System (INIS)

    Ferenc, M.

    2001-01-01

    The gradual reconstruction of the Bohunice V1 nuclear power plant (Slovakia) represents the most extensive reconstruction of a nuclear power plant in operation as implemented worldwide up to now. Extensive reconstruction works in both civil construction and process parts, in instrumentation and control part, and in electric part enhanced both nuclear safety and operational reliability of Bohunice V1 in a significant way.(author)

  19. GROWTH PERFORMANCE AND CARCASS COMPOSITION OF RABBITS FED ON DIETS OF GRADUAL LEVELS OF BARLEY GRAIN

    Directory of Open Access Journals (Sweden)

    M.M. El-Adawy

    2012-05-01

    Full Text Available Forty-eight male New Zealand White rabbits of 6 weeks age (BW 875 ± 28.3 g were randomly allocated among six groups in different levels of barley grains (BG; 0 (B0, 5 (B5, 10 (B10, 15 (B15, 20 (B20, 25% (B25 of the total diet on growth performance and carcass composition of rabbits . The highest live BW value (P < 0.05 was obtained in B20 rabbits, whereas the highest feed intake (P < 0.05 value was obtained in B25 rabbits followed by those fed on the other diets. The better-feed conversion ratio (FCR was obtained in B20 rabbits followed by those of B15 and B25. Animals of B20 had better FCR than those of the other experimental diets. The relative contribution of soft feces to dry matter or crude protein intake differed (P < 0.05 among the experimental diets. The caecal turnover rate was increased (P < 0.05 in B15 and B20 rabbits than those other diets. The per-slaughter weight, hot and cold carcass weight and dressing percentage were differed (P < 0.05 among the experimental groups and highest values were recorded in B20 rabbits. Data suggested that a partial replacement of corn grains (CG by 20% BG in rabbit diets was increased live body weight, feed intake and feed conversion ratio.

  20. Can coronal hole spicules reach coronal temperatures?

    Science.gov (United States)

    Madjarska, M. S.; Vanninathan, K.; Doyle, J. G.

    2011-08-01

    Aims: The present study aims to provide observational evidence of whether coronal hole spicules reach coronal temperatures. Methods: We combine multi-instrument co-observations obtained with the SUMER/SoHO and with the EIS/SOT/XRT/Hinode. Results: The analysed three large spicules were found to be comprised of numerous thin spicules that rise, rotate, and descend simultaneously forming a bush-like feature. Their rotation resembles the untwisting of a large flux rope. They show velocities ranging from 50 to 250 kms-1. We clearly associated the red- and blue-shifted emissions in transition region lines not only with rotating but also with rising and descending plasmas. Our main result is that these spicules although very large and dynamic, are not present in the spectral lines formed at temperatures above 300 000 K. Conclusions: In this paper we present the analysis of three Ca ii H large spicules that are composed of numerous dynamic thin spicules but appear as macrospicules in lower resolution EUV images. We found no coronal counterpart of these and smaller spicules. We believe that the identification of phenomena that have very different origins as macrospicules is due to the interpretation of the transition region emission, and especially the He ii emission, wherein both chromospheric large spicules and coronal X-ray jets are present. We suggest that the recent observation of spicules in the coronal AIA/SDO 171 Å and 211 Å channels probably comes from the existence of transition region emission there. Movie is available in electronic form at http://www.aanda.org

  1. Valley detection using a graphene gradual pn junction with spin–orbit coupling: An analytical conductance calculation

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Mou, E-mail: yang.mou@hotmail.com [Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006 (China); Wang, Rui-Qiang [Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006 (China); Bai, Yan-Kui [College of Physical Science and Information Engineering and Hebei Advance Thin Films Laboratory, Hebei Normal University, Shijiazhuang, Hebei 050024 (China)

    2015-09-04

    Graphene pn junction is the brick to build up variety of graphene nano-structures. The analytical formula of the conductance of graphene gradual pn junctions in the whole bipolar region has been absent up to now. In this paper, we analytically calculated that pn conductance with the spin–orbit coupling and stagger potential taken into account. Our analytical expression indicates that the energy gap causes the conductance to drop a constant value with respect to that without gap in a certain parameter region, and manifests that the curve of the conductance versus the stagger potential consists of two Gaussian peaks – one valley contributes one peak. The latter feature allows one to detect the valley polarization without using double-interface resonant devices. - Highlights: • Analytical conductance formula of the gradual graphene pn junction with spin–orbit coupling in the whole bipolar region. • Exploring the valley-dependent transport of gradual graphene pn junctions analytically. • Conductance peak without resonance.

  2. Current status of and problems in ice heat storage systems contribution to improving load rate. Contracts on Eco-Ice reached 240 cases by October 1997, an increase of 1.5 times over the same period of the previous year (Chubu Electric Power Co. Inc.); Fukaritsu kaizen ni kokensuru kori chikunetsu system no genjo to kadai. 1997 nendo 10 gatsu made no ekoaisu seiyaku wa 240 ken de tai zennen dokihi 1.5bai (Chubu Denryoku)

    Energy Technology Data Exchange (ETDEWEB)

    Urata, M. [Chubu Electric Power Co. Inc., Nagoya (Japan)

    1998-02-01

    This paper introduces activities performed by Chubu Electric Power Co., Inc. on ice heat storage air conditioning systems. Chubu Electric Power has worked with concerted efforts particularly on proliferation of an ice heat storage type air conditioning system, called `Eco-Ice`. A `heat storage air conditioner group` has been established in the sales department of the head office, and `market development groups` in branch offices to advance the recommendation activities. The Eco-Ice has been publicized on TV commercials, and the `97 Electric Power Heat Storage Air Conditioning Fair was held. Individual discrete type models were added to the product line-up in fiscal 1995. In addition, because of the system economy having been improved as a result of the improvements in the governmental subsidy system, power charge system, and support system, the number of Eco-Ice contracts is increasing rapidly. Two-hundred and forty Eco-Ice systems were contracted from April to October 1997, which means that peak shift capacity reached 7887 kW. Compared with the same period of fiscal 1996, the number of contract increased by 74 cases or 45% , and the peak shift capacity increased by 3148 kW or 66%. 4 figs.

  3. Responses of two températe evergreen Nothofagus species to sudden and gradual waterlogging: relationships with distribution patterns Respuestas de dos especies siempreverdes de Nothofagus al anegamiento gradual y repentino: relaciones con patrones de distribución

    Directory of Open Access Journals (Sweden)

    FRIDA PIPER

    2008-06-01

    Full Text Available The effects of gradual waterlogging on trees have been little studied. The températe evergreens Nothofagus nítida and N. dombeyi are differentially distributed on soil moisture gradients, only the former being common on poorly-drained sites. We compared the relative height growth rate (RGR H and foliage loss of seedlings subjected experimentally to normal drainage (soil at field capacity, sudden waterlogging and gradual waterlogging for two months to determine which waterlogging regime more accurately predicts interspecific differences in tolerance, as evident from natural distributions. RGR H was similar between species but differed between treatments (normal watering > gradual waterlogging = sudden waterlogging. Sudden waterlogging caused massive foliage loss in the two species, but gradual waterlogging caused much greater foliage loss in N. dombeyi than in N. nítida, indicating some degree of acclimation by the latter species. Linear regressions indicated that RGR H was negatively affected by foliage loss in both species, without differences between them. Since no difference in RGR H was found between species in the waterlogging treatments, but yet in foliage loss, other mechanisms may be in volved in the short term growth reduction of N. nítida. Effects of waterlogging on long-term performance in the field were evaluated by reciprocal transplants between a poorly-drained site naturally occupied by N. nítida, and a well drained site naturally occupied by N. dombeyi. After two growing seasons, N. dombeyi had significantly lower specific leaf área (SLA and RGR H, at the poorly drained site than at its original site. At the poorly drained site N. nítida achieved 100 % survival, compared with 73.5 % in N. dombeyi. Reduced growth and survival of N. dombeyi associated with the negative effects on carbón gain of extensive foliage loss and reduced SLA may thus exelude it from the wetter sites. We conclude that tolerance may be better

  4. Sugarcane Initial Growth with Vinasse Application in Latosol under Gradual Aluminum Stress

    Science.gov (United States)

    Marques Viglio, Larissa; Leal Varanda, Leticia; Soares, Marcio Roberto; Casagrande, José Carlos

    2015-04-01

    One of the strategies for overcoming the high acidity of soils and the consequent toxicity of aluminum (Al) is based on the use of varieties adapted to these conditions. In Brazil, the application of vinasse is routine practice in the cultivation of sugarcane due to its fertilizing effect, mainly because of high potassium content. However, the vinasse may also attenuate the toxic effects of Al in the soil by forming complexes with low molecular weight organic acids providing greater depth of the root of sugarcane. The aim of this work was to evaluate the effect of vinasse on the initial growth of three cultivars of sugarcane (RB855453, RB966928 and RB867515), as well as its influence on root depth in a Dystrophic Red-Yellow Latosol (Typic Hapludox) with gradient of saturation by Al. The experiment was conducted in a greenhouse, in totally randomized design with factorial arrangement and three replications. Seedlings of sugarcane were transplanted to PVC columns 0.8 m high, built by stacking four rings (0.2 m high), filled with soil samples, which offered an increasing gradient of saturation by Al (m%) at depth (0-0.2 m (m% = 0,7); 0.2-0.4 m (m% = 7,9); 0.4-0.6 m (m %= 40.8); 0.6-0.8 m (m%= 62.6)). The collection of the experiment was conducted 120 days after planting, with the determination of the stalk diameter (DC), plant height (ALT), leaf nutrient content, dry matter of the aerial part (MSPA) and dry matter of the root system (MSSR). Cultivars of sugarcane and the application of vinasse had effect on DC and the MSSR. Cultivar RB867515 showed higher DC than in other cultivars, with 20.8 mm. The increase of MSSR by sugarcane cultivars varied due to depth. There were no effects of sugarcane cultivars and vinasse application in MSPA. The vinasse application resulted in plants with higher ALT. With the exception of the foliar content of Fe, the N, Ca, Mg, S and Mn content were below those considered appropriate for sugarcane. Unlike other cultivars, the application

  5. Reaching remote areas in Latin America.

    Science.gov (United States)

    Jaimes, R

    1994-01-01

    Poor communities in remote and inaccessible areas tend to not only be cut off from family planning education and services, but they are also deprived of basic primary health care services. Efforts to bring family planning to such communities and populations should therefore be linked with other services. The author presents three examples of programs to bring effective family planning services to remote communities in Central and South America. Outside of the municipal center in the Tuxtlas region of Mexico, education and health levels are low and people live according to ancient customs. Ten years ago with the help of MEXFAM, the IPPF affiliate in Mexico, two social promoters established themselves in the town of Catemaco to develop a community program of family planning and health care offering education and prevention to improve the quality of people's lives. Through their health brigades taking health services to towns without an established health center, the program has influenced an estimated 100,000 people in 50 villages and towns. The program also has a clinic. In Guatemala, the Family Welfare Association (APROFAM) gave bicycles to 240 volunteer health care workers to facilitate their outreach work in rural areas. APROFAM since 1988 has operated an integrated program to treat intestinal parasites and promote family planning in San Lucas de Toliman, an Indian town close to Lake Atitlan. Providing health care to more than 10,000 people, the volunteer staff has covered the entire department of Solola, reaching each family in the area. Field educators travel on motorcycles through the rural areas of Guatemala coordinating with the health volunteers the distribution of contraceptives at the community level. The Integrated Project's Clinic was founded in 1992 and currently carries out pregnancy and Pap tests, as well as general lab tests. Finally, Puna is an island in the middle of the Gulf of Guayaquil, Ecuador. Women on the island typically have 10

  6. Basic level category structure emerges gradually across human ventral visual cortex.

    Science.gov (United States)

    Iordan, Marius Cătălin; Greene, Michelle R; Beck, Diane M; Fei-Fei, Li

    2015-07-01

    Objects can be simultaneously categorized at multiple levels of specificity ranging from very broad ("natural object") to very distinct ("Mr. Woof"), with a mid-level of generality (basic level: "dog") often providing the most cognitively useful distinction between categories. It is unknown, however, how this hierarchical representation is achieved in the brain. Using multivoxel pattern analyses, we examined how well each taxonomic level (superordinate, basic, and subordinate) of real-world object categories is represented across occipitotemporal cortex. We found that, although in early visual cortex objects are best represented at the subordinate level (an effect mostly driven by low-level feature overlap between objects in the same category), this advantage diminishes compared to the basic level as we move up the visual hierarchy, disappearing in object-selective regions of occipitotemporal cortex. This pattern stems from a combined increase in within-category similarity (category cohesion) and between-category dissimilarity (category distinctiveness) of neural activity patterns at the basic level, relative to both subordinate and superordinate levels, suggesting that successive visual areas may be optimizing basic level representations.

  7. Effect of hypovolemia, infusion, and oral rehydration on gradual onset +Gz acceleration tolerance

    Science.gov (United States)

    Greenleaf, J. E.; Brock, P. J.; Haines, R. F.; Rositano, S. A.; Montgomery, L. D.; Keil, L. C.

    1976-01-01

    The purpose of this study was to determine the effect of blood withdrawal, blood infusion, and oral fluid intake on +Gz tolerance at an acceleration rate of 0.5 G/min. Six healthy men aged 21-27 yr were centrifuged after the withdrawal of 400 ml of blood (hypovolemia) from each man; they were centrifuged again following blood infusion (Phase I). Three weeks later the men were accelerated after similar hypovolemia and again after consuming 800 ml of an isotonic NaCl drink (Phase II). Phase I hypovolemia resulted in a reduction in tolerance in all subjects from a mean control level of 6.42 + or - 0.35 min to 5.45 + or - 0.17 min (-15.1%, p less than 0.05). Both infusion and drinking returned tolerances to control levels. During acceleration there were significant (p less than 0.05) increases in plasma vasopressin levels to 35 pg/ml; these were not influenced appreciably by infusion or drinking. In all acceleration runs there was an obligatory shift (loss) of plasma volume and electrolytes, especially potassium, regardless of the experimental treatments. Oral rehydration is shown to be as effective as blood replacement in restoring +Gz acceleration tolerance decrements due to hypovolemia.

  8. Evidence of gradual loss of precision for simple features and complex objects in visual working memory.

    Science.gov (United States)

    Rademaker, Rosanne L; Park, Young Eun; Sack, Alexander T; Tong, Frank

    2018-03-01

    Previous studies have suggested that people can maintain prioritized items in visual working memory for many seconds, with negligible loss of information over time. Such findings imply that working memory representations are robust to the potential contaminating effects of internal noise. However, once visual information is encoded into working memory, one might expect it to inevitably begin degrading over time, as this actively maintained information is no longer tethered to the original perceptual input. Here, we examined this issue by evaluating working memory for single central presentations of an oriented grating, color patch, or face stimulus, across a range of delay periods (1, 3, 6, or 12 s). We applied a mixture-model analysis to distinguish changes in memory precision over time from changes in the frequency of outlier responses that resemble random guesses. For all 3 types of stimuli, participants exhibited a clear and consistent decline in the precision of working memory as a function of temporal delay, as well as a modest increase in guessing-related responses for colored patches and face stimuli. We observed a similar loss of precision over time while controlling for temporal distinctiveness. Our results demonstrate that visual working memory is far from lossless: while basic visual features and complex objects can be maintained in a quite stable manner over time, these representations are still subject to noise accumulation and complete termination. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  9. Assessment of Surface Area Characteristics of Dental Implants with Gradual Bioactive Surface Treatment

    Science.gov (United States)

    Czan, Andrej; Babík, Ondrej; Miklos, Matej; Záušková, Lucia; Mezencevová, Viktória

    2017-10-01

    Since most of the implant surface is in direct contact with bone tissue, shape and integrity of said surface has great influence on successful osseointegration. Among other characteristics that predetermine titanium of different grades of pureness as ideal biomaterial, titanium shows high mechanical strength making precise miniature machining increasingly difficult. Current titanium-based implants are often anodized due to colour coding. This anodized layer has important functional properties for right usage and also bio-compatibility of dental implants. Physical method of anodizing and usage of anodizing mediums has a significant influence on the surface quality and itself functionality. However, basic requirement of the dental implant with satisfactory properties is quality of machined surface before anodizing. Roughness, for example, is factor affecting of time length of anodizing operation and so whole productivity. The paper is focused on monitoring of surface and area characteristics, such as roughness or surface integrity after different cutting conditions of miniature machining of dental implants and their impact on suitability for creation of satisfactory anodized layer with the correct biocompatible functional properties.

  10. A depleted ozone layer absorbs less UV-B, cooling the ozone layer, increasing the amount of UV-B observed to reach Earth, heating air by dissociating tropospheric and ground-level ozone, and heating oceans very efficiently by penetrating tens of meters into the mixed layer. UV-B is 48 times more energetic ("hotter") than IR absorbed by greenhouse gases

    Science.gov (United States)

    Ward, P. L.

    2017-12-01

    This new insight into the physics of radiation shows why changes in stratospheric ozone are observed to cause changes in global temperature. By 1970, manufactured CFC gases and ozone depletion began increasing. By 1993, increases in CFCs stopped as mandated by the Montreal Protocol. By 1995, increases in ozone depletion stopped. By 1998, increases in temperature stopped until 2014. Ozone is also depleted by halogen gases emitted from major basaltic lava flows, the largest of which, since 1783, occurred at Bardarbunga in Iceland in 2014, causing 2015 and 2016 to be the hottest years on record. Throughout Earth history, the largest basaltic lava flows were contemporaneous with periods of greatest warming and greatest levels of mass extinctions. Planck's empirical law shows that temperature of matter results from oscillation of all the bonds holding matter together. The higher the temperature, the higher the frequencies and amplitudes of oscillation. Thus, radiation from a nearby hotter body will make the absorbing body hotter than radiation from a cooler body. According to the Planck-Einstein relation, thermal energy (E) in matter and in radiation equals frequency of oscillation (ν) times the Planck constant (h), E=hν—the energy of a frictionless atomic oscillator. Since frequency is observed to be a very broad continuum extending from radio signals through visible light to gamma rays, thermal energy (E=hν) must also be a very broad continuum. Thermal flux cannot be represented properly by a single number of watts per square meter, as commonly assumed throughout the physical sciences, because all frequencies coexist and the number of watts increases with frequency. Thus, UV-B solar radiation is 48 times more energetic than IR terrestrial radiation absorbed by greenhouse gases and can make the absorbing body 48 times hotter. UV-B causes sunburn; no amount of IR can cause sunburn. Furthermore, in a basic experiment, I show that air containing more than 23 times

  11. Functional reach and lateral reach tests adapted for aquatic physical therapy

    Directory of Open Access Journals (Sweden)

    Ana Angélica Ribeiro de Lima

    Full Text Available Abstract Introduction: Functional reach (FR and lateral reach (LR tests are widely used in scientific research and clinical practice. Assessment tools are useful in assessing subjects with greater accuracy and are usually adapted according to the limitations of each condition. Objective: To adapt FR and LR tests for use in an aquatic environment and assess the performance of healthy young adults. Methods: We collected anthropometric data and information on whether the participant exercised regularly or not. The FR and LR tests were adapted for use in an aquatic environment and administered to 47 healthy subjects aged 20-30 years. Each test was repeated three times. Results: Forty-one females and six males were assessed. The mean FR test score for men was 24.06 cm, whereas the mean value for right lateral reach (RLR was 10.94 cm and for left lateral reach (LLR was 9.78 cm. For females, the mean FR score was 17.57 cm, while the mean values for RLR was 8.84cm and for LLR was 7.76 cm. Men performed better in the FR (p < 0.001 and RLR tests than women (p = 0.037. Individuals who exercised regularly showed no differences in performance level when compared with their counterparts. Conclusion: The FR and LR tests were adapted for use in an aquatic environment. Males performed better on the FR and RLR tests, when compared to females. There was no correlation between the FR and LR tests and weight, height, Body Mass Index (BMI, foot length or length of the dominant upper limb.

  12. Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells

    DEFF Research Database (Denmark)

    Sjövall, Fredrik; Morota, Saori; Persson, Johan Mikael

    2013-01-01

    to 7). Mitochondrial DNA (mtDNA), cytochrome c (Cyt c), and citrate synthase (CS) were measured as indicators of cellular mitochondrial content. RESULTS: In intact PBICs with endogenous substrates, a gradual increase in cellular respiration reached 173% of controls after 1 week (P = 0......INTRODUCTION: In sepsis, mitochondria have been associated with both initial dysfunction and subsequent upregulation (biogenesis). However, the evolvement of mitochondrial function in sepsis over time is largely unknown, and we therefore investigated mitochondrial respiration in peripheral blood.......001). In permeabilized cells, respiration using substrates of complex I, II, and IV were significantly increased days 1 to 2, reaching 137%, 130%, and 173% of controls, respectively. In parallel, higher levels of CS activity, mtDNA, and Cyt c content in PBICs (211%, 243%, and 331% of controls for the respective...

  13. Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC in preterm pigs.

    Directory of Open Access Journals (Sweden)

    Nada Ghoneim

    Full Text Available Enteral formula feeding is a risk factor for necrotizing enterocolitis (NEC in premature infants, yet studies are conflicting regarding the safest timing for introduction and advancement of feeds. Our aim was to test the effects of early vs. late initiation and abrupt vs. gradual advancement of enteral feeding of an intact vs. hydrolyzed protein formula on NEC incidence and severity in preterm pigs. In Experiment 1, preterm pigs received total parenteral nutrition (TPN at birth with abrupt initiation of enteral formula feeds (50% full intake on d of life (DOL 2 (EA or 5 (LA while PN continued. Pigs were also fed formula containing either intact or hydrolyzed protein. In Experiment 2, preterm pigs received TPN at birth with enteral, hydrolyzed-protein formula feeds introduced on DOL 2 either abruptly (EA; 50% full feeds or gradually (EG; 10-50% full feeds over 5 d while PN continued. NEC incidence and severity were assessed based on macroscopic and histological scoring. In Experiment 1, NEC incidence (41% vs. 70%, P<0.05 and severity were reduced in LA vs. EA groups and LA was associated with a higher survival rate, daily weight gain and jejunum villus height. Piglets fed hydrolyzed vs. intact protein formula had lower stomach content weights and similar NEC incidence. In Experiment 2, NEC incidence and severity were not different between pigs the EG vs. EA group. Proinflammatory gene expression (IL-1β, IL-6 and S100A9 in the ileum was lower in both LA and EG vs. EA groups. In conclusion, delayed initiation but not gradual advancement of enteral feeding is protective against NEC in preterm pigs. Feeding hydrolyzed vs. intact protein formula improved gastric transit without affecting the NEC incidence.

  14. Which Antidumping Cases Reach the WTO?

    DEFF Research Database (Denmark)

    Kokko, Ari; Tingvall, Patrik Gustavsson; Videnord, Josefin

    the different levels of disputes, as cases proceed from notifications to requests for consultations and third party adjudication at the WTO. The US is the main user of AD measures, as well as the main target for complaints at the WTO’s Dispute Settlement Body. However, emerging markets have increasingly started...... using AD law to protect their domestic firms. We find that the typical AD notification is submitted by an upper middle-income country, and it focuses on a medium low-technology industry with differentiated products, but low relationship-specificity. The most typical complainant at the WTO is also...

  15. Hard-magnetic surface layer effect on the erbium orthoferrite plate domain structure in the region of gradual spin reorientation

    International Nuclear Information System (INIS)

    Belyaeva, A.I.; Vojtsenya, S.V.; Yur'ev, V.P.

    1988-01-01

    Rearrangement of domain structures in the erbium orthoferrite plates with hard-magnetic surface layer is investigated during gradual spin reorientation. This phenomenon is explained by means of the proposed physical models. It is shown that in these plates an approach to the temperature interval of spin reorientation causes a decrease in the density of energy of domain walls separating the internal and surface domains. This decrease results in transition to the domain structure which are close to equilibrium ones inside the crystal. 30 refs.; 4 figs

  16. The focusing effect of electromagnetic waves in two-dimensional photonic crystals with gradually varying lattice constant

    Directory of Open Access Journals (Sweden)

    F Bakhshi Garmi

    2016-02-01

    Full Text Available In this paper we studied the focusing effect of electromagnetic wave in the two-dimensional graded photonic crystal consisting of Silicon rods in the air background with gradually varying lattice constant. The results showed that graded photonic crystal can focus wide beams on a narrow area at frequencies near the lower edge of the band gap, where equal frequency contours are not concave. For calculation of photonic band structure and equal frequency contours, we have used plane wave expansion method and revised plane wave expansion method, respectively. The calculation of the electric and magnetic fields was performed by finite difference time domain method.

  17. Discovery Reach for Black Hole Production

    CERN Document Server

    The ATLAS collaboration

    2009-01-01

    Models with extra space dimensions, in which our Universe exists on a 4-dimensional brane embedded in a higher dimensional bulk space-time, offer a new way to address outstanding problems in and beyond the Standard Model. In such models the Planck scale in the bulk can be of the order of the electroweak symmetry breaking scale. This allows the coupling strength of gravity to increase to a size similar to the other interactions, opening the way to the unification of gravity and the gauge interactions. The increased strength of gravity in the bulk space-time means that quantum gravity effects would be observable in the TeV energy range reachable by the LHC. The most spectacular phenomenon would be the production of black holes, which would decay semi-classically by Hawking radiation emitting high energy particles. In this note, we discuss the potential for the ATLAS experiment to discover such black holes in the early data (1--1000 pb$^{-1}$).

  18. IAEA Patient Protection Effort Reaches Key Milestone

    International Nuclear Information System (INIS)

    2012-01-01

    Full text: An International Atomic Energy Agency (IAEA) effort to help people track their radiation exposure from medical procedures achieved a significant milestone this week. The Agency received the final approval from a group of medical oversight organizations for the 'Joint Position Statement on the IAEA Patient Radiation Exposure Tracking', a set of principles to guide patient protection efforts at the sub-national, national, and international level. The joint statement endorses the IAEA's three-year-old Smart Card/SmartRadTrack project, which aims to help nations develop systems to track medical radiation procedures and radiation doses. The statement has been agreed by the World Health Organization (WHO), the U.S. Food and Drug Administration (FDA), the European Society of Radiology (ESR), the International Organization for Medical Physics (IOMP), the International Society of Radiographers and Radiological Technologists (ISRRT), and the Conference of Radiation Control Program Directors, USA (CRCPD). 'This system is critical if the medical community is going to keep patients safe when they are being referred for more and more diagnostic scans. These scans, over the years, are made using more and more powerful machines', said Madan Rehani, Radiation Safety Specialist in the IAEA's Radiation Protection of Patients Unit. 'The tracking system will draw doctors' attention to previous radiological examinations, both in terms of clinical information and radiation dose and thus help them assess whether the 11th or 20th CT scan is really appropriate, whether it will do more good than harm.' Advances in radiation-based diagnostic technologies, such as the CT scan, have led to patients receiving such procedures more frequently. The convenience of CT with the added advantage of increased information has resulted in increased usage to the point that there are instances of patients getting tens of CT scans in a few years, not all of which may be justified, or getting CT

  19. When the Brain Takes 'BOLD' Steps: Real-Time fMRI Neurofeedback Can Further Enhance the Ability to Gradually Self-regulate Regional Brain Activation.

    Science.gov (United States)

    Sorger, Bettina; Kamp, Tabea; Weiskopf, Nikolaus; Peters, Judith Caroline; Goebel, Rainer

    2018-05-15

    Brain-computer interfaces (BCIs) based on real-time functional magnetic resonance imaging (rtfMRI) are currently explored in the context of developing alternative (motor-independent) communication and control means for the severely disabled. In such BCI systems, the user encodes a particular intention (e.g., an answer to a question or an intended action) by evoking specific mental activity resulting in a distinct brain state that can be decoded from fMRI activation. One goal in this context is to increase the degrees of freedom in encoding different intentions, i.e., to allow the BCI user to choose from as many options as possible. Recently, the ability to voluntarily modulate spatial and/or temporal blood oxygenation level-dependent (BOLD)-signal features has been explored implementing different mental tasks and/or different encoding time intervals, respectively. Our two-session fMRI feasibility study systematically investigated for the first time the possibility of using magnitudinal BOLD-signal features for intention encoding. Particularly, in our novel paradigm, participants (n=10) were asked to alternately self-regulate their regional brain-activation level to 30%, 60% or 90% of their maximal capacity by applying a selected activation strategy (i.e., performing a mental task, e.g., inner speech) and modulation strategies (e.g., using different speech rates) suggested by the experimenters. In a second step, we tested the hypothesis that the additional availability of feedback information on the current BOLD-signal level within a region of interest improves the gradual-self regulation performance. Therefore, participants were provided with neurofeedback in one of the two fMRI sessions. Our results show that the majority of the participants were able to gradually self-regulate regional brain activation to at least two different target levels even in the absence of neurofeedback. When provided with continuous feedback on their current BOLD-signal level, most

  20. Characterisation of haematological profiles and whole blood relative gene expression levels in Holstein-Friesian and Jersey bull calves undergoing gradual weaning.

    Science.gov (United States)

    Johnston, D; Kenny, D A; Kelly, A K; McCabe, M S; McGee, M; Waters, S M; Earley, B

    2016-09-01

    Haematological profiles indicate the health status of an animal and can be used to identify sub-clinical stress responses. The objectives of the study were to examine (i) the effect of breed and plane of nutrition, on haematological profiles of artificially reared Holstein-Friesian and Jersey bull calves in response to gradual weaning, and (ii) the effect of breed on immune response genes in bovine whole blood using real-time quantitative PCR. Holstein-Friesian and Jersey bull calves were group housed indoors and individually fed using an automatic feeder. They were allocated to a high, medium or low plane of nutrition, based on milk replacer (MR) and concentrate. The nutrition treatments were calculated using National Research Council guidelines in order to achieve a high, medium or low growth rate for each respective breed. During the weaning phase MR was gradually reduced over a 14-day (d) period (d -13 to d 0). Calves were blood sampled on d -14, -6, -3, 0, 1, 3, 8 and 14 relative to weaning (d 0) for subsequent haematological analysis. On d -14, 1 and 8, a subset of eight Holstein-Friesian calves randomly selected from the medium nutrition treatment and eight Jersey calves randomly selected from the high nutrition treatment, were blood sampled for gene expression profiling, targeting biomarkers of weaning stress. These two treatment groups were chosen to examine the effect of breed on expression of the genes of interest, as energy intake and animal performance were similar. There was no effect of breed×plane of nutrition interaction nor effect of plane of nutrition on any variable measured (P>0.05). Gradual weaning produced differential biological responses in the two breeds evidenced by breed×time interactions for lymphocyte, monocyte and red blood cell number, plasma haemoglobin and haptoglobin concentrations (Plevel of the pro-apoptotic gene, Fas, increased on d 1 relative to d -14 (Plevels were greater in Jersey calves compared with Holstein-Friesian for

  1. Gradual training of alpacas to the confinement of metabolism pens reduces stress when normal excretion behavior is accommodated.

    Science.gov (United States)

    Lund, Kirrin E; Maloney, Shane K; Milton, John T B; Blache, Dominique

    2012-01-01

    Confinement in metabolism pens may provoke a stress response in alpacas that will reduce the welfare of the animal and jeopardize the validity of scientific results obtained in such pens. In this study, we tested a protocol designed to successfully train alpacas to be held in a specially designed metabolism pen so that the animals' confinement would not jeopardize their welfare. We hypothesized that the alpacas would show fewer behaviors associated with a response to stress as training gradually progressed, and that they would adapt to being in the confinement of the metabolism pen. The training protocol was successful at introducing alpacas to the metabolism pens, and it did reduce the incidence of behavioral responses to stress as the training progressed. The success of the training protocol may be attributed to the progressive nature of the training, the tailoring of the protocol to suit alpacas, and the use of positive reinforcement. This study demonstrated that both animal welfare and the validity of the scientific outcomes could be maximized by the gradual training of experimental animals, thereby minimizing the stress imposed on the animals during experimental procedures.

