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Sample records for giovanna scarel claudia

  1. Interview with Claudia Roden

    OpenAIRE

    Mac Con Iomaire, Máirtín

    2016-01-01

    Claudia Roden is an award winning cookbook writer and cultural anthropologist based in the United Kingdom. She is co-chair with Paul Levy of the Oxford Symposium on Food and Cookery. She was born in 1936 in Cairo, Egypt. After completing her formal education in Paris, she moved to London to study at Saint Martin's School of Art. She began her career as a painter, but soon realised following the Suez Crisis that the Jewish food culture of Egypt was disappearing which led her to begin her study...

  2. Claudia Quinta (Pro Caelio 34 and an altar to Magna Mater

    Directory of Open Access Journals (Sweden)

    Eleanor Winsor Leach

    2010-11-01

    Full Text Available Among the items of sculpture from the Capitoline collection now housed in the Museum of the Power Station Montemartini is a marble relief altar of the Claudian Period (E. Simon's dating dedicated to the mater deorum and the navis salvia and depicting the arrival of the goddess Cybele at Rome by ship. The dedicator is one Claudia Syntyche and the sculpture alludes to the legends attached to a much honored woman of the Claudian family whom Cicero, in his oration pro Caelio brought on stage in a cameo appearance to bolster his case against the controversial contemporary woman Clodia Metelli as one of the accusers of his client M. Caelius Rufus. This paper will consider questions raised by the iconography of the altar with reference to the development of Claudia's legend in Roman mythology and subsequently ask who was this Claudia the dedicator and why did she choose Magna Mater for her vow?

  3. De la “mujer moderna” a la “mujer liberada”. Un análisis de la revista Claudia de México (1965-1977)

    OpenAIRE

    Felitti, Karina

    2018-01-01

    Resumen: Este artículo analiza la revista femenina Claudia de México, desde su aparición en 1965 hasta 1977, cuando se pone en marcha el Programa Nacional de Planificación Familiar (1977). Claudia se presenta como la revista para la “mujer moderna”, interpelándola a partir de la moda, las recetas de cocina, las publicidades, y con informes que abordan cuestiones sexuales y reproductivas, como el placer sexual, la anticoncepción y el aborto. A comienzos de los años setenta, las consignas de “l...

  4. O JARDIM DE SI: o imaginário de CLAUDIA ROQUETTE-PINTO

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    Antonio Rediver Guizzo

    2014-12-01

    Full Text Available A lírica de Claudia Roquette-Pinto encontra no ambiente do jardim, simulacro miniaturizado do mundo natural, as imagens que compõem a representação simbólica do conflito surgido entre o eu e o mundo, e intensa reflexão metapoética. As imagens recorrentes da queda, da flor, da escuridão e do corpo que enformam a materialidade simbólica de Roquette-Pinto revelam uma lírica constituída em uma zona de transição, estabelecida entre saturação da ordem social orientada pelo aproveitamento racional do mundo e pela dominação da natureza, e a insurgência pós-moderna de uma ordem ecológica, na qual se privilegia a fruição mais livre do presente. A abordagem metodológica escolhida para adentrar a lírica de Claudia Roquette-Pinto orienta-se a partir da teoria das estruturas antropológicas do imaginário proposta por Gilbert Durand conjuntamente com as reflexões sobre a sociedade contemporânea presentes na obra do sociólogo Michel Maffesoli. Na primeira e segunda seção do artigo, apresentam-se brevemente considerações sobre o imaginário e o estruturalismo figurativo de Gilbert Durand; na terceira seção analisa-se um pequeno recorte da lírica de Roquette-Pinto.

  5. BAELO CLAUDIA Y POLLENTIA: NUEVAS EVIDENCIAS SOBRE LAS FLUCTUACIONES ECONÓMICAS EN LA HISPANIA ROMANA DE LOS SIGLOS I-II D. C. (Baelo Claudia and Pollentia: new evidence on the economic fluctuations in Roman Spain during the first and second centuries AD

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    Pascual Izquierdo-Egea

    2012-06-01

    Full Text Available La revisión cronológica de la necrópolis sureste de Baelo Claudia (Bolonia-Tarifa, Cádiz y la de Can Fanals, en Pollentia (Alcudia, Mallorca, ha permitido ampliar el conocimiento sobre las fluctuaciones económicas en la Hispania romana de los siglos I y II de nuestra era y los cambios sociales asociados a las mismas. Se ha obtenido una nueva confirmación del impacto de la gran crisis de tiempos de Tiberio en los registros funerarios de Baelo Claudia y Pollentia, detectada previamente en Ampurias o Emporiae (Gerona. La bonanza de la época de Claudio se puede comprobar en Baelo Claudia de forma más elocuente que en Emporiae. Ahora bien, esta coincidencia en el devenir económico se rompe a lo largo de la segunda mitad del siglo I d. C., en concreto durante el periodo comprendido entre Nerón y principios de los Flavios. Es entonces cuando, frente a la decadente Ampurias, una pujante Pollentia sigue los pasos de la opulenta Baelo mostrando su mayor prosperidad. Sin embargo, esas tres ciudades romanas de Hispania mantienen un claro nexo basado en la exhibición durante ese periodo de su máxima complejidad social. Siempre se da una proporción directa entre la acumulación económica amortizada en los ajuares y la diferenciación entre los individuos, salvo en dos casos excepcionales. Uno, ya conocido, se refiere a la Ampurias de la segunda mitad del siglo I d. C., donde el empobrecimiento que la caracteriza se asocia con un incremento de la distancia social. Y, el otro, corresponde al extraño fenómeno documentado en la Pollentia del siglo II d. C. En esta sigue creciendo el gasto funerario, pero la diferenciación social medida desciende durante la primera mitad hasta caer abruptamente a lo largo de la segunda parte de dicha centuria. No obstante, lo más importante es que, por ahora, se detecta la misma evolución de la diferenciación social en Emporiae, Baelo Claudia y Pollentia desde la época de Tiberio hasta la primera mitad del

  6. How Brazil joined the quest for a yellow fever vaccine. Interview by Claudia Jurberg and Julia D'Aloisio..

    Science.gov (United States)

    Benchimol, Jaime

    2013-03-01

    Brazil recently announced an agreement between its Bio-Manguinhos vaccine unit and two US companies to research and develop a new yellow fever vaccine. Claudia Jurberg and Julia D'Aloisio talk to Jaime Benchimol about the controversial history of the development of the vaccine that benefits millions of people today.

  7. The Art of ATLAS; multimedia installation by Neal Hartman and Claudia Marcelloni at Thinktank science museum in Birmingham, UK.

    CERN Multimedia

    Claudia Marcelloni

    2010-01-01

    The Art of ATLAS is an multimedia installation, developed by Neal Hartman and Claudia Marcelloni about the physicists, engineers and technicians behind the ATLAS Experiment. The installation will been shown at Planetarium entrance of the Thinktank science museum in Birmingham, UK from October 2010 until January 2011.

  8. House, a feminine noun: representating architectural spaces in Casa e Jardim and Casa Claudia in age the great magazines

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    Rafael Alves Pinto Junior

    2011-12-01

    Full Text Available The emergence of magazines focusing on architecture and aimed at the general public, such as Casa e jardim in the 1950s and Casa Claudia in the 1970s, represented the creation of a culture of living associated with domestic spaces and the values this space represents as a typological object after the second half of the 20th century. Among other things, it affirmed the values of the social roles of women and architecture as the depository of the attributes of privacy and intimacy: the locus of family, memory and affection. The magazines set the tone for representing the architectural space as an area for living, legitimizing behaviors while exercising an aesthetic pedagogy, ushering in a culture associated with living and establishing a source for imagined ways of building in Brazil. By affirming an image of civilization, both Casa e jardim and Casa Claudia became a benchmark for other periodicals devoted to this theme.

  9. Rupture on the Brazilian documentary photography: Claudia Andujar and the poetry of the (invisible

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    Rafael Castanheira Pedroso de Moraes

    2014-07-01

    Full Text Available This article aims to analyse Claudia Andujar’s photographies from her books Yanomami and The vulnerability of being not only to reflect about their conceptual characteristics that mix social engagement and personal expression, but also to identify the photographer’s technical and aesthetic choices to document the invisible phenomenons of the Yanomami’s culture. Using innovatives strategies of representation, Andujar reached inedited results from the political and aesthetic points of view, which marked a break with the Brazilian documentary photography history.

  10. From “Modern Woman” to “Liberated Woman.” An Analysis of the Magazine Claudia de México (1965-1977

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    Karina Felitti

    2017-12-01

    Full Text Available This article analyzes the women’s magazine Claudia de México from its first appearance in 1965 up until 1977, when the National Family Planning Program was launched. Claudia presented itself as a magazine for the “modern woman,” with fashion tips, recipes and articles that addressed sexual and reproductive issues such as sexual pleasure, birth control and abortion. Starting in the 1970s, slogans of “women’s liberation” made their appearance and, though they were criticized, they nevertheless marked the beginning of a new era in which demographic policy began to uphold the rights of women to make decisions on reproductive issues and in which “machismo” became something to be eliminated. This article examines this transition, combining an in-depth analysis of the magazine’s contents (articles, photographs, advertising with other sources, such as contemporary films, Second Wave feminist writings, interviews with women who came of age in those years and secondary literature examining the period.

  11. Stuccos and roman concretes of the Baelo Claudia city (Cádiz: Characterization and causes of decay

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    Puertas, Francisca

    1994-12-01

    Full Text Available This paper presents the study of the nature and conservation state of different stuccos and Roman concretes from the Roman city of Baelo Claudia (Cádiz. The chemical, mineralogical and microstructural compositions of the said materials have been established. Different causes of their decay have been found, among which we should emphasize the loss of the binding material (lime, basically due to the processes of partial solubilization; the lack of bond between the stuccos and the support stone, due to the different characteristics and properties of these two materials; and finally, the biological-type attack with the proliferation and colonization of different organisms in the said materials.

    Se ha estudiado la naturaleza y estado de conservación de distintos estucos y hormigones romanos procedentes de la ciudad romana de Baelo Claudia (Cádiz. Se ha establecido la composición química, mineralógica y microestructural de dichos materiales. Se han encontrado diferentes causas de su deterioro. Entre ellas, cabe destacar la pérdida del material ligante (cal, fundamentalmente motivado por procesos de solubilización parcial; la falta de adherencia entre los estucos y la piedra soporte, debido a las diferentes características y propiedades de ambos materiales; y finalmente, también al ataque de tipo biológico, con la proliferización y colonización de distintos organismos en dichos materiales.

  12. Elements of Yanomami identity in the photographs of Cláudia Andujar Elementos de identidade cultural Yanomami nas fotografias de Claudia Andujar

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    Miguel Luiz Contani

    2006-12-01

    Full Text Available Considering that it is through the concept of index, that plastic and meaningful characteristics of certain issues are revealed, it is assumed that approaching photography to cultural identity matters might be a wise procedure. This paper is aimed at analyzing pictures shot by photographer Claudia Andujar among the Yanomami, in the 1970’s to find out, through semiotic aesthetic approaches, how such images convey some elements of those Indians’ cultural identity. Tendo em conta o conceito de índice, em que características plásticas e significativas de um determinado recorte se revelam, parte-se do pressuposto de que aproximar fotografia e questões de identidade cultural pode tornar-se um rico procedimento. Este artigo se propõe analisar fotografias realizadas junto aos Yanomami, na década de 1970 pela fotógrafa Claudia Andujar, a fim de compreender, por meio da abordagem estética da semiótica, a presença, nessas imagens, de elementos de identidade cultural daqueles índios.

  13. Ancient earthquakes in the Roman city of Baelo Claudia (Cadiz, South of Spain): Fifteen years of archaeosimology research

    Energy Technology Data Exchange (ETDEWEB)

    Silva, P.G.; Giner-Robles, J.L.; Reicherter, K.; Rodriguez-Pascua, J.L.; Gruetzner, C.; Garcia-Jimenez, I.; Carrasco Garcia, P.; Bardaji, T.; Santos, G.; Roquero, E.; Roez, J.; Perucha, M.A.; Perez-Lopez, R.; Fernandez Macarro, B.; Martinez-Grana, A.; Goy, J.L.; Zazo, C.

    2016-07-01

    This work illustrates the state of the art on archaeoseismology of the ancient Roman city of Baelo Claudia (Tarifa, Cádiz) after nearly fifteen years of research. This ancient Roman site was affected by two earthquakes in the years AD 40–60 and AD 260–290 which promoted important urban and architectural changes and eventually the destruction and further abandonment of the city in AD 365–390. Earthquake Archaeoseismological Effects (EAEs) are catalogued, described and mapped in the entire monumental sector of the city mainly witnessing the last earthquake which occurred in AD 260–290. Mapping of oriented EAEs illustrate damage distribution all over the lower sector of the city, as well as the occurrence of suspect coseismic landslide and tsunami events. The structural analysis of oriented EAEs throughout the entire mapped sector suggests that the intervening ground motion was preferentially oriented in a SW to NE direction. The geoarchaeological analysis and some relevant archaeological anomalies, strongly suggest the occurrence of coeval tsunami events during both ancient earthquakes, pointing to the occurrence of an offshore seismic source SSW of the city. Several N-S normal faults have been identified around the Bolonia Bay area and some of them continue offshore SSW of Baelo Claudia. These faults with clear Quaternary activity can be considered as the more probable seismic sources for the events affecting the ancient Roman site and they are consistent with the mapped damage orientation displayed by the structural analysis of EAEs within the old Roman city. (Author)

  14. European co-production funds and Latin American cinema:processes of othering and bourgeois cinephilia in Claudia Llosa's La teta asustada

    OpenAIRE

    Shaw, Deborah

    2016-01-01

    Latin American women’s filmmaking has an unprecedented international profile thanks to the filmsof the Peruvian director Claudia Llosa, and the Argentine directors Lucía Puenzo and Lucrecia Martel. What is frequently unacknowledged when discussing the work of these award-winning filmmakers is the fact that all of their films are co-productions with Europe, and that programmes such as Cinéfondation, a programme aligned with the Cannes film festival, the Hubert Bals Fund,the World Cinema Fund a...

  15. Claudia: la revista de la mujer moderna en la Argentina de los años sesenta (1957-1973)

    OpenAIRE

    Cosse, Isabella

    2011-01-01

    Claudia es recordada como la revista femenina de la mujer moderna de los años 60. Este recuerdo pone de relieve el impacto que significó, en 1957, la aparición de este emprendimiento de la editorial Abril en la renovación del periodismo y de la imagen femenina. Pero desconoce las contradicciones de la línea editorial respecto al modelo femenino y los cambios que sufrió a lo largo del tiempo. Con estas ideas, el artículo se propone analizar la doble renovación que supuso la revista en el perio...

  16. Culto a los ancestros en época romana: los cipos funerarios de las necrópolis de Baelo Claudia (Bolonia, Cádiz

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    Jiménez Díez, Alicia

    2007-12-01

    Full Text Available A quite large number of proposals have been published about the meaning of a singular group of pieces (termed ‘dolls’ at the beginning of the twentieth century found in association with different tombs in the necropoleis of Baelo Claudia. In this paper I suggest we can only understand the funerary cippi of Bolonia within a wider ritual context that places these sculptures in relation with cult to ancestors (that are seen and represented as a community where individuals can not be differentiated not only in the tomb, but also in domestic and sanctuary contexts.Se han publicado propuestas muy diversas para explicar la función de un singular conjunto de piezas (bautizadas como “muñecos” a principios del siglo XX que se hallaron asociadas a distintos enterramientos de las necrópolis de Baelo Claudia. En el presente estudio se propone entender los cipos funerarios de Bolonia dentro de un contexto ritual más amplio que permite relacionarlos con el culto a los ancestros (concebidos y representados como una comunidad de carácter indiferenciado, no sólo en la tumba, sino también en ambientes domésticos y en santuarios.

  17. Imágenes de sobrevivencia: del realismo urbano del Grupo Chaski al Perú contemporáneo de Claudia Llosa

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    Jorge Zavaleta Balarezo

    2018-01-01

    Full Text Available El artículo analiza los trabajos iniciales del Grupo Chaski y de Claudia Llosa, dos puntos de referencia en el cine peruano contemporáneo. A través de la crítica al argumento y las características de las películas de estos cineastas, se construye una imagen del Perú, un país que volvió a la democracia en 1980 y, desde entonces, ha sido gobernado por presidentes posteriormente acusados de corrupción y abuso de poder como Alan García, Alberto Fujimori, Alejandro Toledo y Ollanta Humala. Las películas de Chaski inciden en la pobreza y vulnerabilidad de niños enfrentados a la gran ciudad, Lima, y se anticipan a ese cine de la marginalidad que en los años 90 produjo cintas tan logradas como Pizza, birra, faso, La vendedora de rosas, Ciudad de Dios o Ratas, ratones, rateros. La obra de Claudia Llosa, por su parte, llamó la atención internacional por el triunfo de su segunda película, La teta asustada, en el Festival de Berlín. Esta película, que marca una continuidad respecto de la primera, Madeinusa, es un retrato de los años posteriores a la guerra interna, los de la barbarie de Sendero Luminoso y la respuesta de las Fuerzas Armadas. El artículo aspira a ofrecer una mirada global de la sociedad peruana de los últimos treinta años, marcados por la pobreza estructural, el terrorismo, la aplicación de reformas neoliberales y la corrupción a todo nivel del estado.

  18. O trabalho de Claudia Andujar a partir de uma história da fotografia engendrada por meandros discursivos institucionais

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    Carolina Soares

    Full Text Available resumo Este texto resgata a produção fotográfica de Claudia Andujar do final dos anos de 1950 e início de 1960 - ainda anterior ao trabalho que viria a desenvolver com os Yanomami - para uma análise que leve em consideração a dimensão do assunto escolhido; o resultado visual de sua representação e a forma de circulação do trabalho. Ao enfatizar esses aspectos, o objetivo é entender de que modo a estética desenvolvida pela artista em questão é contaminada e assim constituída por critérios discursivos alinhados a uma história da fotografia forjada por mecanismos institucionais.

  19. Espejel Carvajal Claudia, La justicia y el fuego. Dos claves para leer la Relación de Michoacán

    OpenAIRE

    Michelet, Dominique

    2014-01-01

    Il est des ouvrages sur lesquels il n’est jamais trop tard pour attirer l’attention des lecteurs, au-delà des cercles des spécialistes qui, eux, en connaissent ou, au moins, en supputent les mérites dès avant leur parution. Tel est le cas de cette somme que Claudia Espejel a su tirer de sa thèse de doctorat, soutenue en 2004 au Centre d’études historiques du Colegio de Michoacán. La Relación de Michoacán – ou, plus exactement, la Relación de las cerimonias y rictos y población y gobernación d...

  20. Towards a reconstruction of the contributions of the Argentine experience to the development of International Human Rights Law: the voices of Claudia Fontes and Paula Bombara

    OpenAIRE

    Estefanía Giaccone; Viviana Kühne; Agustina Vázquez

    2017-01-01

    In the present dissertation, we intend to relate and contrast the representations that emerge from legal and political-institutional discourses on the crime of forced disappearance of persons in the Argentinian historical experience. In this sense, we will analyze the representations of the crime of forced disappearance of persons in two artistic works: The Reconstruction of Pablo Miguez Portrait, Claudia Fontes’ sculpture, and The Sea and the Serpent, a novel by Paula Bombara, in order to re...

  1. Claudia Bruns: Politik des Eros. Der Männerbund in Wissenschaft, Politik und Jugendkultur (1880–1934. Köln u.a.: Böhlau Verlag 2008.

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    Stefan Müller

    2009-11-01

    Full Text Available Quer zur Standardrezeption analysiert Claudia Bruns in ihrer Dissertation Blühers Konzeption von Mann, Männlichkeit und mann-männlicher Beziehung unter besonderer Berücksichtigung damit einhergehender Ausschlüsse. Zentral legt sie das Konzept des Männerbundes zugrunde, das den Dreh- und Angelpunkt der vorliegenden Untersuchung bildet, und zieht die Theorien Blühers als paradigmatisches Beispiel dafür heran. Dieses Vorgehen ist aus verschiedenen Gründen klug gewählt und vorteilhaft. Bislang ist kaum der ideologisch vielschichtige Gehalt von Diskussionen, wie sie Blüher führte und führen konnte, in die Geschichts- und Gesellschaftswissenschaften eingegangen. Zudem gab es bislang kein Gesamtverzeichnis der Schriften Blühers, wodurch die Rezeption erschwert wurde, und das sich nun im Anhang der Arbeit dankenswerterweise findet.In her dissertation, Claudia Bruns analyses Blüher’s concept of man, masculinity, and male-male-relationships with specific attention to that which is excluded, thus going against its standard reception. She places the concept of the male society central to the examination and it becomes the pivot around which the study is created. She does so by consulting the theories of Blüher as a paradigmatic example. This is a very astute and advantageous choice for many reasons. To date the ideologically multilayered content of Blüher’s actual and possible discussions has barely been inserted into discourse in history and the social sciences. Additionally, a comprehensive catalogue of Blüher’s writings has yet to be produced, which impedes its reception. This has now thankfully been rectified in the form of an appendix to this study.

  2. Formas de ocio en la antigua Roma: desde la dinastía Julio-Claudia (Octavio Augusto hasta la Flavia (Tito Flavio Domiciano

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    Maximiliano Korstanje

    2008-01-01

    Full Text Available Basados en una mitología netamente política (helénica y poseedores de recursos estratégicos favorables, los romanos se convirtieron en una de las civilizaciones dominantes de su tiempo. En este sentido, muchos investigadores dedicados al turismo, actualmente, han investigado los orígenes y las formas de ocio en la antigua Roma, aunque de manera superficial y muy general. El objetivo del presente trabajo es profundizar sobre las formas de ocio en la Roma Imperial durante las dinastías Julio-Claudia y Flavia, para así poder explicar cuál era la relación del ocio, como institución, con el poder político de la época.

  3. Towards a reconstruction of the contributions of the Argentine experience to the development of International Human Rights Law: the voices of Claudia Fontes and Paula Bombara

    Directory of Open Access Journals (Sweden)

    Estefanía Giaccone

    2017-12-01

    Full Text Available In the present dissertation, we intend to relate and contrast the representations that emerge from legal and political-institutional discourses on the crime of forced disappearance of persons in the Argentinian historical experience. In this sense, we will analyze the representations of the crime of forced disappearance of persons in two artistic works: The Reconstruction of Pablo Miguez Portrait, Claudia Fontes’ sculpture, and The Sea and the Serpent, a novel by Paula Bombara, in order to read them into the perspective of law, with the jurisprudence and communications of international organizations that shape our unit of study.

  4. ¿Nuevos sujetos subalternos? ¡No en la nación cercada! Del “Informe sobre Uchuraccay” de Mario Vargas Llosa a Madeinusa de Claudia Llosa

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    Juan Carlos Ubilluz Raygada

    2014-06-01

    Full Text Available Madeinusa (2006, la ópera prima de Claudia Llosa, es una de las películas peruanas más exitosas en el exterior; ha ganado festivales de cine en Europa y Estados Unidos. Pero también es la película que ha suscitado uno de los debates más candentes en el medio nacional. El debate gira en torno a la representación del mundo andino y de sus habitantes. A fin de entender el porqué de su carácter encendido, dediquemos de entrada algunas líneas al espacio y al tiempo de la película.

  5. Claudia Demattè and Alberto del Río, Parodia de la materia caballeresca y teatro áureo. Edición de Las aventuras de Grecia y su modelo serio, el «Don Florisel de Niquea» de Montalbán

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    Javier Guijarro Ceballos

    2015-01-01

    Full Text Available Review of Claudia Demattè and Alberto del Río, Parodia de la materia caballeresca y teatro áureo. Edición de Las aventuras de Grecia y su modelo serio, el «Don Florisel de Niquea» de Montalbán, Servicio de Publicaciones de la Universidad de Navarra (Publicaciones digitales del GRISO, Pamplona, 2012, 247 pp. ISBN: 9788480813365.

  6. Los terremotos antiguos del conjunto arqueológico romano de Baelo Claudia (Cádiz, Sur de España: Quince años de investigación arqueosismológica

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    Silva, P. G.

