WorldWideScience

Sample records for governance networks analysing

  1. Evaluating the democratic accountability of governance networks: Analysing two Nordic Megaprojects

    DEFF Research Database (Denmark)

    Aarsæther, Nils; Bjørnå, Hilde; Fotel, Trine

    2009-01-01

    There is currently a need to analyse and measure the democratic accountability of governance networks. This kind of analysis and measurement calls for the development of an interactive conceptualisation of democratic accountability that makes it possible to measure the level of democratic...... accountability of concrete governance networks with reference to the extent to which they interact with (1) relevant politicians appointed through the institutions of representative democracy, (2) the relevant and affected stakeholders, and (3) the wider citizenry. A case study of two governance networks...

  2. Network class superposition analyses.

    Directory of Open Access Journals (Sweden)

    Carl A B Pearson

    Full Text Available Networks are often used to understand a whole system by modeling the interactions among its pieces. Examples include biomolecules in a cell interacting to provide some primary function, or species in an environment forming a stable community. However, these interactions are often unknown; instead, the pieces' dynamic states are known, and network structure must be inferred. Because observed function may be explained by many different networks (e.g., ≈ 10(30 for the yeast cell cycle process, considering dynamics beyond this primary function means picking a single network or suitable sample: measuring over all networks exhibiting the primary function is computationally infeasible. We circumvent that obstacle by calculating the network class ensemble. We represent the ensemble by a stochastic matrix T, which is a transition-by-transition superposition of the system dynamics for each member of the class. We present concrete results for T derived from boolean time series dynamics on networks obeying the Strong Inhibition rule, by applying T to several traditional questions about network dynamics. We show that the distribution of the number of point attractors can be accurately estimated with T. We show how to generate Derrida plots based on T. We show that T-based Shannon entropy outperforms other methods at selecting experiments to further narrow the network structure. We also outline an experimental test of predictions based on T. We motivate all of these results in terms of a popular molecular biology boolean network model for the yeast cell cycle, but the methods and analyses we introduce are general. We conclude with open questions for T, for example, application to other models, computational considerations when scaling up to larger systems, and other potential analyses.

  3. Do Policy Networks lead to Network Governing?

    DEFF Research Database (Denmark)

    Damgaard, Bodil

    This paper challenges the notion that creation of local policy networks necessarily leads to network governing. Through actor-centred case studies in the area of municipally implemented employment policy in Denmark it was found that the local governing mode is determined mainly by the municipality...

  4. Multiple Imputation for Network Analyses

    NARCIS (Netherlands)

    Krause, Robert; Huisman, Mark; Steglich, Christian; Snijders, Thomas

    2016-01-01

    Missing data on network ties is a fundamental problem for network analyses. The biases induced by missing edge data, even when missing completely at random (MCAR), are widely acknowledged and problematic for network analyses (Kossinets, 2006; Huisman & Steglich, 2008; Huisman, 2009). Although

  5. Molecular ecological network analyses

    Directory of Open Access Journals (Sweden)

    Deng Ye

    2012-05-01

    Full Text Available Abstract Background Understanding the interaction among different species within a community and their responses to environmental changes is a central goal in ecology. However, defining the network structure in a microbial community is very challenging due to their extremely high diversity and as-yet uncultivated status. Although recent advance of metagenomic technologies, such as high throughout sequencing and functional gene arrays, provide revolutionary tools for analyzing microbial community structure, it is still difficult to examine network interactions in a microbial community based on high-throughput metagenomics data. Results Here, we describe a novel mathematical and bioinformatics framework to construct ecological association networks named molecular ecological networks (MENs through Random Matrix Theory (RMT-based methods. Compared to other network construction methods, this approach is remarkable in that the network is automatically defined and robust to noise, thus providing excellent solutions to several common issues associated with high-throughput metagenomics data. We applied it to determine the network structure of microbial communities subjected to long-term experimental warming based on pyrosequencing data of 16 S rRNA genes. We showed that the constructed MENs under both warming and unwarming conditions exhibited topological features of scale free, small world and modularity, which were consistent with previously described molecular ecological networks. Eigengene analysis indicated that the eigengenes represented the module profiles relatively well. In consistency with many other studies, several major environmental traits including temperature and soil pH were found to be important in determining network interactions in the microbial communities examined. To facilitate its application by the scientific community, all these methods and statistical tools have been integrated into a comprehensive Molecular Ecological

  6. Good Governance Analysing Performance of Economic Community ...

    African Journals Online (AJOL)

    Good Governance Analysing Performance of Economic Community of West African States and Southern African Development Community Members on Mo Ibrahim Index of ... The Index is important, significant and appropriate because it outlines criteria and conditions deemed essential for Africans to live meaningful lives.

  7. Network architecture as internet governance

    Directory of Open Access Journals (Sweden)

    Francesca Musiani

    2013-10-01

    Full Text Available The architecture of a networked system is its underlying technical and logical structure, including transmission equipment, communication protocols, infrastructure, and connectivity between its components or nodes. This article introduces the idea of network architecture as internet governance, and more specifically, it outlines the dialectic between centralised and distributed architectures, institutions and practices, and how they mutually affect each other. The article argues that network architecture is internet governance in the sense that, by changing the design of the networks subtending internet-based services and the global internet itself, its politics are affected – the balance of rights between users and providers, the capacity of online communities to engage in open and direct interaction, the fair competition between actors of the internet market.

  8. Complexity in governance network theory

    OpenAIRE

    Klijn, Erik-Hans; Koppenjan, Joop

    2014-01-01

    markdownabstractIn this article, we discuss how complexity is viewed in governance network theory. The article provides a systematic elaboration of the notion of complexity, distinguishing three types: substantive, strategic , and institutional complexity. We argue that dealing with these types of complexity in networks is essentially a matter of mutual adaption and cooperation. An important explanation for the occurrence of deadlocks, breakthroughs and outcomes is the presence and the qualit...

  9. Complexity in governance network theory

    NARCIS (Netherlands)

    E-H. Klijn (Erik-Hans); J.F.M. Koppenjan (Joop)

    2014-01-01

    markdownabstractIn this article, we discuss how complexity is viewed in governance network theory. The article provides a systematic elaboration of the notion of complexity, distinguishing three types: substantive, strategic , and institutional complexity. We argue that dealing with these types of

  10. Designing inclusion and exclusion in labour market governance networks

    DEFF Research Database (Denmark)

    Damgaard, Bodil

    networks and do not adequately explain who actually gets access to these networks. Instead I argue that we need to analyse actions taken consciously and deliberately to design inclusion – as well as exclusion – in governance networks, i.e. we need to bring agency into the analysis and analyse...

  11. Network Governance of the Commons

    Directory of Open Access Journals (Sweden)

    Lars Gunnar Carlsson

    2007-11-01

    Full Text Available The survival of the commons is closely associated with the potential to find ways to strengthen contemporary management systems, making them more responsive to a number of complexities, like the dynamics of ecosystems and related, but often fragmented, institutions. A discussion on the desirability of finding ways to establish so-called cross-scale linkages has recently been vitalised in the literature. In the same vein, concepts like adaptive management, co-management and adaptive co-management have been discussed. In essence, these ways of organizing management incorporate an implicit assumption about the establishment of social networks and is more closely related to network governance and social network theory, than to political administrative hierarchy. However, so far, attempts to incorporate social network analysis (SNA in this literature have been rather few, and not particularly elaborate. In this paper, a framework for such an approach will be presented. The framework provides an analytical skeleton for the understanding of joint management and the establishment of cross-scale linkages. The relationships between structural network properties - like density, centrality and heterogeneity - and innovation in adaptive co-management systems are highlighted as important to consider when crafting institutions for natural resource management. The paper makes a theoretical and methodological contribution to the understanding of co-management, and thereby to the survival of the commons.

  12. Measuring the democratic anchorage of governance networks

    DEFF Research Database (Denmark)

    Fotel, Trine; Sørensen, Eva; Torfing, Jacob

    There has been a growing debate about the democratic problems and potentials of governance networks among political scientists and public managers. While some claim that governance networks tend to undermine democracy, others argue that they have the potential to improve and strengthen democracy...... problems and merits of governance networks. This assumption is highly questionable, and prevents a more nuanced assessment of the democratic performance of governance networks. As such, it diverts the focus of attention away from the fact that governance networks may be democratic in some respects...

  13. The European debate on governance networks

    DEFF Research Database (Denmark)

    Sørensen, Eva; Torfing, Jacob

    2014-01-01

    for the emergence of the Europe governance debate are analyzed and the notions of ‘governance’ and ‘governance networks’ are critically examined and defined. A brief assessment of the empirical significance of governance networks at different levels of governing is followed by a presentation and comparison...

  14. Government governance, executive networks and enterprise R&D

    Directory of Open Access Journals (Sweden)

    Xin Jin

    2016-03-01

    Full Text Available The increasingly competitive market environment makes independent innovation the core of the enterprise’s and evens the country’s competitiveness. In order to solve the problem of its own limited R&D resources, firms need to find access to outside resources. Since the government mainly provides policy and financial support, the information diffusion and learning effects of executive networks can effectively compensate for the shortage of formal institutional arrangements. In view of this, we manually collect data on R&D expenditures and executive networks having common management members in China A-share listed companies from 2007 to 2010. Combined with corporate governance and government governance data, this paper empirically tests the influence of government governance and executive networks on enterprise innovation. The empirical results reveal that the governance efficiency of the government where the enterprise is located determines the efficiency of resource allocation firms are faced with, which provides institutional constraints on corporate R&D intensity, and that the establishment and scale of executive networks do contribute to R&D decisions. Further testing shows that compared with non-state-owned enterprises, state-owned enterprises are faced with relatively weaker restraints and pressures in terms of policy, finance, technology and competition. Thus, they show no obvious reliance on government governance quality and the information diffusion of executive networks. The findings of this study help us to understand the role of informal systems in social economics, such as relationship networks and social capital, in the context of China’s economic development, and provide relevant evidence and enrich macro and micro studies of “government and market” and “market and enterprise” relationships.

  15. Metagoverning Collaborative Innovation in Governance Networks

    DEFF Research Database (Denmark)

    Sørensen, Eva; Torfing, Jacob

    2017-01-01

    , the current wave of New Public Governance reforms perceives collaboration between relevant and affected actors from the public and private sector as the primary vehicle of public innovation, and tends to see governance networks as potential arenas for collaborative innovation. The new focus on collaborative...... innovation in networks poses a fundamental challenge for public managers, elected politicians, and others aiming to metagovern governance networks. Hence, we claim that a specific metagovernance strategy is needed when the purpose of governance networks is to stimulate efficiency, effectiveness...

  16. Brokerage and governance for business networks:

    DEFF Research Database (Denmark)

    Gretzinger, Susanne

    2018-01-01

    This paper studies the functioning of network brokers from a governance perspective on inter-firm business networks. As a stylized fact, inter-firm business networks offer benefits to firms, but are at the same time associated with major risks and conflicts that should be managed through adequate...... governance mechanisms. Burt (1992, 2005) proposes that brokers who connect previously isolated or non-collaborating groups of firms can facilitate networking based on opportunities arising from information arbitrage and control over the information flow between different groups of firms within the networks....... We take up the “structural hole” argument and contend that brokers can be an appropriate element of a governance structure for inter-firm business networks. Using a systematic review to connect and interpret the fragmented empirical evidence including in-depth case studies, we establish...

  17. Innovative Governance Strategies in Meetings Destination Networks

    DEFF Research Database (Denmark)

    Gyimóthy, Szilvia; Larson, Mia

    2013-01-01

    and Copenhagen are deeply trusted as legitimate network convenors, their organizational structures and cultures are very dissimilar; which indicates two idealtypical governance approaches to build and sustain a meetings destination network. In Copenhagen the density of the informal social network among network...... and an organizational culture based on consensus, and external efficiency, achieved by an innovative flexible cooperation network adapting to environmental changes. Conceptually, we add new details and aspects to Sheehan et al.’s framework of destination promotion triad.   References D’ Angella, F. & Go, F.M. (2009......Innovative Governance Strategies in Meetings Destination Networks Introduction, problem statement and aims of the study Collaborative regional networks has been long considered as a must in successful tourism development (Dredge & Jenkins 2003) owing to benefits such as scale and scope economics...

  18. The Impact of Metagovernance on Local Governance Networks

    DEFF Research Database (Denmark)

    Damgaard, Bodil; Torfing, Jacob

    2011-01-01

    This article analyses the impact of metagovernance on the functioning of local governance networks. It does so by comparing the functioning of four local governance networks in the field of local employment policy in Denmark. Between 2007 and 2009, two of these networks were linked to jobcentres...... in which the municipality and a state agency shared responsibility for employment policy, while the other two were linked to jobcentres in which the municipality had full responsibility. We explore two types of metagovernance that the local governance networks were subject to: general, hands......-off metagovernance consisting of the assignment of full responsibility to the municipality alone, or of shared responsibility to the municipality and the state jointly; and tailored and fine-tuned metagovernance directed towards only one or a few networks and their corresponding jobcentre(s). Our findings suggest...

  19. Government governance, executive networks and enterprise R&D Expenditure

    OpenAIRE

    Jin, Xin; Lei, Guangyong; Yu, Junli

    2016-01-01

    The increasingly competitive market environment makes independent innovation the core of the enterprise’s and evens the country’s competitiveness. In order to solve the problem of its own limited R&D resources, firms need to find access to outside resources. Since the government mainly provides policy and financial support, the information diffusion and learning effects of executive networks can effectively compensate for the shortage of formal institutional arrangements. In view of this, we ...

  20. Fractal and multifractal analyses of bipartite networks

    Science.gov (United States)

    Liu, Jin-Long; Wang, Jian; Yu, Zu-Guo; Xie, Xian-Hua

    2017-03-01

    Bipartite networks have attracted considerable interest in various fields. Fractality and multifractality of unipartite (classical) networks have been studied in recent years, but there is no work to study these properties of bipartite networks. In this paper, we try to unfold the self-similarity structure of bipartite networks by performing the fractal and multifractal analyses for a variety of real-world bipartite network data sets and models. First, we find the fractality in some bipartite networks, including the CiteULike, Netflix, MovieLens (ml-20m), Delicious data sets and (u, v)-flower model. Meanwhile, we observe the shifted power-law or exponential behavior in other several networks. We then focus on the multifractal properties of bipartite networks. Our results indicate that the multifractality exists in those bipartite networks possessing fractality. To capture the inherent attribute of bipartite network with two types different nodes, we give the different weights for the nodes of different classes, and show the existence of multifractality in these node-weighted bipartite networks. In addition, for the data sets with ratings, we modify the two existing algorithms for fractal and multifractal analyses of edge-weighted unipartite networks to study the self-similarity of the corresponding edge-weighted bipartite networks. The results show that our modified algorithms are feasible and can effectively uncover the self-similarity structure of these edge-weighted bipartite networks and their corresponding node-weighted versions.

  1. Explaining the democratic anchorage of governance networks

    DEFF Research Database (Denmark)

    Skelcher, Chris; Klijn, Erik-Hans; Kübler, Daniel

    2011-01-01

    Advances in understanding the democratic anchorage of governance networks require carefully designed and contextually grounded empirical analysis that take into account contextual factors. The article uses a conjectural framework to study the impact of the national democratic milieu on the relati...

  2. Governance innovation networks for sustainable tuna

    NARCIS (Netherlands)

    Miller, A.M.M.

    2014-01-01

    Governance Innovation Networks for Sustainable Tuna Alice M.M. Miller Tuna fisheries are among the most highly capitalised and valuable fisheries in the world and their exploitation will continue for the foreseeable future. This means the sustainability of tuna stocks is a pressing

  3. Democracy and Governance Networks: Compatible or Not?

    NARCIS (Netherlands)

    E-H. Klijn (Erik-Hans); C. Skelcher (Chris)

    2007-01-01

    textabstractThis paper investigates the relationship between representative democracy and governance networks at a theoretical level. It does so by offering four conjectures and their implications for theory and practice. The incompatibility conjectures rests on the primacy of politics and sees

  4. The future of network governance research

    DEFF Research Database (Denmark)

    Lewis, Jenny

    2011-01-01

    The popularity and scope of network governance research and practice continues to expand from its divergent foundations, assumptions and ethodological positions. This paper introduces a symposium of papers on this substantial sub-field by first summarizing the sprawling research endeavour...

  5. Governance innovation networks for sustainable tuna

    NARCIS (Netherlands)

    Miller, A.M.M.

    2014-01-01

    Governance Innovation Networks for Sustainable Tuna

    Alice M.M. Miller

    Tuna fisheries are among the most highly capitalised and valuable fisheries in the world and their exploitation will continue for the foreseeable future. This means the sustainability of tuna

  6. Network governance of active employment policy

    DEFF Research Database (Denmark)

    Damgaard, Bodil; Torfing, Jacob

    2010-01-01

    The recent reform of the Danish governance system in the field of active employment policy has been subject to fierce criticism, as many commentators fear that it is the beginning of the end of the Danish Model of active stakeholder involvement. Drawing on both quantitative and qualitative data......, this study aims to analyse the impact of the governance reform by assessing the initial experiences with the Local Employment Councils (LECs). The analysis shows that the LECs are relatively well-functioning and contribute to an effective and democratic governance of local employment policy. Furthermore...

  7. Governing Governance : A formal framework for analysing institutional design and enactment governance

    NARCIS (Netherlands)

    King, T.C.

    2016-01-01

    This dissertation is motivated by the need, in today’s globalist world, for a precise way to enable governments, organisations and other regulatory bodies to evaluate the constraints they place on themselves and others. An organisation’s modus operandi is enacting and fulfilling contracts between

  8. Applications of neural network to numerical analyses

    International Nuclear Information System (INIS)

    Takeda, Tatsuoki; Fukuhara, Makoto; Ma, Xiao-Feng; Liaqat, Ali

    1999-01-01

    Applications of a multi-layer neural network to numerical analyses are described. We are mainly concerned with the computed tomography and the solution of differential equations. In both cases as the objective functions for the training process of the neural network we employed residuals of the integral equation or the differential equations. This is different from the conventional neural network training where sum of the squared errors of the output values is adopted as the objective function. For model problems both the methods gave satisfactory results and the methods are considered promising for some kind of problems. (author)

  9. Balancing act: Government roles in an energy conservation network

    NARCIS (Netherlands)

    Peterman, A.; Kourula, A.; Levitt, R.

    2014-01-01

    Government-led interorganizational alliance networks present a sensible opportunity to overcome many societal challenges through collaborative governance. In particular, few researchers have studied alliance networks in the field of energy conservation in commercial buildings—a sector with unique

  10. Gene regulatory networks governing lung specification.

    Science.gov (United States)

    Rankin, Scott A; Zorn, Aaron M

    2014-08-01

    The epithelial lining of the respiratory system originates from a small group of progenitor cells in the ventral foregut endoderm of the early embryo. Research in the last decade has revealed a number of paracrine signaling pathways that are critical for the development of these respiratory progenitors. In the post-genomic era the challenge now is to figure out at the genome wide level how these different signaling pathways and their downstream transcription factors interact in a complex "gene regulatory network" (GRN) to orchestrate early lung development. In this prospective, we review our growing understanding of the GRN governing lung specification. We discuss key gaps in our knowledge and describe emerging opportunities that will soon provide an unprecedented understanding of lung development and accelerate our ability to apply this knowledge to regenerative medicine. © 2014 Wiley Periodicals, Inc.

  11. Trust in governance networks: Its impacts on outcomes

    OpenAIRE

    Klijn, Erik-Hans; Edelenbos, Jurian; Steijn, Bram

    2010-01-01

    markdownabstract__Abstract__ Governance networks are characterized by complex interaction and decision making, and much uncertainty. Surprisingly, there is very little research on the impact of trust in achieving results in governance networks. This article asks two questions: (a) Does trust influence the outcomes of environmental projects? and (b) Does active network management improve the level of trust in networks? The study is based on a Web-based survey of respondents involved in environ...

  12. An examination of a reciprocal relationship between network governance and network structure

    DEFF Research Database (Denmark)

    Bergenholtz, Carsten; Goduscheit, René Chester

    2011-01-01

    In the present article, we examine the network structure and governance of inter-organisational innovation networks over time. Network governance refers to the issue of how to manage and coordinate the relational activities and processes in the network while research on network structure deals wi...

  13. Towards improvisational governance? Jazz improvisation and networked complex governance

    NARCIS (Netherlands)

    M.W. (Martijn) Hartog

    2014-01-01

    In the past decades considerable amounts of power have shifted away from national governments. These shifts have occurred upwards, towards international organisations, sideways due to privatisation and the creation of quasi non-governmental organisations and downwards due to decentralisation of

  14. Exploring the challenges of energy and resources network governance

    International Nuclear Information System (INIS)

    Poocharoen, Ora-orn; Sovacool, Benjamin K.

    2012-01-01

    While a growing amount of literature has recently emerged describing network governance, less attention has been paid to evaluating the actual performance of networks. Our paper looks at the challenges facing network governance for natural resources (primarily logging and forestry) and energy (primarily renewable energy and energy efficiency) in Asia. The paper investigates what network governance is, and what types of challenges networks have to tackle. It then develops a qualitative analytical framework to evaluate the effectiveness of networks consisting of five criteria: (1) clarity of roles and objectives among members, (2) having strong, independent, continual sources of funding, (3) institutional formality (having a permanent secretariat, budget, full time staff, etc.), (4) efficacy (ability to accomplish its mission and goals at the least possible cost); and (5) level of interdependency among members. Finally, we apply this framework to four case studies: the Association of Southeast Asian Nations (ASEAN) Centre for Energy, Renewable Energy and Energy Efficiency Partnership (REEEP), ASEAN Regional Knowledge Network on Forests and Climate Change (FCC), and ASEAN Regional Knowledge Network on Forest Law Enforcement and Governance (FLEG). These cases illustrate effective (or ineffective) environmental and energy networks and the factors that are associated with network governance. - Highlights: ► This article evaluates four cases of energy and resources network governance. ► We assess these cases according to five criteria. ► We illustrate the effectiveness (and ineffectiveness) of these networks.

  15. Network-Based and Binless Frequency Analyses.

    Directory of Open Access Journals (Sweden)

    Sybil Derrible

    Full Text Available We introduce and develop a new network-based and binless methodology to perform frequency analyses and produce histograms. In contrast with traditional frequency analysis techniques that use fixed intervals to bin values, we place a range ±ζ around each individual value in a data set and count the number of values within that range, which allows us to compare every single value of a data set with one another. In essence, the methodology is identical to the construction of a network, where two values are connected if they lie within a given a range (±ζ. The value with the highest degree (i.e., most connections is therefore assimilated to the mode of the distribution. To select an optimal range, we look at the stability of the proportion of nodes in the largest cluster. The methodology is validated by sampling 12 typical distributions, and it is applied to a number of real-world data sets with both spatial and temporal components. The methodology can be applied to any data set and provides a robust means to uncover meaningful patterns and trends. A free python script and a tutorial are also made available to facilitate the application of the method.

  16. Governance and strategy of entrepreneurial networks: an introduction

    NARCIS (Netherlands)

    J. Windsperger (Josef); G.W.J. Hendrikse (George); G. Cliquet (Gérard); T. Ehrmann (Thomas)

    2017-01-01

    textabstractThis special issue focuses on empirical and theoretical papers that help us to better understand the strategy and governance of entrepreneurial networks, such as franchise chains, alliances, and cooperative networks. The following central themes are covered: (I) Which formal governance

  17. Trust in governance networks: Its impacts on outcomes

    NARCIS (Netherlands)

    E-H. Klijn (Erik-Hans); J. Edelenbos (Jurian); A.J. Steijn (Bram)

    2010-01-01

    markdownabstract__Abstract__ Governance networks are characterized by complex interaction and decision making, and much uncertainty. Surprisingly, there is very little research on the impact of trust in achieving results in governance networks. This article asks two questions: (a) Does trust

  18. Local Governance and ICT Research Network for Africa | Page 2 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Local Governance and ICT Research Network for Africa (LOG-IN Africa) is an emergent pan-African network of researchers and research institutions from nine countries. LOG-IN Africa will assess the current state and outcome of electronic local governance initiatives in Africa, focusing on how information and ...

  19. Organizational Network Evolution and Governance Strategies in Megaprojects

    Directory of Open Access Journals (Sweden)

    Yujie Lu

    2015-08-01

    Full Text Available The organization is the key factor for megaprojects in which thousands of connections and relations intertwine and influence the project performance. However, organizational evolution in megaprojects has not been fully studied. This study investigates the evolution of the organizational network of a megaproject in China using social network analysis (SNA, and then proposes corresponding governance strategies. The result shows that megaproject organizations evolve towards more connected networks but are differentiated for various investors. For government invested projects, the organizational network is well connected, cooperative, yet unstable and require strategic long-term governance policies; for private invested projects, the network is stable, but collaboration among participants is low, which indicates a need to establish collaborative governance structures. The result complements the organizational evolution theory for megaprojects and offers effective strategies for governing megaproject organizations. This study also helps practitioners better understand the nature and characteristics of megaproject organizations.

  20. design of government cloud network for a developing economy

    African Journals Online (AJOL)

    In Ondo State, some businesses, telecommunication agencies and government agencies are not utilizing Information Technology (IT) services to its maximum due to challenges faced by IT penetration in the state. This paper presents the design of a Government Cloud (G-Cloud) network for Ondo State Government which ...

  1. Governance of innovation and growth in SME Networks

    DEFF Research Database (Denmark)

    Brink, Tove

    2016-01-01

    The aim of this article is to reveal what organizing of innovation and growth can be enabled in SME networks. This is especially interesting for the governance of loosely coupled networks. The research is conducted in the Danish food industry with three food-producing firm networks. The posed...... hypotheses are tested in a structural equation modelling (SEM) approach with the available data of 60 SMEs. The findings show that the governance of preferred behaviours of SMEs has a considerable significant positive impact on product and systematic innovation, which have a significant impact on growth....... Governance of network connections is also found to have a significant positive impact on growth. The findings contribute to an understanding of how both governance of preferred SME behaviour and network connections enable innovation. This study provides SMEs, SME network organizations and policy bodies...

  2. Computational analyses of synergism in small molecular network motifs.

    Directory of Open Access Journals (Sweden)

    Yili Zhang

    2014-03-01

    Full Text Available Cellular functions and responses to stimuli are controlled by complex regulatory networks that comprise a large diversity of molecular components and their interactions. However, achieving an intuitive understanding of the dynamical properties and responses to stimuli of these networks is hampered by their large scale and complexity. To address this issue, analyses of regulatory networks often focus on reduced models that depict distinct, reoccurring connectivity patterns referred to as motifs. Previous modeling studies have begun to characterize the dynamics of small motifs, and to describe ways in which variations in parameters affect their responses to stimuli. The present study investigates how variations in pairs of parameters affect responses in a series of ten common network motifs, identifying concurrent variations that act synergistically (or antagonistically to alter the responses of the motifs to stimuli. Synergism (or antagonism was quantified using degrees of nonlinear blending and additive synergism. Simulations identified concurrent variations that maximized synergism, and examined the ways in which it was affected by stimulus protocols and the architecture of a motif. Only a subset of architectures exhibited synergism following paired changes in parameters. The approach was then applied to a model describing interlocked feedback loops governing the synthesis of the CREB1 and CREB2 transcription factors. The effects of motifs on synergism for this biologically realistic model were consistent with those for the abstract models of single motifs. These results have implications for the rational design of combination drug therapies with the potential for synergistic interactions.

  3. Governance of occasional multi-sector networks

    NARCIS (Netherlands)

    Treurniet, W.; Logtenberg, R.; Groenewegen, P.

    2014-01-01

    Large-scale safety and security incidents typically require the coordinated effort of multiple organisations. A networked organisation is generally seen as the most appropriate structure for coordination within safety and security collaborations. Such networks generally are mixed-sector networks in

  4. An examination of a reciprocal relationship between network governance and network structure

    DEFF Research Database (Denmark)

    Bergenholtz, Carsten; Goduscheit, René Chester

    structural relations between the actors in the network. These streams of research do contain references to each other but mostly rely on a static conception of the relationship between network structure and the applied network governance. The paper is based on a primarily qualitative case study of a loosely...... coupled Danish inter-organisational innovation network. The proposition is that a reciprocal relation between network governance and network structure can be identified....

  5. Multidirectional Networks of Government Transparency: A Preliminary Model

    Directory of Open Access Journals (Sweden)

    Ahmad Subhan

    2016-11-01

    Full Text Available This article reviews some literature in theoretical level regarding two concepts: governance network and government transparency, in order to search for theoretical linkages and to build an alternative framework that can support the implementation of public disclosure. Transparency agenda has been implemented in various forms at international, national, and local level. Transparency application was also followed by Indonesia with the implementation of Public Information Disclosure Law since 2008. This enthusiasm is quite reasonable because transparency is believed to be one of the human rights principles; as well as a key to better governance, that can help democracy consolidation, prevent corruption, strengthen the legitimacy and improve efficiency. In order to maximize transparency, the government can use a network approach because of some changes at this time, such as democratization, decentralization, and liberalization has placed the government in a position where there is not one actor who manages the state power without stakeholder’s participation. In this context, the government needs to build synergies with other institutions in a reciprocal relationship with all stakeholders. Therefore, adopting the theory of government networks can be one of the strategies to strengthen government transparency. The findings of this article indicate that the government transparency application needs to develop networks in all directions: intragovernmental, intergovernmental and collaborative networks. These three types of network in contrast with the popular belief that government transparency is interpreted only as a procedural activity to outside parties. A preliminary model in this article gives an overview about the arena of government transparency with multi-directional networks more comprehensively.

  6. An examination of a reciprocal relationship between network governance and network structure

    DEFF Research Database (Denmark)

    Bergenholtz, Carsten; Goduscheit, René Chester

    2011-01-01

    with the overall structural relations between the actors in the network. These streams of research do contain references to each other but they mainly rely on a static conception of the relationship between network structure and the applied network governance. Based on a case study of a loosely coupled Danish...... inter-organisational innovation network, the proposition is that a reciprocal relationship between network governance and network structure can be identified. Such a reciprocal relationship involves theoretical and practical implications for how to govern an inter-organisational network....

  7. Adaptive Networks: the Governance for Sustainable Development

    NARCIS (Netherlands)

    S.G. Nooteboom (Sibout)

    2006-01-01

    textabstractIn this book, I reconstruct how policy makers, working together in what I term adaptive networks, have enabled a breakthrough in thinking about sustainable mobility in certain policy circles. I define the conduct of leading actors in these adaptive networks as sustainable change

  8. Facilitating conditions for boundary-spanning behavior in governance networks

    OpenAIRE

    Meerkerk, Ingmar; Edelenbos, Jurian

    2017-01-01

    textabstractThis article examines the impact of two facilitating conditions for boundary-spanning behaviour in urban governance networks. While research on boundary spanning is growing, there is little attention for antecedents. Combining governance network literature on project management and organizational literature on facilitative and servant leadership, we examine two potential conditions: a facilitative project management style and executive support. We conducted survey research among p...

  9. e-Government project strengthens regional network in the Americas ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-06-22

    Jun 22, 2016 ... Building on the IDRC and Organization of American States partnership which established the Network of e-Government Leaders of Latin America and the Caribbean (RED GEALC) in 2003, the joint project Innovations in e-Government in the Americas has strengthened regional capacity to generate and ...

  10. Governing cruise tourism at Bonaire: a networks and flows approach

    NARCIS (Netherlands)

    Bets, van L.K.J.; Lamers, M.A.J.; Tatenhove, van J.P.M.

    2017-01-01

    Conceptual approaches to thoroughly study governance of cruise tourism are lacking in the literature. Relying on Castells’ network society, we analyze how two interconnected flows of cruise ships and passengers are governed by a marine community of users and policy makers. Bonaire is used as a case

  11. THE SOCIAL NETWORK SITES AND THE GOVERNANCE OF THE SUSTAINABLE DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Cristian Moisoiu

    2013-11-01

    Full Text Available The social network sites are becoming more and more complex communities of social dialogue, involving themselves in the governance processes. The stakeholders in different fields are getting engaged to rebuild the institutional capacity and the consensus process. The present paper tries to analyse few mechanisms that enforce online social network sites to play a role in the sustainable development governance. Is there a possibility for these virtual communities to become useful instruments of sustainable development? Do have the social networks the capacity to command and control the economic activity?

  12. Rethinking Local Governance: Hierarchies and Networks in Mexican Cities

    OpenAIRE

    Francisco Porras

    2007-01-01

    In recent years, the literature of governance has  gained relevance in public administration studies.  One of its main contributions has been to propose  that the use of networks in policy processes, instead of hierarchies, has modified our understanding of contemporary government. Governance  literature has been produced mainly in AngloSaxon countries; nevertheless, this article argues  that it has some value as a tool to explain present  dynamisms in Mexican municipalities. Local  networks ...

  13. Governance Mechanisms in Food Community Networks

    NARCIS (Netherlands)

    Pascucci, S.; Lombardi, A.; Cembalo, L.; Dentoni, D.

    2013-01-01

    This paper discusses the concept of the food community network (FCN) and how consumers and farmers organize credence food transactions. The FCN is based on pooling specific resources and using membership-based contracts to assign decision and property rights. It implies an organization based on a

  14. The Framing of Network Neutrality Governance

    DEFF Research Database (Denmark)

    Perry, James

    The neutrality of the internet with regard to applications (e.g. search, social networking, email, to mention only three) has been central to innovation and growth in the knowledge-economy over the past two decades. Until recently, neutrality was built into the internet's design via its core stan...

  15. Corporate governance in a networked age

    NARCIS (Netherlands)

    Vermeulen, Erik

    2015-01-01

    In a networked and digital age, we need to rethink the structure of the modern corporation. In order to survive and grow, corporations must operate with a new set of assumptions and principles in order to remain relevant, competitive, and successful. Consider the growing number of technology startup

  16. Analysing Stagecoach Network Problem Using Dynamic ...

    African Journals Online (AJOL)

    The stagecoach problem is a special type of network analysis problem in which the cities (nodes) are arranged in stages. By such human or natural arrangement, a journey from City 1 in stage 1 to City n in stage n involves visiting only one city in each intermediate stage. The stagecoach problem involves the determination ...

  17. Trans-European transport network and cross-border governance

    DEFF Research Database (Denmark)

    Guasco, Clement Nicolas

    2014-01-01

    This article looks at the implementation of trans-European transport corridors in the EU and the influence it has on governance within EU member-states. It considers the implementation of such a scheme in the context of cross-border cooperation and discusses the system of governance necessary...... for coordinating knowledge, efforts and solutions across several national systems. In order to understand this governance setting, one needs to understand the specific quality of transnational governance in the EU, which is neither purely international nor federally integrated. The transport corridor between Malmö...... and Hamburg is taken as a case for discussion. Cross-border governance is analyzed within a multi-level policy network approach including actors from supranational, national and subnational levels, in order to determine the existence of a policy network across the borders. The main finding is a depiction...

  18. The Australian optometric workforce 2005, analysed by local government areas.

    Science.gov (United States)

    Kiely, Patricia M; Horton, Peregrine; Chakman, Joseph

    2007-03-01

    Previous studies of the Australian optometric workforce have taken a coarse view of the distribution of optometrists, at best comparing concentrations of optometrists in city and country areas and between states and territories. A more discriminating approach recognising the size and variation in population density of the country is necessary for a more realistic insight into the optometric workforce. This study addresses the distribution of optometrists across smaller geographic units, known as local government areas (LGAs). The number of equivalent full-time optometrists in each Australian LGA was determined using data from the Optometrists Association Australia database. Data from the Australian Bureau of Statistics and the Australian national health program (Medicare) were applied to determine the demand for services based on age distributions in LGAs and to calculate the adequacy of the number of optometrists. Optometrists are concentrated in areas of high population with capital city regions and their surrounds well-serviced but with rural and remote LGAs with low populations generally not having optometrists. The highest excesses of optometrists occur in the capital city LGAs of Melbourne, Sydney and Adelaide (64, 60 and 28.4 equivalent full-time optometrists respectively). The highest deficits occur in Casey (Victoria), Lake Macquarie (New South Wales) and Onkaparinga (South Australia), (-16.4, -15.6 and -13.4 equivalent full-time optometrists, respectively). There are substantial variations in the distribution of optometrists across LGAs in Australia but the variation is often a poor indicator of the ease with which people can access optometric services. In metropolitan areas, people may live close to an optometric practice in a neighbouring LGA. In rural areas, an LGA may appear to have an adequate number of optometrists but some residents may be several hours from the nearest optometrist or the optometric service is provided on a part-time basis.

  19. The Framing of Network Neutrality Governance

    DEFF Research Database (Denmark)

    Perry, James

    The neutrality of the internet with regard to applications (e.g. search, social networking, email, to mention only three) has been central to innovation and growth in the knowledge-economy over the past two decades. Until recently, neutrality was built into the internet's design via its core...... standard, Internet Protocol (IP), which rendered obsolete many of the "normal" restrictive business practises deployed by dominant telecoms companies. As both legal scholars and technologists have explained, the engineering "purity" of IP made the internet a platform for development that was truly...... generative: Useful innovations in applications of the internet could take hold easily, and it was difficult – or indeed impossible - for incumbent business interests to disrupt or sabotage them. However, this neutrality is now under threat. New technologies have given incumbent businesses the ability...

  20. Local Governance and ICT Research Network for Africa | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... promote principles of good governance, and encourage public participation and consultation. The African Training and Research Centre in Administration for Development (CAFRAD) will coordinate the network, ensuring effective implementation, a pan-African outlook and high-level dissemination of research results.

  1. Identifying influential directors in the United States corporate governance network.

    Science.gov (United States)

    Huang, Xuqing; Vodenska, Irena; Wang, Fengzhong; Havlin, Shlomo; Stanley, H Eugene

    2011-10-01

    The influence of directors has been one of the most engaging topics recently, but surprisingly little research has been done to quantitatively evaluate the influence and power of directors. We analyze the structure of the US corporate governance network for the 11-year period 1996-2006 based on director data from the Investor Responsibility Research Center director database, and we develop a centrality measure named the influence factor to estimate the influence of directors quantitatively. The US corporate governance network is a network of directors with nodes representing directors and links between two directors representing their service on common company boards. We assume that information flows in the network through information-sharing processes among linked directors. The influence factor assigned to a director is based on the level of information that a director obtains from the entire network. We find that, contrary to commonly accepted belief that directors of large companies, measured by market capitalization, are the most powerful, in some instances, the directors who are influential do not necessarily serve on boards of large companies. By applying our influence factor method to identify the influential people contained in the lists created by popular magazines such as Fortune, Networking World, and Treasury and Risk Management, we find that the influence factor method is consistently either the best or one of the two best methods in identifying powerful people compared to other general centrality measures that are used to denote the significance of a node in complex network theory.

  2. European Healthy Cities come to terms with health network governance.

    Science.gov (United States)

    de Leeuw, Evelyne; Kickbusch, Ilona; Palmer, Nicola; Spanswick, Lucy

    2015-06-01

    A focus on good governance in the WHO European network of Healthy Cities mirrors the WHO Region's strategic emphasis-its member states in the Health 2020 strategy espouse governance for health as key. Healthy Cities adopted governance as a key value and approach to delivering specific health programmes and policies. This article reviews the extent to which they actually introduce and align governance concepts and approaches with their local government commitments. Healthy Cities show that better participation, policy-making and intersectoral action result from an emphasis on governance. This happens across the designated cities and is not limited to a certain class (in terms of population or geographical location) or the time they have been designated. The support of WHO in driving the governance agenda seems important, but no data are available to show that European Healthy Cities are different from other urban environments. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  3. The Influence of Democratic Legitimacy on Outcomes in Governance Networks

    OpenAIRE

    Klijn, Erik-Hans; Edelenbos, Jurian

    2013-01-01

    markdownabstract__Abstract__ Drawing on different theories of democracy, this article distinguishes three dimensions of democratic legitimacy: political accountability, voice, and due deliberation. The article operationalizes each form of democratic legitimacy and then looks at how these various forms influence the outcomes in governance networks. The authors test this with a survey conducted in the first half of 2010 among respondents in environmental projects/water management projects (n = ...

  4. Public Orchestration, Social Networks, and Transnational Environmental Governance

    DEFF Research Database (Denmark)

    Henriksen, Lasse Folke; Ponte, Stefano

    2018-01-01

    This article contributes to current debates on the potential and limitations of transnational environmental governance, addressing in particular the issue of how private and public regulation compete and/or reinforce each other - and with what results. One of the most influential approaches...... to emerge in recent years has been that of "orchestration." But while recent discussions have focused on a narrow interpretation of orchestration as intermediation, we argue that there is analytical traction in studying orchestration as a combination of directive and facilitative tools. We also argue...... that a social network analytical perspective on orchestration can improve our understanding of how governments and international organizations can shape transnational environmental governance. Through a case study of aviation, we provide two contributions to these debates: first, we propose four analytical...

  5. Social Network Analyses and Nutritional Behavior: An Integrated Modeling Approach

    Directory of Open Access Journals (Sweden)

    Alistair McNair Senior

    2016-01-01

    Full Text Available Animals have evolved complex foraging strategies to obtain a nutritionally balanced diet and associated fitness benefits. Recent advances in nutrition research, combining state-space models of nutritional geometry with agent-based models of systems biology, show how nutrient targeted foraging behavior can also influence animal social interactions, ultimately affecting collective dynamics and group structures. Here we demonstrate how social network analyses can be integrated into such a modeling framework and provide a tangible and practical analytical tool to compare experimental results with theory. We illustrate our approach by examining the case of nutritionally mediated dominance hierarchies. First we show how nutritionally explicit agent-based models that simulate the emergence of dominance hierarchies can be used to generate social networks. Importantly the structural properties of our simulated networks bear similarities to dominance networks of real animals (where conflicts are not always directly related to nutrition. Finally, we demonstrate how metrics from social network analyses can be used to predict the fitness of agents in these simulated competitive environments. Our results highlight the potential importance of nutritional mechanisms in shaping dominance interactions in a wide range of social and ecological contexts. Nutrition likely influences social interaction in many species, and yet a theoretical framework for exploring these effects is currently lacking. Combining social network analyses with computational models from nutritional ecology may bridge this divide, representing a pragmatic approach for generating theoretical predictions for nutritional experiments.

  6. Voluntary Standards, Expert Knowledge and the Governance of Sustainability Networks

    DEFF Research Database (Denmark)

    Ponte, Stefano; Cheyns, Emmanuelle

    2013-01-01

    them, to shape standard setting and management to their advantage depends not only on overcoming important structural differences in endowments and access to resources, but also on more subtle games. These include promoting the enrolment of one expert group or kind of expert knowledge over another......-stakeholder initiatives that establish and manage base codes, standards, certifications and labels. As sustainability moves into the mainstream, understanding the governance of these networks is essential because they partly reshape the structure and characteristics of commodity flows. In this article, we examine...... the role of expert knowledge and process management in governing two multi-stakeholder initiatives (the Marine Stewardship Council and the Roundtable for Sustainable Palm Oil) and in shaping their distributional effects. We find that the ability of developing countries, especially small-scale actors within...

  7. Inequality in new global governance arrangements: the North South Divide in city networks for global environmental governance

    NARCIS (Netherlands)

    Bouteligier, S.

    2011-01-01

    Networks are often portrayed as more equal governance arrangements. Their horizontal character easily leads to the assumption that they go beyond traditional divides. Power relations within networks are neglected because the collaborative activities receive the bulk of attention. However, from a

  8. Sensor networks and netcentric perspectives of civil government

    Science.gov (United States)

    Jones, Deirdre R.; Howard, Timothy G.

    2007-09-01

    Observations of weather and climate yield demonstrated societal benefits, and have been officially part of U.S. government activities since Jefferson. Observing sensor networks contribute to real-time warnings of extreme weather, and to long-term analysis of endemic disease. To learn more about netcentric technologies and their role in observing sensor networks, the National Oceanic & Atmospheric Administration (NOAA) National Weather Service (NWS) and the American Institute of Aeronautics and Astronautics (AIAA) organized a seminar that examined System-of-Systems (SOS), Enterprise Architecture (EA) and Internet Protocol version 6 (IPv6) concepts, using two NOAA programs, the Global Earth Observation Integrated Data Environment (GEO-IDE) and the Integrated Ocean Observing System (IOOS), as examples. Further analysis of the seminar material shows the interrelationship of SOS and EA, with the enabling capability of IPv6 and the framework of a Service-Oriented Architecture (SOA), can help NOAA organize sensor systems-of-systems on a global scale in support of the Global Earth Observing System-of-Systems (GEOSS).

  9. Environmental Governance by Transnational Municipal Networks : The Case of Indonesian Cities

    NARCIS (Netherlands)

    Wiharani, Annisa; Holzhacker, Ronald

    2016-01-01

    Global environmental governance has developed a multi-layer of government from the global to the local. Transnational Municipal Networks (TMNs) are a newly emerging form of organization within global environmental governance. The TMNs are an institutional mechanism to enhance how local governments

  10. Rainwater Harvesting and Social Networks: Visualising Interactions for Niche Governance, Resilience and Sustainability

    Directory of Open Access Journals (Sweden)

    Sarah Ward

    2016-11-01

    Full Text Available Visualising interactions across urban water systems to explore transition and change processes requires the development of methods and models at different scales. This paper contributes a model representing the network interactions of rainwater harvesting (RWH infrastructure innovators and other organisations in the UK RWH niche to identify how resilience and sustainability feature within niche governance in practice. The RWH network interaction model was constructed using a modified participatory social network analysis (SNA. The SNA was further analysed through the application of a two-part analytical framework based on niche management and the safe, resilient and sustainable (‘Safe and SuRe’ framework. Weak interactions between some RWH infrastructure innovators and other organisations highlighted reliance on a limited number of persuaders to influence the regime and landscape, which were underrepresented. Features from niche creation and management were exhibited by the RWH network interaction model, though some observed characteristics were not represented. Additional Safe and SuRe features were identified covering diverse innovation, responsivity, no protection, unconverged expectations, primary influencers, polycentric or adaptive governance and multiple learning-types. These features enable RWH infrastructure innovators and other organisations to reflect on improving resilience and sustainability, though further research in other sectors would be useful to verify and validate observation of the seven features.

  11. Sensitivity of surface meteorological analyses to observation networks

    Science.gov (United States)

    Tyndall, Daniel Paul

    A computationally efficient variational analysis system for two-dimensional meteorological fields is developed and described. This analysis approach is most efficient when the number of analysis grid points is much larger than the number of available observations, such as for large domain mesoscale analyses. The analysis system is developed using MATLAB software and can take advantage of multiple processors or processor cores. A version of the analysis system has been exported as a platform independent application (i.e., can be run on Windows, Linux, or Macintosh OS X desktop computers without a MATLAB license) with input/output operations handled by commonly available internet software combined with data archives at the University of Utah. The impact of observation networks on the meteorological analyses is assessed by utilizing a percentile ranking of individual observation sensitivity and impact, which is computed by using the adjoint of the variational surface assimilation system. This methodology is demonstrated using a case study of the analysis from 1400 UTC 27 October 2010 over the entire contiguous United States domain. The sensitivity of this approach to the dependence of the background error covariance on observation density is examined. Observation sensitivity and impact provide insight on the influence of observations from heterogeneous observing networks as well as serve as objective metrics for quality control procedures that may help to identify stations with significant siting, reporting, or representativeness issues.

  12. Government information collections in the networked environment new issues and models

    CERN Document Server

    Cheverie, Joan F

    2013-01-01

    This insightful book explores the challenging issues related to effective access to government information.Amidst all the chaos of today's dynamic information transition period, the only constants related to government information are change and inconsistency, yet with Government Information Collections in the Networked Environment: New Issues and Models, you will defeat the challenging issues and take advantage of the opportunities that networked government information collections have to offer. This valuable book gives you a fresh opportunity to rethink collecting activities and to

  13. Corporate and supply chain network governance of third party logistics service providers: Effects on buyers’ intention to continue the relationship

    Directory of Open Access Journals (Sweden)

    Salih Börteçine Avci

    2017-06-01

    Full Text Available This study focuses on the impact of corporate governance, supply chain network governance and competencies such as sales and logistics competence on buyers’ intention to relationship continuity. A total number of 258 questionnaires were distributed to Turkish manufacturing firms, selected using cross-sectional sampling method from the Istanbul and Edirne Chamber of Commerce and Industry in Turkey. The data of survey was analysed using PLS-SEM model with WARP PLS 5.0 software. Our findings indicate that corporate governance and supply chain network governance seem to have a positive effect on sales competence and logistics competence, and together, they influence buyers’ intention to relationship continuity. In this respect, the outcomes of this study may provide valuable insights for the third-party logistics (3PL literature in terms of buyers’ intention to relationship continuity.

  14. Growth strategies and governance of horizontal business networks: the case of the biggest German cooperative food retail network

    Directory of Open Access Journals (Sweden)

    Douglas Wegner

    2011-08-01

    Full Text Available Several growth strategies may be adopted by cooperative retail networks, but these strategies create dilemmas about how to organize business networks with a large number of participants and the adjustments in the governance system that are necessary to facilitate growth. The article examines the relations between the growth strategies adopted by a horizontal business network and its governance system. We analyze the case of Edeka, a centennial cooperative network, leader in food retail in Germany, showing its growth strategies and implications for the network structure. The case study was based on various secondary data sources and focuses the whole network – and not the networked firms – as the unit of analysis. Results indicate that, in order to grow, the network changed its governance structure and the process of participation of members in decision making, creating a hierarchical structure with professional management. The paper contributes to the discussions on cooperative governance and demonstrates that governance systems are transient and adapt to the network strategies. From a management viewpoint, the results show the effects of the growth strategies adopted by business networks, regarding the role of network managers and entrepreneurs in network management.

  15. Should government support business angel networks? The tale of Danish business angels network

    DEFF Research Database (Denmark)

    Christensen, Jesper Lindgaard

    2011-01-01

    . This article discusses the possible rationale for governments to support BANs and what criteria to apply when evaluating such networks. The article is based on an in-depth observation study of the whole life cycle of a national BAN – the Danish Business Angel Network (DBAN) – and a comparison with a similar......Policies promoting informal venture capital generally and business angel networks (BANs) in particular have gained increased attention in recent years. As a consequence, BANs are now widespread across Europe. However, there continues to be a debate whether BANs should be supported with public money...... whether to provide continuing support to BANs they should evaluate not only their immediate effectiveness but also whether BANs should be considered a part of the general small business support infrastructure....

  16. Complex Regulatory Networks Governing Production of the Glycopeptide A40926

    Directory of Open Access Journals (Sweden)

    Rosa Alduina

    2018-04-01

    Full Text Available Glycopeptides (GPAs are an important class of antibiotics, with vancomycin and teicoplanin being used in the last 40 years as drugs of last resort to treat infections caused by Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus. A few new GPAs have since reached the market. One of them is dalbavancin, a derivative of A40926 produced by the actinomycete Nonomuraea sp. ATCC 39727, recently classified as N. gerenzanensis. This review summarizes what we currently know on the multilevel regulatory processes governing production of the glycopeptide A40926 and the different approaches used to increase antibiotic yields. Some nutrients, e.g., valine, l-glutamine and maltodextrin, and some endogenous proteins, e.g., Dbv3, Dbv4 and RpoBR, have a positive role on A40926 biosynthesis, while other factors, e.g., phosphate, ammonium and Dbv23, have a negative effect. Overall, the results available so far point to a complex regulatory network controlling A40926 in the native producing strain.

  17. Mental health network governance and coordination: comparative analysis across Canadian regions

    Directory of Open Access Journals (Sweden)

    Mary E. Wiktorowicz

    2010-10-01

    Full Text Available Objective: Modes of governance were compared in ten local mental health networks in diverse contexts (rural/urban and regionalized/non-regionalized to clarify the governance processes that foster inter-organizational collaboration and the conditions that support them.Methods: Case studies of ten local mental health networks were developed using qualitative methods of document review, semi-structured interviews and focus groups that incorporated provincial policy, network and organizational levels of analysis.Results: Mental health networks adopted either a corporate structure, mutual adjustment or an alliance governance model. A corporate structure supported by regionalization offered the most direct means for local governance to attain inter-organizational collaboration. The likelihood that networks with an alliance model developed coordination processes depended on the presence of the following conditions: a moderate number of organizations, goal consensus and trust among the organizations, and network-level competencies. In the small and mid-sized urban networks where these conditions were met their alliance realized the inter-organizational collaboration sought. In the large urban and rural networks where these conditions were not met, externally brokered forms of network governance were required to support alliance based models.Discussion: In metropolitan and rural networks with such shared forms of network governance as an alliance or voluntary mutual adjustment, external mediation by a regional or provincial authority was an important lever to foster inter-organizational collaboration.

  18. Compilation and network analyses of cambrian food webs.

    Directory of Open Access Journals (Sweden)

    Jennifer A Dunne

    2008-04-01

    Full Text Available A rich body of empirically grounded theory has developed about food webs--the networks of feeding relationships among species within habitats. However, detailed food-web data and analyses are lacking for ancient ecosystems, largely because of the low resolution of taxa coupled with uncertain and incomplete information about feeding interactions. These impediments appear insurmountable for most fossil assemblages; however, a few assemblages with excellent soft-body preservation across trophic levels are candidates for food-web data compilation and topological analysis. Here we present plausible, detailed food webs for the Chengjiang and Burgess Shale assemblages from the Cambrian Period. Analyses of degree distributions and other structural network properties, including sensitivity analyses of the effects of uncertainty associated with Cambrian diet designations, suggest that these early Paleozoic communities share remarkably similar topology with modern food webs. Observed regularities reflect a systematic dependence of structure on the numbers of taxa and links in a web. Most aspects of Cambrian food-web structure are well-characterized by a simple "niche model," which was developed for modern food webs and takes into account this scale dependence. However, a few aspects of topology differ between the ancient and recent webs: longer path lengths between species and more species in feeding loops in the earlier Chengjiang web, and higher variability in the number of links per species for both Cambrian webs. Our results are relatively insensitive to the exclusion of low-certainty or random links. The many similarities between Cambrian and recent food webs point toward surprisingly strong and enduring constraints on the organization of complex feeding interactions among metazoan species. The few differences could reflect a transition to more strongly integrated and constrained trophic organization within ecosystems following the rapid

  19. Inequality in new global governance arrangements: the North-South divide in transnational municipal networks

    NARCIS (Netherlands)

    Bouteligier, S.

    2013-01-01

    Networks are often portrayed as more equal governance arrangements because of their horizontal character. Power relations within networks are neglected as the collaborative activities receive the bulk of attention. However, from a critical reading of the network and flows literature we know that

  20. Analyses of resource reservation schemes for optical burst switching networks

    Science.gov (United States)

    Solanska, Michaela; Scholtz, Lubomir; Ladanyi, Libor; Mullerova, Jarmila

    2017-12-01

    With growing demands of Internet Protocol services for transmission capacity and speed, the Optical Burst Switching presents the solution for future high-speed optical networks. Optical Burst Switching is a technology for transmitting large amounts of data bursts through a transparent optical switching network. To successfully transmit bursts over OBS network and reach the destination node, resource reservation schemes have to be implemented to allocate resources and configure optical switches for that burst at each node. The one-way resource reservation schemes and the performance evaluation of reservation schemes are presented. The OBS network model is performed using OMNeT++ simulation environment. During the reservation of network resources, the optical cross-connect based on semiconductor optical amplifier is used as the core node. Optical switches based on semiconductor optical amplifiers are a promising technology for high-speed optical communication networks.

  1. Dispersal governs the reorganization of ecological networks under environmental change.

    Science.gov (United States)

    Thompson, Patrick L; Gonzalez, Andrew

    2017-05-08

    Ecological networks, such as food webs, mutualist webs and host-parasite webs, are reorganizing as species abundances and spatial distributions shift in response to environmental change. Current theoretical expectations for how this reorganization will occur are available for competition or for parts of interaction networks, but these may not extend to more complex networks. Here we use metacommunity theory to develop new expectations for how complex networks will reorganize under environmental change, and show that dispersal is crucial for determining the degree to which networks will retain their composition and structure. When dispersal between habitat patches is low, all types of species interactions act as a strong determinant for whether species can colonize suitable habitats. This colonization resistance drives species turnover, which breaks apart current networks and leads to the formation of new networks. However, when dispersal rates are increased, colonists arrive in high abundance in habitats where they are well adapted, so interactions with resident species contribute less to colonization success. Dispersal ensures that species associations are maintained as they shift in space, so networks retain similar composition and structure. The crucial role of dispersal reinforces the need to manage habitat connectivity to sustain species and interaction diversity into the future.

  2. Capacity allocation in wireless communication networks - models and analyses

    NARCIS (Netherlands)

    Litjens, Remco

    2003-01-01

    This monograph has concentrated on capacity allocation in cellular and Wireless Local Area Networks, primarily with a network operator’s perspective. In the introduc- tory chapter, a reference model has been proposed for the extensive suite of capacity allocation mechanisms that can be applied at

  3. Lessons from social network analyses for behavioral medicine.

    Science.gov (United States)

    Rosenquist, James N

    2011-03-01

    This study presents an overview of the rapidly expanding field of social network analysis, with an emphasis placed on work relevant to behavioral health clinicians and researchers. I outline how social network analysis is a distinct empirical methodology within the social sciences that has the potential to deepen our understanding of how mental health and addiction are influenced by social environmental factors. Whereas there have been a number of recent studies in the mental health literature that discuss social influences on mental illness and addiction, and a number of studies looking at how social networks influence health and behaviors, there are still relatively few studies that combine the two. Those that have suggest that mood symptoms as well as alcohol consumption are clustered within, and may travel along, social networks. Social networks appear to have an important influence on a variety of mental health conditions. This avenue of research has the potential to influence both clinical practice and public policy.