  2. The oriental fruit fly, Bactrocera dorsalis, in China: origin and gradual inland range expansion associated with population growth.

    Science.gov (United States)

    Wan, Xuanwu; Nardi, Francesco; Zhang, Bin; Liu, Yinghong

    2011-01-01

    The oriental fruit fly, Bactrocera dorsalis, expanded throughout mainland China in the last century to become one of the most serious pests in the area, yet information on this process are fragmentary. Three mitochondrial genes (nad1, cytb and nad5) were used to infer the genetic diversity, population structure and demographic history of the oriental fruit fly from its entire distribution range in China. High levels of genetic diversity, as well as a significant correspondence between genetic and geographic distances, suggest that the invasion process might have been gradual, with no associated genetic bottlenecks. Three population groups could be identified, nevertheless the overall genetic structure was weak. The effective number of migrants between populations, estimated using the coalescent method, suggested asymmetric gene flow from the costal region of Guangdong to most inland regions. The demographic analysis indicates the oriental fruit fly underwent a recent population expansion in the Central China. We suggest the species originated in the costal region facing the South China Sea and gradually expanded to colonize mainland China, expanding here to high population numbers.

  3. Gradual crossover in molecular organization of stable liquid H2O at moderately high pressure and temperature

    DEFF Research Database (Denmark)

    Koga, Yoshikata; Westh, Peter; Yoshida, Koh

    2014-01-01

    temperature. The extrapolated temperature to zero p seems to be about 70 – 80 °C for points X and 90 – 110 °C for Y. Furthermore, the mid-points of X and Y seem to extrapolate to the triple point of liquid, ice Ih and ice III. Recalling that the zero x Gly extrapolation of point X and Y for binary aqueous...... of the step named point X and its end point Y. In analogy with another third and fourth derivative pair in binary aqueous solutions of glycerol, dα p /dx Gly and d2 α p /dx Gly 2, at 0.1 MPa (α p is the thermal expansivity and x Gly the mole fraction of solute glycerol) in our recent publication [J. Solution...... Chem. 43, 663-674 (2014); DOI:10.1007/s10953-013-0122-7], we argue that there is a gradual crossover in the molecular organization of pure H2O from a low to a high p-regions starting at point X and ending at Y at a fixed T. The crossover takes place gradually spanning for about 100 MPa at a fixed...

  4. CERN safety reaches out to medicine

    CERN Document Server

    2001-01-01

    What do CERN and other scientific organizations like ESA and ESO have in common with neurosurgery and airlines? At first sight, not much. But all require sound safety management. CERN's expertise in this field was recently highlighted when two CERN engineers were invited to talk at an international conference on Quality Management and Risk Control in Neurosurgery.CERN has long been recognised as a centre of excellence in physics, and its spin-offs in fields such as medicine have been widely hailed. But increasingly, the Laboratory's expertise in the management of large international collaborations is also being recognised. Contacts between CERN and organizations like ESA and ESO, as well as with industry, bear witness to this fact. One recent example comes from Airbus Industrie, which organized a meeting in 1998 with CERN to compare notes on project management, safety, and quality assurance. Safety management is a recognised speciality in the field of project management and at CERN, TIS and the safety offici...

  5. Guaranteed performance in reaching mode of sliding mode ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    addresses the design of constant plus proportional rate reaching law-based SMC for second-order ... Reaching mode; sliding mode controlled systems; output tracking ... The uncertainty in the input distribution function g is expressed as.

  6. Nanomaterials under REACH. Nanosilver as a case study

    NARCIS (Netherlands)

    Pronk MEJ; Wijnhoven SWP; Bleeker EAJ; Heugens EHW; Peijnenburg WJGM; Luttik R; Hakkert BC; SEC; SIR; LER

    2009-01-01

    Om de risico's van nanomaterialen te kunnen inschatten en beheersen, zijn enkele aanpassingen nodig in de Europese chemicalienwetgeving REACH. De gegevens over stoffen waar REACH standaard om vraagt, zijn namelijk onvoldoende om de specifieke eigenschappen van nanomaterialen te bepalen. Hetzelfde

  7. Reaching Adolescents and Youth in Burkina Faso, Guinea-Bissau

    African Journals Online (AJOL)

    AJRH Managing Editor

    typical profile of individuals in contact with peer educators or attending youth ... being reached (versus not reached) by programs ... characteristics in order to serve groups that may be ... places for counseling services but the frequency of.

  8. Reaching Hard-to-Reach Individuals: Nonselective Versus Targeted Outbreak Response Vaccination for Measles

    Science.gov (United States)

    Minetti, Andrea; Hurtado, Northan; Grais, Rebecca F.; Ferrari, Matthew

    2014-01-01

    Current mass vaccination campaigns in measles outbreak response are nonselective with respect to the immune status of individuals. However, the heterogeneity in immunity, due to previous vaccination coverage or infection, may lead to potential bias of such campaigns toward those with previous high access to vaccination and may result in a lower-than-expected effective impact. During the 2010 measles outbreak in Malawi, only 3 of the 8 districts where vaccination occurred achieved a measureable effective campaign impact (i.e., a reduction in measles cases in the targeted age groups greater than that observed in nonvaccinated districts). Simulation models suggest that selective campaigns targeting hard-to-reach individuals are of greater benefit, particularly in highly vaccinated populations, even for low target coverage and with late implementation. However, the choice between targeted and nonselective campaigns should be context specific, achieving a reasonable balance of feasibility, cost, and expected impact. In addition, it is critical to develop operational strategies to identify and target hard-to-reach individuals. PMID:24131555

  9. Recovery of Three Arctic Stream Reaches From Experimental Nutrient Enrichment.

    Science.gov (United States)

    Green, A. C.; Benstead, J. P.; Deegan, L. A.; Peterson, B. J.; Bowden, W. B.; Huryn, A. D.; Slavik, K.; Hershey, A. E.

    2005-05-01

    We examined multi-year patterns in community recovery from experimental low-concentration nutrient (N+P and P only) enrichment in three reaches of two Arctic tundra streams (Kuparuk River and Oksrukuyik Creek) on the North Slope of Alaska (USA). Rates of recovery varied among community components and depended on duration of enrichment (2 to 13 consecutive growing seasons). Biomass and C:P ratio of epilithic algae returned to reference levels rapidly (within 2 years), regardless of enrichment duration. Bryophyte cover, which increased greatly after long-term enrichment (>8 years), recovered to reference levels only after 7 years, when a storm scoured most remnant moss in the recovering reach. Persistence of bryophytes slowed recovery rates of insect taxa that had either been positively (e.g., Ephemerella, most chironomid taxa) or negatively (e.g., Orthocladius rivulorum) affected by this shift in dominant primary producer and its consequence for benthic habitat. Growth of Arctic grayling (adults and young-of-year), the top predator, returned to reference rates within two years. Recovery of these Arctic stream ecosystems from nutrient enrichment was consequently controlled largely by interactions between duration of enrichment and physical disturbance, mediated through physical habitat shifts caused by bryophytes.

  10. From reaching every district to reaching every community: analysis and response to the challenge of equity in immunization in Cambodia

    Science.gov (United States)

    Chan Soeung, Sann; Grundy, John; Duncan, Richard; Thor, Rasoka; Bilous, Julian B

    2013-01-01

    Background An international review of the Cambodian Expanded Programme on Immunization (EPI) in 2010 and other data show that despite immunization coverage increases and vaccine preventable diseases incidence reductions, inequities in access to immunization services exist. Utilizing immunization and health systems literature, analysis of global health databases and the EPI review findings, this paper examines the characteristics of immunization access and outcome inequities, and describes proposed longer-term strategic and operational responses to these problems. Findings The national programme has evolved from earlier central and provincial level planning to strengthening routine immunization coverage through the District level ‘Reaching Every District Strategy’. However, despite remarkable improvements, the review found over 20% of children surveyed were not fully immunized, primarily from communities where inequities of both access and impact persist. These inequities relate mainly to socio-economic exposures including wealth and education level, population mobility and ethnicity. To address these problems, a shift in strategic and operational response is proposed that will include (a) a re-focus of planning on facility level to detect disadvantaged communities, (b) establishment of monitoring systems to provide detailed information on community access and utilization, (c) development of communication strategies and health networks that enable providers to adjust service delivery according to the needs of vulnerable populations, and (d) securing financial, management and political commitment for ‘reaching every community’. Conclusions For Cambodia to achieve its immunization equity objectives and disease reduction goals, a shift of emphasis to health centre and community is needed. This approach will maximize the benefits of new vaccine introduction in the coming ‘Decade of Vaccines’, plus potentially extend the reach of other life-saving maternal

  11. Dynamic channel adjustments in the Jingjiang Reach of the Middle Yangtze River

    Science.gov (United States)

    Xia, Junqiang; Deng, Shanshan; Lu, Jinyou; Xu, Quanxi; Zong, Quanli; Tan, Guangming

    2016-03-01

    Significant channel adjustments have occurred in the Jingjiang Reach of the Middle Yangtze River, because of the operation of the Three Gorges Project (TGP). The Jingjiang Reach is selected as the study area, covering the Upper Jingjiang Reach (UJR) and Lower Jingjiang Reach (LJR). The reach-scale bankfull channel dimensions in the study reach were calculated annually from 2002 to 2013 by means of a reach-averaged approach and surveyed post-flood profiles at 171 sections. We find from the calculated results that: the reach-scale bankfull widths changed slightly in the UJR and LJR, with the corresponding depths increasing by 1.6 m and 1.0 m the channel adjustments occurred mainly with respect to bankfull depth because of the construction of large-scale bank revetment works, although there were significant bank erosion processes in local regions without the bank protection engineering. The reach-scale bankfull dimensions in the UJR and LJR generally responded to the previous five-year average fluvial erosion intensity during flood seasons, with higher correlations being obtained for the depth and cross-sectional area. It is concluded that these dynamic adjustments of the channel geometry are a direct result of recent human activities such as the TGP operation.

  12. Passive reach and grasp with functional electrical stimulation and robotic arm support

    NARCIS (Netherlands)

    Westerveld, Ard J.; Schouten, Alfred C.; Veltink, Peter H.; van der Kooij, Herman

    2014-01-01

    Rehabilitation of arm and hand function is crucial to increase functional independence of stroke subjects. Here, we investigate the technical feasibility of an integrated training system combining robotics and functional electrical stimulation (FES) to support reach and grasp during functional

  13. How to increase reach efficiency and effectiveness of MEO’s digital marketing campaigns?

    OpenAIRE

    Fraga, Miguel

    2016-01-01

    Field lab: Business project This thesis report follows a Work Project (WP) developed at the leading Portuguese telco (MEO) on the topic of performance measurement of digital marketing (DM) display campaigns. The WP ought to solve issues such as lack of coordination, internal misinformation, data fragmentation and lack of return-centricity of MEO’s digital campaigns’ department. In the end, with a key focus on the use of Web Analytics, a concrete process for campaign ROI calculation was dev...

  14. Brazil: Increasing the Reach of the INIS Database by using Social Media

    International Nuclear Information System (INIS)

    Braga, Fabiane; Gama das Neves, Teodora Marly; Pereira, Diogo

    2015-01-01

    INIS began its activities in 1970 to collect and share scientific and technical information about the peaceful uses of nuclear science and technology, with participating nations collaborating to build a centralized database. In the same year, the Nuclear Information Center of the Brazilian Nuclear Energy Commission (CIN/CNEN) was created with the mission of representing Brazil in the INIS system. Since then it has played an important role in the context of Brazilian scientific and technological development as a database cooperative producer, a scientific and technical information service provider, and a knowledge generator, utilizing the INIS database. Since the 1970’s, CIN/CNEN has developed new information products and services based on the INIS database and produced in cooperation with other INIS Members, in order to support research in nuclear and related fields and to keep researchers updated on the newest publications in their areas of interest

  15. The long reach of Alzheimer's disease: patients, practice, and policy.

    Science.gov (United States)

    Bynum, Julie P W

    2014-04-01

    The impact of Alzheimer's disease and related dementias reaches well beyond the health care needs of the person with dementia. As dementia inexorably progresses, the patient becomes increasingly dependent on others for basic daily care and routine tasks, a physically safe environment, and protection from exploitation or abuse. Addressing the diverse medical and social care needs of the burgeoning US population with Alzheimer's disease and related dementias requires the adoption of a broad-based policy framework and agenda that explicitly acknowledge the complex and unique needs of people with dementia and the impacts of dementia on caregivers and society at large. Public policies related to social service providers, agencies that provide appropriate housing, financial and legal services, and law enforcement must complement other policies focused on prevention and risk reduction, effective treatment development, and efficient health care delivery.

  16. Reaching the global target to reduce stunting: an investment framework.

    Science.gov (United States)

    Shekar, Meera; Kakietek, Jakub; D'Alimonte, Mary R; Rogers, Hilary E; Eberwein, Julia Dayton; Akuoku, Jon Kweku; Pereira, Audrey; Soe-Lin, Shan; Hecht, Robert

    2017-06-01

    Childhood stunting, being short for one's age, has life-long consequences for health, human capital and economic growth. Being stunted in early childhood is associated with slower cognitive development, reduced schooling attainment and adult incomes decreased by 5-53%. The World Health Assembly has endorsed global nutrition targets including one to reduce the number of stunted children under five by 40% by 2025. The target has been included in the Sustainable Development Goals (SDG target 2.2). This paper estimates the cost of achieving this target and develops scenarios for generating the necessary financing. We focus on a key intervention package for stunting (KIPS) with strong evidence of effectiveness. Annual scale-up costs for the period of 2016-25 were estimated for a sample of 37 high burden countries and extrapolated to all low and middle income countries. The Lives Saved Tool was used to model the impact of the scale-up on stunting prevalence. We analysed data on KIPS budget allocations and expenditure by governments, donors and households to derive a global baseline financing estimate. We modelled two financing scenarios, a 'business as usual', which extends the current trends in domestic and international financing for nutrition through 2025, and another that proposes increases in financing from all sources under a set of burden-sharing rules. The 10-year financial need to scale up KIPS is US$49.5 billion. Under 'business as usual', this financial need is not met and the global stunting target is not reached. To reach the target, current financing will have to increase from US$2.6 billion to US$7.4 billion a year on average. Reaching the stunting target is feasible but will require large coordinated investments in KIPS and a supportive enabling environment. The example of HIV scale-up over 2001-11 is instructive in identifying the factors that could drive such a global response to childhood stunting. © The Author 2017. Published by Oxford University

  17. The ticking time bomb: Using eye-tracking methodology to capture attentional processing during gradual time constraints.

    Science.gov (United States)

    Franco-Watkins, Ana M; Davis, Matthew E; Johnson, Joseph G

    2016-11-01

    Many decisions are made under suboptimal circumstances, such as time constraints. We examined how different experiences of time constraints affected decision strategies on a probabilistic inference task and whether individual differences in working memory accounted for complex strategy use across different levels of time. To examine information search and attentional processing, we used an interactive eye-tracking paradigm where task information was occluded and only revealed by an eye fixation to a given cell. Our results indicate that although participants change search strategies during the most restricted times, the occurrence of the shift in strategies depends both on how the constraints are applied as well as individual differences in working memory. This suggests that, in situations that require making decisions under time constraints, one can influence performance by being sensitive to working memory and, potentially, by acclimating people to the task time gradually.

  18. Harmonic hopping, and both punctuated and gradual evolution of acoustic characters in Selasphorus hummingbird tail-feathers.

    Directory of Open Access Journals (Sweden)

    Christopher James Clark

    Full Text Available Models of character evolution often assume a single mode of evolutionary change, such as continuous, or discrete. Here I provide an example in which a character exhibits both types of change. Hummingbirds in the genus Selasphorus produce sound with fluttering tail-feathers during courtship. The ancestral character state within Selasphorus is production of sound with an inner tail-feather, R2, in which the sound usually evolves gradually. Calliope and Allen's Hummingbirds have evolved autapomorphic acoustic mechanisms that involve feather-feather interactions. I develop a source-filter model of these interactions. The 'source' comprises feather(s that are both necessary and sufficient for sound production, and are aerodynamically coupled to neighboring feathers, which act as filters. Filters are unnecessary or insufficient for sound production, but may evolve to become sources. Allen's Hummingbird has evolved to produce sound with two sources, one with feather R3, another frequency-modulated sound with R4, and their interaction frequencies. Allen's R2 retains the ancestral character state, a ∼1 kHz "ghost" fundamental frequency masked by R3, which is revealed when R3 is experimentally removed. In the ancestor to Allen's Hummingbird, the dominant frequency has 'hopped' to the second harmonic without passing through intermediate frequencies. This demonstrates that although the fundamental frequency of a communication sound may usually evolve gradually, occasional jumps from one character state to another can occur in a discrete fashion. Accordingly, mapping acoustic characters on a phylogeny may produce misleading results if the physical mechanism of production is not known.

  19. Development of reaching during mid-childhood from a Developmental Systems perspective.

    Science.gov (United States)

    Golenia, Laura; Schoemaker, Marina M; Otten, Egbert; Mouton, Leonora J; Bongers, Raoul M

    2018-01-01

    Inspired by the Developmental Systems perspective, we studied the development of reaching during mid-childhood (5-10 years of age) not just at the performance level (i.e., endpoint movements), as commonly done in earlier studies, but also at the joint angle level. Because the endpoint position (i.e., the tip of the index finger) at the reaching target can be achieved with multiple joint angle combinations, we partitioned variability in joint angles over trials into variability that does not (goal-equivalent variability, GEV) and that does (non-goal-equivalent variability, NGEV) influence the endpoint position, using the Uncontrolled Manifold method. Quantifying this structure in joint angle variability allowed us to examine whether and how spatial variability of the endpoint at the reaching target is related to variability in joint angles and how this changes over development. 6-, 8- and 10-year-old children and young adults performed reaching movements to a target with the index finger. Polynomial trend analysis revealed a linear and a quadratic decreasing trend for the variable error. Linear decreasing and cubic trends were found for joint angle standard deviations at movement end. GEV and NGEV decreased gradually with age, but interestingly, the decrease of GEV was steeper than the decrease of NGEV, showing that the different parts of the joint angle variability changed differently over age. We interpreted these changes in the structure of variability as indicating changes over age in exploration for synergies (a family of task solutions), a concept that links the performance level with the joint angle level. Our results suggest changes in the search for synergies during mid-childhood development.

  20. Action plans can interact to hinder or facilitate reach performance.

    Science.gov (United States)

    Fournier, Lisa R; Wiediger, Matthew D; Taddese, Ezana F

    2015-11-01

    Executing a reach action can be delayed while retaining another action in working memory (WM) if the two action plans partly overlap rather than do not overlap. This delay (partial repetition cost) occurs when reach responses are under cognitive control. In this study, we investigated whether facilitation (a partial repetition benefit) occurs when reach responses are automatic. We also examined whether the hemisphere controlling the limb or selection of the preferred limb (based on a free-reach task) influences reach performance when the actions partly overlap. Left- and right-handers reached to different stimulus locations to the left and right of body midline with their ipsilateral hand while maintaining an action plan in WM that required the same or the different hand. The results showed a partial repetition benefit for spatially compatible reaches to left and right stimulus locations far from the body midline, but not for those near the body midline. Also, no partial repetition cost was found at any of the stimulus-reach locations. This indicates that automatic reach responses that partly overlap with an action plan maintained in WM are not delayed, but instead can be facilitated (partial repetition benefit). The roles of hemisphere and reach-hand preference in action control and the importance of the degree of feature overlap in obtaining a partial repetition benefit (and cost) are discussed.

  1. Pilot study to test effectiveness of video game on reaching performance in stroke.

    Science.gov (United States)

    Acosta, Ana Maria; Dewald, Hendrik A; Dewald, Jules P A

    2011-01-01

    Robotic systems currently used in upper-limb rehabilitation following stroke rely on some form of visual feedback as part of the intervention program. We evaluated the effect of a video game environment (air hockey) on reaching in stroke with various levels of arm support. We used the Arm Coordination Training 3D system to provide variable arm support and to control the hockey stick. We instructed seven subjects to reach to one of three targets covering the workspace of the impaired arm during the reaching task and to reach as far as possible while playing the video game. The results from this study showed that across subjects, support levels, and targets, the reaching distances achieved with the reaching task were greater than those covered with the video game. This held even after further restricting the mapped workspace of the arm to the area most affected by the flexion synergy (effectively forcing subjects to fight the synergy to reach the hockey puck). The results from this study highlight the importance of designing video games that include specific reaching targets in the workspace compromised by the expression of the flexion synergy. Such video games would also adapt the target location online as a subject's success rate increases.

  2. Reach/frequency for printed media: Personal probabilities or models

    DEFF Research Database (Denmark)

    Mortensen, Peter Stendahl

    2000-01-01

    The author evaluates two different ways of estimating reach and frequency of plans for printed media. The first assigns reading probabilities to groups of respondents and calculates reach and frequency by simulation. the second estimates parameters to a model for reach/frequency. It is concluded ...... and estiamtes from such models are shown to be closer to panel data. the problem, however, is to get valid input for such models from readership surveys. Means for this are discussed....

  3. A New Neurocognitive Interpretation of Shoulder Position Sense during Reaching: Unexpected Competence in the Measurement of Extracorporeal Space

    Directory of Open Access Journals (Sweden)

    Teresa Paolucci

    2016-01-01

    Full Text Available Background. The position sense of the shoulder joint is important during reaching. Objective. To examine the existence of additional competence of the shoulder with regard to the ability to measure extracorporeal space, through a novel approach, using the shoulder proprioceptive rehabilitation tool (SPRT, during reaching. Design. Observational case-control study. Methods. We examined 50 subjects: 25 healthy and 25 with impingement syndrome with a mean age [years] of 64.52 +/− 6.98 and 68.36 +/− 6.54, respectively. Two parameters were evaluated using the SPRT: the integration of visual information and the proprioceptive afferents of the shoulder (Test 1 and the discriminative proprioceptive capacity of the shoulder, with the subject blindfolded (Test 2. These tasks assessed the spatial error (in centimeters by the shoulder joint in reaching movements on the sagittal plane. Results. The shoulder had proprioceptive features that allowed it to memorize a reaching position and reproduce it (error of 1.22 cm to 1.55 cm in healthy subjects. This ability was lower in the impingement group, with a statistically significant difference compared to the healthy group (p<0.05 by Mann–Whitney test. Conclusions. The shoulder has specific expertise in the measurement of the extracorporeal space during reaching movements that gradually decreases in impingement syndrome.

  4. Muscle activation patterns in acceleration-based phases during reach-to-grasp movement.

    Science.gov (United States)

    Tokuda, Keisuke; Lee, Bumsuk; Shiihara, Yasufumi; Takahashi, Kazuhiro; Wada, Naoki; Shirakura, Kenji; Watanabe, Hideomi

    2016-11-01

    [Purpose] An earlier study divided reaching activity into characteristic phases based on hand velocity profiles. By synchronizing muscle activities and the acceleration profile, a phasing approach for reaching movement, based on hand acceleration profiles, was attempted in order to elucidate the roles of individual muscle activities in the different phases of the acceleration profile in reaching movements. [Subjects and Methods] Ten healthy volunteer subjects participated in this study. The aim was to electromyographically evaluate muscles around the shoulder, the upper trapezius, the anterior deltoid, the biceps brachii, and the triceps brachii, most of which have been used to evaluate arm motion, as well as the acceleration of the upper limb during simple reaching movement in the reach-to-grasp task. [Results] Analysis showed the kinematic trajectories of the acceleration during a simple biphasic profile of the reaching movement could be divided into four phases: increasing acceleration (IA), decreasing acceleration (DA), increasing deceleration (ID), and decreasing deceleration (DD). Muscles around the shoulder showed different activity patterns, which were closely associated with these acceleration phases. [Conclusion] These results suggest the important role of the four phases, derived from the acceleration trajectory, in the elucidation of the muscular mechanisms which regulate and coordinate the muscles around the shoulder in reaching movements.

  5. The interactive effects of a gradual temperature decrease and long-term food deprivation on cardiac and hepatic blood flows in rainbow trout (Oncorhynchus mykiss).

    Science.gov (United States)

    Petersen, L H; Dzialowski, E; Huggett, D B

    2011-11-01

    The aim of the present study was to determine the extent to which the fish liver is perfused with blood. Transonic® flow probes were therefore implanted around the ventral aorta and hepatic vein(s) to record baseline blood flows in rainbow trout (Oncorhynchus mykiss) previously held under two different feeding regimes (food-deprived or fed to satiation, 8-12 weeks). Fish from both groups were exposed to a gradual temperature decrease (12°C to 5°C) and physical disturbance. Cardiac output (Q), stroke volume (Sv) and hepatic venous blood flow (HVBF) were significantly reduced in food-deprived trout at 12°C. Heart rate was not significantly affected by nutritional status, but was significantly reduced when temperature was decreased to 5°C. Physically disturbing each fish at 12°C and 5°C showed that the performance capacity of the heart was not affected by food deprivation as the capacity to increase Q and Sv was not reduced in the food-deprived group. Overall this study showed that food deprivation in rainbow trout reduced cardiac and hepatic blood flows. However, long-term food deprivation did not affect the capacity of the heart to acutely increase performance. Copyright © 2011. Published by Elsevier Inc.

  6. Investigation of PAM-4 for extending reach in data center interconnect applications

    DEFF Research Database (Denmark)

    Vegas Olmos, Juan José; Teipen, Brian; Eiselt, Nicklas

    2015-01-01

    Optical four-level pulse amplitude modulation (PAM-4) is being widely studied for various short-reach optical interfaces, motivated by the need to keep cost structure low, and to increase link capacity despite various constraints in component bandwidth. When considering PAM-4 in applications...... with reach significantly greater than 10km, such as in extended data center interconnects which require optical amplification, impairments such as chromatic dispersion, optical filtering, and ASE must be controlled. We investigate and report on requirements of PAM-4 for extended-reach, data center...

  7. Gradual crossover in molecular organization of stable liquid H2O at moderately high pressure and temperature

    Directory of Open Access Journals (Sweden)

    Yoshikata Koga

    2014-09-01

    Full Text Available Using the literature raw data of the speed of sound and the specific volume, the isothermal compressibility, κT, a second derivative thermodynamic quantity of G, was evaluated for liquid H2O in the pressure range up to 350 MPa and the temperature to 50 ºC. We then obtained its pressure derivative, dκT/dp, a third derivative numerically without using a fitting function to the κT data. On taking yet another p-derivative at a fixed T graphically without resorting to any fitting function, the resulting d2κT/dp2, a fourth derivative, showed a weak but clear step anomaly, with the onset of the step named point X and its end point Y. In analogy with another third and fourth derivative pair in binary aqueous solutions of glycerol, dαp/dxGly and d2αp/dxGly2, at 0.1 MPa (αp is the thermal expansivity and xGly the mole fraction of solute glycerol in our recent publication [J. Solution Chem. 43, 663-674 (2014; DOI:10.1007/s10953-013-0122-7], we argue that there is a gradual crossover in the molecular organization of pure H2O from a low to a high p-regions starting at point X and ending at Y at a fixed T. The crossover takes place gradually spanning for about 100 MPa at a fixed temperature. The extrapolated temperature to zero p seems to be about 70 – 80 °C for points X and 90 – 110 °C for Y. Furthermore, the mid-points of X and Y seem to extrapolate to the triple point of liquid, ice Ih and ice III. Recalling that the zero xGly extrapolation of point X and Y for binary aqueous glycerol at 0.1 MPa gives about the same T values respectively, we suggest that at zero pressure the region below about 70 °C the hydrogen bond network is bond-percolated, while above about 90 ºC there is no hydrogen bond network. Implication of these findings is discussed.

  8. NEW METHOD FOR REACHING CONSUMERS OVER THE INTERNET: "SEARCH ENGINE MARKETING”

    OpenAIRE

    Ergezer, Çağrı

    2018-01-01

    Internet has become a platform which reached millions of users momentarily with increased use, also become a place where people spent most of their time during the day by gaining consumer and potential customer ID in addition to just being ordinary Internet users. Search engines also have earned the distinction of being the preferred reference for users in the Internet sea which draws attention with usage rate and allowing you to easily reach the sought-after content where millions of content...

  9. Formation of Large-scale Coronal Loops Interconnecting Two Active Regions through Gradual Magnetic Reconnection and an Associated Heating Process

    Science.gov (United States)

    Du, Guohui; Chen, Yao; Zhu, Chunming; Liu, Chang; Ge, Lili; Wang, Bing; Li, Chuanyang; Wang, Haimin

    2018-06-01

    Coronal loops interconnecting two active regions (ARs), called interconnecting loops (ILs), are prominent large-scale structures in the solar atmosphere. They carry a significant amount of magnetic flux and therefore are considered to be an important element of the solar dynamo process. Earlier observations showed that eruptions of ILs are an important source of CMEs. It is generally believed that ILs are formed through magnetic reconnection in the high corona (>150″–200″), and several scenarios have been proposed to explain their brightening in soft X-rays (SXRs). However, the detailed IL formation process has not been fully explored, and the associated energy release in the corona still remains unresolved. Here, we report the complete formation process of a set of ILs connecting two nearby ARs, with successive observations by STEREO-A on the far side of the Sun and by SDO and Hinode on the Earth side. We conclude that ILs are formed by gradual reconnection high in the corona, in line with earlier postulations. In addition, we show evidence that ILs brighten in SXRs and EUVs through heating at or close to the reconnection site in the corona (i.e., through the direct heating process of reconnection), a process that has been largely overlooked in earlier studies of ILs.

  10. Effect of gradual weight-bearing on regenerated articular cartilage after joint distraction and motion in a rabbit model.

    Science.gov (United States)

    Nishino, Tomofumi; Ishii, Tomoo; Chang, Fei; Yanai, Takaji; Watanabe, Arata; Ogawa, Takeshi; Mishima, Hajime; Nakai, Kenjiro; Ochiai, Naoyuki

    2010-05-01

    The purpose of this study was to clarify the effect of gradual weight bearing (GWB) on regenerating cartilage. We developed a novel external fixation device (EFD) with a controllable weight-bearing system and continuous passive motion (CPM). A full-thickness defect was created by resection of the entire articular surface of the tibial plateau after the EFD was fixed in the rabbit's left knee. In the GWB group (n=6), GWB was started 6 weeks after surgery. In the CPM group (n=6), CPM with EFD was applied in the same manner without GWB. The control group (n=5) received only joint distraction. All rabbits were sacrificed 9 weeks after surgery. The central one-third of the regenerated tissue was assessed and scored blindly using a grading scale modified from the International Cartilage Repair Society visual histological assessment scale. The areas stained by Safranin-O and type II collagen antibody were measured, and the percentage of each area was calculated. There was no significant difference in the histological assessment scale among the groups. The percentage of the type II collagen-positive area was significantly larger in the GWB group than in the CPM group. The present study suggests that optimal mechanical stress, such as GWB, may affect regeneration of cartilage, in vivo. Copyright (c) 2009 Orthopaedic Research Society.

