WorldWideScience

Sample records for gold standard equipment

  1. ['Gold standard', not 'golden standard'

    NARCIS (Netherlands)

    Claassen, J.A.H.R.

    2005-01-01

    In medical literature, both 'gold standard' and 'golden standard' are employed to describe a reference test used for comparison with a novel method. The term 'gold standard' in its current sense in medical research was coined by Rudd in 1979, in reference to the monetary gold standard. In the same

  2. The Gold Standard Programme

    DEFF Research Database (Denmark)

    Neumann, Tim; Rasmussen, Mette; Ghith, Nermin

    2013-01-01

    To evaluate the real-life effect of an evidence-based Gold Standard Programme (GSP) for smoking cessation interventions in disadvantaged patients and to identify modifiable factors that consistently produce the highest abstinence rates.......To evaluate the real-life effect of an evidence-based Gold Standard Programme (GSP) for smoking cessation interventions in disadvantaged patients and to identify modifiable factors that consistently produce the highest abstinence rates....

  3. Equipment standards for interventional cardiology

    International Nuclear Information System (INIS)

    Dowling, A.; Gallagher, A.; Walsh, C.; Malone, J.

    2005-01-01

    Interventional radiology has seen rapid growth in cardiology and represents an alternative to hazardous surgery. Recently there has been a substantial growth in the number of procedures being performed and interventional cardiology (IC) procedures are the most common interventional procedures in Europe. Advances in imaging technology have facilitated the development of increasingly complex radiological IC equipment. Currently, the technology is developing at a rate ahead of supporting research, equipment standards and a regulatory framework. International standards play a key role in the design, manufacture and performance of radiological IC equipment. A survey of 12 IC systems (15 imaging chains) was conducted in Irish hospitals. The aim of the study was to assess the imbalance between rapidly advancing technology and existing standards and to propose recommendations for new IC equipment standards. The results demonstrate the need for definitive equipment requirements and standardisation in the design, manufacture, acceptance and maintenance of IC equipment. (authors)

  4. Electronic detecting equipment in the Camac standard

    International Nuclear Information System (INIS)

    Basiladze, S.G.

    1981-01-01

    Basic tends of development of electron detecting equipment of modern facilities for experiments in nuclear physics are considered. Special attention is paid to developments of specialized hybrid integrated circuits, specialized processors for selection of events, usage of integrated circuits of memories in detecting units as well as to prospects of developing nuclear electronics standards [ru

  5. Paper Money but a Gold Debt. Italy in the Gold Standard

    OpenAIRE

    Giuseppe Tattara; or consequences)

    2002-01-01

    During the 52 years between the Unification of the Kingdom of Italy and World War 1, the lira was legally convertible into metal for a limited period of time. Although not formally committed to gold, the lira exchange towards the gold standard countries proved remarkably stable, \\223shadowing\\224 gold. It is widely claimed that being one of the successful members of the gold standard circle entailed a number of advantages. If the lira was closely linked to gold, suggesting that there was only...

  6. Establishment of gold-quartz standard GQS-1

    Science.gov (United States)

    Millard, Hugh T.; Marinenko, John; McLane, John E.

    1969-01-01

    A homogeneous gold-quartz standard, GQS-1, was prepared from a heterogeneous gold-bearing quartz by chemical treatment. The concentration of gold in GQS-1 was determined by both instrumental neutron activation analysis and radioisotope dilution analysis to be 2.61?0.10 parts per million. Analysis of 10 samples of the standard by both instrumental neutron activation analysis and radioisotope dilution analysis failed to reveal heterogeneity within the standard. The precision of the analytical methods, expressed as standard error, was approximately 0.1 part per million. The analytical data were also used to estimate the average size of gold particles. The chemical treatment apparently reduced the average diameter of the gold particles by at least an order of magnitude and increased the concentration of gold grains by a factor of at least 4,000.

  7. Advocacy: Making the Gold Standard School a Reality

    Science.gov (United States)

    Roberts, Julia Link; Inman, Tracy Ford

    2011-01-01

    In their last column, the authors described a Gold Standard School--a place in which all children thrive including the gifted and talented. The Checklist for a Gold Standard School, which is included in this article, highlights the main characteristics of such a school including a focus on continuous progress, talent development, policies that…

  8. 48 CFR 908.7112 - Materials handling equipment replacement standards.

    Science.gov (United States)

    2010-10-01

    ... equipment replacement standards. 908.7112 Section 908.7112 Federal Acquisition Regulations System DEPARTMENT... Special Items 908.7112 Materials handling equipment replacement standards. Materials handling equipment shall be purchased for replacement purposes in accordance with the standards in FPMR 41 CFR 101-25.405...

  9. 40 CFR 63.1363 - Standards for equipment leaks.

    Science.gov (United States)

    2010-07-01

    ... the replacement equipment and the actual date of delivery of the replacement equipment. (E) The date... heavy liquid service. Information, data, and analysis used to determine that a piece of equipment or... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Standards for equipment leaks. 63.1363...

  10. 40 CFR 63.769 - Equipment leak standards.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Equipment leak standards. 63.769... § 63.769 Equipment leak standards. (a) This section applies to equipment subject to this subpart and... release to detect leaks, except under the following conditions. (i) The owner or operator has obtained...

  11. 40 CFR 63.424 - Standards: Equipment leaks.

    Science.gov (United States)

    2010-07-01

    ....424 Standards: Equipment leaks. (a) Each owner or operator of a bulk gasoline terminal or pipeline... location of all equipment in gasoline service at the facility. (c) Each detection of a liquid or vapor leak... replacement of leaking equipment shall be completed within 15 calendar days after detection of each leak...

  12. 40 CFR 63.648 - Equipment leak standards.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Equipment leak standards. 63.648...) National Emission Standards for Hazardous Air Pollutants From Petroleum Refineries § 63.648 Equipment leak...) through (c)(10) and (e) through (i) of this section. (1) The instrument readings that define a leak for...

  13. Russian seismic standards and demands for equipment and their conformity with international standards

    International Nuclear Information System (INIS)

    Kaznovsky, S.; Ostretsov, I.

    1993-01-01

    The principle regulations of standard documents concerning seismic safety of NPPs and demands for reactor equipment conformity with international standards are presented in this report. General state of NPP safety standards is reviewed, with a special emphasis on the state of seismic design standards for NPP equipment and piping. Russian standards documents on seismic resistance of NPPs and requirements are compared to international ones

  14. Democratic Constraints and Adherence to the Classical Gold Standard

    NARCIS (Netherlands)

    Kramer, Bert S.; Milionis, Petros

    We study how domestic politics affected the decisions of countries to adhere to the classical gold standard. Using a variety of econometric techniques and controlling for a wide range of economic factors, we demonstrate that political constraints were important in the decision of countries to adopt

  15. The Trouble with the Gold Standard: School Libraries & Research

    Science.gov (United States)

    Gordon, Carol

    2007-01-01

    Although science has provided empirical evidence for centuries, it's only as recently as the 1940s that a scientific method called randomized controlled trials (RCT) emerged as a technique to test the efficacy of drugs and medical procedures. Since RCT is unique in that it can claim causality, it's considered the "gold standard" of research…

  16. Imperfect Gold Standards for Kidney Injury Biomarker Evaluation

    Science.gov (United States)

    Betensky, Rebecca A.; Emerson, Sarah C.; Bonventre, Joseph V.

    2012-01-01

    Clinicians have used serum creatinine in diagnostic testing for acute kidney injury for decades, despite its imperfect sensitivity and specificity. Novel tubular injury biomarkers may revolutionize the diagnosis of acute kidney injury; however, even if a novel tubular injury biomarker is 100% sensitive and 100% specific, it may appear inaccurate when using serum creatinine as the gold standard. Acute kidney injury, as defined by serum creatinine, may not reflect tubular injury, and the absence of changes in serum creatinine does not assure the absence of tubular injury. In general, the apparent diagnostic performance of a biomarker depends not only on its ability to detect injury, but also on disease prevalence and the sensitivity and specificity of the imperfect gold standard. Assuming that, at a certain cutoff value, serum creatinine is 80% sensitive and 90% specific and disease prevalence is 10%, a new perfect biomarker with a true 100% sensitivity may seem to have only 47% sensitivity compared with serum creatinine as the gold standard. Minimizing misclassification by using more strict criteria to diagnose acute kidney injury will reduce the error when evaluating the performance of a biomarker under investigation. Apparent diagnostic errors using a new biomarker may be a reflection of errors in the imperfect gold standard itself, rather than poor performance of the biomarker. The results of this study suggest that small changes in serum creatinine alone should not be used to define acute kidney injury in biomarker or interventional studies. PMID:22021710

  17. Studies and research concerning BNFP: cask handling equipment standardization

    International Nuclear Information System (INIS)

    McCreery, P.N.

    1980-10-01

    This report covers the activities of one of the sub-tasks within the Spent LWR Fuel Transportation Receiving, Handling, and Storage program. The sub-task is identified as Cask Handling Equipment Standardization. The objective of the sub-task specifies: investigate and identify opportunities for standardization of cask interface equipment. This study will examine the potential benefits of standardized yokes, decontamination barriers and special tools, and, to the extent feasible, standardized methods and software for handling the variety of casks presently available in the US fleet. The result of the investigations is a compilation of reports that are related by their common goal of reducing cask turnaround time

  18. Use of commercial grade equipment and industrial standards for equipment qualification

    International Nuclear Information System (INIS)

    Gradin, L.P.; Muller, E.S.

    1984-01-01

    One of the most controversial issues is the proper application of Arrhenius aging methodology. Naturally and artificially aged equipment used in type test programs are often costly and burdensome tasks. Appropriate use of non-nuclear industrial standards and comparison to past history can demonstrate, with reasonable assurance, that equipment is qualified with proper consideration of aging. Specific review of the industrial standards available and application examples are provided

  19. Postcholecystectomy benign biliary stricture: Surgery is the gold standard

    Directory of Open Access Journals (Sweden)

    Sadiq S Sikora

    2012-01-01

    Full Text Available Post cholecystectomy bile duct strictures present a challenge to the treating physicians. Advancement in skills and technology offers alternative treatment modalities to the standard surgical repair. Contemporary series of surgical repair by experienced surgeons report excellent long-term results with <5% restricture rates. Endoscopic therapy is conceptually flawed, is not applicable to all patients, requires prolonged duration of treatment with multiple interventions. Surgical repair by an experienced surgeon is the "Gold Standard" of care in management of postcholecystectomy bile duct strictures.

  20. The gold standard: gold nanoparticle libraries to understand the nano-bio interface.

    Science.gov (United States)

    Alkilany, Alaaldin M; Lohse, Samuel E; Murphy, Catherine J

    2013-03-19

    Since the late 1980s, researchers have prepared inorganic nanoparticles of many types--including elemental metals, metal oxides, metal sulfides, metal selenides, and metal tellurides--with excellent control over size and shape. Originally many researchers were primarily interested in exploring the quantum size effects predicted for such materials. Applications of inorganic nanomaterials initially centered on physics, optics, and engineering but have expanded to include biology. Many current nanomaterials can serve as biochemical sensors, contrast agents in cellular or tissue imaging, drug delivery vehicles, or even as therapeutics. In this Account we emphasize that the understanding of how nanomaterials will function in a biological system relies on the knowledge of the interface between biological systems and nanomaterials, the nano-bio interface. Gold nanoparticles can serve as excellent standards to understand more general features of the nano-bio interface because of its many advantages over other inorganic materials. The bulk material is chemically inert, and well-established synthetic methods allow researchers to control its size, shape, and surface chemistry. Gold's background concentration in biological systems is low, which makes it relatively easy to measure it at the part-per-billion level or lower in water. In addition, the large electron density of gold enables relatively simple electron microscopic experiments to localize it within thin sections of cells or tissue. Finally, gold's brilliant optical properties at the nanoscale are tunable with size, shape, and aggregation state and enable many of the promising chemical sensing, imaging, and therapeutic applications. Basic experiments with gold nanoparticles and cells include measuring the toxicity of the particles to cells in in vitro experiments. The species other than gold in the nanoparticle solution can be responsible for the apparent toxicity at a particular dose. Once the identity of the toxic

  1. How the Gold Standard Functioned in Portugal: An Analysis of Some Macroeconomic Aspects

    OpenAIRE

    António Portugal Duarte; João Sousa Andrade

    2011-01-01

    The purpose of this study is to improve understanding of the gold standard period in Portugal through comparison with other monetary systems that were operated afterwards. Portugal was the first country in Europe to join Great Britain in the gold standard, in 1854, and it adhered to it for quite a long time. The principle of free gold convertibility of the Portuguese currency at a fixed price was abandoned in 1891, even though the classical gold standard as an international monetary system ...

  2. Standardized methods for photography in procedural dermatology using simple equipment.

    Science.gov (United States)

    Hexsel, Doris; Hexsel, Camile L; Dal'Forno, Taciana; Schilling de Souza, Juliana; Silva, Aline F; Siega, Carolina

    2017-04-01

    Photography is an important tool in dermatology. Reproducing the settings of before photos after interventions allows more accurate evaluation of treatment outcomes. In this article, we describe standardized methods and tips to obtain photographs, both for clinical practice and research procedural dermatology, using common equipment. Standards for the studio, cameras, photographer, patients, and framing are presented in this article. © 2017 The International Society of Dermatology.

  3. Gold-standard for computer-assisted morphological sperm analysis.

    Science.gov (United States)

    Chang, Violeta; Garcia, Alejandra; Hitschfeld, Nancy; Härtel, Steffen

    2017-04-01

    Published algorithms for classification of human sperm heads are based on relatively small image databases that are not open to the public, and thus no direct comparison is available for competing methods. We describe a gold-standard for morphological sperm analysis (SCIAN-MorphoSpermGS), a dataset of sperm head images with expert-classification labels in one of the following classes: normal, tapered, pyriform, small or amorphous. This gold-standard is for evaluating and comparing known techniques and future improvements to present approaches for classification of human sperm heads for semen analysis. Although this paper does not provide a computational tool for morphological sperm analysis, we present a set of experiments for comparing sperm head description and classification common techniques. This classification base-line is aimed to be used as a reference for future improvements to present approaches for human sperm head classification. The gold-standard provides a label for each sperm head, which is achieved by majority voting among experts. The classification base-line compares four supervised learning methods (1- Nearest Neighbor, naive Bayes, decision trees and Support Vector Machine (SVM)) and three shape-based descriptors (Hu moments, Zernike moments and Fourier descriptors), reporting the accuracy and the true positive rate for each experiment. We used Fleiss' Kappa Coefficient to evaluate the inter-expert agreement and Fisher's exact test for inter-expert variability and statistical significant differences between descriptors and learning techniques. Our results confirm the high degree of inter-expert variability in the morphological sperm analysis. Regarding the classification base line, we show that none of the standard descriptors or classification approaches is best suitable for tackling the problem of sperm head classification. We discovered that the correct classification rate was highly variable when trying to discriminate among non-normal sperm

  4. Standard guide for hot cell specialized support equipment and tools

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 Intent: 1.1.1 This guide presents practices and guidelines for the design and implementation of equipment and tools to assist assembly, disassembly, alignment, fastening, maintenance, or general handling of equipment in a hot cell. Operating in a remote hot cell environment significantly increases the difficulty and time required to perform a task compared to completing a similar task directly by hand. Successful specialized support equipment and tools minimize the required effort, reduce risks, and increase operating efficiencies. 1.2 Applicability: 1.2.1 This guide may apply to the design of specialized support equipment and tools anywhere it is remotely operated, maintained, and viewed through shielding windows or by other remote viewing systems. 1.2.2 Consideration should be given to the need for specialized support equipment and tools early in the design process. 1.2.3 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conv...

  5. From silver currency to the gold standard in the Philippine Islands

    NARCIS (Netherlands)

    Wolters, W.G.

    2003-01-01

    In 1903, the United States government introduced a gold standard monetary system in the Philippines, with a theoretical gold peso and a token silver peso in circulation. This currency reform was part of a wider American diplomatic offensive to expand the sphere of gold-based currencies in the world,

  6. DCU 250 Arabic dependency bank: an LFG gold standard resource for the Arabic Penn treebank

    OpenAIRE

    Al-Raheb, Yafa; Akrout, Amine; van Genabith, Josef; Dichy, J.

    2006-01-01

    This paper describes the construction of a dependency bank gold standard for Arabic, DCU 250 Arabic Dependency Bank (DCU 250), based on the Arabic Penn Treebank Corpus (ATB) (Bies and Maamouri, 2003; Maamouri and Bies, 2004) within the theoretical framework of Lexical Functional Grammar (LFG). For parsing and automatically extracting grammatical and lexical resources from treebanks, it is necessary to evaluate against established gold standard resources. Gold standards for various languages h...

  7. The gold standard and the European Monetary Union (EMU) : are the factors that contributed to the breakdown of the gold standard also present in the EMU?

    OpenAIRE

    Wergeland, Helene

    2012-01-01

    This thesis seeks to identify the most important factors that contributed to the breakdown of the gold standard in the 1930s, and to see if these factors are present in the European Monetary Union (EMU) today. This is done in order to find out if the same factors might create, or have created, similar instabilities and problems in the EMU as they imposed on the interwar gold standard. The factors regarded as important for the breakdown of the gold standard are (1) the central ...

  8. Median sternotomy - gold standard incision for cardiac surgeons

    Directory of Open Access Journals (Sweden)

    Radu Matache

    2016-05-01

    Full Text Available Sternotomy is the gold standard incision for cardiac surgeons but it is also used in thoracic surgery especially for mediastinal, tracheal and main stem bronchus surgery. The surgical technique is well established and identification of the correct anatomic landmarks, midline tissue preparation, osteotomy and bleeding control are important steps of the procedure. Correct sternal closure is vital for avoiding short- and long-term morbidity and mortality. The two sternal halves have to be well approximated to facilitate healing of the bone and to avoid instability, which is a risk factor for wound infection. New suture materials and techniques would be expected to be developed to further improve the patients evolution, in respect to both immediate postoperative period and long-term morbidity and mortality

  9. Building gold standard corpora for medical natural language processing tasks.

    Science.gov (United States)

    Deleger, Louise; Li, Qi; Lingren, Todd; Kaiser, Megan; Molnar, Katalin; Stoutenborough, Laura; Kouril, Michal; Marsolo, Keith; Solti, Imre

    2012-01-01

    We present the construction of three annotated corpora to serve as gold standards for medical natural language processing (NLP) tasks. Clinical notes from the medical record, clinical trial announcements, and FDA drug labels are annotated. We report high inter-annotator agreements (overall F-measures between 0.8467 and 0.9176) for the annotation of Personal Health Information (PHI) elements for a de-identification task and of medications, diseases/disorders, and signs/symptoms for information extraction (IE) task. The annotated corpora of clinical trials and FDA labels will be publicly released and to facilitate translational NLP tasks that require cross-corpora interoperability (e.g. clinical trial eligibility screening) their annotation schemas are aligned with a large scale, NIH-funded clinical text annotation project.

  10. Belling the cat: Eli F. Heckscher on the gold standard as a discipline device

    OpenAIRE

    Fregert, Klas

    2013-01-01

    Unlike Knut Wicksell, Eli Heckscher did not believe the time had arrived for “managed money” to replace the gold standard after World War I. The war had shown that only a gold standard could bind the central bank to a time-consistent policy with reasonable price stability. Heckscher likened the problem of reinstating the gold standard to “Belling the cat” in Aesop’s fable. When the international gold standard crumbled in the Great Depression, he supported the Swedish price stabilization regim...

  11. Energy efficiency standards for residential and commercial equipment: Additional opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Rosenquist, Greg; McNeil, Michael; Iyer, Maithili; Meyers, Steve; McMahon, Jim

    2004-08-02

    , it is either impossible or more costly to improve the energy efficiency. Therefore, by not expanding or upgrading energy efficiency standards, opportunities for saving energy would be lost. In the past two decades, standards have significantly raised the level of energy efficiency for new products. How much more might be gained by making standards more stringent on products already subject to them, or by extending standards to products not yet covered? The main goal of this study is to estimate key national impacts of new and upgraded energy efficiency standards for residential and commercial equipment. These impacts approximate the opportunity for national benefits that may be lost if standards are not upgraded and expanded from current levels. This study also identifies the end uses where the largest opportunities exist. This analysis was prepared for the National Commission on Energy Policy (NCEP). It uses an analytical approach that is similar in concept to that used by the U.S. Department of Energy (DOE) to set standard levels. It relies on much less data and uses more simplified assumptions than the detailed and complex formulations used in DOE's standard-setting process. The results of this analysis should thus be viewed as a first approximation of the impacts that would actually be achieved by new standards. All monetary values in this report are in 2002 dollars.

  12. Evaluation of 2 new optical biometry devices and comparison with the current gold standard biometer.

    Science.gov (United States)

    Chen, Yen-An; Hirnschall, Nino; Findl, Oliver

    2011-03-01

    To compare 2 new optical biometry devices with the present gold standard biometer. Vienna Institute for Research in Ocular Surgery, Department of Ophthalmology, Hanusch Hospital, Vienna, Austria. Evaluation of diagnostic test or technology. In patients scheduled for cataract surgery, measurements performed with the current gold standard optical biometer (IOLMaster) were compared with those of 2 new optical biometers, the Lenstar LS 900 (optical low-coherence reflectometry [OLCR] device; substudy 1) and the IOLMaster 500 (partial coherence interferometry [PCI] device; substudy 2). The duration of patient data entry and of the actual measurement process and the time from intraocular lens power calculation to printout were calculated. The mean difference in axial length measurements was 0.01 mm ± 0.05 (SD) between the gold standard device and the new OLCR device and 0.01 ± 0.02 mm between the gold standard device and the new PCI device (P=.12 and P gold standard device (mean difference 209 ± 127 seconds), and measurements with the gold standard device took significantly longer than with the new PCI device (mean difference 82 ± 46 seconds) (both P gold standard device. Measurements with the new OLCR device took twice as long as those with the gold standard device. Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  13. Towards a systematic format for (seismic) equipment qualification standards

    International Nuclear Information System (INIS)

    Smith, P.D.

    1982-01-01

    As part of technical assistance to the US Nuclear Regulatory Commission (NRC, 1), a systematic format for seismic equipment qualification (EQ) was initiated. This format consists of thirty issues associated with seismic EQ. Each issue was considered as a Category of Possible Seismic EQ Requirements and Criteria. That is, seismic EQ standards might be (but presently are not formulated in terms of requirements and criteria that address each of the thirty issues. Each of the thirty issues was ranked and a minimum set identified. The current requirements in existing NRC and national standards were also evaluated against this common set of issues, and they were estimated to score 60 out of 100 overall. It is believed that the systematic format exhibited in this paper can be of assistance in obtaining a broader and more complete perspective on seismic EQ issues. This format (but especially the technique) may also be of interest in non-seismic EQ since many of the issues are common

  14. Annotated chemical patent corpus: a gold standard for text mining.

    Directory of Open Access Journals (Sweden)

    Saber A Akhondi

    Full Text Available Exploring the chemical and biological space covered by patent applications is crucial in early-stage medicinal chemistry activities. Patent analysis can provide understanding of compound prior art, novelty checking, validation of biological assays, and identification of new starting points for chemical exploration. Extracting chemical and biological entities from patents through manual extraction by expert curators can take substantial amount of time and resources. Text mining methods can help to ease this process. To validate the performance of such methods, a manually annotated patent corpus is essential. In this study we have produced a large gold standard chemical patent corpus. We developed annotation guidelines and selected 200 full patents from the World Intellectual Property Organization, United States Patent and Trademark Office, and European Patent Office. The patents were pre-annotated automatically and made available to four independent annotator groups each consisting of two to ten annotators. The annotators marked chemicals in different subclasses, diseases, targets, and modes of action. Spelling mistakes and spurious line break due to optical character recognition errors were also annotated. A subset of 47 patents was annotated by at least three annotator groups, from which harmonized annotations and inter-annotator agreement scores were derived. One group annotated the full set. The patent corpus includes 400,125 annotations for the full set and 36,537 annotations for the harmonized set. All patents and annotated entities are publicly available at www.biosemantics.org.

  15. Outpatient laparoscopic cholecystectomy: A new gold standard for cholecystectomy?

    Directory of Open Access Journals (Sweden)

    J. Bueno Lledó

    Full Text Available Objective: to contribute our experience for five years in the implemetation of outpatient laparoscopic cholecystectomy (LC. Patients: between January 1999 and March 2004 we performed 504 outpatient LCs. We applied both exclusion and inclusion criteria, an anesthetic and surgical protocol, and discharge-specific criteria. Postoperative management in "fast track" regime. Postoperative period controlled by protocol, including phone calls after cholecystectomy. Results: the ambulatory percentage in the global series was 88.8%, and mean hospital stay was 6.1 hours. Fifty-one patients required overnight stays (10.1%, most of them for "social" causes. Five patients required admission (between 24 and 48 hours for different causes (conversion to laparotomy, intraoperative neumothorax, and postoperative medical complications. Six patients (1.1% were readmitted, and we observed 11.6% postoperative complications in the global series, with abdominal parietal pain being most frequent. Phone localization by 22.00 p.m. in the same day of surgery was 100% complete for outpatient cases. Postoperative surveillance within the first month after surgery was completed in 93.9%, and within th first year in 86.7% of patients. Conclusions: outpatient LC is safe and feasible, and probably represents a new "gold standard" in the treatment of symptomatic cholelithiasis.

  16. Imatinib mesylate--gold standards and silver linings.

    Science.gov (United States)

    Peggs, K

    2004-09-01

    Imatinib mesylate represents the first of a new generation of molecularly targeted therapies engineered to disrupt signal transduction pathways. It is a tyrosine kinase inhibitor with relatively selective activity against the Abelson (ABL) proto-oncogene, platelet-derived growth factor receptor, and c-KIT receptor. Deregulated tyrosine kinase activity has been implicated as a central pathogenic event in a number of human malignancies, most notably chronic myeloid leukemia. In this myeloproliferative disorder the t(9;22) reciprocal translocation results in the generation of a novel fusion oncoprotein, BCR-ABL, with constitutive tyrosine kinase activity. Imatinib inhibits this activity, inducing remarkable rates of hematological and cytogenetic remission in excess of those seen with alternative medical therapies. Following a large phase III study comparing its efficacy with the combination of interferon alpha and low-dose cytarabine, it has emerged as the current gold standard therapy for patients with chronic-phase disease without a potential bone marrow donor and those considered unsuitable for bone marrow transplantation. Its integration into the management of those patients who might be considered for transplantation, which has historically been considered the only potentially curative approach, remains a major challenge. The increasing recognition and subsequent molecular characterization of resistance mechanisms has reinforced the need to exercise caution against deferring a proven curative therapy in favor of a treatment approach that is still investigational, with the spectre of increased numbers of patients progressing to sudden-onset blast crisis remaining the potential dark cloud in the silver lining for imatinib.

  17. 41 CFR 109-38.5104 - Other motor equipment utilization standards.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Other motor equipment... AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 38-MOTOR EQUIPMENT MANAGEMENT 38.51-Utilization of Motor Equipment § 109-38.5104 Other motor equipment utilization standards. No utilization standards are...

  18. Standardization and improvement of safety for radioisotope equipped instruments

    International Nuclear Information System (INIS)

    Sumi, Tetsuo

    1980-01-01

    The safety for radioisotope-equipped instruments is considered. The one is the safety for the source assembly. The radioisotopes employed for radioisotope-equipped instruments are sealed sources which are used in the state of being contained in the enclosures. Many of the enclosures are provided with shutter mechanism for the purpose of emitting radiation only during the period required. If the possible troubles that might lead to the accidents are sampled out of the results of field operation of radiation instruments, and the safety measures for source enclosures are considered in connection with these troubles, it is no exaggeration to say that the safety for source enclosures has been maintained by preventing the critical accidents by the management of users and the cooperation of manufactures though there were the chance for investigating the safety in the common field and the establishment of JIS Z 4614 standard. Another consideration is concerned with the measures to improve the safety. No accident in the past never guarantees no accident in the future. Accumulation of experience is most effective for those measures, and the more experiences the better. It may be most effective that the manufacturers disclose their experiences each other from the wide outlook overcoming the barrier of trade secret. Fortunately, such consciousness has risen since a few years ago, and the investigation group is doing the works in the Japan Radioisotope Association. On the other hand, the reasonable revision of the radiation injury prevention law is desired. (Wakatsuki, Y.)

  19. After the Gold Rush: Questioning the "Gold Standard" and Reappraising the Status of Experiment and Randomized Controlled Trials in Education

    Science.gov (United States)

    Thomas, Gary

    2016-01-01

    The past few years have seen a resurgence of faith in experimentation in education inquiry, and particularly in randomized controlled trials (RCTs). Proponents of such research have succeeded in bringing into common parlance the term "gold standard," which suggests that research emerging from any other design frame fails to achieve the…

  20. 75 FR 28227 - National Emission Standards for Hazardous Air Pollutants: Gold Mine Ore Processing and Production...

    Science.gov (United States)

    2010-05-20

    ...-AP48 National Emission Standards for Hazardous Air Pollutants: Gold Mine Ore Processing and Production... published a proposed rule for mercury emissions from the gold mine ore processing and production area source... Environmental protection, Air pollution control, Hazardous substances, Incorporations by reference, Reporting...

  1. Strain study of gold nanomaterials as HR-TEM calibration standard.

    Science.gov (United States)

    Peng, X Y; Zhou, L Q; Li, X; Tao, X F; Ren, L L; Cao, W H; Xu, G F

    2015-12-01

    This work presents the use of high resolution electron microscopy (HREM) and geometric phase analysis (GPA) to measure the interplanar spacing and strain distribution of three gold nanomaterials, respectively. The results showed that the {111} strain was smaller than the {002} strain for any kind of gold materials at the condition of same measuring method. The 0.65% of {111} strain in gold film measured by HREM (0.26% measured by GPA) was smaller than the {111} strains in two gold particles. The presence of lattice strain was interpreted according to the growth mechanism of metallic thin film. It is deduced that the {111} interplanar spacing of the gold thin film is suitable for high magnification calibration of transmission electron microscopy (TEM) and the gold film is potential to be a new calibration standard of TEM. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Strategy for conformity of non-standard cryogenic equipment

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    CERN as an intergovernmental organization establishes its own Safety Rules as necessary for its proper functioning. In particular, the CERN General Safety Instruction for cryogenic equipment requires that cryogenic pressure equipment at CERN shall comply with the European Pressure Equipment Directive (PED). However, due to the particular features of some of the cryogenic equipment required for the accelerators, as well as the existence of international collaborations with in-kind contributions from non-EU countries, full compliance with the PED may not always be achieved. This situation is foreseen in the Safety Rules, where CERN HSE will define the Safety requirements applicable to such equipment as well as any eventual additional compensatory measure as to ensure a commensurate level of Safety for our pressure equipment. Where compliance with PED may not be achieved, CERN HSE will become the de facto Notified Body and therefore be in charge of the assessment of the conformity of the equipment to the applica...

  3. Facility-wide synchronization of standard FAIR equipment controllers

    International Nuclear Information System (INIS)

    Rauch, S.; Terpstra, W.; Panschow, W.; Thieme, M.; Prados, C.; Zweig, M.; Kreider, M.; Beck, D.; Bär, R.

    2012-01-01

    The standard equipment controller under development for the new FAIR accelerator facility is the Scalable Control Unit (SCU). It is designed to synchronize and control the actions of up to 12 purpose-built slave cards, connected in a proprietary crate by a parallel backplane. Inter-crate coordination and facility-wide synchronization are a core FAIR requirement and thus precise timing of SCU slave actions is of vital importance. The SCU consists primarily of two components, an x86 COM Express daughter board and a carrier board with an Altera Arria II GX FPGA, interconnected by PCI Express. The x86 receives configuration and set values with which it programs the real-time event-condition-action (ECA) unit in the FPGA. The ECA unit receives event messages via the timing network, which also synchronizes the clocks of all SCUs in the facility using White Rabbit. Matching events trigger actions on the SCU slave cards such as: ramping magnets, triggering kickers, etc. Timing requirements differ depending on the action taken. For softer real-time actions, an interrupt can be generated for complex processing on the x86. Alternatively, the FPGA can directly fire a pulse out a LEMO output or an immediate SCU bus operation. The delay and synchronization achievable in each case differs and this paper examines the timing performance of each to determine which approach is appropriate for the required actions. (author)

  4. Performance of the standard FAIR equipment controller prototype

    International Nuclear Information System (INIS)

    Rauch, S.; Baer, R.C.; Panschow, W.; Thieme, M.

    2012-01-01

    For the control system of the new FAIR accelerator facility a standard equipment controller, the Scalable Control Unit (SCU), is presently under development. First prototypes have already been tested in real applications. The controller combines an *86 COM Express TM Board and an Altera Arria TM II FPGA. Over a parallel bus interface called the SCU bus, up to 12 slave boards can be controlled. Communication between CPU and FPGA is done by a PCIe link. We discuss the real time behaviour between the Linux OS and the FPGA Hardware. For the test, a Front-End Software Architecture (FESA) class, running under Linux, communicates with the PCIe bridge in the FPGA. Although we are using PCIe only for single 32 bit wide accesses to the FPGA address space, the performance still seems sufficient. The tests showed an average response time to IRQs of 50 μs with a 1.6 GHz Intel Atom CPU. This includes the context change to the FESA user space application and the reply back to the FPGA. Further topics are the bandwidth of the PCIe link for single/burst transfers and the performance of the SCU bus communication. (authors)

  5. Status analysis of Chinese standards on enclosure equipment and proposed countermeasures

    International Nuclear Information System (INIS)

    Wu Luping

    1998-12-01

    Enclosure equipment, such as glove box, tong box etc., is an important kind of equipment for nuclear industry and nuclear scientific research. The status of the establishment and implementation of Chinese standards on enclosure equipment is briefly described. Some problems and deficiency existing in these standards are pointed out. The ISO standard projects on containment enclosures as well as their present progress situations are introduced. The measure for updating Chinese standards on enclosure equipment in accordance with the principle of adopting international standards are recommended. Some issues which should be taken into account in adopting ISO standards on containment enclosures are also discussed

  6. Preparing an annotated gold standard corpus to share with extramural investigators for de-identification research.

    Science.gov (United States)

    Deleger, Louise; Lingren, Todd; Ni, Yizhao; Kaiser, Megan; Stoutenborough, Laura; Marsolo, Keith; Kouril, Michal; Molnar, Katalin; Solti, Imre

    2014-08-01

    The current study aims to fill the gap in available healthcare de-identification resources by creating a new sharable dataset with realistic Protected Health Information (PHI) without reducing the value of the data for de-identification research. By releasing the annotated gold standard corpus with Data Use Agreement we would like to encourage other Computational Linguists to experiment with our data and develop new machine learning models for de-identification. This paper describes: (1) the modifications required by the Institutional Review Board before sharing the de-identification gold standard corpus; (2) our efforts to keep the PHI as realistic as possible; (3) and the tests to show the effectiveness of these efforts in preserving the value of the modified data set for machine learning model development. In a previous study we built an original de-identification gold standard corpus annotated with true Protected Health Information (PHI) from 3503 randomly selected clinical notes for the 22 most frequent clinical note types of our institution. In the current study we modified the original gold standard corpus to make it suitable for external sharing by replacing HIPAA-specified PHI with newly generated realistic PHI. Finally, we evaluated the research value of this new dataset by comparing the performance of an existing published in-house de-identification system, when trained on the new de-identification gold standard corpus, with the performance of the same system, when trained on the original corpus. We assessed the potential benefits of using the new de-identification gold standard corpus to identify PHI in the i2b2 and PhysioNet datasets that were released by other groups for de-identification research. We also measured the effectiveness of the i2b2 and PhysioNet de-identification gold standard corpora in identifying PHI in our original clinical notes. Performance of the de-identification system using the new gold standard corpus as a training set was very

  7. 40 CFR 61.135 - Standard: Equipment leaks.

    Science.gov (United States)

    2010-07-01

    ... stuffing box pressure; or (ii) Equipped with a barrier fluid system that is connected by a closed vent... system that purges the barrier fluid into a process stream with zero benzene emissions to the atmosphere...

  8. Rail Safety/Equipment Crashworthiness : Volume 3. Proposed Engineering Standards.

    Science.gov (United States)

    1978-07-01

    The document, the third of four volumes, contains recommended Engineering Standards prepared in the format of the standards published in the Code of Federal Regulations (Title 49, Transportation, Parts 200). The standards proposed provide improved oc...

  9. International Reserves Crises, Monetary Integration and the Payments System during the International Gold Standard

    OpenAIRE

    Paula Hernandez-Verme

    2009-01-01

    I model an international payments system with a financial center and periphery to reproduce various aspects of the International Gold Standard. This period was characterized by frequent crises associated with scarce stocks of reserves, high short-term interest rates with subsequent gold inflows and transmission of output contractions across countries. I find that a common international currency and no legal restrictions on exchange help the periphery share reserves with the financial center, ...

  10. Determination of gold and silver in geological standard samples MGI by instrument neutron activation analysis

    International Nuclear Information System (INIS)

    Lu Huijiuan; Zhou; Yunlu

    1987-01-01

    Gold and silver in geological standard samples MGI were determined by instrument neutron activation analysis. The various interferences of nuclides were considered. Corrected factors of the geometry in different positions have been determined. Using the geological standard sample MGM and radiochemical separation neutron activation method as reference, the reliability of this method is proved. Gold content in samples is 0.4-0.009 g/t, silver content is 9-0.3 g/t. Standard deviation is less than 3.5%, the precision of the measurement is 4.8-11.6%

  11. 40 CFR 82.158 - Standards for recycling and recovery equipment.

    Science.gov (United States)

    2010-07-01

    ... importers of recycling and recovery equipment intended for use during the maintenance, service, or repair of... recycling or recovery equipment at manufacturing facilities to ensure that each equipment model line that... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Standards for recycling and recovery...

  12. Development of a Consensus Standard for School Equipment: NSF/NSSEA 380

    Science.gov (United States)

    Breitner, Ashlee

    2011-01-01

    For many years, the school supplies and equipment industry has investigated methods to ensure product safety and compliance across all its product categories. In early 2010, NSF International and the National School Supply and Equipment Association (NSSEA) came together to develop quality standards for products and equipment designed for use in…

  13. Development of standardized component\\0x2010based equipment specifications and transition plan into a predictive maintenance strategy.

    Science.gov (United States)

    2015-12-01

    This project investigated INDOT equipment records and equipment industry standards to produce standard equipment specifications : and a predictive maintenance schedule for the more than 1100 single and tandem axle trucks in use at INDOT. The research...

  14. Development of standardized component\\0x2010based equipment specifications and transition plan into a predictive maintenance strategy : final report.

    Science.gov (United States)

    2015-12-01

    This project investigated INDOT equipment records and equipment industry standards to produce standard equipment specifications : and a predictive maintenance schedule for the more than 1100 single and tandem axle trucks in use at INDOT. The research...

  15. Non-standard equipment for construction of vertical shafts

    Science.gov (United States)

    Yagodkin, F. I.; Prokopov, A. Y.; Pleshko, M. S.; Pankratenko, A. N.

    2017-10-01

    The article deals with the modern problems of construction and reconstruction of vertical shafts of mines, which require innovative technical solutions in the mechanization of mining operations. The examples developed by the authors of the original equipment and technologies, are successfully implemented for the mining industry in Russia.

  16. A framework for automatic creation of gold-standard rigid 3D-2D registration datasets.

    Science.gov (United States)

    Madan, Hennadii; Pernuš, Franjo; Likar, Boštjan; Špiclin, Žiga

    2017-02-01

    Advanced image-guided medical procedures incorporate 2D intra-interventional information into pre-interventional 3D image and plan of the procedure through 3D/2D image registration (32R). To enter clinical use, and even for publication purposes, novel and existing 32R methods have to be rigorously validated. The performance of a 32R method can be estimated by comparing it to an accurate reference or gold standard method (usually based on fiducial markers) on the same set of images (gold standard dataset). Objective validation and comparison of methods are possible only if evaluation methodology is standardized, and the gold standard  dataset is made publicly available. Currently, very few such datasets exist and only one contains images of multiple patients acquired during a procedure. To encourage the creation of gold standard 32R datasets, we propose an automatic framework. The framework is based on rigid registration of fiducial markers. The main novelty is spatial grouping of fiducial markers on the carrier device, which enables automatic marker localization and identification across the 3D and 2D images. The proposed framework was demonstrated on clinical angiograms of 20 patients. Rigid 32R computed by the framework was more accurate than that obtained manually, with the respective target registration error below 0.027 mm compared to 0.040 mm. The framework is applicable for gold standard setup on any rigid anatomy, provided that the acquired images contain spatially grouped fiducial markers. The gold standard datasets and software will be made publicly available.

  17. Effectiveness of the Gold Standard Programme compared with other smoking cessation interventions in Denmark

    DEFF Research Database (Denmark)

    Rasmussen, Mette; Fernández, Esteve; Tønnesen, Hanne

    2017-01-01

    Objectives: We compared the effectiveness of the Gold Standard Programme (a comprehensive smoking cessation intervention commonly used in Denmark) with other face-to-face smoking cessation programmes in Denmark after implementation in real life, and we identified factors associated with successful...... did not want further contact, who intentionally were not followed up or who lacked information about the intervention they received were excluded. A total of 46 287 smokers were included. Interventions: Various real-life smoking cessation interventions were identified and compared: The Gold Standard...... smokers. The follow-up rate was 74%. Women were less likely to remain abstinent, OR 0.83 (CI 0.79 to 0.87). Short interventions were more effective among men. After adjusting for confounders, the Gold Standard Programme was the only intervention with significant results across sex, increasing the odds...

  18. MANUAL FOOD AND BEVERAGE DISPENSING EQUIPMENT. NATIONAL SANITATION FOUNDATION STANDARD NO. 18.

    Science.gov (United States)

    National Sanitation Foundation, Ann Arbor, MI.

    THIS STANDARD COVERS THE SANITATION REQUIREMENTS FOR EQUIPMENT AND DEVICES WHICH DISPENSE FOOD OR BEVERAGE EITHER IN BULK OR PORTIONS. VENDING MACHINES OR BULK MILK DISPENSING EQUIPMENT ARE NOT COVERED IN THIS STANDARD. ITEMS COVERED INCLUDE THE BASIC PRINCIPLES OF DESIGN AND CONSTRUCTION, FOOD PROTECTION AND FREEDOM FROM HARBORAGES. MINIMUM…

  19. 38 CFR 17.155 - Minimum standards of safety and quality for automotive adaptive equipment.

    Science.gov (United States)

    2010-07-01

    ... safety and quality for automotive adaptive equipment. 17.155 Section 17.155 Pensions, Bonuses, and... Minimum standards of safety and quality for automotive adaptive equipment. (a) The Under Secretary for... officials that it meets implicit standards of safety and quality adopted by the industry or as later...

  20. 77 FR 23117 - Rigging Equipment for Material Handling Construction Standard; Correction and Technical Amendment

    Science.gov (United States)

    2012-04-18

    ... Equipment for Material Handling Construction Standard; Correction and Technical Amendment AGENCY... AND HEALTH REGULATIONS FOR CONSTRUCTION Subpart H--Materials Handling, Storage, Use, and Disposal 0 1... amendment. SUMMARY: OSHA is correcting its sling standard for construction titled ``Rigging Equipment for...

  1. An ROC-type measure of diagnostic accuracy when the gold standard is continuous-scale.

    Science.gov (United States)

    Obuchowski, Nancy A

    2006-02-15

    ROC curves and summary measures of accuracy derived from them, such as the area under the ROC curve, have become the standard for describing and comparing the accuracy of diagnostic tests. Methods for estimating ROC curves rely on the existence of a gold standard which dichotomizes patients into disease present or absent. There are, however, many examples of diagnostic tests whose gold standards are not binary-scale, but rather continuous-scale. Unnatural dichotomization of these gold standards leads to bias and inconsistency in estimates of diagnostic accuracy. In this paper, we propose a non-parametric estimator of diagnostic test accuracy which does not require dichotomization of the gold standard. This estimator has an interpretation analogous to the area under the ROC curve. We propose a confidence interval for test accuracy and a statistical test for comparing accuracies of tests from paired designs. We compare the performance (i.e. CI coverage, type I error rate, power) of the proposed methods with several alternatives. An example is presented where the accuracies of two quick blood tests for measuring serum iron concentrations are estimated and compared.

  2. Carbon finance and pro-poor co-benefits: The Gold Standard and Climate, Community and Biodiversity Standards

    Energy Technology Data Exchange (ETDEWEB)

    Wood, Rachel

    2011-04-15

    This paper assesses the practical contribution of the Gold Standard (GS) and Climate Community and Biodiversity (CCB) Standards to local development through the identification of high quality carbon offset projects and ensuring high standards of consultation with local communities during project development and implementation. It is based on desk research, involving analysis of the GS and CCB Standards' project databases, project design documents, and secondary literature. In addition, over 20 representatives of the two standards systems, project developers, NGO representatives, and researchers were interviewed. The paper concludes that both standard systems successfully reward high quality projects which have a demonstrated commitment to local consultations and sustainable development benefits. Moreover, they serve to give well-meaning project developers frameworks with which to ensure that a wide range of criteria are considered in planning and implementing projects. As voluntary standards, it is unrealistic to expect either the GS or CCB Standards to improve poor-quality or unsustainable projects.

  3. Carbon finance and pro-poor co-benefits: The Gold Standard and Climate, Community and Biodiversity Standards

    Energy Technology Data Exchange (ETDEWEB)

    Wood, Rachel

    2011-04-15

    This paper assesses the practical contribution of the Gold Standard (GS) and Climate Community and Biodiversity (CCB) Standards to local development through the identification of high quality carbon offset projects and ensuring high standards of consultation with local communities during project development and implementation. It is based on desk research, involving analysis of the GS and CCB Standards' project databases, project design documents, and secondary literature. In addition, over 20 representatives of the two standards systems, project developers, NGO representatives, and researchers were interviewed. The paper concludes that both standard systems successfully reward high quality projects which have a demonstrated commitment to local consultations and sustainable development benefits. Moreover, they serve to give well-meaning project developers frameworks with which to ensure that a wide range of criteria are considered in planning and implementing projects. As voluntary standards, it is unrealistic to expect either the GS or CCB Standards to improve poor-quality or unsustainable projects.

  4. Property, Plant and Equipment disclosure requirements and firm characteristics: the Portuguese Accounting Standardization System

    OpenAIRE

    Botelho, Rafaela; Azevedo, Graça; Costa, Alberto J.; Oliveira, Jonas

    2015-01-01

    In the new Portuguese accounting frame of reference (Portuguese Accounting Standardization System – Sistema de Normalização Contabilística), the issues related to Property, Plant and Equipment assets are dealt with in the Accounting and Financial Reporting Standard (Norma Contabilística de Relato Financeiro – NCRF) 7 (Property, Plant & Equipment). The present study intends to assess the degree of compliance with the disclosure requirements of this accounting standard by Portuguese unlisted co...

  5. Building a gold standard to construct search filters: a case study with biomarkers for oral cancer.

    Science.gov (United States)

    Frazier, John J; Stein, Corey D; Tseytlin, Eugene; Bekhuis, Tanja

    2015-01-01

    To support clinical researchers, librarians and informationists may need search filters for particular tasks. Development of filters typically depends on a "gold standard" dataset. This paper describes generalizable methods for creating a gold standard to support future filter development and evaluation using oral squamous cell carcinoma (OSCC) as a case study. OSCC is the most common malignancy affecting the oral cavity. Investigation of biomarkers with potential prognostic utility is an active area of research in OSCC. The methods discussed here should be useful for designing quality search filters in similar domains. The authors searched MEDLINE for prognostic studies of OSCC, developed annotation guidelines for screeners, ran three calibration trials before annotating the remaining body of citations, and measured inter-annotator agreement (IAA). We retrieved 1,818 citations. After calibration, we screened the remaining citations (n = 1,767; 97.2%); IAA was substantial (kappa = 0.76). The dataset has 497 (27.3%) citations representing OSCC studies of potential prognostic biomarkers. The gold standard dataset is likely to be high quality and useful for future development and evaluation of filters for OSCC studies of potential prognostic biomarkers. The methodology we used is generalizable to other domains requiring a reference standard to evaluate the performance of search filters. A gold standard is essential because the labels regarding relevance enable computation of diagnostic metrics, such as sensitivity and specificity. Librarians and informationists with data analysis skills could contribute to developing gold standard datasets and subsequent filters tuned for their patrons' domains of interest.

  6. Human papillomavirus testing as a cytology gold standard : comparing Surinam with the Netherlands

    NARCIS (Netherlands)

    Wachtel, MS; Boon, ME; Korporaal, H; Kok, LP

    Polymerase chain reaction to detect high- risk human papillomavirus has been suggested as a gold standard for cytology. The Netherlands and Surinam were prospectively compared in regard to the proportions of Negative, Atypical Squamous Cells of Undetermined Significance, and Squamous Intraepithelial

  7. Reassessing RCTs as the "Gold Standard": Synergy Not Separatism in Evaluation Designs

    Science.gov (United States)

    Hanley, Pam; Chambers, Bette; Haslam, Jonathan

    2016-01-01

    Randomised controlled trials (RCTs) are increasingly used to evaluate educational interventions in the UK. However, RCTs remain controversial for some elements of the research community. This paper argues that the widespread use of the term "gold standard" to describe RCTs is problematic, as it implies that other research methods are…

  8. Validating Automated Essay Scoring: A (Modest) Refinement of the "Gold Standard"

    Science.gov (United States)

    Powers, Donald E.; Escoffery, David S.; Duchnowski, Matthew P.

    2015-01-01

    By far, the most frequently used method of validating (the interpretation and use of) automated essay scores has been to compare them with scores awarded by human raters. Although this practice is questionable, human-machine agreement is still often regarded as the "gold standard." Our objective was to refine this model and apply it to…

  9. The Gold Standard Program for Smoking Cessation is Effective for Participants Over 60 Years of Age

    DEFF Research Database (Denmark)

    Flamand, Mette Kehlet; Schroeder, Torben V; Tønnesen, Hanne

    2015-01-01

    BACKGROUND: Tobacco smoking is more prevalent among the elderly than among the young, and the elderly also have the most frequent contact with the health care system. The aim of this study was to evaluate the effectiveness of the Gold Standard Program, which is an intensive six-week smoking...

  10. Still no single gold standard for using cementless femoral stems routinely in total hip arthroplasty

    Directory of Open Access Journals (Sweden)

    Joseph T. Moskal, MD

    2016-12-01

    Conclusions: Using evidence-based data should be better guidance in selecting the most reliable implants for THA. Although cementless femoral fixation for THA has evolved to the “new standard,” it has not been proven to be the “gold standard” for all patients.

  11. Evaluation of diagnostic tests when there is no gold standard. A review of methods

    NARCIS (Netherlands)

    Rutjes, A. W. S.; Reitsma, J. B.; Coomarasamy, A.; Khan, K. S.; Bossuyt, P. M. M.

    2007-01-01

    OBJECTIVE: To generate a classification of methods to evaluate medical tests when there is no gold standard. METHODS: Multiple search strategies were employed to obtain an overview of the different methods described in the literature, including searches of electronic databases, contacting experts

  12. Twenty years after Erich Muhe: Persisting controversies with the gold standard of laparoscopic cholecystectomy.

    Science.gov (United States)

    Jani, Kalpesh; Rajan, P S; Sendhilkumar, K; Palanivelu, C

    2006-06-01

    This review article is a tribute to the genius of Professor Erich Muhe, a man ahead of his times. We trace the development of laparoscopic cholecystectomy and detail the tribulations faced by Muhe. On the occasion of the twentieth anniversary of the first laparoscopic cholecystectomy, we take another look at some of the controversies surrounding this gold standard in the management of gallbladder disease.

  13. Twenty years after Erich Muhe: Persisting controversies with the gold standard of laparoscopic cholecystectomy

    OpenAIRE

    Jani, Kalpesh; Rajan, P S; Sendhilkumar, K; Palanivelu, C

    2006-01-01

    This review article is a tribute to the genius of Professor Erich Muhe, a man ahead of his times. We trace the development of laparoscopic cholecystectomy and detail the tribulations faced by Muhe. On the occasion of the twentieth anniversary of the first laparoscopic cholecystectomy, we take another look at some of the controversies surrounding this gold standard in the management of gallbladder disease

  14. Seeking a Valid Gold Standard for an Innovative, Dialect-Neutral Language Test

    Science.gov (United States)

    Pearson, Barbara Zurer; Jackson, Janice E.; Wu, Haotian

    2014-01-01

    Purpose: In this study, the authors explored alternative gold standards to validate an innovative, dialect-neutral language assessment. Method: Participants were 78 African American children, ages 5;0 (years;months) to 6;11. Twenty participants had previously been identified as having language impairment. The Diagnostic Evaluation of Language…

  15. Assessing validity of a depression screening instrument in the absence of a gold standard.

    Science.gov (United States)

    Gelaye, Bizu; Tadesse, Mahlet G; Williams, Michelle A; Fann, Jesse R; Vander Stoep, Ann; Andrew Zhou, Xiao-Hua

    2014-07-01

    We evaluated the extent to which use of a hypothesized imperfect gold standard, the Composite International Diagnostic Interview (CIDI), biases the estimates of diagnostic accuracy of the Patient Health Questionnaire-9 (PHQ-9). We also evaluate how statistical correction can be used to address this bias. The study was conducted among 926 adults where structured interviews were conducted to collect information about participants' current major depressive disorder using PHQ-9 and CIDI instruments. First, we evaluated the relative psychometric properties of PHQ-9 using CIDI as a gold standard. Next, we used a Bayesian latent class model to correct for the bias. In comparison with CIDI, the relative sensitivity and specificity of the PHQ-9 for detecting major depressive disorder at a cut point of 10 or more were 53.1% (95% confidence interval: 45.4%-60.8%) and 77.5% (95% confidence interval, 74.5%-80.5%), respectively. Using a Bayesian latent class model to correct for the bias arising from the use of an imperfect gold standard increased the sensitivity and specificity of PHQ-9 to 79.8% (95% Bayesian credible interval, 64.9%-90.8%) and 79.1% (95% Bayesian credible interval, 74.7%-83.7%), respectively. Our results provided evidence that assessing diagnostic validity of mental health screening instrument, where application of a gold standard might not be available, can be accomplished by using appropriate statistical methods. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. IEEE standard for design qualification of safety systems equipment used in nuclear power generating stations

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    This standard is written to serve as a general standard for qualification of all types of safety systems equipment, mechanical and instrumentation as well as electrical. It also establishes principles and procedures to be followed in preparing specific safety systems equipment standards. Guidance for qualifying specific safety systems equipment may be found in various specific equipment qualification standards that are now available or are being prepared. It is required that safety systems equipment in nuclear power generating stations meet or exceed its performance requirements throughout its installed life. This is accomplished by a disciplined program of design qualification and quality assurance of design, production, installation, maintenance and surveillance. This standard is for the design qualification section of the program only. Design qualification is intended to demonstrate the capability of the equipment design to perform its safety function(s) over the expected range of normal, abnormal, design basis event, post design basis event, and in-service test conditions. Inherent to design qualification is the requirement for demonstration, within limitations afforded by established technical state-of-the-art, that in-service aging throughout the qualified life established for the equipment will not degrade safety systems equipment from its original design condition to the point where it cannot perform its required safety function(s), upon demand. The above requirement reflects the primary role of design qualification to provide reasonable assurance that design- and age-related common failure modes will not occur during performance of safety function(s) under postulated service conditions

  17. PIXE studies on gold standards by protons of energy 3.3 Me V

    International Nuclear Information System (INIS)

    Joseph, Daisy; Saxena, A.; Gupta, S.K.; Kailas, S.

    2005-01-01

    Proton Induced X-ray Emission Technique (PIXE) has been used in analysing Gold standards of 22, 20, 18, and 14 karats with a proton beam of energy 3.3 MeV at the newly commissioned Folded Tandem Ion Accelerator (FOTIA). Well resolved Au and Ag X-rays were detected at a current of 3 nA. Percentage values of gold and silver were calculated and were checked with those obtained by Energy Dispersive X-ray Fluorescence Method and were found to be in agreement with the certified values as well as those obtained by XRF. (author)

  18. NASA safety standard for lifting devices and equipment

    Science.gov (United States)

    1990-09-01

    NASA's minimum safety requirements are established for the design, testing, inspection, maintenance, certification, and use of overhead and gantry cranes (including top running monorail, underhung, and jib cranes), mobile cranes, derrick hoists, and special hoist supported personnel lifting devices (these do not include elevators, ground supported personnel lifts, or powered platforms). Minimum requirements are also addressed for the testing, inspection, and use of Hydra-sets, hooks, and slings. Safety standards are thoroughly detailed.

  19. Challenges of equipment qualification using today's standards with emphasis on a class 1E motor program

    International Nuclear Information System (INIS)

    Deaton, K.

    1995-01-01

    This paper describes qualification of new equipment for safety related service in the nuclear power industry in accordance with current industry standards. This topic is presented from the perspective of an original equipment manufacturer J(OEM). Equipment qualification is first discussed in a general way then an example is provided of an electric motor qualification. A review of alternative qualification methods including commercial dedication is included. Potential difficulties with alternative/expedited qualification methods are also discussed

  20. Gold standard capture cross section from 100 keV to 15 MeV

    International Nuclear Information System (INIS)

    Ryves, T.B.

    1982-01-01

    The capture cross section of gold is now generally accepted as the principal reference standard, and therefore in this review only gold is considered. Recent measurements of the gold capture cross section in the unresolved region are discussed and compared with the ENDF/B-V evaluation. It is concluded that in the energy interval 100 to 2000 keV the present uncertainty in the evaluation is +-8%, in the interval 2 to 3.5 MeV the uncertainty is +-4%, in ther interval 3.5 to 14 MeV more measurements are needed before a realistic error can be assigned, and from 14 to 15 MeV the uncertainty is +-10%. Several recommendations for future work have been made

  1. 78 FR 25627 - Energy Conservation Program for Certain Industrial Equipment: Energy Conservation Standards for...

    Science.gov (United States)

    2013-05-02

    ... average life of the product in the type (or class) compared to any increase in the price of, or in the... well as the market penetration of such equipment. b. Three-Phase Equipment With an Input Capacity Less... standards. This is done by applying a markup multiplier to the manufacturer's [[Page 25632

  2. 14 CFR 25.1445 - Equipment standards for the oxygen distributing system.