    2016-06-01

    Full Text Available This work illustrates the state of the art on archaeoseismology of the ancient Roman city of Baelo Claudia (Tarifa, Cádiz after nearly fifteen years of research. This ancient Roman site was affected by two earthquakes in the years AD 40–60 and AD 260–290 which promoted important urban and architectural changes and eventually the destruction and further abandonment of the city in AD 365–390. Earthquake Archaeoseismological Effects (EAEs are catalogued, described and mapped in the entire monumental sector of the city mainly witnessing the last earthquake which occurred in AD 260–290. Mapping of oriented EAEs illustrate damage distribution all over the lower sector of the city, as well as the occurrence of suspect coseismic landslide and tsunami events. The structural analysis of oriented EAEs throughout the entire mapped sector suggests that the intervening ground motion was preferentially oriented in a SW to NE direction. The geoarchaeological analysis and some relevant archaeological anomalies, strongly suggest the occurrence of coeval tsunami events during both ancient earthquakes, pointing to the occurrence of an offshore seismic source SSW of the city. Several N-S normal faults have been identified around the Bolonia Bay area and some of them continue offshore SSW of Baelo Claudia. These faults with clear Quaternary activity can be considered as the more probable seismic sources for the events affecting the ancient Roman site and they are consistent with the mapped damage orientation displayed by the structural analysis of EAEs within the old Roman city.El presente trabajo ilustra el estado del conocimiento sobre arqueosismología en la antigua ciudad romana de Baelo Claudia (Tarifa, Cádiz tras casi quince años de investigaciones. Esta antigua ciudad romana se vio afectada por dos importantes terremotos en los años 40–60 AD y 260–290 AD. El primero de ellos afectó en mayor grado a la parte baja (costera de la ciudad

  7. Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia.

    Science.gov (United States)

    Opoka, Robert O; Ndugwa, Christopher M; Latham, Teresa S; Lane, Adam; Hume, Heather A; Kasirye, Phillip; Hodges, James S; Ware, Russell E; John, Chandy C

    2017-12-14

    Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown. In vitro studies suggest hydroxyurea could increase malaria severity, and hydroxyurea-associated neutropenia could worsen infections. NOHARM (Novel use Of Hydroxyurea in an African Region with Malaria) was a randomized, double-blinded, placebo-controlled trial conducted in malaria-endemic Uganda, comparing hydroxyurea to placebo at 20 ± 2.5 mg/kg per day for 12 months. The primary outcome was incidence of clinical malaria. Secondary outcomes included SCA-related adverse events (AEs), clinical and laboratory effects, and hematological toxicities. Children received either hydroxyurea (N = 104) or placebo (N = 103). Malaria incidence did not differ between children on hydroxyurea (0.05 episodes per child per year; 95% confidence interval [0.02, 0.13]) vs placebo (0.07 episodes per child per year [0.03, 0.16]); the hydroxyurea/placebo malaria incidence rate ratio was 0.7 ([0.2, 2.7]; P = .61). Time to infection also did not differ significantly between treatment arms. A composite SCA-related clinical outcome (vaso-occlusive painful crisis, dactylitis, acute chest syndrome, splenic sequestration, or blood transfusion) was less frequent with hydroxyurea (45%) than placebo (69%; P = .001). Children receiving hydroxyurea had significantly increased hemoglobin concentration and fetal hemoglobin, with decreased leukocytes and reticulocytes. Serious AEs, sepsis episodes, and dose-limiting toxicities were similar between treatment arms. Three deaths occurred (2 hydroxyurea, 1 placebo, and none from malaria). Hydroxyurea treatment appears safe for children with SCA living in malaria-endemic sub-Saharan Africa, without increased severe malaria, infections, or AEs. Hydroxyurea provides SCA-related laboratory and clinical

  8. The Exploitation of the Electric Contributions in Infrared Power Generation

    Science.gov (United States)

    2016-02-02

    temperature, i.e., cook food and heat-up beverages . Similarly, through laser radiation it is possible to increase temperature, even with na...2015. [13] C.-P. Richter, S. Rajguru, R. Stafford, and S. R. Stock, Radiant energy during infrared neural stimulation at the target structure, Proc...Currie). -> Lodging and food for G. Scarel’s travel to NRL on August 17-19, 2015: $ 655.82 (•) Miscellaneous: —> Bruker HeNe laser module to support

  9. Introduction: Information and Musings

    Science.gov (United States)

    Shifman, M.

    The following sections are included: * Victor Frenkel * Background * The Accused * Alexander Leipunsky * Alexander Weissberg * Holodomor * The beginning of the Great Purge * Other foreigners at UPTI * The Ruhemanns * Tisza * Lange * Weisselberg * A detective story * Stalin's order * Yuri Raniuk * Giovanna Fjelstad * Giovanna's story * First time in the USSR * Fisl's humor * Houtermans and Pomeranchuk * Choices to make * Closing gaps * Houtermans and the Communist Party of Germany * Houtermans and von Ardenne * Houtermans' trip to Russia in 1941 * Why Houtermans had to flee from Berlin in 1945 * Houtermans in Göttingen in the 1940's * Denazification * Moving to Bern * Yuri Golfand, the discoverer of supersymmetry * Bolotovsky's and Eskin's essays * Moisei Koretz * FIAN * Additional recommended literature * References

  10. Review: Tasos Zembylas & Claudia Dürr (2009. Wissen, Können und literarisches Schreiben. Eine Epistemologie der künstlerischen Praxis [Knowledge, Mastery, and literate Writing. An Epistemology of Artistic Practice

    Directory of Open Access Journals (Sweden)

    Stefan Fothe

    2010-08-01

    Full Text Available Tasos ZEMBYLAS and Claudia DÜRR trace the emergence of prose texts. By analyzing three case studies of young writers, they map a central domain of artistic practice. Their particular focus is on practical knowledge, which they assume to be highly important. However, as it is intimately intermingled with relevant performance, its empirical "capture" is both challenging and attracting. Practical knowledge is often not only implicit, but does not share many of the characteristics of propositional knowledge. The authors reconstruct its relevance, externalization and nature, as well as its individual and cultural shape. This paper focuses on the analysis of the study's theoretical background, the so-called Tacit Knowing View. After an introduction, this framework is applied onto itself. Hence, it can be asked if practical knowledge—as conceptualized within this view—can be empirically captured. It is only then that the study of ZEMBYLAS and DÜRR can be properly valued. The conclusion is drawn that their book represents an important first step on a longer road towards the intended epistemology of artistic practice. Based upon the Tacit Knowing View framework, further steps along this road are suggested. URN: urn:nbn:de:0114-fqs1003298

  11. Rezension von: Thomas Martinec, Claudia Nitschke (Hg.: Familie und Identität in der deutschen Literatur. Frankfurt am Main u.a.: Peter Lang Verlag 2009. — Ariane Eichenberg: Familie – Ich – Nation. Göttingen: V&R unipress 2009.

    Directory of Open Access Journals (Sweden)

    Christine Kanz

    2010-06-01

    Full Text Available Die Themen Generation und Familie gehören zu den wichtigsten Sujets literarischer Texte, insbesondere wenn diese die Herausbildung oder die Zerstörung von Identität problematisieren. Ein neuer, von Claudia Nitschke und Thomas Martinec herausgegebener Tagungsband ist der literatur- und kulturwissenschaftlichen Auseinandersetzung mit diesen Themen gewidmet. Sechs Jahrzehnte nach dem Ende des Zweiten Weltkrieges hat vor allem das Genre des Generationenromans Hochkonjunktur, insbesondere Texte der dritten Generation zum Umgang der Großeltern-Generation mit dem Nationalsozialismus. Den Verfasser/-innen dieses neuen, in sich heterogenen Genres wird in der Studie von Ariane Eichenberg allerdings keine allzu große Wirkmächtigkeit bescheinigt. Im Gegenteil nährten die modischen Texte mit den Funden aus der Vergangenheit vor allem das Ich der Erzähler/-innen, deren eigene Gefühle und Selbstvergewisserung in einer von Unsicherheiten geprägten Gegenwart.

  12. Modern Milano. A survey about transformation of architectural and urban heritage

    Directory of Open Access Journals (Sweden)

    Giovanna D’Amia

    2009-12-01

    Full Text Available The XX Century Milan estate of buildings records the renovation of the culture and the predominance of the Rationalism between the World Wars and the Second postwar. Nevertheless, it is still unknown and poorly documented and it has often suffered radical transformations. Giovanna D’Amia and Luca Tamini formulated an hypothesis of an observatory of the Modern Milan as an interdisciplinary research to deeply know and valorise this estate of buildings, to survey their conditions and to propose guidelines for future interventions. An archive of data and graphic documents of 45 selected buildings has been created by Giovanna D’Amia Course of Contemporary History of Architecture (year 2008/2009 in order to verify the fairness of this approach. Nowadays it is possible to drew up a first balance of the research.

  13. Crescere errando: minori immigrati non accompagnati" (Clara Silva - Giovanna Campani

    Directory of Open Access Journals (Sweden)

    Olivia Salimbeni

    2005-12-01

    Full Text Available La presenza in Italia di minori immigrati non accompagnati è un fenomeno recente e tuttavia in forte crescita. Questo testo raccoglie i risultati di quella che potremmo definire la seconda di tre tappe di una ricerca europea incentrata sullo studio del fenomeno dei minori immigrati non accompagnati, avviata nel 2000 e da poco terminata. L’indagine è stata svolta nel quadro di finanziamento del 'Programma Daphne' della Commissione Europea e ha riguardato nelle prime due fasi tre realtà europee, Italia, Germania e Finlandia e nella terza altre realtà quali il Portogallo, la Spagna, la Francia e la Grecia.

  14. Il ‘volto’ dei libri: Analisi ed evoluzione delle copertine, nell’epoca d’oro dell’editoria italiana

    Directory of Open Access Journals (Sweden)

    Ottavio Sellitti

    2014-12-01

    Full Text Available Recensione di: Giovanna Zaganelli (a cura di, Letteratura in copertina: Collane di narrativa in biblioteca tra il 1950 e il 1980, Bologna, Logo Fausto Lupetti editore, 2013, 176 p., ISBN: 9788895962986, € 24,00.

  15. On Framing

    DEFF Research Database (Denmark)

    Peder Pedersen, Claus

    2018-01-01

    On framing as artistic and conceptual tool in the works of Claudia Carbone. Contribution to exhibition at the Aarhus School of Architecture.......On framing as artistic and conceptual tool in the works of Claudia Carbone. Contribution to exhibition at the Aarhus School of Architecture....

  16. Veneetsia filmifestival ilmutas auhindu jagades tolerantsi / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2005-01-01

    62. Veneetsia filmifestivali auhinnasaajad. Parima filmi Kuldlõvi sai Ang Lee "Brokebacki mägi", žürii eripreemia Abel Ferrara (artiklis "Ferrera") "Mary", parimaks naisnäitlejaks tituleeriti Giovanna Mezzogiorno, Marcello Mastroianni nimelise noore näitleja preemia sai Menothy Cesar

  17. The Impact of Different Support Vectors on GOSAT-2 CAI-2 L2 Cloud Discrimination

    Directory of Open Access Journals (Sweden)

    Yu Oishi

    2017-11-01

    Full Text Available Greenhouse gases Observing SATellite-2 (GOSAT-2 will be launched in fiscal year 2018. GOSAT-2 will be equipped with two sensors: the Thermal and Near-infrared Sensor for Carbon Observation (TANSO-Fourier Transform Spectrometer 2 (FTS-2 and the TANSO-Cloud and Aerosol Imager 2 (CAI-2. CAI-2 is a push-broom imaging sensor that has forward- and backward-looking bands to observe the optical properties of aerosols and clouds and to monitor the status of urban air pollution and transboundary air pollution over oceans, such as PM2.5 (particles less than 2.5 micrometers in diameter. CAI-2 has important applications for cloud discrimination in each direction. The Cloud and Aerosol Unbiased Decision Intellectual Algorithm (CLAUDIA1, which applies sequential threshold tests to features is used for GOSAT CAI L2 cloud flag processing. If CLAUDIA1 is used with CAI-2, it is necessary to optimize the thresholds in accordance with CAI-2. However, CLAUDIA3 with support vector machines (SVM, a supervised pattern recognition method, was developed, and then we applied CLAUDIA3 for GOSAT-2 CAI-2 L2 cloud discrimination processing. Thus, CLAUDIA3 can automatically find the optimized boundary between clear and cloudy areas. Improvements in CLAUDIA3 using CAI (CLAUDIA3-CAI continue to be made. In this study, we examined the impact of various support vectors (SV on GOSAT-2 CAI-2 L2 cloud discrimination by analyzing (1 the impact of the choice of different time periods for the training data and (2 the impact of different generation procedures for SV on the cloud discrimination efficiency. To generate SV for CLAUDIA3-CAI from MODIS data, there are two times at which features are extracted, corresponding to CAI bands. One procedure is equivalent to generating SV using CAI data. Another procedure generates SV for MODIS cloud discrimination at the beginning, and then extracts decision function, thresholds, and SV corresponding to CAI bands. Our results indicated the following

  18. Indian Academy of Sciences Conference Series | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Indian Academy of Sciences Conference Series. GIOVANNA ZIMATORE. Articles written in Indian Academy of Sciences Conference Series. Volume 1 Issue 1 December 2017 pp 35-41 Proceedings of the Conference on Perspectives in Nonlinear Dynamics - 2016. RQA correlations on real business cycles ...

  19. Masculinidades subversivas nos romances de Manuel Puig, Caio Fernando Abreu e Jaime Bayly

    Directory of Open Access Journals (Sweden)

    Oswaldo Alves Lara Neto

    2014-05-01

    Full Text Available Produção: Claudia Priscilla e Pedro Marques. Vestido de Laerte. São Paulo: Paleo TV, 2012. 1 HDCAM.   Produção: Claudia Priscilla e Kiko Goifman. Olhe para mim de novo. São Paulo: Paleo TV, 2011. 1 HDCAM

  20. Understanding Girls' Circle as an Intervention on Perceived Social Support, Body Image, Self-Efficacy, Locus of Control, and Self-Esteem

    Science.gov (United States)

    Steese, Stephanie; Dollette, Maya; Phillips, William; Hossfeld, Elizabeth; Matthews, Gail; Taormina, Giovanna

    2006-01-01

    The Girls' Circle is a support group for adolescent girls developed by Beth Hossfeld and Giovanna Taormina as a unique program that addresses the needs of girls by focusing on increasing connections, building empathic skills, and developing resiliency. The present study evaluates the effectiveness of the Girls' Circle intervention on improving…

  1. Method for validating cloud mask obtained from satellite measurements using ground-based sky camera.

    Science.gov (United States)

    Letu, Husi; Nagao, Takashi M; Nakajima, Takashi Y; Matsumae, Yoshiaki

    2014-11-01

    Error propagation in Earth's atmospheric, oceanic, and land surface parameters of the satellite products caused by misclassification of the cloud mask is a critical issue for improving the accuracy of satellite products. Thus, characterizing the accuracy of the cloud mask is important for investigating the influence of the cloud mask on satellite products. In this study, we proposed a method for validating multiwavelength satellite data derived cloud masks using ground-based sky camera (GSC) data. First, a cloud cover algorithm for GSC data has been developed using sky index and bright index. Then, Moderate Resolution Imaging Spectroradiometer (MODIS) satellite data derived cloud masks by two cloud-screening algorithms (i.e., MOD35 and CLAUDIA) were validated using the GSC cloud mask. The results indicate that MOD35 is likely to classify ambiguous pixels as "cloudy," whereas CLAUDIA is likely to classify them as "clear." Furthermore, the influence of error propagations caused by misclassification of the MOD35 and CLAUDIA cloud masks on MODIS derived reflectance, brightness temperature, and normalized difference vegetation index (NDVI) in clear and cloudy pixels was investigated using sky camera data. It shows that the influence of the error propagation by the MOD35 cloud mask on the MODIS derived monthly mean reflectance, brightness temperature, and NDVI for clear pixels is significantly smaller than for the CLAUDIA cloud mask; the influence of the error propagation by the CLAUDIA cloud mask on MODIS derived monthly mean cloud products for cloudy pixels is significantly smaller than that by the MOD35 cloud mask.

  2. Unustatud katakombid / Claudia Haj Ali

    Index Scriptorium Estoniae

    Haj Ali, Claudia

    1999-01-01

    Arheoloog Jean-Yves Empereur leidis Egiptuse Aleksandria linna lähedal asuvasse kaljusse rajatud katakombid, mis on osa hellenistlikul perioodil rajatud ning pikka aega unustuse hõlmas olnud surnute linnast. Leidude seas on kipsist Meduusa pea nind leide Rooma perioodist.

  3. Comentarios sobre las atribuciones a Sofonisba Anguissola por el Doctor Alfio Nicotra

    Directory of Open Access Journals (Sweden)

    Kusche, Maria

    2009-09-01

    Full Text Available At a meeting concerning Sofonisba Anguissola in Palermo (February 2008, the physician and art collector Dr. Alfio Nicotra (Catania, Sicily proposed several new attributions to the artist. Four of them are totally convincing and they are here integrated into Sofonisba’s oeuvre: La Madonna dell’ Itría, an image dedicated to the memory of Fabricio de Moncada, Anguissola’s husband; and portraits of Giovanna de Austria (daughter of Don Juan de Austria; Margarita de Saboya; and a Lateran Canon.

    El médico y coleccionista siciliano Dr. Alfio Nicotra, residente en Catania, Sicilia, presentó en un acto en honor a Sofonisba Anguissola, en Palermo en 2008, una serie de atribuciones a la pintora. Al parecerme acertadas las siguientes, aquí se intenta situarlas en su obra, que de este modo se ve considerablemente ampliada. Se trata de una imagen en memoria del marido de la pintora, Don Fabricio de Monacada, un retrato de Giovanna de Austria –hija de Don Juan de Austria–, uno de Margarita de Saboya y uno de un Canónigo Lateranense.

  4. Reducing Electromagnetic Interference in a Grid Tied Single Phase Power Inverter

    Science.gov (United States)

    2016-09-01

    With the growing demand for a reliable electrical grid, backup power supplies and energy management systems are a necessity. Systems such as server...ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER INVERTER by Jason Hassan Valiani September 2016 Thesis Advisor: Giovanna Oriti...3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE REDUCING ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER

  5. Publisher Correction

    DEFF Research Database (Denmark)

    Bonàs-Guarch, Sílvia; Guindo-Martínez, Marta; Miguel-Escalada, Irene

    2018-01-01

    In the originally published version of this Article, the affiliation details for Santi González, Jian'an Luan and Claudia Langenberg were inadvertently omitted. Santi González should have been affiliated with 'Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computatio......In the originally published version of this Article, the affiliation details for Santi González, Jian'an Luan and Claudia Langenberg were inadvertently omitted. Santi González should have been affiliated with 'Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program...

  6. Acting Globally: Cultivating a thousand community solutions for climate justice

    OpenAIRE

    Giovanna Di Chiro

    2011-01-01

    Giovanna Di Chiro is Director of Environmental Programs at Nuestras Raíces, Inc. and Research Associate at the Five College Women's Studies Research Center. She has published widely on the intersections of race, gender, and environmental justice with a focus on women's activism and policy change addressing environmental health disparities in lower income communities. She is completing a book Embodied Ecologies: Science, Politics, and Environmental Justice. Her current work examines environmen...

  7. Der Terminator und die Femme fatale. Gender im Genre-Kino The Terminator and the Femme Fatale: Gender in Genre Cinema

    Directory of Open Access Journals (Sweden)

    Rochus Wolff

    2005-03-01

    Full Text Available Mit Hollywood hybrid legen Claudia Liebrand und Ines Steiner einen äußerst lesenswerten Sammelband vor, in dem aus unterschiedlichen Blickwinkeln Hollywoodfilme der vergangenen Jahre untersucht wurden. Im Zentrum stehen dabei stets die komplexen Wechselwirkungen zwischen Genre und Gender. Von wenigen Schwächen abgesehen, gelingen den Autor/-innen dabei durchweg überzeugende Analysen.Claudia Liesbrand and Ines Steiner’s very worth reading Hollywood hybrid is a collected volume in which Hollywood films of recent years are examined from various angles. Central to the text is the continually complex interaction between genre and gender. With this, the authors enjoy, a few weaknesses aside, ongoing success.

  8. Jaan Ruus uues Berliinis / Jaan Ruus

    Index Scriptorium Estoniae

    Ruus, Jaan, 1938-2017

    2002-01-01

    Berliini 52. filmifestivalist. Festivali avafilmist - sakslase T. Tykweri "Taevas" ("Heaven") ja elutöö auhinna saanud Claudia Cardinalest ning Robert Altmanist, samuti vastuvõtust Eesti saatkonnas

  9. Eesti turvafirmade vappe

    Index Scriptorium Estoniae

    1998-01-01

    Firmad: AS ESS, Viking Valve, Barracuda Turvakaitse AS, Barbaros, Akropol A AS, AS Claudia Turvasüsteemid, ESSEC Security, AS Tammiskilp, Eesti Turvateenistuse AS (ESC), Scorpioni Julgestusteenistuse AS

  10. Will Instructors Save Time Using a Specifications Grading System?

    Directory of Open Access Journals (Sweden)

    Sarah Grace Prescott

    2015-08-01

    Full Text Available Review of: Specifications Grading: Restoring Rigor, Motivating Students, and Saving Faculty Time; Linda Nilson and Claudia J. Stranny; (2014. Stylus Publishing, Sterling, VA. 184 pages.

  11. Zur historischen Aufarbeitung und medialen Vermittlung der Shoah in Italien und Deutschland

    Directory of Open Access Journals (Sweden)

    Peter Kuon

    2016-03-01

    Full Text Available Claudia Müller, Patrick Ostermann und Karl-Siegbert Rehberg, Hrsg., Die Shoah in Geschichte und Erinnerung: Perspektiven medialer Vermittlung in Italien und Deutschland (Bielefeld: transcript, 2015.

  12. Linna luksuslik liider / Lea Veelma

    Index Scriptorium Estoniae

    Veelma, Lea, 1947-2007

    2006-01-01

    Tallinna vanalinnas asuv Schlössle Hotell arvati ametlikult ülemaailmse luksushotellide keti The Leading Hotels of the World (LHW) liikmeks. Sündmuse puhul viibis Tallinnas LHW asepresident Claudia Roth

  13. assessment of socio-economic characteristics of community based

    African Journals Online (AJOL)

    GRACE

    Keywords: Socio-cultural, Characteristics, Neighbours, Festivals, Community, ... diffusion of power through a wider circle of population (Claudia, 2003; Nallari .... growth to conquer material poverty; the corrupt theory, which recognizes that ...

  14. Modelliagentuurid toodavad Carmen Kassile tasemel järglasi / Kerli Nõu

    Index Scriptorium Estoniae

    Nõu, Kerli

    2006-01-01

    Eestis tegutsevatest modelliagentuuridest Beatrice Mass Modelnet, Baltic Models OÜ ja Eesti Modelliagentuuri OÜ. Kommentaarid: Tasane algus kulisside taga, Edukad Eesti modellid (Annika Vohta), Eesti uus Carmen Kass (Claudia Meriküla)

  15. Antineoplastic-related cardiotoxicity, morphofunctional aspects in a murine model: contribution of the new tool 2D-speckle tracking

    Directory of Open Access Journals (Sweden)

    Coppola C

    2016-11-01

    Full Text Available Carmela Coppola,1 Gennaro Riccio,1 Antonio Barbieri,2 Maria Gaia Monti,3 Giovanna Piscopo,1 Domenica Rea,2 Claudio Arra,2 Carlo Maurea,1 Claudia De Lorenzo,4,5 Nicola Maurea1 1Division of Cardiology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 2Animal Facility Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 3Department of Translational Medical Sciences, University Federico II, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology, University Federico II, Naples, Italy; 5CEINGE Biotecnologie Avanzate, Naples, Italy Objective: Considering that global left ventricular systolic radial strain is a sensitive technique for the early detection of left ventricular dysfunction due to antineoplastics and the analysis of segmental myocardial contractility, we evaluated this technique for early detection of trastuzumab-related cardiotoxicity by comparing it with cardiac structural damage.Methods: Groups of six mice were injected with trastuzumab or doxorubicin, used either as single agents or in combination. Cardiac function was evaluated by transthoracic echocardiography measurements before and after treatment for 2 or 7 days, by using a Vevo 2100 high-resolution imaging system. After echocardiography, mice were euthanized, and hearts were processed for histological evaluations, such as cardiac fibrosis, apoptosis, capillary density, and inflammatory response.Results: Trastuzumab-related cardiotoxicity was detected early by 2D strain imaging. Radial strain was reduced after 2 days in mice treated with trastuzumab alone (21.2%±8.0% vs 40.5%±4.8% sham; P<0.01. Similarly, trastuzumab was found to induce apoptosis, capillary density reduction, and inflammatory response in cardiac tissue after 2 days of treatment, in a fashion similar to doxorubicin. On the contrary, fractional

  16. PWMScan: a fast tool for scanning entire genomes with a position-specific weight matrix.

    Science.gov (United States)

    Ambrosini, Giovanna; Groux, Romain; Bucher, Philipp

    2018-03-05

    Transcription factors (TFs) regulate gene expression by binding to specific short DNA sequences of 5 to 20-bp to regulate the rate of transcription of genetic information from DNA to messenger RNA. We present PWMScan, a fast web-based tool to scan server-resident genomes for matches to a user-supplied PWM or TF binding site model from a public database. The web server and source code are available at http://ccg.vital-it.ch/pwmscan and https://sourceforge.net/projects/pwmscan, respectively. giovanna.ambrosini@epfl.ch. SUPPLEMENTARY DATA ARE AVAILABLE AT BIOINFORMATICS ONLINE.