  11. Gradual and stepwise pyrolyses of insoluble organic matter from the Murchison meteorite revealing chemical structure and isotopic distribution

    Science.gov (United States)

    Okumura, Fumiaki; Mimura, Koichi

    2011-11-01

    To study the detailed structural and isotopic heterogeneity of the insoluble organic matter (IOM) of the Murchison meteorite, we performed two types of pyrolytic experiments: gradual pyrolysis and stepwise pyrolysis. The pyrolysates from the IOM contained 5 specific organic groups: aliphatic hydrocarbons, aromatic hydrocarbons, sulfur-bearing compounds, nitrogen-bearing compounds, and oxygen-bearing compounds. The release temperatures and the compositions of these pyrolysates demonstrated that the IOM is composed of a thermally unstable part and a thermally stable part. The thermally unstable part mainly served as the linkage and substituent portion that bound the thermally stable part, which was dispersed throughout the IOM. The linkage and substituent portion consisted of aliphatic hydrocarbons from C 4 to C 8, aromatic hydrocarbons with up to 6 rings, sulfo and thiol groups (the main reservoirs of sulfur in the IOM), and carboxyl and hydroxyl groups (the main reservoirs of oxygen). However, the thermally stable part was composed of polycyclic aromatic hydrocarbons (PAHs) containing nitrogen heterocycles in the IOM. Isotopic data showed that the aliphatic and aromatic hydrocarbons in the linkage and substituent portion were rich in D and 13C, while the thermally stable part was deficient in D and 13C. The structural and isotopic features suggested that the IOM was formed by mixing sulfur- and oxygen-bearing compounds rich in D and 13C (e.g., polar compounds in the interstellar medium (ISM)) and nitrogen-bearing PAHs deficient in D and 13C (e.g., polymerized compounds in the ISM).

  12. Gradual reduction of free sugars in beverages on sale by implementing the beverage checklist as a public health strategy.

    Science.gov (United States)

    Luger, Maria; Winzer, Eva; Schätzer, Manuel; Dämon, Sabine; Moser, Nadine; Blagusz, Karin; Rittmannsberger, Barbara; Schätzer, Julia; Lechleitner, Monika; Rieder, Anita; Hoppichler, Friedrich

    2018-03-15

    Sugar-sweetened beverages (SSBs) are a major source of free sugar intake and contribute to obesity and obesity-related diseases. Therefore, we analyzed the effect of a gradual sugar reduction strategy within the so-called 'beverage checklist' on free sugar content in beverages on sale in Austria. From 2010 until 2017, data on the amount of free sugar of sweetened beverages (sweetened with sugars, fruit juice and artificial sweeteners) with 0.20-0.75l serving sizes in all main supermarkets and from industry was collected. These data were published annually as the beverage checklist, which displays beverages on sale in Austria. The checklist aims to encourage beverage production with a free sugar content of ≤7.4 g/100 ml and no artificial sweeteners. Free sugar content in the total supply decreased significantly [7.53 (2.86) vs. 6.75 (2.79) g/100 ml; 10.4%; P strategy, conducted by a small non-profit organization, showed a reduction in the mean free sugar content by working with the industry to voluntarily reformulate beverages. More beverages with less added sugar were brought to the market, which implies healthier choices. The challenge now is to further engage the industry and also policy makers to achieve a greater reduction in the future.

  13. Gradual conversion of cellular stress patterns into pre-stressed matrix architecture during in vitro tissue growth.

    Science.gov (United States)

    Bidan, Cécile M; Kollmannsberger, Philip; Gering, Vanessa; Ehrig, Sebastian; Joly, Pascal; Petersen, Ansgar; Vogel, Viola; Fratzl, Peter; Dunlop, John W C

    2016-05-01

    The complex arrangement of the extracellular matrix (ECM) produced by cells during tissue growth, healing and remodelling is fundamental to tissue function. In connective tissues, it is still unclear how both cells and the ECM become and remain organized over length scales much larger than the distance between neighbouring cells. While cytoskeletal forces are essential for assembly and organization of the early ECM, how these processes lead to a highly organized ECM in tissues such as osteoid is not clear. To clarify the role of cellular tension for the development of these ordered fibril architectures, we used an in vitro model system, where pre-osteoblastic cells produced ECM-rich tissue inside channels with millimetre-sized triangular cross sections in ceramic scaffolds. Our results suggest a mechanical handshake between actively contracting cells and ECM fibrils: the build-up of a long-range organization of cells and the ECM enables a gradual conversion of cell-generated tension to pre-straining the ECM fibrils, which reduces the work cells have to generate to keep mature tissue under tension. © 2016 The Author(s).

  14. High-grade spondylolisthesis: gradual reduction using Magerl's external fixator followed by circumferential fusion technique and long-term results.

    Science.gov (United States)

    Karampalis, Christos; Grevitt, Michael; Shafafy, Masood; Webb, John

    2012-05-01

    To report the results of a cohort of patients treated with this technique high lighting radiological and functional outcomes, discussing also benefits arising from a gradual reduction procedure compared with other techniques. We evaluated nine patients who have undergone high-grade listhesis reduction and circumferential fusion at our institution from 1988 to 2006. Average length of follow-up was 11 years (5-19). Functional outcomes and radiological measurements were recorded and reported. Slip magnitude was reduced by an average of 2.9 grades (Meyerding classification). Slip angle improved by an average of 66% (p = 0.0001), lumbosacral angle by 47% (p = 0.0002), sacral rotation by 51% (p = 0.0068) and sacral inclination by 47% (p = 0.0055). At the latest follow-up 88.9% had achieved solid fusion. Post-operative 10-point Visual Analogue Score (VAS) for back pain had improved by 70% (p Average postoperative Oswestry Disability Index for all patients was 8% (range 0-16%) and that for Low Back Outcome Scores was 56.6 (range 44-70). All components of Short Form 36 Health Survey were greater than 80%. Overall patients' expectations were met in 100%. This is an effective and safe technique which addresses the lumbosacral kyphosis and cosmetic deformity without the neurological complications which accompany other reduction and fusion techniques for high-grade spondylolisthesis.

  15. Source Regions of the Interplanetary Magnetic Field and Variability in Heavy-Ion Elemental Composition in Gradual Solar Energetic Particle Events

    Science.gov (United States)

    Ko, Yuan-Kuen; Tylka, Allan J.; Ng, Chee K.; Wang, Yi-Ming; Dietrich, William F.

    2013-01-01

    Gradual solar energetic particle (SEP) events are those in which ions are accelerated to their observed energies by interactions with a shock driven by a fast coronal mass-ejection (CME). Previous studies have shown that much of the observed event-to-event variability can be understood in terms of shock speed and evolution in the shock-normal angle. But an equally important factor, particularly for the elemental composition, is the origin of the suprathermal seed particles upon which the shock acts. To tackle this issue, we (1) use observed solar-wind speed, magnetograms, and the PFSS model to map the Sun-L1 interplanetary magnetic field (IMF) line back to its source region on the Sun at the time of the SEP observations; and (2) then look for correlation between SEP composition (as measured by Wind and ACE at approx. 2-30 MeV/nucleon) and characteristics of the identified IMF-source regions. The study is based on 24 SEP events, identified as a statistically-significant increase in approx. 20 MeV protons and occurring in 1998 and 2003-2006, when the rate of newly-emergent solar magnetic flux and CMEs was lower than in solar-maximum years and the field-line tracing is therefore more likely to be successful. We find that the gradual SEP Fe/O is correlated with the field strength at the IMF-source, with the largest enhancements occurring when the footpoint field is strong, due to the nearby presence of an active region. In these cases, other elemental ratios show a strong charge-to-mass (q/M) ordering, at least on average, similar to that found in impulsive events. These results lead us to suggest that magnetic reconnection in footpoint regions near active regions bias the heavy-ion composition of suprathermal seed ions by processes qualitatively similar to those that produce larger heavy-ion enhancements in impulsive SEP events. To address potential technical concerns about our analysis, we also discuss efforts to exclude impulsive SEP events from our event sample.

  16. Association between imagined and actual functional reach (FR): a comparison of young and older adults.

    Science.gov (United States)

    Gabbard, Carl; Cordova, Alberto

    2013-01-01

    Recent studies indicate that the ability to mentally represent action using motor imagery declines with advanced age (>64 years). As the ability to represent action declines, the elderly may experience increasing difficulty with movement planning and execution. Here, we determined the association between estimation of reach via use of motor imagery and actual FR. Young adults (M=22 years) and older adults (M=66 years) estimated reach while standing with targets randomly presented in peripersonal (within actual reach) and extrapersonal (beyond reach) space. Imagined responses were compared to the individual's scaled maximum reach. FR, also while standing, was assessed using the standardized Functional Reach Test (FRT). Results for total score estimation accuracy showed that there was no difference for age; however, results for mean bias and distribution of error revealed that the older group underestimated while the younger group overestimated. In reference to FR, younger adults outperformed older adults (30 versus 14in.) and most prominent, only the younger group showed a significant relationship between estimation and FR. In addition to gaining insight to the effects of advanced age on the ability to mentally represent action and its association with movement execution, these results although preliminary, may have clinical implications based on the question of whether motor imagery training could improve movement estimations and how that might affect actual reach. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. An investigation of the neural circuits underlying reaching and reach-to-grasp movements: from planning to execution.

    Directory of Open Access Journals (Sweden)

    Chiara eBegliomini

    2014-09-01

    Full Text Available Experimental evidence suggests the existence of a sophisticated brain circuit specifically dedicated to reach-to-grasp planning and execution, both in human and non human primates (Castiello, 2005. Studies accomplished by means of neuroimaging techniques suggest the hypothesis of a dichotomy between a reach-to-grasp circuit, involving the intraparietal area (AIP, the dorsal and ventral premotor cortices (PMd and PMv - Castiello and Begliomini, 2008; Filimon, 2010 and a reaching circuit involving the medial intraparietal area (mIP and the Superior Parieto-Occipital Cortex (SPOC (Culham et al., 2006. However, the time course characterizing the involvement of these regions during the planning and execution of these two types of movements has yet to be delineated. A functional magnetic resonance imaging (fMRI study has been conducted, including reach-to grasp and reaching only movements, performed towards either a small or a large stimulus, and Finite Impulse Response model (FIR - Henson, 2003 was adopted to monitor activation patterns from stimulus onset for a time window of 10 seconds duration. Data analysis focused on brain regions belonging either to the reaching or to the grasping network, as suggested by Castiello & Begliomini (2008.Results suggest that reaching and grasping movements planning and execution might share a common brain network, providing further confirmation to the idea that the neural underpinnings of reaching and grasping may overlap in both spatial and temporal terms (Verhagen et al., 2013.

  18. Breakthrough Capability for UVOIR Space Astronomy: Reaching the Darkest Sky

    Science.gov (United States)

    Greenhouse, Matthew A.; Benson, Scott W.; Englander, Jacob; Falck, Robert D.; Fixsen, Dale J.; Gardner, Jonathan P.; Kruk, Jeffery W.; Oleson, Steven R.; Thronson, Harley A.

    2015-01-01

    We describe how availability of new solar electric propulsion (SEP) technology can substantially increase the science capability of space astronomy missions working within the near-UV to far-infrared (UVOIR) spectrum by making dark sky orbits accessible for the first time. We present two case studies in which SEP is used to enable a 700 kg Explorer-class and 7000 kg flagship-class observatory payload to reach an orbit beyond where the zodiacal dust limits observatory sensitivity. The resulting scientific performance advantage relative to a Sun-Earth L2 point (SEL2) orbit is presented and discussed. We find that making SEP available to astrophysics Explorers can enable this small payload program to rival the science performance of much larger long development-time systems. Similarly, we find that astrophysics utilization of high power SEP being developed for the Asteroid Redirect Robotics Mission (ARRM) can have a substantial impact on the sensitivity performance of heavier flagship-class astrophysics payloads such as the UVOIR successor to the James Webb Space Telescope.

  19. How Physics World reaches out in a digital age

    Science.gov (United States)

    Durrani, Matin

    Physics World is an award-winning international magazine that exists in print and digital formats. Exploiting the opportunities available with digital publishing and apps, our output has expanded hugely in recent years to include technology-linked focus issues, regional special reports on the likes of China, India, Mexico and Brazil, plus audio, video and interactive material too. This growth in content - and new media for presenting physics - reflects wider changes in communication. People increasingly want to access content in a manner and time of their choosing, seeking out information presented in a way that suits them and their needs. That can be challenging for physics communicators because it means tailoring your message to different audiences and the medium they are using. But it's exciting too as you can reach out to many more people into physics - and in many different ways - than was possible in the past. This talk outlines some principles of good communication, including telling a good story, bearing the reader, viewer or listener in mind, using appropriate media, keeping up with social media, and exploiting the power of video. But with new forms of communication constantly emerging, it's worth remembering there is no one ``right answer''.

  20. Proprioceptive body illusions modulate the visual perception of reaching distance.

    Directory of Open Access Journals (Sweden)

    Agustin Petroni

    Full Text Available The neurobiology of reaching has been extensively studied in human and non-human primates. However, the mechanisms that allow a subject to decide-without engaging in explicit action-whether an object is reachable are not fully understood. Some studies conclude that decisions near the reach limit depend on motor simulations of the reaching movement. Others have shown that the body schema plays a role in explicit and implicit distance estimation, especially after motor practice with a tool. In this study we evaluate the causal role of multisensory body representations in the perception of reachable space. We reasoned that if body schema is used to estimate reach, an illusion of the finger size induced by proprioceptive stimulation should propagate to the perception of reaching distances. To test this hypothesis we induced a proprioceptive illusion of extension or shrinkage of the right index finger while participants judged a series of LEDs as reachable or non-reachable without actual movement. Our results show that reach distance estimation depends on the illusory perceived size of the finger: illusory elongation produced a shift of reaching distance away from the body whereas illusory shrinkage produced the opposite effect. Combining these results with previous findings, we suggest that deciding if a target is reachable requires an integration of body inputs in high order multisensory parietal areas that engage in movement simulations through connections with frontal premotor areas.

  1. Environmental stressors afflicting tailwater stream reaches across the United States

    Science.gov (United States)

    Miranda, Leandro E.; Krogman, R. M.

    2014-01-01

    The tailwater is the reach of a stream immediately below an impoundment that is hydrologically, physicochemically and biologically altered by the presence and operation of a dam. The overall goal of this study was to gain a nationwide awareness of the issues afflicting tailwater reaches in the United States. Specific objectives included the following: (i) estimate the percentage of reservoirs that support tailwater reaches with environmental conditions suitable for fish assemblages throughout the year, (ii) identify and quantify major sources of environmental stress in those tailwaters that do support fish assemblages and (iii) identify environmental features of tailwater reaches that determine prevalence of key fish taxa. Data were collected through an online survey of fishery managers. Relative to objective 1, 42% of the 1306 reservoirs included in this study had tailwater reaches with sufficient flow to support a fish assemblage throughout the year. The surface area of the reservoir and catchment most strongly delineated reservoirs maintaining tailwater reaches with or without sufficient flow to support a fish assemblage throughout the year. Relative to objective 2, major sources of environmental stress generally reflected flow variables, followed by water quality variables. Relative to objective 3, zoogeography was the primary factor discriminating fish taxa in tailwaters, followed by a wide range of flow and water quality variables. Results for objectives 1–3 varied greatly among nine geographic regions distributed throughout the continental United States. Our results provide a large-scale view of the effects of reservoirs on tailwater reaches and may help guide research and management needs.

  2. Preschool Children’s Memory for Word Forms Remains Stable Over Several Days, but Gradually Decreases after Six Months

    Directory of Open Access Journals (Sweden)

    Katherine Ruth Gordon

    2016-09-01

    Full Text Available Research on word learning has focused on children’s ability to identify a target object when given the word form after a minimal number of exposures to novel word-object pairings. However, relatively little research has focused on children’s ability to retrieve the word form when given the target object. The exceptions involve asking children to recall and produce forms, and children typically perform near floor on these measures. In the current study, 3- to 5-year-old children were administered a novel test of word form that allowed for recognition memory and manual responses. Specifically, when asked to label a previously trained object, children were given three forms to choose from: the target, a minimally different form, and a maximally different form. Children demonstrated memory for word forms at three post-training delays: 10 minutes (short-term, 2 to 3 days (long-term, and 6 months to 1 year (very long-term. However, children performed worse at the very long-term delay than the other time points, and the length of the very long-term delay was negatively related to performance. When in error, children were no more likely to select the minimally different form than the maximally different form at all time points. Overall, these results suggest that children remember word forms that are linked to objects over extended post-training intervals, but that their memory for the forms gradually decreases over time without further exposures. Furthermore, memory traces for word forms do not become less phonologically specific over time; rather children either identify the correct form, or they perform at chance.

  3. Correlation Analyses Between the Characteristic Times of Gradual Solar Energetic Particle Events and the Properties of Associated Coronal Mass Ejections

    Science.gov (United States)

    Pan, Z. H.; Wang, C. B.; Wang, Yuming; Xue, X. H.

    2011-06-01

    It is generally believed that gradual solar energetic particles (SEPs) are accelerated by shocks associated with coronal mass ejections (CMEs). Using an ice-cream cone model, the radial speed and angular width of 95 CMEs associated with SEP events during 1998 - 2002 are calculated from SOHO/LASCO observations. Then, we investigate the relationships between the kinematic properties of these CMEs and the characteristic times of the intensity-time profile of their accompanied SEP events observed at 1 AU. These characteristic times of SEP are i) the onset time from the accompanying CME eruption at the Sun to the SEP arrival at 1 AU, ii) the rise time from the SEP onset to the time when the SEP intensity is one-half of peak intensity, and iii) the duration over which the SEP intensity is within a factor of two of the peak intensity. It is found that the onset time has neither significant correlation with the radial speed nor with the angular width of the accompanying CME. For events that are poorly connected to the Earth, the SEP rise time and duration have no significant correlation with the radial speed and angular width of the associated CMEs. However, for events that are magnetically well connected to the Earth, the SEP rise time and duration have significantly positive correlations with the radial speed and angular width of the associated CMEs. This indicates that a CME event with wider angular width and higher speed may more easily drive a strong and wide shock near to the Earth-connected interplanetary magnetic field lines, may trap and accelerate particles for a longer time, and may lead to longer rise time and duration of the ensuing SEP event.

  4. Filmes ópticos poliméricos fluorados com índice de refração gradual

    Directory of Open Access Journals (Sweden)

    Bartoli Julio R.

    1999-01-01

    Full Text Available Filmes finos de PMMA foram preparados a partir de solução e expostos ao plasma de CF4+H2, visando mudar o Índice de Refração (I.R. da superficie do PMMA através da fluoração. Os filmes de PMMA expostos ao plasma, denominados de filmes ópticos, foram caracterizados usando as técnicas: ESCA, RBS, FTIR, gravimetria, ângulo de contato, refratometria e elipsometria. Os resultados revelaram que as superfícies de PMMA foram revestidas com uma fina camada de hidrofluorcarbono polimérico, com espessuras variando entre 0,43 e 0,49mim. A camada de hidrofluorcarbono polimérico na superfície do PMMA foi responsável pela significante redução do seu I.R. de 1,49 para 1,43. A concentração de flúor nessa camada aumentou gradualmente em função da profundidade, sendo menor na sua superficie. Como o átomo de flúor é responsável pela redução do I.R., concluiu-se que o I.R. no revestimento fluorado do filme óptico variou também de forma gradual. A técnica de polimerização por plasma de CF4+H2 mostrou-se útil para modificar in situ os I.R. da superfíces de guias de ondas e fibras ópticas poliméricas, visando reduzir as perdas e aumentar a velocidade de transmissão de dados.

  5. Climate Resilience: Outreach and Engagement with Hard to Reach Communities

    Science.gov (United States)

    Baja, K.

    2017-12-01

    approaches to identify how residents and stakeholders became strategic implementation partners. It will also provide examples of successful community engagement using creative techniques in hard-to-reach areas, and demonstrate how buy-in from residents can advance action on resilience and increase community adaptive capacity.

  6. Flexion synergy overshadows flexor spasticity during reaching in chronic moderate to severe hemiparetic stroke.

    Science.gov (United States)

    Ellis, Michael D; Schut, Ingrid; Dewald, Julius P A

    2017-07-01

    Pharmaceutical intervention targets arm flexor spasticity with an often-unsuccessful goal of improving function. Flexion synergy is a related motor impairment that may be inadvertently neglected. Here, flexor spasticity and flexion synergy are disentangled to determine their contributions to reaching dysfunction. Twenty-six individuals participated. A robotic device systematically modulated shoulder abduction loading during ballistic reaching. Elbow muscle electromyography data were partitioned into windows delineated by elbow joint velocity allowing for the separation of synergy- and spasticity-related activation. Reaching velocity decreased with abduction loading (psynergy increased with abduction loading (psynergy is the predominant contributor to reaching dysfunction while flexor spasticity appears only relevant during unnaturally occurring passively supported movement. Interventions targeting flexion synergy should be leveraged in future stroke recovery trials. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

  7. Peer Support for the Hardly Reached: A Systematic Review.

    Science.gov (United States)

    Sokol, Rebeccah; Fisher, Edwin

    2016-07-01

    Health disparities are aggravated when prevention and care initiatives fail to reach those they are intended to help. Groups can be classified as hardly reached according to a variety of circumstances that fall into 3 domains: individual (e.g., psychological factors), demographic (e.g., socioeconomic status), and cultural-environmental (e.g., social network). Several reports have indicated that peer support is an effective means of reaching hardly reached individuals. However, no review has explored peer support effectiveness in relation to the circumstances associated with being hardly reached or across diverse health problems. To conduct a systematic review assessing the reach and effectiveness of peer support among hardly reached individuals, as well as peer support strategies used. Three systematic searches conducted in PubMed identified studies that evaluated peer support programs among hardly reached individuals. In aggregate, the searches covered articles published from 2000 to 2015. Eligible interventions provided ongoing support for complex health behaviors, including prioritization of hardly reached populations, assistance in applying behavior change plans, and social-emotional support directed toward disease management or quality of life. Studies were excluded if they addressed temporally isolated behaviors, were limited to protocol group classes, included peer support as the dependent variable, did not include statistical tests of significance, or incorporated comparison conditions that provided appreciable social support. We abstracted data regarding the primary health topic, categorizations of hardly reached groups, program reach, outcomes, and strategies employed. We conducted a 2-sample t test to determine whether reported strategies were related to reach. Forty-seven studies met our inclusion criteria, and these studies represented each of the 3 domains of circumstances assessed (individual, demographic, and cultural-environmental). Interventions

  8. Integration of QSAR models for bioconcentration suitable for REACH

    International Nuclear Information System (INIS)

    Gissi, Andrea; Nicolotti, Orazio; Carotti, Angelo; Gadaleta, Domenico; Lombardo, Anna; Benfenati, Emilio

    2013-01-01

    QSAR (Quantitative Structure Activity Relationship) models can be a valuable alternative method to replace or reduce animal test required by REACH. In particular, some endpoints such as bioconcentration factor (BCF) are easier to predict and many useful models have been already developed. In this paper we describe how to integrate two popular BCF models to obtain more reliable predictions. In particular, the herein presented integrated model relies on the predictions of two among the most used BCF models (CAESAR and Meylan), together with the Applicability Domain Index (ADI) provided by the software VEGA. Using a set of simple rules, the integrated model selects the most reliable and conservative predictions and discards possible outliers. In this way, for the prediction of the 851 compounds included in the ANTARES BCF dataset, the integrated model discloses a R 2 (coefficient of determination) of 0.80, a RMSE (Root Mean Square Error) of 0.61 log units and a sensitivity of 76%, with a considerable improvement in respect to the CAESAR (R 2 = 0.63; RMSE = 0.84 log units; sensitivity 55%) and Meylan (R 2 = 0.66; RMSE = 0.77 log units; sensitivity 65%) without discarding too many predictions (118 out of 851). Importantly, considering solely the compounds within the new integrated ADI, the R 2 increased to 0.92, and the sensitivity to 85%, with a RMSE of 0.44 log units. Finally, the use of properly set safety thresholds applied for monitoring the so called “suspicious” compounds, which are those chemicals predicted in proximity of the border normally accepted to discern non-bioaccumulative from bioaccumulative substances, permitted to obtain an integrated model with sensitivity equal to 100%. - Highlights: • Applying two independent QSAR models for bioconcentration factor increases the prediction. • The concordance of the models is an important component of the integration. • The measurement of the applicability domain improves the prediction. • The use of a

  9. PNW River Reach Files -- 1:100k Watercourses (arcs)

    Data.gov (United States)

    Pacific States Marine Fisheries Commission — This feature class includes the ARC features from the 2001 version of the PNW River Reach files Arc/INFO coverage. Separate, companion feature classes are also...

  10. PNW River Reach Files -- 1:100k Waterbodies (polygons)

    Data.gov (United States)

    Pacific States Marine Fisheries Commission — This feature class includes the POLYGON waterbody features from the 2001 version of the PNW River Reach files Arc/INFO coverage. Separate, companion feature classes...

  11. Stream Habitat Reach Summary - North Coast [ds63

    Data.gov (United States)

    California Natural Resource Agency — The shapefile is based on habitat unit level data summarized at the stream reach level. The database represents salmonid stream habitat surveys from 645 streams of...

  12. LTRM Fish Sampling Strata, UMRS La Grange Reach

    Data.gov (United States)

    Department of the Interior — The data set includes delineation of sampling strata for the six study reaches of the UMRR Program’s LTRM element. Separate strata coverages exist for each of the...

  13. LTRM Water Quality Sampling Strata, UMRS La Grange Reach

    Data.gov (United States)

    Department of the Interior — The data set includes delineation of sampling strata for the six study reaches of the UMRR Program’s LTRM element. Separate strata coverages exist for each of the...

  14. Decoding natural reach-and-grasp actions from human EEG

    Science.gov (United States)

    Schwarz, Andreas; Ofner, Patrick; Pereira, Joana; Ioana Sburlea, Andreea; Müller-Putz, Gernot R.

    2018-02-01

    Objective. Despite the high number of degrees of freedom of the human hand, most actions of daily life can be executed incorporating only palmar, pincer and lateral grasp. In this study we attempt to discriminate these three different executed reach-and-grasp actions utilizing their EEG neural correlates. Approach. In a cue-guided experiment, 15 healthy individuals were asked to perform these actions using daily life objects. We recorded 72 trials for each reach-and-grasp condition and from a no-movement condition. Main results. Using low-frequency time domain features from 0.3 to 3 Hz, we achieved binary classification accuracies of 72.4%, STD  ±  5.8% between grasp types, for grasps versus no-movement condition peak performances of 93.5%, STD  ±  4.6% could be reached. In an offline multiclass classification scenario which incorporated not only all reach-and-grasp actions but also the no-movement condition, the highest performance could be reached using a window of 1000 ms for feature extraction. Classification performance peaked at 65.9%, STD  ±  8.1%. Underlying neural correlates of the reach-and-grasp actions, investigated over the primary motor cortex, showed significant differences starting from approximately 800 ms to 1200 ms after the movement onset which is also the same time frame where classification performance reached its maximum. Significance. We could show that it is possible to discriminate three executed reach-and-grasp actions prominent in people’s everyday use from non-invasive EEG. Underlying neural correlates showed significant differences between all tested conditions. These findings will eventually contribute to our attempt of controlling a neuroprosthesis in a natural and intuitive way, which could ultimately benefit motor impaired end users in their daily life actions.

  15. REACH: next step to a sound chemicals management.

    Science.gov (United States)

    Van der Wielen, Arnold

    2007-12-01

    REACH is the new European Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals. It entered into force on 1st June 2007 to streamline and improve the former legislative framework on new and on existing chemical substances of the European Union. Companies which manufacture or import more than 1 tonne of a substance per year will be required to register the substance at the new EU Chemicals Agency located in Helsinki. REACH places greater responsibility on industry to manage the risks that chemicals may pose to the health and the environment and to provide safety information that will be passed down the supply chain. In principle, REACH applies to all chemicals as such, as components in preparations and as used in articles. REACH is a radical step forward in the EU chemicals management. The onus will move from the authorities to industry. In addition, REACH will allow the further evaluation of substances where there are grounds for concern, foresees an authorisation system for the use of substances of very high concern and a system of restrictions, where applicable, for substances of concern. The Authorisation system will require companies to switch progressively to safer alternatives where a suitable alternative exists. Current use restrictions will remain under REACH system.

  16. Expanding the reach of heavy neutrino searches at the LHC

    Directory of Open Access Journals (Sweden)

    Andrés Flórez

    2018-03-01

    Full Text Available The observation of neutrino oscillations establishes that neutrinos have non-zero mass and provides one of the more compelling arguments for physics beyond the standard model (SM of particle physics. We present a feasibility study to search for hypothetical Majorana neutrinos (N with TeV scale masses, predicted by extensions of the SM to explain the small but non-zero SM neutrino mass, using vector boson fusion (VBF processes at the 13 TeV LHC. In the context of the minimal Type-I seesaw mechanism (mTISM, the VBF production cross-section of a lepton (ℓ and associated heavy Majorana neutrino (Nℓ surpasses that of the Drell–Yan process at approximately mNℓ=1.4TeV. We consider second and third-generation heavy neutrino (Nμ or Nτ, where ℓ= muon (μ or tau (τ leptons production through VBF processes, with subsequent Nμ and Nτ decays to a lepton and two jets, as benchmark cases to show the effectiveness of the VBF topology for Nℓ searches at the 13 TeV LHC. The requirement of a dilepton pair combined with four jets, two of which are identified as VBF jets with large separation in pseudorapidity and a TeV scale dijet mass, is effective at reducing the SM background. These criteria may provide expected exclusion bounds, at 95% confidence level, of mNℓ<1.7 (2.4 TeV, assuming 100 (1000 fb−1 of 13 TeV data from the LHC and mixing |VℓNℓ|2=1. The use of the VBF topology to search for mNℓ increases the discovery reach at the LHC, with expected significances greater than 5σ (3σ for Nℓ masses up to 1.7 (2.05 TeV using 1000fb−1 of 13 TeV data from the LHC.

  17. Expanding the reach of heavy neutrino searches at the LHC

    Science.gov (United States)

    Flórez, Andrés; Gui, Kaiwen; Gurrola, Alfredo; Patiño, Carlos; Restrepo, Diego

    2018-03-01

    The observation of neutrino oscillations establishes that neutrinos have non-zero mass and provides one of the more compelling arguments for physics beyond the standard model (SM) of particle physics. We present a feasibility study to search for hypothetical Majorana neutrinos (N) with TeV scale masses, predicted by extensions of the SM to explain the small but non-zero SM neutrino mass, using vector boson fusion (VBF) processes at the 13 TeV LHC. In the context of the minimal Type-I seesaw mechanism (mTISM), the VBF production cross-section of a lepton (ℓ) and associated heavy Majorana neutrino (Nℓ) surpasses that of the Drell-Yan process at approximately mNℓ = 1.4TeV. We consider second and third-generation heavy neutrino (Nμ or Nτ, where ℓ= muon (μ) or tau (τ) leptons) production through VBF processes, with subsequent Nμ and Nτ decays to a lepton and two jets, as benchmark cases to show the effectiveness of the VBF topology for Nℓ searches at the 13 TeV LHC. The requirement of a dilepton pair combined with four jets, two of which are identified as VBF jets with large separation in pseudorapidity and a TeV scale dijet mass, is effective at reducing the SM background. These criteria may provide expected exclusion bounds, at 95% confidence level, of mNℓ < 1.7 (2.4) TeV, assuming 100 (1000) fb-1 of 13 TeV data from the LHC and mixing |VℓNℓ|2 = 1. The use of the VBF topology to search for mNℓ increases the discovery reach at the LHC, with expected significances greater than 5σ (3σ) for Nℓ masses up to 1.7 (2.05) TeV using 1000fb-1 of 13 TeV data from the LHC.