  4. Governing networks in the hollow state: contracting out, process management or a combination of the two?

    NARCIS (Netherlands)

    E-H. Klijn (Erik-Hans)

    2010-01-01

    markdownabstract__Abstract__ The hollow state is characterised by governing through networks. In this article, we explore the nature of the hollow state and trace and illustrate three basic uncertainties in the decision making process which create complexity: knowledge uncertainty,

  5. A complex adaptive system approach to failure of public governance networks

    NARCIS (Netherlands)

    Koolma, H.M.

    2013-01-01

    Institutional failure of societal sectors has become a challenging subject of public inquiry since the financial crisis. In this paper these sectors are conceptualized as publicly governed networks of organization executives, supervisory boards, regulatory agencies, and governmental representatives.

  6. Information services in social networked transportation : governance and ITS.

    Science.gov (United States)

    2014-06-01

    The purpose of this research seeks to understand the functions and the benefits of social : networked transportation (SNT), the processes that make SNT possible, and the institutional : innovations needed to facilitate those processes. First, this re...

  7. Analyses of students' activity in the Internet social networks

    Directory of Open Access Journals (Sweden)

    Ermakov V.A.

    2016-09-01

    Full Text Available the article focuses on the empirical study of students' behavior in social networks; the study was conducted by statistical data analysis methods obtained by interviewing students.

  8. Software-Enabled Distributed Network Governance: The PopMedNet Experience.

    Science.gov (United States)

    Davies, Melanie; Erickson, Kyle; Wyner, Zachary; Malenfant, Jessica; Rosen, Rob; Brown, Jeffrey

    2016-01-01

    The expanded availability of electronic health information has led to increased interest in distributed health data research networks. The distributed research network model leaves data with and under the control of the data holder. Data holders, network coordinating centers, and researchers have distinct needs and challenges within this model. The concerns of network stakeholders are addressed in the design and governance models of the PopMedNet software platform. PopMedNet features include distributed querying, customizable workflows, and auditing and search capabilities. Its flexible role-based access control system enables the enforcement of varying governance policies. Four case studies describe how PopMedNet is used to enforce network governance models. Trust is an essential component of a distributed research network and must be built before data partners may be willing to participate further. The complexity of the PopMedNet system must be managed as networks grow and new data, analytic methods, and querying approaches are developed. The PopMedNet software platform supports a variety of network structures, governance models, and research activities through customizable features designed to meet the needs of network stakeholders.

  9. Social network and dominance hierarchy analyses at Chimpanzee Sanctuary Northwest.

    Directory of Open Access Journals (Sweden)

    Jake A Funkhouser

    Full Text Available Different aspects of sociality bear considerable weight on the individual- and group-level welfare of captive nonhuman primates. Social Network Analysis (SNA is a useful tool for gaining a holistic understanding of the dynamic social relationships of captive primate groups. Gaining a greater understanding of captive chimpanzees through investigations of centrality, preferred and avoided relationships, dominance hierarchy, and social network diagrams can be useful in advising current management practices in sanctuaries and other captive settings. In this study, we investigated the dyadic social relationships, group-level social networks, and dominance hierarchy of seven chimpanzees (Pan troglodytes at Chimpanzee Sanctuary Northwest. We used focal-animal and instantaneous scan sampling to collect 106.75 total hours of associative, affiliative, and agonistic data from June to September 2016. We analyzed our data using SOCPROG to derive dominance hierarchies and network statistics, and we diagrammed the group's social networks in NetDraw. Three individuals were most central in the grooming network, while two others had little connection. Through agonistic networks, we found that group members reciprocally exhibited agonism, and the group's dominance hierarchy was statistically non-linear. One chimpanzee emerged as the most dominant through agonism but was least connected to other group members across affiliative networks. Our results indicate that the conventional methods used to calculate individuals' dominance rank may be inadequate to wholly depict a group's social relationships in captive sanctuary populations. Our results have an applied component that can aid sanctuary staff in a variety of ways to best ensure the improvement of group welfare.

  10. Social network and dominance hierarchy analyses at Chimpanzee Sanctuary Northwest.

    Science.gov (United States)

    Funkhouser, Jake A; Mayhew, Jessica A; Mulcahy, John B

    2018-01-01

    Different aspects of sociality bear considerable weight on the individual- and group-level welfare of captive nonhuman primates. Social Network Analysis (SNA) is a useful tool for gaining a holistic understanding of the dynamic social relationships of captive primate groups. Gaining a greater understanding of captive chimpanzees through investigations of centrality, preferred and avoided relationships, dominance hierarchy, and social network diagrams can be useful in advising current management practices in sanctuaries and other captive settings. In this study, we investigated the dyadic social relationships, group-level social networks, and dominance hierarchy of seven chimpanzees (Pan troglodytes) at Chimpanzee Sanctuary Northwest. We used focal-animal and instantaneous scan sampling to collect 106.75 total hours of associative, affiliative, and agonistic data from June to September 2016. We analyzed our data using SOCPROG to derive dominance hierarchies and network statistics, and we diagrammed the group's social networks in NetDraw. Three individuals were most central in the grooming network, while two others had little connection. Through agonistic networks, we found that group members reciprocally exhibited agonism, and the group's dominance hierarchy was statistically non-linear. One chimpanzee emerged as the most dominant through agonism but was least connected to other group members across affiliative networks. Our results indicate that the conventional methods used to calculate individuals' dominance rank may be inadequate to wholly depict a group's social relationships in captive sanctuary populations. Our results have an applied component that can aid sanctuary staff in a variety of ways to best ensure the improvement of group welfare.

  11. Studying citizen-centred implementation networks in the age of governance

    DEFF Research Database (Denmark)

    Jacobi, Claus Brygger

    -autonomous social fields. Besides contributing with a coherent conceptual framework for studying social positions practiced by stakeholders, this approach adds to the investigation and analysis of manifestations of self-governance and co-governance in the citizen-centred implementation networks. Finally...

  12. Governance and Governance Networks in Europe: An Assessment of 10 years of research on the theme

    NARCIS (Netherlands)

    E-H. Klijn (Erik-Hans)

    2008-01-01

    markdownabstract__Abstract__ The term governance has been used in a variety of ways, but is most often presented as an attempt to improve coordination between relatively dependent actors for the purpose of solving societal problems. It involves the horizontal steering of relations across

  13. Community Broadband Networks and the Opportunity for E-Government Services

    DEFF Research Database (Denmark)

    Williams, Idongesit

    2017-01-01

    Community Broadband Networks (CBN) facilitate Broadband connectivity in underserved areas in many countries. The lack of Broadband connectivity is one of the reasons for the slow diffusion of e-government services in many countries.This article explains how CBNs can be enabled by governments...... to facilitate the delivery of e–government services in underserved areas in the developed and developing countries.The Community Based Broadband Mobilization (CBNM) models are used as explanatory tools....

  14. design of government cloud network for a developing economy

    African Journals Online (AJOL)

    user

    Denmark, Finland, Germany, Ireland, Spain and United. Kingdom. France is one of those countries that favour the development and installation of a nation-wide cloud for government called “Andromeda” in 2011 [1]. Meanwhile the objectives of the .... technical (cyber security and infrastructure management) and ethical ...

  15. Building a Governance Strategy for CER: The Patient Outcomes Research to Advance Learning (PORTAL) Network Experience.

    Science.gov (United States)

    Paolino, Andrea R; McGlynn, Elizabeth A; Lieu, Tracy; Nelson, Andrew F; Prausnitz, Stephanie; Horberg, Michael A; Arterburn, David E; Gould, Michael K; Laws, Reesa L; Steiner, John F

    2016-01-01

    The Patient Outcomes Research to Advance Learning (PORTAL) Network was established with funding from the Patient-Centered Outcomes Research Institute (PCORI) in 2014. The PORTAL team adapted governance structures and processes from past research network collaborations. We will review and outline the structures and processes of the PORTAL governance approach and describe how proactively focusing on priority areas helped us to facilitate an ambitious research agenda. For years a variety of funders have supported large-scale infrastructure grants to promote the use of clinical datasets to answer important comparative effectiveness research (CER) questions. These awards have provided the impetus for health care systems to join forces in creating clinical data research networks. Often, these scientific networks do not develop governance processes proactively or systematically, and address issues only as problems arise. Even if network leaders and collaborators foresee the need to develop governance approaches, they may underestimate the time and effort required to develop sound processes. The resulting delays can impede research progress. Because the PORTAL sites had built trust and a foundation of collaboration by participating with one another in past research networks, essential elements of effective governance such as guiding principles, decision making processes, project governance, data governance, and stakeholders in governance were familiar to PORTAL investigators. This trust and familiarity enabled the network to rapidly prioritize areas that required sound governance approaches: responding to new research opportunities, creating a culture of trust and collaboration, conducting individual studies, within the broader network, assigning responsibility and credit to scientific investigators, sharing data while protecting privacy/security, and allocating resources. The PORTAL Governance Document, complete with a Toolkit of Appendices is included for reference and

  16. PTSD symptomics: network analyses in the field of psychotraumatology.

    Science.gov (United States)

    Armour, Cherie; Fried, Eiko I; Olff, Miranda

    2017-01-01

    Recent years have seen increasing attention on posttraumatic stress disorder (PTSD) research. While research has largely focused on the dichotomy between patients diagnosed with mental disorders and healthy controls - in other words, investigations at the level of diagnoses - recent work has focused on psychopathology symptoms. Symptomics research in the area of PTSD has been scarce so far, although several studies have focused on investigating the network structures of PTSD symptoms. The present special issue of EJPT adds to the literature by curating additional PTSD network studies, each looking at a different aspect of PTSD. We hope that this special issue encourages researchers to conceptualize and model PTSD data from a network perspective, which arguably has the potential to inform and improve the efficacy of therapeutic interventions.

  17. Structural Observability and Sensor Node Selection for Complex Networks Governed by Nonlinear Balance Equations

    NARCIS (Netherlands)

    Kawano, Yu; Cao, Ming

    2017-01-01

    We define and then study the structural observability for a class of complex networks whose dynamics are governed by the nonlinear balance equations. Although related notions of observability of such complex networks have been studied before and in particular, necessary conditions have been reported

  18. Evolving ICT and governance in organizational networks: Conceptual and theoretical foundations

    NARCIS (Netherlands)

    Loukis, E; Janssen, M.F.W.H.A.; Dawes, S.; Zheng, L

    2016-01-01

    Both private and public sector organizations tend to participate in networks in order to gain access to knowledge, skills and resources of other organizations and to create synergies to achieve highly demanding and complex goals they cannot attain individually. The governance of these networks has

  19. The research and implementation of a unified identity authentication in e-government network

    Science.gov (United States)

    Feng, Zhou

    Current problem existing in e-government network is that the applications of information system are developed independently by various departments, and each has its own specific set of authentication and access control mechanism. To build a comprehensive information system in favor of sharing and exchanging information, a sound and secure unified e-government authentication system is firstly needed. The paper, combining with practical development of e-government network, carries out a thorough discussion on how to achieve data synchronization between unified authentication system and related application systems.

  20. From Government to Governance: Teach for India and New Networks of Reform in School Education

    Science.gov (United States)

    Subramanian, Vidya K.

    2018-01-01

    The Teach for India (TFI) programme, an important offshoot of the Teach for All/Teach for America global education network, began as a public-private partnership in 2009 in poorly functioning municipal schools in Pune and Mumbai. Like its American counterpart, the programme in India has similar ideas of reform and recruits college graduates and…

  1. Network Governance and the Making of Brazil's Foreign Policy Towards China in the 21st Century

    Directory of Open Access Journals (Sweden)

    Daniel Cardoso

    2016-01-01

    Full Text Available Abstract Driven by China's increasing global influence, China-Brazil relations have deepened significantly in the 21st century; for Brazil, this bilateral relationship has become one of the most important aspects of its foreign relations. This article aims at analysing how Brazil's foreign policy towards China was made and implemented during the eight years of Luiz Inácio Lula da Silva's presidency, and the first four years of Dilma Rousseff's presidency. While scholars agree that the Ministry of Foreign Affairs did not exclusively dominate this policy, little is known about which state and non-state actors were involved, how and why they interacted, and how their interactions influenced policy choices. The article starts by identifying the actors that played a significant role in formulating Brazil's China policy. Next, drawing on the concept of network governance, it explores the processes and mechanisms that governed the interactions among them. It concludes with an assessment of the democratic quality of this policy area.

  2. Governing mobile service innovation in co-evolving value networks

    NARCIS (Netherlands)

    De Reuver, M.

    2009-01-01

    Mobile service innovation requires a broad set of resources and capabilities that are not controlled by one single actor. Equipment manufacturers, operators, content providers and application developers have to work together in so-called value networks in order to develop and offer services to

  3. Analysing Interactions in a Teacher Network Forum: A Sociometric Approach

    Science.gov (United States)

    Lisboa, Eliana Santana; Coutinho, Clara Pereira

    2013-01-01

    This article presents the sociometric analysis of the interactions in a forum of a social network created for the professional development of Portuguese-speaking teachers. The main goal of the forum, which was titled Stricto Sensu, was to discuss the educational value of programmes that joined the distance learning model in Brazil. The empirical…

  4. Power, influence and structure in Natura 2000 governance networks. A comparative analysis of two protected areas in Romania.

    Science.gov (United States)

    Manolache, Steluta; Nita, Andreea; Ciocanea, Cristiana M; Popescu, Viorel D; Rozylowicz, Laurentiu

    2018-04-15

    Successful management of complex social-ecological landscapes overlapping Natura 2000 sites requires collaboration between various actors such as law enforcement agencies, NGOs and enterprises. Natura 2000 governance is stimulated by central actors (e.g., Natura 2000 administrators), with successes and failures of management activities depending on the capacity of the network leader to implement a collaborative approach to environmental governance. By using social network analysis, we analysed the cooperation, information flow and capacity for collective action within Natura 2000 governance networks within two Romanian protected areas: Lower Siret Floodplain and Iron Gates Natural Park. The two networks represent protected areas managed by different types of organisations (i.e., Lower Siret Floodplain - by an NGO, Iron Gates Natural Park - by a public entity). Taking into consideration that NGOs may favour an adaptive co-management, while the public bodies may take a top-down management approach, we hypothesize that Lower Siret Floodplain will have a more cohesive and collaborating network compared to Iron Gates Natural Park, and that there will be a greater representation of private and NGO sector in the network coordinated by Lower Siret Floodplain. Contrary to our expectations, the results show that collaboration patterns are similar in the two networks, although they are governed by two different types of institutions, both being less participative than expected, with low involvement of NGOs and private stakeholders. Furthermore, Lower Siret Floodplain network is surprisingly more centralized around a small number of public authorities, and the pre-existing power of public bodies likely inhibit the capacity of the NGO to collaborate with private stakeholders. We also found lower collaboration levels between actors in the network periphery with other organisations from the same cluster, denoting a clear top-down approach of the management in both networks. Our

  5. Information and Knowledge for Water Governance in the Networked Society

    Directory of Open Access Journals (Sweden)

    Belén Pedregal

    2015-06-01

    Full Text Available In the last few years, parallel evolutionary processes in the socio-political, governmental and technological arenas have been providing new pathways for the collaborative generation, coordination and distribution of polycentric information. From a technological perspective, the proliferation of information and communication technologies (ICTs has boosted the availability of information about our planet, along with its storage, processing and dissemination capabilities. The Worldwide Web and satellite and electronic sensors combined with smart phone technologies have also opened new means for social, political and scientific innovation. From a socio-political standpoint, the implementation of policies that encourage the reutilisation of data and protect the right to information of interested parties, together with growing social demands for transparency, have resulted in an increasing number of governments drawing strategies to open up public data. In this context, this paper addresses two main topics that we deem will be key drivers for improved water governance in the near future. First, it discusses new practices of collaborative and distributed generation and disclosure of information for water governance, and the resulting challenges and opportunities afforded by the use of ICTs. Second, it looks at the interplay between the uptake of ICTs and institutional frameworks, social dynamics and technological structures within which they operate to understand the extent to which ICTs affect decision-making processes and contribute to creating alternative spaces for the production of common services or alternative discourses. Despite the advances in open data policies, findings suggest that there remain significant challenges to take full advantage of the opportunities offered by ICTs, mostly derived from the structural conditions of existing models of decision-making, and information generation and management. It seems that the potentialities of

  6. Governance and Innovation in Industrial Networks: a study of the productive sector of bags and shoes

    Directory of Open Access Journals (Sweden)

    Simone Tiêssa de Jesus Alves

    2014-08-01

    Full Text Available This paper presents a study of the production network configuration determined from the actions of government policies, market players and this innovation in enterprises cluster network. To this end, we applied 21 questionnaires and 26 interviews with network owners of enterprises and organizations support, and made it a documentary research on the history of cluster. Data on types of innovations occurring in companies between 2009 and 2013, and its influence factors were analyzed and categorized by descriptive statistics. The influence of agents in innovations was examined with indicators of social networks. Thus, we proceeded to the analysis and triangulation of data sources to make the case. It was found that the practices of firms are influenced by leading companies in the market. Have the support entities, responsible for the actions of public governance, not assume prominence as the centrality, closeness and intermediation of innovation network.

  7. Phylogenetic trait-based analyses of ecological networks.

    Science.gov (United States)

    Rafferty, Nicole E; Ives, Anthony R

    2013-10-01

    Ecological networks of two interacting guilds of species, such as flowering plants and pollinators, are common in nature, and studying their structure can yield insights into their resilience to environmental disturbances. Here we develop analytical methods for exploring the strengths of interactions within bipartite networks consisting of two guilds of phylogenetically related species. We then apply these methods to investigate the resilience of a plant-pollinator community to anticipated climate change. The methods allow the statistical assessment of, for example, whether closely related pollinators are more likely to visit plants with similar relative frequencies, and whether closely related pollinators tend to visit closely related plants. The methods can also incorporate trait information, allowing us to identify which plant traits are likely responsible for attracting different pollinators. These questions are important for our study of 14 prairie plants and their 22 insect pollinators. Over the last 70 years, six of the plants have advanced their flowering, while eight have not. When we experimentally forced earlier flowering times, five of the six advanced-flowering species experienced higher pollinator visitation rates, whereas only one of the eight other species had more visits; this network thus appears resilient to climate change, because those species with advanced flowering have ample pollinators earlier in the season. Using the methods developed here, we show that advanced-flowering plants did not have a distinct pollinator community from the other eight species. Furthermore, pollinator phylogeny did not explain pollinator community composition; closely related pollinators were not more likely to visit the same plant species. However, differences among pollinator communities visiting different plants were explained by plant height, floral color, and symmetry. As a result, closely related plants attracted similar numbers of pollinators. By parsing out

  8. Hospital networks: how to make them work in Belgium? Facilitators and barriers of different governance models.

    Science.gov (United States)

    De Pourcq, Kaat; De Regge, Melissa; Van den Heede, Koen; Van de Voorde, Carine; Gemmel, Paul; Eeckloo, Kristof

    2018-03-29

    Objectives This study aims to identify the facilitators and barriers to governance models of hospital collaborations. The country-specific characteristics of the Belgian healthcare system and legislation are taken into account. Methods A case study was carried out in six Belgian hospital collaborations. Different types of governance models were selected: two health systems, two participant-governed networks, and two lead-organization-governed networks. Within these collaborations, 43 people were interviewed. Results All structures have both advantages and disadvantages. It is important that the governance model fits the network. However, structural, procedural, and especially contextual factors also affect the collaborations, such as alignment of hospitals' and professionals' goals, competition, distance, level of integrated care, time needed for decision-making, and legal and financial incentives. Conclusion The fit between the governance model and the collaboration can facilitate the functioning of a collaboration. The main barriers we identified are contextual factors. The Belgian government needs to play a major role in facilitating collaboration.

  9. Incorporating alternative design clinical trials in network meta-analyses

    Directory of Open Access Journals (Sweden)

    Thorlund K

    2014-12-01

    Full Text Available Kristian Thorlund,1–3 Eric Druyts,1,4 Kabirraaj Toor,1,5 Jeroen P Jansen,1,6 Edward J Mills1,3 1Redwood Outcomes, Vancouver, BC, 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; 3Stanford Prevention Research Center, Stanford University, Stanford, CA, USA; 4Department of Medicine, Faculty of Medicine, 5School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; 6Department of Public Health and Community Medicine, Tufts University, Boston, MA, USA Introduction: Network meta-analysis (NMA is an extension of conventional pairwise meta-analysis that allows for simultaneous comparison of multiple interventions. Well-established drug class efficacies have become commonplace in many disease areas. Thus, for reasons of ethics and equipoise, it is not practical to randomize patients to placebo or older drug classes. Unique randomized clinical trial designs are an attempt to navigate these obstacles. These alternative designs, however, pose challenges when attempting to incorporate data into NMAs. Using ulcerative colitis as an example, we illustrate an example of a method where data provided by these trials are used to populate treatment networks. Methods: We present the methods used to convert data from the PURSUIT trial into a typical parallel design for inclusion in our NMA. Data were required for three arms: golimumab 100 mg; golimumab 50 mg; and placebo. Golimumab 100 mg induction data were available; however, data regarding those individuals who were nonresponders at induction and those who were responders at maintenance were not reported, and as such, had to be imputed using data from the rerandomization phase. Golimumab 50 mg data regarding responses at week 6 were not available. Existing relationships between the available components were used to impute the expected proportions in this missing subpopulation. Data for placebo maintenance

  10. Polycentrism in Global Health Governance Scholarship Comment on "Four Challenges That Global Health Networks Face".

    Science.gov (United States)

    Tosun, Jale

    2017-05-23

    Drawing on an in-depth analysis of eight global health networks, a recent essay in this journal argued that global health networks face four challenges to their effectiveness: problem definition, positioning, coalition-building, and governance. While sharing the argument of the essay concerned, in this commentary, we argue that these analytical concepts can be used to explicate a concept that has implicitly been used in global health governance scholarship for quite a few years. While already prominent in the discussion of climate change governance, for instance, global health governance scholarship could make progress by looking at global health governance as being polycentric. Concisely, polycentric forms of governance mix scales, mechanisms, and actors. Drawing on the essay, we propose a polycentric approach to the study of global health governance that incorporates coalitionbuilding tactics, internal governance and global political priority as explanatory factors. © 2018 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  11. Analysing and evaluating flood risk governance in the Netherlands: Drowning in safety

    NARCIS (Netherlands)

    Kaufmann, M.; Doorn-Hoekveld, W.J. van; Gilissen, H.K.; Rijswick, H.F.M.W. van

    2016-01-01

    The Netherlands has a long tradition of flood risk management, due to its special physical location in the delta of four major river systems. This low-lying country is historically characterised by a ‘fight against water’. The Flood Risk Governance Arrangement of the Netherlands is characterised by

  12. System Transition. Concepts and Framework for Analysing Nordic Energy System Research and Governance

    Energy Technology Data Exchange (ETDEWEB)

    Koennoelae, T.; Carrillo-Hermosilla, J. (The Centre for Eco-Intelligent Management, IE Business School The Centre for Eco-Intelligent Management, IE Business School, Madrid (Spain)); Have, R. van der (VTT Technical Research Centre of Finland, Espoo (Finland))

    2008-05-15

    System transitions are complex societal co-evolutionary processes that are typically led by gradual adaptation rather than visionary management or coordination. Still, visionary coordination of policies, regulation, corporate strategies and social learning may overcome some barriers and foster new innovation efforts providing sufficient impetus towards system transition. Building on earlier literature and experiences on system transitions and related research and governance, this paper develops an analytical framework. This framework integrates different transitions phases, levels and dimensions and combines them with the governance functions to provide overarching frames for understanding system transitions. While the framework is developed keeping in mind its application in the Nordic energy system transition research and governance, it may also be applicable in other sectors. For the didactic purposes, the paper applies the framework in the analysis of the three energy sector projects by positioning them in the developed framework. Further in-depth analysis of recent and on-going research and governance efforts may provide a good basis to identify relevant synergies and areas for future developments. Moreover, the use of such an overarching transition framework supports the coordination efforts between many sometimes even controversial efforts in the development of energy systems. (orig.)

  13. Network approach for local and community governance of energy: The case of Oxfordshire

    International Nuclear Information System (INIS)

    Parag, Yael; Hamilton, Jo; White, Vicki; Hogan, Bernie

    2013-01-01

    One of the many barriers to the incorporation of local and community actors in emerging energy governance structures and policy delivery mechanisms is the lack of thorough understanding of how they work in practice, and how best to support and develop effective local energy governance. Taking a meso-level perspective and a network approach to governance, this paper sheds some new light on this issue, by focusing on the relation, channels of communication and interactions between low carbon community groups (LCCGs) and other actors. Based on data gathered from LCCGs in Oxfordshire, UK, via network survey and interviews the research maps the relations in terms of the exchanges of information and financial support, and presents a relation-based structure of local energy governance. Analysis reveals the intensity of energy related information exchanges that is taking place at the county level and highlights the centrality of intermediary organization in facilitating information flow. The analysis also identifies actors that are not very dominant in their amount of exchanges, but fill ‘weak-tie’ functions between otherwise disconnected LCCGs or other actors in the network. As an analytical tool the analysis could be useful for various state and non-state actors that want to better understand and support – financially and otherwise – actors that enable energy related local action. - Highlights: • We used social network analysis to examine local and community governance of energy. • We examined information and financial support flow within the network. • Analysis highlights central and peripheral actors in the local governance structure. • The findings highlight the central role intermediary organizations have in local governance structures

  14. Governance by Diffusion: Transnational Municipal Networks and the Spread of Local Climate Strategies in Europe

    OpenAIRE

    Lukas Hakelberg

    2014-01-01

    Cities have become crucial actors for the global governance of climate change. Their increased activity in this field is reflected by the rising number of adoptions of local climate strategies in an original sample of 274 European cities from 1992 to 2009. Using event history analysis, I find that this spread is promoted by transnational municipal networks (TMNs) successfully deploying strategies for governance by diffusion, their impact exceeding that of most alternative explanatory factors ...

  15. Analysing and evaluating flood risk governance in the Netherlands : Drowning in safety?

    OpenAIRE

    Kaufmann, M.; van Doorn - Hoekveld, W.J.; Gilissen, H.K.; van Rijswick, H.F.M.W.

    2016-01-01

    The Netherlands has a long tradition of flood risk management, due to its special physical location in the delta of four major river systems. This low-lying country is historically characterised by a ‘fight against water’. The Flood Risk Governance Arrangement of the Netherlands is characterised by a strong focus on reducing flood probability and governmental responsibility. A key characteristic is the statutory right to flood protection from the state. The arrangement of actors, rules, resou...

  16. Citizen-sensor-networks to confront government decision-makers: Two lessons from the Netherlands.

    Science.gov (United States)

    Carton, Linda; Ache, Peter

    2017-07-01

    This paper presents one emerging social-technical innovation: The evolution of citizen-sensor-networks where citizens organize themselves from the 'bottom up', for the sake of confronting governance officials with measured information about environmental qualities. We have observed how citizen-sensor-networks have been initiated in the Netherlands in cases where official government monitoring and business organizations leave gaps. The formed citizen-sensor-networks collect information about issues that affect the local community in their quality-of-living. In particular, two community initiatives are described where the sensed environmental information, on noise pollution and gas-extraction induced earthquakes respectively, is published through networked geographic information methods. Both community initiatives pioneered in developing an approach that comprises the combined setting-up of sensor data flows, real-time map portals and community organization. Two particular cases are analyzed to trace the emergence and network operation of such 'networked geo-information tools' in practice: (1) The Groningen earthquake monitor, and (2) The Airplane Monitor Schiphol. In both cases, environmental 'externalities' of spatial-economic activities play an important role, having economic dimensions of national importance (e.g. gas extraction and national airport development) while simultaneously affecting the regional community with environmental consequences. The monitoring systems analyzed in this paper are established bottom-up, by citizens for citizens, to serve as 'information power' in dialogue with government institutions. The goal of this paper is to gain insight in how these citizen-sensor-networks come about: how the idea for establishing a sensor network originated, how their value gets recognized and adopted in the overall 'system of governance'; to what extent they bring countervailing power against vested interests and established discourses to the table and

  17. Geo-spatial Service and Application based on National E-government Network Platform and Cloud

    Science.gov (United States)

    Meng, X.; Deng, Y.; Li, H.; Yao, L.; Shi, J.

    2014-04-01

    With the acceleration of China's informatization process, our party and government take a substantive stride in advancing development and application of digital technology, which promotes the evolution of e-government and its informatization. Meanwhile, as a service mode based on innovative resources, cloud computing may connect huge pools together to provide a variety of IT services, and has become one relatively mature technical pattern with further studies and massive practical applications. Based on cloud computing technology and national e-government network platform, "National Natural Resources and Geospatial Database (NRGD)" project integrated and transformed natural resources and geospatial information dispersed in various sectors and regions, established logically unified and physically dispersed fundamental database and developed national integrated information database system supporting main e-government applications. Cross-sector e-government applications and services are realized to provide long-term, stable and standardized natural resources and geospatial fundamental information products and services for national egovernment and public users.

  18. Network meta-analyses performed by contracting companies and commissioned by industry

    NARCIS (Netherlands)

    Schuit, Ewoud; Ioannidis, John P A

    2016-01-01

    Background: Industry commissions contracting companies to perform network meta-analysis for health technology assessment (HTA) and reimbursement submissions. Our objective was to estimate the number of network meta-analyses performed by consulting companies contracted by industry, to assess whether

  19. Citizen-sensor-networks to confront government decision-makers: Two lessons from the Netherlands

    NARCIS (Netherlands)

    Carton, L.J.; Ache, P.M.

    2017-01-01

    This paper presents one emerging social-technical innovation: The evolution of citizen-sensor-networks where citizens organize themselves from the ‘bottom up’, for the sake of confronting governance officials with measured information about environmental qualities. We have observed how

  20. Environmental Certification of Forests: The Evolution of Environmental Governance in a Commodity Network

    Science.gov (United States)

    Klooster, Dan

    2005-01-01

    Non-governmental organizations (NGOs) influence social and environmental aspects of commodity production through certification schemes like organic and forest certification. As these become mainstream, however, they are often compromised by the interests of more powerful agents. Utilizing the concept of governance in global commodity networks,…

  1. Delegation of research governance to networks: research councils as multiple goal boundary organizations

    NARCIS (Netherlands)

    Klerkx, L.W.A.; Leeuwis, C.

    2009-01-01

    The delegation of research governance to networks is increasingly seen as a potential way to resolve the paradox in research fundingi, because it would reduce the direct influence of the state on funding policies, respect the independence of scientific institutions, foster `vigorous¿ scientific

  2. Safety culture and subcontractor network governance in a complex safety critical project

    International Nuclear Information System (INIS)

    Oedewald, Pia; Gotcheva, Nadezhda

    2015-01-01

    In safety critical industries many activities are currently carried out by subcontractor networks. Nevertheless, there are few studies where the core dimensions of resilience would have been studied in safety critical network activities. This paper claims that engineering resilience into a system is largely about steering the development of culture of the system towards better ability to anticipate, monitor, respond and learn. Thus, safety culture literature has relevance in resilience engineering field. This paper analyzes practical and theoretical challenges in applying the concept of safety culture in a complex, dynamic network of subcontractors involved in the construction of a new nuclear power plant in Finland, Olkiluoto 3. The concept of safety culture is in focus since it is widely used in nuclear industry and bridges the scientific and practical interests. This paper approaches subcontractor networks as complex systems. However, the management model of the Olkiluoto 3 project is to a large degree a traditional top-down hierarchy, which creates a mismatch between the management approach and the characteristics of the system to be managed. New insights were drawn from network governance studies. - Highlights: • We studied a relevant topical subject safety culture in nuclear new build project. • We integrated safety science challenges and network governance studies. • We produced practicable insights in managing safety of subcontractor networks

  3. An integer programming formulation to identify the sparse network architecture governing differentiation of embryonic stem cells.

    Science.gov (United States)

    Banerjee, Ipsita; Maiti, Spandan; Parashurama, Natesh; Yarmush, Martin

    2010-05-15

    Primary purpose of modeling gene regulatory networks for developmental process is to reveal pathways governing the cellular differentiation to specific phenotypes. Knowledge of differentiation network will enable generation of desired cell fates by careful alteration of the governing network by adequate manipulation of cellular environment. We have developed a novel integer programming-based approach to reconstruct the underlying regulatory architecture of differentiating embryonic stem cells from discrete temporal gene expression data. The network reconstruction problem is formulated using inherent features of biological networks: (i) that of cascade architecture which enables treatment of the entire complex network as a set of interconnected modules and (ii) that of sparsity of interconnection between the transcription factors. The developed framework is applied to the system of embryonic stem cells differentiating towards pancreatic lineage. Experimentally determined expression profile dynamics of relevant transcription factors serve as the input to the network identification algorithm. The developed formulation accurately captures many of the known regulatory modes involved in pancreatic differentiation. The predictive capacity of the model is tested by simulating an in silico potential pathway of subsequent differentiation. The predicted pathway is experimentally verified by concurrent differentiation experiments. Experimental results agree well with model predictions, thereby illustrating the predictive accuracy of the proposed algorithm. ipb1@pitt.edu Supplementary data are available at Bioinformatics online.

  4. An integer programming formulation to identify the sparse network architecture governing differentiation of embryonic stem cells

    Science.gov (United States)

    Banerjee, Ipsita; Maiti, Spandan; Parashurama, Natesh; Yarmush, Martin

    2010-01-01

    Motivation: Primary purpose of modeling gene regulatory networks for developmental process is to reveal pathways governing the cellular differentiation to specific phenotypes. Knowledge of differentiation network will enable generation of desired cell fates by careful alteration of the governing network by adequate manipulation of cellular environment. Results: We have developed a novel integer programming-based approach to reconstruct the underlying regulatory architecture of differentiating embryonic stem cells from discrete temporal gene expression data. The network reconstruction problem is formulated using inherent features of biological networks: (i) that of cascade architecture which enables treatment of the entire complex network as a set of interconnected modules and (ii) that of sparsity of interconnection between the transcription factors. The developed framework is applied to the system of embryonic stem cells differentiating towards pancreatic lineage. Experimentally determined expression profile dynamics of relevant transcription factors serve as the input to the network identification algorithm. The developed formulation accurately captures many of the known regulatory modes involved in pancreatic differentiation. The predictive capacity of the model is tested by simulating an in silico potential pathway of subsequent differentiation. The predicted pathway is experimentally verified by concurrent differentiation experiments. Experimental results agree well with model predictions, thereby illustrating the predictive accuracy of the proposed algorithm. Contact: ipb1@pitt.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:20363729

  5. Networks and Fault Lines: Understanding the role of housing associations in neighbourhood regeneration: a network governance perspective

    Directory of Open Access Journals (Sweden)

    Gerard van Bortel

    2016-03-01

    Full Text Available The changing role of housing associations in neighbourhood regeneration This study aims to increase our understanding of the role of social housing organisations in neighbourhood regeneration governance networks, in order to enhance the performance and outcomes of these networks. Our understanding of how governance networks work is still limited, especially concerning the role of non-state actors like housing associations. Hierarchical government steering is increasingly mixed with market mechanisms and networked forms of decision-making. These shifts in governance often result in more complex decision-making that can easily lead to deadlocks, low-quality outcomes and ambiguous anchorage of democratic principles. Neighbourhood regeneration takes place in rather exceptional governance networks. The organisations involved, and the problems at hand, are place-based. Actors, like housing associations, local authorities and community organisations, are more or less ‘locked’ into the regeneration network and need to collaborate in order to solve the problems. The complexity of neighbourhood renewal processes is often very high, due to the large number of actors involved, and the combination of insufficient housing quality, lack of affordability and supply, along with social and economic problems that need to be addressed. Housing associations focus on the delivery of affordable decent quality housing; but, in many countries—like the Netherlands and England—these organisations also have an important role in neighbourhood regeneration. Housing associations are non-profit organisations that provide housing for low and moderate-income households. They operate largely autonomously from the government, although they are often strongly regulated and dependent on government subsidies. Housing associations in England and the Netherlands share many organisational characteristics and hybrid third-sector values emerging from the need to balance social and

  6. The network structure of adaptive governance - A single case study of a fish management area

    Directory of Open Access Journals (Sweden)

    Annica Charlotte Sandström

    2009-09-01

    Full Text Available The challenge of establishing adaptive management systems is a widely discussed topic in the literature on natural resource management. Adaptive management essentially focuses on achieving a governance process that is both sensitive to and has the capacity to continuously react to changes within the ecosystem being managed. The adoption of a network approach that perceives governance structures as social networks, searching for the kind of network features promoting this important feature, has been requested by researchers in the field. In particular, the possibilities associated with the application of a formal network approach, using the tools and concepts of social network analysis (SNA, have been identified as having significant potential for advancing this branch of research. This paper aims to address the relation between network structure and adaptability using an empirical approach. With the point of departure in a previously generated theoretical framework as well as related hypotheses, this paper presents a case study of a governance process within a fish management area in Sweden. The hypotheses state that, although higher levels of network density and centralisation promote the rule-forming process, the level of network heterogeneity is important for the existence and spread of ecological knowledge among the actors involved. According to the empirical results, restricted by the single-case study design, this assumption is still a well-working hypothesis. However, in order to advance our knowledge concerning these issues and test the validity of the hypotheses, more empirical work using a similar approach in multiple case study designs is needed.

  7. Dynamics of adolescent friendship networks and smoking behavior : Social network analyses in six European countries

    NARCIS (Netherlands)

    Mercken, Liesbeth; Snijders, Tom A. B.; Steglich, Christian; de Vries, H.

    2009-01-01

    The co-evolution of adolescents' friendship networks and their smoking behavior is examined in a large sample across six European countries. Selection and influence processes are disentangled using new methods of social network analysis that enable alternative selection mechanisms to be controlled

  8. Government-promoted collective research and development in Japan: Analyses of the organization through case studies

    Energy Technology Data Exchange (ETDEWEB)

    Hane, G.J.

    1990-06-01

    A study was commissioned by the Energy Conservation and Utilization Technologies (ECUT) Program of the US Department of Energy (DOE) to better understand the strategies used for cooperative and joint-venture research and development (R D) overseas. The study evaluates the organization and management of several different types of cooperative R D programs in Japan that are sponsored under the Ministry of International Trade and Industry (MITI) Program, Exploratory Research for Advanced Technology (ERATO) Program, and the Key Technology Center (KTC) Program. The ERATO Program grew out of a concern over revising the government's approach to supporting research and technology development. The program was initiated to address what was regarded as a lack of creativity in areas at the forefront of science. The program recruits young researchers and allows them flexibility to explore multi-disciplinary areas at the forefront of science. It has been organized to allow for individual creativity but at the same time to benefit from the combined knowledge of an assembly of researchers. Because the plan is such a radical departure from conventional Japanese philosophy, it has met with certain bureaucratic obstacles. Visits to four ERATO projects are described. The third program, the KTC Program, focuses on getting private firms to venture into risky areas of advanced technology to pave the way for future industries. Its goal is to encourage a shift of resources in the private sector toward areas that are considered essential for the competitive development of future industries. The principal philosophy behind the KTC is that the private sector is in the best position to identify promising technical challenges and to weigh their commercial potential against research uncertainties. Three KTC research joint ventures are briefly described. 13 refs., 9 figs., 35 tabs.

  9. Heath Sector Network Governance and State-building in South Kivu, Democratic Republic of Congo.

    Science.gov (United States)

    Bwimana, Aembe

    2017-12-01

    Longstanding patterns of interaction exist between state and non-state actors seeking to improve public health in Democratic Republic of Congo (DRC). DRC is a weak state, and, in many cases, private actors have stepped in to fill the void created by the lack of state health care provision. However, the role of these interactions in creating a governance network in the health sector has been underexplored. Using data from 18 months of qualitative field research, this study aimed to explore governance networks in DRC's health sector, examining how multiple stakeholders work to manage the health system and how the resulting governance network has been relevant for the state-building process. The findings demonstrate that the health sector in South Kivu is emerging as an arena of networked governance based on active partnerships between state institutions and non-state actors. Interactions between state and non-state actors account for the persistence of the health sector in a setting characterized by state weakness. However, networked governance does not function optimally, because, although non-state interventions fill the void where the state falls short, the DRC state has faced the challenge of interacting with partners with fragmented and horizontally competing agendas. Although weak, the shadow of state authority is present in the arena of stakeholders' interactions, as the state plays a determining role by providing a regulatory framework. Overall, the findings show that the interactive engagement of non-state actors contributes to improving institutional capacity through these actors' engagement with state institutions for health system management and institutional development. However, although networked health sector governance does contribute to state capacity, it is difficult to assess the real influence of these interactions on the state-building process in a context of critical fragility, where coordination and alignment have been problematic. © The

  10. Governance networks as a frame for inter-demoi participation and deliberation

    DEFF Research Database (Denmark)

    Sørensen, Eva

    2012-01-01

    to identify standards for institutional setups that facilitate inter-demoi participation and deliberation. Governance networks represent a part of the challenge posed by the emerging pluricentric system of governance. They may be a central means to cope with the new call for democratic regulation across demoi...... between demoi. The need to find ways to increase the democratic quality of inter-demoi interaction is growing rapidly due to the emergence of a pluricentric political system in which cross-demoi decision-making is more the rule than the exception. There is an urgent call for new theories of democracy able...

  11. Innovation in City Governments

    DEFF Research Database (Denmark)

    Lewis, Jenny M; Ricard, Lykke Margot; Klijn, Erik Hans

    project in Copenhagen, Barcelona and Rotterdam. The book provides major new insights on how structures, networks and leadership in city governments shape the social innovation capacity of cities. It provides ground-breaking analyses of how governance structures and local socio-economic challenges...

  12. How the government's punishment and individual's sensitivity affect the rumor spreading in online social networks

    Science.gov (United States)

    Li, Dandan; Ma, Jing

    2017-03-01

    We explore the impact of punishment of governments and sensitivity of individuals on the rumor spreading in this paper. Considering the facts that some rumors that relate to the hot events could be disseminated repeatedly, however, some other rumors will never be disseminated after they have been popular for some time. Therefore, we investigate two types (SIS and SIR) of rumor spreading models in which the punishment of government and sensitivity of individuals are considered. Based on the mean-field method, we have calculated the spreading threshold of SIS and SIR model, respectively. Furthermore, we perform the rumor spreading process in the Facebook and POK social networks, and achieve that there is an excellent agreement between the theoretical and numerical results of spreading threshold. The results indicate that improving the punishment of government and increasing the sensitivity of individuals could control the spreading of rumor effectively.

  13. Voting behavior, coalitions and government strength through a complex network analysis.

    Science.gov (United States)

    Dal Maso, Carlo; Pompa, Gabriele; Puliga, Michelangelo; Riotta, Gianni; Chessa, Alessandro

    2014-01-01

    We analyze the network of relations between parliament members according to their voting behavior. In particular, we examine the emergent community structure with respect to political coalitions and government alliances. We rely on tools developed in the Complex Network literature to explore the core of these communities and use their topological features to develop new metrics for party polarization, internal coalition cohesiveness and government strength. As a case study, we focus on the Chamber of Deputies of the Italian Parliament, for which we are able to characterize the heterogeneity of the ruling coalition as well as parties specific contributions to the stability of the government over time. We find sharp contrast in the political debate which surprisingly does not imply a relevant structure based on established parties. We take a closer look to changes in the community structure after parties split up and their effect on the position of single deputies within communities. Finally, we introduce a way to track the stability of the government coalition over time that is able to discern the contribution of each member along with the impact of its possible defection. While our case study relies on the Italian parliament, whose relevance has come into the international spotlight in the present economic downturn, the methods developed here are entirely general and can therefore be applied to a multitude of other scenarios.

  14. Analysing efficiency of IPv6 packet transmission over 6LoWPAN network

    Science.gov (United States)

    Kozłowski, Adam; Sosnowski, Janusz

    2017-08-01

    Practical proliferation of Internet of Things (IoT) concept depends upon communication efficiency in the related network. In the paper we outline basic features of wireless communication protocols used in IoT and concentrate on analysing communication overheads. In particular, we discuss the impact of IPv6 packet length on 6LoWPAN network operation with physical and MAC layer defined by IEEE 802.15.4 standard. The presented analysis methodology is useful in estimation of the total goodput (throughput at the application level) and energy consumptions within the whole traffic model which are the crucial features of IoT networks.

  15. Functional enrichment analyses and construction of functional similarity networks with high confidence function prediction by PFP

    Directory of Open Access Journals (Sweden)

    Kihara Daisuke

    2010-05-01

    Full Text Available Abstract Background A new paradigm of biological investigation takes advantage of technologies that produce large high throughput datasets, including genome sequences, interactions of proteins, and gene expression. The ability of biologists to analyze and interpret such data relies on functional annotation of the included proteins, but even in highly characterized organisms many proteins can lack the functional evidence necessary to infer their biological relevance. Results Here we have applied high confidence function predictions from our automated prediction system, PFP, to three genome sequences, Escherichia coli, Saccharomyces cerevisiae, and Plasmodium falciparum (malaria. The number of annotated genes is increased by PFP to over 90% for all of the genomes. Using the large coverage of the function annotation, we introduced the functional similarity networks which represent the functional space of the proteomes. Four different functional similarity networks are constructed for each proteome, one each by considering similarity in a single Gene Ontology (GO category, i.e. Biological Process, Cellular Component, and Molecular Function, and another one by considering overall similarity with the funSim score. The functional similarity networks are shown to have higher modularity than the protein-protein interaction network. Moreover, the funSim score network is distinct from the single GO-score networks by showing a higher clustering degree exponent value and thus has a higher tendency to be hierarchical. In addition, examining function assignments to the protein-protein interaction network and local regions of genomes has identified numerous cases where subnetworks or local regions have functionally coherent proteins. These results will help interpreting interactions of proteins and gene orders in a genome. Several examples of both analyses are highlighted. Conclusion The analyses demonstrate that applying high confidence predictions from PFP

  16. The mental health care model in Brazil: analyses of the funding, governance processes, and mechanisms of assessment

    Directory of Open Access Journals (Sweden)

    Thiago Lavras Trapé

    Full Text Available ABSTRACT OBJECTIVE This study aims to analyze the current status of the mental health care model of the Brazilian Unified Health System, according to its funding, governance processes, and mechanisms of assessment. METHODS We have carried out a documentary analysis of the ordinances, technical reports, conference reports, normative resolutions, and decrees from 2009 to 2014. RESULTS This is a time of consolidation of the psychosocial model, with expansion of the health care network and inversion of the funding for community services with a strong emphasis on the area of crack cocaine and other drugs. Mental health is an underfunded area within the chronically underfunded Brazilian Unified Health System. The governance model constrains the progress of essential services, which creates the need for the incorporation of a process of regionalization of the management. The mechanisms of assessment are not incorporated into the health policy in the bureaucratic field. CONCLUSIONS There is a need to expand the global funding of the area of health, specifically mental health, which has been shown to be a successful policy. The current focus of the policy seems to be archaic in relation to the precepts of the psychosocial model. Mechanisms of assessment need to be expanded.

  17. Dynamics of adolescent friendship networks and smoking behavior: social network analyses in six European countries.

    Science.gov (United States)

    Mercken, Liesbeth; Snijders, Tom A B; Steglich, Christian; de Vries, Hein

    2009-11-01

    The co-evolution of adolescents' friendship networks and their smoking behavior is examined in a large sample across six European countries. Selection and influence processes are disentangled using new methods of social network analysis that enable alternative selection mechanisms to be controlled for. The sample consisted of 7704 adolescents participating in the control group of the ESFA (European Smoking prevention Framework Approach) study. The design was longitudinal with four observations. The main measurements were friendship ties, adolescents smoking behavior, parental smoking behavior, and sibling smoking behavior. Results indicated that in each country adolescents preferred selecting friends based on similar smoking behavior. Support for the influence of friends was found in only two countries. A similarity in smoking behavior between friends was explained more strongly by smoking-based selection processes than by the influence of friends in each of the six countries. Prevention programs need to address aspects that drive peer selection, and reinforce non-smoking attitudes in adolescents.

  18. Analysing human mobility patterns of hiking activities through complex network theory.

    Science.gov (United States)

    Lera, Isaac; Pérez, Toni; Guerrero, Carlos; Eguíluz, Víctor M; Juiz, Carlos

    2017-01-01

    The exploitation of high volume of geolocalized data from social sport tracking applications of outdoor activities can be useful for natural resource planning and to understand the human mobility patterns during leisure activities. This geolocalized data represents the selection of hike activities according to subjective and objective factors such as personal goals, personal abilities, trail conditions or weather conditions. In our approach, human mobility patterns are analysed from trajectories which are generated by hikers. We propose the generation of the trail network identifying special points in the overlap of trajectories. Trail crossings and trailheads define our network and shape topological features. We analyse the trail network of Balearic Islands, as a case of study, using complex weighted network theory. The analysis is divided into the four seasons of the year to observe the impact of weather conditions on the network topology. The number of visited places does not decrease despite the large difference in the number of samples of the two seasons with larger and lower activity. It is in summer season where it is produced the most significant variation in the frequency and localization of activities from inland regions to coastal areas. Finally, we compare our model with other related studies where the network possesses a different purpose. One finding of our approach is the detection of regions with relevant importance where landscape interventions can be applied in function of the communities.

  19. Analysing human mobility patterns of hiking activities through complex network theory.

    Directory of Open Access Journals (Sweden)

    Isaac Lera

    Full Text Available The exploitation of high volume of geolocalized data from social sport tracking applications of outdoor activities can be useful for natural resource planning and to understand the human mobility patterns during leisure activities. This geolocalized data represents the selection of hike activities according to subjective and objective factors such as personal goals, personal abilities, trail conditions or weather conditions. In our approach, human mobility patterns are analysed from trajectories which are generated by hikers. We propose the generation of the trail network identifying special points in the overlap of trajectories. Trail crossings and trailheads define our network and shape topological features. We analyse the trail network of Balearic Islands, as a case of study, using complex weighted network theory. The analysis is divided into the four seasons of the year to observe the impact of weather conditions on the network topology. The number of visited places does not decrease despite the large difference in the number of samples of the two seasons with larger and lower activity. It is in summer season where it is produced the most significant variation in the frequency and localization of activities from inland regions to coastal areas. Finally, we compare our model with other related studies where the network possesses a different purpose. One finding of our approach is the detection of regions with relevant importance where landscape interventions can be applied in function of the communities.

  20. Analysing human mobility patterns of hiking activities through complex network theory

    Science.gov (United States)

    Pérez, Toni; Guerrero, Carlos; Eguíluz, Víctor M.; Juiz, Carlos

    2017-01-01

    The exploitation of high volume of geolocalized data from social sport tracking applications of outdoor activities can be useful for natural resource planning and to understand the human mobility patterns during leisure activities. This geolocalized data represents the selection of hike activities according to subjective and objective factors such as personal goals, personal abilities, trail conditions or weather conditions. In our approach, human mobility patterns are analysed from trajectories which are generated by hikers. We propose the generation of the trail network identifying special points in the overlap of trajectories. Trail crossings and trailheads define our network and shape topological features. We analyse the trail network of Balearic Islands, as a case of study, using complex weighted network theory. The analysis is divided into the four seasons of the year to observe the impact of weather conditions on the network topology. The number of visited places does not decrease despite the large difference in the number of samples of the two seasons with larger and lower activity. It is in summer season where it is produced the most significant variation in the frequency and localization of activities from inland regions to coastal areas. Finally, we compare our model with other related studies where the network possesses a different purpose. One finding of our approach is the detection of regions with relevant importance where landscape interventions can be applied in function of the communities. PMID:28542280

  1. Analyzing networks in industrial ecology – a review of Social-Material Network Analyses

    OpenAIRE

    Schiller, Frank; Penn, Alexandra S.; Basson, Lauren

    2014-01-01

    This review concerns the methodological challenges that industrial ecology faces in integrating natural and social sciences. Network analysis can be seen as the most promising method to mediate between industrial ecology's overall systems approach and the complex structures found in society. It is a well established method across scientific disciplines, including the social sciences. It has been successfully applied in industrial ecology, in which localized phenomena of industrial symbiosis h...

  2. The Continuing Growth of Global Cooperation Networks in Research: A Conundrum for National Governments.

    Directory of Open Access Journals (Sweden)

    Caroline S Wagner

    Full Text Available Global collaboration continues to grow as a share of all scientific cooperation, measured as coauthorships of peer-reviewed, published papers. The percent of all scientific papers that are internationally coauthored has more than doubled in 20 years, and they account for all the growth in output among the scientifically advanced countries. Emerging countries, particularly China, have increased their participation in global science, in part by doubling their spending on R&D; they are increasingly likely to appear as partners on internationally coauthored scientific papers. Given the growth of connections at the international level, it is helpful to examine the phenomenon as a communications network and to consider the network as a new organization on the world stage that adds to and complements national systems. When examined as interconnections across the globe over two decades, a global network has grown denser but not more clustered, meaning there are many more connections but they are not grouping into exclusive 'cliques'. This suggests that power relationships are not reproducing those of the political system. The network has features an open system, attracting productive scientists to participate in international projects. National governments could gain efficiencies and influence by developing policies and strategies designed to maximize network benefits-a model different from those designed for national systems.

  3. Analysing Renewable Energy Source Impacts on Power System National Network Code

    Directory of Open Access Journals (Sweden)

    Georgiana Balaban

    2017-08-01

    Full Text Available This paper analyses the impact on renewable energy sources integrated into the Romanian power system on the electrical network operation considering the reduction of electricity consumption with respect to the 1990s. This decrease has led to increased difficulties in integrating the renewable energy sources into the power system (network reinforcements, as well as issues concerning the balance of production/consumption. Following the excess of certain proportions of the energy mix, intermittent renewable energy sources require the expansion of networks, storage, back-up capacities and efforts for a flexible consumption, in the absence of which renewable energy sources cannot be used or the grid can be overloaded. To highlight the difficulty of connecting some significant capacities installed in wind power plants and photovoltaic installation, the paper presents a case study for Dobrogea area that has the most installed capacity from renewable energy sources in operation.

  4. Cooperative Learning within Educational Networks: Perspectives for Good Educational Governance in Modern Reading Education

    Directory of Open Access Journals (Sweden)

    Gudrun Marci-Boehncke

    2017-10-01

    Full Text Available German schools, universities, and libraries haven’t established a teaching and cooperation practice that uses the potential of a convergent and participatory culture (Jenkins 2006, 2009. Schools and libraries have to collaborate more closely using the digital networks and language of the students of today. Although official references, such as the report of the EU High-Level Group of Experts on Literacy (2012, postulate joint efforts with the objective of promoting reading and media education by different educational and non-educational institutions, at least in Germany this is currently still not a collaborative educational practice. One reason for this might be a missing link in local educational governance. Furthermore, the professional self-image of teachers and librarians, as well as the image of the cooperation partner, may limit effective public cooperation. This contribution starts (1 with an outline of the demands in the field of digital literacy and participatory culture, followed by (2 a discussion about the chances and potentials of partnerships between schools and public libraries, their specific interests, and potential. Finally, (3 problems and principles of good educational governance within those networks are identified and developed to excavate the potential, especially for academic teaching and students’ practice. The article is based on empirical data as well as participatory observation of the three-years teacher training and the seven years of on-the-job-training of librarians of public libraries (“Experten für das Lesen”.

  5. The Governance of Indigenous Natural Products in Namibia: A Policy Network Analysis.

    Science.gov (United States)

    Ndeinoma, Albertina; Wiersum, K Freerk; Arts, Bas

    2018-01-09

    At the end of the 20th century, optimism existed that non-timber forest products (NTFPs) can form an integral part in conservation and development strategies. However, there is limited knowledge on how the different stakeholders could relate to the state or to each other in promoting commercialization of NTFPs. Applying the policy network as an analytical framework, we investigated the structural patterns of actor relations in the governance structure of indigenous natural products (INPs) in Namibia, to understand the implications of such relations on INP policy process. The findings indicate that the INP policy network in Namibia is multi-dimensional, consisting of the Indigenous Plant Task Team (IPTT)-the key governance structure for resource mobilization and information sharing; and functional relations which serve specific roles in the INP value chain. The existing relations have facilitated policy development particularly for heavily regulated species, such as devil's claw; but for other species, only incremental changes are observed in terms of small-scale processing facilities for value addition and exclusive purchase agreements for sustainable sourcing of INPs. Participation of primary producers, private actors and quality standardization bodies is limited in INPs governance structures, which narrow the scope of information sharing. Consequently, despite that the IPTT has fostered publicly funded explorative pilot projects, ranging from production to marketing of INPs, there are no clear guidelines how these projects results can be transferred to private entities for possible commercialization. Further collaboration and information sharing is needed to guide public sector relations with the private entities and cooperatives.

  6. Detection of nonstationary transition to synchronized states of a neural network using recurrence analyses

    Science.gov (United States)

    Budzinski, R. C.; Boaretto, B. R. R.; Prado, T. L.; Lopes, S. R.

    2017-07-01

    We study the stability of asymptotic states displayed by a complex neural network. We focus on the loss of stability of a stationary state of networks using recurrence quantifiers as tools to diagnose local and global stabilities as well as the multistability of a coupled neural network. Numerical simulations of a neural network composed of 1024 neurons in a small-world connection scheme are performed using the model of Braun et al. [Int. J. Bifurcation Chaos 08, 881 (1998), 10.1142/S0218127498000681], which is a modified model from the Hodgkin-Huxley model [J. Phys. 117, 500 (1952)]. To validate the analyses, the results are compared with those produced by Kuramoto's order parameter [Chemical Oscillations, Waves, and Turbulence (Springer-Verlag, Berlin Heidelberg, 1984)]. We show that recurrence tools making use of just integrated signals provided by the networks, such as local field potential (LFP) (LFP signals) or mean field values bring new results on the understanding of neural behavior occurring before the synchronization states. In particular we show the occurrence of different stationary and nonstationarity asymptotic states.