    Science.gov (United States)

    2010-01-01

    ... distributing system. 25.1445 Section 25.1445 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... Miscellaneous Equipment § 25.1445 Equipment standards for the oxygen distributing system. (a) When oxygen is supplied to both crew and passengers, the distribution system must be designed for either— (1) A source of...

  3. 76 FR 17573 - Energy Conservation Standards for Commercial Refrigeration Equipment: Public Meeting and...

    Science.gov (United States)

    2011-03-30

    ... INFORMATION: I. Statutory Authority II. History of Standards Rulemaking for Commercial Refrigeration Equipment... feedback from interested parties on its analytical framework, models, and preliminary results. II. History... equipment installed in the field, such as in grocery stores and restaurants. DOE also carries out additional...

  4. 40 CFR 63.305 - Alternative standards for coke oven doors equipped with sheds.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Alternative standards for coke oven doors equipped with sheds. 63.305 Section 63.305 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORIES National Emission Standards for Coke Oven Batteries § 63.305 Alternative standards for...

  5. Endoscopic ultrasound, endoscopic sonoelastography, and strain ratio evaluation of lymph nodes with histology as gold standard

    DEFF Research Database (Denmark)

    Larsen, Michael Hareskov; Fristrup, Claus Wilki; Hansen, Tine Plato

    2012-01-01

    . Endoscopic sonoelastography (ESE) assesses the elasticity of lymph nodes and has been used to differentiate lymph nodes with promising results. The aim of this study was to evaluate the use of EUS, EUS - FNA, ESE, and ESE-strain ratio using histology as the gold standard. PATIENTS AND METHODS: Patients......, EUS - FNA and EUS - FNM were performed. The marked lymph node was isolated during surgery for histological examination. RESULTS: The marked lymph node was isolated for separate histological examination in 56 patients, of whom 22 (39 %) had malignant lymph nodes and 34 (61 %) had benign lymph nodes...... - FNM technique enabled the identification of a specific lymph node and thereby the use of histology as gold standard. ESE and ESE-strain ratio were no better than standard EUS in differentiating between malignant and benign lymph nodes in patients with resectable upper gastrointestinal cancer....

  6. IEEE standard for qualifying class IE equipment for nuclear power generating stations

    International Nuclear Information System (INIS)

    Anon.

    1974-01-01

    The Institute of Electrical and Electrical Engineers, Inc. (IEEE) standards for electrical equipment (Class IE) for nuclear power generating stations are given. The standards are to provide guidance for demonstrating and documenting the adequacy of electric equipment used in all Class IE and interface systems. Representative in containment design basis event conditions for the principal reactor types are included in the appendixes for guidance in enviromental simulation

  7. Electrochemical Recovery of Gold from Waste Electric and Electronic Equipment Using Circulating Particulate Bed Reactor (CPBE)

    Science.gov (United States)

    Ravinder, T.; Ali, U. F. M.; Ridwan, F. M.; Ibrahim, N.; Azmi, N. H.

    2017-06-01

    The utilization of electrochemical process recovery involving low reactant concentrations of metal requires electrodes with high mass transport rates and specific surface areas. This is essential to increase cross-sectional current densities whilst optimizing the capital and operating costs. Experimental results demonstrated that Circulating Particulate Bed Reactor (CPBE) is suitable for the recovery of low concentrations of gold from aqueous chloride solution containing {{AuCl}}4- and {{AuCl}}2- of less than 0.5 mol m-3(< 102 g m-3). Elemental gold was successfully obtained on 0.5-1 mm gr particles in an electrochemical reactor incorporating a cation- permeable membrane and operated in bath recycle mode. Depletion to concentration < 5 × 10-3 mol m-3 (< 1 g m-3) appeared to be mass transport controlled at an applied potential of +0.20 V (SCE), specific electrical energy consumption (SEEC) of ca. 800-1300 kWh h (tonne Au)-1 for cell voltages (U) of 2.0-3.0 V, and fractional current efficiencies of ca. 0.95. However, atomic absorption and UV spectrophotometry established that as the ([{{AuCl}}4-+[{{AuCl}}2-]) concentration decayed, the [{{AuCl}}4-]:[{{AuCl}}2-] molar ratio changed. A multi-step mechanism for reduction of {{AuCl}}4- ions explained this behavior in terms of changing overpotentials for {{AuCl}}4- and {{AuCl}}2- reduction as total dissolved gold concentration decreased. In addition, SEM images confirmed that adherent and coherent Au deposits were achieved with CPBE for Au deposition under mass transport control at 0.20 V (SCE).

  8. Voluntary pulmonary function screening with GOLD standard: an effective and simple approach to detect lung obstruction.

    Science.gov (United States)

    Wang, Shengyu; Gong, Wei; Tian, Yao; Yang, Min

    2015-11-01

    The prevalence of lung obstruction is probably underestimated. Early detection and screening may alter the course and prognosis associated with lung disease. We investigated the effectiveness of voluntary lung function screening program and the agreement between the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and the lower limit of normal (LLN) standard for public screening in Xi'an China. Pulmonary function testing was conducted on volunteers recruited from eight community centers in Xi'an, China between July and August 2012. Participants underwent three forced vital capacity (FVC) maneuvers. The maneuver with the best FEV1 was retained. Participants filled out a medical history survey before undergoing pulmonary function testing. Patients that self-reported lung disease on the health survey were excluded from the analysis. A total of 803 volunteers participated in this study. And 722 participants (93.8%) did not self-report chronic lung disease and were analyzed. Of these participants, 143 subjects (19.8%) were diagnosed by GOLD standard and 134 subjects (18.6%) had obstruction with LLN definition. GOLD definition can identify more asymptomatic subjects (19.1%) with respect to LLN. GOLD definition can detect more lung obstruction in elder subjects compared with young people, the difference is significant (P=0.0007). The overall agreement between the 2 methods was good: the kappa estimate was 0.822. The agreement in subjects aged 40-49, 50-59 and 60-69 years was good: the kappa estimate was 0.82, 0.936 and 0.907 respectively and the agreement in subjects aged 18-29 was inferior: the kappa estimate was only 0.555. Voluntary lung function screening program with GOLD standard may be a simple and effective approach to ensuring high yield detection of lung obstruction in subjects aged 40-69.

  9. A multilingual gold-standard corpus for biomedical concept recognition: the Mantra GSC.

    Science.gov (United States)

    Kors, Jan A; Clematide, Simon; Akhondi, Saber A; van Mulligen, Erik M; Rebholz-Schuhmann, Dietrich

    2015-09-01

    To create a multilingual gold-standard corpus for biomedical concept recognition. We selected text units from different parallel corpora (Medline abstract titles, drug labels, biomedical patent claims) in English, French, German, Spanish, and Dutch. Three annotators per language independently annotated the biomedical concepts, based on a subset of the Unified Medical Language System and covering a wide range of semantic groups. To reduce the annotation workload, automatically generated preannotations were provided. Individual annotations were automatically harmonized and then adjudicated, and cross-language consistency checks were carried out to arrive at the final annotations. The number of final annotations was 5530. Inter-annotator agreement scores indicate good agreement (median F-score 0.79), and are similar to those between individual annotators and the gold standard. The automatically generated harmonized annotation set for each language performed equally well as the best annotator for that language. The use of automatic preannotations, harmonized annotations, and parallel corpora helped to keep the manual annotation efforts manageable. The inter-annotator agreement scores provide a reference standard for gauging the performance of automatic annotation techniques. To our knowledge, this is the first gold-standard corpus for biomedical concept recognition in languages other than English. Other distinguishing features are the wide variety of semantic groups that are being covered, and the diversity of text genres that were annotated. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association.

  10. Twenty years after Erich Muhe: Persisting controversies with the gold standard of laparoscopic cholecystectomy

    Directory of Open Access Journals (Sweden)

    Jani Kalpesh

    2006-01-01

    Full Text Available This review article is a tribute to the genius of Professor Erich Muhe, a man ahead of his times. We trace the development of laparoscopic cholecystectomy and detail the tribulations faced by Muhe. On the occasion of the twentieth anniversary of the first laparoscopic cholecystectomy, we take another look at some of the controversies surrounding this gold standard in the management of gallbladder disease

  11. Low friction arthroplasty and dual mobility cup: a new gold standard.

    Science.gov (United States)

    Prudhon, Jean Louis; Verdier, Régis; Caton, Jacques H

    2017-03-01

    Low friction arthroplasty (LFA) introduced by Sir John Charnley was the gold standard for many years. Dislocation and infection are the first causes for early revision. Late failures are polyethylene (PE) wear and loosening. Due to dislocation risk we slowly switched to the use of LFA with dual mobility cups (DMC). The purposes of this study are (1) to assess whether our changes have improved outcomes and (2) what is the new gold standard? We selected from an observational registry of 1,091 cases of hybrid Charnley total hip arthroplasty (THA). The acetabular component was either DMC in 455 cases or fixed cup (FC) in 636 cases. Three dislocations (0.6%) occurred in the DMC group (none revised). In the FC group 54 dislocated (8.49%) and 20 were recurrent and underwent revision (revision rate 3.14%). In the DMC group, five acetabular and three femoral revisions were performed (revision rate for loosening 1.7%). In the FC group 19 cases underwent acetabular revision, and five cases had femoral component revised (revision rate for loosening 3.7%). Charnley's LFA has proven over 50 years of excellent survivorship. To decrease dislocation risk, one suggested increasing femoral head diameter. Gilles Bousquet proposed another way, namely, the DMC concept. Dislocation is no longer a critical issue with DMC as demonstrated in our series and main series. DMC in primary THA is still a subject of debate. Mid-term results do not demonstrate a higher rate of wear than LFA. What is the current gold standard? LFA was and is our current gold standard in association with a DMC.

  12. A Bayesian method for comparing and combining binary classifiers in the absence of a gold standard

    Directory of Open Access Journals (Sweden)

    Keith Jonathan M

    2012-07-01

    Full Text Available Abstract Background Many problems in bioinformatics involve classification based on features such as sequence, structure or morphology. Given multiple classifiers, two crucial questions arise: how does their performance compare, and how can they best be combined to produce a better classifier? A classifier can be evaluated in terms of sensitivity and specificity using benchmark, or gold standard, data, that is, data for which the true classification is known. However, a gold standard is not always available. Here we demonstrate that a Bayesian model for comparing medical diagnostics without a gold standard can be successfully applied in the bioinformatics domain, to genomic scale data sets. We present a new implementation, which unlike previous implementations is applicable to any number of classifiers. We apply this model, for the first time, to the problem of finding the globally optimal logical combination of classifiers. Results We compared three classifiers of protein subcellular localisation, and evaluated our estimates of sensitivity and specificity against estimates obtained using a gold standard. The method overestimated sensitivity and specificity with only a small discrepancy, and correctly ranked the classifiers. Diagnostic tests for swine flu were then compared on a small data set. Lastly, classifiers for a genome-wide association study of macular degeneration with 541094 SNPs were analysed. In all cases, run times were feasible, and results precise. The optimal logical combination of classifiers was also determined for all three data sets. Code and data are available from http://bioinformatics.monash.edu.au/downloads/. Conclusions The examples demonstrate the methods are suitable for both small and large data sets, applicable to the wide range of bioinformatics classification problems, and robust to dependence between classifiers. In all three test cases, the globally optimal logical combination of the classifiers was found to be

  13. Usage of Latent Class Analysis in Diagnostic Microbiology in the Absence of Gold Standard Test

    Directory of Open Access Journals (Sweden)

    Gul Bayram Abiha

    2016-12-01

    Full Text Available The evaluation of performance of various tests diagnostic tests in the absence of gold standard is an important problem. Latent class analysis (LCA is a statistical analysis method known for many years, especially in the absence of a gold standard for evaluation of diagnostic tests so that LCA has found its wide application area. During the last decade, LCA method has widely used in for determining sensivity and specifity of different microbiological tests. It has investigated in the diagnosis of mycobacterium tuberculosis, mycobacterium bovis, human papilloma virus, bordetella pertussis, influenza viruses, hepatitis E virus (HEV, hepatitis C virus (HCV and other various viral infections. Researchers have compared several diagnostic tests for the diagnosis of different pathogens with LCA. We aimed to evaluate performance of latent class analysis method used microbiological diagnosis in various diseases in several researches. When we took into account all of these tests' results, we suppose that LCA is a good statistical analysis method to assess different test performances in the absence of gold standard. [Archives Medical Review Journal 2016; 25(4.000: 467-488

  14. A study of prostate delineation referenced against a gold standard created from the visible human data

    International Nuclear Information System (INIS)

    Gao Zhanrong; Wilkins, David; Eapen, Libni; Morash, Christopher; Wassef, Youssef; Gerig, Lee

    2007-01-01

    Purpose: To measure inter- and intra-observer variation and systematic error in CT based prostate delineation, where individual delineations are referenced against a gold standard produced from photographic anatomical images from the Visible Human Project (VHP). Materials and methods: The CT and anatomical images of the VHP male form the basic data set for this study. The gold standard was established based on 1 mm thick anatomical photographic images. These were registered against the 3 mm thick CT images that were used for target delineation. A total of 120 organ delineations were performed by six radiation oncologists. Results: The physician delineated prostate volume was on average 30% larger than the 'true' prostate volume, but on average included only 84% of the gold standard volume. Our study found a systematic delineation error such that posterior portions of the prostate were always missed while anteriorly some normal tissue was always defined as target. Conclusions: Our data suggest that radiation oncologists are more concerned with the unintentional inclusion of rectal tissue than they are in missing prostate volume. In contrast, they are likely to overextend the anterior boundary of the prostate to encompass normal tissue such as the bladder

  15. Proteomic Analysis Reveals the Leaf Color Regulation Mechanism in Chimera Hosta "Gold Standard" Leaves.

    Science.gov (United States)

    Yu, Juanjuan; Zhang, Jinzheng; Zhao, Qi; Liu, Yuelu; Chen, Sixue; Guo, Hongliang; Shi, Lei; Dai, Shaojun

    2016-03-08

    Leaf color change of variegated leaves from chimera species is regulated by fine-tuned molecular mechanisms. Hosta "Gold Standard" is a typical chimera Hosta species with golden-green variegated leaves, which is an ideal material to investigate the molecular mechanisms of leaf variegation. In this study, the margin and center regions of young and mature leaves from Hosta "Gold Standard", as well as the leaves from plants after excess nitrogen fertilization were studied using physiological and comparative proteomic approaches. We identified 31 differentially expressed proteins in various regions and development stages of variegated leaves. Some of them may be related to the leaf color regulation in Hosta "Gold Standard". For example, cytosolic glutamine synthetase (GS1), heat shock protein 70 (Hsp70), and chloroplastic elongation factor G (cpEF-G) were involved in pigment-related nitrogen synthesis as well as protein synthesis and processing. By integrating the proteomics data with physiological results, we revealed the metabolic patterns of nitrogen metabolism, photosynthesis, energy supply, as well as chloroplast protein synthesis, import and processing in various leaf regions at different development stages. Additionally, chloroplast-localized proteoforms involved in nitrogen metabolism, photosynthesis and protein processing implied that post-translational modifications were crucial for leaf color regulation. These results provide new clues toward understanding the mechanisms of leaf color regulation in variegated leaves.

  16. 42 CFR 493.1252 - Standard: Test systems, equipment, instruments, reagents, materials, and supplies.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Test systems, equipment, instruments... SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY... storage of reagents and specimens, accurate and reliable test system operation, and test result reporting...

  17. Fungus-mediated synthesis of gold nanoparticles and standardization of parameters for its biosynthesis.

    Science.gov (United States)

    Tidke, Pritish R; Gupta, Indarchand; Gade, Aniket K; Rai, Mahendra

    2014-12-01

    We report the extracellular biosynthesis of gold nanoparticles (AuNPs) using a fungus Fusarium acuminatum. Mycosynthesis of Au-NPs was carried out by challenging the fungal cells filtrate with HAuCl 4 solution (1 mM), as nanoparticles synthesizing enzyme secrete extracellularly by the fungi. The AuNPs were characterized with the help of UV-Visible spectrophotometer, Fourier Transform Infrared spectroscopy, Zeta Potential, X-ray diffraction (XRD) and Transmission electron microscopy (TEM). We observed absorbance peak in between 520 nm-550 nm corresponding to the surface plasmon absorbance of the gold nanoparticles. The nanoparticles synthesized in the present investigation were found to be capped by proteins. XRD results showed that the distinctive formation of crystalline gold nanoparticles in the solution. The spherical and polydispersed AuNPs in the range 8 to 28 nm with average size of 17 nm were observed by TEM analysis. We also standardized the parameters like the effect of pH, temperature and salt concentration on the biosynthesis of gold nanoparticles. It was found that acidic pH, 1 mM salt concentration and 37 (°)C temperature were found to be optimum for the synthesis of Au-NPs. Therefore, the present study introduces the easy, better and cheaper method for biosynthesis of AuNPs.

  18. From plastic to gold: a unified classification scheme for reference standards in medical image processing

    Science.gov (United States)

    Lehmann, Thomas M.

    2002-05-01

    Reliable evaluation of medical image processing is of major importance for routine applications. Nonetheless, evaluation is often omitted or methodically defective when novel approaches or algorithms are introduced. Adopted from medical diagnosis, we define the following criteria to classify reference standards: 1. Reliance, if the generation or capturing of test images for evaluation follows an exactly determined and reproducible protocol. 2. Equivalence, if the image material or relationships considered within an algorithmic reference standard equal real-life data with respect to structure, noise, or other parameters of importance. 3. Independence, if any reference standard relies on a different procedure than that to be evaluated, or on other images or image modalities than that used routinely. This criterion bans the simultaneous use of one image for both, training and test phase. 4. Relevance, if the algorithm to be evaluated is self-reproducible. If random parameters or optimization strategies are applied, reliability of the algorithm must be shown before the reference standard is applied for evaluation. 5. Significance, if the number of reference standard images that are used for evaluation is sufficient large to enable statistically founded analysis. We demand that a true gold standard must satisfy the Criteria 1 to 3. Any standard only satisfying two criteria, i.e., Criterion 1 and Criterion 2 or Criterion 1 and Criterion 3, is referred to as silver standard. Other standards are termed to be from plastic. Before exhaustive evaluation based on gold or silver standards is performed, its relevance must be shown (Criterion 4) and sufficient tests must be carried out to found statistical analysis (Criterion 5). In this paper, examples are given for each class of reference standards.

  19. Harmonization of IEEE323 and IEC60780 standards For Environmental Qualificaiton of Electric Equipment

    International Nuclear Information System (INIS)

    Kim, Jong Seog

    2009-01-01

    IEEE323 standard has been widely used for the qualification of electric equipment in Asian pacific area while IEC6070 has been mostly used in European area. Since each plant use different standard for environmental qualification, manufacturer has to perform the qualification test twice in accordance with each standard. Problem also can be happened in the plant site when they are going to purchase equipment qualified by different qualification standard which are not used in his plant. The need of harmonization of each standard has been raised several years and it is known that some studies are in progress by IEEE committee. KEPRI has a plan of comparing EQ relative standards of IEEE, IEC and RCC in 2009. In this paper, brief comparing result between IEEE323 and IEC60780 and the proper harmonization method is introduced

  20. Gold standards and expert panels: a pulmonary nodule case study with challenges and solutions

    Science.gov (United States)

    Miller, Dave P.; O'Shaughnessy, Kathryn F.; Wood, Susan A.; Castellino, Ronald A.

    2004-05-01

    Comparative evaluations of reader performance using different modalities, e.g. CT with computer-aided detection (CAD) vs. CT without CAD, generally require a "truth" definition based on a gold standard. There are many situations in which a true invariant gold standard is impractical or impossible to obtain. For instance, small pulmonary nodules are generally not assessed by biopsy or resection. In such cases, it is common to use a unanimous consensus or majority agreement from an expert panel as a reference standard for actionability in lieu of the unknown gold standard for disease. Nonetheless, there are three major concerns about expert panel reference standards: (1) actionability is not synonymous with disease (2) it may be possible to obtain different conclusions about which modality is better using different rules (e.g. majority vs. unanimous consensus), and (3) the variability associated with the panelists is not formally captured in the p-values or confidence intervals that are generally produced for estimating the extent to which one modality is superior to the other. A multi-reader-multi-case (MRMC) receiver operating characteristic (ROC) study was performed using 90 cases, 15 readers, and a reference truth based on 3 experienced panelists. The primary analyses were conducted using a reference truth of unanimous consensus regarding actionability (3 out of 3 panelists). To assess the three concerns noted above: (1) additional data from the original radiology reports were compared to the panel (2) the complete analysis was repeated using different definitions of truth, and (3) bootstrap analyses were conducted in which new truth panels were constructed by picking 1, 2, or 3 panelists at random. The definition of the reference truth affected the results for each modality (CT with CAD and CT without CAD) considered by itself, but the effects were similar, so the primary analysis comparing the modalities was robust to the choice of the reference truth.

  1. Contribution of the C.E.A. to standardization of nuclear plant equipments

    International Nuclear Information System (INIS)

    Dumax, P.; Seran, R.

    1980-01-01

    In research and production laboratories working in the nuclear field standardization of equipments greatly improves the profits of the installation and the protection of individuals and goods. The standardization effort on technical equipments of shielding, handling, detection and safety (so called P.M.D.S.) initiated by the C.E.A. in 1967 is being carried out now within the Institute of Protection and Nuclear Safety (I.P.S.N.) by a technical Service specialized in protection and dosimetry (S.T.E.P.D.). Its purpose is to establish standardization documents for internal use and to take part in the work of official standardization organizations. The benefits of standardization are reviewed. The achievements of the various working groups common to C.E.A. centers are stated and the documents published or to be published are listed [fr

  2. Effect of standards on new equipment design by new international standards and industry restraints

    Science.gov (United States)

    Endelman, Lincoln L.

    1991-01-01

    The use of international standards to further trade is one of the objectives of creating a standard. By having form fit and function compatible the free interchange of manufactured goods can be handled without hindrance. Unfortunately by setting up standards that are peculiar to a particular country or district it is possible to exclude competition from a group of manufacturers. A major effort is now underway to develop international laser standards. In the May I 990 issue of Laser Focus World Donald R. Johnson the director of industrial technology services for the National Institute of Standards and Technology (NIST formerly the National Bureau of Standards) is quoted as follows: " The common means of protectionism has been through certification for the market place. " The article goes on to say " Mr. Johnson expects this tradition to continue and that the new European Community (EC) will demand not just safety standards but performance standards as well. . . . the American laser industry must move very quickly on this issue or risk being left behind the European standards bandwagon. " The article continues laser companies must get involved in the actual standards negotiating process if they are to have a say in future policy. A single set of standards would reduce the need to repeatedly recalibrate products for different national markets. " As a member of ISO TC-72 SC9 I am

  3. 40 CFR 63.5734 - What standards must I meet for resin and gel coat application equipment cleaning operations?

    Science.gov (United States)

    2010-07-01

    ... and gel coat application equipment cleaning operations? 63.5734 Section 63.5734 Protection of... Pollutants for Boat Manufacturing Standards for Resin and Gel Coat Application Equipment Cleaning Operations § 63.5734 What standards must I meet for resin and gel coat application equipment cleaning operations...

  4. A strategy for implementation of experience based seismic equipment qualification in IEEE and ASME industry standards

    International Nuclear Information System (INIS)

    Adams, T.M.

    1996-01-01

    In the past 20 years, extensive data on the performance of mechanical and electric equipment during actual strong motion earthquakes and seismic qualification tests has been accumulated. Recognizing that an experience based approach provides a technically sound and cost effective method for the seismic qualification of some or certain equipment, the IEEE Nuclear Power Engineering Committee and the ASME Committee on Qualification of Mechanical Equipment established a Special Working Group to investigate the incorporation of experienced based methods into the industry consensus codes and standards currently used in the seismic qualification of Seismic Category Nuclear Power Plant equipment. This paper presents the strategy (course of action) which was developed by the Special Working Group for meeting this objective of incorporation of experience based seismic qualification standards used in the design and seismic qualification of seismic category nuclear power plant equipment. This strategy was recommended to both chartering organizations, the IEEE Nuclear Power Engineering Committee and the ASME Committee on Qualification of Mechanical Equipment for their consideration and implementation. The status of the review and implementation of the Special Working Group's recommended strategy by the sponsoring organization is also discussed

  5. Evaluation of the Beam Quality of Intraoral X-ray Equipment using Intraoral Standard Films

    International Nuclear Information System (INIS)

    Lee, Sang Sub; Kwon, Hyok Rak; Sim, Woo Hyoun; Oh, Seung Hyoun; Lee, Ji Youn; Jeon, Kug Jin; Kim, Kee Deog; Park, Chang Seo

    2000-01-01

    This study was to evaluate the beam quality of intraoral X-ray equipment used at Yonsei University Dental Hospital (YUDH) using the half value layer (HVL) and the characteristic curve of intraoral standard X-ray film. The study was done using the intraoral X-ray equipment used at each clinical department at YUDH. Aluminum filter was used to determine the HVL. Intraoral standard film was used to get the characteristic curve of each intraoral X-ray equipment. Most of the HVLs of intraoral X-ray equipment were higher than the least recommended thickness, but the REX 601 model used at the operative dentistry department and the X-707 model used at the pediatric dentistry department had HVLs lower than the recommended thickness. The slopes of the characteristic curves of films taken using the PANPAS 601 model and REX 601 model at operative dentistry department, the X-70S model of prosthodontic dentistry department, and the REX 601 model at the student clinic were relatively low. HVL and the characteristic curve of X-ray film can be used to evaluate the beam quality of intraoral X-ray equipment. In order to get the best X-ray films with the least radiation exposure to patients and best diagnostic information in clinical dentistry, X-ray equipment should be managed in the planned and organized fashion.

  6. Establishment of quality assessment standard for mammographic equipment: evaluation of phantom and clinical images

    International Nuclear Information System (INIS)

    Lee, Sung Hoon; Choe, Yeon Hyeon; Chung, Soo Young

    2005-01-01

    The purpose of this study was to establish a quality standard for mammographic equipment Korea and to eventually improve mammographic quality in clinics and hospitals throughout Korea by educating technicians and clinic personnel. For the phantom test and on site assessment, we visited 37 sites and examined 43 sets of mammographic equipment. Items that were examined include phantom test, radiation dose measurement, developer assessment, etc. The phantom images were assessed visually and by optical density measurements. For the clinical image assessment, clinical images from 371 sites were examined following the new Korean standard for clinical image evaluation. The items examined include labeling, positioning, contrast, exposure, artifacts, collimation among others. Quality standard of mammographic equipment was satisfied in all equipment on site visits. Average mean glandular dose was 114.9 mRad. All phantom image test scores were over 10 points (average, 10.8 points). However, optical density measurements were below 1.2 in 9 sets of equipment (20.9%). Clinical image evaluation revealed appropriate image quality in 83.5%, while images from non-radiologist clinics were adequate in 74.6% (91/122), which was the lowest score of any group. Images were satisfactory in 59.0% (219/371) based on evaluation by specialists following the new Korean standard for clinical image evaluation. Satisfactory images had a mean score of 81.7 (1 S.D. =8.9) and unsatisfactory images had a mean score of 61.9 (1 S.D = 11). The correlation coefficient between the two observers was 0.93 (ρ < 0.01) in 49 consecutive cases. The results of the phantom tests suggest that optical density measurements should be performed as part of a new quality standard for mammographic equipment. The new clinical evaluation criteria that was used in this study can be implemented with some modifications for future mammography quality control by the Korean government

  7. [Investigation report on the technical standards of TCM diagnosis, treatment and rehabilitation equipment].

    Science.gov (United States)

    Shen, Hua; Liu, Tangyi; Yang, Huayuan

    2016-02-01

    The questionnaire was adopted so as to investigate the attitudes and recognition of the manufacture eneprises of TCM diagnosis, treatment and rehabilitation equipment (DTRE) to the technical standards of, relevant products. It was found that the construction of the industrial standard and the national standard was lagged behind on TCM DTRE. Under the new situation, the enterprises are highly willing to participate in the development of the industrial, national and international standards and have a certain of understanding on the standard development. Nearly 80 % of enterprises believed that it was necessary to set up the relevant mirror organization for the development of industrial, national and international standard of TCM DITRE. In the future, the standard construction of TCM DTRE must face to the new situation. The constant increasing of the enterprises. and scientific research organizations in the standard construction must promote the development of TCM DTRE.

  8. Status of pre-processing of waste electrical and electronic equipment in Germany and its influence on the recovery of gold.

    Science.gov (United States)

    Chancerel, Perrine; Bolland, Til; Rotter, Vera Susanne

    2011-03-01

    Waste electrical and electronic equipment (WEEE) contains gold in low but from an environmental and economic point of view relevant concentration. After collection, WEEE is pre-processed in order to generate appropriate material fractions that are sent to the subsequent end-processing stages (recovery, reuse or disposal). The goal of this research is to quantify the overall recovery rates of pre-processing technologies used in Germany for the reference year 2007. To achieve this goal, facilities operating in Germany were listed and classified according to the technology they apply. Information on their processing capacity was gathered by evaluating statistical databases. Based on a literature review of experimental results for gold recovery rates of different pre-processing technologies, the German overall recovery rate of gold at the pre-processing level was quantified depending on the characteristics of the treated WEEE. The results reveal that - depending on the equipment groups - pre-processing recovery rates of gold of 29 to 61% are achieved in Germany. Some practical recommendations to reduce the losses during pre-processing could be formulated. Defining mass-based recovery targets in the legislation does not set incentives to recover trace elements. Instead, the priorities for recycling could be defined based on other parameters like the environmental impacts of the materials. The implementation of measures to reduce the gold losses would also improve the recovery of several other non-ferrous metals like tin, nickel, and palladium.

  9. Assessing operating characteristics of CAD algorithms in the absence of a gold standard

    International Nuclear Information System (INIS)

    Roy Choudhury, Kingshuk; Paik, David S.; Yi, Chin A.; Napel, Sandy; Roos, Justus; Rubin, Geoffrey D.

    2010-01-01

    Purpose: The authors examine potential bias when using a reference reader panel as ''gold standard'' for estimating operating characteristics of CAD algorithms for detecting lesions. As an alternative, the authors propose latent class analysis (LCA), which does not require an external gold standard to evaluate diagnostic accuracy. Methods: A binomial model for multiple reader detections using different diagnostic protocols was constructed, assuming conditional independence of readings given true lesion status. Operating characteristics of all protocols were estimated by maximum likelihood LCA. Reader panel and LCA based estimates were compared using data simulated from the binomial model for a range of operating characteristics. LCA was applied to 36 thin section thoracic computed tomography data sets from the Lung Image Database Consortium (LIDC): Free search markings of four radiologists were compared to markings from four different CAD assisted radiologists. For real data, bootstrap-based resampling methods, which accommodate dependence in reader detections, are proposed to test of hypotheses of differences between detection protocols. Results: In simulation studies, reader panel based sensitivity estimates had an average relative bias (ARB) of -23% to -27%, significantly higher (p-value <0.0001) than LCA (ARB -2% to -6%). Specificity was well estimated by both reader panel (ARB -0.6% to -0.5%) and LCA (ARB 1.4%-0.5%). Among 1145 lesion candidates LIDC considered, LCA estimated sensitivity of reference readers (55%) was significantly lower (p-value 0.006) than CAD assisted readers' (68%). Average false positives per patient for reference readers (0.95) was not significantly lower (p-value 0.28) than CAD assisted readers' (1.27). Conclusions: Whereas a gold standard based on a consensus of readers may substantially bias sensitivity estimates, LCA may be a significantly more accurate and consistent means for evaluating diagnostic accuracy.

  10. A studentized permutation test for three-arm trials in the 'gold standard' design.

    Science.gov (United States)

    Mütze, Tobias; Konietschke, Frank; Munk, Axel; Friede, Tim

    2017-03-15

    The 'gold standard' design for three-arm trials refers to trials with an active control and a placebo control in addition to the experimental treatment group. This trial design is recommended when being ethically justifiable and it allows the simultaneous comparison of experimental treatment, active control, and placebo. Parametric testing methods have been studied plentifully over the past years. However, these methods often tend to be liberal or conservative when distributional assumptions are not met particularly with small sample sizes. In this article, we introduce a studentized permutation test for testing non-inferiority and superiority of the experimental treatment compared with the active control in three-arm trials in the 'gold standard' design. The performance of the studentized permutation test for finite sample sizes is assessed in a Monte Carlo simulation study under various parameter constellations. Emphasis is put on whether the studentized permutation test meets the target significance level. For comparison purposes, commonly used Wald-type tests, which do not make any distributional assumptions, are included in the simulation study. The simulation study shows that the presented studentized permutation test for assessing non-inferiority in three-arm trials in the 'gold standard' design outperforms its competitors, for instance the test based on a quasi-Poisson model, for count data. The methods discussed in this paper are implemented in the R package ThreeArmedTrials which is available on the comprehensive R archive network (CRAN). Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  11. No-gold-standard evaluation of image-acquisition methods using patient data.

    Science.gov (United States)

    Jha, Abhinav K; Frey, Eric

    2017-02-11

    Several new and improved modalities, scanners, and protocols, together referred to as image-acquisition methods (IAMs), are being developed to provide reliable quantitative imaging. Objective evaluation of these IAMs on the clinically relevant quantitative tasks is highly desirable. Such evaluation is most reliable and clinically decisive when performed with patient data, but that requires the availability of a gold standard, which is often rare. While no-gold-standard (NGS) techniques have been developed to clinically evaluate quantitative imaging methods, these techniques require that each of the patients be scanned using all the IAMs, which is expensive, time consuming, and could lead to increased radiation dose. A more clinically practical scenario is where different set of patients are scanned using different IAMs. We have developed an NGS technique that uses patient data where different patient sets are imaged using different IAMs to compare the different IAMs. The technique posits a linear relationship, characterized by a slope, bias, and noise standard-deviation term, between the true and measured quantitative values. Under the assumption that the true quantitative values have been sampled from a unimodal distribution, a maximum-likelihood procedure was developed that estimates these linear relationship parameters for the different IAMs. Figures of merit can be estimated using these linear relationship parameters to evaluate the IAMs on the basis of accuracy, precision, and overall reliability. The proposed technique has several potential applications such as in protocol optimization, quantifying difference in system performance, and system harmonization using patient data.

  12. Progression-free survival: gaining on overall survival as a gold standard and accelerating drug development.

    Science.gov (United States)

    Lebwohl, David; Kay, Andrea; Berg, William; Baladi, Jean Francois; Zheng, Ji

    2009-01-01

    In clinical trials of oncology drugs, overall survival (OS) is a direct measure of clinical efficacy and is considered the gold standard primary efficacy end point. The purpose of this study was to discuss the difficulties in using OS as a primary efficacy end point in the setting of evolving cancer therapies. We suggest that progression-free survival is an appropriate efficacy end point in many types of cancer, specifically those for which OS is expected to be prolonged and for which subsequent treatments are expected to affect OS.

  13. 78 FR 54197 - Energy Efficiency Program for Commercial and Industrial Equipment: Energy Conservation Standards...

    Science.gov (United States)

    2013-09-03

    .... EERE-2013-BT-STD-0030] RIN 1904-AD01 Energy Efficiency Program for Commercial and Industrial Equipment: Energy Conservation Standards for Commercial Packaged Boilers AGENCY: Office of Energy Efficiency and..., Office of Energy Efficiency and Renewable Energy, Building Technologies Office, EE-2J, 1000 Independence...

  14. 49 CFR 571.108, Nt. - Standard No. 108; Lamps, reflective devices, and associated equipment.

    Science.gov (United States)

    2010-10-01

    ... subparagraph (f) of this paragraph, and after cooling to room ambient temperature, a test specimen shall show....4Except for multifunction school activity buses, each school bus shall be equipped with a system of either: (a) Four red signal lamps designed to conform to SAE Standard J887, School Bus Red Signal Lamps, July...

  15. Qualification of Programmable Electronic System (PES) equipment based on international nuclear I and C standards

    International Nuclear Information System (INIS)

    De Grosbois, J.; Hepburn, G. A.; Olmstead, R.; Goble, W.; Kumar, V.

    2006-01-01

    Nuclear power plants (NPPs) are increasingly faced with the challenge of qualifying procured equipment, sub-components, and systems that contain digital programmed electronics for use in safety-related applications. Referred to as a 'programmable electronic system' (PES), such equipment typically contains both complex logic that is vulnerable to systematic design faults, and low voltage electronics hardware that is subject to random faults. Procured PES products or components are often only commercial grade, yet can offer reliable cost effective alternatives to custom-designed or nuclear qualified equipment, provided they can be shown to meet the quality assurance, functional safety, environmental, and reliability requirements of a particular application. The process of confirming this is referred to as application-specific product qualification (ASPQ) and can be challenging and costly. This paper provides an overview of an approach that has been developed at Atomic Energy Canada Limited (AECL) and successfully applied to PES equipment intended for use in domestic Candu R 6 nuclear power plants and special purpose reactors at Chalk River Laboratories. The approach has evolved over the past decade and has recently been adapted to be consistent with, and take advantage of new standards that are applicable to nuclear safety-related I and C systems. Also discussed are how recognized third-party safety-certifications of PES equipment to International Electrotechnical Commission (IEC) standards, and the assessment methods employed, may be used to reduce ASPQ effort. (authors)

  16. Development of a standard operating procedure for mammography equipment used in calibration of ionized chambers

    International Nuclear Information System (INIS)

    Rodrigues, Yklys Santos; Potiens, Maria da Penha Albuquerque

    2011-01-01

    Mammography is one widely used technique in the detection of breast cancer. In order to optimize the results achieving better images with lower dose rates, a quality assurance programme must be applied to the equipment. Some control tests use ionization chambers to measure air kerma and other quantities. These tests can only be reliable if the ionization chambers used on them are correctly calibrated. In the present work, it was developed a standard operating procedure (SOP) for quality control tests in a commercial mammography equipment installed in the Calibration Laboratory (LCI) at IPEN - Brazilian Institute for energy and nuclear research). Seven tests were performed in the equipment: Tube voltage and exposition time accuracy and reproducibility, linearity and reproducibility of Air kerma and Half Value Layer (HVL). Then, it was made a measurement of the air kerma in the mammography equipment, using a reference ionization chamber with traceability to a primary laboratory in Germany (Physikalisch-Technische Bundesanstalt - PTB), that was later compared with the air kerma measured in an industrial irradiator. This industrial X-ray generator was recently used in the implementation of X-radiation Standards beams, mammography level, following the Standard IEC 61267. The HVL values varied from 0.36 (25kV) to 0.41 mmA1 (35kV), and the measured air kerma rates were between 9.78 and 17.97 mGy/min. (author)

  17. Evaluation of the accuracy of diagnostic scales for a syndrome in Chinese medicine in the absence of a gold standard.

    Science.gov (United States)

    Wang, Xiao Nan; Zhou, Vanessa; Liu, Qiang; Gao, Ying; Zhou, Xiao-Hua

    2016-01-01

    The concept of syndromes (zhengs) is unique to Chinese medicine (CM) and difficult to measure. Expert consensus is used as a gold standard to identify zhengs and evaluate the accuracy of existing diagnostic scales for zhengs. But, the use of expert consensus as a gold standard is problematic because the diagnosis of zhengs by expert consensus is not 100 % accurate. This study aimed to evaluate the accuracy of standardized diagnostic scales for a syndrome zhengs in the absence of a gold standard, with application to internal wind (nei feng) syndrome in ischemic stroke patients. A total of 204 participants (age 41-84 years) with ischemic stroke were assessed by the stroke syndrome differentiation diagnostic criterion (SSDC), ischemic stroke TCM syndrome diagnostic scale (ISDS), and expert syndrome differentiation (ESD). The diagnostic tests and data collection process were conducted over a 10-month period (February 2008 to November 2008) in 10 hospitals across nine cities in China. The Bayesian method was used to estimate the accuracy of the SSDC, ISDS, and ESD. For internal wind syndrome, the estimated sensitivities and specificities of the SSDC, ISDS, and ESD without use of a gold standard were respectively: [Formula: see text], [Formula: see text]; [Formula: see text], [Formula: see text]; and [Formula: see text], [Formula: see text]. After adjusting for imperfect gold standard bias, we found that both the sensitivity and specificity of the ISDS were higher than those of the SSDC for diagnosis of internal wind syndrome in ischemic stroke patients.

  18. Review and evaluation of technology, equipment, codes and standards for digitization of industrial radiographic film

    International Nuclear Information System (INIS)

    1992-05-01

    This reports contains a review and evaluation of the technology, equipment, and codes and standards related to the digitization of industrial radiographic film. The report presents recommendations and equipment-performance specifications that will allow the digitization of radiographic film from nuclear power plant components in order to produce faithful reproductions of flaw images of interest on the films. Justification for the specifications selected are provided. Performance demonstration tests for the digitization process are required and criteria for such tests is presented. Also several comments related to implementation of the technology are presented and discussed

  19. Diagnostic accuracy of tuberculous lymphadenitis fine needle aspiration biopsy confirmed by PCR as gold standard

    Science.gov (United States)

    DSuryadi; Delyuzar; Soekimin

    2018-03-01

    Indonesia is the second country with the TB (tuberculosis) burden in the world. Improvement in controlling TB and reducing the complications can accelerate early diagnosis and correct treatment. PCR test is a gold standard. However, it is quite expensive for routine diagnosis. Therefore, an accurate and cheaper diagnostic method such as fine needle aspiration biopsy is needed. The study aimsto determine the accuracy of fine needle aspiration biopsy cytology in the diagnosis of tuberculous lymphadenitis. A cross-sectional analytic study was conducted to the samples from patients suspected with tuberculous lymphadenitis. The fine needle aspiration biopsy (FNAB)test was performed and confirmed by PCR test.There is a comparison to the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of both methods. Sensitivity (92.50%), specificity (96.49%), accuracy (94.85%), positive predictive value (94.87%) and negative predictive value (94.83%) were in FNAB test compared to gold standard. We concluded that fine needle aspiration biopsy is a recommendation for a cheaper and accurate diagnostic test for tuberculous lymphadenitis diagnosis.

  20. Scattering resonances in bimolecular collisions between NO radicals and H2 challenge the theoretical gold standard

    Science.gov (United States)

    Vogels, Sjoerd N.; Karman, Tijs; Kłos, Jacek; Besemer, Matthieu; Onvlee, Jolijn; van der Avoird, Ad; Groenenboom, Gerrit C.; van de Meerakker, Sebastiaan Y. T.

    2018-02-01

    Over the last 25 years, the formalism known as coupled-cluster (CC) theory has emerged as the method of choice for the ab initio calculation of intermolecular interaction potentials. The implementation known as CCSD(T) is often referred to as the gold standard in quantum chemistry. It gives excellent agreement with experimental observations for a variety of energy-transfer processes in molecular collisions, and it is used to calibrate density functional theory. Here, we present measurements of low-energy collisions between NO radicals and H2 molecules with a resolution that challenges the most sophisticated quantum chemistry calculations at the CCSD(T) level. Using hitherto-unexplored anti-seeding techniques to reduce the collision energy in a crossed-beam inelastic-scattering experiment, a resonance structure near 14 cm-1 is clearly resolved in the state-to-state integral cross-section, and a unique resonance fingerprint is observed in the corresponding differential cross-section. This resonance structure discriminates between two NO-H2 potentials calculated at the CCSD(T) level and pushes the required accuracy beyond the gold standard.

  1. Gold Standards,” Plurality and Monocultures: The Need for Diversity in Psychotherapy

    Science.gov (United States)

    Leichsenring, Falk; Abbass, Allan; Hilsenroth, Mark J.; Luyten, Patrick; Munder, Thomas; Rabung, Sven; Steinert, Christiane

    2018-01-01

    For psychotherapy of mental disorders, presently several approaches are available, such as interpersonal, humanistic, systemic, psychodynamic or cognitive behavior therapy (CBT). Pointing to the available evidence, proponents of CBT claim that CBT is the gold standard. Some authors even argue for an integrated CBT-based form of psychotherapy as the only form of psychotherapy. CBT undoubtedly has its strengths and CBT researchers have to be credited for developing and testing treatments for many mental disorders. A critical review, however, shows that the available evidence for the theoretical foundations of CBT, assumed mechanisms of change, quality of studies, and efficacy is not as robust as some researchers claim. Most important, there is no consistent evidence that CBT is more efficacious than other evidence-based approaches. These findings do not justify regarding CBT as the gold standard psychotherapy. They even provide less justification for the idea that the future of psychotherapy lies in one integrated CBT-based form of psychotherapy as the only type of psychotherapy. For the different psychotherapeutic approaches a growing body of evidence is available. These approaches have their strengths because of differences in their respective focus on interpersonal relationships, affects, cognitions, systemic perspectives, experiential, or unconscious processes. Different approaches may be suitable to different patients and therapists. As generally assumed, progress in research results from openness to new ideas and learning from diverse perspectives. Thus, different forms of evidence-based psychotherapy are required. Plurality is the future of psychotherapy, not a uniform “one fits all” approach. PMID:29740361

  2. IEEE Std 323-1983: IEEE standard for qualifying Class 1E equipment for nuclear power generating stations

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This standard describes the basic requirements for qualifying Class 1E equipment with interfaces that are to be used in nuclear power generating stations. The requirements presented include the principles, procedures, and methods of qualification. These qualification requirements, when met, will confirm the adequacy of the equipment design under normal, abnormal, design basis event, post design basis event, and in-service test conditions for the performance of safety function(s). The purpose of this standard is to identify requirements for the qualification of Class 1E equipment, including those interfaces whose failure could adversely affect the performance of Class 1E equipment and systems. The methods described shall be used for qualifying equipment, extending qualification, and updating qualification if the equipment is modified. Other issued IEEE standards which present qualification methods for specific equipment or components, or both, and those that deal with parts of the qualification program, may be used to supplement this standard, as applicable

  3. PET/CT in cancer: moderate sample sizes may suffice to justify replacement of a regional gold standard

    DEFF Research Database (Denmark)

    Gerke, Oke; Poulsen, Mads Hvid; Bouchelouche, Kirsten

    2009-01-01

    PURPOSE: For certain cancer indications, the current patient evaluation strategy is a perfect but locally restricted gold standard procedure. If positron emission tomography/computed tomography (PET/CT) can be shown to be reliable within the gold standard region and if it can be argued that PET...... of metastasized prostate cancer. RESULTS: An added value in accuracy of PET/CT in adjacent areas can outweigh a downsized target level of accuracy in the gold standard region, justifying smaller sample sizes. CONCLUSIONS: If PET/CT provides an accuracy benefit in adjacent regions, then sample sizes can be reduced....../CT also performs well in adjacent areas, then sample sizes in accuracy studies can be reduced. PROCEDURES: Traditional standard power calculations for demonstrating sensitivities of both 80% and 90% are shown. The argument is then described in general terms and demonstrated by an ongoing study...

  4. Exploring How Peer Communities Enable Lead User Innovations to Become Standard Equipment in the Industry

    DEFF Research Database (Denmark)

    Hienerth, Christoph; Lettl, Christopher

    2011-01-01

    Literature on new product development indicates that on average around 40% of new products fail across different industries (e.g., Crawford, ; Crawford and Di Benedetto, ). Out of those that survive only few become widely accepted standard equipment in the industry (Utterback, ). Literature...... they are developed. It is therefore the aim of this study to shed light on how innovations become widely accepted by large segments of the market and specifically which demand-side forces are at work. An approach suitable for pursuing this objective is to focus on those individuals who are on the leading edge...... with respect to an important market trend (lead users) and their respective peer communities. As little knowledge is available, an explorative case study design is applied, working with cases from two different industries, specifically the medical equipment and sporting equipment industry. A longitudinal...

  5. Task-based evaluation of segmentation algorithms for diffusion-weighted MRI without using a gold standard

    International Nuclear Information System (INIS)

    Jha, Abhinav K; Kupinski, Matthew A; Rodríguez, Jeffrey J; Stephen, Renu M; Stopeck, Alison T

    2012-01-01

    In many studies, the estimation of the apparent diffusion coefficient (ADC) of lesions in visceral organs in diffusion-weighted (DW) magnetic resonance images requires an accurate lesion-segmentation algorithm. To evaluate these lesion-segmentation algorithms, region-overlap measures are used currently. However, the end task from the DW images is accurate ADC estimation, and the region-overlap measures do not evaluate the segmentation algorithms on this task. Moreover, these measures rely on the existence of gold-standard segmentation of the lesion, which is typically unavailable. In this paper, we study the problem of task-based evaluation of segmentation algorithms in DW imaging in the absence of a gold standard. We first show that using manual segmentations instead of gold-standard segmentations for this task-based evaluation is unreliable. We then propose a method to compare the segmentation algorithms that does not require gold-standard or manual segmentation results. The no-gold-standard method estimates the bias and the variance of the error between the true ADC values and the ADC values estimated using the automated segmentation algorithm. The method can be used to rank the segmentation algorithms on the basis of both the ensemble mean square error and precision. We also propose consistency checks for this evaluation technique. (paper)

  6. Development of a standard equipment management model for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Hee Seung; Ju, Tae Young; Kim, Jung Wun [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2012-10-15

    Most utilities that have achieved high performance have introduced a management model to improve performance and operate plants safely. The Nuclear Energy Institute has developed and updated its Standard Nuclear Performance Model (SNPM) in order to provide a summary of nuclear processes, cost definitions, and key business performance measures for business performance comparison and benchmarking. Over the past decade, Korea Hydro and Nuclear Power Co. (KHNP) has introduced and implemented many engineering processes such as Equipment Reliability (ER), Maintenance Rule (MR), Single Point Vulnerability (SPV), Corrective Action Program (CAP), and Self Assessment (SA) to improve plant performance and to sustain high performance. Some processes, however, are not well interfaced with other processes, because they were developed separately and were focused on the process itself. KHNP is developing a Standard Equipment Management Model (SEMM) to integrate these engineering processes and to improve the interrelation among the processes. In this paper, a draft model and attributes of the SEMM are discussed.

  7. Development of a standard equipment management model for nuclear power plants

    International Nuclear Information System (INIS)

    Chang, Hee Seung; Ju, Tae Young; Kim, Jung Wun

    2012-01-01

    Most utilities that have achieved high performance have introduced a management model to improve performance and operate plants safely. The Nuclear Energy Institute has developed and updated its Standard Nuclear Performance Model (SNPM) in order to provide a summary of nuclear processes, cost definitions, and key business performance measures for business performance comparison and benchmarking. Over the past decade, Korea Hydro and Nuclear Power Co. (KHNP) has introduced and implemented many engineering processes such as Equipment Reliability (ER), Maintenance Rule (MR), Single Point Vulnerability (SPV), Corrective Action Program (CAP), and Self Assessment (SA) to improve plant performance and to sustain high performance. Some processes, however, are not well interfaced with other processes, because they were developed separately and were focused on the process itself. KHNP is developing a Standard Equipment Management Model (SEMM) to integrate these engineering processes and to improve the interrelation among the processes. In this paper, a draft model and attributes of the SEMM are discussed

  8. A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods.

    Science.gov (United States)

    Jha, Abhinav K; Caffo, Brian; Frey, Eric C

    2016-04-07

    The objective optimization and evaluation of nuclear-medicine quantitative imaging methods using patient data is highly desirable but often hindered by the lack of a gold standard. Previously, a regression-without-truth (RWT) approach has been proposed for evaluating quantitative imaging methods in the absence of a gold standard, but this approach implicitly assumes that bounds on the distribution of true values are known. Several quantitative imaging methods in nuclear-medicine imaging measure parameters where these bounds are not known, such as the activity concentration in an organ or the volume of a tumor. We extended upon the RWT approach to develop a no-gold-standard (NGS) technique for objectively evaluating such quantitative nuclear-medicine imaging methods with patient data in the absence of any ground truth. Using the parameters estimated with the NGS technique, a figure of merit, the noise-to-slope ratio (NSR), can be computed, which can rank the methods on the basis of precision. An issue with NGS evaluation techniques is the requirement of a large number of patient studies. To reduce this requirement, the proposed method explored the use of multiple quantitative measurements from the same patient, such as the activity concentration values from different organs in the same patient. The proposed technique was evaluated using rigorous numerical experiments and using data from realistic simulation studies. The numerical experiments demonstrated that the NSR was estimated accurately using the proposed NGS technique when the bounds on the distribution of true values were not precisely known, thus serving as a very reliable metric for ranking the methods on the basis of precision. In the realistic simulation study, the NGS technique was used to rank reconstruction methods for quantitative single-photon emission computed tomography (SPECT) based on their performance on the task of estimating the mean activity concentration within a known volume of interest

  9. A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods

    International Nuclear Information System (INIS)

    Jha, Abhinav K; Frey, Eric C; Caffo, Brian

    2016-01-01

    The objective optimization and evaluation of nuclear-medicine quantitative imaging methods using patient data is highly desirable but often hindered by the lack of a gold standard. Previously, a regression-without-truth (RWT) approach has been proposed for evaluating quantitative imaging methods in the absence of a gold standard, but this approach implicitly assumes that bounds on the distribution of true values are known. Several quantitative imaging methods in nuclear-medicine imaging measure parameters where these bounds are not known, such as the activity concentration in an organ or the volume of a tumor. We extended upon the RWT approach to develop a no-gold-standard (NGS) technique for objectively evaluating such quantitative nuclear-medicine imaging methods with patient data in the absence of any ground truth. Using the parameters estimated with the NGS technique, a figure of merit, the noise-to-slope ratio (NSR), can be computed, which can rank the methods on the basis of precision. An issue with NGS evaluation techniques is the requirement of a large number of patient studies. To reduce this requirement, the proposed method explored the use of multiple quantitative measurements from the same patient, such as the activity concentration values from different organs in the same patient. The proposed technique was evaluated using rigorous numerical experiments and using data from realistic simulation studies. The numerical experiments demonstrated that the NSR was estimated accurately using the proposed NGS technique when the bounds on the distribution of true values were not precisely known, thus serving as a very reliable metric for ranking the methods on the basis of precision. In the realistic simulation study, the NGS technique was used to rank reconstruction methods for quantitative single-photon emission computed tomography (SPECT) based on their performance on the task of estimating the mean activity concentration within a known volume of interest

  10. A Gold Standards Approach to Training Instructors to Evaluate Crew Performance

    Science.gov (United States)

    Baker, David P.; Dismukes, R. Key

    2003-01-01

    The Advanced Qualification Program requires that airlines evaluate crew performance in Line Oriented Simulation. For this evaluation to be meaningful, instructors must observe relevant crew behaviors and evaluate those behaviors consistently and accurately against standards established by the airline. The airline industry has largely settled on an approach in which instructors evaluate crew performance on a series of event sets, using standardized grade sheets on which behaviors specific to event set are listed. Typically, new instructors are given a class in which they learn to use the grade sheets and practice evaluating crew performance observed on videotapes. These classes emphasize reliability, providing detailed instruction and practice in scoring so that all instructors within a given class will give similar scores to similar performance. This approach has value but also has important limitations; (1) ratings within one class of new instructors may differ from those of other classes; (2) ratings may not be driven primarily by the specific behaviors on which the company wanted the crews to be scored; and (3) ratings may not be calibrated to company standards for level of performance skill required. In this paper we provide a method to extend the existing method of training instructors to address these three limitations. We call this method the "gold standards" approach because it uses ratings from the company's most experienced instructors as the basis for training rater accuracy. This approach ties the training to the specific behaviors on which the experienced instructors based their ratings.

  11. A survey of current and anticipated use of standard and specialist equipment by UK optometrists.

    Science.gov (United States)

    Dabasia, Priya L; Edgar, David F; Garway-Heath, David F; Lawrenson, John G

    2014-09-01

    To investigate current and anticipated use of equipment and information technology (IT) in community optometric practice in the UK, and to elicit optometrists' views on adoption of specialist equipment and IT. An anonymous online questionnaire was developed, covering use of standard and specialist diagnostic equipment, and IT. The survey was distributed to a random sample of 1300 UK College of Optometrists members. Four hundred and thirty-two responses were received (response rate = 35%). Enhanced (locally commissioned) or additional/separately contracted services were provided by 73% of respondents. Services included glaucoma repeat measures (30% of respondents), glaucoma referral refinement (22%), fast-track referral for wet age-related macular degeneration (48%), and direct cataract referral (40%). Most respondents (88%) reported using non-contact/pneumo tonometry for intra-ocular pressure measurement, with 81% using Goldmann or Perkins tonometry. The most widely used item of specialist equipment was the fundus camera (74% of respondents). Optical Coherence Tomography (OCT) was used by 15% of respondents, up from 2% in 2007. Notably, 43% of those anticipating purchasing specialist equipment in the next 12 months planned to buy an OCT. 'Paperless' records were used by 39% of respondents, and almost 80% of practices used an electronic patient record/practice management system. Variations in responses between parts of the UK reflect differences in the provision of the General Ophthalmic Services contract or community enhanced services. There was general agreement that specialised equipment enhances clinical care, permits increased involvement in enhanced services, promotes the practice and can be used as a defence in clinico-legal cases, but initial costs and ongoing maintenance can be a financial burden. Respondents generally agreed that IT facilitates administrative flow and secure exchange of health information, and promotes a state-of-the-art practice image

  12. Role of hydrogen ions in standard and activation heap leaching of gold

    Science.gov (United States)

    Rubtsov, YuI

    2017-02-01

    The role of hydrogen ions in activation heap leaching of gold from rebellious ore has been studied, which has allowed enhancing gold recovery. The author puts forward a gold leaching circuit with the use of activated oxygen-saturated solutions acidified to pH = 6-9.

  13. Gold standard program for heavy smokers in a real-life setting

    DEFF Research Database (Denmark)

    Neumann, Tim; Rasmussen, Mette; Heitmann, Berit L

    2013-01-01

    Background: High-intensity smoking cessation programs generally lead to more continuous abstinence, however, lower rates of success have been reported among heavy smokers. The aim was to evaluate continuous abstinence among heavy smokers during the intensive 6-week Gold Standard Program (GSP......) and to identify modifiable factors associated with continuous abstinence. Methods: In this nationwide clinical study based on 36,550 smokers attending an intensive cessation program in Denmark. Heavy smoking was defined as ≥7 points in the Fagerström Nicotine Dependency Test, smoking ≥20 cigarettes daily or ≥20...... pack-years. Results: Overall, 28% had a Fagerström score ≥7 points, 58% smoked ≥20 cigarettes daily and 68% smoked ≥20 pack-years. Continuous abstinence was 33% in responders (6-months response rate: 78%); however, abstinence was approximately 1-6% lower in the heavy smokers than the overall population...