  18. The Role of Absorption Cooling for Reaching Sustainable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lindmark, Susanne

    2005-07-01

    This thesis focuses on the role and potential of absorption cooling in future energy systems. Two types of energy systems are investigated: a district energy system based on waste incineration and a distributed energy system with natural gas as fuel. In both cases, low temperature waste heat is used as driving energy for the absorption cooling. The main focus is to evaluate the absorption technology in an environmental perspective, in terms of reduced CO{sub 2} emissions. Economic evaluations are also performed. The reduced electricity when using absorption cooling instead of compression cooling is quantified and expressed as an increased net electrical yield. The results show that absorption cooling is an environmentally friendly way to produce cooling as it reduces the use of electrically driven cooling in the energy system and therefore also reduces global CO{sub 2} emissions. In the small-scale trigeneration system the electricity use is lowered with 84 % as compared to cooling production with compression chillers only. The CO{sub 2} emissions can be lowered to 45 CO{sub 2}/MWh{sub c} by using recoverable waste heat as driving heat for absorption chillers. However, the most cost effective cooling solution in a district energy system is a combination between absorption and compression cooling technologies according to the study. Absorption chillers have the potential to be suitable bottoming cycles for power production in distributed systems. Net electrical yields over 55 % may be reached in some cases with gas motors and absorption chillers. This small-scale system for cogeneration of power and cooling shows electrical efficiencies comparable to large-scale power plants and may contribute to reducing peak electricity demand associated with the cooling demand.

  19. Solid expandable systems put deepwater targets within reach

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Roca, Eduardo [Enventure Global Technology L.L.C., Houston, TX (United States). Latin America; Fristch, Jerry [Enventure Global Technology L.L.C., Houston, TX (United States)

    2008-07-01

    Enabling technologies that take drilling operations to deeper objectives have made a significant impact on the practicality of many projects, especially deep water offshore targets. Increasing vertical depth and lateral reach requires adequate hole size to attain the desired objectives of the well bore. Solid expandable technology can maintain and retain hole size to address both the physical limitations and the economic feasibility of deep water operations. With each and every casing point, the potential for adequate hole size at total depth (TD) decreases. Solid expandable open hole liners and single-diameter systems reduce and eliminate, respectively, the well bore tapering that dictates hole size at TD and subsequent completion size. Successful mitigation of this tapering, whether through the entire well bore or through select zones, enables operators to gain access to previously unreachable reserves. Solid expandable systems have proven to be reliable and effective with over 1,000 installations in a myriad of conditions and environments worldwide. To date, over 115 of those applications have been in deep water environments. The current operating envelope for solid expandable systems include the deepest installation at {approx}28,750 ft (8,763 m) and the longest at 6,867 ft (2,083 m) in water depth over 3,150 ft (960 m). This record-length application consisted of an open hole liner installed and expanded in a single run. This paper will discuss the effectiveness of solid expandable systems in deep water operations and how the technology brings value to offshore projects especially when planned into the initial design. Case histories will be used to further illustrate the features, advantages, and benefits of expandable technology. In addition, this paper will examine the state of the solid expandable technology and its continuing evolution to provide even more drilling solutions. (author)

  20. Impulsivity modulates performance under response uncertainty in a reaching task.

    Science.gov (United States)

    Tzagarakis, C; Pellizzer, G; Rogers, R D

    2013-03-01

    We sought to explore the interaction of the impulsivity trait with response uncertainty. To this end, we used a reaching task (Pellizzer and Hedges in Exp Brain Res 150:276-289, 2003) where a motor response direction was cued at different levels of uncertainty (1 cue, i.e., no uncertainty, 2 cues or 3 cues). Data from 95 healthy adults (54 F, 41 M) were analysed. Impulsivity was measured using the Barratt Impulsiveness Scale version 11 (BIS-11). Behavioral variables recorded were reaction time (RT), errors of commission (referred to as 'early errors') and errors of precision. Data analysis employed generalised linear mixed models and generalised additive mixed models. For the early errors, there was an interaction of impulsivity with uncertainty and gender, with increased errors for high impulsivity in the one-cue condition for women and the three-cue condition for men. There was no effect of impulsivity on precision errors or RT. However, the analysis of the effect of RT and impulsivity on precision errors showed a different pattern for high versus low impulsives in the high uncertainty (3 cue) condition. In addition, there was a significant early error speed-accuracy trade-off for women, primarily in low uncertainty and a 'reverse' speed-accuracy trade-off for men in high uncertainty. These results extend those of past studies of impulsivity which help define it as a behavioural trait that modulates speed versus accuracy response styles depending on environmental constraints and highlight once more the importance of gender in the interplay of personality and behaviour.

  1. Memory-guided reaching in a patient with visual hemiagnosia.

    Science.gov (United States)

    Cornelsen, Sonja; Rennig, Johannes; Himmelbach, Marc

    2016-06-01

    The two-visual-systems hypothesis (TVSH) postulates that memory-guided movements rely on intact functions of the ventral stream. Its particular importance for memory-guided actions was initially inferred from behavioral dissociations in the well-known patient DF. Despite of rather accurate reaching and grasping movements to visible targets, she demonstrated grossly impaired memory-guided grasping as much as impaired memory-guided reaching. These dissociations were later complemented by apparently reversed dissociations in patients with dorsal damage and optic ataxia. However, grasping studies in DF and optic ataxia patients differed with respect to the retinotopic position of target objects, questioning the interpretation of the respective findings as a double dissociation. In contrast, the findings for reaching errors in both types of patients came from similar peripheral target presentations. However, new data on brain structural changes and visuomotor deficits in DF also questioned the validity of a double dissociation in reaching. A severe visuospatial short-term memory deficit in DF further questioned the specificity of her memory-guided reaching deficit. Therefore, we compared movement accuracy in visually-guided and memory-guided reaching in a new patient who suffered a confined unilateral damage to the ventral visual system due to stroke. Our results indeed support previous descriptions of memory-guided movements' inaccuracies in DF. Furthermore, our data suggest that recently discovered optic-ataxia like misreaching in DF is most likely caused by her parieto-occipital and not by her ventral stream damage. Finally, multiple visuospatial memory measurements in HWS suggest that inaccuracies in memory-guided reaching tasks in patients with ventral damage cannot be explained by visuospatial short-term memory or perceptual deficits, but by a specific deficit in visuomotor processing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. [The REACH legislation: the consumer and environment protection perspective].

    Science.gov (United States)

    Gundert-Remy, Ursula

    2008-12-01

    REACH has been initiated with the aim of improving existing legislation. In order to assist in the interpretation of the REACH legislation, guidance documents have been developed, which have only lately become available. According to the REACH annexes and supported by guidance documents, waiving of test requirements will be possible, thus, opening the possibility that under REACH no new (eco)toxicological data will be required. Concerning products, a guidance document was released in April 2008 stating that the substance concentration threshold of 0.1 % (w/w) applies to the article as produced or imported and it does not relate to the homogeneous materials or parts of an article, but relates to the article as such (i.e., as produced or imported). Hence, notification will not be required for many products containing chemicals with properties which place them on the candidate list for authorization. In summary, it is at present not foreseeable whether the expected benefit of the REACH legislation will materialise for the environment and for the health of consumers and at the work place.

  3. Switching from reaching to navigation: differential cognitive strategies for spatial memory in children and adults.

    Science.gov (United States)

    Belmonti, Vittorio; Cioni, Giovanni; Berthoz, Alain

    2015-07-01

    Navigational and reaching spaces are known to involve different cognitive strategies and brain networks, whose development in humans is still debated. In fact, high-level spatial processing, including allocentric location encoding, is already available to very young children, but navigational strategies are not mature until late childhood. The Magic Carpet (MC) is a new electronic device translating the traditional Corsi Block-tapping Test (CBT) to navigational space. In this study, the MC and the CBT were used to assess spatial memory for navigation and for reaching, respectively. Our hypothesis was that school-age children would not treat MC stimuli as navigational paths, assimilating them to reaching sequences. Ninety-one healthy children aged 6 to 11 years and 18 adults were enrolled. Overall short-term memory performance (span) on both tests, effects of sequence geometry, and error patterns according to a new classification were studied. Span increased with age on both tests, but relatively more in navigational than in reaching space, particularly in males. Sequence geometry specifically influenced navigation, not reaching. The number of body rotations along the path affected MC performance in children more than in adults, and in women more than in men. Error patterns indicated that navigational sequences were increasingly retained as global paths across development, in contrast to separately stored reaching locations. A sequence of spatial locations can be coded as a navigational path only if a cognitive switch from a reaching mode to a navigation mode occurs. This implies the integration of egocentric and allocentric reference frames, of visual and idiothetic cues, and access to long-term memory. This switch is not yet fulfilled at school age due to immature executive functions. © 2014 John Wiley & Sons Ltd.

  4. Early Life Conditions and Physiological Stress following the Transition to Farming in Central/Southeast Europe: Skeletal Growth Impairment and 6000 Years of Gradual Recovery.

    Directory of Open Access Journals (Sweden)

    Alison A Macintosh

    Full Text Available Early life conditions play an important role in determining adult body size. In particular, childhood malnutrition and disease can elicit growth delays and affect adult body size if severe or prolonged enough. In the earliest stages of farming, skeletal growth impairment and small adult body size are often documented relative to hunter-gatherer groups, though this pattern is regionally variable. In Central/Southeast Europe, it is unclear how early life stress, growth history, and adult body size were impacted by the introduction of agriculture and ensuing long-term demographic, social, and behavioral change. The current study assesses this impact through the reconstruction and analysis of mean stature, body mass, limb proportion indices, and sexual dimorphism among 407 skeletally mature men and women from foraging and farming populations spanning the Late Mesolithic through Early Medieval periods in Central/Southeast Europe (~7100 calBC to 850 AD. Results document significantly reduced mean stature, body mass, and crural index in Neolithic agriculturalists relative both to Late Mesolithic hunter-gatherer-fishers and to later farming populations. This indication of relative growth impairment in the Neolithic, particularly among women, is supported by existing evidence of high developmental stress, intensive physical activity, and variable access to animal protein in these early agricultural populations. Among subsequent agriculturalists, temporal increases in mean stature, body mass, and crural index were more pronounced among Central European women, driving declines in the magnitude of sexual dimorphism through time. Overall, results suggest that the transition to agriculture in Central/Southeast Europe was challenging for early farming populations, but was followed by gradual amelioration across thousands of years, particularly among Central European women. This sex difference may be indicative, in part, of greater temporal variation in the

  5. Early Life Conditions and Physiological Stress following the Transition to Farming in Central/Southeast Europe: Skeletal Growth Impairment and 6000 Years of Gradual Recovery

    Science.gov (United States)

    Macintosh, Alison A.; Pinhasi, Ron; Stock, Jay T.

    2016-01-01

    Early life conditions play an important role in determining adult body size. In particular, childhood malnutrition and disease can elicit growth delays and affect adult body size if severe or prolonged enough. In the earliest stages of farming, skeletal growth impairment and small adult body size are often documented relative to hunter-gatherer groups, though this pattern is regionally variable. In Central/Southeast Europe, it is unclear how early life stress, growth history, and adult body size were impacted by the introduction of agriculture and ensuing long-term demographic, social, and behavioral change. The current study assesses this impact through the reconstruction and analysis of mean stature, body mass, limb proportion indices, and sexual dimorphism among 407 skeletally mature men and women from foraging and farming populations spanning the Late Mesolithic through Early Medieval periods in Central/Southeast Europe (~7100 calBC to 850 AD). Results document significantly reduced mean stature, body mass, and crural index in Neolithic agriculturalists relative both to Late Mesolithic hunter-gatherer-fishers and to later farming populations. This indication of relative growth impairment in the Neolithic, particularly among women, is supported by existing evidence of high developmental stress, intensive physical activity, and variable access to animal protein in these early agricultural populations. Among subsequent agriculturalists, temporal increases in mean stature, body mass, and crural index were more pronounced among Central European women, driving declines in the magnitude of sexual dimorphism through time. Overall, results suggest that the transition to agriculture in Central/Southeast Europe was challenging for early farming populations, but was followed by gradual amelioration across thousands of years, particularly among Central European women. This sex difference may be indicative, in part, of greater temporal variation in the social status afforded

  6. East European “BigBang” Revisiting East Asia? – Why Chinese “Gradual Transition” Can End Up with “Shock Therapy”

    Directory of Open Access Journals (Sweden)

    Mikhail Karpov

    2018-04-01

    Full Text Available Polish and Russian “shock therapy” policies in 1990 and 1992 respectively were in fact forced deregulation packages aimed at preventing total macroeconomic and institutional collapse. Some important features of these packages were contrary to neo-classical prescriptions, since the “shock therapists” operated in unprecedented setting of imploding “command economy”. This setting as such never was a subject of neo-liberal theoreticians before it became empirical reality. Marxist-Leninist single party-state regimes are prone to macroeconomic implosion, since the socio-economic actors they create during forced “transition to market” prefer neither “plan” nor “market”, but a grey “no-man’s land” between the two. This position allows them to “privatize the profits” and to “nationalize the costs”, contributing to accumulation of tremendous macroeconomic imbalances on the aggregate systemic level. It also creates socio-economic, political and institutional impasse of financial deleveraging, which may eventually turn into a forced “big-bang” package amidst systemic implosion. Chinese “gradual transition” – with all singularities – still fits quite well into this dynamic empirical pattern. Sharp decline in the Chinese growth rate since spring 201 3 was a man-made phenomenon. The leadership intends to deregulate interest rates and upgrade financial discipline of scared investors, making them to withdraw money from the state and non-state assets. The overall systemic setting increases the chances of financial deleveraging in China to turn eventually into a forced “big-bang” upheaval.

  7. Feedback and feedforward adaptation to visuomotor delay during reaching and slicing movements.

    Science.gov (United States)

    Botzer, Lior; Karniel, Amir

    2013-07-01

    It has been suggested that the brain and in particular the cerebellum and motor cortex adapt to represent the environment during reaching movements under various visuomotor perturbations. It is well known that significant delay is present in neural conductance and processing; however, the possible representation of delay and adaptation to delayed visual feedback has been largely overlooked. Here we investigated the control of reaching movements in human subjects during an imposed visuomotor delay in a virtual reality environment. In the first experiment, when visual feedback was unexpectedly delayed, the hand movement overshot the end-point target, indicating a vision-based feedback control. Over the ensuing trials, movements gradually adapted and became accurate. When the delay was removed unexpectedly, movements systematically undershot the target, demonstrating that adaptation occurred within the vision-based feedback control mechanism. In a second experiment designed to broaden our understanding of the underlying mechanisms, we revealed similar after-effects for rhythmic reversal (out-and-back) movements. We present a computational model accounting for these results based on two adapted forward models, each tuned for a specific modality delay (proprioception or vision), and a third feedforward controller. The computational model, along with the experimental results, refutes delay representation in a pure forward vision-based predictor and suggests that adaptation occurred in the forward vision-based predictor, and concurrently in the state-based feedforward controller. Understanding how the brain compensates for conductance and processing delays is essential for understanding certain impairments concerning these neural delays as well as for the development of brain-machine interfaces. © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  8. Integration of QSAR models for bioconcentration suitable for REACH

    Energy Technology Data Exchange (ETDEWEB)

    Gissi, Andrea [Laboratory of Chemistry and Environmental Toxicology, IRCCS - Istituto di Ricerche Farmacologiche “Mario Negri”, via Giuseppe La Masa 19, 20156 Milan (Italy); Dipartimento di Farmacia — Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, via Orabona 4, I-70125 Bari (Italy); Nicolotti, Orazio; Carotti, Angelo; Gadaleta, Domenico [Dipartimento di Farmacia — Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, via Orabona 4, I-70125 Bari (Italy); Lombardo, Anna [Laboratory of Chemistry and Environmental Toxicology, IRCCS - Istituto di Ricerche Farmacologiche “Mario Negri”, via Giuseppe La Masa 19, 20156 Milan (Italy); Benfenati, Emilio, E-mail: benfenati@marionegri.it [Laboratory of Chemistry and Environmental Toxicology, IRCCS - Istituto di Ricerche Farmacologiche “Mario Negri”, via Giuseppe La Masa 19, 20156 Milan (Italy)

    2013-07-01

    QSAR (Quantitative Structure Activity Relationship) models can be a valuable alternative method to replace or reduce animal test required by REACH. In particular, some endpoints such as bioconcentration factor (BCF) are easier to predict and many useful models have been already developed. In this paper we describe how to integrate two popular BCF models to obtain more reliable predictions. In particular, the herein presented integrated model relies on the predictions of two among the most used BCF models (CAESAR and Meylan), together with the Applicability Domain Index (ADI) provided by the software VEGA. Using a set of simple rules, the integrated model selects the most reliable and conservative predictions and discards possible outliers. In this way, for the prediction of the 851 compounds included in the ANTARES BCF dataset, the integrated model discloses a R{sup 2} (coefficient of determination) of 0.80, a RMSE (Root Mean Square Error) of 0.61 log units and a sensitivity of 76%, with a considerable improvement in respect to the CAESAR (R{sup 2} = 0.63; RMSE = 0.84 log units; sensitivity 55%) and Meylan (R{sup 2} = 0.66; RMSE = 0.77 log units; sensitivity 65%) without discarding too many predictions (118 out of 851). Importantly, considering solely the compounds within the new integrated ADI, the R{sup 2} increased to 0.92, and the sensitivity to 85%, with a RMSE of 0.44 log units. Finally, the use of properly set safety thresholds applied for monitoring the so called “suspicious” compounds, which are those chemicals predicted in proximity of the border normally accepted to discern non-bioaccumulative from bioaccumulative substances, permitted to obtain an integrated model with sensitivity equal to 100%. - Highlights: • Applying two independent QSAR models for bioconcentration factor increases the prediction. • The concordance of the models is an important component of the integration. • The measurement of the applicability domain improves the

  9. REACH-related substitution within the Danish printing industry

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Bøg, Carsten; Markussen, Helene

    are running a substitution project. A major part of the work has been mapping the presence of chemicals which are potential candidates for substitution (e.g. PBT, CMR, vPvB, EDS) within the Danish printing industry. The mapping comprises a combination of a literature study and an investigation of the actual......The accomplishment of the EU REACH regulation will most probably promote substitution within sectors handling a lot of different chemicals like the printing industry. With the aim of being at the cutting edge of this development the Danish EPA together with the Danish printing industry and IPU...... fulfil one or more of the criteria (e.g. CMR, EDS) for the REACH Annex XIV candidate list (authorisation). The paper presents the results of the mapping of chemical candidates and the first results of the actual substitutions. Keywords: REACH, chemicals, substitution, printing industry....

  10. Reach-scale stream restoration in agricultural streams of southern Minnesota alters structural and functional responses of macroinvertebrates

    Science.gov (United States)

    Dolph, Christine L.; Eggert, Susan L.; Magner, Joe; Ferrington, Leonard C.; Vondracek, Bruce C.

    2015-01-01

    Recent studies suggest that stream restoration at the reach scale may not increase stream biodiversity, raising concerns about the utility of this conservation practice. We examined whether reach-scale restoration in disturbed agricultural streams was associated with changes in macroinvertebrate community structure (total macroinvertebrate taxon richness, total macroinvertebrate density, Ephemeroptera, Plecoptera, Trichoptera [EPT] taxon richness, % abundance of EPT taxa) or secondary production (macroinvertebrate biomass over time). We collected macroinvertebrate samples over the course of 1 y from restored and unrestored reaches of 3 streams in southern Minnesota and used generalized least-square (GLS) models to assess whether measures of community structure were related to reach type, stream site, or sampling month. After accounting for effects of stream site and time, we found no significant difference in total taxon richness or % abundance of EPT taxa between restored and unrestored reaches. However, the number of EPT taxa and macroinvertebrate density were significantly higher in restored than in unrestored reaches. We compared secondary production estimates among study reaches based on 95th-percentile confidence intervals generated via bootstrapping. In each study stream, secondary production was significantly (2–3×) higher in the restored than in the unrestored reach. Higher productivity in the restored reaches was largely a result of the disproportionate success of a few dominant, tolerant taxa. Our findings suggest that reach-scale restoration may have ecological effects that are not detected by measures of total taxon richness alone.

  11. Composite Coiled Tubing for Extended Reach in Horizontal Oil Wells

    DEFF Research Database (Denmark)

    Costache, Andrei; Berggreen, Christian

    2017-01-01

    Conventional steel coiled tubing cannot reach along the entire length of very long horizontal oil wells. A lighter and more buoyant coiled tube is made possible using composite materials. The high stiffness to weight ratio of fiber reinforced polymers, coupled with a lower coefficient of friction......, has the potential of greatly extending the reach in horizontal oil wells. This study shows how to design composite coiled tubing and gives a comprehensive discussion about the most influential parameters. Several solutions, using glass-fiber and carbon are considered. Finite element models are used...

  12. Telerobotic operation of structurally flexible, long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.; Hwang, D.H.; Babcock, S.M.

    1994-01-01

    As a part of the Department of Energy's Environmental Restoration and Waste Management Program, long-reach manipulators are being considered for the retrieval of waste from large storage tanks. Long-reach manipulators may have characteristics significantly different from those of typical industrial robots because of the flexibility of long links needed to cover the large workspace. To avoid structural vibrations during operation, control algorithms employing various types of shaping filters were investigated. A new approach that uses embedded simulation was developed and compared with others. In the new approach, generation of joint trajectories considering link flexibility was also investigated

  13. Parents' perception about their preterm child's social interaction reaching school age

    NARCIS (Netherlands)

    Laansma, Frederike; Smidt, Eva; Crajé, Céline; Luinge, Margreet

    2017-01-01

    A key element in social development is interaction with others. Preterm infants have an increased risk for problems in this aspect. We aimed to gain insight into parents’ perception about their preterm child’s social interaction upon reaching school age. Twelve caregivers of preterm infants aged

  14. Survey studies how to reach primary hardwood producers with new information

    Science.gov (United States)

    Philip Araman; Robert Smith; Matthew Winn

    2009-01-01

    It is important for the timber industry to obtain new knowledge in order to stay competitive, increase productivity, or to produce new products from a sometime changing resource. We sought to understand how new knowledge— innovative techniques, improved technology, and marketing information—reach our primary forest industries in the United States. We surveyed hardwood...

  15. Methadone Detoxification Versus Traditional Gradual Decrease in the Consumed Amount of Refined Opium Dross (Shireh: The Preferred Method for Controlling Withdrawal Syndrome

    Directory of Open Access Journals (Sweden)

    Mohammadreza Farsinejad

    2012-08-01

    Full Text Available Background: The aim of this study was to compare the effectiveness of methadone detoxification with traditional method of gradual decrement in the abused amount of the refined opium dross (Shireh to control withdrawal syndrome in Shireh-addicted patients. Methods: In this study, two groups of Shireh addicts were compared. The first group was treated by methadone and the second group by gradual decrement in the amount of consumed Shireh. Those experiencing the adverse effects of the treatment were excluded from the study. Methadone dose was calculated based on the amount of the Shireh consumed and detoxification was performed during a 21-day period. In the second group, the amount of the consumed Shireh was gradually decreased within 21 days and some of the withdrawal symptoms were selected as indicators for patient evaluation. Results: A total of 35 patients (16 versus 19 patients in the first and second groups were evaluated. Their mean age was 43 ± 4 years and all were male. A statistically significant difference was found between these two groups in terms of severity and duration of withdrawal symptoms within the first five days and their duration after the 21st day of the onset of detoxification (P< 0.05. Conclusion: In comparison with methadone detoxification, traditional method of gradually decreasing the consumed amount of Shireh controls the severity and duration of withdrawal symptoms better in the course of detoxification.

  16. Factors associated with reaching or not reaching target HbA1c after initiation of basal or premixed insulin in patients with type 2 diabetes.

    Science.gov (United States)

    Scheen, A J; Schmitt, H; Jiang, H H; Ivanyi, T

    2017-02-01

    To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA 1c ) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insulin regimen in patients with type 2 diabetes. This post-hoc analysis of insulin-naïve patients in the DURABLE study randomised to receive either insulin glargine or insulin lispro mix 25 evaluated the percentages of patients achieving a target HbA 1c of <7.0% (<53mmol/mol) per baseline HbA 1c quartiles, and the effect of each insulin regimen on the relative contributions of PHG and FHG to overall hyperglycaemia. Patients had comparable demographic characteristics and similar HbA 1c and FHG values at baseline in each HbA 1c quartile regardless of whether they reached the target HbA 1c . The higher the HbA 1c quartile, the greater was the decrease in HbA 1c , but also the smaller the percentage of patients achieving the target HbA 1c . HbA 1c and FHG decreased more in patients reaching the target, resulting in significantly lower values at endpoint in all baseline HbA 1c quartiles with either insulin treatment. Patients not achieving the target HbA 1c had slightly higher insulin doses, but lower total hypoglycaemia rates. Smaller decreases in FHG were associated with not reaching the target HbA 1c , suggesting a need to increase basal or premixed insulin doses to achieve targeted fasting plasma glucose and improve patient response before introducing more intensive prandial insulin regimens. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  17. Task-dependent vestibular feedback responses in reaching

    NARCIS (Netherlands)

    Keyser, J.; Medendorp, W.P.; Selen, L.P.J.

    2017-01-01

    When reaching for an earth-fixed object during self-rotation, the motor system should appropriately integrate vestibular signals and sensory predictions to compensate for the intervening motion and its induced inertial forces. While it is well established that this integration occurs rapidly, it is

  18. Reaching the Unreached - Special Emphasis on the Communication ...

    African Journals Online (AJOL)

    This paper provides an overview of the existing communication component in the Expanded Program on Immunisation (EPI) training in Zambia and critically analyses the need for a humane touch in the communication process so as to reach the target audience effectively. Interpersonal Communication (IPC) in Zambia has ...

  19. Shaping of Reach-to-Grasp Kinematics by Intentions

    DEFF Research Database (Denmark)

    Egmose, Ida; Køppe, Simo

    2017-01-01

    is primarily associated with transporting the hand to the object (i.e., extrinsic object properties), the decelerating part of the reach is used as a preparation for object manipulation (i.e., prepare the grasp or the subsequent action), and the grasp is associated with manipulating the object's intrinsic...

  20. Recognition for reaching the most vulnerable populations in Burkina ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Recognition for reaching the most vulnerable populations in Burkina Faso. 07 novembre 2016. An IDRC supported project was recognized for its efforts to improve health service provision and the monitoring of pregnant women, new mothers, children, and people living with HIV in Burkina Faso's Nouna district. Dr Maurice ...

  1. Object Permanence, Reaching, and Locomotion in Infants Who Are Blind.

    Science.gov (United States)

    Ross, S.; Tobin, M. J.

    1997-01-01

    The literature on the effects of congenital blindness on infants' development of motor functions and concepts of object permanence is reviewed. The article questions the idea that infants must first develop an object concept before sound clues alone will elicit reaching. Possible interventions to redress the effects of congenital blindness on…

  2. Reaching an understanding innovations in how we view reading assessment

    CERN Document Server

    Sabatini, John; O'Reilly, Tenaha

    2012-01-01

    Reaching an Understanding: Innovations in How We View Reading Assessment builds upon the editors previous book Measuring Up: Advances in How We Assess Reading Ability by representing some early attempts to apply theory to help guide the development of new assessments and measurement models.

  3. Nanshan Aluminum Reached Strategic Cooperation with CSR Corporation Limited

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    As a key supplier of aluminum profiles and aluminum plate,sheet and trip products for CSR Corporation Limited,Nanshan Aluminum will join hands with CSR Corporation Limited to reach strategic cooperation.On January 5,Nanshan Aluminum signed strategic cooperation agreement with CSR Sifang Locomotive&Rolling; Stock Co.,Ltd,both

  4. An Assessment of EU 2020 Strategy: Too Far to Reach?

    Science.gov (United States)

    Colak, Mehmet Selman; Ege, Aylin

    2013-01-01

    In 2010, EU adopted a new growth strategy which includes three growth priorities and five headline targets to be reached by 2020. The aim of this paper is to investigate the current performance of the EU member and candidate states in achieving these growth priorities and the overall strategy target by allocating the headline targets into the…

  5. Development of postural adjustments during reaching in infants with CP

    NARCIS (Netherlands)

    Hadders-Algra, M; van der Fits, IBM; Stremmelaar, EF; Touwen, BCL

    1999-01-01

    The development of postural adjustments during reaching movements was longitudinally studied in seven infants with cerebral palsy (CP) between 4 and 18 months of age. Five infants developed spastic hemiplegia, one spastic tetraplegia, and one spastic tetraplegia with athetosis. Each assessment

  6. Evaluation of the Implementation of the Reaching Every District ...

    African Journals Online (AJOL)

    46987.2

    ABSTRACT. Background: In 2003, the Government of Zambia in collaboration with implementing partners in immunisation introduced the Reaching Every District. (RED) strategy to improve immunization coverage. The aim of this study is to evaluate the implementation of the. RED strategy in Lusaka district. Methods: A ...

  7. Reach for the Stars: Visions for Literacy Coaching Programs

    Science.gov (United States)

    DeFord, Diane

    2012-01-01

    This brief by the Literacy Coaching Clearinghouse is about reaching for the stars--stories of vision and commitment from educators in small and large schools. Everyone knows of people who are held up as "visionaries" throughout history: Leonardo Da Vinci, Mahatma Gandhi, Jules Verne, Thomas Edison, Susan Anthony, or John Dewey, to name a few. The…

  8. Advanced reach tool (ART) : Development of the mechanistic model

    NARCIS (Netherlands)

    Fransman, W.; Tongeren, M. van; Cherrie, J.W.; Tischer, M.; Schneider, T.; Schinkel, J.; Kromhout, H.; Warren, N.; Goede, H.; Tielemans, E.

    2011-01-01

    This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe.

  9. Reaching the Summit: Deaf Adults as Essential Partners in Education

    Science.gov (United States)

    Bourne-Firl, Bridgetta

    2016-01-01

    How do we reach the summit in terms of supporting the best transition possible for each young deaf or hard of hearing individual in the United States? Should professionals who are hearing work alone to succeed with deaf and hard of hearing students? No matter how good the intention, if we want deaf and hard of hearing students to transition from…

  10. Reaching the Millennium Development Goals : Mauritania Should Care

    OpenAIRE

    Magnoli Bocchi, Alessandro; Pontara, Nicola; Fall, Khayar; Tejada, Catalina M.; Gallego Cuervo, Pablo

    2008-01-01

    Mauritania is a resource-rich developing country. As many other African nations, it will not reach most of the Millennium Development Goals, unless the authorities commit to accelerating progress. To succeed by 2015, the government needs to: mobilize additional financial resources, introduce policy changes at the sector level, and strengthen the links between strategic objectives and the b...

  11. Patterns of arm muscle activation involved in octopus reaching movements.

    Science.gov (United States)

    Gutfreund, Y; Flash, T; Fiorito, G; Hochner, B

    1998-08-01

    The extreme flexibility of the octopus arm allows it to perform many different movements, yet octopuses reach toward a target in a stereotyped manner using a basic invariant motor structure: a bend traveling from the base of the arm toward the tip (Gutfreund et al., 1996a). To study the neuronal control of these movements, arm muscle activation [electromyogram (EMG)] was measured together with the kinematics of reaching movements. The traveling bend is associated with a propagating wave of muscle activation, with maximal muscle activation slightly preceding the traveling bend. Tonic activation was occasionally maintained afterward. Correlation of the EMG signals with the kinematic variables (velocities and accelerations) reveals that a significant part of the kinematic variability can be explained by the level of muscle activation. Furthermore, the EMG level measured during the initial stages of movement predicts the peak velocity attained toward the end of the reaching movement. These results suggest that feed-forward motor commands play an important role in the control of movement velocity and that simple adjustment of the excitation levels at the initial stages of the movement can set the velocity profile of the whole movement. A simple model of octopus arm extension is proposed in which the driving force is set initially and is then decreased in proportion to arm diameter at the bend. The model qualitatively reproduces the typical velocity profiles of octopus reaching movements, suggesting a simple control mechanism for bend propagation in the octopus arm.