  7. The Sustainability of Global Chain Governance: Network Structures and Local Supplier Upgrading in Thailand

    Directory of Open Access Journals (Sweden)

    Sungchul Cho

    2016-09-01

    Full Text Available Although it has been widely accepted that insertion into global production networks may play a critical role in fostering local supplier upgrading, scholars have yet to fully incorporate heterogeneous configurations of buyer-supplier relationships within networks into empirical testing. Using a representative sample of manufacturing firms in Thailand, we propose a more nuanced empirical framework that asks which features of buyer-supplier relationships are related to which aspects of local supplier upgrading. Our findings, derived from latent class analysis, show that the ways value chains are governed can exert varying effects on different types of technological upgrading. Being a multinational corporation (MNC supplier was found to have positive effects on process and minor product upgrading, irrespective of the types of buyer-supplier networks. However, we found a more radical type of upgrading (i.e., the development of own brands to be negatively related to insertion into ‘quasi-hierarchical’ or ‘buyer-driven relationships’, whilst involvement in ‘cooperative networks’ was associated with a significantly higher tendency of product and brand upgrading. Understanding this inherent relationality provides a crucial balance to previous firm-level findings, suggesting that the sustainability of participation in global value chains depends on the relational structures in which local manufacturers are embedded.

  8. Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses.

    Science.gov (United States)

    Arcas, Aida; Fernández-Capetillo, Oscar; Cases, Ildefonso; Rojas, Ana M

    2014-04-01

    The DNA damage response (DDR) is a crucial signaling network that preserves the integrity of the genome. This network is an ensemble of distinct but often overlapping subnetworks, where different components fulfill distinct functions in precise spatial and temporal scenarios. To understand how these elements have been assembled together in humans, we performed comparative genomic analyses in 47 selected species to trace back their emergence using systematic phylogenetic analyses and estimated gene ages. The emergence of the contribution of posttranslational modifications to the complex regulation of DDR was also investigated. This is the first time a systematic analysis has focused on the evolution of DDR subnetworks as a whole. Our results indicate that a DDR core, mostly constructed around metabolic activities, appeared soon after the emergence of eukaryotes, and that additional regulatory capacities appeared later through complex evolutionary process. Potential key posttranslational modifications were also in place then, with interacting pairs preferentially appearing at the same evolutionary time, although modifications often led to the subsequent acquisition of new targets afterwards. We also found extensive gene loss in essential modules of the regulatory network in fungi, plants, and arthropods, important for their validation as model organisms for DDR studies.

  9. Multivariate Analyses of Phytoplankton Pigment Fluorescence from a Freshwater River Network.

    Science.gov (United States)

    Bhattacharya, Ruchi; Osburn, Christopher L

    2017-06-20

    Monitoring phytoplankton classes in river networks is critical to understanding phytoplankton dynamics and to predicting the ecosystem response to changing land-use and seasons. Applicability of phytoplankton fluorescence as a quick and effective ecological monitoring approach is relatively unexplored in freshwater ecosystems. We used multivariate analyses of fluorescence from pigment extracted in 90% acetone to assess the variability in phytoplankton classes, herbivory, and organic matter quality in a freshwater river network. A total of four models developed by the parallel factor analysis (PARAFAC) of fluorescence excitation and emission matrices identified six components: Model 1 (pheophytin-A and chlorophyll-A), Model 2 (chlorophyll-B and chlorophyll-C), Model 3 (pheophytin-B), and Model 4 (pheophytin-C). Redundancy analyses revealed that in the summer, urban and agricultural streams were abundant in chlorophylls, fresh organic matter, and organic nitrogen, whereas in winter, streams were high in phaeopigments. A slow-moving, light-limited wetland stream was an exception as high phaeopigment abundance was observed in both seasons. The PARAFAC components were used to develop a partial least-squares regression-based model (r 2 = 0.53; Nash-Sutcliffe efficiency = 0.5; n = 147) that successfully predicted chlorophyll-A concentrations from an external subset of river water samples (r 2 = 0.41; p phytoplankton dynamics in large river networks.

  10. Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses

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    Lionikas Arimantas

    2012-11-01

    Full Text Available Abstract Background We have recently identified a number of Quantitative Trait Loci (QTL contributing to the 2-fold muscle weight difference between the LG/J and SM/J mouse strains and refined their confidence intervals. To facilitate nomination of the candidate genes responsible for these differences we examined the transcriptome of the tibialis anterior (TA muscle of each strain by RNA-Seq. Results 13,726 genes were expressed in mouse skeletal muscle. Intersection of a set of 1061 differentially expressed transcripts with a mouse muscle Bayesian Network identified a coherent set of differentially expressed genes that we term the LG/J and SM/J Regulatory Network (LSRN. The integration of the QTL, transcriptome and the network analyses identified eight key drivers of the LSRN (Kdr, Plbd1, Mgp, Fah, Prss23, 2310014F06Rik, Grtp1, Stk10 residing within five QTL regions, which were either polymorphic or differentially expressed between the two strains and are strong candidates for quantitative trait genes (QTGs underlying muscle mass. The insight gained from network analysis including the ability to make testable predictions is illustrated by annotating the LSRN with knowledge-based signatures and showing that the SM/J state of the network corresponds to a more oxidative state. We validated this prediction by NADH tetrazolium reductase staining in the TA muscle revealing higher oxidative potential of the SM/J compared to the LG/J strain (p Conclusion Thus, integration of fine resolution QTL mapping, RNA-Seq transcriptome information and mouse muscle Bayesian Network analysis provides a novel and unbiased strategy for nomination of muscle QTGs.

  11. Resilience to climate change in a cross-scale tourism governance context: a combined quantitative-qualitative network analysis

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    Tobias Luthe

    2016-03-01

    Full Text Available Social systems in mountain regions are exposed to a number of disturbances, such as climate change. Calls for conceptual and practical approaches on how to address climate change have been taken up in the literature. The resilience concept as a comprehensive theory-driven approach to address climate change has only recently increased in importance. Limited research has been undertaken concerning tourism and resilience from a network governance point of view. We analyze tourism supply chain networks with regard to resilience to climate change at the municipal governance scale of three Alpine villages. We compare these with a planned destination management organization (DMO as a governance entity of the same three municipalities on the regional scale. Network measures are analyzed via a quantitative social network analysis (SNA focusing on resilience from a tourism governance point of view. Results indicate higher resilience of the regional DMO because of a more flexible and diverse governance structure, more centralized steering of fast collective action, and improved innovative capacity, because of higher modularity and better core-periphery integration. Interpretations of quantitative results have been qualitatively validated by interviews and a workshop. We conclude that adaptation of tourism-dependent municipalities to gradual climate change should be dealt with at a regional governance scale and adaptation to sudden changes at a municipal scale. Overall, DMO building at a regional scale may enhance the resilience of tourism destinations, if the municipalities are well integrated.

  12. Information technology as a facilitator of suppliers’ collaborative communication, network governance and relationship longevity in supply chains

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    Richard Chinomona

    2013-08-01

    Full Text Available There is an increasing awareness about the paramount importance of information technology within business in the context of large businesses. However, research about the investigation of the role of information technology resources in fostering collaborative communication, network governance and relationship longevity in the small and medium enterprise sector has remained scant. The primary objective of this study was to investigate the influence of information technology on collaborative communication, network governance and relationship longevity in Zimbabwe’s SME sector. Five research hypotheses were posited and sample data from 162 small and medium enterprise suppliers were collected and used to empirically test the hypotheses. The results of this study showed that information technology resources positively influenced small and medium enterprise suppliers’ collaborative communication, network governance and consequential relationship longevity with their buyers in a significant way. Overall, the current study findings provided tentative support to the proposition that information technology resources, collaborative communication and network governance should be recognised as significant antecedents for improved relationship longevity between suppliers and their buyers in the SME setting. Therefore, managers in the small and medium enterprise sector and small and medium enterprise owners need to pay attention to both collaborative communication and network governance in order to optimise information technology resource impact on their relationship longevity with their business counterparts. Limitations and future research directions were also indicated.

  13. Time-Series Analyses of Transcriptomes and Proteomes Reveal Molecular Networks Underlying Oil Accumulation in Canola.

    Science.gov (United States)

    Wan, Huafang; Cui, Yixin; Ding, Yijuan; Mei, Jiaqin; Dong, Hongli; Zhang, Wenxin; Wu, Shiqi; Liang, Ying; Zhang, Chunyu; Li, Jiana; Xiong, Qing; Qian, Wei

    2016-01-01

    Understanding the regulation of lipid metabolism is vital for genetic engineering of canola ( Brassica napus L.) to increase oil yield or modify oil composition. We conducted time-series analyses of transcriptomes and proteomes to uncover the molecular networks associated with oil accumulation and dynamic changes in these networks in canola. The expression levels of genes and proteins were measured at 2, 4, 6, and 8 weeks after pollination (WAP). Our results show that the biosynthesis of fatty acids is a dominant cellular process from 2 to 6 WAP, while the degradation mainly happens after 6 WAP. We found that genes in almost every node of fatty acid synthesis pathway were significantly up-regulated during oil accumulation. Moreover, significant expression changes of two genes, acetyl-CoA carboxylase and acyl-ACP desaturase, were detected on both transcriptomic and proteomic levels. We confirmed the temporal expression patterns revealed by the transcriptomic analyses using quantitative real-time PCR experiments. The gene set association analysis show that the biosynthesis of fatty acids and unsaturated fatty acids are the most significant biological processes from 2-4 WAP and 4-6 WAP, respectively, which is consistent with the results of time-series analyses. These results not only provide insight into the mechanisms underlying lipid metabolism, but also reveal novel candidate genes that are worth further investigation for their values in the genetic engineering of canola.

  14. The mental health care model in Brazil: analyses of the funding, governance processes, and mechanisms of assessment.

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    Trapé, Thiago Lavras; Campos, Rosana Onocko

    2017-03-23

    This study aims to analyze the current status of the mental health care model of the Brazilian Unified Health System, according to its funding, governance processes, and mechanisms of assessment. We have carried out a documentary analysis of the ordinances, technical reports, conference reports, normative resolutions, and decrees from 2009 to 2014. This is a time of consolidation of the psychosocial model, with expansion of the health care network and inversion of the funding for community services with a strong emphasis on the area of crack cocaine and other drugs. Mental health is an underfunded area within the chronically underfunded Brazilian Unified Health System. The governance model constrains the progress of essential services, which creates the need for the incorporation of a process of regionalization of the management. The mechanisms of assessment are not incorporated into the health policy in the bureaucratic field. There is a need to expand the global funding of the area of health, specifically mental health, which has been shown to be a successful policy. The current focus of the policy seems to be archaic in relation to the precepts of the psychosocial model. Mechanisms of assessment need to be expanded. Analisar o estágio atual do modelo de atenção à saúde mental do Sistema Único de Saúde, segundo seu financiamento, processos de governança e mecanismos de avaliação. Foi realizada uma análise documental de portarias, informes técnicos, relatórios de conferência, resoluções e decretos de 2009 a 2014. Trata-se de um momento de consolidação do modelo psicossocial, com ampliação da rede assistencial, inversão de financiamento para serviços comunitários com forte ênfase na área de crack e outras drogas. A saúde mental é uma área subfinanciada dentro do subfinanciamento crônico do Sistema Único de Saúde. O modelo de governança constrange o avanço de serviços essenciais, havendo a necessidade da incorporação de um

  15. Multi-tissue omics analyses reveal molecular regulatory networks for puberty in composite beef cattle.

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    Angela Cánovas

    Full Text Available Puberty is a complex physiological event by which animals mature into an adult capable of sexual reproduction. In order to enhance our understanding of the genes and regulatory pathways and networks involved in puberty, we characterized the transcriptome of five reproductive tissues (i.e. hypothalamus, pituitary gland, ovary, uterus, and endometrium as well as tissues known to be relevant to growth and metabolism needed to achieve puberty (i.e., longissimus dorsi muscle, adipose, and liver. These tissues were collected from pre- and post-pubertal Brangus heifers (3/8 Brahman; Bos indicus x 5/8 Angus; Bos taurus derived from a population of cattle used to identify quantitative trait loci associated with fertility traits (i.e., age of first observed corpus luteum (ACL, first service conception (FSC, and heifer pregnancy (HPG. In order to exploit the power of complementary omics analyses, pre- and post-puberty co-expression gene networks were constructed by combining the results from genome-wide association studies (GWAS, RNA-Seq, and bovine transcription factors. Eight tissues among pre-pubertal and post-pubertal Brangus heifers revealed 1,515 differentially expressed and 943 tissue-specific genes within the 17,832 genes confirmed by RNA-Seq analysis. The hypothalamus experienced the most notable up-regulation of genes via puberty (i.e., 204 out of 275 genes. Combining the results of GWAS and RNA-Seq, we identified 25 loci containing a single nucleotide polymorphism (SNP associated with ACL, FSC, and (or HPG. Seventeen of these SNP were within a gene and 13 of the genes were expressed in uterus or endometrium. Multi-tissue omics analyses revealed 2,450 co-expressed genes relative to puberty. The pre-pubertal network had 372,861 connections whereas the post-pubertal network had 328,357 connections. A sub-network from this process revealed key transcriptional regulators (i.e., PITX2, FOXA1, DACH2, PROP1, SIX6, etc.. Results from these multi

  16. Short-Term Electrical Peak Demand Forecasting in a Large Government Building Using Artificial Neural Networks

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    Jason Grant

    2014-03-01

    Full Text Available The power output capacity of a local electrical utility is dictated by its customers’ cumulative peak-demand electrical consumption. Most electrical utilities in the United States maintain peak-power generation capacity by charging for end-use peak electrical demand; thirty to seventy percent of an electric utility’s bill. To reduce peak demand, a real-time energy monitoring system was designed, developed, and implemented for a large government building. Data logging, combined with an application of artificial neural networks (ANNs, provides short-term electrical load forecasting data for controlled peak demand. The ANN model was tested against other forecasting methods including simple moving average (SMA, linear regression, and multivariate adaptive regression splines (MARSplines and was effective at forecasting peak building electrical demand in a large government building sixty minutes into the future. The ANN model presented here outperformed the other forecasting methods tested with a mean absolute percentage error (MAPE of 3.9% as compared to the SMA, linear regression, and MARSplines MAPEs of 7.7%, 17.3%, and 7.0% respectively. Additionally, the ANN model realized an absolute maximum error (AME of 8.2% as compared to the SMA, linear regression, and MARSplines AMEs of 26.2%, 45.1%, and 22.5% respectively.

  17. Predicting behavior change from persuasive messages using neural representational similarity and social network analyses.

    Science.gov (United States)

    Pegors, Teresa K; Tompson, Steven; O'Donnell, Matthew Brook; Falk, Emily B

    2017-08-15

    Neural activity in medial prefrontal cortex (MPFC), identified as engaging in self-related processing, predicts later health behavior change. However, it is unknown to what extent individual differences in neural representation of content and lived experience influence this brain-behavior relationship. We examined whether the strength of content-specific representations during persuasive messaging relates to later behavior change, and whether these relationships change as a function of individuals' social network composition. In our study, smokers viewed anti-smoking messages while undergoing fMRI and we measured changes in their smoking behavior one month later. Using representational similarity analyses, we found that the degree to which message content (i.e. health, social, or valence information) was represented in a self-related processing MPFC region was associated with later smoking behavior, with increased representations of negatively valenced (risk) information corresponding to greater message-consistent behavior change. Furthermore, the relationship between representations and behavior change depended on social network composition: smokers who had proportionally fewer smokers in their network showed increases in smoking behavior when social or health content was strongly represented in MPFC, whereas message-consistent behavior (i.e., less smoking) was more likely for those with proportionally more smokers in their social network who represented social or health consequences more strongly. These results highlight the dynamic relationship between representations in MPFC and key outcomes such as health behavior change; a complete understanding of the role of MPFC in motivation and action should take into account individual differences in neural representation of stimulus attributes and social context variables such as social network composition. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Modelling Inter-relationships among water, governance, human development variables in developing countries with Bayesian networks.

    Science.gov (United States)

    Dondeynaz, C.; Lopez-Puga, J.; Carmona-Moreno, C.

    2012-04-01

    Improving Water and Sanitation Services (WSS), being a complex and interdisciplinary issue, passes through collaboration and coordination of different sectors (environment, health, economic activities, governance, and international cooperation). This inter-dependency has been recognised with the adoption of the "Integrated Water Resources Management" principles that push for the integration of these various dimensions involved in WSS delivery to ensure an efficient and sustainable management. The understanding of these interrelations appears as crucial for decision makers in the water sector in particular in developing countries where WSS still represent an important leverage for livelihood improvement. In this framework, the Joint Research Centre of the European Commission has developed a coherent database (WatSan4Dev database) containing 29 indicators from environmental, socio-economic, governance and financial aid flows data focusing on developing countries (Celine et al, 2011 under publication). The aim of this work is to model the WatSan4Dev dataset using probabilistic models to identify the key variables influencing or being influenced by the water supply and sanitation access levels. Bayesian Network Models are suitable to map the conditional dependencies between variables and also allows ordering variables by level of influence on the dependent variable. Separated models have been built for water supply and for sanitation because of different behaviour. The models are validated if complying with statistical criteria but either with scientific knowledge and literature. A two steps approach has been adopted to build the structure of the model; Bayesian network is first built for each thematic cluster of variables (e.g governance, agricultural pressure, or human development) keeping a detailed level for interpretation later one. A global model is then built based on significant indicators of each cluster being previously modelled. The structure of the

  19. An Optimization Model for Expired Drug Recycling Logistics Networks and Government Subsidy Policy Design Based on Tri-level Programming.

    Science.gov (United States)

    Huang, Hui; Li, Yuyu; Huang, Bo; Pi, Xing

    2015-07-09

    In order to recycle and dispose of all people's expired drugs, the government should design a subsidy policy to stimulate users to return their expired drugs, and drug-stores should take the responsibility of recycling expired drugs, in other words, to be recycling stations. For this purpose it is necessary for the government to select the right recycling stations and treatment stations to optimize the expired drug recycling logistics network and minimize the total costs of recycling and disposal. This paper establishes a tri-level programming model to study how the government can optimize an expired drug recycling logistics network and the appropriate subsidy policies. Furthermore, a Hybrid Genetic Simulated Annealing Algorithm (HGSAA) is proposed to search for the optimal solution of the model. An experiment is discussed to illustrate the good quality of the recycling logistics network and government subsides obtained by the HGSAA. The HGSAA is proven to have the ability to converge on the global optimal solution, and to act as an effective algorithm for solving the optimization problem of expired drug recycling logistics network and government subsidies.

  20. An Optimization Model for Expired Drug Recycling Logistics Networks and Government Subsidy Policy Design Based on Tri-level Programming

    Directory of Open Access Journals (Sweden)

    Hui Huang

    2015-07-01

    Full Text Available In order to recycle and dispose of all people’s expired drugs, the government should design a subsidy policy to stimulate users to return their expired drugs, and drug-stores should take the responsibility of recycling expired drugs, in other words, to be recycling stations. For this purpose it is necessary for the government to select the right recycling stations and treatment stations to optimize the expired drug recycling logistics network and minimize the total costs of recycling and disposal. This paper establishes a tri-level programming model to study how the government can optimize an expired drug recycling logistics network and the appropriate subsidy policies. Furthermore, a Hybrid Genetic Simulated Annealing Algorithm (HGSAA is proposed to search for the optimal solution of the model. An experiment is discussed to illustrate the good quality of the recycling logistics network and government subsides obtained by the HGSAA. The HGSAA is proven to have the ability to converge on the global optimal solution, and to act as an effective algorithm for solving the optimization problem of expired drug recycling logistics network and government subsidies.

  1. Market analyses of livestock trade networks to inform the prevention of joint economic and epidemiological risks

    Science.gov (United States)

    Gilligan, Christopher A.; Belloc, Catherine; Filipe, João A. N.; Vergu, Elisabeta

    2016-01-01

    Conventional epidemiological studies of infections spreading through trade networks, e.g. via livestock movements, generally show that central large-size holdings (hubs) should be preferentially surveyed and controlled in order to reduce epidemic spread. However, epidemiological strategies alone may not be economically optimal when costs of control are factored in together with risks of market disruption from targeting core holdings in a supply chain. Using extensive data on animal movements in supply chains for cattle and swine in France, we introduce a method to identify effective strategies for preventing outbreaks with limited budgets while minimizing the risk of market disruptions. Our method involves the categorization of holdings based on position along the supply chain and degree of market share. Our analyses suggest that trade has a higher risk of propagating epidemics through cattle networks, which are dominated by exchanges involving wholesalers, than for swine. We assess the effectiveness of contrasting interventions from the perspectives of regulators and the market, using percolation analysis. We show that preferentially targeting minor, non-central agents can outperform targeting of hubs when the costs to stakeholders and the risks of market disturbance are considered. Our study highlights the importance of assessing joint economic–epidemiological risks in networks underlying pathogen propagation and trade. PMID:26984191

  2. Market analyses of livestock trade networks to inform the prevention of joint economic and epidemiological risks.

    Science.gov (United States)

    Moslonka-Lefebvre, Mathieu; Gilligan, Christopher A; Monod, Hervé; Belloc, Catherine; Ezanno, Pauline; Filipe, João A N; Vergu, Elisabeta

    2016-03-01

    Conventional epidemiological studies of infections spreading through trade networks, e.g., via livestock movements, generally show that central large-size holdings (hubs) should be preferentially surveyed and controlled in order to reduce epidemic spread. However, epidemiological strategies alone may not be economically optimal when costs of control are factored in together with risks of market disruption from targeting core holdings in a supply chain. Using extensive data on animal movements in supply chains for cattle and swine in France, we introduce a method to identify effective strategies for preventing outbreaks with limited budgets while minimizing the risk of market disruptions. Our method involves the categorization of holdings based on position along the supply chain and degree of market share. Our analyses suggest that trade has a higher risk of propagating epidemics through cattle networks, which are dominated by exchanges involving wholesalers, than for swine. We assess the effectiveness of contrasting interventions from the perspectives of regulators and the market, using percolation analysis. We show that preferentially targeting minor, non-central agents can outperform targeting of hubs when the costs to stakeholders and the risks of market disturbance are considered. Our study highlights the importance of assessing joint economic-epidemiological risks in networks underlying pathogen propagation and trade. © 2016 The Authors.

  3. Clinical research data warehouse governance for distributed research networks in the USA: a systematic review of the literature.

    Science.gov (United States)

    Holmes, John H; Elliott, Thomas E; Brown, Jeffrey S; Raebel, Marsha A; Davidson, Arthur; Nelson, Andrew F; Chung, Annie; La Chance, Pierre; Steiner, John F

    2014-01-01

    To review the published, peer-reviewed literature on clinical research data warehouse governance in distributed research networks (DRNs). Medline, PubMed, EMBASE, CINAHL, and INSPEC were searched for relevant documents published through July 31, 2013 using a systematic approach. Only documents relating to DRNs in the USA were included. Documents were analyzed using a classification framework consisting of 10 facets to identify themes. 6641 documents were retrieved. After screening for duplicates and relevance, 38 were included in the final review. A peer-reviewed literature on data warehouse governance is emerging, but is still sparse. Peer-reviewed publications on UK research network governance were more prevalent, although not reviewed for this analysis. All 10 classification facets were used, with some documents falling into two or more classifications. No document addressed costs associated with governance. Even though DRNs are emerging as vehicles for research and public health surveillance, understanding of DRN data governance policies and procedures is limited. This is expected to change as more DRN projects disseminate their governance approaches as publicly available toolkits and peer-reviewed publications. While peer-reviewed, US-based DRN data warehouse governance publications have increased, DRN developers and administrators are encouraged to publish information about these programs. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  4. Analysing collaboration among HIV agencies through combining network theory and relational coordination.

    Science.gov (United States)

    Khosla, Nidhi; Marsteller, Jill Ann; Hsu, Yea Jen; Elliott, David L

    2016-02-01

    Agencies with different foci (e.g. nutrition, social, medical, housing) serve people living with HIV (PLHIV). Serving needs of PLHIV comprehensively requires a high degree of coordination among agencies which often benefits from more frequent communication. We combined Social Network theory and Relational Coordination theory to study coordination among HIV agencies in Baltimore. Social Network theory implies that actors (e.g., HIV agencies) establish linkages amongst themselves in order to access resources (e.g., information). Relational Coordination theory suggests that high quality coordination among agencies or teams relies on the seven dimensions of frequency, timeliness and accuracy of communication, problem-solving communication, knowledge of agencies' work, mutual respect and shared goals. We collected data on frequency of contact from 57 agencies using a roster method. Response options were ordinal ranging from 'not at all' to 'daily'. We analyzed data using social network measures. Next, we selected agencies with which at least one-third of the sample reported monthly or more frequent interaction. This yielded 11 agencies whom we surveyed on seven relational coordination dimensions with questions scored on a Likert scale of 1-5. Network density, defined as the proportion of existing connections to all possible connections, was 20% when considering monthly or higher interaction. Relational coordination scores from individual agencies to others ranged between 1.17 and 5.00 (maximum possible score 5). The average scores for different dimensions across all agencies ranged between 3.30 and 4.00. Shared goals (4.00) and mutual respect (3.91) scores were highest, while scores such as knowledge of each other's work and problem-solving communication were relatively lower. Combining theoretically driven analyses in this manner offers an innovative way to provide a comprehensive picture of inter-agency coordination and the quality of exchange that underlies

  5. A mixed-methods approach for analysing social support and social anchorage of single mothers’ personal networks

    NARCIS (Netherlands)

    Lumino, Rosaria; Ragozini, Giancarlo; van Duijn, Marijtje; Vitale, Maria Prosperina

    2017-01-01

    The present paper analyses the relationship among social support and personal networks by focusing on social anchorage, which is a specific dimension of social support conveying to what extent people feel integrated into their personal networks. Specifying when, why, and how personal relationships

  6. Public Management and the Metagovernance of Hierarchies, Networks and Markets: The feasibility of designing and managing governance style combinations

    NARCIS (Netherlands)

    A.A.M. Meuleman (Louis)

    2008-01-01

    textabstractWhat is modern governance? Is it the battle against "oldfashioned" hierarchy, or is it the restoration of key hierarchical values? Is it optimizing network management, or maximizing the benefits of market thinking in the publicsector? This book argues that it is the combination of all

  7. A Measure of Systems Engineering Effectiveness in Government Acquisition of Complex Information Systems: A Bayesian Belief Network-Based Approach

    Science.gov (United States)

    Doskey, Steven Craig

    2014-01-01

    This research presents an innovative means of gauging Systems Engineering effectiveness through a Systems Engineering Relative Effectiveness Index (SE REI) model. The SE REI model uses a Bayesian Belief Network to map causal relationships in government acquisitions of Complex Information Systems (CIS), enabling practitioners to identify and…

  8. The Effects of Media and their Logic on Legitimacy Sources within Local Governance Networks: A Three-Case Comparative Study

    NARCIS (Netherlands)

    I.A. Korthagen (Iris); I.F. van Meerkerk (Ingmar)

    2014-01-01

    markdownabstract__Abstract__ Although theoretical and empirical work on the democratic legitimacy of governance networks is growing, little attention has been paid to the impact of mediatisation on democracies. Media have their own logic of news-making led by the media’s rules, aims,

  9. Using Ostrom’s DPs as Fuzzy Sets to Analyse How Water Policies Challenge Community-Based Water Governance in Colombia

    Directory of Open Access Journals (Sweden)

    María Mar Delgado-Serrano

    2017-07-01

    Full Text Available Ostrom’s design principles have been broadly used to analyse the governance of common pool resources. However, they are normally assessed as present or absent. We challenge this assumption by considering them as fuzzy sets where membership scores range from 0 to 1, because, in real situations, the design principles can be present at a certain level. We define categories to assess the level of membership and apply it to a single case study analysing how changes in water policy can affect the community-based management of the Water User Association of Mondomo (Colombia. In rural areas of Colombia, most water and sanitation services are provided by water user associations, wherein civil society has developed governance systems based on active citizen involvement and community-based management. Some of these associations have been operating for decades and are essential pillars of the local social fabric. However, recent changes in the country’s policy and legal framework threaten these long-lasting governance systems. The results show that most of the design principles would suffer important changes that undermine the governance system. Essential principles for sustainable community-based governance, such as the congruence of the rules with local conditions, the local monitoring and sanctioning capacities, the internal conflict-resolution mechanisms and the recognition of the rights to organize, are dramatically reduced after the policy implementation.

  10. Connecting Social Networks with Ecosystem Services for Watershed Governance: a Social-Ecological Network Perspective Highlights the Critical Role of Bridging Organizations

    Directory of Open Access Journals (Sweden)

    Kaitlyn J. Rathwell

    2012-06-01

    Full Text Available In many densely settled agricultural watersheds, water quality is a point of conflict between amenity and agricultural activities because of the varied demands and impacts on shared water resources. Successful governance of these watersheds requires coordination among different activities. Recent research has highlighted the role that social networks between management entities can play to facilitate cross-scale interaction in watershed governance. For example, bridging organizations can be positioned in social networks to bridge local initiatives done by single municipalities across whole watersheds. To better understand the role of social networks in social-ecological system dynamics, we combine a social network analysis of the water quality management networks held by local governments with a social-ecological analysis of variation in water management and ecosystem services across the Montérégie, an agricultural landscape near Montréal, Québec, Canada. We analyze municipal water management networks by using one-mode networks to represent direct collaboration between municipalities, and two-mode networks to capture how bridging organizations indirectly connect municipalities. We find that municipalities do not collaborate directly with one another but instead are connected via bridging organizations that span the water quality management network. We also discovered that more connected municipalities engaged in more water management activities. However, bridging organizations preferentially connected with municipalities that used more tourism related ecosystem services rather than those that used more agricultural ecosystem services. Many agricultural municipalities were relatively isolated, despite being the main producers of water quality problems. In combination, these findings suggest that further strengthening the water management network in the Montérégie will contribute to improving water quality in the region. However, such

  11. Networks and knowledge at the interface Governing the coast of East Kalimantan

    Directory of Open Access Journals (Sweden)

    Rini Kusumawati

    2016-05-01

    Full Text Available The thesis explores the actual processes of interaction between global and local actors regarding marine conservation and aquaculture development. The objective of the thesis is to analyse the collaboration, friction, and the cultural-historical, social, political, and economic contestations of the value and meaning of conservation from the perspectives of the district governmental agencies, the district head, local entrepreneurs and industry, and the international NGO. Concentrating on the dynamics of this global-local interface this thesis adds to existing literature because it helps us to understand why global environmental networks often face contention and even fail to be effective in their attempts to implement regulations or standards for a more sustainable production of coastal resources. The data were gathered during long-term anthropological fieldwork combining a political-ecology approach with environmental anthropology.

  12. A conceptual model for analysing informal learning in online social networks for health professionals.

    Science.gov (United States)

    Li, Xin; Gray, Kathleen; Chang, Shanton; Elliott, Kristine; Barnett, Stephen

    2014-01-01

    Online social networking (OSN) provides a new way for health professionals to communicate, collaborate and share ideas with each other for informal learning on a massive scale. It has important implications for ongoing efforts to support Continuing Professional Development (CPD) in the health professions. However, the challenge of analysing the data generated in OSNs makes it difficult to understand whether and how they are useful for CPD. This paper presents a conceptual model for using mixed methods to study data from OSNs to examine the efficacy of OSN in supporting informal learning of health professionals. It is expected that using this model with the dataset generated in OSNs for informal learning will produce new and important insights into how well this innovation in CPD is serving professionals and the healthcare system.

  13. Analyses of integrated aircraft cabin contaminant monitoring network based on Kalman consensus filter.

    Science.gov (United States)

    Wang, Rui; Li, Yanxiao; Sun, Hui; Chen, Zengqiang

    2017-11-01

    The modern civil aircrafts use air ventilation pressurized cabins subject to the limited space. In order to monitor multiple contaminants and overcome the hypersensitivity of the single sensor, the paper constructs an output correction integrated sensor configuration using sensors with different measurement theories after comparing to other two different configurations. This proposed configuration works as a node in the contaminant distributed wireless sensor monitoring network. The corresponding measurement error models of integrated sensors are also proposed by using the Kalman consensus filter to estimate states and conduct data fusion in order to regulate the single sensor measurement results. The paper develops the sufficient proof of the Kalman consensus filter stability when considering the system and the observation noises and compares the mean estimation and the mean consensus errors between Kalman consensus filter and local Kalman filter. The numerical example analyses show the effectiveness of the algorithm. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  14. Using System Dynamic Model and Neural Network Model to Analyse Water Scarcity in Sudan

    Science.gov (United States)

    Li, Y.; Tang, C.; Xu, L.; Ye, S.

    2017-07-01

    Many parts of the world are facing the problem of Water Scarcity. Analysing Water Scarcity quantitatively is an important step to solve the problem. Water scarcity in a region is gauged by WSI (water scarcity index), which incorporate water supply and water demand. To get the WSI, Neural Network Model and SDM (System Dynamic Model) that depict how environmental and social factors affect water supply and demand are developed to depict how environmental and social factors affect water supply and demand. The uneven distribution of water resource and water demand across a region leads to an uneven distribution of WSI within this region. To predict WSI for the future, logistic model, Grey Prediction, and statistics are applied in predicting variables. Sudan suffers from severe water scarcity problem with WSI of 1 in 2014, water resource unevenly distributed. According to the result of modified model, after the intervention, Sudan’s water situation will become better.

  15. Robust artificial neural network for reliability and sensitivity analyses of complex non-linear systems.

    Science.gov (United States)

    Oparaji, Uchenna; Sheu, Rong-Jiun; Bankhead, Mark; Austin, Jonathan; Patelli, Edoardo

    2017-12-01

    Artificial Neural Networks (ANNs) are commonly used in place of expensive models to reduce the computational burden required for uncertainty quantification, reliability and sensitivity analyses. ANN with selected architecture is trained with the back-propagation algorithm from few data representatives of the input/output relationship of the underlying model of interest. However, different performing ANNs might be obtained with the same training data as a result of the random initialization of the weight parameters in each of the network, leading to an uncertainty in selecting the best performing ANN. On the other hand, using cross-validation to select the best performing ANN based on the ANN with the highest R 2 value can lead to biassing in the prediction. This is as a result of the fact that the use of R 2 cannot determine if the prediction made by ANN is biased. Additionally, R 2 does not indicate if a model is adequate, as it is possible to have a low R 2 for a good model and a high R 2 for a bad model. Hence, in this paper, we propose an approach to improve the robustness of a prediction made by ANN. The approach is based on a systematic combination of identical trained ANNs, by coupling the Bayesian framework and model averaging. Additionally, the uncertainties of the robust prediction derived from the approach are quantified in terms of confidence intervals. To demonstrate the applicability of the proposed approach, two synthetic numerical examples are presented. Finally, the proposed approach is used to perform a reliability and sensitivity analyses on a process simulation model of a UK nuclear effluent treatment plant developed by National Nuclear Laboratory (NNL) and treated in this study as a black-box employing a set of training data as a test case. This model has been extensively validated against plant and experimental data and used to support the UK effluent discharge strategy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Coauthorship and institutional collaborations on cost-effectiveness analyses: a systematic network analysis.

    Directory of Open Access Journals (Sweden)

    Ferrán Catalá-López

    Full Text Available BACKGROUND: Cost-Effectiveness Analysis (CEA has been promoted as an important research methodology for determining the efficiency of healthcare technology and guiding medical decision-making. Our aim was to characterize the collaborative patterns of CEA conducted over the past two decades in Spain. METHODS AND FINDINGS: A systematic analysis was carried out with the information obtained through an updated comprehensive literature review and from reports of health technology assessment agencies. We identified CEAs with outcomes expressed as a time-based summary measure of population health (e.g. quality-adjusted life-years or disability-adjusted life-years, conducted in Spain and published between 1989 and 2011. Networks of coauthorship and institutional collaboration were produced using PAJEK software. One-hundred and thirty-one papers were analyzed, in which 526 authors and 230 institutions participated. The overall signatures per paper index was 5.4. Six major groups (one with 14 members, three with 7 members and two with 6 members were identified. The most prolific authors were generally affiliated with the private-for-profit sector (e.g. consulting firms and the pharmaceutical industry. The private-for-profit sector maintains profuse collaborative networks including public hospitals and academia. Collaboration within the public sector (e.g. healthcare administration and primary care was weak and fragmented. CONCLUSIONS: This empirical analysis reflects critical practices among collaborative networks that contributed substantially to the production of CEA, raises challenges for redesigning future policies and provides a framework for similar analyses in other regions.

  17. Modeling ecological drivers in marine viral communities using comparative metagenomics and network analyses.

    Science.gov (United States)

    Hurwitz, Bonnie L; Westveld, Anton H; Brum, Jennifer R; Sullivan, Matthew B

    2014-07-22

    Long-standing questions in marine viral ecology are centered on understanding how viral assemblages change along gradients in space and time. However, investigating these fundamental ecological questions has been challenging due to incomplete representation of naturally occurring viral diversity in single gene- or morphology-based studies and an inability to identify up to 90% of reads in viral metagenomes (viromes). Although protein clustering techniques provide a significant advance by helping organize this unknown metagenomic sequence space, they typically use only ∼75% of the data and rely on assembly methods not yet tuned for naturally occurring sequence variation. Here, we introduce an annotation- and assembly-free strategy for comparative metagenomics that combines shared k-mer and social network analyses (regression modeling). This robust statistical framework enables visualization of complex sample networks and determination of ecological factors driving community structure. Application to 32 viromes from the Pacific Ocean Virome dataset identified clusters of samples broadly delineated by photic zone and revealed that geographic region, depth, and proximity to shore were significant predictors of community structure. Within subsets of this dataset, depth, season, and oxygen concentration were significant drivers of viral community structure at a single open ocean station, whereas variability along onshore-offshore transects was driven by oxygen concentration in an area with an oxygen minimum zone and not depth or proximity to shore, as might be expected. Together these results demonstrate that this highly scalable approach using complete metagenomic network-based comparisons can both test and generate hypotheses for ecological investigation of viral and microbial communities in nature.

  18. Network Analyses in Systems Biology: New Strategies for Dealing with Biological Complexity

    DEFF Research Database (Denmark)

    Green, Sara; Serban, Maria; Scholl, Raphael

    2018-01-01

    The increasing application of network models to interpret biological systems raises a number of important methodological and epistemological questions. What novel insights can network analysis provide in biology? Are network approaches an extension of or in conflict with mechanistic research...

  19. What's So Special About Policy Networks? An Exploration of the Concept and Its Usefulness in Studying European Governance

    Directory of Open Access Journals (Sweden)

    Tanja A. Börzel

    1997-08-01

    Full Text Available A 'Babylonian' variety of policy network concepts and applications can be found in the literature. Neither is there a common understanding of what a policy networks actually is, nor has it been agreed upon whether policy networks constitute a mere metaphor, a method, an analytical tool or a proper theory. The aim of this paper is to review the state of the art in the field of policy networks and to explore their usefulness in studying European policy-making and European governance. It is argued that policy networks are more than an analytical tool box for studying these phenomena. What is so special then about policy networks? They constitute arenas for non-strategic, communicative action providing solutions for collective action problems and accounting for more efficient and legitimate policy-making. Yet, a theoretically ambitious policy network approach has to, first, show that policy networks do not only exist but are relevant for policy process and policy outcome, and second, tackle the problem of the ambiguity of policy networks, which can do both enhance and reduce the efficiency and legitimacy of policy-making.

  20. What's So Special About Policy Networks? – An Exploration of the Concept and Its Usefulness in Studying European Governance

    Directory of Open Access Journals (Sweden)

    Tanja A. Börzel

    1997-08-01

    Full Text Available A 'Babylonian' variety of policy network concepts and applications can be found in the literature. Neither is there a common understanding of what a policy networks actually is, nor has it been agreed upon whether policy networks constitute a mere metaphor, a method, an analytical tool or a proper theory. The aim of this paper is to review the state of the art in the field of policy networks and to explore their usefulness in studying European policy-making and European governance. It is argued that policy networks are more than an analytical tool box for studying these phenomena. What is so special then about policy networks? They constitute arenas for non-strategic, communicative action providing solutions for collective action problems and accounting for more efficient and legitimate policy-making. Yet, a theoretically ambitious policy network approach has to, first, show that policy networks do not only exist but are relevant for policy process and policy outcome, and second, tackle the problem of the ambiguity of policy networks, which can do both enhance and reduce the efficiency and legitimacy of policy-making.

  1. Theorizing benefits and constraints in collaborative environmental governance: a transdisciplinary social-ecological network approach for empirical investigations

    Directory of Open Access Journals (Sweden)

    Örjan Bodin

    2016-03-01

    Full Text Available When environmental processes cut across socioeconomic boundaries, traditional top-down government approaches struggle to effectively manage and conserve ecosystems. In such cases, governance arrangements that foster multiactor collaboration are needed. The effectiveness of such arrangements, however, depends on how well any ecological interdependencies across governed ecosystems are aligned with patterns of collaboration. This inherent interdisciplinary and complex problem has impeded progress in developing a better understanding of how to govern ecosystems for conservation in an increasingly interconnected world. We argue for the development of empirically informed theories, which are not only able to transcend disciplinary boundaries, but are also explicit in taking these complex social-ecological interdependences into account. We show how this emerging research frontier can be significantly improved by incorporating recent advances in stochastic modeling of multilevel social networks. An empirical case study from an agricultural landscape in Madagascar is reanalyzed to demonstrate these improvements.

  2. Analysing the Correlation between Social Network Analysis Measures and Performance of Students in Social Network-Based Engineering Education

    Science.gov (United States)

    Putnik, Goran; Costa, Eric; Alves, Cátia; Castro, Hélio; Varela, Leonilde; Shah, Vaibhav

    2016-01-01

    Social network-based engineering education (SNEE) is designed and implemented as a model of Education 3.0 paradigm. SNEE represents a new learning methodology, which is based on the concept of social networks and represents an extended model of project-led education. The concept of social networks was applied in the real-life experiment,…

  3. Diffusion of innovation: a social network and organizational learning approach to governance of a districtwide leadership team

    Directory of Open Access Journals (Sweden)

    Yi-Hwa Liou

    2016-04-01

    Full Text Available District and school leaders play particularly important roles in leading districtwide improvement, as they are increasingly held accountable for bringing about change and improvement for educational innovation and excellence.  While conventional districtwide governance places much of its focus on technical and administrative matters such as policy development, supervision, and monitoring progress. This technical focus often overlooks the fundamental aspect that drives the progress of improvement—the social infrastructure shaped by interpersonal relationship. Responding to recent scholarships that calls for a networked approach to governance, this study examined the change effort of a districtwide leadership team over three points in time drawing on social network theory and analysis focused on district governance.  Specifically, we focused on the type of interpersonal relationship in which leaders engaged with each other in sharing and exchanging innovative ideas as these efforts may support better governance. Additionally, we explored organizational learning as a way to examine climate in support of districtwide innovative efforts during change process. Our findings from leaders indicated increased innovative behaviors and perceived climate on organizational learning over time. The findings suggested that leaders increased connections around risk taking, regardless of their work level over time. This increased connectedness around innovation was coupled with an increase in leaders’ perception of the district’s learning climate, suggesting a cohesive approach to governance and improvement.

  4. Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015.

    Science.gov (United States)

    Petropoulou, Maria; Nikolakopoulou, Adriani; Veroniki, Areti-Angeliki; Rios, Patricia; Vafaei, Afshin; Zarin, Wasifa; Giannatsi, Myrsini; Sullivan, Shannon; Tricco, Andrea C; Chaimani, Anna; Egger, Matthias; Salanti, Georgia

    2017-02-01

    To assess the characteristics and core statistical methodology specific to network meta-analyses (NMAs) in clinical research articles. We searched MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from inception until April 14, 2015, for NMAs of randomized controlled trials including at least four different interventions. Two reviewers independently screened potential studies, whereas data abstraction was performed by a single reviewer and verified by a second. A total of 456 NMAs, which included a median (interquartile range) of 21 (13-40) studies and 7 (5-9) treatment nodes, were assessed. A total of 125 NMAs (27%) were star networks; this proportion declined from 100% in 2005 to 19% in 2015 (P = 0.01 by test of trend). An increasing number of NMAs discussed transitivity or inconsistency (0% in 2005, 86% in 2015, P < 0.01) and 150 (45%) used appropriate methods to test for inconsistency (14% in 2006, 74% in 2015, P < 0.01). Heterogeneity was explored in 256 NMAs (56%), with no change over time (P = 0.10). All pairwise effects were reported in 234 NMAs (51%), with some increase over time (P = 0.02). The hierarchy of treatments was presented in 195 NMAs (43%), the probability of being best was most commonly reported (137 NMAs, 70%), but use of surface under the cumulative ranking curves increased steeply (0% in 2005, 33% in 2015, P < 0.01). Many NMAs published in the medical literature have significant limitations in both the conduct and reporting of the statistical analysis and numerical results. The situation has, however, improved in recent years, in particular with respect to the evaluation of the underlying assumptions, but considerable room for further improvements remains. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Network meta-analyses could be improved by searching more sources and by involving a librarian.

    Science.gov (United States)

    Li, Lun; Tian, Jinhui; Tian, Hongliang; Moher, David; Liang, Fuxiang; Jiang, Tongxiao; Yao, Liang; Yang, Kehu

    2014-09-01

    Network meta-analyses (NMAs) aim to rank the benefits (or harms) of interventions, based on all available randomized controlled trials. Thus, the identification of relevant data is critical. We assessed the conduct of the literature searches in NMAs. Published NMAs were retrieved by searching electronic bibliographic databases and other sources. Two independent reviewers selected studies and five trained reviewers abstracted data regarding literature searches, in duplicate. Search method details were examined using descriptive statistics. Two hundred forty-nine NMAs were included. Eight used previous systematic reviews to identify primary studies without further searching, and five did not report any literature searches. In the 236 studies that used electronic databases to identify primary studies, the median number of databases was 3 (interquartile range: 3-5). MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were the most commonly used databases. The most common supplemental search methods included reference lists of included studies (48%), reference lists of previous systematic reviews (40%), and clinical trial registries (32%). None of these supplemental methods was conducted in more than 50% of the NMAs. Literature searches in NMAs could be improved by searching more sources, and by involving a librarian or information specialist. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Two novel antimicrobial defensins from rice identified by gene coexpression network analyses.

    Science.gov (United States)

    Tantong, Supaluk; Pringsulaka, Onanong; Weerawanich, Kamonwan; Meeprasert, Arthitaya; Rungrotmongkol, Thanyada; Sarnthima, Rakrudee; Roytrakul, Sittiruk; Sirikantaramas, Supaart

    2016-10-01

    Defensins form an antimicrobial peptides (AMP) family, and have been widely studied in various plants because of their considerable inhibitory functions. However, their roles in rice (Oryza sativa L.) have not been characterized, even though rice is one of the most important staple crops that is susceptible to damaging infections. Additionally, a previous study identified 598 rice genes encoding cysteine-rich peptides, suggesting there are several uncharacterized AMPs in rice. We performed in silico gene expression and coexpression network analyses of all genes encoding defensin and defensin-like peptides, and determined that OsDEF7 and OsDEF8 are coexpressed with pathogen-responsive genes. Recombinant OsDEF7 and OsDEF8 could form homodimers. They inhibited the growth of the bacteria Xanthomonas oryzae pv. oryzae, X. oryzae pv. oryzicola, and Erwinia carotovora subsp. atroseptica with minimum inhibitory concentration (MIC) ranging from 0.6 to 63μg/mL. However, these OsDEFs are weakly active against the phytopathogenic fungi Helminthosporium oryzae and Fusarium oxysporum f.sp. cubense. This study describes a useful method for identifying potential plant AMPs with biological activities. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Assessment of abnormal brain structures and networks in major depressive disorder using morphometric and connectome analyses.

    Science.gov (United States)

    Chen, Vincent Chin-Hung; Shen, Chao-Yu; Liang, Sophie Hsin-Yi; Li, Zhen-Hui; Tyan, Yeu-Sheng; Liao, Yin-To; Huang, Yin-Chen; Lee, Yena; McIntyre, Roger S; Weng, Jun-Cheng

    2016-11-15

    It is hypothesized that the phenomenology of major depressive disorder (MDD) is subserved by disturbances in the structure and function of brain circuits; however, findings of structural abnormalities using MRI have been inconsistent. Generalized q-sampling imaging (GQI) methodology provides an opportunity to assess the functional integrity of white matter tracts in implicated circuits. The study population was comprised of 16 outpatients with MDD (mean age 44.81±2.2 years) and 30 age- and gender-matched healthy controls (mean age 45.03±1.88 years). We excluded participants with any other primary mental disorder, substance use disorder, or any neurological illnesses. We used T1-weighted 3D MRI with voxel-based morphometry (VBM) and vertex-wise shape analysis, and GQI with voxel-based statistical analysis (VBA), graph theoretical analysis (GTA) and network-based statistical (NBS) analysis to evaluate brain structure and connectivity abnormalities in MDD compared to healthy controls correlates with clinical measures of depressive symptom severity, Hamilton Depression Rating Scale 17-item (HAMD) and Hospital Anxiety and Depression Scale (HADS). Using VBM and vertex-wise shape analyses, we found significant volumetric decreases in the hippocampus and amygdala among subjects with MDD (pbrain disorder with abnormal circuit structure and connectivity. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Analysing Health Professionals' Learning Interactions in an Online Social Network: A Longitudinal Study.

    Science.gov (United States)

    Li, Xin; Verspoor, Karin; Gray, Kathleen; Barnett, Stephen

    2016-01-01

    This paper summarises a longitudinal analysis of learning interactions occurring over three years among health professionals in an online social network. The study employs the techniques of Social Network Analysis (SNA) and statistical modeling to identify the changes in patterns of interaction over time and test associated structural network effects. SNA results indicate overall low participation in the network, although some participants became active over time and even led discussions. In particular, the analysis has shown that a change of lead contributor results in a change in learning interaction and network structure. The analysis of structural network effects demonstrates that the interaction dynamics slow down over time, indicating that interactions in the network are more stable. The health professionals may be reluctant to share knowledge and collaborate in groups but were interested in building personal learning networks or simply seeking information.

  9. SINISTER CONNECTIONS: HOW TO ANALYSE ORGANISED CRIME WITH SOCIAL NETWORK ANALYSIS?

    NARCIS (Netherlands)

    Diviak, Tomas

    2018-01-01

    Networks have recently become ubiquitous in many scientific fields. In criminology, social network analysis (SNA) provides a potent tool for analysis of organized crime. This paper introduces basic network terms and measures as well as advanced models and reviews their application in criminological

  10. Sinister connections : how to analyse organised crime with social network analysis?

    NARCIS (Netherlands)

    Diviak, Tomas

    2018-01-01

    Networks have recently become ubiquitous in many scientific fields. In criminology, social network analysis (SNA) provides a potent tool for analysis of organized crime. This paper introduces basic network terms and measures as well as advanced models and reviews their application in criminological

  11. Transcriptional and epigenetic analyses of the DMD locus reveal novel cis‑acting DNA elements that govern muscle dystrophin expression.

    Science.gov (United States)

    Gherardi, Samuele; Bovolenta, Matteo; Passarelli, Chiara; Falzarano, Maria Sofia; Pigini, Paolo; Scotton, Chiara; Neri, Marcella; Armaroli, Annarita; Osman, Hana; Selvatici, Rita; Gualandi, Francesca; Recchia, Alessandra; Mora, Marina; Bernasconi, Pia; Maggi, Lorenzo; Morandi, Lucia; Ferlini, Alessandra; Perini, Giovanni

    2017-11-01

    The dystrophin gene (DMD) is the largest gene in the human genome, mapping on the Xp21 chromosome locus. It spans 2.2Mb and accounts for approximately 0,1% of the entire human genome. Mutations in this gene cause Duchenne and Becker Muscular Dystrophy, X-linked Dilated Cardiomyopathy, and other milder muscle phenotypes. Beside the remarkable number of reports describing dystrophin gene expression and the pathogenic consequences of the gene mutations in dystrophinopathies, the full scenario of the DMD transcription dynamics remains however, poorly understood. Considering that the full transcription of the DMD gene requires about 16h, we have investigated the activity of RNA Polymerase II along the entire DMD locus within the context of specific chromatin modifications using a variety of chromatin-based techniques. Our results unveil a surprisingly powerful processivity of the RNA polymerase II along the entire 2.2Mb of the DMD locus with just one site of pausing around intron 52. We also discovered epigenetic marks highlighting the existence of four novel cis‑DNA elements, two of which, located within intron 34 and exon 45, appear to govern the architecture of the DMD chromatin with implications on the expression levels of the muscle dystrophin mRNA. Overall, our findings provide a global view on how the entire DMD locus is dynamically transcribed by the RNA pol II and shed light on the mechanisms involved in dystrophin gene expression control, which can positively impact on the optimization of the novel ongoing therapeutic strategies for dystrophinopathies. Copyright © 2017. Published by Elsevier B.V.

  12. Value and usability of unpublished data sources for systematic reviews and network meta-analyses.

    Science.gov (United States)

    Halfpenny, Nicholas James Anthony; Quigley, Joan Mary; Thompson, Juliette Catherine; Scott, David Alexander

    2016-12-01

    Peer-reviewed publications and conference proceedings are the mainstay of data sources for systematic reviews and network meta-analyses (NMA), but access to informative unpublished data is now becoming commonplace. To explore the usefulness of three types of 'grey' literature-clinical trials registries, clinical study reports and data from regulatory authorities-we conducted four case studies. The reporting of outcome data in peer-reviewed publications, the clinical trials registries and the clinical study reports for two clinical trials-one in melanoma, one in juvenile idiopathic arthritis (JIA)-was examined. In addition, we assessed the value of including unpublished data from the European Medicines Agency (EMA) and US Food and Drug Administration (FDA) in evidence syntheses of hepatitis C virus (HCV) and chronic obstructive pulmonary disease (COPD), respectively. For the clinical trials in melanoma and JIA, we identified outcome parameters on ClinicalTrials.gov additional to those reported in the peer-reviewed publications: subgroup data and additional efficacy end points/extended follow-up, respectively. The clinical study report also provided results for several subgroups unavailable elsewhere. For HCV and COPD, additional outcome data were obtained from the EMA European Public Assessment Report (EPAR) and the FDA, respectively, including data on subgroups and mortality. We conclude that data from these grey literature sources have the potential to influence results of systematic reviews and NMAs, and may thus have implications for healthcare decisions. However, it is important to consider carefully the availability, reliability and consequent usability of these data sources in systematic reviews and NMAs. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  13. Two-terminal reliability analyses for a mobile ad hoc wireless network

    International Nuclear Information System (INIS)

    Cook, Jason L.; Ramirez-Marquez, Jose Emmanuel

    2007-01-01

    Reliability is one of the most important performance measures for emerging technologies. For these systems, shortcomings are often overlooked in early releases as the cutting edge technology overshadows a fragile design. Currently, the proliferation of the mobile ad hoc wireless networks (MAWN) is moving from cutting edge to commodity and thus, reliable performance will be expected. Generally, ad hoc networking is applied for the flexibility and mobility it provides. As a result, military and first responders employ this network scheme and the reliability of the network becomes paramount. To ensure reliability is achieved, one must first be able to analyze and calculate the reliability of the MAWN. This work describes the unique attributes of the MAWN and how the classical analysis of network reliability, where the network configuration is known a priori, can be adjusted to model and analyze this type of network. The methods developed acknowledge the dynamic and scalable nature of the MAWN along with its absence of infrastructure. Thus, the methods rely on a modeling approach that considers the probabilistic formation of different network configurations in a MAWN. Hence, this paper proposes reliability analysis methods that consider the effect of node mobility and the continuous changes in the network's connectivity

  14. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study

    NARCIS (Netherlands)

    Luca, G. De; Haba-Rubio, J.; Dauvilliers, Y.; Lammers, G.J.; Overeem, S.; Donjacour, C.E.; Mayer, G.; Javidi, S.; Iranzo, A.; Santamaria, J.; Peraita-Adrados, R.; Hor, H.; Kutalik, Z.; Plazzi, G.; Poli, F.; Pizza, F.; Arnulf, I.; Lecendreux, M.; Bassetti, C.; Mathis, J.; Heinzer, R.; Jennum, P.; Knudsen, S.; Geisler, P.; Wierzbicka, A.; Feketeova, E.; Pfister, C.; Khatami, R.; Baumann, C.; Tafti, M.; et al.,

    2013-01-01

    The aim of this study was to describe the clinical and PSG characteristics of narcolepsy with cataplexy and their genetic predisposition by using the retrospective patient database of the European Narcolepsy Network (EU-NN). We have analysed retrospective data of 1099 patients with narcolepsy

  15. The Use Of Information And Communication Technology And Social Networking Sites In Political Governance Of East African Legislative Assembly Parliament

    Directory of Open Access Journals (Sweden)

    Ainebyona Robert

    2015-06-01

    Full Text Available Abstract This research project was carried out to ascertain the use of Information and Communication Technologies and Social Networking Sites in political governance of East African Legislative Assembly Parliament. The research project was based on the conviction that in this era of globalization use of ICTs and SNSs are fundamentally important and will have tremendous impact on governance leadership and legislation now and in the near future. The specific objective of this study was intended a To evaluate the use of Social Networking Sites in enhancing the political governance of East African Legislative assembly Parliament. The findings from the research showed that that all the respondents 100 were subscribed to social networking sites and used them from time to time. Additionally the EALA parliamentarians had a disparity when it came to use of SNSs to interact with constituents 73.3 of the respondents indicated that they have used SNSs to interact with constituents on matters affecting the community from time to time however 26.7 showed that they did not use Social Networking sites to interact with constituents. Lastly the use of ICTs and SNSs by EALA has also made it possible for citizens to view Assembly proceedings in real time and hence where able to view their representatives in the course of carrying out their duties in the political arena.Lastly the world is changing in a dynamic fashion SNSs are among the tools leading the transformation and it is about time Parliamentarians in Africa embrace SNSs as major tools in changing how leaders interact and remain accountable to their constituents a practice thats been a myth in Africa.