  14. Gold-standard evaluation of a folksonomy-based ontology learning model

    Science.gov (United States)

    Djuana, E.

    2018-03-01

    Folksonomy, as one result of collaborative tagging process, has been acknowledged for its potential in improving categorization and searching of web resources. However, folksonomy contains ambiguities such as synonymy and polysemy as well as different abstractions or generality problem. To maximize its potential, some methods for associating tags of folksonomy with semantics and structural relationships have been proposed such as using ontology learning method. This paper evaluates our previous work in ontology learning according to gold-standard evaluation approach in comparison to a notable state-of-the-art work and several baselines. The results show that our method is comparable to the state-of the art work which further validate our approach as has been previously validated using task-based evaluation approach.

  15. Unreliability and error in the military's "gold standard" measure of sexual harassment by education and gender.

    Science.gov (United States)

    Murdoch, Maureen; Pryor, John B; Griffin, Joan M; Ripley, Diane Cowper; Gackstetter, Gary D; Polusny, Melissa A; Hodges, James S

    2011-01-01

    The Department of Defense's "gold standard" sexual harassment measure, the Sexual Harassment Core Measure (SHCore), is based on an earlier measure that was developed primarily in college women. Furthermore, the SHCore requires a reading grade level of 9.1. This may be higher than some troops' reading abilities and could generate unreliable estimates of their sexual harassment experiences. Results from 108 male and 96 female soldiers showed that the SHCore's temporal stability and alternate-forms reliability was significantly worse (a) in soldiers without college experience compared to soldiers with college experience and (b) in men compared to women. For men without college experience, almost 80% of the temporal variance in SHCore scores was attributable to error. A plain language version of the SHCore had mixed effects on temporal stability depending on education and gender. The SHCore may be particularly ill suited for evaluating population trends of sexual harassment in military men without college experience.

  16. Partial verification bias and incorporation bias affected accuracy estimates of diagnostic studies for biomarkers that were part of an existing composite gold standard.

    Science.gov (United States)

    Karch, Annika; Koch, Armin; Zapf, Antonia; Zerr, Inga; Karch, André

    2016-10-01

    To investigate how choice of gold standard biases estimates of sensitivity and specificity in studies reassessing the diagnostic accuracy of biomarkers that are already part of a lifetime composite gold standard (CGS). We performed a simulation study based on the real-life example of the biomarker "protein 14-3-3" used for diagnosing Creutzfeldt-Jakob disease. Three different types of gold standard were compared: perfect gold standard "autopsy" (available in a small fraction only; prone to partial verification bias), lifetime CGS (including the biomarker under investigation; prone to incorporation bias), and "best available" gold standard (autopsy if available, otherwise CGS). Sensitivity was unbiased when comparing 14-3-3 with autopsy but overestimated when using CGS or "best available" gold standard. Specificity of 14-3-3 was underestimated in scenarios comparing 14-3-3 with autopsy (up to 24%). In contrast, overestimation (up to 20%) was observed for specificity compared with CGS; this could be reduced to 0-10% when using the "best available" gold standard. Choice of gold standard affects considerably estimates of diagnostic accuracy. Using the "best available" gold standard (autopsy where available, otherwise CGS) leads to valid estimates of specificity, whereas sensitivity is estimated best when tested against autopsy alone. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia.

    Science.gov (United States)

    Bismark, Andrew W; Thomas, Michael L; Tarasenko, Melissa; Shiluk, Alexandra L; Rackelmann, Sonia Y; Young, Jared W; Light, Gregory A

    2018-04-12

    Attentional dysfunction contributes to functional impairments in schizophrenia (SZ). Sustained attention is typically assessed via continuous performance tasks (CPTs), though many CPTs have limited cross-species translational validity and place demands on additional cognitive domains. A reverse-translated 5-Choice Continuous Performance Task (5C-CPT) for human testing-originally developed for use in rodents-was designed to minimize demands on perceptual, visual learning, processing speed, or working memory functions. To-date, no studies have validated the 5C-CPT against gold standard attentional measures nor evaluated how 5C-CPT scores relate to cognition in SZ. Here we examined the relationship between the 5C-CPT and the CPT-Identical Pairs (CPT-IP), an established and psychometrically robust measure of vigilance from the MATRICS Consensus Cognitive Battery (MCCB) in a sample of SZ patients (n = 35). Relationships to global and individual subdomains of cognition were also assessed. 5C-CPT and CPT-IP measures of performance (d-prime) were strongly correlated (r = 0.60). In a regression model, the 5C-CPT and CPT-IP collectively accounted for 54% of the total variance in MCCB total scores, and 27.6% of overall cognitive variance was shared between the 5C-CPT and CPT-IP. These results indicate that the reverse translated 5C-CPT and the gold standard CPT-IP index a common attentional construct that also significantly overlaps with variance in general cognitive performance. The use of simple, cross-species validated behavioral indices of attentional/cognitive functioning such as the 5C-CPT could accelerate the development of novel generalized pro-cognitive therapeutics for SZ and related neuropsychiatric disorders.

  18. Gold Standards,” Plurality and Monocultures: The Need for Diversity in Psychotherapy

    Directory of Open Access Journals (Sweden)

    Falk Leichsenring

    2018-04-01

    Full Text Available For psychotherapy of mental disorders, presently several approaches are available, such as interpersonal, humanistic, systemic, psychodynamic or cognitive behavior therapy (CBT. Pointing to the available evidence, proponents of CBT claim that CBT is the gold standard. Some authors even argue for an integrated CBT-based form of psychotherapy as the only form of psychotherapy. CBT undoubtedly has its strengths and CBT researchers have to be credited for developing and testing treatments for many mental disorders. A critical review, however, shows that the available evidence for the theoretical foundations of CBT, assumed mechanisms of change, quality of studies, and efficacy is not as robust as some researchers claim. Most important, there is no consistent evidence that CBT is more efficacious than other evidence-based approaches. These findings do not justify regarding CBT as the gold standard psychotherapy. They even provide less justification for the idea that the future of psychotherapy lies in one integrated CBT-based form of psychotherapy as the only type of psychotherapy. For the different psychotherapeutic approaches a growing body of evidence is available. These approaches have their strengths because of differences in their respective focus on interpersonal relationships, affects, cognitions, systemic perspectives, experiential, or unconscious processes. Different approaches may be suitable to different patients and therapists. As generally assumed, progress in research results from openness to new ideas and learning from diverse perspectives. Thus, different forms of evidence-based psychotherapy are required. Plurality is the future of psychotherapy, not a uniform “one fits all” approach.

  19. Quantitative Rapid Assessment of Leukoaraiosis in CT : Comparison to Gold Standard MRI.

    Science.gov (United States)

    Hanning, Uta; Sporns, Peter Bernhard; Schmidt, Rene; Niederstadt, Thomas; Minnerup, Jens; Bier, Georg; Knecht, Stefan; Kemmling, André

    2017-10-20

    The severity of white matter lesions (WML) is a risk factor of hemorrhage and predictor of clinical outcome after ischemic stroke; however, in contrast to magnetic resonance imaging (MRI) reliable quantification for this surrogate marker is limited for computed tomography (CT), the leading stroke imaging technique. We aimed to present and evaluate a CT-based automated rater-independent method for quantification of microangiopathic white matter changes. Patients with suspected minor stroke (National Institutes of Health Stroke scale, NIHSS < 4) were screened for the analysis of non-contrast computerized tomography (NCCT) at admission and compared to follow-up MRI. The MRI-based WML volume and visual Fazekas scores were assessed as the gold standard reference. We employed a recently published probabilistic brain segmentation algorithm for CT images to determine the tissue-specific density of WM space. All voxel-wise densities were quantified in WM space and weighted according to partial probabilistic WM content. The resulting mean weighted density of WM space in NCCT, the surrogate of WML, was correlated with reference to MRI-based WML parameters. The process of CT-based tissue-specific segmentation was reliable in 79 cases with varying severity of microangiopathy. Voxel-wise weighted density within WM spaces showed a noticeable correlation (r = -0.65) with MRI-based WML volume. Particularly in patients with moderate or severe lesion load according to the visual Fazekas score the algorithm provided reliable prediction of MRI-based WML volume. Automated observer-independent quantification of voxel-wise WM density in CT significantly correlates with microangiopathic WM disease in gold standard MRI. This rapid surrogate of white matter lesion load in CT may support objective WML assessment and therapeutic decision-making during acute stroke triage.

  20. Effectiveness of the gold standard programmes (GSP) for smoking cessation in pregnant and non-pregnant women

    DEFF Research Database (Denmark)

    Rasmussen, Mette; Heitmann, Berit Lilienthal; Tønnesen, Hanne

    2013-01-01

    Smoking is considered the most important preventable risk factor in relation to the development of complications during pregnancy and delivery. The aim of this study was to evaluate the effectiveness of an intensive 6-week gold standard programme (GSP) on pregnant women in real life....

  1. Can We Create a "Gold Standard of Education" for Our Children through the "Advancement via Independent Determination (AVID) Program"?

    Science.gov (United States)

    Gaskins, Darlene

    2014-01-01

    We need to come together as a team and become one system of total quality improvement regarding the education of our nation's children. In order to achieve a gold standard in the education of our nation's children, leadership has to be willing to go against the status quo and build bridges for long-term sustainable change. In order to survive,…

  2. Evaluating the Gold Standard: A Review and Meta-Analysis of the Structured Interview of Reported Symptoms

    Science.gov (United States)

    Green, Debbie; Rosenfeld, Barry

    2011-01-01

    The Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992) is often touted as the gold standard of measures of feigning. This label likely arises in part out of the impressive accuracy rates reported in the extensive validation research that preceded its publication. However, since its publication, researchers not only…

  3. Real-time PCR versus viral culture on urine as a gold standard in the diagnosis of congenital cytomegalovirus infection

    NARCIS (Netherlands)

    de Vries, Jutte J. C.; van der Eijk, Annemiek A.; Wolthers, Katja C.; Rusman, Lisette G.; Pas, Suzan D.; Molenkamp, Richard; Claas, Eric C.; Kroes, Aloys C. M.; Vossen, Ann C. T. M.

    2012-01-01

    Background: Cytomegalovirus (CMV) infection is the most common cause of congenital infection. Whereas CMV PCR has replaced viral culture and antigen detection in immunocompromised patients because of higher sensitivity, viral culture of neonatal urine is still referred to as the gold standard in the

  4. Grading School Choice: Evaluating School Choice Programs by the Friedman Gold Standard. School Choice Issues in Depth

    Science.gov (United States)

    Enlow, Robert C.

    2008-01-01

    In 2004, The Friedman Foundation for Educational Choice published a report titled "Grading Vouchers: Ranking America's School Choice Programs." Its purpose was to measure every existing school choice program against the gold standard set by Milton and Rose Friedman: that the most effective way to improve K-12 education and thus ensure a stable…

  5. Diagnostic tests for Helicobacter pylori : A prospective evaluation of their accuracy, without selecting a single test as the gold standard

    NARCIS (Netherlands)

    Thijs, J C; van Zwet, A A; Thijs, W J; Oey, H B; Karrenbeld, A; Stellaard, F; Luijt, D S; Meyer, B C; Kleibeuker, J H

    1996-01-01

    OBJECTIVE: To assess the accuracy of six commonly used diagnostic tests for Helicobacter pylori in a prospective study without using any specific test as the gold standard (the patient was regarded as H. pylori-infected if two or more tests, whatever their nature, were positive). METHODS: In 105

  6. Estimation of Sensitivity and Specificity of Three Conditionally Dependent Diagnostic Tests in the Absence of a Gold Standard

    NARCIS (Netherlands)

    Engel, B.; Swildens, B.; Stegeman, J.A.; Buist, W.G.; Jong, de M.

    2006-01-01

    This article presents a model to evaluate the accuracy of diagnostic tests. Data from three tests for the detection of EF-positive Streptococcus suis serotype 2 strains in sows were analyzed. The data were collected in a field study in the absence of a gold standard, that is, the true disease status

  7. SHORT- AND LONG-TERM BOND STRENGTHS OF A GOLD STANDARD

    Directory of Open Access Journals (Sweden)

    Safa TUNCER

    2015-04-01

    Full Text Available Purpose: The aim of this study was to investigate the micro tensile bond strength of a self-etch adhesive system following 1 year storage in water. Materials and Methods: 10 sound human molar teeth were used for micro tensile bond strength test. Twostep self-etch dentin adhesive (Clearfil SE Bond® was applied to the flat dentin surfaces according to the manufacturer’s instructions. Composite blocks (Z- 250; 3M ESPE of 5 mm in height have been prepared by using layering technique. Teeth were stored in water for 24 hours at 37°C and longitudinally sectioned to obtain dentin sticks of 1 mm2.Randomly selected samples from half of the teeth were immediately subjected to micro tensile test and. Remaining specimens were tested after 1 year storage in water. Bond strengths were calculated in megapascal (MPa. Results: Means and standard deviations of the Clearfil SE Bond® micro tensile bond strength values were, respectively, 37.31 ± 13.77 MPa and 24.78 ± 2.99 MPa after 24 h and 1 year of storage in water. The difference was statistically significant (p=0.031. Conclusion: Long-term storage in water decreased the micro tensile bond strength values of the twostep self-etch adhesive which has been accepted as the gold standard in bond strength tests.

  8. Standardization of radioactive gaseous waste radiation monitoring equipment from the International Electrotechnical Commission

    International Nuclear Information System (INIS)

    Fitoussi, L.

    1983-01-01

    After having introduced the works performed by the International Electrotechnical Commission, the authors report on the results of the studies carried out to achieve the standardization of the radiation monitoring equipment concerning the control of the gaseous waste from nuclear installations. The authors present the most interesting aspects of the regulations and recommendations, which include not only a description of the minimum permissible levels of sensitivity for the monitors, but also a description of the set of assays to be established in order to verify the level of performance of the monitors

  9. Evaluation of China's local enforcement of energy efficiency standards and labeling programs for appliances and equipment

    International Nuclear Information System (INIS)

    Khanna, Nina Zheng; Zhou, Nan; Fridley, David; Fino-Chen, Cecilia

    2013-01-01

    Aims: This paper aims to evaluate local enforcement of China's mandatory appliance and equipment energy efficiency standards and labeling programs, two increasingly important policies for meeting national energy and carbon reduction targets. The expected energy savings of efficiency standards and labels can be fully realized only with strong enforcement to ensure compliance for all products sold. This paper provides comprehensive retrospective evaluation of the methodologies, results, progress and remaining challenges in pilot enforcement projects initiated in the absence of consistent national check-testing focused on energy efficiency. Scope: This paper's scope is focused on 2006–2009 pilot local check-tests conducted to verify appliance and equipment compliance with China's mandatory energy label and efficiency standards. Conclusions: This paper finds both improvement and some backsliding in compliance rates over time. Compared to earlier efforts, 2009 check-tests covered a wider regional and product scope but demonstrated greater variation in compliance rates. Labeling display and energy efficiency compliance was generally high across regions and most products, but lower compliance rates were observed in less economically developed regions and for lighting and industrial products. Based on these findings, areas for improvement in local awareness, product sampling methodology, check-testing tools and procedures are identified. - Highlights: • China's mandatory standards and labeling crucial to national energy saving goals. • China's 2006–2009 pilot efficiency check-testing for standards and labeling evaluated. • Wider geographic and product scope in 2009, but greater variation in compliance. • Generally high compliance, but lower rates for less economically developed region. • Local check-test capacity improving but methodological challenges remain

  10. FASTBUS standard for development of the 4th generation fastresponse electronic equipment

    International Nuclear Information System (INIS)

    Basiladze, S.G.

    1982-01-01

    Design features are considered of a new FASTBUS electronic equipment developed for use as structural-logical and constructional base for multi-channel fast-response nuclear-physical measurement system of the fourth generation. A description is given of procedure of the data exchange between modules, ways of addressing (geographical, logical, broadcast transaction), acknowledgement of grant, controlling and informative registers, purpose of data-control buses and auxiliary logic, segment interconnect arrangement, organizat:on of interruptions and controlblock data transmission, arrangement of processor interfaces, snoop modules and diagnostics modules. A comparison between the FASTBUS standard and CAMAC system widely used nowadays shows that in the CAMAC standard the crate trunk and branch utilize quite different exchange logic, whereas in the FASTBUS standard it is unique. The CAMAC system cycle is strictly timed. The FASTBUS standard is not restricted for the module fast response, as it operates in the request-response mode. A conclusion is drawn to the effect that the FASTBUS standard advantages are most fully realized in on-line processing of large volumes of initial data

  11. Challenges of equipment qualification using today`s standards with emphasis on a class 1E motor program

    Energy Technology Data Exchange (ETDEWEB)

    Deaton, K.

    1995-02-01

    This paper describes qualification of new equipment for safety related service in the nuclear power industry in accordance with current industry standards. This topic is presented from the perspective of an original equipment manufacturer J(OEM). Equipment qualification is first discussed in a general way then an example is provided of an electric motor qualification. A review of alternative qualification methods including commercial dedication is included. Potential difficulties with alternative/expedited qualification methods are also discussed.

  12. 40 CFR 60.254 - Standards for coal processing and conveying equipment, coal storage systems, transfer and loading...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standards for coal processing and conveying equipment, coal storage systems, transfer and loading systems, and open storage piles. 60.254... (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Coal Preparation...

  13. Population Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets

    Directory of Open Access Journals (Sweden)

    Ohno Summer

    2011-08-01

    Full Text Available Abstract Background Verbal autopsy methods are critically important for evaluating the leading causes of death in populations without adequate vital registration systems. With a myriad of analytical and data collection approaches, it is essential to create a high quality validation dataset from different populations to evaluate comparative method performance and make recommendations for future verbal autopsy implementation. This study was undertaken to compile a set of strictly defined gold standard deaths for which verbal autopsies were collected to validate the accuracy of different methods of verbal autopsy cause of death assignment. Methods Data collection was implemented in six sites in four countries: Andhra Pradesh, India; Bohol, Philippines; Dar es Salaam, Tanzania; Mexico City, Mexico; Pemba Island, Tanzania; and Uttar Pradesh, India. The Population Health Metrics Research Consortium (PHMRC developed stringent diagnostic criteria including laboratory, pathology, and medical imaging findings to identify gold standard deaths in health facilities as well as an enhanced verbal autopsy instrument based on World Health Organization (WHO standards. A cause list was constructed based on the WHO Global Burden of Disease estimates of the leading causes of death, potential to identify unique signs and symptoms, and the likely existence of sufficient medical technology to ascertain gold standard cases. Blinded verbal autopsies were collected on all gold standard deaths. Results Over 12,000 verbal autopsies on deaths with gold standard diagnoses were collected (7,836 adults, 2,075 children, 1,629 neonates, and 1,002 stillbirths. Difficulties in finding sufficient cases to meet gold standard criteria as well as problems with misclassification for certain causes meant that the target list of causes for analysis was reduced to 34 for adults, 21 for children, and 10 for neonates, excluding stillbirths. To ensure strict independence for the validation of

  14. Performances of Four Helicobacter pylori Serological Detection Kits Using Stool Antigen Test as Gold Standard.

    Science.gov (United States)

    Biranjia-Hurdoyal, Susheela D; Seetulsingh-Goorah, Sharmila P

    2016-01-01

    The aim was to determine the performances of four Helicobacter pylori serological detection kits in different target groups, using Amplified IDEIA™ Hp StAR™ as gold standard. Kits studied were Rapid Immunochromatoghraphic Hexagon, Helicoblot 2.1, an EIA IgG kit and EIA IgA kit. Stool and blood samples were collected from 162 apparently healthy participants (control) and 60 Type 2 diabetes mellitus (T2DM) patients. The performances of the four serological detection kits were found to be affected by gender, age, health status and ethnicity of the participants. In the control group, the Helicoblot 2.1 kit had the best performance (AUC = 0.85; ppoor performances. In the T2DM subgroup, the kits H2.1 and EIA IgG had best performances, with accuracies of 96.5% and 93.1% respectively. The performance of EIA IgG improved with adjustment of its cut-off value. The performances of the detection kits were affected by various factors which should be taken into consideration.

  15. Performances of Four Helicobacter pylori Serological Detection Kits Using Stool Antigen Test as Gold Standard.

    Directory of Open Access Journals (Sweden)

    Susheela D Biranjia-Hurdoyal

    Full Text Available The aim was to determine the performances of four Helicobacter pylori serological detection kits in different target groups, using Amplified IDEIA™ Hp StAR™ as gold standard. Kits studied were Rapid Immunochromatoghraphic Hexagon, Helicoblot 2.1, an EIA IgG kit and EIA IgA kit.Stool and blood samples were collected from 162 apparently healthy participants (control and 60 Type 2 diabetes mellitus (T2DM patients.The performances of the four serological detection kits were found to be affected by gender, age, health status and ethnicity of the participants. In the control group, the Helicoblot 2.1 kit had the best performance (AUC = 0.85; p<0.05, accuracy = 86.4%, followed by EIA IgG (AUC = 0.75; p<0.05, accuracy = 75.2%. The Rapid Hexagon and EIA IgA kits had relatively poor performances. In the T2DM subgroup, the kits H2.1 and EIA IgG had best performances, with accuracies of 96.5% and 93.1% respectively. The performance of EIA IgG improved with adjustment of its cut-off value.The performances of the detection kits were affected by various factors which should be taken into consideration.

  16. The free electron laser: a system capable of determining the gold standard in laser vision correction

    International Nuclear Information System (INIS)

    Fowler, W. Craig; Rose, John G.; Chang, Daniel H.; Proia, Alan D.

    1999-01-01

    Introduction. In laser vision correction surgery, lasers are generally utilized based on their beam-tissue interactions and corneal absorption characteristics. Therefore, the free electron laser, with its ability to provide broad wavelength tunability, is a unique research tool for investigating wavelengths of possible corneal ablation. Methods. Mark III free electron laser wavelengths between 2.94 and 6.7 μm were delivered in serial 0.1 μm intervals to corneas of freshly enucleated porcine globes. Collateral damage, ablation depth, and ablation diameter were measured in histologic sections. Results. The least collateral damage (12-13 μm) was demonstrated at three wavelengths: 6.0, 6.1 (amide I), and 6.3 μm. Minimal collateral damage (15 μm) was noted at 2.94 μm (OH-stretch) and at 6.2 μm. Slightly greater collateral damage was noted at 6.45 μm (amide II), as well as at the 5.5-5.7 μm range, but this was still substantially less than the collateral damage noted at the other wavelengths tested. Conclusions. Our results suggest that select mid-infrared wavelengths have potential for keratorefractive surgery and warrant additional study. Further, the free electron laser's ability to allow parameter adjustment in the far-ultraviolet spectrum may provide unprecedented insights toward establishing the gold-standard parameters for laser vision correction surgery

  17. The Cox-maze IV procedure in its second decade: still the gold standard?

    Science.gov (United States)

    Ruaengsri, Chawannuch; Schill, Matthew R; Khiabani, Ali J; Schuessler, Richard B; Melby, Spencer J; Damiano, Ralph J

    2018-04-01

    Atrial fibrillation (AF) is the most common cardiac arrhythmia and the treatment options include medical treatment and catheter-based or surgical interventions. AF is a major cause of stroke, and its prevalence is increasing. The surgical treatment of AF has been revolutionized over the past 2 decades through surgical innovation and improvements in endoscopic imaging, ablation technology and surgical instrumentation. The Cox-maze (CM) procedure, which was developed by James Cox and introduced clinically in 1987, is a procedure in which multiple incisions are created in both the left and the right atria to eliminate AF while allowing the sinus impulse to reach the atrioventricular node. This procedure became the gold standard for the surgical treatment of AF. Its latest iteration is termed the CM IV and was introduced in 2002. The CM IV replaced the previous cut-and-sew method (CM III) by replacing most of the incisions with a combination of bipolar radiofrequency and cryoablation. The use of ablation technologies, made the CM IV technically easier, faster and more amenable to minimally invasive approaches. The aims of this article are to review the indications and preoperative planning for the CM IV, to describe the operative technique and to review the literature including comparisons of the CM IV with the previous cut-and-sew method. Finally, this review explores future directions for the surgical treatment of patients with AF.

  18. Open Partial Nephrectomy in Renal Cancer: A Feasible Gold Standard Technique in All Hospitals

    Directory of Open Access Journals (Sweden)

    J. M. Cozar

    2008-01-01

    Full Text Available Introduction. Partial nephrectomy (PN is playing an increasingly important role in localized renal cell carcinoma (RCC as a true alternative to radical nephrectomy. With the greater experience and expertise of surgical teams, it has become an alternative to radical nephrectomy in young patients when the tumor diameter is 4 cm or less in almost all hospitals since cancer-specific survival outcomes are similar to those obtained with radical nephrectomy. Materials and Methods. The authors comment on their own experience and review the literature, reporting current indications and outcomes including complications. The surgical technique of open partial nephrectomy is outlined. Conclusions. Nowadays, open PN is the gold standard technique to treat small renal masses, and all nonablative techniques must pass the test of time to be compared to PN. It is not ethical for patients to undergo radical surgery just because the urologists involved do not have adequate experience with PN. Patients should be involved in the final treatment decision and, when appropriate, referred to specialized centers with experience in open or laparoscopic partial nephrectomies.

  19. Designing electronic equipment on the basis of standard mechanical structures using internet re­sour­ces

    Directory of Open Access Journals (Sweden)

    Karlangach A. P.

    2016-12-01

    Full Text Available The author proposes a method to design electronic equipment based on functional-node design method that involves the use of 2D- and 3D- models mechanical structures for electronic equipment as a way to reduce development time and errors when creating design documentation for electronic equipment. At present, most areas of science and technology are computerized, more problems in designing electronic equipment are dealt with using computer-aided design (CAD and Computer-aided manufacturing (CAM to reduce the time required for development and manufacturing of electronic equipment. Development of design documentation also requires a more effective approach, because the less the time for development of the design documentation is, the faster the developed device will go into production. The aim of the study is to develop a method of designing electronic equipment using 2D and 3D models of standard mechanical structures for electronic equipment using Internet resources. Based on the presented methods is an example of designing a device from standard bearing structures. Compared with traditional technology, the method of designing electronic equipment using standard parts has the following advantages: - reduces time and improves quality of development through the use of existing design documentation; - accelerates the implementation and introducing into production processes; - increases unification of design solutions.

  20. Gold-coated copper cone detector as a new standard detector for F2 laser radiation at 157 nm

    International Nuclear Information System (INIS)

    Kueck, Stefan; Brandt, Friedhelm; Taddeo, Mario

    2005-01-01

    A new standard detector for high-accuracy measurements of F2 laser radiation at 157 nm is presented. This gold-coated copper cone detector permits the measurement of average powers up to 2 W with an uncertainty of ∼1%. To the best of our knowledge, this is the first highly accurate standard detector for F2 laser radiation for this power level. It is fully characterized according to Guide to the Expression of Uncertainty in Measurement of the International Organization for Standardization and is connected to the calibration chain for laser radiation established by the German National Metrology Institute

  1. Energy-efficiency labels and standards: A guidebook for appliances, equipment and lighting

    Energy Technology Data Exchange (ETDEWEB)

    McMahon, James E.; Wiel, Stephen

    2001-02-16

    Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and the United Nations Foundation (UNF) recognize the need to support policy makers in their efforts to implement energy-efficiency standards and labeling programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This guidebook was prepared over the course of the past year with significant contribution from the authors and reviewers mentioned previously. Their diligent participation has made this the international guidance tool it was intended to be. The lead authors would also like to thank the following individuals for their support in the development, production, and distribution of the guidebook: Marcy Beck, Elisa Derby, Diana Dhunke, Ted Gartner, and Julie Osborn of Lawrence Berkeley National Laboratory as well as Anthony Ma of Bevilacqua-Knight, Inc. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards-setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design, development, implementation, maintenance, and evaluation of the

  2. In search for a gold-standard procedure to count motor neurons in the spinal cord.

    Science.gov (United States)

    Ferrucci, Michela; Lazzeri, Gloria; Flaibani, Marina; Biagioni, Francesca; Cantini, Federica; Madonna, Michele; Bucci, Domenico; Limanaqi, Fiona; Soldani, Paola; Fornai, Francesco

    2018-03-14

    Counting motor neurons within the spinal cord and brainstem represents a seminal step to comprehend the anatomy and physiology of the final common pathway sourcing from the CNS. Motor neuron loss allows to assess the severity of motor neuron disorders while providing a tool to assess disease modifying effects. Counting motor neurons at first implies gold standard identification methods. In fact, motor neurons may occur within mixed nuclei housing a considerable amount of neurons other than motor neurons. In the present review, we analyse various approaches to count motor neurons emphasizing both the benefits and bias of each protocol. A special emphasis is placed on discussing automated stereology. When automated stereology does not take into account site-specificity and does not distinguish between heterogeneous neuronal populations, it may confound data making such a procedure a sort of "guide for the perplex". Thus, if on the one hand automated stereology improves our ability to quantify neuronal populations, it may also hide false positives/negatives in neuronal counts. For instance, classic staining for antigens such as SMI-32, SMN and ChAT, which are routinely considered to be specific for motor neurons, may also occur in other neuronal types of the spinal cord. Even site specificity within Lamina IX may be misleading due to neuronal populations having a size and shape typical of motor neurons. This is the case of spinal border cells, which often surpass the border of Lamina VII and intermingle with motor neurons of Lamina IX. The present article discusses the need to join automated stereology with a dedicated knowledge of each specific neuroanatomical setting.

  3. De-identifying Swedish clinical text - refinement of a gold standard and experiments with Conditional random fields

    Directory of Open Access Journals (Sweden)

    Dalianis Hercules

    2010-04-01

    Full Text Available Abstract Background In order to perform research on the information contained in Electronic Patient Records (EPRs, access to the data itself is needed. This is often very difficult due to confidentiality regulations. The data sets need to be fully de-identified before they can be distributed to researchers. De-identification is a difficult task where the definitions of annotation classes are not self-evident. Results We present work on the creation of two refined variants of a manually annotated Gold standard for de-identification, one created automatically, and one created through discussions among the annotators. The data is a subset from the Stockholm EPR Corpus, a data set available within our research group. These are used for the training and evaluation of an automatic system based on the Conditional Random Fields algorithm. Evaluating with four-fold cross-validation on sets of around 4-6 000 annotation instances, we obtained very promising results for both Gold Standards: F-score around 0.80 for a number of experiments, with higher results for certain annotation classes. Moreover, 49 false positives that were verified true positives were found by the system but missed by the annotators. Conclusions Our intention is to make this Gold standard, The Stockholm EPR PHI Corpus, available to other research groups in the future. Despite being slightly more time-consuming we believe the manual consensus gold standard is the most valuable for further research. We also propose a set of annotation classes to be used for similar de-identification tasks.

  4. The accuracy of k1-standardized INAA applied to a gold-lined well-type detector

    International Nuclear Information System (INIS)

    Blaauw, M.

    2000-01-01

    The k 1 -method for standardization in INAA specifically tackles the problem of the interpretation of gamma-ray spectra as obtained with highly efficient detectors, as opposed to the k 0 -method. Results obtained from three NIST reference materials, measured after neutron activation with a gold-lined well-type detector, are presented. It is concluded that the accuracy of the method is better than 1%. (author)

  5. Thrombelastography detects dabigatran at therapeutic concentrations in vitro to the same extent as gold-standard tests

    DEFF Research Database (Denmark)

    Solbeck, Sacha; Ostrowski, Sisse R; Stensballe, Jakob

    2016-01-01

    BACKGROUND/OBJECTIVES: Dabigatran is an oral anticoagulant approved for treatment of non-valvular atrial fibrillation, deep venous thrombosis (DVT), pulmonary embolism and prevention of DVT following orthopedic surgery. Monitoring of the dabigatran level is essential in trauma and bleeding patien...... to the current gold-standard tests Hemoclot and ECT, for assessing dabigatran. TEG R is applicable as a rapid and precise whole blood monitoring test for dabigatran treated patients in the emergency setting....

  6. Practical no-gold-standard evaluation framework for quantitative imaging methods: application to lesion segmentation in positron emission tomography.

    Science.gov (United States)

    Jha, Abhinav K; Mena, Esther; Caffo, Brian; Ashrafinia, Saeed; Rahmim, Arman; Frey, Eric; Subramaniam, Rathan M

    2017-01-01

    Recently, a class of no-gold-standard (NGS) techniques have been proposed to evaluate quantitative imaging methods using patient data. These techniques provide figures of merit (FoMs) quantifying the precision of the estimated quantitative value without requiring repeated measurements and without requiring a gold standard. However, applying these techniques to patient data presents several practical difficulties including assessing the underlying assumptions, accounting for patient-sampling-related uncertainty, and assessing the reliability of the estimated FoMs. To address these issues, we propose statistical tests that provide confidence in the underlying assumptions and in the reliability of the estimated FoMs. Furthermore, the NGS technique is integrated within a bootstrap-based methodology to account for patient-sampling-related uncertainty. The developed NGS framework was applied to evaluate four methods for segmenting lesions from F-Fluoro-2-deoxyglucose positron emission tomography images of patients with head-and-neck cancer on the task of precisely measuring the metabolic tumor volume. The NGS technique consistently predicted the same segmentation method as the most precise method. The proposed framework provided confidence in these results, even when gold-standard data were not available. The bootstrap-based methodology indicated improved performance of the NGS technique with larger numbers of patient studies, as was expected, and yielded consistent results as long as data from more than 80 lesions were available for the analysis.

  7. Underestimation of Self-Reported Smoking Prevalence in Korean Adolescents: Evidence from Gold Standard by Combined Method.

    Science.gov (United States)

    Hwang, Jun Hyun; Kim, Jong Yeon; Lee, Do Hoon; Jung, Hye Gyoun; Park, Soon-Woo

    2018-04-05

    The objective of this study was to evaluate the validity of self-reported smoking prevalence in Korean adolescents by using an improved gold standard by a combined method. Using a stratified sampling method, we selected 13 schools from among 397 high schools that participated in the 2015 Korean Youth Health Risk Behavior Web-Based Survey (KYRBS). A second survey (repeated self-reporting questionnaire and urinary cotinine test) was conducted on 1058 students who completed the KYRBS. The gold standard of current smoker was defined as those either self-reporting as a smoker in the second survey or having a urinary cotinine concentration ≥50 ng/mL. The current smoking prevalence in the first survey (KYRBS) was 7.9% (boys 16.5% and girls 1.8%), which was lower than the results based on gold standard (11.3% total, boys 21.9% and girls 3.7%). The sensitivity and specificity of self-reported smoking status was 62.5% and 99.0%, respectively. In particular, the sensitivity of girls (43.5%) was lower than that of boys (67.0%). The self-reported smoking prevalence in Korean adolescents was underestimated, particularly among girls. Careful attention should be paid to interpreting adolescents' smoking prevalence, and supplementary surveys or periodic validity tests need to be considered in Asian countries.

  8. Application of Pressure Equipment Standard at nuclear power plants; Aplicacion del Reglamento de Equipos a Presion a las centrales nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Mostaza, J. M.

    2011-07-01

    Regarding with the paper presented on 9{sup t}h June 2011 referred to the Industrial Security standard in Nuclear Plants, it was about the application of Pressure Equipment standard to mentioned Nuclear Plants, this article is an extract of the paper going to be exposed. (Author)

  9. Comparison and Analysis of IEEE 344 and IEC 60980 standards for harmonization of seismic qualification of safety-related equipment

    International Nuclear Information System (INIS)

    Lee, Young Ok; Kim, Jong Seog; Seo, Jeong Ho; Kim, Myung Jun

    2011-01-01

    The seismic qualification of safety related equipment in nuclear power plants should demonstrate an equipment's ability to perform its safety function during/or after the time it is subjected to the forces resulting from one SSE. In addition, the equipment must withstand the effects of a number of OBEs, preceding the SSE. IEEE 344 and IEC 60980 present the criteria for establishing procedures demonstrating that the Class 1E equipment can meet its performance requirement during seismic events. Currently, IEEE 344 is used for regulation of nuclear power plant in the United State whereas IEC 60980 is mainly used in Europe. In particular, NPPs of France and China apply with RCC-E and GB that are domestic standards, respectively. Equipment supplier and Utility have difficulties because of different applicable standards. Equipment supplier to export S/R components/equipment to other standard area performs additional seismic qualification. For example, equipment are qualifies according to IEC 60980, RCC-E, GB although they have been qualified in accordance with IEEE 344. Also, utility to attempt power up-rate, life extension of NPP constructed under rules of RCC-E such as Ulchin NPP 1 and 2 has similar difficulties. RCC-E endorses IEC 60980 and GB is almost same as IEC 60980 except minor difference of earthquake environment definition. Therefore this paper surveys the similarities and differences between IEEE 344 and IEC 60980. In addition, this paper considers how the two sets of standards may be used in a complementary fashion to be possible using one or the other standard area

  10. Efficiency of a solid-phase chemiluminescence immunoassay for detection of antinuclear and cytoplasmic autoantibodies compared with gold standard immunoprecipitation.

    Science.gov (United States)

    Gelpí, Carmen; Pérez, Elena; Roldan, Cristina

    2014-09-01

    The aim of this study was to compare the degree of agreement of a novel Zenit RA chemiluminescent immunoassay (CLIA) from A. Menarini Diagnostics (Florence, Italy) and the gold standard immunoprecipitation assay to screen for the presence of specific anti-U1snRNP, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, anti-Jo-1((his)tRNA-Synthetase) and anti-Scl-70(Topo I) antibodies. We studied 114 sera, 98 from patients with well-defined autoimmune connective tissue diseases and 16 from blood donor volunteers. All samples were fully characterized using the new chemiluminescent immunoassay and immunoprecipitation. In addition, all the samples were analyzed by indirect immunofluorescence (IIF) and anti-Scl-70(Topo I) antibodies were analyzed by immunoblot (IB) assay. Discrepant samples were analyzed using a commercial dot blot technique (Recomline from Mikrogen). The simple Kappa coefficient was used to measure the level of agreement between the results of Zenit RA CLIA and the gold standard. The Kappa agreement between Zenit RA CLIA and gold standard immunoprecipitation, as well as IB and IIFassays for the presence of anti-Scl-70(Topo I)(0.948) was excellent. The concordance between Zenit RA CLIA and gold standard immunoprecipitation for the presence of anti-U1snRNP (0.883), anti-Ro/SS-A (0.878), anti-Jo-1((his)tRNA-Synthetase) (0.791) and anti-Sm (0.786) was good, and excellent when the cut-off was raised to 14 U/ml (arbitrary units/ml). Between Zenit RA CLIA and gold standard immunoprecipitation for the presence of anti-La/SS-B, the Kappa agreement had a value of 0.689, but this improved to 0.775 when the cut-off was raised to14 U/ml. Precision was good based on the evaluation of replicate samples. Inter-assay coefficient variation was lower than 3.4 % (CV in %) in all the kits and <1.2 % (CV in  %) for intra-assay measurements. Our findings show that Zenit RA CLIA was specific and sensitive to detect anti-U1snRNP, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, anti-Jo-1((his

  11. An investigation into the validity of cervical spine motion palpation using subjects with congenital block vertebrae as a 'gold standard'

    Directory of Open Access Journals (Sweden)

    Peterson Cynthia K

    2004-06-01

    Full Text Available Abstract Background Although the effectiveness of manipulative therapy for treating back and neck pain has been demonstrated, the validity of many of the procedures used to detect joint dysfunction has not been confirmed. Practitioners of manual medicine frequently employ motion palpation as a diagnostic tool, despite conflicting evidence regarding its utility and reliability. The introduction of various spinal models with artificially introduced 'fixations' as an attempt to introduce a 'gold standard' has met with frustration and frequent mechanical failure. Because direct comparison against a 'gold standard' allows the validity, specificity and sensitivity of a test to be calculated, the identification of a realistic 'gold standard' against which motion palpation can be evaluated is essential. The objective of this study was to introduce a new, realistic, 'gold standard', the congenital block vertebra (CBV to assess the validity of motion palpation in detecting a true fixation. Methods Twenty fourth year chiropractic students examined the cervical spines of three subjects with single level congenital block vertebrae, using two commonly employed motion palpation tests. The examiners, who were blinded to the presence of congenital block vertebrae, were asked to identify the most hypomobile segment(s. The congenital block segments included two subjects with fusion at the C2–3 level and one with fusion at C5-6. Exclusion criteria included subjects who were frankly symptomatic, had moderate or severe degenerative changes in their cervical spines, or displayed signs of cervical instability. Spinal levels were marked on the subject's skin overlying the facet joints from C1 to C7 bilaterally and the motion segments were then marked alphabetically with 'A' corresponding to C1-2. Kappa coefficients (K were calculated to determine the validity of motion palpation to detect the congenitally fused segments as the 'most hypomobile' segments. Sensitivity

  12. The restoration of the gold standard after the US Civil War : A volatility analysis

    NARCIS (Netherlands)

    Meulemann, Max; Uebele, Martin; Wilfling, Bernd

    This paper presents a new view on the gold price of greenbacks during and after the American Civil War by analyzing exchange-rate volatility rather than exchange-rate levels. Our empirical investigation detects regimes of high and low volatility alternating in a way that is consistent with a

  13. 75 FR 22469 - National Emission Standards for Hazardous Air Pollutants: Gold Mine Ore Processing and Production...

    Science.gov (United States)

    2010-04-28

    ... facilities use a different, zinc precipitate process, which is described later in this preamble. At all the... zinc powder (discussed below). Separation of gold through electrowinning is achieved by using an... poured into bars, and any flux slag that hardens on the bars is removed with a mechanical chipper. The...

  14. Does the Gold Standard label hold its promise in delivering higher Sustainable Development benefits? A multi-criteria comparison of CDM projects

    International Nuclear Information System (INIS)

    Drupp, Moritz A.

    2011-01-01

    The Clean Development Mechanism (CDM) has a twin objective: to help developed countries reduce GHG emissions, and to support developing countries in achieving Sustainable Development (SD). As a response to the widespread criticism of the CDM's unsatisfactory SD record, initiatives have developed premium labels like the Gold Standard, which applies two additional 'screens' to filter CDM projects for higher SD benefits. In order to determine whether Gold Standard projects can be associated with higher local SD benefits, this paper evaluates the potential benefits of 48 CDM projects using a multi-criteria method and building on existing work. The 18 evaluated Gold Standard projects are compared to a 'representative portfolio' of 30 unlabeled CDM projects in order to capture the 'full' effect of the additional Gold Standard requirements, which is further decomposed into the two 'screen' effects. The results suggest that Gold Standard Certified Emission Reductions can be associated with higher potential local SD benefits when compared to the 'representative portfolio' of unlabeled CDM projects, while the comparison of projects of the same type remains inconclusive. The results support previous findings showing that renewable energy projects may deliver comparatively high SD benefits. - Research highlights: → This study evaluates and compares the potential contribution of unlabeled- and Gold Standard labeled CDM projects to Sustainable Development (SD), extending the previously assessed projects as well as the methodological approach. → Gold Standard labeled Certified Emission Reductions (CER) can be associated with higher potential SD benefits compared to unlabeled projects. → A decomposition analysis shows that the Gold Standard s SD surplus must be primarily attributed to the favorable contribution of renewable energy projects to SD. → Policy makers might thus shift incentives towards renewable energy projects and buyers of CERs may shift their offset

  15. Use of gold and silver standards based on phenol-formalde-hyde resin in assay-activation analysis of geological samples

    International Nuclear Information System (INIS)

    Aliev, A.I.; Drynkin, V.I.; Lejpunskaya, D.I.; Nedostup, T.V.

    1976-01-01

    Using standards on phenol-formaldehyde resin base for assaying-activation analysis of geological specimens for gold and silver has bee the advantage of uniformly distributing Au and Ag in spesimens and possible preparing tablets of practically any form or size. The validity and accuracy of these standards have been studied for the cases of short irradiation. Conventional point standards were used as reference standards. The experiments carried out have shown that tablet resol standards are suitable for a mass assaying-activation analysis for gold and silver at practically any concentrations

  16. The Tanzania experience: clinical laboratory testing harmonization and equipment standardization at different levels of a tiered health laboratory system.

    Science.gov (United States)

    Massambu, Charles; Mwangi, Christina

    2009-06-01

    The rapid scale-up of the care and treatment programs in Tanzania during the preceding 4 years has greatly increased the demand for quality laboratory services for diagnosis of HIV and monitoring patients during antiretroviral therapy. Laboratory services were not in a position to cope with this demand owing to poor infrastructure, lack of human resources, erratic and/or lack of reagent supply and commodities, and slow manual technologies. With the limited human resources in the laboratory and the need for scaling up the care and treatment program, it became necessary to install automated equipment and train personnel for the increased volume of testing and new tests across all laboratory levels. With the numerous partners procuring equipment, the possibility of a multitude of equipment platforms with attendant challenges for procurement of reagents, maintenance of equipment, and quality assurance arose. Tanzania, therefore, had to harmonize laboratory tests and standardize laboratory equipment at different levels of the laboratory network. The process of harmonization of tests and standardization of equipment included assessment of laboratories, review of guidelines, development of a national laboratory operational plan, and stakeholder advocacy. This document outlines this process.

  17. Gold Returns

    OpenAIRE

    Robert J. Barro; Sanjay P. Misra

    2013-01-01

    From 1836 to 2011, the average real rate of price change for gold in the United States is 1.1% per year and the standard deviation is 13.1%, implying a one-standard-deviation confidence band for the mean of (0.1%, 2.1%). The covariances of gold's real rate of price change with consumption and GDP growth rates are small and statistically insignificantly different from zero. These negligible covariances suggest that gold's expected real rate of return--which includes an unobserved dividend yiel...

  18. Effectiveness of the Gold Standard Programme compared with other smoking cessation interventions in Denmark: a cohort study.

    Science.gov (United States)

    Rasmussen, Mette; Fernández, Esteve; Tønnesen, Hanne

    2017-02-27

    We compared the effectiveness of the Gold Standard Programme (a comprehensive smoking cessation intervention commonly used in Denmark) with other face-to-face smoking cessation programmes in Denmark after implementation in real life, and we identified factors associated with successful quitting. Prospective cohort study. A total of 423 smoking cessation clinics from different settings reported data from 2001 to 2013. In total, 82 515 patients were registered. Smokers ≥15 years old and attending a programme with planned follow-up were included. Smokers who did not want further contact, who intentionally were not followed up or who lacked information about the intervention they received were excluded. A total of 46 287 smokers were included. Various real-life smoking cessation interventions were identified and compared: The Gold Standard Programme, Come & Quit, crash courses, health promotion counselling (brief intervention) and other interventions. Self-reported continuous abstinence for 6 months. Overall, 33% (11 184) were continuously abstinent after 6 months; this value was 24% when non-respondents were considered smokers. The follow-up rate was 74%. Women were less likely to remain abstinent, OR 0.83 (CI 0.79 to 0.87). Short interventions were more effective among men. After adjusting for confounders, the Gold Standard Programme was the only intervention with significant results across sex, increasing the odds of abstinence by 69% for men and 31% for women. In particular, compliance, and to a lesser degree, mild smoking, older age and not being disadvantaged were associated with positive outcomes for both sexes. Compliance increased the odds of abstinence more than 3.5-fold. Over time, Danish smoking cessation interventions have been effective in real life. Compliance is the main predictor of successful quitting. Interestingly, short programmes seem to have relatively strong effects among men, but the absolute numbers are very small. Only the

  19. Imaging of the optic disk in caring for patients with glaucoma: ophthalmoscopy and photography remain the gold standard.

    Science.gov (United States)

    Spaeth, George L; Reddy, Swathi C

    2014-01-01

    Optic disk imaging is integral to the diagnosis and treatment of patients with glaucoma. We discuss the various forms of imaging the optic nerve, including ophthalmoscopy, photography, and newer imaging modalities, including optical coherence tomography (OCT), confocal scanning laser ophthalmoscopy (HRT), and scanning laser polarimetry (GDx), specifically highlighting their benefits and disadvantages. We argue that ophthalmoscopy and photography remain the gold standard of imaging due to portability, ease of interpretation, and the presence of a large database of images for comparison. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Standard on fire protection for self-propelled and mobile surface mining equipment. 2001 ed.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Safeguard life and property against fire and related hazards in mines with the latest requirements in NFPA 121. This 2001 edition covers fire detection, suppression, ignition sources, fire risk assessment and maintenance of mining equipment systems. 4 apps.

  1. Comparison of EHR-based diagnosis documentation locations to a gold standard for risk stratification in patients with multiple chronic conditions.

    Science.gov (United States)

    Martin, Shelby; Wagner, Jesse; Lupulescu-Mann, Nicoleta; Ramsey, Katrina; Cohen, Aaron; Graven, Peter; Weiskopf, Nicole G; Dorr, David A

    2017-08-02

    To measure variation among four different Electronic Health Record (EHR) system documentation locations versus 'gold standard' manual chart review for risk stratification in patients with multiple chronic illnesses. Adults seen in primary care with EHR evidence of at least one of 13 conditions were included. EHRs were manually reviewed to determine presence of active diagnoses, and risk scores were calculated using three different methodologies and five EHR documentation locations. Claims data were used to assess cost and utilization for the following year. Descriptive and diagnostic statistics were calculated for each EHR location. Criterion validity testing compared the gold standard verified diagnoses versus other EHR locations and risk scores in predicting future cost and utilization. Nine hundred patients had 2,179 probable diagnoses. About 70% of the diagnoses from the EHR were verified by gold standard. For a subset of patients having baseline and prediction year data (n=750), modeling showed that the gold standard was the best predictor of outcomes on average for a subset of patients that had these data. However, combining all data sources together had nearly equivalent performance for prediction as the gold standard. EHR data locations were inaccurate 30% of the time, leading to improvement in overall modeling from a gold standard from chart review for individual diagnoses. However, the impact on identification of the highest risk patients was minor, and combining data from different EHR locations was equivalent to gold standard performance. The reviewer's ability to identify a diagnosis as correct was influenced by a variety of factors, including completeness, temporality, and perceived accuracy of chart data.

  2. Slim 198gold-grain implanter loaded with standard royal marsden 14-grain magazines

    International Nuclear Information System (INIS)

    Delclos, L.; Moore, E.B.

    1979-01-01

    We designed a slim gold-grain implanter with adaptable lengths to implant areas accessible only through long, narrow, examining instruments, such as a suspension laryngoscope. The implanter is loaded with the same 14-grain magazine designed for and supplied with the Royal Marsden gun. The simplicity of the loading mechanism with a minimum of moving parts makes the instrument practically trouble free. Although it is designed to be used along narrow examining instruments, it can also be used in any situation in which a permanent implant is required, for instance, prostatic cancer and pelvic recurrences in cancer of the uterine cervix previously treated by external and intracavitary irradiation

  3. Testing Pneumonia Vaccines in the Elderly: Determining a Case Definition for Pneumococcal Pneumonia in the Absence of a Gold Standard.

    Science.gov (United States)

    Jokinen, Jukka; Snellman, Marja; Palmu, Arto A; Saukkoriipi, Annika; Verlant, Vincent; Pascal, Thierry; Devaster, Jeanne-Marie; Hausdorff, William P; Kilpi, Terhi M

    2017-12-15

    Clinical assessments of vaccines to prevent pneumococcal (Pnc) community-acquired pneumonia (CAP) require sensitive and specific case definitions, but there is no gold standard diagnostic test. To develop a new case definition suitable for vaccine efficacy studies, we applied latent class analysis (LCA) to the results from seven diagnostic tests for Pnc etiology on clinical specimens from 323 elderly radiologically-confirmed pneumonia cases enrolled in The Finnish Community-Acquired Pneumonia Epidemiology study during 2005-2007. Compared to the conventional use of LCA, which is mainly to determine sensitivities and specificities of different tests, we instead used LCA as an appropriate instrument to predict the probability of Pnc etiology for each CAP case based on their test profiles, and utilized the predictions to minimize the sample size that would be needed for a vaccine efficacy trial. When compared to the conventional laboratory criteria of encapsulated Pnc in blood culture or in high-quality sputum culture or urine antigen positivity, our optimized case definition for PncCAP resulted in a trial sample size which was almost 20,000 subjects smaller. We believe that our novel application of LCA detailed here to determine a case definition for PncCAP could also be similarly applied to other diseases without a gold standard. © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.

  4. When do latent class models overstate accuracy for diagnostic and other classifiers in the absence of a gold standard?

    Science.gov (United States)

    Spencer, Bruce D

    2012-06-01

    Latent class models are increasingly used to assess the accuracy of medical diagnostic tests and other classifications when no gold standard is available and the true state is unknown. When the latent class is treated as the true class, the latent class models provide measures of components of accuracy including specificity and sensitivity and their complements, type I and type II error rates. The error rates according to the latent class model differ from the true error rates, however, and empirical comparisons with a gold standard suggest the true error rates often are larger. We investigate conditions under which the true type I and type II error rates are larger than those provided by the latent class models. Results from Uebersax (1988, Psychological Bulletin 104, 405-416) are extended to accommodate random effects and covariates affecting the responses. The results are important for interpreting the results of latent class analyses. An error decomposition is presented that incorporates an error component from invalidity of the latent class model. © 2011, The International Biometric Society.

  5. Reduced egfr, elevated urine protein and low level of personal protective equipment compliance among artisanal small scale gold miners at Bibiani-Ghana: a cross-sectional study.

    Science.gov (United States)

    Afrifa, Justice; Essien-Baidoo, Samuel; Ephraim, Richard K D; Nkrumah, Daniel; Dankyira, Daniel Osei

    2017-06-27

    Mercury is a toxic metal with its effects on human health ranging from acute to chronic in a very short time of exposure. Artisanal and small-scale gold mining (ASGM) is the main source of direct human exposure to mercury. To access the effect of mercury exposure on the renal function and level of personal protective equipment (PPE) compliance among small-scale gold miners in Bibiani District of the Western Region of Ghana METHOD: 110 consenting male gold miners were purposively recruited for this study. A structured questionnaire was used to collect socio-demographic information from the participants. Work place assessment and interviews were conducted. Urine samples were analysed for protein; blood was analysed for mercury and creatinine. Estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation. Of the 110 participants, 61(55.5%) exceeded the occupational exposure threshold (blood mercury <5μg/L). Urine protein (41.72±68.34, P<0.0001), serum creatinine (2.24±1.19, P<0.0001) and blood mercury (18.37±10.47, P<0.0001) were significantly elevated among the exposed group compared to the non-exposed group. However, the exposed group had a significantly reduced eGFR (P<0.0001). There was a significant correlation (r=0.7338, p<0.0001) between blood mercury concentration and urine protein concentration. An increase in blood mercury correlated negatively (r = -0.8233, P<0.0001) with eGFR among the exposed group. High urine protein (P< 0.0001) and high serum creatinine (P< 0.0001) were significantly associated with increased mercury exposure. Increased mercury exposure was significantly associated with burning of amalgam (P=0.0196), sucking of excess mercury (P=0.0336), longer work duration (P=0.0314) and low educational background (P=0.0473). Small scale miners at the Bibiani work site are exposed to excess mercury. Proteinuria and reduced eGFR is common in mine workers exposed to excess

  6. Cost Comparison of Fundamentals of Laparoscopic Surgery Training Completed With Standard Fundamentals of Laparoscopic Surgery Equipment versus Low-Cost Equipment.

    Science.gov (United States)

    Franklin, Brenton R; Placek, Sarah B; Wagner, Mercy D; Haviland, Sarah M; O'Donnell, Mary T; Ritter, E Matthew

    Training for the Fundamentals of Laparoscopic Surgery (FLS) skills test can be expensive. Previous work demonstrated that training on an ergonomically different, low-cost platform does not affect FLS skills test outcomes. This study compares the average training cost with standard FLS equipment and medical-grade consumables versus training on a lower cost platform with non-medical-grade consumables. Subjects were prospectively randomized to either the standard FLS training platform (n = 19) with medical-grade consumables (S-FLS), or the low-cost platform (n = 20) with training-grade products (LC-FLS). Both groups trained to proficiency using previously established mastery learning standards on the 5 FLS tasks. The fixed and consumable cost differences were compared. Training occurred in a surgical simulation center. Laparoscopic novice medical student and resident physician health care professionals who had not completed the national FLS proficiency curriculum and who had performed less than 10 laparoscopic cases. The fixed cost of the platform was considerably higher in the S-FLS group (S-FLS, $3360; LC-FLS, $879), and the average consumable training cost was significantly higher for the S-FLS group (S-FLS, $1384.52; LC-FLS, $153.79; p group had a statistically discernable cost reduction for each consumable (Gauze $9.24 vs. $0.39, p = 0.002; EndoLoop $540.00 vs. $40.60, p group versus $1647.95 in the LC-FLS group. This study shows that the average cost to train a single trainee to proficiency using a lower fixed-cost platform and non-medical-grade equipment results in significant financial savings. A 5-resident program will save approximately $8500 annually. Residency programs should consider adopting this strategy to reduce the cost of FLS training. Published by Elsevier Inc.

  7. Paralympic sports medicine--current evidence in winter sport: considerations in the development of equipment standards for paralympic athletes.

    Science.gov (United States)

    Burkett, Brendan

    2012-01-01

    To highlight and discuss the considerations for the future development of equipment standards for Winter Paralympic sports. Literature searches were performed (in English) during May 2011 using the key words "technology, winter sport, Olympic, and Paralympic" in the computerized databases PubMed, PsycINFO, Science Direct, and Google Scholar. In addition, personal scientific observations were made at several Winter Paralympic Games. The retrieved articles were screened and assessed for relevance to the biological, biomechanical, and sport medicine aspects of equipment. There are 3 key areas in which technology has influenced sports performance in Paralympic winter sports, namely, specialized prostheses, crutch skis or outriggers (in lieu of poles), and sport-specific wheelchairs (such as the sit-ski). From a sport medicine perspective, a crucial factor not considered in the standard laboratory test of mechanical efficiency is the influence of the human-equipment connection, such as the stump-to-prosthesis interface or the required human-to-wheelchair control. This connectivity is critical to the effective operation of the assistive device. When assessing the efficiency of this equipment, the not-so-obvious, holistic, compensatory factors need to be considered. Assistive equipment is fundamental for a person with a disability to participate and compete in winter sport activities. Although there have been improvements in the mechanical function of some assistive devices, the key issue is matching the residual function of the person with the assistive equipment. Equitable access to this technology will also ensure that the fundamental spirit of fair play that underpins the Paralympic Games is maintained.