  17. Storia, precariato e criminalità. La narrativa italiana racconta la politica contemporanea

    Directory of Open Access Journals (Sweden)

    Paolo Chirumbolo

    2015-07-01

    Full Text Available Recensione di: Claudia Boscolo e Stefano Jossa (a cura di, Scritture di resistenza. Sguardi politici dalla narrativa italiana contemporanea, Roma, Carocci Editore, 2014, 204 p. ISBN: 9788843074143, € 16,00.

  18. Tants ei küsi vanust / Ille Grün-Ots, Siiri Rebane

    Index Scriptorium Estoniae

    Grün-Ots, Ille, 1960-2016

    2007-01-01

    Kanal 2 menusaate "Tantsud tähtedega" järellainetuses vesteldakse artiklis seltskonnatantsust Revalia tantsukooli juhataja Merle Klandorfiga, bailatinost Dance Act direktori Georg Kodusaarega, kõhutantsust tantsuõpetaja Diana Otsinguga ja flamenkost Claudia Shevsthenkoga

  19. Costs for Hospital Stays in the United States, 2011

    Science.gov (United States)

    ... Lauren M. Wier, M.P.H., and Claudia Steiner, M.D., M.P.H. Introduction Health care ... Truven Health Analytics), Wier, LM (Truven Health Analytics), Steiner, C (AHRQ). Costs for Hospital Stays in the ...

  20. American Pain Society

    Science.gov (United States)

    ... Christopher King Jennifer Lee Kimberly Sibille Shivani Ruparel Steve Davidson Claudia Campbell Jennifer DeBerry Tim Doyle Adam ... Resources Early Career Advisory Group Members Early Career Job Board ECAG Application About Us Who's Who in ...

  1. USA kunstnike loengud Kunstiakadeemias

    Index Scriptorium Estoniae

    2004-01-01

    20. jaanuaril on Claudia DeMonte Tallinna Kunstihoones toimuva näituse "Women of the World" tausta avav loeng ja Ed McGowini loeng kaasaegsest rahvakunstist, 21. jaanuaril räägivad mõlemad kunstnikud oma loometegevusest

  2. Kunstnikud käivad katuseid mööda / Hanno Soans

    Index Scriptorium Estoniae

    Soans, Hanno, 1974-

    2010-01-01

    Näitus "Linna kohal" Tallinna Linnagaleriis 19. septembrini 2010. Osalevad Anu Vahtra, Johnson & Johnson, Timo Toots, Claudia Doms, Mikk Heinsoo, Urmo Mets, Marit Ilison. Kuraatorid Kadri Klementi ja Helis Teiter. Näituse teemaks on linnamajade kasutamata katusepinnad

  3. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... for PD Patients? Are There Any Ways to Control the Rate of Progression of the Disease? What ... 2 What Are Some Strategies to Improve the Quality of Community Care for PD Patients? Dra. Claudia ...

  4. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Does a Caregiver Need to Know About Cognitive Impairment? Dra. Claudia Martinez, MAPC - Parkinson- Pasion, Positivismo y ... Beyond This Life What Medications Help with Cognitive Impairment? What Are Some Tips for Following a Medication ...

  5. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Diagnosis PD, Now What? Managing the First Few Years with Parkinson's Expert Briefings: Pain in PD Expert ... Salud en General, Parte 2 CareMAP: Life Beyond This Life Dra. Claudia Martinez, MAPC - Parkinson- Pasion, Positivismo ...

  6. Men and islands. The great blue road

    Directory of Open Access Journals (Sweden)

    Paolino Nappi

    2016-07-01

    Full Text Available Gillo Pontecorvo’s feature breakthrough is the adaptation of Franco Solinas’ short novel Squarciò, focused on the life of a lonely fisherman who uses bombs as wells as fishnets, endangering his life every day. After the first approach with Giovanna, the relationship between the director and his customary screenwriter sharpens. Some casting issue: the actors do not satisfy Pontecorvo, because their physiognomy doesn’t match with those of the characters. The importance of sea landscape into the mise-en-scene’s building. The expressive use of sound. The political meaning: individualism against work’s collectivization

  7. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... el Comportamiento, Parte 1 CareMAP: Medicamentos y la Salud en General, Parte 1 Expert Briefings: Apathy or ... Caregiving Hallucinations and Delusions CareMAP: Medicamentos y la Salud en General, Parte 2 Dra. Claudia Martinez, MAPC - ...

  8. Flawed but fair: Brazil’s health system reaches out to the poor

    OpenAIRE

    2008-01-01

    Despite its many problems, Brazil’s revamped public health system has brought quality health care to millions of poorer inhabitants who were previously denied even basic care. Claudia Jurberg reports on how primary health care is playing an essential role.

  9. 21. sajandi organisatsioon / Vello Rääk

    Index Scriptorium Estoniae

    Rääk, Vello

    2006-01-01

    Mõtteid McKinsey konsultantide Lowell L. Bryan ja Claudia Joyce väljaandes McKinsey Quarterly, 2005, nr. 3 ilmunud artiklist "The 21st Century Organization", mis käsitleb teadmustöötajate produktiivsuse olukorda ning selle tõstmist

  10. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... el Comportamiento, Parte 1 CareMAP: Medicamentos y la Salud en General, Parte 1 Expert Briefings: Apathy or ... CareMAP: Caring from Afar CareMAP: Medicamentos y la Salud en General, Parte 2 Dra. Claudia Martinez, MAPC - ...

  11. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... How Is Parkinson's Disease Diagnosed? CareMAP: Managing Caregiver Stress CareMAP: Getting Dressed CareMAP: End-of-Life Care ... Salud en General, Parte 2 CareMAP: Rest and Sleep: Part 2 Dra. Claudia Martinez, MAPC - Parkinson- Pasion, ...

  12. African Journal of Biotechnology - Vol 15, No 25 (2016)

    African Journals Online (AJOL)

    Micropropagation of Handroanthus heptaphyllus (Vell.) Mattos from seedling explants · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Evelyn Duarte, Pedro Sansberro, Claudia Luna, 1292-1298. http://dx.doi.org/10.5897/AJB2015.15194 ...

  13. Micropropagation of Handroanthus heptaphyllus (Vell.) Mattos from ...

    African Journals Online (AJOL)

    Micropropagation of Handroanthus heptaphyllus (Vell.) Mattos from seedling explants. Evelyn Duarte, Pedro Sansberro, Claudia Luna. Abstract. Handroanthus heptaphyllus (Vell.) Mattos (Bignoniaceae), a tropical forest tree, is a source of wood suitable for the manufacture of fine furniture and chemical compounds with ...

  14. Molecular genetic study of hemophilia B in an Algerian population

    African Journals Online (AJOL)

    DELL

    2016-12-21

    Dec 21, 2016 ... linked recessive bleeding disorder of coagulation caused by mutation in ... is in close correlation with the type and position of the mutation in FIX ..... Ana RJ, Claudia PB, Isaura AG, José de Jesús LJ, Hilda LZ, Johanna. MMC ...

  15. Wellness expectations within a telecommunications organisation / Claudia Sofia Sacks

    OpenAIRE

    Sacks, Claudia Sofia

    2012-01-01

    Wellness is becoming popular as the human factor is realised in terms of empowering employees to perform through wellness initiatives and in the long-term gaining financial success of an organisation. Wellness is bound to be of growing importance in the future, as it is a business prerequisite and has far greater significance for the organisation, employee’s managers and society as a whole. The real challenge is implementation of wellness initiatives and to gain employee and management partic...

  16. Neue Generation, neue Medien und eine neue Bildung?

    NARCIS (Netherlands)

    Bastiaens, Theo; Schrader, Claudia

    2018-01-01

    Extract Neue Generation, neue Medien und eine neue Bildung? Theo Bastiaens & Claudia Schrader Abstract This chapter focuses on the question of what influence societal changes have on learners, their learning behavior and the curriculum. Fact is that there has been one major change with an

  17. Homenagem a colette pétonnet

    Directory of Open Access Journals (Sweden)

    Claudia Fonseca

    2014-06-01

    Full Text Available O seminário "Les sentiers de l'ethnologie urbaine, avec Colette Pétonnet" ("Pistas da etnologia urbana, com Colette Petonnet", realizado entre 3 e 4 de outubro de 2013, no Muséum National d'Histoire Naturelle - Paris, reuniu diversos pesquisadores para uma homenagem póstuma a esta precursora da etnologia em meio urbano, fundadora, com Jacques Gutwirth, do Laboratoire d'Anthropologie Urbaine do Centre National de Recherche Scientifique (LAU/CNRS. Este artigo é uma tradução do paper enviado por Claudia Fonseca, ex-orientanda da homenageada, apresentado, na ocasião, em forma de um vídeo, produzido em conjunto com Claudia Turra Magni e Mauro Bruschi, sob o título Colette Pétonnet au Brésil: les effets pédagogiques d'un exercice ethnographique. Aqui, as autoras evocam as marcas e repercussões dos ensinamentos da mestra, a partir de sua estada no Brasil, na última década do século passado.

  18. A Hermeneutic Phenomenological Approach to Understanding ...

    African Journals Online (AJOL)

    User

    focus in a new way, it enables us to glimpse the phenomenon anew, with the prospect of .... three girls (Claudia, Sarah and Kamille) and three ... were registered in the enriched school programme. .... phenomenological dynamic offers an original and ..... is a registered nurse and Professor in the Department of Education,.

  19. 78 FR 68151 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2013-11-13

    ... CLAUDIA FRIEDLANDER ROBERT MAX FRIESEN KATHLEEN ELLEN FUKUNAGA MIWA FULLER NICHOLAS ALAN FULLER NICHOLAS... SHIPLEY ROBERT ANTHONY SIM JEONG SUN SIMON ANTHONY NICHOLAS SIMON JULIE ANN SINN JUSTINE TUNG SITTARO... JAMES TAN YANQIANG TANAKA RYO TANG MARX THERN EDINA RITTER THERN JR ROBERT WILLIAM TIEN LAUREN TSAK YEN...

  20. Художники ходят по крышам домов / Ханно Соанс

    Index Scriptorium Estoniae

    Соанс, Ханно, 1974-

    2010-01-01

    Näitusest "Linna kohal" Tallinna Linnagaleriis. Teemaks on linnamajade katusepindade kasutuselevõtt. Kuraatorid Kadri Klementi ja Helis Heiter. Töödest näitusel. Osalevad: Anu Vahtra — Tallinna Kunstihoone, Claudia Doms ja Mikk Heinsoo — Saku Suurhall, Timo Toots — Lennujaam, Marit Ilison — Telliskivi Loomelinnak, Johnson & Johnson — Postimaja

  1. How Brazil joined the quest for a yellow fever vaccine

    OpenAIRE

    2013-01-01

    Brazil recently announced an agreement between its Bio-Manguinhos vaccine unit and two US companies to research and develop a new yellow fever vaccine. Claudia Jurberg and Julia D’Aloisio talk to Jaime Benchimol about the controversial history of the development of the vaccine that benefits millions of people today.

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Sebastian Fettig. Articles written in Journal of Biosciences. Volume 32 Issue 3 April 2007 pp 501-510 Articles. specific and unspecific responses of plants to cold and drought stress · Erwin H Beck Sebastian Fettig Claudia Knake Katja Hartig Tribikram Bhattarai · More Details Abstract ...

  3. Liderando proyectos

    OpenAIRE

    Piorun, Daniel; Giusti, Jose Luis

    2001-01-01

    Participantes del debate: Piñeiro, JoseFarfán, CarlosSantoalla, Juan CarlosColautti, RaúlCané, ClaudioLázaro, Claudia Fil: Piorun, Daniel. Universidad de Buenos Aires. Facultad de Ciencias Económicas Fil: Giusti, Jose Luis. Universidad de Buenos Aires. Facultad de Ciencias Económicas

  4. African Journal of Health Professions Education: Contact

    African Journals Online (AJOL)

    Principal Contact. Claudia Naidu Managing Editor Health and Medical Publishing Group Private Bag X1 Pinelands 7430 Cape Town South Africa Phone: + 27 (21) 532 1281. Email: claudian@hmpg.co.za. Support Contact. Getrude Fani Phone: +27 (21) 532 1281. Email: publishing@hmpg.co.za · AJOL African Journals ...

  5. Por lo menos quedó la historia

    Directory of Open Access Journals (Sweden)

    Jimena Montaña Cuéllar

    2007-10-01

    Full Text Available Historia del Hospital San Juan de Dios de Bogotá. María Claudia Romero lsaza, Mónica Zambrano Caicedo, Miguel Darío Cárdenas. Alcaldía Mayor de Bogotá, Instituto de Patrimonio Cultural, Universidad Nacional de Colombia, Bogotá, 2008, 149 págs.

  6. On Consumerism, Collective Action, and Whether Art Teaches Anything

    Science.gov (United States)

    Ruitenberg, Claudia W.

    2014-01-01

    In this review essay, Claudia Ruitenberg discusses Trevor Norris's "Consuming Schools," René Arcilla's "Mediumism," and Martha Nussbaum's "Not for Profit." While the primary focus of each book is different--with Norris concentrating on the pressures of consumerism and commercialism on K-12 schooling,…

  7. RESENHA - Para pensar sobre o Mundo del Trabajo y los Caminos de la Vida

    Directory of Open Access Journals (Sweden)

    Norberto Alayón

    2010-05-01

    Full Text Available

    El mundo del trabajo y los caminos de la vida.
    Trabajar para vivir; vivir para trabajar - Estela Grassi y Claudia
    Danani (organizadoras Espacio Editorial (Colección “Desarrollo
    Social y Sociedad”. Buenos Aires. 2009. 374 páginas.

  8. Beyond the Page: Students as Actor-Readers

    Science.gov (United States)

    Felske, Claudia Klein

    2005-01-01

    Claudia Klein Felske, a high school English teacher, has created a vital dramatic experience in the classroom with the help of a guest workshop leader. The three activities, such as how to read William Shakespeare, Metaphor Theater and character cacophony, which helped students to experience the intensity of language and discover ramifications of…

  9. The Political as Presence: On Agonism in Citizenship Education

    Science.gov (United States)

    Tryggvason, Ásgeir

    2017-01-01

    In recent years, an agonistic approach to citizenship education has been put forward as a way of educating democratic citizens. Claudia W. Ruitenberg (2009) has developed such an approach and takes her starting point in Chantal Mouffe's agonistic theory. Ruitenberg highlights how political emotions and political disputes can be seen as central for…

  10. Scham im Kino : Kleine Phänomenologie eines peinlichen Gefühls

    NARCIS (Netherlands)

    Hanich, Julian

    Wer ans Kino denkt, denkt nicht an Scham. Die Emotionsmaschine „Kino“ rührt das Publikum zu Tränen, versetzt es in Angst und Schrecken oder zwingt es zum Lachen. Zuschauer reagieren wütend, erfreut, angeekelt, sie staunen und bewundern. Vielleicht sind sie sogar heimlich in Cary Grant oder Claudia

  11. Traditsioonilise kujundkõne nüüdisaegsest uurimisest / Anneli Baran

    Index Scriptorium Estoniae

    Baran, Anneli, 1970-

    2015-01-01

    Tutvustus: Phraseologie und Parömiologie (sari ilmub aastast 1999; http://www.phraseologie.net ) ; Claudia Aurich. Proverb Structure in the History of English: Stability and Change. Schneider Verlag Hohengehren, 2012 ; Urška Valenčič Arh. "Ein Prinz auf der Erbse". Phraseologie und Übersetzung. Schneider Verlag GmbH, 2014

  12. Installation Service - Changes in opening hours

    CERN Multimedia

    GS Department

    2010-01-01

    For organizational matters, please note that, as from 15 March 2010, the Installation Service will have wen opening hours. The new schedule will be from 14:00 to 17:00 (Monday to Friday). Contact persons are: Martine Briant, Karine Robert and Claudia Bruggmann. The office address remains 73-3-014. Installation Service

  13. Gli archivi dell'Inquisizione in Italia: problemi storiografici e descrittivi. Roma, Archivio di Stato, 18 febbraio 2005

    Directory of Open Access Journals (Sweden)

    Andrea Del Col (editor

    2006-01-01

    Full Text Available It includes the folowing essays:Andrea Del Col, Presentazione Adriano Prosperi, Nuove prospettive per una storia dell'Inquisizione Grado Giovanni Merlo, Problemi documentari dell'Inquisizione medievale in Italia Silvana Seidel Menchi, I giudici dell'Inquisizione romana: inquisitori e vescovi, commissari, nunzi, cardinali, papi Andrea Del Col, I documenti del Sant'Ufficio come fonti per la storia istituzionale e la storia degli inquisiti Marco Pizzo, La Stanza Storica dell'Archivio del Sant'Uffizio: un metodo di intervento Francesca Cavazzana Romanelli, Il censimento della documentazione inquisitoriale riguardante l'Italia Giovanna Paolin - Andrea Del Col, La banca dati dei processi e la ricostruzione completa dell'attività del Sant'Ufficio di Aquileia e Concordia

  14. Invertebrate neuroscience and CephsInAction at the Mediterranean Society for Neuroscience Meeting Cagliari 2015.

    Science.gov (United States)

    Holden-Dye, Lindy; Fiorito, Graziano; Ponte, Giovanna

    2015-12-01

    Invertebrate neuroscience, and in particular cephalopod research, is well represented in the Mediterranean region. Therefore, the recent meeting of the Mediterranean Society for Neuroscience in Santa Margherita di Pula, Sardinia (12-15 June 2015) provided an excellent opportunity for invertebrate contributions. Furthermore, the Chair of an EU COST Action for cephalopod research (FA1301; www.cephsinaction.org ), Giovanna Ponte, together with Graziano Fiorito from the Stazione Zoologica, Naples, aligned a meeting of research groups working in the field of cephalopod neurophysiology from across Europe to coincide with the neuroscience meeting. This provided an exciting forum for exchange of ideas. Here we provide brief highlights of both events and an explanation of the activities of the COST Action for the broader invertebrate neuroscience community.

  15. Der Körper als Forschungsfeld The body as a field of research

    Directory of Open Access Journals (Sweden)

    Elke Brüns

    2004-03-01

    Full Text Available Der Körper bildete im letzten Jahrzehnt ein disziplinenübergreifend analysiertes Forschungsfeld. Mit ihrem Sammelband Körperbilder zwischen Natur und Kultur schließen Hildegard Macha und Claudia Fahrenwald an die interdisziplinäre Gender-Forschung an. Es ist das Ziel des Bandes, den umstrittenen „Grenzverlauf“ des Körpers „zwischen Natur und Kultur“ (S. 7 in den Blick zu nehmen. Die Beiträge stammen aus der Pädagogik, der Soziologie, der Theologie, der Altphilologie sowie aus der Geschichts- resp. Sportwissenschaft. Der Band ist in drei Abteilungen untergliedert, die systematische, historische und lebensweltlich orientierte Zugänge zum Thema bieten.In the last decade the body has been the subject of interdisciplinary research. The collected volume, Images of the Body between Nature and Culture, by Hildegard Macha and Claudia Fahrenwald contributes to interdisciplinary gender research. The volume aims to focus on the controversial positioning of the body ‘between nature and culture’ (p. 7. The articles come from pedagogy, sociology, theology, the classics, as well as from history and sports sciences. The volume comprises three parts, which provide systematic, historical and practical approaches to the topic.

  16. Berlinale Kuldkaru jagunes kahe filmi vahel / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2002-01-01

    Berliini 52. filmifestivali tulemustest. Festivali "Panorama Special" kavas olnud Peeter Simmi "Head käed" saavutas hea publikuedu ning jagas sloveenlase Maja Weiss'i filmiga "Piirivalvur" Manfred Salzgeberi auhinda, mis on mõeldud subtiitrite tegemiseks filmi levitamisel euroopa ekraanidele. Kuldkaru jagasid briti Paul Greengrassi "Verine pühapäev" ja jaapanlase Hayao Miyazaki animafilm "Vaimudest viidud". Elutöö-Kuldkarud said Claudia Cardinale ja Robert Altman

  17. Reducing Uncertainties in Future Climate Projections by Quantifying Human COntributions to 20th Century Climate Change

    Energy Technology Data Exchange (ETDEWEB)

    Gabriele Hegerl and IDAG members

    2011-07-31

    This report focuses on the period to 2010 including, after which the new round of the International Detection and Attribution group, led by Claudia Tebaldi, started. In 2011, some final work on report has been done, and outstanding tasks completed. However, most participants are now working on the new grant and hence the citations and work reported is focusing largely on the regular grant period.

  18. Circulatory Shock. Volume 34. Number 1. May 1991. International Conference on Shock (2nd), Meeting of European Shock Society (5th), Annual Meeting of the Shock Society (USA) (14th), Vienna Shock Form (3rd) Held in Vienna, Austria on 2-6 June 1991

    Science.gov (United States)

    1991-06-06

    OCTADECENOATE, AS A BURN TOXIN Takayuki Ozawa, Mika Hayakawa, Kazuhiro Kosaka, Satoru Sugiyama, Kazuhisa Yokoo, Hisashi Aoyama, and Yohei Izawa Department...shock. 41 CARDIOPULMONARY HEMODYNAMIC AND PERIPHERAL CIRCULATORY RESPONSES IN SHOCK T. Muteki, N. Kaku. T. Fukushige, I. Kohno and T. Hiraki Department...Tadashi, 242 Machleidt, Werner, 213 Ozawa, Takayuki , 11 Kawarada, Yoshifumi, 442 Mackie, D.P., 348 Ozawa, Kazue, 268 Keser, Claudia, 380 Maitra, Subir R

  19. Characterizing Treatable Causes of Small Fiber Polyneuropathy in Gulf War Veterans

    Science.gov (United States)

    2015-10-01

    Professor Osvaldo Nascimento, MD (Universidade Federal Fluminense, Copacabana, Rio de Janeiro , Brazil) Professor Claudia Sommer, MD (University of...that serves as the entry point to a secure platform where the global panel of Experts can upload actual de -identified case reports to be used for the...Netherlands) Professor Alejandra Gonzáles-Duarte, MD (Instituto Nacional de Ciencias Médicas y Nutrició Salvador Zubiran, Tlalpa, Mexico

  20. Revivamos nuestra historia

    Directory of Open Access Journals (Sweden)

    Myriam Bautista

    2015-12-01

    Full Text Available El paraíso del diablo. Roger Casement y el informe del Putumayo, un siglo después. Claudia Steiner Sampedro, Carlos Páramo Bonilla, Roberto Pineda Camacho (Compiladores. Universidad de los Andes, Facultad de Ciencias Sociales, Departamento de Antropología; Universidad Nacional de Colombia, Facultad de Ciencias Humanas, Departamento de Antropología, Bogotá, 2014, 462 págs., il.

  1. Fabrication and Characterization of Surrogate Glasses Aimed to Validate Nuclear Forensic Techniques

    Science.gov (United States)

    2017-12-01

    the glass formed during a nuclear event, trinitite [14]. The SiO2 composition is generally greater than 50% for trinitite and can vary appreciably...CHARACTERIZATION OF SURROGATE GLASSES AIMED TO VALIDATE NUCLEAR FORENSIC TECHNIQUES by Ken G. Foos December 2017 Thesis Advisor: Claudia...December 2017 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE FABRICATION AND CHARACTERIZATION OF SURROGATE GLASSES AIMED TO

  2. Los trabajos domésticos y la proveeduría: entre permanencias, conflictos y cambios

    OpenAIRE

    Puyana Villamizar, Yolanda; Mosquera Rosero, Claudia

    2002-01-01

    El texto de Yolanda Puyana y Claudia Mosquera hace parte de una amplia investigación sobre cambios en las representaciones sociales de la maternidad y la paternidad; devela mayores permanencias que cambios alrededor de los repartos entre hombres y mujeres en las prácticas relacionadas con el trabajo doméstico y la proveeduría, aún en estos comienzos del Siglo XXI.

  3. Cyber Therapy II, Virtual Healing, Designing Reality

    Science.gov (United States)

    2006-08-01

    exposures. The initial, prototype model goal was to see if the subjects were able to use the addresses smallpox and uses chicken pox and system, and to...Barcelona, Spain training for schizophrenia as well as cognitive Autonomous University of State of Mexico therapy for autism. This study developed a system...Toluca, Mexico for measuring schizophrenia patients’ behavioral E-mail: claudia.liliana.hardy@estudiant.upc.edu characteristics in a Virtual

  4. Debates en torno de la anticoncepción de emergencia en Chile

    OpenAIRE

    Brown, Josefina Leonor

    2007-01-01

    El artículo trata del libro Voces en Emergencia: el discurso conservador y la píldora del día después, escrito por la investigadora de FLACSO, Claudia Dides, da cuenta del recorrido de los debates en la prensa escrita de su país, Chile, en relación con la política de anticoncepción de emergencia allí implementada.