  16. Application of the Strategic Alignment Model and Information Technology Governance Concepts to Support Network Centric Warfare

    National Research Council Canada - National Science Library

    Valentine, Jennifer R

    2006-01-01

    .... This thesis proposes that while the two areas? success fundamentally resides in the implementation and exploitation of technology, it is only through sound IT Governance policies and strategic alignment practices that success can be measured...

  17. Building a Foundation for Knowledge Co-Creation in Collaborative Water Governance: Dimensions of Stakeholder Networks Facilitated through Bridging Organizations

    Directory of Open Access Journals (Sweden)

    Wietske Medema

    2017-01-01

    Full Text Available The sustainable governance of water resources relies on processes of multi-stakeholder collaborations and interactions that facilitate the sharing and integration of diverse sources and types of knowledge. In this context, it is essential to fully recognize the importance of fostering and enhancing critical connections within and between networks of relationships between different government and non-government agencies, as well as the dynamics that are in support of the development of new knowledge and practices. In Quebec, a network of watershed organizations (WOs has been put in place to serve as bridging organizations (BOs for stakeholder groups in their watershed territories. Using the WOs as a case study, this research aims to contribute to a greater understanding of how stakeholder groups can be effectively connected to support knowledge co-creation through networked relationships facilitated by BOs. In line with this overall research aim, the following research objectives are proposed: (1 to assess the quality of the knowledge that is developed and shared through the WOs and their stakeholder networks; (2 to determine the characteristics of stakeholders participating in the WOs’ networks that either hinder or support collaborations and knowledge co-creation; (3 to describe the collaborative processes and mechanisms through which the WOs facilitate stakeholder interactions and knowledge co-creation; and (4 to assess the quality of the relationships and interactions between stakeholders participating in the WOs’ collaborative networks. A comprehensive literature review is provided of collaborative network dimensions that are in support of knowledge co-creation that forms the foundation of a research framework to assess knowledge co-creation processes that are facilitated through BOs and their collaborative networks. Documented experiences have been gathered through face-to-face semi-structured interviews, as well as a Quebec-wide survey

  18. Sinister connections: How to analyse organised crime with social network analysis?

    Directory of Open Access Journals (Sweden)

    Tomáš Diviák

    2018-04-01

    Full Text Available Networks have recently become ubiquitous in many scientific fields. In criminology, social network analysis (SNA provides a potent tool for analysis of organized crime. This paper introduces basic network terms and measures as well as advanced models and reviews their application in criminological research. The centrality measures – degree and betweenness – are introduced as means to describe relative importance of actors in the network. The centrality measures are useful also in determining strategically positioned actors within the network or providing efficient targets for disruption of criminal networks. The cohesion measures, namely density, centralization, and average geodesic distance are described and their relevance is related to the idea of efficiency-security trade-off. As the last of the basic measures, the attention is paid to subgroup identification algorithms such as cliques, k-plexes, and factions. Subgroups are essential in the discussion on the cell-structure in criminal networks. The following part of the paper is a brief overview of more sophisticated network models. Models allow for theory testing, distinguishing systematic processes from randomness, and simplification of complex network structures. Quadratic assignment procedure, blockmodels, exponential random graph models, and stochastic actor-oriented models are covered. Some important research examples include similarities in co-offending, core-periphery structures, closure and brokerage, and network evolution. Subsequently, the paper reflects the three biggest challenges for application of SNA to criminal settings – data availability, proper formulation of theories and adequate methods application. In conclusion, readers are referred to books and journals combining SNA and criminology as well as to software suitable to carry out SNA.

  19. Complexity in the governance of tourism networks : Balancing between external pressure and internal expectations

    NARCIS (Netherlands)

    van der Zee, Egbert|info:eu-repo/dai/nl/413578291; Gerrets, Anne-Mara; Vanneste, Dominique

    2017-01-01

    Tourism destinations are complex systems of interrelated entities without a hierarchical chain of command. In order to enhance the ability of destinations to create a high quality, authentic tourism experience, a management perspective based on networks, personal relationships, trust, and

  20. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells

    DEFF Research Database (Denmark)

    Shih, Hung Ping; Seymour, Philip A; Patel, Nisha A

    2015-01-01

    9 as cooperative inducers of a gene regulatory network that distinguishes the pancreatic from the intestinal lineage. Genetic studies demonstrate dual and cooperative functions for Pdx1 and Sox9 in pancreatic lineage induction and repression of the intestinal lineage choice. Pdx1 and Sox9 bind...... to regulatory sequences near pancreatic and intestinal differentiation genes and jointly regulate their expression, revealing direct cooperative roles for Pdx1 and Sox9 in gene activation and repression. Our study identifies Pdx1 and Sox9 as important regulators of a transcription factor network that initiates...... pancreatic fate and sheds light on the gene regulatory circuitry that governs the development of distinct organs from multi-lineage-competent foregut progenitors....

  1. Government Agency and Trust in the Formation and Transformation of Interorganizational Entrepreneurial Networks

    DEFF Research Database (Denmark)

    Neergaard, Helle; Ulhøi, John Parm

    2006-01-01

    This article examines the role of trust and government agency in the creation and evolution of interoganizational cooperation among entrepreneurial ventures in general and the influence of trust on development trajectories in particular. The multiple-case approach used draws on five in-depth case...

  2. Cities, Networks, and Global Environmental Governance - Spaces of Innovation, Places of Leadership

    NARCIS (Netherlands)

    Bouteligier, S.

    2012-01-01

    As a result of global dynamics—the increasing interconnection of people and places—innovations in global environmental governance haved altered the role of cities in shaping the future of the planet. This book is a timely study of the importance of these social transformations in our increasingly

  3. Qualitative and Quantitative Security Analyses for ZigBee Wireless Sensor Networks

    DEFF Research Database (Denmark)

    Yuksel, Ender

    applications, home automation, and traffic control. The challenges for research in this area are due to the unique features of wireless sensor devices such as low processing power and associated low energy. On top of this, wireless sensor networks need secure communication as they operate in open fields...... of the main challenges arise in dealing with the security needs of such systems where it is less likely that absolute security guarantees can be sustained - because of the need to balance security against energy consumption in wireless sensor network standards like ZigBee. This dissertation builds on existing...... low level security protocol s in a qualitative manner and guarantees absolute security, and then takes these verified protocols as actions of scenarios to be verified in a quantitative manner. Working on the emerging ZigBee wireless sensor networks, we used probabilistic verification that can return...

  4. Changes in a hydrographic network of the Słowiński National Park in terms of photogrammetric analyses

    Directory of Open Access Journals (Sweden)

    Góraj Maciej

    2017-12-01

    Full Text Available The main objective of this study is to evaluate the changes in the hydrographic network of Słowiński National Park. The authors analysed the changes occurring in the drainage network due to limited maintenance in this legally protected natural area. To accomplish this task, elaborations prepared on the basis of aerial photographs were used: an orthophoto map from 1996, hyperspectral imaging from June 2015, and a digital terrain model based on airborne laser scanning (ALS from June 2015. These spatial data resources enabled the digitisation of the water courses for which selected hydro-morphological features had been defined. As a result of analysing the differences of these features, a quality map was elaborated which was then subjected to interpretation, and the identified changes were quantified in detail.

  5. Comparing global alcohol and tobacco control efforts: network formation and evolution in international health governance.

    Science.gov (United States)

    Gneiting, Uwe; Schmitz, Hans Peter

    2016-04-01

    Smoking and drinking constitute two risk factors contributing to the rising burden of non-communicable diseases in low- and middle-income countries. Both issues have gained increased international attention, but tobacco control has made more sustained progress in terms of international and domestic policy commitments, resources dedicated to reducing harm, and reduction of tobacco use in many high-income countries. The research presented here offers insights into why risk factors with comparable levels of harm experience different trajectories of global attention. The analysis focuses particular attention on the role of dedicated global health networks composed of individuals and organizations producing research and engaging in advocacy on a given health problem. Variation in issue characteristics and the policy environment shape the opportunities and challenges of global health networks focused on reducing the burden of disease. What sets the tobacco case apart was the ability of tobacco control advocates to create and maintain a consensus on policy solutions, expand their reach in low- and middle-income countries and combine evidence-based research with advocacy reaching beyond the public health-centered focus of the core network. In contrast, a similar network in the alcohol case struggled with expanding its reach and has yet to overcome divisions based on competing problem definitions and solutions to alcohol harm. The tobacco control network evolved from a group of dedicated individuals to a global coalition of membership-based organizations, whereas the alcohol control network remains at the stage of a collection of dedicated and like-minded individuals. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine © The Author 2016; all rights reserved.

  6. Disentangling the Attention Network Test: Behavioral, Event Related Potentials and neural source analyses.

    Directory of Open Access Journals (Sweden)

    Alejandro eGalvao-Carmona

    2014-10-01

    Full Text Available Background. The study of the attentional system remains a challenge for current neuroscience. The Attention Network Test (ANT was designed to study simultaneously three different attentional networks (alerting, orienting and executive based in subtraction of different experimental conditions. However, some studies recommend caution with these calculations due to the interactions between the attentional networks. In particular, it is highly relevant that several interpretations about attentional impairment have arisen from these calculations in diverse pathologies. Event Related Potentials (ERPs and neural source analysis can be applied to disentangle the relationships between these attentional networks not specifically shown by behavioural measures. Results. This study shows that there is a basic level of alerting (tonic alerting in the no cue condition, represented by a slow negative trend in the ERP trace prior to the onset of the target stimuli. A progressive increase in the CNV amplitude related to the amount of information provided by the cue conditions is also shown. Neural source analysis reveals specific modulations of the CNV related to a task-related expectancy presented in the no cue condition; a late modulation triggered by the central cue condition and probably representing a generic motor preparation; and an early and late modulation for spatial cue condition suggesting specific motor and sensory preactivation. Finally, the first component in the information processing of the target stimuli modulated by the interaction between orienting network and the executive system can be represented by N1. Conclusions. The ANT is useful as a paradigm to study specific attentional mechanisms and their interactions. However, calculation of network effects is based in subtractions with non-comparable experimental conditions, as evidenced by the present data, which can induce misinterpretations in the study of the attentional capacity in human

  7. Something Old, Not Much New, and a Lot Borrowed: Philanthropy, Business, and the Changing Roles of Government in Global Education Policy Networks

    Science.gov (United States)

    Olmedo, Antonio

    2017-01-01

    This paper focuses on the role of governments in contemporary networked political configurations. Such networks constitute policy communities, usually based upon shared conceptions of social problems and their solutions. By enabling social, political, and economic connections at local, regional, national, and international levels, such networks…

  8. Phylogeny, Functional Annotation, and Protein Interaction Network Analyses of the Xenopus tropicalis Basic Helix-Loop-Helix Transcription Factors

    Directory of Open Access Journals (Sweden)

    Wuyi Liu

    2013-01-01

    Full Text Available The previous survey identified 70 basic helix-loop-helix (bHLH proteins, but it was proved to be incomplete, and the functional information and regulatory networks of frog bHLH transcription factors were not fully known. Therefore, we conducted an updated genome-wide survey in the Xenopus tropicalis genome project databases and identified 105 bHLH sequences. Among the retrieved 105 sequences, phylogenetic analyses revealed that 103 bHLH proteins belonged to 43 families or subfamilies with 46, 26, 11, 3, 15, and 4 members in the corresponding supergroups. Next, gene ontology (GO enrichment analyses showed 65 significant GO annotations of biological processes and molecular functions and KEGG pathways counted in frequency. To explore the functional pathways, regulatory gene networks, and/or related gene groups coding for Xenopus tropicalis bHLH proteins, the identified bHLH genes were put into the databases KOBAS and STRING to get the signaling information of pathways and protein interaction networks according to available public databases and known protein interactions. From the genome annotation and pathway analysis using KOBAS, we identified 16 pathways in the Xenopus tropicalis genome. From the STRING interaction analysis, 68 hub proteins were identified, and many hub proteins created a tight network or a functional module within the protein families.

  9. The perspective of sustainability in networked knowledge society: governance, education, ethics

    Directory of Open Access Journals (Sweden)

    Pilar AZNAR MINGUET

    2013-12-01

    Full Text Available This article aims to stimulate thinking about entering the perspective of sustainability in new information societies and knowledge supported by ICTs, and characterized by globalization is far from inclusive. It involves the construction of a global system that promotes the pursuit of environmental quality, social justice and an equitable economy and viable long term. UNESCO has identified three basic ways to get it: governance, education and ethics.Governance can promote equitable social connectivity, changes in patterns of production and consumption and application search and real solutions to the socio-environmental. Education can foster continuing education of those critical, responsible and committed attitudes of respect and harmony with the natural and social environment, international organizations like the OECD, UN and governments through the development of their educational systems, have shaped the competency-based training model, including skills for sustainability are key consider. And all from ethical approaches to guide human capacity to think, act and promote the defense of life on our planet.

  10. Guidelines for governance of data sharing in agri-food networks

    NARCIS (Netherlands)

    Wolfert, J.; Bogaardt, M.J.; Ge, L.; Soma, K.; Verdouw, C.N.

    2017-01-01

    Big Data is becoming a new asset in the agri-food sector including enterprise data from operational systems, sensor data, farm equipment data, etc. Recently, Big Data applications are being implemented to improve farm and chain performance in agri-food networks. Still, many companies are refraining

  11. Building Alternative Agri-Food Networks: Certification, Embeddedness and Agri-Environmental Governance

    Science.gov (United States)

    Higgins, Vaughan; Dibden, Jacqui; Cocklin, Chris

    2008-01-01

    This paper examines the role of certification in alternative agri-food networks (AAFNs), which are "in the process" of building markets for their produce outside conventional supply chains. Drawing upon recent writing on "embeddedness", we argue that certification provides an important focus for exploring the relationship and…

  12. Cross-layer analyses of QoS parameters in wireless sensor networks

    NARCIS (Netherlands)

    Masoum, Alireza; Meratnia, Nirvana; Dilo, Arta; Taghikhaki, Zahra; Havinga, Paul J.M.

    Providing reliable and timely information is one of the important tasks of wireless sensor networks. To this end, recently quality of service (QoS) satisfying end users and matching WSN constrains, has become an important research topic. However, majority of research in this area has overlooked the

  13. Behavioral and Physiological Neural Network Analyses: A Common Pathway toward Pattern Recognition and Prediction

    Science.gov (United States)

    Ninness, Chris; Lauter, Judy L.; Coffee, Michael; Clary, Logan; Kelly, Elizabeth; Rumph, Marilyn; Rumph, Robin; Kyle, Betty; Ninness, Sharon K.

    2012-01-01

    Using 3 diversified datasets, we explored the pattern-recognition ability of the Self-Organizing Map (SOM) artificial neural network as applied to diversified nonlinear data distributions in the areas of behavioral and physiological research. Experiment 1 employed a dataset obtained from the UCI Machine Learning Repository. Data for this study…

  14. Beyond effectuation: Analysing the transformation of business ideas into ventures using actor-network theory"

    DEFF Research Database (Denmark)

    Murdock, Karen; Varnes, Claus Juul

    2018-01-01

    definition of the entrepreneurial endeavour. Originality/value This paper examines how ideas are transformed into business ventures by using the ANT to expand understanding from effectuation theory. This shows that means, for instance, are not given but are co-created by the process of translation....... In addition, which losses are affordable can be determined by the process within which the entrepreneur frames the project and manages to associate allies within and into the network....

  15. Application Layer Definition and Analyses of Controller Area Network Bus for Wire Harness Assembly Machine

    OpenAIRE

    Guo, Hui; Jiang, Ying

    2006-01-01

    With the feature of multi-master bus access, nondestructive contention-based arbitration and flexible configuration, Controller Area Network (CAN) bus is applied into the control system of Wire Harness Assembly Machine (WHAM). To accomplish desired goal, the specific features of the CAN bus is analyzed by compared with other field buses and the functional performances in the CAN bus system of WHAM is discussed. Then the application layer planning of CAN bus for dynamic priority is presented. ...

  16. Some general rules governing huge power networks; Quelques regles generales gouvernant les grands reseaux electriques

    Energy Technology Data Exchange (ETDEWEB)

    Clade, J. [Electricite de France (EDF), 75 - Paris (France)

    2010-12-15

    The very large networks operate on vast territories, on the scale not only of countries, but of continents. Their aim is twofold: transmitting electrical energy from the power plants - nuclear or thermal power plants, hydraulic, wind power plants etc. - to consumption areas (that is the transmission function); pooling the power plants, so as to operate at any time those which are the less expensive (interconnection of energy production) and to guarantee a safe continuous supply to the users (interconnection of power). However, the transmission of electrical energy is more costly than transmission, when possible, of primary energy sources, either fossil fuels or nuclear. When the sources are not chiefly hydraulic, it is pertinent to limit the transmission of electricity by siting the power plants as close as possible to the consumption areas. On the contrary, interconnection may allow significant savings in the way of power plant investments and fuel expenses. Therein is the main economical justification for very large electrical systems and networks, except in cases where distant hydraulic sources are operated. We must then think over large electrical networks mainly as tools for cooperation between power producers, aiming at an electrical supply to customers which is safe, continuous and as inexpensive as possible. (author)

  17. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions

    DEFF Research Database (Denmark)

    Hutton, Brian; Salanti, Georgia; Caldwell, Deborah M

    2015-01-01

    The PRISMA statement is a reporting guideline designed to improve the completeness of reporting of systematic reviews and meta-analyses. Authors have used this guideline worldwide to prepare their reviews for publication. In the past, these reports typically compared 2 treatment alternatives....... With the evolution of systematic reviews that compare multiple treatments, some of them only indirectly, authors face novel challenges for conducting and reporting their reviews. This extension of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement was developed specifically...... to improve the reporting of systematic reviews incorporating network meta-analyses. A group of experts participated in a systematic review, Delphi survey, and face-to-face discussion and consensus meeting to establish new checklist items for this extension statement. Current PRISMA items were also clarified...

  18. Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism.

    Science.gov (United States)

    Hou, Entai; Li, Xian; Liu, Zerong; Zhang, Fuchang; Tian, Zhongmin

    2018-04-01

    Fumarase catalyzes the interconversion of fumarate and l-malate in the tricarboxylic acid cycle. Fumarase insufficiencies were associated with increased levels of fumarate, decreased levels of malate and exacerbated salt-induced hypertension. To gain insights into the metabolism profiles induced by fumarase insufficiency and identify key regulatory metabolites, we applied a GC-MS based metabolomics platform coupled with a network approach to analyze fumarase insufficient human umbilical vein endothelial cells (HUVEC) and negative controls. A total of 24 altered metabolites involved in seven metabolic pathways were identified as significantly altered, and enriched for the biological module of amino acids metabolism. In addition, Pearson correlation network analysis revealed that fumaric acid, l-malic acid, l-aspartic acid, glycine and l-glutamic acid were hub metabolites according to Pagerank based on their three centrality indices. Alanine aminotransferase and glutamate dehydrogenase activities increased significantly in fumarase deficiency HUVEC. These results confirmed that fumarase insufficiency altered amino acid metabolism. The combination of metabolomics and network methods would provide another perspective on expounding the molecular mechanism at metabolomics level. Copyright © 2017 John Wiley & Sons, Ltd.

  19. Using Co-authorship Networks to Map and Analyse Global Neglected Tropical Disease Research with an Affiliation to Germany.

    Science.gov (United States)

    Bender, Max Ernst; Edwards, Suzanne; von Philipsborn, Peter; Steinbeis, Fridolin; Keil, Thomas; Tinnemann, Peter

    2015-12-01

    Research on Neglected Tropical Diseases (NTDs) has increased in recent decades, and significant need-gaps in diagnostic and treatment tools remain. Analysing bibliometric data from published research is a powerful method for revealing research efforts, partnerships and expertise. We aim to identify and map NTD research networks in Germany and their partners abroad to enable an informed and transparent evaluation of German contributions to NTD research. A SCOPUS database search for articles with German author affiliations that were published between 2002 and 2012 was conducted for kinetoplastid and helminth diseases. Open-access tools were used for data cleaning and scientometrics (OpenRefine), geocoding (OpenStreetMaps) and to create (Table2Net), visualise and analyse co-authorship networks (Gephi). From 26,833 publications from around the world that addressed 11 diseases, we identified 1,187 (4.4%) with at least one German author affiliation, and we processed 972 publications for the five most published-about diseases. Of those, we extracted 4,007 individual authors and 863 research institutions to construct co-author networks. The majority of co-authors outside Germany were from high-income countries and Brazil. Collaborations with partners on the African continent remain scattered. NTD research within Germany was distributed among 220 research institutions. We identified strong performers on an individual level by using classic parameters (number of publications, h-index) and social network analysis parameters (betweenness centrality). The research network characteristics varied strongly between diseases. The share of NTD publications with German affiliations is approximately half of its share in other fields of medical research. This finding underlines the need to identify barriers and expand Germany's otherwise strong research activities towards NTDs. A geospatial analysis of research collaborations with partners abroad can support decisions to strengthen

  20. Using Co-authorship Networks to Map and Analyse Global Neglected Tropical Disease Research with an Affiliation to Germany

    Science.gov (United States)

    Bender, Max Ernst; Edwards, Suzanne; von Philipsborn, Peter; Steinbeis, Fridolin; Keil, Thomas; Tinnemann, Peter

    2015-01-01

    Background Research on Neglected Tropical Diseases (NTDs) has increased in recent decades, and significant need-gaps in diagnostic and treatment tools remain. Analysing bibliometric data from published research is a powerful method for revealing research efforts, partnerships and expertise. We aim to identify and map NTD research networks in Germany and their partners abroad to enable an informed and transparent evaluation of German contributions to NTD research. Methodology/Principal Findings A SCOPUS database search for articles with German author affiliations that were published between 2002 and 2012 was conducted for kinetoplastid and helminth diseases. Open-access tools were used for data cleaning and scientometrics (OpenRefine), geocoding (OpenStreetMaps) and to create (Table2Net), visualise and analyse co-authorship networks (Gephi). From 26,833 publications from around the world that addressed 11 diseases, we identified 1,187 (4.4%) with at least one German author affiliation, and we processed 972 publications for the five most published-about diseases. Of those, we extracted 4,007 individual authors and 863 research institutions to construct co-author networks. The majority of co-authors outside Germany were from high-income countries and Brazil. Collaborations with partners on the African continent remain scattered. NTD research within Germany was distributed among 220 research institutions. We identified strong performers on an individual level by using classic parameters (number of publications, h-index) and social network analysis parameters (betweenness centrality). The research network characteristics varied strongly between diseases. Conclusions/Significance The share of NTD publications with German affiliations is approximately half of its share in other fields of medical research. This finding underlines the need to identify barriers and expand Germany’s otherwise strong research activities towards NTDs. A geospatial analysis of research

  1. Privatising Education, Privatising Education Policy, Privatising Educational Research: Network Governance and the "Competition State"

    Science.gov (United States)

    Ball, Stephen J.

    2009-01-01

    This paper explores some particular aspects of the privatisation of public sector education, mapping and analysing the participation of education businesses in a whole range of public sector education services both in the UK and overseas. It addresses some of the types of privatisation(s) which are taking place "of", "in" and…

  2. Beyond effectuation: Analysing the transformation of business ideas into ventures using actor-network theory"

    DEFF Research Database (Denmark)

    Murdock, Karen; Varnes, Claus Juul

    2018-01-01

    , affordable loss, and other key concepts from this theoretical perspective. Drawing upon actor-network theory (ANT), this study demonstrates how different framing and support devices implicate different human and non-human actors in changing interpositions within the entrepreneurial process. Design...... definition of the entrepreneurial endeavour. Originality/value This paper examines how ideas are transformed into business ventures by using the ANT to expand understanding from effectuation theory. This shows that means, for instance, are not given but are co-created by the process of translation...

  3. EDENetworks: a user-friendly software to build and analyse networks in biogeography, ecology and population genetics.

    Science.gov (United States)

    Kivelä, Mikko; Arnaud-Haond, Sophie; Saramäki, Jari

    2015-01-01

    The recent application of graph-based network theory analysis to biogeography, community ecology and population genetics has created a need for user-friendly software, which would allow a wider accessibility to and adaptation of these methods. EDENetworks aims to fill this void by providing an easy-to-use interface for the whole analysis pipeline of ecological and evolutionary networks starting from matrices of species distributions, genotypes, bacterial OTUs or populations characterized genetically. The user can choose between several different ecological distance metrics, such as Bray-Curtis or Sorensen distance, or population genetic metrics such as FST or Goldstein distances, to turn the raw data into a distance/dissimilarity matrix. This matrix is then transformed into a network by manual or automatic thresholding based on percolation theory or by building the minimum spanning tree. The networks can be visualized along with auxiliary data and analysed with various metrics such as degree, clustering coefficient, assortativity and betweenness centrality. The statistical significance of the results can be estimated either by resampling the original biological data or by null models based on permutations of the data. © 2014 John Wiley & Sons Ltd.

  4. A multinomial logit model-Bayesian network hybrid approach for driver injury severity analyses in rear-end crashes.

    Science.gov (United States)

    Chen, Cong; Zhang, Guohui; Tarefder, Rafiqul; Ma, Jianming; Wei, Heng; Guan, Hongzhi

    2015-07-01

    Rear-end crash is one of the most common types of traffic crashes in the U.S. A good understanding of its characteristics and contributing factors is of practical importance. Previously, both multinomial Logit models and Bayesian network methods have been used in crash modeling and analysis, respectively, although each of them has its own application restrictions and limitations. In this study, a hybrid approach is developed to combine multinomial logit models and Bayesian network methods for comprehensively analyzing driver injury severities in rear-end crashes based on state-wide crash data collected in New Mexico from 2010 to 2011. A multinomial logit model is developed to investigate and identify significant contributing factors for rear-end crash driver injury severities classified into three categories: no injury, injury, and fatality. Then, the identified significant factors are utilized to establish a Bayesian network to explicitly formulate statistical associations between injury severity outcomes and explanatory attributes, including driver behavior, demographic features, vehicle factors, geometric and environmental characteristics, etc. The test results demonstrate that the proposed hybrid approach performs reasonably well. The Bayesian network reference analyses indicate that the factors including truck-involvement, inferior lighting conditions, windy weather conditions, the number of vehicles involved, etc. could significantly increase driver injury severities in rear-end crashes. The developed methodology and estimation results provide insights for developing effective countermeasures to reduce rear-end crash injury severities and improve traffic system safety performance. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Prediction and validation of gene-disease associations using methods inspired by social network analyses.

    Directory of Open Access Journals (Sweden)

    U Martin Singh-Blom

    Full Text Available Correctly identifying associations of genes with diseases has long been a goal in biology. With the emergence of large-scale gene-phenotype association datasets in biology, we can leverage statistical and machine learning methods to help us achieve this goal. In this paper, we present two methods for predicting gene-disease associations based on functional gene associations and gene-phenotype associations in model organisms. The first method, the Katz measure, is motivated from its success in social network link prediction, and is very closely related to some of the recent methods proposed for gene-disease association inference. The second method, called Catapult (Combining dATa Across species using Positive-Unlabeled Learning Techniques, is a supervised machine learning method that uses a biased support vector machine where the features are derived from walks in a heterogeneous gene-trait network. We study the performance of the proposed methods and related state-of-the-art methods using two different evaluation strategies, on two distinct data sets, namely OMIM phenotypes and drug-target interactions. Finally, by measuring the performance of the methods using two different evaluation strategies, we show that even though both methods perform very well, the Katz measure is better at identifying associations between traits and poorly studied genes, whereas Catapult is better suited to correctly identifying gene-trait associations overall [corrected].

  6. Prevalence of hyperlipidemia in Shanxi Province, China and application of Bayesian networks to analyse its related factors.

    Science.gov (United States)

    Pan, Jinhua; Ren, Zeping; Li, Wenhan; Wei, Zhen; Rao, Huaxiang; Ren, Hao; Zhang, Zhuang; Song, Weimei; He, Yuling; Li, Chenglian; Yang, Xiaojuan; Chen, LiMin; Qiu, Lixia

    2018-02-28

    This study aimed to obtain the prevalence of hyperlipidemia and its related factors in Shanxi Province, China using multivariate logistic regression analysis and tabu search-based Bayesian networks (BNs). A multi-stage stratified random sampling method was adopted to obtain samples among the general population aged 18 years or above. The prevalence of hyperlipidemia in Shanxi Province was 42.6%. Multivariate logistic regression analysis indicated that gender, age, region, occupation, vegetable intake level, physical activity, body mass index, central obesity, hypertension, and diabetes mellitus are associated with hyperlipidemia. BNs were used to find connections between those related factors and hyperlipidemia, which were established by a complex network structure. The results showed that BNs can not only be used to find out the correlative factors of hyperlipidemia but also to analyse how these factors affect hyperlipidemia and their interrelationships, which is consistent with practical theory, is superior to logistic regression and has better application prospects.

  7. Evaluation of high-resolution precipitation analyses using a dense station network

    OpenAIRE

    A. Kann; I. Meirold-Mautner; F. Schmid; G. Kirchengast; J. Fuchsberger; V. Meyer; L. Tüchler; B. Bica

    2015-01-01

    The ability of radar–rain gauge merging algorithms to precisely analyse convective precipitation patterns is of high interest for many applications, e.g. hydrological modelling, thunderstorm warnings, and, as a reference, to spatially validate numerical weather prediction models. However, due to drawbacks of methods like cross-validation and due to the limited availability of reference data sets on high temporal and spatial scales, an adequate validation is usually hardly po...

  8. The Worldwide Interplanetary Scintillation (IPS) Stations (WIPSS) Network October 2016 Observing Campaign: Initial WIPSS Data Analyses

    Science.gov (United States)

    Bisi, M. M.; Fallows, R. A.; Jackson, B. V.; Tokumaru, M.; Gonzalez-Esparza, A.; Morgan, J.; Chashei, I. V.; Mejia-Ambriz, J.; Tyul'bashev, S. A.; Manoharan, P. K.; De la Luz, V.; Aguilar-Rodriguez, E.; Yu, H. S.; Barnes, D.; Chang, O.; Odstrcil, D.; Fujiki, K.; Shishov, V.

    2017-12-01

    Interplanetary Scintillation (IPS) allows for the determination of velocity and a proxy for plasma density to be made throughout the corona and inner heliosphere. Where sufficient observations are undertaken, the results can be used as input to the University of California, San Diego (UCSD) three-dimensional (3-D) time-dependent tomography suite to allow for the full 3-D reconstruction of both velocity and density throughout the inner heliosphere. By combining IPS results from multiple observing locations around the planet, we can increase both the temporal and spatial coverage across the whole of the inner heliosphere and hence improve forecast capability. During October 2016, a unique opportunity arose whereby the European-based LOw Frequency ARray (LOFAR) radio telescope was used to make nearly four weeks of continuous observations of IPS as a heliospheric space-weather trial campaign. This was expanded into a global effort to include observations of IPS from the Murchison Widefield Array (MWA) in Western Australia and many more observations from various IPS-dedicated WIPSS Network systems. LOFAR is a next-generation low-frequency radio interferometer capable of observing in the radio frequency range 10-250 MHz, nominally with up to 80 MHz bandwidth at a time. MWA in Western Australia is capable of observing in the 80-300 MHz frequency range nominally using up to 32 MHz of bandwidth. IPS data from LOFAR, ISEE, the MEXican Array Radio Telescope (MEXART), and, where possible, other WIPSS Network systems (such as LPI-BSA and Ooty), will be used in this study and we will present some initial findings for these data sets. We also make a first attempt at the 3-D reconstruction of multiple pertinent WIPSS results in the UCSD tomography. We will also try to highlight some of the potential future tools that make LOFAR a very unique system to be able to test and validate a whole plethora of IPS analysis methods with the same set of IPS data.

  9. Governance and networks for health co-benefits of climate change mitigation: Lessons from two Indian cities.

    Science.gov (United States)

    Puppim de Oliveira, Jose A; Doll, Christopher N H

    2016-12-01

    Health has been the main driver for many urban environmental interventions, particularly in cases of significant health problems linked to poor urban environmental conditions. This paper examines empirically the links between climate change mitigation and health in urban areas, when health is the main driver for improvements. The paper aims to understand how systems of urban governance can enable or prevent the creation of health outcomes via continuous improvements in the environmental conditions in a city. The research draws on cases from two Indian cities where initiatives were undertaken in different sectors: Surat (waste) and Delhi (transportation). Using the literature on network effectiveness as an analytical framework, the paper compares the cases to identify the possible ways to strengthen the governance and policy making process in the urban system so that each intervention can intentionally realize multiple impacts for both local health and climate change mitigation in the long term as well as factors that may pose a threat to long-term progress and revert back to the previous situation after initial achievements. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. On Governance, Embedding and Marketing: Reflections on the Construction of Alternative Sustainable Food Networks.

    Science.gov (United States)

    Roep, Dirk; Wiskerke, Johannes S C

    Based on the reconstruction of the development of 14 food supply chain initiatives in 7 European countries, we developed a conceptual framework that demonstrates that the process of increasing the sustainability of food supply chains is rooted in strategic choices regarding governance , embedding, and marketing and in the coordination of these three dimensions that are inextricably interrelated. The framework also shows that when seeking to further develop an initiative (e.g., through scaling up or product diversification) these interrelations need continuous rebalancing. We argue that the framework can serve different purposes: it can be used as an analytical tool by researchers studying food supply chain dynamics, as a policy tool by policymakers that want to support the development of sustainable food supply chains, and as a reflexive tool by practitioners and their advisors to help them to position themselves, develop a clear strategy, find the right allies, develop their skills, and build the capacities that they need. In this paper, we elaborate upon the latter function of the framework and illustrate this briefly with empirical evidence from three of the initiatives that we studied.

  11. Replicated landscape genetic and network analyses reveal wide variation in functional connectivity for American pikas.

    Science.gov (United States)

    Castillo, Jessica A; Epps, Clinton W; Jeffress, Mackenzie R; Ray, Chris; Rodhouse, Thomas J; Schwalm, Donelle

    2016-09-01

    Landscape connectivity is essential for maintaining viable populations, particularly for species restricted to fragmented habitats or naturally arrayed in metapopulations and facing rapid climate change. The importance of assessing both structural connectivity (physical distribution of favorable habitat patches) and functional connectivity (how species move among habitat patches) for managing such species is well understood. However, the degree to which functional connectivity for a species varies among landscapes, and the resulting implications for conservation, have rarely been assessed. We used a landscape genetics approach to evaluate resistance to gene flow and, thus, to determine how landscape and climate-related variables influence gene flow for American pikas (Ochotona princeps) in eight federally managed sites in the western United States. We used empirically derived, individual-based landscape resistance models in conjunction with predictive occupancy models to generate patch-based network models describing functional landscape connectivity. Metareplication across landscapes enabled identification of limiting factors for dispersal that would not otherwise have been apparent. Despite the cool microclimates characteristic of pika habitat, south-facing aspects consistently represented higher resistance to movement, supporting the previous hypothesis that exposure to relatively high temperatures may limit dispersal in American pikas. We found that other barriers to dispersal included areas with a high degree of topographic relief, such as cliffs and ravines, as well as streams and distances greater than 1-4 km depending on the site. Using the empirically derived network models of habitat patch connectivity, we identified habitat patches that were likely disproportionately important for maintaining functional connectivity, areas in which habitat appeared fragmented, and locations that could be targeted for management actions to improve functional connectivity

  12. Comparative clinical effectiveness of management strategies for sciatica: systematic review and network meta-analyses.

    Science.gov (United States)

    Lewis, Ruth A; Williams, Nefyn H; Sutton, Alex J; Burton, Kim; Din, Nafees Ud; Matar, Hosam E; Hendry, Maggie; Phillips, Ceri J; Nafees, Sadia; Fitzsimmons, Deborah; Rickard, Ian; Wilkinson, Clare

    2015-06-01

    There are numerous treatment approaches for sciatica. Previous systematic reviews have not compared all these strategies together. To compare the clinical effectiveness of different treatment strategies for sciatica simultaneously. Systematic review and network meta-analysis. We searched 28 electronic databases and online trial registries, along with bibliographies of previous reviews for comparative studies evaluating any intervention to treat sciatica in adults, with outcome data on global effect or pain intensity. Network meta-analysis methods were used to simultaneously compare all treatment strategies and allow indirect comparisons of treatments between studies. The study was funded by the UK National Institute for Health Research Health Technology Assessment program; there are no potential conflict of interests. We identified 122 relevant studies; 90 were randomized controlled trials (RCTs) or quasi-RCTs. Interventions were grouped into 21 treatment strategies. Internal and external validity of included studies was very low. For overall recovery as the outcome, compared with inactive control or conventional care, there was a statistically significant improvement following disc surgery, epidural injections, nonopioid analgesia, manipulation, and acupuncture. Traction, percutaneous discectomy, and exercise therapy were significantly inferior to epidural injections or surgery. For pain as the outcome, epidural injections and biological agents were significantly better than inactive control, but similar findings for disc surgery were not statistically significant. Biological agents were significantly better for pain reduction than bed rest, nonopioids, and opioids. Opioids, education/advice alone, bed rest, and percutaneous discectomy were inferior to most other treatment strategies; although these findings represented large effects, they were statistically equivocal. For the first time, many different treatment strategies for sciatica have been compared in the

  13. A Network of Local and Redundant Gene Regulation Governs Arabidopsis Seed Maturation

    Science.gov (United States)

    To, Alexandra; Valon, Christiane; Savino, Gil; Guilleminot, Jocelyne; Devic, Martine; Giraudat, Jérôme; Parcy, François

    2006-01-01

    In Arabidopsis thaliana, four major regulators (ABSCISIC ACID INSENSITIVE3 [ABI3], FUSCA3 [FUS3], LEAFY COTYLEDON1 [LEC1], and LEC2) control most aspects of seed maturation, such as accumulation of storage compounds, cotyledon identity, acquisition of desiccation tolerance, and dormancy. The molecular basis for complex genetic interactions among these regulators is poorly understood. By analyzing ABI3 and FUS3 expression in various single, double, and triple maturation mutants, we have identified multiple regulatory links among all four genes. We found that one of the major roles of LEC2 was to upregulate FUS3 and ABI3. The lec2 mutation is responsible for a dramatic decrease in ABI3 and FUS3 expression, and most lec2 phenotypes can be rescued by ABI3 or FUS3 constitutive expression. In addition, ABI3 and FUS3 positively regulate themselves and each other, thereby forming feedback loops essential for their sustained and uniform expression in the embryo. Finally, LEC1 also positively regulates ABI3 and FUS3 in the cotyledons. Most of the genetic controls discovered were found to be local and redundant, explaining why they had previously been overlooked. This works establishes a genetic framework for seed maturation, organizing the key regulators of this process into a hierarchical network. In addition, it offers a molecular explanation for the puzzling variable features of lec2 mutant embryos. PMID:16731585

  14. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer.

    Science.gov (United States)

    Du, Zhou; Sun, Tong; Hacisuleyman, Ezgi; Fei, Teng; Wang, Xiaodong; Brown, Myles; Rinn, John L; Lee, Mary Gwo-Shu; Chen, Yiwen; Kantoff, Philip W; Liu, X Shirley

    2016-03-15

    Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for microRNA binding to protein-coding transcripts. However, the prevalence, functional significance and targets of lncRNA-mediated sponge regulation of cancer are mostly unknown. Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. We confirm the tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. Surprisingly, one of the two lncRNAs, TUG1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcriptional regulation, suggesting its sub-cellular localization-dependent function. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA.

  15. A Microsoft-Excel-based tool for running and critically appraising network meta-analyses--an overview and application of NetMetaXL.

    Science.gov (United States)

    Brown, Stephen; Hutton, Brian; Clifford, Tammy; Coyle, Doug; Grima, Daniel; Wells, George; Cameron, Chris

    2014-09-29

    The use of network meta-analysis has increased dramatically in recent years. WinBUGS, a freely available Bayesian software package, has been the most widely used software package to conduct network meta-analyses. However, the learning curve for WinBUGS can be daunting, especially for new users. Furthermore, critical appraisal of network meta-analyses conducted in WinBUGS can be challenging given its limited data manipulation capabilities and the fact that generation of graphical output from network meta-analyses often relies on different software packages than the analyses themselves. We developed a freely available Microsoft-Excel-based tool called NetMetaXL, programmed in Visual Basic for Applications, which provides an interface for conducting a Bayesian network meta-analysis using WinBUGS from within Microsoft Excel. . This tool allows the user to easily prepare and enter data, set model assumptions, and run the network meta-analysis, with results being automatically displayed in an Excel spreadsheet. It also contains macros that use NetMetaXL's interface to generate evidence network diagrams, forest plots, league tables of pairwise comparisons, probability plots (rankograms), and inconsistency plots within Microsoft Excel. All figures generated are publication quality, thereby increasing the efficiency of knowledge transfer and manuscript preparation. We demonstrate the application of NetMetaXL using data from a network meta-analysis published previously which compares combined resynchronization and implantable defibrillator therapy in left ventricular dysfunction. We replicate results from the previous publication while demonstrating result summaries generated by the software. Use of the freely available NetMetaXL successfully demonstrated its ability to make running network meta-analyses more accessible to novice WinBUGS users by allowing analyses to be conducted entirely within Microsoft Excel. NetMetaXL also allows for more efficient and transparent

  16. Clinical governance network for clinical audit to improve quality in epithelial ovarian cancer management.

    Science.gov (United States)

    Mandato, Vincenzo Dario; Abrate, Martino; De Iaco, Pierandrea; Pirillo, Debora; Ciarlini, Gino; Leoni, Maurizio; Comerci, Giuseppe; Ventura, Alessandro; Lenzi, Bruno; Amadori, Andrea; Rosati, Federica; Martinello, Ruby; De Palma, Rossana; Ventura, Chiara; Belotti, Laura Maria Beatrice; Formisano, Debora; La Sala, Giovanni Battista

    2013-03-31

    Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Several hospitals throughout the region provide primary treatment for these patients and it is well know that treatment quality is correlated to the hospital that delivers. The aim of this study was to investigate the management and treatment of EOC in a Region of the North Italy (Emilia-Romagna, Italy). A multidisciplinary group made up of 11 physicians and 3 biostatisticians was formed in 2009 to perform clinical audits in order to identify quality indicators and to develop Region-wide workup in accordance with the principles of evidence-based medicine (EBM). The rationale was that, by setting up an oncogynecology network so as to achieve the best clinical practice, critical points would decrease or even be eliminated. Analysis of cases was based on the review of the medical records. 614 EOC patients treated between 2007 and 2008 were identified. We found only 2 high-volume hospitals (≥ 21 patients/year), 3 medium-volume hospitals (11-20 operated patients/year), and 7 low-volume hospitals (≤ 10 operated patients /year). Only 222 patients (76.3%) had a histological diagnosis, FIGO surgical staging was reported only in 206 patients (70.9%) but not all standard surgical procedures were always performed, residual disease were not reported in all patients. No standard number of neoadjuvant chemotherapy cycles was observed. The differences in terms of treatments provided led the multidisciplinary group to identify reference centers, to promote centralization, to ensure uniform and adequate treatment to patients treated in regional centers and to promote a new audit involving all regional hospitals to a complete review of the all the EOC patients.

  17. Province wide clinical governance network for clinical audit for quality improvement in endometrial cancer management.

    Science.gov (United States)

    Mandato, Vincenzo Dario; Formisano, Debora; Pirillo, Debora; Ciarlini, Gino; Cerami, Lillo Bruno; Ventura, Alessandro; Spreafico, Lorenzo; Palmieri, Tamara; La Sala, Giovanni Battista; Abrate, Martino

    2012-01-01

    According to the hub-and-spoke model introduced in the Provincial Healthcare System of Reggio Emilia, early endometrial cancer is treated in peripheral low-volume hospitals (spokes) by general gynecologist, whereas more complex cancers are treated by gynecological oncologists at the main hospital (hub). To guarantee a uniformly high standard of care to all patients with endometrial cancer treated in hub and spoke hospitals of Reggio Emilia Province. The specialists of the 5 hospitals of Reggio Emilia Province instituted an inter hospital and multidisciplinary oncology group to write common and shared guidelines based on evidence-based medicine through the use of clinical audit. They valued the process indicators before and after guidelines introduction identifying the site of improvement and verifying the standard achievement. Diagnostic hysteroscopy use increased significantly from preguideline period, 53%, to postguideline period, 74%. Magnetic resonance use and accuracy increased significantly from preguideline to postguideline periods: 8.1% to 35.3% and 37.3% to 74.7%, respectively. Laparoscopy use increased from 1.6% (preguideline) to 18.6 (postguideline). Early surgical complications decreased from 16% (preguideline) to 9% (postguideline). Radiotherapy use increased from 14.% (preguideline) to 32.3% (postguideline). It is possible for a provincial oncology group to build an oncology network providing an improvement in the assistance of patients with endometrial cancer through the use of clinical audit. Clinical audit made it possible to obtain the full attendance of specialists of various disciplines involved in the treatment of endometrial cancer to optimize response time schematizing process.

  18. Comparative ultrastructural analyses of platelets and fibrin networks using the murine model of asthma.

    Science.gov (United States)

    Pretorius, E; Ekpo, O E; Smit, E

    2007-10-01

    The murine Balb/c asthma model has been used successfully for a number of in vivo immunological applications and for testing novel therapeutics, and it is a reliable, clinically relevant facsimile of the human disease. Here we investigate whether this model can be used to study other components of the human body, e.g. ultrastructure. In particular, we investigate the effect of the phytomedicine Euphorbia hirta (used to treat asthma), on the ultrastructure of fibrin as well as platelets, cellular structures that both play an important role in the coagulation process. Hydrocortisone is used as positive control. Ultrastructure of the fibrin networks and platelets of control mice were compared to mice that were asthmatic, treated with two concentrations of hydrocortisone and one concentration of the plant material. Results indicate control mice possess major, thick fibers and minor thin fibers as well as tight round platelet aggregates with typical pseudopodia formation. Minor fibers of asthmatic mice have a netlike appearance covering the major fibers, while the platelets seem to form loosely connected, granular aggregates. Both concentrations of hydrocortisone make the fibrin more fragile and that platelet morphology changes form a tight platelet aggregate to a more granular aggregate not closely fused to each other. We conclude that E. hirta does not impact on the fragility of the fibrin and that it prevents the minor fibers to form the dense netlike layer over the major fibers, as is seen in untreated asthmatic mice. This ultrastructural morphology might give us better insight into asthma and the possible new treatment regimes.

  19. Association analyses of the MAS-QTL data set using grammar, principal components and Bayesian network methodologies

    Directory of Open Access Journals (Sweden)

    Karacaören Burak

    2011-05-01

    Full Text Available Abstract Background It has been shown that if genetic relationships among individuals are not taken into account for genome wide association studies, this may lead to false positives. To address this problem, we used Genome-wide Rapid Association using Mixed Model and Regression and principal component stratification analyses. To account for linkage disequilibrium among the significant markers, principal components loadings obtained from top markers can be included as covariates. Estimation of Bayesian networks may also be useful to investigate linkage disequilibrium among SNPs and their relation with environmental variables. For the quantitative trait we first estimated residuals while taking polygenic effects into account. We then used a single SNP approach to detect the most significant SNPs based on the residuals and applied principal component regression to take linkage disequilibrium among these SNPs into account. For the categorical trait we used principal component stratification methodology to account for background effects. For correction of linkage disequilibrium we used principal component logit regression. Bayesian networks were estimated to investigate relationship among SNPs. Results Using the Genome-wide Rapid Association using Mixed Model and Regression and principal component stratification approach we detected around 100 significant SNPs for the quantitative trait (p Conclusions GRAMMAR could efficiently incorporate the information regarding random genetic effects. Principal component stratification should be cautiously used with stringent multiple hypothesis testing correction to correct for ancestral stratification and association analyses for binary traits when there are systematic genetic effects such as half sib family structures. Bayesian networks are useful to investigate relationships among SNPs and environmental variables.

  20. Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network and pathway analyses

    Directory of Open Access Journals (Sweden)

    Lisette J. A. Kogelman

    2014-07-01

    Full Text Available Obesity is a complex condition with world-wide exponentially rising prevalence rates, linked with severe diseases like Type 2 Diabetes. Economic and welfare consequences have led to a raised interest in a better understanding of the biological and genetic background. To date, whole genome investigations focusing on single genetic variants have achieved limited success, and the importance of including genetic interactions is becoming evident. Here, the aim was to perform an integrative genomic analysis in an F2 pig resource population that was constructed with an aim to maximize genetic variation of obesity-related phenotypes and genotyped using the 60K SNP chip. Firstly, Genome Wide Association (GWA analysis was performed on the Obesity Index to locate candidate genomic regions that were further validated using combined Linkage Disequilibrium Linkage Analysis and investigated by evaluation of haplotype blocks. We built Weighted Interaction SNP Hub (WISH and differentially wired (DW networks using genotypic correlations amongst obesity-associated SNPs resulting from GWA analysis. GWA results and SNP modules detected by WISH and DW analyses were further investigated by functional enrichment analyses. The functional annotation of SNPs revealed several genes associated with obesity, e.g. NPC2 and OR4D10. Moreover, gene enrichment analyses identified several significantly associated pathways, over and above the GWA study results, that may influence obesity and obesity related diseases, e.g. metabolic processes. WISH networks based on genotypic correlations allowed further identification of various gene ontology terms and pathways related to obesity and related traits, which were not identified by the GWA study. In conclusion, this is the first study to develop a (genetic obesity index and employ systems genetics in a porcine model to provide important insights into the complex genetic architecture associated with obesity and many biological pathways

  1. Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis.

    Science.gov (United States)

    Catalá-López, Ferrán; Alonso-Arroyo, Adolfo; Hutton, Brian; Aleixandre-Benavent, Rafael; Moher, David

    2014-01-29

    Research collaboration contributes to the advancement of knowledge by exploiting the results of scientific efforts more efficiently, but the global patterns of collaboration on meta-analysis are unknown. The purpose of this research was to describe and characterize the global collaborative patterns in meta-analyses of randomized trials published in high impact factor medical journals over the past three decades. This was a cross-sectional, social network analysis. We searched PubMed for relevant meta-analyses of randomized trials published up to December 2012. We selected meta-analyses (including at least randomized trials as primary evidence source) published in the top seven high impact factor general medical journals (according to Journal Citation Reports 2011): The New England Journal of Medicine, The Lancet, the BMJ, JAMA, Annals of Internal Medicine, Archives of Internal Medicine (now renamed JAMA Internal Medicine), and PLoS Medicine. Opinion articles, conceptual papers, narrative reviews, reviews without meta-analysis, reviews of reviews, and other study designs were excluded. Overall, we included 736 meta-analyses, in which 3,178 authors, 891 institutions, and 51 countries participated. The BMJ was the journal that published the greatest number of articles (39%), followed by The Lancet (18%), JAMA (15%) and the Archives of Internal Medicine (15%). The USA, the UK, and Canada headed the absolute global productivity ranking in number of papers. The 64 authors and the 39 institutions with the highest publication rates were identified. We also found 82 clusters of authors (one group with 55 members and one group with 54 members) and 19 clusters of institutions (one major group with 76 members). The most prolific authors were mainly affiliated with the University of Oxford (UK), McMaster University (Canada), and the University of Bern (Switzerland). Our analysis identified networks of authors, institutions and countries publishing meta-analyses of randomized

  2. Health care networks implementation and regional governance challenges in the Legal Amazon Region: an analysis of the QualiSUS-Rede Project.

    Science.gov (United States)

    Casanova, Angela Oliveira; Cruz, Marly Marques; Giovanella, Ligia; Alves, Glaydes Dos Reis; Cardoso, Gisela Cordeiro Pereira

    2017-04-01

    This paper aims to analyze the potential, limits and challenges of regional governance in the implementation process of health care networks in three Brazilian regions: Alto Solimões (Amazonas), Belém (Pará) and an interstate region comprising Tocantins, Pará and Maranhão states (Topama). The study is based on the evaluation study on the implementation of the Quality Health Care Network Development and Improvement Project (QualiSUS-Rede). This is a qualitative multiple case study with the analysis of official documents and use of semi-structured interviews with key stakeholders conducted from July to December 2014. Governance review encompassed three components: stakeholders involved, especially local steering groups and their regional coordination capacity; strategies used for strengthening regional governance, anchored on the intervention's modeling; and implementation of local health care networks. Results point that the regional managing commissions were the main governance strategy and that the QualiSUS-Rede Project strengthened regional governance and integration differently in every case, depending on stakeholders' administration and consensus capacity on regional and political priorities.

  3. Public Discourses on Education Governance and Social Integration and Exclusion: Analyses of Policy Texts in European Contexts. Uppsala Reports on Education.

    Science.gov (United States)

    Lindblad, Sverker, Ed.; Popkewitz, Thomas S., Ed.

    This volume is a collection of public discourses on European education governance, and social integration and exclusion, focusing in particular on changes in education governance in Finland, Germany, Greece, Iceland, Portugal, Spain, Sweden, England, and Scotland. Ten chapters include: (1) "Introduction: Research Problematics and…

  4. Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network and pathway analyses

    DEFF Research Database (Denmark)

    Kogelman, Lisette; Pant, Sameer Dinkar; Fredholm, Merete

    2014-01-01

    Obesity is a complex condition with world-wide exponentially rising prevalence rates, linked with severe diseases like Type 2 Diabetes. Economic and welfare consequences have led to a raised interest in a better understanding of the biological and genetic background. To date, whole genome...... of obesity-related phenotypes and genotyped using the 60K SNP chip. Firstly, Genome Wide Association (GWA) analysis was performed on the Obesity Index to locate candidate genomic regions that were further validated using combined Linkage Disequilibrium Linkage Analysis and investigated by evaluation...... of haplotype blocks. We built Weighted Interaction SNP Hub (WISH) and differentially wired (DW) networks using genotypic correlations amongst obesity-associated SNPs resulting from GWA analysis. GWA results and SNP modules detected by WISH and DW analyses were further investigated by functional enrichment...

  5. Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks

    Science.gov (United States)

    Glicksberg, Benjamin S.; Li, Li; Badgeley, Marcus A.; Shameer, Khader; Kosoy, Roman; Beckmann, Noam D.; Pho, Nam; Hakenberg, Jörg; Ma, Meng; Ayers, Kristin L.; Hoffman, Gabriel E.; Dan Li, Shuyu; Schadt, Eric E.; Patel, Chirag J.; Chen, Rong; Dudley, Joel T.

    2016-01-01

    Motivation: Underrepresentation of racial groups represents an important challenge and major gap in phenomics research. Most of the current human phenomics research is based primarily on European populations; hence it is an important challenge to expand it to consider other population groups. One approach is to utilize data from EMR databases that contain patient data from diverse demographics and ancestries. The implications of this racial underrepresentation of data can be profound regarding effects on the healthcare delivery and actionability. To the best of our knowledge, our work is the first attempt to perform comparative, population-scale analyses of disease networks across three different populations, namely Caucasian (EA), African American (AA) and Hispanic/Latino (HL). Results: We compared susceptibility profiles and temporal connectivity patterns for 1988 diseases and 37 282 disease pairs represented in a clinical population of 1 025 573 patients. Accordingly, we revealed appreciable differences in disease susceptibility, temporal patterns, network structure and underlying disease connections between EA, AA and HL populations. We found 2158 significantly comorbid diseases for the EA cohort, 3265 for AA and 672 for HL. We further outlined key disease pair associations unique to each population as well as categorical enrichments of these pairs. Finally, we identified 51 key ‘hub’ diseases that are the focal points in the race-centric networks and of particular clinical importance. Incorporating race-specific disease comorbidity patterns will produce a more accurate and complete picture of the disease landscape overall and could support more precise understanding of disease relationships and patient management towards improved clinical outcomes. Contacts: rong.chen@mssm.edu or joel.dudley@mssm.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307606

  6. Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks.

    Science.gov (United States)

    Glicksberg, Benjamin S; Li, Li; Badgeley, Marcus A; Shameer, Khader; Kosoy, Roman; Beckmann, Noam D; Pho, Nam; Hakenberg, Jörg; Ma, Meng; Ayers, Kristin L; Hoffman, Gabriel E; Dan Li, Shuyu; Schadt, Eric E; Patel, Chirag J; Chen, Rong; Dudley, Joel T

    2016-06-15

    Underrepresentation of racial groups represents an important challenge and major gap in phenomics research. Most of the current human phenomics research is based primarily on European populations; hence it is an important challenge to expand it to consider other population groups. One approach is to utilize data from EMR databases that contain patient data from diverse demographics and ancestries. The implications of this racial underrepresentation of data can be profound regarding effects on the healthcare delivery and actionability. To the best of our knowledge, our work is the first attempt to perform comparative, population-scale analyses of disease networks across three different populations, namely Caucasian (EA), African American (AA) and Hispanic/Latino (HL). We compared susceptibility profiles and temporal connectivity patterns for 1988 diseases and 37 282 disease pairs represented in a clinical population of 1 025 573 patients. Accordingly, we revealed appreciable differences in disease susceptibility, temporal patterns, network structure and underlying disease connections between EA, AA and HL populations. We found 2158 significantly comorbid diseases for the EA cohort, 3265 for AA and 672 for HL. We further outlined key disease pair associations unique to each population as well as categorical enrichments of these pairs. Finally, we identified 51 key 'hub' diseases that are the focal points in the race-centric networks and of particular clinical importance. Incorporating race-specific disease comorbidity patterns will produce a more accurate and complete picture of the disease landscape overall and could support more precise understanding of disease relationships and patient management towards improved clinical outcomes. rong.chen@mssm.edu or joel.dudley@mssm.edu Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

  7. Towards a fluid and multiscalar governance of extractive resources ...

    African Journals Online (AJOL)

    Political geographies of oil investigate extractive value chains with an emphasis on governance and scales, analysing the role that territories and especially spatial networks play in these dynamics. While underlining the limits and gaps of territorial governance, as it is nowadays theorized and used in the academic literature, ...