  8. Gold monetization and gold discipline

    OpenAIRE

    Robert P. Flood; Peter M. Garber

    1981-01-01

    The paper is a study of the price level and relative price effects of a policy to monetize gold and fix its price at a given future time and at the then prevailing nominal price. Price movements are analyzed both during the transition to the gold standard and during the post-monetization period. The paper also explores the adjustments to fiat money which are necessary to ensure that this type of gold monetization is non-inflationary. Finally, some conditions which produce a run on the governm...

  9. 40 CFR Appendix B to Subpart B of... - Standard for Recover Equipment

    Science.gov (United States)

    2010-07-01

    ... protects the earth against harmful ultraviolet radiation. To reduce the emissions of CFCs, the 1990 Clean Air Act requires recycle of CFC-12 (R-12) used in mobile air-conditioning systems to eliminate system... reuse of CFCs in mobile air-conditioning systems. Establishing extraction equipment specifications for...

  10. 77 FR 58473 - Minimum Technical Standards for Class II Gaming Systems and Equipment

    Science.gov (United States)

    2012-09-21

    ... to all equipment, including computer, electronic, or other technologic aids used with Class II games..., computer, or other technologic aids in connection with the play of Class II games. This part establishes... gaming system, causes a discontinuance of game play or other component functions. Financial instrument...

  11. 77 FR 16769 - Energy Conservation Program for Certain Industrial Equipment: Energy Conservation Standards and...

    Science.gov (United States)

    2012-03-22

    ... provisions from AHRI operations manuals (OMs) in its test procedures that would clarify the application of... Compressor Break-In Period.... Small Unitary OM 3.8 (Break-in Certain AHRI OMs DOE is proposing to Operation... equipment class. Period). hours. Tolerances Multiple OMs.... N/A Certain AHRI OMs and Compliance with DOE...

  12. 77 FR 28927 - Energy Conservation Program for Certain Industrial Equipment: Energy Conservation Standards and...

    Science.gov (United States)

    2012-05-16

    ... provisions (with some modification) from AHRI operations manuals (AHRI OMs) that would harmonize equipment... DOE published for notice and comment. By adopting some of the guidance in the AHRI OMs, DOE hopes to... and DOE-initiated testing. In certain cases, the AHRI OMs require manufacturers to provide information...

  13. Detection of Echinococcus multilocularis by MC-PCR: evaluation of diagnostic sensitivity and specificity without gold standard

    Directory of Open Access Journals (Sweden)

    Helene Wahlström

    2016-03-01

    Full Text Available Introduction: A semi-automated magnetic capture probe-based DNA extraction and real-time PCR method (MC-PCR, allowing for a more efficient large-scale surveillance of Echinococcus multilocularis occurrence, has been developed. The test sensitivity has previously been evaluated using the sedimentation and counting technique (SCT as a gold standard. However, as the sensitivity of the SCT is not 1, test characteristics of the MC-PCR was also evaluated using latent class analysis, a methodology not requiring a gold standard. Materials and methods: Test results, MC-PCR and SCT, from a previous evaluation of the MC-PCR using 177 foxes shot in the spring (n=108 and autumn 2012 (n=69 in high prevalence areas in Switzerland were used. Latent class analysis was used to estimate the test characteristics of the MC-PCR. Although it is not the primary aim of this study, estimates of the test characteristics of the SCT were also obtained. Results and discussion: This study showed that the sensitivity of the MC-PCR was 0.88 [95% posterior credible interval (PCI 0.80–0.93], which was not significantly different than the SCT, 0.83 (95% PCI 0.76–0.88, which is currently considered as the gold standard. The specificity of both tests was high, 0.98 (95% PCI 0.94–0.99 for the MC-PCR and 0.99 (95% PCI 0.99–1 for the SCT. In a previous study, using fox scats from a low prevalence area, the specificity of the MC-PCR was higher, 0.999% (95% PCI 0.997–1. One reason for the lower estimate of the specificity in this study could be that the MC-PCR detects DNA from infected but non-infectious rodents eaten by foxes. When using MC-PCR in low prevalence areas or areas free from the parasite, a positive result in the MC-PCR should be regarded as a true positive. Conclusion: The sensitivity of the MC-PCR (0.88 was comparable to the sensitivity of SCT (0.83.

  14. 40 CFR Appendix E to Subpart B of... - The Standard for Automotive Refrigerant Recycling Equipment Intended for Use With Both CFC-12 and...

    Science.gov (United States)

    2010-07-01

    ... Refrigerant Recycling Equipment Intended for Use With Both CFC-12 and HFC-134a E Appendix E to Subpart B of... Appendix E to Subpart B of Part 82—The Standard for Automotive Refrigerant Recycling Equipment Intended for... Intended for Use With Both CFC-12 and HFC-134a Foreword The purpose of this standard is to establish...

  15. Equipment Sustainment Data in Standard Army Management Information Systems: Needs, Gaps, and Opportunities

    Science.gov (United States)

    2012-01-01

    DRMO Defense Reutilization and Marketing Service DS Direct Support ECR Equipment Control Record ERP Enterprise Resource Planning ESA Enterprise...and content. The Global Combat Support System-Army (GCSS-A) is an automated logistics system that uses the SAP Defense Forces and Public Security...DFPS) software platform to provide Enterprise Resource Planning ( ERP ). It is designed to integrate tactical logistics data and functions as related

  16. Web 2.0-based crowdsourcing for high-quality gold standard development in clinical natural language processing.

    Science.gov (United States)

    Zhai, Haijun; Lingren, Todd; Deleger, Louise; Li, Qi; Kaiser, Megan; Stoutenborough, Laura; Solti, Imre

    2013-04-02

    A high-quality gold standard is vital for supervised, machine learning-based, clinical natural language processing (NLP) systems. In clinical NLP projects, expert annotators traditionally create the gold standard. However, traditional annotation is expensive and time-consuming. To reduce the cost of annotation, general NLP projects have turned to crowdsourcing based on Web 2.0 technology, which involves submitting smaller subtasks to a coordinated marketplace of workers on the Internet. Many studies have been conducted in the area of crowdsourcing, but only a few have focused on tasks in the general NLP field and only a handful in the biomedical domain, usually based upon very small pilot sample sizes. In addition, the quality of the crowdsourced biomedical NLP corpora were never exceptional when compared to traditionally-developed gold standards. The previously reported results on medical named entity annotation task showed a 0.68 F-measure based agreement between crowdsourced and traditionally-developed corpora. Building upon previous work from the general crowdsourcing research, this study investigated the usability of crowdsourcing in the clinical NLP domain with special emphasis on achieving high agreement between crowdsourced and traditionally-developed corpora. To build the gold standard for evaluating the crowdsourcing workers' performance, 1042 clinical trial announcements (CTAs) from the ClinicalTrials.gov website were randomly selected and double annotated for medication names, medication types, and linked attributes. For the experiments, we used CrowdFlower, an Amazon Mechanical Turk-based crowdsourcing platform. We calculated sensitivity, precision, and F-measure to evaluate the quality of the crowd's work and tested the statistical significance (Pcrowdsourced and traditionally-developed annotations. The agreement between the crowd's annotations and the traditionally-generated corpora was high for: (1) annotations (0.87, F-measure for medication names

  17. Reconsidering the H&E stain as the gold standard in assessing the depth of burn wounds.

    Science.gov (United States)

    Rosenberg, Arlene S

    2017-12-01

    While histological examination is considered by most as the gold standard for burn depth assessment, it has no practical use in the clinical setting. It has, however, been used in the research setting, as a mean for evaluating emerging techniques of depth measurement. Due to the limitations of the H&E stain, other stains have also been explored, such as lactate dehydrogenase (LDH), as presented in this issue, in "Improving the Histologic Characterization of Burn Depth." As the determination of burn depth is not a typical subject in dermatopathology, a summary of selected techniques and the possible role for the LDH stain in future research, is described herein. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Utilising magnetic resonance imaging as the gold-standard in management of suspected scaphoid fractures in the emergency department setting

    LENUS (Irish Health Repository)

    Ramasubbu, B

    2017-02-01

    Scaphoid fractures are the most common carpal bone fracture. Up to 40% of scaphoid fractures can be missed at initial presentation and investigation. Follow-up plain film radiograph has overall poor sensitivity and reliability. MRI has been shown to have an almost 100% sensitivity and specificity and so is the gold standard in scaphoid fracture diagnosis. Additionally, early specialist involvement is recommended. We proposed that following a designated pathway, there would be no significant increase in MRI requests. Following implementation of a pathway for the management of suspected scaphoid fractures in St James’s Hospital in 2012 re-auditing demonstrated that management changed to either MRI directly after initial x-ray (16\\/145, 11%), MRI after second x-ray (9\\/28, 32%) or orthopaedic follow-up (19\\/28, 68%). The number of MRIs requested was consistent with our predictors of demand. Thus, our new protocol maximises diagnostics, cost effectiveness and quality of patient care.

  19. Biometry and intraocular lens power calculation results with a new optical biometry device: comparison with the gold standard.

    Science.gov (United States)

    Kaswin, Godefroy; Rousseau, Antoine; Mgarrech, Mohamed; Barreau, Emmanuel; Labetoulle, Marc

    2014-04-01

    To evaluate the agreement in axial length (AL), keratometry (K), anterior chamber depth (ACD) measurements; intraocular lens (IOL) power calculations; and predictability using a new partial coherence interferometry (PCI) optical biometer (AL-Scan) and a reference (gold standard) PCI optical biometer (IOLMaster 500). Service d'Ophtalmologie, Hopital Bicêtre, APHP Université, Paris, France. Evaluation of a diagnostic device. One eye of consecutive patients scheduled for cataract surgery was measured. Biometry was performed with the new biometer and the reference biometer. Comparisons were performed for AL, average K at 2.4 mm, ACD, IOL power calculations with the Haigis and SRK/T formulas, and postoperative predictability of the devices. A P value less than 0.05 was statistically significant. The study enrolled 50 patients (mean age 72.6 years±4.2 SEM). There was a good correlation between biometers for AL, K, and ACD measurements (r=0.999, r=0.933, and r=0.701, respectively) and between IOL power calculation with the Haigis formula (r=0.972) and the SRK/T formula (r=0.981). The mean absolute error (MAE) in IOL power prediction was 0.42±0.08 diopter (D) with the new biometer and 0.44±0.08 D with the reference biometer. The MAE was 0.20 D with the Haigis formula and 0.19 with the SRK/T formula (P=.36). The new PCI biometer provided valid measurements compared with the current gold standard, indicating that the new device can be used for IOL power calculations for routine cataract surgery. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  20. 78 FR 55889 - Energy Conservation Program: Energy Conservation Standards for Commercial Refrigeration Equipment

    Science.gov (United States)

    2013-09-11

    ... in ANSI/Air- Conditioning and Refrigeration Institute (ARI) Standard 1200-2006, appendix D. [dagger... Manufacturers C. National Benefits II. Introduction A. Authority B. Background 1. Current Standards 2. History... class terminology. ** ``TDA'' is the total display area of the case, as measured in the Air...

  1. 78 FR 4873 - Electrical Protective Equipment Standard and the Electric Power Generation, Transmission, and...

    Science.gov (United States)

    2013-01-23

    ... performing job duties. The training requirements of the Standard inform workers of the safety hazards of... this method, you must submit a copy of your comments and attachments to the OSHA Docket Office, Docket... Distribution Standard (Sec. 1910.269) Training Certification (Sec. 1910.269(a)(2)(vii)) This provision requires...

  2. Compliance to Standard Equipment Requirements by Exercise Therapy/Fitness Outfits in The South-South Geopolitical Zone of Nigeria

    Directory of Open Access Journals (Sweden)

    Oluwaseun S. Kubeyinje

    2016-08-01

    Full Text Available The purpose of this study was to assess the compliance of exercise therapy/fitness outfits in the south-south geopolitical zone of Nigeria to standard equipment requirements. Descriptive survey design was adopted for the conduct of the study using a sample size of 51centres/managers purposively selected from a population of 102 managers of fitness outfits in the six states of the south-south geopolitical zone of Nigeria. A self- developed structured questionnaire and a facility checklist were used to collect the data. Data collected were analysed using frequency counts and percentages. The study revealed in this analysis that only treadmills (66.7%, bicycle ergometers (66.7%, dumbbells (84.3% and weight racks (57.0% met the benchmark minimum in more than 50% of the exercise therapy/fitness outfits surveyed in six states of the south-south geopolitical zone of Nigeria. Most of the equipment surveyed were functional with the highest non-functionality occurring in treadmill machines in 9.8% of the surveyed centres followed by sit-up benches (5.9% and bicycle ergometers (3.9%. In conclusion, it could be deduced from the results that there’s gross inadequacy of equipment and low level of compliance to established standard in the exercise therapy/fitness outfits evaluated in the south-south geopolitical zone of Nigeria.

  3. 77 FR 72851 - California State Nonroad Engine Pollution Control Standards; Portable Equipment Registration...

    Science.gov (United States)

    2012-12-06

    ... evidence that passes the threshold test of materiality and * * * thereafter assess such material evidence... standards, the overall cost to those parties would be around $250 million.\\44\\ The PERP thus results in an...

  4. Sterilization of allograft bone: is 25 kGy the gold standard for gamma irradiation?

    Science.gov (United States)

    Nguyen, Huynh; Morgan, David A F; Forwood, Mark R

    2007-01-01

    For several decades, a dose of 25 kGy of gamma irradiation has been recommended for terminal sterilization of medical products, including bone allografts. Practically, the application of a given gamma dose varies from tissue bank to tissue bank. While many banks use 25 kGy, some have adopted a higher dose, while some choose lower doses, and others do not use irradiation for terminal sterilization. A revolution in quality control in the tissue banking industry has occurred in line with development of quality assurance standards. These have resulted in significant reductions in the risk of contamination by microorganisms of final graft products. In light of these developments, there is sufficient rationale to re-establish a new standard dose, sufficient enough to sterilize allograft bone, while minimizing the adverse effects of gamma radiation on tissue properties. Using valid modifications, several authors have applied ISO standards to establish a radiation dose for bone allografts that is specific to systems employed in bone banking. These standards, and their verification, suggest that the actual dose could be significantly reduced from 25 kGy, while maintaining a valid sterility assurance level (SAL) of 10(-6). The current paper reviews the methods that have been used to develop radiation doses for terminal sterilization of medical products, and the current trend for selection of a specific dose for tissue banks.

  5. Control protocol: the proposed new CERN standard access procedure to accelerator equipment

    International Nuclear Information System (INIS)

    Baribaud, G.; Barnett, I.; Benincasa, G.

    1992-01-01

    Control protocol provides a normalized access procedure for equipment of the same kind from a control system. Modelisation and the subsequent identification of functionalities with their parameters, variables and attributes have now been carried out at CERN for representative families of devices. ISO specifications, such as the ASN.1 metalanguage for data structure representation and MMS definitions and services have, to some extent, been introduced in the design for generality and compatibility with external world. The final product of this design is totally independent of the control systems and permits object oriented implementations in any controls frame. The present paper describes the different phases of the project with a short overview of the various implementations under development at CERN. (author)

  6. Continuous ECG Monitoring in Patients With Acute Coronary Syndrome or Heart Failure: EASI Versus Gold Standard.

    Science.gov (United States)

    Lancia, Loreto; Toccaceli, Andrea; Petrucci, Cristina; Romano, Silvio; Penco, Maria

    2018-05-01

    The purpose of the study was to compare the EASI system with the standard 12-lead surface electrocardiogram (ECG) for the accuracy in detecting the main electrocardiographic parameters (J point, PR, QT, and QRS) commonly monitored in patients with acute coronary syndromes or heart failure. In this observational comparative study, 253 patients who were consecutively admitted to the coronary care unit with acute coronary syndrome or heart failure were evaluated. In all patients, two complete 12-lead ECGs were acquired simultaneously. A total of 6,072 electrocardiographic leads were compared (3,036 standard and 3,036 EASI). No significant differences were found between the investigate parameters of the two measurement methods, either in patients with acute coronary syndrome or in those with heart failure. This study confirmed the accuracy of the EASI system in monitoring the main ECG parameters in patients admitted to the coronary care unit with acute coronary syndrome or heart failure.

  7. Realism and Imagination in Child Foreign-Language Productions: Three Reasons for an Early Exit from the "Gold Standard" of Personal Experience

    Science.gov (United States)

    Hong, Seongeun; Kellogg, David

    2016-01-01

    Teachers often assume that personal experience is a rich resource for classroom chat and a gold standard for meaningful exchange of information. But in this paper, we first present three kinds of reasons for suspecting that primary intersubjectivity--the "me and you" relationship in which personal experiences are directly exchanged…

  8. VALIDATION OF MITRAL VALVE ANNULUS DIMENSIONS MEASURED BY 2D TRANS-THORACIC ECHOCARDIOGRAPHY WITH GOLD STANDARD DIRECT INTRA-OPERATIVE MEASUREMENT

    OpenAIRE

    Praveen; Yadav; Ankur; Saket; Kaushal

    2014-01-01

    CONTEXT: Precise estimation of Mitral valve annulus dimensions preoperatively through Echocardiography is of paramount importance in replacement/repair surgeries. However a frequent disagreement was experienced between anticipated size of prosthetic valve based on echocardiography and actual valve size. This fact encouraged the authors to validate the measurements through echocardiography with gold-standard direct intra operative measurement. AIM: To compare the mitral val...

  9. Sleep apnea detection by a cardiac resynchronization device integrated thoracic impedance sensor: A validation study against the gold standard polysomnography.

    Science.gov (United States)

    Barbieri, Fabian; Dichtl, Wolfgang; Heidbreder, Anna; Brandauer, Elisabeth; Stefani, Ambra; Adukauskaite, Agne; Senoner, Thomas; Schgör, Wilfried; Hintringer, Florian; Högl, Birgit

    2018-01-01

    Sleep disordered breathing is a common but often undiagnosed comorbidity in heart failure patients. Cardiac implantable electronic devices used for cardiac resynchronization therapy (CRT) may detect sleep apnea by use of a transthoracic impedance sensor. Validation of the AP scan® algorithm (Boston Scientific®) was performed by using the diagnostic gold standard polysomnography (PSG). Forty-one patients with impaired left ventricular ejection fraction, frequent right ventricular pacing due to atrioventricular block and heart failure symptoms despite optimal medical therapy underwent upgrading to biventricular pacing. Within one month after left ventricular lead implantation, sleep apnea was assessed by single-night PSG and AP scan® measurements. AP scan® measurements were valid in only 21 of 41 (51.2%) patients in the index night of the PSG. The PSG determined apnea-hypopnea index did not correlate statistically significant with the AP scan® measurements (r = 0.41, 95% confidence interval -0.05-0.72, p = 0.07). The degree of overestimation is displayed by using the Bland-Altman method: mean difference -12.4, standard deviation ± 15.8, 95% confidence interval -43.3-18.6. In heart failure patients receiving CRT upgrading, the AP scan® algorithm may need further improvement before it can be recommended for sleep apnea detection.

  10. 77 FR 40843 - Federal Motor Vehicle Safety Standard No. 108; Lamp, Reflective Devices, and Associated Equipment

    Science.gov (United States)

    2012-07-11

    ... limiting the impacts of glare. Our current standard primarily treats a headlamp as a separate piece of...) at any time by going to http://www.regulations.gov . Follow the online instructions for accessing the dockets. You may also read the materials at the Docket Management Facility by going to the street address...

  11. 75 FR 21567 - Federal Motor Vehicle Safety Standard No. 108; Lamp, Reflective Devices and Associated Equipment...

    Science.gov (United States)

    2010-04-26

    ... the motorcycle headlighting system location requirements for a single headlamp with multiple light sources. The current standard requires that the light sources contained in a single motorcycle headlamp containing multiple light sources be located on the vertical centerline of the vehicle or horizontally...

  12. 76 FR 43941 - Energy Conservation Program: Energy Conservation Standards for Direct Heating Equipment

    Science.gov (United States)

    2011-07-22

    ... included the HPBA membership directory, Air-Conditioning, Heating, and Refrigeration Institute (AHRI.... Summary of the Proposed Rule II. History of the Energy Conservation Standards Rulemaking and Current... notice. DOE's rationale is presented in further detail immediately below. II. History of the Energy...

  13. 77 FR 70390 - Lifesaving Equipment: Production Testing and Harmonization With International Standards

    Science.gov (United States)

    2012-11-26

    ... components within the system to be made of corrosion-resistant materials without the need for galvanizing... resistant in the marine environment without the need for coatings or galvanizing,'' the current ASTM.... This standard would no longer be appropriate because these steels require coatings or galvanizing to be...

  14. 76 FR 41181 - Federal Motor Vehicle Safety Standards; Lamps, Reflective Devices, and Associated Equipment

    Science.gov (United States)

    2011-07-13

    ... to restore the blue and green color boundaries to Federal Motor Vehicle Safety Standard (FMVSS) No... number in the heading of this document, by any of the following methods: Federal eRulemaking Portal: Go... comment, if submitted on behalf of an association, business, labor union, etc.). You may review DOT's...

  15. 76 FR 23255 - Federal Motor Vehicle Safety Standards; Lamps, Reflective Devices, and Associated Equipment

    Science.gov (United States)

    2011-04-26

    ... petitions for reconsideration from Harley-Davidson Motor Company (January 18, 2008) and Ford Motor Company... [Docket No. NHTSA-2007-28322] Federal Motor Vehicle Safety Standards; Lamps, Reflective Devices, and... part, the petitions for reconsideration of the December 4, 2007, final rule reorganizing Federal Motor...

  16. 77 FR 2355 - Energy Conservation Program for Certain Industrial Equipment: Energy Conservation Standards and...

    Science.gov (United States)

    2012-01-17

    ... advantages; distributive impacts; and equity); (4) to the extent feasible, specify performance objectives... Defense Council (NRDC), the Northwest Energy Efficiency Alliance (NEEA), and the Northwest Power and... Strategic Plan commits the Department to reviewing minimum appliance efficiency standards at least every 5...

  17. 76 FR 25622 - Energy Conservation Program for Certain Industrial Equipment: Energy Conservation Standards for...

    Science.gov (United States)

    2011-05-05

    ... also requires that each time the corresponding consensus standard--the American Society of Heating... this analysis, as well as the submission of data and other relevant information. DATES: DOE will accept... Information Number (RIN) 1904-AC47. Comments may be submitted using any of the following methods: 1. Federal e...

  18. Airside HVAC BESTEST. Adaptation of ASHRAE RP 865 Airside HVAC Equipment Modeling Test Cases for ASHRAE Standard 140. Volume 1, Cases AE101-AE445

    Energy Technology Data Exchange (ETDEWEB)

    Neymark, J. [J. Neymark & Associates, Golden, CO (United States); Kennedy, M. [Mike D. Kennedy, Inc., Townsend, WA (United States); Judkoff, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gall, J. [AAON, Inc., Tulsa, OK (United States); Knebel, D. [AAON, Inc., Tulsa, OK (United States); Henninger, R. [GARD Analytics, Inc., Arlington Heights, IL (United States); Witte, M. [GARD Analytics, Inc., Arlington Heights, IL (United States); Hong, T. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); McDowell, T. [Thermal Energy System Specialists, Madison, WI (United States); Yan, D. [Tsinghua Univ., Beijing (China); Zhou, X. [Tsinghua Univ., Beijing (China)

    2016-03-01

    This report documents a set of diagnostic analytical verification cases for testing the ability of whole building simulation software to model the air distribution side of typical heating, ventilating and air conditioning (HVAC) equipment. These cases complement the unitary equipment cases included in American National Standards Institute (ANSI)/American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE) Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs, which test the ability to model the heat-transfer fluid side of HVAC equipment.

  19. Standard Measurement & Verification Plan for Lighting Equipment Retrofit or Replacement Projects

    Energy Technology Data Exchange (ETDEWEB)

    Richman, Eric E.

    2009-11-04

    This document provides a framework for a standard Measurement and Verification (M&V) plan for lighting projects. It was developed to support cost-effective retrofits (partial and complete replacements) of lighting systems and is intended to provide a foundation for an M&V plan for a lighting retrofit utilizing a "best practice" approach, and to provide guidance to site owners, contractors, and other involved organizations on what is essential for a robust M&V plan for lighting projects. This document provides examples of appropriate elements of an M&V plan, including the calculation of expected energy savings. The standard M&V plan, as provided, also allows for consistent comparison with other similar lighting projects. Although intended for lighting retrofit applications, M&V plans developed per this framework document may also be used for other non-lighting technology retrofits and new installations.

  20. The Effects of Property, Plant and Equipment (TAS 16 Standard on Cost of Sales of Manufacturing Companies

    Directory of Open Access Journals (Sweden)

    İlker KIYMETLİ ŞEN

    2013-06-01

    Full Text Available According to the Turkish Commercial Code that came into force in July 2012, the all capital companies that meet the criteria described by the Council of Ministers are required to be in compliance with accounting and financial reporting standards published by the Public Oversight, Accounting and Auditing Board. There are several differences between the local accounting regulations and the standards in terms of valuation, computation and presentation. These differences also affect the cost of sales of the companies that result in differences in the calculation of costs of goods manufactured. The purpose of this study is to examine and demonstrate the potential effects of the TAS 16 Property, Plant and Equipment on calculations of manufacturing costs and the cost of sales of manufacturing companies.

  1. A gold standard method for the evaluation of antibody-based materials functionality: Approach to forced degradation studies.

    Science.gov (United States)

    Coussot, Gaëlle; Le Postollec, Aurélie; Faye, Clément; Dobrijevic, Michel

    2018-04-15

    The scope of this paper is to present a gold standard method to evaluate functional activity of antibody (Ab)-based materials during the different phases of their development, after their exposure to forced degradations or even during routine quality control. Ab-based materials play a central role in the development of diagnostic devices, for example, for screening or therapeutic target characterization, in formulation development, and in novel micro(nano)technology approaches to develop immunosensors useful for the analysis of trace substances in pharmaceutical and food industries, clinical and environmental fields. A very important aspect in diagnostic device development is the construction of its biofunctional surfaces. These Ab surfaces require biocompatibility, homogeneity, stability, specificity and functionality. Thus, this work describes the validation and applications of a unique ligand binding assay to directly perform the quantitative measurement of functional Ab binding sites immobilized on the solid surfaces. The method called Antibody Anti-HorseRadish Peroxidase (A2HRP) method, uses a covalently coated anti-HRP antibody (anti-HRP Ab) and does not need for a secondary Ab during the detection step. The A2HRP method was validated and gave reliable results over a wide range of absorbance values. Analyzed validation criteria were fulfilled as requested by the food and drug administration (FDA) and European Medicines Agency (EMA) guidance for the validation of bioanalytical methods with 1) an accuracy mean value within +15% of the nominal value; 2) the within-assay precision less than 7.1%, and 3) the inter-day variability under 12.1%. With the A2HRP method, it is then possible to quantify from 0.04 × 10 12 to 2.98 × 10 12 functional Ab binding sites immobilized on the solid surfaces. A2HRP method was validated according to FDA and EMA guidance, allowing the creation of a gold standard method to evaluate Ab surfaces for their resistance under

  2. Terms standardization between the rules of diagnosis radiation equipment safety management and atomic energy law: problems and suggestions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hwa Gon; Kang, Se Sik; Kim, Chang Soo; Park, Cheol Seo [Catholic University of Pusan, Busan (Korea, Republic of)

    2006-03-15

    The rules and terms are described different meaning in this results the research is accomplished for preventing practical workers from confusion. Atomic law are kept up modification and development in our situation by the ICRP's recommendation, on the other hand, the rules of diagnosis radiation equipment safety managements are modified partial, then resulted in confusion. The study was comparison between the rules of diagnosis radiation equipment safety management and atomic energy law, and the modification items obtained were as follows. With each other different the terms and units are used. With the exception of special terms for affairs usage, it is needless to say that common term uniformity is standardized. The standardization of rules and guidance have not need to confusion radiological practical workers. The following is omitted. The radiation protection against the patient and the hospital visitor. Radiation dose limit of the woman patient who is in the process of becoming pregnant. Radiation dose limit of the person who is not regarded as medical exposure. The control of the exposure of pregnant of women at work.

  3. Terms standardization between the rules of diagnosis radiation equipment safety management and atomic energy law: problems and suggestions

    International Nuclear Information System (INIS)

    Kim, Hwa Gon; Kang, Se Sik; Kim, Chang Soo; Park, Cheol Seo

    2006-01-01

    The rules and terms are described different meaning in this results the research is accomplished for preventing practical workers from confusion. Atomic law are kept up modification and development in our situation by the ICRP's recommendation, on the other hand, the rules of diagnosis radiation equipment safety managements are modified partial, then resulted in confusion. The study was comparison between the rules of diagnosis radiation equipment safety management and atomic energy law, and the modification items obtained were as follows. With each other different the terms and units are used. With the exception of special terms for affairs usage, it is needless to say that common term uniformity is standardized. The standardization of rules and guidance have not need to confusion radiological practical workers. The following is omitted. The radiation protection against the patient and the hospital visitor. Radiation dose limit of the woman patient who is in the process of becoming pregnant. Radiation dose limit of the person who is not regarded as medical exposure. The control of the exposure of pregnant of women at work

  4. CRM Assessment: Determining the Generalization of Rater Calibration Training. Summary of Research Report: Gold Standards Training

    Science.gov (United States)

    Baker, David P.

    2002-01-01

    The extent to which pilot instructors are trained to assess crew resource management (CRM) skills accurately during Line-Oriented Flight Training (LOFT) and Line Operational Evaluation (LOE) scenarios is critical. Pilot instructors must make accurate performance ratings to ensure that proper feedback is provided to flight crews and appropriate decisions are made regarding certification to fly the line. Furthermore, the Federal Aviation Administration's (FAA) Advanced Qualification Program (AQP) requires that instructors be trained explicitly to evaluate both technical and CRM performance (i.e., rater training) and also requires that proficiency and standardization of instructors be verified periodically. To address the critical need for effective pilot instructor training, the American Institutes for Research (AIR) reviewed the relevant research on rater training and, based on "best practices" from this research, developed a new strategy for training pilot instructors to assess crew performance. In addition, we explored new statistical techniques for assessing the effectiveness of pilot instructor training. The results of our research are briefly summarized below. This summary is followed by abstracts of articles and book chapters published under this grant.

  5. Ammunition Peculiar Equipment (APE) 1995, NIR Propellant Analyzer, to MIL-STD-398, Military Standard Shields, Operational for Ammunition Operations, Criteria for Design of and Tests for Acceptance

    National Research Council Canada - National Science Library

    2003-01-01

    ... (SJMAC-DEM) to test the Ammunition Peculiar Equipment (APE) 1995 NIR Propellant Analyzer, to MIL-STD-398, "Military Standard Shields, Operational for Ammunition Operations, Criteria for Design of and Tests for Acceptance...

  6. 40 CFR 1068.425 - What happens if one of my production-line engines/equipment exceeds the emission standards?

    Science.gov (United States)

    2010-07-01

    ... FOR ENGINE PROGRAMS Selective Enforcement Auditing § 1068.425 What happens if one of my production... engine/equipment to show it complies with all emission standards. (2) Include in your written report a...

  7. Multidetector CT: a new gold standard in the diagnosis of pulmonary embolism? State of the art and diagnostic algorithms

    International Nuclear Information System (INIS)

    Russo, Vincenzo; Piva, Tommaso; Lovato, Luigi; Fattori, Rossella; Gavelli, Giampaolo

    2005-01-01

    Purpose: From the early 90s, spiral CT technology has considerably changed the diagnostic capability of Pulmonary Embolism (PE), giving a direct vision of intravascular thrombi. Further technological progress has straightened its diagnostic impact leading to an essential role in clinical practice. The advent of Multi-Detector CT (MDCT) has subsequently increased the reliability of this technique to the point of undermining the role of pulmonary angiography as the gold standard and occupying a central position in diagnostic algorithms. The aim of this paper is to appraise this evolution by means of a meta-analysis of the relevant literature from 1995 to 2004. Results: The review of the literature showed the sensitivity and specificity of CT to have increased from 37-94% and 91-100% (single detector CT) to 87-94% and 94-100% (4-channel multidetector CT), especially thanks to the possibility of depicting subsegmental clots, with an interobserver agreement of 0.63-0.94 (k). Conclusions: CT is one of the most reliable and effective methods in the diagnosis is PE, with the advantage of being extremely fast and providing alternative diagnoses. Recent improvements in MDCT technology confers the highest value of diagnostic accuracy with respect to other imaging modalities such as scintigraphy, angiography, MRI, D-dimer essay and Doppler US [it

  8. The quality of operative note taking: an audit using the Royal College of Surgeons Guidelines as the gold standard.

    Science.gov (United States)

    Shayah, A; Agada, F O; Gunasekaran, S; Jassar, P; England, R J A

    2007-04-01

    To assess the quality of operative note keeping and compare the results with the Royal College of Surgeons (RCS) of England guidelines 'Good Surgical Practice' as the gold standard. ENT Department at Hull Royal Infirmary, University Hospital. A hundred consecutive operative notes were selected between November 2005 and January 2006. The documentation of the operative notes in each case was compared with the RCS of England guidelines. All surgeons were made aware of the results of the first cycle and the guidelines were made available in all ENT theatres in the form of a printed aide-memoir. A second audit cycle was then carried out prospectively between April and June 2006. The results demonstrated a change in practice in key areas. The 1st cycle results showed the documentation of patient identification (94%), name of surgeon (98%) and clearly written postoperative instructions (94%). However, surgeons performed suboptimally at recording the name of assistant (82%), operative diagnosis (46%), the incision type (87%) and the type of wound closure (83%). After introducing the aide-memoir, the second cycle demonstrated a change in practice with 100% documentation in most of the assessed parameters except that the time of surgery and the type of surgery (emergency or elective) were not adequately recorded. We recommend that all surgical departments should have the RCS guidelines as an aide-memoir in theatres to enhance the quality and standardise operative note recording.

  9. Histopathological examination of nail clippings using PAS staining (HPE-PAS): gold standard in diagnosis of Onychomycosis.

    Science.gov (United States)

    Jeelani, Shazia; Ahmed, Qazi Masood; Lanker, Audil Mohmad; Hassan, Iffat; Jeelani, Nasir; Fazili, Tawheeda

    2015-01-01

    Onychomycosis is fungal infection of one or more of the nail units. However, because fungi cause only about half of all nail dystrophies, the use of appropriate diagnostic techniques is important to ensure correct diagnosis and treatment. Aim of the present study was to compare direct microscopy, culture and HPE-PAS for diagnosis of onychomycosis by evaluating their sensitivity and various other relevant statistical parameters. A prospective, hospital-based, cross-sectional study was conducted on 216 patients with a high degree of clinical suspicion of onychomycosis. Nail specimens were evaluated using three diagnostic methods, i.e. direct microscopy using 20% Potassium hydroxide (KOH) & 40% Di-methyl-suphoxide (DMSO), culture and histopathological examination using PAS stain (HPE-PAS). Of 216 patients direct microscopy was positive in 138 (63.9%), culture in 147 (68%) and HPE-PAS in 164 patients (76%). One hundred and seventy-nine patients fitted into the criteria set for confirmed diagnosis of onychomycosis. Using this as a denominator; direct microscopy, culture and HPE-PAS had sensitivities of 77.1%, 70% and 91.6% respectively. Also, HPE-PAS showed the highest sensitivity of 94.7% in 19 cases with prediagnostic antimycotic treatment compared to direct microscopy (42.1%) or culture (57.9%). HPE-PAS shows high sensitivity for diagnosis of onychomycosis and can be considered as a gold standard in the diagnosis of onychomycosis. © 2014 Blackwell Verlag GmbH.

  10. Setting up processes and standardization of the equipment in order to optimize analyses of the wavelength dispersion X-ray fluorescence (WDXRF) system

    International Nuclear Information System (INIS)

    Phan Trong Phuc; Luu Anh Tuyen; La Ly Nguyen; Nguyen Thi Ngoc Hue; Pham Thi Hue; Do Duy Khiem

    2015-01-01

    For the purpose of operating and optimizing the analyses of the equipment: wavelength dispersion X-ray fluorescence (WDXRF)- model S8 TIGER from Enhancing Equipment Project (TCTTB) 2011-2012, we set up sampling and analytical process for different sample kinds; we constructed multi-elemental calibration curve for clay sample; we analysed elemental concentrations of 5 clay samples by XRF method and compared the results with the results given by NAA method. Equipment sensitivity was tested by analysing elemental concentrations of 2 Kaolin standard samples. The results show that S8-Tiger equipment is within good condition and is able to analyze powder clay sample exactly. (author)

  11. Spectrophotometric Evaluation of Polyetheretherketone (PEEK as a Core Material and a Comparison with Gold Standard Core Materials

    Directory of Open Access Journals (Sweden)

    Bogna Stawarczyk

    2016-06-01

    Full Text Available This study investigated the colorimetric properties of different veneering materials on core materials. Standardized specimens (10 mm × 10 mm × 1.5 mm reflecting four core (polyetheretherketone (PEEK, zirconia (ZrO2, cobalt–chromium–molybdenum alloy (CoCrMo, and titanium oxide (TiO2; thickness: 1.5 mm and veneering materials (VITA Mark II, IPS e.max CAD, LAVA Ultimate and VITA Enamic, all in shade A3; thickness: 0.5, 1.0, 1.5 and 2 mm, respectively were fabricated. Specimens were superimposed to assemblies, and the color was determined with a spectrophotometer (CieLab-System or a chair-side color measurement device (VITA EasyShade, respectively. Data were analyzed using three-, two-, and one-way ANOVA, a Chi2-test, and a Wilson approach (p < 0.05. The measurements with EasyShade showed A2 for VITA Mark II, A3.5 for VITA Enamic, B2 for LAVA Ultimate, and B3 for IPS e.max CAD. LabE-values showed significant differences between the tested veneering materials (p < 0.001. CieLab-System and VITA EasyShade parameters of the different assemblies showed a significant impact of core (p < 0.001, veneering material (p < 0.001, and thickness of the veneering material (p < 0.001. PEEK as core material showed comparable outcomes as compared to ZrO2 and CoCrMo, with respect to CieLab-System parameters for each veneering material. The relative frequency of the measured VITA EasyShade parameters regarding PEEK cores also showed comparable results as compared to the gold standard CoCrMo, regardless of the veneering material used.

  12. Biomonitoring of trace-element air pollution in a gold mining area in Ghana using the generalized k0-standardization NAA method

    International Nuclear Information System (INIS)

    Nyarko, B.J.B.; Kyere, A.W.K.; Serfor-Armah, Y.; Akaho, E.H.K.

    2003-01-01

    Full text: Mining activities contribute immensely to trace element atmospheric pollution. In Ghana, air pollution due to gold mining is the least investigated. In order to obtain preliminary information on air quality in the mining areas, the generalized k o- Standardization neutron activation analysis (NAA) method for nuclides following '1/v' and non-'1/v' (n,γ) reactions was used to analyse lichen samples from Prestea, a gold mining area in Ghana. Using the computed EPI values of both the Hogdahl-convention and the modified Westcott-formalism with gold as comparator standard, the IAEA lichen 336 certified reference material (CRM) and the lichen samples were irradiated in the inner irradiation site of the Ghana Research Reactor-1 (GHARR-1) operating at a thermal neutron flux of 5.0x10 11 ns -1 cm -2 . Comparison of the results with samples obtained from a non-mining (control) area, indicates that values of some metal pollutants such as As, Cr, Sb, and V were found to be higher in the lichens from the mining area than those in the non-mining area (control area); signifying accumulation of these metal pollutant due to gold - mining activities. (author)

  13. Multidetector CT: a new gold standard in the diagnosis of pulmonary embolism? State of the art and diagnostic algorithms; La TC multitettore: il nuovo gold standard nella diagnosi di embolia polmonare? Stato dell'arte e algoritmi diagnostici

    Energy Technology Data Exchange (ETDEWEB)

    Russo, Vincenzo; Piva, Tommaso; Lovato, Luigi; Fattori, Rossella; Gavelli, Giampaolo [Policlinico S. Orsola, Bologna (Italy). Dipartimento di Radiologia Radiologia III

    2005-02-01

    Purpose: From the early 90s, spiral CT technology has considerably changed the diagnostic capability of Pulmonary Embolism (PE), giving a direct vision of intravascular thrombi. Further technological progress has straightened its diagnostic impact leading to an essential role in clinical practice. The advent of Multi-Detector CT (MDCT) has subsequently increased the reliability of this technique to the point of undermining the role of pulmonary angiography as the gold standard and occupying a central position in diagnostic algorithms. The aim of this paper is to appraise this evolution by means of a meta-analysis of the relevant literature from 1995 to 2004. Results: The review of the literature showed the sensitivity and specificity of CT to have increased from 37-94% and 91-100% (single detector CT) to 87-94% and 94-100% (4-channel multidetector CT), especially thanks to the possibility of depicting subsegmental clots, with an interobserver agreement of 0.63-0.94 (k). Conclusions: CT is one of the most reliable and effective methods in the diagnosis is PE, with the advantage of being extremely fast and providing alternative diagnoses. Recent improvements in MDCT technology confers the highest value of diagnostic accuracy with respect to other imaging modalities such as scintigraphy, angiography, MRI, D-dimer essay and Doppler US. [Italian] Scopo: Dall'inizio degli anni '90, la tecnologia TC spirale (TCS) ha cambiato notevolmente la capacita' diagnostica di Embolia Polmonare (EP), fornendo una visione diretta dei trombi endoluminali. Successivi progressi tecnologici hanno fortificato il suo impatto diagnostico a tal punto che questa metodica e' ora essenziale nella pratica clinica. L'avvento della TC Multi-Detettore (TCMD) ha aumentato di conseguenza l'affidabilita' di questa tecnica fino a tal punto da scalzare l'angiopneumografia dal ruolo di Gold Standard ed occupare una posizione cantrale negli algoritmi diagnostici

  14. Outpatient laparoscopic cholecystectomy: A new gold standard for cholecystectomy? Colecistectomía laparoscópica ambulatoria: ¿El nuevo "gold standard" de la colecistectomía?

    Directory of Open Access Journals (Sweden)

    J. Bueno Lledó

    2006-01-01

    Full Text Available Objective: to contribute our experience for five years in the implemetation of outpatient laparoscopic cholecystectomy (LC. Patients: between January 1999 and March 2004 we performed 504 outpatient LCs. We applied both exclusion and inclusion criteria, an anesthetic and surgical protocol, and discharge-specific criteria. Postoperative management in "fast track" regime. Postoperative period controlled by protocol, including phone calls after cholecystectomy. Results: the ambulatory percentage in the global series was 88.8%, and mean hospital stay was 6.1 hours. Fifty-one patients required overnight stays (10.1%, most of them for "social" causes. Five patients required admission (between 24 and 48 hours for different causes (conversion to laparotomy, intraoperative neumothorax, and postoperative medical complications. Six patients (1.1% were readmitted, and we observed 11.6% postoperative complications in the global series, with abdominal parietal pain being most frequent. Phone localization by 22.00 p.m. in the same day of surgery was 100% complete for outpatient cases. Postoperative surveillance within the first month after surgery was completed in 93.9%, and within th first year in 86.7% of patients. Conclusions: outpatient LC is safe and feasible, and probably represents a new "gold standard" in the treatment of symptomatic cholelithiasis.Objetivo: aportar nuestra experiencia durante cinco años en la implantación de la colecistectomía laparoscópica (CL en un programa de cirugía mayor ambulatoria (CMA. Pacientes: entre enero de 1999 y marzo de 2004, se realizaron 504 CL consecutivas en régimen ambulatorio. Se aplicaron criterios de exclusión e inclusión, un procedimiento anestésico-quirurgico protocolizado, y criterios específicos al alta hospitalaria. El manejo postoperatorio se realizó en régimen de "fast track" o de recuperación rápida. Seguimiento postoperatorio estricto mediante protocolo de revisiones, incluido localizaci

  15. 40 CFR 63.7887 - What are the general standards I must meet for my affected equipment leak sources?

    Science.gov (United States)

    2010-07-01

    ... meet for my affected equipment leak sources? 63.7887 Section 63.7887 Protection of Environment... affected equipment leak sources? (a) You must control HAP emissions from equipment leaks from each equipment component that is part of the affected source by implementing leak detection and control measures...

  16. Energy-Efficiency Labels and Standards: A Guidebook forAppliances, Equipment, and Lighting - 2nd Edition

    Energy Technology Data Exchange (ETDEWEB)

    Wiel, Stephen; McMahon, James E.

    2005-04-28

    Energy-performance improvements in consumer products are an essential element in any government's portfolio of energy-efficiency and climate change mitigation programs. Governments need to develop balanced programs, both voluntary and regulatory, that remove cost-ineffective, energy-wasting products from the marketplace and stimulate the development of cost-effective, energy-efficient technology. Energy-efficiency labels and standards for appliances, equipment, and lighting products deserve to be among the first policy tools considered by a country's energy policy makers. The U.S. Agency for International Development (USAID) and several other organizations identified on the cover of this guidebook recognize the need to support policy makers in their efforts to implement energy-efficiency standards and labeling programs and have developed this guidebook, together with the Collaborative Labeling and Appliance Standards Program (CLASP), as a primary reference. This second edition of the guidebook was prepared over the course of the past year, four years after the preparation of the first edition, with a significant contribution from the authors and reviewers mentioned previously. Their diligent participation helps maintain this book as the international guidance tool it has become. The lead authors would like to thank the members of the Communications Office of the Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory for their support in the development, production, and distribution of the guidebook. This guidebook is designed as a manual for government officials and others around the world responsible for developing, implementing, enforcing, monitoring, and maintaining labeling and standards setting programs. It discusses the pros and cons of adopting energy-efficiency labels and standards and describes the data, facilities, and institutional and human resources needed for these programs. It provides guidance on the design

  17. Decision Making in the Management of Extracapsular Fractures of the Proximal Femur - is the Dynamic Hip Screw the Prevailing Gold Standard?

    Science.gov (United States)

    Jacob, Joshua; Desai, Ankit; Trompeter, Alex

    2017-01-01

    Currently, approximately half of all hip fractures are extracapsular, with an incidence as high as 50 in 100,000 in some countries. The common classification systems fail to explain the logistics of fracture classification and whether they all behave in the same manner. The Muller AO classification system is a useful platform to delineate stable and unstable fractures. The Dynamic hip screw (DHS) however, has remained the 'gold standard' implant of choice for application in all extracapsular fractures. The DHS relies on the integrity and strength of the lateral femoral wall as well as the postero-medial fragment. An analysis of several studies indicates significant improvements in design and techniques to ensure a better outcome with intramedullary nails. This article reviews the historical trends that helped to evolve the DHS implant as well as discussing if the surgeon should remain content with this implant. We suggest that the gold standard surgical management of extracapsular fractures can, and should, evolve.

  18. Consent for routine neonatal procedures: A study of practices in Irish neonatal units. How do we compare with the gold standard BAPM guidelines?

    Science.gov (United States)

    Ryan, M A; Ryan, C A; Dempsey, E; O'Connell, R

    2017-06-09

    The Irish National Consent Policy (NCP) proposes that the legal requirement for consent extends to all forms of interventions, investigations and treatment, carried out on or behalf of the Health Service Executive (HSE). This study employs a quantitative descriptive approach to investigate the practices for obtaining consent for an identified group of routine neonatal procedures in neonatal facilities throughout Ireland. The BAPM (British Association of Perinatal Medicine) guidelines were identified as 'gold standard' for the purposes of this study. The results indicated a lack of consistency between participating units pertaining to the modes of consent utilised and notable variances from 'gold standard' guidelines. Unanimity was evident for 3 procedures only (administering BCG, 6-in-1, and donor breast milk to infant). Significant findings related to EEG with video recordings, MRI/CT and gastro intestinal imaging, screening of an infant with suspected substance abuse or retinopathy of prematurity screening (ROP), administration of Vitamin K, and the carrying out of a lumbar puncture.

  19. Gold-Mining

    DEFF Research Database (Denmark)

    Raaballe, J.; Grundy, B.D.

    2002-01-01

      Based on standard option pricing arguments and assumptions (including no convenience yield and sustainable property rights), we will not observe operating gold mines. We find that asymmetric information on the reserves in the gold mine is a necessary and sufficient condition for the existence...... of operating gold mines. Asymmetric information on the reserves in the mine implies that, at a high enough price of gold, the manager of high type finds the extraction value of the company to be higher than the current market value of the non-operating gold mine. Due to this under valuation the maxim of market...

  20. Gold Standard Tests

    Science.gov (United States)

    2001-06-01

    a slow release caffeine . NATO - RTA - Electroencephal Clin Neurophysiol 1997;103:554- AMP Meeting, 29 Sep-3Oct 1997, Rotterdam. 62. 22. Pieron H...I1 yellow Miscellaneous Strychnine + Cannabis indica + Tobacco LI, LII + (amblyopia) Sildenafil citrate + LI, III blue, blue- flashing lights

  1. Real-time PCR to supplement gold-standard culture-based detection of Legionella in environmental samples.

    Science.gov (United States)

    Collins, S; Jorgensen, F; Willis, C; Walker, J

    2015-10-01

    Culture remains the gold-standard for the enumeration of environmental Legionella. However, it has several drawbacks including long incubation and poor sensitivity, causing delays in response times to outbreaks of Legionnaires' disease. This study aimed to validate real-time PCR assays to quantify Legionella species (ssrA gene), Legionella pneumophila (mip gene) and Leg. pneumophila serogroup-1 (wzm gene) to support culture-based detection in a frontline public health laboratory. Each qPCR assay had 100% specificity, excellent sensitivity (5 GU/reaction) and reproducibility. Comparison of the assays to culture-based enumeration of Legionella from 200 environmental samples showed that they had a negative predictive value of 100%. Thirty eight samples were positive for Legionella species by culture and qPCR. One hundred samples were negative by both methods, whereas 62 samples were negative by culture but positive by qPCR. The average log10 increase between culture and qPCR for Legionella spp. and Leg. pneumophila was 0·72 (P = 0·0002) and 0·51 (P = 0·006), respectively. The qPCR assays can be conducted on the same 1 l water sample as culture thus can be used as a supplementary technique to screen out negative samples and allow more rapid indication of positive samples. The assay could prove informative in public health investigations to identify or rule out sources of Legionella as well as to specifically identify Leg. pneumophila serogroup 1 in a timely manner not possible with culture. © 2015 The Society for Applied Microbiology.

  2. Laparoscopic inguinal hernia repair: gold standard in bilateral hernia repair? Results of more than 2800 patients in comparison to literature.

    Science.gov (United States)

    Wauschkuhn, Constantin Aurel; Schwarz, Jochen; Boekeler, Ulf; Bittner, Reinhard

    2010-12-01

    Advantages and disadvantages of open and endoscopic hernia surgery are still being discussed. Until now there has been no study that evaluated the advantages and disadvantages of bilateral hernia repair in a large number of patients. Our prospectively collected database was analyzed to compare the results of laparoscopic bilateral with laparoscopic unilateral hernia repair. We then compared these results with the results of a literature review regarding open and laparoscopic bilateral hernia repair. From April 1993 to December 2007 there were 7240 patients with unilateral primary hernia (PH) and 2880 patients with bilateral hernia (5760 hernias) who underwent laparoscopic transabdominal preperitoneal patch plastic (TAPP). Of the 10,120 patients, 28.5% had bilateral hernias. Adjusted for the number of patients operated on, the mean duration of surgery for unilateral hernia repair was shorter than that for bilateral repair (45 vs. 70 min), but period of disability (14 vs. 14 days) was the same. Adjusted for the number of hernias repaired, morbidity (1.9 vs. 1.4%), reoperation (0.5 vs. 0.43%), and recurrence rate (0.63 vs. 0.42%) were similar for unilateral versus bilateral repair, respectively. The review of the literature shows a significantly shorter time out of work after laparoscopic bilateral repair than after the bilateral open approach. Simultaneous laparoscopic repair of bilateral inguinal hernias does not increase the risk for the patient and has an equal length of down time compared with unilateral repair. According to literature, recovery after laparoscopic repair is faster than after open simultaneous repair. Laparoscopic/endoscopic inguinal hernia repair of bilateral hernias should be recommended as the gold standard.

  3. Definition of Iron Deficiency Based on the Gold Standard of Bone Marrow Iron Staining in Heart Failure Patients.

    Science.gov (United States)

    Grote Beverborg, Niels; Klip, IJsbrand T; Meijers, Wouter C; Voors, Adriaan A; Vegter, Eline L; van der Wal, Haye H; Swinkels, Dorine W; van Pelt, Joost; Mulder, Andre B; Bulstra, Sjoerd K; Vellenga, Edo; Mariani, Massimo A; de Boer, Rudolf A; van Veldhuisen, Dirk J; van der Meer, Peter

    2018-02-01

    The most commonly used definition of iron deficiency (ID; ferritin the biomarker-based definition of ID in HF, using bone marrow iron staining as the gold standard. Second, we aimed to assess the prognostic value of the optimized definition. Bone marrow aspiration with iron staining was performed in 42 patients with HF and a reduced left ventricular ejection fraction (≤45%) undergoing median sternotomy for coronary artery bypass grafting. Patients were mostly male (76%) with mild-to-moderate HF and a mean age of 68±10 years. Bone marrow ID was found in 17 (40%) of the HF patients. The most commonly used definition of ID had a sensitivity of 82% and a specificity of 72%. A definition solely based on TSAT ≤19.8% or serum iron ≤13 µmol/L had a sensitivity of 94% and specificity of 84% and 88%, respectively ( P the former definition). Subsequently, we assessed the incidence of all-cause mortality in 387 consecutive outpatient HF patients (left ventricular ejection fraction ≤45%). In these patients, TSAT ≤19.8% and serum iron ≤13 µmol/L, and not ferritin, were independently associated with mortality. A TSAT ≤19.8% or a serum iron ≤13 µmol/L shows the best performance in selecting patients with ID and identifies HF patients at the highest risk of death. Our findings validate the currently used TSAT cutoff of the identification of ID in HF patients, but question the diagnostic value of ferritin. © 2018 American Heart Association, Inc.

  4. Analytical and diagnostic performance of a qPCR assay for Ichthyophonus spp. compared to the tissue culture 'gold standard'.

    Science.gov (United States)

    Lowe, Vanessa C; Hershberger, Paul K; Friedman, Carolyn S

    2018-06-04

    Parasites of the genus Ichthyophonus infect many fish species and have a non-uniform distribution within host tissues. Due in part to this uneven distribution, the comparative sensitivity and accuracy of using molecular-based detection methods versus culture to estimate parasite prevalence is under debate. We evaluated the analytical and diagnostic performance of an existing qPCR assay in comparison to the 'gold standard' culture method using Pacific herring Clupea pallasii with known exposure history. We determined that the assay is suitable for use in this host, and diagnostic specificity was consistently high (>98%) in both heart and liver tissues. Diagnostic sensitivity could not be fully assessed due to low infection rates, but our results suggest that qPCR is not as sensitive as culture under all circumstances. Diagnostic sensitivity of qPCR relative to culture is likely affected by the amount of sample processed. The prevalence values estimated by the 2 methods were not significantly different when sample amounts were equal (heart tissue), but when the assayed sample amounts were unequal (liver tissue), the culture method detected a significantly higher prevalence of the parasite than qPCR. Further, culture of liver also detected significantly more Ichthyophonus infections than culture of heart, suggesting that the density and distribution of parasites in tissues also plays a role in assay sensitivity. This sensitivity issue would be most problematic for fish with light infections. Although qPCR does not detect the presence of a live organism, DNA-based pathogen detection methods provide the opportunity for alternate testing strategies when culture is not possible.

  5. Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort.

    Science.gov (United States)

    Li, Yu; Chen, Dong-Ning; Cui, Jing; Xin, Zhong; Yang, Guang-Ran; Niu, Ming-Jia; Yang, Jin-Kui

    2016-11-06

    Subclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TSH) levels. However, the upper limit of reference range for TSH is debated recently. This study was to determine the cutoff value for the upper normal limit of TSH in a cohort using the prevalence of Hashimoto thyroiditis as "gold" calibration standard. The research population was medical staff of 2856 individuals who took part in health examination annually. Serum free triiodothyronine (FT3), free thyroxine (FT4), TSH, thyroid peroxidase antibody (TPAb), thyroglobulin antibody (TGAb) and other biochemistry parameters were tested. Meanwhile, thyroid ultrasound examination was performed. The diagnosis of HT was based on presence of thyroid antibodies (TPAb and TGAb) and abnormalities of thyroid ultrasound examination. We used two different methods to estimate the cutoff point of TSH based on the prevalence of HT. Joinpoint regression showed the prevalence of HT increased significantly at the ninth decile of TSH value corresponding to 2.9 mU/L. ROC curve showed a TSH cutoff value of 2.6 mU/L with the maximized sensitivity and specificity in identifying HT. Using the newly defined cutoff value of TSH can detect patients with hyperlipidemia more efficiently, which may indicate our approach to define the upper limit of TSH can make more sense from the clinical point of view. A significant increase in the prevalence of HT occurred among individuals with a TSH of 2.6-2.9 mU/L made it possible to determine the cutoff value of normal upper limit of TSH.

  6. Could Serum Laminin Replace Liver Biopsy as Gold Standard for Predicting Significant Fibrosis in Patients with Chronic Hepatitis B? Clinical and Histopathological Study

    OpenAIRE

    Abeer M. Hafez; Yasser S. Sheta; Mohamed H. Ibrahim; Shereen A. Elshazly

    2013-01-01

    Background: The prognosis and clinical treatment of chronic liver disease depends greatly on the progression of liver fibrosis, which has resulted from the loss of normal liver cell function due to disorganized over-accumulation of extra-cellular matrix (ECM) components in the liver. Liver biopsy has been considered the gold standard for staging and grading hepatic fibrosis and inflammation. However, the procedure is associated with complications such as bleeding, infection, damage to liver t...

  7. 40 CFR Appendix D to Subpart B of... - SAE J2810 Standard for Recovery Only Equipment for HFC-134a Refrigerant

    Science.gov (United States)

    2010-07-01

    ... removed from, motor vehicle air-conditioning systems. 1. Scope The purpose of this SAE Standard is to... 700 Standard or allow for recycling of the recovered refrigerant to SAE J2788 specifications by using... (R-134a) Recovery/Recycling Equipment and Recovery/Recycling/Recharging for Mobile Air-Conditioning...