  5. Interdisciplinarity between graphic design and communication

    OpenAIRE

    Sagin, Lis Antunes; Faculdade Pitágoras; Gomes, Rogério Zanetti; Coordenador da Pós graduação em Design e Cognição e Mídia da Faculdade Pitágoras. Unidade Londrina.

    2011-01-01

    In this paper we explore interdisciplinarity as an instrument of union, between the two disciplines of communication, graphic design and communication, practice of the profession. The research was conducted by reviewing literature; It is exposing a case related to magazine "CLAUDIA" pointing out how this unification has brought success to the complexity and design in a subtle and complete. Neste trabalho explora-se a interdisciplinaridade como um instrumento de união entre duas disciplinas...

  6. Journal of Mormon History Vol. 38, No. 3, Summer 2012

    OpenAIRE

    2012-01-01

    CONTENTS LETTER --Fitz John Porter’s Letter William P. MacKinnon, vii ARTICLES --Mormonism in Cultural Context: Guest Editors’ Introduction J. Spencer Fluhman, Steven C. Harper, and Jed Woodworth, 1 --A Charmed Life Claudia L. Bushman, 5 --The Hermeneutics of Generosity: A Critical Approach to the Scholarship of Richard Bushman Stuart Parker, 12 --To Mend a Fractured Reality: Joseph Smith’s Project Philip L. Barlow, 28 --The Language of Heaven: Prolegomenon to the Stud...

  7. Preferences of patients undergoing hemodialysis – results from a questionnaire-based study with 4,518 patients

    OpenAIRE

    Janssen, Inger M.; Gerhardus,Ansgar; von Gersdorff,Gero; Schaller,Mathias; Barth,Claudia; Scheibler,Fueloep; Baldamus,Conrad

    2015-01-01

    Inger Miriam Janssen,1 Ansgar Gerhardus,2,3 Gero D von Gersdorff,4 Conrad August Baldamus,4 Mathias Schaller,4 Claudia Barth,5 Fueloep Scheibler6 1Department of Epidemiology and International Public Health, Bielefeld University, Bielefeld, Germany; 2Department for Health Services Research, University of Bremen, Bremen, Germany; 3Health Sciences Bremen, University of Bremen, Bremen, Germany; 4Department of Internal Medicine II, University Hospital of Cologne, Cologne, Germany; 5KfH K...

  8. El impacto de las redes sociales virtuales en la identidad y subjetividad de los adolescentes /

    OpenAIRE

    Correa González, Eleazar

    2011-01-01

     tesis que para obtener el grado de Doctor en Pedagogía, presenta Eleazar Correa González ; asesor Concepción Barrón Tirado, Guillermo González Rivera, Marco Antonio Jiménez García, Patricia Mar Velasco, Claudia Pontón Ramos. vii, 355 páginas : ilustraciones, diagramas, fotografías. Doctorado en Pedagogía UNAM, Facultad de Filosofía y Letras, 2011

  9. Lift the quilt in case of atrial fibrillation and disc prolapse

    OpenAIRE

    Bastovansky, Adam; Ziegler, Kathrin; Stöllberger, Claudia; Finsterer, Josef

    2012-01-01

    Adam Bastovansky,1 Kathrin Ziegler,2 Claudia Stöllberger,2 Josef Finsterer31Department of Radiology, 2Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria; 3Danube University Krems, Krems, AustriaBackground: Peripheral embolism to the lower extremities may mimic disc prolapse with severe consequences.Case report:  A 71-year-old male with a history of chronic alcoholism developed low back pain radiating to both lower extremities in a nonradicular distribution an...

  10. Laser shock peening on a 6056-T4 aluminium alloy for airframe applications

    CSIR Research Space (South Africa)

    Glaser, D

    2014-03-01

    Full Text Available stream_source_info Pityana1_2014_ABSTRACT ONLY.pdf.txt stream_content_type text/plain stream_size 1356 Content-Encoding ISO-8859-1 stream_name Pityana1_2014_ABSTRACT ONLY.pdf.txt Content-Type text/plain; charset=ISO-8859-1... Laser Shock Peening on a 6056-T4 Aluminium Alloy for Airframe Applications Daniel Glaser, Claudia Polese, Rachana D. Bedekar, Jasper Plaisier,Sisa Pityana, Bathusile Masina, Tebogo Mathebula, and Enrico Troiani Keywords: Laser Shock Peening...

  11. Social Media Principles Applied to Critical Infrastructure Information Sharing

    Science.gov (United States)

    2013-12-01

    Stats, “Popular Apps and Tweets,” (n.d.), http://tweetstats.com/twitter_stats; Facebook Newsroom, “Key Facts”; Delicious, “About Us,” (n.d.), https...institutions. Web 1.0, by contrast, refers to an era of 82 Facebook Newsroom, “Key Facts.” 83 Twitter Stats, “Popular Apps and Tweets.” 84 Wikipedia...The launching success of Claudia Costin’s revitalization of Rio de Janeiro’s education system was directly engaging the teachers in the improvement

  12. Goldin and Katz and Education Policy Failings in Historical Perspective

    OpenAIRE

    Arnold Kling; John Merrifield

    2009-01-01

    In The Race Between Education and Technology, Claudia Goldin and Lawrence Katz employ a powerful theoretical framework to investigate how inequality is affected by the interrelation between changes in technology and changes in job-market skills. The investigation is carried out with great vision and a combination of scholarly methods. In this review essay, we embrace the theoretical core of the book, but find a number of problems in the execution. We see a need to distinguish between attendin...

  13. Rational and Emotional Communication in Advertising in Women's Magazines in Brazil

    OpenAIRE

    Edward Robinson Marin; Nadia Kassouf Pizzinatto; Antonio Carlos Giuliani

    2014-01-01

    This article investigated the incidence of rational and emotional arguments in messages from 5.536 advertisements of six women's magazines in Brazil (Claudia, Nova, Estilo, Marie Claire, Elle and Gloss), published between May / 2008 and August / 2009. The methodology was based on an exploratory study, supported on a scale of 14 items, by Resnik and Stern (1977), which recommend matching appeals to attitude toward the product, that is, use informative advertising, based on rational appeals for...

  14. Entre dos exilios: Cesare Civita, un editor italiano en Buenos Aires, desde la guerra mundial hasta la dictadura militar (1941- 1976

    Directory of Open Access Journals (Sweden)

    Scarzanella, Eugenia

    2009-04-01

    Full Text Available This paper deals with the history of an Argentinian publishing house called Editorial Abril, which was founded in 1941 by Cesare Civita, a Jewish immigrant who left Italy after the «race laws» approval. Abril published cartoons (Donald Duck, photo novels (Idilio, women’s magazines (Claudia and news magazines (Panorama. Abril was a family business which knew how to use a wide relation network in Argentina, Italy and the United States. The history of this publishing house ends with Cesare Civita’s new exile in 1976. The material used includes file sources, testimonies, journals and books.

    El artículo trata de la historia de una editorial argentina, la Editorial Abril creada en 1941 por Cesare Civita, un inmigrante judío que abandonó Italia después de la aprobación de las «leyes raciales». Abril publicaba historietas (El Pato Donald, fotonovelas (Idilio, revistas Femeninas (Claudia y de actualidad (Panorama. Abril era una empresa familiar que supo utilizar una vasta red de relaciones en la Argentina, Italia y los Estados Unidos. La historia de la Editorial termina con un nuevo exilio de Cesare Civita en 1976. Se utilizan: fuentes de archivo, testimonios, revistas y libros.

  15. Elusive Justice, Changing Memories and the Recent Past of Dictatorship and Violence in Uruguay: An Analysis of the 2012 Public Act in the Gelman Case

    Directory of Open Access Journals (Sweden)

    Francesca Lessa

    2014-09-01

    Full Text Available This article examines the Public Act of Acknowledgment of International Responsibility and Recovery of the Memory of María Claudia García de Gelman held in the Uruguayan parliament on 21 March 2012 through a theoretical framework of memory narratives. The Inter-American Court of Human Rights ordered Uruguay to hold the Public Act as part of its February 2011 ruling in the Gelman v. Uruguaycase, which condemned its failure to investigate and prosecute individuals responsible for disappearing María Claudia García de Gelman and illegally adopting her baby daughter Macarena, while denying her knowledge of her true identity for over two decades. The Public Act was a memorialising event intended as an act of reparation, which also triggered irruptions of memory in Uruguay, resurfacing memory debates and discussions about the recent past of dictatorship and violence. The Public Act exposed once again the continued antagonisms between memory narratives of violence and justice that have existed in the Uruguayan political and social landscape since 1985. While the Act was an expression of the “state terrorism” narrative, its unfolding resulted in the resurfacing of narratives of “war” and “two demons” in the social and political arenas and of new interpretations of these narratives in light of events and politics in 2012.

  16. Os Meios de Comunicação e a Figura da Mulher: uma reflexão sobre a personagem Clara da telenovela Em Família

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Baccega

    2016-06-01

    Full Text Available O presente artigo tem por objetivo refletir acerca da construção da figura da mulher operada pelos meios de comunicação, através de um dos seus produtos culturais, a telenovela brasileira. Para tanto, propõe uma investigação que aborda a visibilidade da mulher na mídia, trazendo como arcabouço teórico Baccega (1994; 1999, Escosteguy (2011 e Hall (2013, no que tange aos discursos midiáticos; Lippmann (1966, Bourdieu (2002, Scott (1995, Butler (2015 e Louro (2000 para refletir sobre a figura da mulher. Levando em conta o contexto hegemônico, o presente artigo propõe discutir a ideologia bem como a indústria cultural a fim de analisar, como objeto empírico, a personagem Clara, protagonizada pela atriz Giovanna Antonelli, na telenovela brasileira Em Família, da TV Globo.

  17. Book review: Euro-Latin American cooperation and relations and South-South cooperation

    Directory of Open Access Journals (Sweden)

    Jairo Agudelo Taborda

    2014-09-01

    Full Text Available Reviewed books: Tassara, Carlo Cooperación para el desarrollo, relaciones internacionales y políticas públicas: Teorías y prácticas del diálogo euro-latinoamericano. Ediciones UNAULA, 2013. 302 págs. Marín Aranguren, Erli Margarita y Ro­mero Amaya, María Claudia (eds. Cuando el Sur piensa el Sur: Los giros de la cooperación al desarrollo. Univ. Externado de Colombia, 2013. 362 págs.

  18. Políticas e poéticas feministas : imagens em movimento sob a ótica de mulheres latino-americanas

    OpenAIRE

    Maria Célia Orlato Selem

    2013-01-01

    Resumo: A presente pesquisa busca identificar poéticas feministas no cinema de mulheres latino-americanas neste século XXI. Nesse intuito, foram selecionados os seguintes filmes: La teta asustada, de Claudia Llosa (Peru - 2009); Que tan lejos, de Tania Hermida (Equador - 2006); Rompecabezas, Natalia Smirnoff (Argentina, 2009); Entre nós, de Paola Mendoza e Gloria La Morte (Colômbia, 2009); Sonhos Roubados, de Sandra Werneck (Brasil, 2009); En la puta vida, de Beatriz Flores Silva (Uruguai, 20...

  19. Erfolgreiche Ambivalenz. Sarah Bernhardts Inszenierungen von Weiblichkeit Successful Ambivalence: Sarah Bernhardt’s Staging of Femininity

    Directory of Open Access Journals (Sweden)

    Doris Kolesch

    2007-03-01

    Full Text Available Claudia Thorun untersucht die Inszenierungen von Weiblichkeit am Beispiel der Schauspielerin Sarah Bernhardt, die im späten 19. und beginnenden 20. Jahrhundert zu den erfolgreichsten Künstlerinnen ihrer Zeit gehörte. Dazu werden die Darstellungen ausgewählter Rollenfiguren ebenso analysiert wie die schauspieltheoretischen Überlegungen Bernhardts und schließlich die Rezeption ihres Schaffens in Theaterkritiken, aber auch Werbebildern und Medieninszenierungen. Das lesenswerte Buch erlaubt Einblicke in konkrete theatrale Verkörperungen von Weiblichkeit im Fin de Siècle, unternimmt jedoch keine ausreichende theatergeschichtliche wie kulturwissenschaftliche Kontextualisierung, obwohl die Verfasserin in der Einleitung ihrer Studie das Ziel formuliert, Gendertheorie, Theatergeschichte und Kulturwissenschaft zu verknüpfen.Claudia Thorun examines the staging of femininity using the example of the actress Sarah Bernhardt, who in the late nineteenth century was among the most successful artists of her time. The study includes analyses of the representation of specific roles, Bernhardt’s theories on acting, and finally the reception of her work in theater critiques, as well as advertisement images and representations in the media. The book, which is a worthwhile read, allows for insight into the concrete theatrical embodiment of femininity at the fin de siècle. It does not provide, however, adequate contextualization within theater history nor cultural studies, even though in her introduction, the author asserts that it is her intention to link together gender theory, theater history, and cultural studies.

  20. An approach to "The Milk of Sorrow" as a hispanic intercultural narrative film

    OpenAIRE

    Italo Oscar Riccardi León

    2015-01-01

    The following article aims to develop a Hispanic intercultural cinematic study of the film “The Milk of Sorrow,” written and directed by the Peruvian filmmaker Claudia Llosa that was awarded the Golden Bear at the Berlin Film Festival in 2009. The plot of the movie tells the story of Fausta, a young girl descendant of Amerindians who suffers from a rare disease called “milk of sorrow” or “shock syndrome”, the name given to a supposed disease transmitted by fear and suffering of the mother for...

  1. Experimental Design for CMIP6: Aerosol, Land Use, and Future Scenarios Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Arnott, James [AGCI

    2015-10-30

    The Aspen Global Change Institute hosted a technical science workshop entitled, “Experimental design for CMIP6: Aerosol, Land Use, and Future Scenarios,” on August 3-8, 2014 in Aspen, CO. Claudia Tebaldi (NCAR) and Brian O’Neill (NCAR) served as co-chairs for the workshop. The Organizing committee also included Dave Lawrence (NCAR), Jean-Francois Lamarque (NCAR), George Hurtt (University of Maryland), & Detlef van Vuuren (PBL Netherlands Environmental Change). The meeting included the participation of 22 scientists representing many of the major climate modeling centers for a total of 110 participant days.

  2. Targeting BRAF V600E and Autophagy in Pediatric Brain Tumors

    Science.gov (United States)

    2015-10-01

    tumors in vivo by using combination therapy with chloroquine (autophagy inhibition) and vemurafenib (Raf-inhibitor). The major goals of the project as...BRAFV600E Cell lines used : BRafCA/WTInk4alox/lox mouse neurospheres (Cell line provided by Dr. Claudia Petritsch, UCSF). We have been able to successfully...a dose dependent manner to chloroquine as shown by MTS and LDH. 0 1.25 2.5 5 10 20 40 0 50 100 150 CQ (µM) % S ur vi va l 0 1 2 3 LD H release

  3. Social media fundamentals, models, and ranking of user-generated content

    CERN Document Server

    Wyrwoll, Claudia

    2014-01-01

    The increasing amount of user-generated content available on social media platforms requires new methods to find, evaluate, and to compare. To this day, existing ranking approaches to user-generated content do not allow for evaluation across platforms by exploiting its metadata. User-generated content, such as blog postings, forum discussions, shared videos etc. does however contain information that can be used for its evaluation independent of specific search interests. Claudia Wyrwoll presents a query- and language-independent ranking approach that allows for global evaluation of user-genera

  4. Humanity in God's Image: An Interdisciplinary Exploration

    DEFF Research Database (Denmark)

    Welz, Claudia

    . Claudia Welz offers an interdisciplinary exploration of theological and ethical 'visions' of the invisible. By analysing poetry and art, Welz exemplifies human self-understanding in the interface between the visual and the linguistic. The content of the imago Dei cannot be defined apart from the image......How can we, in our times, understand the biblical concept that human beings have been created in the image of an invisible God? This is a perennial but increasingly pressing question that lies at the heart of theological anthropology. Humanity in God's Image: An Interdisciplinary Exploration...

  5. Leadership in a Gender Diverse Military: Women at the Nation’s Service Academies - The Twenty Year Mark

    Science.gov (United States)

    1997-03-23

    54% 37% INTJ 11.3 7.9 INFJ 9.7 5.3 INTP 9.7 7.9 INFP 8.1 5.3 ENTJ 9.7 13.2 ENFJ 6.5 5.3 ENTP 4.8 7.9 ENFP 9.7 5.3...been forgotten. On a less theoretical level, Major General Claudia J. Kennedy discussed professional interpersonal relationships . First she focused...cross-gender mentoring relationship . In these experiences, 30% of the men and 2% of the women were the mentors, 51% of women and 32% of men were the

  6. VI Actas Congreso. Miedos, culpas, violencias invisibles y su impacto en la vida de las mujeres: ¡A vueltas con el amor!

    OpenAIRE

    Gil Gómez, Alicia; Escrig Gil, Gemma; Forcada Martínez, Águeda

    2010-01-01

    ÍNDICE. Presentación,ESPERANZA BOSCH FIOL. Introducción poética, PACA GABALDÓN, CLAUDIA GRAVI Y Mª LUISA SAN JOSÉ. Justo el amor, MARÍA XOSÉ AGRA ROMERO. I. CONFERENCIAS El género en cuestión. Modelos imposibles y modelos perversos,DOLORES JULIANO CORREGIDO. La propia identidad y las relaciones de amor en la adolescencia, AURORA LEAL GARCÍA Feelings of fear and guilt among women in conflicts and wars.Miedos y culpas de mujeres en situaciones de conflictos y de guerra, RAN...

  7. Andrea Fleschenberg, Claudia Derichs: Handbuch Spitzenpolitikerinnen. Wiesbaden: VS Verlag für Sozialwissenschaften 2008

    Directory of Open Access Journals (Sweden)

    Christiane Lemke

    2009-07-01

    Full Text Available „Frauen an die Macht“ – diese schon vor Jahrzehnten erhobene Forderung ist heute immer noch aktuell. Die politische Partizipation von Frauen hat sich zwar deutlich verbessert, aber in Führungspositionen sind sie immer noch selten anzutreffen. Das anschauliche Handbuch führt für alle Erdteile detailliert aus, unter welchen sozioökonomischen, institutionellen und kulturellen Einflussfaktoren Frauen zu Staats- und/oder Regierungschefinnen werden. Zahlreiche Einzelbiographien beleuchten die persönlichen Hintergründe.“Women in positions of power” – This centuries-old demand is still pertinent today. Women’s participation in politics has admittedly gotten much better, but they are still rarely seen in positions of leadership. The descriptive handbook provides details for each continent, illustrating under which socioeconomic, institutional, and cultural influential factors women become heads of state or government. Numerous individual biographies illuminate the personal histories.

  8. Publicidade e ética: um estudo da construção da imagem da mulher

    Directory of Open Access Journals (Sweden)

    Elizabeth Moraes Gonçalves

    2010-02-01

    Full Text Available O texto propõe uma reflexão sobre a ética da responsabilidade na publicidade veiculada nas revistas Claudia e Nova. Trata-se de uma pesquisa descritiva, resultante da leitura dos anúncios selecionados, subsidiada por teóricos da Análise do Discurso da linha francesa, que busca averiguar como a mulher é representada. Constatou-se que no contexto da sociedade contemporânea o retrato da mulher como sedutora ainda está presente, mesmo que em vários momentos ela apareça como protagonista de sua própria vida.

  9. Um fim à negligência em relação aos problemas da mulher negra!

    Directory of Open Access Journals (Sweden)

    Claudia Jones

    2017-10-01

    Full Text Available O artigo é a tradução de um ensaio publicado originalmente em 1949, pela intelectual e ativista negra Claudia Jones na revista Political Affairs. No ensaio, Jones demonstra as origens e as múltipmas dimensões da dinâmica do sistema de opressão a que eram submetidas mulheres negras e critica a inabilidade dos comunistas estadunidenses em mobilizá-las. Ao argumentar que as mulheres negras compunham a fração superexplorada da classe trabalhadora, a autora as posiciona como parecela central da militância internacional contra o fascismo e o imperialismo.

  10. Ciné Club

    CERN Multimedia

    Ciné Club

    2010-01-01

    Thursday 23 September 2010 at 20:30 CERN Main Auditorium Lock, Stock and Two Smoking Barrels By: Guy Ritchie (UK, 1998) 107 min With/avec: Jason Flemyng, Dexter Fletcher, Nick Moran, Jason Statham   Four London working class stiffs pool their money to put one in a high stakes card game, but things go wrong and they end up owing half a million pounds and having one week to come up with the cash. Overhearing their neighbours in the next flat plotting to hold up a group of out-of-their-depth drug growers, our heros decide to stitch up the robbers in turn. In a way the confusion really starts when a pair of antique double-barrelled shotguns go missing in a completely different scam.   Original version english with english subtitles Entrance : 2 CHF Projection from DVD http://cineclub.web.cern.ch/Cineclub/   Thursday 30 September 2010 at 20:30 CERN Main Auditorium Facing Windows / La finestra di fronte By/de : Ferzan Ozpetek (Italy, 2003) 106 min With/avec: Giovanna Mezz...

  11. Reseñas. Books Review

    Directory of Open Access Journals (Sweden)

    Díaz, Liliana

    2014-10-01

    Full Text Available TORRE, Claudia, El otro desierto de la nación argentina. Antología de narrativa expedicionaria, Bernal, Argentina, Editorial Universidad de Quilmes, 2011, 387 pp. MAURO, Diego y LICHTMAJER, Leandro (compiladores, Los costos de la política. Del Centenario al primer peronismo, Imago Mundi, Buenos Aires, 2014, 130 pp. DE MARCO; Miguel Ángel (h. Ciudad Puerto, Universidad y Desarrollo Regional, Rosario, 1919-1968. CEHDRE, Rosario, 2013, 542 pp. GUARDIA, Sara Beatriz. Primer Congreso Internacional. Las mujeres en los procesos de Independencia de América Latina. Lima, Perú. Sara Beatriz Guardia Edición, CEMHAL, UNESCO, USMP, 2014. 495 pp

  12. [Eesti Kunstiakadeemia uue hoone rahvusvaheline arhitektuurivõistlus] : EKA maja

    Index Scriptorium Estoniae

    2008-01-01

    Žürii hääletustulemused ja hinnangud. I preemia - "Art Plaza", taani arhitektid Uffe Leth Laursen, Tue Hesselberg Foged, Karsten Gori, Sinus Lynge, Greta Tedje, Simon Sorensen, Lawrence Aeberhard, Lyndal Brown, Morgan Jacobsen (AB Sea + Effekt). II - "TLN 247", Hollandi AB NAT Architecten bv, M. van Zijl, V. van der Klei, F. A. van Manen, B. de Graaf, T. M. van Dijkhuizen, S. van der Meer, D. Awe, N. Limburg, J. Kuilman. III - "Arts Factory", Portugali AB Neralp-Arquitectura Engenharia e Construcoes Lda, Paulo Sergio Goncalves Teixeira de Sousa. Ergutuspreemia - "Publicsection", Hollandi AB BOARD, Bernd Upmeyer, kaastöö: Claudia Hess ja "Sashimi", jaapani arhitekt Francois Blanciak

  13. Geschlechtertektonik – Hollywoodkino um 2000 Gender Tectonics in Contemporary Hollywood

    Directory of Open Access Journals (Sweden)

    Sylvia Mieszkowski

    2003-11-01

    Full Text Available Auch im zeitgenössischen Hollywood-Film sind narrative Muster und visuelle Repräsentationen maßgeblich entlang der ‚gender‘-Achse organisiert. In sechs Lektüren untersucht Claudia Liebrand konzeptuelle Verschiebungen und Verwerfungen, die entstehen, wenn sich die Spannung der Geschlechterdifferenz unter dem Druck konfligierender Differenzkonstrukte entlädt.Contemporary Hollywood Cinema organises its narrative patterns and visual representations along an axis that is determined by gender. Liebrand’s readings of six films investigate conceptual displacements and faults which arise when tensions built up by gender difference discharge, sometimes with unexpected results, under the extra pressure of conflicting constructs such as race or sexuality.