  12. How infants' reaches reveal principles of sensorimotor decision making

    Science.gov (United States)

    Dineva, Evelina; Schöner, Gregor

    2018-01-01

    In Piaget's classical A-not-B-task, infants repeatedly make a sensorimotor decision to reach to one of two cued targets. Perseverative errors are induced by switching the cue from A to B, while spontaneous errors are unsolicited reaches to B when only A is cued. We argue that theoretical accounts of sensorimotor decision-making fail to address how motor decisions leave a memory trace that may impact future sensorimotor decisions. Instead, in extant neural models, perseveration is caused solely by the history of stimulation. We present a neural dynamic model of sensorimotor decision-making within the framework of Dynamic Field Theory, in which a dynamic instability amplifies fluctuations in neural activation into macroscopic, stable neural activation states that leave memory traces. The model predicts perseveration, but also a tendency to repeat spontaneous errors. To test the account, we pool data from several A-not-B experiments. A conditional probabilities analysis accounts quantitatively how motor decisions depend on the history of reaching. The results provide evidence for the interdependence among subsequent reaching decisions that is explained by the model, showing that by amplifying small differences in activation and affecting learning, decisions have consequences beyond the individual behavioural act.

  13. Advanced REACH tool: A Bayesian model for occupational exposure assessment

    NARCIS (Netherlands)

    McNally, K.; Warren, N.; Fransman, W.; Entink, R.K.; Schinkel, J.; Van Tongeren, M.; Cherrie, J.W.; Kromhout, H.; Schneider, T.; Tielemans, E.

    2014-01-01

    This paper describes a Bayesian model for the assessment of inhalation exposures in an occupational setting; the methodology underpins a freely available web-based application for exposure assessment, the Advanced REACH Tool (ART). The ART is a higher tier exposure tool that combines disparate

  14. On stiffening cables of a long reach manipulator

    International Nuclear Information System (INIS)

    Wang, S.L.; Santiago, P.

    1996-01-01

    A long reach manipulator will be used for waste remediation in large underground storage tanks. The manipulator's slenderness makes it flexible and difficult to control. A low-cost and effective method to enhance the manipulator's stiffness is proposed in this research by using suspension cables. These cables can also be used to accurately measure the position of the manipulator's wrist

  15. Challenges of extension workers in reaching rural women farmers in ...

    African Journals Online (AJOL)

    The study examined the challenges of extension workers in reaching rural women farmers in Enugu State Nigeria. Questionnaire was used to collect data from a sample size of 52 extension workers. Data were analyzed using percentage, mean statistic, chart and factor analysis. Results revealed that training and visit ...

  16. Quality, Reach, and Impact of Open Scholarly Publishing in Latin ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Quality, Reach, and Impact of Open Scholarly Publishing in Latin America. Better understanding Open Access of scholarly research will help determine how it contributes to the greater circulation of knowledge and disseminating research in Latin America. Open Access (defined as unrestricted access to articles published in ...

  17. The Internet and the Global Reach of EU law

    DEFF Research Database (Denmark)

    Kuner, Christopher Barth

    and learning; international negotiation; coercion and conditionality; and blocking recognition of third country legal measures. The EU’s actions in exercising its global reach implicate important normative issues, such as distinguishing between the furtherance of core EU legal values and the advancement...

  18. Economic interpretation of environmental flow regime downstream diverted river reaches.

    Science.gov (United States)

    Gorla, Lorenzo; Perona, Paolo

    2013-04-01

    Water demand for hydropower production is increasing together with the consciousness of the importance of riparian ecosystems and biodiversity. Some Cantons in Switzerland and other alpine regions in Austria and in Sud Tirol (Italy) started replacing the inadequate concept of Minimum Flow Requirement (MFR) with a dynamic one, by releasing a fix percentage of the total inflow (e.g. 25 %) to the environment. In the same direction Perona et al. (in revision) mathematically formulated a method particularly suitable for small hydropower plants, handling the environment as a non-traditional water use, which competes with exploitators. This model uses the Principle of Equal Marginal Utility (PEMU) as optimal water allocation rule for generating like-natural flow releases while maximizing the aggregate economic benefit of all uses (Gorla and Perona, in revision). In this paper we show how redistribution policies can be interpreted in terms of PEMU, particularly we focus at traditional water repartition rules, such as the MFR, but also to dynamic ones like proportional redistribution. For the first case we show both ecological and economical arguments suggesting its inappropriateness; in the second case we highlight explicit points of strength and weakness, and suggest ways of improvement. For example the flow release allocation rule can be changed from inflow-independent ones (e.g., proportional redistribution), to inflow-dependent ones (e.g., non-proportional). The latters, having fewer constraints, can generally lead to better both ecological and economical performances. A class of simple functions, based on the PEMU, is then proposed as a suitable solution in run-of-river or small hydropower plants. Each water repartition policy underlies an ecosystem monetization. We explicit the value of the ecosystem health underlying each policy by means of the PEMU under a few assumptions, and discuss how the theoretic efficient redistribution law obtained by our approach is

  19. Ability to Reach Orgasm in Patients With Prostate Cancer Treated With Robot-assisted Laparoscopic Prostatectomy.

    Science.gov (United States)

    Østby-Deglum, Marie; Axcrona, Karol; Brennhovd, Bjørn; Dahl, Alv A

    2016-06-01

    To study the ability to reach orgasm after robot-assisted laparoscopic prostatectomy (RALP) in relation to demographic, cancer-related, and surgical variables, and the use of erectile aids. In this cross-sectional study at a mean of 3 years after RALP at Oslo University Hospital, 982 men were invited to complete a mailed questionnaire, and 777 responded. Respondents who reported postoperative radiotherapy or hormone treatment, or did not report on orgasm were omitted, leaving 609 patients for analysis. Ability to reach orgasm was rated on 1 question from The Expanded Prostate Cancer Index Composite 26-item version, and dichotomized into "good" or "poor." Overall, 27% of the men reported good ability to reach orgasm: 22% among those did not use erectile aids and 34% among those did (P = .001). Univariate analysis of men with good versus poor ability to reach orgasm showed many significant differences. In multivariate analysis, being older, having a reduced physical quality of life, and erectile dysfunction were significantly associated with poor ability to reach orgasm. Erectile dysfunction showed an odds ratio of 4.86 for poor orgasmic ability. The 48% of men who used erectile aids had significantly better orgasmic ability than the nonusers. In our sample, 27% had good ability to reach orgasm at a mean of 3 years after RALP. Poor orgasmic ability was associated with being older, poor erectile function, and a reduced physical quality of life. Using erectile aids increased the rate of good ability to reach orgasm. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. REACH: an effective catalyst for scaling up priority nutrition interventions at the country level.

    Science.gov (United States)

    Pearson, Brenda L; Ljungqvist, Björn

    2011-06-01

    Renewed Efforts Against Child Hunger (REACH) is the joint United Nations initiative to address Millennium Development Goal (MDG) 10, Target 3, i.e., to halve the proportion of underweight children under 5 years old by 2015. The United Nations Food and Agriculture Organization (FAO), the World Health Organization (WHO), the United Nations Children's Fund (UNICEF), the World Food Programme (WFP), and the International Fund for Agricultural Development (IFAD) developed and tested a facilitation mechanism to act as a catalyst for scaling up multisectoral nutrition activities. The UN-REACH partners developed pilot projects in Mauritania and Lao PDR from 2008 to 2010 and deployed facilitators to improve nutrition governance and coordination. Review missions were conducted in February 2011 to assess the REACH approach and what it achieved. The UN review mission members reviewed documents, assessed policy and management indicators, conducted qualitative interviews, and discussed findings with key stakeholders, including the most senior UN nutrition directors from all agencies. Among other UN-REACH achievements, the Prime Minister of Mauritania agreed to preside over a new National Nutrition Development Council responsible for high-level decision-making and setting national policy objectives. REACH facilitated the completion of Lao's first national Nutrition Strategy and Plan of Action and formation of the multistakeholder Nutrition Task Force. During the REACH engagement, coordination, joint advocacy, situation analysis, policy development, and joint UN programming for nutrition were strengthened in Lao PDR and Mauritania. Improvements in the nutrition governance and management mechanisms in Mauritania and Lao PDR were observed during the period of REACH support through increased awareness of nutrition as a key development objective, establishment of governmental multisectoral coordinating mechanisms, improved government capacity, and new joint UN-government nutrition

  1. Accelerating the Adoption of Second-Tier Reach Standards forApplicable Appliance Products in China

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Jiang; Fridley, David

    2007-03-01

    The minimum energy efficiency standards program for household appliances in China was initiated in 1989. Since 1996, CLASP and its implementing partner, LBNL, have assisted China in developing 11 minimum energy performance standards (MEPS) for 9 products and endorsement labels for 11 products including: refrigerators; air conditioners; clothes washers; televisions; printers; computers; monitors; fax machines; copiers; DVD/VCD players; external power supplies; and set-top boxes (under development). Before 2003, China's traditional approach to standards development involved small increases in efficiency requirements for implementation within 6 months of a standard's approval. Since 2003, China has adopted a new approach in setting MEPS. This new approach involves the development of two tiers of standards--one for initial implementation and a second tier at a more aggressive level of energy efficiency for implementation three to five years later. The second-tier standard is also referred to as a 'reach standard'. Reach standards have now been developed in China for: color TVs; refrigerators; air conditioners; and external power supplies. This report is presented in five sections. After the introduction in Section 1, Section 2 analyzes the distribution of the efficiency of refrigerators and air-conditioners in China based on data collected by the China Energy Label Center for the mandatory energy information label program. The results provide an assessment of the adoption of reach standards for these two products. Section 3 summarizes on-going collaborations with Shanghai related to early local adoption of reach standards, and presents both the impact and an analysis of barriers to the local adoption of reach standard for air-conditioners. Section 4 offers suggestions for local governments on how to move forward in adopting reach standards in their localities and concludes with a summary of the results and a plan for developing local capacity in

  2. Action without awareness: reaching to an object you do not remember seeing.

    Directory of Open Access Journals (Sweden)

    Matthew Heath

    Full Text Available BACKGROUND: Previous work by our group has shown that the scaling of reach trajectories to target size is independent of obligatory awareness of that target property and that "action without awareness" can persist for up to 2000 ms of visual delay. In the present investigation we sought to determine if the ability to scale reaching trajectories to target size following a delay is related to the pre-computing of movement parameters during initial stimulus presentation or the maintenance of a sensory (i.e., visual representation for on-demand response parameterization. METHODOLOGY/PRINCIPAL FINDINGS: Participants completed immediate or delayed (i.e., 2000 ms perceptual reports and reaching responses to different sized targets under non-masked and masked target conditions. For the reaching task, the limb associated with a trial (i.e., left or right was not specified until the time of response cuing: a manipulation that prevented participants from pre-computing the effector-related parameters of their response. In terms of the immediate and delayed perceptual tasks, target size was accurately reported during non-masked trials; however, for masked trials only a chance level of accuracy was observed. For the immediate and delayed reaching tasks, movement time as well as other temporal kinematic measures (e.g., times to peak acceleration, velocity and deceleration increased in relation to decreasing target size across non-masked and masked trials. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that speed-accuracy relations were observed regardless of whether participants were aware (i.e., non-masked trials or unaware (i.e., masked trials of target size. Moreover, the equivalent scaling of immediate and delayed reaches during masked trials indicates that a persistent sensory-based representation supports the unconscious and metrical scaling of memory-guided reaching.

  3. Automated River Reach Definition Strategies: Applications for the Surface Water and Ocean Topography Mission

    Science.gov (United States)

    Frasson, Renato Prata de Moraes; Wei, Rui; Durand, Michael; Minear, J. Toby; Domeneghetti, Alessio; Schumann, Guy; Williams, Brent A.; Rodriguez, Ernesto; Picamilh, Christophe; Lion, Christine; Pavelsky, Tamlin; Garambois, Pierre-André

    2017-10-01

    The upcoming Surface Water and Ocean Topography (SWOT) mission will measure water surface heights and widths for rivers wider than 100 m. At its native resolution, SWOT height errors are expected to be on the order of meters, which prevent the calculation of water surface slopes and the use of slope-dependent discharge equations. To mitigate height and width errors, the high-resolution measurements will be grouped into reaches (˜5 to 15 km), where slope and discharge are estimated. We describe three automated river segmentation strategies for defining optimum reaches for discharge estimation: (1) arbitrary lengths, (2) identification of hydraulic controls, and (3) sinuosity. We test our methodologies on 9 and 14 simulated SWOT overpasses over the Sacramento and the Po Rivers, respectively, which we compare against hydraulic models of each river. Our results show that generally, height, width, and slope errors decrease with increasing reach length. However, the hydraulic controls and the sinuosity methods led to better slopes and often height errors that were either smaller or comparable to those of arbitrary reaches of compatible sizes. Estimated discharge errors caused by the propagation of height, width, and slope errors through the discharge equation were often smaller for sinuosity (on average 8.5% for the Sacramento and 6.9% for the Po) and hydraulic control (Sacramento: 7.3% and Po: 5.9%) reaches than for arbitrary reaches of comparable lengths (Sacramento: 8.6% and Po: 7.8%). This analysis suggests that reach definition methods that preserve the hydraulic properties of the river network may lead to better discharge estimates.

  4. Characterisation of the Whole Blood mRNA Transcriptome in Holstein-Friesian and Jersey Calves in Response to Gradual Weaning.

    Directory of Open Access Journals (Sweden)

    D Johnston

    Full Text Available Weaning of dairy calves is an early life husbandry management practice which involves the changeover from a liquid to a solid feed based diet. The objectives of the study were to use RNA-seq technology to examine the effect of (i breed and (ii gradual weaning, on the whole blood mRNA transcriptome of artificially reared Holstein-Friesian and Jersey calves. The calves were gradually weaned over 14 days (day (d -13 to d 0 and mRNA transcription was examined one day before gradual weaning was initiated (d -14, one day after weaning (d 1, and 8 days after weaning (d 8. On d -14, 550 genes were differentially expressed between Holstein-Friesian and Jersey calves, while there were 490 differentially expressed genes (DEG identified on d 1, and 411 DEG detected eight days after weaning (P 0.05. The pathways, gene ontology terms, and biological functions consistently over-represented among the DEG between Holstein-Friesian and Jersey were associated with the immune response and immune cell signalling, specifically chemotaxis. Decreased transcription of several cytokines, chemokines, immunoglobulin-like genes, phagocytosis-promoting receptors and g-protein coupled receptors suggests decreased monocyte, natural killer cell, and T lymphocyte, chemotaxis and activation in Jersey compared to Holstein-Friesian calves. Knowledge of breed-specific immune responses could facilitate health management practices better tailored towards specific disease sensitivities of Holstein-Friesian and Jersey calves. Gradual weaning did not compromise the welfare of artificially-reared dairy calves, evidenced by the lack of alterations in the expression of any genes in response to gradual weaning.

  5. Task-dependent vestibular feedback responses in reaching.

    Science.gov (United States)

    Keyser, Johannes; Medendorp, W Pieter; Selen, Luc P J

    2017-07-01

    When reaching for an earth-fixed object during self-rotation, the motor system should appropriately integrate vestibular signals and sensory predictions to compensate for the intervening motion and its induced inertial forces. While it is well established that this integration occurs rapidly, it is unknown whether vestibular feedback is specifically processed dependent on the behavioral goal. Here, we studied whether vestibular signals evoke fixed responses with the aim to preserve the hand trajectory in space or are processed more flexibly, correcting trajectories only in task-relevant spatial dimensions. We used galvanic vestibular stimulation to perturb reaching movements toward a narrow or a wide target. Results show that the same vestibular stimulation led to smaller trajectory corrections to the wide than the narrow target. We interpret this reduced compensation as a task-dependent modulation of vestibular feedback responses, tuned to minimally intervene with the task-irrelevant dimension of the reach. These task-dependent vestibular feedback corrections are in accordance with a central prediction of optimal feedback control theory and mirror the sophistication seen in feedback responses to mechanical and visual perturbations of the upper limb. NEW & NOTEWORTHY Correcting limb movements for external perturbations is a hallmark of flexible sensorimotor behavior. While visual and mechanical perturbations are corrected in a task-dependent manner, it is unclear whether a vestibular perturbation, naturally arising when the body moves, is selectively processed in reach control. We show, using galvanic vestibular stimulation, that reach corrections to vestibular perturbations are task dependent, consistent with a prediction of optimal feedback control theory. Copyright © 2017 the American Physiological Society.

  6. Bimanual reach to grasp movements after cervical spinal cord injury.

    Directory of Open Access Journals (Sweden)

    Laura Britten

    Full Text Available Injury to the cervical spinal cord results in bilateral deficits in arm/hand function reducing functional independence and quality of life. To date little research has been undertaken to investigate control strategies of arm/hand movements following cervical spinal cord injury (cSCI. This study aimed to investigate unimanual and bimanual coordination in patients with acute cSCI using 3D kinematic analysis as they performed naturalistic reach to grasp actions with one hand, or with both hands together (symmetrical task, and compare this to the movement patterns of uninjured younger and older adults. Eighteen adults with a cSCI (mean 61.61 years with lesions at C4-C8, with an American Spinal Injury Association (ASIA grade B to D and 16 uninjured younger adults (mean 23.68 years and sixteen uninjured older adults (mean 70.92 years were recruited. Participants with a cSCI produced reach-to-grasp actions which took longer, were slower, and had longer deceleration phases than uninjured participants. These differences were exacerbated during bimanual reach-to-grasp tasks. Maximal grasp aperture was no different between groups, but reached earlier by people with cSCI. Participants with a cSCI were less synchronous than younger and older adults but all groups used the deceleration phase for error correction to end the movement in a synchronous fashion. Overall, this study suggests that after cSCI a level of bimanual coordination is retained. While there seems to be a greater reliance on feedback to produce both the reach to grasp, we observed minimal disruption of the more impaired limb on the less impaired limb. This suggests that bimanual movements should be integrated into therapy.

  7. The profile of attention differs between locations orthogonal to and in line with reach direction.

    Science.gov (United States)

    Stewart, Emma E M; Ma-Wyatt, Anna

    2017-11-01

    People make movements in a variety of directions when interacting with the world around them. It has been well documented that attention shifts to the goal of an upcoming movement, whether the movement is a saccade or a reach. However, recent evidence suggests that the direction of a movement may influence the spatial spread of attention (Stewart & Ma-Wyatt, 2015, Journal of Vision, 15(5), 10). We investigated whether the spatiotemporal profile of attention differs depending on where that location is situated relative to the direction of movement, and if this pattern is consistent across different movement effectors. We compared attentional facilitation at locations in line with or orthogonal to the movement, for reach-only, reach-plus-saccade, and saccade-only conditions. Results show that the spatiotemporal profile of attention differs across different movement combinations, and is also different at target locations orthogonal to and in line with the movement direction. Specifically, when a reach alone was made, there was a general decrease in attention at all locations during the movement and a general increase in attention at all locations with a saccade only. However, the concurrent reach and saccade condition showed a premovement attentional facilitation at locations orthogonal to movement direction, but not those in line with the movement direction. These results suggest attentional guidance may be more important at differing time points, depending on the type of movement.

  8. Channel evolution under changing hydrological regimes in anabranching reaches downstream of the Three Gorges Dam

    Science.gov (United States)

    Han, Jianqiao; Zhang, Wei; Yuan, Jing; Fan, Yongyang

    2018-03-01

    Elucidating the influence of dams on fluvial processes can benefit river protection and basin management. Based on hydrological and topographical data, we analyzed channel evolution in anabranching reaches under changing hydrological regimes influenced by the Three Gorges Dam. The main conclusions are as follows: 1) the channels of specific anabranching reaches were defined as flood trend channels or low-flow trend channels according to the distribution of their flow characteristics. The anabranching reaches were classified as T1 or T2. The former is characterized by the correspondence between the flood trend and branch channels, and the latter is characterized by the correspondence between the flood trend and main channels; 2) on the basis of the new classification, the discrepant patterns of channel evolution seen in anabranching reaches were unified into a pattern that showed flood trend channels shrinking and low-flow trend channels expanding; 3) flood abatement and the increased duration of moderate flow discharges are the main factors that affect channel adjustments in anabranching reaches after dam construction; and 4) in the next few decades, the pattern of channel evolution will remain the same as that of the Three Gorges Dam operation. That is, the morphology will fully adapt to a flow with a low coefficient of variation. Our results are of interest in the management of the Yangtze River and other rivers influenced by dams.

  9. Evaluating Remapped Physical Reach for Hand Interactions with Passive Haptics in Virtual Reality.

    Science.gov (United States)

    Han, Dustin T; Suhail, Mohamed; Ragan, Eric D

    2018-04-01

    Virtual reality often uses motion tracking to incorporate physical hand movements into interaction techniques for selection and manipulation of virtual objects. To increase realism and allow direct hand interaction, real-world physical objects can be aligned with virtual objects to provide tactile feedback and physical grasping. However, unless a physical space is custom configured to match a specific virtual reality experience, the ability to perfectly match the physical and virtual objects is limited. Our research addresses this challenge by studying methods that allow one physical object to be mapped to multiple virtual objects that can exist at different virtual locations in an egocentric reference frame. We study two such techniques: one that introduces a static translational offset between the virtual and physical hand before a reaching action, and one that dynamically interpolates the position of the virtual hand during a reaching motion. We conducted two experiments to assess how the two methods affect reaching effectiveness, comfort, and ability to adapt to the remapping techniques when reaching for objects with different types of mismatches between physical and virtual locations. We also present a case study to demonstrate how the hand remapping techniques could be used in an immersive game application to support realistic hand interaction while optimizing usability. Overall, the translational technique performed better than the interpolated reach technique and was more robust for situations with larger mismatches between virtual and physical objects.

  10. Muscle Synergies Control during Hand-Reaching Tasks in Multiple Directions Post-stroke

    Directory of Open Access Journals (Sweden)

    Sharon Israely

    2018-02-01

    Full Text Available Purpose: A muscle synergies model was suggested to represent a simplifying motor control mechanism by the brainstem and spinal cord. The aim of the study was to investigate the feasibility of such control mechanisms in the rehabilitation of post-stroke individuals during the execution of hand-reaching movements in multiple directions, compared to non-stroke individuals.Methods: Twelve non-stroke and 13 post-stroke individuals participated in the study. Muscle synergies were extracted from EMG data that was recorded during hand reaching tasks, using the NMF algorithm. The optimal number of synergies was evaluated in both groups using the Variance Accounted For (VAF and the Mean Squared Error (MSE. A cross validation procedure was carried out to define a representative set of synergies. The similarity index and the K-means algorithm were applied to validate the existence of such a set of synergies, but also to compare the modulation properties of synergies for different movement directions between groups. The similarity index and hierarchical cluster analysis were also applied to compare between group synergies.Results: Four synergies were chosen to optimally capture the variances in the EMG data, with mean VAF of 0.917 ± 0.034 and 0.883 ± 0.046 of the data variances, with respective MSE of 0.007 and 0.016, in the control and study groups, respectively. The representative set of synergies was set to be extracted from movement to the center of the reaching space. Two synergies had different muscle activation balance between groups. Seven and 17 clusters partitioned the muscle synergies of the control and study groups. The control group exhibited a gradual change in the activation in the amplitude in the time domain (modulation of synergies, as reflected by the similarity index, whereas the study group exhibited consistently significant differences between all movement directions and the representative set of synergies. The study findings support

  11. Translating the REACH Caregiver Intervention for Use by Area Agency on Aging Personnel: the REACH OUT Program

    Science.gov (United States)

    Burgio, Louis D.; Collins, Irene B.; Schmid, Bettina; Wharton, Tracy; McCallum, Debra; DeCoster, Jamie

    2009-01-01

    Purpose: The aim of this study was to translate the evidence-based Resources for Enhancing Alzheimer's Caregiver Health (REACH) II intervention for use in 4 Area Agencies on Aging (AAAs). A secondary aim was to examine possible moderators of treatment outcome. Design and Methods: We used a quasi-experimental pre-post treatment design with no…

  12. Redesigning Schools to Reach Every Student with Excellent Teachers: Change Management--Key Theories to Consider when Extending Reach

    Science.gov (United States)

    Barrett, Sharon Kebschull

    2012-01-01

    As schools, their teachers, and outside facilitators redesign jobs and incorporate technology to extend the reach of excellent teachers to more students and develop an Opportunity Culture for all, choosing the right school models is just one part of the task. The human experience--and experience in education--says that even perfect design will not…

  13. Perceiver as polar planimeter: Direct perception of jumping, reaching, and jump-reaching affordances for the self and others.

    Science.gov (United States)

    Thomas, Brandon J; Hawkins, Matthew M; Nalepka, Patrick

    2017-03-30

    Runeson (Scandanavian Journal of Psychology 18:172-179, 1977) suggested that the polar planimeter might serve as an informative model system of perceptual mechanism. The key aspect of the polar planimeter is that it registers a higher order property of the environment without computational mediation on the basis of lower order properties, detecting task-specific information only. This aspect was posited as a hypothesis for the perception of jumping and reaching affordances for the self and another person. The findings supported this hypothesis. The perception of reaching while jumping significantly differed from an additive combination of jump-without-reaching and reach-without-jumping perception. The results are consistent with Gibson's (The senses considered as perceptual systems, Houghton Mifflin, Boston, MA; Gibson, The senses considered as perceptual systems, Houghton Mifflin, Boston, MA, 1966; The ecological approach to visual perception, Houghton Mifflin, Boston, MA; Gibson, The ecological approach to visual perception, Houghton Mifflin, Boston, MA, 1979) theory of information-that aspects of the environment are specified by patterns in energetic media.

  14. Simulation of Columbia River Floods in the Hanford Reach

    Energy Technology Data Exchange (ETDEWEB)

    Waichler, Scott R.; Serkowski, John A.; Perkins, William A.; Richmond, Marshall C.

    2017-01-30

    Columbia River water elevations and flows in the Hanford Reach affect the environment and facilities along the shoreline, including movement of contaminants in groundwater, fish habitat, and infrastructure subject to flooding. This report describes the hydraulic simulation of hypothetical flood flows using the best available topographic and bathymetric data for the Hanford Reach and the Modular Aquatic Simulation System in 1 Dimension (MASS1) hydrodynamic model. The MASS1 model of the Hanford Reach was previously calibrated to field measurements of water surface elevations. The current model setup can be used for other studies of flow, water levels, and temperature in the Reach. The existing MASS1 channel geometry and roughness and other model configuration inputs for the Hanford Reach were used for this study, and previous calibration and validation results for the model are reprinted here for reference. The flood flows for this study were simulated by setting constant flow rates obtained from the U.S. Army Corps of Engineers (USACE) for the Columbia, Snake, and Yakima Rivers, and a constant water level at McNary Dam, and then running the model to steady state. The discharge levels simulated were all low-probability events; for example, a 100-year flood is one that would occur on average every 100 years, or put another way, in any given year there is a 1% chance that a discharge of that level or higher will occur. The simulated floods and their corresponding Columbia River discharges were 100-year (445,000 cfs), 500-year (520,000 cfs), and the USACE-defined Standard Project Flood (960,000 cfs). The resulting water levels from the steady-state floods can be viewed as “worst case” outcomes for the respective discharge levels. The MASS1 output for water surface elevations was converted to the North American Vertical Datum of 1988 and projected across the channel and land surface to enable mapping of the floodplain for each scenario. Floodplain maps show that for

  15. Pre-announcements of price increase intentions in liner shipping spot markets

    DEFF Research Database (Denmark)

    Chen, Gang; Rytter, Niels G M; Jiang, Liping

    2017-01-01

    competition perspective, which will indirectly indicate whether carriers are able to manipulate spot rates following GRI announcements. Taking the Far East–North Europe trade between 2009 and 2013 as an example, the paper first reveals the gradual increase of GRI frequency and size, which reflects carriers...... factors, in sequence of explanation power, are the total capacity of GRI carriers, the idling fleet size, the spot rate level, and the average ship-loading factor. Clearly the latter three factors are market fundamentals, which are unlikely to be influenced by an individual carrier in the short term....... In actual fact, the conclusion reached is that there is little evidence that carriers can manipulate and distort spot rates through GRIs...

  16. Integrated testing strategy (ITS) for bioaccumulation assessment under REACH

    DEFF Research Database (Denmark)

    Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio

    2014-01-01

    in a dossier. REACH promotes the use of alternative methods to replace, refine and reduce the use of animal (eco)toxicity testing. Within the EU OSIRIS project, integrated testing strategies (ITSs) have been developed for the rational use of non-animal testing approaches in chemical hazard assessment. Here we......REACH (registration, evaluation, authorisation and restriction of chemicals) regulation requires that all the chemicals produced or imported in Europe above 1 tonne/year are registered. To register a chemical, physicochemical, toxicological and ecotoxicological information needs to be reported...... present an ITS for evaluating the bioaccumulation potential of organic chemicals. The scheme includes the use of all available data (also the non-optimal ones), waiving schemes, analysis of physicochemical properties related to the end point and alternative methods (both in silico and in vitro). In vivo...

  17. Key Design Requirements for Long-Reach Manipulators

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, D.S.

    2001-01-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented.

  18. Key design requirements for long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.; March-Leuba, S.; Babcock, S.M.; Hamel, W.R.

    1993-09-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional kinematic, and performance requirements an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented

  19. Key Design Requirements for Long-Reach Manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.

    2001-01-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented

  20. Using Facebook to Reach People Who Experience Auditory Hallucinations

    OpenAIRE

    Crosier, Benjamin Sage; Brian, Rachel Marie; Ben-Zeev, Dror

    2016-01-01

    Background Auditory hallucinations (eg, hearing voices) are relatively common and underreported false sensory experiences that may produce distress and impairment. A large proportion of those who experience auditory hallucinations go unidentified and untreated. Traditional engagement methods oftentimes fall short in reaching the diverse population of people who experience auditory hallucinations. Objective The objective of this proof-of-concept study was to examine the viability of leveraging...

  1. Developing human health exposure scenarios for petroleum substances under REACH

    Energy Technology Data Exchange (ETDEWEB)

    Carter, M.; De Wilde, P.; Maksimainen, K.; Margary, A.; Money, C.; Pizzella, G.; Svanehav, T.; Tsang, W.; Urbanus, J.; Rohde, A.

    2012-12-15

    This report describes the approaches that were adopted by CONCAWE to prepare the human exposure estimates in the chemical safety assessments of the REACH registration dossiers for petroleum substances based on all applicable regulatory guidance. Separate exposure estimates were developed for workers and for consumers and included inhalation and dermal routes. The complex nature of petroleum substances required various scientifically justified refinements of the regulatory guidance.

  2. The processing of visual and auditory information for reaching movements.

    Science.gov (United States)

    Glazebrook, Cheryl M; Welsh, Timothy N; Tremblay, Luc

    2016-09-01

    Presenting target and non-target information in different modalities influences target localization if the non-target is within the spatiotemporal limits of perceptual integration. When using auditory and visual stimuli, the influence of a visual non-target on auditory target localization is greater than the reverse. It is not known, however, whether or how such perceptual effects extend to goal-directed behaviours. To gain insight into how audio-visual stimuli are integrated for motor tasks, the kinematics of reaching movements towards visual or auditory targets with or without a non-target in the other modality were examined. When present, the simultaneously presented non-target could be spatially coincident, to the left, or to the right of the target. Results revealed that auditory non-targets did not influence reaching trajectories towards a visual target, whereas visual non-targets influenced trajectories towards an auditory target. Interestingly, the biases induced by visual non-targets were present early in the trajectory and persisted until movement end. Subsequent experimentation indicated that the magnitude of the biases was equivalent whether participants performed a perceptual or motor task, whereas variability was greater for the motor versus the perceptual tasks. We propose that visually induced trajectory biases were driven by the perceived mislocation of the auditory target, which in turn affected both the movement plan and subsequent control of the movement. Such findings provide further evidence of the dominant role visual information processing plays in encoding spatial locations as well as planning and executing reaching action, even when reaching towards auditory targets.