  8. IEEE Std 600: IEEE trial-use standard requirements for organizations that conduct qualification testing of safety systems equipment for use in nuclear power generating stations

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    The purpose of this standard is to provide requirements for establishing a program for conducting qualification tests of safety systems equipment used in nuclear power generating stations. Compliance with the requirements of this standard does not assure the adequacy of the qualification tests performed. This standard applies to organizations that conduct qualification tests on equipment that has a definable safety function and is an identifiable part of a safety system for use in nuclear power generating stations. It requires a technical program, a quality assurance program, and a demonstrated ability to meet specified technical requirements. It does not apply to materials tests, production tests, normal performance testing, qualification by analysis, qualification by operating experience, or reliability tests such as diesel-generator multiple start tests. The intent of this standard is to achieve greater consistency, reliability, and reproducibility of test results and to provide adequate control of qualification testing of safety systems equipment

  9. 40 CFR 63.1298 - Standards for slabstock flexible polyurethane foam production-HAP emissions from equipment cleaning.

    Science.gov (United States)

    2010-07-01

    ... polyurethane foam production-HAP emissions from equipment cleaning. 63.1298 Section 63.1298 Protection of... foam production—HAP emissions from equipment cleaning. Each owner or operator of a new or existing...(a)(1) shall not use a HAP or a HAP-based material as an equipment cleaner. ...

  10. 40 CFR 63.1296 - Standards for slabstock flexible polyurethane foam production-HAP ABA equipment leaks.

    Science.gov (United States)

    2010-07-01

    ... polyurethane foam production-HAP ABA equipment leaks. 63.1296 Section 63.1296 Protection of Environment... production—HAP ABA equipment leaks. Each owner or operator of a new or existing slabstock affected source complying with the emission point specific limitation option provided in § 63.1293(a) shall control HAP ABA...

  11. The development of the American national standard, ''control of radioactive surface contamination on materials, equipment and facilities to be released for uncontrolled use''

    International Nuclear Information System (INIS)

    Shapiro, J.

    1980-01-01

    The American National Standard, Control of Radioactive Surface Contamination on Materials, Equipment and Facilities to be Released for Uncontrolled Use, was developed under the procedures of ANSI for ANSI Main Committee N13 (Radiation Protection) by a working group of the Health Physics Society Standards Committee. This standard provides criteria for the control of materials, equipment and facilities contaminated with radioactivity proposed to be released for uncontrolled use. Permissible contamination limits are specified as well as methods assessing the levels of contamination. This paper reviews the proceedings of the Subcommittee on Radioactive Surface Contamination, the comments received by reviewers of the standard, the resolution of the committee, and the bases for reaching the final limits, recommendations, and measurement procedures. (H.K.)

  12. Certification of boiler safety equipment with ALSPA P320 system, to IEC 61508 standard; Certification des equipements de securite chaudiere avec le systeme ALSPA P320 selon la norme IEC 61508

    Energy Technology Data Exchange (ETDEWEB)

    Dalzon, J.P. [Alstom Power (France)

    2002-02-01

    Safety and environmental protection are major priorities governing Alstom work on control systems (Alspa P320) for power plant applications, especially when potentially dangerous processes like high-power flame boilers (typically rated at 100 to 600 MW) are involved. Here, automatic protection chains are implemented to guard against the risk of serious incident such as explosion and equipment destruction. In this kind of situation, the IEC 61508 standard provides baseline specifications for certification of safety systems. (authors)

  13. Chapter 5. Essential equipment, pharmaceuticals and supplies. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster

    NARCIS (Netherlands)

    Sprung, Charles L.; Kesecioglu, Jozef; Christian, Michael D.; Camargo, Ruben; Ceraso, Daniel; Azoulay, Elie; Duguet, Alexandre; Guery, Benoit; Reinhart, Konrad; Adini, Bruria; Barlavie, Yaron; Benin-Goren, Odeda; Cohen, Robert; Klein, Motti; Leoniv, Yuval; Margalit, Gila; Rubinovitch, Bina; Sonnenblick, Moshe; Steinberg, Avraham; Weissman, Charles; Wolff, Donna; de Jong, Menno; Moreno, Rui; An, Youzhong; Du, Bin; Joynt, Gavin M.; Colvin, John; Loo, Shi; Richards, Guy; Artigas, Antonio; Pugin, Jerome; Amundson, Dennis; Devereaux, Asha; Beigel, John; Danis, Marion; Farmer, Chris; Hick, John L.; Maki, Dennis; Masur, Henry; Rubinson, Lewis; Sandrock, Christian; Talmor, Daniel; Truog, Robert; Zimmerman, Janice; Brett, Steve; Montgomery, Hugh; Rhodes, Andrew; Sanderson, Frances; Taylor, Bruce

    2010-01-01

    To provide recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza pandemic or mass disaster with a specific focus on essential equipment, pharmaceuticals and supplies. Based on a literature review and expert opinion, a Delphi process was

  14. Safety Analysis of 'Older/Aged' Handling and Transportation Equipment for Heavy Loads, Radioactive Waste and Materials in Accordance with German Nuclear Standards KTA 3902, 3903 and 3905

    International Nuclear Information System (INIS)

    Macias, P.; Prucker, E.; Stang, W.

    2006-01-01

    The purpose of this paper is to present a general safety analysis of important handling and transportation processes and their related equipment ('load chains' consisting of cranes, load-bearing equipment and load-attaching points). This project was arranged by the responsible Bavarian ministry for environment, health and consumer protection (StMUGV) in agreement with the power plant operators of all Bavarian nuclear power plants to work out potential safety improvements. The range of the equipment (e.g. reactor building, crane, refuelling machine, load-bearing equipment and load-attaching points) covers the handling and transportation of fuel elements (e. g. with fuel flasks), heavy loads (e.g. reactor pressure vessel closure head, shielding slabs) and radioactive materials and waste (e.g. waste flasks, control elements, fuel channels, structure elements). The handling equipment was subjected to a general safety analysis taking into account the ageing of the equipment and the progress of standards. Compliance with the current valid requirements of the state of science and technology as required by German Atomic Act and particularly of the nuclear safety KTA-standards (3902, 3903 and 3905) was examined. The higher protection aims 'safe handling and transportation of heavy loads and safe handling of radioactive materials and waste' of the whole analysis are to avoid a criticality accident, the release of radioactivity and inadmissible effects on important technical equipment and buildings. The scope of the analysis was to check whether these protection aims were fulfilled for all important technical handling and transportation processes. In particularly the design and manufacturing of the components and the regulations of the handling itself were examined. (authors)

  15. Field Demonstration of Active Desiccant Modules Designed to Integrate with Standard Unitary Rooftop Package Equipment - Final Report: Phase 3

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, J

    2004-03-15

    This report summarizes the investigation of two active desiccant module (ADM) pilot site installations initiated in 2001. Both pilot installations were retrofits at existing facilities served by conventional heating, ventilating, and air-conditioning (HVAC) systems that had encountered frequent humidity control, indoor air quality (IAQ), and other operational problems. Each installation involved combining a SEMCO, Inc., ADM (as described in Fischer and Sand 2002) with a standard packaged rooftop unit built by the Trane Company. A direct digital control (DDC) system integral to the ADM performed the dual function of controlling the ADM/rooftop combination and facilitating data collection, trending, and remote performance monitoring. The first installation involved providing preconditioned outdoor air to replace air exhausted from the large kitchen hood and bathrooms of a Hooters restaurant located in Rome, Georgia. This facility had previously added an additional rooftop unit in an attempt to achieve occupant comfort without success. The second involved conditioning the outdoor air delivered to each room of a wing of the Mountain Creek Inn at the Callaway Gardens resort. This hotel, designed in the ''motor lodge'' format with each room opening to the outdoors, is located in southwest Georgia. Controlling the space humidity always presented a serious challenge. Uncomfortable conditions and musty odors had caused many guests to request to move to other areas within the resort. This is the first field demonstration performed by Oak Ridge National Laboratory where significant energy savings, operating cost savings, and dramatically improved indoor environmental conditions can all be claimed as the results of a retrofit desiccant equipment field installation. The ADM/rooftop combination installed at the restaurant resulted in a reduction of about 34% in the electricity used by the building's air-conditioning system. This represents a reduction of

  16. Survey and assessment of support for non-standard (anomalous) stope areas in the gold and platinum industry.

    CSIR Research Space (South Africa)

    Leach, AR

    2002-12-01

    Full Text Available of depth below surface Figure 2.5 Contributing factors to 89 accident incidents as a function of reef Figure 2.6 Relative proportion of key factors contributing to anomalous conditions on the VCR, as determined from 28 incidents Figure 3.1 Location... to correctly recognise and address problems. The project considers gold mines in the Witwatersrand basin and platinum mines in the Bushveld Igneous Complex, at all depths from near surface to in excess of 3500 m, on a range of economically important reefs...

  17. The euro and the recent European crisis vis-à-vis the gold standard and the great depression: institutionalities, specificities and interfaces

    Directory of Open Access Journals (Sweden)

    GIULIANO CONTENTO DE OLIVEIRA

    Full Text Available ABSTRACT The paper aims to establish interfaces between the Great Depression of the 1930s under the Gold Standard and the recent European Crisis under the Euro. It is argued that, despite their specificities, both crises revealed the potentially harmful effects, in economic and social terms, of institutional arrangements that considerably reduce the autonomy of monetary, fiscal and exchange rate policies of participating countries, without being accompanied by increased cooperation between them, which should be led by a global (in the case of the Great Depression or regional (in the case of the European Crisis hegemonic power, which is not only capable of, but is also willing to act as a buyer and lender of last resort, especially in circumstances characterized by increased uncertainty, the deterioration of the general state of expectations and increased liquidity preference. In fact, central European countries in the past and peripheral European countries nowadays were effectively pushed toward deflationary adjustments in which a reduction of prices and wages was accompanied by a reduction of output and employment levels. Thus, in the absence of the possibility of restoring the autonomy of economic policy, the overcome of the crisis necessarily requires, both before - under the Gold Standard - and nowadays - under the Euro -, joint actions aimed to assure that the responsibility for the adjustment will be equally distributed among all the economies, in order to avoid that some of them benefit at the expense of the others in this process.

  18. Changing organizational culture: using the CEO cancer gold standard policy initiatives to promote health and wellness at a school of public health.

    Science.gov (United States)

    Towne, Samuel D; Anderson, Kelsey E; Smith, Matthew Lee; Dahlke, Deborah Vollmer; Kellstedt, Debra; Purcell, Ninfa Pena; Ory, Marcia G

    2015-09-03

    Worksite wellness initiatives for health promotion and health education have demonstrated effectiveness in improving employee health and wellness. We examined the effects of a multifaceted health promotion campaign on organizational capacity to meet requirements to become CEO Cancer Gold Standard Accredited. We conducted an online survey to assess perceived organizational values and support for the five CEO Cancer Gold Standard Pillars for cancer prevention: tobacco cessation; physical activity; nutrition; cancer screening and early detection; and accessing information on cancer clinical trials. Baseline and follow-up surveys were sent 6-months apart to faculty, staff, and students at a school of public health to test the impact of a multifaceted health promotion campaign on perceived organizational change. Descriptive analyses were used to characterize percent improvement. Multivariate logistic regression analyses were used to control for participants' university status. The current organizational culture highly supported tobacco cessation at both time points. Significant improvements (p screening, and early detection of cancer' and 'accessing cancer treatment and clinical trials'. Health promotion and education efforts using multiple approaches were effective to improve perceived organizational values and support for cancer prevention and early detection, and increase access to information about cancer clinical trials. Future studies are needed to examine broader impacts of implementing worksite health promotion initiatives.

  19. Transvaginal duplex ultrasonography appears to be the gold standard investigation for the haemodynamic evaluation of pelvic venous reflux in the ovarian and internal iliac veins in women.

    Science.gov (United States)

    Whiteley, M S; Dos Santos, S J; Harrison, C C; Holdstock, J M; Lopez, A J

    2015-12-01

    To assess the suitability of transvaginal duplex ultrasonography to identify pathological reflux in the ovarian and internal iliac veins in women. A retrospective study of patients treated in 2011 and 2012 was performed in a specialised vein clinic. Diagnostic transvaginal duplex ultrasonography in women presenting with symptoms or signs of pelvic vein reflux were compared with the outcomes of treatment from pelvic vein embolisation. A repeat transvaginal duplex ultrasonography was performed 6 weeks later by a blinded observer and any residual reflux was identified. Results from 100 sequential patients were analysed. Mean age 44.2 years (32-69) with mode average parity of 3 (0-5 deliveries). Pre-treatment, 289/400 veins were refluxing (ovarian - 29 right, 81 left; internal iliac - 93 right, 86 left). Coil embolisation was successful in 86/100 patients and failed partially in 14/100 - 5 due to failure to cannulate the target vein. One false-positive diagnosis was made. Currently there is no accepted gold standard for pelvic vein incompetence. Comparing transvaginal duplex ultrasonography with the outcome from selectively treating the veins identified as having pathological reflux with coil embolisation, there were no false-negative diagnoses and only one false-positive. This study suggests that transvaginal duplex ultrasonography could be the gold standard in assessing pelvic vein reflux. © The Author(s) 2014.

  20. Construction and equipment requirements for installations and laboratories handling unsealed radioactive materials in low and medium activity - Proposal of an Israeli standard

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Shlomo, A; Schlesinger, T; Barshad, M [Soreq Nuclear Research Center, Yavne (Israel)

    1993-10-01

    Working with unsealed radioactive materials involves risks of internal or external exposure to ionizing radiation. Exposure of human beings to ionizing radiation involves adverse health effects and must be prevented or at least reduced to reasonable levels. Radiation sources in this work are unsealed radioactive materials, that may be solids, liquid or in gaseous states, and in varying toxic levels. Various works and actions that are performed on the unsealed radioactive materials have varying potentials of dispersion, contamination and exposure, so that the combination of the type of work activity, isotope characteristics and physical state dictate the internal and external exposure risks. In order to limit the exposure of the personnel of installations and laboratories which deals with unsealed radioactive materials, national and international authorities and organizations standards and procedures for the requirements of construction and equipment of such installations and laboratories. This document means to be a proposal for an Israeli standard requirements for equipment and construction of installations working with low and medium activity unsealed radioactive materials. The targets for defining the, construction and equipment, requirements are: a. Safety and proper protection of personnel and public from external and internal exposure while the work is done properly. Proper protection against the risk of contaminating the environment. c. Standardization of requirements. d. Proper design of installations and laboratories. e. Supply means for evaluation and reduction of construction costs.The equipment detailed here refers to fixed (none movable) equipment which is a part of the construction of the laboratory or installation, unless specified otherwise. The document starts with a review of the recommendations of some international organizations (WHO, IAEA, NRPB) for construction and equipment requirements for these laboratories and installations. Then the

  1. The development of the American National Standard 'control of radioactive surface contamination on materials equipment and facilities to be released for uncontrolled use'

    International Nuclear Information System (INIS)

    Shapiro, J.

    1980-01-01

    A new standard submitted by the Health Physics Society Standards Committee to the American National Standards Institute concerning radioactive surface contamination of materials and equipment is discussed. The chronological events in the development of this standard are given. The standard provides criteria for the release for uncontrolled use of materials, equipment and facilities contaminated or potentially contaminated with radioactivity. Permissible contamination limits are specified for: 1) long lived alpha emitters except natural uranium and thorium, 2) more hazardous beta-gamma emitters, 3) less hazardous beta-gamma emitters and 4) natural uranium and thorium. A contamination reference level of 1000 dpm/100 cm 2 for 90 Sr was set as the basis for assigning limits to radionuclides presenting an ingestion hazard and other radionuclides were grouped based on the values of their maximum permissible concentration (MPC) in water relative to 90 Sr. The contamination limit for 239 Pu was chosen as the basis for assigning limits based on MPC in air to radionuclides presenting an inhalation hazard; a value of 100 dpm/100 cm 2 was adopted in the standard. An upper limit of 5000 dpm/100 cm 2 for surface contamination was selected for the standard. (UK)

  2. Quantification of captopril in urine through surface-assisted laser desorption/ionization mass spectrometry using 4-mercaptobenzoic acid-capped gold nanoparticles as an internal standard.

    Science.gov (United States)

    Chen, Wen-Tsen; Chiang, Cheng-Kang; Lin, Yang-Wei; Chang, Huan-Tsung

    2010-05-01

    We have developed a new internal standard method for the determination of the concentration of captopril (CAP) through surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using gold nanoparticles (Au NPs). This approach provided linearity for CAP over the concentration range 2.5-25 microM (R(2) = 0.987), with a limit of detection (signal-to-noise ratio = 3) of 1.0 microM. The spot-to-spot variations in the concentration of CAP through SALDI-MS analyses performed in the absence and presence of the internal standard were 26% and 9%, respectively (15 measurements). This approach provides simplicity, accuracy, precision, and great reproducibility to the determination of the levels of CAP in human urine samples. Copyright 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.

  3. A locking compression plate versus the gold-standard non-locking plate with lag screw for first metatarsophalangeal fusion: A biomechanical comparison.

    Science.gov (United States)

    Mandell, Daniel; Karbassi, John; Zhou, Hanbing; Burroughs, Brian; Aurigemma, Philip; Patel, Abhay R

    2018-03-01

    The treatment of end-stage first metatarso-phalangeal joint (MTP) arthritis has been arthrodesis. A dorsal non-locking plate with a lag screw has been the standard traditional fixation method. This study compares the biomechanical strength of a locking compression plate (LCP) with and without internal compression versus this known gold standard. In group 1, six matched pairs of cadaver great toes were used to compare the standard non-locking dorsal plate and 3.5mm lag screw to an anatomic locking compression plate in which a lag screw was utilized rather than the internal compression features of the plate. In group 2, another six matched pairs of cadaver great toes were used to compare the gold standard to the locking compression plate, utilizing the plate's internal compression feature instead of a lag screw. A material testing system (MTS) machine applied loads to the MTP joints and measured displacement and stiffness of the constructs. The stiffness of the constructs (Young's modulus) was calculated from the force-displacement curves, and the displacement was measured. The locking compression plate group that used the compression features of the plate, without the lag screw, had less joint displacement and higher stiffness than control (p<0.05). The same plating construct in which a lag screw was used rather than internal compression of the plate was found to be stiffer than the control (p<0.05), but displacement was not statistically significant. The results suggest that a locking compression plate alone provides the stiffest construct for a first MTP joint fusion. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Evaluation of secondary ion yield enhancement from polymer material by using TOF-SIMS equipped with a gold cluster ion source

    Energy Technology Data Exchange (ETDEWEB)

    Aimoto, K. [Department of Applied Physics, Faculty of Engineering, Seikei University, 3-3-1 Kichijioji-Kitamachi, Musashino-shi, Tokyo 180-8633 (Japan)]. E-mail: dm053502@cc.seikei.ac.jp; Aoyagi, S. [Department of Regional Development, Faculty of Life and Environmental Science, Shimane University, 1060 Nishikawatsu-cho, Matsue-shi, Shimane 690-8504 (Japan); Kato, N. [Department of Applied Physics, Faculty of Engineering, Seikei University, 3-3-1 Kichijioji-Kitamachi, Musashino-shi, Tokyo 180-8633 (Japan); Iida, N. [ULVAC-PHI, Inc., 370 Enzo, Chigasaki, Kanagawa 253-0084 (Japan); Yamamoto, A. [ULVAC-PHI, Inc., 370 Enzo, Chigasaki, Kanagawa 253-0084 (Japan); Kudo, M. [Department of Applied Physics, Faculty of Engineering, Seikei University, 3-3-1 Kichijioji-Kitamachi, Musashino-shi, Tokyo 180-8633 (Japan)

    2006-07-30

    We investigated the enhancement of the secondary ion intensity in the TOF-SIMS spectra obtained by Au{sup +} and Au{sub 3} {sup +} bombardment in comparison with Ga{sup +} excitation using polymer samples with different molecular weight distributions. Since the polymer samples used in this experiment have a wide molecular weight distribution, the advantages of the gold cluster primary ion source over monoatomic ion could accurately be evaluated. It was observed that the degree of fragmentation decreased by the usage of cluster primary ion beam compared with monoatomic ion beam, which was observed as a shift of the intensity distribution in the spectra. It was also found out that the mass effect of Au{sup +} and Ga{sup +} as monoatomic primary ion, resulted in about 10-60 times of enhancement for both samples with different molecular distributions. On the other hand, the Au{sub 3} {sup +} bombardment caused intensity enhancement about 100-2600 compared with Ga{sup +} bombardment, depending on the mass range of the detected secondary ion species. The cluster primary ion effect of Au{sub 3} {sup +}, compared with Au{sup +}, therefore, was estimated to be about 10-45.

  5. Produce Live News Broadcasts Using Standard AV Equipment: A Success Story from the Le Center High School in Minnesota.

    Science.gov (United States)

    Rostad, John

    1997-01-01

    Describes the production of news broadcasts on video by a high school class in Le Center, Minnesota. Topics include software for Apple computers, equipment used, student responsibilities, class curriculum, group work, communication among the production crew, administrative and staff support, and future improvements. (LRW)

  6. 77 FR 37734 - Technical Standard Order (TSO) C-122a, Equipment That Prevent Blocked Channels Used in Two-Way...

    Science.gov (United States)

    2012-06-22

    ... address, weekdays except federal holidays, between 8:30 a.m. and 4:30 p.m. The Director, Aircraft Certification Service, will consider all comments received on or before the closing date. Background In 1984... obsolescence of TSO-C122a equipment and the lack of industry interest in new TSO-C122a product designs. We...

  7. Decision Making in the Management of Extracapsular Fractures of the Proximal Femur – is the Dynamic Hip Screw the Prevailing Gold Standard?

    Science.gov (United States)

    Jacob, Joshua; Desai, Ankit; Trompeter, Alex

    2017-01-01

    Currently, approximately half of all hip fractures are extracapsular, with an incidence as high as 50 in 100,000 in some countries. The common classification systems fail to explain the logistics of fracture classification and whether they all behave in the same manner. The Muller AO classification system is a useful platform to delineate stable and unstable fractures. The Dynamic hip screw (DHS) however, has remained the ‘gold standard’ implant of choice for application in all extracapsular fractures. The DHS relies on the integrity and strength of the lateral femoral wall as well as the postero-medial fragment. An analysis of several studies indicates significant improvements in design and techniques to ensure a better outcome with intramedullary nails. This article reviews the historical trends that helped to evolve the DHS implant as well as discussing if the surgeon should remain content with this implant. We suggest that the gold standard surgical management of extracapsular fractures can, and should, evolve. PMID:29290858

  8. GCSE and A Level Reform: Are the New Qualifications Returning a "Gold Standard" of Assessment? Election Factsheet

    Science.gov (United States)

    Burdett, Newman

    2015-01-01

    This election factsheet highlights the following points: (1) While the GCSE pass rate has increased since its introduction, this doesn't tell us very much about how standards have changed. Evidence from international surveys suggests that education standards have remained stable. Stopping the use of modules and limiting resits is likely to reduce…

  9. Standardized Laboratory Test Requirements for Hardening Equipment to Withstand Wave Impact Shock in Small High Speed Craft

    Science.gov (United States)

    2017-02-06

    axes. DRAFT NSWCCD-80-TR-2017/002 8 REFERENCES 1. Du Cane, P., The Planing Performance, Pressures , and Stresses in a High -Speed...Characterization of Individual Wave Slam Acceleration Responses for High Speed Craft, Proceedings of the 29 th American Towing Tank Conference...Methodologies for Small High -Speed Craft Structure, Equipment, Shock Isolation Seats, and Human Performance At-Sea, 10 th Symposium on High

  10. Treating the binge or the (fat) body? Representations of fatness in a gold standard psychological treatment manual for binge eating disorder.

    Science.gov (United States)

    Brown-Bowers, Amy; Ward, Ashley; Cormier, Nicole

    2017-01-01

    This article reports the results of a Foucauldian-informed discourse analysis exploring representations of fatness embedded within an empirically based psychological treatment manual for binge eating disorder, a condition characterized by overvaluation of weight and shape. Analyses indicate that the manual prioritizes weight loss with relatively less emphasis placed on treating the diagnostic symptoms and underlying mechanisms of binge eating disorder. We raise critical concerns about these observations and link our findings to mainstream psychology's adoption of the medical framing of fatness as obesity within the "gold standard" approach to intervention. We recommend that psychology as a discipline abandons the weight loss imperative associated with binge eating disorder and fat bodies. We recommend that practitioners locate the problem of fat shame in society as opposed to the individual person's body and provide individuals with tools to identify and resist fat stigma and oppression, rather than provide them with tools to reshape their bodies.

  11. Performance evaluation of direct saline stool microscopy, Formol ether concentration and Kato Katz diagnostic methods for intestinal parasitosis in the absence of gold standard methods.

    Science.gov (United States)

    Hailu, Tadesse; Abera, Bayeh

    2015-07-01

    The parasite load within the sample and the amount of sample taken during examination greatly compromise the sensitivity of direct saline stool microscopy. A cross-sectional study was conducted in March 2011 in Bahir Dar city among 778 fresh single stool samples to evaluate the performance of direct saline (DS), Kato Katz (KK) and Formol ether concentration (FEC) methods against the 'Gold' standard. Among 778 stool samples from school age children, the highest prevalence of intestinal parasites was recorded by FEC (55.1%). The sensitivity of DS, FEC and KK were 61.1%, 92.3% and 58.7%, respectively. FEC is more sensitive than DS and KK. Hence, use of the latter is preferred. © The Author(s) 2015.

  12. Validation of different measures of insulin sensitivity of glucose metabolism in dairy cows using the hyperinsulinemic euglycemic clamp test as the gold standard.

    Science.gov (United States)

    De Koster, J; Hostens, M; Hermans, K; Van den Broeck, W; Opsomer, G

    2016-10-01

    The aim of the present research was to compare different measures of insulin sensitivity in dairy cows at the end of the dry period. To do so, 10 clinically healthy dairy cows with a varying body condition score were selected. By performing hyperinsulinemic euglycemic clamp (HEC) tests, we previously demonstrated a negative association between the insulin sensitivity and insulin responsiveness of glucose metabolism and the body condition score of these animals. In the same animals, other measures of insulin sensitivity were determined and the correlation with the HEC test, which is considered as the gold standard, was calculated. Measures derived from the intravenous glucose tolerance test (IVGTT) are based on the disappearance of glucose after an intravenous glucose bolus. Glucose concentrations during the IVGTT were used to calculate the area under the curve of glucose and the clearance rate of glucose. In addition, glucose and insulin data from the IVGTT were fitted in the minimal model to derive the insulin sensitivity parameter, Si. Based on blood samples taken before the start of the IVGTT, basal concentrations of glucose, insulin, NEFA, and β-hydroxybutyrate were determined and used to calculate surrogate indices for insulin sensitivity, such as the homeostasis model of insulin resistance, the quantitative insulin sensitivity check index, the revised quantitative insulin sensitivity check index and the revised quantitative insulin sensitivity check index including β-hydroxybutyrate. Correlation analysis revealed no association between the results obtained by the HEC test and any of the surrogate indices for insulin sensitivity. For the measures derived from the IVGTT, the area under the curve for the first 60 min of the test and the Si derived from the minimal model demonstrated good correlation with the gold standard. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Immense random colocalization, revealed by automated high content image cytometry, seriously questions FISH as gold standard for detecting EML4-ALK fusion.

    Science.gov (United States)

    Smuk, Gábor; Tornóczky, Tamás; Pajor, László; Chudoba, Ilse; Kajtár, Béla; Sárosi, Veronika; Pajor, Gábor

    2018-05-19

    EML4-ALK gene fusion (inv2(p21p23)) of non-small cell lung cancer (NSCLC) predisposes to tyrosine kinase inhibitor treatment. One of the gold standard diagnostics is the dual color (DC) break-apart (BA) FISH technique, however, the unusual closeness of the involved genes has been suggested to raise likelihood of random co-localization (RCL) of signals. Although this is suspected to decrease sensitivity (often to as low as 40-70%), the exact level and effect of RCL has not been revealed thus far. Signal distances were analyzed to the 0.1 µm precision in more than 25,000 nuclei, via automated high content-image cytometry. Negative and positive controls were created using conventional DC BA-, and inv2(p21p23) mimicking probe-sets, respectively. Average distance between red and green signals was 9.72 pixels (px) (±5.14px) and 3.28px (±2.44px), in positives and negatives, respectively; overlap in distribution being 41%. Specificity and sensitivity of correctly determining ALK status was 97% and 29%, respectively. When investigating inv2(p21p23) with DC BA FISH, specificity is high, but seven out of ten aberrant nuclei are inevitably falsely classified as negative, due to the extreme level of RCL. Together with genetic heterogeneity and dilution effect of non-tumor cells in NSCLC, this immense analytical false negativity is the primary cause behind the often described low diagnostic sensitivity. These results convincingly suggest that if FISH is to remain a gold standard for detecting the therapy relevant inv(2), either a modified evaluation protocol, or a more reliable probe-design should be considered than the current DC BA one. © 2018 International Society for Advancement of Cytometry. © 2018 International Society for Advancement of Cytometry.

  14. Standardization of radiochemical techniques aiming the study of Hg volatilization and methylation in water and sediment of gold mining areas in the Amazon region

    International Nuclear Information System (INIS)

    Guimaraes, Jean Remy Davee

    1992-09-01

    Methylation of inorganic Hg in aquatic systems is a key process in the environmental cycling of this metal, not yet studied in tropical conditions. Radiochemical techniques were adapted and simplified, aiming at the study of Hg volatilization and methylation in water and sediment of gold mining areas in the Amazon region. Preliminary experiments showed, in 35 days volatilization of up to 32 % of 203 Hg 2+ added to aqueous solutions. Acid K 2 Cr 2 0 7 0.1 M solutions were not effective in 203 Hg 0 trapping and the latter was highly and irreversibly absorbed by a variety of synthetic materials commonly used in laboratory work. Considerably simplified versions of the Furutani and Rudd (1980) radiochemical technique for the determination of methylation rates in environmental samples were developed and showed efficiencies close to 90 % in tests with methyl- 2 0 3 H g standards. In-situ incubations of surface sediments were performed in the Madeira River gold mining region, Rondonia State, Brazil, and potential net Hg methylation rates (MR) of up to 1 %.g-1.h-1 were found in black-water affluent like the Mutum-Parana and Jamari rivers and in the Samuel reservoir. MRs in the Madeira River sediments were lower, ranging 10-5 to 10-3 %.g-1.h-1 . MRs obtained in incubations of samples some weeks after collection were one or two orders of magnitude lower than those resulting from in-situ incubations. Methylation in autoclaved samples was close to minimum detectable rates. MRs in surface water samples was in all cases < 7.10-7 %.ml-1.h-1. The determination of the predominant methylation sites will allow a better standardization of the technique described herein, suitable for MR determinations even under the unfavorable conditions prevailing in the Amazon region. (author)

  15. Gold prices

    OpenAIRE

    Joseph G. Haubrich

    1998-01-01

    The price of gold commands attention because it serves as an indicator of general price stability or inflation. But gold is also a commodity, used in jewelry and by industry, so demand and supply affect its pricing and need to be considered when gold is a factor in monetary policy decisions.

  16. Standard operational radiation protection instructions for process instrumentation and control engineering applying radiometric equipment containing sealed sources

    International Nuclear Information System (INIS)

    1989-01-01

    According to article 16(3) of the Ordinance on the Implementation of Atomic Safety and Radiation Protection of 11 October 1984, operational radiation protection instructions have to be worked out for each type of nuclear energy application. Based on the valid legal provisions of the GDR and on experience and knowledge gained in practice, the most important operational instructions and procedures for the operation of radiometric equipment containing sealed sources were compiled. The example should enable the management to make the instructions directly applicable and, if necessary, to modify or supplement them

  17. Gold internal standard correction for elemental imaging of soft tissue sections by LA-ICP-MS: element distribution in eye microstructures.

    Science.gov (United States)

    Konz, Ioana; Fernández, Beatriz; Fernández, M Luisa; Pereiro, Rosario; González, Héctor; Alvarez, Lydia; Coca-Prados, Miguel; Sanz-Medel, Alfredo

    2013-04-01

    Laser ablation coupled to inductively coupled plasma mass spectrometry has been developed for the elemental imaging of Mg, Fe and Cu distribution in histological tissue sections of fixed eyes, embedded in paraffin, from human donors (cadavers). This work presents the development of a novel internal standard correction methodology based on the deposition of a homogeneous thin gold film on the tissue surface and the use of the (197)Au(+) signal as internal standard. Sample preparation (tissue section thickness) and laser conditions were carefully optimized, and internal normalisation using (197)Au(+) was compared with (13)C(+) correction for imaging applications. (24)Mg(+), (56)Fe(+) and (63)Cu(+) distributions were investigated in histological sections of the anterior segment of the eye (including the iris, ciliary body, cornea and trabecular meshwork) and were shown to be heterogeneously distributed along those tissue structures. Reproducibility was assessed by imaging different human eye sections from the same donor and from ten different eyes from adult normal donors, which showed that similar spatial maps were obtained and therefore demonstrate the analytical potential of using (197)Au(+) as internal standard. The proposed analytical approach could offer a robust tool with great practical interest for clinical studies, e.g. to investigate trace element distribution of metals and their alterations in ocular diseases.

  18. Investigation of widely used nanomaterials (TiO{sub 2}, Ag) and gold nanoparticles in standardized ecotoxicological tests

    Energy Technology Data Exchange (ETDEWEB)

    Hund-Rinke, Kerstin; Klawonn, Thorsten [Fraunhofer-Institut fuer Molekularbiologie und Angewandte Oekologie (IME), Schmallenberg (Germany)

    2013-04-15

    nanomaterial gold. Since ecotoxicological data based on standardised test methods, as requested for risk assessment, are not available for these substances, and information on modifications to standardised procedures for testing nanoparticles is lacking, the aim of the present project was to contribute to the following topics: - Recommendations concerning the improvement of existing OECD Test Guidelines for the testing of nanoparticles; - Recommendations on the application of the investigated nanoparticles to the test medium; - Ecotoxicity of TiO{sub 2} and Ag nanoparticles with respect to: Earthworm reproduction, Respiration rate of soil microflora, Nitrification of soil microflora, Growth of plants, Reproduction of chironomids, Reproduction of daphnids. - Ecotoxicity of gold with respect to: Growth of algae, Immobilisation of daphnids, Development of fish embryos, Reproduction of chironomids. As a first step in the present project the German Federal Environment Agency selected several nanoparticles from the priority list of the OECD Sponsorship Programme, and the tests that should be performed with these nanoparticles were selected on the basis of available informa-tion and priority.

  19. GRIP: A web-based system for constructing Gold Standard datasets for protein-protein interaction prediction

    Directory of Open Access Journals (Sweden)

    Zheng Huiru

    2009-01-01

    Full Text Available Abstract Background Information about protein interaction networks is fundamental to understanding protein function and cellular processes. Interaction patterns among proteins can suggest new drug targets and aid in the design of new therapeutic interventions. Efforts have been made to map interactions on a proteomic-wide scale using both experimental and computational techniques. Reference datasets that contain known interacting proteins (positive cases and non-interacting proteins (negative cases are essential to support computational prediction and validation of protein-protein interactions. Information on known interacting and non interacting proteins are usually stored within databases. Extraction of these data can be both complex and time consuming. Although, the automatic construction of reference datasets for classification is a useful resource for researchers no public resource currently exists to perform this task. Results GRIP (Gold Reference dataset constructor from Information on Protein complexes is a web-based system that provides researchers with the functionality to create reference datasets for protein-protein interaction prediction in Saccharomyces cerevisiae. Both positive and negative cases for a reference dataset can be extracted, organised and downloaded by the user. GRIP also provides an upload facility whereby users can submit proteins to determine protein complex membership. A search facility is provided where a user can search for protein complex information in Saccharomyces cerevisiae. Conclusion GRIP is developed to retrieve information on protein complex, cellular localisation, and physical and genetic interactions in Saccharomyces cerevisiae. Manual construction of reference datasets can be a time consuming process requiring programming knowledge. GRIP simplifies and speeds up this process by allowing users to automatically construct reference datasets. GRIP is free to access at http://rosalind.infj.ulst.ac.uk/GRIP/.

  20. Validation for 2D/3D registration II: The comparison of intensity- and gradient-based merit functions using a new gold standard data set

    International Nuclear Information System (INIS)

    Gendrin, Christelle; Markelj, Primoz; Pawiro, Supriyanto Ardjo; Spoerk, Jakob; Bloch, Christoph; Weber, Christoph; Figl, Michael; Bergmann, Helmar; Birkfellner, Wolfgang; Likar, Bostjan; Pernus, Franjo

    2011-01-01

    Purpose: A new gold standard data set for validation of 2D/3D registration based on a porcine cadaver head with attached fiducial markers was presented in the first part of this article. The advantage of this new phantom is the large amount of soft tissue, which simulates realistic conditions for registration. This article tests the performance of intensity- and gradient-based algorithms for 2D/3D registration using the new phantom data set. Methods: Intensity-based methods with four merit functions, namely, cross correlation, rank correlation, correlation ratio, and mutual information (MI), and two gradient-based algorithms, the backprojection gradient-based (BGB) registration method and the reconstruction gradient-based (RGB) registration method, were compared. Four volumes consisting of CBCT with two fields of view, 64 slice multidetector CT, and magnetic resonance-T1 weighted images were registered to a pair of kV x-ray images and a pair of MV images. A standardized evaluation methodology was employed. Targets were evenly spread over the volumes and 250 starting positions of the 3D volumes with initial displacements of up to 25 mm from the gold standard position were calculated. After the registration, the displacement from the gold standard was retrieved and the root mean square (RMS), mean, and standard deviation mean target registration errors (mTREs) over 250 registrations were derived. Additionally, the following merit properties were computed: Accuracy, capture range, number of minima, risk of nonconvergence, and distinctiveness of optimum for better comparison of the robustness of each merit. Results: Among the merit functions used for the intensity-based method, MI reached the best accuracy with an RMS mTRE down to 1.30 mm. Furthermore, it was the only merit function that could accurately register the CT to the kV x rays with the presence of tissue deformation. As for the gradient-based methods, BGB and RGB methods achieved subvoxel accuracy (RMS m

  1. Plasmonic properties of gold-coated nanoporous anodic alumina ...

    Indian Academy of Sciences (India)

    gold-coated NAA is strongly quenched due to the strong plasmonic coupling. Keywords. Plasmon ... When coated by a thin film of gold, these templates can support surface plasmon resonance. ... 2.2 Equipment for characterization. Surface ...

  2. Simple visual review of pre- to post-operative renal ultrasound images predicts pyeloplasty success equally as well as geometric measurements: A blinded comparison with a gold standard.

    Science.gov (United States)

    Kern, Adam J M; Schlomer, Bruce J; Timberlake, Matthew D; Peters, Craig A; Hammer, Matthew R; Jacobs, Micah A

    2017-08-01

    MAG3 diuretic renal scan remains the gold standard for determination of improvement in renal drainage following pyeloplasty for ureteropelvic junction obstruction. We hypothesized that (i) a change in geometric measurements between pre-operative and post-operative renal ultrasound (RUS) images and (ii) blinded simple visual review of images both would predict pyeloplasty success. To determine if simple visual review and/or novel geometric measurement of renal ultrasounds can detect pyeloplasty failure. This study was a retrospective, blinded comparison with a gold standard. Included were children aged ≤18 years undergoing pyeloplasty at our institution from 2009 to 2015. For each kidney, representative pre-operative and post-operative RUS images were chosen. Our standard for pyeloplasty success was improved drainage curve on MAG3 and lack of additional surgery. Measurements for collecting system circularity, roundness, and renal parenchymal to collecting system area ratio (RPCSR) were obtained by three raters (Figure), who were blinded to the outcome of the pyeloplasty. Changes in geometric measurements were analyzed as a diagnostic test for MAG3-defined pyeloplasty success using ROC curve analysis. In addition, six reviewers blinded to pyeloplasty success reviewed pre-operative and post-operative images visually for improved hydronephrosis and categorized pyeloplasty as success or failure based on simple visual review of RUS. Fifty-three repaired renal units were identified (50 children). There were five pyeloplasty failures, four of which underwent revision or nephrectomy. While all geometric measurements could discriminate pyeloplasty failure and success, the geometric measurements that discriminated best between pyeloplasty failure and success were change in collecting system roundness and change in RPCSR. Consensus opinion among six blinded reviewers using simple visual review had a sensitivity of 94% and PPV of 100% with respect to identifying pyeloplasty

  3. Validity of ultrasonography and measures of adult shoulder function and reliability of ultrasonography in detecting shoulder synovitis in patients with rheumatoid arthritis using magnetic resonance imaging as a gold standard.

    LENUS (Irish Health Repository)

    Bruyn, G A W

    2010-08-01

    To assess the intra- and interobserver reproducibility of musculoskeletal ultrasonography (US) in detecting inflammatory shoulder changes in patients with rheumatoid arthritis, and to determine the agreement between US and the Shoulder Pain and Disability Index (SPADI) and the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, using magnetic resonance imaging (MRI) as a gold standard.

  4. Standardization of heparins by means of high performance liquid chromatography equipped with a low angle laser light scattering detector

    NARCIS (Netherlands)

    Hennink, W.E.; van den Berg, J.W.A.; Feijen, Jan

    1987-01-01

    This study shows that HPLC-LALLS (high performance liquid chromatography with a light-scattering detector) is a convenient and reliable method for the characterization of standard heparin samples, provided that polyelectrolyte artefacts are suppressed by a suitable dialysis procedure. The method has

  5. Electrical equipment qualification

    International Nuclear Information System (INIS)

    Farmer, W.S.

    1983-01-01

    Electrical equipment qualification research programs being carried out by CEA, JAERI, and Sandia Laboratories are discussed. Objectives of the program are: (1) assessment of accident simulation methods for electrical equipment qualification testing; lower coarse (2) evaluation of equipment aging and accelerated aging methods; (3) determine radiation dose spectrum to electrical equipment and assess simulation methods for qualification; (4) identify inadequacies in electrical equipment qualification procedures and standards and potential failure modes; and (5) provide data for verifying and improving standards, rules and regulatory guides

  6. Usefulness of the Population Health Metrics Research Consortium gold standard verbal autopsy data for general verbal autopsy methods

    Science.gov (United States)

    2014-01-01

    Background Verbal Autopsy (VA) is widely viewed as the only immediate strategy for registering cause of death in much of Africa and Asia, where routine physician certification of deaths is not widely practiced. VA involves a lay interview with family or friends after a death, to record essential details of the circumstances. These data can then be processed automatically to arrive at standardized cause of death information. Methods The Population Health Metrics Research Consortium (PHMRC) undertook a study at six tertiary hospitals in low- and middle-income countries which documented over 12,000 deaths clinically and subsequently undertook VA interviews. This dataset, now in the public domain, was compared with the WHO 2012 VA standard and the InterVA-4 interpretative model. Results The PHMRC data covered 70% of the WHO 2012 VA input indicators, and categorized cause of death according to PHMRC definitions. After eliminating some problematic or incomplete records, 11,984 VAs were compared. Some of the PHMRC cause definitions, such as ‘preterm delivery’, differed substantially from the International Classification of Diseases, version 10 equivalent. There were some appreciable inconsistencies between the hospital and VA data, including 20% of the hospital maternal deaths being described as non-pregnant in the VA data. A high proportion of VA cases (66%) reported respiratory symptoms, but only 18% of assigned hospital causes were respiratory-related. Despite these issues, the concordance correlation coefficient between hospital and InterVA-4 cause of death categories was 0.61. Conclusions The PHMRC dataset is a valuable reference source for VA methods, but has to be interpreted with care. Inherently inconsistent cases should not be included when using these data to build other VA models. Conversely, models built from these data should be independently evaluated. It is important to distinguish between the internal and external validity of VA models. The effects of

  7. National Accreditation and Its Role in Early Education: An Analysis of Florida's Gold Seal Quality Child-Care Program and Licensing Standards

    Science.gov (United States)

    Winterbottom, Christian; Jones, Ithel

    2014-01-01

    This article reports on the first Florida statewide assessment of the Gold Seal Quality Care program, accreditation, and the relationship with licensing violations. This study analyzed the differences between the Department of Children and Families Gold Seal-Accredited facilities and nonaccredited facilities by comparing the facilities and the…

  8. Cryogenic equipment

    International Nuclear Information System (INIS)

    Leger, L.; Javellaud, J.; Caro, C.; Gilguy, R.; Testard, O.

    1966-06-01

    The cryostats presented here were built from standard parts; this makes it possible to construct a great variety of apparatus at minimum cost. The liquid nitrogen and helium reservoirs were designed so as to reduce losses to a minimum, and so as to make the cryostats as autonomous as possible. The experimental enclosure which is generally placed in the lower part of the apparatus requires a separate study in every case. Furthermore, complete assemblies such as transfer rods, isolated traps and high vacuum valves, were designed with a similar regard for the economic aspects and for the need for standardization. This equipment thus satisfies a great variety of experimental needs; it is readily adaptable and the consumptions of helium and liquid nitrogen are very low. (authors) [fr

  9. Dose values at the ovaries for sagittal irradiation equipment in X-ray pictures using a standard phantom

    International Nuclear Information System (INIS)

    Kragh, P.

    1977-07-01

    The dose values at the ovaries are calculated systematically with a phantom corresponding in its shape and composition to the human anatomy. In order to limit computer time for the photon transport calculations according to the Monte-Carlo-method the simplified method of calculation is used which was first stated by Rosenstein. The dose at the ovaries is listed in tables for the respective X-ray exposure in a.p. or p.a. direction at the standard film sizes. In addition, the exposure area product of the useful radiation and the distances of a reference point to the central beam and to the edge of the radiation field must be known. (orig.) [de

  10. National standards and code compliance for electrical equipment and instruments installed in hazardous locations for the cone penetrometer

    International Nuclear Information System (INIS)

    Bussell, J.H.

    1996-03-01

    The cone penetrometer is designed to measure the material properties of waste tank contents at the Hanford Site. The penetrometer system consists of a skid-mounted assembly, a penetrometer assembly (composed of a guide tube and a push rod), an active neutron moisture measurement probe, decontamination unit, and a support trailer containing a diesel-engine-driven hydraulic pump and a generator. The skid-mounted assembly is about 8 feet wide by 23 feet long and 15 feet high. Its nominal weight is about 40,000 pounds with the provisions to add up to 54,500 pounds of additional ballast. This document describes the cone penetrometer electrical instruments and how it complies with national standards

  11. Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard

    DEFF Research Database (Denmark)

    Ellegaard, K; Bliddal, H; Møller Døhn, U

    2014-01-01

    PURPOSE: To test the reliability and validity of a 3D US erosion score in RA using MRI as the gold standard. MATERIALS AND METHODS: RA patients were examined with 3D US and 3 T MRI over the 2nd and 3rd metacarpophalangeal joints. 3D blocks were evaluated by two investigators. The erosions were...... estimated according to a semi-quantitative score (SQS) (0 - 3) and a quantitative score (QS) (mm²). MRI was evaluated according to the RAMRIS score. For the estimation of reliability, intra-class correlation coefficients (ICC) were used. Validity was tested using Spearman's rho (rs). The sensitivity...... and specificity were also calculated. RESULTS: 28 patients with RA were included. The ICC for the inter-observer reliability in the QS was 0.41 and 0.13 for the metacarpal bone and phalangeal bone, respectively, and 0.86 and 0.16, respectively, in the SQS.  The ICC for the intra-observer reliability in the QS...

  12. Estimating prevalence and diagnostic test characteristics of bovine cysticercosis in Belgium in the absence of a 'gold standard' reference test using a Bayesian approach.

    Science.gov (United States)

    Jansen, Famke; Dorny, Pierre; Gabriël, Sarah; Eichenberger, Ramon Marc; Berkvens, Dirk

    2018-04-30

    A Bayesian model was developed to estimate values for the prevalence and diagnostic test characteristics of bovine cysticercosis (Taenia saginata) by combining results of four imperfect tests. Samples of 612 bovine carcases that were found negative for cysticercosis during routine meat inspection collected at three Belgian slaughterhouses, underwent enhanced meat inspection (additional incisions in the heart), dissection of the predilection sites, B158/B60 Ag-ELISA and ES Ab-ELISA. This Bayesian approach allows for the combination of prior expert opinion with experimental data to estimate the true prevalence of bovine cysticercosis in the absence of a gold standard test. A first model (based on a multinomial distribution and including all possible interactions between the individual tests) required estimation of 31 parameters, while only allowing for 15 parameters to be estimated. Including prior expert information about specificity and sensitivity resulted in an optimal model with a reduction of the number of parameters to be estimated to 8. The estimated bovine cysticercosis prevalence was 33.9% (95% credibility interval: 27.7-44.4%), while apparent prevalence based on meat inspection is only 0.23%. The test performances were estimated as follows (sensitivity (Se) - specificity (Sp)): enhanced meat inspection (Se 2.87% - Sp 100%), dissection of predilection sites (Se 69.8% - Sp 100%), Ag-ELISA (Se 26.9% - Sp 99.4%), Ab-ELISA (Se 13.8% - Sp 92.9%). Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Comparison of the novel Partec rapid malaria test to the conventional Giemsa stain and the gold standard real-time PCR.

    Science.gov (United States)

    Nkrumah, Bernard; Agyekum, Alex; Acquah, Samuel E K; May, Jürgen; Tannich, Egbert; Brattig, Norbert; Nguah, Samuel Blay; von Thien, Heidrun; Adu-Sarkodie, Yaw; Huenger, Frank

    2010-08-01

    Malaria remains the single most frequent cause of death in Africa, killing one child every 30 s, but treatment decisions are often made only on clinical diagnosis, as laboratory techniques to confirm the clinical suspicion are labor intensive and costly. In this study, we evaluated the recently developed Partec rapid malaria test (PM) for the detection of Plasmodium spp. in human blood from patients in an area where malaria is endemic and compared the results with those of thick blood film Giemsa stain (GS) in terms of its performance and operational characteristics, using real-time (RT) PCR as the gold standard. The sensitivities of the PM and the GS were 62.2% (95% CI, 56.3 to 67.8) and 61.8% (95% CI, 55.9 to 67.4), respectively, while the specificities were 96.0% (95% CI, 92.3 to 98.3) and 98% (95% CI, 95.0 to 99.5), respectively. There was an excellent agreement between the results for the PM and those of the GS (k [level of agreement] = 0.96; P < 0.001). The results for the PM were obtained more quickly and at less cost than those for the GS. The performance characteristics of the PM were almost equal to those of the GS, but the operational characteristics were better, and the PM can therefore be considered as an alternative method for GS.

  14. Comparison of the Novel Partec Rapid Malaria Test to the Conventional Giemsa Stain and the Gold Standard Real-Time PCR ▿

    Science.gov (United States)

    Nkrumah, Bernard; Agyekum, Alex; Acquah, Samuel E. K.; May, Jürgen; Tannich, Egbert; Brattig, Norbert; Nguah, Samuel Blay; von Thien, Heidrun; Adu-Sarkodie, Yaw; Huenger, Frank

    2010-01-01

    Malaria remains the single most frequent cause of death in Africa, killing one child every 30 s, but treatment decisions are often made only on clinical diagnosis, as laboratory techniques to confirm the clinical suspicion are labor intensive and costly. In this study, we evaluated the recently developed Partec rapid malaria test (PM) for the detection of Plasmodium spp. in human blood from patients in an area where malaria is endemic and compared the results with those of thick blood film Giemsa stain (GS) in terms of its performance and operational characteristics, using real-time (RT) PCR as the gold standard. The sensitivities of the PM and the GS were 62.2% (95% CI, 56.3 to 67.8) and 61.8% (95% CI, 55.9 to 67.4), respectively, while the specificities were 96.0% (95% CI, 92.3 to 98.3) and 98% (95% CI, 95.0 to 99.5), respectively. There was an excellent agreement between the results for the PM and those of the GS (k [level of agreement] = 0.96; P < 0.001). The results for the PM were obtained more quickly and at less cost than those for the GS. The performance characteristics of the PM were almost equal to those of the GS, but the operational characteristics were better, and the PM can therefore be considered as an alternative method for GS. PMID:20554822

  15. Correctness of multi-detector-row computed tomography for diagnosing mechanical prosthetic heart valve disorders using operative findings as a gold standard

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, I.Chen [Taichung Veterans General Hospital, Department of Radiology, Taichung (China); Institute of Clinical Medicine and Faculty of Medicine, National Yang-Ming University, Taipei (China); Lin, Yung-Kai; Chang, Yen; Wang, Chung-Chi; Hsieh, Shih-Rong; Wei, Hao-Ji; Tsai, Hung-Wen [Taichung Veterans General Hospital, Section of Cardiovascular Surgery, Cardiovascular Center, Taichung (China); Fu, Yun-Ching; Jan, Sheng-Ling [Institute of Clinical Medicine and Faculty of Medicine, National Yang-Ming University, Taipei (China); Taichung Veterans General Hospital, Section of Pediatric Cardiology, Department of Pediatrics, Taichung (China); Wang, Kuo-Yang [Taichung Veterans General Hospital, Section of General Cardiology, Cardiovascular Center, Taichung (China); Chung-Shan Medical University, Department of Medicine, Taichung (China); Chen, Min-Chi; Chen, Clayton Chi-Chang [Taichung Veterans General Hospital, Department of Radiology, Taichung (China); Central Taiwan University of Science and Technology, Department of Radiological Technology, Taichung (China)

    2009-04-15

    The purpose was to compare the findings of multi-detector computed tomography (MDCT) in prosthetic valve disorders using the operative findings as a gold standard. In a 3-year period, we prospectively enrolled 25 patients with 31 prosthetic heart valves. MDCT and transthoracic echocardiography (TTE) were done to evaluate pannus formation, prosthetic valve dysfunction, suture loosening (paravalvular leak) and pseudoaneurysm formation. Patients indicated for surgery received an operation within 1 week. The MDCT findings were compared with the operative findings. One patient with a Bjoerk-Shiley valve could not be evaluated by MDCT due to a severe beam-hardening artifact; thus, the exclusion rate for MDCT was 3.2% (1/31). Prosthetic valve disorders were suspected in 12 patients by either MDCT or TTE. Six patients received an operation that included three redo aortic valve replacements, two redo mitral replacements and one Amplatzer ductal occluder occlusion of a mitral paravalvular leak. The concordance of MDCT for diagnosing and localizing prosthetic valve disorders and the surgical findings was 100%. Except for images impaired by severe beam-hardening artifacts, MDCT provides excellent delineation of prosthetic valve disorders. (orig.)

  16. Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines.

    Science.gov (United States)

    Hooijmans, Carlijn R; de Vries, Rob; Leenaars, Marlies; Curfs, Jo; Ritskes-Hoitinga, Merel

    2011-03-01

    Several studies have demonstrated serious omissions in the way research that use animals is reported. In order to improve the quality of reporting of animal experiments, the Animals in research: reporting in vivo experiments (ARRIVE) Guidelines were published in the British Journal of Pharmacology in August 2010. However, not only the quality of reporting of completed animal studies needs to be improved, but also the design and execution of new experiments. With both these goals in mind, we published the Gold Standard Publication Checklist (GSPC) in May 2010, a few months before the ARRIVE guidelines appeared. In this letter, we compare the GSPC checklist with the ARRIVE Guidelines. The GSPC describes certain items in more detail, which makes it both easier to use when designing and conducting an experiment and particularly suitable for making systematic reviews of animal studies more feasible. In order to improve not only the reporting but also the planning, design, execution and thereby, the scientific quality of animal experiments, we strongly recommend to all scientists involved in animal experimentation and to editors of journals publishing animal studies to take a closer look at the contents of both the ARRIVE guidelines and GSPC, and select the set of guidelines which is most appropriate for their particular situation. © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

  17. Paraesophageal hernia repair in the emergency setting: is laparoscopy with the addition of a fundoplication the new gold standard?

    Science.gov (United States)

    Klinginsmith, Michael; Jolley, Jennifer; Lomelin, Daniel; Krause, Crystal; Heiden, Jace; Oleynikov, Dmitry

    2016-05-01

    Laparoscopic repair of paraesophageal hernia (PEH) with fundoplication is currently the preferred elective strategy, but emergent cases are often done open without an anti-reflux (AR) procedure. This study examined PEH repair in elective and urgent/emergent settings and investigated patient characteristic influence on the use of adjunctive techniques, such as AR procedures or gastrostomy tube (GT) placement. Utilizing the University HealthSystem Consortium Clinical Database Resource Manager, selected discharge data were retrieved using International Classification of Disease 9 diagnosis codes for PEH and procedure specific codes. Chi-squared and paired t tests were applied (α = 0.05). Discharge data from October 2010 through June 2014 indicated 7950 patients (≥18 years) underwent PEH surgery, 84.7 % were performed laparoscopically and 15.3 % open. 24.6 % of cases were classified urgent/emergent upon admission, and almost 70 % of these were completed laparoscopically. Open paraesophageal hernia repairs (OHR) represented a higher proportion of urgent/emergent cases but were only 30 % of this total. Laparoscopic paraesophageal hernia repair (LHR) patients were more likely to receive an AR procedure in all situations (54.9 % LHR vs. 26.3 % OHR). Almost 90 % of elective PEH repairs in this cohort were laparoscopic. Elective cases were more commonly associated with AR procedures than emergent cases which frequently incorporated GT placement. We demonstrate that laparoscopic PEH repair has become accepted in emergent cases. Open PEH repair is often reserved for emergent surgeries and less commonly includes an AR procedure. Laparoscopy with an AR procedure is clearly the standard of care in elective surgery. The decision to perform an open or laparoscopic surgery, with or without adjunctive techniques, may be based more on the physician's comfort with laparoscopic surgery and surgical practices than the patient's condition. Long-term follow-up studies are

  18. Bayesian spatio-temporal modeling of Schistosoma japonicum prevalence data in the absence of a diagnostic 'gold' standard.