  14. Il loricato acefalo di Rusellae (Roselle, GR: una proposta di identificazione

    Directory of Open Access Journals (Sweden)

    Eleonora Romanò

    2013-07-01

    Full Text Available Lo studio è incentrato sul tentativo di comprendere la scena presente sulla lorica di una statua acefala di probabile fine età claudia rinvenuta nell'area archeologica di Rusellae (Roselle, GR all'interno di un edificio connesso al culto imperiale. La decorazione analizzata è composta da diversi elementi: un trofeo di armi ed un'aquila in posizione pressocchè centrale, ai loro lati si dispongono figure umane interpretabili come barbari e per le quali si propone l'identificazione con il britanno Caratacus accompagnato dai suoi familiari mentre rivolge una supplica di liberazione al Senato ed all'imperatore Claudio, secondo l'episodio riportato negli Annales di Tacito (12.33-40.

  15. Progress in biogas II - Biogas production from agricultural biomass and organic residues. Pt. 2. Proceedings; Progress in Biogas II - Biogasproduktion aus landwirtschaftlicher Biomasse und organischen Reststoffen. T. 2. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-08-12

    Within the International Congress at the University of Hohenheim (Stuttgart, Federal Republic of Germany) from 29th March to 1st April, 2011, beside numerous poster presentations the following lectures were held: (1) Coverage of digestate storage tanks: why it is necessary and technical solutions (Paolo Balsari); (2) Digestate Standard in the United Kingdom (David Collins); (3) Unraveling the causes of nitrogen losses from the bioslurry and strategies for value addition (Steven Nyanzi); (4) Biological nitrogen removal from the liquid phase of anaerobic digestate of livestock effluents and energy crops (Francesco Fatone); (5) Ammonium loss of digestate during drying (Claudia Maurer); (6) Innovative process of gaining efficient fertilizers from digestates (Daniel Schloz).

  16. El Parque Nacional del Café

    Directory of Open Access Journals (Sweden)

    Ernesto Barrera Duque

    2013-03-01

    Full Text Available Claudia Guevara, gerente de mercadeo, enfrenta la meta de 520.000 visitas para el año 2006, y por este motivo debe presentar un plan comercial para lograr este objetivo. Se presenta información relevante sobre la historia del Parque Nacional del Café (PNC, el producto, mercado, precios, canales y acciones de comercialización, comunicación comercial que permitirá discutir qué estrategias y tácticas emprender para la temporada de diciembre y para el siguiente año de operaciones. Entre los objetivos a lograr está potenciar la diferenciación, aumentar la base de visitantes y atraer turistas extranjeros.

  17. Investigating the domestication of convergent mobile media and mobile internet by children and teens: preliminary issues and empirical findings on opportunities and risks

    Directory of Open Access Journals (Sweden)

    Barbara Scifo

    2013-02-01

    Full Text Available The paper, starting with some preliminary considerations about the new mobile media ecology, in which today's children live, and with some data about the diffusion of mobile internet and smartphones among children, aims to focus on three main points. I first ponder the new opportunities and new risks arising for children from the diffusion of such technologies, and the related usage practices, looking at some preliminary empirical findings, coming from qualitative researches I conducted with some of my colleagues from OssCom (Giovanna Mascheroni and Maria Francesca Murru, about the domestication of smartphones, mobile social networking and location-based practices in the Italian youth context. Then, I explore the new challenges in parental mediation, starting from qualitative evidence gathered from Italian parents. I finish illustrating the contribution of the new European project Net Children Go Mobile towards filling the current knowledge gap regarding European children’s mobile internet and convergent mobile media use, risks and online safety. Investigación de la domesticación de la convergencia de los medios móviles e internet móvil por parte de niños y adolescentes: cuestiones previas y hallazgos empíricos sobre las oportunidades y riesgos Resumen A partir de algunas consideraciones preliminares sobre la nueva ecología de los medios móviles, en los que los niños de hoy viven, y con algunos datos sobre la difusión de Internet móvil y los teléfonos inteligentes, este documento tiene como objetivo centrarse en tres puntos principales. El primero, reflexionar sobre las nuevas oportunidades y nuevos riesgos para los niños con este tipo de tecnologías, y las prácticas de uso relacionados, mirando a algunos hallazgos empíricos preliminares, procedentes de investigaciones cualitativas que llevé a cabo con algunos de mis colegas de OssCom (Giovanna Mascheroni y Maria Francesca Murru, acerca de la domesticación de los tel

  18. Hollywood’s Terror Industry: Idealized beauty and The Bluest Eye

    Directory of Open Access Journals (Sweden)

    E C Koch

    2014-07-01

    Full Text Available Toni Morrison’s novel The Bluest Eye (1970 examines the effects of 1940s American white cultural hegemony on her black characters: Claudia, Pauline, and Pecola. The dominant influence of white society, specifically white ideals of beauty, are perpetuated through film, and exemplified by such actresses as Shirley Temple and Greta Garbo. The terrifying nature of the Hollywood ideal is borne from its influence and ubiquity, and is highlighted by Pecola’s deranged pursuit of this impossible standard of beauty. Ultimately by attempting to realize this paradigm, blacks are disenfranchised while the ideal is recharged with the power of those who continue to pursue it. Keywords:The Bluest Eye, Racial Hegemony, Film Studies, Terror, Ideals of Beauty.

  19. Algunas particularidades socioculturales y lingüísticas del proceso de enseñanza – aprendizaje de ELE a inmigrantes rusohablantes en España

    Directory of Open Access Journals (Sweden)

    Kunetsov, Georgy

    2010-09-01

    Full Text Available El presente artículo basado en la memoria final del Máster en Enseñanza de Español como Lengua Extranjera (UIMP, 2007-2008, tutora Claudia Fernández Silva trata algunos aspectos socioculturales y lingüísticos del alumnado inmigrante procedente de los países de la extinta URSS y las particularidades del proceso enseñanza – aprendizaje que influyen en el trabajo de un profesor de ELE en España. Se da un breve análisis de las principales dificultades morfológicas, sintácticas y otras, al igual que del bagaje sociocultural y emocional del inmigrante rusohablante y el papel del profesor en el proceso de integración.

  20. Clause complexes as the basis for construing the narrative point of view in translation context

    Directory of Open Access Journals (Sweden)

    Adail Sebastião RODRIGUES-JÚNIOR

    Full Text Available ABSTRACT This article briefly discusses the role of expansions for construing the characters’ identities and personality traits in Oscar Wilde’s novel The Picture of Dorian Gray and its translation, made by João do Rio, and adaptations, made by Clarice Lispector and Claudia Lopes, into Brazilian Portuguese. The discursive configuration or narrative axis that unveils the narrative point of view is the central linguistic realization of the discussion. The paper also problematizes the concept of omission and rewriting in the literary translation context, asserting that these kinds of (retextualizations may create negative cultural impacts on the target-text reader. The discussion is informed by the principles of systemic-functional grammar and its contributions to literary translation, especially the concepts of projection and clause complex.

  1. The MAS Six Years in Power in Bolivia

    Directory of Open Access Journals (Sweden)

    Ton Salman

    2012-04-01

    Full Text Available Review Essay of:– The Rise of Evo Morales and the MAS, by Sven Harten. London/New York: Zed Books, 2011.– Evo Morales and the Movimiento al Socialismo in Bolivia; The First Term in Context, edited by Adrian J. Pearce. London, Institute for the Study of the Americas, 2011.– El estado de derecho como tiranía, by Luis Tapia. La Paz: CIDES/UMSA, 2011.– From Rebellion to Reform in Bolivia: Class Struggle, Indigenous Liberation and the Politics of Evo Morales, by Jeffery R. Webber. Chicago: Haymarket Books, 2011.– La democracia desde los márgenes: Transformaciones en el campo político boliviano, by María Teresa Zegada, with Claudia Arce, Gabriela Canedo and Alber Quispe. La Paz: Muela del Diablo Editores/CLACSO, 2011.

  2. War rape, natality and genocide.

    Science.gov (United States)

    Schott, Robin May

    2011-01-01

    Feminist philosophy can make an important contribution to the field of genocide studies, and issues relating to gender and war are gaining new attention. In this article I trace legal and philosophical analyses of sexual violence against women in war. I analyze the strengths and limitations of the concept of social death—introduced into this field by Claudia Card—for understanding the genocidal features of war rape, and draw on the work of Hannah Arendt to understand the central harm of genocide as an assault on natality. The threat to natality posed by the harms of rape, forced pregnancy and forced maternity lie in the potential expulsion from the public world of certain groups—including women who are victims, members of the 'enemy' group, and children born of forced birth.

  3. The coordination office at SIREME 2008 exhibition

    International Nuclear Information System (INIS)

    Grotz, Claudia; Cassin, Fabrice; Evrard, Aurelien; Froeding, Veronique; Galaup, Serge; Kaelble, Laure; Persem, Melanie; Regnier, Yannick; )

    2008-01-01

    The French-German office for Renewable energies (OFAEnR) organised several presentations at the occasion of the SIREME International exhibition of renewable energies and energy management. This document brings together these presentations (slides) dealing with: 1 - The new German Renewable Energy Sources Act (EEG) and its impact on wind energy (Claudia Grotz); 2 - Consequences of the July 10, 2006 wind energy tariff bylaw cancelling (Fabrice Cassin); 3 - Wind energy trajectory in France and Germany: a political perspective (Aurelien Evrard); 4 - The wind energy development areas (Veronique Froeding); 5 - A commitment at the heart of our business: renewable energy sources (Serge Galaup); 6 - The wind energy coordination office (Laure Kaelble); 7 - New challenges of the German wind energy market (Melanie Persem); 8 - An industry - a qualification standard (Yannick Regnier)

  4. Die Reichweite der Haftungsprivilegien nach dem SGB VII außerhalb des klassischen Arbeitsunfalls / Tobias Matz ; Claudia Baumann

    Index Scriptorium Estoniae

    Matz, Tobias

    2016-01-01

    Ettevõtte ja kollektiivi vastutusest sotsiaalseadustiku § 104 jj tähenduses ebatraditsiooniliste tööõnnetuste korral (nt koolides õpilaste/õpetajate vigastused; praktikandid kutseõppes; loomade tekitatud vigastused jms)

  5. The pedagogy and aesthetic representations of ambience: architecture magazines in the late 20th century in Brazil

    Directory of Open Access Journals (Sweden)

    Rafael Alves Pinto Júnior

    2013-06-01

    Full Text Available La preocupación por mantener a los consumidores bien informados sobre los modelos de buen gusto imperantes ha estado presente en prácticamente todo el periodismo temático, y siguió así de manera inalterable en la “condición” post-moderna de la década de 1980. Para las revistas dedicadas a la arquitectura y dirigidas al público en general - como Casa e Jardim, Casa Claudia y Arquitetura & Construção -, ese fenómeno adquirió peculiaridades de un eclecticismo enciclopédico, a fines del siglo 20 en Brasil. Con esto, lograron mantenerse en el selecto grupo de publicaciones clasificadas como “dictadoras del gusto”, producidas en São Paulo, y que irradiaban para todo el País.

  6. Introduction. Socialist Culture and Modernity

    Directory of Open Access Journals (Sweden)

    Joes Segal

    2014-11-01

    Full Text Available From October 6th to 11th, 2013, the MS Gretha van Holland brought twenty-four conference participants from Berlin to Beeskow, Eisenhüttenstadt, Frankfurt/Oder and back to Berlin. The aim of this on-board boat conference, organised by Art Archive Beeskow and Utrecht University in collaboration with Marlene Heidel, Claudia Jansen and Ursula Lücke, was to cross borders – national and disciplinary – by connecting parallel and divergent European histories of the Cold War period, both on a conceptual and on a practical level. A selected group of historians, art historians, architectural historians, cultural anthropologists and visual artists discussed the various ways in which socialist cultural history has been presented over the past decades and put new perspectives to the test. This conference has resulted in the present issue of HCM.

  7. The Role of the Senses in the Early Modern Italian Garden

    DEFF Research Database (Denmark)

    Knudsen, Karin Esmann

    According to the Italian humanists gardens can be regarded as a third nature (John Dixon Hunt: Greater Perfections 2000, Claudia Lazzaro: The Italian Renaissance Garden 1990). Different from the first nature, wilderness, and the second nature, the cultural landscape (Cicero) gardens are a special...... combination of nature and culture, more sophisticated, more deliberate, more complex in the mixture of culture and nature. In the Italian renaissance garden this third nature reached an artificial and aesthetic level as a pleasure garden which made use of all the senses, and in doing so it played an important...... role in constructing new conceptions of the connection between man and nature. This presentation will examine how the gardens around Italian Renaissance villas in Tuscany and in the surroundings of Rome, with their use of geometrical lay-out, water, sounds, views, plants and buildings not only...

  8. Accountability, Italian style: how to reply to government pressure?

    Directory of Open Access Journals (Sweden)

    Mauro M

    2015-09-01

    Full Text Available Marianna Mauro, Giovanna TalaricoDepartment of Clinical and Experimental Medicine, Magna Græcia University of Catanzaro, Catanzaro, ItalyAbstract: The current paper addresses the complex issue of accountability by focusing on Italian public hospitals and teaching hospitals; it aims to analyze Italian health care organizations' strategies for responding to the pressure generated by regulations. In particular, in the last few years, Italian hospitals and teaching hospitals have been obliged to implement or improve their accountability instruments in response to a new regulation (known as the Brunetta reform, Legislative Decree number 150/2009. The Legislative Decree aims to measure and assess the results of each public administration unit in terms of efficiency of the human resources, satisfaction level of the final users, and transparency of its action. Despite the initial consensus on the necessity to make the decision process in health care visible and transparent, health care organizations find it difficult to demonstrate accountability. The present paper summarizes the evidence on the degree of compliance to the reform requirements and will allow an in-depth understanding of Italian health organizations' attitudes toward accountability. This study will help policymakers understand the degree of acceptance and application of the new reforms and assess whether the law/regulations may be effective drivers for disseminating a culture of transparency and accountability.Keywords: transparency, Italian health care, law/regulations, compliance

  9. Update on critical evidence for use of carnitine analogs in clinical practice in CNS disorders

    Directory of Open Access Journals (Sweden)

    Traina G

    2011-04-01

    Full Text Available Giovanna TrainaDepartment of Economics and Food Sciences, University of Perugia, Perugia, ItalyAbstract: L-carnitine (LC is part of the carnitine shuttle system at the mitochondrial inner membrane (MIM and transports long chain fatty acids over the MIM route. Acetyl-L -carnitine (ALC, the acetyl ester of LC, plays an essential role in intermediary metabolism. To ALC are ascribed neurotrophic actions, antioxidant and antiapoptotic activity, positive effects on mitochondrial metabolism, and stabilization of intracellular membranes. Acylcarnitine and LC supplementation have shown beneficial effects in the treatment of aging, chronic degenerative pathologies and the slowing of the progression of mental deterioration in neurodegenerative diseases, and painful neuropathies. ALC is reported to affect brain energy and phospholipid metabolism and to interact with cell membranes, proteins, and enzymes. It also shows a neuromodulatory effect on synaptic morphology and neurotransmitter synaptic transmission, including that of acetylcholine and dopamine. All these data suggest that ALC can affect several targets in the central nervous system. The roles and effects of LC and ALC have led researchers to investigate carnitine's involvement in a variety of neuropathological states and treatments, including autism, Parkinson's disease, Alzheimer's disease, Down's syndrome, Huntington's disease, cerebellar ataxia, age-associated mental decline, hepatic encephalopathy, and ammonia neurotoxicity. This review summarizes evidence that carnitine analogs play many roles in serious neurological pathologies.Keywords: L-carnitine, acetyl-L-carnitine, brain, neural disorders

  10. Feasibility of visual aids for risk evaluation by hospitalized patients with coronary artery disease: results from face-to-face interviews

    Directory of Open Access Journals (Sweden)

    Magliano CAS

    2018-05-01

    Full Text Available Carlos Alberto da Silva Magliano,1 Andrea Liborio Monteiro,2 Bernardo Rangel Tura,1 Claudia Silvia Rocha Oliveira,1 Amanda Rebeca de Oliveira Rebelo,1 Claudia Cristina de Aguiar Pereira3 1NATS, Instituto Nacional de Cardiologia, INC, Rio de Janeiro, Rio de Janeiro, Brazil; 2Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA; 3Escola Nacional de Saúde Pública, ENSP, FIOCRUZ, Rio de Janeiro, Brazil Purpose: Communicating information about risk and probability to patients is considered a difficult task. In this study, we aim to evaluate the use of visual aids representing perioperative mortality and long-term survival in the communication process for patients diagnosed with coronary artery disease at the National Institute of Cardiology, a Brazilian public hospital specializing in cardiology. Patients and methods: One-on-one interviews were conducted between August 1 and November 20, 2017. Patients were asked to imagine that their doctor was seeking their input in the decision regarding which treatment represented the best option for them. Patients were required to choose between alternatives by considering only the different benefits and risks shown in each scenario, described as the proportion of patients who had died during the perioperative period and within 5 years. Each participant evaluated the same eight scenarios. We evaluated their answers in a qualitative and quantitative analysis. Results: The main findings were that all patients verbally expressed concern about perioperative mortality and that 25% did not express concern about long-term mortality. Twelve percent considered the probabilities irrelevant on the grounds that their prognosis would depend on “God’s will.” Ten percent of the patients disregarded the reported likelihood of perioperative mortality, deciding to focus solely on the “chance of being cured.” In the quantitative analysis, the vast

  11. Ethics, design and planning of the built environment

    CERN Document Server

    Moroni, Stefano

    2013-01-01

    The book proposes a set of original contributions in research areas shared by planning theory, architectural research, design and ethical inquiry. The contributors gathered in 2010 at the Ethics of the Built Environment seminar organized by the editors at Delft University of Technology. Both prominent and emerging scholars presented their researches in the areas of aesthetics, technological risks, planning theory and architecture. The scope of the seminar was highlighting shared lines of ethical inquiry among the themes discussed, in order to identify perspectives of innovative interdisciplinary research. After the seminar all seminar participants have elaborated their proposed contributions. Some of the most prominent international authors in the field were subsequently invited to join in with this inquiry. Claudia Basta teaches "Network Infrastructures and Mobility" at Wageningen University. Between 2009 and 2011 she worked as Coordinator of the 3TU Centre of Excellence for Ethics and Technology of Delft Un...

  12. Visit of UK firms at CERN

    CERN Multimedia

    FP Department

    2011-01-01

    24 – 25 NOVEMBER 2011 09h00 to 17h00 Thursday 24 November 09h00 to 17h00 Friday 25 November Individual interviews will take place in technicians’ offices. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details which are available from each secretariat of department or from the GS Department web pages at the following URL: http://gs-dep.web.cern.ch/en/content/Industrial-Exhibitions List of Companies: • AWS Electronics • Cryogenic • Hytec Electronics • Industrial Electronic Wiring • M G Sanders • MDC Vacuum • MM Microwave • Premier Building and Engineering • Russel Ductile Castings • Tadley Engineering • NDSL For further information please contact Claudia Bruggmann Furlan GS-IS-LS 73312 or Caroline Laignel GS-DI 73722.

  13. Pictures of the month

    CERN Multimedia

    Claudia Marcelloni de Oliveira

    Starting with this issue, we will publish special pictures illustrating the ongoing construction and commissioning efforts. If you wish to have a professionnal photographer immortalize your detector before it disappears in the heart of ATLAS or for a special event, don't hesitate to contact Claudia Marcelloni de Oliveira (16-3687) from the CERN photo service. Members of the pixel team preparing to insert the outermost layer (the outer of the three barrel pixel layers) into the Global Support Frame for the Pixel Detector in SR1. Ongoing work on the first Big Wheel on the C side. Exploded view of the side-C Big Wheel and the barrel cryostat. The TRT Barrel services (HV, LV, cooling liquid, active gas, flushing gas) are now completely connected and tested. Hats off to Kirill Egorov, Mike Reilly, Ben Legeyt and Godwin Mayers who managed to fit everything within the small clearance margin!

  14. Ricerca, tutela e valorizzazione del patrimonio archeologico: opinioni a confronto / Research, protection and enhancement of archaeological heritage: comparing different point of views

    Directory of Open Access Journals (Sweden)

    Carmelo Grasso

    2016-12-01

    We publish here the speeches, reviewed by the authors, presented on the 7th of April 2016 at the workshop in honor of Claudia Giontella, dedicated to the social, cultural, political and economic challenges that archeology is called to face in this new century. The first two speeches examine the Italian protection system in the light of some recent innovations: after showing the activity of the “Comando Carabinieri per la Tutela del Patrimonio Culturale”, Carmelo Grasso illustrates the creation in 2015 of a new national task force, operating in situations of natural disasters and wars (“Caschi Blu della Cultura”, while Mario Pagano evaluates the Reform of MiBACT. Then, Paolo Güll discusses theoretical and methodological issues concerning preventive archeology, and Francesca Sogliani focuses on activities that have been promoted to enhance archeological heritage in Basilicata, also in sight of Matera European Cultural Capital 2019.

  15. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Switzerland (please sp...

  16. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Swi...

  17. Electricity and the Technology–Skill Complementarity: Evidence from the Swedish Industrial Census of 1931

    Directory of Open Access Journals (Sweden)

    Svante Prado

    2017-04-01

    Full Text Available Notwithstanding the popularity among economists of attributing the surging inequality of recent decades to technology–skill complementarity, researchers with a keen eye on history have been reluctant to pick up this thread. This paper joins Claudia Goldin and Lawrence Katz’s attempt to examine the role of electrification as an example of a technology that is complementary to workers’ rising skill levels. Sweden electrified manufacturing processes rapidly in the first quarter of the twentieth century, while the supply of skills through secondary education only increased significantly in the 1950s. We use industry-specific information from the Swedish Industrial Census of 1931 to establish whether electricity and the use of white-collar workers correlated positively. The results indicate that the correlation was positive, but the estimated effect was rather small. Moreover, the available evidence for skill ratios does not suggest that inequality, thus measured, increased. We conclude that labor market institutions prevented—and also overturned—the inequality push emanating from technology.

  18. Behind the machines

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    One of the first things we think about when someone mentions physics is the machines. But behind the machines, there are the men and women who design, build and operate them. In an exhibition at the Thinktank planetarium’s art gallery in Birmingham (UK), Claudia Marcelloni and her husband Neal Hartman—she is a photographer and Outreach Officer for ATLAS, while he is an engineer working on the ATLAS pixel detector—explore the human side of scientists.   The exhibition at the Thinktank Planetarium art gallery, Birmingham (UK). It all began two years ago with the publication of Exploring the mystery of matter, a book about ATLAS. “A Norwegian physicist friend, Heidi Sandaker, saw my photographs and suggested that I display them in a museum. I thought this was an interesting idea, except that the photos consisted entirely of depictions of machinery, with human beings completely absent. For me, showing the people who are behind the machines and the fascination ...

  19. Danish firms visit CERN

    CERN Multimedia

    FP Department

    2011-01-01

    30 – 31 JANUARY 2012 09:00 to 17:00 Monday 30 January 09:00 to 17:00 Tuesday 31 January Individual interviews will take place in technicians’ offices. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details available from the secretariat of their department or from the GS Department web page. List of Companies: · Axcon APS · BB Electronics A/S · B.Rustfrit Stal A/S · CIM Industrial Systems A/S · Danfysik A/S · Develco A/S · Eletronic A/S · GPV Group · Innoware A/S · JLI Vision A/S · NECAS A/S· NKT Cables A/S · Noliac A/S · Prodan A/S · Röttger’s Vaerktoj A/S · Vengcon APS For further information please contact Claudia Bruggmann Furlan  GS-IS-LS 73312 or Caroline Laignel GS-DI 73722.

  20. Visit of Danish firms at CERN

    CERN Multimedia

    GS Department

    2012-01-01

    30 – 31 JANUARY 2012 09h00 to 17h00 Monday 30 January 09h00 to 17h00 Tuesday 31 January Individual interviews will take place in technicians’ offices. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details which are available from each secretariat of department or from the GS Department web pages at the following URL http://gs-dep.web.cern.ch/en/content/Industrial-Exhibitions List of Companies: Axcon APS BB Electronics A/S B.Rustfrit Stal A/S CIM Industrial Systems A/S Danfysik A/S Develco A/S Eletronic A/S GPV Group Innoware A/S JLI Vision A/S NECAS A/S NKT Cables A/S Noliac A/S Röttger’s Vaerktoj A/S   For further information please contact Claudia Bruggmann Furlan  GS-IS-LS 73312 or Caroline Laignel GS-DI 73722.

  1. Affect and self-efficacy infuse the experience of ambivalent photographs

    Directory of Open Access Journals (Sweden)

    Muth Claudia

    2017-01-01

    Full Text Available Ambivalent pictures offer several interpretations of different valence-e.g., some photographs by Claudia Otto document scenes which can be perceived as sad or happy, dangerous or sweet, and so on. We show that task experiences influence the experienced valence of these images. Previous work already documented that responses to images are task-dependent and self-created insights heighten pleasure. A resulting positive mood and high self-efficacy might broaden attention to positive valence. In contrast, low self-efficacy leads to the prediction of negative task experiences and strengthens the salience of a positive experience. In our study, participants rated the valence of ambivalent photographs to be more positive after positive feedback regarding the accomplishment of a precedent puzzle. We revealed a trend of positive feedback being more effective when it followed negative experiences. The experience of ambivalent images is strongly linked to mood and self-efficacy and both is influenced by taskexperiences in psycho-aesthetic studies.