  8. Analyses and optimization of Lee propagation model for LoRa 868 MHz network deployments in urban areas

    Directory of Open Access Journals (Sweden)

    Dobrilović Dalibor

    2017-01-01

    Full Text Available In the recent period, fast ICT expansion and rapid appearance of new technologies raised the importance of fast and accurate planning and deployment of emerging communication technologies, especially wireless ones. In this paper is analyzed possible usage of Lee propagation model for planning, design and management of networks based on LoRa 868MHz technology. LoRa is wireless technology which can be deployed in various Internet of Things and Smart City scenarios in urban areas. The analyses are based on comparison of field measurements with model calculations. Besides the analyses of Lee propagation model usability, the possible optimization of the model is discussed as well. The research results can be used for accurate design, planning and for preparation of high-performance wireless resource management of various Internet of Things and Smart City applications in urban areas based on LoRa or similar wireless technology. The equipment used for measurements is based on open-source hardware.

  9. Do governing body and CSU nurses on clinical commissioning groups really lead a nursing agenda? Findings from a 2015 Survey of the Commissioning Nurse Leaders' Network Membership.

    Science.gov (United States)

    O'Driscoll, Mike; Allan, Helen T; Lee, Gay; Savage, Jan; Tapson, Christine; Dixon, Roz

    2018-03-05

    This paper reports the findings from a 2015 survey of the Commissioning Nurse Leaders' Network. Our aim was to understand how governing body nurses perceive their influence and leadership on clinical commissioning groups. An online survey method was used with a census sample of 238 governing body nurses and nurses working in Commissioning Support Units, who were members of the Commissioning Nurse Leaders' Network. The response rate was 40.7% (n = 97). While most governing body nurses felt confident in their leadership role, this was less so for non-executive governing body nurses. Nurses in Commissioning Support Units were much less positive than governing body nurses about their influence on clinical commissioning groups. Governing body nurses were satisfied with their impact on clinical commissioning groups and so could be said to be leading a nursing agenda but this evidence is limited to their own perceptions and more objective or diverse measures of impact are needed. The purpose of such roles to 'represent nursing, and ensure the patient voice is heard' may be a flawed aspiration, conflating nursing leadership and patient voice. This is the first study to explore explicitly the differences between executive and non-executive governing body nurses and nurses working in commissioning support units. Achieving clinical commissioning groups' goals, including developing and embedding nursing leadership roles in clinical commissioning groups, may be threatened if the contributions of governing body nurses, and other nurses supporting clinical commissioning groups, go unrecognised within the profession, or if general practitioners or other clinical commissioning group executive members dominate decision-making on clinical commissioning groups. © 2018 John Wiley & Sons Ltd.

  10. Functional and gene network analyses of transcriptional signatures characterizing pre-weaned bovine mammary parenchyma or fat pad uncovered novel inter-tissue signaling networks during development

    Directory of Open Access Journals (Sweden)

    Lewin Harris A

    2010-05-01

    Full Text Available Abstract Background The neonatal bovine mammary fat pad (MFP surrounding the mammary parenchyma (PAR is thought to exert proliferative effects on the PAR through secretion of local modulators of growth induced by systemic hormones. We used bioinformatics to characterize transcriptomics differences between PAR and MFP from ~65 d old Holstein heifers. Data were mined to uncover potential crosstalk through the analyses of signaling molecules preferentially expressed in one tissue relative to the other. Results Over 9,000 differentially expressed genes (DEG; False discovery rate ≤ 0.05 were found of which 1,478 had a ≥1.5-fold difference between PAR and MFP. Within the DEG highly-expressed in PAR vs. MFP (n = 736 we noted significant enrichment of functions related to cell cycle, structural organization, signaling, and DNA/RNA metabolism. Only actin cytoskeletal signaling was significant among canonical pathways. DEG more highly-expressed in MFP vs. PAR (n = 742 belong to lipid metabolism, signaling, cell movement, and immune-related functions. Canonical pathways associated with metabolism and signaling, particularly immune- and metabolism-related were significantly-enriched. Network analysis uncovered a central role of MYC, TP53, and CTNNB1 in controlling expression of DEG highly-expressed in PAR vs. MFP. Similar analysis suggested a central role for PPARG, KLF2, EGR2, and EPAS1 in regulating expression of more highly-expressed DEG in MFP vs. PAR. Gene network analyses revealed putative inter-tissue crosstalk between cytokines and growth factors preferentially expressed in one tissue (e.g., ANGPTL1, SPP1, IL1B in PAR vs. MFP; ADIPOQ, IL13, FGF2, LEP in MFP vs. PAR with DEG preferentially expressed in the other tissue, particularly transcription factors or pathways (e.g., MYC, TP53, and actin cytoskeletal signaling in PAR vs. MFP; PPARG and LXR/RXR Signaling in MFP vs. PAR. Conclusions Functional analyses underscored a reciprocal influence in

  11. Network, cluster and risk factor analyses for porcine reproductive and respiratory syndrome using data from swine sites participating in a disease control program.

    Science.gov (United States)

    Arruda, A G; Friendship, R; Carpenter, J; Hand, K; Poljak, Z

    2016-06-01

    The objectives of this study were to describe networks of Ontario swine sites and their service providers (including trucking, feed, semen, gilt and boar companies); to categorize swine sites into clusters based on site-level centrality measures, and to investigate risk factors for porcine reproductive and respiratory syndrome (PRRS) using information gathered from the above-mentioned analyses. All 816 sites included in the current study were enrolled in the PRRS area regional control and elimination projects in Ontario. Demographics, biosecurity and network data were collected using a standardized questionnaire and PRRS status was determined on the basis of available diagnostic tests and assessment by site veterinarians. Two-mode networks were transformed into one-mode dichotomized networks. Cluster and risk factor analyses were conducted separately for breeding and growing pig sites. In addition to the clusters obtained from cluster analyses, other explanatory variables of interest included: production type, type of animal flow, use of a shower facility, and number of neighboring swine sites within 3km. Unadjusted univariable analyses were followed by two types of adjusted models (adjusted for production systems): a generalizing estimation equation model (GEE) and a generalized linear mixed model (GLMM). Results showed that the gilt network was the most fragmented network, followed by the boar and truck networks. Considering all networks simultaneously, approximately 94% of all swine sites were indirectly connected. Unadjusted risk factor analyses showed significant associations between almost all predictors of interest and PRRS positivity, but these disappeared once production system was taken into consideration. Finally, the vast majority of the variation on PRRS status was explained by production system according to GLMM, which shows the highly correlated nature of the data, and raises the point that interventions at this level could potentially have high

  12. Automated water analyser computer supported system (AWACSS) Part I: Project objectives, basic technology, immunoassay development, software design and networking.

    Science.gov (United States)

    Tschmelak, Jens; Proll, Guenther; Riedt, Johannes; Kaiser, Joachim; Kraemmer, Peter; Bárzaga, Luis; Wilkinson, James S; Hua, Ping; Hole, J Patrick; Nudd, Richard; Jackson, Michael; Abuknesha, Ram; Barceló, Damià; Rodriguez-Mozaz, Sara; de Alda, Maria J López; Sacher, Frank; Stien, Jan; Slobodník, Jaroslav; Oswald, Peter; Kozmenko, Helena; Korenková, Eva; Tóthová, Lívia; Krascsenits, Zoltan; Gauglitz, Guenter

    2005-02-15

    A novel analytical system AWACSS (automated water analyser computer-supported system) based on immunochemical technology has been developed that can measure several organic pollutants at low nanogram per litre level in a single few-minutes analysis without any prior sample pre-concentration nor pre-treatment steps. Having in mind actual needs of water-sector managers related to the implementation of the Drinking Water Directive (DWD) (98/83/EC, 1998) and Water Framework Directive WFD (2000/60/EC, 2000), drinking, ground, surface, and waste waters were major media used for the evaluation of the system performance. The instrument was equipped with remote control and surveillance facilities. The system's software allows for the internet-based networking between the measurement and control stations, global management, trend analysis, and early-warning applications. The experience of water laboratories has been utilised at the design of the instrument's hardware and software in order to make the system rugged and user-friendly. Several market surveys were conducted during the project to assess the applicability of the final system. A web-based AWACSS database was created for automated evaluation and storage of the obtained data in a format compatible with major databases of environmental organic pollutants in Europe. This first part article gives the reader an overview of the aims and scope of the AWACSS project as well as details about basic technology, immunoassays, software, and networking developed and utilised within the research project. The second part article reports on the system performance, first real sample measurements, and an international collaborative trial (inter-laboratory tests) to compare the biosensor with conventional anayltical methods.

  13. Author-paper affiliation network architecture influences the methodological quality of systematic reviews and meta-analyses of psoriasis.

    Directory of Open Access Journals (Sweden)

    Juan Luis Sanz-Cabanillas

    Full Text Available Moderate-to-severe psoriasis is associated with significant comorbidity, an impaired quality of life, and increased medical costs, including those associated with treatments. Systematic reviews (SRs and meta-analyses (MAs of randomized clinical trials are considered two of the best approaches to the summarization of high-quality evidence. However, methodological bias can reduce the validity of conclusions from these types of studies and subsequently impair the quality of decision making. As co-authorship is among the most well-documented forms of research collaboration, the present study aimed to explore whether authors' collaboration methods might influence the methodological quality of SRs and MAs of psoriasis. Methodological quality was assessed by two raters who extracted information from full articles. After calculating total and per-item Assessment of Multiple Systematic Reviews (AMSTAR scores, reviews were classified as low (0-4, medium (5-8, or high (9-11 quality. Article metadata and journal-related bibliometric indices were also obtained. A total of 741 authors from 520 different institutions and 32 countries published 220 reviews that were classified as high (17.2%, moderate (55%, or low (27.7% methodological quality. The high methodological quality subnetwork was larger but had a lower connection density than the low and moderate methodological quality subnetworks; specifically, the former contained relatively fewer nodes (authors and reviews, reviews by authors, and collaborators per author. Furthermore, the high methodological quality subnetwork was highly compartmentalized, with several modules representing few poorly interconnected communities. In conclusion, structural differences in author-paper affiliation network may influence the methodological quality of SRs and MAs on psoriasis. As the author-paper affiliation network structure affects study quality in this research field, authors who maintain an appropriate balance

  14. Acupuncture-Related Techniques for Psoriasis: A Systematic Review with Pairwise and Network Meta-Analyses of Randomized Controlled Trials.

    Science.gov (United States)

    Yeh, Mei-Ling; Ko, Shu-Hua; Wang, Mei-Hua; Chi, Ching-Chi; Chung, Yu-Chu

    2017-12-01

    There has be a large body of evidence on the pharmacological treatments for psoriasis, but whether nonpharmacological interventions are effective in managing psoriasis remains largely unclear. This systematic review conducted pairwise and network meta-analyses to determine the effects of acupuncture-related techniques on acupoint stimulation for the treatment of psoriasis and to determine the order of effectiveness of these remedies. This study searched the following databases from inception to March 15, 2016: Medline, PubMed, Cochrane Central Register of Controlled Trials, EBSCO (including Academic Search Premier, American Doctoral Dissertations, and CINAHL), Airiti Library, and China National Knowledge Infrastructure. Randomized controlled trials (RCTs) on the effects of acupuncture-related techniques on acupoint stimulation as intervention for psoriasis were independently reviewed by two researchers. A total of 13 RCTs with 1,060 participants were included. The methodological quality of included studies was not rigorous. Acupoint stimulation, compared with nonacupoint stimulation, had a significant treatment for psoriasis. However, the most common adverse events were thirst and dry mouth. Subgroup analysis was further done to confirm that the short-term treatment effect was superior to that of the long-term effect in treating psoriasis. Network meta-analysis identified acupressure or acupoint catgut embedding, compared with medication, and had a significant effect for improving psoriasis. It was noted that acupressure was the most effective treatment. Acupuncture-related techniques could be considered as an alternative or adjuvant therapy for psoriasis in short term, especially of acupressure and acupoint catgut embedding. This study recommends further well-designed, methodologically rigorous, and more head-to-head randomized trials to explore the effects of acupuncture-related techniques for treating psoriasis.

  15. State dependent properties of epileptic brain networks: comparative graph-theoretical analyses of simultaneously recorded EEG and MEG.

    Science.gov (United States)

    Horstmann, Marie-Therese; Bialonski, Stephan; Noennig, Nina; Mai, Heinke; Prusseit, Jens; Wellmer, Jörg; Hinrichs, Hermann; Lehnertz, Klaus

    2010-02-01

    To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval. We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics. Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings. Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks. An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks. Copyright (c) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  16. Complementarity, relation-specific investment, and opportunism : explaining asymmetric governance modes in hub-and-spoke networks within the enterprise application software industry

    OpenAIRE

    Kude, Thomas; Dibbern, Jens; Heinzl, Armin

    2008-01-01

    In the enterprise application software industry, dominant system vendors (hubs) have formed strategic partnerships with small software companies (spokes), resulting in the emergence of hub-and-spoke networks. Based upon the concept of software stacks, we argue that the governance mechanisms applied by hub and spokes depend on the complementarity between hub’s and spoke’s resources. Specifically, we draw on the relational view and combine it with the resource dependence theory to develop a the...

  17. Communication, advice exchange and job satisfaction of nursing staff: a social network analyses of 35 long-term care units.

    NARCIS (Netherlands)

    Beek, A.P.A. van; Wagner, C.; Spreeuwenberg, P.P.M.; Frijters, D.H.M.; Ribbe, M.W.; Groenewegen, P.P.

    2011-01-01

    Background: The behaviour of individuals is affected by the social networks in which they are embedded. Networks are also important for the diffusion of information and the influence of employees in organisations. Yet, at the moment little is known about the social networks of nursing staff in

  18. Urban environmental services and the state in East Africa; between neo-developmental and network governance approaches

    NARCIS (Netherlands)

    Oosterveer, P.J.M.

    2009-01-01

    Although governments are generally expected to provide environmental services such as sanitation and solid waste collection for their citizens, most (municipal) governments in Sub-Saharan Africa seem hardly able to take up this task. Without ignoring the lack of material resources resulting from

  19. LNS users primer for accessing government sites on the ARPA network. [MIT. -->. ANL, BNL, LBL, and New York Univ. Courant Inst

    Energy Technology Data Exchange (ETDEWEB)

    Kannel, M.

    1979-06-01

    This primer was developed as part of the study conducted by the Laboratory for Nuclear Science (LNS) on the feasibility of networks for computer resource sharing. The primer is an instructinal guide for the LNS user who would like to access and use computers at other government sites on the ARPA network. The format is a series of scenarios of actual recorded on-line terminal sessions' showing the novice user how to access the foreign site, obtain help documentation, run a simple program, and transfer files to and from the foreign site. Access to the ARPA network in these scenarios is via Multics or the Massachusetts Institute of Technology Terminal Interface Processor. The foreign government sites accessed are the computing facilities at Argonne National Laboratory, Brookhaven National Laboratory, Lawrence Livermore Laboratory, and New York University Courant Institute. This technique of auditing actual terminal sessions as a teaching aid can be extended to include other computing facilities as well as other networks.

  20. Forms of global governence

    Directory of Open Access Journals (Sweden)

    Maxim V. Kharkevich

    2014-01-01

    Full Text Available Global governance as a concept defines the meaning of contemporary world politics both as a discipline and as reality. Interdependent and globalized world requires governance, and a global government has not been formed yet. The theoretical possibility of global governance without global government is proved and justified. The purpose of this article is to analytically identify possible forms of global governance. Three such forms of global governance are identified: hierarchical, market and network. In a hierarchy the governance is due to the asymmetry of power between the parties. Market control happens via anonymous pricing mechanism. Network, in contrast to the market is characterized by a closer value link between the actors, but unlike the hierarchical relationship actors are free to leave the network. Global governance takes three forms and is being implemented by different actors. To determine the most efficient form of global governance is impossible. Efficiency depends on the match between a form and an object of government. It should be noted that meta governance is likely to remain a monopoly of institutionally strong states in global governance.

  1. Integration in primary community care networks (PCCNs): examination of governance, clinical, marketing, financial, and information infrastructures in a national demonstration project in Taiwan.

    Science.gov (United States)

    Lin, Blossom Yen-Ju

    2007-06-19

    Taiwan's primary community care network (PCCN) demonstration project, funded by the Bureau of National Health Insurance on March 2003, was established to discourage hospital shopping behavior of people and drive the traditional fragmented health care providers into cooperate care models. Between 2003 and 2005, 268 PCCNs were established. This study profiled the individual members in the PCCNs to study the nature and extent to which their network infrastructures have been integrated among the members (clinics and hospitals) within individual PCCNs. The thorough questionnaire items, covering the network working infrastructures--governance, clinical, marketing, financial, and information integration in PCCNs, were developed with validity and reliability confirmed. One thousand five hundred and fifty-seven clinics that had belonged to PCCNs for more than one year, based on the 2003-2005 Taiwan Primary Community Care Network List, were surveyed by mail. Nine hundred and twenty-eight clinic members responded to the surveys giving a 59.6 % response rate. Overall, the PCCNs' members had higher involvement in the governance infrastructure, which was usually viewed as the most important for establishment of core values in PCCNs' organization design and management at the early integration stage. In addition, it found that there existed a higher extent of integration of clinical, marketing, and information infrastructures among the hospital-clinic member relationship than those among clinic members within individual PCCNs. The financial infrastructure was shown the least integrated relative to other functional infrastructures at the early stage of PCCN formation. There was still room for better integrated partnerships, as evidenced by the great variety of relationships and differences in extent of integration in this study. In addition to provide how the network members have done for their initial work at the early stage of network forming in this study, the detailed surveyed

  2. Walking- and cycling track networks in Norwegian cities : cost-benefit analyses including health effects and external costs of road traffic : summary

    Science.gov (United States)

    2002-04-01

    Cost- benefit analyses of walking- and cycling track net-works in three Norwegian cities are presented in this study. A project group working with a National Cycling Strategy in Norway initialised the study. Motivation for starting the study is the P...

  3. A CFBPN Artificial Neural Network Model for Educational Qualitative Data Analyses: Example of Students' Attitudes Based on Kellerts' Typologies

    Science.gov (United States)

    Yorek, Nurettin; Ugulu, Ilker

    2015-01-01

    In this study, artificial neural networks are suggested as a model that can be "trained" to yield qualitative results out of a huge amount of categorical data. It can be said that this is a new approach applied in educational qualitative data analysis. In this direction, a cascade-forward back-propagation neural network (CFBPN) model was…

  4. Regulation, Governance and Adaptation. Governance transformations in the Dutch and French liberalizing electricity industries

    Energy Technology Data Exchange (ETDEWEB)

    Niesten, E.M.M.I.

    2009-06-11

    For more than a decade, the European governments have focused their energy policies on creating one European competitive electricity market. Several regulations are introduced into the European electricity industries for this purpose: the energy firms have to unbundle the electricity networks from electricity generation and retail, and the consumers should be able to choose their electricity retailer. This thesis analyses which new governance structures emerged in the Dutch and French electricity industries as a result of these regulations for four types of electricity transactions: the network connection, network access, balancing and switching transactions. The parties in these electricity industries did not adopt a market, but hybrid forms of governance that remained extensively regulated. The efficiency of these new governance structures cannot be explained with the attributes of the transactions, as is proposed by transaction cost economics. This thesis therefore introduces the concept of adaptation into transaction cost economics. Adaptation is the adjustment by economic actors from one governance structure to another, and is characterized by three attributes: the identity of the future contracting party, the laterality of the adaption, and the type of response in the adaptation process. These attributes explain the governance transformations and the new governance structures in the two industries. Regulation continues to play a pervasive role in the liberalized electricity industries. It influences the attributes of the transactions, the new governance structures and the adaptation process.

  5. Integrated in silico Analyses of Regulatory and Metabolic Networks of Synechococcus sp. PCC 7002 Reveal Relationships between Gene Centrality and Essentiality

    Science.gov (United States)

    Song, Hyun-Seob; McClure, Ryan S.; Bernstein, Hans C.; Overall, Christopher C.; Hill, Eric A.; Beliaev, Alexander S.

    2015-01-01

    Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon processing rates. The output of such adaptations is reflected through changes in transcriptional patterns and metabolic flux distributions that ultimately define growth strategy. To address interrelationships between metabolism and regulation, we performed integrative analyses of metabolic and gene co-expression networks in a model cyanobacterium, Synechococcus sp. PCC 7002. Centrality analyses using the gene co-expression network identified a set of key genes, which were defined here as “topologically important.” Parallel in silico gene knock-out simulations, using the genome-scale metabolic network, classified what we termed as “functionally important” genes, deletion of which affected growth or metabolism. A strong positive correlation was observed between topologically and functionally important genes. Functionally important genes exhibited variable levels of topological centrality; however, the majority of topologically central genes were found to be functionally essential for growth. Subsequent functional enrichment analysis revealed that both functionally and topologically important genes in Synechococcus sp. PCC 7002 are predominantly associated with translation and energy metabolism, two cellular processes critical for growth. This research demonstrates how synergistic network-level analyses can be used for reconciliation of metabolic and gene expression data to uncover fundamental biological principles. PMID:25826650

  6. Integrated in silico Analyses of Regulatory and Metabolic Networks of Synechococcus sp. PCC 7002 Reveal Relationships between Gene Centrality and Essentiality

    Directory of Open Access Journals (Sweden)

    Hyun-Seob Song

    2015-03-01

    Full Text Available Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon processing rates. The output of such adaptations is reflected through changes in transcriptional patterns and metabolic flux distributions that ultimately define growth strategy. To address interrelationships between metabolism and regulation, we performed integrative analyses of metabolic and gene co-expression networks in a model cyanobacterium, Synechococcus sp. PCC 7002. Centrality analyses using the gene co-expression network identified a set of key genes, which were defined here as “topologically important.” Parallel in silico gene knock-out simulations, using the genome-scale metabolic network, classified what we termed as “functionally important” genes, deletion of which affected growth or metabolism. A strong positive correlation was observed between topologically and functionally important genes. Functionally important genes exhibited variable levels of topological centrality; however, the majority of topologically central genes were found to be functionally essential for growth. Subsequent functional enrichment analysis revealed that both functionally and topologically important genes in Synechococcus sp. PCC 7002 are predominantly associated with translation and energy metabolism, two cellular processes critical for growth. This research demonstrates how synergistic network-level analyses can be used for reconciliation of metabolic and gene expression data to uncover fundamental biological principles.

  7. Structural Conditions for Collaboration and Learning in Innovation Networks: Using an Innovation System Performance Lens to Analyse Agricultural Knowledge Systems

    NARCIS (Netherlands)

    Hermans, F.; Klerkx, L.W.A.; Roep, D.

    2015-01-01

    Purpose: We investigate how the structural conditions of eight different European agricultural innovation systems can facilitate or hinder collaboration and social learning in multidisciplinary innovation networks. Methodology: We have adapted the Innovation System Failure Matrix to investigate the

  8. Summary of the First Network-Centric Sensing Community Workshop, ’Netted Sensors: A Government, Industry and Academia Dialogue’

    Science.gov (United States)

    2006-04-01

    domain of the academic community. Companies, such as Dust Networks (www.dustnetworks.com), Crossbow Technologies (www.xbow.com), and Millennial Net...Wireless Sensor Networks – Issues and Applications Dr. Sokwoo Rhee ( Millennial Net) presented a talk on the impact of efficient routing schemes on...engaging talk spanning the realm from Internet-0 techniques for waveform coding using broadband impulse response functions to statistical mechanics

  9. You are what your friends eat: systematic review of social network analyses of young peoplea ?s eating behaviours and bodyweight.

    OpenAIRE

    2011-01-01

    Abstract Background: This review synthesises evidence regarding associations between young peoplei??s social networks and their eating behaviours/bodyweight and also explores how these vary according to the setting and sample characteristics. Methods: Systematic review of cross-sectional and longitudinal observational studies examining the association between measures of young peoplei??s social networks based on socio-metric data and eating behaviours (including calorific intak...

  10. EDENetworks: A user-friendly software to build and analyse networks in biogeography, ecology and population genetics

    OpenAIRE

    Kivela, Mikko; Arnaud-haond, Sophie; Saramaki, Jari

    2015-01-01

    The recent application of graph-based network theory analysis to biogeography, community ecology and population genetics has created a need for user-friendly software, which would allow a wider accessibility to and adaptation of these methods. EDENetworks aims to fill this void by providing an easy-to-use interface for the whole analysis pipeline of ecological and evolutionary networks starting from matrices of species distributions, genotypes, bacterial OTUs or populations characterized gene...

  11. Organization of brain networks governed by long-range connections index autistic traits in the general population.

    Science.gov (United States)

    Barttfeld, Pablo; Amoruso, Lucía; Ais, Joaquín; Cukier, Sebastián; Bavassi, Luz; Tomio, Ailin; Manes, Facundo; Ibanez, Agustín; Sigman, Mariano

    2013-06-27

    The dimensional approach to autism spectrum disorder (ASD) considers ASD as the extreme of a dimension traversing through the entire population. We explored the potential utility of electroencephalography (EEG) functional connectivity as a biomarker. We hypothesized that individual differences in autistic traits of typical subjects would involve a long-range connectivity diminution within the delta band. Resting-state EEG functional connectivity was measured for 74 neurotypical subjects. All participants also provided a questionnaire (Social Responsiveness Scale, SRS) that was completed by an informant who knows the participant in social settings. We conducted multivariate regression between the SRS score and functional connectivity in all EEG frequency bands. We explored modulations of network graph metrics characterizing the optimality of a network using the SRS score. Our results show a decay in functional connectivity mainly within the delta and theta bands (the lower part of the EEG spectrum) associated with an increasing number of autistic traits. When inspecting the impact of autistic traits on the global organization of the functional network, we found that the optimal properties of the network are inversely related to the number of autistic traits, suggesting that the autistic dimension, throughout the entire population, modulates the efficiency of functional brain networks. EEG functional connectivity at low frequencies and its associated network properties may be associated with some autistic traits in the general population.

  12. Governance and Risk Management of Network and Information Security: The Role of Public Private Partnerships in Managing the Existing and Emerging Risks

    Science.gov (United States)

    Navare, Jyoti; Gemikonakli, Orhan

    Globalisation and new technology has opened the gates to more security risks. As the strategic importance of communication networks and information increased, threats to the security and safety of communication infrastructures, as well as information stored in and/or transmitted increased significantly. The development of the self replicating programmes has become a nightmare for Internet users. Leading companies, strategic organisations were not immune to attacks; they were also "hacked" and overtaken by intruders. Incidents of recent years have also shown that national/regional crisis may also trigger cyber attacks at large scale. Experts forecast that cyber wars are likely to take the stage as tension mounts between developed societies. New risks such as cyber-attacks, network terrorism and disintegration of traditional infrastructures has somewhat blurred the boundaries of operation and control. This paper seeks to consider the risk management and governance and looking more specifically at implications for emerging economies.

  13. Networked governance and the management of ecosystem services: The case of urban environmental stewardship in New York City

    Science.gov (United States)

    James J.T. Connolly; Erika S. Svendsen; Dana R. Fisher; Lindsay K. Campbell

    2014-01-01

    Urban environmental stewardship groups have become an essential component of the governance structure that regulates ecosystem services in cities. New York City is one example where these groups have grown rapidly in number, size, and visibility since the 1970s. In this article, we combine quantitative survey data with qualitative interview data to examine the...

  14. Toward an understanding of citywide urban environmental governance: An examination of stewardship networks in Baltimore and Seattle

    Science.gov (United States)

    Michele Romolini; Morgan Grove; Curtis L. Ventriss; Christopher J. Koliba; Daniel H. Krymkowski

    2016-01-01

    Efforts to create more sustainable cities are evident in the proliferation of sustainability policies in cities worldwide. It has become widely proposed that the success of these urban sustainability initiatives will require city agencies to partner with, and even cede authority to, organizations from other sectors and levels of government. Yet the resulting...

  15. On the need for increased rigour and care in the conduct and interpretation of network meta-analyses in drug development.

    Science.gov (United States)

    Carroll, Kevin; Hemmings, Robert

    2016-01-01

    The rise over recent years in the use of network meta-analyses (NMAs) in clinical research and health economic analysis is little short of meteoric driven, in part, by a desire from decision makers to extend inferences beyond direct comparisons in controlled clinical trials. But is the increased use and reliance of NMAs justified? Do such analyses provide a reliable basis for the relative effectiveness assessment of medicines and, in turn, for critical decisions relating to healthcare access and provisioning? And can such analyses also be used earlier, as part of the evidence base for licensure? Despite several important publications highlighting inherently unverifiable assumptions underpinning NMAs, these assumptions and associated potential for serious bias are often overlooked in the reporting and interpretation of NMAs. A more cautious, and better informed, approach to the use and interpretation of NMAs in clinical research is warranted given the assumptions that sit behind such analyses. Copyright © 2015 John Wiley & Sons, Ltd.

  16. Rainfall model investigation and scenario analyses of the effect of government reforestation policy on seasonal rainfalls: A case study from Northern Thailand

    Science.gov (United States)

    Duangdai, Eakkapong; Likasiri, Chulin

    2017-03-01

    In this work, 4 models for predicting rainfall amounts are investigated and compared using Northern Thailand's seasonal rainfall data for 1973-2008. Two models, global temperature, forest area and seasonal rainfall (TFR) and modified TFR based on a system of differential equations, give the relationships between global temperature, Northern Thailand's forest cover and seasonal rainfalls in the region. The other two models studied are time series and Autoregressive Moving Average (ARMA) models. All models are validated using the k-fold cross validation method with the resulting errors being 0.971233, 0.740891, 2.376415 and 2.430891 for time series, ARMA, TFR and modified TFR models, respectively. Under Business as Usual (BaU) scenario, seasonal rainfalls in Northern Thailand are projected through the year 2020 using all 4 models. TFR and modified TFR models are also used to further analyze how global temperature rise and government reforestation policy affect seasonal rainfalls in the region. Rainfall projections obtained via the two models are also compared with those from the International Panel on Climate Change (IPCC) under IS92a scenario. Results obtained through a mathematical model for global temperature, forest area and seasonal rainfall show that the higher the forest cover, the less fluctuation there is between rainy-season and summer rainfalls. Moreover, growth in forest cover also correlates with an increase in summer rainfalls. An investigation into the relationship between main crop productions and rainfalls in dry and rainy seasons indicates that if the rainy-season rainfall is high, that year's main-crop rice production will decrease but the second-crop rice, maize, sugarcane and soybean productions will increase in the following year.

  17. Leisure, Government and Governance: A Swedish Perspective

    Science.gov (United States)

    Lindstrom, Lisbeth

    2011-01-01

    The leisure sector has witnessed a tremendous expansion since 1960. The purpose of this article is to analyse the decisions and goals of Swedish government policy during the period 1962 to 2005. The empirical analysis covers government Propositions and governmental investigations. The fields covered are sports, culture, exercise, tourism and…

  18. Advancing the application of systems thinking in health: analysing the contextual and social network factors influencing the use of sustainability indicators in a health system--a comparative study in Nepal and Somaliland.

    Science.gov (United States)

    Blanchet, Karl; Palmer, Jennifer; Palanchowke, Raju; Boggs, Dorothy; Jama, Ali; Girois, Susan

    2014-08-26

    Health systems strengthening is becoming a key component of development agendas for low-income countries worldwide. Systems thinking emphasizes the role of diverse stakeholders in designing solutions to system problems, including sustainability. The objective of this paper is to compare the definition and use of sustainability indicators developed through the Sustainability Analysis Process in two rehabilitation sectors, one in Nepal and one in Somaliland, and analyse the contextual factors (including the characteristics of system stakeholder networks) influencing the use of sustainability data. Using the Sustainability Analysis Process, participants collectively clarified the boundaries of their respective systems, defined sustainability, and identified sustainability indicators. Baseline indicator data was gathered, where possible, and then researched again 2 years later. As part of the exercise, system stakeholder networks were mapped at baseline and at the 2-year follow-up. We compared stakeholder networks and interrelationships with baseline and 2-year progress toward self-defined sustainability goals. Using in-depth interviews and observations, additional contextual factors affecting the use of sustainability data were identified. Differences in the selection of sustainability indicators selected by local stakeholders from Nepal and Somaliland reflected differences in the governance and structure of the present rehabilitation system. At 2 years, differences in the structure of social networks were more marked. In Nepal, the system stakeholder network had become more dense and decentralized. Financial support by an international organization facilitated advancement toward self-identified sustainability goals. In Somaliland, the small, centralised stakeholder network suffered a critical rupture between the system's two main information brokers due to competing priorities and withdrawal of international support to one of these. Progress toward self

  19. Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington's Disease.

    Science.gov (United States)

    Scarpa, Joseph R; Jiang, Peng; Losic, Bojan; Readhead, Ben; Gao, Vance D; Dudley, Joel T; Vitaterna, Martha H; Turek, Fred W; Kasarskis, Andrew

    2016-07-01

    Recent systems-based analyses have demonstrated that sleep and stress traits emerge from shared genetic and transcriptional networks, and clinical work has elucidated the emergence of sleep dysfunction and stress susceptibility as early symptoms of Huntington's disease. Understanding the biological bases of these early non-motor symptoms may reveal therapeutic targets that prevent disease onset or slow disease progression, but the molecular mechanisms underlying this complex clinical presentation remain largely unknown. In the present work, we specifically examine the relationship between these psychiatric traits and Huntington's disease (HD) by identifying striatal transcriptional networks shared by HD, stress, and sleep phenotypes. First, we utilize a systems-based approach to examine a large publicly available human transcriptomic dataset for HD (GSE3790 from GEO) in a novel way. We use weighted gene coexpression network analysis and differential connectivity analyses to identify transcriptional networks dysregulated in HD, and we use an unbiased ranking scheme that leverages both gene- and network-level information to identify a novel astrocyte-specific network as most relevant to HD caudate. We validate this result in an independent HD cohort. Next, we computationally predict FOXO3 as a regulator of this network, and use multiple publicly available in vitro and in vivo experimental datasets to validate that this astrocyte HD network is downstream of a signaling pathway important in adult neurogenesis (TGFβ-FOXO3). We also map this HD-relevant caudate subnetwork to striatal transcriptional networks in a large (n = 100) chronically stressed (B6xA/J)F2 mouse population that has been extensively phenotyped (328 stress- and sleep-related measurements), and we show that this striatal astrocyte network is correlated to sleep and stress traits, many of which are known to be altered in HD cohorts. We identify causal regulators of this network through Bayesian network

  20. Analyses of systems and their behaviour in extraordinary situations as based on the latest results in network sciences and extensive empirical investigations; Netzwerkanalyse fuer ein antizipatives Katastrophenmanagement

    Energy Technology Data Exchange (ETDEWEB)

    Ammoser, H. [Technische Univ. Dresden (Germany). Inst. fuer Wirtschaft und Verkehr; Kuehnert, C. [Technische Univ. Dresden (Germany). Inst. fuer Wirtschaft und Verkehr; Imperial College, London (United Kingdom); Buzna, L. [Zilina Univ. (Slovakia). Dept. of Transportation Networks

    2006-07-01

    In the context of a DFG research project, scientists of Prof. Helbing's chair at the Institute of Transport and Economics deal with the dynamics of disasters, being experienced in the modelling of complex systems and in the simulation of emergency scenarios. The analyses of systems and their behaviour in extraordinary events are based on the latest results of network sciences and on numerous empirical investigations. The results shall be used for precaution measures and innovations in disaster recovery. (orig.)

  1. Integration in primary community care networks (PCCNs: examination of governance, clinical, marketing, financial, and information infrastructures in a national demonstration project in Taiwan

    Directory of Open Access Journals (Sweden)

    Lin Blossom Yen-Ju

    2007-06-01

    Full Text Available Abstract Background Taiwan's primary community care network (PCCN demonstration project, funded by the Bureau of National Health Insurance on March 2003, was established to discourage hospital shopping behavior of people and drive the traditional fragmented health care providers into cooperate care models. Between 2003 and 2005, 268 PCCNs were established. This study profiled the individual members in the PCCNs to study the nature and extent to which their network infrastructures have been integrated among the members (clinics and hospitals within individual PCCNs. Methods The thorough questionnaire items, covering the network working infrastructures – governance, clinical, marketing, financial, and information integration in PCCNs, were developed with validity and reliability confirmed. One thousand five hundred and fifty-seven clinics that had belonged to PCCNs for more than one year, based on the 2003–2005 Taiwan Primary Community Care Network List, were surveyed by mail. Nine hundred and twenty-eight clinic members responded to the surveys giving a 59.6 % response rate. Results Overall, the PCCNs' members had higher involvement in the governance infrastructure, which was usually viewed as the most important for establishment of core values in PCCNs' organization design and management at the early integration stage. In addition, it found that there existed a higher extent of integration of clinical, marketing, and information infrastructures among the hospital-clinic member relationship than those among clinic members within individual PCCNs. The financial infrastructure was shown the least integrated relative to other functional infrastructures at the early stage of PCCN formation. Conclusion There was still room for better integrated partnerships, as evidenced by the great variety of relationships and differences in extent of integration in this study. In addition to provide how the network members have done for their initial work at

  2. To Infinity and Beyond ...: Heterarchical Governance, the Teach for All Network in Europe and the Making of Profits and Minds

    Science.gov (United States)

    Olmedo, Antonio; Bailey, Patrick L. J.; Ball, Stephen J.

    2013-01-01

    This article explores the increasing commercialisation of education through the empirical case of Teach For All, a network of social enterprises which is spreading a new model of teacher training across Europe and around the world. This model, which is supported and funded by a heterogeneous mix of public institutions and private sector…

  3. Shifting Tides in Global Higher Education: Agency, Autonomy, and Governance in the Global Network. Global Studies in Education, Volume 9

    Science.gov (United States)

    Witt, Mary Allison

    2011-01-01

    The increasing connection among higher education institutions worldwide is well documented. What is less understood is how this connectivity is enacted and manifested on specific levels of the global education network. This book details the planning process of a multi-institutional program in engineering between institutions in the US and…

  4. Structural Conditions for Collaboration and Learning in Innovation Networks: Using an Innovation System Performance Lens to Analyse Agricultural Knowledge Systems

    Science.gov (United States)

    Hermans, Frans; Klerkx, Laurens; Roep, Dirk

    2015-01-01

    Purpose: We investigate how the structural conditions of eight different European agricultural innovation systems can facilitate or hinder collaboration and social learning in multidisciplinary innovation networks. Methodology: We have adapted the Innovation System Failure Matrix to investigate the main barriers and enablers eight countries…

  5. Greenhouse gas network design using backward Lagrangian particle dispersion modelling – Part 2: Sensitivity analyses and South African test case

    CSIR Research Space (South Africa)

    Nickless, A

    2014-05-01

    Full Text Available This is the second part of a two-part paper considering network design based on a Lagrangian stochastic particle dispersion model (LPDM), aimed at reducing the uncertainty of the flux estimates achievable for the region of interest by the continuous...

  6. You are what your friends eat: systematic review of social network analyses of young people's eating behaviours and bodyweight.

    Science.gov (United States)

    Fletcher, Adam; Bonell, Chris; Sorhaindo, Annik

    2011-06-01

    This review synthesises evidence regarding associations between young people's social networks and their eating behaviours/bodyweight, and also explores how these vary according to the setting and sample characteristics. A systematic review of cross-sectional and longitudinal observational studies examining the association between measures of young people's social networks based on sociometric data and eating behaviours (including calorific intake) and/or bodyweight. There is consistent evidence that school friends are significantly similar in terms of their body mass index, and friends with the highest body mass index appear to be most similar. Overweight youth are also less likely to be popular and more likely to be socially isolated at school. Frequency of fast food consumption has also been found to cluster within groups of boys, as have body image concerns, dieting and eating disorders among girls. School friendships may be critical in shaping young people's eating behaviours and bodyweight and/or vice versa, and suggests the potential of social-network-based health promotion interventions in schools. Further longitudinal research is needed to examine the processes via which this clustering occurs, how it varies according to school context, and the effects of non-school networks.

  7. Development and Analyses of Privacy Management Models in Online Social Networks Based on Communication Privacy Management Theory

    Science.gov (United States)

    Lee, Ki Jung

    2013-01-01

    Online social networks (OSNs), while serving as an emerging means of communication, promote various issues of privacy. Users of OSNs encounter diverse occasions that lead to invasion of their privacy, e.g., published conversation, public revelation of their personally identifiable information, and open boundary of distinct social groups within…

  8. Implementing voice over Internet protocol in mobile ad hoc networkanalysing its features regarding efficiency, reliability and security

    Directory of Open Access Journals (Sweden)

    Naveed Ahmed Sheikh

    2014-05-01

    Full Text Available Providing secure and efficient real-time voice communication in mobile ad hoc network (MANET environment is a challenging problem. Voice over Internet protocol (VoIP has originally been developed over the past two decades for infrastructure-based networks. There are strict timing constraints for acceptable quality VoIP services, in addition to registration and discovery issues in VoIP end-points. In MANETs, ad hoc nature of networks and multi-hop wireless environment with significant packet loss and delays present formidable challenges to the implementation. Providing a secure real-time VoIP service on MANET is the main design objective of this paper. The authors have successfully developed a prototype system that establishes reliable and efficient VoIP communication and provides an extremely flexible method for voice communication in MANETs. The authors’ cooperative mesh-based MANET implementation can be used for rapidly deployable VoIP communication with survivable and efficient dynamic networking using open source software.

  9. Sao Paulo Lightning Mapping Array (SP-LMA): Network Assessment and Analyses for Intercomparison Studies and GOES-R Proxy Activities

    Science.gov (United States)

    Bailey, J. C.; Blakeslee, R. J.; Carey, L. D.; Goodman, S. J.; Rudlosky, S. D.; Albrecht, R.; Morales, C. A.; Anselmo, E. M.; Neves, J. R.; Buechler, D. E.

    2014-01-01

    A 12 station Lightning Mapping Array (LMA) network was deployed during October 2011 in the vicinity of Sao Paulo, Brazil (SP-LMA) to contribute total lightning measurements to an international field campaign [CHUVA - Cloud processes of tHe main precipitation systems in Brazil: A contribUtion to cloud resolVing modeling and to the GPM (GlobAl Precipitation Measurement)]. The SP-LMA was operational from November 2011 through March 2012 during the Vale do Paraiba campaign. Sensor spacing was on the order of 15-30 km, with a network diameter on the order of 40-50km. The SP-LMA provides good 3-D lightning mapping out to 150 km from the network center, with 2-D coverage considerably farther. In addition to supporting CHUVA science/mission objectives, the SP-LMA is supporting the generation of unique proxy data for the Geostationary Lightning Mapper (GLM) and Advanced Baseline Imager (ABI), on NOAA's Geostationary Operational Environmental Satellite-R (GOES-R: scheduled for a 2015 launch). These proxy data will be used to develop and validate operational algorithms so that they will be ready to use on "day1" following the GOES-R launch. As the CHUVA Vale do Paraiba campaign opportunity was formulated, a broad community-based interest developed for a comprehensive Lightning Location System (LLS) intercomparison and assessment study, leading to the participation and/or deployment of eight other ground-based networks and the space-based Lightning Imaging Sensor (LIS). The SP-LMA data is being intercompared with lightning observations from other deployed lightning networks to advance our understanding of the capabilities/contributions of each of these networks toward GLM proxy and validation activities. This paper addresses the network assessment including noise reduction criteria, detection efficiency estimates, and statistical and climatological (both temporal and spatially) analyses for intercomparison studies and GOES-R proxy activities.

  10. Descriptive and network analyses of the equine contact network at an equestrian show in Ontario, Canada and implications for disease spread.

    Science.gov (United States)

    Spence, Kelsey L; O'Sullivan, Terri L; Poljak, Zvonimir; Greer, Amy L

    2017-06-21

    Identifying the contact structure within a population of horses attending a competition is an important element towards understanding the potential for the spread of equine pathogens as the horses subsequently travel from location to location. However, there is limited information in Ontario, Canada to quantify contact patterns of horses. The objective of this study was to describe the network of potential contacts associated with an equestrian show to determine how this network structure may influence potential disease transmission. This was a descriptive study of horses attending an equestrian show in southern Ontario, Canada on July 6 and 7, 2014. Horse show participants completed a questionnaire about their horse, travel patterns, and infection control practices. Questionnaire responses were received from horse owners of 79.7% (55/69) of the horses attending the show. Owners reported that horses attending the show were vaccinated for diseases such as rabies, equine influenza, and equine herpesvirus. Owners demonstrated high compliance with most infection control practices by reporting reduced opportunities for direct and indirect contact while away from home. The two-mode undirected network consisted of 820 nodes (41 locations and 779 horses). Eight percent of nodes in the network represented horses attending the show, 87% of nodes represented horses not attending the show, but boarded at individual home facilities, and 5% represented locations. The median degree of a horse in the network was 33 (range: 1-105). Developing disease management strategies without the explicit consideration of horses boarded at individual home facilities would underestimate the connectivity of horses in the population. The results of this study provides information that can be used by equestrian show organizers to configure event management in such a way that can limit the extent of potential disease spread.

  11. Citizen Management of Technology: A Science and Technology Studies approach to wireless networks and urban governance trough guifi.net

    Directory of Open Access Journals (Sweden)

    Yann Bona Beauvois

    2011-03-01

    Full Text Available Thesis presented at the Departament de Psicologia Social de la UAB by Yann Bona on December, 2010. Directed by Dr. Joan Pujol Tarrés.This dissertation explores the many ways in which citizens aiming to manage technologies in urban scape relate to public administrations. To accomplish it's task, it brings forward certain STS notions such as cosmopolitics, hybrid composition or technical democracy. On a general level, this thesis seeks an answer to Bruno Latour concern with what does it mean to conceive the technical as political?. We offer a set of conclusions based on what we choose to name a Sociotechnique of Public Policy .Our work relies on a case study focused on a free and open wireless network (located in Catalunya for the most part and called guifi.net that emerged from the desire and will of Civil Society wich, up to date, turns out to be the world's biggest free wireless network.

  12. Reciprocal associations between positive emotions and motivation in daily life: Network analyses in anhedonic individuals and healthy controls.

    Science.gov (United States)

    van Roekel, Eeske; Heininga, Vera E; Vrijen, Charlotte; Snippe, Evelien; Oldehinkel, Albertine J

    2018-04-19

    Anhedonia reflects a dysfunction in the reward system, which can be manifested in an inability to enjoy pleasurable situations (i.e., lack of positive emotions), but also by a lack of motivation to engage in pleasurable activities (i.e., lack of motivation). Little is known about the interrelations between positive emotions and motivation in daily life, and whether these associations are altered in anhedonic individuals. In the present study, we used a network approach to explore the reciprocal, lagged associations between positive emotions and motivation in anhedonic individuals (N = 66) and controls (N = 68). Participants (aged between 18 and 24 years) filled out momentary assessments of affect 3 times per day for 30 consecutive days. Our results showed that (a) anhedonic individuals and controls had similar moment-to-moment transfer of positive emotions; (b) in the anhedonic network feeling cheerful was the node with the highest outstrength, both within this group and compared with the control group; (c) feeling relaxed had the highest outstrength in the control network, and (d) anhedonic individuals had stronger pathways from positive emotions to motivation than controls. Taken together, our findings suggest that low levels of positive emotions lead to decreased motivation in the anhedonic group, which could instigate a negative spiral of low pleasure and low motivation. On a more positive note, we showed that cheerfulness had the highest outstrength in the network of anhedonic participants. Hence, interventions may focus on increasing cheerfulness in anhedonic individuals, as this will likely have the greatest impact on other positive emotions and motivations. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  13. B-jet and c-jet identification with Neural Networks as well as combination of multivariate analyses for the search for of multivariate analyses for the search for single top-quark production

    Energy Technology Data Exchange (ETDEWEB)

    Renz, Manuel; /Karlsruhe U., EKP

    2008-06-01

    In the first part of this diploma thesis, the current version of the KIT Flavor Separator, a neural network which is able to distinguish between tagged b-quark jets and tagged c/light-quark jets, is presented. In comparison with previous versions four new input variables are utilized and new Monte Carlo samples with a larger number of simulated events are used for the training of the neural network. It is illustrated that the output of the neural network is continuously distributed between 1 and -1, whereas b-quark jets accumulate at 1, however, c-quark jets and light-quark jets have outputs next to -1. To ensure that the network output describes observed events correctly, the shapes of all input variables are compared in simulation and data. Thus the mismodelling of any input variable is excluded. Moreover, the b jet and light jet output distributions are compared with the output of samples of observed events, which are enhanced in the particular flavor. In contrast to previous versions, no b-jet output correction function has to be calculated, because the agreement between simulation and collision data is excellent for b-quark jets. For the light-jet output, correction functions are developed. Different applications of the KIT Flavor Separator are mentioned. For example it provides a precious input to all three CDF single top quark analyses. Furthermore, it is shown that the KIT Flavor Separator is a universal tool, which can be used in every high-p{sub T} analysis that requires the identification of b-quark jets with high efficiency. As it is pointed out, a further application is the estimation of the flavor composition of a given sample of observed events. In addition a neural network, which is able to separate c-quark jets from light-quark jets, is trained. It is shown, that all three flavors can be separated in the c-net-Flavor Separator plane. As a result, the uncertainties on the estimation of the flavor composition in events with one tagged jet are cut

  14. B-jet and c-jet identification with Neural Networks as well as combination of multivariate analyses for the search for of multivariate analyses for the search for single top-quark production

    International Nuclear Information System (INIS)

    Renz, Manuel

    2008-01-01

    In the first part of this diploma thesis, the current version of the KIT Flavor Separator, a neural network which is able to distinguish between tagged b-quark jets and tagged c/light-quark jets, is presented. In comparison with previous versions four new input variables are utilized and new Monte Carlo samples with a larger number of simulated events are used for the training of the neural network. It is illustrated that the output of the neural network is continuously distributed between 1 and -1, whereas b-quark jets accumulate at 1, however, c-quark jets and light-quark jets have outputs next to -1. To ensure that the network output describes observed events correctly, the shapes of all input variables are compared in simulation and data. Thus the mismodelling of any input variable is excluded. Moreover, the b jet and light jet output distributions are compared with the output of samples of observed events, which are enhanced in the particular flavor. In contrast to previous versions, no b-jet output correction function has to be calculated, because the agreement between simulation and collision data is excellent for b-quark jets. For the light-jet output, correction functions are developed. Different applications of the KIT Flavor Separator are mentioned. For example it provides a precious input to all three CDF single top quark analyses. Furthermore, it is shown that the KIT Flavor Separator is a universal tool, which can be used in every high-p T analysis that requires the identification of b-quark jets with high efficiency. As it is pointed out, a further application is the estimation of the flavor composition of a given sample of observed events. In addition a neural network, which is able to separate c-quark jets from light-quark jets, is trained. It is shown, that all three flavors can be separated in the c-net-Flavor Separator plane. As a result, the uncertainties on the estimation of the flavor composition in events with one tagged jet are cut into

  15. Government support of innovation

    CERN Multimedia

    Studt, T

    2003-01-01

    "One of the Federal government's few formal interagency enterprises, the Networking and Information Technology R&D (NITRD) program, is the collaborative framework of numerous federal agencies that conduct fundamental R&D in advanced networks, computing systems, software, and information management technologies" (1/2 page).

  16. Governance of Global Interorganizational Tourism Networks; Changing forms of co-ordination between the travel agency and aviation sector

    NARCIS (Netherlands)

    J.H. Appelman (Jaco)

    2004-01-01

    textabstractDe analyse van de coordinatie en evolutie van mondiale interorganisationele netwerken die het vervoer van personen regelen staan centraal in deze dissertatie. De reisagent- en luchtvaartnetwerken maken deel uit van een van de grootste en oudste mondiale economische sectoren: toerisme.

  17. Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork

    Directory of Open Access Journals (Sweden)

    Druka Arnis

    2008-11-01

    Full Text Available Abstract Background A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols, processing and the array platform. Used in concert, these data sets provide the opportunity to perform genetic analysis at a systems level. Their predictive power is largely determined by the gene expression dataset where tens of millions of data points can be generated using currently available mRNA profiling technologies. Such large, multidimensional data sets often have value beyond that extracted during their initial analysis and interpretation, particularly if conducted on widely distributed reference genetic materials. Besides quality and scale, access to the data is of primary importance as accessibility potentially allows the extraction of considerable added value from the same primary dataset by the wider research community. Although the number of genetical genomics experiments in different plant species is rapidly increasing, none to date has been presented in a form that allows quick and efficient on-line testing for possible associations between genes, loci and traits of interest by an entire research community. Description Using a reference population of 150 recombinant doubled haploid barley lines we generated novel phenotypic, mRNA abundance and SNP-based genotyping data sets, added them to a considerable volume of legacy trait data and entered them into the GeneNetwork http://www.genenetwork.org. GeneNetwork is a unified on-line analytical environment that enables the user to test genetic hypotheses about how component traits, such as mRNA abundance, may interact to condition more complex biological phenotypes (higher-order traits. Here we describe these barley data sets and demonstrate some of the functionalities GeneNetwork provides as an easily accessible and integrated analytical environment for exploring them. Conclusion By

  18. Forging a New Hegemony? The Role of Transnational Policy Groups in the Network and Discourses of Global Corporate Governance

    Directory of Open Access Journals (Sweden)

    William K. Carroll

    2015-08-01

    Full Text Available This study situates ?ve top transnational policy-planning groups within the larger structure of corporate power that is constituted through interlocking directorates among the world’s largest companies. Each group makes a distinct contribution toward transnational capitalist hegemony both by building consensus within the global corporate elite and by educating publics and states on the virtues of one or another variant of the neoliberal paradigm. Analysis of corporate-policy interlocks reveals that a few dozen cosmopolitans—primarily men based in Europe and North America and actively engaged in corporate management— knit the network together via participation in transnational interlocking and/or multiple policy groups. As a structure underwriting transnational business activism, the network is highly centralized, yet from its core it extends unevenly to corporations and individuals positioned on its fringes. The policy groups pull the directorates of the world’s major corporations together, and collaterally integrate the lifeworld of the global corporate elite, but they do so selectively, reproducing regional di?erences in participation. These ?ndings support the claim that a well-integrated global corporate elite has formed, and that global policy groups have contributed to its formation. Whether this elite con?rms the arrival of a transnational capitalist class is a matter partly of semantics and partly of substance.

  19. Joint genetic and network analyses identify loci associated with root growth under NaCl stress in Arabidopsis thaliana.

    Science.gov (United States)

    Kobayashi, Yuriko; Sadhukhan, Ayan; Tazib, Tanveer; Nakano, Yuki; Kusunoki, Kazutaka; Kamara, Mohamed; Chaffai, Radhouane; Iuchi, Satoshi; Sahoo, Lingaraj; Kobayashi, Masatomo; Hoekenga, Owen A; Koyama, Hiroyuki

    2016-04-01

    Plants have evolved a series of tolerance mechanisms to saline stress, which perturbs physiological processes throughout the plant. To identify genetic mechanisms associated with salinity tolerance, we performed linkage analysis and genome-wide association study (GWAS) on maintenance of root growth of Arabidopsis thaliana in hydroponic culture with weak and severe NaCl toxicity. The top 200 single-nucleotide polymorphisms (SNPs) determined by GWAS could cumulatively explain approximately 70% of the variation observed at each stress level. The most significant SNPs were linked to the genes of ATP-binding cassette B10 and vacuolar proton ATPase A2. Several known salinity tolerance genes such as potassium channel KAT1 and calcium sensor SOS3 were also linked to SNPs in the top 200. In parallel, we constructed a gene co-expression network to independently verify that particular groups of genes work together to a common purpose. We identify molecular mechanisms to confer salt tolerance from both predictable and novel physiological sources and validate the utility of combined genetic and network analysis. Additionally, our study indicates that the genetic architecture of salt tolerance is responsive to the severity of stress. These gene datasets are a significant information resource for a following exploration of gene function. © 2015 John Wiley & Sons Ltd.

  20. Coupled in situ Ammonium and Nitrate analyses of a tidally dominated estuary: New developments from the Elkhorn Slough Land/Ocean Biogeochemical Observatory network

    Science.gov (United States)

    Gibson, P. J.; Plant, J.; Johnson, K. S.

    2012-12-01

    For nearly nine years the Elkhorn Slough Land/Ocean Biogeochemical Observatory (LOBO) network of moorings has been delivering freely available hourly data to the web in near real time. Each mooring hosts a suite of instruments including an ISUS nitrate sensor. In addition to providing valuable information on ecosystem scale processes, the moorings serve as ideal test platforms for novel in situ chemical sensors & analyzers developed by the Monterey Bay Aquarium Research Institute. The recent addition of a newly developed in situ NH4+ analyzer, the DigiScan-II, has provided additional insights into N cycling mechanisms within the slough. The analysis method estimates NH4+ concentration via base conversion to NH3 gas and diffusion across a membrane into an acid carrier stream with subsequent conductivity detection. Although this new NH4+ analyzer is reagent based, it was developed to be relatively cheap, robust, and configurable for a range of deployment options and requires minimal, infrequent maintenance that is ultimately governed by battery life. The fundamental DigiScan-II platform can also be used for other analyses of interest, such as PO4 or CT (total inorganic carbon), by swapping the necessary reagents and components and by making minor code modifications. For deployment in Elkhorn Slough, the NH4+ DigiScan-II was configured for mid-scale concentration detection with a linear calibration range of 30.0 μM NH4+. The flux of different forms of bioavailable DIN through the system is driven by runoff inputs, tidal exchange, and biological processing. Large inputs of NO3- are sourced from the agriculturally influenced Old Salinas River (OSR), which enters the Slough near the estuary mouth and confluence with Monterey Bay. Rising ocean tides force this eutrophied water mass up into the slough where it is accessed by various biological communities during the course of the tidal period. Mass balance estimates suggest there is an imbalance between the amount of NO3

  1. Governing sex workers in Timor Leste.

    Science.gov (United States)

    Harrington, Carol

    2011-01-01

    This paper argues that international security forces in Timor Leste depend upon civilian partners in HIV/AIDs "knowledge networks" to monitor prostitutes' disease status. These networks produce mobile expertise, techniques of government and forms of personhood that facilitate international government of distant populations without overt coercion. HIV/AIDs experts promote techniques of peer education, empowerment and community mobilisation to construct women who sell sex as health conscious sex workers. Such techniques make impoverished women responsible for their disease status, obscuring the political and economic contexts that produced that status. In the militarised context of Timor Leste, knowledge of the sexual conduct of sub-populations labelled high risk circulates among global HIV/AIDs knowledge networks, confirming their expert status while obscuring the sexual harm produced by military intervention. HIV/AIDs knowledge networks have recently begun to build Timorese sex worker organisations by contracting an Australian sex worker NGO to train a Timorese NGO tasked with building sex worker identity and community. Such efforts fail to address the needs and priorities of the women supposedly empowered. The paper engages theories of global knowledge networks, mobile technologies of government, and governmentality to analyse policy documents, reports, programmes, official statements, speeches, and journalistic accounts regarding prostitution in Timor Leste.