    Directory of Open Access Journals (Sweden)

    Xian-Hong Wang

    Full Text Available BACKGROUND: Spatial modeling is increasingly utilized to elucidate relationships between demographic, environmental, and socioeconomic factors, and infectious disease prevalence data. However, there is a paucity of studies focusing on spatio-temporal modeling that take into account the uncertainty of diagnostic techniques. METHODOLOGY/PRINCIPAL FINDINGS: We obtained Schistosoma japonicum prevalence data, based on a standardized indirect hemagglutination assay (IHA, from annual reports from 114 schistosome-endemic villages in Dangtu County, southeastern part of the People's Republic of China, for the period 1995 to 2004. Environmental data were extracted from satellite images. Socioeconomic data were available from village registries. We used Bayesian spatio-temporal models, accounting for the sensitivity and specificity of the IHA test via an equation derived from the law of total probability, to relate the observed with the 'true' prevalence. The risk of S. japonicum was positively associated with the mean land surface temperature, and negatively correlated with the mean normalized difference vegetation index and distance to the nearest water body. There was no significant association between S. japonicum and socioeconomic status of the villages surveyed. The spatial correlation structures of the observed S. japonicum seroprevalence and the estimated infection prevalence differed from one year to another. Variance estimates based on a model adjusted for the diagnostic error were larger than unadjusted models. The generated prediction map for 2005 showed that most of the former and current infections occur in close proximity to the Yangtze River. CONCLUSION/SIGNIFICANCE: Bayesian spatial-temporal modeling incorporating diagnostic uncertainty is a suitable approach for risk mapping S. japonicum prevalence data. The Yangtze River and its tributaries govern schistosomiasis transmission in Dangtu County, but spatial correlation needs to be taken

  19. Bayesian spatio-temporal modeling of Schistosoma japonicum prevalence data in the absence of a diagnostic 'gold' standard.

    Science.gov (United States)

    Wang, Xian-Hong; Zhou, Xiao-Nong; Vounatsou, Penelope; Chen, Zhao; Utzinger, Jürg; Yang, Kun; Steinmann, Peter; Wu, Xiao-Hua

    2008-06-11

    Spatial modeling is increasingly utilized to elucidate relationships between demographic, environmental, and socioeconomic factors, and infectious disease prevalence data. However, there is a paucity of studies focusing on spatio-temporal modeling that take into account the uncertainty of diagnostic techniques. We obtained Schistosoma japonicum prevalence data, based on a standardized indirect hemagglutination assay (IHA), from annual reports from 114 schistosome-endemic villages in Dangtu County, southeastern part of the People's Republic of China, for the period 1995 to 2004. Environmental data were extracted from satellite images. Socioeconomic data were available from village registries. We used Bayesian spatio-temporal models, accounting for the sensitivity and specificity of the IHA test via an equation derived from the law of total probability, to relate the observed with the 'true' prevalence. The risk of S. japonicum was positively associated with the mean land surface temperature, and negatively correlated with the mean normalized difference vegetation index and distance to the nearest water body. There was no significant association between S. japonicum and socioeconomic status of the villages surveyed. The spatial correlation structures of the observed S. japonicum seroprevalence and the estimated infection prevalence differed from one year to another. Variance estimates based on a model adjusted for the diagnostic error were larger than unadjusted models. The generated prediction map for 2005 showed that most of the former and current infections occur in close proximity to the Yangtze River. Bayesian spatial-temporal modeling incorporating diagnostic uncertainty is a suitable approach for risk mapping S. japonicum prevalence data. The Yangtze River and its tributaries govern schistosomiasis transmission in Dangtu County, but spatial correlation needs to be taken into consideration when making risk prediction at small scales.

  20. Comparison of the gold standard of hemoglobin measurement with the clinical standard (BGA) and noninvasive hemoglobin measurement (SpHb) in small children: a prospective diagnostic observational study.

    Science.gov (United States)

    Wittenmeier, Eva; Bellosevich, Sophia; Mauff, Susanne; Schmidtmann, Irene; Eli, Michael; Pestel, Gunther; Noppens, Ruediger R

    2015-10-01

    Collecting a blood sample is usually necessary to measure hemoglobin levels in children. Especially in small children, noninvasively measuring the hemoglobin level could be extraordinarily helpful, but its precision and accuracy in the clinical environment remain unclear. In this study, noninvasive hemoglobin measurement and blood gas analysis were compared to hemoglobin measurement in a clinical laboratory. In 60 healthy preoperative children (0.2-7.6 years old), hemoglobin was measured using a noninvasive method (SpHb; Radical-7 Pulse Co-Oximeter), a blood gas analyzer (clinical standard, BGAHb; ABL 800 Flex), and a laboratory hematology analyzer (reference method, labHb; Siemens Advia). Agreement between the results was assessed by Bland-Altman analysis and by determining the percentage of outliers. Sixty SpHb measurements, 60 labHb measurements, and 59 BGAHb measurements were evaluated. In 38% of the children, the location of the SpHb sensor had to be changed more than twice for the signal quality to be sufficient. The bias/limits of agreement between SpHb and labHb were -0.65/-3.4 to 2.1 g·dl(-1) . Forty-four percent of the SpHb values differed from the reference value by more than 1 g·dl(-1) . Age, difficulty of measurement, and the perfusion index (PI) had no influence on the accuracy of SpHb. The bias/limits of agreement between BGAHb and labHb were 1.14/-1.6 to 3.9 g·dl(-1) . Furthermore, 66% of the BGAHb values differed from the reference values by more than 1 g·dl(-1) . The absolute mean difference between SpHb and labHb (1.1 g·dl(-1) ) was smaller than the absolute mean difference between BGAHb and labHb (1.5 g·dl(-1) /P = 0.024). Noninvasive measurement of hemoglobin agrees more with the reference method than the measurement of hemoglobin using a blood gas analyzer. However, both methods can show clinically relevant differences from the reference method (ClinicalTrials.gov: NCT01693016). © 2015 John Wiley & Sons Ltd.

  1. 1998 Annual Study Report. Standardization of image processing for digital home equipment; 1998 nendo seika hokokusho. Kateiyo digital denshi kiki ni okeru digital gazo shori no hyojunka

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The electronic industry should invariably correspond to MPEG-4, when considering the essential conditions for home information equipment of the next generation to be used massively. This project is aimed at formulation of the standard platform for MPEG-4, and identification of the necessary examples and corresponding the necessary tools/functions thereto, to give an impetus for the future development, and to positively provide the additional aids to the tools which strengthen MPEG-4 in the arena of promoting the international standardization. The efforts in this year began with investigations on the assumption of the concrete application examples, considered from the standards' structures, and were concentrated on investigations on characteristic problems involved in each of the system, server and client blocks which constitute the system, and then on identification of the products application, based on the analysis of the MPEG-4 profiles and levels. These have led to selection of an MPEG-4 receiver as the case study item for extracting problems possibly involved in assembling works. (NEDO)

  2. Gold and Silver Extraction from Leach Solutions

    OpenAIRE

    Bagdaulet K. Kenzhaliyev; Renata R. Iskhakova; Zamzagul D. Dosymbaeva; Esen N. Sulejmenov

    2014-01-01

    There has been carried out an investigation on the extraction of gold and silver from thiosulfate solutions: standard test and technological solutions of chemical and electrochemical leaching. The influence of related metals on the process of extracting gold from solution was studied. There has been conducted a comparative study of the IR spectra of solutions after the sorption of gold, silver and related metals.

  3. 'Outbreak Gold Standard' selection to provide optimized threshold for infectious diseases early-alert based on China Infectious Disease Automated-alert and Response System.

    Science.gov (United States)

    Wang, Rui-Ping; Jiang, Yong-Gen; Zhao, Gen-Ming; Guo, Xiao-Qin; Michael, Engelgau

    2017-12-01

    The China Infectious Disease Automated-alert and Response System (CIDARS) was successfully implemented and became operational nationwide in 2008. The CIDARS plays an important role in and has been integrated into the routine outbreak monitoring efforts of the Center for Disease Control (CDC) at all levels in China. In the CIDARS, thresholds are determined using the "Mean+2SD‟ in the early stage which have limitations. This study compared the performance of optimized thresholds defined using the "Mean +2SD‟ method to the performance of 5 novel algorithms to select optimal "Outbreak Gold Standard (OGS)‟ and corresponding thresholds for outbreak detection. Data for infectious disease were organized by calendar week and year. The "Mean+2SD‟, C1, C2, moving average (MA), seasonal model (SM), and cumulative sum (CUSUM) algorithms were applied. Outbreak signals for the predicted value (Px) were calculated using a percentile-based moving window. When the outbreak signals generated by an algorithm were in line with a Px generated outbreak signal for each week, this Px was then defined as the optimized threshold for that algorithm. In this study, six infectious diseases were selected and classified into TYPE A (chickenpox and mumps), TYPE B (influenza and rubella) and TYPE C [hand foot and mouth disease (HFMD) and scarlet fever]. Optimized thresholds for chickenpox (P 55 ), mumps (P 50 ), influenza (P 40 , P 55 , and P 75 ), rubella (P 45 and P 75 ), HFMD (P 65 and P 70 ), and scarlet fever (P 75 and P 80 ) were identified. The C1, C2, CUSUM, SM, and MA algorithms were appropriate for TYPE A. All 6 algorithms were appropriate for TYPE B. C1 and CUSUM algorithms were appropriate for TYPE C. It is critical to incorporate more flexible algorithms as OGS into the CIDRAS and to identify the proper OGS and corresponding recommended optimized threshold by different infectious disease types.

  4. Multicenter study on costs associated with two surgical procedures: GreenLight XPS 180 W versus the gold standard transurethral resection of the prostate.

    Science.gov (United States)

    Benejam-Gual, J M; Sanz-Granda, A; Budía, A; Extramiana, J; Capitán, C

    2014-01-01

    To analyze the costs associated with two surgical procedures for lower urinary tract symptoms secondary to benign prostatic hyperplasia: GreenLight XPS 180¦W versus the gold standard transurethral resection of the prostate. A multicenter, retrospective cost study was carried out from the National Health Service perspective, over a 3-month time period. Costs were broken down into pre-surgical, surgical and post-surgical phases. Data were extracted from records of patients operated sequentially, with IPSS=15, Qmax=15 mL/seg and a prostate volume of 40-80mL, adding only direct healthcare costs (€, 2013) associated with the procedure and management of complications. A total of 79 patients sequentially underwent GL XPS (n: 39) or TURP (n: 40) between July and October, 2013. Clinical outcomes were similar (94.9% and 92.5%, GL XPS and TURP, respectively) without significant differences (P=.67). The average direct cost per patient was reduced by €114 in GL XPS versus TURP patients; the cost was higher in the surgical phase with GL XPS (difference: €1,209; P<.001) but was lower in the post-surgical phase (difference: €-1,351; P<.001). The GreenLight XPS 180-W laser system is associated with a reduction in costs with respect to transurethral resection of prostate in the surgical treatment of LUTS secondary to PBH. This reduction is due to a shorter inpatient length of stay that offsets the cost of the new technology. Copyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.

  5. Stealth lipid polymer hybrid nanoparticles loaded with rutin for effective brain delivery - comparative study with the gold standard (Tween 80): optimization, characterization and biodistribution.

    Science.gov (United States)

    Ishak, Rania A H; Mostafa, Nada M; Kamel, Amany O

    2017-11-01

    The blood-brain barrier is considered the leading physiological obstacle hindering the transport of neurotherapeutics to brain cells. The application of nanotechnology coupled with surfactant coating is one of the efficacious tactics overcoming this barrier. The aim of this study was to develop lipid polymer hybrid nanoparticles (LPHNPs), composed of a polymeric core and a phospholipid shell entangled, for the first time, with PEG-based surfactants (SAA) viz. TPGS or Solutol HS 15 in comparison with the gold standard Tween 80, aiming to enhance brain delivery and escape opsonization. LPHNPs were successfully prepared using modified single-step nanoprecipitation technique, loaded with the flavonoid rutin (RU), extracted from the flowers of Calendula officinalis L., and recently proved as a promising anti-Alzheimer. The effect of the critical process parameters (CPP) viz. PLGA amount, W lecithin /W PLGA ratio, and Tween 80 concentration on critical quality attributes (CQA); entrapment, size and size distribution, was statistically analyzed via design of experiments, and optimized using the desirability function. The optimized CPP were maintained while substituting Tween 80 with other PEG-SAA. All hybrid particles exhibited spherical shape with perceptible lipid shells. The biocompatibility of the prepared NPs was confirmed by hemolysis test. The pharmacokinetic assessments, post-intravenous administration to rats, revealed a significant higher RU bioavailability for NPs relative to drug solution. Biodistribution studies proved non-significant differences in RU accumulation within brain, but altered phagocytic uptake among various LPHNPs. The present study endorses the successful development of LPHNPs using PEG-SAA, and confirms the prospective applicability of TPGS and Solutol in enhancing brain delivery.

  6. Molecular testing for viral and bacterial enteric pathogens: gold standard for viruses, but don't let culture go just yet?

    Science.gov (United States)

    Bloomfield, Maxim G; Balm, Michelle N D; Blackmore, Timothy K

    2015-04-01

    Contemporary diagnostic microbiology is increasingly adopting molecular methods as front line tests for a variety of samples. This trend holds true for detection of enteric pathogens (EP), where nucleic acid amplification tests (NAAT) for viruses are well established as the gold standard, and an increasing number of commercial multi-target assays are now available for bacteria and parasites. NAAT have significant sensitivity and turnaround time advantages over traditional methods, potentially returning same-day results. Multiplex panels offer an attractive 'one-stop shop' that may provide workflow and cost advantages to laboratories processing large sample volumes. However, there are a number of issues which need consideration. Reflex culture is required for antibiotic susceptibility testing and strain typing when needed for food safety and other epidemiological investigations. Surveillance systems will need to allow for differences in disease incidence due to the enhanced sensitivity of NAAT. Laboratories should be mindful of local epidemiology when selecting which pathogens to include in multiplex panels, and be thoughtful regarding which pathogens will not be detected. Multiplex panels may not be appropriate in certain situations, such as hospital-onset diarrhoea, where Clostridium difficile testing might be all that is required, and laboratories may wish to retain the flexibility to run single tests in such situations. The clinical impact of rapid results is also likely to be relatively minor, as infective diarrhoea is a self-limiting illness in the majority of cases. Laboratories will require strategies to assist users in the interpretation of the results produced by NAAT, particularly where pathogens are detected at low levels with uncertain clinical significance. These caveats aside, faecal NAAT are increasingly being used and introduce a new era of diagnosis of gastrointestinal infection.

  7. Combining Shigella Tn-seq data with gold-standard E. coli gene deletion data suggests rare transitions between essential and non-essential gene functionality.

    Science.gov (United States)

    Freed, Nikki E; Bumann, Dirk; Silander, Olin K

    2016-09-06

    Gene essentiality - whether or not a gene is necessary for cell growth - is a fundamental component of gene function. It is not well established how quickly gene essentiality can change, as few studies have compared empirical measures of essentiality between closely related organisms. Here we present the results of a Tn-seq experiment designed to detect essential protein coding genes in the bacterial pathogen Shigella flexneri 2a 2457T on a genome-wide scale. Superficial analysis of this data suggested that 481 protein-coding genes in this Shigella strain are critical for robust cellular growth on rich media. Comparison of this set of genes with a gold-standard data set of essential genes in the closely related Escherichia coli K12 BW25113 revealed that an excessive number of genes appeared essential in Shigella but non-essential in E. coli. Importantly, and in converse to this comparison, we found no genes that were essential in E. coli and non-essential in Shigella, implying that many genes were artefactually inferred as essential in Shigella. Controlling for such artefacts resulted in a much smaller set of discrepant genes. Among these, we identified three sets of functionally related genes, two of which have previously been implicated as critical for Shigella growth, but which are dispensable for E. coli growth. The data presented here highlight the small number of protein coding genes for which we have strong evidence that their essentiality status differs between the closely related bacterial taxa E. coli and Shigella. A set of genes involved in acetate utilization provides a canonical example. These results leave open the possibility of developing strain-specific antibiotic treatments targeting such differentially essential genes, but suggest that such opportunities may be rare in closely related bacteria.

  8. Stress-only myocardial perfusion scintigraphy: a prospective study on the accuracy and observer agreement with quantitative coronary angiography as the gold standard.

    Science.gov (United States)

    Ejlersen, June A; May, Ole; Mortensen, Jesper; Nielsen, Gitte L; Lauridsen, Jeppe F; Allan, Johansen

    2017-11-01

    Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. A total of 109 patients with typical angina and no previous coronary artery disease underwent a 2-day stress (exercise)/rest, gated, and attenuation-corrected (AC), 99m-technetium-sestamibi perfusion study, followed by invasive coronary angiography. The stress datasets were evaluated twice by four physicians with two different training levels (expert and novice): familiar and unfamiliar with AC. The two experts also made a consensus reading of the integrated stress-rest datasets. The consensus reading and quantitative data from the invasive coronary angiography were applied as reference methods. The sensitivity/specificity were 0.92-1.00/0.73-0.90 (reference: expert consensus reading), 0.93-0.96/0.63-0.82 (reference: ≥1 stenosis>70%), and 0.75-0.88/0.70-0.88 (reference: ≥1 stenosis>50%). The four readers showed a high and fairly equal sensitivity independent of their familiarity with AC. The expert familiar with AC had the highest specificity independent of the reference method. The intraobserver and interobserver agreements on the stress-only readings were good (readers without AC experience) to excellent (readers with AC experience). AC stress-only images yielded a high sensitivity independent of the training level and experience with AC of the nuclear physician, whereas the specificity correlated positively with both. Interobserver and intraobserver agreements tended to be the best for physicians with AC experience.

  9. The standardization methods of radioactive sources (125I, 131I, 99mTc, and 18F) for calibrating nuclear medicine equipment in Indonesia

    International Nuclear Information System (INIS)

    Wurdiyanto, G; Candra, H

    2016-01-01

    The standardization of radioactive sources ( 125 I, 131 I, 99m Tc and 18 F) to calibrate the nuclear medicine equipment had been carried out in PTKMR-BATAN. This is necessary because the radioactive sources used in the field of nuclear medicine has a very short half-life in other that to obtain a quality measurement results require special treatment. Besides that, the use of nuclear medicine techniques in Indonesia develop rapidly. All the radioactive sources were prepared by gravimetric methods. Standardization of 125 I has been carried out by photon- photon coincidence methods, while the others have been carried out by gamma spectrometry methods. The standar sources are used to calibrate a Capintec CRC-7BT radionuclide calibrator. The results shows that calibration factor for Capintec CRC-7BT dose calibrator is 1,03; 1,02; 1,06; and 1,04 for 125 I, 131 I, 99m Tc and 18 F respectively, by about 5 to 6% of the expanded uncertainties. (paper)

  10. The standardization methods of radioactive sources (125I, 131I, 99mTc, and 18F) for calibrating nuclear medicine equipment in Indonesia

    Science.gov (United States)

    Wurdiyanto, G.; Candra, H.

    2016-03-01

    The standardization of radioactive sources (125I, 131I, 99mTc and 18F) to calibrate the nuclear medicine equipment had been carried out in PTKMR-BATAN. This is necessary because the radioactive sources used in the field of nuclear medicine has a very short half-life in other that to obtain a quality measurement results require special treatment. Besides that, the use of nuclear medicine techniques in Indonesia develop rapidly. All the radioactive sources were prepared by gravimetric methods. Standardization of 125I has been carried out by photon- photon coincidence methods, while the others have been carried out by gamma spectrometry methods. The standar sources are used to calibrate a Capintec CRC-7BT radionuclide calibrator. The results shows that calibration factor for Capintec CRC-7BT dose calibrator is 1,03; 1,02; 1,06; and 1,04 for 125I, 131I, 99mTc and 18F respectively, by about 5 to 6% of the expanded uncertainties.

  11. Space Heating Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, Kevin D.

    1998-01-01

    The performance evaluation of space heating equipment for a geothermal application is generally considered from either of two perspectives: (a) selecting equipment for installation in new construction, or (b) evaluating the performance and retrofit requirements of an existing system. With regard to new construction, the procedure is relatively straightforward. Once the heating requirements are determined, the process need only involve the selection of appropriately sized hot water heating equipment based on the available water temperature. It is important to remember that space heating equipment for geothermal applications is the same equipment used in non-geothermal applications. What makes geothermal applications unique is that the equipment is generally applied at temperatures and flow rates that depart significantly from traditional heating system design. This chapter presents general considerations for the performance of heating equipment at non-standard temperature and flow conditions, retrofit of existing systems, and aspects of domestic hot water heating.

  12. 1968 Listing of Swimming Pool Equipment.

    Science.gov (United States)

    National Sanitation Foundation, Ann Arbor, MI. Testing Lab.

    An up-to-date listing of swimming pool equipment including--(1) companies authorized to display the National Sanitation Foundation seal of approval, (2) equipment listed as meeting NSF swimming pool equipment standards relating to diatomite type filters, (3) equipment listed as meeting NSF swimming pool equipment standard relating to sand type…

  13. Exploration and Application of Standardization Management of Electrical Equipment Maintenance in Chemical Enterprises%化工企业电气设备检修标准化管理探索及应用

    Institute of Scientific and Technical Information of China (English)

    陶者青

    2016-01-01

    Discusses the current large-scale chemical enterprise electrical equipment maintenance problems,and the company electrical equipment maintenance standardization of the practice of the introduction and summary.%探讨目前大型化工企业电气设备检修存在问题,并对该公司电气设备检修标准化的实践,进行了介绍与总结。

  14. HVAC systems and equipment

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, S.T. (Linford Air and Refrigeration Company, Oakland, CA (US))

    1990-02-01

    The author discusses the section of the ASHRAE Standard 90.1-1989 which addresses HVAC systems and equipment. New features of HVAC systems mandatory general requirements are described. New prescriptive requirements are detailed.

  15. No gold standard estimation of the sensitivity and specificity of two molecular diagnostic protocols for Trypanosoma brucei spp. in Western Kenya.

    Directory of Open Access Journals (Sweden)

    Barend Mark de Clare Bronsvoort

    2010-01-01

    Full Text Available African animal trypanosomiasis is caused by a range of tsetse transmitted protozoan parasites includingTrypanosoma vivax, Trypanosoma congolense and Trypansoma brucei. In Western Kenya and other parts of East Africa two subspecies of T. brucei, T.b. brucei and the zoonoticT.b. rhodesiense, co-circulate in livestock. A range of polymerase chain reactions (PCR have been developed as important molecular diagnostic tools for epidemiological investigations of T. brucei s.l. in the animal reservoir and of its zoonotic potential. Quantification of the relative performance of different diagnostic PCRs is essential to ensure comparability of studies. This paper describes an evaluation of two diagnostic test systems for T. brucei using a T. brucei s.l. specific PCR [1] and a single nested PCR targeting the Internal Transcribed Spacer (ITS regions of trypanosome ribosomal DNA [2]. A Bayesian formulation of the Hui-Walter latent class model was employed to estimate their test performance in the absence of a gold standard test for detecting T.brucei s.l. infections in ear-vein blood samples from cattle, pig, sheep and goat populations in Western Kenya, stored on Whatman FTA cards. The results indicate that the system employing the T. brucei s.l. specific PCR (Se1=0.760 had a higher sensitivity than the ITS-PCR (Se2=0.640; both have high specificity (Sp1=0.998; Sp2=0.997. The true prevalences for livestock populations were estimated (pcattle=0.091, ppigs=0.066, pgoats=0.005, psheep=0.006, taking into account the uncertainties in the specificity and sensitivity of the two test systems. Implications of test performance include the required survey sample size; due to its higher sensitivity and specificity, the T. brucei s.l. specific PCR requires a consistently smaller sample size than the ITS-PCR for the detection of T. brucei s.l. However the ITS-PCR is able to simultaneously screen samples for other pathogenic trypanosomes and may thus be, overall, a better

  16. Equipment considerations

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Trace or ultratrace analyses require that the HPLC equipment used, including the detector, be optimal for such determinations. HPLC detectors are discussed at length in Chapter 4; discussion here is limited to the rest of the equipment. In general, commercial equipment is adequate for trace analysis; however, as the authors approach ultratrace analysis, it becomes very important to examine the equipment thoroughly and optimize it, where possible. For this reason they will review the equipment commonly used in HPLC and discuss the optimization steps. Detectability in HPLC is influenced by two factors (1): (a) baseline noise or other interferences that lead to errors in assigning the baseline absorbance; (b) peak width. 87 refs

  17. Gold Museum

    OpenAIRE

    Efraín Sánchez Cabra

    2003-01-01

    On 22 december 1939, the Banco de la República, the Central Bank of Colombia, purchased a 23.5 centimetres high pre-Columbian gold arte fact weighing 777·7 grams that was to become the Gold M useum's foundation stone. Described as a Quimbaya poporo, it is a masterpiece of pre-Hispanic goldwork, an object of beauty whose brightly burnished body and neck, crowned with four sphere-like or naments, rest on an exquisite cast metal tiligree base and which seems to ftoat in a space of its own. The b...

  18. Green Gold

    International Nuclear Information System (INIS)

    Salamandra Martinez, Carlos

    2004-01-01

    The main purpose of this work is to offer a general panoramic of the processes or experiences pilot that are carried out in the Project Green Gold, as strategy of environmental sustainability and organizational invigoration in Choco, especially in the 12 communities of the municipalities of Tado and Condoto. It is also sought to offer a minimum of information on the techniques of handmade production and to show the possibilities to carry out in a rational way the use and use of the natural resources. The Project Green Gold is carried out by the Corporation Green Gold (COV) and co-financed with resources of international and national character, the intervention of the financial resources it achievement mainly for the use of clean processes in the extraction stages and metals benefit. The project is centered primarily in the absence of use of products or toxic substances as the mercury, fair trade, organizational invigoration, execution of 11 approaches and certification of the metals Gold and Platinum. The COV, it has come executing the proposal from the year 2001 with the premise of contributing to the balance between the rational exploitation of the natural resources and the conservation of the environment in the Choco. In the project they are used technical handmade characteristic of the region framed inside the mining activity and production activities are diversified in the productive family units. Those producing with the support of entities of juridical character, specify the necessary game rules for the extraction and products commercialization

  19. IEEE No. 323, IEEE trial-use standard: General guide for qualifying Class I electric equipment for nuclear power generating stations

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This document describes the basic requirements for the qualification of Class I electric equipment. This is equipment which is essential to the safe shutdown and isolation of the reactor or whose failure or damage could result in significant release of radioactive material. The purpose of this document is to provide guidance for demonstrating the qualifications of electrical equipment as required in the IEEE Std 279 -- Criteria for Nuclear Power Generating Station Protection Systems, and IEEE Std 308 -- Criteria for Class 1E Electric Systems for Nuclear Power Generating Stations. The qualification methods described may be used in conjunction with the Guides for qualifying specific types of equipment, (see Foreword), for updating qualification following modifications or for qualifying equipment for which no applicable Guide exists

  20. Phonon assisted thermophoretic motion of gold nanoparticles inside carbon nanotubes

    DEFF Research Database (Denmark)

    Schoen, Philipp A.E.; Walther, Jens Honore; Poulikakos, Dimos

    2007-01-01

    The authors investigate the thermally driven mass transport of gold nanoparticles confined inside carbon nanotubes using molecular dynamics simulations. The observed thermophoretic motion of the gold nanoparticles correlates with the phonon dispersion exhibited by a standard carbon nanotube and...

  1. Determination of gold in gold ores

    International Nuclear Information System (INIS)

    Keedy, C.R.; Parson, L.; Shen, J.

    1989-01-01

    The gold content of placer gold flakes and gold bearing ores was determined by instrumental and radiochemical neutron activation analysis, respectively. It was discovered that significant errors result in the instrumental method for gold flakes as small as 10 mg due to sample self-absorption of neutrons during irradiation. Reliable results were obtained for both ore samples and gold flakes by dissolving the samples in aqua regia prior to irradiation. (author) 7 refs.; 3 tabs

  2. Gold and Silver Extraction from Leach Solutions

    Directory of Open Access Journals (Sweden)

    Bagdaulet K. Kenzhaliyev

    2014-03-01

    Full Text Available There has been carried out an investigation on the extraction of gold and silver from thiosulfate solutions: standard test and technological solutions of chemical and electrochemical leaching. The influence of related metals on the process of extracting gold from solution was studied. There has been conducted a comparative study of the IR spectra of solutions after the sorption of gold, silver and related metals.

  3. Consent for routine neonatal procedures: A study of practices in Irish neonatal units. How do we compare with the gold standard BAPM guidelines?

    LENUS (Irish Health Repository)

    Ryan, M A

    2017-06-01

    The Irish National Consent Policy (NCP)¹ proposes that the legal requirement for consent extends to all forms of interventions, investigations and treatment, carried out on or behalf of the Health Service Executive (HSE). This study employs a quantitative descriptive approach to investigate the practices for obtaining consent for an identified group of routine neonatal procedures in neonatal facilities throughout Ireland. The BAPM (British Association of Perinatal Medicine)² guidelines were identified as ‘gold standard’ for the purposes of this study. The results indicated a lack of consistency between participating units pertaining to the modes of consent utilised and notable variances from ‘gold standard’ guidelines. Unanimity was evident for 3 procedures only (administering BCG, 6-in-1, and donor breast milk to infant). Significant findings related to EEG with video recordings, MRI\\/CT and gastro intestinal imaging, screening of an infant with suspected substance abuse or retinopathy of prematurity screening (ROP), administration of Vitamin K, and the carrying out of a lumbar puncture.

  4. Technical support document: Energy efficiency standards for consumer products: Room air conditioners, water heaters, direct heating equipment, mobile home furnaces, kitchen ranges and ovens, pool heaters, fluorescent lamp ballasts and television sets. Volume 1, Methodology

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    The Energy Policy and Conservation Act (P.L. 94-163), as amended, establishes energy conservation standards for 12 of the 13 types of consumer products specifically covered by the Act. The legislation requires the Department of Energy (DOE) to consider new or amended standards for these and other types of products at specified times. DOE is currently considering amending standards for seven types of products: water heaters, direct heating equipment, mobile home furnaces, pool heaters, room air conditioners, kitchen ranges and ovens (including microwave ovens), and fluorescent light ballasts and is considering establishing standards for television sets. This Technical Support Document presents the methodology, data, and results from the analysis of the energy and economic impacts of the proposed standards. This volume presents a general description of the analytic approach, including the structure of the major models.

  5. Nondestructive analysis of the gold quarter liras

    International Nuclear Information System (INIS)

    Cakir, C.; Guerol, A.; Demir, L.; Sahin, Y.

    2009-01-01

    In this study, we have prepared seven Au-Cu standards in the concentration range of 18-24 (as carat) for nondestructive control of gold quarter liras. Some calibration curves for quantitative analysis of Au in the gold quarter liras that commercially present in Turkey have been plotted using these standard samples. The characteristic X-rays of Au and Cu emitted from these standard samples and the test sample with known composition are recorded by using a Ge(Li) detector. These calibration curves provide a nondestructive analysis of gold quarter liras with the uncertainties about 1.18%. (author)

  6. Review of Real-Time 3-Dimensional Image Guided Radiation Therapy on Standard-Equipped Cancer Radiation Therapy Systems: Are We at the Tipping Point for the Era of Real-Time Radiation Therapy?

    Science.gov (United States)

    Keall, Paul J; Nguyen, Doan Trang; O'Brien, Ricky; Zhang, Pengpeng; Happersett, Laura; Bertholet, Jenny; Poulsen, Per R

    2018-04-14

    To review real-time 3-dimensional (3D) image guided radiation therapy (IGRT) on standard-equipped cancer radiation therapy systems, focusing on clinically implemented solutions. Three groups in 3 continents have clinically implemented novel real-time 3D IGRT solutions on standard-equipped linear accelerators. These technologies encompass kilovoltage, combined megavoltage-kilovoltage, and combined kilovoltage-optical imaging. The cancer sites treated span pelvic and abdominal tumors for which respiratory motion is present. For each method the 3D-measured motion during treatment is reported. After treatment, dose reconstruction was used to assess the treatment quality in the presence of motion with and without real-time 3D IGRT. The geometric accuracy was quantified through phantom experiments. A literature search was conducted to identify additional real-time 3D IGRT methods that could be clinically implemented in the near future. The real-time 3D IGRT methods were successfully clinically implemented and have been used to treat more than 200 patients. Systematic target position shifts were observed using all 3 methods. Dose reconstruction demonstrated that the delivered dose is closer to the planned dose with real-time 3D IGRT than without real-time 3D IGRT. In addition, compromised target dose coverage and variable normal tissue doses were found without real-time 3D IGRT. The geometric accuracy results with real-time 3D IGRT had a mean error of real-time 3D IGRT methods using standard-equipped radiation therapy systems that could also be clinically implemented. Multiple clinical implementations of real-time 3D IGRT on standard-equipped cancer radiation therapy systems have been demonstrated. Many more approaches that could be implemented were identified. These solutions provide a pathway for the broader adoption of methods to make radiation therapy more accurate, impacting tumor and normal tissue dose, margins, and ultimately patient outcomes. Copyright © 2018

  7. Absolute measurement of a standard thermal-neutron flux using gold-detector activation; Mesure absolue d'un flux etalon de neutrons thermiques par activation de detecteurs d'or

    Energy Technology Data Exchange (ETDEWEB)

    Paternot, Y [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-02-15

    The density of neutrons in a standard stacking is determined between the zero-energy and the cut-off energy of 1 mm thick cadmium unit using a gold detector. Its absolute activity is measured using a 4 {pi} {beta} counter calibrated for 4 {pi} {beta},{gamma} coincidence by counting strongly active sources. The correction factor F due to the disintegration process for the gold is determined experimentally. {phi}{sub 0} = N{sub 0} {sup E}Cd{sub V0} = 6495 {+-} 1.5 per cent n/cm{sup 2}/s. (author) [French] La densite de neutrons dans un empilement etalon est determinee entre l'energie zero et l'energie de coupure d'un boitier de cadmium de 1 mm d'epaisseur au moyen d'un detecteur d'or. Son activite absolue est mesuree a l'aide d'un compteur 4 {pi} {beta} etalonne en coincidence 4 {pi} {beta},{gamma} par comptage de sources fortement actives. Le facteur de correction F d au schema de desintegration de l'or est determine experimentalement. {phi}{sub 0} = N{sub 0} {sup E}Cd{sub V0} = 6495 {+-} 1.5 pour cent n/cm{sup 2}/s. (auteur)

  8. Real-time cardiac magnetic resonance cine imaging with sparse sampling and iterative reconstruction for left-ventricular measures: Comparison with gold-standard segmented steady-state free precession.

    Science.gov (United States)

    Camargo, Gabriel C; Erthal, Fernanda; Sabioni, Leticia; Penna, Filipe; Strecker, Ralph; Schmidt, Michaela; Zenge, Michael O; Lima, Ronaldo de S L; Gottlieb, Ilan

    2017-05-01

    Segmented cine imaging with a steady-state free-precession sequence (Cine-SSFP) is currently the gold standard technique for measuring ventricular volumes and mass, but due to multi breath-hold (BH) requirements, it is prone to misalignment of consecutive slices, time consuming and dependent on respiratory capacity. Real-time cine avoids those limitations, but poor spatial and temporal resolution of conventional sequences has prevented its routine application. We sought to examine the accuracy and feasibility of a newly developed real-time sequence with aggressive under-sampling of k-space using sparse sampling and iterative reconstruction (Cine-RT). Stacks of short-axis cines were acquired covering both ventricles in a 1.5T system using gold standard Cine-SSFP and Cine-RT. Acquisition parameters for Cine-SSFP were: acquisition matrix of 224×196, temporal resolution of 39ms, retrospective gating, with an average of 8 heartbeats per slice and 1-2 slices/BH. For Cine-RT: acquisition matrix of 224×196, sparse sampling net acceleration factor of 11.3, temporal resolution of 41ms, prospective gating, real-time acquisition of 1 heart-beat/slice and all slices in one BH. LV contours were drawn at end diastole and systole to derive LV volumes and mass. Forty-one consecutive patients (15 male; 41±17years) in sinus rhythm were successfully included. All images from Cine-SSFP and Cine-RT were considered to have excellent quality. Cine-RT-derived LV volumes and mass were slightly underestimated but strongly correlated with gold standard Cine-SSFP. Inter- and intra-observer analysis presented similar results between both sequences. Cine-RT featuring sparse sampling and iterative reconstruction can achieve spatial and temporal resolution equivalent to Cine-SSFP, providing excellent image quality, with similar precision measurements and highly correlated and only slightly underestimated volume and mass values. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Evaluation of a Commercial Sandwich Enzyme-Linked Immunosorbent Assay for the Quantification of Beta-Casomorphin 7 in Yogurt Using Solid-Phase Extraction Coupled to Liquid Chromatography-Tandem Mass Spectrometry as the "Gold Standard" Method.

    Science.gov (United States)

    Nguyen, Duc Doan; Busetti, Francesco; Johnson, Stuart Keith; Solah, Vicky Ann

    2018-03-01

    This study investigated beta-casomorphin 7 (BCM7) in yogurt by means of LC-tandem MS (MS/MS) and enzyme-linked immunosorbent assay (ELISA) and use LC-MS/MS as the "gold standard" method to evaluate the applicability of a commercial ELISA. The level of BCM7 in milk obtained from ELISA analysis was much lower than that obtained by LC-MS/MS analysis and trended to increase during fermentation and storage of yogurt. Meanwhile, the results obtained from LC-MS/MS showed that BCM7 degraded during stages of yogurt processing, and its degradation may have been caused by X-prolyl dipeptidyl aminopeptidase activity. As a result, the commercial sandwich ELISA kit was not suitable for the quantification of BCM7 in fermented dairy milk.

  10. Lamellar multilayer hexadecylaniline-modified gold nanoparticle ...

    Indian Academy of Sciences (India)

    standard Wilhelmy plate was used for surface pressure sensing. Multilayer ... carried out on a JEOL model 1200EX instrument operated at an accelerating voltage of ... the gold nanoparticles within domains (and reorganization of the domains ...

  11. 40 CFR 792.61 - Equipment design.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Equipment design. 792.61 Section 792.61...) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.61 Equipment design. Equipment used in the... of appropriate design and adequate capacity to function according to the protocol and shall be...

  12. 40 CFR 160.61 - Equipment design.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Equipment design. 160.61 Section 160... LABORATORY PRACTICE STANDARDS Equipment § 160.61 Equipment design. Equipment used in the generation... appropriate design and adequate capacity to function according to the protocol and shall be suitably located...

  13. Chapter 12. Space Heating Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, Kevin D.

    1998-01-01

    The performance evaluation of space heating equipment for a geothermal application is generally considered from either of two perspectives: (a) selecting equipment for installation in new construction, or (b) evaluating the performance and retrofit requirements of an existing system. With regard to new construction, the procedure is relatively straightforward. Once the heating requirements are determined, the process need only involve the selection of appropriately sized hot water heating equipment based on the available water temperature. It is important to remember that space heating equipment for geothermal applications is the same equipment used in non-geothermal applications. What makes geothermal applications unique is that the equipment is generally applied at temperatures and flow rates that depart significantly from traditional heating system design. This chapter presents general considerations for the performance of heating equipment at non-standard temperature and flow conditions, retrofit of existing systems, and aspects of domestic hot water heating.

  14. A Preliminary Study on Detecting Fake Gold Bars Using Prompt Gamma Activation Analysis: Simulation of Neutron Transmission in Gold Bar

    International Nuclear Information System (INIS)

    Lee, K. M.; Sun, G. M.

    2016-01-01

    The purpose of this study is to develop fake gold bar detecting method by using Prompt-gamma activation analysis (PGAA) facility at the Korea Atomic Energy Research Institute (KAERI). PGAA is an established nuclear analytical technique for non-destructive determination of elemental and isotopic compositions. For a preliminary study on detecting fake gold bar, Monte Carlo simulation of neutron transmission in gold bar was conducted and the possibility for detecting fake gold bar was confirmed. Under the gold bullion standard, it guaranteed the government would redeem any amount of currency for its value in gold. After the gold bullion standard ended, gold bars have been the target for investment as ever. But it is well known that fake gold bar exist in the gold market. This cannot be identified easily without performing a testing as it has the same appearance as the pure gold bar. In order to avoid the trading of fake gold bar in the market, they should be monitored thoroughly. Although the transmissivity of cold neutrons are low comparing that of thermal neutrons, the slower neutrons are more apt to be absorbed in a target, and can increase the prompt gamma emission rate. Also the flux of both thermal and cold neutron beam is high enough to activate thick target. If the neutron beam is irradiated on the front and the reverse side of gold bar, all insides of it can be detected

  15. A Preliminary Study on Detecting Fake Gold Bars Using Prompt Gamma Activation Analysis: Simulation of Neutron Transmission in Gold Bar

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K. M.; Sun, G. M. [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    The purpose of this study is to develop fake gold bar detecting method by using Prompt-gamma activation analysis (PGAA) facility at the Korea Atomic Energy Research Institute (KAERI). PGAA is an established nuclear analytical technique for non-destructive determination of elemental and isotopic compositions. For a preliminary study on detecting fake gold bar, Monte Carlo simulation of neutron transmission in gold bar was conducted and the possibility for detecting fake gold bar was confirmed. Under the gold bullion standard, it guaranteed the government would redeem any amount of currency for its value in gold. After the gold bullion standard ended, gold bars have been the target for investment as ever. But it is well known that fake gold bar exist in the gold market. This cannot be identified easily without performing a testing as it has the same appearance as the pure gold bar. In order to avoid the trading of fake gold bar in the market, they should be monitored thoroughly. Although the transmissivity of cold neutrons are low comparing that of thermal neutrons, the slower neutrons are more apt to be absorbed in a target, and can increase the prompt gamma emission rate. Also the flux of both thermal and cold neutron beam is high enough to activate thick target. If the neutron beam is irradiated on the front and the reverse side of gold bar, all insides of it can be detected.

  16. MR imaging of the articular cartilage of the knee with arthroscopy as gold standard: assessment of methodological quality of clinical studies

    International Nuclear Information System (INIS)

    Duchateau, Florence; Berg, Bruno C. vande

    2002-01-01

    The purpose of this study was to assess the methodological quality of articles addressing the value of MR imaging of the knee cartilage with arthroscopy as a standard. Relevant papers were selected after Medline review (MEDLINE database search including the terms ''cartilage'' ''knee'', ''MR'' and ''arthroscopy''). Two observers reviewed independently 29 selected articles to determine how each study had met 15 individual standards that had been previously developed to assess the methodological quality of clinical investigations. The following criteria were met in variable percentage of articles including adequate definition of purpose (100%), statistical analysis (90%), avoidance of verification bias (86%), patient population description (83%), reference standard (79%), review bias (79%), study design (66%), inclusion criteria (41%) and method of analysis (41.5%), avoidance of diagnostic-review bias (24%), exclusion criteria (21%), indeterminate examination results (17%), analysis criteria (14%), interobserver reliability (14%) and intraobserver reliability (7%). The assessment of the methodological quality of clinical investigations addressing the value of MR imaging in the evaluation of the articular cartilage of the knee with arthroscopy as the standard of reference demonstrated that several standards were rarely met in the literature. Efforts should be made to rely on clearly defined lesion criteria and to determine reliability of the observations. (orig.)

  17. CMS Industries awarded gold, crystal

    CERN Multimedia

    2006-01-01

    The CMS collaboration honoured 10 of its top suppliers in the seventh annual awards ceremony The representatives of the firms that recieved the CMS Gold and Crystal Awards stand with their awards after the ceremony. The seventh annual CMS Awards ceremony was held on Monday 13 March to recognize the industries that have made substantial contributions to the construction of the collaboration's detector. Nine international firms received Gold Awards, and General Tecnica of Italy received the prestigious Crystal Award. Representatives from the companies attended the ceremony during the plenary session of CMS week. 'The role of CERN, its machines and experiments, beyond particle physics is to push the development of equipment technologies related to high-energy physics,'said CMS Awards Coordinator Domenico Campi. 'All of these industries must go beyond the technologies that are currently available.' Without the involvement of good companies over the years, the construction of the CMS detector wouldn't be possible...

  18. Radioactive decontamination of equipment

    International Nuclear Information System (INIS)

    1982-03-01

    After a recall of some definitions relating to decontamination techniques and of the regulation into effect, the principles to be respected to arrange rationally work zones are quoted while insisting more particularly on the types of coatings which facilitate maintenance operations and the dismantling of these installations. Then, the processes and equipments to use in decontamination units for routine or particular operations are described; the list of recommended chemical products to decontaminate the equipment is given. The influence of these treatments on the state and the duration of life of equipments is studied, and some perfectible methods are quoted. In the appendix, are given: the limits of surface contamination accepted in the centers; a standard project which defines the criteria of admissible residual contamination in wastes considered as cold wastes; some remarks on the interest that certain special ventilation and air curtain devices for the protection of operators working on apparatus generating contaminated dusts [fr

  19. A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasible.

    NARCIS (Netherlands)

    Hooijmans, C.R.; Leenaars, M.; Ritskes-Hoitinga, M.

    2010-01-01

    Systematic reviews are generally regarded by professionals in the field of evidence-based medicine as the highest level of medical evidence, and they are already standard practice for clinical studies. However, they are not yet widely used nor undertaken in the field of animal experimentation, even

  20. Can the Movement Assessment Battery for Children-Test Be the "Gold Standard" for the Motor Assessment of Children with Developmental Coordination Disorder?

    Science.gov (United States)

    Venetsanou, Fotini; Kambas, Antonis; Ellinoudis, Theodoros; Fatouros, Ioannis; Giannakidou, Dimitra; Kourtessis, Thomas

    2011-01-01

    Developmental Coordination Disorder (DCD) is an important risk factor in the development of children that can have a significant academic and social impact. This reinforces the need for its timely identification using appropriate assessment methods and accurate screening tests. The commonly used standardized motor test for the DCD identification…

  1. [Hydrotherapy equipment].

    Science.gov (United States)

    Tsibikov, V B; Ragozin, S I; Mikheeva, L V

    1985-01-01

    A flow-chart is developed demonstrating the relation between medical and prophylactic institutions within the organizational structure of the rehabilitation system and main types of rehabilitation procedures. In order to ascertain the priority in equipping rehabilitation services with adequate hardware the special priority criterion is introduced. The highest priority is assigned to balneotherapeutic and fangotherapeutic services. Based on the operation-by-operation analysis of clinical processes related to service and performance of balneologic procedures the preliminary set of clinical devices designed for baths, basins and showers in hospitals and rehabilitation departments is defined in a generalized form.

  2. Determination of gold coating thickness measurement by using EDXRF

    International Nuclear Information System (INIS)

    Meor Yusoff Meor Sulaian; Masliana Muslimin; Fadlullah Jili Fursani

    2005-01-01

    The paper relates a study on the development of an analysis procedure for measuring the gold coating thickness using EDXRF technique. Gold coating thickness was measured by relating the counts under the Au L? peak its thickness value. In order to get a reasonably accurate result, a calibration graph was plotted using five gold-coated reference standards of different thickness. The calibration graph shows a straight line for thin coating measurement until 0.9 μm. Beyond this the relationship was not linear and this may be resulted from the self-absorption effect. Quantitative analysis was also performed on two different samples of gold coated jewelry and a phone connector. Result from the phone connector analysis seems to agree with the manufacturer gold coating value. From the analysis of gold-coated jewelry it had been able to differentiate the two articles as gold wash and gold electroplated. (Author)

  3. Management methodology for pressure equipment

    Science.gov (United States)

    Bletchly, P. J.

    Pressure equipment constitutes a significant investment in capital and a major proportion of potential high-risk plant in many operations and this is particularly so in an alumina refinery. In many jurisdictions pressure equipment is also subject to statutory regulation that imposes obligations on Owners of the equipment with respect to workplace safety. Most modern technical standards and industry codes of practice employ a risk-based approach to support better decision making with respect to pressure equipment. For a management system to be effective it must demonstrate that risk is being managed within acceptable limits.

  4. Report on results 1998. Standardization of test measuring method of fine ceramics for communication equipment; 1998 nendo seika hokokusho. Tsushin kikiyo fine ceramics no shiken hyoka hoho no hyojunka

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Technological development is in progress at present for the intelligent transport system for example that uses a microwave frequency range of 60GHz or 90GHz toward the practical use, with a demand increasing for measuring the electrical properties of fine ceramics (FC) to be used in the communication equipment of the system. The measuring method in the microwave frequency range of 30GHz or less is about to be standardized in IEC TC49/WG10; however, the method above 30GHz has not yet been examined for the standardization internationally. The subject research is intended to establish the method of measuring electrical properties such as the dielectric constant of FC for a high-frequency/ultra high-frequency wave range, dielectric loss and surface resistivity, to standardize the principle of their measuring methods, measuring tools, adjusting method of samples, procedures of measurement, etc., and to aim at the international standardization. This year, investigation and examination were carried out on various measuring methods including overseas examinations in the U.S., extracting the Fabry-Perot resonator method and a conductive cylindrical dielectric cavity resonator perturbation method for example, and evaluating the specifications of standard reference materials. In addition, a morphological technique was established for measuring sample surfaces affecting measurements, by means of an accurate measuring instrument for thin film surfaces. (NEDO)

  5. Phytomining for Artisanal Gold Mine Tailings Management

    Directory of Open Access Journals (Sweden)

    Baiq Dewi Krisnayanti

    2016-08-01

    Full Text Available Mine tailings are generally disposed of by artisanal and small scale gold miners in poorly constructed containment areas and this leads to environmental risk. Gold phytomining could be a possible option for tailings management at artisanal and small-scale gold mining (ASGM locations where plants accumulate residual gold in their above ground biomass. The value of metal recovered from plants could offset some of the costs of environmental management. Getting gold into plants has been repeatedly demonstrated by many research groups; however, a simple working technology to get gold out of plants is less well described. A field experiment to assess the relevance of the technology to artisanal miners was conducted in Central Lombok, Indonesia between April and June 2015. Tobacco was planted in cyanidation tailings (1 mg/kg gold and grown for 2.5 months before the entire plot area was irrigated with NaCN to induce metal uptake. Biomass was then harvested (100 kg, air dried, and ashed by miners in equipment currently used to ash activated carbon at the end of a cyanide leach circuit. Borax and silver as a collector metal were added to the tobacco ash and smelted at high temperature to extract metals from the ash. The mass of the final bullion (39 g was greater than the mass of silver used as a collector (31 g, indicating recovery of metals from the biomass through the smelt process. The gold yield of this trial was low (1.2 mg/kg dry weight biomass concentration, indicating that considerable work must still be done to optimise valuable metal recovery by plants at the field scale. However, the described method to process the biomass was technically feasible, and represents a valid technique that artisanal and small-scale gold miners are willing to adopt if the economic case is good.

  6. 9 CFR 590.502 - Equipment and utensils; PCB-containing equipment.

    Science.gov (United States)

    2010-01-01

    ... Sanitary Standards and accepted practices currently in effect for such equipment. (c) New or replacement equipment or machinery (including any replacement parts) brought onto the premises of any official plant... equipment and machinery, and any replacement parts for such equipment and machinery. Totally enclosed...

  7. Frontiers in Gold Chemistry

    OpenAIRE

    Ahmed A. Mohamed

    2015-01-01

    Basic chemistry of gold tells us that it can bond to sulfur, phosphorous, nitrogen, and oxygen donor ligands. The Frontiers in Gold Chemistry Special Issue covers gold complexes bonded to the different donors and their fascinating applications. This issue covers both basic chemistry studies of gold complexes and their contemporary applications in medicine, materials chemistry, and optical sensors. There is a strong belief that aurophilicity plays a major role in the unending applications of g...

  8. Staging Hemodynamic Failure With Blood Oxygen-Level-Dependent Functional Magnetic Resonance Imaging Cerebrovascular Reactivity: A Comparison Versus Gold Standard (15O-)H2O-Positron Emission Tomography.

    Science.gov (United States)

    Fierstra, Jorn; van Niftrik, Christiaan; Warnock, Geoffrey; Wegener, Susanne; Piccirelli, Marco; Pangalu, Athina; Esposito, Giuseppe; Valavanis, Antonios; Buck, Alfred; Luft, Andreas; Bozinov, Oliver; Regli, Luca

    2018-03-01

    Increased stroke risk correlates with hemodynamic failure, which can be assessed with ( 15 O-)H 2 O positron emission tomography (PET) cerebral blood flow (CBF) measurements. This gold standard technique, however, is not established for routine clinical imaging. Standardized blood oxygen-level-dependent (BOLD) functional magnetic resonance imaging+CO 2 is a noninvasive and potentially widely applicable tool to assess whole-brain quantitative cerebrovascular reactivity (CVR). We examined the agreement between the 2 imaging modalities and hypothesized that quantitative CVR can be a surrogate imaging marker to assess hemodynamic failure. Nineteen data sets of subjects with chronic cerebrovascular steno-occlusive disease (age, 60±11 years; 4 women) and unilaterally impaired perfusion reserve on Diamox-challenged ( 15 O-)H 2 O PET were studied and compared with a standardized BOLD functional magnetic resonance imaging+CO 2 examination within 6 weeks (8±19 days). Agreement between quantitative CBF- and CVR-based perfusion reserve was assessed. Hemodynamic failure was staged according to PET findings: stage 0: normal CBF, normal perfusion reserve; stage I: normal CBF, decreased perfusion reserve; and stage II: decreased CBF, decreased perfusion reserve. The BOLD CVR data set of the same subjects was then matched to the corresponding stage of hemodynamic failure. PET-based stage I versus stage II could also be clearly separated with BOLD CVR measurements (CVR for stage I 0.11 versus CVR for stage II -0.03; P the affected hemisphere and middle cerebral artery territory ( P the affected hemisphere and middle cerebral artery territory and for identifying hemodynamic failure stage II. BOLD CVR may, therefore, be considered for prospective studies assessing stroke risk in patients with chronic cerebrovascular steno-occlusive disease, in particular because it can potentially be implemented in routine clinical imaging. © 2018 American Heart Association, Inc.

  9. Mobile gait analysis via eSHOEs instrumented shoe insoles: a pilot study for validation against the gold standard GAITRite®.

    Science.gov (United States)

    Jagos, Harald; Pils, Katharina; Haller, Michael; Wassermann, Claudia; Chhatwal, Christa; Rafolt, Dietmar; Rattay, Frank

    2017-07-01

    Clinical gait analysis contributes massively to rehabilitation support and improvement of in-patient care. The research project eSHOE aspires to be a useful addition to the rich variety of gait analysis systems. It was designed to fill the gap of affordable, reasonably accurate and highly mobile measurement devices. With the overall goal of enabling individual home-based monitoring and training for people suffering from chronic diseases, affecting the locomotor system. Motion and pressure sensors gather movement data directly on the (users) feet, store them locally and/or transmit them wirelessly to a PC. A combination of pattern recognition and feature extraction algorithms translates the motion data into standard gait parameters. Accuracy of eSHOE were evaluated against the reference system GAITRite in a clinical pilot study. Eleven hip fracture patients (78.4 ± 7.7 years) and twelve healthy subjects (40.8 ± 9.1 years) were included in these trials. All subjects performed three measurements at a comfortable walking speed over 8 m, including the 6-m long GAITRite mat. Six standard gait parameters were extracted from a total of 347 gait cycles. Agreement was analysed via scatterplots, histograms and Bland-Altman plots. In the patient group, the average differences between eSHOE and GAITRite range from -0.046 to 0.045 s and in the healthy group from -0.029 to 0.029 s. Therefore, it can be concluded that eSHOE delivers adequately accurate results. Especially with the prospect as an at home supplement or follow-up to clinical gait analysis and compared to other state of the art wearable motion analysis systems.

  10. Gold in plants

    International Nuclear Information System (INIS)

    Girling, C.A.; Peterson, P.J.

    1980-01-01

    Many plants have the ability to take up gold from the soil and to accumulate it in their tisssue. Advances have been made in understanding these processes to the point where their exploitation in the field of prospecting for gold appears practically feasible. Neutron activation analysis is used for the determination of the small quantities of gold in plants

  11. Low-cost mercury (II) ion sensor by biosynthesized gold nanoparticles (AuNPs)

    Science.gov (United States)

    Guerrero, Jet G.; Candano, Gabrielle Jackie; Mendoza, Aileen Nicole; Paderanga, Marciella; Cardino, Krenz John; Locsin, Alessandro; Bibon, Cherilou

    2017-11-01

    Biosynthesis of gold nanoparticles has attracted the curiosity of scientists over the past few decades. Nanoparticles have been proven to exhibit enhanced properties and offer a variety of applications in different fields of study. Utilizing nanoparticles instead of bulky equipment and noxious chemicals has become more convenient; reagents needed for synthesis have been proven to be benign (mostly aqueous solutions) and are cost-effective. In this study, gold nanoparticles were biosynthesized using guyabano (Annonamuricata) peel samples as the source of reducing agents. The optimum concentration ratio of gold chloride to guyabano extract was determined to be 1:7. Characterization studies were accomplished using UV Vis Spectroscopy, Fourier Transform Electron Microscopy (FTIR) and Scanning Electron Microscopy (SEM). Spectroscopic maximum absorbance was found to be at 532 nm thereby confirming the presence of gold nanoparticles. Hydroxyl (O-H stretching), carbonyl (C=O stretching), and amide (N-H stretching) functional groups shown in the FTIR spectra are present on possible reducing agents such as phenols, alkaloids, and saponins found in the plant extract. SEM images revealed spherical shaped nanoparticles with mean diameter of 23.18 nm. It was observed that the bio-synthesized AuNPs were selective to mercury ions through uniform color change from wine red to yellow. A novel smartphone-based mercury (II) ions assay was developed using the gold nanoparticles. A calibration curve correlated the analytical response (Red intensity) to the concentrations of Hg 2+ ions. Around 94% of the variations in the intensity is accounted for by the variations in the concentration of mercury (II) ions suggesting a good linear relationship between the two variables. A relative standard deviation (RSD) of less than 1% was achieved at all individual points. The metal sensor displayed a sensitivity of 0.039 R.I./ppm with an LOD of 93.79 ppm. Thus, the bio-fabricated gold nanoparticles

  12. The Modern Monetary System and Gold

    Directory of Open Access Journals (Sweden)

    N N Rubtsov

    2013-12-01

    Full Text Available The article considers the nature of modern money, analyzes the mechanism of its creation, showing that it is basically generated by credit and the principle of partial bank reserve. The article draws comparative parallels between trade money based on gold and contemporary, credit money; the author quotes leading bankers and finance experts on the need for partial return to the principles of functioning of the gold standard as the most effective institute of regulating the monetary system in society.

  13. The effect of signal acquisition and processing choices on ApEn values: towards a "gold standard" for distinguishing effort levels from isometric force records.