  3. Taking family planning services to hard-to-reach populations.

    Science.gov (United States)

    Donovan, P

    1996-01-01

    Interviews were conducted in 1995 among 100 US family planning program personnel who serve hard-to-reach populations, such as drug abusers, prisoners, the disabled, homeless persons, and non-English speaking minorities. Findings indicate that a range of services is available for hard-to-reach groups. Most family planning agencies focus on drug abusers because of the severity of HIV infections and the availability of funding. This article describes the activities of various agencies in Michigan, Pennsylvania, and Massachusetts that serve substance abuse centers with family planning services. One recommendation for a service provider is to present services in an environment where it is safe to talk about a person's needs. One other program offered personal greetings upon arrival and the continuity of having a familiar face to oversee all reproductive and health needs. Programs for prisoners ranged from basic sex education classes to comprehensive reproductive health care. Some prisons offered individual counseling. Some programs were presented in juvenile offender facilities. Outreach to the homeless involved services at homeless shelters, outreach workers who recruited women into traditional family planning clinics, and establishment of nontraditional sites for the homeless and other hard-to-reach persons. One provider's suggestion was to offer services where high-risk women already go for other services. Most services to the disabled target the developmentally disabled rather than the physically disabled. Experience has shown that many professionals working with the disabled do not recognize their clients' sexual needs. Other hard-to-reach groups include women in housing projects and shelters for battered women, welfare applicants, and sex workers. Key to service provision is creating trust, overcoming language and cultural differences, and subsidizing the cost of care.

  4. Effect of Gradual Heating and Fat/Oil Type on Fat Stability, Texture, Color, and Microstructure of Meat Batters.

    Science.gov (United States)

    Barbut, S; Youssef, M K

    2016-09-01

    The effects of endpoint cooking temperature (40, 50, 60, 70, 80, and 90 °C) on emulsion stability, texture, color, and microstructure of meat batters prepared with different fats/oils were studied. Canola oil treatments showed the highest cooking loss whereas hydrogenated palm oil provided the most stable meat batters. Rendered beef fat was less stable than regular beef fat. Increasing endpoint cooking temperatures resulted in a progressive reduction of water holding capacity in all treatments. As temperature was raised, meat batters showed higher hardness and cohesiveness values, but no appreciable changes in cohesiveness above 60 °C. Canola and hydrogenated palm oil treatments showed the highest hardness and chewiness values. Lightness (L(*) ) values of all meat batters increased significantly with increasing temperature from 40 to 60 or 70 °C; no major changes observed above 70 °C. Light microscopy revealed no substantial changes in the microstructure of all the stable meat batters cooked to between 50 and 70 °C. Heating to 90 °C changed the microstructure in all meat batters except the hydrogenated palm oil treatments, which still showed nonround fat particles and a less aggregated protein matrix. © 2016 Institute of Food Technologists®

  5. International reach of tobacco marketing among young children.

    Science.gov (United States)

    Borzekowski, Dina L G; Cohen, Joanna E

    2013-10-01

    Prosmoking messages, delivered through marketing and the media, can reach very young children and influence attitudes and behaviors around smoking. This study examined the reach of tobacco marketing to 5 and 6 year olds in 6 low- and middle-income countries. Researchers worked one-on-one with 5 and 6 year olds in Brazil, China, India, Nigeria, Pakistan, and Russia (N = 2423). The children were asked to match logos with pictures of products, including 8 logos for cigarette brands. Analyses examined, overall and by country, whether gender, age, location, household use of tobacco, and knowledge of media characters were associated with awareness of cigarette brand logos. Additional analyses considered the relationship between cigarette brand logo awareness and intentions to smoke. Overall, 68% of 5 and 6 year olds could identify at least 1 cigarette brand logo, ranging from 50% in Russia to 86% in China. Across countries, being slightly older and having someone in the household who used tobacco, were significantly associated with greater odds of being able to identify at least 1 cigarette brand logo. The majority of young children from low- and middle-income countries are familiar with cigarette brands. This study's findings suggest that more effective measures are needed to restrict the reach of tobacco marketing.

  6. The German REACH Congress 2016: a workshop report.

    Science.gov (United States)

    Reihlen, Antonia; Jepsen, Dirk; Broschinski, Lutz; Luch, Andreas; Schulte, Agnes

    2018-03-01

    In October 2016, the German REACH Congress was held at the German Federal Institute for Risk Assessment (BfR) in Berlin. Here, the associated improvement made in the fields of consumer protection and the progress in and experiences gained from the implementation of the authorisation procedure were discussed. Several speakers from EU institutions, German authorities, industry, and civil society organisations were invited to present their views. There was a shared consensus that REACH contributes to the advancement of consumer protection against chemical risks, mainly because more and higher quality information on substance-related hazards and potential exposures becomes available. In addition, risk management measures, particularly regarding restrictions on uses, scale down consumer exposures to chemicals. Opportunities for improvements identified at the congress include the quality of registration dossiers and the management of and communication on substances of very high concern (SVHC) that may be present in consumer articles. Although regarded as being in an early implementation phase, the authorisation process was generally found to be operational and progressing well. Criticism was expressed with regard to the consistency of authorisation decisions and the costs and uncertainties related to authorisation applications. Consumer protection legislation consists of several legal provisions which are interlinked. The congress participants agreed that REACH is an important element of this legal framework as it enhances and complements other legal provisions.

  7. Do older adults perceive postural constraints for reach estimation?

    Science.gov (United States)

    Cordova, Alberto; Gabbard, Carl

    2014-01-01

    BACKGROUND/STUDY CONTEXT: Recent evidence indicates that older persons have difficulty mentally representing intended movements. Furthermore, in an estimation of reach paradigm using motor imagery, a form of mental representation, older persons significantly overestimated their ability compared with young adults. The authors tested the notion that older adults may also have difficulty perceiving the postural constraints associated with reach estimation. The authors compared young (Mage = 22 years) and older (Mage = 67) adults on reach estimation while seated and in a more postural demanding standing and leaning forward position. The expectation was a significant postural effect with the standing condition, as evidenced by reduced overestimation. Whereas there was no difference between groups in the seated condition (both overestimated), older adults underestimated whereas the younger group once again overestimated in the standing condition. From one perspective, these results show that older adults do perceive postural constraints in light of their own physical capabilities. That is, that group perceived greater postural demands with the standing posture and elected to program a more conservative strategy, resulting in underestimation.

  8. Distractor interference during a choice limb reaching task.

    Directory of Open Access Journals (Sweden)

    Matthew Ray

    Full Text Available According to action-centered models of attention, the patterns of distractor interference that emerge in selective reaching tasks are related to the time and effort required to resolve a race for activation between competing target and non-target response producing processes. Previous studies have only used unimanual aiming tasks and, as such, only examined the effects of competition that occurs within a limb. The results of studies using unimanual aiming movements often reveal an "ipsilateral effect"--distractors on the same side of space as the effector cause greater interference than distractors on the opposite side of space. The cost of the competition when response selection is between the limbs has yet to be addressed. Participants in the present study executed reaching movements to 1 of 4 (2 left, 2 right possible target locations with and without a distractor. Participants made ipsilateral reaches (left hand to left targets, right hand to right targets. In contrast to studies using unimanual aiming movements, a "contralateral effect" was observed; distractors affording responses for the other hand (in contralateral space caused more interference than distractors affording responses for the same hand. The findings from the present research demonstrate that when certain portions of response planning must be resolved prior to response initiation, distractors that code for that dimension cause the greatest interference.

  9. Flowing equation gradually varied in rectangles channels on depth curve; Ecuacion del flujo gradualmente variado en canales rectangulares de fondo curvo

    Energy Technology Data Exchange (ETDEWEB)

    Sotelo-Avila, G.; Gallegos-Silva, J. [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)

    2002-03-01

    The study of channel flow usually have its basis in the hydrostatic distribution of pressure and the rectilinear flow hypotheses. It is from this hypothesis that the main flow equations are obtained. However, this is not applicable to a vertically curved flow that is present in a curved bed channel. This kind of channel is used to join two different slopes or in ski jumps. This kind of flow presents several changes from the rectilinear flow as in the velocity and pressure distributions and even in the energy loses. The authors of this article propose an equation of gradually varied flow for vertically-curved bed rectangular channels that adds a coefficient to modify the velocity in the calculus of the local friction gradient. With these results is possible now to analyze flow profiles in vertically-curved bed channels where before were used the methods for straight channels and therefore, increase accuracy. [Spanish] Las hipotesis del movimiento rectilineo y de distribucion hidrostatica de la presion son ciertamente las mas importantes en la hidraulica de canales, y de ellas se derivan los principales modelos de flujo que usualmente emplean. Sin embargo, no es valido aplicar la misma hipotesis y metodos de analisis al flujo curvilineo, que ocurre cuando el canal adopta curvaturas verticales en el fondo, las cuales inducen cambios importantes en la distribucion de la velocidad, presion y hasta en la perdida d energia. Tal es el caso de canales que contienen curvas verticales para unir tramos de distintas pendientes y producir el cambio en la direccion del flujo en cubetas deflectoras y vertedores en tunel. Los autores de este articulo proponen una ecuacion de flujo gradualmente variado en canales rectangulares de fondo curvo, esta es de gran utilidad en la determinacion del perfil del flujo con dichas caracteristicas, donde se plantea la adicion de un factor de amplificacion de la velocidad en el calculo del gradiente local de friccion, para tomar en cuenta el

  10. Mechanical energy expenditures and movement efficiency in full body reaching movements.

    Science.gov (United States)

    Sha, Daohang; France, Christopher R; Thomas, James S

    2010-02-01

    The effect of target location, speed, and handedness on the average total mechanical energy and movement efficiency is studied in 15 healthy subjects (7 males and 8 females with age 22.9 +/- 1.79 years old) performing full body reaching movements. The average total mechanical energy is measured as the time average of integration of joint power, potential energy, and kinetic energy respectively. Movement efficiency is calculated as the ratio of total kinetic energy to the total joint power and potential energy. Results show that speed and target location have significant effects on total mechanical energy and movement efficiency, but reaching hand only effects kinetic energy. From our findings we conclude that (1) efficiency in whole body reaching is dependent on whether the height of the body center of mass is raised or lowered during the task; (2) efficiency is increased as movement speed is increased, in part because of greater changes in potential energy; and (3) the CNS does not appear to use movement efficiency as a primary planning variable in full body reaching. It may be dependent on a combination of other factors or constraints.

  11. Why and how to make a REACH registration of combustion ash; Moejligheter vid REACH-registrering av energiaskor

    Energy Technology Data Exchange (ETDEWEB)

    Loevgren, Linnea; Wik, Ola

    2009-10-15

    The new chemical regulation, REACH (1997/2006/EC), Registration, Evaluation, Authorization and restriction of Chemicals, took effect the 1st of June 2007. The background to this report was the introduction of REACH and the difficulties to understand the implications for ash. The most important consequence of REACH is that all chemical substances that are manufactured, handled and used above one tonne per annum per legal entity shall be registered according to this regulation. The registration includes specifying the chemical, physical, toxicity and ecotoxicity properties of the substance and risk assessing the identified areas of use. The report describes the use of ash in connection to the waste legislation and its planned end-of-waste-criteria, the chemical legislation and the Construction Products Directive. The target audience of this report is companies producing ashes and having a use or seeing a use for its ash. The report describes how to make a REACH registration of ash independent if a company did or did not pre-register ash during 2008. It describes how to change from one ash registration into another if the pre-registration was done for one type of ash but the company changes opinion during the sameness check, i.e. changing SIEF (Appendix A). Taking part in REACH registration projects during 2009-2010 can be advantageous since knowledge and financing are shared. Ash can be REACH registered also in the future but it is important to know that the registration have to be done prior the production and marketing starts. If ash is consider to be a waste the handling is covered by the community and national waste legislation. In Sweden ashes are by and large being regarded as waste, and recycling is risk assessed and permits are given case by case. End-of-waste criteria for different waste material are being elaborated within the EU. Such criteria will among other details cover chemical safety. When a material fulfils the end-of-waste criteria such material

  12. Professional practical knowledge on the evolution of a collage physics course in the school research approach, in the light of the gradualness hypothesis

    Directory of Open Access Journals (Sweden)

    John Freddy Ramírez Casallas

    2012-09-01

    Full Text Available Since 2001 an experience in physics teaching regarding the research school model has been carried out inside the engineering program of an university. The complexity in its development in the Colombian region of Tolima has demanded to respond specific difficulties; such as the recognition and overcoming of the training problems that bring our students to the classroom. In previous reports has been based and proposed the development of a physical with a regional sense in which it is essential the gradual approach to this model (gradualness hypothesis based on the premise that the majority of students have had access to a traditional teaching of the subject during secondary education. This report is intended, based on a process of practice systematization to introduce, conceptualize, support and raise interesting concerns around the successful development the course has had, since an option close to the traditional to one oriented by school research tasks.

  13. Going deep : new generation of giant rigs extends drillers' reach

    International Nuclear Information System (INIS)

    Laverty Wilson, K.

    2001-01-01

    The Eirik Roude, an offshore super rig, arrived in Halifax Harbour from Florida in the summer 2001 for a retrofit before it is sent to work in the rugged environment offshore of Nova Scotia. The drilling platform is a joint venture between PanCanadian Petroleum and Ocean Rig. Is is the most technologically advanced and sophisticated deep water drilling platform in the world and can operate in 3,000 metre deep water for 365 days of the year. It is a fifth-generation semi-submersible rig. It floats on long legs that lower the centre of gravity below surface turbulence to provide a stable work platform even during Atlantic storms. The 110 metre long rig has three mud systems that store 593 cubic metres in mud pits, 1,260 cubic metres in pontoons, and can carry 26,140 barrels of fuel oil, 4,070 barrels of potable water and 13,210 barrels of drilling water. PanCanadian has provided $2 million to the Nova Scotia Community College to teach an appropriate curriculum for the required workforce. It is expected that 120 local workers will be recruited. PanCanadian plans to drill 3 or 4 offshore wells annually for the next 5 years. It is estimated that 700-800 workers will be on site at the peak of the retrofit. In addition, Marathon Oil has contracted the Smedvig-owned West Navion for Nova Scotia work. This vessel is designed to work in depths of up to 2,500 metres and can be upgraded to reach 3,000 metres. Its' dual handling capacity makes it suitable to do drilling and well completion simultaneously, thereby reducing the halts in operations and increasing the drilling efficiency. East Coast governments and trade associations are also committed to make the most of the offshore oil and gas revival, including the development of a petrochemical market. Their goal is to build a world class energy sector while protecting the environment and optimizing the financial, economic and social benefits to Nova Scotians. The Nova Scotia Benefits program requires that oil companies

  14. Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs

    DEFF Research Database (Denmark)

    Shen, René L.; Thymann, Thomas; Østergaard, Mette V.

    2015-01-01

    It is unclear when and how to start enteral feeding for preterm infants when mother’s milk is not available. We hypothesized that early and slow advancement with either formula or bovine colostrum stimulates gut maturation and prevents necrotizing enterocolitis (NEC) in preterm pigs, used as models...... for preterm infants. Pigs were given either total parenteral nutrition (TPN, n = 14) or slowly advancing volumes (16–64 ml·kg-1·day-1) of preterm infant formula (IF, n = 15) or bovine colostrum (BC, n = 13), both given as adjunct to parenteral nutrition. On day 5, both enteral diets increased intestinal mass...... intestinal permeability, compared with BC pigs (all P colostrum supports gut maturation when mother’s milk is absent during the first week after preterm birth...

  15. Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs

    DEFF Research Database (Denmark)

    Shen, Rene L; Thymann, Thomas; Østergaard, Mette V

    2015-01-01

    It is unclear when and how to start enteral feeding for preterm infants when mother's milk is not available. We hypothesized that early and slow advancement with either formula or bovine colostrum stimulates gut maturation and prevents necrotizing enterocolitis (NEC) in preterm pigs, used as models...... for preterm infants. Pigs were given either total parenteral nutrition (TPN, n = 14) or slowly advancing volumes (16–64 ml·kg−1·day−1) of preterm infant formula (IF, n = 15) or bovine colostrum (BC, n = 13), both given as adjunct to parenteral nutrition. On day 5, both enteral diets increased intestinal mass......), and higher intestinal permeability, compared with BC pigs (all P colostrum supports gut maturation when mother's milk is absent during the first week after...

  16. Restoring Maximum Vertical Browsing Reach in Sauropod Dinosaurs.

    Science.gov (United States)

    Paul, Gregory S

    2017-10-01

    The ongoing controversy centered on neck posture and function in sauropod dinosaurs is misplaced for a number of reasons. Because of an absence of pertinent data it is not possible to accurately restore the posture and range of motion in long necked fossil animals, only gross approximations are possible. The existence of a single "neutral posture" in animals with long, slender necks may not exist, and its relationship to feeding habits is weak. Restorations of neutral osteological neck posture based on seemingly detailed diagrams of cervical articulations are not reliable because the pictures are not sufficiently accurate due to a combination of illustration errors, and distortion of the fossil cervicals. This is all the more true because fossil cervical series lack the critical inter-centra cartilage. Maximum vertical reach is more readily restorable and biologically informative for long necked herbivores. Modest extension of 10° between each caudal cervical allowed high shouldered sauropods to raise the cranial portion of their necks to vertical postures that allowed them to reach floral resources far higher than seen in the tallest mammals. This hypothesis is supported by the dorsally extended articulation of the only known co-fused sauropod cervicals. Many sauropods appear to have been well adapted for rearing in order to boost vertical reach, some possessed retroverted pelves that may have allowed them to walk slowly while bipedal. A combination of improved high browsing abilities and sexual selection probably explains the unusually long necks of tall ungulates and super tall sauropods. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:1802-1825, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  17. SPECTRAL PROPERTIES OF LARGE GRADUAL SOLAR ENERGETIC PARTICLE EVENTS. II. SYSTEMATIC Q/M DEPENDENCE OF HEAVY ION SPECTRAL BREAKS

    Energy Technology Data Exchange (ETDEWEB)

    Desai, M. I.; Dayeh, M. A.; Ebert, R. W.; Schwadron, N. A. [Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78238 (United States); Mason, G. M. [Johns Hopkins University/Applied Physics Laboratory, Laurel, MD 20723 (United States); McComas, D. J. [Department of Astrophysical Sciences, Princeton University, NJ 08544 (United States); Li, G. [The Center for Space Plasma and Aeronomic Research (CSPAR), University of Alabama in Huntsville, Huntsville, AL 35756 (United States); Cohen, C. M. S.; Mewaldt, R. A. [California Institute of Technology, Pasadena, CA 91125 (United States); Smith, C. W., E-mail: mdesai@swri.edu [University of New Hampshire, 8 College Road, Durham NH 03824 (United States)

    2016-09-10

    We fit ∼0.1–500 MeV nucleon{sup −1} H–Fe spectra in 46 large solar energetic particle (SEP) events with the double power-law Band function to obtain a normalization constant, low- and high-energy parameters γ {sub a} and γ {sub b}, and break energy E {sub B}, and derive the low-energy spectral slope γ {sub 1}. We find that: (1) γ {sub a}, γ {sub 1}, and γ {sub b} are species-independent and the spectra steepen with increasing energy; (2) E {sub B} decreases systematically with decreasing Q/M scaling as (Q/M){sup α}; (3) α varies between ∼0.2–3 and is well correlated with the ∼0.16–0.23 MeV nucleon{sup −1} Fe/O; (4) in most events, α < 1.4, γ {sub b}– γ {sub a} > 3, and O E {sub B} increases with γ {sub b}– γ {sub a}; and (5) in many extreme events (associated with faster coronal mass ejections (CMEs) and GLEs), Fe/O and {sup 3}He/{sup 4}He ratios are enriched, α ≥ 1.4, γ {sub b}– γ {sub a} < 3, and E {sub B} decreases with γ {sub b}– γ {sub a}. The species-independence of γ {sub a}, γ {sub 1}, and γ {sub b} and the Q/M dependence of E {sub B} within an event and the α values suggest that double power-law SEP spectra occur due to diffusive acceleration by near-Sun CME shocks rather than scattering in interplanetary turbulence. Using γ {sub 1}, we infer that the average compression ratio for 33 near-Sun CME shocks is 2.49 ± 0.08. In most events, the Q/M dependence of E {sub B} is consistent with the equal diffusion coefficient condition and the variability in α is driven by differences in the near-shock wave intensity spectra, which are flatter than the Kolmogorov turbulence spectrum but weaker than the spectra for extreme events. In contrast, in extreme events, enhanced wave power enables faster CME shocks to accelerate impulsive suprathermal ions more efficiently than ambient coronal ions.

  18. Improving Posthospital Discharge Telephone Reach Rates Through Prehospital Discharge Face-to-Face Meetings.

    Science.gov (United States)

    Vergara, Franz H; Sheridan, Daniel J; Sullivan, Nancy J; Budhathoki, Chakra

    The purpose of this study was to determine whether a face-to-face meeting with patients by a telephonic case manager prehospital discharge would result in increased telephone follow-up (TFU) reach rates posthospital discharge. Acute care adult medicine inpatient units. A quasiexperimental design was utilized. Two adult inpatient medicine units were selected as the intervention and comparison groups. The framework of the study is the transitions theory. A convenience sampling technique was used, whereby 88 eligible patients on the intervention unit received face-to-face meetings prehospital discharge whereas 123 patients on the comparison unit received standard care (no face-to-face meetings). Cross-tabulation and chi-square tests were employed to examine the association of face-to-face meeting intervention and TFU reach rates. Implementing brief (face-to-face meetings by a telephonic case manager prehospital discharge resulted in a TFU reach rate of 87% on the intervention unit, whereas the comparison unit only had a 58% TFU reach rate (p communication with more patients posthospital discharge. A brief prehospital discharge face-to-face meeting with patients assisted them to understand the reasons for a posthospital discharge telephone call, identified the best times to call using accurate telephone numbers, and taught patients how best to prepare for the call. In addition, by meeting patients face-to-face, the telephonic case manager was no longer an unknown person on the telephone asking them questions about their medical condition. These factors combined may have significantly helped to increase TFU reach rates.

  19. Vestibular feedback maintains reaching accuracy during body movement

    Science.gov (United States)

    Reynolds, Raymond F.

    2016-01-01

    Key points Reaching movements can be perturbed by vestibular input, but the function of this response is unclear.Here, we applied galvanic vestibular stimulation concurrently with real body movement while subjects maintained arm position either fixed in space or fixed with respect to their body.During the fixed‐in‐space conditions, galvanic vestibular stimulation caused large changes in arm trajectory consistent with a compensatory response to maintain upper‐limb accuracy in the face of body movement.Galvanic vestibular stimulation responses were absent during the body‐fixed task, demonstrating task dependency in vestibular control of the upper limb.The results suggest that the function of vestibular‐evoked arm movements is to maintain the accuracy of the upper limb during unpredictable body movement, but only when reaching in an earth‐fixed reference frame. Abstract When using our arms to interact with the world, unintended body motion can introduce movement error. A mechanism that could detect and compensate for such motion would be beneficial. Observations of arm movements evoked by vestibular stimulation provide some support for this mechanism. However, the physiological function underlying these artificially evoked movements is unclear from previous research. For such a mechanism to be functional, it should operate only when the arm is being controlled in an earth‐fixed rather than a body‐fixed reference frame. In the latter case, compensation would be unnecessary and even deleterious. To test this hypothesis, subjects were gently rotated in a chair while being asked to maintain their outstretched arm pointing towards either earth‐fixed or body‐fixed memorized targets. Galvanic vestibular stimulation was applied concurrently during rotation to isolate the influence of vestibular input, uncontaminated by inertial factors. During the earth‐fixed task, galvanic vestibular stimulation produced large polarity‐dependent corrections in arm

  20. Optical fiber reach extended FMCW radar for remote respiratory tracking

    DEFF Research Database (Denmark)

    Suhr, Lau Frejstrup; Tafur Monroy, Idelfonso; Vegas Olmos, Juan José

    2017-01-01

    Wireless monitoring of human vital signs such as breathing rate is a nonintrusive alternative to contemporary solutions relying on physical contact. To ease the installment, fiber optical transmission is used to extend the reach from the transmitter and receiver circuitry to the antenna subsystem....... In this paper, a frequency modulated carrier wave radar, operating at 25.7–26.6 GHz and utilizing optical fiber extension, was experimentally demonstrated to accurately recover the breathing rate of a human placed 1 m away from the radar antennas....

  1. Family (oikos Evangelism for reaching forward caste Hindus in India

    Directory of Open Access Journals (Sweden)

    DW Fowlkes

    2006-09-01

    Full Text Available This article acknowledges the need for Church Planting Movements among the unreached peoples of India. Of particular concern to this study is the application of Church Planting Movement strategy to forward caste Hindus of India. It is shown that evangelizing households (family or �oikos� evangelism is a New Testament strategy and the most appropriate strategy for reaching forward caste Hindus. It is concluded that Christian disciples remaining within Hindu culture and familial systems hold the potential for the most indigenous approach to evangelizing forward caste Hindus.

  2. THE REACH OF TWITTER AS A POLITICAL TOOL

    Directory of Open Access Journals (Sweden)

    Vanessa González Mendoza

    2010-07-01

    Full Text Available The massive growth of Internet and all the possibilities that it offers, have made us beings of instant gratification. The need to know, to be informed, and to communicate at all times, stands above many other things, and rules our daily life. Tools like Twitter provide the citizen a way in which they can express their ideas, either to be heard or to make a change even in the political atmosphere. This article searches to determine the influence and the reach of Twitter in the political activism of a country.

  3. Interaction torque contributes to planar reaching at slow speed

    Directory of Open Access Journals (Sweden)

    Hoshi Fumihiko

    2008-10-01

    Full Text Available Abstract Background How the central nervous system (CNS organizes the joint dynamics for multi-joint movement is a complex problem, because of the passive interaction among segmental movements. Previous studies have demonstrated that the CNS predictively compensates for interaction torque (INT which is arising from the movement of the adjacent joints. However, most of these studies have mainly examined quick movements, presumably because the current belief is that the effects of INT are not significant at slow speeds. The functional contribution of INT for multijoint movements performed in various speeds is still unclear. The purpose of this study was to examine the contribution of INT to a planer reaching in a wide range of motion speeds for healthy subjects. Methods Subjects performed reaching movements toward five targets under three different speed conditions. Joint position data were recorded using a 3-D motion analysis device (50 Hz. Torque components, muscle torque (MUS, interaction torque (INT, gravity torque (G, and net torque (NET were calculated by solving the dynamic equations for the shoulder and elbow. NET at a joint which produces the joint kinematics will be an algebraic sum of torque components; NET = MUS - G - INT. Dynamic muscle torque (DMUS = MUS-G was also calculated. Contributions of INT impulse and DMUS impulse to NET impulse were examined. Results The relative contribution of INT to NET was not dependent on speed for both joints at every target. INT was additive (same direction to DMUS at the shoulder joint, while in the elbow DMUS counteracted (opposed to INT. The trajectory of reach was linear and two-joint movements were coordinated with a specific combination at each target, regardless of motion speed. However, DMUS at the elbow was opposed to the direction of elbow movement, and its magnitude varied from trial to trial in order to compensate for the variability of INT. Conclusion Interaction torque was important at

  4. Inertial torque during reaching directly impacts grip-force adaptation to weightless objects.

    Science.gov (United States)

    Giard, T; Crevecoeur, F; McIntyre, J; Thonnard, J-L; Lefèvre, P

    2015-11-01

    A hallmark of movement control expressed by healthy humans is the ability to gradually improve motor performance through learning. In the context of object manipulation, previous work has shown that the presence of a torque load has a direct impact on grip-force control, characterized by a significantly slower grip-force adjustment across lifting movements. The origin of this slower adaptation rate remains unclear. On the one hand, information about tangential constraints during stationary holding may be difficult to extract in the presence of a torque. On the other hand, inertial torque experienced during movement may also potentially disrupt the grip-force adjustments, as the dynamical constraints clearly differ from the situation when no torque load is present. To address the influence of inertial torque loads, we instructed healthy adults to perform visually guided reaching movements in weightlessness while holding an unbalanced object relative to the grip axis. Weightlessness offered the possibility to remove gravitational constraints and isolate the effect of movement-related feedback on grip force adjustments. Grip-force adaptation rates were compared with a control group who manipulated a balanced object without any torque load and also in weightlessness. Our results clearly show that grip-force adaptation in the presence of a torque load is significantly slower, which suggests that the presence of torque loads experienced during movement may alter our internal estimates of how much force is required to hold an unbalanced object stable. This observation may explain why grasping objects around the expected location of the center of mass is such an important component of planning and control of manipulation tasks.

  5. Training in intensive care medicine. A challenge within reach.

    Science.gov (United States)

    Castellanos-Ortega, A; Rothen, H U; Franco, N; Rayo, L A; Martín-Loeches, I; Ramírez, P; Cuñat de la Hoz, J

    2014-01-01

    The medical training model is currently immersed in a process of change. The new paradigm is intended to be more effective, more integrated within the healthcare system, and strongly oriented towards the direct application of knowledge to clinical practice. Compared with the established training system based on certification of the completion of a series or rotations and stays in certain healthcare units, the new model proposes a more structured training process based on the gradual acquisition of specific competences, in which residents must play an active role in designing their own training program. Training based on competences guarantees more transparent, updated and homogeneous learning of objective quality, and which can be homologated internationally. The tutors play a key role as the main directors of the process, and institutional commitment to their work is crucial. In this context, tutors should receive time and specific formation to allow the evaluation of training as the cornerstone of the new model. New forms of objective summative and training evaluation should be introduced to guarantee that the predefined competences and skills are effectively acquired. The free movement of specialists within Europe is very desirable and implies that training quality must be high and amenable to homologation among the different countries. The Competency Based training in Intensive Care Medicine in Europe program is our main reference for achieving this goal. Scientific societies in turn must impulse and facilitate all those initiatives destined to improve healthcare quality and therefore specialist training. They have the mission of designing strategies and processes that favor training, accreditation and advisory activities with the government authorities. Copyright © 2013 Elsevier España, S.L. y SEMICYUC. All rights reserved.

  6. Using an accelerometer for analyzing a reach-to-grasp movement after stroke

    Directory of Open Access Journals (Sweden)

    Stella Maris Michaelsen

    2013-12-01

    Full Text Available The purpose of this study was using an accelerometer to access the kinematics of reach-to-grasp movements in subjects with hemiparesis. Eight subjects (59.4 ± 6.9 years old with chronic hemiparesis (50.9 ± 25.8 months post-stroke participated in this study. Kinematic assessment was performed using a triaxial accelerometer (EMG Systems, Brazil attached to the subjects' forearm. Ten reach-to-grasp movements of grabbing a 500ml-size bottle were performed by the subjects with the paretic and the non-paretic upper limbs (ULs. The following space-temporal variables were calculated and used to compare the paretic and non-paretic ULs: movement time (MT, time to reach the peak velocity, absolute and relative (TPV and TPV%MT, relative deceleration duration (DEC%MT, time to peak acceleration (TPA and peak hand acceleration (PA. Movements were slower in the paretic UL with increased MT, TPA and DEC. The accelerometer allowed to identify of changes in reaching-to-grasp movements of subjects with hemiparesis. When complex systems are not available, accelerometers can be an alternative to measure UL movements.

  7. Hydraulic alterations resulting from hydropower development in the Bonneville Reach of the Columbia River

    Science.gov (United States)

    Hatten, James R.; Batt, Thomas R.