  2. A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome.

    Science.gov (United States)

    Diepold, Andreas; Sezgin, Erdinc; Huseyin, Miles; Mortimer, Thomas; Eggeling, Christian; Armitage, Judith P

    2017-06-27

    Many bacteria use a type III secretion system (T3SS) to inject effector proteins into host cells. Selection and export of the effectors is controlled by a set of soluble proteins at the cytosolic interface of the membrane spanning type III secretion 'injectisome'. Combining fluorescence microscopy, biochemical interaction studies and fluorescence correlation spectroscopy, we show that in live Yersinia enterocolitica bacteria these soluble proteins form complexes both at the injectisome and in the cytosol. Binding to the injectisome stabilizes these cytosolic complexes, whereas the free cytosolic complexes, which include the type III secretion ATPase, constitute a highly dynamic and adaptive network. The extracellular calcium concentration, which triggers activation of the T3SS, directly influences the cytosolic complexes, possibly through the essential component SctK/YscK, revealing a potential mechanism involved in the regulation of type III secretion.

  3. Transcriptomic network analyses of leaf dehydration responses identify highly connected ABA and ethylene signaling hubs in three grapevine species differing in drought tolerance.

    Science.gov (United States)

    Hopper, Daniel W; Ghan, Ryan; Schlauch, Karen A; Cramer, Grant R

    2016-05-23

    Grapevine is a major food crop that is affected by global climate change. Consistent with field studies, dehydration assays of grapevine leaves can reveal valuable information of the plant's response at physiological, transcript, and protein levels. There are well-known differences in grapevine rootstocks responses to dehydration. We used time-series transcriptomic approaches combined with network analyses to elucidate and identify important physiological processes and network hubs that responded to dehydration in three different grapevine species differing in their drought tolerance. Transcriptomic analyses of the leaves of Cabernet Sauvignon, Riparia Gloire, and Ramsey were evaluated at different times during a 24-h controlled dehydration. Analysis of variance (ANOVA) revealed that approximately 11,000 transcripts changed significantly with respect to the genotype x treatment interaction term and approximately 6000 transcripts changed significantly according to the genotype x treatment x time interaction term indicating massive differential changes in gene expression over time. Standard analyses determined substantial effects on the transcript abundance of genes involved in the metabolism and signaling of two known plant stress hormones, abscisic acid (ABA) and ethylene. ABA and ethylene signaling maps were constructed and revealed specific changes in transcript abundance that were associated with the known drought tolerance of the genotypes including genes such as VviABI5, VviABF2, VviACS2, and VviWRKY22. Weighted-gene coexpression network analysis (WGCNA) confirmed these results. In particular, WGCNA identified 30 different modules, some of which had highly enriched gene ontology (GO) categories for photosynthesis, phenylpropanoid metabolism, ABA and ethylene signaling. The ABA signaling transcription factors, VviABI5 and VviABF2, were highly connected hubs in two modules, one being enriched in gaseous transport and the other in ethylene signaling. VviABI5 was

  4. Methodological issues in the design and analyses of neonatal research studies: Experience of the NICHD Neonatal Research Network.

    Science.gov (United States)

    Das, Abhik; Tyson, Jon; Pedroza, Claudia; Schmidt, Barbara; Gantz, Marie; Wallace, Dennis; Truog, William E; Higgins, Rosemary D

    2016-10-01

    Impressive advances in neonatology have occurred over the 30 years of life of The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN). However, substantial room for improvement remains in investigating and further developing the evidence base for improving outcomes among the extremely premature. We discuss some of the specific methodological challenges in the statistical design and analysis of randomized trials and observational studies in this population. Challenges faced by the NRN include designing trials for unusual or rare outcomes, accounting for and explaining center variations, identifying other subgroup differences, and balancing safety and efficacy concerns between short-term hospital outcomes and longer-term neurodevelopmental outcomes. In conclusion, the constellation of unique patient characteristics in neonates calls for broad understanding and careful consideration of the issues identified in this article for conducting rigorous studies in this population. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Clinical trials with new oral anticoagulants. Additive value of indirect comparisons also named network meta-analyses.

    Science.gov (United States)

    Harenberg, J; Weiss, C

    2013-01-01

    To compare the efficacy and safety of the new oral anticoagulants (NOAC), ideally head-to-head clinical trials should be performed. Given the expense of such an undertaking, it is highly unlikely that such a comparison would be performed. Therefore, there is a need for an unbiased comparative assessment of the benefits and risks of the NOACs, based on the available trial data. Indirect or mixed treatment comparisons may be an useful tool to overcome these limitations also known as network meta-analysis (NMA). The aim of this paper is to give an overview on published NMAs for dabigatran, rivaroxaban and apixaban, each assessed against warfarin in patients with atrial fibrillation, and against enoxaparin in patients undergoing total knee and total hip replacement surgery, in order to obtain insights into the comparability of the adopted methodological techniques.

  6. Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses.

    Science.gov (United States)

    Amin, Amr; Hamza, Alaaeldin A; Daoud, Sayel; Khazanehdari, Kamal; Hrout, Ala'a Al; Baig, Badriya; Chaiboonchoe, Amphun; Adrian, Thomas E; Zaki, Nazar; Salehi-Ashtiani, Kourosh

    2016-01-01

    The angiogenesis inhibitor, sorafenib, remains the only available therapy of hepatocellular carcinoma (HCC). Only recently patents of VEGF receptors-3 inhibitors are developed. Thus, a novel approach against HCC is essential for a better therapeutic outcome. The aims of this study were to examine the chemopreventive action of saffron's main biomolecule, crocin, against chemically-induced liver cancer in rats, and to explore the mechanisms by which crocin employs its anti-tumor effects. We investigated the anti-cancer effect of crocin on an experimental carcinogenesis model of liver cancer by studying the anti-oxidant, anti-inflammatory, anti-proliferation, pro-apoptotic activities of crocin in vivo. In addition, we provided a network analysis of differentially expressed genes in tissues of animals pre-treated with crocin in comparison to induced-HCC animals' tissues. To further support our results, in vitro analysis was carried out. We assessed the effects of crocin on HepG2 cells viability by treating them with various concentrations of crocin; in addition, effects of crocin on cell cycle distribution of HepG2 cells were investigated. Findings reported herein demonstrated the anti-proliferative and pro-apoptotic properties of crocin when administrated in induced- HCC model. Crocin exhibited anti-inflammatory properties where NF-κB, among other inflammatory markers, was inhibited. In vitro analysis confirmed crocin's effect in HepG2 by arresting the cell cycle at S and G2/M phases, inducing apoptosis and down regulating inflammation. Network analysis identified NF-κB as a potential regulatory hub, and therefore, a candidate therapeutic drug target. Taken together, our findings introduce crocin as a candidate chemopreventive agent against HCC.

  7. The TCA Pathway is an Important Player in the Regulatory Network Governing Vibrio alginolyticus Adhesion Under Adversity.

    Science.gov (United States)

    Huang, Lixing; Huang, Li; Yan, Qingpi; Qin, Yingxue; Ma, Ying; Lin, Mao; Xu, Xiaojin; Zheng, Jiang

    2016-01-01

    Adhesion is a critical step in the initial stage of Vibrio alginolyticus infection; therefore, it is important to understand the underlying mechanisms governing the adhesion of V. alginolyticus and determine if environmental factors have any effect. A greater understanding of this process may assist in developing preventive measures for reducing infection. In our previous research, we presented the first RNA-seq data from V. alginolyticus cultured under stress conditions that resulted in reduced adhesion. Based on the RNA-seq data, we found that the Tricarboxylic acid cycle (TCA pathway) might be closely related to adhesion. Environmental interactions with the TCA pathway might alter adhesion. To validate this, bioinformatics analysis, quantitative Real-Time PCR (qPCR), RNAi, and in vitro adhesion assays were performed, while V. alginolyticus was treated with various stresses including temperature, pH, salinity, and starvation. The expression of genes involved in the TCA pathway was confirmed by qPCR, which reinforced the reliability of the sequencing data. Silencing of these genes was capable of reducing the adhesion ability of V. alginolyticus. Adhesion of V. alginolyticus is influenced substantially by environmental factors and the TCA pathway is sensitive to some environmental stresses, especially changes in pH and starvation. Our results indicated that (1) the TCA pathway plays a key role in V. alginolyticus adhesion: (2) the TCA pathway is sensitive to environmental stresses.

  8. The TCA pathway is an important player in the regulatory network governing Vibrio alginolyticus adhesion under adversity

    Directory of Open Access Journals (Sweden)

    Lixing eHuang

    2016-02-01

    Full Text Available Adhesion is a critical step in the initial stage of Vibrio alginolyticus infection; therefore, it is important to understand the underlying mechanisms governing the adhesion of V. alginolyticus and determine if environmental factors have any effect. A greater understanding of this process may assist in developing preventive measures for reducing infection. In our previous research, we presented the first RNA-seq data from V. alginolyticus cultured under stress conditions that resulted in reduced adhesion. Based on the RNA-seq data, we found that the Tricarboxylic acid cycle (TCA pathway might be closely related to adhesion. Environmental interactions with the TCA pathway might alter adhesion. To validate this, bioinformatics analysis, qPCR, RNAi and in vitro adhesion assays were performed, while V. alginolyticus was treated with various stresses including temperature, pH, salinity and starvation. The expression of genes involved in the TCA pathway was confirmed by qPCR, which reinforced the reliability of the sequencing data. Silencing of these genes was capable of reducing the adhesion ability of V. alginolyticus. Adhesion of V. alginolyticus is influenced substantially by environmental factors and the TCA pathway is sensitive to some environmental stresses, especially changes in pH and starvation. Our results indicated that 1 the TCA pathway plays a key role in V. alginolyticus adhesion: 2 the TCA pathway is sensitive to environmental stresses.

  9. Hydrologic and geochemical factors governing chemical evolution of discharges from an abandoned, flooded, underground coal mine network

    Energy Technology Data Exchange (ETDEWEB)

    McDonough, K.M.; Lambert, D.C.; Mugunthan, P.; Dzombak, D.A. [Carnegie Mellon University, Pittsburgh, PA (US). Dept. of Civil and Environmental Engineering

    2005-04-01

    Discharges from some underground flooded coal mines have exhibited increases in pH and reductions in contaminant loadings with time. Data from a study of mine water quality evolution in interconnected, flooded mines of the Uniontown syncline, Southwestern Pennsylvania were evaluated with the aid of modeling to elucidate the hydrologic and geochemical factors responsible for such changes. Coal barriers left in place from mining operations define three hydraulically distinct but interconnected zones: the southern, central, and northern pools. Assuming each mine pool to behave as a completely mixed tank reactor, a steady-state, tanks-in-series model was developed to describe system hydraulics. Chemical modeling components were coupled with the tank reactor hydraulic model to simulate inputs to the mine voids, acid generation from pyrite dissolution, and discharge water quality. Empirical in-mine chemical production terms were estimated for each of the mine pools based on discharge data from 1974 to 1975 and 1998 to 2000. The production terms were then used to simulate discharge water quality for each of the mine pools over a 50 year period. Simulated water quality in the northern and central mine pools reached steady-state conditions approximately 25-30 years after the mine pools flooded, evolving over time to reflect the recharge water quality. The simulation results indicate that the evolution of mine water quality in the flooded mine voids has been governed by alkaline recharge water slowly displacing acidic 'first flush' water.

  10. Effects of Using High-Density Rain Gauge Networks and Weather Radar Data on Urban Hydrological Analyses

    Directory of Open Access Journals (Sweden)

    Seong-Sim Yoon

    2017-11-01

    Full Text Available Flood prediction is difficult in urban areas because only sparse gauge data and radar data of low accuracy are usually used to analyze flooding and inundation. Sub-basins of urban areas are extremely small, so rainfall data of high spatial resolution are required for analyzing complex drainage systems with high spatial variability. This study aimed to produce three types of quantitative precipitation estimation (QPE products using rainfall data that was derived from 190 gauges, including the new high-density rain-gauge network operated by the SK Planet company, and the automated weather stations of the Korea Meteorological Administration, along with weather radar data. This study also simulated urban runoff for the Gangnam District of Seoul, South Korea, using the obtained QPE products to evaluate hydraulic and hydrologic impacts according to three rainfall fields. The accuracy of this approach was assessed in terms of the amount and spatial distribution of rainfall in an urban area. The QPE products provided highly accurate results and simulations of peak runoff and overflow phenomena. They also accurately described the spatial variability of the rainfall fields. Overall, the integration of high-density gauge data with radar data proved beneficial for quantitative rainfall estimation.

  11. Heat transfer entropy resistance for the analyses of two-stream heat exchangers and two-stream heat exchanger networks

    International Nuclear Information System (INIS)

    Cheng, XueTao; Liang, XinGang

    2013-01-01

    The entropy generation minimization method is often used to analyze heat transfer processes from the thermodynamic viewpoint. In this paper, we analyze common heat transfer processes with the concept of entropy generation, and propose the concept of heat transfer entropy resistance. It is found that smaller heat transfer entropy resistance leads to smaller equivalent thermodynamic force difference with prescribed heat transfer rate and larger heat transfer rate with prescribed equivalent thermodynamic force difference. With the concept of heat transfer entropy resistance, the performance of two-stream heat exchangers (THEs) and two-stream heat exchanger networks (THENs) is analyzed. For the cases discussed in this paper, it is found that smaller heat transfer entropy resistance always leads to better heat transfer performance for THEs and THENs, while smaller values of the entropy generation, entropy generation numbers and revised entropy generation number do not always. -- Highlights: • The concept of entropy resistance is defined. • The minimum entropy resistance principle is developed. • Smaller entropy resistance leads to better heat transfer

  12. Comparison of pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a protocol for a systematic review incorporating network meta-analyses.

    Science.gov (United States)

    Burry, L D; Hutton, B; Guenette, M; Williamson, D; Mehta, S; Egerod, I; Kanji, S; Adhikari, N K; Moher, D; Martin, C M; Rose, L

    2016-09-08

    Delirium is characterized by acute changes in mental status including inattention, disorganized thinking, and altered level of consciousness, and is highly prevalent in critically ill adults. Delirium has adverse consequences for both patients and the healthcare system; however, at this time, no effective treatment exists. The identification of effective prevention strategies is therefore a clinical and research imperative. An important limitation of previous reviews of delirium prevention is that interventions were considered in isolation and only direct evidence was used. Our systematic review will synthesize all existing data using network meta-analysis, a powerful statistical approach that enables synthesis of both direct and indirect evidence. We will search Ovid MEDLINE, CINAHL, Embase, PsycINFO, and Web of Science from 1980 to March 2016. We will search the PROSPERO registry for protocols and the Cochrane Library for published systematic reviews. We will examine reference lists of pertinent reviews and search grey literature and the International Clinical Trials Registry Platform for unpublished studies and ongoing trials. We will include randomized and quasi-randomized trials of critically ill adults evaluating any pharmacological, non-pharmacological, or multi-component intervention for delirium prevention, administered in or prior to (i.e., peri-operatively) transfer to the ICU. Two authors will independently screen search results and extract data from eligible studies. Risk of bias assessments will be completed on all included studies. To inform our network meta-analysis, we will first conduct conventional pair-wise meta-analyses for primary and secondary outcomes using random-effects models. We will generate our network meta-analysis using a Bayesian framework, assuming a common heterogeneity parameter across all comparisons, and accounting for correlations in multi-arm studies. We will perform analyses using WinBUGS software. This systematic review

  13. Microbial Rhodopsin Optogenetic Tools: Application for Analyses of Synaptic Transmission and of Neuronal Network Activity in Behavior.

    Science.gov (United States)

    Glock, Caspar; Nagpal, Jatin; Gottschalk, Alexander

    2015-01-01

    Optogenetics was introduced as a new technology in the neurosciences about a decade ago (Zemelman et al., Neuron 33:15-22, 2002; Boyden et al., Nat Neurosci 8:1263-1268, 2005; Nagel et al., Curr Biol 15:2279-2284, 2005; Zemelman et al., Proc Natl Acad Sci USA 100:1352-1357, 2003). It combines optics, genetics, and bioengineering to render neurons sensitive to light, in order to achieve a precise, exogenous, and noninvasive control of membrane potential, intracellular signaling, network activity, or behavior (Rein and Deussing, Mol Genet Genomics 287:95-109, 2012; Yizhar et al., Neuron 71:9-34, 2011). As C. elegans is transparent, genetically amenable, has a small nervous system mapped with synapse resolution, and exhibits a rich behavioral repertoire, it is especially open to optogenetic methods (White et al., Philos Trans R Soc Lond B Biol Sci 314:1-340, 1986; De Bono et al., Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans, In: Hegemann P, Sigrist SJ (eds) Optogenetics, De Gruyter, Berlin, 2013; Husson et al., Biol Cell 105:235-250, 2013; Xu and Kim, Nat Rev Genet 12:793-801, 2011). Optogenetics, by now an "exploding" field, comprises a repertoire of different tools ranging from transgenically expressed photo-sensor proteins (Boyden et al., Nat Neurosci 8:1263-1268, 2005; Nagel et al., Curr Biol 15:2279-2284, 2005) or cascades (Zemelman et al., Neuron 33:15-22, 2002) to chemical biology approaches, using photochromic ligands of endogenous channels (Szobota et al., Neuron 54:535-545, 2007). Here, we will focus only on optogenetics utilizing microbial rhodopsins, as these are most easily and most widely applied in C. elegans. For other optogenetic tools, for example the photoactivated adenylyl cyclases (PACs, that drive neuronal activity by increasing synaptic vesicle priming, thus exaggerating rather than overriding the intrinsic activity of a neuron, as occurs with

  14. Proteomic, cellular, and network analyses reveal new DUSP3 interactions with nucleolar proteins in HeLa cells.

    Science.gov (United States)

    Panico, Karine; Forti, Fabio Luis

    2013-12-06

    DUSP3 (or Vaccinia virus phosphatase VH1-related; VHR) is a small dual-specificity phosphatase known to dephosphorylate c-Jun N-terminal kinases and extracellular signal-regulated kinases. In human cervical cancer cells, DUSP3 is overexpressed, localizes preferentially to the nucleus, and plays a key role in cellular proliferation and senescence triggering. Other DUSP3 functions are still unknown, as illustrated by recent and unpublished results from our group showing that this enzyme mediates DNA damage response or repair processes. In this study, we sought to identify new interactions between DUSP3 and proteins directly or indirectly involved in or correlated with its biological roles in HeLa cells exposed to gamma or UV radiation. By using GST-DUSP as bait, we pulled down interacting proteins and identified them by LC-MS/MS. Of the 46 proteins obtained, six hits were extensively validated by immune techniques; the proteins Nucleophosmin, HnRNP C1/C2, and Nucleolin were the most promising targets found to directly interact with DUSP3. We then analyzed the DUSP3 interactomes using physical protein-protein interaction networks using our hits as the seed list. The validated hits as well as unvalidated hits fluctuated on the DUSP3 interactomes of HeLa cells, independent of the time post radiation, which confirmed our proteomic and experimental data and clearly showed the proximity of DUSP3 to proteins involved in processes intimately related to DNA repair and senescence, such as Ku70 and Tert, via interactions with nucleolar proteins, which were identified in this study, that regulate DNA/RNA structure and functions.

  15. Interactive governance

    DEFF Research Database (Denmark)

    Sørensen, Eva; Torfing, Jacob; Peters, B. Guy

    , but all these forms represent means of governing involving mixtures of state action with the actions of other entities.This book explores thoroughly this meaning of governance, and links it to broader questions of governance. In the process of explicating this dimension of governance the authors also...... explore some of the more fundamental questions about governance theory. For example, although governance is talked about a great deal political science has done relatively little about how to measure this concept. Likewise, the term multi-level governance has become widely used but its important...... to understand that idea more fully and see how it functions in the context of interactive forms of governance. The authors also link governance to some very fundamental questions in political science and the social sciences more broadly. How is power exercised in interactive governance? How democratic...

  16. Divergent and convergent modes of interaction between wheat and Puccinia graminis f. sp. tritici isolates revealed by the comparative gene co-expression network and genome analyses.

    Science.gov (United States)

    Rutter, William B; Salcedo, Andres; Akhunova, Alina; He, Fei; Wang, Shichen; Liang, Hanquan; Bowden, Robert L; Akhunov, Eduard

    2017-04-12

    Two opposing evolutionary constraints exert pressure on plant pathogens: one to diversify virulence factors in order to evade plant defenses, and the other to retain virulence factors critical for maintaining a compatible interaction with the plant host. To better understand how the diversified arsenals of fungal genes promote interaction with the same compatible wheat line, we performed a comparative genomic analysis of two North American isolates of Puccinia graminis f. sp. tritici (Pgt). The patterns of inter-isolate divergence in the secreted candidate effector genes were compared with the levels of conservation and divergence of plant-pathogen gene co-expression networks (GCN) developed for each isolate. Comprative genomic analyses revealed substantial level of interisolate divergence in effector gene complement and sequence divergence. Gene Ontology (GO) analyses of the conserved and unique parts of the isolate-specific GCNs identified a number of conserved host pathways targeted by both isolates. Interestingly, the degree of inter-isolate sub-network conservation varied widely for the different host pathways and was positively associated with the proportion of conserved effector candidates associated with each sub-network. While different Pgt isolates tended to exploit similar wheat pathways for infection, the mode of plant-pathogen interaction varied for different pathways with some pathways being associated with the conserved set of effectors and others being linked with the diverged or isolate-specific effectors. Our data suggest that at the intra-species level pathogen populations likely maintain divergent sets of effectors capable of targeting the same plant host pathways. This functional redundancy may play an important role in the dynamic of the "arms-race" between host and pathogen serving as the basis for diverse virulence strategies and creating conditions where mutations in certain effector groups will not have a major effect on the pathogen

  17. Unraveling Fungal Radiation Resistance Regulatory Networks through the Genome-Wide Transcriptome and Genetic Analyses of Cryptococcus neoformans

    Science.gov (United States)

    Jung, Kwang-Woo; Yang, Dong-Hoon; Kim, Min-Kyu; Seo, Ho Seong

    2016-01-01

    ABSTRACT The basidiomycetous fungus Cryptococcus neoformans has been known to be highly radiation resistant and has been found in fatal radioactive environments such as the damaged nuclear reactor at Chernobyl. To elucidate the mechanisms underlying the radiation resistance phenotype of C. neoformans, we identified genes affected by gamma radiation through genome-wide transcriptome analysis and characterized their functions. We found that genes involved in DNA damage repair systems were upregulated in response to gamma radiation. Particularly, deletion of recombinase RAD51 and two DNA-dependent ATPase genes, RAD54 and RDH54, increased cellular susceptibility to both gamma radiation and DNA-damaging agents. A variety of oxidative stress response genes were also upregulated. Among them, sulfiredoxin contributed to gamma radiation resistance in a peroxiredoxin/thioredoxin-independent manner. Furthermore, we found that genes involved in molecular chaperone expression, ubiquitination systems, and autophagy were induced, whereas genes involved in the biosynthesis of proteins and fatty acids/sterols were downregulated. Most importantly, we discovered a number of novel C. neoformans genes, the expression of which was modulated by gamma radiation exposure, and their deletion rendered cells susceptible to gamma radiation exposure, as well as DNA damage insults. Among these genes, we found that a unique transcription factor containing the basic leucine zipper domain, named Bdr1, served as a regulator of the gamma radiation resistance of C. neoformans by controlling expression of DNA repair genes, and its expression was regulated by the evolutionarily conserved DNA damage response protein kinase Rad53. Taken together, the current transcriptome and functional analyses contribute to the understanding of the unique molecular mechanism of the radiation-resistant fungus C. neoformans. PMID:27899501

  18. Institutionalizing Global Governance

    DEFF Research Database (Denmark)

    Rasche, Andreas; Gilbert, Dirk Ulrich

    2012-01-01

    The United Nations Global Compact – which is a Global Public Policy Network advocating 10 universal principles in the areas of human rights, labor standards, environmental protection, and anticorruption – has turned into the world's largest corporate responsibility initiative. Although the Global...... Compact is often characterized as a promising way to address global governance gaps, it remains largely unclear why this is the case. To address this problem, we discuss to what extent the initiative represents an institutional solution to exercise global governance. We suggest that new governance modes......, which have arisen in the context of globalization, often adopt a multiactor, multilevel, and network-based approach. We then analyze how far the Global Compact's institutional design reflects this multiactor, multilevel, and network-based steering mode. Drawing on this discussion, we offer suggestions...

  19. Communicating transparancy : a genre network approach : how do corporate governance codes - the SOX and the Tabaksblad Code - affect Dutch cross-listed companies' corporate communication?

    NARCIS (Netherlands)

    Laval, S.C.

    2010-01-01

    The financial scandals around 2000 caused the need for changes in the corporate governance systems. The consequence was the establishment of the US Sarbanes-Oxley Act and the Dutch Tabaksblat Code. These corporate governance codes include rules for 'good governance'. The goal of 'good governance' is

  20. Metal and physico-chemical variations at a hydroelectric reservoir analyzed by Multivariate Analyses and Artificial Neural Networks: environmental management and policy/decision-making tools.

    Science.gov (United States)

    Cavalcante, Y L; Hauser-Davis, R A; Saraiva, A C F; Brandão, I L S; Oliveira, T F; Silveira, A M

    2013-01-01

    This paper compared and evaluated seasonal variations in physico-chemical parameters and metals at a hydroelectric power station reservoir by applying Multivariate Analyses and Artificial Neural Networks (ANN) statistical techniques. A Factor Analysis was used to reduce the number of variables: the first factor was composed of elements Ca, K, Mg and Na, and the second by Chemical Oxygen Demand. The ANN showed 100% correct classifications in training and validation samples. Physico-chemical analyses showed that water pH values were not statistically different between the dry and rainy seasons, while temperature, conductivity, alkalinity, ammonia and DO were higher in the dry period. TSS, hardness and COD, on the other hand, were higher during the rainy season. The statistical analyses showed that Ca, K, Mg and Na are directly connected to the Chemical Oxygen Demand, which indicates a possibility of their input into the reservoir system by domestic sewage and agricultural run-offs. These statistical applications, thus, are also relevant in cases of environmental management and policy decision-making processes, to identify which factors should be further studied and/or modified to recover degraded or contaminated water bodies. Copyright © 2012 Elsevier B.V. All rights reserved.

  1. Self-government of complex reading and writing brains informed by cingulo-opercular network for adaptive control and working memory components for language learning.

    Science.gov (United States)

    Richards, Todd L; Abbott, Robert D; Yagle, Kevin; Peterson, Dan; Raskind, Wendy; Berninger, Virginia W

    2017-01-01

    To understand mental self-government of the developing reading and writing brain, correlations of clustering coefficients on fMRI reading or writing tasks with BASC 2 Adaptivity ratings (time 1 only) or working memory components (time 1 before and time 2 after instruction previously shown to improve achievement and change magnitude of fMRI connectivity) were investigated in 39 students in grades 4 to 9 who varied along a continuum of reading and writing skills. A Philips 3T scanner measured connectivity during six leveled fMRI reading tasks (subword-letters and sounds, word-word-specific spellings or affixed words, syntax comprehension-with and without homonym foils or with and without affix foils, and text comprehension) and three fMRI writing tasks-writing next letter in alphabet, adding missing letter in word spelling, and planning for composing. The Brain Connectivity Toolbox generated clustering coefficients based on the cingulo-opercular (CO) network; after controlling for multiple comparisons and movement, significant fMRI connectivity clustering coefficients for CO were identified in 8 brain regions bilaterally (cingulate gyrus, superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, superior temporal gyrus, insula, cingulum-cingulate gyrus, and cingulum-hippocampus). BASC2 Parent Ratings for Adaptivity were correlated with CO clustering coefficients on three reading tasks (letter-sound, word affix judgments and sentence comprehension) and one writing task (writing next letter in alphabet). Before instruction, each behavioral working memory measure (phonology, orthography, morphology, and syntax coding, phonological and orthographic loops for integrating internal language and output codes, and supervisory focused and switching attention) correlated significantly with at least one CO clustering coefficient. After instruction, the patterning of correlations changed with new correlations emerging. Results show that the reading and writing brain

  2. Petrol governance

    Energy Technology Data Exchange (ETDEWEB)

    Taminau, Y.; Vliet, M. van [Erasmus Univ., Rotterdam (Netherlands). Dept. of Public Management

    1995-12-31

    As the limits of the earth`s carrying capacity come to show, increasing pressure is brought to bear on private enterprise to behave in more environmentally responsible ways. One of the rare studies, that not only focuses on the enterprise level of analyse but at the industrial chain of production is Integrated Production Chain Management (IPCM), which postulates that the chain needs to be modified in its entirety. IPCM is not just a technical coordination problem but also a organizational problem in which different interests of actors play a role. These interests must be analysed. The present article will not go into the technical bottlenecks but will go into organizational bottlenecks that are the result of conflicts of interests. The choice between different technological options is not seen as a merely `technical` one but rather as a choice between different socio-technical (sub)systems. This choice is made in an interaction process in a network of various actors, each with their own perceptions and their own interests, in situations in which information is far from conclusive. (author)

  3. Governing education

    NARCIS (Netherlands)

    Ria Bronneman-Helmers

    2011-01-01

    Governing education. Trends in Dutch education policy 1990-2010 The Dutch government is responsible for e a cohesive and properly functioning education system. This report discusses the way in which the government fulfilled that responsibility in the period 1990-2010.  The study is

  4. Theories of the deep: combining salience and network analyses to produce mental model visualizations of a coastal British Columbia food web

    Directory of Open Access Journals (Sweden)

    Jordan Levine

    2015-12-01

    Full Text Available Arriving at shared mental models among multiple stakeholder groups can be crucial for successful management of contested social-ecological systems (SES. Academia can help by first eliciting stakeholders' initial, often tacit, beliefs about a SES, and representing them in useful ways. We demonstrate a new recombination of techniques for this purpose, focusing specifically on tacit beliefs about food webs. Our approach combines freelisting and sorting techniques, salience analysis, and ultimately network analysis, to produce accessible visualizations of aggregate mental models that can then be used to facilitate discussion or generate further hypotheses about cognitive drivers of conflict. The case study we draw upon to demonstrate this technique is Clayoquot Sound UNESCO Biosphere Reserve, on the west coast of British Columbia, Canada. There, an immanent upsurge in the sea otter (Enhydra lutris population, which competes with humans for shellfish, has produced tension among government managers, and both First Nations and non-First Nations residents. Our approach helps explain this tension by visually highlighting which trophic relationships appear most cognitively salient among the lay public. We also include speculative representations of models held by managers, and pairs of contrasting demographic subgroups, to further demonstrate potential uses of the method.

  5. Plural Governance

    DEFF Research Database (Denmark)

    Mols, Niels Peter; Menard, Claude

    2014-01-01

    Plural governance is a form of governance where a firm both makes and buys similar goods or services. Despite a widespread use of plural governance there are no transaction cost models of how plural governance affects performance. This paper reviews the literature about plural forms and proposes...... a model relating transaction cost and resource-based variables to the cost of the plural form. The model is then used to analyze when the plural form is efficient compared to alternative governance structures. We also use the model to discuss the strength of three plural form synergies....

  6. Program governance

    CERN Document Server

    Khan, Muhammad Ehsan

    2014-01-01

    FOUNDATION OF GOVERNANCEGovernanceDefining GovernanceGovernance at Multiple LevelsSummaryReferencesTransaction Cost EconomicsTransactions-Core Elements and Attributes     Behavioral Assumptions     Governance Structure AttributesHazards of Concern     Incomplete Contracting     Bilateral Dependency and Fundamental Transformation     Adaptation or MaladaptationLinking Governance, Governance Structures, and ContractsThe Impact of Asset Specificity and Behavioral Assumptions on ContractsAp

  7. A network of networks.

    Science.gov (United States)

    Iedema, Rick; Verma, Raj; Wutzke, Sonia; Lyons, Nigel; McCaughan, Brian

    2017-04-10

    Purpose To further our insight into the role of networks in health system reform, the purpose of this paper is to investigate how one agency, the NSW Agency for Clinical Innovation (ACI), and the multiple networks and enabling resources that it encompasses, govern, manage and extend the potential of networks for healthcare practice improvement. Design/methodology/approach This is a case study investigation which took place over ten months through the first author's participation in network activities and discussions with the agency's staff about their main objectives, challenges and achievements, and with selected services around the state of New South Wales to understand the agency's implementation and large system transformation activities. Findings The paper demonstrates that ACI accommodates multiple networks whose oversight structures, self-organisation and systems change approaches combined in dynamic ways, effectively yield a diversity of network governances. Further, ACI bears out a paradox of "centralised decentralisation", co-locating agents of innovation with networks of implementation and evaluation expertise. This arrangement strengthens and legitimates the role of the strategic hybrid - the healthcare professional in pursuit of change and improvement, and enhances their influence and impact on the wider system. Research limitations/implications While focussing the case study on one agency only, this study is unique as it highlights inter-network connections. Contributing to the literature on network governance, this paper identifies ACI as a "network of networks" through which resources, expectations and stakeholder dynamics are dynamically and flexibly mediated and enhanced. Practical implications The co-location of and dynamic interaction among clinical networks may create synergies among networks, nurture "strategic hybrids", and enhance the impact of network activities on health system reform. Social implications Network governance requires more

  8. Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs.

    Science.gov (United States)

    Ballester, Maria; Ramayo-Caldas, Yuliaxis; Revilla, Manuel; Corominas, Jordi; Castelló, Anna; Estellé, Jordi; Fernández, Ana I; Folch, Josep M

    2017-04-19

    In the present study, liver co-expression networks and expression Genome Wide Association Study (eGWAS) were performed to identify DNA variants and molecular pathways implicated in the functional regulatory mechanisms of meat quality traits in pigs. With this purpose, the liver mRNA expression of 44 candidates genes related with lipid metabolism was analysed in 111 Iberian x Landrace backcross animals. The eGWAS identified 92 eSNPs located in seven chromosomal regions and associated with eight genes: CROT, CYP2U1, DGAT1, EGF, FABP1, FABP5, PLA2G12A, and PPARA. Remarkably, cis-eSNPs associated with FABP1 gene expression which may be determining the C18:2(n-6)/C18:3(n-3) ratio in backfat through the multiple interaction of DNA variants and genes were identified. Furthermore, a hotspot on SSC8 associated with the gene expression of eight genes was identified and the TBCK gene was pointed out as candidate gene regulating it. Our results also suggested that the PI3K-Akt-mTOR pathway plays an important role in the control of the analysed genes highlighting nuclear receptors as the NR3C1 or PPARA. Finally, sex-dimorphism associated with hepatic lipid metabolism was identified with over-representation of female-biased genes. These results increase our knowledge of the genetic architecture underlying fat composition traits.

  9. The core regulatory network of the abscisic acid pathway in banana: genome-wide identification and expression analyses during development, ripening, and abiotic stress.

    Science.gov (United States)

    Hu, Wei; Yan, Yan; Shi, Haitao; Liu, Juhua; Miao, Hongxia; Tie, Weiwei; Ding, Zehong; Ding, XuPo; Wu, Chunlai; Liu, Yang; Wang, Jiashui; Xu, Biyu; Jin, Zhiqiang

    2017-08-29

    Abscisic acid (ABA) signaling plays a crucial role in developmental and environmental adaptation processes of plants. However, the PYL-PP2C-SnRK2 families that function as the core components of ABA signaling are not well understood in banana. In the present study, 24 PYL, 87 PP2C, and 11 SnRK2 genes were identified from banana, which was further supported by evolutionary relationships, conserved motif and gene structure analyses. The comprehensive transcriptomic analyses showed that banana PYL-PP2C-SnRK2 genes are involved in tissue development, fruit development and ripening, and response to abiotic stress in two cultivated varieties. Moreover, comparative expression analyses of PYL-PP2C-SnRK2 genes between BaXi Jiao (BX) and Fen Jiao (FJ) revealed that PYL-PP2C-SnRK2-mediated ABA signaling might positively regulate banana fruit ripening and tolerance to cold, salt, and osmotic stresses. Finally, interaction networks and co-expression assays demonstrated that the core components of ABA signaling were more active in FJ than in BX in response to abiotic stress, further supporting the crucial role of the genes in tolerance to abiotic stress in banana. This study provides new insights into the complicated transcriptional control of PYL-PP2C-SnRK2 genes, improves the understanding of PYL-PP2C-SnRK2-mediated ABA signaling in the regulation of fruit development, ripening, and response to abiotic stress, and identifies some candidate genes for genetic improvement of banana.

  10. Governance theory as a framework for empirical research. A case study on local environmental policy-making in Helsinki, Finland

    Energy Technology Data Exchange (ETDEWEB)

    Toikka, A.

    2011-07-01

    Governance has been one of the most popular buzzwords in recent political science. As with any term shared by numerous fields of research, as well as everyday language, governance is encumbered by a jungle of definitions and applications. This work elaborates on the concept of network governance. Network governance refers to complex policy-making situations, where a variety of public and private actors collaborate in order to produce and define policy. Governance is processes of autonomous, self-organizing networks of organizations exchanging information and deliberating. Network governance is a theoretical concept that corresponds to an empirical phenomenon. Often, this phenomenon is used to describe a historical development: governance is often used to describe changes in political processes of Western societies since the 1980s. In this work, empirical governance networks are used as an organizing framework, and the concepts of autonomy, self-organization and network structure are developed as tools for empirical analysis of any complex decision-making process. This work develops this framework and explores the governance networks in the case of environmental policy-making in the City of Helsinki, Finland. The crafting of a local ecological sustainability programme required support and knowledge from all sectors of administration, a number of entrepreneurs and companies and the inhabitants of Helsinki. The policy process relied explicitly on networking, with public and private actors collaborating to design policy instruments. Communication between individual organizations led to the development of network structures and patterns. This research analyses these patterns and their effects on policy choice, by applying the methods of social network analysis. A variety of social network analysis methods are used to uncover different features of the networked process. Links between individual network positions, network subgroup structures and macro-level network

  11. The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review with network meta-analyses of randomised trials.

    Directory of Open Access Journals (Sweden)

    Ferrán Catalá-López

    Full Text Available Attention deficit hyperactivity disorder (ADHD is one of the most commonly diagnosed psychiatric disorders in childhood. A wide variety of treatments have been used for the management of ADHD. We aimed to compare the efficacy and safety of pharmacological, psychological and complementary and alternative medicine interventions for the treatment of ADHD in children and adolescents.We performed a systematic review with network meta-analyses. Randomised controlled trials (≥ 3 weeks follow-up were identified from published and unpublished sources through searches in PubMed and the Cochrane Library (up to April 7, 2016. Interventions of interest were pharmacological (stimulants, non-stimulants, antidepressants, antipsychotics, and other unlicensed drugs, psychological (behavioural, cognitive training and neurofeedback and complementary and alternative medicine (dietary therapy, fatty acids, amino acids, minerals, herbal therapy, homeopathy, and physical activity. The primary outcomes were efficacy (treatment response and acceptability (all-cause discontinuation. Secondary outcomes included discontinuation due to adverse events (tolerability, as well as serious adverse events and specific adverse events. Random-effects Bayesian network meta-analyses were conducted to obtain estimates as odds ratios (ORs with 95% credibility intervals. We analysed interventions by class and individually. 190 randomised trials (52 different interventions grouped in 32 therapeutic classes that enrolled 26114 participants with ADHD were included in complex networks. At the class level, behavioural therapy (alone or in combination with stimulants, stimulants, and non-stimulant seemed significantly more efficacious than placebo. Behavioural therapy in combination with stimulants seemed superior to stimulants or non-stimulants. Stimulants seemed superior to behavioural therapy, cognitive training and non-stimulants. Behavioural therapy, stimulants and their combination

  12. Hard and Soft Governance

    DEFF Research Database (Denmark)

    Moos, Lejf

    2009-01-01

    The governance and leadership at transnational, national and school level seem to be converging into a number of isomorphic forms as we see a tendency towards substituting 'hard' forms of governance, that are legally binding, with 'soft' forms based on persuasion and advice. This article analyses...... of Denmark, and finally the third layer: the leadership used in Danish schools. The use of 'soft governance' is shifting the focus of governance and leadership from decisions towards influence and power and thus shifting the focus of the processes from the decision-making itself towards more focus...... the understanding of relations and the coherence of processes of influence/power/governance, the article introduces a communications model of decision-making processes as processes of influence....

  13. Enabling policy planning and innovation management through patent information and co-authorship network analyses: a study of tuberculosis in Brazil.

    Science.gov (United States)

    Vasconcellos, Alexandre Guimarães; Morel, Carlos Medicis

    2012-01-01

    New tools and approaches are necessary to facilitate public policy planning and foster the management of innovation in countries' public health systems. To this end, an understanding of the integrated way in which the various actors who produce scientific knowledge and inventions in technological areas of interest operate, where they are located and how they relate to one another is of great relevance. Tuberculosis has been chosen as a model for the present study as it is a current challenge for Brazilian research and innovation. Publications about tuberculosis written by Brazilian authors were accessed from international databases, analyzed, processed with text searching tools and networks of coauthors were constructed and visualized. Patent applications about tuberculosis in Brazil were retrieved from the Brazilian National Institute of Industrial Property (INPI) and the European Patent Office databases, through the use of International Patent Classification and keywords and then categorized and analyzed. Brazilian authorship of articles about tuberculosis jumped from 1% in 1995 to 5% in 2010. Article production and patent filings of national origin have been concentrated in public universities and research institutions while the participation of private industry in the filing of Brazilian patents has remained limited. The goals of national patenting efforts have still not been reached, as up to the present none of the applications filed have been granted a patent. The analysis of all this data about TB publishing and patents clearly demonstrates the importance of maintaining the continuity of Brazil's production development policies as well as government support for infrastructure projects to be employed in transforming the potential of research. This policy, which already exists for the promotion of new products and processes that, in addition to bringing diverse economic benefits to the country, will also contribute to effective dealing with public health

  14. Enabling policy planning and innovation management through patent information and co-authorship network analyses: a study of tuberculosis in Brazil.

    Directory of Open Access Journals (Sweden)

    Alexandre Guimarães Vasconcellos

    Full Text Available INTRODUCTION: New tools and approaches are necessary to facilitate public policy planning and foster the management of innovation in countries' public health systems. To this end, an understanding of the integrated way in which the various actors who produce scientific knowledge and inventions in technological areas of interest operate, where they are located and how they relate to one another is of great relevance. Tuberculosis has been chosen as a model for the present study as it is a current challenge for Brazilian research and innovation. METHODOLOGY: Publications about tuberculosis written by Brazilian authors were accessed from international databases, analyzed, processed with text searching tools and networks of coauthors were constructed and visualized. Patent applications about tuberculosis in Brazil were retrieved from the Brazilian National Institute of Industrial Property (INPI and the European Patent Office databases, through the use of International Patent Classification and keywords and then categorized and analyzed. RESULTS/CONCLUSIONS: Brazilian authorship of articles about tuberculosis jumped from 1% in 1995 to 5% in 2010. Article production and patent filings of national origin have been concentrated in public universities and research institutions while the participation of private industry in the filing of Brazilian patents has remained limited. The goals of national patenting efforts have still not been reached, as up to the present none of the applications filed have been granted a patent. The analysis of all this data about TB publishing and patents clearly demonstrates the importance of maintaining the continuity of Brazil's production development policies as well as government support for infrastructure projects to be employed in transforming the potential of research. This policy, which already exists for the promotion of new products and processes that, in addition to bringing diverse economic benefits to the country

  15. Experimentalist governance

    NARCIS (Netherlands)

    Sabel, C.F.; Zeitlin, J.; Levi-Faur, D.

    2012-01-01

    A secular rise in volatility and uncertainty is overwhelming the capacities of conventional hierarchical governance and ‘command-and-control’ regulation in many settings. One significant response is the emergence of a novel, ‘experimentalist’ form of governance that establishes deliberately

  16. Interactive Governance

    DEFF Research Database (Denmark)

    Bang, Henrik

    2016-01-01

    and growth. However, interactive governance is not a property or effect of institutions; nor does it apply solely to those individuals who seek success above everything else. It is connective more than individualistic or collectivistic in nature; and it manifests a governability capacity which...

  17. Networking

    OpenAIRE

    Rauno Lindholm, Daniel; Boisen Devantier, Lykke; Nyborg, Karoline Lykke; Høgsbro, Andreas; Fries, de; Skovlund, Louise

    2016-01-01

    The purpose of this project was to examine what influencing factor that has had an impact on the presumed increasement of the use of networking among academics on the labour market and how it is expressed. On the basis of the influence from globalization on the labour market it can be concluded that the globalization has transformed the labour market into a market based on the organization of networks. In this new organization there is a greater emphasis on employees having social qualificati...

  18. What is the Relationship Between “Personality” and “Social” Psychologies? Network, Community, and Whole Text Analyses of The Structure of Contemporary Scholarship

    Directory of Open Access Journals (Sweden)

    Kevin Lanning

    2017-03-01

    Full Text Available The structure of social/personality psychology, including the relationship between the areas of “social” and “personality,” is empirically examined in a series of network, community, and text analyses. In a study of keywords, both attitudes and social cognition and group processes appear as communities; the role of personality is more diffuse. In a larger analysis of citations in the four primary journals in the combined social/personality area, personality appears as a large community which surrounds a well-defined core (the Five-Factor Model but which lies on the periphery of social/personality psychology. Interpersonal relations and attachment are central in social/personality, and appear largely distinct from the study of groups. Attitudes and social cognition are broadly studied, but, in contrast with personality and interpersonal relations, are not structured around a simple core. These methods and results collectively inform the relationship between personality and social psychologies and provide an early step towards an empirical understanding of the structure of the discipline.

  19. Renewing governance.

    Science.gov (United States)

    Loos, Gregory P

    2003-01-01

    Globalization's profound influence on social and political institutions need not be negative. Critics of globalization have often referred to the "Impossible Trinity" because decision-making must 1. respect national sovereignty, 2. develop and implement firm regulation, and 3. allow capital markets to be as free as possible. To many, such goals are mutually exclusive because history conditions us to view policy-making and governance in traditional molds. Thus, transnational governance merely appears impossible because current forms of governance were not designed to provide it. The world needs new tools for governing, and its citizens must seize the opportunity to help develop them. The rise of a global society requires a greater level of generality and inclusion than is found in most policy bodies today. Politicians need to re-examine key assumptions about government. States must develop ways to discharge their regulatory responsibilities across borders and collaborate with neighboring jurisdictions, multilateral bodies, and business. Concepts such as multilateralism and tripartism show great promise. Governments must engage civil society in the spirit of shared responsibility and democratic decision-making. Such changes will result in a renewal of the state's purpose and better use of international resources and expertise in governance.

  20. Regulatory Governance

    DEFF Research Database (Denmark)

    Kjær, Poul F.; Vetterlein, Antje

    2018-01-01

    , legal and cultural, on a global scale. Against this background, this special issue sets out to explore the multifaceted meaning, potential and impact as well as the social praxis of regulatory governance. Under the notions rules, resistance and responsibility the special issue pins out three overall......Regulatory governance frameworks have become essential building blocks of world society. From supply chains to the regimes surrounding international organizations, extensive governance frameworks have emerged which structure and channel a variety of social exchanges, including economic, political...

  1. Government Organizations

    DEFF Research Database (Denmark)

    Krause Hansen, Hans; Salskov-Iversen, Dorte

    2017-01-01

    This entry is concerned with demonstrating the increasingly important interface between government organization and communication. Government organization can be approached in terms of state centrism, where the emphasis is on government organization understood as state authority and power......, with clearly defined boundaries between the public and private; and in terms of polycentrism, where power and authority are seen as dispersed among state and nonstate organizations, including business and civil society organizations. Globalization and new media technologies imply changes in the relationship...... between power, communication, and organizational forms, and suggest the usefulness of viewing government organization in terms of polycentrism, highlighting communication and organizing processes in a wider perspective. The entry focuses particularly on two major strands of literature: deliberative...

  2. Who governs energy? The challenges facing global energy governance

    International Nuclear Information System (INIS)

    Florini, Ann; Sovacool, Benjamin K.

    2009-01-01

    This article conceptualizes the energy problems facing society from a global governance perspective. It argues that a notion of 'global energy governance,' taken to mean international collective action efforts undertaken to manage and distribute energy resources and provide energy services, offers a meaningful and useful framework for assessing energy-related challenges. The article begins by exploring the concepts of governance, global governance, and global energy governance. It then examines some of the existing institutions in place to establish and carry out rules and norms governing global energy problems and describes the range of institutional design options available to policymakers. It briefly traces the role of a selection of these institutions, from inter-governmental organizations to summit processes to multilateral development banks to global action networks, in responding to energy issues, and points out their strengths and weaknesses. The article concludes by analyzing how the various approaches to global governance differ in their applicability to addressing the conundrums of global energy problems.

  3. Organizational governance

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Klein, Peter G.

    This chapter reviews and discusses rational-choice approaches to organizational governance. These approaches are found primarily in organizational economics (virtually no rational-choice organizational sociology exists), particularly in transaction cost economics, principal-agent theory, and the ......This chapter reviews and discusses rational-choice approaches to organizational governance. These approaches are found primarily in organizational economics (virtually no rational-choice organizational sociology exists), particularly in transaction cost economics, principal-agent theory...

  4. Leadership, governance and knowledge in an enterprising place: the case of Brainport Eindhoven in the Netherlands.

    NARCIS (Netherlands)

    Horlings, L.G.

    2014-01-01

    Purpose This chapter addresses the question how entrepreneurial synergies can be stimulated in places by leadership and network governance in the context of the knowledge economy. The chapter not only analyses the role of leadership in a regional case in the Netherlands, but also assesses to what

  5. Is governance, gross domestic product, inequality, population size or country surface area associated with coverage and equity of health interventions? Ecological analyses of cross-sectional surveys from 80 countries.

    Science.gov (United States)

    Wehrmeister, Fernando C; da Silva, Inácio Crochemore M; Barros, Aluisio J D; Victora, Cesar G

    2017-01-01

    To assess associations between national characteristics, including governance indicators, with a proxy for universal health coverage in reproductive, maternal, newborn and child health (RMNCH). Ecological analysis based on data from national standardised cross-sectional surveys. Low-income and middle-income countries with a Demographic and Health Survey or a Multiple Indicator Cluster Survey since 2005. 1 246 710 mothers and 2 129 212 children from 80 national surveys. Gross domestic product (GDP), country surface area, population, Gini index and six governance indicators (control of corruption, political stability and absence of violence, government effectiveness, regulatory quality, rule of law, and voice and accountability). Levels and inequality in the composite coverage index (CCI), a weighted average of eight RMNCH interventions. Relative and absolute inequalities were measured through the concentration index (CIX) and slope index of inequality (SII) for CCI, respectively. The average values of CCI (70.5% (SD=13.3)), CIX (5.3 (SD=5.1)) and mean slope index (19.8 (SD=14.7)) were calculated. In the unadjusted analysis, all governance variables and GDP were positively associated with the CCI and negatively with inequalities. Country surface showed inverse associations with both inequality indices. After adjustment, among the governance indicators, only political stability and absence of violence was directly related to CCI (β=6.3; 95% CI 3.6 to 9.1; ppolitical stability and absence of violence, and with GDP, and inversely associated with country surface area.

  6. Sustainable transition of socio-technological systems: How can Governance Network Research and Transition Theory contribute to the transition to biofuel for transportation?

    DEFF Research Database (Denmark)

    Hansen, Ole Erik; Stærdahl, Jens; Søndergård, Bent

    The paper suggests that the challenge of sustainability demands a shift of the attention of environmental planning and policy to the transition of socio-technological systems. Deliberate planning for sustainability then becomes a question of addressing governance structures of socio-technological...... activities provides both a theoretical and empirical body of knowledge of such governance processes. The paper presents these approaches and demonstrates how they can be used in relation to the process of developing bio-fuel systems for transportation.......-technological systems, calling attention to how such governance structures emerge, stabilize and become dominant, which functions governance structures have to serve to become efficient, and how they can be made subject to deliberate and purposeful shaping and transition. Taking this approach, research in planning...

  7. Techniques for Analysing Problems in Engineering Projects

    DEFF Research Database (Denmark)

    Thorsteinsson, Uffe

    1998-01-01

    Description of how CPM network can be used for analysing complex problems in engineering projects.......Description of how CPM network can be used for analysing complex problems in engineering projects....

  8. Stakeholder Governance

    DEFF Research Database (Denmark)

    Flak, Leif Skiftenes; Rose, Jeremy

    2005-01-01

    The e-government field, like most young fields, lacks a strong body of well-developed theory. One strategy for coping with theoretical immaturity is to import and adapt theories from other, more mature fields. This study reviews Stakeholder Theory (ST) and investigates its potential in relation...... to e-Government. Originally a management theory, stakeholder theory advocates addressing the concerns of all stakeholders in a firm, as opposed to concentration on the interests of senior managers and stockholders. Apart from the original profit focus, there is no serious conceptual mismatch between...... stakeholder theory and government’s objective of providing policy and services for citizens and organizations – society’s stakeholders. Potential problems with adapting a management theory to a government setting are discussed. The paper further discusses how information technology impacts a stakeholder model...

  9. Government Regulatory

    Science.gov (United States)

    Becker, Katie

    Government regulation of food products, food processing, and food preparation is imperative in bringing an unadulterated, nonmisleading, and safe food product to market and is relevant to all areas of food science, including engineering, processing, chemistry, and microbiology. The liability associated with providing consumers with an adulterated or substandard product cannot only tarnish a company's name and reputation, but also impose substantial financial repercussions on the company and those individuals who play an active role in the violation. In order for a company to fully comply with the relevant food laws (both federal and state), an intimate knowledge of food science is required. Individuals knowledgeable in food science play an integral role not only in implementing and counseling food companies/processors to ensure compliance with government regulations, but these individuals are also necessary to the state and federal governments that make and enforce the relevant laws and regulators.

  10. Analyses of the response of a complex weighted network to nodes removal strategies considering links weight: The case of the Beijing urban road system

    Science.gov (United States)

    Bellingeri, Michele; Lu, Zhe-Ming; Cassi, Davide; Scotognella, Francesco

    2018-02-01

    Complex network response to node loss is a central question in different fields of science ranging from physics, sociology, biology to ecology. Previous studies considered binary networks where the weight of the links is not accounted for. However, in real-world networks the weights of connections can be widely different. Here, we analyzed the response of real-world road traffic complex network of Beijing, the most prosperous city in China. We produced nodes removal attack simulations using classic binary node features and we introduced weighted ranks for node importance. We measured the network functioning during nodes removal with three different parameters: the size of the largest connected cluster (LCC), the binary network efficiency (Bin EFF) and the weighted network efficiency (Weg EFF). We find that removing nodes according to weighted rank, i.e. considering the weight of the links as a number of taxi flows along the roads, produced in general the highest damage in the system. Our results show that: (i) in order to model Beijing road complex networks response to nodes (intersections) failure, it is necessary to consider the weight of the links; (ii) to discover the best attack strategy, it is important to use nodes rank accounting links weight.

  11. Mobilizing Government

    DEFF Research Database (Denmark)

    Wang, Cancan; Medaglia, Rony; Jensen, Tina Blegind

    2016-01-01

    The nature of inter-organizational collaboration between government and other stakeholders is rapidly changing with the introduction of open social media (OSM) platforms. Characterized by a high degree of informality as well as a blurred personal/professional nature, OSM can potentially introduce...... changes and tensions in the well-established routines of the public sector. This paper aims at shedding light on such changes, presenting findings from a study on the use of an OSM platform, WeChat, in an interorganizational collaboration project between government, university, and industry stakeholders...... rather than on organizational affiliation; and a transition from formal to informal as well as from professional to private collaboration....

  12. Geodetic Control Points, Chippewa County has been working on tightening up their control network over the years. The first network was constructed in 1993, with densification done from 2008-2011., Published in 2011, Not Applicable scale, Chippewa County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Geodetic Control Points dataset current as of 2011. Chippewa County has been working on tightening up their control network over the years. The first network was...

  13. Good government and good governance: record keeping in a ...

    African Journals Online (AJOL)

    This article addresses the challenges that arise when record keeping systems are advocated as a necessary under-pinning for good government and good governance. The relationship between record keeping and accountability is analysed and contextualised in relation to transparency and Freedom of Information ...

  14. Network cosmology.

    Science.gov (United States)

    Krioukov, Dmitri; Kitsak, Maksim; Sinkovits, Robert S; Rideout, David; Meyer, David; Boguñá, Marián

    2012-01-01

    Prediction and control of the dynamics of complex networks is a central problem in network science. Structural and dynamical similarities of different real networks suggest that some universal laws might accurately describe the dynamics of these networks, albeit the nature and common origin of such laws remain elusive. Here we show that the causal network representing the large-scale structure of spacetime in our accelerating universe is a power-law graph with strong clustering, similar to many complex networks such as the Internet, social, or biological networks. We prove that this structural similarity is a consequence of the asymptotic equivalence between the large-scale growth dynamics of complex networks and causal networks. This equivalence suggests that unexpectedly similar laws govern the dynamics of complex networks and spacetime in the universe, with implications to network science and cosmology.