    Science.gov (United States)

    Forrest, Sarah M; Challis, John H; Winter, Samantha L

    2014-06-01

    Approximate entropy (ApEn) is frequently used to identify changes in the complexity of isometric force records with ageing and disease. Different signal acquisition and processing parameters have been used, making comparison or confirmation of results difficult. This study determined the effect of sampling and parameter choices by examining changes in ApEn values across a range of submaximal isometric contractions of the first dorsal interosseus. Reducing the sample rate by decimation changed both the value and pattern of ApEn values dramatically. The pattern of ApEn values across the range of effort levels was not sensitive to the filter cut-off frequency, or the criterion used to extract the section of data for analysis. The complexity increased with increasing effort levels using a fixed 'r' value (which accounts for measurement noise) but decreased with increasing effort level when 'r' was set to 0.1 of the standard deviation of force. It is recommended isometric force records are sampled at frequencies >200Hz, template length ('m') is set to 2, and 'r' set to measurement system noise or 0.1SD depending on physiological process to be distinguished. It is demonstrated that changes in ApEn across effort levels are related to changes in force gradation strategy. Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.

  14. Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the 'Gold Standard' Tarnished?

    Science.gov (United States)

    Demmer, Denise L; Beilin, Lawrence J; Hands, Beth; Burrows, Sally; Pennell, Craig E; Lye, Stephen J; Mountain, Jennifer A; Mori, Trevor A

    2016-01-01

    Assessment of adiposity using dual energy x-ray absorptiometry (DXA) has been considered more advantageous in comparison to anthropometry for predicting cardio-metabolic risk in the older population, by virtue of its ability to distinguish total and regional fat. Nonetheless, there is increasing uncertainty regarding the relative superiority of DXA and little comparative data exist in young adults. This study aimed to identify which measure of adiposity determined by either DXA or anthropometry is optimal within a range of cardio-metabolic risk factors in young adults. 1138 adults aged 20 years were assessed by DXA and standard anthropometry from the Western Australian Pregnancy Cohort (Raine) Study. Cross-sectional linear regression analyses were performed. Waist to height ratio was superior to any DXA measure with HDL-C. BMI was the superior model in relation to blood pressure than any DXA measure. Midriff fat mass (DXA) and waist circumference were comparable in relation to glucose. For all the other cardio-metabolic variables, anthropometric and DXA measures were comparable. DXA midriff fat mass compared with BMI or waist hip ratio was the superior measure for triglycerides, insulin and HOMA-IR. Although midriff fat mass (measured by DXA) was the superior measure with insulin sensitivity and triglycerides, the anthropometric measures were better or equal with various DXA measures for majority of the cardio-metabolic risk factors. Our findings suggest, clinical anthropometry is generally as useful as DXA in the evaluation of the individual cardio-metabolic risk factors in young adults.

  15. Lifetime of Mechanical Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Leland, K.

    1999-07-01

    The gas plant at Kaarstoe was built as part of the Statpipe gas transport system and went on stream in 1985. In 1993 another line was routed from the Sleipner field to carry condensate, and the plant was extended accordingly. Today heavy additional supply- and export lines are under construction, and the plant is extended more than ever. The main role of the factory is to separate the raw gas into commercial products and to pump or ship it to the markets. The site covers a large number of well-known mechanical equipment. This presentation deals with piping, mechanical and structural disciplines. The lifetime of mechanical equipment is often difficult to predict as it depends on many factors, and the subject is complex. Mechanical equipment has been kept in-house, which provides detailed knowledge of the stages from a new to a 14 years old plant. The production regularity has always been very high, as required. The standard of the equipment is well kept, support systems are efficient, and human improvisation is extremely valuable.

  16. Study on Sumbawa gold recovery using centrifuge

    Science.gov (United States)

    Ferdana, A. D.; Petrus, H. T. B. M.; Bendiyasa, I. M.; Prijambada, I. D.; Hamada, F.; Sachiko, T.

    2018-01-01

    The Artisanal Small Gold Mining in Sumbawa has been processing gold with mercury (Hg), which poses a serious threat to the mining and global environment. One method of gold processing that does not use mercury is by gravity method. Before processing the ore first performed an analysis of Mineragraphy and analysis of compound with XRD. Mineragraphy results show that gold is associated with chalcopyrite and covelite and is a single particle (native) on size 58.8 μm, 117 μm up to 294 μm. characterization with XRD shows that the Sumbawa Gold Ore is composed of quartz, pyrite, pyroxene, and sericite compounds. Sentrifugation is one of separation equipment of gravity method to increase concentrate based on difference of specific gravity. The optimum concentration result is influenced by several variables, such as water flow rate and particle size. In this present research, the range of flow rate is 5 lpm and 10 lpm, the particle size - 100 + 200 mesh and -200 +300 mesh. Gold concentration in concentrate is measured by EDX. The result shows that the optimum condition is obtained at a separation with flow rate 5 lpm and a particle size of -100 + 200 mesh.

  17. Detection of aneurysmal subarachnoid hemorrhage 3 months after initial bleeding: evaluation of T2* and FLAIR MR sequences at 3 T in comparison with initial non-enhanced CT as a gold standard.

    Science.gov (United States)

    Mulé, Sébastien; Soize, Sébastien; Benaissa, Azzedine; Portefaix, Christophe; Pierot, Laurent

    2016-08-01

    To investigate the ability of T2* and fluid-attenuated inversion recovery (FLAIR) MR sequences to detect hemosiderin deposition 3 months after aneurysmal subarachnoid hemorrhage (SAH) in comparison with early non-enhanced CT (NECT) as a gold standard. From September 2008 through May 2013, patients with aneurysmal SAH were included if a NECT less than 24 h after the onset of symptoms showed a SAH, and MRI, including T2* and FLAIR sequences, was performed 3 months later. All aneurysms were treated endovascularly. NECT and MR sequences were blindly analyzed for the presence of SAH (NECT) or hemosiderin deposition (MRI). When positive, details of the spatial distribution of SAH or hemosiderin deposits were noted. Sensitivities were calculated for each patient. Sensitivities, specificities, and positive predictive values (PPVs) were calculated for each location. Forty-nine patients (mean age 52.9 years) were included. Bleeding-related patterns were identified in 43 patients (87.8%) on T2* and 10 patients (20.4%) on FLAIR. T2* was highly predictive of the location of the initial hemorrhage, especially in the Sylvian cisterns (PPVs 95% and 100%) and the anterior interhemispheric fissure (PPV 90%). The T2* sequence can detect and localize a previous SAH a few months after aneurysmal bleeding. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  18. Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the 'Gold Standard' Tarnished?

    Directory of Open Access Journals (Sweden)

    Denise L Demmer

    Full Text Available Assessment of adiposity using dual energy x-ray absorptiometry (DXA has been considered more advantageous in comparison to anthropometry for predicting cardio-metabolic risk in the older population, by virtue of its ability to distinguish total and regional fat. Nonetheless, there is increasing uncertainty regarding the relative superiority of DXA and little comparative data exist in young adults. This study aimed to identify which measure of adiposity determined by either DXA or anthropometry is optimal within a range of cardio-metabolic risk factors in young adults.1138 adults aged 20 years were assessed by DXA and standard anthropometry from the Western Australian Pregnancy Cohort (Raine Study. Cross-sectional linear regression analyses were performed. Waist to height ratio was superior to any DXA measure with HDL-C. BMI was the superior model in relation to blood pressure than any DXA measure. Midriff fat mass (DXA and waist circumference were comparable in relation to glucose. For all the other cardio-metabolic variables, anthropometric and DXA measures were comparable. DXA midriff fat mass compared with BMI or waist hip ratio was the superior measure for triglycerides, insulin and HOMA-IR.Although midriff fat mass (measured by DXA was the superior measure with insulin sensitivity and triglycerides, the anthropometric measures were better or equal with various DXA measures for majority of the cardio-metabolic risk factors. Our findings suggest, clinical anthropometry is generally as useful as DXA in the evaluation of the individual cardio-metabolic risk factors in young adults.

  19. Comparison between the gold standard DXA with calcaneal quantitative ultrasound based-strategy (QUS) to detect osteoporosis in an HIV infected cohort.

    Science.gov (United States)

    Quiros Roldan, Eugenia; Brianese, Nigritella; Raffetti, Elena; Focà, Emanuele; Pezzoli, Maria Chiara; Bonito, Andrea; Ferraresi, Alice; Lanza, Paola; Porcelli, Teresa; Castelli, Francesco

    Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. The aims of this study are to compare these two methods and to evaluate their ability to screen for vertebral fracture. This cross-sectional study was conducted in HIV patients attending the Clinic of Infectious and Tropical Diseases of Brescia during 2014 and who underwent lumbar/femoral dual-energy X-ray absorptiometry, vertebral fracture assessment and calcaneal quantitative ultrasound. The assessment of osteoporosis diagnostic accuracy was performed for calcaneal quantitative ultrasound and for vertebral fracture comparing them with dual-energy X-ray absorptiometry. We enrolled 73 patients and almost 48% of them had osteoporosis with at least one of the method used. Vertebral fracture were present in 27.4%. Among patients with normal bone measurements, we found vertebral fracture in proportion between 10% and 30%. If we used calcaneal quantitative ultrasound method and/or X-ray as screening, the percentages of possible savable dual-energy X-ray absorptiometry ranged from 12% to 89% and misclassification rates ranged from 0 to 24.6%. A combined strategy, calcaneal quantitative ultrasound and X-Ray, identified 67% of patients with low risk of osteoporosis, but 16.4% of patients were misclassified. We observed that patients with osteoporosis determined by calcaneal quantitative ultrasound and/or dual-energy X-ray absorptiometry have higher probability to undergo vertebral fracture, but neither of them can be used for predicting vertebral fracture. Use of calcaneal quantitative ultrasound for screening is a reasonable alternative of dual-energy X-ray absorptiometry since our study confirm that none strategy is clearly superior, but both screen tools must be always completed with X-ray. Copyright © 2017 Sociedade

  20. All That Glitters Is Not Gold

    CERN Multimedia

    2001-01-01

    The surface treatment lab team. From left to right, J. Carosone, M. Malabaila, J-P. Malivert (front row), M. Thiebert, and A. Lasserre (back row). Apiece of stainless steel equipment, destined for the LHC, was delivered to building 102 last Friday morning. This past Monday the equipment emerged from the same building in the afternoon, looking very much the same as it did when it arrived... with one small difference. The equipment was no longer steel, but gold. This may sound like medieval alchemy, but not all is as it appears. In fact there is no sorcery involved, just lots of careful chemical engineering. No wizards either, but rather a talented team of individuals... the CERN surface treatment lab group. Copper, silver, and gold are all incredibly important to particle physics projects because of their ability to conduct electricity with very low resistance. Unfortunately, these metals are also expensive and cannot be used frequently in large quantities. So instead of building equipment out of gold, equi...

  1. Medical Issues: Equipment

    Science.gov (United States)

    ... Information Packets Equipment Pool Living With SMA Medical Issues Palliative Breathing Orthopedics Nutrition Equipment Daily Life At ... curesma.org > support & care > living with sma > medical issues > equipment Equipment Individuals with SMA often require a ...

  2. Semiconductor Manufacturing equipment introduction

    International Nuclear Information System (INIS)

    Im, Jong Sun

    2001-02-01

    This book deals with semiconductor manufacturing equipment. It is comprised of nine chapters, which are manufacturing process of semiconductor device, history of semiconductor manufacturing equipment, kinds and role of semiconductor manufacturing equipment, construction and method of semiconductor manufacturing equipment, introduction of various semiconductor manufacturing equipment, spots of semiconductor manufacturing, technical elements of semiconductor manufacturing equipment, road map of technology of semiconductor manufacturing equipment and semiconductor manufacturing equipment in the 21st century.

  3. RIVES AND LICHTENSTEIN REPAIR IN INGUINAL HERNIA- A COMPARISON OF POSTOPERATIVE COMPLICATIONS TO KNOW WHETHER RIVES REPAIR IS AS SAFE AS THE GOLD STANDARD LICHTENSTEIN REPAIR

    Directory of Open Access Journals (Sweden)

    John S. Kurien

    2018-02-01

    Full Text Available BACKGROUND Hernia repair surgeries underwent a lot of modifications over time. These modifications were an attempt to reduce the recurrence rate and post-operative complications. Current techniques for Inguinal hernia show similar recurrence rate. Therefore, recurrence is no longer the main issue discussed when considering improving the current standards for groin hernia repair. Post-surgical chronic pain presents a major, largely unrecognized clinical problem. Consequently, there is a need to not only decrease an extensive dissection in the inguinal canal but also to minimize the interaction between the mesh and major surrounding structures. As a result, placing a mesh in the preperitoneal space is a viable option. Likewise, studies have shown that return to normal activity and return to work is comparatively quicker in Rives. In this study I am comparing the post op period complications in Rives and Lichtenstein hernia surgeries to know whether Rives is superior to Lichtenstein’s repair. MATERIALS AND METHODS After obtaining approval for the study from Institutional Review Board, written informed consent from 100 male patients planning to undergo elective hernia repair surgery at the General Surgery wards in Government Medical College, Kottayam & who were willing to participate in the study were obtained and randomly allocated into two groups, 50 undergoing Rives hernia repair & 50 Lichtenstein hernia repair. The patients were evaluated and followed up according to the protocol. In early postop period, patients were assessed for pain using a numeric rating scale. Complications like haematoma, seroma, wound infection and early recurrence were compared. Chronic inguinal pain/Inguinodynia is a significant, though under reported problem. Moderate to severe pain persisting more than 3 months should be considered pathological. Inguinodynia, if present was assessed using a numerical scale. Another parameter that was assessed was testicular atrophy

  4. 7 CFR 58.229 - Filler and packaging equipment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Filler and packaging equipment. 58.229 Section 58.229....229 Filler and packaging equipment. All filling and packaging equipment shall be of sanitary... equipment should comply with the 3-A Sanitary Standards for equipment for Packaging Dry Milk and Dry Milk...

  5. Moessbauer study of the chemical state of gold in gold ores

    International Nuclear Information System (INIS)

    Wagner, F.E.; Marion, P.H.; Regnard, J.-R.

    1986-01-01

    Information on the chemical state of gold in gold ores has been obtained by 197 Au Moessbauer spectroscopy in cases where the state of this element cannot be determined by such standard methods as optical or electron microscopy. Ore concentrates consisting mainly of pyrite or arsenopyrite and roasted ore and matte samples were studied. The results yielded directly the respective amounts of metallic and chemically bound gold. Unless the gold is metallic, its chemical state in the ores turns out to be different from that in the minerals studied so far as reference materials. The chemical processes taking place during various treatments of the ores, such as roasting or leaching, can also be followed by Moessbauer spectroscopy. It is hoped that Moessbauer spectroscopy will eventually facilitate the development of more efficient methods of gold extraction

  6. Preparation of radioactive colloidal gold 198Au

    International Nuclear Information System (INIS)

    Cammarosano, S.A.

    1979-01-01

    The preparation with simple equipment of radioactive colloidal gold of particle size about approximately 300 A from seed colloid stabilized by gelatine is described. Some physico-chemical parameters which can affect the process of formation of these colloidal particles are analysed; particle size has been meassured with an electron microscope. The colloid stability has been studied as a function of dilution, age and pH. Nucleation and growth of radioactive colloidal gold have been studied using spectrophotometry. Absorption spectra of the two ones are presented and compared. Quality control of the production process is verified through measurement of parameters, such as radioactive and radiochemical purity and biological distribution in laboratorial animals. This distribution was evalusted for rats injected endovenously with the gold colloidal solution.(Author) [pt

  7. Determination of Commercial Karats on Gold Alloys for Jewellery

    International Nuclear Information System (INIS)

    Morales, S.E.A.

    1986-12-01

    An XRF method for the gold content determination in gold alloys was proposed and tested. Gold coins and ingot samples were analyzed. Monoelemental standards and two pint regression curves calculated with the NBSGSC program, Cd-109 annular source, Si-Li detector, 4096 channels analyzer and AXIL deconvolution software were employed. Good precision better than 1.5% and accuracy better than 2% were obtained. (author)

  8. Nanobubble trouble on gold surfaces

    DEFF Research Database (Denmark)

    Holmberg, Maria; Kuhle, A.; Garnaes, J.

    2003-01-01

    When analyzing surfaces related to biosensors with in situ atomic force microscopy (AFM), the existence of nanobubbles called for our attention. The bubbles seem to form spontaneously when gold surfaces are immersed in clean water and are probably a general phenomenon at water-solid interfaces....... Besides from giving rise to undesired effects in, for example, biosensors, nanobubbles can also cause artifacts in AFM imaging. We have observed nanobubbles on unmodified gold surfaces, immersed in clean water, using standard silicon AFM probes. Nanobubbles can be made to disappear from contact mode AFM...... images and then to reappear by changing the scanning force. By combining contact mode AFM imaging and local force measurements, the interaction between the nanobubbles and the probe can be analyzed and give information about the characteristics of nanobubbles. A model of the forces between the AFM probe...

  9. Gold and uranium extraction

    International Nuclear Information System (INIS)

    James, G.S.; Davidson, R.J.

    1977-01-01

    A process for extracting gold and uranium from an ore containing them both comprising the steps of pulping the finely comminuted ore with a suitable cyanide solution at an alkaline pH, acidifying the pulp for uranium dissolution, adding carbon activated for gold recovery to the pulp at a suitable stage, separating the loaded activated carbon from the pulp, and recovering gold from the activated carbon and uranium from solution

  10. Gold mineralogy and extraction

    Energy Technology Data Exchange (ETDEWEB)

    Cashion, J.D.; Brown, L.J. [Monash University, Physics Department (Australia)

    1998-12-15

    Several examples are examined in which Moessbauer spectroscopic analysis of gold mineral samples, treated concentrates and extracted species has provided information not obtainable by competing techniques. Descriptions are given of current work on bacterial oxidation of pyritic ores and on the adsorbed species from gold extracted from cyanide and chloride solutions onto activated carbon and polyurethane foams. The potential benefits for the gold mining industry from Moessbauer studies and some limitations on the use of the technique are also discussed.

  11. Gold mineralogy and extraction

    International Nuclear Information System (INIS)

    Cashion, J.D.; Brown, L.J.

    1998-01-01

    Several examples are examined in which Moessbauer spectroscopic analysis of gold mineral samples, treated concentrates and extracted species has provided information not obtainable by competing techniques. Descriptions are given of current work on bacterial oxidation of pyritic ores and on the adsorbed species from gold extracted from cyanide and chloride solutions onto activated carbon and polyurethane foams. The potential benefits for the gold mining industry from Moessbauer studies and some limitations on the use of the technique are also discussed

  12. Haugh Unit: Gold Standard of Egg Quality

    Science.gov (United States)

    Rapidly determining shell egg quality in an objective manner is not an easy task. Candling is most often utilized as a quick method for assessing egg quality in a non-destructive manner, but it is a highly subjective method. As you have experienced this week, when candling, it is almost impossibl...

  13. Education Schools Need a Gold Standard

    Science.gov (United States)

    Fraser, James W.

    2009-01-01

    Reform of teacher preparation is once again in the air. In his first major speech about education, President Obama said that "recruiting, preparing, and rewarding outstanding teachers" will be one of the new administration's top priorities. The priorities set forth in the stimulus package, as well as the Congressional debates about the…

  14. Real Exchange Rates under the Gold Standard.

    OpenAIRE

    Diebold, Francis X; Husted, Steven; Rush, Mark

    1991-01-01

    Purchasing power parity is one of the most important equilibrium conditions in international macroeconomics. Empirically, it is also one of the most hotly contested. Numerous recent studies, for example, have sought to determine the validity of purchasing power parity using data from the post-Bretton-Woods float and have reached different conclusions. We assert that most such studies are flawed for two reasons. First, the post-1973 data contain, by definition, only a very limited amount of th...

  15. Pharmacokinetics of internally labeled monoclonal antibodies as a gold standard: comparison of biodistribution of 75Se-, 111In-, and 125I-labeled monoclonal antibodies in osteogenic sarcoma xenografts in nude mice

    International Nuclear Information System (INIS)

    Koizumi, M.; Endo, K.; Watanabe, Y.; Saga, T.; Sakahara, H.; Konishi, J.; Yamamuro, T.; Toyama, S.

    1989-01-01

    In order to know the true biodistribution of anti-tumor monoclonal antibodies, three monoclonal antibodies (OST6, OST7, and OST15) against human osteosarcoma and control antibody were internally labeled with 75Se by incubating [75Se]methionine and hybridoma cells. 75Se-labeled monoclonal antibodies were evaluated both in vitro and in vivo using the human osteogenic sarcoma cell line KT005, and the results were compared with those of 125I- and 111In-labeled antibodies. 75Se-, 125I- and 111In-labeled monoclonal antibodies had identical binding activities to KT005 cells, and the immunoreactivity was in the decreasing order of OST6, OST7, and OST15. On the contrary, in vivo tumor uptake (% injected dose/g) of 75Se- and 125I-labeled antibodies assessed using nude mice bearing human osteosarcoma KT005 was in the order of OST7, OST6, and OST15. In the case of 111In, the order was OST6, OST7, and OST15. High liver uptake was similarly seen with 75Se- and 111In-labeled antibodies, whereas 125I-labeled antibodies showed the lowest tumor and liver uptake. These data indicate that tumor targeting of antibody conjugates are not always predictable from cell binding studies due to the difference of blood clearance of labeled antibodies. Furthermore, biodistribution of both 111In- and 125I-labeled antibodies are not identical with internally labeled antibody. Admitting that internally labeled antibody is a ''gold standard'' of biodistribution of monoclonal antibody, high liver uptake of 111In-radiolabeled antibodies may be inherent to antibodies. Little, if any, increase in tumor-to-normal tissue ratios of antibody conjugates will be expected compared to those of 111In-labeled antibodies if stably coupled conjugates are administered i.v

  16. Selection of equipment for equipment qualification

    International Nuclear Information System (INIS)

    Torr, K.G.

    1989-01-01

    This report describes the methodology applied in selecting equipment in the special safety systems for equipment qualification in the CANDU 600 MW nuclear generating stations at Gentilly 2 and Point Lepreau. Included is an explanation of the selection procedure adopted and the rationale behind the criteria used in identifying the equipment. The equipment items on the list have been grouped into three priority categories as a planning aid to AECB staff for a review of the qualification status of the special safety systems

  17. Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone.

    Science.gov (United States)

    Capogrosso, Roberta Francesca; Cozzoli, Anna; Mantuano, Paola; Camerino, Giulia Maria; Massari, Ada Maria; Sblendorio, Valeriana Teresa; De Bellis, Michela; Tamma, Roberto; Giustino, Arcangela; Nico, Beatrice; Montagnani, Monica; De Luca, Annamaria

    2016-04-01

    Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of the amino acid taurine, in comparison with the gold standard α-methyl prednisolone (PDN). The rationale was to target the overproduction of reactive oxygen species (ROS) via disease-related pathways that are worsened by mechanical-metabolic impairment such as inflammation and over-activity of NADPH oxidase (NOX) (taurine and apocynin, respectively) or the failing ROS detoxification mechanisms via sirtuin-1 (SIRT1)-peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) (resveratrol). Resveratrol (100mg/kg i.p. 5days/week), apocynin (38mg/kg/day per os), taurine (1g/kg/day per os), and PDN (1mg/kg i.p., 5days/week) were administered for 4-5 weeks to mdx mice in parallel with a standard protocol of treadmill exercise and the outcome was evaluated with a multidisciplinary approach in vivo and ex vivo on pathology-related end-points and biomarkers of oxidative stress. Resveratrol≥taurine>apocynin enhanced in vivo mouse force similarly to PDN. All the compounds reduced the production of superoxide anion, assessed by dihydroethidium staining, with apocynin being as effective as PDN, and ameliorated electrophysiological biomarkers of oxidative stress. Resveratrol also significantly reduced plasma levels of creatine kinase and lactate dehydrogenase. Force of isolated muscles was little ameliorated. However, the three compounds improved histopathology of gastrocnemius muscle more than PDN. Taurine>apocynin>PDN significantly decreased activated NF-kB positive myofibers. Thus, compounds targeting NOX-ROS or SIRT1/PGC-1α pathways differently modulate clinically relevant DMD-related endpoints according to their mechanism of action. With the

  18. Plasmonic gold nanoparticles for detection of fungi and human cutaneous fungal infections.

    Science.gov (United States)

    Sojinrin, Tobiloba; Conde, João; Liu, Kangze; Curtin, James; Byrne, Hugh J; Cui, Daxiang; Tian, Furong

    2017-07-01

    Fungi, which are common in the environment, can cause a multitude of diseases. Warm, humid conditions allow fungi to grow and infect humans via the respiratory, digestive and reproductive tracts, genital area and other bodily interfaces. Fungi can be detected directly by microscopy, using the potassium hydroxide test, which is the gold standard and most popular method for fungal screening. However, this test requires trained personnel operating specialist equipment, including a fluorescent microscope and culture facilities. As most acutely infected patients seek medical attention within the first few days of symptoms, the optimal diagnostic test would be rapid and self-diagnostic simplifying and improving the therapeutic outcome. In suspensions of gold nanoparticles, Aspergillus niger can cause a colour change from red to blue within 2 min, as a result of changes in nanoparticle shape. A similar colour change was observed in the supernatant of samples of human toenails dispersed in water. Scanning electron microscopy, UV/Vis and Raman spectroscopy were employed to monitor the changes in morphology and surface plasmon resonance of the nanoparticles. The correlation of colour change with the fungal infection was analysed using the absorbance ratio at 520 nm/620 nm. We found a decrease in the ratio when the fungi concentration increased from 1 to 16 CFU/mL, with a detection limit of 10 CFU/mL. The test had an 80% sensitivity and a 95% specificity value for the diagnosis of athlete's foot in human patients. This plasmonic gold nanoparticle-based system for detection of fungal infections measures the change in shape of gold nanoparticles and generates coloured solutions with distinct tonality. Our application has the potential to contribute to self-diagnosis and hygiene control in laboratories/hospitals with fewer resources, just using the naked eye. Graphical abstract Colorimetric method for fungi detection with gold nano particles.

  19. BROOKHAVEN: High energy gold

    International Nuclear Information System (INIS)

    Bleser, Ed

    1992-01-01

    On April 24, Brookhaven's Alternating Gradient Synchrotron (AGS) started to deliver gold ions at 11.4 GeV per nucleon (2,000 GeV per ion) to experimenters who were delighted not only to receive the world's highest energy gold beam but also to receive it on schedule

  20. Some developments in the extraction of gold from Witwatersrand ores

    International Nuclear Information System (INIS)

    Laxen, P.A.

    1975-01-01

    The extraction of gold from most ores of the Witwatersrand has been consistently high - approximately 95 per cent - for many years. The present high price of gold has stimulated research and development into potential improvements of the standard procedures. The occurrence of the gold and its association with other minerals is described briefly. The Witwatersrand reefs also contain uranium and pyrite, and some of the improvements to the standard gold-extraction process are associated with the recovery or concentration of one or both of these valuable constituents. For instance, the 'reverse-leach' process, in which acid treatment for the extraction of uranium precedes cyanidation, results in improved gold extraction. Some concentration techniques used on the present residues from cyanidation offer promise in improving the overall gold recoveries. Thucholite is an important carrier of residual gold, and its recovery from some residues by flotation appears to be economically justifiable. Wet high-intensity magnetic separation has given promising results, in the laboratory and on the pilot plant, for the recovery of both uranium and gold from a number of cyanide tailings. The benefits of gravity concentration and of the application of empirical modelling to the gold-extraction process have been demonstrated by a mining group. Some developments in instrumentation for control during cyanidation are discussed briefly [af

  1. Application of the Fundamental Parameter Method for X-ray fluorescence analysis of gold jewellery alloys

    International Nuclear Information System (INIS)

    Le Hong Khiem

    2004-01-01

    The Fundamental Parameter Method has been used for the correction of the matrix effects for determination of the fineness of gold in the ternary Au-Ag-Cu yellow jewellery alloys. A computer code GOLDANA based on this algorithm has been developed for both data taking and on-line determining the fineness of gold jewellery. Only one ternary Au-Ag-Cu standard sample is required. The analysis performance has been tested by measurements conducted on certified gold reference materials, with the use of the fundamental method, could be used for quickly determining the gold concentration in gold jewellery alloys with an acceptable accuracy for the gold jewellery producers. (author)

  2. Hydraulic turbines and auxiliary equipment

    Energy Technology Data Exchange (ETDEWEB)

    Luo Gaorong [Organization of the United Nations, Beijing (China). International Centre of Small Hydroelectric Power Plants

    1995-07-01

    This document presents a general overview on hydraulic turbines and auxiliary equipment, emphasizing the turbine classification, in accordance with the different types of turbines, standard turbine series in China, turbine selection based on the basic data required for the preliminary design, general hill model curves, chart of turbine series and the arrangement of application for hydraulic turbines, hydraulic turbine testing, and speed regulating device.

  3. 40 CFR 440.140 - Applicability; description of the gold placer mine subcategory.

    Science.gov (United States)

    2010-07-01

    ... separation methods for recovering gold from placer deposits. (b) The provisions of this subpart M are not... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Applicability; description of the gold... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ORE MINING AND DRESSING POINT SOURCE CATEGORY Gold...

  4. Immobilization of gold nanoparticles on cell culture surfaces for safe and enhanced gold nanoparticle-mediated laser transfection

    Science.gov (United States)

    Kalies, Stefan; Heinemann, Dag; Schomaker, Markus; Gentemann, Lara; Meyer, Heiko; Ripken, Tammo

    2014-01-01

    Abstract. In comparison to standard transfection methods, gold nanoparticle-mediated laser transfection has proven to be a versatile alternative. This is based on its minor influence on cell viability and its high efficiency, especially for the delivery of small molecules like small interfering RNA. However, in order to transfer it to routine usage, a safety aspect is of major concern: The avoidance of nanoparticle uptake by the cells is desired. The immobilization of the gold nanoparticles on cell culture surfaces can address this issue. In this study, we achieved this by silanization of the appropriate surfaces and the binding of gold nanoparticles to them. Comparable perforation efficiencies to the previous approaches of gold nanoparticle-mediated laser transfection with free gold nanoparticles are demonstrated. The uptake of the immobilized particles by the cells is unlikely. Consequently, these investigations offer the possibility of bringing gold nanoparticle-mediated laser transfection closer to routine usage. PMID:25069006

  5. Reliable practical technique for in-situ rock stress measurements in deep gold mines.

    CSIR Research Space (South Africa)

    Stacey, TR

    1998-03-01

    Full Text Available The proposed primary output of this research project is the development of a set of equipment and method of in situ stress measurements in a high stress environment typical of the deep level gold mines....

  6. Developments of bacteria leaching technologies in uranium and gold ores at home and abroad

    International Nuclear Information System (INIS)

    Gao Renxi; Guan Zibin; Tian Shengjun

    2000-01-01

    The present development, including development of new leaching processes and equipment and soon, in bacteria leaching of uranium and gold ores at home and abroad are described. Opinions and advices are presented

  7. Medicinal gold compounds

    International Nuclear Information System (INIS)

    Parish, R.V.; Cottrill, S.M.

    1987-01-01

    A major use of gold compounds in the pharmaceutical industry is for anti-arthritic agents. The disease itself is not understood and little is known about the way in which the drugs act, but detailed pictures of the distribution of gold in the body are available, and some of the relevant biochemistry is beginning to emerge. The purpose of this article is to give a survey of the types of compounds presently employed in medicine, of the distribution of gold in the body which results from their use, and of some relevant chemistry. Emphasis is placed on results obtained in the last few years

  8. Artisanal and Small-Scale Gold Mining Without Mercury

    Science.gov (United States)

    Mercury-free techniques are safer for miners, their families and local communities. They can also help miners qualify for certification under fair-mined standards, potentially allowing them to market their gold at higher prices.

  9. MATE standardization

    Science.gov (United States)

    Farmer, R. E.

    1982-11-01

    The MATE (Modular Automatic Test Equipment) program was developed to combat the proliferation of unique, expensive ATE within the Air Force. MATE incorporates a standard management approach and a standard architecture designed to implement a cradle-to-grave approach to the acquisition of ATE and to significantly reduce the life cycle cost of weapons systems support. These standards are detailed in the MATE Guides. The MATE Guides assist both the Air Force and Industry in implementing the MATE concept, and provide the necessary tools and guidance required for successful acquisition of ATE. The guides also provide the necessary specifications for industry to build MATE-qualifiable equipment. The MATE architecture provides standards for all key interfaces of an ATE system. The MATE approach to the acquisition and management of ATE has been jointly endorsed by the commanders of Air Force Systems Command and Air Force Logistics Command as the way of doing business in the future.

  10. The 'Thin film of gold': monetary rules and policy credibility

    OpenAIRE

    Niall Ferguson; Moritz Schularick

    2012-01-01

    This paper asks whether developing countries can reap credibility gains from submitting policy to a strict monetary rule. Following earlier work, we look at the gold standard era (1880-1914) as a "natural experiment" to test whether adoption of a rule-based monetary framework such as the gold standard increased policy credibility. On the basis of the largest possible dataset covering almost sixty independent and colonial borrowers in the London market, we challenge the traditional view that g...

  11. Characterization of scale contrast of gold nanoparticles with the use of clinical computed tomography

    International Nuclear Information System (INIS)

    Badelli, Juliana C.; Miquellin, Charlie A.; Bezerra, Arandi G.; Orsato, Alexandre; Woiski, Thiago D.; Figueiredo, Bonald C.

    2015-01-01

    Binding nanoparticles with antibodies that have protein with affinity cancer cells, then insert them into a diseased tissue, the antibodies will lead the nanoparticles to the region with malignant cells. Being possible to see the committed region, the size of tissue involvement and if is occurring metastasis with diagnostic imaging methods. This study aimed to evaluate how you distributed the contrast range of a set of concentrations of gold nanoparticles (NP) using existing protocols in clinical computed tomography equipment. For the irradiation of NP was made a support in HDPE . Different concentrations of NP form prepared ranging from 0.01 to 10 mg / ml , and samples of distilled water , and calcium. The standard protocols of cranium and abdomen of a Toshiba equipment Aquillion 64 were used for obtaining the CT numbers (HU). The theoretical HU value of Gold nanoparticles for beam energy used was 47.4 HU calculated and compared with the values found . Of the results was not possible to notice a growing response from the HU NP as a function of increasing concentration, however you can view a range of HU according to these concentrations . Of different concentrations of 5 mg / mL is the one closest to the theoretical value obtained. These results are promising and demonstrate that there is a need for further experiments with the NP and the tomograph. (author)

  12. Characterization of scale contrast of gold nanoparticles with the use of clinical computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Badelli, Juliana C.; Miquellin, Charlie A.; Bezerra, Arandi G., E-mail: jubadellin@gmail.com, E-mail: charlie@utfpr.edu.br, E-mail: arandi@utfpr.edu.br [Universidade Tecnologica Federal do Parana (CPGEI/UTFPR), Curitiba, PR (Brazil); Orsato, Alexandre; Woiski, Thiago D.; Figueiredo, Bonald C., E-mail: orsato_ale@yahoo.co.uk, E-mail: Thiagodw@ibest.com.br [Instituto de Pesquisa Pele Pequeno Principe, Curitiba PR (Brazil)

    2015-07-01

    Binding nanoparticles with antibodies that have protein with affinity cancer cells, then insert them into a diseased tissue, the antibodies will lead the nanoparticles to the region with malignant cells. Being possible to see the committed region, the size of tissue involvement and if is occurring metastasis with diagnostic imaging methods. This study aimed to evaluate how you distributed the contrast range of a set of concentrations of gold nanoparticles (NP) using existing protocols in clinical computed tomography equipment. For the irradiation of NP was made a support in HDPE . Different concentrations of NP form prepared ranging from 0.01 to 10 mg / ml , and samples of distilled water , and calcium. The standard protocols of cranium and abdomen of a Toshiba equipment Aquillion 64 were used for obtaining the CT numbers (HU). The theoretical HU value of Gold nanoparticles for beam energy used was 47.4 HU calculated and compared with the values found . Of the results was not possible to notice a growing response from the HU NP as a function of increasing concentration, however you can view a range of HU according to these concentrations . Of different concentrations of 5 mg / mL is the one closest to the theoretical value obtained. These results are promising and demonstrate that there is a need for further experiments with the NP and the tomograph. (author)

  13. Gold nanoprobes for theranostics

    Science.gov (United States)

    Panchapakesan, Balaji; Book-Newell, Brittany; Sethu, Palaniappan; Rao, Madhusudhana; Irudayaraj, Joseph

    2011-01-01

    Gold nanoprobes have become attractive diagnostic and therapeutic agents in medicine and life sciences research owing to their reproducible synthesis with atomic level precision, unique physical and chemical properties, versatility of their morphologies, flexibility in functionalization, ease of targeting, efficiency in drug delivery and opportunities for multimodal therapy. This review highlights some of the recent advances and the potential for gold nanoprobes in theranostics. PMID:22122586

  14. Facts and Fantasies about Gold

    OpenAIRE

    Klement, Joachim

    2015-01-01

    Due to the increasing popularity of gold as an investment the demand for effective risk management techniques for gold investments has increased as well. In this paper we analyze several drivers of the price of gold that have been proposed in the past. Our analysis indicates that short-term volatility of the price of gold remains rather unpredictable with many of the explanations like the fund flows in physical gold ETF either unreliable or unstable over time. Our analysis suggests that there...

  15. Scientific Equipment Division - Overview

    International Nuclear Information System (INIS)

    Halik, J.

    2001-01-01

    Full text: The Scientific Equipment Division consists of the Design Group and the Mechanical Workshop. The activity of the Division includes the following: - designing of devices and equipment for experiments in physics, their mechanical construction and assembly. In particular, there are vacuum chambers and installations for HV and UHV; - maintenance and upgrading of the existing installations and equipment in our Institute; - participation of our engineers and technicians in design works, equipment assembly and maintenance for experiments in foreign laboratories. The Design Group is equipped with PC-computers and AutoCAD graphic software (release 2000 and Mechanical Desktop 4.0) and a AO plotter, what allows us to make drawings and 2- and 3-dimensional mechanical documentation to the world standards. The Mechanical Workshop can offer a wide range of machining and treatment methods with satisfactory tolerances and surface quality. It offers the following possibilities: - turning - cylindrical elements of a length up to 2000 mm and a diameter up to 400 mm, and also disc-type elements of a diameter up to 600 mm and a length not exceeding 300 mm; - milling - elements of length up to 1000 mm and gear wheels of diameter up to 300 mm; - grinding - flat surfaces of dimensions up to 300 mm x 1000 mm and cylindrical elements of a diameter up to 200 mm and a length up to 800 mm; - drilling - holes of a diameter up to 50 mm; - welding - electrical and gas welding, including TIG vacuum-tight welding; - soft and hard soldering; - mechanical works including precision engineering; - plastics treatment - machining and polishing using diamond milling, modelling, lamination of various shapes and materials, including plexiglas, scintillators and light-guides; - painting - paint spraying with possibility of using furnace-fred drier of internal dimensions of 800 mm x 800 mm x 800 mm. Our workshop posses CNC milling machine which can be used for machining of work-pieces up to 500 kg

  16. Substoichiometric neutron activation determination of gold

    International Nuclear Information System (INIS)

    Mitchell, J.W.; Riley, J.E. Jr.; Payne, V.

    1978-01-01

    A highly precise and selective method is described for the determination of traces of gold by substoichiometric extraction from hydrochloric acid with tri-n-octylphosphine sulfide in cyclohexane following thermal neutron activation. Fundamental aspects of the extraction system are discussed and results are reported for the determination of gold in an effluent from a recovery process containing a complexed species of gold and unknown amounts of cyanide, citrate, phosphate, potassium and sodium. Other constituents of the effluent stream include traces of the transition elements Co, Ni, Fe, Cu, Zn, Pb and Sn at concentrations less than 50 ppm. One hour was allowed for the Au 3+ carrier and the 198 Au complexed species in samples and standards to oxidize, exchange, and reach chemical equilibrium. Samples were then equilibrated by shaking with the organic phase for thirty min. The percentage extractions (%E) for the substoichiometric separation of gold from the effluent and from the corresponding comparison standards were monitored. The mean percentage extractions for the substoichiometric separations of carrier from the effluent, and its corresponding standard were 75.3 and 59.3, respectively. These data are estimated to be accurate within +-2.0%. (T.G.)

  17. Special Equipment and/or Devices.

    Science.gov (United States)

    National Sanitation Foundation, Ann Arbor, MI.

    This standard covers the sanitation requirements for equipment and/or devices used in the storage, preparation, or handling of foods and beverages. The National Sanitation Foundation's basic criteria for the evaluation of special equipment and/or devices has been prepared to fulfill several specific needs, its major function being to serve as a…

  18. Biosynthesis of gold nanoparticles using diatoms-silica-gold and EPS-gold bionanocomposite formation

    OpenAIRE

    Schröfel, Adam; Kratošová, Gabriela; Bohunická, Markéta; Dobročka, Edmund; Vávra, Ivo

    2011-01-01

    Novel synthesis of gold nanoparticles, EPS-gold, and silica-gold bionanocomposites by biologically driven processes employing two diatom strains (Navicula atomus, Diadesmis gallica) is described. Transmission electron microscopy (TEM) and electron diffraction analysis (SAED) revealed a presence of gold nanoparticles in the experimental solutions of the diatom culture mixed with tetrachloroaureate. Nature of the gold nanoparticles was confirmed by X-ray diffraction studies. Scanning electron m...

  19. 7 CFR 58.626 - Packaging equipment.

    Science.gov (United States)

    2010-01-01

    ... containers with frozen desserts shall be constructed so that all product contact surfaces shall be of... Standards for Equipment for Packaging Frozen Desserts and Cottage Cheese. Quality Specifications for Raw...

  20. Ethical home medical equipment business practices.

    Science.gov (United States)

    Parver, C

    1991-11-01

    National uniform standards as a condition for receipt of a Medicare provider number would help rid the home medical equipment industry of those unethical and unscrupulous suppliers who have tarnished the industry's reputation.

  1. As duas vias do princípio das vantagens comparativas de David Ricardo e o padrão-ouro: um ensaio crítico The two ways of Ricardo's principle of comparative advantages and the gold standard: a critical essay

    Directory of Open Access Journals (Sweden)

    Cláudio Gontijo

    2007-09-01

    Full Text Available This article critically resumes Ricardo's principle of comparative advantages pointing out internal coherence problems that have been neglected by the specialized literature. First, long-lasting disequilibria observed in the balance of trade seem incompatible with the idea that these disequilibria are caused by technical advances that change relative prices. Second, comparative advantages do not seem to work in an economy with a universally accepted commodity-money. Finally, the contradiction between the gold standard mechanisms, ruled by Smith's "Law of Reflux", and the quantitative theory of money, which is a necessary condition for the "second way" of the theory of comparative advantages.

  2. Shipboard and laboratory equipment

    Digital Repository Service at National Institute of Oceanography (India)

    Shyamprasad, M.; Ramaswamy, V.

    The polymetallic nodules occur at an average depth of 4500 m. Adequate equipment and techniques are required for the exploration at such depths. Shipboard and various laboratory equipments for the sampling of polymetallic nodules is described...

  3. Remote handling equipment

    International Nuclear Information System (INIS)

    Clement, G.

    1984-01-01

    After a definition of intervention, problems encountered for working in an adverse environment are briefly analyzed for development of various remote handling equipments. Some examples of existing equipments are given [fr

  4. Exercise Equipment: Neutral Buoyancy

    Science.gov (United States)

    Shackelford, Linda; Valle, Paul

    2016-01-01

    Load Bearing Equipment for Neutral Buoyancy (LBE-NB) is an exercise frame that holds two exercising subjects in position as they apply counter forces to each other for lower extremity and spine loading resistance exercises. Resistance exercise prevents bone loss on ISS, but the ISS equipment is too massive for use in exploration craft. Integrating the human into the load directing, load generating, and motion control functions of the exercise equipment generates safe exercise loads with less equipment mass and volume.

  5. BP volume reduction equipment

    International Nuclear Information System (INIS)

    Kitamura, Yoshinori; Muroo, Yoji; Hamanaka, Isao

    2003-01-01

    A new type of burnable poison (BP) volume reduction system is currently being developed. Many BP rods, a subcomponent of spent fuel assemblies are discharged from nuclear power reactors. This new system reduces the overall volume of BP rods. The main system consists of BP rod cutting equipment, equipment for the recovery of BP cut pieces, and special transport equipment for the cut rods. The equipment is all operated by hydraulic press cylinders in water to reduce operator exposure to radioactivity. (author)

  6. Cryogenic equipment; Materiel cryogenique

    Energy Technology Data Exchange (ETDEWEB)

    Leger, L; Javellaud, J; Caro, C; Gilguy, R; Testard, O

    1966-06-01

    The cryostats presented here were built from standard parts; this makes it possible to construct a great variety of apparatus at minimum cost. The liquid nitrogen and helium reservoirs were designed so as to reduce losses to a minimum, and so as to make the cryostats as autonomous as possible. The experimental enclosure which is generally placed in the lower part of the apparatus requires a separate study in every case. Furthermore, complete assemblies such as transfer rods, isolated traps and high vacuum valves, were designed with a similar regard for the economic aspects and for the need for standardization. This equipment thus satisfies a great variety of experimental needs; it is readily adaptable and the consumptions of helium and liquid nitrogen are very low. (authors) [French] De nombreuses experiences utilisant les basses temperatures, necessitent l'emploi d'un materiel cryogenique complexe n'existant pas dans le commerce. Les cryostats presentes ici ont ete realises a partir d'elements standard, ce qui permet, malgre la diversite des appareils, de realiser un ensemble a moindre frais. Les reservoirs d'azote et d'helium liquides ont ete concus de facon a limiter les pertes et a conferer au cryostat la plus grande autonomie possible. L'enceinte experimentale situee en general dans la partie inferieure de l'appareil necessite dans tous les cas une etude speciale. D'autre part des ensembles complets tels que les cannes de transfert, piege isole, robinet pour vide secondaire, ont ete concus dans le meme souci de rentabilite et de standardisation. Ce materiel peut donc repondre a un grand nombre d'exigences experimentales, il est facilement adaptable, et les consommations d'helium et d'azote liquide sont tres reduites. (auteurs)

  7. Terminalia chebula mediated green and rapid synthesis of gold nanoparticles

    Science.gov (United States)

    Mohan Kumar, Kesarla; Mandal, Badal Kumar; Sinha, Madhulika; Krishnakumar, Varadhan

    2012-02-01

    Biologically inspired experimental process in synthesising nanoparticles is of great interest in present scenario. Biosynthesis of nanoparticles is considered to be one of the best green techniques in synthesising metal nanoparticles. Here, an in situ green biogenic synthesis of gold nanoparticles using aqueous extracts of Terminalia chebula as reducing and stabilizing agent is reported. Gold nanoparticles were confirmed by surface plasmon resonance in the range of 535 nm using UV-visible spectrometry. TEM analysis revealed that the morphology of the particles thus formed contains anisotropic gold nanoparticles with size ranging from 6 to 60 nm. Hydrolysable tannins present in the extract of T. chebula are responsible for reductions and stabilization of gold nanoparticles. Antimicrobial activity of gold nanoparticles showed better activity towards gram positive S. aureus compared to gram negative E. coli using standard well diffusion method.

  8. Characterisation of a thiosulphate-sulphite gold electrodeposition process

    International Nuclear Information System (INIS)

    J-Liew, M.; Sobri, S.; Roy, S.

    2005-01-01

    Electrodeposition of soft gold is an important process in the fabrication of micro devices for electronics, optics etc. Traditional gold electroplating is based on a gold cyanide process which is not applicable for the stringent requirements in state of the art micro device manufacture. Newcastle University has been involved in the development of an industrial process based on a mixed ligand electrolyte-the gold thiosulphate-sulphite system. Here we present methods for the formulation of this electrolyte in the laboratory which ensure bath stability and process compatibility. In addition, we have carried out spectrophotometry to elucidate the possible reasons of its chemical stability. Standard rotating disk and cyclic voltammetry has been carried out to determine the electrochemical behaviour of the gold thiosulphate-sulphite system. The changes in electrochemical behaviour as the bath ages are also discussed

  9. Equipment Leaks of Volatile Organic Compounds From Onshore Natural Gas Processing Plants for Which Construction, Reconstruction, or Modification Commenced After January 20, 1984, and on or Before August 23, 2011: New Source Performance Standards (NSPS)

    Science.gov (United States)

    Learn about the NSPS regulation for equipment leaks of Volatile Organic Compounds (VOC) from onshore natural gas processing plants by reading the rule summary, rule history, federal register citations, and the code of federal regulations

  10. GOLD IS EARNED FROM THE PRODUCTION OF THAI GOLD LEAF

    Directory of Open Access Journals (Sweden)

    Dirk Bax

    2010-06-01

    Full Text Available Thai people like to cover sacred objects or things dear to them with gold leaf.. Statues of Buddha are sometimes covered with so many layers of gold leaf that they become formless figures, that can hardly be recognized. Portraits of beloved ancestors, statues of elephants and grave tombs are often covered with gold leaf. If one considers the number of Thai people and the popularity of the habit, the amount of gold involved could be considerable.

  11. Fiscal 2000 project for development of international standards for supporting novel industries. Standardization of digital image processing for domestic digital electronic equipment; 2000 nendo shinki sangyo shiengata kokusai hyojun kaihatsu jigyo. Kateiyo digital denshi kiki ni okeru digital gazo shori no hyojunka

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Three-year research and development had been under way since fiscal 1998 for the establishment of global standards for domestic digital electronic equipment. In this last fiscal year of the project, emphasis was placed on supporting Japanese corporations concerned so that they would submit propositions relative to an expanded IPMP (Intellectual Property Management and Protection) system. First, Japan's technical propositions as to how to assure interchangeability between terminal devices were reviewed. Next, reviews were made of technical propositions and propositions for their application involving interface conversion and protocol conversion at content servers and RA servers, functional augmentation of roaming service, and the like. Support was provided for activities aiming at their global-scale standardization and for the preparation of groundwork materials for persons concerned with the technical committee involved. In relation to verification tests for supporting this project, system models, simulation models, and the like, were constructed. In relation to WD3.0 of IPMP, Japan's propositions were incorporated into its core, and this proved to be the major accomplishment under this project. (NEDO)

  12. Fiscal 2000 project for development of international standards for supporting novel industries. Standardization of digital image processing for domestic digital electronic equipment; 2000 nendo shinki sangyo shiengata kokusai hyojun kaihatsu jigyo. Kateiyo digital denshi kiki ni okeru digital gazo shori no hyojunka

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Three-year research and development had been under way since fiscal 1998 for the establishment of global standards for domestic digital electronic equipment. In this last fiscal year of the project, emphasis was placed on supporting Japanese corporations concerned so that they would submit propositions relative to an expanded IPMP (Intellectual Property Management and Protection) system. First, Japan's technical propositions as to how to assure interchangeability between terminal devices were reviewed. Next, reviews were made of technical propositions and propositions for their application involving interface conversion and protocol conversion at content servers and RA servers, functional augmentation of roaming service, and the like. Support was provided for activities aiming at their global-scale standardization and for the preparation of groundwork materials for persons concerned with the technical committee involved. In relation to verification tests for supporting this project, system models, simulation models, and the like, were constructed. In relation to WD3.0 of IPMP, Japan's propositions were incorporated into its core, and this proved to be the major accomplishment under this project. (NEDO)

  13. Functional gold nanoparticles for optical affinity biosensing

    Czech Academy of Sciences Publication Activity Database

    Špringer, Tomáš; Chadtová Song, Xue; Ermini, Maria Laura; Lamačová, Josefína; Homola, Jiří

    2017-01-01

    Roč. 409, č. 16 (2017), s. 4087-4097 ISSN 1618-2642 R&D Projects: GA ČR(CZ) GBP205/12/G118 Grant - others:AV ČR(CZ) AP1101 Program:Akademická prémie - Praemium Academiae Institutional support: RVO:67985882 Keywords : Gold nanoparticles * Cancer marker carcinoembryonic antigen * Surface plasmon resonance Subject RIV: FS - Medical Facilities ; Equipment OBOR OECD: Medical laboratory technology (including laboratory samples analysis Impact factor: 3.431, year: 2016

  14. Introduction of Mercury-free Gold Extraction Methods to Medium-Scale Miners and Education of Health Care Providers to Reduce the use of Mercury in Sorata, Bolivia

    Directory of Open Access Journals (Sweden)

    Peter W. U. Appel

    2015-01-01

    Conclusions. The gold ores tested during the project proved amenable to mercury-free gold extraction using borax smelting. The miners also realized that gold recovery increased when performing mercury-free gold extraction. The miners decided to stop using mercury and a follow-up project cleaned their mining equipment for mercury and modified the processing lines. The health care providers were also successfully trained.

  15. Gold film with gold nitride - A conductor but harder than gold

    International Nuclear Information System (INIS)

    Siller, L.; Peltekis, N.; Krishnamurthy, S.; Chao, Y.; Bull, S.J.; Hunt, M.R.C.

    2005-01-01

    The formation of surface nitrides on gold films is a particularly attractive proposition, addressing the need to produce harder, but still conductive, gold coatings which reduce wear but avoid the pollution associated with conventional additives. Here we report production of large area gold nitride films on silicon substrates, using reactive ion sputtering and plasma etching, without the need for ultrahigh vacuum. Nanoindentation data show that gold nitride films have a hardness ∼50% greater than that of pure gold. These results are important for large-scale applications of gold nitride in coatings and electronics

  16. Activated carbons and gold

    International Nuclear Information System (INIS)

    McDougall, G.J.; Hancock, R.D.

    1980-01-01

    The literature on activated carbon is reviewed so as to provide a general background with respect to the effect of source material and activation procedure on carbon properties, the structure and chemical nature of the surface of the activated carbon, and the nature of absorption processes on carbon. The various theories on the absorption of gold and silver from cyanide solutions are then reviewed, followed by a discussion of processes for the recovery of gold and silver from cyanide solutions using activated carbon, including a comparison with zinc precipitation

  17. Renewal of radiological equipment.

    Science.gov (United States)

    2014-10-01

    In this century, medical imaging is at the heart of medical practice. Besides providing fast and accurate diagnosis, advances in radiology equipment offer new and previously non-existing options for treatment guidance with quite low morbidity, resulting in the improvement of health outcomes and quality of life for the patients. Although rapid technological development created new medical imaging modalities and methods, the same progress speed resulted in accelerated technical and functional obsolescence of the same medical imaging equipment, consequently creating a need for renewal. Older equipment has a high risk of failures and breakdowns, which might cause delays in diagnosis and treatment of the patient, and safety problems both for the patient and the medical staff. The European Society of Radiology is promoting the use of up-to-date equipment, especially in the context of the EuroSafe Imaging Campaign, as the use of up-to-date equipment will improve quality and safety in medical imaging. Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or renewal. This plan should look forward a minimum of 5 years, with annual updates. Teaching points • Radiological equipment has a definite life cycle span, resulting in unavoidable breakdown and decrease or loss of image quality which renders equipment useless after a certain time period.• Equipment older than 10 years is no longer state-of-the art equipment and replacement is essential. Operating costs of older equipment will be high when compared with new equipment, and sometimes maintenance will be impossible if no spare parts are available.• Older equipment has a high risk of failure and breakdown, causing delays in diagnosis and treatment of the patient and safety problems both for the patient and the medical staff.• Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or replacement. This plan should look forward a

  18. Basic electrochemical properties of sputtered gold film electrodes

    International Nuclear Information System (INIS)

    Libansky, Milan; Zima, Jiri; Barek, Jiri; Reznickova, Alena; Svorcik, Vaclav; Dejmkova, Hana

    2017-01-01

    Gold nanolayers made by sputtering of pure gold (physical vapour deposition) are commonly used for many biophysical and material applications. However, the use of sputtering method for fabrication of working electrodes for electroanalytical purposes is less common. This paper focuses on the testing and characterization of sputtered working roughened gold nanostructured film electrodes, which fall into category of upcoming desirable new generation of nanostructured gold working electrodes. Gold nanostructured films (80 nm thin) were sputtered onto 50 μm thin PTFE substrates with three different types of treatment: pristine, plasma treated, and plasma treated and subsequently spontaneously grafted with biphenyl-4,4′-dithiol. The characterization of gold nanostructured film electrodes was carried out by examination of the electrode reaction of standard redox probes (ferrocyanide/ferricyanide, hydroquinone/benzoquinone) in different types of supporting electrolytes (BR buffers of various pH, KCl, KNO 3 , H 2 SO 4 ), by exploration of the electrode surface by scanning electron microscopy, by atomic force microscopy accompanied by elementary analysis and contact angle measurements. The testing of electrodes was complemented by an attempt to calculate their real surface areas from Randles-Sevcik equation. All results were compared to conventional bulk gold electrode. The practical applicability of the nanostructured gold electrodes as sensors for the determination of environmental pollutants was verified by voltammetric determination of hydroquinone as a model electrochemically oxidisable organic environmental pollutant.

  19. Hallmarking as an essential need of gold industry

    International Nuclear Information System (INIS)

    Mahmood, K.; Alam, S.; Ahmed, T.

    2006-01-01

    As gold is a soft metal, for Jewellery making it is alloyed with Silver or Copper so that its strength may increase. Other main alloying elements include; Zinc, Cadmium and Nickel. These alloying elements help to reduce cost, improve appearance and to improve chemical properties of gold. The percentage of alloying elements determines the caratages of gold. The gold Jewellery sold in local market is often under-carated. In order to improve the quality of product sold, complete quality assessment of gold should be done. A complete quality assessment includes both Assaying and Hallmarking. Assaying is the analysis of an individual sample of gold from a customer to find out it's composition and Hallmarking refers to physically marking: a piece of Jewellery according to specific laws to certify the purity of metal. In this paper we have assessed and compared the quality of locally manufactured gold ornaments and its alloying components with international market as well as standards of gold and its alloys. And as Hallmarking is one of the main strategic initiatives to improve the quality of product sold for domestic and export consumption, this paper discusses the necessary steps leading to Hallmarking. We have used micro-XRF spectrometer for assaying and Laser Engraving machine for the purpose of Hallmarking. (author)

  20. Disinfection protocols for necropsy equipment in rabies laboratories: Safety of personnel and diagnostic outcome.

    Science.gov (United States)

    Aiello, Roberta; Zecchin, Barbara; Tiozzo Caenazzo, Silvia; Cattoli, Giovanni; De Benedictis, Paola

    2016-08-01

    In the last decades, molecular techniques have gradually been adopted for the rapid confirmation of results obtained through gold standard methods. However, international organisations discourage their use in routine laboratory investigations for rabies post-mortem diagnosis, as they may lead to false positive results due to cross-contamination. Cleaning and disinfection are essential to prevent cross-contamination of samples in the laboratory environment. The present study evaluated the efficacy of selected disinfectants on rabies-contaminated necropsy equipment under organic challenge using a carrier-based test. The occurrence of detectable Rabies virus (RABV) antigen, viable virus and RNA was assessed through the gold standard Fluorescent Antibody Test, the Rabies Tissue Culture Infection Test and molecular techniques, respectively. None of the tested disinfectants proved to be effective under label conditions. Off label disinfection protocols were found effective for oxidizing agents and phenolic, only. Biguanide and quaternary ammonium compound were both ineffective under all tested conditions. Overall, discordant results were obtained when different diagnostic tests were compared, which means that in the presence of organic contamination common disinfectants may not be effective enough on viable RABV or RNA. Our results indicate that an effective disinfection protocol should be carefully validated to guarantee staff safety and reliability of results. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  1. Spectroscopic diagnostic of gold plasma

    International Nuclear Information System (INIS)

    Busquet, M.