    2010-01-01

    We used a two-dimensional (2D) hydrodynamic model to simulate and compare the hydraulic characteristics in a 74-km reach of the Columbia River (the Bonneville Reach) before and after construction of Bonneville Dam. For hydrodynamic modeling, we created a bathymetric layer of the Bonneville Reach from single-beam and multi-beam echo-sounder surveys, digital elevation models, and navigation surveys. We calibrated the hydrodynamic model at 100 and 300 kcfs with a user-defined roughness layer, a variable-sized mesh, and a U.S. Army Corps of Engineers backwater curve. We verified the 2D model with acoustic Doppler current profiler (ADCP) data at 14 transects and three flows. The 2D model was 88% accurate for water depths, and 77% accurate for velocities. We verified a pre-dam 2D model run at 126 kcfs using pre-dam aerial photos from September 1935. Hydraulic simulations indicated that mean water depths in the Bonneville Reach increased by 34% following dam construction, while mean velocities decreased by 58%. There are numerous activities that would benefit from data output from the 2D model, including biological sampling, bioenergetics, and spatially explicit habitat modeling.

  8. An Effective Community?Academic Partnership to Extend the Reach of Screenings for Fall Risk

    OpenAIRE

    Schrodt, Lori A.; Garbe, Kathie C.; Chaplin, Rebecca; Busby-Whitehead, Jan; Shubert, Tiffany E.

    2013-01-01

    Older adults should be screened for fall risk annually. Community providers (people without formal medical training who work with older adults in senior centers or aging services) may be a viable group to expand the reach of screenings. Our community–academic partnership developed a program to increase and assess fall risk screenings by community providers. Community sites hosted training workshops and screening events. Community screenings were well attended and received by providers and old...

  9. Preparing to reach: selecting an adaptive long-latency feedback controller

    OpenAIRE

    Ahmadi-Pajouh, Mohammad Ali; Towhidkhah, Farzad; Shadmehr, Reza

    2012-01-01

    In a voluntary movement, the nervous system specifies not only the motor commands, but also the gains associated with reaction to sensory feedback. For example, suppose that during reaching a perturbation tends to push the hand to the left. With practice, the brain not only learns to produce commands that predictively compensate for the perturbation, but also increases the long-latency reflex gain associated with leftward displacements of the arm. That is, the brain learns a feedback controll...

  10. Successfully Changing the Landscape of Information Distribution: Extension Food Website Reaches People Locally and Globally

    OpenAIRE

    Alice Henneman; Lisa Franzen-Castle; Kayla Colgrove; Vishal Singh

    2016-01-01

    The goal of the Food website was to develop Internet-based content that was relevant and reached the general public and multiplier groups, such as educators, health professionals, and media outlets. The purpose of this paper was to examine whether a multi-modal approach to information delivery through increases in and changes to content, electronic mailing list creation, and social media posting impacted user access, traffic channels, and referrals from 2010 to 2014. When comparing 2010-2011 ...

  11. Livestock First Reached Southern Africa in Two Separate Events.

    Science.gov (United States)

    Sadr, Karim

    2015-01-01

    After several decades of research on the subject, we now know when the first livestock reached southern Africa but the question of how they got there remains a contentious topic. Debate centres on whether they were brought with a large migration of Khoe-speakers who originated from East Africa; or whether the livestock were traded down-the-line among hunter-gatherer communities; or indeed whether there was a long history of diverse small scale population movements in this part of the world, one or more of which 'infiltrated' livestock into southern Africa. A new analysis of the distribution of stone toolkits from a sizeable sample of sub-equatorial African Later Stone Age sites, coupled with existing knowledge of the distribution of the earliest livestock remains and ceramics vessels, has allowed us to isolate two separate infiltration events that brought the first livestock into southern Africa just over 2000 years ago; one infiltration was along the Atlantic seaboard and another entered the middle reaches of the Limpopo River Basin. These findings agree well with the latest results of genetic research which together indicate that multiple, small-scale infiltrations probably were responsible for bringing the first livestock into southern Africa.

  12. Record reach : ExxonMobil extends its own world record

    Energy Technology Data Exchange (ETDEWEB)

    Wells, P.

    2008-06-15

    Extended reach drilling (ERD) records are now regularly being broken by ExxonMobil Corporation's Sakhalin project on Russia's east coast. In 2008, an oil well on the coast established a new record by achieving a measured depth of 11,680 meters. The well was punched out by a Texas-based drilling company using the world's largest land-based drilling rig. The use of ERD has reduced the capital and operating costs of the project in addition to reducing its environmental impacts. ERD has been used to drill onshore beneath the seafloor and has eliminated the need for additional offshore structure and pipelines. The horizontal reach of the wells has improved productivity while also avoiding disturbing whale migrations in the region. The rig features a 1.5 million pound load capacity, 3000 horsepower draw-works. The top-drive drilling systems were used to transmit real time data to external locations for further evaluation. Oil and gas is also produced from a gravity-based offshore platform. It was concluded that longer wellbore are now being developed by the corporation in order to drill under the Beaufort Sea. 2 figs.

  13. Reaching the hip-hop generation: Final (symposium proceedings) report

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The goal of this final (closing) report is to capture the flavor of the symposium held March 1 and 2, 1993 in New York City convened by Motivational Educational Entertainment, Inc. (MEE), a black-owned communications research, consulting, and video production company based in Philadelphia, Pennsylvania. The mission of MEE is to understand, reach, and positively affect inner-city youth. Traditional communication approaches from mainstream sources to at-risk youth often don`t account for the unique way youth communicate among themselves and how they relate to the media. This understanding, however, is crucial. To understand youth communication, the people who create and send both entertaining and educational messages to urban youth must be brought into the dialogue. The meeting in New York was intended to provide an important opportunity for senders to meet and evaluate the appropriateness and effectiveness of their messages. In addition, the MEE symposium provided a forum for the continuing public debate about what needs to be done to reach today`s urban teens. Included in this document is a description of symposium goals/objectives, symposium activities, the reaction to and analysis of the symposium, recommendations for future MEE courses of action, and an appendix containing copies of press articles.

  14. Ricin A chain reaches the endoplasmic reticulum after endocytosis

    International Nuclear Information System (INIS)

    Liu Qiong; Zhan Jinbiao; Chen Xinhong; Zheng Shu

    2006-01-01

    Ricin is a potent ribosome inactivating protein and now has been widely used for synthesis of immunotoxins. To target ribosome in the mammalian cytosol, ricin must firstly retrograde transport from the endomembrane system to reach the endoplasmic reticulum (ER) where the ricin A chain (RTA) is recognized by ER components that facilitate its membrane translocation to the cytosol. In the study, the fusion gene of enhanced green fluorescent protein (EGFP)-RTA was expressed with the pET-28a (+) system in Escherichia coli under the control of a T7 promoter. The fusion protein showed a green fluorescence. The recombinant protein can be purified by metal chelated affinity chromatography on a column of NTA. The rabbit anti-GFP antibody can recognize the fusion protein of EGFP-RTA just like the EGFP protein. The cytotoxicity of EGFP-RTA and RTA was evaluated by the MTT assay in HeLa and HEP-G2 cells following fluid-phase endocytosis. The fusion protein had a similar cytotoxicity of RTA. After endocytosis, the subcellular location of the fusion protein can be observed with the laser scanning confocal microscopy and the immuno-gold labeling Electro Microscopy. This study provided important evidence by a visualized way to prove that RTA does reach the endoplasmic reticulum

  15. Google Hangouts: Leveraging Social Media to Reach the Education Community

    Science.gov (United States)

    Eisenhamer, Bonnie; Summers, Frank; McCallister, Dan; Ryer, Holly

    2015-01-01

    Research shows that educator professional development is most effective when it is sustained and/or when a follow-on component is included to support the learning process. In order to create more comprehensive learning experiences for our workshop participants, the education team at the Space Telescope Science Institute is working collaboratively with scientific staff and other experts to create a follow-on component for our professional development program. The new component utilizes video conferencing platforms, such as Google's Hangouts On Air, to provide educators with content updates and extended learning opportunities in between in-person professional development experiences. The goal is to enhance our professional development program in a cost-effective way while reaching a greater cross-section of educators. Video broadcasts go live on Google+, YouTube, and our website - thus providing access to any user with a web browser. Additionally, the broadcasts are automatically recorded and archived for future viewing on our YouTube channel. This provides educators with anywhere, anytime training that best suits their needs and schedules. This poster will highlight our new Hangouts for educators as well as our cross-departmental efforts to expand the reach of our Hubble Hangouts for the public through a targeted recruitment strategy.

  16. Adaptation to delayed force perturbations in reaching movements.

    Directory of Open Access Journals (Sweden)

    Noa Levy

    Full Text Available Adaptation to deterministic force perturbations during reaching movements was extensively studied in the last few decades. Here, we use this methodology to explore the ability of the brain to adapt to a delayed velocity-dependent force field. Two groups of subjects preformed a standard reaching experiment under a velocity dependent force field. The force was either immediately proportional to the current velocity (Control or lagged it by 50 ms (Test. The results demonstrate clear adaptation to the delayed force perturbations. Deviations from a straight line during catch trials were shifted in time compared to post-adaptation to a non-delayed velocity dependent field (Control, indicating expectation to the delayed force field. Adaptation to force fields is considered to be a process in which the motor system predicts the forces to be expected based on the state that a limb will assume in response to motor commands. This study demonstrates for the first time that the temporal window of this prediction needs not to be fixed. This is relevant to the ability of the adaptive mechanisms to compensate for variability in the transmission of information across the sensory-motor system.

  17. Generalization of unconstrained reaching with hand-weight changes.

    Science.gov (United States)

    Yan, Xiang; Wang, Qining; Lu, Zhengchuan; Stevenson, Ian H; Körding, Konrad; Wei, Kunlin

    2013-01-01

    Studies of motor generalization usually perturb hand reaches by distorting visual feedback with virtual reality or by applying forces with a robotic manipulandum. Whereas such perturbations are useful for studying how the central nervous system adapts and generalizes to novel dynamics, they are rarely encountered in daily life. The most common perturbations that we experience are changes in the weights of objects that we hold. Here, we use a center-out, free-reaching task, in which we can manipulate the weight of a participant's hand to examine adaptation and generalization following naturalistic perturbations. In both trial-by-trial paradigms and block-based paradigms, we find that learning converges rapidly (on a timescale of approximately two trials), and this learning generalizes mostly to movements in nearby directions with a unimodal pattern. However, contrary to studies using more artificial perturbations, we find that the generalization has a strong global component. Furthermore, the generalization is enhanced with repeated exposure of the same perturbation. These results suggest that the familiarity of a perturbation is a major factor in movement generalization and that several theories of the neural control of movement, based on perturbations applied by robots or in virtual reality, may need to be extended by incorporating prior influence that is characterized by the familiarity of the perturbation.

  18. Numerical model of the lowermost Mississippi River as an alluvial-bedrock reach: preliminary results

    Science.gov (United States)

    Viparelli, E.; Nittrouer, J. A.; Mohrig, D. C.; Parker, G.

    2012-12-01

    Recent field studies reveal that the river bed of the Lower Mississippi River is characterized by a transition from alluvium (upstream) to bedrock (downstream). In particular, in the downstream 250 km of the river, fields of actively migrating bedforms alternate with deep zones where a consolidated substratum is exposed. Here we present a first version of a one-dimensional numerical model able to capture the alluvial-bedrock transition in the lowermost Mississippi River, defined herein as the 500-km reach between the Old River Control Structure and the Gulf of Mexico. The flow is assumed to be steady, and the cross-section is divided in two regions, the river channel and the floodplain. The streamwise variation of channel and floodplain geometry is described with synthetic relations derived from field observations. Flow resistance in the river channel is computed with the formulation for low-slope, large sand bed rivers due to Wright and Parker, while a Chezy-type formulation is implemented on the floodplain. Sediment is modeled in terms of bed material and wash load. Suspended load is computed with the Wright-Parker formulation. This treatment allows either uniform sediment or a mixture of different grain sizes, and accounts for stratification effects. Bedload transport rates are estimated with the relation for sediment mixtures of Ashida and Michiue. Previous work documents reasonable agreement between these load relations and field measurements. Washload is routed through the system solving the equation of mass conservation of sediment in suspension in the water column. The gradual transition from the alluvial reach to the bedrock reach is modeled in terms of a "mushy" layer of specified thickness overlying the non-erodible substrate. In the case of a fully alluvial reach, the channel bed elevation is above this mushy layer, while in the case of partial alluvial cover of the substratum, the channel bed elevation is within the mushy layer. Variations in base

  19. Transparency of chemical risk assessment data under REACH.

    Science.gov (United States)

    Ingre-Khans, Ellen; Ågerstrand, Marlene; Beronius, Anna; Rudén, Christina

    2016-12-08

    The REACH regulation requires EU manufacturers and importers of substances to register information on the hazard and risk of their substances with the European Chemicals Agency (ECHA). Risk management of the substances is based on the provided information. It is known that conclusions on hazard and risk are influenced by expert judgements as well as potential conflict of interests. Thus, it is important that hazard and risk assessments are transparent and can be evaluated by a third party. The aim of this study is to scrutinize the transparency, i.e. the accessibility and comprehensibility, of information on substances registered under REACH. Data on repeated dose toxicity and hazard assessment conclusions were extracted for 60 substances from the REACH registration database available on the ECHA website. The data were compiled in a database for systematically evaluating the transparency of information related to the conclusions on hazard or risk. In addition, chemical safety reports (CSR) were requested from ECHA for five substances. The transparency of information on the hazard and risk of substances was found to be limited for several reasons. First, certain information was removed due to confidentiality and certain fields were not published because they could contain confidential information although the information had not been claimed confidential. Also, the extent to which registrants reported information varied, and the presentation of some data and certain terminology required further clarification. In addition, the data source for the majority of the key and supporting studies could not be identified due to confidentiality. Since registrants are only required to summarise studies, it cannot be verified whether all relevant information from non-public industry reports have been reported. Lastly, certain information related to the hazard and risk assessment were only reported in the CSR which is only available upon request; a time-consuming and work

  20. Modeling Regional Soil Water Balance in Farmland of the Middle Reaches of Heihe River Basin

    Directory of Open Access Journals (Sweden)

    Jiang Li

    2017-11-01

    Full Text Available Quantifying components of soil water balance in farmland of the middle reaches of Heihe River Basin is essential for efficiently scheduling and allocating limited water resources for irrigation in this arid region. A soil water balance model based on empirical assumptions in the vadose zone of farmland was developed and simulation results were compared/validated with results by the numerical model HYDRUS-1D. Results showed a good coherence between the simulated results of the water balance models and the HYDRUS-1D model in soil water storage, evapotranspiration, deep percolation and groundwater recharge, which indicated that the water balance model was suitable for simulating soil water movement in the study area. Considering the spatial distribution of cropping patterns, groundwater depth and agricultural management, ArcGIS was applied for the pre-/post-processing of the water balance model to quantify the spatial distribution of components of soil water balance in the major cropland in middle reaches of Heihe River Basin. Then, distributions of components of soil water balance in the major cropland under different water-saving irrigation practices during the growing season were predicted and discussed. Simulation results demonstrated that evapotranspiration of the main crops would be more prominently influenced by irrigation quota under deep groundwater depth than that under shallow groundwater depth. Groundwater recharge would increase with the increase of irrigation quota and decrease with the increase of groundwater depth. In general, when groundwater depth reached 3 m, groundwater recharge from root zone was negligible for spring wheat. While when it reached 6 m, groundwater recharge was negligible for maize. Water-saving irrigation practices would help to reduce groundwater recharge with a slight decrease of crop water consumption.

  1. Attenuating reaches and the regional flood response of an urbanizing drainage basin

    Science.gov (United States)

    Turner-Gillespie, Daniel F.; Smith, James A.; Bates, Paul D.

    The Charlotte, North Carolina metropolitan area has experienced extensive urban and suburban growth and sharply increasing trends in the magnitude and frequency of flooding. The hydraulics and hydrology of flood response in the region are examined through a combination of numerical modeling studies and diagnostic analyses of paired discharge observations from upstream-downstream gaging stations. The regional flood response is shown to strongly reflect urbanization effects, which increase flood peaks and decrease response times, and geologically controlled attenuating reaches, which decrease flood peaks and increase lag times. Attenuating reaches are characterized by systematic changes in valley bottom geometry and longitudinal profile. The morphology of the fluvial system is controlled by the bedrock geology, with pronounced changes occurring at or near contacts between intrusive igneous and metamorphic rocks. Analyses of wave celerity and flood peak attenuation over a range of discharge values for an 8.3 km valley bottom section of Little Sugar Creek are consistent with Knight and Shiono's characterization of the variation of flood wave velocity from in-channel conditions to valley bottom full conditions. The cumulative effect of variation in longitudinal profile, expansions and contractions of the valley bottom, floodplain roughness and sub-basin flood response is investigated using a two-dimensional, depth-averaged, finite element hydrodynamic model coupled with a distributed hydrologic model. For a 10.1 km stream reach of Briar Creek, with drainage area ranging from 13 km 2 at the upstream end of the reach to 49 km 2 at the downstream end, it is shown that flood response reflects a complex interplay of hydrologic and hydraulic processes on hillslopes and valley bottoms.

  2. Role of vision in aperture closure control during reach-to-grasp movements.

    Science.gov (United States)

    Rand, Miya K; Lemay, Martin; Squire, Linda M; Shimansky, Yury P; Stelmach, George E

    2007-08-01

    We have previously shown that the distance from the hand to the target at which finger closure is initiated during the reach (aperture closure distance) depends on the amplitude of peak aperture, as well as hand velocity and acceleration. This dependence suggests the existence of a control law according to which a decision to initiate finger closure during the reach is made when the hand distance to target crosses a threshold that is a function of the above movement-related parameters. The present study examined whether the control law is affected by manipulating the visibility of the hand and the target. Young adults made reach-to-grasp movements to a dowel under conditions in which the target or the hand or both were either visible or not visible. Reaching for and grasping a target when the hand and/or target were not visible significantly increased transport time and widened peak aperture. Aperture closure distance was significantly lengthened and wrist peak velocity was decreased only when the target was not visible. Further analysis showed that the control law was significantly different between the visibility-related conditions. When either the hand or target was not visible, the aperture closure distance systematically increased compared to its value for the same amplitude of peak aperture, hand velocity, and acceleration under full visibility. This implies an increase in the distance-related safety margin for grasping when the hand or target is not visible. It has been also found that the same control law can be applied to all conditions, if variables describing hand and target visibility were included in the control law model, as the parameters of the task-related environmental context, in addition to the above movement-related parameters. This suggests that that the CNS utilizes those variables for controlling grasp initiation based on a general control law.

  3. Changes in Purkinje cell simple spike encoding of reach kinematics during adaption to a mechanical perturbation.

    Science.gov (United States)

    Hewitt, Angela L; Popa, Laurentiu S; Ebner, Timothy J

    2015-01-21

    The cerebellum is essential in motor learning. At the cellular level, changes occur in both the simple spike and complex spike firing of Purkinje cells. Because simple spike discharge reflects the main output of the cerebellar cortex, changes in simple spike firing likely reflect the contribution of the cerebellum to the adapted behavior. Therefore, we investigated in Rhesus monkeys how the representation of arm kinematics in Purkinje cell simple spike discharge changed during adaptation to mechanical perturbations of reach movements. Monkeys rapidly adapted to a novel assistive or resistive perturbation along the direction of the reach. Adaptation consisted of matching the amplitude and timing of the perturbation to minimize its effect on the reach. In a majority of Purkinje cells, simple spike firing recorded before and during adaptation demonstrated significant changes in position, velocity, and acceleration sensitivity. The timing of the simple spike representations change within individual cells, including shifts in predictive versus feedback signals. At the population level, feedback-based encoding of position increases early in learning and velocity decreases. Both timing changes reverse later in learning. The complex spike discharge was only weakly modulated by the perturbations, demonstrating that the changes in simple spike firing can be independent of climbing fiber input. In summary, we observed extensive alterations in individual Purkinje cell encoding of reach kinematics, although the movements were nearly identical in the baseline and adapted states. Therefore, adaption to mechanical perturbation of a reaching movement is accompanied by widespread modifications in the simple spike encoding. Copyright © 2015 the authors 0270-6474/15/351106-19$15.00/0.

  4. Reaching out to the hard to reach: using a science centre model to deliver public engagement with research.

    Science.gov (United States)

    Gagen, M.; Allton, C.; Bryan, W. A.; O'Leary, M.

    2017-12-01

    Science communication is at an all-time high but public faith in expertise is low. However, within this climate of suspicion, research scientists remain a publicly trusted expert group. While there is both academic and public appetite for Public Engagement with Research (PER), there are barriers to reaching a wide range of publics. Attempts to connect the public with research often end up targeting the `already engaged'; the hard-to-reach remain just that. Engaging scientific curiosity in a wider demographic is crucial to promote scientific curiosity, itself known to profoundly counter the politically motivated reasoning that threatens informed debate around contemporary environmental issues. This requires the creation of opportunities for the public to engage with research in places in which they feel they belong. We report here on an 8 month pilot of a science centre model for PER. Oriel Science (www.orielscience.co.uk) is a research-led science exhibition in Swansea city centre delivering Swansea University's PER and run by academics and student ambassadors. Oriel Science (Oriel is Gallery in Welsh) received 16,000 visitors in 8 months, 40% of whom had no previous interaction with the university or its research and >40% of whom came from socio-economically deprived areas. We report on the public engagement leadership we enabled, working with 18 research groups over 8 months and our achievements in giving a broad range of publics the most direct access to participate in contemporary science.

  5. Naturalness reach of the large hadron collider in minimal supergravity

    International Nuclear Information System (INIS)

    Allanach, B.C.; Hetherington, J.P.J.; Parker, M.A.; Webber, B.R.

    2000-01-01

    We re-analyse the prospects of discovering supersymmetry at the LHC, in order to re-express coverage in terms of a fine-tuning parameter and to extend the analysis to scalar masses (m 0 ) above 2 TeV. We use minimal supergravity (mSUGRA) unification assumptions for the SUSY breaking parameters. Such high values of m 0 have recently been found to have a focus point, leading to relatively low fine-tuning. In addition, improvements in the simulations since the last study mean that this region no longer lacks radiative electroweak symmetry breaking. The best fine tuning reach is found in a mono-leptonic channel, where for μ>0, A 0 =0 and tan β=10 (corresponding to the focus point), all points in mSUGRA with m 0 0 , mSUGRA does not evade detection provided the gaugino mass parameter M 1/2 < 460 GeV. (author)

  6. The contributions of vision and haptics to reaching and grasping

    Directory of Open Access Journals (Sweden)

    Kayla Dawn Stone

    2015-09-01

    Full Text Available This review aims to provide a comprehensive outlook on the sensory (visual and haptic contributions to reaching and grasping. The focus is on studies in developing children, normal and neuropsychological populations, and in sensory-deprived individuals. Studies have suggested a right-hand/left-hemisphere specialization for visually-guided grasping and a left-hand/right-hemisphere specialization for haptically-guided object recognition. This poses the interesting possibility that when vision is not available and grasping relies heavily on the haptic system, there is an advantage to use the left hand. We review the evidence for this possibility and dissect the unique contributions of the visual and haptic systems to grasping. We ultimately discuss how the integration of these two sensory modalities shape hand preference.

  7. Undoing Racism Through Genesee County's REACH Infant Mortality Reduction Initiative.

    Science.gov (United States)

    Kruger, Daniel J; Carty, Denise C; Turbeville, Ashley R; French-Turner, Tonya M; Brownlee, Shannon

    2015-01-01

    Genesee County Racial and Ethnic Approaches to Community Health Program (REACH) is a Community-Based Public Health partnership for reducing African American infant mortality rates that hosts the Undoing Racism Workshop (URW). Assess the URW's effectiveness in promoting an understanding of racism, institutional racism, and how issues related to race/ethnicity can affect maternal and infant health. Recent URW participants (n=84) completed brief preassessment and postassessment forms; participants (n=101) also completed an on-line, long-term assessment (LTA). URWs promoted understanding of racism and institutional racism, although they were less effective in addressing racism as related to maternal and infant health. The URWs were most effective in the domains related to their standard content. Additional effort is necessary to customize URWs when utilized for activities beyond their original purpose of community mobilization.

  8. Impact of measles supplementary immunization activities on reaching children missed by routine programs.

    Science.gov (United States)

    Portnoy, Allison; Jit, Mark; Helleringer, Stéphane; Verguet, Stéphane

    2018-01-02

    Measles supplementary immunization activities (SIAs) are vaccination campaigns that supplement routine vaccination programs with a recommended second dose opportunity to children of different ages regardless of their previous history of measles vaccination. They are conducted every 2-4 years and over a few weeks in many low- and middle-income countries. While SIAs have high vaccination coverage, it is unclear whether they reach the children who miss their routine measles vaccine dose. Determining who is reached by SIAs is vital to understanding their effectiveness, as well as measure progress towards measles control. We examined SIAs in low- and middle-income countries from 2000 to 2014 using data from the Demographic and Health Surveys. Conditional on a child's routine measles vaccination status, we examined whether children participated in the most recent measles SIA. The average proportion of zero-dose children (no previous routine measles vaccination defined as no vaccination date before the SIA) reached by SIAs across 14 countries was 66%, ranging from 28% in São Tomé and Príncipe to 91% in Nigeria. However, when also including all children with routine measles vaccination data, this proportion decreased to 12% and to 58% when imputing data for children with vaccination reported by the mother and vaccination marks on the vaccination card across countries. Overall, the proportions of zero-dose children reached by SIAs declined with increasing household wealth. Some countries appeared to reach a higher proportion of zero-dose children using SIAs than others, with proportions reached varying according to the definition of measles vaccination (e.g., vaccination dates on the vaccination card, vaccination marks on the vaccination card, and/or self-reported data). This suggests that some countries could improve their targeting of SIAs to children who miss other measles vaccine opportunities. Across all countries, SIAs played an important role in reaching

  9. Visuo-proprioceptive interactions during adaptation of the human reach.

    Science.gov (United States)

    Judkins, Timothy; Scheidt, Robert A

    2014-02-01

    We examined whether visual and proprioceptive estimates of transient (midreach) target capture errors contribute to motor adaptation according to the probabilistic rules of information integration used for perception. Healthy adult humans grasped and moved a robotic handle between targets in the horizontal plane while the robot generated springlike loads that varied unpredictably from trial to trial. For some trials, a visual cursor faithfully tracked hand motion. In others, the handle's position was locked and subjects viewed motion of a point-mass cursor driven by hand forces. In yet other trials, cursor feedback was dissociated from hand motion or altogether eliminated. We used time- and frequency-domain analyses to characterize how sensorimotor memories influence performance on subsequent reaches. When the senses were used separately, subjects were better at rejecting physical disturbances applied to the hand than virtual disturbances applied to the cursor. In part, this observation reflected differences in how participants used sensorimotor memories to adapt to perturbations when performance feedback was limited to only proprioceptive or visual information channels. When both vision and proprioception were available to guide movement, subjects processed memories in a manner indistinguishable from the vision-only condition, regardless of whether the cursor tracked the hand faithfully or whether we experimentally dissociated motions of the hand and cursor. This was true even though, on average, perceptual uncertainty in the proprioceptive estimation of movement extent exceeded that of visual estimation by just 47%. In contrast to perceptual tasks wherein vision and proprioception both contribute to an optimal estimate of limb state, our findings support a switched-input, multisensory model of predictive load compensation wherein visual feedback of transient performance errors overwhelmingly dominates proprioception in determining adaptive reach performance.

  10. The Economic Cost of China's New De-sulfur Policy During Her Gradual Accession to WTO: The Case of Industrial SO2 Emission

    OpenAIRE

    Jie He

    2004-01-01

    To understand the potential impacts of China's accession to WTO in her new de-sulfur policy (gradual reduction of 10% of annual SO2 emission by 2005 with respect to that of 2000), we construct a CGE model in which SO2 emission is directly linked to energy input consumption in production. The model equally considers the substitution possibility between energies of different SO2 effluent ratio by including energy as traditional production factor as labor and capital in the constant elasticity o...

  11. Gradual digital lengthening with autologous bone graft and external fixation for correction of flail toe in a patient with Raynaud's disease.

    Science.gov (United States)

    Lamm, Bradley M; Ades, Joe K

    2009-01-01

    Iatrogenic flail toe is a complication of hammertoe surgery that occurs when an overaggressive resection of the proximal phalanx occurs. This can cause both functional and cosmetic concerns for the patient. We present a case report of the correction of a flail second toe in a patient with Raynaud's disease. The correction was achieved by means of gradual soft tissue lengthening with external fixation and an interposition autologous bone graft digital arthrodesis. After 5 months, this 2-stage procedure lengthened, stabilized, and restored the function of the toe. 4.

  12. Reaching those most in need: a review of diabetes self-management interventions in disadvantaged populations.

    Science.gov (United States)

    Eakin, Elizabeth G; Bull, Sheana S; Glasgow, Russell E; Mason, Mondi

    2002-01-01

    There has been increased recognition of the importance of developing diabetes self-management education (DSME) interventions that are effective with under-served and minority populations. Despite several recent studies in this area, there is to our knowledge no systematic review or synthesis of what has been learned from this research. An electronic literature search identified five formative evaluations and ten controlled DSME intervention trials focused on under-served (low-income, minority or aged) populations. The RE-AIM (Reach, Efficacy, Adoption, Implementation, Maintenance) evaluation framework was used to evaluate the controlled studies on the dimensions of reach, efficacy, adoption, implementation, and maintenance. Fifty percent of the studies identified reported on the percentage of patients who participated, and the percentages were highly variable. The methodological quality of the articles was generally good and the short-term results were encouraging, especially on behavioral outcomes. Data on adoption (representativeness of settings and clinicians who participate) and implementation were almost never reported. Studies of modalities in addition to group meetings are needed to increase the reach of DSME with under-served populations. The promising formative evaluation work that has been conducted needs to be extended for more systematic study of the process of intervention implementation and adaptation with special populations. Studies that explicitly address the community context and that address multiple issues related to public health impact of DSME interventions are recommended to enhance long-term results. Copyright 2002 John Wiley & Sons, Ltd.

  13. Characteristics of radium isotopes in the middle and lower reaches of the Yangtze river

    International Nuclear Information System (INIS)

    Su Ni; Du Jinzhou; Duan Zonglian

    2010-01-01

    The paper studied the distribution pattern of radium isotopes in the middle and lower reaches of the Yangtze River based on the cruise survey in Jan. 2008. The results showed that dissolved 226 Ra and 228 Ra activities varied stably around 1.17-2.37 Bq/m 3 and 1.47-3.28 Bq/m 3 in the middle reaches, while they increased in the lower reaches. Dissolved Ra activities were much higher in the Dongting and the Poyang Lakes. The particulate Ra activity was found to increase downstream. Additionally, the yearly flux of dissolved Ra from the river to the ocean was estimated based on the monthly measured Ra activity in the Xuliujing and the runoff. The estimated flux varied between 0.74 x 10 12 -1.96 x 10 12 Bq/y. The dissolved Ra activity was found largest in the Yangtze estuary, medium in the Yangtze River, and smallest in the East China Sea. It indicated the filter effect of the Yangtze estuary to the fate of terrestrial Ra. (authors)

  14. Modulation of hand aperture during reaching in persons with incomplete cervical spinal cord injury.

    Science.gov (United States)

    Stahl, Victoria A; Hayes, Heather B; Buetefisch, Cathrin M; Wolf, Steven L; Trumbower, Randy D

    2015-03-01

    The intact neuromotor system prepares for object grasp by first opening the hand to an aperture that is scaled according to object size and then closing the hand around the object. After cervical spinal cord injury (SCI), hand function is significantly impaired, but the degree to which object-specific hand aperture scaling is affected remains unknown. Here, we hypothesized that persons with incomplete cervical SCI have a reduced maximum hand opening capacity but exhibit novel neuromuscular coordination strategies that permit object-specific hand aperture scaling during reaching. To test this hypothesis, we measured hand kinematics and surface electromyography from seven muscles of the hand and wrist during attempts at maximum hand opening as well as reaching for four balls of different diameters. Our results showed that persons with SCI exhibited significantly reduced maximum hand aperture compared to able-bodied (AB) controls. However, persons with SCI preserved the ability to scale peak hand aperture with ball size during reaching. Persons with SCI also used distinct muscle coordination patterns that included increased co-activity of flexors and extensors at the wrist and hand compared to AB controls. These results suggest that motor planning for aperture modulation is preserved even though execution is limited by constraints on hand opening capacity and altered muscle co-activity. Thus, persons with incomplete cervical SCI may benefit from rehabilitation aimed at increasing hand opening capacity and reducing flexor-extensor co-activity at the wrist and hand.