  15. Electronic Government

    DEFF Research Database (Denmark)

    Wimmer, Maria A.; Traunmüller, Roland; Grönlund, Åke

    This book constitutes the refereed proceedings of the 4th International Conference on Electronic Government, EGOV 2005, held in Copenhagen, Denmark, in August 2005. The 30 revised papers presented were carefully reviewed and selected from numerous submissions, and assess the state-of-the-art in e...

  16. Bank Governance

    OpenAIRE

    Laura Ard; Alexander Berg

    2010-01-01

    Principles of good governance have been a major component of international financial standards and are seen as essential to the stability and integrity of financial systems. Over the past 10 years much energy and attention have gone to improving the ability of company boards, managers, and owners to prudently navigate rapidly changing and volatile market conditions. So, how to explain the ...

  17. Governing principles.

    Science.gov (United States)

    Cook, Andrew

    2003-12-01

    BUPA HOSPITALS LIMITED took an early stand at a corporate level by championing the value of clinical governance for independent hospitals. The challenge this presented was never underestimated but was seen as a means to improve quality, patient outcomes and accountability, and ultimately to create a firm platform for the delivery of business objectives.

  18. Acoustofluidics 1: Governing equations in microfluidics

    DEFF Research Database (Denmark)

    Bruus, Henrik

    2011-01-01

    Governing equations for microfluidics and basic flow solutions are presented. Equivalent circuit modeling for determining flow rates in microfluidic networks is introduced.......Governing equations for microfluidics and basic flow solutions are presented. Equivalent circuit modeling for determining flow rates in microfluidic networks is introduced....

  19. Governing EU employment policy

    DEFF Research Database (Denmark)

    Sørensen, Eva; Triantafillou, Peter; Damgaard, Bodil

    2015-01-01

    In the European Union (EU), employment policy is a prerogative of the member states. Therefore the EU's ability to govern in this area depends on its capability to involve national governments and relevant stakeholders in a collaborative effort to formulate and implement shared policy objectives....... Drawing an analytical distinction between cooperation, coordination and collaboration, the article analyses the formulation and implementation of EU employment policies. It concludes that while the formulation of policy objectives and the discussion of national policy approaches do involve elements...... of collaboration, the implementation phase mainly consists in the less demanding forms of cooperation and coordination....

  20. Proceedings of the Government Neural Network Applications Workshop Held at Wright-Patterson AFB, Ohio on August 24-26, 1992. Volume 1

    Science.gov (United States)

    1992-08-01

    the case in (2). The Hodgkin - Huxley equation thus provides the crucial insight for the electronic circuit designers that models of neural networks can...Neural Network Architecture for Discriminating Tone-Varying 3 Undeiwer Signals D. J. Adams, S. Clary - Loral Defense Systems, Akron; Y .-H. Pao, T.L...Self-Oscillators Y . A. Saet 1 Design and Implementation of the ACU: An Expandable ANN Building Block R. J. Schalkoff, K.F. Poole, R.E. Owens, J.N

  1. Governance and Institutional Autonomy: Governing and Governance in Portuguese Higher Education

    Science.gov (United States)

    Magalhaes, Antonio; Veiga, Amelia; Ribeiro, Filipa; Amaral, Alberto

    2013-01-01

    This paper aims at looking at governance instruments beyond managerial technicality. It intends to do so by analysing the impact of governance reforms on the universities autonomy assumed as a regulation instrument to politically steer systems and institutions. The regulation efforts undertaken at the European and national levels reflect a trend…

  2. Multi-level Governance as an Alternative: The Municipality of Barcelona and the Ciutat Refugi Plan

    Directory of Open Access Journals (Sweden)

    Ezgi Irgil

    2016-12-01

    Full Text Available This paper analyses the response of the Municipality of Barcelona to the Syrian refugee crisis in Europe as an alternative solution that challenges the national government’s restrictive approach. This response introduces the Ciutat Refugi Plan with a city-to-city network at the municipal level that involves other European cities in creating safe routes for refugees at the local government level. In line with multi-level governance theory, I argue that central governments’ inaction has pressured local governments to take action during the Syrian refugee influx. Relying on the influence of local government networks, the Municipality of Barcelona uses discourse as a tool of action in opening discursive spaces for humanitarian political responses to the refugee crisis. Using critical discourse analysis, I test this argument by examining in-depth interviews, speeches of people in power that have appeared in news articles, and statements on official websites.

  3. Cloud Governance

    DEFF Research Database (Denmark)

    Berthing, Hans Henrik

    Denne præsentation beskriver fordele og værdier ved anvendelse af Cloud Computing. Endvidere inddrager resultater fra en række internationale analyser fra ISACA om Cloud Computing.......Denne præsentation beskriver fordele og værdier ved anvendelse af Cloud Computing. Endvidere inddrager resultater fra en række internationale analyser fra ISACA om Cloud Computing....

  4. System-level insights into the cellular interactome of a non-model organism: inferring, modelling and analysing functional gene network of soybean (Glycine max.

    Directory of Open Access Journals (Sweden)

    Yungang Xu

    Full Text Available Cellular interactome, in which genes and/or their products interact on several levels, forming transcriptional regulatory-, protein interaction-, metabolic-, signal transduction networks, etc., has attracted decades of research focuses. However, such a specific type of network alone can hardly explain the various interactive activities among genes. These networks characterize different interaction relationships, implying their unique intrinsic properties and defects, and covering different slices of biological information. Functional gene network (FGN, a consolidated interaction network that models fuzzy and more generalized notion of gene-gene relations, have been proposed to combine heterogeneous networks with the goal of identifying functional modules supported by multiple interaction types. There are yet no successful precedents of FGNs on sparsely studied non-model organisms, such as soybean (Glycine max, due to the absence of sufficient heterogeneous interaction data. We present an alternative solution for inferring the FGNs of soybean (SoyFGNs, in a pioneering study on the soybean interactome, which is also applicable to other organisms. SoyFGNs exhibit the typical characteristics of biological networks: scale-free, small-world architecture and modularization. Verified by co-expression and KEGG pathways, SoyFGNs are more extensive and accurate than an orthology network derived from Arabidopsis. As a case study, network-guided disease-resistance gene discovery indicates that SoyFGNs can provide system-level studies on gene functions and interactions. This work suggests that inferring and modelling the interactome of a non-model plant are feasible. It will speed up the discovery and definition of the functions and interactions of other genes that control important functions, such as nitrogen fixation and protein or lipid synthesis. The efforts of the study are the basis of our further comprehensive studies on the soybean functional

  5. Project governance: "Schools of thought"

    Directory of Open Access Journals (Sweden)

    Michiel Christiaan Bekker

    2014-02-01

    Full Text Available The terminology, definition and context of project governance have become a focal subject for research and discussions in project management literature. This article reviews literature on the subject of project governance and categorise the arguments into three schools of thought namely the single-firm school, multi-firm school and large capital school. The single-firm school is concerned with governance principles related to internal organisational projects and practice these principles at a technical level. The multi-firm school address the governance principles concerned with two of more organisations participating on a contractual basis on the same project and focus their governance efforts at the technical and strategic level. The large capital school consider projects as temporary organisations, forming their own entity and establishing governance principles at an institutional level. From these schools of thought it can be concluded that the definition of project governance is dependent on the type of project and hierarchical positioning in the organisation. It is also evident that further research is required to incorporate other governance variables and mechanisms such as transaction theory, social networks and agency theory. The development of project governance frameworks should also consider the complexity of projects spanning across international companies, across country borders and incorporating different value systems, legal systems, corporate governance guidelines, religions and business practices.

  6. Hydraulic properties of fracture networks; Analyse des proprietes hydrauliques des reseaux de fractures: discussion des modeles d'ecoulement compatibles avec les principales proprietes geometriques

    Energy Technology Data Exchange (ETDEWEB)

    Dreuzy, J.R. de

    1999-12-15

    Fractured medium are studied in the general framework of oil and water supply and more recently for the underground storage of high level nuclear wastes. As fractures are generally far more permeable than the embedding medium, flow is highly channeled in a complex network of fractures. The complexity of the network comes from the broad distributions of fracture length and permeability at the fracture scale and appears through the increase of the equivalent permeability at the network scale. The goal of this thesis is to develop models of fracture networks consistent with both local-scale and global-scale observations. Bidimensional models of fracture networks display a wide variety of flow structures ranging from the sole permeable fracture to the equivalent homogeneous medium. The type of the relevant structure depends not only on the density and the length and aperture distributions but also on the observation scale. In several models, a crossover scale separates complex structures highly channeled from more distributed and homogeneous-like flow patterns at larger scales. These models, built on local characteristics and validated by global properties, have been settled in steady state. They have also been compared to natural well test data obtained in Ploemeur (Morbihan) in transient state. The good agreement between models and data reinforces the relevance of the models. Once validated and calibrated, the models are used to estimate the global tendencies of the main flow properties and the risk associated with the relative lack of data on natural fractures media. (author)

  7. Implementing statistical learning methods through Bayesian networks (Part 2): Bayesian evaluations for results of black toner analyses in forensic document examination.

    Science.gov (United States)

    Biedermann, A; Taroni, F; Bozza, S; Mazzella, W D

    2011-01-30

    This paper presents and discusses the use of Bayesian procedures - introduced through the use of Bayesian networks in Part I of this series of papers - for 'learning' probabilities from data. The discussion will relate to a set of real data on characteristics of black toners commonly used in printing and copying devices. Particular attention is drawn to the incorporation of the proposed procedures as an integral part in probabilistic inference schemes (notably in the form of Bayesian networks) that are intended to address uncertainties related to particular propositions of interest (e.g., whether or not a sample originates from a particular source). The conceptual tenets of the proposed methodologies are presented along with aspects of their practical implementation using currently available Bayesian network software. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  8. Contesting Citizenship: Comparative Analyses

    DEFF Research Database (Denmark)

    Siim, Birte; Squires, Judith

    2007-01-01

    importance of particularized experiences and multiple ineequality agendas). These developments shape the way citizenship is both practiced and analysed. Mapping neat citizenship modles onto distinct nation-states and evaluating these in relation to formal equality is no longer an adequate approach....... Comparative citizenship analyses need to be considered in relation to multipleinequalities and their intersections and to multiple governance and trans-national organisinf. This, in turn, suggests that comparative citizenship analysis needs to consider new spaces in which struggles for equal citizenship occur...

  9. Governing Warfare

    DEFF Research Database (Denmark)

    Harste, Gorm

      It would seem as though warfare has gotten out of control, not only in Iraq and Afghanistan, but also in Central Africa. The paper outlines the strategic history of politically controlled warfare since the early Enlightenment. The argument is that control is implausible. The idea of control has...... the risks of lacking unity and displays the organisational trap to the fatal political myth of controlled warfare: Does it come from the military organisation system itself, from political ideologies of goal-rational governance, or from the chameleonic logic of wars?  ...

  10. Social Network Analyses (SNA) as a method to study the structure of contacts within teams of a school for secondary education

    NARCIS (Netherlands)

    Meijs, Celeste; De Laat, Maarten

    2017-01-01

    This paper reports findings from a study using social network analysis techniques to understand social learning relationships within and between teacher teams in a large secondary school in the Netherlands (n=117 teachers). The findings suggest a relationship between the social structure of a team

  11. Are Student Evaluations of Teaching Effectiveness Valid for Measuring Student Learning Outcomes in Business Related Classes? A Neural Network and Bayesian Analyses

    Science.gov (United States)

    Galbraith, Craig S.; Merrill, Gregory B.; Kline, Doug M.

    2012-01-01

    In this study we investigate the underlying relational structure between student evaluations of teaching effectiveness (SETEs) and achievement of student learning outcomes in 116 business related courses. Utilizing traditional statistical techniques, a neural network analysis and a Bayesian data reduction and classification algorithm, we find…

  12. Urban Governance of Disease

    Directory of Open Access Journals (Sweden)

    Julie E. Fischer

    2012-04-01

    Full Text Available Rapid population growth, urbanization, and the growing challenges faced by the urban poor require redefining the paradigm for public health interventions in the 21st century, creating new approaches that take urban determinants of health into consideration. The widening disparity between the urban poor and the urban rich further exacerbates health inequities. Existing tools for global governance of urban health risks fall short, particularly in the lack of formal mechanisms to strengthen collaboration and communication among national and municipal agencies and between their local and international non-governmental partners. There is also a clear disconnect between governance strategies crafted at the international level and implementation on the ground. The challenge is to find common ground for global goods and municipal needs, and to craft innovative and dynamic policy solutions that can benefit some of the poorest citizens of the global urban network.

  13. Imperial Governance

    DEFF Research Database (Denmark)

    Gravier, Magali

    2015-01-01

    of this concept, which is ‘tailored’ to analyse only one type of empire, the colonial empire, and to disregard the existence of another type of empire. To escape this trap, the article suggests the use of two concepts, ‘inwards imperial governance’ and ‘outwards imperial governance’. These concepts make...

  14. Redes como perspectiva de análise e como estrutura de governança: uma análise das diferentes contribuições Networks as an analysis perspective and as a governance structure: an analysis of different contributions

    Directory of Open Access Journals (Sweden)

    Fernando dias Lopes

    2009-10-01

    Full Text Available Este artigo discute as abordagens de redes nas suas diferentes dimensões, mostrando como elas vêm sendo desenvolvidas, suas distinções e inter-relações. As redes como estrutura de governança e como perspectiva de análise não devem ser excludentes, mas sim dimensões que precisam ser utilizadas de forma integrada. Serão abordadas ainda suas contribuições para análise de fenômenos sociais, suas diferentes formas, limitações e perspectivas teóricas utilizadas para explicar sua formação.This article reviews network approaches in their different dimensions, how these approaches have been developed and, their distinctions and inter-relations. Network as a governance structure and as an analysis perspective should not have taken as excluding, but as dimensions that need to be grasped in an integrated framework. This article emphasizes their contributions for the analyses of social phenomena, their different forms, limitations, as well as the theoretical perspectives that explain their formation.

  15. Governing Engineering

    DEFF Research Database (Denmark)

    Buch, Anders

    2012-01-01

    Most people agree that our world face daunting problems and, correctly or not, technological solutions are seen as an integral part of an overall solution. But what exactly are the problems and how does the engineering ‘mind set’ frame these problems? This chapter sets out to unravel dominant...... perspectives in challenge per-ception in engineering in the US and Denmark. Challenge perception and response strategies are closely linked through discursive practices. Challenge perceptions within the engineering community and the surrounding society are thus critical for the shaping of engineering education...... and the engineering profession. Through an analysis of influential reports and position papers on engineering and engineering education the chapter sets out to identify how engineering is problematized and eventually governed. Drawing on insights from governmentality studies the chapter strives to elicit the bodies...

  16. Governing Engineering

    DEFF Research Database (Denmark)

    Buch, Anders

    2011-01-01

    Abstract: Most people agree that our world faces daunting problems and, correctly or not, technological solutions are seen as an integral part of an overall solution. But what exactly are the problems and how does the engineering ‘mind set’ frame these problems? This chapter sets out to unravel...... dominant perspectives in challenge perception in engineering in the US and Denmark. Challenge perception and response strategies are closely linked through discursive practices. Challenge perceptions within the engineering community and the surrounding society are thus critical for the shaping...... of engineering education and the engineering profession. Through an analysis of influential reports and position papers on engineering and engineering education the chapter sets out to identify how engineering is problematized and eventually governed. Drawing on insights from governmentality studies the chapter...

  17. Understanding Strategic Information Manoeuvres in Network Media to Advance Cyber Operations: A Case Study Analysing Pro-Russian Separatists’ Cyber Information Operations in Crimean Water Crisis

    Directory of Open Access Journals (Sweden)

    Al-Khateeb Samer

    2016-06-01

    Full Text Available The inexpensive nature and wide availability of emerging media outlets, e.g. social networking sites and blogs makes them easy-to-use weapons, giving power and courage to individuals to form groups that are able to win or at least force concessions from stronger forces. Today, terrorist groups know that opinions can be influenced using networked media and this knowledge empowers and enables them to alienate their audience and sometimes provoke them into violent actions. To understand the strategic information manoeuvres used by such groups, e.g., trans-national terrorist groups, we study the channels (blogs, Twitter, etc. and methods (e.g., influential actors/groups they use to disseminate messages pertaining to recruitment, radicalization, and raising funds. We collect data from several sources, including over 130 blog websites known for pro-Russian propaganda for events such as the Crimean water crisis and Trident Juncture Exercise (TRJE 15. In addition to blogs, we collect data from Twitter for the above-mentioned events to study the crossinfluence of various social media platforms in conducting strategic information manoeuvres. The study shows that groups are able to spread their opinions and create emotional attitudes for their followers through the sophisticated and blended use of these network media platforms via powerful actors, trolls, and botnets. We design social and network science informed methodologies to study the sociotechnical behaviours of trolls and botnets and develop detection tools ready to be deployed for Cyber operations. The tools have been further tested in the information operations of ISIL, e.g., beheading of hostages in orange jump suits. This study helps identifying the actions needed to win this “battle of ideas”.

  18. Analysing applicant's attraction with social networks on both sides of the table: those who recruit and those who are recruited have a compatible performance?

    Directory of Open Access Journals (Sweden)

    Daniel Roque Gomes

    2016-12-01

    Full Text Available Applicant’s attraction in recruitment is perhaps one of the best known areas that integrate knowledge from different fields of research, such as the HRM, Communication and Work and Organizational Psychology. Under this thematic, the social networks (SN began to be understood as useful for recruitment purposes. The main objective of this research is to describe and understand the compatibility between the practices of recruiters regarding applicant’s attraction using SN and the expectations of the latter ones when looking for jobs via SN. This work has allowed us to generate a set of considerations regarding the theoretical, empirical and practical levels.

  19. Scaling in public transport networks

    Directory of Open Access Journals (Sweden)

    C. von Ferber

    2005-01-01

    Full Text Available We analyse the statistical properties of public transport networks. These networks are defined by a set of public transport routes (bus lines and the stations serviced by these. For larger networks these appear to possess a scale-free structure, as it is demonstrated e.g. by the Zipf law distribution of the number of routes servicing a given station or for the distribution of the number of stations which can be visited from a chosen one without changing the means of transport. Moreover, a rather particular feature of the public transport network is that many routes service common subsets of stations. We discuss the possibility of new scaling laws that govern intrinsic properties of such subsets.

  20. Condition based maintenance of a 20 kV-PE/XLPE-insulated cable network using the IRC-Analysis; Zustandsorientierte Instandhaltung eines polymerisolierten 20-kV-Kabelnetzes mit der IRC-Analyse. Moderne Diagnostik reduziert Stoerungsrate

    Energy Technology Data Exchange (ETDEWEB)

    Hoff, G.; Kranz, H.G. [BUGH Wuppertal (Germany). Labs. fuer Hochspannungstechnik; Beigert, M.; Petzold, F. [Seba Dynatronic Mess- und Ortungstechnik GmbH, Baunach (Germany); Kneissl, C. [Bereich Konzeption und Messtechnik, Lech Elektrizitaetswerke AG, Augsburg (Germany)

    2001-10-22

    For a preventive maintenance of a polymer insulated cable network a destruction free estimation of the status of the buried PE/XLPE-cables is needed. This contribution presents a condition based maintenance concept which is based on the IRC-Analysis. With this concept a major German utility was able to reduce the amount of failures in a part of the 20kV-cable network. The general tendency of increasing faults was broken. (orig.) [German] Die praeventive Instandhaltung in polymerisolierten Kabelnetzen setzt eine zerstoerungsfreie Zustandbestimmung von gelegten PE/VPE-isolierten Kabeln voraus. Die-Verfasser beschreiben ein zustandsorientiertes Wartungskonzept auf Basis der IRC-Analyse, mit dem es gelungen ist, in einem Teil des 20-kV-Kabelnetzes eines Energieversorgers die in der Vergangenheit stetig steigende Stoerungsrate drastisch zu reduzieren. (orig.)

  1. E-government transformations: Challenges and strategies

    DEFF Research Database (Denmark)

    Pedersen, Keld

    2018-01-01

    The purpose of this research is to investigate how we can analyse the possibilities for e-government transformations in public sector organisations and how these possibilities can be improved.......The purpose of this research is to investigate how we can analyse the possibilities for e-government transformations in public sector organisations and how these possibilities can be improved....

  2. Neural network modeling and geochemical water analyses to understand and forecast karst and non-karst part of flash floods (case study on the Lez river, Southern France)

    Science.gov (United States)

    Darras, T.; Raynaud, F.; Borrell Estupina, V.; Kong-A-Siou, L.; Van-Exter, S.; Vayssade, B.; Johannet, A.; Pistre, S.

    2015-06-01

    Flash floods forecasting in the Mediterranean area is a major economic and societal issue. Specifically, considering karst basins, heterogeneous structure and nonlinear behaviour make the flash flood forecasting very difficult. In this context, this work proposes a methodology to estimate the contribution from karst and non-karst components using toolbox including neural networks and various hydrological methods. The chosen case study is the flash flooding of the Lez river, known for his complex behaviour and huge stakes, at the gauge station of Lavallette, upstream of Montpellier (400 000 inhabitants). After application of the proposed methodology, discharge at the station of Lavallette is spited between hydrographs of karst flood and surface runoff, for the two events of 2014. Generalizing the method to future events will allow designing forecasting models specifically for karst and surface flood increasing by this way the reliability of the forecasts.

  3. Neural network modeling and geochemical water analyses to understand and forecast karst and non-karst part of flash floods (case study on the Lez river, Southern France

    Directory of Open Access Journals (Sweden)

    T. Darras

    2015-06-01

    Full Text Available Flash floods forecasting in the Mediterranean area is a major economic and societal issue. Specifically, considering karst basins, heterogeneous structure and nonlinear behaviour make the flash flood forecasting very difficult. In this context, this work proposes a methodology to estimate the contribution from karst and non-karst components using toolbox including neural networks and various hydrological methods. The chosen case study is the flash flooding of the Lez river, known for his complex behaviour and huge stakes, at the gauge station of Lavallette, upstream of Montpellier (400 000 inhabitants. After application of the proposed methodology, discharge at the station of Lavallette is spited between hydrographs of karst flood and surface runoff, for the two events of 2014. Generalizing the method to future events will allow designing forecasting models specifically for karst and surface flood increasing by this way the reliability of the forecasts.

  4. Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease.

    Science.gov (United States)

    Lin, Biaoyang; White, James T; Lu, Wei; Xie, Tao; Utleg, Angelita G; Yan, Xiaowei; Yi, Eugene C; Shannon, Paul; Khrebtukova, Irina; Lange, Paul H; Goodlett, David R; Zhou, Daixing; Vasicek, Thomas J; Hood, Leroy

    2005-04-15

    Prostate cancer is initially responsive to androgen ablation therapy and progresses to androgen-unresponsive states that are refractory to treatment. The mechanism of this transition is unknown. A systems approach to disease begins with the quantitative delineation of the informational elements (mRNAs and proteins) in various disease states. We employed two recently developed high-throughput technologies, massively parallel signature sequencing (MPSS) and isotope-coded affinity tag, to gain a comprehensive picture of the changes in mRNA levels and more restricted analysis of protein levels, respectively, during the transition from androgen-dependent LNCaP (model for early-stage prostate cancer) to androgen-independent CL1 cells (model for late-stage prostate cancer). We sequenced >5 million MPSS signatures, obtained >142,000 tandem mass spectra, and built comprehensive MPSS and proteomic databases. The integrated mRNA and protein expression data revealed underlying functional differences between androgen-dependent and androgen-independent prostate cancer cells. The high sensitivity of MPSS enabled us to identify virtually all of the expressed transcripts and to quantify the changes in gene expression between these two cell states, including functionally important low-abundance mRNAs, such as those encoding transcription factors and signal transduction molecules. These data enable us to map the differences onto extant physiologic networks, creating perturbation networks that reflect prostate cancer progression. We found 37 BioCarta and 14 Kyoto Encyclopedia of Genes and Genomes pathways that are up-regulated and 23 BioCarta and 22 Kyoto Encyclopedia of Genes and Genomes pathways that are down-regulated in LNCaP cells versus CL1 cells. Our efforts represent a significant step toward a systems approach to understanding prostate cancer progression.

  5. Early transcriptome analyses of Z-3-Hexenol-treated zea mays revealed distinct transcriptional networks and anti-herbivore defense potential of green leaf volatiles.

    Directory of Open Access Journals (Sweden)

    Jurgen Engelberth

    Full Text Available Green leaf volatiles (GLV, which are rapidly emitted by plants in response to insect herbivore damage, are now established as volatile defense signals. Receiving plants utilize these molecules to prime their defenses and respond faster and stronger when actually attacked. To further characterize the biological activity of these compounds we performed a microarray analysis of global gene expression. The focus of this project was to identify early transcriptional events elicited by Z-3-hexenol (Z-3-HOL as our model GLV in maize (Zea mays seedlings. The microarray results confirmed previous studies on Z-3-HOL -induced gene expression but also provided novel information about the complexity of Z-3-HOL -induced transcriptional networks. Besides identifying a distinct set of genes involved in direct and indirect defenses we also found significant expression of genes involved in transcriptional regulation, Ca(2+-and lipid-related signaling, and cell wall reinforcement. By comparing these results with those obtained by treatment of maize seedlings with insect elicitors we found a high degree of correlation between the two expression profiles at this early time point, in particular for those genes related to defense. We further analyzed defense gene expression induced by other volatile defense signals and found Z-3-HOL to be significantly more active than methyl jasmonate, methyl salicylate, and ethylene. The data presented herein provides important information on early genetic networks that are activated by Z-3-HOL and demonstrates the effectiveness of this compound in the regulation of typical plant defenses against insect herbivores in maize.

  6. Open Government Data in Russian Federation

    OpenAIRE

    Koznov, Dmitrij; Andreeva, Olga; Nikula, Uolevi; Maglyas, Andrey; Muromtsev, Dmitry; Radchenko, Irina

    2016-01-01

    Open data can increase transparency and accountability of a country government, leading to free information sharing and stimulation of new innovations. This paper analyses government open data policy as well as open data initiatives and trends in Russian Federation. The OCDE analytical framework for national open government data portals and supporting initiatives is used as the bases for the study. The key issues of Russian open government data movement are summarized and aggregated. The pape...

  7. Who governs energy? The challenges facing global energy governance

    Energy Technology Data Exchange (ETDEWEB)

    Florini, Ann; Sovacool, Benjamin K. [Centre on Asia and Globalisation, Lee Kuan Yew School of Public Policy, National University of Singapore, Singapore 259772 (Singapore)

    2009-12-15

    This article conceptualizes the energy problems facing society from a global governance perspective. It argues that a notion of 'global energy governance,' taken to mean international collective action efforts undertaken to manage and distribute energy resources and provide energy services, offers a meaningful and useful framework for assessing energy-related challenges. The article begins by exploring the concepts of governance, global governance, and global energy governance. It then examines some of the existing institutions in place to establish and carry out rules and norms governing global energy problems and describes the range of institutional design options available to policymakers. It briefly traces the role of a selection of these institutions, from inter-governmental organizations to summit processes to multilateral development banks to global action networks, in responding to energy issues, and points out their strengths and weaknesses. The article concludes by analyzing how the various approaches to global governance differ in their applicability to addressing the conundrums of global energy problems. (author)

  8. World governance for energy

    International Nuclear Information System (INIS)

    Kerebel, C.; Keppler, J.H.

    2009-01-01

    As energy is a strategic stake for industrial societies through supply security, economical competitiveness and environmental performance, it is well-founded and useful to consider the way that energy production and consumption are organized. This document introduces the notion of energy governance and its different interpretations, then analyses its stakes and challenges (petroleum, natural gas, investment needs), and discusses some of the debates already in progress, such as the UNO's negotiations on greenhouse gas emission reduction or the impact of the WTO talks on energy exchanges

  9. U.S. Government Activities to Protect the Information Infrastructure

    National Research Council Canada - National Science Library

    Steinauer, Dennis

    1998-01-01

    .... Over the past few years, U.S. Government organizations have expanded their use of computer networks to conduct business, deliver services, and share information with industry, other government organizations, and the public...

  10. Tree agency and urban forest governance

    DEFF Research Database (Denmark)

    Konijnendijk, Cecil Cornelis

    2016-01-01

    Purpose – The role of urban forests and urban trees in creating vibrant and resilient cities is widely recognised. Urban forest governance as the strategic decision and rule making for urban tree resources is no longer solely the domain of governmental actors, but occurs rather often as network...... governance also involving businesses and civic society. However, governance theory usually does not consider the role of non-human agency, which can be considered problematic due to, for example, the important role of urban trees in place making. The purpose of this paper is to provide further insight...... into the importance of considering tree agency in governance. Design/methodology/approach – Taking an environmental governance and actor network theory perspective, the paper presents a critical view of current urban forest governance, extending the perspective to include not only a wide range of human actors...

  11. Government Services Information Infrastructure Management

    Energy Technology Data Exchange (ETDEWEB)

    Cavallini, J.S.; Aiken, R.J.

    1995-04-01

    The Government Services Information Infrastructure (GSII) is that portion of the NII used to link Government and its services, enables virtual agency concepts, protects privacy, and supports emergency preparedness needs. The GSII is comprised of the supporting telecommunications technologies, network and information services infrastructure and the applications that use these. The GSII is an enlightened attempt by the Clinton/Gore Administration to form a virtual government crossing agency boundaries to interoperate more closely with industry and with the public to greatly improve the delivery of government services. The GSII and other private sector efforts, will have a significant impact on the design, development, and deployment of the NII, even if only through the procurement of such services. The Federal Government must adopt new mechanisms and new paradigms for the management of the GSII, including improved acquisition and operation of GSII components in order to maximize benefits. Government requirements and applications will continue to evolv. The requirements from government services and users of form affinity groups that more accurately and effectively define these common requirements, that drive the adoption and use of industry standards, and that provide a significant technology marketplace.

  12. PecS is an important player in the regulatory network governing the coordinated expression of virulence genes during the interaction between Dickeya dadantii 3937 and plants.

    Science.gov (United States)

    Mhedbi-Hajri, Nadia; Malfatti, Pierrette; Pédron, Jacques; Gaubert, Stéphane; Reverchon, Sylvie; Van Gijsegem, Frédérique

    2011-11-01

    Successful infection of a pathogen relies on the coordinated expression of numerous virulence factor-encoding genes. In plant-bacteria interactions, this control is very often achieved through the integration of several regulatory circuits controlling cell-cell communication or sensing environmental conditions. Dickeya dadantii (formerly Erwinia chrysanthemi), the causal agent of soft rot on many crops and ornamentals, provokes maceration of infected plants mainly by producing and secreting a battery of plant cell wall-degrading enzymes. However, several other virulence factors have also been characterized. During Arabidopsis infection, most D. dadantii virulence gene transcripts accumulated in a coordinated manner during infection. This activation requires a functional GacA-GacS two-component regulatory system but the Gac system is not involved in the growth phase dependence of virulence gene expression. Here we show that, contrary to Pectobacterium, the AHL-mediated ExpIR quorum-sensing system does not play a major role in the growth phase-dependent control of D. dadantii virulence genes. On the other hand, the global regulator PecS participates in this coordinated expression since, in a pecS mutant, an early activation of virulence genes is observed both in vitro and in planta. This correlated with the known hypervirulence phenotype of the pecS mutant. Analysis of the relationship between the regulatory circuits governed by the PecS and GacA global regulators indicates that these two regulators act independently. PecS prevents a premature expression of virulence genes in the first stages of colonization whereas GacA, presumably in conjunction with other regulators, is required for the activation of virulence genes at the onset of symptom occurrence. © 2011 Society for Applied Microbiology and Blackwell Publishing Ltd.

  13. HFR1 Sequesters PIF1 to Govern the Transcriptional Network Underlying Light-Initiated Seed Germination in Arabidopsis[C][W][OPEN

    Science.gov (United States)

    Shi, Hui; Zhong, Shangwei; Mo, Xiaorong; Liu, Na; Nezames, Cynthia D.; Deng, Xing Wang

    2013-01-01

    Seed germination is the first step for seed plants to initiate a new life cycle. Light plays a predominant role in promoting seed germination, where the initial phase is mediated by photoreceptor phytochrome B (phyB). Previous studies showed that PHYTOCHROME-INTERACTING FACTOR1 (PIF1) represses seed germination downstream of phyB. Here, we identify a positive regulator of phyB-dependent seed germination, LONG HYPOCOTYL IN FAR-RED1 (HFR1). HFR1 blocks PIF1 transcriptional activity by forming a heterodimer with PIF1 that prevents PIF1 from binding to DNA. Our whole-genomic analysis shows that HFR1 and PIF1 oppositely mediate the light-regulated transcriptome in imbibed seeds. Through the HFR1–PIF1 module, light regulates expression of numerous genes involved in cell wall loosening, cell division, and hormone pathways to initiate seed germination. The functionally antagonistic HFR1–PIF1 pair constructs a fail-safe mechanism for fine-tuning seed germination during low-level illumination, ensuring a rapid response to favorable environmental changes. This study identifies the HFR1–PIF1 pair as a central module directing the whole genomic transcriptional network to rapidly initiate light-induced seed germination. PMID:24179122

  14. [Serum diagnosis of head and neck squamous cell carcinoma using surface-enhanced desorption ionization mass spectrometry and artificial neural network analyses].

    Science.gov (United States)

    Cao, Su-Mei; Guo, Xiang; Chen, Fu-Jin; Yang, An-Kui; Chen, Wen-Kuan; Li, Ning-Wei

    2007-07-01

    The early diagnosis of head and neck squamous cell carcinoma (HNSCC) is the key factor that affecting the treatment result. We performed surface-enhanced desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) using a multi-layer artificial neural network (ANN) to develop and evaluate a proteomic diagnosis approach for HNSCC. Serum samples from 74 HNSCC patients and 146 healthy individuals were randomized into training set (148 samples) and test set (72 samples). At first, we detected the training set of samples using SELDI mass spectrometry and WCX2 (weak cation-exchange) chips. Using a multi-layer ANN with a back propagation algorithm, we identified a proteomic pattern that could discriminate cancer from control samples in the training set. The discovered pattern was then used to determine the accuracy of the classification system in the test set. Four top-scored peaks, at m/z (mass/charge) ratio of 4 469 u, 5 924 u, 8 926 u, and 16 697 u, were finally selected as the potential biomarkers for detection of HNSCC with both sensitivity and specificity of 100.0% in the training set. The classifier predicted the HNSCC with sensitivity of 85.7%(18/21) and specificity of 96.1%(49/51) in the test set. SELDI profiling is a useful tool to accurately identify patients with HNSCC.

  15. Expression atlas and comparative coexpression network analyses reveal important genes involved in the formation of lignified cell wall in Brachypodium distachyon.

    Science.gov (United States)

    Sibout, Richard; Proost, Sebastian; Hansen, Bjoern Oest; Vaid, Neha; Giorgi, Federico M; Ho-Yue-Kuang, Severine; Legée, Frédéric; Cézart, Laurent; Bouchabké-Coussa, Oumaya; Soulhat, Camille; Provart, Nicholas; Pasha, Asher; Le Bris, Philippe; Roujol, David; Hofte, Herman; Jamet, Elisabeth; Lapierre, Catherine; Persson, Staffan; Mutwil, Marek

    2017-08-01

    While Brachypodium distachyon (Brachypodium) is an emerging model for grasses, no expression atlas or gene coexpression network is available. Such tools are of high importance to provide insights into the function of Brachypodium genes. We present a detailed Brachypodium expression atlas, capturing gene expression in its major organs at different developmental stages. The data were integrated into a large-scale coexpression database ( www.gene2function.de), enabling identification of duplicated pathways and conserved processes across 10 plant species, thus allowing genome-wide inference of gene function. We highlight the importance of the atlas and the platform through the identification of duplicated cell wall modules, and show that a lignin biosynthesis module is conserved across angiosperms. We identified and functionally characterised a putative ferulate 5-hydroxylase gene through overexpression of it in Brachypodium, which resulted in an increase in lignin syringyl units and reduced lignin content of mature stems, and led to improved saccharification of the stem biomass. Our Brachypodium expression atlas thus provides a powerful resource to reveal functionally related genes, which may advance our understanding of important biological processes in grasses. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  16. 'Joined Up' Local Governments?

    DEFF Research Database (Denmark)

    Bjørnå, Hilde; Casale, Donatella; Hajnal, Gyorgy

    . forthc. 2015, Lægreid et al. 2014, Pollitt 2003). A growing body of research analyses JUG initiatives in several countries, but often in the form of single-case studies with central government focus (see e.g. Talbot 2011 or Lægreid et al. 2014). On municipal level, however, there is only a scarce number...... of such studies and comparative studies are lacking. With this, we ask how can local JUG initiatives be explained and what lessons can be drawn from a comparative perspective? Drawing on some components from the framework by Pollitt and Bouckaert (2011) for public management reforms, we analyse JUG reforms in six...... countries from different administrative traditions (Norway, Italy, Ireland, Hungary, Germany and Austria). First results suggest that in the same way as NPM has claimed to be an “umbrella term for a collection of trends” (Van de Walle/Hammerschmid 2011: 191), also JUG reforms take multiple nuances and foci...

  17. Language management and devolved governance in Kenya ...

    African Journals Online (AJOL)

    ... between language management and devolved governance in Kenya against the backdrop of language management theory and the roles and responsibilities of devolved governance as defined by traditional fiscal federalism, new public management (NPM), public choice, new institutional economics (NIE), and network ...

  18. Governance structures for real estate transactions: Markets ...

    African Journals Online (AJOL)

    This article examines the relative prevalence of markets, hierarchies and networks in the governance of real-estate transactions under three property rights regimes in Windhoek's low-income settlements. These governance structures are related to respective property rights regimes and to conjectures made about the ...

  19. Acting discursively: the development of UK organic food and farming policy networks.

    Science.gov (United States)

    TOMLINSON, Isobel Jane

    2010-01-01

    This paper documents the early evolution of UK organic food and farming policy networks and locates this empirical focus in a theoretical context concerned with understanding the contemporary policy-making process. While policy networks have emerged as a widely acknowledged empirical manifestation of governance, debate continues as to the concept's explanatory utility and usefulness in situations of network and policy transformation since, historically, policy networks have been applied to "static" circumstances. Recognizing this criticism, and in drawing on an interpretivist perspective, this paper sees policy networks as enacted by individual actors whose beliefs and actions construct the nature of the network. It seeks to make links between the characteristics of the policy network and the policy outcomes through the identification of discursively constructed "storylines" that form a tool for consensus building in networks. This study analyses the functioning of the organic policy networks through the discursive actions of policy-network actors.

  20. Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks.

    Science.gov (United States)

    Mai, Hans-Jörg; Pateyron, Stéphanie; Bauer, Petra

    2016-10-03

    FIT (FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR) is the central regulator of iron uptake in Arabidopsis thaliana roots. We performed transcriptome analyses of six day-old seedlings and roots of six week-old plants using wild type, a fit knock-out mutant and a FIT over-expression line grown under iron-sufficient or iron-deficient conditions. We compared genes regulated in a FIT-dependent manner depending on the developmental stage of the plants. We assembled a high likelihood dataset which we used to perform co-expression and functional analysis of the most stably iron deficiency-induced genes. 448 genes were found FIT-regulated. Out of these, 34 genes were robustly FIT-regulated in root and seedling samples and included 13 novel FIT-dependent genes. Three hundred thirty-one genes showed differential regulation in response to the presence and absence of FIT only in the root samples, while this was the case for 83 genes in the seedling samples. We assembled a virtual dataset of iron-regulated genes based on a total of 14 transcriptomic analyses of iron-deficient and iron-sufficient wild-type plants to pinpoint the best marker genes for iron deficiency and analyzed this dataset in depth. Co-expression analysis of this dataset revealed 13 distinct regulons part of which predominantly contained functionally related genes. We could enlarge the list of FIT-dependent genes and discriminate between genes that are robustly FIT-regulated in roots and seedlings or only in one of those. FIT-regulated genes were mostly induced, few of them were repressed by FIT. With the analysis of a virtual dataset we could filter out and pinpoint new candidates among the most reliable marker genes for iron deficiency. Moreover, co-expression and functional analysis of this virtual dataset revealed iron deficiency-induced and functionally distinct regulons.

  1. Patterns for Mobile Open Government Data Applications

    OpenAIRE

    Palka, Wolfgang;Bär, Tobias;Wolf, Petra;Krcmar, Helmut

    2015-01-01

    By making open government data available for public consumption, public administrations or intermediaries implement and operate portals and applications. Due to the fact that information acquisition via mobile devices increased the past years, driven by rapid technical development and availability of a wide-area mobile data network, the provision of open government data via mobile devices is necessary. As a consequence, we focus on mobile open government data applications within our research....

  2. Redes sociais, capital social e governança ambiental no Território Portal da Amazônia Social networks, social capital and environmental governance in the Amazonian Gateway Territory

    Directory of Open Access Journals (Sweden)

    Frédéric Mertens

    2011-01-01

    Full Text Available O artigo trata de um estudo empírico em que a análise de redes sociais é utilizada para mapear o capital social de atores envolvidos em processos de governança ambiental na Amazônia brasileira. Por meio de entrevistas, foi mapeada a rede de relações de diálogo sobre questões socioambientais de um conjunto de 505 atores no Território Portal da Amazônia. Foram identificadas 3384 relações de diálogo, com uma média de 6,7 parceiros de diálogo por ator. A análise dos aspectos estruturais da rede de diálogo foi utilizada para construir indicadores de capital social de ligação, com mapeamento da organização interna dos atores de um mesmo município, e de conexão, com a caracterização das relações entre atores de municípios diferentes. Em nível municipal, a distribuição das duas formas de capital social permitiu caracterizar os grupos de atores de acordo com as suas atuações diferenciadas na governança ambiental do Território. Em nível territorial, o padrão de conectividade entre os 16 municípios mostra um equilíbrio entre as duas formas de capital social e revela o potencial de comunicação e organização dos atores, como demonstrado no exemplo dos projetos de Agendas 21 locais. Estes resultados demonstram como a análise de redes sociais pode contribuir na definição (ou redefinição das fronteiras dos territórios de modo a incluir um conjunto de municípios cujos atores mantêm relações sociais efetivas. Ações de governança no Portal da Amazônia são propostas com potencial para fortalecer os processos de diálogo, diminuir os conflitos e promover o uso sustentável dos recursos naturais na Amazônia.The article presents an empirical study where social network analysis is used to map social capital among actors involved in environmental governance processes in the Brazilian Amazon. Using interviews, we carried out the mapping of the dialogue network regarding socio-environmental issues among 505

  3. Ancestral regulatory circuits governing ectoderm patterning downstream of Nodal and BMP2/4 revealed by gene regulatory network analysis in an echinoderm.

    Directory of Open Access Journals (Sweden)

    Alexandra Saudemont

    2010-12-01

    Full Text Available Echinoderms, which are phylogenetically related to vertebrates and produce large numbers of transparent embryos that can be experimentally manipulated, offer many advantages for the analysis of the gene regulatory networks (GRN regulating germ layer formation. During development of the sea urchin embryo, the ectoderm is the source of signals that pattern all three germ layers along the dorsal-ventral axis. How this signaling center controls patterning and morphogenesis of the embryo is not understood. Here, we report a large-scale analysis of the GRN deployed in response to the activity of this signaling center in the embryos of the Mediterranean sea urchin Paracentrotus lividus, in which studies with high spatial resolution are possible. By using a combination of in situ hybridization screening, overexpression of mRNA, recombinant ligand treatments, and morpholino-based loss-of-function studies, we identified a cohort of transcription factors and signaling molecules expressed in the ventral ectoderm, dorsal ectoderm, and interposed neurogenic ("ciliary band" region in response to the known key signaling molecules Nodal and BMP2/4 and defined the epistatic relationships between the most important genes. The resultant GRN showed a number of striking features. First, Nodal was found to be essential for the expression of all ventral and dorsal marker genes, and BMP2/4 for all dorsal genes. Second, goosecoid was identified as a central player in a regulatory sub-circuit controlling mouth formation, while tbx2/3 emerged as a critical factor for differentiation of the dorsal ectoderm. Finally, and unexpectedly, a neurogenic ectoderm regulatory circuit characterized by expression of "ciliary band" genes was triggered in the absence of TGF beta signaling. We propose a novel model for ectoderm regionalization, in which neural ectoderm is the default fate in the absence of TGF beta signaling, and suggest that the stomodeal and neural subcircuits that we

  4. Between Democracy and Governance

    DEFF Research Database (Denmark)

    Bang, Henrik

    2015-01-01

    collective capacities for representation, participation and deliberation crucial to keeping democratic government responsive, effective and accountable to the common will. On this view, all new forms of connective action are ipso facto rejected as the spawn of neoliberalism: They appear as individualistic....... By contrast, these new actors insist that it is more important to problematize how policy risks and problems are handled by a network of globally interconnected policy elites from the public, private and even voluntary domains. The challenge for democratic political analysis today is to avoid placing...... politicization before problematization or vice versa. This requires a new model which does not identify politics with inputs and thereby relegates outputs to the domain of technical, non-political administration and management. Connective action, I argue, manifests a new model for problematizing how policies...

  5. Privatization Of Global Governance

    Directory of Open Access Journals (Sweden)

    T. J. Biersteker

    2017-01-01

    Full Text Available Thomas Biersteker graduated from Chicago University (BF in Political Science and MIT (MA in Political Science and got PhD in Political Science in MIT as well. Later professor Biersteker lectured in Yale University (1976-1985, South Carolina University (1985-1992 and Brown University (1992-2006. He could be described as a constructivist focusing his research on global governance, international organizations and transnational policy networks, construction of sovereignty and regimes of targeted sanctions. Professor Birsteker kindly agreed to give an interview to the “MGIMO Review of International Relations” during a seminar within the research project - Grant of RFBR No. 16-23-41004. The seminar was also attended by M.M. Lebedeva, Yu.A. Nikitin, A.I. Nikitin, I.A. Istomin.

  6. City Carbon Footprint Networks

    Directory of Open Access Journals (Sweden)

    Guangwu Chen

    2016-07-01

    Full Text Available Progressive cities worldwide have demonstrated political leadership by initiating meaningful strategies and actions to tackle climate change. However, the lack of knowledge concerning embodied greenhouse gas (GHG emissions of cities has hampered effective mitigation. We analyse trans-boundary GHG emission transfers between five Australian cities and their trading partners, with embodied emission flows broken down into major economic sectors. We examine intercity carbon footprint (CF networks and disclose a hierarchy of responsibility for emissions between cities and regions. Allocations of emissions to households, businesses and government and the carbon efficiency of expenditure have been analysed to inform mitigation policies. Our findings indicate that final demand in the five largest cities in Australia accounts for more than half of the nation’s CF. City households are responsible for about two thirds of the cities’ CFs; the rest can be attributed to government and business consumption and investment. The city network flows highlight that over half of emissions embodied in imports (EEI to the five cities occur overseas. However, a hierarchy of GHG emissions reveals that overseas regions also outsource emissions to Australian cities such as Perth. We finally discuss the implications of our findings on carbon neutrality, low-carbon city concepts and strategies and allocation of subnational GHG responsibility.

  7. The Economics of Networking

    DEFF Research Database (Denmark)

    Sørensen, Olav Jull

    The literature on business networks is often oversocialized. The economic side of business is implicitly assumed. This paper analyses the economics of network behavior by loking at each of the key concepts in the Network Theory.......The literature on business networks is often oversocialized. The economic side of business is implicitly assumed. This paper analyses the economics of network behavior by loking at each of the key concepts in the Network Theory....

  8. Minority coalition governance in Denmark

    DEFF Research Database (Denmark)

    Christiansen, Flemming Juul; Pedersen, Helene Helboe

    2014-01-01

    Coalition governance is a challenge for political parties because it involves cooperation and compromises between parties that have different political goals and are competitors in political elections. Coalition coordination is crucial for the intra-coalitional cooperation of the governing parties....... A key element in coalition coordination is coalition agreements, which to a varying degree constrain the behaviour of the coalition partners. This article explores the share of laws that were precisely defined in government agreements and/or legislative agreements, and sets out to explain variation...... in this share of coalition agreement-based laws. The analyses are based on unique data on legislative as well as governmental coalition agreements entered by three Danish governments with varying parliamentary strength. This study brings the blooming literature on coalition agreements one step further...

  9. Transforming governance to enhance social and educational innovation

    Directory of Open Access Journals (Sweden)

    Jacob Torfing

    2016-04-01

    Full Text Available The recent proliferation of governance networks at all levels and in different policy areas has led to a growing number of studies focusing on interactive forms of governance. This paper aims to contribute to the development of governance research by looking at how collaboration in governance networks can help to spur social and educational innovation. The paper begins by defining the concept of governance networks and then provides a systematic overview of different theories that explain the current rise of governance networks. Next, it defines the concept of innovation and discusses how collaboration in networks can enhance innovation. Finally, it discusses how collaborative innovation can be initiated, facilitated and catalysed through new forms of leadership and management.

  10. Engineering governance: introducing a governance meta framework.

    NARCIS (Netherlands)

    Brand, N.; Beens, B.; Vuuregge, E.; Batenburg, R.

    2011-01-01

    There is a need for a framework that depicts strategic choices within an organisation with regard to potential governance structures. The governance meta framework provides the necessary structure in the current developments of governance. Performance as well as conformance are embedded in this

  11. Government and governance strategies in medical tourism

    NARCIS (Netherlands)

    Ormond, M.E.; Mainil, T.

    2015-01-01

    This chapter provides an overview of current government and governance strategies relative to medical tourism development and management around the world. Most studies on medical tourism have privileged national governments as key actors in medical tourism regulation and, in some cases, even

  12. Institutionalizing interactive governance for democracy

    DEFF Research Database (Denmark)

    Sørensen, Eva

    2013-01-01

    Interactive governance arenas such as networks and partnerships are increasingly seen as legitimate and valuable contributions to the production of effective public governance. This effectiveness is not least seen as a result of the self-constituting and self-regulating character of such arenas...... in ensuring democratic inclusion, deliberation and accountability in relation to interactive governance arenas and considers how they can be used to enhance the democratic quality of such arenas through metagovernance.......-institutional theory points out, however, the considerable regulatory impact of ‘soft’ forms of institutionalization such as incentives structures, sedimented normative codes, logics of appropriateness and routinized practices. The article explores the role that soft forms of institutionalization might play...

  13. Governance, decentralisation and deforestation

    NARCIS (Netherlands)

    Suwarno, Aritta; Hein, Lars; Sumarga, Elham

    2015-01-01

    The implementation of the decentralisation policies in Indonesia, which started in 2000, has fundamentally changed the country's forest governance framework. This study investigates how decentralisation has influenced forest governance, and links the forest governance to deforestation rates at

  14. Voluntary Environmental Governance Arrangements

    NARCIS (Netherlands)

    van der Heijden, J.

    2012-01-01

    Voluntary environmental governance arrangements have focal attention in studies on environmental policy, regulation and governance. The four major debates in the contemporary literature on voluntary environmental governance arrangements are studied. The literature falls short of sufficiently

  15. Developing digital forensic governance

    CSIR Research Space (South Africa)

    Grobler, M

    2010-03-01

    Full Text Available This paper presents a Digital Forensic (DF) governance framework and its mapping on the SANS ISO/IEC 38500:2009 Corporate governance of information technology structure. DF governance assists organisations in guiding the management team...

  16. E-Government Dimension

    OpenAIRE

    Rosiyadi, Didi; Suryana, Nana; Cahyana, Ade; Nuryani, Nuryani

    2007-01-01

    Makalah ini mengemukakan E-Government Dimension yang merupakan salah satu hasil TahapanPengumpulan Data, dimana tahapan ini adalah bagian dari penelitian kompetitif di Lembaga Ilmu PengetahuanIndonesia 2007 yang sekarang sedang dilakukan. Data E-Government Dimension ini didapatkan dari berbagaisumber yang meliputi E-Government beberapa Negara di dunia, E-Government yang dibangun oleh beberapapenyedia aplikasi E-Government. E-Government Dimension terdiri dari tiga dimensi yaitu DemocraticDimen...

  17. VT Certified Local Governments

    Data.gov (United States)

    Vermont Center for Geographic Information — Vermont established its Certified Local Government (CLG) program in 1985 to better help local governments integrate historic preservation concerns with planning and...

  18. Limitations of Passively Mapping Logical Network Topologies

    OpenAIRE

    Ayodeji J. Akande; Colin Fidge; Ernest Foo

    2017-01-01

    Understanding logical network connectivity is essential in network topology mapping especially in a fast growing network where knowing what is happening on the network is critical for security purposes and where knowing how network resources are being used is highly important. Mapping logical communication topology is important for network auditing, network maintenance and governance, network optimization, and network security. However, the process of capturing network traffic to generate the...

  19. Faith-based initiatives and the challenges of governance.

    Science.gov (United States)

    Biebricher, Thomas

    2011-01-01

    The task of this paper is to offer an analysis of the Faith-Based and Community Initiative (FBCI) established by George W. Bush and continued under the Obama administration based on a critical and decentred approach to governance (networks). The paper starts out by placing FBCI in the context of the welfare reform of 1996 arguing that both share certain basic assumptions, for example, regarding the nature of poverty, and that FBCI can be interpreted as a response to the relative failure of some aspects of the reform of 1996. In what follows, FBCI is analysed as a typical case of (welfare) state restructuring from government to governance. Emphasis is given to the way discourses and traditions such as communitarianism and public choice have shaped the formation of this new governance arrangement in the field of social service delivery in order to strive for a ‘decentring’ of FBCI by drawing attention to actors' beliefs and worldviews. Finally, I argue that it is not least because of a divergence of such views between policy-makers and faith-based organizations that the effect of FBCI remains for the time being limited.

  20. The External Networking Behaviour of Public Managers

    DEFF Research Database (Denmark)

    Hansen, Morten Balle; Villadsen, Anders Ryom

    2017-01-01

    There has been an increasing focus on managerial external networking behaviour within public administration. While most previous quantitative research has analysed such behaviour one-dimensionally, we suggest a two-dimensional conceptualization based on the concepts of weak and strong ties....... Utilizing measures resembling previous research, we explore the utility of the approach in an exploratory study of Danish local government. Our findings suggest that the two dimensions of external networking behaviour are distinct. We discuss our approach compared to previous approaches and argue...

  1. Performance management in Dutch central government

    NARCIS (Netherlands)

    Mol, Nico P.; de Kruijf, J.A.M.

    2004-01-01

    This article investigates how and to what extent performance indicators in Dutch central government are actually embedded in performance management. In a case study encompassing 12 government organizations, the relevance of the indicators presented is analysed in three stages: (1) with respect to

  2. Public management and governance

    National Research Council Canada - National Science Library

    Bovaird, A. G; Löffler, Elke

    2009-01-01

    ... how the process of governing needs to be fundamentally altered if a government is to retain public trust and make better use of society's resources. Key themes covered include: ■ ■ ■ ■ the challenges and pressures which governments experience in an international context; the changing functions of modern government in the global economy; the 'mixed ec...

  3. Why Governments Intervene

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen; Brown, Dana

    2015-01-01

    Why are national governments increasingly adopting policies on corporate social responsibility (CSR)? Government CSR policies have been explained either as a means of substituting or supporting (mirroring) domestic political-economic institutions and policies, or as a means for government...... that government goals in this regard are not necessarily pre-defined....

  4. Transforming government service

    DEFF Research Database (Denmark)

    Pedersen, Keld

    2017-01-01

    The Danish government has defined an ambitious e-government strategy aiming to increase both citizen centricity and the efficiency of government service production and delivery. This research uses dynamic capability theory to compare a highly successful and a less successful e-government program...

  5. A Monitoring Network for Spectrum Governance Applications

    NARCIS (Netherlands)

    Schiphorst, Roelof; Slump, Cornelis H.; Jondral, Friedrich K.; Dehner, Hanns-Ulrich; Mühlhaus, Michael

    2010-01-01

    Dynamic Spectrum Access (DSA) is an exciting new technology, which introduced a paradigm shift in spectrum access. As a result it also changes the role of the regulator. On one hand the scarce radio spectrum should be used in an optimal way, so that the society is best served. On the other hand

  6. A Monitoring Network for Spectrum Governance

    NARCIS (Netherlands)

    Schiphorst, Roelof; Slump, Cornelis H.

    2010-01-01

    Dynamic Spectrum Access (DSA) is an exciting new technology, which has introduced a paradigm shift in spectrum access. As a result it also changes the role of the regulator. On one hand the scarce radio spectrum should be used in an optimal way, so that society is best served. On the other hand

  7. Research of Transforming Grassroots Government Function Based On Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Sun Kewei

    2015-01-01

    Full Text Available According to principal component analysis theory, through government functions of network platform, performance of organization departments, the software power and information reflected by public to participate in the government network platform construction, to improve the transformation of government function, establish a reasonable standard of government network platform. According to the four secondary indexes, it comprehensive develop 18 evaluation factors as the main factors and targets that influence transformation of town government functions, to get the weight proportion of each index, and analyze on the transformation of town government function in the network era.

  8. Synchronization of networks

    Indian Academy of Sciences (India)

    We study the synchronization of coupled dynamical systems on networks. The dynamics is governed by a local nonlinear oscillator for each node of the network and interactions connecting different nodes via the links of the network. We consider existence and stability conditions for both single- and multi-cluster ...

  9. CORPORATE GOVERNANCE IN ROMANIA. EVOLUTION AND PERSPECTIVES

    Directory of Open Access Journals (Sweden)

    BUȘAN GABRIELA

    2015-03-01

    Full Text Available Thanks to slow way to political, legal, social and economic reform, the corporate governance appears in Romania, from concept and filing, until the early 2000`s. This paper analyzes the evolution of corporate governance in the period 2000-2015, it is presented the OECD principles of corporate governance of companies listed on the Bucharest Stock Exchange and it analyse the situation of the public entities who had the obligation to apply the provisions of O.U.G 109/2011 on corporate governance of public entities and to publish on its Web site the Annual Report

  10. Research, Boundaries, and Policy in Networked Learning

    DEFF Research Database (Denmark)

    This book presents cutting-edge, peer reviewed research on networked learning organized by three themes: policy in networked learning, researching networked learning, and boundaries in networked learning. The "policy in networked learning" section explores networked learning in relation to policy...... networks, spaces of algorithmic governance and more. The "boundaries in networked learning" section investigates frameworks of students' digital literacy practices, among other important frameworks in digital learning. Lastly, the "research in networked learning" section delves into new research methods...