  2. Preparing a new book on ATLAS

    CERN Multimedia

    Claudia Marcelloni de Oliveira

    A book about the ATLAS project and the ATLAS collaboration is going to be published and available for sale in mid 2008. The book is intended to be a symbol of appreciation for all the people from ATLAS institutes, triggering fond memories through photos, interviews, short commentaries and anecdotes about the daily life and milestones encountered while designing, constructing and completing ATLAS. We would like to give you the opportunity to collaborate with this project in two different ways: Firstly, please send us the best anecdotes related to ATLAS that you remember. To submit anecdotes, send an email to Claudia.Marcelloni@cern.ch. Secondly, you are invited to participate in our PHOTO COMPETITION. Please send the best photos you have of ATLAS attached with a description, the location, and date taken. The categories are: Milestones in the process of designing and building the detector, People at work and Important gatherings. To submit photos you should go to the CDS page and select ATLAS Photo Competi...

  3. Experimental and analytical studies on waterhammer generated by the closing of check valves

    International Nuclear Information System (INIS)

    Huet, J.L.; Garcia, J.L.; Coppolani, P.; Ziegler, B.

    1987-01-01

    A double-guillotine rupture on a water line upstream from a check valve generates a severe transient between the check valve and the pressure vessel on the downstream side. Successively following phenomena occur: - decrease then reversal of the flow, - closing of the check valve with impact of the plug on its seat, - waterhammer propagating in the pipe downstream from the check valve. The COMMISARIAT A L'ENERGIE ATOMIQUE (C.E.A.) FRAMATOME and ELECTRICITE DE FRANCE (E.D.F.) have undertaken a joint program in order to: - investigate the behavior uf the check valve in the event of a sudden closure, - evaluate the pressure and flow transient in the line. The program includes: - full scale tests in two loops, CLAUDIA (C.E.A.) and ECLAIR (E.D.F.), - analytical studies in order to qualify the calculation codes. This paper describes the experimental program and presents the analysis results for a benchmark test

  4. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    2004-01-01

    Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrate unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). • 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) • 10:30 - 10:45 coffee • 10:45 - 13:00 (second part)...

  5. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrates unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) 10:30 -...

  6. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    2004-01-01

    Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrate unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). • 09:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) • 10:30 - 10:45 coffee • 10:45 - 13:00 (second part)...

  7. Happy birthday, Jack Steinberger

    CERN Multimedia

    CERN Bulletin

    2016-01-01

    Even if he’s recently stopped coming to CERN on his bike, Jack Steinberger and his piercing blue eyes are still regular visitors to our corridors. As he celebrates his 95th birthday, we pay tribute to one of CERN’s greatest scientists.   Jack Steinberger in 2008, pictured on the occasion of the "Accelerating Nobel" exhibition. (Image: Claudia Marcelloni/CERN) Jack emigrated from Germany to the United States in 1934 to escape the persecution of the Jews. He later went on to study under Enrico Fermi in Chicago and in the 1950s, he contributed to the development of bubble chambers. Using this new detection apparatus, he was involved in the myriad discoveries and results that led to the construction of the Standard Model. In 1961, while at Columbia University (New York), he took part in the first experiment with a high-energy neutrino beam, which gave rise to the discovery of the muon neutrino. This discovery was awarded the&a...

  8. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  9. TEDx Organisers meet at CERN

    CERN Multimedia

    Abha Eli Phoboo

    2013-01-01

    CERN hosted the second TEDx European Organisers meeting last week with around 80 organisers attending from all over Europe. They were given an introduction to CERN and a tour of the LHC experiments.   The participants of the TEDx European Organisers meeting held at CERN last week. Among the attendees was Bruno Giussani, European director of TED, who delivered the welcome address. The TEDx European organisers shared their experiences in workshops and brainstormed about how to work on different aspects of organising a TEDx event, and about improving the relationship between TEDx and TED. “The goal of this meeting was for veteran TEDx organisers to help younger ones, help each other, bring the community together and have better quality events,” said Claudia Marcelloni, head of TEDxCERN. TEDx is an independently organised TED (Technology, Entertainment, Design) talk event, which has grown exponentially all over the world. There are hundreds of TEDx events every day and it n...

  10. CERN inspires 2011 edition of the ARS Electronica Digital Arts Festival

    CERN Multimedia

    Jordan Juras

    2011-01-01

    This year’s annual ARS Electronica Digital Arts Festival featured CERN as the springboard for its theme, ORIGIN – How it All Begins. The prestigious digital arts festival also served as the perfect venue to launch the Collide@CERN project.   Colours and Lights at the ARS Electronica Digital Arts Festival in Linz (Austria). (Photo by Claudia Marcelloni) The CERN cultural policy project, announced at the beginning of 2011 has started to gain momentum. Ariane Koek, art specialist for the Communication Group, received confirmation in May that ARS Electronica had chosen her proposal to use CERN as the primary source of inspiration for their annual ARS Electronica Festival. This marks the first of the cultural policy’s arts partnerships. The world-renowned celebration for the digital arts is held annually in Linz, Austria, where, amongst the incredible collection of displays and productions, the Prix ARS Electronica – the Oscars of the digital arts world -&...

  11. El taller de las estatuas togadas de Ronda de Tejares (Córdoba

    Directory of Open Access Journals (Sweden)

    López López, Isabel M.ª

    1998-12-01

    Full Text Available The style and carving technique of a group of eleven togate statues dating to the reign of Claudius I from Colonia Patricia point to their being the product of a single workshop. The quality of the workmanship, their size, and the choice of material suggest that the sculptures were either of members of the Julio-Claudian dynasty or of summi viri, an interpretation reinforced by their location in one of the colony's principal public spaces.En este artículo presentamos un conjunto de once estatuas togadas de plena época Claudia procedentes de Colonia Patricia. Sus características estilísticas y sus rasgos de factura nos permiten identificarlas como producción de un mismo taller escultórico. Asimismo la calidad, dimensiones y material contribuyen a interpretarlas como representaciones de miembros de la dinastía julioclaudia, o bien de summi viri, siendo ubicadas en uno de los principales espacios públicos de la ciudad.

  12. Development of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency

    Directory of Open Access Journals (Sweden)

    Claudia A Montiel-Equihua

    2009-12-01

    Full Text Available Claudia A Montiel-Equihua, Adrian J Thrasher, H Bobby GasparCentre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, UKAbstract: The history of stem cell gene therapy is strongly linked to the development of gene therapy for severe combined immunodeficiencies (SCID and especially adenosine deaminase (ADA-deficient SCID. Here we discuss the developments achieved in over two decades of clinical and laboratory research that led to the establishment of a protocol for the autologous transplant of retroviral vector-mediated gene-modified hematopoietic stem cells, which has proved to be both successful and, to date, safe. Patients in trials in three different countries have shown long-term immunological and metabolic correction. Nevertheless, improvements to the safety profile of viral vectors are underway and will undoubtedly reinforce the position of stem cell gene therapy as a treatment option for ADA-SCID.Keywords: adenosine deaminase, severe combined immunodeficiency, gene therapy, hematopoietic stem cell, retrovirus, clinical trial

  13. Patient and physician preferences for attributes of coronary revascularization

    Directory of Open Access Journals (Sweden)

    Magliano CAS

    2018-05-01

    Full Text Available Carlos Alberto da Silva Magliano,1 Andrea Liborio Monteiro,2 Bernardo Rangel Tura,1 Claudia Silvia Rocha Oliveira,1 Amanda Rebeca de Oliveira Rebelo,1 Claudia Cristina de Aguiar Pereira3 1HTA Department, National Institute of Cardiology, Rio de Janeiro, Brazil; 2Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA; 3The National School of Public Health Sergio Arouca ENSP/Fiocruz, Rio de Janeiro, Brazil Background: Patients with a diagnosis of coronary artery disease (CAD may face important decisions regarding treatment options, with the “right choice” depending on the relative weights of risks and benefits. Studies performed as discrete choice experiments are used to estimate these weights, and attribute selection is an essential step in the design of these studies. Attributes not included in the design cannot be analyzed. In this study, we aimed to elicit, rank, and rate attributes that may be considered important to patients and physicians who must choose between angioplasty and surgery for coronary revascularization. Methods: The elicitation process involved performing a systematic review to search for attributes cited in declared preference studies in addition to face-to-face interviews with cardiologists and experts. The interviews were audio-recorded in digital format, and the collected data were transcribed and searched to identify new attributes. The criterion used to finish the data collection process was sampling saturation. Results: A systematic review resulted in the selection of the following 14 attributes: atrial fibrillation, heart failure, incision scar, length of stay, long-term survival, myocardial infarction, periprocedural death, postoperative infection, postprocedural angina, pseudoaneurysm, renal failure, repeat coronary artery bypass grafting, repeat percutaneous coronary intervention, and stroke. The interviews added no new attributes. After

  14. Profile of sugammadex for reversal of neuromuscular blockade in the elderly: current perspectives

    Directory of Open Access Journals (Sweden)

    Carron M

    2017-12-01

    Full Text Available Michele Carron, Francesco Bertoncello, Giovanna Ieppariello Department of Medicine, Anesthesiology, and Intensive Care, University of Padova, Padua, Italy Abstract: The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of perioperative morbidity and mortality. Complications related to postoperative residual neuromuscular blockade, such as muscle weakness, airway obstruction, hypoxemia, atelectasis, pneumonia, and acute respiratory failure, are more frequent in older than in younger patients. Therefore, neuromuscular blockade in the elderly should be carefully monitored and completely reversed before awakening patients at the end of anesthesia. Acetylcholinesterase inhibitors are traditionally used for reversal of neuromuscular blockade. Although the risk of residual neuromuscular blockade is reduced by reversal with neostigmine, it continues to complicate the postoperative course. Sugammadex represents an innovative approach to reversal of neuromuscular blockade induced by aminosteroid neuromuscular-blocking agents, particularly rocuronium, with useful applications in clinical practice. However, aging is associated with certain changes in the pharmacokinetics of sugammadex, and to date there has been no thorough evaluation of the use of sugammadex in elderly patients. The aim of this review was to perform an analysis of the use of sugammadex in older adults based on the current literature. Major issues surrounding the physiologic and pharmacologic effects of aging in elderly patients and how these may impact the routine use of sugammadex in elderly patients are discussed. Keywords: sugammadex, aging, elderly, neuromuscular blockade, rocuronium, anesthesia, safety

  15. TECHNICAL TRAINING SEMINAR: National Instruments

    CERN Multimedia

    Monique Duval

    2004-01-01

    From 9:30 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Data acquisition systems on PCs, industrial measurement and control techniques, advanced LabVIEW software and PXI instrumentation, and system components for tests and automation will be presented. Walk-in courses will address DIAdem, LabVIEW and data acquisition. Language: English and French Free seminars and courses, no registration Organisers: Rolf Stampfli / IT-CO / 78102 & 160367 / Rolf.Stampfli@cern.ch Davide Vitè / HR-PMD-ATT / 75141 Davide.Vite@cern.ch For more information and the complete event programme, please visit the...

  16. ATLAS book wins the IPPY awards

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    Hunting the Higgs, published by Papadakis Publishers in collaboration with the ATLAS experiment has won the Bronze prize in the Science category of the Independent Publisher Book Awards (see here). The Award ceremony will be held on 28 May in New York on the eve of the BookExpo America (see here).   “Ours is a souvenir book that gives viewers a glimpse of the discovery of the Higgs boson and the collaborative effort behind it of thousands of scientists in ATLAS,” says Claudia Marcelloni, communications officer of the ATLAS Experiment, who worked on the book with freelance science writer Colin Barras. “The science is noble and the collaboration heartwarming, and the IPPY Award is a great way to celebrate the mind-blowing story of human achievement.” Hunting the Higgs is the inside story of the ATLAS experiment at the Large Hadron Collider. It tells the journey of the experiment, from before the detector was born to the announcement of the discovery of t...

  17. A viagem como experiência traumática na ficção Paisagem de Porcelana de Cláudia NIna

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    Bruno Cardoso

    2017-10-01

    Full Text Available O artigo analisa a representação da experiência de deslocamento no romance Paisagem de Porcelana da escritora carioca Claudia Nina. A leitura da obra focaliza os expedientes narrativos empregados pela autora no objetivo de figurar a viagem da protagonista-narradora a Holanda sob uma moldura traumática e dramática. Assim, o enredo se constrói sob uma perspectiva memorialista, conforme Cury( 2016, comumente utilizada em narrativas de viagem. A hipótese de leitura assume que a narradora, ao passo que rememora os acontecimentos traumáticos ocorridos em sua experiência de viagem a Amsterdã, produz um discurso de ficção reparando as arestas deixadas pela experiência traumática. Em consequência disso,, a possibilidade de superar a experiência traumática de viagem se viabiliza, no romance, por intermédio da criação de uma escrita ficcional sobre ela,o que se  revela como estratégia narrativa crucial para a construção do enredo.

  18. Persuasive Strategies towards Racial Appeal in Tony Morrison’s The Bluest Eye

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    Somayeh Shabani

    2017-12-01

    Full Text Available Racism is the main theme in Toni Morisson’s The Bluest Eye. The little black girl’s long lasting yearn for blue eyes has been linked to the standards of America’s society in 1940’s which associated beauty to being white. Although instances of racism are rampant throughout the story, previous studies have not attempted to determine the type of persuasive strategies used by Toni Morrison to justify racism in the novel. In this paper, the author made use of Aristotle’s concepts of ethos, logos, and pathos, as 3 main dimensions of persuasion to determine the strategies used in the novel by the narrator-Claudia. Descriptive qualitative analysis of the novel’s text revealed that the author has made use of all these strategies. Pathos was observed in form of feelings of fear, anger and hatred. Logos was observed in the logic of the grown up society of America about being white and ethos was found among the black who themselves credited the whites over their own race.

  19. Daphnia magna and Xenopus laevis as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625

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    Galdiero E

    2017-04-01

    Full Text Available Emilia Galdiero,1 Annarita Falanga,2 Antonietta Siciliano,1 Valeria Maselli,1 Marco Guida,1 Rosa Carotenuto,1 Margherita Tussellino,1 Lucia Lombardi,3 Giovanna Benvenuto,4 Stefania Galdiero2 1Department of Biology, 2Department of Pharmacy and CiRPEB, University of Naples Federico II, 3Department of Experimental Medicine, Second University of Naples, 4Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy Abstract: The use of quantum dots (QDs for nanomedicine is hampered by their potential toxicologic effects and difficulties with delivery into the cell interior. We accomplished an in vivo study exploiting Daphnia magna and Xenopus laevis to evaluate both toxicity and uptake of QDs coated with the membranotropic peptide gH625 derived from the glycoprotein H of herpes simplex virus and widely used for drug delivery studies. We evaluated and compared the effects of QDs and gH625-QDs on the survival, uptake, induction of several responsive pathways and genotoxicity in D. magna, and we found that QDs coating plays a key role. Moreover, studies on X. laevis embryos allowed to better understand their cell/tissue localization and delivery efficacy. X. laevis embryos raised in Frog Embryo Teratogenesis Assay-Xenopus containing QDs or gH625-QDs showed that both nanoparticles localized in the gills, lung and intestine, but they showed different distributions, indicating that the uptake of gH625-QDs was enhanced; the functionalized QDs had a significantly lower toxic effect on embryos’ survival and phenotypes. We observed that D. magna and X. laevis are useful in vivo models for toxicity and drug delivery studies. Keywords: membranotropic peptide, delivery, blood–brain barrier, nanoparticles, genotoxicity

  20. Lomi And Totò : An Ethiopian-Italian Colonial or Postcolonial “Love Story”?

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    Giovanna Trento

    2007-01-01

    Full Text Available Lomi and Totò. An Ethiopian-Italian Colonial or Postcolonial “Love Story”? introduces various and still open questions related to the current necessity of a deeper study of the Italian colonial presence in the African Horn. The source of this article is the relationship between Lomi and Totò, an Ethiopian woman and an Italian man who are not alive anymore, as it is seen and told by their five children (with some additional illuminating interviews. This story started during the Italian colonial fascist period, continued in the Fifties and Sixties in postcolonial East Africa, ended up in Italy in the Eighties, and is still alive in the memory of Lomi and Totò descendents. This “love story” has different shades and can be read from several points of view: personal, sentimental, familiar, social, anthropological, and historical. For some aspects it is unique, but for others it is exemplary of its time and allows us to look into important dynamics during wide and complex periods. Giovanna Trento in this article, thanks to the observation of this “private history”, highlights a certain controversial and unstable degree of fluidity between colonial and postcolonial periods, also questioning the degree of freedom individuals might have within a given social framework, thus suggesting some crucial and sometimes ambiguous issues related to: the use of racial laws in the fascist period; notions of concubinage, marriage and citizenship; gender and power relations; subaltern conditions and marginality within Italian colonialism; discrepancies between portraying African women and relating to them; new African-Italian identities; building collective memory and family storytelling; reproducing, suffering, or overcoming the “colony” today.

  1. PREFACE: IUPAP C20 Conference on Computational Physics (CCP 2011)

    Science.gov (United States)

    Troparevsky, Claudia; Stocks, George Malcolm

    2012-12-01

    . We are grateful to the committees that helped put the conference together, especially the local organizing committee. Particular thanks are also due to a number of ORNL staff who spent long hours with the administrative details. We are pleased to express our thanks to the conference administrator Ann Strange (ORNL/CDP) for her responsive and efficient day-to-day handling of this event, Sherry Samples, Assistant Conference Administrator (ORNL), Angie Beach and the ORNL Conference Office, and Shirley Shugart (ORNL) and Fern Stooksbury (ORNL) who created and maintained the conference website. Editors: G Malcolm Stocks (ORNL) and M Claudia Troparevsky (UT) http://ccp2011.ornl.gov Chair: Dr Malcolm Stocks (ORNL) Vice Chairs: Adriana Moreo (ORNL/UT) James Guberrnatis (LANL) Local Program Committee: Don Batchelor (ORNL) Jack Dongarra (UTK/ORNL) James Hack (ORNL) Robert Harrison (ORNL) Paul Kent (ORNL) Anthony Mezzacappa (ORNL) Adriana Moreo (ORNL) Witold Nazarewicz (UT) Loukas Petridis (ORNL) David Schultz (ORNL) Bill Shelton (ORNL) Claudia Troparevsky (ORNL) Mina Yoon (ORNL) International Advisory Board Members: Joan Adler (Israel Institute of Technology, Israel) Constantia Alexandrou (University of Cyprus, Cyprus) Claudia Ambrosch-Draxl (University of Leoben, Austria) Amanda Barnard (CSIRO, Australia) Peter Borcherds (University of Birmingham, UK) Klaus Cappelle (UFABC, Brazil) Giovanni Ciccotti (Università degli Studi di Roma 'La Sapienza', Italy) Nithaya Chetty (University of Pretoria, South Africa) Charlotte Froese-Fischer (NIST, US) Giulia A. Galli (University of California, Davis, US) Gillian Gehring (University of Sheffield, UK) Guang-Yu Guo (National Taiwan University, Taiwan) Sharon Hammes-Schiffer (Penn State, US) Alex Hansen (Norweigan UST) Duane D. Johnson (University of Illinois at Urbana-Champaign, US) David Landau (University of Georgia, US) Joaquin Marro (University of Granada, Spain) Richard Martin (UIUC, US) Todd Martinez (Stanford University, US) Bill

  2. Imitation and communication skills development in children with pervasive developmental disorders

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    Andrea De Giacomo

    2009-06-01

    Full Text Available Andrea De Giacomo1, Claudia Portoghese1, Domenico Martinelli2, Isabella Fanizza1, Luciano L’Abate3, Lucia Margari11Child Neurological and Psychiatric Unit, Department of Neurological and Psychiatric sciences, University of Bari, Italy; 2Department of Biomedical science and Oncology, University of Bari, Italy; 3Department of Psychology, Georgia State University Abstract: This study evaluates the correlation between failure to develop spontaneous imitation and language skills in pervasive developmental disorders. Sixty-four children between the age of 3 and 8 years were assessed using the Autism Diagnostic Interview-Revised (ADI-R, the Childhood Autism Rating Scale (CARS, and the Autism Diagnostic Observation Schedule (ADOS, as well as direct observation of imitation. The sample was subdivided into a verbal and a nonverbal group. Analysis of mean scores on the CARS “imitation” items and of ADI-R “spontaneous imitation” and “pointing to express interest” revealed a statistically significant difference between verbal and nonverbal groups, with more severe impairment/higher scores in the nonverbal than the verbal group. These results suggest that nonverbal children have specifically impaired imitation and pointing skills.Keywords: autism, imitation, communication, language, pointing

  3. Gastrointestinal obstruction caused by solidification and coagulation of enteral nutrition: pathogenetic mechanisms and potential risk factors

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    Leonello G

    2018-04-01

    Full Text Available Grazia Leonello,1 Antonio Giacomo Rizzo,1 Viviane Di Dio,2 Antonio Soriano,3 Claudia Previti,3 Grazia Giulia Pantè,3 Claudio Mastrojeni,1 Sebastiano Pantè1 1Department of Human Pathology of Adults and Evolutive Era “Gaetano Barresi”, University of Messina, Messina, Italy; 2Health Research Institute Bonino Pulejo, Piemonte Hospital, Messina, Italy; 3Department of Medical and Surgery Science, University of Messina, Messina, Italy Abstract: Enteral nutrition (EN is preferred in order to provide nutrition and reduce catabolism in critically ill patients. Recent studies suggest that the use of EN is successful and complications are rare. However, an underestimated mechanical complication of tube feedings seen in critically ill patients is the coagulation and solidification of the EN causing gastrointestinal obstruction. This report describes two clinical cases (1.23% of all cases seen at our clinic of obstruction and perforation of the small bowel secondary to the solidification of EN. The understanding and early recognition of this potential complication are essential for the prevention and successful treatment of this condition. Keywords: enteral nutrition, gastrointestinal contents, intestinal obstruction, small-bowel bezoar

  4. La junta luz di Juan Gelman: un oratorio contro il silenzio

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    Arianna Fiore

    2014-12-01

    Full Text Available Juan Gelman is generally considered by critics to be one of the most important poets of modern Argentina. Born in Buenos Aires in 1930 from Russian-Jewish parents, he published his first collection of poems (Violín y otras cuestiones in 1956. He is a member of the generación del 60, made up of intellectuals influenced in their critical realism by the charisma of Raúl González Tuñón, forerunner of Argentina’s social and political poetry. This group was politically very active, as demonstrated by their experimental language and iconoclastic lyricism. Gelman’s later life was marked by his exile in the wake of the 1976 dictatorship, and by the desaparición of his son Marcelo Ariel, his daughter-in-law Claudia and his grand-daughter Andrea (born in prison. Since then, it was impossible for Juan Gelman to separate his personal plight from Argentina’s historical-political situation, and his poetry became more and more intimate and lyrical, marked by human drama. La junta luz, the author’s only theatre play, was written and published in this second phase.

  5. Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency

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    Danilo Fintini

    2009-07-01

    Full Text Available Danilo Fintini, Claudia Brufani, Marco CappaEndocrinology Unit, “Bambino Gesù” Children’s Hospital-IRCCS, Rome, ItalyAbstract: Growth hormone insensitivity syndrome (GHI or insulin-like growth factor-1 (IGF-1 deficiency (IGFD is characterized by deficit of IGF-1 production due to alteration of response of growth hormone (GH receptor to GH. This syndrome is due to mutation of GH receptor or IGF-1 gene and patients affected showed no response to GH therapy. The only treatment is recombinant IGF-1 (mecasermin, which has been available since 1986, but approved in the United States by the US Food and Drug Administration only in 2005 and in Europe by the European Medicines Agency in 2007. To date, few studies are available on long-term treatment with mecasermin in IGFD patients and some of them have a very small number of subjects. In this review we discuss briefly clinical features of severe primary IGFD, laboratory findings, and indications for treatment. Results of long-term therapy with rhIGF1 (mecasermin in patients affected by severe primary IGFD and possible side effects are explained.Keywords: mecasermin, therapy, Laron syndrome, IGF-1

  6. Rational and Emotional Communication in Advertising in Women's Magazines in Brazil

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    Edward Robinson Marin

    2014-01-01

    Full Text Available This article investigated the incidence of rational and emotional arguments in messages from 5.536 advertisements of six women's magazines in Brazil (Claudia, Nova, Estilo, Marie Claire, Elle and Gloss, published between May / 2008 and August / 2009. The methodology was based on an exploratory study, supported on a scale of 14 items, by Resnik and Stern (1977, which recommend matching appeals to attitude toward the product, that is, use informative advertising, based on rational appeals for products in which the consumer attitude is predominantly cognitive. To assess the emotional content, we used the scale of eight items of Plutchik (1980, represented by the primary emotions - Anger, Fear, Sadness, Disgust, Surprise, Curiosity, Acceptance and Joy. Data analysis included the frequency of the two appeals in the general category (durables, non-durables and services, product, and correspondence analyzes were used to identify the prevalence of two types of arguments in selected magazines. The results show the concentration of ads on non-durable goods, followed by the category of services, that overcomes the advertisings on durables. The study also analyzes the incidence of emotional and rational arguments by product category and by magazine.