  15. Malaria Cases in the U.S. Reach 40-Year High: Information and Guidance for Clinicians

    Centers for Disease Control (CDC) Podcasts

    This podcast is an overview of the Clinician Outreach and Communication Activity (COCA) Call: Malaria Cases in the U.S. Reach 40-Year High: Information and Guidance for Clinicians. The number of malaria cases reported in the United States in 2011 was the largest since 1971, representing a 14 percent increase from 2010 and a 48 percent increase from 2008. A CDC subject matter expert describes malaria prevention strategies aimed at reducing the risk of malaria in travelers, discusses the diagnosis of malaria in patients with suspect malaria, and explains the treatment options for confirmed malaria cases.

  16. Impact of Austrian hydropower plants on the flood control safety of the Hungarian Danube reach

    International Nuclear Information System (INIS)

    Zsuffa, I.

    1999-01-01

    Statistical analysis of daily water level data from four gauging stations along the Hungarian Danube reach has been carried out with the purpose of analysing the impact of the Austrian hydropower plants on the floods of the river. Conditional probability distribution functions of annual flood load maxima and annual number of floods were generated for the periods 1957-1976 and 1977-1996. By comparing these distribution functions, it could be shown that the flood load maxima have decreased, while the number of small and medium floods have increased during the past forty years. These changes indicate a decreased rate of flood superposition resulting from the barrages constructed in this period. The significantly decreased flood load maxima indicate that the Austrian barrage system has positive impact on the flood control safety of the Hungarian Danube reach

  17. Determining suitable dimensions for dairy goat feeding places by evaluating body posture and feeding reach.

    Science.gov (United States)

    Keil, Nina M; Pommereau, Marc; Patt, Antonia; Wechsler, Beat; Gygax, Lorenz

    2017-02-01

    Confined goats spend a substantial part of the day feeding. A poorly designed feeding place increases the risk of feeding in nonphysiological body postures, and even injury. Scientifically validated information on suitable dimensions of feeding places for loose-housed goats is almost absent from the literature. The aim of the present study was, therefore, to determine feeding place dimensions that would allow goats to feed in a species-appropriate, relaxed body posture. A total of 27 goats with a height at the withers of 62 to 80 cm were included in the study. Goats were tested individually in an experimental feeding stall that allowed the height difference between the feed table, the standing area of the forelegs, and a feeding area step (difference in height between forelegs and hind legs) to be varied. The goats accessed the feed table via a palisade feeding barrier. The feed table was equipped with recesses at varying distances to the feeding barrier (5-55 cm in 5-cm steps) at angles of 30°, 60°, 90°, 120°, or 150° (feeding angle), which were filled with the goats' preferred food. In 18 trials, balanced for order across animals, each animal underwent all possible combinations of feeding area step (3 levels: 0, 10, and 20 cm) and of difference in height between feed table and standing area of forelegs (6 levels: 0, 5, 10, 15, 20, and 25 cm). The minimum and maximum reach at which the animals could reach feed on the table with a relaxed body posture was determined for each combination. Statistical analysis was performed using mixed-effects models. The animals were able to feed with a relaxed posture when the feed table was at least 10 cm higher than the standing height of the goats' forelegs. Larger goats achieved smaller minimum reaches and minimum reach increased if the goats' head and neck were angled. Maximum reach increased with increasing height at withers and height of the feed table. The presence of a feeding area step had no influence on minimum and

  18. Simulating stream response to floodplain connectivity, reforestation and wetland restoration from reach to catchment scales

    Science.gov (United States)

    Singh, N.; Bomblies, A.; Wemple, B. C.; Ricketts, T.

    2017-12-01

    Natural infrastructure (e.g., floodplains, forests) can offer multiple ecosystem services (ES), including flood resilience and water quality improvement. In order to maintain these ES, state, federal and non-profit organizations may consider various interventions, such as increased floodplain connectivity, reforestation, and wetland restoration to minimize flood peaks and erosion during events. However, the effect of these interventions on hydro-geomorphic responses of streams from reach to catchment scales (>100 km2) are rarely quantified. We used stream geomorphic assessment datasets with a hydraulic model to investigate the influence of above mentioned interventions on stream power (SP), water depth (WD) and channel velocity (VEL) during floods of 2yr and 100yr return periods for three catchments in the Lake Champlain basin, Vermont. To simulate the effect of forests and wetlands, we changed the Manning's coefficient in the model, and to simulate the increased connectivity of the floodplain, we edited the LIDAR data to lower bank elevations. We find that the wetland scenario resulted in the greatest decline in WD and SP, whereas forested scenario exhibited maximum reduction in VEL. The connectivity scenario showed a decline in almost all stream responses, but the magnitude of change was relatively smaller. On average, 35% (2yr) and 50% (100yr) of altered reaches demonstrated improvement over baseline, and 39% (2yr) and 31% (100yr) of altered reaches showed degradation over baseline, across all interventions. We also noted changes in stream response along unaltered reaches (>30%), where we did not make interventions. Overall, these results point to the complexity related to stream interventions and suggest careful evaluation of spatially explicit tradeoffs of these interventions on river-floodplain ecosystem. The proposed approach of simulating and understanding stream's response to interventions, prior to the implementation of restoration activities, may lead to

  19. Positive effects of robotic exoskeleton training of upper limb reaching movements after stroke

    Science.gov (United States)

    2012-01-01

    This study, conducted in a group of nine chronic patients with right-side hemiparesis after stroke, investigated the effects of a robotic-assisted rehabilitation training with an upper limb robotic exoskeleton for the restoration of motor function in spatial reaching movements. The robotic assisted rehabilitation training was administered for a period of 6 weeks including reaching and spatial antigravity movements. To assess the carry-over of the observed improvements in movement during training into improved function, a kinesiologic assessment of the effects of the training was performed by means of motion and dynamic electromyographic analysis of reaching movements performed before and after training. The same kinesiologic measurements were performed in a healthy control group of seven volunteers, to determine a benchmark for the experimental observations in the patients’ group. Moreover degree of functional impairment at the enrolment and discharge was measured by clinical evaluation with upper limb Fugl-Meyer Assessment scale (FMA, 0–66 points), Modified Ashworth scale (MA, 0–60 pts) and active ranges of motion. The robot aided training induced, independently by time of stroke, statistical significant improvements of kinesiologic (movement time, smoothness of motion) and clinical (4.6 ± 4.2 increase in FMA, 3.2 ± 2.1 decrease in MA) parameters, as a result of the increased active ranges of motion and improved co-contraction index for shoulder extension/flexion. Kinesiologic parameters correlated significantly with clinical assessment values, and their changes after the training were affected by the direction of motion (inward vs. outward movement) and position of target to be reached (ipsilateral, central and contralateral peripersonal space). These changes can be explained as a result of the motor recovery induced by the robotic training, in terms of regained ability to execute single joint movements and of improved interjoint coordination of

  20. Positive effects of robotic exoskeleton training of upper limb reaching movements after stroke

    Directory of Open Access Journals (Sweden)

    Frisoli Antonio

    2012-06-01

    Full Text Available Abstract This study, conducted in a group of nine chronic patients with right-side hemiparesis after stroke, investigated the effects of a robotic-assisted rehabilitation training with an upper limb robotic exoskeleton for the restoration of motor function in spatial reaching movements. The robotic assisted rehabilitation training was administered for a period of 6 weeks including reaching and spatial antigravity movements. To assess the carry-over of the observed improvements in movement during training into improved function, a kinesiologic assessment of the effects of the training was performed by means of motion and dynamic electromyographic analysis of reaching movements performed before and after training. The same kinesiologic measurements were performed in a healthy control group of seven volunteers, to determine a benchmark for the experimental observations in the patients’ group. Moreover degree of functional impairment at the enrolment and discharge was measured by clinical evaluation with upper limb Fugl-Meyer Assessment scale (FMA, 0–66 points, Modified Ashworth scale (MA, 0–60 pts and active ranges of motion. The robot aided training induced, independently by time of stroke, statistical significant improvements of kinesiologic (movement time, smoothness of motion and clinical (4.6 ± 4.2 increase in FMA, 3.2 ± 2.1 decrease in MA parameters, as a result of the increased active ranges of motion and improved co-contraction index for shoulder extension/flexion. Kinesiologic parameters correlated significantly with clinical assessment values, and their changes after the training were affected by the direction of motion (inward vs. outward movement and position of target to be reached (ipsilateral, central and contralateral peripersonal space. These changes can be explained as a result of the motor recovery induced by the robotic training, in terms of regained ability to execute single joint movements and of improved

  1. Suspended-sediment trapping in the tidal reach of an estuarine tributary channel

    Science.gov (United States)

    Downing-Kunz, Maureen; Schoellhamer, David H.

    2015-01-01

    Evidence of decreasing sediment supply to estuaries and coastal oceans worldwide illustrates the need for accurate and updated estimates. In the San Francisco Estuary (Estuary), recent research suggests a decrease in supply from its largest tributaries, implying the increasing role of smaller, local tributaries in sediment supply to this estuary. Common techniques for estimating supply from tributaries are based on gages located above head of tide, which do not account for trapping processes within the tidal reach. We investigated the effect of a tidal reach on suspended-sediment discharge for Corte Madera Creek, a small tributary of the Estuary. Discharge of water (Q) and suspended-sediment (SSD) were observed for 3 years at two locations along the creek: upstream of tidal influence and at the mouth. Comparison of upstream and mouth gages showed nearly 50 % trapping of upstream SSD input within the tidal reach over this period. At the storm time scale, suspended-sediment trapping efficiency varied greatly (range −31 to 93 %); storms were classified as low- or high-yield based on upstream SSD. As upstream peak Q increased, high-yield storms exhibited significantly decreased trapping. Tidal conditions at the mouth—ebb duration and peak ebb velocity—during storms had a minor effect on sediment trapping, suggesting fluvial processes dominate. Comparison of characteristic fluvial and tidal discharges at the storm time scale demonstrated longitudinal differences in the regulating process for SSD. These results suggest that SSD from gages situated above head of tide overestimate sediment supply to the open waters beyond tributary mouths and thus trapping processes within the tidal reach should be considered.

  2. Nueva política europea en productos químicos. REACH New European policy on chemical products. REACH

    Directory of Open Access Journals (Sweden)

    Francisco Vargas Marcos

    2005-12-01

    Full Text Available En febrero de 2001, la Comisión Europea publicó el Libro Blanco relativo a la estrategia para la futura política en materia de sustancias y preparados químicos, que se fundamenta en una revisión del sistema comunitario actual de regulación de las sustancias y preparados químicos. Como consecuencia, el 29 de octubre de 2003, la Comisión adoptó la propuesta de Reglamento sobre registro, evaluación, autorización y restricción de las sustancias químicas (REACH. Mediante esta propuesta, además de crearse la Agencia Europea de Sustancias Químicas, se establece el sistema REACH que consta de los siguientes elementos:Registro, que exige a la industria que facilite información sobre sus sustancias con el objeto de conseguir una utilización segura de las mismas.Evaluación, que garantiza que la industria cumple sus obligaciones y evita que se realicen ensayos innecesarios.Autorización de sustancias con propiedades extremadamente preocupantes (CMR, PBT, disruptores endocrinos, etc. para unos usos particulares.Restricción, como red de seguridad para la reducción de riesgos que no hayan sido abordados en las etapas anteriores.Este sistema de recogida de información en varias fases permitirá conocer y reducir los riesgos derivados del uso de unas 30.000 sustancias químicas que se producen/importan en la Unión Europea en cantidad superior a una tonelada/año. La información, una vez validada, se almacenará en una base de datos y podrá utilizarse para el establecimiento de un vínculo causal entre los factores medioambientales y los efectos negativos sobre la salud derivados de la producción y utilización de los productos químicos.In February 2001 the European Commission issued a White Paper on a “Strategy for a future Chemicals Policy” based on a review of the current European Union system for regulating the dangerous substances and preparations. As a result, on 29 October 2003, the Commission endorsed a Proposal for a

  3. Capacitively coupled and direct-current resistivity surveys of selected reaches of Cozad, Thirty-Mile, Orchard-Alfalfa, Kearney, and Outlet Canals in Nebraska, 2012-13

    Science.gov (United States)

    Hobza, Christopher M.; Burton, Bethany L.; Lucius, Jeffrey E.; Tompkins, Ryan E.

    2014-01-01

    Understanding the spatial characteristics of leakage from canals is critical to effectively managing and utilizing water resources for irrigation and hydroelectric purposes. Canal leakage in some parts of Nebraska is the primary source of water for groundwater recharge and helps maintain the base flow of streams. Because surface-water supplies depend on the streamflow of the Platte River and the available water stored in upstream reservoirs, water managers seek to minimize conveyance losses, which can include canal leakage. The U.S. Geological Survey, in cooperation with the Central Platte Natural Resources District and Nebraska Public Power District, used capacitively coupled (CC) and direct-current (DC) resistivity techniques for continuous resistivity profiling to map near-surface lithologies near and underlying the Cozad, Thirty-Mile, Orchard-Alfalfa, Kearney, and Outlet Canals. Approximately 84 kilometers (km) of CC-resistivity data were collected along the five canals. The CC-resistivity data were compared with results from continuous sediment cores and electrical conductivity logs. Generally, the highest resistivities were recorded at the upstream reaches of the Cozad, Thirty-Mile, and Orchard-Alfalfa canals where flood-plain deposits of silt and clay mantle coarser channel deposits of sand and gravel. The finer grained deposits gradually thicken with increasing distance away from the Platte River. Consequently, for many surveyed reaches the thickness of fine-grained deposits exceeded the 8-meter depth of investigation. A detailed geophysical investigation along a 5-km reach of the Outlet Canal southwest of North Platte, Nebraska, used CC and DC resistivity to examine the condition of a compacted-core bank structure and characterized other potential controls on areas of focused seepage. CC-resistivity data, collected along the 5-km study reach, were compared with continuous sediment cores and DC-resistivity data collected near a selected seep near Outlet

  4. [Terrain gradient effect of ecosystem service value in middle reach of Yangtze River, China].

    Science.gov (United States)

    Yang, Suo Hua; Hu, Shou Geng; Qu, Shi Jin

    2018-03-01

    Using land use data in the year 1995, 2005 and 2014, this study estimated the ecosystem service value (ESV) in each county located in the middle reach of Yangtze River and analyzed its spatiotemporal variation features and terrain gradient effects based on "the equivalent value per unit area of ecosystem services in China". The results showed that ESV in the middle reach of Yangtze River was generally higher in mountainous area but lower in plain region, with an obvious terrain gradient effect. Specifically, the relationship of the relief degree of land surface (RDLS) and the ESV showed significant logarithm function at county scale with a high curve fitting degree of 0.53. The ESV increased from 400.35×10 4 yuan·km -2 to 554.57×10 4 yuan·km -2 with the increasing RDLS (grade 1-5) in 2014. During 1995-2004, the ecosystem service value variation changed from decreasing to stable with the increases of the RDLS. With a perspective of ecosystem service values, the value of food production and waste treatment service value decreased with the increase of the RDLS, while the others increased in general, such as the production of raw materials and gas regulation service value, because of the influences of dynamic land use structure in varied topography and distinct dominant ecosystem services from different land types.

  5. Control issues related to bilateral teleoperation of long-reach, flexible manipulators

    International Nuclear Information System (INIS)

    Love, L.J.

    1997-01-01

    A challenging problem presently being addressed by the Department of Energy (DOE) is the extraction of large volumes of hazardous waste from underground waste storage facilities. The nature of the material requires the use of robotic and teleoperated systems. Furthermore, the constraints of the storage tanks require the use of long reach manipulators. These robots are characterized by their large workspace and reduced mass. Unfortunately, this reduction in mass increases structural compliance, making these robots susceptible to vibration. Until recently, no attempt has been made to provide the operator any type of force reflection due to the compliance of the slave robot. This paper addresses the control of bilateral teleoperation systems that use long-reach, flexible manipulators. Analysis and experiments show that the compliance of the slave robot directly affects the stability of the teleoperation system. This study suggests that this may be controlled by increasing the damping on the master robot. However, this increase in target damping increases the energy an operator must exert during the execution of a task. A new teleoperation strategy adapts the target impedance of the master robot to variations in the identified impedance of the remote environment coupled to the slave robot. Experiments show increased performance due to a decrease in the energy the operator must provide during task execution

  6. Medea de Eurípides: la “atétesis” de versos y la construcción gradual de la venganza

    Directory of Open Access Journals (Sweden)

    Pablo A. Cavallero

    2003-12-01

    Full Text Available The work proposes to reexamine the athetesis and the emendations which were applied to diverse passages of Euripides' Medea, asserting that many of these are not necessary, if one understands the revenge as a decision whose method is not established from the beginning, but it is constructed gradually. This gradation provokes apparent contradictions. They are considered the following controverted passages: 40-43, 87, 261-2, 361-2, 366-7, 468, 725-6, 782, 785-6, 923-4, 1056-1080, 1121, 1220-1, 1316, 1359, 1387; and also all the play development, in order to prove the effect of those in the gradual construction of the revenge; it is taken into account the vocabulary use in the inside of the play. In this process, the passages here analysed, and discussed by the critics about his authenticity, result defensible and necessary to establish the graduation, which is verified in the inside structure, in the images and in the construction of the crime.

  7. Selective and persistent deposition and gradual drainage of iodized oil, Lipiodol in the hepatocellular carcinoma after injection into the feeding hepatic artery

    International Nuclear Information System (INIS)

    Okayasu, I.; Hatakeyama, S.; Yoshida, T.; Yoshimatsu, S.; Tsuruta, K.; Miyamoto, H.; Kimula, Y.

    1988-01-01

    The selective and long-term deposition of iodized oil in the hepatocellular carcinoma (HCC) and its gradual drainage were clinicopathologically analyzed in 13 cases. All patients were Japanese and had an intrahepatic arterial injection of Lipiodol (LIP) mixed with Mitomycin C. The comparison among the follow-up computerized tomography (CT) findings, the observation of the soft x-ray radiogram, and histopathologic studies of the surgical or autopsy materials revealed that the selective deposition of LIP in HCC lasted for a long term, particularly in cases treated by LIP combined with transcatheter arterial embolization (TAE). Also revealed was an extremely gradual decrease of LIP from the HCC. It was thus postulated that, mainly, the accumulated macrophages surrounding LIP around the necrotic cancer tissue and, partially, the intrahepatic lymphatic system itself contributed to this drainage. Further, in histologic sections with lipid staining, x-ray microanalysis proved that the lipid droplets in the cancer tissue included highly concentrated iodine, as a deposition of LIP

  8. Treatment Choice for Advanced Non-small Cell Lung Cancer Patients Who Had Gradual Progression After EGFR-TKIs: 32 Cases Report

    Directory of Open Access Journals (Sweden)

    Lin LIN

    2013-10-01

    Full Text Available Background and objective The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs have been widely used in the treatment of the advanced non-small cell lung cancer (NSCLC, especially in the adenocarcinoma patients with activating EGFR mutations. But there is no published overview of the following treatment. This report through observing the efficacy, toxicity and overall survival of different treatments to the advanced NSCLC patients who had gradual progression after EGFR-TKIs, evaluates the influence of the continued treatment and switching chemotherapy. Methods Retrospective review is conducted on 32 cases of advanced NSCLC patients who experienced treatment failure of EGFR-TKIs. One group accepted the continued treatment and the other group accepted the switching chemotherapy. Results The median overall survival of the continued treatment group is 36.0 months. The respose rate of the switching chemotherapy group is 43.75%, and clinical benefit rate (complete and partial response and stable disease is 87.5%. The median overall survival is 15.5 months. The main toxicities are nausea, vomiting and hematological toxicities. Conclusion For the advanced NSCLC patients who had gradual progression after EGFR-TKIs, the continued treatment is one of the acceptable choices.

  9. Price increase

    CERN Multimedia

    2006-01-01

    Please take note that after five years of stable prices at Restaurant No 1 a price increase will come into force on 1st January 2006. This increase has been agreed after discussions between the CSR (Comité de Surveillance des Restaurants) and the catering company Novae and will reflect the inflation rate of the last few years. In addition, a new children's menu will be introduced, as well as 'Max Havelaar' fair-trade coffee at a price of 1.70 CHF.

  10. Price increase

    CERN Multimedia

    2005-01-01

    Please take note that after five years of stable prices at Restaurant No 1 a price increase will come into force on 1st January 2006. This increase has been agreed after discussions between the CSR (Comité de Surveillance des Restaurants) and the catering company Novae and will reflect the inflation rate of the last few years. In addition, a new children's menu will be introduced as well as 'Max Havelaar' fair-trade coffee at a price of 1.70 CHF.

  11. The electromagnetic rocket gun - a means to reach ultrahigh velocities

    International Nuclear Information System (INIS)

    Winterberg, F.

    1983-01-01

    A novel kind of electromagnetic launcher for the acceleration of multigram-size macroparticles, up to velocities required for impact fusion, is proposed. The novel launcher concept combines the efficiency of a gun with the much higher velocities attainable by a rocket. In the proposed concept a rocket-like projectile is launched inside a gun barrel, drawing its energy from a travelling magnetic wave. The travelling magnetic wave heats and ionizes the exhaust jet of the rocket. As a result, the projectile i propelled both by the recoil from the jet and the magnetic pressure of the travelling magnetic wave. In comparison to magnetic linear accelerators, accelerating either superconducting or ferromagnetic projectiles, the proposed concept has several important advantages. First, the exhaust jet is much longer than the rocket-like projectile and which permits a much longer switching time to turn on the travelling magnetic wave. Second, the proposed concept does not require superconducting projectiles, or projectiles made from expensive ferromagnetic material. Third, unlike in railgun accelerators, the projectile can be kept away from the wall, and thereby can reach much larger velocities. (orig.)

  12. Milestone reached for the Big Wheels of the Muon Spectrometer

    CERN Multimedia

    Sandro Palestini

    The assembly and integration of the Big Wheels sectors of the Muon Spectrometer is reaching its conclusion, with only a few sectors of Wheel TGC-A-3 remaining on the assembly stations in building 180. The six trigger chambers (TGCs) wheels and two precision chambers wheels (MDTs) contain in total 104 sectors, which were assembled, equipped with detectors and fully tested over a period of two years. The few remaining Big Wheel sectors still stored in building 180 Most of the sectors left building 180 over the last twelve months, and form the six Wheels currently installed in the ATLAS detector. The remaining two will be installed before the end of the summer. The commitment of the personnel from the many teams who contributed to different parts of the project was essential to its success. In particular, teams coming from countries of different traditions and languages, such as China, Israel, Japan, Pakistan, Russia and USA contributed and collaborated very effectively to the timely completion of the p...

  13. The dipoles reach the half-way mark

    CERN Multimedia

    2006-01-01

    With the positioning of the 616th magnet, installation of the LHC dipoles has reached the half-way mark. Only half the dipoles remain to be installed! The 616th dipole out of a total of 1232 was installed at 3 a.m on Wednesday 12 July. Night and day, the tunnel is the setting for a never-ending series of carefully choreographed installation operations. At a rate of around twenty per week, there has been a steady underground flow of dipole magnets, each measuring 15 metres in length and weighing 34 tonnes. 'In order to recover the accumulated delays, installation is proceeding three times faster than planned', confides Claude Hauviller, who is supervising LHC installation. Four dipoles can be transported underground at the same time. It is a real challenge, which the 65-man team responsible for this difficult task faces on a daily basis. This is because there is very little space in the tunnel and there are no passing places for the magnet transport vehicles. The room for manoeuvre can sometimes be measured ...

  14. East-West European economic integration: Difficult to reach target

    International Nuclear Information System (INIS)

    D'Ermo, V.; Manca, S.

    1993-01-01

    The energy sector of Western Europe is now undergoing a slow growth period due largely to the socio-economic upheavals of East and West German unification and the political-economic restructuring of the countries making up Eastern Europe and the former Soviet Union. This paper evidences this fact by tabling and commenting on 1991-1992 coal, petroleum, natural gas and electric power production/consumption/export statistical data representing energy sector activities in the former COMECON member countries. The poor performance of these countries can be attributed to the effects of energy market liberalization, the restructuring of utility assets, limited production capacities and inflation. It is estimated that the adjustment time to reach economic parity with Western nations will be long but that the waiting period could be shortened through the implementation of technology transfer and financial cooperation programs with the more prosperous countries capable of providing the investment capital and know-how needed for the restructuring of production systems and resource development

  15. Parametric design studies of long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.; March-Leuba, S.; Babcock, S.M.; Burks, B.L.; Hamel, W.R.

    1993-01-01

    A number of different approaches have been studied for remediation of waste storage tanks at various sites. One of the most promising approaches is the use of a high-capacity, long-reach manipulation (LRM) system with a variety of end effectors for dislodging the waste. LRMs may have characteristics significantly different from those of industrial robots due to the long links needed to cover the large workspace. Because link lengths are much greater than their diameters, link flexibility, as well as joint or drive train flexibility, is likely to be significant. LRMs will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, a design approach for determining the kinematic applicability and performance characteristics considering link flexibility is presented with a focus on waste storage tank remediation. This paper addresses key design issues for LRM-based waste retrieval systems. It discusses the effects of parameters such as payload capacity, storage tanks size, and access port diameter on manipulator structural design. The estimated weight, fundamental natural frequency, and static deflection of the manipulator have been calculated for various parameter conditions

  16. Sure start: voices of the 'hard-to-reach'.

    Science.gov (United States)

    Coe, C; Gibson, A; Spencer, N; Stuttaford, M

    2008-07-01

    This research aimed to look in depth at the factors affecting the ability of four Sure Start local programmes, based in a multicultural Midlands city, to engage with 'hard-to-reach' populations. A variety of research strategies and methods were employed. Geographical information systems, participatory research methods and interviews were used in order to understand the extent of the challenge, and hear first hand, why parents may not get involved with Sure Start. The mapping exercise involved collation and mapping of postcode data with respect to boundaries and potential and actual users of Sure Start services. This made possible the identification of any geographical patterning in the distribution of service users and non-users. Participatory research methods were used with parents, enabling them to conduct short interviews within their own communities and make sense of the data collected. Interviews were also conducted with 70 parents across the city, recruited through local schools. The results indicate that parental decisions regarding Sure Start are the product of a complex interaction between numerous factors which may act as either barriers or facilitators to service utilization. The results suggest that a multi-method approach to data collection is useful and appropriate in gaining access to those parents who are non-users of the Sure Start services and enabling their voices to be heard. These findings offer some explanations and insight into the apparent ambivalent attitudes of some families toward Sure Start services. Implications for future practice are discussed.

  17. Real-time well condition monitoring in extended reach wells

    Energy Technology Data Exchange (ETDEWEB)

    Kucs, R.; Spoerker, H.F. [OMV Austria Exploration and Production GmbH, Gaenserndorf (Austria); Thonhauser, G. [Montanuniversitaet Leoben (Austria)

    2008-10-23

    Ever rising daily operating cost for offshore operations make the risk of running into drilling problems due to torque and drag developments in extended reach applications a growing concern. One option to reduce cost related to torque and drag problems can be to monitor torque and drag trends in real time without additional workload on the platform drilling team. To evaluate observed torque or drag trends it is necessary to automatically recognize operations and to have a 'standard value' to compare the measurements to. The presented systematic approach features both options - fully automated operations recognition and real time analysis. Trends can be discussed between rig- and shore-based teams, and decisions can be based on up to date information. Since the system is focused on visualization of real-time torque and drag trends, instead of highly complex and repeated simulations, calculation time is reduced by comparing the real-time rig data against predictions imported from a commercial drilling engineering application. The system allows reacting to emerging stuck pipe situations or developing cuttings beds long before the situations become severe enough to result in substantial lost time. The ability to compare real-time data with historical data from the same or other wells makes the system a valuable tool in supporting a learning organization. The system has been developed in a joint research initiative for field application on the development of an offshore heavy oil field in New Zealand. (orig.)

  18. Muscle synergy extraction during arm reaching movements at different speeds.

    Science.gov (United States)

    Sabzevari, Vahid Reza; Jafari, Amir Homayoun; Boostani, Reza

    2017-01-01

    Muscle synergy is the activation of a group of muscles that contribute to a particular movement. The goal of the present study is to examine the hypothesis that human reaching movements at different speeds share similar muscle synergies and to investigate the kinesiology basis and innervation of muscles. Electromyographic activity from six muscles of the upper limb and shoulder girdle were recorded during three movements at different speeds, i.e. slow, moderate and fast. The effect of window length on the RMS signal of the EMG was analyzed and then EMG envelope signals were decomposed using non-negative matrix factorization. For each of the ten subjects, three synergies were extracted which accounted for at least 99% of the VAF. For each movement, the muscle synergies and muscle activation coefficients of all participants were clustered in to three partitions. Investigation showed a high similarity and dependency of cluster members due to the cosine similarity and mutual information in muscle synergy clustering. For further verification, the EMG envelope signals for all subjects were reconstructed. The results indicated a lower reconstruction error using the center of the muscle synergy clusters in comparison with the average of the activation coefficients, which confirms the current research's hypothesis.

  19. Flow model for open-channel reach or network

    Science.gov (United States)

    Schaffranek, R.W.

    1987-01-01

    Formulation of a one-dimensional model for simulating unsteady flow in a single open-channel reach or in a network of interconnected channels is presented. The model is both general and flexible in that it can be used to simulate a wide range of flow conditions for various channel configurations. It is based on a four-point (box), implicit, finite-difference approximation of the governing nonlinear flow equations with user-definable weighting coefficients to permit varying the solution scheme from box-centered to fully forward. Unique transformation equations are formulated that permit correlation of the unknowns at the extremities of the channels, thereby reducing coefficient matrix and execution time requirements. Discharges and water-surface elevations computed at intermediate locations within a channel are determined following solution of the transformation equations. The matrix of transformation and boundary-condition equations is solved by Gauss elimination using maximum pivot strategy. Two diverse applications of the model are presented to illustrate its broad utility. (USGS)

  20. Reaching for the true overlay in advanced nodes

    Science.gov (United States)

    Koay, Chiew-seng; Hamieh, Bassem; Felix, Nelson; Gaudiello, John

    2017-03-01

    Traditionally, the total measurement uncertainty (TMU) of overlay metrology focuses on dynamic precision, toolinduced-shift, and matching, while rarely examining inaccuracy. However, some researchers have recently shown that measurement inaccuracy can still be large despite optimized small TMU. Moreover, this inaccuracy can consume a significant portion of the overlay budget in the advanced nodes. In addition to qualifying the overlay error of inline wafers, overlay metrology is also used for improving on-product overlay as it provides corrective feedback to the lithography scanner. The accuracy of the correction terms as a result depends directly upon the measurement accuracy. As such, enhanced overlay accuracy will improve the overlay performance of reworked wafers, or subsequently exposed wafers. We have previously shown that a segmented Blossom target is more prone to asymmetry-induced inaccuracy than a nonsegmented target is [1]. Since target segmentation is inevitable for SADP and SAQP patterning processes, their resulting overlay performance leaves a lot to be desired. In our quest to reach for the true overlay, this paper reports our investigations on accuracy enhancement techniques for image-based targets, such as redundancy and self-calibration, and on the use of simulation-optimized scatterometry-based targets.