  11. Managing cancer care through service delivery networks: The role of professional collaboration in two European cancer networks.

    Science.gov (United States)

    Prades, Joan; Morando, Verdiana; Tozzi, Valeria D; Verhoeven, Didier; Germà, Jose R; Borras, Josep M

    2017-01-01

    Background The study examines two meso-strategic cancer networks, exploring to what extent collaboration can strengthen or hamper network effectiveness. Unlike macro-strategic networks, meso-strategic networks have no hierarchical governance structures nor are they institutionalised within healthcare services' delivery systems. This study aims to analyse the models of professional cooperation and the tools developed for managing clinical practice within two meso-strategic, European cancer networks. Methods Multiple case study design based on the comparative analysis of two cancer networks: Iridium, in Antwerp, Belgium and the Institut Català d'Oncologia in Catalonia, Spain. The case studies applied mixed methods, with qualitative research based on semi-structured interviews ( n = 35) together with case-site observation and material collection. Results The analysis identified four levels of collaborative intensity within medical specialties as well as in multidisciplinary settings, which became both platforms for crosscutting clinical work between hubs' experts and local care teams and the levers for network-based tools development. The organisation of clinical practice relied on professional-based cooperative processes and tiers, lacking vertical integration mechanisms. Conclusions The intensity of professional linkages largely shaped the potential of meso-strategic cancer networks to influence clinical practice organisation. Conversely, the introduction of managerial techniques or network governance structures, without introducing vertical hierarchies, was found to be critical solutions.

  12. 'Pop-Up' Governance: developing internal governance frameworks for consortia: the example of UK10K.

    Science.gov (United States)

    Kaye, Jane; Muddyman, Dawn; Smee, Carol; Kennedy, Karen; Bell, Jessica

    2015-01-01

    Innovations in information technologies have facilitated the development of new styles of research networks and forms of governance. This is evident in genomics where increasingly, research is carried out by large, interdisciplinary consortia focussing on a specific research endeavour. The UK10K project is an example of a human genomics consortium funded to provide insights into the genomics of rare conditions, and establish a community resource from generated sequence data. To achieve its objectives according to the agreed timetable, the UK10K project established an internal governance system to expedite the research and to deal with the complex issues that arose. The project's governance structure exemplifies a new form of network governance called 'pop-up' governance. 'Pop-up' because: it was put together quickly, existed for a specific period, was designed for a specific purpose, and was dismantled easily on project completion. In this paper, we use UK10K to describe how 'pop-up' governance works on the ground and how relational, hierarchical and contractual governance mechanisms are used in this new form of network governance.

  13. A decade of adaptive governance scholarship: synthesis and future directions

    Directory of Open Access Journals (Sweden)

    Brian C. Chaffin

    2014-09-01

    Full Text Available Adaptive governance is an emergent form of environmental governance that is increasingly called upon by scholars and practitioners to coordinate resource management regimes in the face of the complexity and uncertainty associated with rapid environmental change. Although the term "adaptive governance" is not exclusively applied to the governance of social-ecological systems, related research represents a significant outgrowth of literature on resilience, social-ecological systems, and environmental governance. We present a chronology of major scholarship on adaptive governance, synthesizing efforts to define the concept and identifying the array of governance concepts associated with transformation toward adaptive governance. Based on this synthesis, we define adaptive governance as a range of interactions between actors, networks, organizations, and institutions emerging in pursuit of a desired state for social-ecological systems. In addition, we identify and discuss ambiguities in adaptive governance scholarship such as the roles of adaptive management, crisis, and a desired state for governance of social-ecological systems. Finally, we outline a research agenda to examine whether an adaptive governance approach can become institutionalized under current legal frameworks and political contexts. We suggest a further investigation of the relationship between adaptive governance and the principles of good governance; the roles of power and politics in the emergence of adaptive governance; and potential interventions such as legal reform that may catalyze or enhance governance adaptations or transformation toward adaptive governance.

  14. Nordic Corporate Governance Revisited

    DEFF Research Database (Denmark)

    Thomsen, Steen

    2016-01-01

    This paper reviews the key elements of the Nordic governance model, which include a distinct legal system, high governance ratings and low levels of corruption. Other characteristics include concentrated ownership, foundation ownership, semi two-tier board structures, employee representation...

  15. Government and Business

    DEFF Research Database (Denmark)

    Campbell, John L.

    2015-01-01

    There is a vast literature about the relationships between government and business in advanced capitalist societies.......There is a vast literature about the relationships between government and business in advanced capitalist societies....

  16. Transformative environmental governance

    Science.gov (United States)

    Chaffin, Brian C.; Garmestani, Ahjond S.; Gunderson, Lance H.; Harm Benson, Melinda; Angeler, David G.; Arnold, Craig Anthony (Tony); Cosens, Barbara; Kundis Craig, Robin; Ruhl, J.B.; Allen, Craig R.

    2016-01-01

    Transformative governance is an approach to environmental governance that has the capacity to respond to, manage, and trigger regime shifts in coupled social-ecological systems (SESs) at multiple scales. The goal of transformative governance is to actively shift degraded SESs to alternative, more desirable, or more functional regimes by altering the structures and processes that define the system. Transformative governance is rooted in ecological theories to explain cross-scale dynamics in complex systems, as well as social theories of change, innovation, and technological transformation. Similar to adaptive governance, transformative governance involves a broad set of governance components, but requires additional capacity to foster new social-ecological regimes including increased risk tolerance, significant systemic investment, and restructured economies and power relations. Transformative governance has the potential to actively respond to regime shifts triggered by climate change, and thus future research should focus on identifying system drivers and leading indicators associated with social-ecological thresholds.

  17. Characterization of electromagnetic emission due to power line communication (PLC) networks; Analyses et mesures du rayonnement electromagnetique engendre par des communications haut debit transmises sur des lignes d'energie

    Energy Technology Data Exchange (ETDEWEB)

    Kone, L.; Razafferson, R.; Demoulin, B. [Universite des Sciences et technologies de Lille, IEMN-DHS, Groupe Telice, USTIL, 59 - Villeneuve d' Ascq (France); Moulin, F.; Gauthier, F.; Zeddam, A. [France Telecom R and D, 22 - Lannion (France)

    2005-10-01

    Use of Power Lines Communication for purpose such as Internet access or in-home applications seems to be a very attractive way, however, the problem of conducted and radiated electromagnetic emissions due to these new systems is quite set. The risk of disturbing the Radio communications is, at all, critical in the so-called Short Waves band, from 1 MHz to 30 MHz, allowed to PLC. This paper is aimed in analysing the phenomena that rise to these radiated electromagnetic emissions. We focus especially the analysis to the characterisation of magnetic field by means of simple physical concepts. The experimental and theoretical investigations involve usual power lines owning different dimension and complexity. A large part of this paper is devoted to physical interpretations of the measurement results, underlining the correlation between the magnetic field emission and the common and differential modes currents driven through the line, as well as the connection with the geometrical parameters of the line and with the connected loads. Finally, we present an approach that allows the assessment of the power deliverable by PLC. devices in accordance with the requirements of the harmonized standard EN55022 dealing with conducted emission on the power network. (authors)

  18. Bayesian network meta-analysis suggests a similar effectiveness between a monovalent and a pentavalent rotavirus vaccine: a preliminary report of re-analyses of data from a Cochrane Database Systematic Review.

    Science.gov (United States)

    Takeuchi, Masato

    2014-01-01

    To assess the comparative effectiveness of a monovalent and a pentavalent rotavirus vaccine (RV1 and RV5), a Bayesian network meta-analysis was conducted. Data of randomized trials from the Cochrane Review in 2012 were extracted and synthesized. For the prevention of severe rotavirus disease up to 2 years, no statistical difference was found in the effectiveness between the 2 types of vaccine (odds ratio: 2.23, 95% credible interval: 0.71-5.20). Similarly, the comparative effectiveness of RV1 and RV5 appeared equivalent for other rotavirus-associated outcome measures, such as prevention of severe disease up to 1 year and all severity of rotavirus infections for up to both 1- and 2-year follow-ups. These results indicates that, overall, RV1 and RV5 offer similar benefits to prevent rotavirus diseases; nonetheless, credible intervals are generally wide, highlighting the necessity of further meta-analyses including updated information or, ideally, controlled trials comparing both vaccines directly.

  19. The Knowledge Governance Approach

    DEFF Research Database (Denmark)

    Foss, Nicolai J.

    An attempt is made to characterize a `knowledge governance approach' as a distinctive, emerging field that cuts across the fields of knowledge management, organisation studies, strategy and human resource management. Knowledge governance is taken up with how the deployment of administrative...... with diverse capabilities of handling these transactions. Various open research issues that a knowledge governance approach may illuminate are sketched. Although knowledge governance draws clear inspiration from organizational economics and `rational' organization theory, it recognizes that knowledge...

  20. Maritime governance speed, flow, form process

    CERN Document Server

    Roe, Michael

    2016-01-01

    This book provides an original analysis of the problems facing global governance and in particular that of one of the most globalised of all industries – shipping. Central to all global trade and its dramatic growth, shipping faces difficulties of governance stemming from its every globalised nature. The current characteristics of global governance – nation-state fixation, anachronistic institutions, inadequate stakeholder involvement and an over-domination of owner interests are dwarfed by the problems of stasis and fixation which means that policies to address problems of safety, the environment and security are inadequate. This book provides a full and wide ranging discussion of how governance can be animated in a global context so that the dynamism of the maritime industry and its problems can be prevented, regulated and understood. Its unique approach to governance makes it essential reading for all maritime policy-makers and those analysing maritime issues, alongside those with an interest in govern...

  1. Project governance: selected South African government experiments

    Directory of Open Access Journals (Sweden)

    G. van der Walt

    2008-07-01

    Full Text Available Some form of accountability and power structure binds all organisations. Such structures are typically referred to as the “governance” structure of the organisation. In organisations that have relatively mature project applications and methodologies in place, governance mechanisms are established on more permanent bases. With its focus on performance, results and outcomes, project governance establishes decision-making structures, as well as accountability and responsibility mechanisms in public institutions to oversee projects. As government institutions increasingly place emphasis on project applications for policy implementation and service delivery initiatives, mechanisms or structures should be established to facilitate clear interfaces between the permanent organisation and the temporary project organisation. Such mechanisms or structures should enhance the governance of projects, that is, the strategic alignment of projects, the decentralisation of decision- making powers, rapid resource allocation, and the participation of external stakeholders. The purpose of this article is to explore the concept “project governance”, and to highlight examples of project governance as applied in selected government departments in provincial and national spheres. This would enable the establishment of best practice examples and assist to develop benchmarks for effective project applications for service delivery improvement.

  2. Transformative environmental governance

    Science.gov (United States)

    Transformative governance is an approach to environmental governance that has the capacity to respond to, manage, and trigger regime shifts in coupled social-ecological systems (SESs) at multiple scales. The goal of transformative governance is to actively shift degraded SESs to ...

  3. Government failure : four types

    NARCIS (Netherlands)

    Dolfsma, W.A.

    Economists tend to see the market as a default option for social order and a role for government only when markets fail. Developing a convincing analysis of the role of government in economic processes, however, needs to start by considering government failure in its own terms. Drawing on insights

  4. Global water governance

    NARCIS (Netherlands)

    Gupta, J.; Falkner, R.

    2013-01-01

    Although (fresh) water challenges are primarily local in nature, globalization has led to feedback effects that make many water challenges global in nature. This chapter examines global water governance. It discusses four phases of water governance, argues that water governance is dispersed and

  5. Chain governance in the market for electricity. A vision on how to deal with dependencies in the present and future Dutch electricity market

    International Nuclear Information System (INIS)

    Van Duren, M.

    2006-10-01

    The objective of this study is to develop a vision on the organization of the chain governance model for the electricity market in the present and in the future. Chapter 2 describes the complex electricity market, addressing the dependencies between market parties. Chapter 3 describes how enterprises can offer security internally with respect to reliability of processes and information, based on theory about 'governance' and internal management. Chapter 4 describes how external security can be offered in the electricity market based on theory about chains, networks and governance. Chapter 5 analyses the organization of the chain governance model in the current elecricity market. The developments that are anticipated affect the dependencies. Combined with the analysis a vision is formulated for organizing the chain governance model in view of offering security for the future electricity market. [mk] [nl

  6. Size of government and entrepreneurship. Analysis of three groups of countries with different economic development

    Directory of Open Access Journals (Sweden)

    Juan Carlos Díaz Casero

    2015-07-01

    Full Text Available This study analyzes the impact of the "size of government" in entrepreneurial activity for countries with different levels of economical development. It has been used the variables "size of government" of the economic freedom indices released by the Economic Freedom Network (2000-2009 and by The Heritage Foundation (2000-2011, and the variables of "entrepreneurship" released by the Global Entrepreneurship Monitor. Furthermore, the same analysis has been carried out grouping the countries by development level, following the classification elaborated by the World Economic Forum. Statistical analyses of correlations have shown that the “size of government” is related to entrepreneurship. The variables "Size of Government: Expenditures, Taxes and Enterprises" and " Government Size” have revealed a positive correlation with the total, opportunity and necessity entrepreneurial activity indices for the economies based on efficiency and innovation, thus less taxes on income and lower government spending, increase the entrepreneurship of the country. In “factor driven economies”, there is no relationship between the size of government and entrepreneurship

  7. Governance and organizational theory

    Directory of Open Access Journals (Sweden)

    Carlos E. Quintero Castellanos

    2017-07-01

    Full Text Available The objective of this essay is to propose a way to link the theoretical body that has been weaved around governance and organizational theory. For this, a critical exposition is done about what is the theoretical core of governance, the opportunity areas are identified for the link of this theory with organizational theory. The essay concludes with a proposal for the organizational analysis of administrations in governance. The essay addresses with five sections. The first one is the introduction. In the second one, I present a synthesis of the governance in its current use. In the next one are presented the work lines of the good governance. In the fourth part, I show the organizational and managerial limits in the governance theory. The last part develops the harmonization proposal for the governance and organizational theories.

  8. A novel gene's role in an ancient mechanism: secreted Frizzled-related protein 1 is a critical component in the anterior-posterior Wnt signaling network that governs the establishment of the anterior neuroectoderm in sea urchin embryos.

    Science.gov (United States)

    Khadka, Anita; Martínez-Bartolomé, Marina; Burr, Stephanie D; Range, Ryan C

    2018-01-01

    The anterior neuroectoderm (ANE) in many deuterostome embryos (echinoderms, hemichordates, urochordates, cephalochordates, and vertebrates) is progressively restricted along the anterior-posterior axis to a domain around the anterior pole. In the sea urchin embryo, three integrated Wnt signaling branches (Wnt/β-catenin, Wnt/JNK, and Wnt/PKC) govern this progressive restriction process, which begins around the 32- to 60-cell stage and terminates by the early gastrula stage. We previously have established that several secreted Wnt modulators of the Dickkopf and secreted Frizzled-related protein families (Dkk1, Dkk3, and sFRP-1/5) are expressed within the ANE and play important roles in modulating the Wnt signaling network during this process. In this study, we use morpholino and dominant-negative interference approaches to characterize the function of a novel Frizzled-related protein, secreted Frizzled-related protein 1 (sFRP-1), during ANE restriction. sFRP-1 appears to be related to a secreted Wnt modulator, sFRP3/4, that is essential to block Wnt signaling and establish the ANE in vertebrates. Here, we show that the sea urchin sFRP3/4 orthologue is not expressed during ANE restriction in the sea urchin embryo. Instead, our results indicate that ubiquitously expressed maternal sFRP-1 and Fzl1/2/7 signaling act together as early as the 32- to 60-cell stage to antagonize the ANE restriction mechanism mediated by Wnt/β-catenin and Wnt/JNK signaling. Then, starting from the blastula stage, Fzl5/8 signaling activates zygotic sFRP-1 within the ANE territory, where it works with the secreted Wnt antagonist Dkk1 (also activated by Fzl5/8 signaling) to antagonize Wnt1/Wnt8-Fzl5/8-JNK signaling in a negative feedback mechanism that defines the outer ANE territory boundary. Together, these data indicate that maternal and zygotic sFRP-1 protects the ANE territory by antagonizing the Wnt1/Wnt8-Fzl5/8-JNK signaling pathway throughout ANE restriction, providing precise

  9. A novel gene’s role in an ancient mechanism: secreted Frizzled-related protein 1 is a critical component in the anterior–posterior Wnt signaling network that governs the establishment of the anterior neuroectoderm in sea urchin embryos

    Directory of Open Access Journals (Sweden)

    Anita Khadka

    2018-01-01

    Full Text Available Abstract The anterior neuroectoderm (ANE in many deuterostome embryos (echinoderms, hemichordates, urochordates, cephalochordates, and vertebrates is progressively restricted along the anterior–posterior axis to a domain around the anterior pole. In the sea urchin embryo, three integrated Wnt signaling branches (Wnt/β-catenin, Wnt/JNK, and Wnt/PKC govern this progressive restriction process, which begins around the 32- to 60-cell stage and terminates by the early gastrula stage. We previously have established that several secreted Wnt modulators of the Dickkopf and secreted Frizzled-related protein families (Dkk1, Dkk3, and sFRP-1/5 are expressed within the ANE and play important roles in modulating the Wnt signaling network during this process. In this study, we use morpholino and dominant-negative interference approaches to characterize the function of a novel Frizzled-related protein, secreted Frizzled-related protein 1 (sFRP-1, during ANE restriction. sFRP-1 appears to be related to a secreted Wnt modulator, sFRP3/4, that is essential to block Wnt signaling and establish the ANE in vertebrates. Here, we show that the sea urchin sFRP3/4 orthologue is not expressed during ANE restriction in the sea urchin embryo. Instead, our results indicate that ubiquitously expressed maternal sFRP-1 and Fzl1/2/7 signaling act together as early as the 32- to 60-cell stage to antagonize the ANE restriction mechanism mediated by Wnt/β-catenin and Wnt/JNK signaling. Then, starting from the blastula stage, Fzl5/8 signaling activates zygotic sFRP-1 within the ANE territory, where it works with the secreted Wnt antagonist Dkk1 (also activated by Fzl5/8 signaling to antagonize Wnt1/Wnt8–Fzl5/8–JNK signaling in a negative feedback mechanism that defines the outer ANE territory boundary. Together, these data indicate that maternal and zygotic sFRP-1 protects the ANE territory by antagonizing the Wnt1/Wnt8–Fzl5/8–JNK signaling pathway throughout ANE

  10. The Effectiveness of Social Media Implementation at Local Government Levels

    Directory of Open Access Journals (Sweden)

    Elvira NICA

    2014-12-01

    Full Text Available The purpose of this article is to gain a deeper understanding of the management of social me-dia at the local government level, the availability of opportunities for citizen dialogue on govern-ment websites, and the impact that social net-working applications have on e-government. The results of the current study converge with prior research on the growing awareness amongst government practitioners regarding the relevance of social media, the use of social media for feed-back on service quality, and privacy and security commitments in e-government. The literature on the use of information technology to transform government, the potential for online government information to contribute to citizen engagement, and the rapid growth in local government use of social media is relevant to this discussion.

  11. Governance or Governing – the Missing Link?

    Directory of Open Access Journals (Sweden)

    Luminiţa Maria Crăciun

    2010-07-01

    Full Text Available Governance and governing are two distinct concepts, but they intertwine. “Good governing” exercises good influence on development. “Good governance” supposes first a relationship of power focused on a series of reforms structured at three levels: the political – administrative level, the economic level, and the level of civil society. As this dimension is difficult to measure, the qualitative evaluation of the governing act raised the interest of the World Bank researchers, who elaborated and monitored the dynamics of a set of indicators, which includes six major dimensions of the governing. A retrospective concerning the image of governing in Romania during the period from 1996 to 2005 suggests a modest increase of the score: from -0.138 (1996 to 0.008 (2002; that was partially achieved based on the voice and responsibility index and on the political stability index, not on those that measure more directly the administrative performance or the integrity of the governing act. For a comparative study, we chose seven countries for the purposes of analysis (two new European Union member states: Romania and Bulgaria; two older member countries of the European Union: Slovenia and Latvia; three non-member states: Moldova, Ukraine, and Georgia, which reveal the quality of the governing from a comparative perspective. Corruption control completes the image created by the analyzed indicators. The mere formal accomplishment of commitments made in the pre-accession activity, doubled by recent internal evolutions, bring doubts about the credibility of the anticorruption reforms, as Romania continues to be considered the country with the highest CPI in the European Union. The pessimism of public opinion and the fact that only 34% of the Romanian people consider that the level of corruption will decrease in the following three years constitutes an alarm signal addressed to the governance, in view of the real reformation of the administration system

  12. Designing government: from instruments to governance

    National Research Council Canada - National Science Library

    Eliadis, F. Pearl; Hill, Margaret M; Howlett, Michael

    2005-01-01

    ... Selection and Implementation in a Networked Context 132 Hans Th.A. Bressers and Laurence J. O'Toole, Jr Choosing among Forms of Public Action: A Question of Legitimacy 154 Pierre Issalys 8 9 10 11 12 1...

  13. Government bond yields and foreign ownership of debt

    NARCIS (Netherlands)

    Broos, Menno; de Haan, Jakob

    2012-01-01

    We analyse the government bond yield spread vis-a-vis Germany for 10 countries in the euro area for the period 1991 to 2009. Our results suggest a positive relationship between the marginal impact of government debt on the spread and foreign ownership of the government debt of the country concerned

  14. 42 CFR 494.180 - Condition: Governance.

    Science.gov (United States)

    2010-10-01

    ... Administration § 494.180 Condition: Governance. The ESRD facility is under the control of an identifiable... limited to— (1) Staff appointments; (2) Fiscal operations; (3) The relationship with the ESRD networks... registered nurse, social worker and dietitian members of the interdisciplinary team are available to meet...

  15. Multi-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L. Exposed to Water Deficit

    Directory of Open Access Journals (Sweden)

    Stefania Savoi

    2017-07-01

    Full Text Available Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids, anthocyanins, and free volatile organic compounds have been previously observed in grape berries exposed to water deficit. Integrating RNA-sequencing analysis of the transcriptome with large-scale analysis of central and specialized metabolites, we reveal that these increases occur via a coordinated regulation of key structural pathway genes. Water deficit-induced up-regulation of flavonoid genes is also coordinated with the down-regulation of many stilbene synthases and a consistent decrease in stilbenoid concentration. Water deficit activated both ABA-dependent and ABA-independent signal transduction pathways by modulating the expression of several transcription factors. Gene-gene and gene-metabolite network analyses showed that water deficit-responsive transcription factors such as bZIPs, AP2/ERFs, MYBs, and NACs are implicated in the regulation of stress-responsive metabolites. Enrichment of known and novel cis-regulatory elements in the promoters of several ripening-specific/water deficit-induced modules further affirms the involvement of a transcription factor cross-talk in the berry response to water deficit. Together, our integrated approaches show that water deficit-regulated gene modules are strongly linked to key fruit-quality metabolites and multiple signal transduction pathways may be critical to achieve a balance between the regulation of the stress-response and the berry ripening program. This study constitutes an invaluable resource for future discoveries and comparative studies, in grapes and other fruits, centered on reproductive tissue metabolism under abiotic stress.

  16. The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA): Data on mortality, by HIV status and stage on the HIV care continuum, among the general population in seven longitudinal studies between 1989 and 2014.

    Science.gov (United States)

    Slaymaker, Emma; McLean, Estelle; Wringe, Alison; Calvert, Clara; Marston, Milly; Reniers, Georges; Kabudula, Chodziwadziwa Whiteson; Crampin, Amelia; Price, Alison; Michael, Denna; Urassa, Mark; Kwaro, Daniel; Sewe, Maquins; Eaton, Jeffrey W; Rhead, Rebecca; Nakiyingi-Miiro, Jessica; Lutalo, Tom; Nabukalu, Dorean; Herbst, Kobus; Hosegood, Victoria; Zaba, Basia

    2017-11-06

    Timely progression of people living with HIV (PLHIV) from the point of infection through the pathway from diagnosis to treatment is important in ensuring effective care and treatment of HIV and preventing HIV-related deaths and onwards transmission of infection.  Reliable, population-based estimates of new infections are difficult to obtain for the generalised epidemics in sub-Saharan Africa.  Mortality data indicate disease burden and, if disaggregated along the continuum from diagnosis to treatment, can also reflect the coverage and quality of different HIV services.  Neither routine statistics nor observational clinical studies can estimate mortality prior to linkage to care nor following disengagement from care.  For this, population-based data are required. The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa brings together studies in Kenya, Malawi, South Africa, Tanzania, Uganda, and Zimbabwe.  Eight studies have the necessary data to estimate mortality by HIV status, and seven can estimate mortality at different stages of the HIV care continuum.  This data note describes a harmonised dataset containing anonymised individual-level information on survival by HIV status for adults aged 15 and above. Among PLHIV, the dataset provides information on survival during different periods: prior to diagnosis of infection; following diagnosis but before linkage to care; in pre-antiretroviral treatment (ART) care; in the first six months after ART initiation; among people continuously on ART for 6+ months; and among people who have ever interrupted ART.

  17. Multi-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis viniferaL.) Exposed to Water Deficit.

    Science.gov (United States)

    Savoi, Stefania; Wong, Darren C J; Degu, Asfaw; Herrera, Jose C; Bucchetti, Barbara; Peterlunger, Enrico; Fait, Aaron; Mattivi, Fulvio; Castellarin, Simone D

    2017-01-01

    Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids, anthocyanins, and free volatile organic compounds have been previously observed in grape berries exposed to water deficit. Integrating RNA-sequencing analysis of the transcriptome with large-scale analysis of central and specialized metabolites, we reveal that these increases occur via a coordinated regulation of key structural pathway genes. Water deficit-induced up-regulation of flavonoid genes is also coordinated with the down-regulation of many stilbene synthases and a consistent decrease in stilbenoid concentration. Water deficit activated both ABA-dependent and ABA-independent signal transduction pathways by modulating the expression of several transcription factors. Gene-gene and gene-metabolite network analyses showed that water deficit-responsive transcription factors such as bZIPs, AP2/ERFs, MYBs, and NACs are implicated in the regulation of stress-responsive metabolites. Enrichment of known and novel cis -regulatory elements in the promoters of several ripening-specific/water deficit-induced modules further affirms the involvement of a transcription factor cross-talk in the berry response to water deficit. Together, our integrated approaches show that water deficit-regulated gene modules are strongly linked to key fruit-quality metabolites and multiple signal transduction pathways may be critical to achieve a balance between the regulation of the stress-response and the berry ripening program. This study constitutes an invaluable resource for future discoveries and comparative studies, in grapes and other fruits, centered on reproductive tissue metabolism under abiotic stress.

  18. Good governance and corruption in the health sector: lessons from the Karnataka experience.

    Science.gov (United States)

    Huss, R; Green, A; Sudarshan, H; Karpagam, Ss; Ramani, Kv; Tomson, G; Gerein, N

    2011-11-01

    Strengthening good governance and preventing corruption in health care are universal challenges. The Karnataka Lokayukta (KLA), a public complaints agency in Karnataka state (India), was created in 1986 but played a prominent role controlling systemic corruption only after a change of leadership in 2001 with a new Lokayukta (ombudsman) and Vigilance Director for Health (VDH). This case study of the KLA (2001-06) analysed the:Scope and level of poor governance in the health sector; KLA objectives and its strategy; Factors which affected public health sector governance and the operation of the KLA. We used a participatory and opportunistic evaluation design, examined documents about KLA activities, conducted three site visits, two key informant and 44 semi-structured interviews and used a force field model to analyse the governance findings. The Lokayukta and his VDH were both proactive and economically independent with an extended social network, technical expertise in both jurisdiction and health care, and were widely perceived to be acting for the common good. They mobilized media and the public about governance issues which were affected by factors at the individual, organizational and societal levels. Their investigations revealed systemic corruption within the public health sector at all levels as well as in public/private collaborations and the political and justice systems. However, wider contextual issues limited their effectiveness in intervening. The departure of the Lokayukta, upon completing his term, was due to a lack of continued political support for controlling corruption. Governance in the health sector is affected by positive and negative forces. A key positive factor was the combined social, cultural and symbolic capital of the two leaders which empowered them to challenge corrupt behaviour and promote good governance. Although change was possible, it was precarious and requires continuous political support to be sustained.

  19. Governance Strategies for a Sustainable Digital World

    Directory of Open Access Journals (Sweden)

    Igor Linkov

    2018-02-01

    Full Text Available Digitalization is changing society by the increased connectivity and networking that digital technologies enable, such as enhancing communication, services, and trade. Increasingly, policymakers within various national governments and international organizations such as the United Nations (UN and Organization for Economic Co-operation and Development (OECD are examining the original sustainability policy concepts applied within the Brundtland Report of 1987 through the lens of digitalization. While the growth of a digital economy may increase productivity and benefit local and global economies, digitalization also raises potential sustainability challenges pertaining to social (i.e., the benefits or costs imposed by disruptive digital technologies upon social networks and ways of life, including threats to economic sustainability and the rise of economic disparity and environmental wellbeing (i.e., natural resource stewardship and concern for future generations driven by the automation of information processing and delivery of services. Various perspectives have been raised regarding how the process of digitalization might be governed, and national governments remain at odds regarding a single best strategy to promote sustainable digitalization using the Brundtland concept to meet the development needs of the present without compromising the needs of future generations (i.e., social and environmental well-being. This paper reviews three governance strategies that countries can use in conjunction with adaptive governance to respond to digitalization sustainability threats: (i a laissez-faire, industry-driven approach; (ii a precautionary and preemptive strategy on the part of government; and (iii a stewardship and “active surveillance” approach by government agencies that reduce the risks derived from digitalization while promoting private sector innovation. Regardless of a state’s digital governance response and how it is shaped by

  20. Toward an E-Government Semantic Platform

    Science.gov (United States)

    Sbodio, Marco Luca; Moulin, Claude; Benamou, Norbert; Barthès, Jean-Paul

    This chapter describes the major aspects of an e-government platform in which semantics underpins more traditional technologies in order to enable new capabilities and to overcome technical and cultural challenges. The design and development of such an e-government Semantic Platform has been conducted with the financial support of the European Commission through the Terregov research project: "Impact of e-government on Territorial Government Services" (Terregov 2008). The goal of this platform is to let local government and government agencies offer online access to their services in an interoperable way, and to allow them to participate in orchestrated processes involving services provided by multiple agencies. Implementing a business process through an electronic procedure is indeed a core goal in any networked organization. However, the field of e-government brings specific constraints to the operations allowed in procedures, especially concerning the flow of private citizens' data: because of legal reasons in most countries, such data are allowed to circulate only from agency to agency directly. In order to promote transparency and responsibility in e-government while respecting the specific constraints on data flows, Terregov supports the creation of centrally controlled orchestrated processes; while the cross agencies data flows are centrally managed, data flow directly across agencies.

  1. Civil Society and Governance

    DEFF Research Database (Denmark)

    Hulgård, Lars

    An illustration of how important the relationship is between civil society anbd governance. A short historic journey with four snapshots of times and situations that have provided interesting evidence about the connection between civil society and governance. My goal for the short historic journey...... is to make clear and hopefully even verify that providing knowledge about the impact of civil society and citizens’ participation on governance is one of the most urgent research tasks in the current period of time....

  2. Internet Governance: An Introduction

    OpenAIRE

    Arthur J. Cordell; Prabir K. Neogi

    2007-01-01

    Internet Governance: An Introduction offers a complete guide to the “ins and outs” of Internet governance. Drawing on a range of international authors Internet Governance is best suited for those seeking an overview of the range of issues involved as the Internet becomes increasingly important to bu siness and to society in general, affecting the daily lives of millions of people around the world.

  3. Energy Efficiency Governance: Handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This handbook has been written to assist EE practitioners, government officials and stakeholders to establish effective EE governance structures for their country. The handbook provides readers with relevant information in an accessible format that will help develop comprehensive and effective governance mechanisms. For each of the specific topics dealt with (see Figure 1 in the Handbook), the IEA offers guidelines for addressing issues, or directs readers to examples of how such issues have been dealt with by specific countries.

  4. Exploring Knowledge Governance

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Mahoney, Joseph T

    Knowledge governance is characterized as a distinctive research subject, the understanding of which cuts across diverse fields in management. In particular, it represents an intersection of knowledge management, strategic management, and theories of the firm. Knowledge governance considers how...... deployment of governance mechanisms influences knowledge processes: sharing, retaining, and creating knowledge. We survey the papers in this volume of the special issue, and discuss the remaining research challenges....

  5. Governing through standards

    DEFF Research Database (Denmark)

    Brøgger, Katja

    This abstract adresses the ways in which new education standards have become integral to new modes of education governance. The paper explores the role of standards for accelerating the shift from national to transnational governance in higher education. Drawing on the case of higher education...... development in Scandinavia, the paper focuses on the unintended effects of the new international standards. The Bologna process was reframed and recontextualized in ways that undermined the very system it was set out to transform and govern....

  6. Governing the transition to natural gas in Mediteranean Metropolis: The case of Cairo, Istanbul and Sfax (Tunisia)

    International Nuclear Information System (INIS)

    Verdeil, Éric; Arik, Elvan; Bolzon, Hugo; Markoum, Jimmy

    2015-01-01

    Recent scholarship on urban energy governance has focused on low carbon energy strategies seen as a response to climate change and energy pressure threats. But such approaches tend to overlook the situations of cities from the Global South and emerging countries concerned with strong energy demand growth. The development of urban natural gas networks is an understudied response to such a challenge. Focusing on three cities, Istanbul, Cairo and Sfax (Tunisia), the article analyses the factors and the governance of these energy transitions. It uses a geographical approach to such processes that highlight the mutual influence of the territory in its material and political dimensions and of the policy goals and tools in the implementation. The development of urban gas networks rests upon the proximity of gas deposits. It is determined by metropolitan strategies for economic development as well as by programs aiming to cut energy subsidies. Though urban gas networks have a strong potential for restructuring the physical and social landscapes in cities, the dominant commercial approach taken by energy utilities and morphological constraints in the urban fabric limit their universalization. Natural gas is part of a mix of energies at the urban level and often competes with other energy forms, specifically renewables (like solar water heaters). Lastly, the development of urban natural gas networks sparks heated politics in relation to unfulfilled energy demand and affordability. - Highlights: • Considers the governance of natural gas networks in emerging cities. •Adopts a geographical approach looking at interactions between natural gas infrastructure and urban space. • Switch to natural gas linked to financial purpose (subsidy cuts) more than concern for climate change. • Switch to natural gas shaped by policies governing other urban energy forms. • Urban politics and issues of affordability impact the governance of natural gas transition

  7. Gobernanza Versus Gobierno Governance Versus Government

    Directory of Open Access Journals (Sweden)

    Dany-Robert Dufour

    2009-06-01

    Full Text Available El desplazamiento del término moderno de gobierno por el postmoderno de gobernanza, pone de manifiesto un nuevo lenguaje postmoderno en el que se deja entrever que ambas nociones, gobierno y gobernanza, tienden a oponerse. La gobernanza corporativa designa la toma del poder del capitalismo financiero sobre el capitalismo industrial, que no es otra cosa que, por un lado, propender por la rentabilidad máxima para los accionistas, valorizar todo en el mercado sin consideraciones morales, obligar a los actores a la búsqueda de riesgo permanente y flexibilizar las relaciones jerárquicas en la Administración de la empresa; y por el otro, la marginación de la clase obrera. La gobernanza ha llegado a los asuntos políticos convirtiéndose en modelo de gestión pública por excelencia, ella trata que el gobierno reducido a su mínima expresión guie a una sociedad civil que adquiere un papel importante en la creación y seguimiento de las diferentes políticas, es decir, que el gobierno adquiere una forma flexible de regulación, es allá donde la gobernanza política nos conduce, a la supuesta autorregulación de los intereses privados que sumados pasan a configurar el interés general. En realidad se trata de una nueva forma de dominación marcada por un desvanecimiento político, donde la sociedad civil juega en contra del Estado. La gobernanza le está tendiendo una temible trampa a la democracia, en tanto se presenta como una ampliación de la democracia materializada en una mejor participación de la sociedad civil, destruyendo la persona pública que se forma por la unión de todos los otros y convirtiéndola en representante de intereses particulares.The displacement of the modern term of government for the postmodern one of governance, reveals a new postmodern language in which one is left to guess that both notions, government and governance, tend to be opposed. Corporate governance signifies the seizure of power of financial capitalism

  8. E-Government Partnerships Across Levels of Government

    OpenAIRE

    Charbit, Claire; Michalun, Varinia

    2009-01-01

    E-government Partnerships across Levels of Government, is an overview of the challenges and approaches to creating a collaborative and cooperative partnership across levels of government for e-government development and implementation.

  9. Local Government Strategy Series

    Science.gov (United States)

    An overview for policy makers and program implementers of greenhouse gas emissions reduction strategies that local governments can use to achieve economic, environmental, social, and human health benefits.

  10. The Size and Structure of Government

    OpenAIRE

    Michael, Bryane; Popov, Maja

    2015-01-01

    Does government size and structure adapt to changes in government’s organisational environment (particularly to uncertainty and complexity) as predicted by organisational theory? We find – using a range of statistical analyses – support for each of the major theories of organisation adaptation (the contingency-based view, resource-based view, and rational choice view). We find that both government size and structure change – holding other factors constant – for changes in the uncertaint...

  11. Liberalisation in network based industries. An economic analysis by case studies of railway, telecommunication and energy utilities; Liberalisierung von Netzindustrien. Eine oekonomische Analyse am Beispiel der Eisenbahn, der Telekommunikation und der Leitungsgebundenen Energieversorgung

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, A.

    2006-07-01

    The liberalisation of network based industries represents an economic problem, which raises on the one hand a multiplicity of theoretically unresolved questions and for which exist now on the other hand experiences in economic policy in Germany. The causes of the economic problems are not only to be found thereby in certain industry characteristics of the network based industries, but also in a missed special treatment of the network based economic sectors in the past by the economic policy. However, competition pushes in network based industries at borders, because the infrastructure necessary for the production of network based services typically represents an non-open to attack, natural monopoly in the hand of an established, vertically integrated supplier. From it extensive possibilities for the discrimination of competitors result, the competition political action need draw. It applies to analyze these in the available work and to discuss alternative solutions of the discrimination problem. (orig.)

  12. Survey and analysis of how a network owner using the Albatross KIS system processes information on settlement and measurement; Kartlegging og analyse av behandling av maale- og avregningsinformasjon hos netteier med Albatross KIS-system

    Energy Technology Data Exchange (ETDEWEB)

    Graabak, Ingeborg; Saele, Hanne

    1999-01-01

    Four different customer information systems (KIS) are currently widely used in Norway. These are N-KIS, Albatross, Infotron and Elis. The KIS type of system is supposed to be important for how the information is handled by the individual network owners. Troms Kraft Nett AS was chosen to represent the network owners that are using Albatross. The objective of the survey was to develop documentation and competence on the network owners' use of measurement and settlement information. Based on this competence, the project will attempt to suggest rationalization measures. The survey emphasizes the new tasks imposed on the network owners in connection with the deregulation of the Norwegian power market. The report recommends specific measures to rationalize the information management at Troms Kraft Nett AS and general measures to be evaluated in the EFFEKT project ''Rational information management with the network owner''.

  13. Partnerships in primary care in Australia: network structure, dynamics and sustainability.

    Science.gov (United States)

    Lewis, Jenny M; Baeza, Juan I; Alexander, Damon

    2008-07-01

    Partnerships represent a prescriptive form of network governance, based on the idea of cooperation. This article has four aims. The first is to describe why network governance and partnerships are important now, and what one particular example - Primary Care Partnerships - is addressing. The second is to analyse the network structure of two of these partnerships, and the third is to examine network dynamics. The fourth aim is to explore relationships and sustainability over the longer term. Two government-funded and steered partnerships, which were established to increase coordination between primary care services in Victoria, Australia, were examined. Annual interviews at three points in time between 2002 and 2005 were used to explore relationships between organizations within these two partnerships. The structure of two different communication networks, based on contacts for work and contacts for strategic information, were examined using social network analysis. Tracing network structures over time highlighted partnership dynamics. The network structures changed over the three years of the study, but an important constant was the continuing centrality of the independent staff employed to manage the partnerships. Over the longer term, it seems to be more important to fund independent partnership staff, rather than people who connect partnerships to the funding agency. If partnerships are seen as valuable in improving service coordination and health outcomes, then long term rather than just start-up funding support is required.

  14. Human-centred Governance

    DEFF Research Database (Denmark)

    Bason, Christian

    2017-01-01

    Design approaches are now being applied all over the world as a powerful approach to innovating public policies and services. Christian Bason, author of Leading public design: Discovering human-centred governance, argues that by bringing design methods into play, public managers can lead change...... with citizens at the centre, and discover a new model for steering public organisations: human-centred governance....

  15. Australian Government Information Resources

    OpenAIRE

    Chapman, Bert

    2017-01-01

    Provides an overview of Australian Government information resources. Features content from Australian Government agency websites such as the Department of Environment and Energy, Department of Defence, Australian National Maritime Museum, ANZAC Memorial in Sydney, Department of Immigration & Border Protection, Australian Bureau of Statistics, Australian Dept. of Agriculture and Water Resources, Australian Parliament, Australian Treasury, Australian Transport Safety Board, and Australian Parl...

  16. Negotiating Collaborative Governance Designs

    DEFF Research Database (Denmark)

    Plotnikof, Mie

    2017-01-01

    This chapter addresses the design and implementation issues of collaborative governance, a public management practice aimed at involving stakeholders in problem-solving and public innovation.......This chapter addresses the design and implementation issues of collaborative governance, a public management practice aimed at involving stakeholders in problem-solving and public innovation....

  17. Governance and growth revisited

    NARCIS (Netherlands)

    Seldadyo, H.; de Haan, J.; Pandu Nugroho, E.

    2007-01-01

    Recent studies yield diverging outcomes on the governance-growth relationship. In this paper we construct a new index of governance using a latent variable approach and test whether this index is related to growth with varying samples of countries and different conditioning variables. The results

  18. Making Government Liquid

    DEFF Research Database (Denmark)

    du Gay, Paul; Millo, Yuval; Tuck, Penelope

    2012-01-01

    The financialised character of contemporary rationalities of public governance has been the subject of increased attention within a range of disciplinary and interdisciplinary fields. With this paper we propose a particular analytical framework, focused on the notion of 'governance devices', for ...

  19. Educational Governance in Denmark

    Science.gov (United States)

    Moos, Lejf

    2014-01-01

    Denmark has entered global competition by expanding collaboration with European countries, which is profoundly impacting the public sector and school governance. Relations between the state and institutions are transforming from traditional democratic, public-sector models of governance into new forms characterized as corporate and market-driven…

  20. Community College Governance.

    Science.gov (United States)

    Wyoming Community Coll. Commission, Cheyenne.

    This report presents the findings of the state legislature's Management Audit Committee's review of the structure and governance of community colleges in Wyoming, as requested by the Legislature's Management Council in September 1998. In trying to answer questions about the structure of community college governance, the tensions present in the…

  1. Using IT Governance

    Science.gov (United States)

    Brobst, Jan; Council, Chip

    2005-01-01

    The discussion in this article is intended to provide an examination of why top management, IT management, and internal auditors should be interested in IT governance. Some aspects of IT management will be described including implementation, auditing, availability, security, and alignment. One governance framework, COBIT, will be utilized as a…

  2. The school governance study

    OpenAIRE

    Balarin, Maria; Brammer, Stephen; James, Chris; Mccormack, Mark

    2008-01-01

    Over the past 20 years, the English school system has changed substantially and the work of schools is now more complicated and demanding. These changes have important implications for school governing and are likely to further complicate the management of schools in the future. A study of school governing is therefore timely and appropriate.

  3. Partnerships and Governance

    DEFF Research Database (Denmark)

    Damgaard, Bodil

    Three models of cooperation are outlined and their consequences for governance discussed, using case studies of local multisectoral collaboration on labour market related social policy - active social policy - in Denmark.......Three models of cooperation are outlined and their consequences for governance discussed, using case studies of local multisectoral collaboration on labour market related social policy - active social policy - in Denmark....

  4. The governance of adaptation

    NARCIS (Netherlands)

    Huitema, Dave; Adger, William Neil; Berkhout, Frans; Massey, Eric; Mazmanian, Daniel; Munaretto, Stefania; Plummer, Ryan; Termeer, Katrien

    2016-01-01

    The governance of climate adaptation involves the collective efforts of multiple societal actors to address problems, or to reap the benefits, associated with impacts of climate change. Governing involves the creation of institutions, rules and organizations, and the selection of normative

  5. Rede de significações: perspectiva para análise da inserção de bebês na creche The insertion of babies into a day care center analysed through a network of meanings

    Directory of Open Access Journals (Sweden)

    Katia de Souza Amorim

    2000-03-01

    's first period in a day care thus implies the emergence and creation of new meanings which are attributed to, assumed by, confronted to and negotiated in the interactions established by all participants. A model was developed to analyse this process based on a research project on the insertion of 26 infants (5 to 18 months old into a day care. Video recordings, observational reports, as well as interviews with mothers, caregivers and technicians were made during the babies' first year at an university day care centre. The model focus on three main personages: mother, child and caregiver and on their mutual relationships which create three interconnected fields. The mother-child field is inserted in a larger network, the family scenery. The other two, caregiver-child and mother-caregiver fields are located in the day-care scenery. Both scenarios are impregnated by a wider social-historical matrix created in complex cultural, economic and political systems. The various elements are interconnected in a semiotic network of meanings, which continuously transforms and structures human development, allowing varied paths of behavior for each individual.

  6. Commitment to Cybersecurity and Information Technology Governance: A Case Study and Leadership Model

    Science.gov (United States)

    Curtis, Scipiaruth Kendall

    2012-01-01

    The continual emergence of technologies has infiltrated government and industry business infrastructures, requiring reforming organizations and fragile network infrastructures. Emerging technologies necessitates countermeasures, commitment to cybersecurity and information technology governance for organization's survivability and sustainability.…

  7. Obesity and government.

    Science.gov (United States)

    Kahan, Scott; Zvenyach, Tracy

    2016-10-01

    Despite much effort, obesity prevalence and disease severity continues to worsen. The purpose of this review is to describe the leading government supported food and nutrition interventions and policies to prevent and address obesity in the USA. The review also summarizes obesity interventions and policies that the government plays a role in, but further development is warranted. The government's role in obesity has largely focused on interventions and policies such as national surveillance, obesity education and awareness, grant-based food subsidy programs, zoning for food access, school-based nutrition programs, dietary guidelines, nutrition labeling, and food marketing and pricing policies. The government has played a lesser role in obesity interventions and policies that provide access to evidence-based obesity care to people affected by the disease. Given the magnitude of the obesity epidemic, the government should explore multiple evidence-based interventions and policies across prevention and clinical care.

  8. Privacy and Open Government

    Directory of Open Access Journals (Sweden)

    Teresa Scassa

    2014-06-01

    Full Text Available The public-oriented goals of the open government movement promise increased transparency and accountability of governments, enhanced citizen engagement and participation, improved service delivery, economic development and the stimulation of innovation. In part, these goals are to be achieved by making more and more government information public in reusable formats and under open licences. This paper identifies three broad privacy challenges raised by open government. The first is how to balance privacy with transparency and accountability in the context of “public” personal information. The second challenge flows from the disruption of traditional approaches to privacy based on a collapse of the distinctions between public and private sector actors. The third challenge is that of the potential for open government data—even if anonymized—to contribute to the big data environment in which citizens and their activities are increasingly monitored and profiled.

  9. Governance, Trust and Taxes

    DEFF Research Database (Denmark)

    Weihe, Guri; Joensen, E. Juanna Schröter

    This paper examines the role of social capital (trust) vis-à-vis the propensity of a country to be a tax haven. The empirical analysis corroborates that better governed countries have a higher ceteris paribus probability to be tax havens. However, social capital counteracts the effect of governance...... quality. This effect is so strong that the partial effect of governance quality is reversed for countries with the trust index in the top quartile – making these high trust countries less likely to be tax havens – even as governance quality is increased. Thus it is crucial to consider the interaction...... between institutions and social capital, since the same governance institutions have a different impact on the tax haven propensity for countries with different social capital....

  10. Energy Efficiency Governance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The purpose of this report is to help EE practitioners, government officials and stakeholders to establish the most effective EE governance structures, given their specific country context. It also aims to provide readers with relevant and accessible information to support the development of comprehensive and effective governance mechanisms. The International Energy Agency (IEA) conducted a global review of many elements of EE governance,including legal frameworks, institutional frameworks, funding mechanisms, co-ordination mechanisms and accountability arrangements, such as evaluation and oversight. The research tools included a survey of over 500 EE experts in 110 countries, follow-up interviews of over 120 experts in 27 countries and extensive desk study and literature searches on good EE governance.

  11. A new corporate governance

    Directory of Open Access Journals (Sweden)

    Ion Bucur

    2015-12-01

    Full Text Available The issue of corporate governance has become increasingly important as globalisation has begun to accelerate and the economic and financial turmoil have intensified. Post-crisis context has imposed the need to expand the prospects for analysis over governance and companies, as well as the need to identify new ways of administration and resource management. From this perspective, the author aims to highlight the conditions, factors and events that have generated profound changes within the business environment, while the analysis is focusing on contemporary changes in the systems of corporate governance and economic mutations, especially in terms of the companies. The establishment of new governance rules is demanding a theoretical approach based on new methodological requirements which are needed to reform theoretical foundations and to promote creative and effective shapes and governance systems.

  12. 'Governance' sebagai Pengelolaan Konflik

    Directory of Open Access Journals (Sweden)

    Riza Noer Arfani

    2005-03-01

    Full Text Available The article explores the notion of understanding governance as part of conflict management, or vice versa, of undustanding conflict management aspects as benefiting from governance concepts and practices. Governance, with its much broader meaning than government, suggests diverse relevant and significant clues, hints and ideas in the context of conflict management endeavors. one of which is the idea to involve larger audiences and stakeholders –beyond the conventional institutions such as governmental bodies– in policy making processes and public discourses. Such comprehension and appreciation of governance concepts and practices is certainly parallel with the conflict management philosophies, concepis and practices which based on and oriented toward integrative, non-formal and non-litigative mechanisms.

  13. Governance of the future

    DEFF Research Database (Denmark)

    Galløe, Lotte Rannveig

    as the child’s best teacher”. The program involves parents as facilitators modifying the child’s behavior instead of working directly on the child, thereby widening the target of intervention. PMTO exemplifies an arrangement that engages the private sphere in the conduct of public governance aiming at creating......In my presentation I will explore the concept, ‘technology of the future’, in public governance. Public governance within social services aims at changing the existing conditions for the marginalized citizens including children with special needs. I pose the question: what happens if public...... governance seek to chance the possible future conditions and targets the marginalized child’s relatives? Parent Management Training (PMTO) is studied as a technology of the future that expands and transforms governance. PMTO targets parents with aggressive and asocial children and aims to “create the parent...

  14. Physics and Government

    Energy Technology Data Exchange (ETDEWEB)

    Hendry, Nancy H.

    1999-08-24

    In defining the powers and duties of the three branches of government, the U.S. Constitution never explicitly referred to Science, except in the patent clause. But many technical responsibilities are implied in references to weights and measures, the census, and the like. Thomas Jefferson, John Adams, and in particular Benjamin Franklin, were highly literate in science, but it was their disciple, President John Quincy Adams who promoted as a matter of policy a direct role of the government in science--in particular with respect to astronomy, land surveys and navigation--all physical sciences. Some agencies of government--notably the National Bureau of Standards and the Department of Agriculture were founded in the early days of the Republic with scientific and technical missions. Since then the involvement of the government with science has waxed and waned but the major expansion of the interaction between physics and government occurred after World War II when physicists demonstrated the power of their craft during mobilization of science in support of the war effort. In discussing the interaction of physics with government we should distinguish ''science in government''--scientific input into policy making--from ''government in science,'' which is the support and management of that part of the overall scientific endeavor for which the government has responsibility. Let me turn first to the subject of physics in government. An overwhelming fraction of governmental decisions today have scientific and technical components; decisions ignoring these components are wasteful at best and can imperil the nation. For this reason governmental bodies at all levels solicit scientific advice--or at least give lip service to the need for such advice. When such advice was deliberately avoided, as President Reagan did before announcing his Strategic Defense Initiative in March 1983, the technically unattainable goal ''to make

  15. Understanding telecommunications networks

    CERN Document Server

    Valdar, Andy

    2017-01-01

    A telecommunications network is an electronic system of links, nodes and the controls that govern their operations to allow voice and data transfer among users and devices. This fully revised, updated and expanded second edition covers all aspects of today's networks, including how they are planned, formed and operated.

  16. The feasibility of government partnerships with NGOs in the reproductive health field in Mexico.

    Science.gov (United States)

    Gómez-Jauregui, Jesica

    2004-11-01

    In 1995 the Mexican government began to develop policies on establishing collaborative agreements with civil society organisations, and there is currently interest in Mexico in government and NGOs working together. This paper analyses whether the conditions exist in Mexico for successful partnerships between the public sector and NGOs in the reproductive health field. In-depth interviews were carried out with key informants in the public sector at national and state level and the NGO sector in six states in Mexico. Partnerships were found to be an option for the provision of reproductive health services in geographical areas where the population is under-served, and for services the government does not provide. While the contribution of NGOs to the reproductive health field is recognised, at least at federal level, there are still very few public agencies that collaborate with NGOs, and agreements are often limited to short-term financing of projects. The future of NGOs in Mexico will depend largely on their ability to obtain funding from within the country. More effective mechanisms are needed by government to generate resources for health care. Government must recognise the specific contribution of NGOs, including inputs of social capital and creation of community networks, and must share decision-making more equitably with NGO for partnerships to succeed.

  17. Governing Forest Landscape Restoration: Cases from Indonesia

    Directory of Open Access Journals (Sweden)

    Cora van Oosten

    2014-05-01

    Full Text Available Forest landscape restoration includes both the planning and implementation of measures to restore degraded forests within the perspective of the wider landscape. Governing forest landscape restoration requires fundamental considerations about the conceptualisation of forested landscapes and the types of restoration measures to be taken, and about who should be engaged in the governance process. A variety of governance approaches to forest landscape restoration exist, differing in both the nature of the object to be governed and the mode of governance. This paper analyses the nature and governance of restoration in three cases of forest landscape restoration in Indonesia. In each of these cases, both the original aim for restoration and the initiators of the process differ. The cases also differ in how deeply embedded they are in formal spatial planning mechanisms at the various political scales. Nonetheless, the cases show similar trends. All cases show a dynamic process of mobilising the landscape’s stakeholders, plus a flexible process of crafting institutional space for conflict management, negotiation and decision making at the landscape level. As a result, the landscape focus changed over time from reserved forests to forested mosaic lands. The cases illustrate that the governance of forest landscape restoration should not be based on strict design criteria, but rather on a flexible governance approach that stimulates the creation of novel public-private institutional arrangements at the landscape level.

  18. Distributed power generation impact on power distribution networks - Current status and recommended proposals; Impact de la production decentralisee sur les reseaux de distribution. Analyse de la situation et proposition de solutions

    Energy Technology Data Exchange (ETDEWEB)

    Nibbio, N.; Chollet, Ph. [Romande Energie, Morges (Switzerland); Kneuss, A.; Sauvain, H. [EIA-FR, Fribourg (Switzerland)

    2010-07-01

    This article takes a look at the new situation created in the power distribution network of a Swiss electricity utility by increasing numbers of distributed power generators, especially from renewable energy sources. To limit energy losses and maintain the grid stability, in particular the voltage within the required range, data have to be continuously collected from remote locations in the network and transmitted to a control centre that take actions. One main possible action is the injection of reactive power by means of large capacitors. The article describes a case study considering one particular section of the company's network and a 5 MW wind park.

  19. Theoretical interpretation of e-government implementation challenges in South Africa: A case study of a selected provincial government

    Directory of Open Access Journals (Sweden)

    Michael Twum-Darko

    2015-04-01

    Full Text Available This paper discusses factors influencing e-Government initiatives by African Governments to improve services to their citizens, businesses and their constituent. It further discusses, as a socially constructed phenomenon, the degree of readiness of governments to implement e-Government initiatives to improve services. The discussion uses Actor Network Theory (ANT and in particular the concepts of moments of translation and irreversibility as a lens through which to understand and interpret the social phenomenon. Although a number of e-Government researchers have argued that strong leadership and clear vision is required to implement e-Government initiatives, the view is that Governments have continuously failed to achieve the intended results. E-Government potentials and benefits which are well documented in Information Systems and e-Government research literature have not been realised by governments due to limited capabilities in the administration of the public service. The study applied a deductive approach where semi-structured interviews were used for data collection in a selected Provincial Government in South Africa. The outcome is a general framework to determine the readiness of South Africa government and generally, African governments for e-Government initiatives to achieve the intended results.

  20. Open government: collaboration, transparency, and participation in practice

    National Research Council Canada - National Science Library

    Lathrop, Daniel; Ruma, Laurel

    2010-01-01

    ... 7: Lead by Example Practical Steps for Government Agencies About the Author BY THE PEOPLE by Carl Malamud About the Author THE SINGLE POINT OF FAILURE by Beth Simone Noveck The Closed Model of Decision Making New Technologies and Civic Life Participatory Democratic Theory in the Age of Networks About the Author ENGINEERING GOOD GOVERNMENT by Ho...