  7. EM BUSCA DA HISTORICIDADE DO MUNICÍPIO DE QUEIMADOS: EXPERIÊNCIAS POSSÍVEIS ENTRE A HISTÓRIA PÚBLICA E O ENSINO DE HISTÓRIA

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    Claudia Patrícia de Oliveira Costa Correio

    2015-07-01

    Full Text Available Claudia Patrícia de Oliveira Costa Correio DOI: 10.12957/periferia.2014.17236Durante as entrevistas realizadas junto à população queimadense entre os anos de 2009 e 2013, identificamos significativo desconforto revelado diante do desenvolvimento da cidade. Tal desconforto expressou-se, na fala dos entrevistados, a partir do crescente interesse dos depoentes em compartilhar suas memórias, registrando-as como "uma resposta ou reação, diante das mudanças rápidas e de uma vida sem âncoras ou raízes" (JELIN, 2002, p. 9. Nesse sentido, constatamos que a preocupação de muitos queimadenses, especialmente aqueles cujas trajetórias de vida se caracterizaram pela maior atuação na esfera pública, introduz questões como a importância das memórias para a escrita e o ensino de História, sua divulgação, a patrimonialização cultural e a dívida do presente com o passado.Palavras-chave: Ensino de História; história pública; memória; Queimados

  8. Lóxoro, traces of a contemporary Peruvian genderlect

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    Luis Miguel Rojas-Berscia

    2016-06-01

    Full Text Available Not long after the premiere of Loxoro in 2011, a short-film by Claudia Llosa which presents the problems the transgender community faces in the capital of Peru, a new language variety became visible for the first time to the Lima society. Lóxoro [‘lok.so.ɾo] or Húngaro [‘uŋ.ga.ɾo], as its speakers call it, is a language spoken by transsexuals and the gay community of Peru. The first clues about its existence were given by a comedian, Fernando Armas, in the mid 90’s, however it is said to have appeared not before the 60’s. Following some previous work on gay languages by Baker (2002 and languages and society (cf. Halliday 1978, the main aim of the present article is to provide a primary sketch of this language in its phonological, morphological, lexical and sociological aspects, based on a small corpus extracted from the film of Llosa and natural dialogues from Peruvian TV-journals, in order to classify this variety within modern sociolinguistic models (cf. Muysken 2010 and argue for the “anti-language” (cf. Halliday 1978 nature of it.

  9. Pixel or Paper? Validation of a Mobile Technology for Collecting Patient-Reported Outcomes in Rheumatoid Arthritis.

    Science.gov (United States)

    Epis, Oscar Massimiliano; Casu, Cinzia; Belloli, Laura; Schito, Emanuela; Filippini, Davide; Muscarà, Marina; Gentile, Maria Giovanna; Perez Cagnone, Paula Carina; Venerelli, Chiara; Sonnati, Massimo; Schiavetti, Irene; Bruschi, Eleonora

    2016-11-16

    In the management of chronic disease, new models for telemonitoring of patients combined with the choice of electronic patient-reported outcomes (ePRO) are being encouraged, with a clear improvement of both patients' and parents' quality of life. An Italian study demonstrated that ePRO were welcome in patients with rheumatoid arthritis (RA), with excellent matching data. The aim of this study is to evaluate the level of agreement between electronic and paper-and-pencil questionnaire responses. This is an observational prospective study. Patients were randomly assigned to first complete the questionnaire by paper and pencil and then by tablet or in the opposite order. The questionnaire consisted of 3 independent self-assessment visual rating scales (Visual Analog Scale, Global Health score, Patient Global Assessment of Disease Activity) commonly used in different adult patients, including those with rheumatic diseases. A total of 185 consecutive RA patients were admitted to hospital and were enrolled and completed the questionnaire both on paper and on electronic versions. For all the evaluated items, the intrarater degree of agreement between 2 approaches was found to be excellent (intraclass correlation coefficient>0.75, P<.001). An electronic questionnaire is uploaded in a dedicated Web-based tool that could implement a telemonitoring system aimed at improving the follow-up of RA patients. High intrarater reliability between paper and electronic methods of data collection encourage the use of a new digital app with consequent benefit for the overall health care system. ©Oscar Massimiliano Epis, Cinzia Casu, Laura Belloli, Emanuela Schito, Davide Filippini, Marina Muscarà, Maria Giovanna Gentile, Paula Carina Perez Cagnone, Chiara Venerelli, Massimo Sonnati, Irene Schiavetti, Eleonora Bruschi. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 16.11.2016.

  10. Water erosion and climate change in a small alpine catchment

    Science.gov (United States)

    Berteni, Francesca; Grossi, Giovanna

    2017-04-01

    WATER EROSION AND CLIMATE CHANGE IN A SMALL ALPINE CATCHMENT Francesca Berteni, Giovanna Grossi A change in the mean and variability of some variables of the climate system is expected to affect the sediment yield of mountainous areas in several ways: for example through soil temperature and precipitation peak intensity change, permafrost thawing, snow- and ice-melt time shifting. Water erosion, sediment transport and yield and the effects of climate change on these physical phenomena are the focus of this work. The study area is a small mountainous basin, the Guerna creek watershed, located in the Central Southern Alps. The sensitivity of sediment yield estimates to a change of condition of the climate system may be investigated through the application of different models, each characterized by its own features and limits. In this preliminary analysis two different empirical mathematical models are considered: RUSLE (Revised Universal Soil Loss Equation; Renard et al., 1991) and EPM (Erosion Potential Method; Gavrilovic, 1988). These models are implemented in a Geographical Information System (GIS) supporting the management of the territorial database used to estimate relevant geomorphological parameters and to create different thematic maps. From one side the geographical and geomorphological information is required (land use, slope and hydrogeological instability, resistance to erosion, lithological characterization and granulometric composition). On the other side the knowledge of the weather-climate parameters (precipitation and temperature data) is fundamental as well to evaluate the intensity and variability of the erosive processes and estimate the sediment yield at the basin outlet. Therefore different climate change scenarios were considered in order to tentatively assess the impact on the water erosion and sediment yield at the small basin scale. Keywords: water erosion, sediment yield, climate change, empirical mathematical models, EPM, RUSLE, GIS

  11. Review: Ingrid Miethe, Claudia Kajatin & Jana Pohl (Eds. (2004. Geschlechterkonstruktionen in Ost und West. Biografische Perspektiven [Gender Constructions in East and West. Biographical Perspectives

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    Nicola Döring

    2006-03-01

    Full Text Available This reader contains analyses of gender constructions in East and West Germany from biographical perspectives. It is based on narrative interviews with women and men living in the former East and West. By means of case reconstructions and case comparisons the authors reveal how individuals deal actively with specific societal gender roles. Historical differences between women's movement and feminism in East Germany versus West Germany are knowledgeably described. The book offers a very complex and multilayered theoretical and empirical construction of gender in its diverse dimensions, but men's biographies and men's studies remain marginalized. Men's movements as well as the gay rights movement are blind spots. The gendering of work and the context of European unification are emphasized. URN: urn:nbn:de:0114-fqs0602353

  12. Del tálamo al Túmulo: Clara Jerónima, Vicente Torellas y roque guinart (Don Quijote, II Parte, Caps. 60, 61

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    Stanislav Zimic

    1995-12-01

    Full Text Available Haciéndole ir a D. Quijote por tierras catalanas, Cervantes, ya por su característica preocupación con la autenticidad histórica, debió de considerar oportuno ingeniar un encuentro entre aquél y el bandolero Roque Guinart, protector o amenaza –según el punto de vista­ de la gente de esa región por aquella época. En efecto, en algunos estudios se destaca esta preocupación de Cervantes como justificativa del notorio episodio, aunque sustentada por un deseo simultáneo de contrastar al dinámico, activo, pragmático "caballero" Roque Guinart con D.Quijote, quimérico "caballero andante", anacrónico, inútil frente a los problemas que surgen durante su encuentro. Descartada como ridícula, absurda, la oferta de D. Quijote de socorrer a Claudia Jerónima, "doncella agraviada'', la impotencia, es decir, la superflua existencia de aquel se haría por completo patente, anunciando asi el inminente fin de sus empresas caballerescas. Esta sugerencia resulta plausible, pero no abarca la implicación más significativa de la "inutilidad" de D. Quijote en ésta y algunas otras situaciones semejantes.

  13. An approach to "The Milk of Sorrow" as a hispanic intercultural narrative film

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    Italo Oscar Riccardi León

    2015-09-01

    Full Text Available The following article aims to develop a Hispanic intercultural cinematic study of the film “The Milk of Sorrow,” written and directed by the Peruvian filmmaker Claudia Llosa that was awarded the Golden Bear at the Berlin Film Festival in 2009. The plot of the movie tells the story of Fausta, a young girl descendant of Amerindians who suffers from a rare disease called “milk of sorrow” or “shock syndrome”, the name given to a supposed disease transmitted by fear and suffering of the mother for her child through breast milk reaching the daughters of women who were raped by terrorists or the Peruvian army soldiers in the decade of the eighties, a time of social and political instability in recent history of Peru. The connection between cinema, society and culture emerged significant and close relations from the perspective of an intercultural film that, according Hudson (2010, attempts to translate into images the experience of living between two or more different cultures and societies that view new ways of thinking and knowledge and can be considered a shared movie for people who have suffered displacement and who lived hybrid modes, as the case of the film “the Milk of Sorrow”.

  14. Captivity mark as Foundation of Civil Liability for Risk in Prol Consumer

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    Fernando Antônio de Vasconcelos

    2016-06-01

    Full Text Available The postmodern society can be seen as risk society. From the Ulrich Beck’s idea that the acquired knowledge allows the current development model, but its generates uncontrollable risks, this study attempts to make a validation of trademark captivity theory as the basis for civil liability for risk. The strength of the brands as fundamental goals in today’s economic process is seen as a vector of liability for consumers as a vulnerable class. The difficulty of consumers in the process of accountability for damages suffered in their relations is still present. The supply process is complex and is formed by a network arrangements which stresses the consumer’s vulnerability. The trademark captivity allows the identification of an economic group participants by sharing the brand. The proposal in this article, is to strengthen the idea of   captivity mark as accountability paradigm from the brand with the theory of risk, examining its feasibility framing the sole paragraph of Article 927 of the Brazilian Civil Code.The methodology will be based on a legal-economic aspect and depart from an inductive analysis and bibliographic surveys, with the theoretical framework of Ulrich Beck, Antonny Giddens and Claudia Lima Marques.

  15. Produção de etileno em frutos de ameixeira ‘Prunus domestica’ sujeitos a duas temperaturas de conservação Ethylene production by ‘Prunus domestica’ plums during storage at two different temperatures

    Directory of Open Access Journals (Sweden)

    A.E. Rato

    2007-01-01

    Full Text Available A síntese de etileno em frutos climatéricos tem sido bastante estudada pela influência que tem na conservação dos mesmos. Por esse motivo tem-se tentado através de alterações das condições ambientais, influenciar a produção de etileno. Em muitas espécies a exposição dos frutos ao frio favorece a síntese de etileno, quando estes são transferidos para a temperatura ambiente, também a actividade enzimática da ACC sintetase aumenta rapidamente nos frutos quando da sua passagem para a temperatura ambiente. Em algumas variedades de pêras e maçãs têm-se mesmo utilizado a exposição a baixas temperaturas apenas com o objectivo de conseguir uma maturação mais homogénea e uma textura aceitável. Relativamente à ameixeira Prunus domestica L. ‘Rainha Claudia Verde’ existe pouca informação acerca da expressão dos genes que controlam a maturação, mais concretamente das enzimas ACC sintetase e ACC oxidase. Durante a maturação da ameixa ‘Rainha Claudia Verde’ observa-se um aumento na produção de etileno e na taxa de respiração, paralelamente a um decréscimo da acidez e da firmeza dos frutos. No entanto, contrariamente à maioria das espécies fruteiras, nesta variedade observa-se uma diminuição na taxa de produção de etileno quando os frutos, sujeitos à conservação pelo frio, são posteriormente retirados para a temperatura ambiente. Este decréscimo é tanto mais acentuado quanto maior for o período de exposição ao frio. Esta variedade é habitualmente conservada entre os 0-2 ºC e apresentando um período de comercialização de 2 semanas após a colheita. Pretendeu-se com este trabalho perceber que tipo de efeito existe relativamente à produção de etileno nesta variedade. Estudou-se a influência de duas temperaturas de conservação, (1 ºC e 7 ºC ± 1 ºC, na produção de etileno. Os frutos foram sujeitos a diferentes períodos de conservação frigorífica: 0, 2, 5, 8 e 14 dias, ao fim dos

  16. Annual review of energy and the environment. Volume 23

    Energy Technology Data Exchange (ETDEWEB)

    Socolow, R.H. [ed.] [Princeton Univ., NJ (United States); Anderson, D. [ed.] [Imperial College of Science, Technology, and Medicine, London (United Kingdom); Harte, J. [ed.] [Univ. of California, Berkeley, CA (United States)

    1998-12-31

    Thirteen papers are included in this volume. The titles and authors are: From Physics to Development Strategies by Jose Goldemberg; Rewards and Penalties of Monitoring the Earth by Charles D. Keeling; Science and Nonscience Concerning Human-Caused Climate Warming by J. D. Mahlman; Consumption of Materials in the United States, 1990--1995 by Grecia Matos and Lorie Wagner; Future Technologies for Energy-Efficient Iron and Steel Making by Jeroen de Beer, Ernst Worrell, and Kornelis Blok; The O{sub 2} Balance of the Atmosphere: A Tool for Studying the Fate of Fossil Fuel CO{sub 2} by Michael L. Bender, Mark Battle, and Ralph F. Keeling; Mexican Electric End-Use Efficiency: Experiences to Date by Rafael Friedmann and Claudia Sheinbaum; Drinking Water in Developing Countries by Ashok Gadgil; Engineering-Economic Studies of Energy Technologies to Reduce Greenhouse Gas Emissions: Opportunities and Challenges by Marilyn A. Brown, Mark D. Levine, Joseph P. Romm, Arthur H. Rosenfeld, and Jonathan G. Koomey; Climate Change Mitigation in the Energy and Forestry Sectors of Developing Countries by Jayant A. Sathaye and N. H. Ravindranath; Toward a Productive Divorce: Separating DOE Cleanups from Transition Assistance by M. Russell; Recycling Metals for the Environment by Iddo K. Wernick and Nickolas J. Themelis; and Environmentally Conscious Chemical Process Design by J. A. Cano-Ruiz and G. J. McRae.

  17. Breast cancer in Mongolia: an increasingly important health policy issue

    Directory of Open Access Journals (Sweden)

    Demchig D

    2017-01-01

    Full Text Available Delgermaa Demchig, Claudia Mello-Thoms, Patrick C Brennan Medical Image Optimization and Perception Group (MIOPeG, Faculty of Health Science, The University of Sydney, Sydney, NSW, Australia Abstract: Breast cancer is a leading cause of cancer-related death for women in both developed and developing countries. The incidence and mortality of breast cancer in Mongolia, while low compared with other counties, has been increasing on an annual basis. In addition, in Mongolia, approximately 90% of the patients are diagnosed at a late stage, resulting in high mortality, with the majority of individuals diagnosed with breast cancer dying within 5 years of diagnosis. Breast cancer screening plays an important role in reducing mortality in Western countries and has been adopted by a number of Asian countries; however, no such approach exists in Mongolia. In a country of limited resources, implementation of expensive health strategies such as screening requires effective allocations of resources and the identification of the most effective imaging methods. This requirement relies on recent accurate data; however, at this time, there is a paucity of information around breast cancer in Mongolia. Until data around features of the disease are available, effective strategies to diagnose breast cancer that recognize the economic climate in Mongolia cannot be implemented and the impact of breast cancer is likely to increase. Keywords: incidence, mortality, breast screening, Mongolia

  18. A Bayesian Framework for Multiple Trait Colo-calization from Summary Association Statistics.

    Science.gov (United States)

    Giambartolomei, Claudia; Zhenli Liu, Jimmy; Zhang, Wen; Hauberg, Mads; Shi, Huwenbo; Boocock, James; Pickrell, Joe; Jaffe, Andrew E; Pasaniuc, Bogdan; Roussos, Panos

    2018-03-19

    Most genetic variants implicated in complex diseases by genome-wide association studies (GWAS) are non-coding, making it challenging to understand the causative genes involved in disease. Integrating external information such as quantitative trait locus (QTL) mapping of molecular traits (e.g., expression, methylation) is a powerful approach to identify the subset of GWAS signals explained by regulatory effects. In particular, expression QTLs (eQTLs) help pinpoint the responsible gene among the GWAS regions that harbor many genes, while methylation QTLs (mQTLs) help identify the epigenetic mechanisms that impact gene expression which in turn affect disease risk. In this work we propose multiple-trait-coloc (moloc), a Bayesian statistical framework that integrates GWAS summary data with multiple molecular QTL data to identify regulatory effects at GWAS risk loci. We applied moloc to schizophrenia (SCZ) and eQTL/mQTL data derived from human brain tissue and identified 52 candidate genes that influence SCZ through methylation. Our method can be applied to any GWAS and relevant functional data to help prioritize disease associated genes. moloc is available for download as an R package (https://github.com/clagiamba/moloc). We also developed a web site to visualize the biological findings (icahn.mssm.edu/moloc). The browser allows searches by gene, methylation probe, and scenario of interest. claudia.giambartolomei@gmail.com. Supplementary data are available at Bioinformatics online.

  19. Smart Energy 2012. How smart is the way towards the turnaround in the energy policy; Smart Energy 2012. Wie smart ist der Weg zur Energiewende?

    Energy Technology Data Exchange (ETDEWEB)

    Grossmann, Uwe; Kunold, Ingo (eds.)

    2012-07-01

    The contribution under consideration contains fifteen contributions of well-known authors from commercial enterprises, public institutions and universities on smart energy: (1) Smart grids, but surely (Claudia Eckert); (2) Requirements concerning the further development of data protection and data security as part of the technological change (Reinhold Harnisch); (3) Standardization in the smart grid (Harald Orlamuender); (4) IEC 61850 - The standard for energy automation (Georg Harnischmacher); (5) Smart City, the intelligent grid in the city (Michael Laskowski); (6) IKT is a basis for a real smart power distribution system (Justus Bross); (7) Power transparency and optimized building optimization by means of a holistic automation concepts (Joerg Wollert); (8) Distributed architecture for a balancing aggregation of consumption and generation of power in private households (Kilian Hemmeboehle); (9) Development of an e-energy market place and first experiences from the field test in the E-DeMa project (Bernd Werner); (10) Smart metering rollout pilot ''30,000er'' (Axel Lauterkorn); (11) Experiences with the connexion and communication to smart meters in the project eTelligence (Guenter Pistoor); (12) Smart Phoenix - Intelligent energy networks in Dortmund (Roland Brueggemann); (13) Smart planning (C. Engels); Intelligent house control by means of smart metering (Sabine Wieland); (14) Dynamic billing of energy and value-added service in the networked home (Frank C. Bormann).

  20. Defective DNA repair mechanisms in prostate cancer: impact of olaparib

    Directory of Open Access Journals (Sweden)

    De Felice F

    2017-03-01

    Full Text Available Francesca De Felice,1 Vincenzo Tombolini,1 Francesco Marampon,2 Angela Musella,3 Claudia Marchetti3 1Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, 2Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L’Aquila, L’Aquila, 3Department of Gynecological and Obstetrical Sciences and Urological Sciences, “Sapienza” University of Rome, Rome, Italy Abstract: The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1 and breast cancer 2 gene (BRCA2 mutations are implicated in the highest risk of prostate cancer (PC predisposition and aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP proteins play a key role in DNA repair mechanisms and represent a valid target for new therapies. Olaparib is an oral PARP inhibitor that blocks DNA repair pathway and coupled with BRCA mutated-disease results in tumor cell death. In phase II clinical trials, including patients with advanced castration-resistant PC, olaparib seems to be efficacious and well tolerated. Waiting for randomized phase III trials, olaparib should be considered as a promising treatment option for PC. Keywords: prostate cancer, metastatic disease, castration resistant, BRCA, DNA-repair, PARP, olaparib

  1. 'Mini' total body irradiation and allogeneic bone marrow transplantation

    International Nuclear Information System (INIS)

    Gocheva, L.; Sergieva, K.; Koleva, I.; Avramova, V.; Vassileva, V.; Georgieva, S.; Sultanov, B.