    1986-01-01

    Results of a simulation of a gold-aluminium alloy target irradiated by laser are presented. FCI code has been used with a processing out of LTE of atomic physics of gold and of multigroup photonics. Emission and reabsorption of gold and aluminium lines are included [fr

  2. Spectroscopic diagnostic of gold plasma

    Energy Technology Data Exchange (ETDEWEB)

    Busquet, M.

    1986-06-01

    Results of a simulation of a gold-aluminium alloy target irradiated by laser are presented. FCI code has been used with a processing out of LTE of atomic physics of gold and of multigroup photonics. Emission and reabsorption of gold and aluminium lines are included.

  3. Establishment for Nuclear Equipment: Overview

    International Nuclear Information System (INIS)

    Pracz, J.

    2001-01-01

    Full text: The activity of ZdAJ in 2000 was focused on realisation of the Government-Ordered Project - 6/15 MeV Accelerator. The realisation was accomplished in two stages: - stage I should result in deriving principal operational parameters of the accelerator - stage 2 will result in full implementation of the control system providing optimum control of the equipment and automatic maintaining of its parameters. Within the frames of the first stage, a klystron modulator panel was finished and the design documentation of the mechanical supporting structure, the arm, accelerating structure, collimator and control panel were advanced. Manufacturing of the above sub-units in the workshop has started. In the frames of the Specific Project of the State Committee for Scientific Research, the improvement of Neptun lOPC accelerator was undertaken. The read-out of the monitor dose with atmospheric pressure and ambient temperature compensation has been introduced. New filters for equalising the photon and electron beam and new wedge filters have been designed. Changes in programming have been introduced, which improve the patient's safety by eliminating possible personnel errors and increase the accuracy of radiation fields read-out. In 2000 ZdAJ progressed in development of the Quality System conforming EN-ISO 9001 Standard by including the provisions of EN 46001 Standard. The Standard EN 46001: ''Quality Systems - Medical Equipment''. Detailed requirements related to application of EN ISO 9001 is an European Quality Standard extending the provisions of EN ISO 9001 Standard over the manufacturers of medical equipment. (author)

  4. Gold Nanoparticle Microwave Synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Krantz, Kelsie E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Christian, Jonathan H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Coopersmith, Kaitlin [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Washington, II, Aaron L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Murph, Simona H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-07-27

    At the nanometer scale, numerous compounds display different properties than those found in bulk material that can prove useful in areas such as medicinal chemistry. Gold nanoparticles, for example, display promise in newly developed hyperthermia therapies for cancer treatment. Currently, gold nanoparticle synthesis is performed via the hot injection technique which has large variability in final particle size and a longer reaction time. One underdeveloped area by which these particles could be produced is through microwave synthesis. To initiate heating, microwaves agitate polar molecules creating a vibration that gives off the heat energy needed. Previous studies have used microwaves for gold nanoparticle synthesis; however, polar solvents were used that partially absorbed incident microwaves, leading to partial thermal heating of the sample rather than taking full advantage of the microwave to solely heat the gold nanoparticle precursors in a non-polar solution. Through this project, microwaves were utilized as the sole heat source, and non-polar solvents were used to explore the effects of microwave heating only as pertains to the precursor material. Our findings show that the use of non-polar solvents allows for more rapid heating as compared to polar solvents, and a reduction in reaction time from 10 minutes to 1 minute; this maximizes the efficiency of the reaction, and allows for reproducibility in the size/shape of the fabricated nanoparticles.

  5. Bioassisted Phytomining of Gold

    Science.gov (United States)

    Maluckov, Biljana S.

    2015-05-01

    Bioassisted phytomining implies targeted use of microorganisms and plants for the selective recovery of the metal. Metals from undissolved compounds are dissolved by applying specially chosen microorganisms and therefore become available to the hyperaccumulating plants. In the article, the selective extraction method of base metals and the precious metal gold by using microorganisms and plants is discussed.

  6. Digging for Gold

    Science.gov (United States)

    Waters, John K.

    2012-01-01

    In the case of higher education, the hills are more like mountains of data that "we're accumulating at a ferocious rate," according to Gerry McCartney, CIO of Purdue University (Indiana). "Every higher education institution has this data, but it just sits there like gold in the ground," complains McCartney. Big Data and the new tools people are…

  7. GOLD PRESSURE VESSEL SEAL

    Science.gov (United States)

    Smith, A.E.

    1963-11-26

    An improved seal between the piston and die member of a piston-cylinder type pressure vessel is presented. A layer of gold, of sufficient thickness to provide an interference fit between the piston and die member, is plated on the contacting surface of at least one of the members. (AEC)

  8. Gold Nanoparticle Microwave Synthesis

    International Nuclear Information System (INIS)

    Krantz, Kelsie E.; Christian, Jonathan H.; Coopersmith, Kaitlin; Washington II, Aaron L.; Murph, Simona H.

    2016-01-01

    At the nanometer scale, numerous compounds display different properties than those found in bulk material that can prove useful in areas such as medicinal chemistry. Gold nanoparticles, for example, display promise in newly developed hyperthermia therapies for cancer treatment. Currently, gold nanoparticle synthesis is performed via the hot injection technique which has large variability in final particle size and a longer reaction time. One underdeveloped area by which these particles could be produced is through microwave synthesis. To initiate heating, microwaves agitate polar molecules creating a vibration that gives off the heat energy needed. Previous studies have used microwaves for gold nanoparticle synthesis; however, polar solvents were used that partially absorbed incident microwaves, leading to partial thermal heating of the sample rather than taking full advantage of the microwave to solely heat the gold nanoparticle precursors in a non-polar solution. Through this project, microwaves were utilized as the sole heat source, and non-polar solvents were used to explore the effects of microwave heating only as pertains to the precursor material. Our findings show that the use of non-polar solvents allows for more rapid heating as compared to polar solvents, and a reduction in reaction time from 10 minutes to 1 minute; this maximizes the efficiency of the reaction, and allows for reproducibility in the size/shape of the fabricated nanoparticles.

  9. Gold and gold working in Late Bronze Age Northern Greece

    Science.gov (United States)

    Vavelidis, M.; Andreou, S.

    2008-04-01

    Numerous objects of gold displaying an impressive variety of types and manufacturing techniques are known from the Late Bronze Age (LBA) contexts of Mycenaean Greece, but very little is known about the origin and processing of gold during the second millennium b.c. Ancient literature and recent research indicate that northern Greece is probably the richest gold-bearing region in Greece, and yet, very little evidence exists regarding the exploitation of its deposits and the production as well as use of gold in the area during prehistory. The unusual find of a group of small stone crucibles at the prehistoric settlement of Thessaloniki Toumba, one with visible traces of gold melting, proves local production and offers a rare opportunity to examine the process of on-site gold working. Furthermore, the comparison of the chemical composition of prehistoric artefacts from two settlements with those of gold deposits in their immediate areas supports the local extraction of gold and opens up the prospect for some of the Mycenaean gold to have originated in northern Greece. The scarcity of gold items in northern Greek LBA contexts may not represent the actual amount of gold produced and consumed, but could be a result of the local social attitudes towards the circulation and deposition of artefacts from precious metals.

  10. Quantitative electrical detection of immobilized protein using gold nanoparticles and gold enhancement on a biochip

    International Nuclear Information System (INIS)

    Lei, Kin Fong

    2011-01-01

    Electrical detection of the concentration of protein immobilized on a biochip is demonstrated. The concentration of the direct immobilized protein can be determined by the resistance values measured by an ohm-meter directly. Indium tin oxide interdigitated electrodes were utilized as the detection sites on the biochip. Protein, i.e. antibody, of certain concentration was first immobilized on the detection site. Gold nanoparticles were then applied to indicate the immobilized protein. Since the gold nanoparticles were tiny, a detectable electrical signal could not be generated. Hence, a gold enhancement process was performed for signal amplification. Gold nanoparticles were enlarged physically, such that a conductive metal layer was formed on the detection site. The presence and concentration of protein can be determined by the resistance value across the electrode measured by an ohm-meter. An immobilized protein concentration ranging from 50 to 1000 ng ml −1 can be detected quantitatively by the resistance values from 4300 to 1700 Ω. The proposed technique is potentially extended for the detection of immunoassay on the biochip. Since the protocol of the electrical detection does not involve sophisticated equipment, it can therefore be used for the development of a portable immunoassay device

  11. RETRIEVAL EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    J. Steinhoff

    1997-01-01

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) retrieval from the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. There are no quality assurance requirements or QA controls in this document. Retrieval under normal conditions is accomplished with the same fleet of equipment as is used for emplacement. Descriptions of equipment used for retrieval under normal conditions is found in Emplacement Equipment Descriptions, DI: BCAF00000-01717-5705-00002 (a document in progress). Equipment used for retrieval under abnormal conditions is addressed in this document and consists of the following: (1) Inclined Plane Hauler; (2) Bottom Lift Transporter; (3) Load Haul Dump (LHD) Loader; (4) Heavy Duty Forklift for Emplacement Drifts; (5) Covered Shuttle Car; (6) Multipurpose Vehicle; and (7) Scaler

  12. Pre-Columbian alloys from the royal tombs of Sipan; energy dispersive X-ray fluorescence analysis with a portable equipment

    Energy Technology Data Exchange (ETDEWEB)

    Cesareo, R. [Dip. di Matematica e Fisica, Universita di Sassari, via Vienna 2, 07100, Sassari (Italy)], E-mail: cesareo@uniss.it; Calza, C.; Dos Anjos, M.; Lopes, R.T. [Nuclear Instrumentation Laboratory, COPPE, Universidade Federal do Rio de Janeiro (Brazil); Bustamante, A.; Fabian S, J. [Universidad Nacional Mayor de San Marcos, Lima (Peru); Alva, W.; Chero Z, L. [Museo ' Tumbas Reales de Sipan' , Lambayeque (Peru)

    2010-04-15

    On the north coast of present-day Peru flourished approximately between 50 and 700 AD, the Moche civilization. It was an advanced culture and the Moche were sophisticated metalsmiths, so that they are considered as the finest producers of jewels and artefacts of the region. The Moche metalworking ability was impressively demonstrated by the objects discovered by Walter Alva and coworkers in 1987, in the excavations of the 'Tumbas Reales de Sipan'. About 50 metal objects from these excavations, now at the namesake Museum, in Lambayeque, north of Peru, were analyzed with a portable equipment using energy-dispersive X-ray fluorescence. This portable equipment is mainly composed of a small size X-ray tube and a thermoelectrically cooled X-ray detector. Standard samples of gold and silver alloys were employed for quantitative analysis. It was determined that the analyzed artefacts from the 'Tumbas Reales de Sipan' are mainly composed of gold, silver and copper alloys, of gilded copper and of tumbaga, the last being a poor gold alloy enriched at the surface by depletion gilding, i.e. removing copper from the surface.

  13. Pre-Columbian alloys from the royal tombs of Sipan; energy dispersive X-ray fluorescence analysis with a portable equipment

    International Nuclear Information System (INIS)

    Cesareo, R.; Calza, C.; Dos Anjos, M.; Lopes, R.T.; Bustamante, A.; Fabian S, J.; Alva, W.; Chero Z, L.

    2010-01-01

    On the north coast of present-day Peru flourished approximately between 50 and 700 AD, the Moche civilization. It was an advanced culture and the Moche were sophisticated metalsmiths, so that they are considered as the finest producers of jewels and artefacts of the region. The Moche metalworking ability was impressively demonstrated by the objects discovered by Walter Alva and coworkers in 1987, in the excavations of the 'Tumbas Reales de Sipan'. About 50 metal objects from these excavations, now at the namesake Museum, in Lambayeque, north of Peru, were analyzed with a portable equipment using energy-dispersive X-ray fluorescence. This portable equipment is mainly composed of a small size X-ray tube and a thermoelectrically cooled X-ray detector. Standard samples of gold and silver alloys were employed for quantitative analysis. It was determined that the analyzed artefacts from the 'Tumbas Reales de Sipan' are mainly composed of gold, silver and copper alloys, of gilded copper and of tumbaga, the last being a poor gold alloy enriched at the surface by depletion gilding, i.e. removing copper from the surface.

  14. Pre-Columbian alloys from the royal tombs of Sipán; energy dispersive X-ray fluorescence analysis with a portable equipment.

    Science.gov (United States)

    Cesareo, R; Calza, C; Dos Anjos, M; Lopes, R T; Bustamante, A; Fabian S, J; Alva, W; Chero Z, L

    2010-01-01

    On the north coast of present-day Peru flourished approximately between 50 and 700 AD, the Moche civilization. It was an advanced culture and the Moche were sophisticated metalsmiths, so that they are considered as the finest producers of jewels and artefacts of the region. The Moche metalworking ability was impressively demonstrated by the objects discovered by Walter Alva and coworkers in 1987, in the excavations of the "Tumbas Reales de Sipán". About 50 metal objects from these excavations, now at the namesake Museum, in Lambayeque, north of Peru, were analyzed with a portable equipment using energy-dispersive X-ray fluorescence. This portable equipment is mainly composed of a small size X-ray tube and a thermoelectrically cooled X-ray detector. Standard samples of gold and silver alloys were employed for quantitative analysis. It was determined that the analyzed artefacts from the "Tumbas Reales de Sipán" are mainly composed of gold, silver and copper alloys, of gilded copper and of tumbaga, the last being a poor gold alloy enriched at the surface by depletion gilding, i.e. removing copper from the surface. Copyright 2009 Elsevier Ltd. All rights reserved.

  15. Diagnostic imaging and radiation therapy equipment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-05-01

    This is the third edition of CSA Standard C22.2 No. 114 (now CAN/CSA-C22.2 No. 114), which is one of a series of standards issued by the Canadian Standards Association under Part II of the Canadian Electrical Code. This edition marks an important shift towards harmonization of Canadian requirements with those of the European community and the United States. Also important to this edition is the expansion of its scope to include the complete range of diagnostic imaging and radiation therapy equipment, rather than solely radiation-emitting equipment. In so doing, equipment previously addressed by CSA Standard C22.2 No. 125, Electromedical Equipment, specifically lasers for medical applications and diagnostic ultrasound units, is now dealt with in the new edition. By virtue of this expanded scope, many of the technical requirements in the electromedical equipment standard have been introduced to the new edition, thereby bringing CSA Standard C22.2 No. 114 up to date. 14 tabs., 16 figs.

  16. Diagnostic imaging and radiation therapy equipment

    International Nuclear Information System (INIS)

    1990-05-01

    This is the third edition of CSA Standard C22.2 No. 114 (now CAN/CSA-C22.2 No. 114), which is one of a series of standards issued by the Canadian Standards Association under Part II of the Canadian Electrical Code. This edition marks an important shift towards harmonization of Canadian requirements with those of the European community and the United States. Also important to this edition is the expansion of its scope to include the complete range of diagnostic imaging and radiation therapy equipment, rather than solely radiation-emitting equipment. In so doing, equipment previously addressed by CSA Standard C22.2 No. 125, Electromedical Equipment, specifically lasers for medical applications and diagnostic ultrasound units, is now dealt with in the new edition. By virtue of this expanded scope, many of the technical requirements in the electromedical equipment standard have been introduced to the new edition, thereby bringing CSA Standard C22.2 No. 114 up to date. 14 tabs., 16 figs

  17. Medical equipment management

    CERN Document Server

    Willson, Keith; Tabakov, Slavik

    2013-01-01

    Know What to Expect When Managing Medical Equipment and Healthcare Technology in Your Organization As medical technology in clinical care becomes more complex, clinical professionals and support staff must know how to keep patients safe and equipment working in the clinical environment. Accessible to all healthcare professionals and managers, Medical Equipment Management presents an integrated approach to managing medical equipment in healthcare organizations. The book explains the underlying principles and requirements and raises awareness of what needs to be done and what questions to ask. I

  18. Data communication equipment

    International Nuclear Information System (INIS)

    Kim, Hak Seon; Lee, Sang Mok

    1998-02-01

    The contents of this book are introduction of data communication on definition, purpose and history, information terminal about data communication system and data transmission system, data transmit equipment of summary, transmission cable, data port, concentrator and front-end processor, audio communication equipment like phones, radio communication equipment of summary on foundation of electromagnetic waves, AM transmitter, AM receiver, FM receiver and FM transmitter, a satellite and mobile communication equipment such as earth station, TT and C and Cellular phone, video telephone and new media apparatus.

  19. Moessbauerspectroscopy on Gold Ruby Glass

    International Nuclear Information System (INIS)

    Haslbeck, S.

    2005-01-01

    In this thesis, the chemical states of gold and the physical mechanisms of the growing process of the particles under the influence of additional ingredients like tin, lead, antimony and selenium before, during and after the colouring process are investigated by using the Moessbauer spectroscopy on 197 Au, 119 Sn and 121 Sb, optical spectroscopy and X-ray-diffraction. Gold in an unnealed, colourless state of the glasses consists of monovalent forming linear bonds to two neighbouring oxygen atoms. The Lamb-Moessbauer factor of these gold oxide bondings is observed as 0.095 at 4.2 K. The gold in it's oxide state transforms to gold particles with a diameter of 3 nm to 60 nm. The size of the gold particles is quite definable within the optical spectra and certain sizes are also discernable within the Moessbauer spectra. One component of the Moessbauer spectra is assigned to the surface layer of the gold particles. By comparing this surface component with the amount of the bulk metallic core, one can calculate the size of the gold particles. In the Moessbauer spectra of the colourless glass one also can find parts of bulk metallic gold. Investigations with X-ray diffraction show that these are gold particles with a diameter of 100 nm to 300 nm and therefore have no additional colouring effect within the visible spectrum. The Moessbauer spectra on gold of the remelt glasses are similar to those which have been measured on the initial colourless glasses

  20. For the love of gold

    International Nuclear Information System (INIS)

    Young, J.E.

    1993-01-01

    Gold is found in minute quantities and gold mining generates enormous amounts of waste materials and long history of environmental destruction: mercury in tailing, eroded land, and acid mine drainage are legacies of the past. The problem has become worse in recent years in North America, Australia, the Amazon basin, Philippines. This paper describes the economics of gold and the changes in the world economy which has precipitated the new gold rushes. Current technology uses a cyanide solution for leaching small amounts of gold from tons of waste, and mercury remains a toxic waste of gold mining. Both short and long term results of gold mining, on the environment and on indiginous populations are described

  1. A comparative evaluation of drilling techniques for deposits containing free gold using radioactive gold particles as tracers

    International Nuclear Information System (INIS)

    Clarkson, R.

    1998-01-01

    In the summers of 1992 and 1994, the author designed and carried out a statistically valid research program using radioactivated gold particles as tracers (radiotracers). Two types of fully cased normal circulation (N / C) drills, two types of reverse circulation (R/C) drills and three solid auger drills were evaluated under a variety of field conditions. A frozen cylindrical core of compacted gravels containing four sizes ( 1.2, 0.60, 0.30 and 0.15 mm), (+l4,+28,+48and+100 mesh)of radiotracers was placed in 44 drill holes and the holes were re drilled. Scintillometers were used to track free gold losses due to spillage and blow-by around the collar (top) of the hole. Some gold particles were located in temporary traps in the drilling equipment and these particles would have contaminated subsequent samples (as carry-over). Several myths commonly attributed to particular drilling methods were dispelled. There was no significant difference between the recovery of the four sizes of gold particles with any of the drills tested. Observations and down-hole scintillometer records indicated that the free gold particles did not follow the bit down the hole and were either carried out of the hole or forced onto the sides of the hole at or above the depth at which the radioactive gold was positioned. A comparative evaluation of the results of these tests is presented

  2. A radiochemical study of gold electrodeposition kinetics in alkaline cyanide solutions

    International Nuclear Information System (INIS)

    Poshkus, D.; Agafonovas, G.; Zhebrauskas, A.

    1995-01-01

    Kinetics of gold electrodeposition from alkaline cyanide solutions was investigated by the use of labelled gold 195 atoms. The absorption of cyanide containing species from alkaline cyanide and dicyanoaurate solutions on a gold electrode by the use of labelled carbon atoms was investigated. Polarization curves of anodic dissolution and cathodic deposition of gold in alkaline cyanide solutions were obtained. The values of standard potential, exchange current density, transfer coefficient and standard polarization rate were determined from polarization curves. The errors in current density caused by the nuclear disintegration statistics were evaluated. 28 refs., 1 tab., 4 figs

  3. Anesthetic equipment, facilities and services available for pediatric ...

    African Journals Online (AJOL)

    2011-04-09

    Apr 9, 2011 ... standards and increased use of disposable anesthetic equipment. An audit of equipment and facilities for anesthetic care in pediatric patients is important and should be carried out periodically to appraise the situation for upgrading of essential anesthetic facilities and equipment. Appendix A. 18th March, ...

  4. Process and equipment design optimising product properties and attributes

    NARCIS (Netherlands)

    Bongers, P.M.M.; Thullie, J.

    2009-01-01

    Classically, when products have been developed at the bench, process engineers will search for equipment to manufacture the product at large scale. More than often, this search is constraint to the existing equipment base, or a catalog search for standard equipment. It is then not surprising, that

  5. 7 CFR 550.39 - Equipment replacement insurance.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Equipment replacement insurance. 550.39 Section 550.39... Agreements Equipment/property Standards § 550.39 Equipment replacement insurance. If required by the terms and conditions of the award, the Cooperator shall provide adequate insurance coverage for replacement...

  6. 40 CFR 63.1434 - Equipment leak provisions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Equipment leak provisions. 63.1434... Standards for Hazardous Air Pollutant Emissions for Polyether Polyols Production § 63.1434 Equipment leak provisions. (a) The owner or operator of each affected source shall comply with the HON equipment leak...

  7. 21 CFR 58.63 - Maintenance and calibration of equipment.

    Science.gov (United States)

    2010-04-01

    ... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Equipment § 58.63 Maintenance and... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Maintenance and calibration of equipment. 58.63..., maintenance, testing, calibration, and/or standardization of equipment, and shall specify, when appropriate...

  8. Reviews Book: SEP Communications: Transmitting and Receiving Signals Book: Gliding for Gold Book: Radioactivity: A History of a Mysterious Science Book: The New Quantum Age Books: The Art of Science and The Oxford Book of Modern Science Writing Equipment: SEP Analogue/digital transmission unit Equipment: SEP Optical signal transmission set Book: Stars and their Spectra Book: Voicebox: The Physics and Evolution of Speech Web Watch

    Science.gov (United States)

    2012-03-01

    WE RECOMMEND Transmitting and Receiving Signals SEP booklet transmits knowledge The New Quantum Age Understanding modern quantum theory The Art of Science and The Oxford Book of Modern Science Writing Anthologies bring science to life SEP Analogue/digital transmission unit Kit transmits signal between two points SEP Optical signal transmission set Optical kit shows light transmission Stars and their Spectra New book for teaching astrophysics WORTH A LOOK Gliding for Gold Take a journey through the physics of winter sports Radioactivity: A History of a Mysterious Science Book looks at history of radioactivity Voicebox: The Physics and Evolution of Speech TExploring the evolution of the voice WEB WATCH An interactive program with promise?

  9. Cooling of electronic equipment

    DEFF Research Database (Denmark)

    A. Kristensen, Anders Schmidt

    2003-01-01

    Cooling of electronic equipment is studied. The design size of electronic equipment decrease causing the thermal density to increase. This affect the cooling which can cause for example failures of critical components due to overheating or thermal induced stresses. Initially a pin fin heat sink...

  10. Capital Equipment Replacement Decisions

    OpenAIRE

    Batterham, Robert L.; Fraser, K.I.

    1995-01-01

    This paper reviews the literature on the optimal replacement of capital equipment, especially farm machinery. It also considers the influence of taxation and capital rationing on replacement decisions. It concludes that special taxation provisions such as accelerated depreciation and investment allowances are unlikely to greatly influence farmers' capital equipment replacement decisions in Australia.

  11. Rushing for gold

    DEFF Research Database (Denmark)

    Jønsson, Jesper Bosse; Bryceson, Deborah Fahy

    2009-01-01

    African rural dwellers have faced depressed economic prospects for several decades. Now, in a number of mineral-rich countries, multiple discoveries of gold and precious stones have attracted large numbers of prospective small-scale miners. While their 'rush' to, and activities within, mining sit...... affluent than the others, suggesting that movement can be rewarding for those willing to 'try their luck' with the hard work and social networking demands of mining another site.......African rural dwellers have faced depressed economic prospects for several decades. Now, in a number of mineral-rich countries, multiple discoveries of gold and precious stones have attracted large numbers of prospective small-scale miners. While their 'rush' to, and activities within, mining sites...

  12. Gold' 82 - technical sessions

    International Nuclear Information System (INIS)

    Viewing, K.

    1983-01-01

    Sulphur-isotope studies had been applied by Dr. I. Lambert to a number of deposits in Western Australia and also to certain samples from Vubachickwe and other deposits in Zimbabwe. A study of the sulphur isotopes at the Dickenson Mine, revealed a wide spread of values in the mineralised zones. Metamorphic processes were likely to be significant in the concentration of gold. The iron formations at the Old Jardine Mine had been unfolded by Dr. W.S. Hallager and the pattern of sedimentation was unraveled. A gold-rich zone was separated by a barren gap from the other part of the mineralised zone. Research was also done on the effects of the metamorphic processes, and the ages of mineralisation

  13. Radioactive gold ring dermatitis

    International Nuclear Information System (INIS)

    Miller, R.A.; Aldrich, J.E.

    1990-01-01

    A superficial squamous cell carcinoma developed in a woman who wore a radioactive gold ring for more than 30 years. Only part of the ring was radioactive. Radiation dose measurements indicated that the dose to basal skin layer was 2.4 Gy (240 rad) per week. If it is assumed that the woman continually wore her wedding ring for 37 years since purchase, she would have received a maximum dose of approximately 4600 Gy

  14. Establishment of nuclear equipment qualification system

    International Nuclear Information System (INIS)

    Joo, Po Kook; Lim, Nam Jin; Lee, Young Gun

    2003-04-01

    This study is carried out by KEARI(Korea Atomic Energy Research Institute) as the lead organization in cooperation with KIMM(Korea Institute of Machinery and Materials), KTL(Korea Testing Laboratory) and KRISS(Korea Research Institute of Standards and Science) to construct a basis of efficient management of nuclear equipment qualification business by expanding test equipment of each of participating organization, and developing qualification technologies. As for KIMM, control system of large scale shaker was replaced with advanced system, and LOCA(Loss of Coolant Accident) test facility was installed. KTL is now capable of conducting seismic tests of nuclear I and C as a result of installation of seismic test equipment during the first two project years. KRISS participated in the Project with a view to have large scale EMI test equipment and related technologies. In parallel with expansion of test equipment, a industrial-educational-research cooperation committee, as an intermediate step toward integrated equipment qualification system to maximize the usage of test equipment, was established and cooperation methods were investigated. As a result, Korea Nuclear Equipment Qualification Association, an corporate juridical person, was established. Research on development of thermal and radiation aging test technology of nuclear materials was carried out by Hanyang University and SECO(Saehan Engineering and Qualification Co., Ltd.). Integrated Equipment Qualification Database was developed which contains material test data, equipment qualification data and other EQ related informations. Standard qualification procedures were developed in order for test laboratories and manufacturers to establish design requirements and to efficiently perform tests

  15. Low-energy ED-XRF spectrometry application in gold assaying

    International Nuclear Information System (INIS)

    Marucco, Alessandra

    2004-01-01

    The performances of a low-energy dispersive XRF spectrometer in gold assaying are evaluated by a series of analysis on international standards and other certified gold alloys with. Results of standard-free analysis based on fundamental parameters method compared to results of multi-standard method, demonstrate a large gain of accuracy by drawing appropriate calibration curves with use of 1 to 16 matrix-specific standards. The accuracy of gold assaying has improved by a factor of 10, as compared to the conventional touchstone test. This rather economical technique satisfies then numerous precious alloys analyst needs, representing an excellent alternative to the traditional method for quick anti-fraud controls

  16. Electrical, Electronic, and Electromechanical (EEE) Parts Management and Control Requirements for Space Flight Hardware and Critical Ground Support Equipment...aka... The NASA EEE Parts Standard, NASA-STD 8739.10

    Science.gov (United States)

    Majewicz, Peter; Sampson, Michael

    2016-01-01

    Describes development and content of a new NASA Standard for Electrical Electronic and Electromechanical (EEE) parts. This Standard reflects current practices, instead of changing them. Most NASA Centers utilize local documents, but there is minimal consistency across the Agency. A gap analysis clearly shows the differences that exist among the different centers and with respect to the NASA Parts Policy. Once approved, the new standard can be referenced in contracts and agreements with organizations outside of NASA.

  17. Analysis of gold in jewellery articles by energy dispersive XRF

    International Nuclear Information System (INIS)

    Meor Yusoff Meor Sulaiman; Latifah Amin

    2001-01-01

    The value of a precious metal article is much related to its fineness. For gold assay, conventional fire assay technique has been used as the standard technique for more than 500 years. Alternative modern techniques like energy dispersive x-ray fluorescence can also be used in the determination of gold purity. Advantages of this technique compared to the conventional method including non-destructive analysis, does not use any toxic or hazardous chemicals, automatic computer control and is user friendly, requires minimum number of personnel, shorter analysis time and able to determine associated elements in the metal. Analysis was performed on different sizes and purity of gold. Comparison results for the analysis using different reference standards show small differences between technique and its certified value. The technique also gives small standard deviation value in its repeatability test. (Author)

  18. Nanomolar Trace Metal Analysis of Copper at Gold Microband Arrays

    Science.gov (United States)

    Wahl, A.; Dawson, K.; Sassiat, N.; Quinn, A. J.; O'Riordan, A.

    2011-08-01

    This paper describes the fabrication and electrochemical characterization of gold microband electrode arrays designated as a highly sensitive sensor for trace metal detection of copper in drinking water samples. Gold microband electrodes have been routinely fabricated by standard photolithographic methods. Electrochemical characterization were conducted in 0.1 M H2SO4 and found to display characteristic gold oxide formation and reduction peaks. The advantages of gold microband electrodes as trace metal sensors over currently used methods have been investigated by employing under potential deposition anodic stripping voltammetry (UPD-ASV) in Cu2+ nanomolar concentrations. Linear correlations were observed for increasing Cu2+ concentrations from which the concentration of an unknown sample of drinking water was estimated. The results obtained for the estimation of the unknown trace copper concentration in drinking was in good agreement with expected values.

  19. Nanomolar Trace Metal Analysis of Copper at Gold Microband Arrays

    International Nuclear Information System (INIS)

    Wahl, A; Dawson, K; Sassiat, N; Quinn, A J; O'Riordan, A

    2011-01-01

    This paper describes the fabrication and electrochemical characterization of gold microband electrode arrays designated as a highly sensitive sensor for trace metal detection of copper in drinking water samples. Gold microband electrodes have been routinely fabricated by standard photolithographic methods. Electrochemical characterization were conducted in 0.1 M H 2 SO 4 and found to display characteristic gold oxide formation and reduction peaks. The advantages of gold microband electrodes as trace metal sensors over currently used methods have been investigated by employing under potential deposition anodic stripping voltammetry (UPD-ASV) in Cu 2+ nanomolar concentrations. Linear correlations were observed for increasing Cu 2+ concentrations from which the concentration of an unknown sample of drinking water was estimated. The results obtained for the estimation of the unknown trace copper concentration in drinking was in good agreement with expected values.

  20. Radiochemical neutron activation analysis of gold in geochemical samples

    International Nuclear Information System (INIS)

    Zilliacus, R.

    1983-01-01

    A fast method for the radiochemical neutron activation analysis of gold in geochemical samples is described. The method is intended for samples having background concentrations of gold. The method is based on the dissolution of samples with hydrofluoric acid and aqua regia followed by the dissolution of the fluorides with boric acid and hydrochloric acid. Gold is then adsorbed on activated carbon by filtrating the solution through a thin carbon layer. The activity measurements are carried out using a Ge(Li)-detector and a multichannel analyzer. The chemical yields of the separation determined by reirradiation vary between 60 and 90%. The detection limit of the method is 0.2 ng/g gold in rock samples. USGS standard rocks and exploration reference materials are analyzed and the results are presented and compared with literature data. (author)

  1. Mercury use in small scale gold mining in Ghana: an assessment of its impact on miners

    International Nuclear Information System (INIS)

    Biagya, Robert Yakubu

    2002-12-01

    Small scale gold mining is responsible for about 5% of Ghana’s annual gold production. It is estimated that between 80,000 and 100,000 people are engaged in small scale gold mining either on part-time or permanent basis. Amalgamation is the preferred method used by small scale gold miners for extracting free gold from its ores. The rate at which mercury, an important input in this method, is discharged into the atmosphere and water bodies is alarming. This research describes the various mining and processing methods in small scale gold mining and the extent of mercury use and releases to the environment. It discusses mercury and its human and environmental effects. It defines the various forms of mercury, routes of exposure, toxic effects. The levels of exposure to mercury by all groups of small scale gold miners are determined, and the impacts on the miners and the environment are assessed. It concludes that: • Mercury is mainly released into the environment as a result of small scale gold mining through spillage of elemental mercury and evaporation of mercury from the amalgam and sponge gold when they are heated on open fire. • Mercury in environmental samples from small scale gold mining areas is well above standard limit values. • Mercury released into the environment through small scale gold mining impacts negatively on the miners themselves and the general environment. Finally, it recommends the need for the adoption of mercury emission reduction strategies for dealing with the mercury problem. (au)

  2. 40 CFR 792.63 - Maintenance and calibration of equipment.

    Science.gov (United States)

    2010-07-01

    ... SUBSTANCES CONTROL ACT (CONTINUED) GOOD LABORATORY PRACTICE STANDARDS Equipment § 792.63 Maintenance and..., maintenance, testing, calibration, and/or standardization of equipment, and shall specify, when appropriate... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Maintenance and calibration of...

  3. 40 CFR 160.63 - Maintenance and calibration of equipment.

    Science.gov (United States)

    2010-07-01

    ...) PESTICIDE PROGRAMS GOOD LABORATORY PRACTICE STANDARDS Equipment § 160.63 Maintenance and calibration of..., maintenance, testing, calibration, and/ or standardization of equipment, and shall specify, when appropriate... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Maintenance and calibration of...

  4. Immunological properties of gold nanoparticles.

    Science.gov (United States)

    Dykman, Lev A; Khlebtsov, Nikolai G

    2017-03-01

    In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis. In this review, we discuss recent progress in understanding the selective penetration of gold nanoparticles into immune cells. The interaction of gold nanoparticles with immune cell receptors is discussed. As distinct from other published reviews, we present a summary of the immunological properties of gold nanoparticles. This review also summarizes what is known about the application of gold nanoparticles as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo . For each of the above topics, the basic principles, recent advances, and current challenges are discussed. Thus, this review presents a detailed analysis of data on interaction of gold nanoparticles with immune cells. Emphasis is placed on the systematization of data over production of antibodies by using gold nanoparticles and adjuvant properties of gold nanoparticles. Specifically, we start our discussion with current data on interaction of various gold nanoparticles with immune cells. The next section describes existing technologies to improve production of antibodies in vivo by using gold nanoparticles conjugated with specific ligands. Finally, we describe what is known about adjuvant properties of bare gold or functionalized nanoparticles. In the Conclusion section, we present a short summary of reported data and some challenges and perspectives.

  5. Personal Protective Equipment

    National Research Council Canada - National Science Library

    1998-01-01

    ... of personal protective equipment A safety program for new employees is a necessary part of any orientation program An on-going safety program should be used to motivate employees to continue to use...

  6. Electronic equipment packaging technology

    CERN Document Server

    Ginsberg, Gerald L

    1992-01-01

    The last twenty years have seen major advances in the electronics industry. Perhaps the most significant aspect of these advances has been the significant role that electronic equipment plays in almost all product markets. Even though electronic equipment is used in a broad base of applications, many future applications have yet to be conceived. This versatility of electron­ ics has been brought about primarily by the significant advances that have been made in integrated circuit technology. The electronic product user is rarely aware of the integrated circuits within the equipment. However, the user is often very aware of the size, weight, mod­ ularity, maintainability, aesthetics, and human interface features of the product. In fact, these are aspects of the products that often are instrumental in deter­ mining its success or failure in the marketplace. Optimizing these and other product features is the primary role of Electronic Equipment Packaging Technology. As the electronics industry continues to pr...

  7. CV equipment responsibilities

    CERN Document Server

    Pirollet, B

    2008-01-01

    This document describes the limits of the responsibilities of the TS/CV for fire fighting equipment at the LHC. The various interfaces, providers and users of the water supply systems and clean water raising systems are described.

  8. Equipment for hydraulic testing

    International Nuclear Information System (INIS)

    Jacobsson, L.; Norlander, H.

    1981-07-01

    Hydraulic testing in boreholes is one major task of the hydrogeological program in the Stripa Project. A new testing equipment for this purpose was constructed. It consists of a downhole part and a surface part. The downhole part consists of two packers enclosing two test-sections when inflated; one between the packers and one between the bottom packer and the bottom of the borehole. A probe for downhole electronics is also included in the downhole equipment together with electrical cable and nylon tubing. In order to perform shut-in and pulse tests with high accuracy a surface controlled downhole valve was constructed. The surface equipment consists of the data acquisition system, transducer amplifier and surface gauges. In the report detailed descriptions of each component in the whole testing equipment are given. (Auth.)

  9. The extractive metallurgy of gold

    Energy Technology Data Exchange (ETDEWEB)

    Kongolo, K.; Mwema, M.D. [University of Lubumbashi, Zaire, Gecamines Metallurgical Research Centre, Likasi, Zaire, c/o Gecamines Brussels (Belgium)

    1998-12-15

    Moessbauer spectroscopy has been successfully used in investigation of the gold compounds present in ores and the gold species which occur during the process metallurgy of this metal. This paper is a survey of the basic recovery methods and techniques used in extractive metallurgy of gold. Process fundamentals on mineral processing, ore leaching, zinc dust cementation, adsorption on activated carbon, electrowinning and refining are examined. The recovery of gold as a by-product of the copper industry is also described. Alternative processing methods are indicated in order to shed light on new interesting research topics where Moessbauer spectroscopy could be applied.

  10. The extractive metallurgy of gold

    Science.gov (United States)

    Kongolo, K.; Mwema, M. D.

    1998-12-01

    Mössbauer spectroscopy has been successfully used in investigation of the gold compounds present in ores and the gold species which occur during the process metallurgy of this metal. This paper is a survey of the basic recovery methods and techniques used in extractive metallurgy of gold. Process fundamentals on mineral processing, ore leaching, zinc dust cementation, adsorption on activated carbon, electrowinning and refining are examined. The recovery of gold as a by-product of the copper industry is also described. Alternative processing methods are indicated in order to shed light on new interesting research topics where Mössbauer spectroscopy could be applied.

  11. The extractive metallurgy of gold

    International Nuclear Information System (INIS)

    Kongolo, K.; Mwema, M.D.

    1998-01-01

    Moessbauer spectroscopy has been successfully used in investigation of the gold compounds present in ores and the gold species which occur during the process metallurgy of this metal. This paper is a survey of the basic recovery methods and techniques used in extractive metallurgy of gold. Process fundamentals on mineral processing, ore leaching, zinc dust cementation, adsorption on activated carbon, electrowinning and refining are examined. The recovery of gold as a by-product of the copper industry is also described. Alternative processing methods are indicated in order to shed light on new interesting research topics where Moessbauer spectroscopy could be applied

  12. Surface-stabilized gold nanocatalysts

    Science.gov (United States)

    Dai, Sheng [Knoxville, TN; Yan, Wenfu [Oak Ridge, TN

    2009-12-08

    A surface-stabilized gold nanocatalyst includes a solid support having stabilizing surfaces for supporting gold nanoparticles, and a plurality of gold nanoparticles having an average particle size of less than 8 nm disposed on the stabilizing surfaces. The surface-stabilized gold nanocatalyst provides enhanced stability, such as at high temperature under oxygen containing environments. In one embodiment, the solid support is a multi-layer support comprising at least a first layer having a second layer providing the stabilizing surfaces disposed thereon, the first and second layer being chemically distinct.

  13. 31 CFR 100.4 - Gold coin and gold certificates in general.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Gold coin and gold certificates in... EXCHANGE OF PAPER CURRENCY AND COIN In General § 100.4 Gold coin and gold certificates in general. Gold coins, and gold certificates of the type issued before January 30, 1934, are exchangeable, as provided...

  14. Determining gold content

    International Nuclear Information System (INIS)

    Clayton, C.G.; Wormald, M.R.

    1981-01-01

    A method for determining the gold content of a material, comprises irradiating a body of the material with neutrons and determining the intensity of γ-rays having an energy of 279 keV arising from the reaction 179 Au(nn') 179 Au → 279 keV. The apparatus has means for conveying the materials past an assembly, which has a neutron source, which does not produce neutrons having sufficient energy to excite fast neutron reactions in non-auriferous constituents. (author)

  15. Turning lead into gold

    DEFF Research Database (Denmark)

    Jensen, Steffen Moltrup Ernø

    For years the field of entrepreneurship has been blinded by the alchemical promise of turning lead into gold, of finding the ones most likely to become the next Branson, Zuckerberg or Gates. The promise has been created in the midst of political and scientific agendas where certain individuals...... is not to accumulate state or market wealth, but for entrepreneurial skills to become tools towards the liberation of the individual from oppressive systems of control – essentially to add public value rather than economic value. In this presentation I will sketch an anarchist perspective on entrepreneurship, looking...

  16. Determination of Gold from Gold Matrix of North Western Nigeria ...

    African Journals Online (AJOL)

    The research paper presents analytical results of Au, Mn and V concentrations of some Nigerian gold ores using two techniques: epithermal neutron activation analysis (ENAA) and proton induced X-ray emission (PIXE). Fourteen samples were collected from gold fields of North Western Nigeria, prepared separately to a ...

  17. The determination, by x-ray-fluorescence spectrometry, of gold in activated charcoal

    International Nuclear Information System (INIS)

    Austen, C.E.

    1977-01-01

    A rapid method is described for the determination of gold in activated charcoal by X-ray-fluorescence spectrometry. Compensation for matrix effects is achieved by means of platinum that is added for use as an internal standard. Calibration is achieved by use of a series of synthetic standards that are made by the spiking of barren charcoal with gold and platinum. The limit of determination is about 8 p.p.m. of gold, and the relative standard deviation is 1,2 per cent at a concentration level of 2300 p.p.m

  18. Equipment abnormality monitoring device

    International Nuclear Information System (INIS)

    Ando, Yasumasa

    1991-01-01

    When an operator hears sounds in a plantsite, the operator compares normal sounds of equipment which he previously heard and remembered with sounds he actually hears, to judge if they are normal or abnormal. According to the method, there is a worry that abnormal conditions can not be appropriately judged in a case where the number of objective equipments is increased and in a case that the sounds are changed gradually slightly. Then, the device of the present invention comprises a plurality of monitors for monitoring the operation sound of equipments, a recording/reproducing device for recording and reproducing the signals, a selection device for selecting the reproducing signals among the recorded signals, an acoustic device for converting the signals to sounds, a switching device for switching the signals to be transmitted to the acoustic device between to signals of the monitor and the recording/reproducing signals. The abnormality of the equipments can be determined easily by comparing the sounds representing the operation conditions of equipments for controlling the plant operation and the sounds recorded in their normal conditions. (N.H.)

  19. Prioritizing equipment for replacement.

    Science.gov (United States)

    Capuano, Mike

    2010-01-01

    It is suggested that clinical engineers take the lead in formulating evaluation processes to recommend equipment replacement. Their skill, knowledge, and experience, combined with access to equipment databases, make them a logical choice. Based on ideas from Fennigkoh's scheme, elements such as age, vendor support, accumulated maintenance cost, and function/risk were used.6 Other more subjective criteria such as cost benefits and efficacy of newer technology were not used. The element of downtime was also omitted due to the data element not being available. The resulting Periop Master Equipment List and its rationale was presented to the Perioperative Services Program Council. They deemed the criteria to be robust and provided overwhelming acceptance of the list. It was quickly put to use to estimate required capital funding, justify items already thought to need replacement, and identify high-priority ranked items for replacement. Incorporating prioritization criteria into an existing equipment database would be ideal. Some commercially available systems do have the basic elements of this. Maintaining replacement data can be labor-intensive regardless of the method used. There is usually little time to perform the tasks necessary for prioritizing equipment. However, where appropriate, a clinical engineering department might be able to conduct such an exercise as shown in the following case study.

  20. Activation analysis in gold industry

    International Nuclear Information System (INIS)

    Kist, A. A.

    2003-01-01

    Nuclear techniques and methods were, are, and will be very important for many fields of science, agriculture, industry, etc. Among other examples one can remember role of the nuclear medicine (radiotherapy and radiodiagnostic methods) or semiconductors (communication, computing, information, etc.) which industrial production has been on initial stage based on activation analysis. One of very illustrative examples is application of nuclear methods in gold industry. This is given by favorable nuclear properties of gold. Uzbekistan is one of the main producers of gold. Open-cast mining and hydro metallurgic extraction (using leaching by cyanide and sorption by ion-exchange resin) is the mostly used technology. The typical gold ores are sulfide and contain elevated concentration of As and Sb. That needs special technology of gold extraction. Importance of gold for Uzbekistan economy is a reason why for many years there are carried out studies concerning to gold production. These studies include also nuclear methods and their results are successfully used in gold industry. The present paper gives a brief overview for period of 25 years. For many reasons most of these studies were not published before completely. Despite some results are obtained decades ago we decided to present the overview as an example how nuclear methods can cover requirements of the whole process. We are trying to sort these studies according to methods and applications

  1. VIRTUAL ELECTRONIC COMPONENTS OF THE ELECTRONIC EQUIPMENT

    Directory of Open Access Journals (Sweden)

    E. Lazarevich

    2013-01-01

    Full Text Available The article is present new idea of the creation, developments and improvements of the electronic equipment of complex systems by means of the virtual electronic components. The idea of the virtual electronic components is a presentation and perception of the creation and developments of the equipment on two forming: real – in the manner of standard marketed block of the intellectual property and image – in the manner of virtual component. The real component in most cases slows the development of the electronic equipment. The imaginary component is the «locomotive» of development of the electronic equipment. The Imaginary component contains the scientific has brushed against developer. The scientific has brushed against developer reveals of itself in the manner of virtual component on the modern level of the design rates of microelectronics.

  2. Using operational equipment to read accident dosemeters.

    Science.gov (United States)

    Devine, R T; Vigil, M M; Martinez, W A

    2004-01-01

    Analysis of accident dosemeters usually involves the use of laboratory-based counting equipment. Gamma spectrometers are used for indium, copper and gold, and alpha-beta detectors for sulphur. This equipment is usually not easily transported due to the shielding required and the weight and delicacy of the counters. For intercomparison studies that require reading the dosemeters on site, a transportable system is required unless the site operating the study can count samples for all the participants. In the case of an actual accident these systems would have a difficulty in counting a large number of accident dosemeters. In an accident, personnel are usually subdivided according to their level of exposure. Those exposed to higher doses are treated immediately. An alternate system should be made available to handle the dosemeters worn by those personnel are likely to receive lower doses. Improvements in portable operational equipment for gamma and beta monitoring allow their use as spectrometers. Such a system was used for the SILENE intercomparison conducted at IRSN Valduc on 12 June and 19, 2002, and the preliminary results compared well with the other participants.

  3. Neutron activation analysis of geological samples for gold and accessory elements power reactor

    International Nuclear Information System (INIS)

    Burmistrenko, Yu.N.; Medvedev, A.A.; Kovalenko, V.V.; Markov, A.V.

    1986-01-01

    Possibility of using a power reactor for neutron activation analysis to detect gold and accompanying elements in geological samples of a region was investigated. Specimens (gold-containing samples and standards) were irradiated in a spare channel for ionization chambers located outside the core in graphite reflector. Spectrometry was conducted with the help of a semiconducting detector with LP 4900 multichannel analizer. Sensitivity threshold for gold was (1-3)10 -6 % - (1-2)10 -5 %. It is shown that this method can be used not only for gold detection but for high-sensitive multielement analysis of geological samples

  4. Equipment Operational Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Greenwalt, B; Henderer, B; Hibbard, W; Mercer, M

    2009-06-11

    The Iraq Department of Border Enforcement is rich in personnel, but poor in equipment. An effective border control system must include detection, discrimination, decision, tracking and interdiction, capture, identification, and disposition. An equipment solution that addresses only a part of this will not succeed, likewise equipment by itself is not the answer without considering the personnel and how they would employ the equipment. The solution should take advantage of the existing in-place system and address all of the critical functions. The solutions are envisioned as being implemented in a phased manner, where Solution 1 is followed by Solution 2 and eventually by Solution 3. This allows adequate time for training and gaining operational experience for successively more complex equipment. Detailed descriptions of the components follow the solution descriptions. Solution 1 - This solution is based on changes to CONOPs, and does not have a technology component. It consists of observers at the forts and annexes, forward patrols along the swamp edge, in depth patrols approximately 10 kilometers inland from the swamp, and checkpoints on major roads. Solution 2 - This solution adds a ground sensor array to the Solution 1 system. Solution 3 - This solution is based around installing a radar/video camera system on each fort. It employs the CONOPS from Solution 1, but uses minimal ground sensors deployed only in areas with poor radar/video camera coverage (such as canals and streams shielded by vegetation), or by roads covered by radar but outside the range of the radar associated cameras. This document provides broad operational requirements for major equipment components along with sufficient operational details to allow the technical community to identify potential hardware candidates. Continuing analysis will develop quantities required and more detailed tactics, techniques, and procedures.

  5. Prehospital Emergencies in Illegal Gold Mining Sites in French Guiana.

    Science.gov (United States)

    Egmann, Gérald; Tattevin, Pierre; Palancade, Renaud; Nacher, Matthieu

    2018-03-01

    Illegal gold mining is flourishing in French Guiana, existing outside the law due to both the high cost of gold mining permits and the challenges of law enforcement within the Amazon forest. We report the characteristics of, and the medical responses to, medical emergencies in illegal gold mining sites. We performed a retrospective study of all medical emergencies reported from illegal gold mining sites to the centralized call office of SAMU 973 from 1998 through 2000 and from 2008 through 2010. According to the national health care system, any medical emergency within the territory is handled by the prehospital emergency medical service (SAMU 973), irrespective of the patients' legal status. Data were extracted from the SAMU 973 notebook registry (1998-2000) or the SAMU 973 computerized database (2008-2010) and werre collected using a standardized questionnaire. Of 71,932 calls for medical emergencies in French Guiana during the study periods, 340 (0.5%) originated from illegal gold mining sites. Of these, 196 (58%) led to medical evacuation by helicopter, whereas the overall rate of evacuation by helicopter after placing a call to SAMU 973 was only 4% (3020/71,932; PAmazon forest mostly include infectious diseases, followed by trauma, and often require medical evacuation by helicopter. Our study suggests that implementation of preventive medicine within gold mining sites, irrespective of their legal status, could be cost-effective and reduce morbidity. Copyright © 2017 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  6. Charging equipment. Ladegeraet

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, E

    1981-09-17

    The invention refers to a charging equipment, particularly on board charging equipment for charging traction batteries of an electric vehicle from the AC mains supply, consisting of a DC converter, which contains a controlled power transistor, a switching off unloading circuit and a power transmitter, where the secondary winding is connected in series with a rectifier diode, and a smoothing capacitor is connected in parallel with this series circuit. A converter module is provided, which consists of two DC voltage converters, whose power transistors are controlled by a control circuit in opposition with a phase displacement of 180/sup 0/.

  7. EPERC: The European Pressure Equipment Research Council

    International Nuclear Information System (INIS)

    Darlaston, J.; McAllister, S.

    1998-01-01

    The European Pressure Equipment Research Council (EPERC) is a European Network of industries, research laboratories, inspection bodies and governmental institutions set up to foster co-operative research for the greater benefit of the European industry. The concept of a European Research Council originated at the PVRC meeting in Cannes in 1989 and since this time volunteers from the industry, research laboratories and of the European Commission Joint Research Centre, Petten have worked together to create a Statute for EPERC. In the context of the pressure equipment industry, the creation of EPERC is extremely pertinent, since in the near future, a Council directive on pressure equipment will replace the existing national regulations. In parallel to this, work is in progress for the elaboration of European Standards. It is useful to recall that ''Harmonised Standards'' will be the privileged means of complying with the Essential Safety Requirements of the directive. (author)

  8. Neutron activation for logging the distribution of gold in bore-hole cores

    International Nuclear Information System (INIS)

    Rahmanian, H.; Watterson, J.I.W.

    1992-01-01

    A new method for the non-destructive determination of gold in bore-hole cores has been developed using instrumental neutron activation analysis with a 252 Cf source. The procedure obtains the distribution and concentration of gold along the longitudinal axis of the core i.e. a log of the gold concentration. The accuracy of the method is comparable to fire assay at a level of 2 ppm and has a detection limit of 1 ppm under the conditions used. The assay of the gold is carried out by employing a novel variation of the conventional comparator method using gold wires as both standard and flux monitor. A method is described for logging gold in bore-hole cores using neutron activation with a 160 μg 252 Cf neutron source. The method has a limit of detection of about 1 ppm under the described conditions. (author)

  9. OEE and equipment effectiveness : an evaluation

    NARCIS (Netherlands)

    Ron, de A.J.; Rooda, J.E.

    2006-01-01

    The overall equipment effectiveness or efficiency (OEE) is a metric that has been accepted in the semiconductor industry. OEE is simple and clear, and standards and guidelines have been developed. Nonetheless, the literature indicates imperfections in applying OEE with regard to the time base and

  10. EQuIP-ped for Success

    Science.gov (United States)

    Ewing, Molly

    2015-01-01

    The Educators Evaluating the Quality of Instructional Products (EQuIP) Rubric for science is a new tool for science educators that provides criteria by which to examine the alignment and overall quality of lessons and units with respect to the "Next Generation Science Standards" ("NGSS"). The rubric criteria are divided into…

  11. The LHC's equipment all in step

    CERN Multimedia

    2005-01-01

    Over 80% of the control equipment for the LHC will be connected by a special communication network known as WorldFIP, which has been chosen for its very precise timing, excellent operating performance and robustness in difficult environments. Over 350 kilometres of this network are currently being installed in the LHC tunnel and checked for compliance with the required standards.

  12. 22 CFR 226.34 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Property Standards § 226.34 Equipment. (a) Unless the agreement provides... to provide services to non-Federal outside organizations for a fee that is less than private...

  13. 7 CFR 3019.34 - Equipment.

    Science.gov (United States)

    2010-01-01

    ... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 3019... accounting records shall be investigated to determine the causes of the difference. The recipient shall, in... requirement for the equipment exists in other Federal agencies. The Federal awarding agency shall issue...

  14. Radiation protection calculations for diagnostic medical equipment

    International Nuclear Information System (INIS)

    Klueter, R.

    1992-01-01

    The standards DIN 6812 and DIN 6844 define the radiation protection requirements to be met by biomedical radiography equipment or systems for nuclear medicine. The paper explains the use of a specific computer program for radiation protection calculations. The program offers menu-controlled calculation, with free choice of the relevant nuclides. (DG) [de

  15. 36 CFR 1210.34 - Equipment.

    Science.gov (United States)

    2010-07-01

    ... 1210.34 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION GENERAL RULES... data, including date of disposal and sales price or the method used to determine current fair market... the following standards. For equipment with a current per unit fair market value of $5,000 or more...

  16. Experimental equipment, ch. 6

    International Nuclear Information System (INIS)

    Boomstra, F.; Hoogenboom, A.M.; Prins, C.M.; Strasters, B.A.; Vermeer, A.; Wit, P. de; Zwol, N.A. van.

    1977-01-01

    The experimental equipment in use at Utrecht university is discussed. Attention is paid to the tandem Van de Graaff accelerator and the 4MV and 1MV accelerators. The detection systems for gamma-ray spectroscopy are reviewed with emphasis on the compton-suppression spectrometer. The data-handling system used for experiments with the tandem is also briefly discussed

  17. Equipment gift to Monaco

    International Nuclear Information System (INIS)

    1970-01-01

    Research work at the Agency's Laboratory of Marine Radioactivity in Monaco, including that concerned with pollution of the sea, has been made more effective by its latest acquisition of equipment. This is a spectrophotometer donated by the Federal Republic of Germany. (author)

  18. Safeguards techniques and equipment

    International Nuclear Information System (INIS)

    1997-01-01

    The current booklet is intended to give a full and balanced description of the techniques and equipment used for both nuclear material accountancy and containment and surveillance measures, and for the new safeguards measure of environmental sampling. As new verification measures continue to be developed, the material in the booklet will be periodically reviewed and updated versions issued. (author)

  19. Equipping tomorrow's fire manager

    Science.gov (United States)

    Christopher A. Dicus

    2008-01-01

    Fire managers are challenged with an ever-increasing array of both responsibilities and critics. As in the past, fire managers must master the elements of fire behavior and ecology using the latest technologies. In addition, today’s managers must be equipped with the skills necessary to understand and liaise with a burgeoning group of vocal stakeholders while also...

  20. Electrical equipment design library

    International Nuclear Information System (INIS)

    1994-01-01

    This book guides the design supervision, construction order for electrical equipment. The contents of this library are let's use electricity like this, leading-in-pole and casual power, electric pole install below 300KVA, electric pole install below 301∼1000KVA, electric pole install exceed 1000KVA, rooftop install exceed 1000KVA, CUBICLE type, 154KV services. It adds an appendix.