    2006-01-01

    Full text: The total body irradiation (TBI) combined with intensive chemotherapy plays an important role in the preparation of patients for bone marrow transplantation (BMT). The first autologous BMT in Bulgaria was performed in 1997 in the Specialized Pediatric Hospital for Active Treatment (SPHAT) of oncohematological diseases. The first TBI, followed by allogeneic BMT, was carried out in 2002 in the 'Queen Giovanna' University Hospital, after which its routine application as a basic form of large field radiotherapy and a main stage of the conditioning regimen for BMT was started. Fourteen allogeneic BMTs including TBI as a basic conditioning regimen have been performed till May 2006. The objective of the present report is to present the first clinical observations in the Bulgarian oncological practice on 'mini' TBI followed by allogeneic blood stem cell transplantation. During the period October 2005 - May 2006, 'mini' TBI followed by allogeneic BMT was carried out for two patients of the age 43 and 50 years. The diagnosis of both patients was acute non-lymphoblastic leukemia, in the remission stage, after one relapse, respectively. Intensive preceding chemotherapy was applied for both patients. A conditioning regimen was applied including the fludarabine purine analogue (3 x 30 mg/m 2 ) and 200 cGy TBI. It was followed by transplantation of allogeneic cell concentrate containing 2.5 x10 6 /kg CD34+ and 4.0 x10 6 /kg CD34+ blood stem cells of partially compatible family donors (a sister and a son), which were tolerable for the patients without complications. Cyclosporine and mycophelonate mofetile were applied as post-transplantation treatment. Active antibiotic, antiviral, symptomatic and substituting therapy, as well as GvHD prophylaxis was applied for both patients. Good clinical tolerance was recorded for the applied low dose conditioning regimen. The patients were discharged within 30 days in good general condition and stable draft action, with

  2. RICKETS AT THE MEDICI COURT OF FLORENCE: THE CASE OF DON FILIPPINO (1577-1582).

    Science.gov (United States)

    Castagna, Maura; Giuffra, Valentina; Fattori, Silvia; Vitiello, Angelica; Caramella, Davide; Giustini, Davide; Fornaciari, Gino

    2014-01-01

    Among the children found in the crypt of the Grand Duke Giangastone in S. Lorenzo Basilica (Florence), the skeletal remains of a 5-year-old child still wearing his fine high social status clothing were recovered. This child of the Medici family was identified as Don Filippino (1577-1582), son of the Grand Duke Francesco I (1541-1587) and Giovanna from Austria (1547 - 1578). The prince showed several pathological deformities of the cranial and post-cranial skeleton, including enlargement of the cranium, thinning of the cranial vault bones (craniotabes), platybasia and marked bending of femora, tibiae and fibulae. Differential diagnosis suggests that Don Filippino was affected by rickets. The occurrence of this metabolic disease related to vitamin D deficiency in a Renaissance high social class individual can be explained by the practice of very prolonged breast-feeding, up until two years of age. Maternal milk contains insufficient vitamin D ratios and retarded weaning severely exposes children to a higher risk of developing rickets, especially if dietary habits are combined with inadequate exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal remains of Don Filippino are compatible with a diagnosis of rickets, caused by the custom of prolonged breast-feeding associated with inadequate sunlight exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal

  3. Bevacizumab in the treatment of NSCLC: patient selection and perspectives

    Directory of Open Access Journals (Sweden)

    Russo AE

    2017-12-01

    Full Text Available Alessia E Russo,1 Domenico Priolo,1 Giovanna Antonelli,1 Massimo Libra,2 James A McCubrey,3 Francesco Ferraù1 1Medical Oncology Department, San Vincenzo Hospital, Taormina (Messina, Italy; 2Laboratory of Translational Oncology & Functional Genomics, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; 3Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA Abstract: Non-small-cell lung cancer (NSCLC represents about 85% of all lung cancers, and more than half of NSCLCs are diagnosed at an advanced stage. Chemotherapy has reached a plateau in the overall survival curve of about 10 months. Therefore, in last decade novel targeted approaches have been developed to extend survival of these patients, including antiangiogenic treatment. Vascular endothelial growth factor (VEGF signaling pathway plays a dominant role in stimulating angiogenesis, which is the main process promoting tumor growth and metastasis. Bevacizumab (bev; Avastin® is a recombinant humanized monoclonal antibody that neutralizes VEGF’s biologic activity through a steric blocking of its binding with VEGF receptor. Currently, bev is the only antiangiogenic agent approved for the first-line treatment of advanced or recurrent nonsquamous NSCLC in “bev-eligible” patients. The ineligibility to receive bev is related to its toxicity. In the pivotal trials of bev in NSCLC, fatal bleeding events including pulmonary hemorrhage were observed with rates higher in the chemotherapy-plus-bev group. Therefore, in order to reduce the incidence of severe pulmonary hemorrhage, numerous exclusion criteria have been characteristically applied for bev such as central tumor localization or tumor cavitation, use of anticoagulant therapy, presence of brain metastases, age of patients (elderly. Subsequent studies designed to evaluate the safety of bev have demonstrated that this agent is safe and

  4. Romanian Association of Balneology Conference – 2015, 28 – 31 May, Băile Tuşnad

    Directory of Open Access Journals (Sweden)

    MUNTEANU Constantin

    2015-05-01

    Full Text Available 1.\tProf. Onose G, MD, PhD, MSc, Univ. Assist. Haras MA, MD, PhD, Prof. Sinescu CJ, MD, PhD1,2, Univ. Assist. Daia CO, MD, PhD1,2, RDI Assist. Andone I, MD, Postgrad2, Onose VL, MD,3, Assist. Prof. Capisizu A, MD, PhD1,4, Prof. Grigorean VT, MD, PhD1,2, Assoc. Prof. Ciobotaru C, MD, PhD5,6, Sandu AM, MD, Postgrad.2, Assist. Prof. Blendea CD, MD, PhD7, 8 - BASIC WELLNESS FEATURES AND SOME RELATED ACTIONS, PROPENSIVE INCLUDING FOR ACTIVE AND HEALTHY AGEING - 2.\tOlga SURDU, T.V. SURDU, Monica SURDU - STATE OF ART of balneotherapy/thermalisme in Romania 3.\tIliuta Maria Alexandra - THE IMPORTANCE OF NUTRITION IN HEALTH PROGRAMS 4.\tDr. Dogaru Gabriela - THERAPEUTIC EFFECTS OF MINERAL WATERS IN RENAL DISEASES 5.\tVeryho N.S. - THERAPEUTIC EFFECT OF MINERAL WATER WITH DIFFERENT CONCENTRATIONS OF HUMIC ACIDS IN EXPERIMENTAL HEPATITIS INDUCED BY ACETAMINOPHEN 6.\tIoana Marian - SPA SEEN AS AN EXTENSION OF A HEALTH RESORT - A NECESSARY CONDITION FOR INTEGRATING ROMANIA IN THE LIST OF GLOBAL WELLNESS TOURISM DESTINATIONS 7.\tBilha Neli-Claudia, Bilha Stefan - THE BALNEARY TREATMENT COURSE – A BREATH OF LIFE 8.\tBilha Neli-Claudia, Bilha Stefan - WICH SALT MINE DO YOU RECOMMEND FOR SPELEOTHERAPY? Interdisciplinary project proposal. 9.\tGáspár Boróka, Gabriela Dogaru - BALNEOTHERAPY IN THE BOGHIŞ RESORT 10.\tDr. Luminita Aurelia Pasca - REHABILITATION OF ELDERLY PATIENTS WITH CARDIOVASCULAR DISEASE 11.\tDr. Luminita Aurelia Pasca, Dr. Valer Donca - GEROVITAL – PROPHYLAXIS OF AGING AND GERIATRIC TREATMENT 12.\tAndronache Cristina - IMPORTANCE OF REHABILITATION TREATMENT IN HEMOPHILIC ARTHROPATHY – A CASE REPORT 13.\tDr. Motricala Marieta, Molnar Akos - BALNEOTHERAPY IN BAILE TUSNAD 14.\tIoana Pop, Bianca Pop - MEDICAL REHABILITATION IN NEUROPATHIC PAIN 15.\tAmalia Salca¹, Nicoleta Stoica1, Gabriela Dogaru¹,² - BALNEOTHERAPY IN GONARTHROSIS 16.\tAlexandru Bogdan-Cătălin, Toşa Edith-Éva - USING PULSED SHORT WAVE (DIAPULSE COMPLEMENTARY TO

  5. Teaching Library: Vermittlung von Informationskompetenz an medizinischen Bibliotheken

    Directory of Open Access Journals (Sweden)

    Bauer, Bruno

    2014-08-01

    Full Text Available [english] The focus of the current issue 1-2/2014 of GMS Medizin – Bibliothek – Information is on “Teaching Library: information literacy instruction at medical libraries”. The authors in this issue are Marina Betker & Annette Kustos (Literature research training in health sciences in a new academic library – straight through and strategic planning: the concept of the “hsg Bochum”, Simone Waldboth (Integration of e-learning in the lecture “Information Literacy” at the Provincial College for Health-Care Professions „Claudiana“, Michaele Adam & Jens Mittelbach (Shaping the Future at the SLUB Dresden with Information Literacy in the Research Cycle, Gregor Steinrisser (Sucessfully failing – Fiction and Friction of a teaching library in university and clinical daily routine, Melanie Kintzel & Norbert Sunderbrink (Information literacy classes at the Medical Library of the University Medical Center Hamburg-Eppendorf, Markus Schmiel (The teaching and learning concept of the Library of the Hannover Medical School, Jutta Matrisciano & Martina Semmler-Schmetz (Teaching Library – Realization of a concept with many facets at the Library for the Medical Faculty of Mannheim, Karin Cepicka („Teaching Library“ at the Library oft the Medical University Vienna, Helmut Dollfuß (Library user education for the new curriculum at the Medical University Vienna, Manuela Rohrmoser & Irene Schachl (The cooperations of teaching librarians at Vienna University Library und Claudia Hausberger & David Frank (Curriculum reform – a work report from the Library of the University of Veterinary Medicine Vienna.

  6. Rifaximin in the treatment of hepatic encephalopathy

    Directory of Open Access Journals (Sweden)

    Iadevaia MD

    2011-12-01

    Full Text Available Maddalena Diana Iadevaia, Anna Del Prete, Claudia Cesaro, Laura Gaeta, Claudio Zulli, Carmelina LoguercioDepartment of Internistica Clinica e Sperimentale, F Magrassi e A Lanzara, Hepatogastroenterology Unit, Second University of Naples, Naples, ItalyAbstract: Hepatic encephalopathy is a challenging complication in patients with advanced liver disease. It can be defined as a neuropsychiatric syndrome caused by portosystemic venous shunting, ranging from minimal to overt hepatic encephalopathy or coma. Its pathophysiology is still unclear, although increased levels of ammonia play a key role. Diagnosis of hepatic encephalopathy is currently based on specific tests evaluating the neuropsychiatric state of patients and their quality of life; the severity of hepatic encephalopathy is measured by the West Haven criteria. Treatment of hepatic encephalopathy consists of pharmacological and corrective measures, as well as nutritional interventions. Rifaximin received approval for the treatment of hepatic encephalopathy in 2010 because of its few side effects and pharmacological benefits. The aim of this work is to review the use and efficacy of rifaximin both in acute and long-term management of hepatic encephalopathy. Treatment of overt hepatic encephalopathy involves management of the acute episode as well as maintenance of remission in those patients who have previously experienced an episode, in order to improve their quality of life. The positive effect of rifaximin in reducing health care costs is also discussed.Keywords: acute hepatic encephalopathy, recurrent hepatic encephalopathy, rifaximin, lactulose, cost, health-related quality of life

  7. Living in the past: phylogeography and population histories of Indo-Pacific wrasses (genus Halichoeres in shallow lagoons versus outer reef slopes.

    Directory of Open Access Journals (Sweden)

    William B Ludt

    Full Text Available Sea level fluctuations during glacial cycles affect the distribution of shallow marine biota, exposing the continental shelf on a global scale, and displacing coral reef habitat to steep slopes on oceanic islands. In these circumstances we expect that species inhabiting lagoons should show shallow genetic architecture relative to species inhabiting more stable outer reefs. Here we test this expectation on an ocean-basin scale with four wrasses (genus Halichoeres: H. claudia (N = 194, with ocean-wide distribution and H. ornatissimus (N = 346, a Hawaiian endemic inhabit seaward reef slopes, whereas H. trimaculatus (N = 239 and H. margaritaceus (N = 118 inhabit lagoons and shallow habitats throughout the Pacific. Two mitochondrial markers (cytochrome oxidase I and control region were sequenced to resolve population structure and history of each species. Haplotype and nucleotide diversity were similar among all four species. The outer reef species showed significantly less population structure, consistent with longer pelagic larval durations. Mismatch distributions and significant negative Fu's F values indicate Pleistocene population expansion for all species, and (contrary to expectations shallower histories in the outer slope species. We conclude that lagoonal wrasses may persist through glacial habitat disruptions, but are restricted to refugia during lower sea level stands. In contrast, outer reef slope species have homogeneous and well-connected populations through their entire ranges regardless of sea level fluctuations. These findings contradict the hypothesis that shallow species are less genetically diverse as a consequence of glacial cycles.

  8. Drug abuse in athletes

    Directory of Open Access Journals (Sweden)

    Reardon CL

    2014-08-01

    Full Text Available Claudia L Reardon, Shane Creado Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Abstract: Drug abuse occurs in all sports and at most levels of competition. Athletic life may lead to drug abuse for a number of reasons, including for performance enhancement, to self-treat otherwise untreated mental illness, and to deal with stressors, such as pressure to perform, injuries, physical pain, and retirement from sport. This review examines the history of doping in athletes, the effects of different classes of substances used for doping, side effects of doping, the role of anti-doping organizations, and treatment of affected athletes. Doping goes back to ancient times, prior to the development of organized sports. Performance-enhancing drugs have continued to evolve, with “advances” in doping strategies driven by improved drug testing detection methods and advances in scientific research that can lead to the discovery and use of substances that may later be banned. Many sports organizations have come to ban the use of performance-enhancing drugs and have very strict consequences for people caught using them. There is variable evidence for the performance-enhancing effects and side effects of the various substances that are used for doping. Drug abuse in athletes should be addressed with preventive measures, education, motivational interviewing, and, when indicated, pharmacologic interventions. Keywords: doping, athletes, steroids, drug abuse, mental illness

  9. The National Acupuncture Detoxification Association protocol, auricular acupuncture to support patients with substance abuse and behavioral health disorders: current perspectives

    Directory of Open Access Journals (Sweden)

    Stuyt EB

    2016-12-01

    Full Text Available Elizabeth B Stuyt,1 Claudia A Voyles2 1Department of Psychiatry, University of Colorado Health Sciences Center, Pueblo, CO, 2Department of Clinical Studies, AOMA Graduate School of Integrative Medicine, Austin, TX, USA Abstract: The National Acupuncture Detoxification Association (NADA-standardized 3- to 5-point ear acupuncture protocol, born of a community-minded response to turbulent times not unlike today, has evolved into the most widely implemented acupuncture-assisted protocol, not only for substance abuse, but also for broad behavioral health applications. This evolution happened despite inconsistent research support. This review highlights the history of the protocol and the research that followed its development. Promising, early randomized-controlled trials were followed by a mixed field of positive and negative studies that may serve as a whole to prove that NADA, despite its apparent simplicity, is neither a reductive nor an independent treatment, and the need to refine the research approaches. Particularly focusing on the last decade and its array of trials that elucidate aspects of NADA application and effects, the authors recommend that, going forward, research continues to explore the comparison of the NADA protocol added to accepted treatments to those treatments alone, recognizing that it is not a stand-alone procedure but a psychosocial intervention that affects the whole person and can augment outcomes from other treatment modalities. Keywords: National Acupuncture Detoxification Association (NADA, ear acupuncture, acudetox, addiction, mental health, trauma

  10. Historical evolution of the concept of anorexia nervosa and relationships with orthorexia nervosa, autism, and obsessive-compulsive spectrum

    Directory of Open Access Journals (Sweden)

    Dell'Osso L

    2016-07-01

    Full Text Available Liliana Dell’Osso,1 Marianna Abelli,1 Barbara Carpita,1 Stefano Pini,1 Giovanni Castellini,2 Claudia Carmassi,1 Valdo Ricca2 1Psychiatry Section, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 2Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA, University of Florence, Florence, Italy Abstract: Eating disorders have been defined as “characterized by persistence disturbance of eating or eating-related behavior that results in the altered consumption or absorption of food and that significantly impairs health or psychosocial functioning”. The psychopathology of eating disorders changed across time under the influence of environmental factors, determining the emergence of new phenotypes. Some of these conditions are still under investigation and are not clearly identified as independent diagnostic entities. In this review, the historic evolution of the eating disorder concept up to the recent Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, has been evaluated. We also examined literature supporting the inclusion of new emergent eating behaviors within the eating disorder spectrum, and their relationship with anorexia, autism, and obsessive–compulsive disorder. In particular, we focused on what is known about the symptoms, epidemiology, assessment, and diagnostic boundaries of a new problematic eating pattern called orthorexia nervosa that could be accepted as a new psychological syndrome, as emphasized by an increasing number of scientific articles in the last few years. Keywords: anorexia nervosa, autism spectrum disorders, eating disorders spectrum, obsessive–compulsive spectrum, orthorexia nervosa, DSM-5

  11. Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation

    Directory of Open Access Journals (Sweden)

    Mariagrazia Di Marco

    2009-12-01

    Full Text Available Mariagrazia Di Marco1, Shaharum Shamsuddin2, Khairunisak Abdul Razak3, Azlan Abdul Aziz4, Corinne Devaux1, Elsa Borghi1, Laurent Levy1, Claudia Sadun51Nanobiotix, Paris, France; 2School of Health Sciences, Health Campus Universiti Sains Malaysia, Kelantan, Malaysia; 3School of Materials and Mineral Resources Engineering, Engineering Campus, 4School of Physics, Universiti Sains Malaysia, Penang, Malaysia; 5Department of Chemistry, Sapienza, University of Rome, Rome, ItalyAbstract: The latest development of protein engineering allows the production of proteins having desired properties and large potential markets, but the clinical advances of therapeutical proteins are still limited by their fragility. Nanotechnology could provide optimal vectors able to protect from degradation therapeutical biomolecules such as proteins, enzymes or specific polypeptides. On the other hand, some proteins can be also used as active ligands to help nanoparticles loaded with chemotherapeutic or other drugs to reach particular sites in the body. The aim of this review is to provide an overall picture of the general aspects of the most successful approaches used to combine proteins with nanosystems. This combination is mainly achieved by absorption, bioconjugation and encapsulation. Interactions of nanoparticles with biomolecules and caveats related to protein denaturation are also pointed out. A clear understanding of nanoparticle-protein interactions could make possible the design of precise and versatile hybrid nanosystems. This could further allow control of their pharmacokinetics as well as activity, and safety.Keywords: nanoparticles, drug delivery, proteins, polypeptides, absorption, bioconjugation, encapsulation

  12. Golimumab in unresponsive ulcerative colitis

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    Lippert E

    2014-05-01

    Full Text Available Elisabeth Lippert, Martina Müller, Claudia Ott University Hospital Regensburg, Department of Internal Medicine I, Regensburg, Germany Abstract: Ulcerative colitis (UC is a chronic inflammation mainly affecting the colon mucosa. It predominantly occurs in younger patients. Until recently, the main goals in the treatment of UC were to temper the symptoms, such as diarrhea, pain, and weight loss, by using mesalazine and steroids. With newer medications, such as immunomodulators (thiopurines and the biologics providing blockade of tumor necrosis factor (TNF, the goals of the therapy in UC have changed to long-term remission and mucosal healing. The first available anti-TNF therapy in UC included infusion therapy with infliximab every few weeks. In 2012, subcutaneously administered adalimumab gained approval for the treatment of UC in Germany. In patients with a mild disease, therapy with mesalazine, orally or topically, can be sufficient. In patients with moderate to severe disease, therapy with azathioprine or anti-TNF is often required to reach disease control; however, this is only efficient in about two-thirds of patients. Some patients either show no response or a lost response while on treatment. So, further medical options are warranted in the treatment of UC. With golimumab, a new approach in the treatment of mild to moderate UC recently became available in Germany and is a promising new option in the therapy regimen for patients with UC. Keywords: anti-TNF, biological therapy, inflammatory bowel disease

  13. Lift the quilt in case of atrial fibrillation and disc prolapse

    Directory of Open Access Journals (Sweden)

    Bastovansky A

    2012-06-01

    Full Text Available Adam Bastovansky,1 Kathrin Ziegler,2 Claudia Stöllberger,2 Josef Finsterer31Department of Radiology, 2Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria; 3Danube University Krems, Krems, AustriaBackground: Peripheral embolism to the lower extremities may mimic disc prolapse with severe consequences.Case report:  A 71-year-old male with a history of chronic alcoholism developed low back pain radiating to both lower extremities in a nonradicular distribution and bilateral dysesthesias of the distal lower legs after lifting a heavy weight. Given that magnetic resonance imaging (MRI of the lumbar spine showed disc herniation in L3/4 and L4/5, he was scheduled for laminectomy but was unable to undergo surgery due to thrombocytopenia. After transfer to another hospital, persistence of symptoms and signs, absent pulses on the distal lower legs, and rhabdomyolysis with temporary renal insufficiency, peripheral embolism with compartment syndrome was suspected. Magnetic resonance angiography revealed occlusion of the right superficial femoral artery and long high-grade stenosis of the left superficial and profound femoral arteries and distal arteries. He successfully underwent embolectomy and fasciotomy.Conclusions: If lumbar pain is not radicular, peripheral pulses are minimally palpable, and distal limbs are cold and show livid decolorization, peripheral embolism is much more likely than disc herniation, particularly if the patient's history is positive for atrial fibrillation. MRI of the lumbar spine must be interpreted in conjunction with clinical presentation.Keywords: embolism, compartment syndrome, neurosurgery, embolectomy, fasciotomy, rhabdomyolysis

  14. PREFACE: Young Researcher Meeting, Trieste 2013

    Science.gov (United States)

    Agostini, F.; Antolini, C.; Aversa, R.; Cattani, G.; Martinelli, M.; Mazzaferro, L.; Migliaccio, M.; Paci, F.; Pietrobon, D.; Ricci Pacifici, D.; Stellato, F.; Veneziani, M.

    2013-12-01

    YRM logo The Young Researcher Meeting (www.yrmr.it) has been a rapidly growing event for the last few years. Together with other initiatives which have emerged in several research areas, the young researcher meeting marks the awareness and the desire of PhD students, postdoctoral fellows and young researchers to play a major role in scientific progress. Devoted to the discussion and the interchange of new developments and ideas in physics, the meeting is primarily aimed at graduate students and postdoctoral researchers, who are encouraged to present their work in an informal atmosphere. One of the main purposes of the conference is to create an international network of young researchers, both experimentalists and theorists, and fruitful collaborations across the different branches of physics. Born in Rome in 2009, after three editions that strengthened it, the Young Researcher Meeting 2013 was held in Trieste. Propelled by the past success, the fourth meeting was a two-day conference on 3-4June. It was sponsored by the International School for Advanced Studies - SISSA - and the University of Padova, thus acquiring an even further international drive. In this volume, we collect some of the contributions that were presented at the conference. They cover topics in astrophysics and cosmology, particle and theoretical physics, soft and condensed matter, biophysics and medical physics. YRM Organising and Editorial Committee Fabio Agostini (fabio.agostini@roma2.infn.it) Dipartimento di Fisica, Università di Roma 'Tor Vergata' Via della Ricerca Scientifica 1, 00133 Roma, Italy Claudia Antolini (claudia.antolini@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Via Bonomea 265, 34136 Trieste, Italy Rossella Aversa (raversa@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Via Bonomea 265, 34136 Trieste, Italy Giordano Cattani (giordano.cattani@gmail.com) Matteo Martinelli (mmartin@sissa.it) SISSA - Scuola Internazionale Superiore di

  15. Apresentação Workshop Baía de Guanabara

    Directory of Open Access Journals (Sweden)

    Claudia Gutteres Vilela

    2003-01-01

    Full Text Available Ano 2003 Volume 26 - Workshop Baía de Guanabara Editor: Ismar de Souza Carvalho Coordenadora: Claudia Gutteres Vilela: Apresentação ISSN: 0101-9759 É com grande prazer que participo da edição do Anuário de 2003 do Instituto de Geociências, que inclui os trabalhos apresentados no Workshop Baía, realizado nos dias 12 e 13 de novembro de 2002, nesta instituição. O sucesso desse evento deve-se em grande parte aos trabalhos, apresentados sob a forma de palestras em mesas redondas ou painéis, por pesquisadores consagrados no Brasil e no exterior. O conteúdo dos trabalhos possui uma abrangência que se estende desde a Geologia até a Biologia, passando pela Oceanografia e Geografia, sempre com o objetivo comum de reunir dados sobre a Baía de Guanabara visando o diagnóstico ambiental. O Workshop Baía congregou diversas linhas de pesquisa desenvolvidas na Baía de Guanabara e regiões adjacentes, procurando uma integração das mesmas. Deste modo alguns trabalhos caracterizaram, em um contexto mais geral, a evolução do nível do mar na região sudeste durante o Holoceno, bem como apresentaram a neotectônica da região. Geoquímica orgânica de hidrocarbonetos e de metais pesados, sedimentologia e hidrogeologia integraram-se à distribuição de microorganismos nos sedimentos e na água, analisando diversas respostas a diferentes graus de poluição em regiões distintas. Um zoneamento ambiental ofereceu uma visão dinâmica das condições naturais e sociais do conjunto da Baía de Guanabara. A importância do workshop deve-se à busca de uma integração maior dos trabalhos acadêmicos para aplicação à gestão do desenvolvimento sustentável da Baía de Guanabara e seu entorno, que abriga a cidade do Rio de Janeiro e se constitui em uma das regiões com maior índice demográfico do Brasil. Seu impacto pode se avaliado pela presença de representantes de órgãos públicos como a SERLA, a Prefeitura de Niterói e ONGs ligadas a

  16. Illness denial questionnaire for patients and caregivers

    Directory of Open Access Journals (Sweden)

    Rossi Ferrario S

    2017-03-01

    Full Text Available Silvia Rossi Ferrario,1 Ines Giorgi,2 Paola Baiardi,3 Laura Giuntoli,4 Gianluigi Balestroni,1 Paola Cerutti,1 Marina Manera,2 Paola Gabanelli,2 Valentina Solara,5 Roberta Fornara,6 Michela Luisetti,1 Pierangela Omarini,1 Giovanna Omarini,1 Giulio Vidotto4 1Psychology Unit, Istituti Clinici Scientifici Maugeri SpA SB, Veruno, NO, Italy; 2Psychology Unit, 3Scientific Direction, Istituti Clinici Scientifici Maugeri SpA SB, Pavia, Italy; 4Department of General Psychology, University of Padova, Padova, Italy; 5Department of Neurology, ALS Centre, “Maggiore della Carita`” University Hospital, Novara, Italy; 6Psychology Unit, SS Trinità Hospital, Borgomanero, NO, Italy Purpose: Interest in assessing denial is still present, despite the criticisms concerning its definition and measurement. We tried to develop a questionnaire (Illness Denial Questionnaire, IDQ assessing patients’ and caregivers’ denial in relation to their illness/disturbance. Patients and methods: After a preliminary study, a final version of 24 dichotomous items (true/false was selected. We hypothesized a theoretical model with three dimensions: denial of negative emotions, resistance to change, and conscious avoidance, the first two composing the actual Denial and the last representing an independent component of the illness denial behavior. The IDQ was administered to 400 subjects (219 patients and 181 caregivers together with the Anxiety–Depression Questionnaire – Reduced form (AD-R, in order to assess concurrent validity. Confirmatory factor analysis (CFA, internal consistency indices (Cronbach’s α and McDonald’s ω, and test–retest analysis were performed. Results: CFA and internal consistency indices (Cronbach’s α: 0.87–0.96 indicated a clear and meaningful three-factor structure of IDQ, for both patients and caregivers. Further analyses showed good concurrent validity, with Denial and its subscale negatively associated with anxiety and depression and

  17. Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases

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    Iudici M

    2017-02-01

    Full Text Available Michele Iudici, Rosaria Irace, Antonella Riccardi, Giovanna Cuomo, Serena Vettori, Gabriele Valentini Rheumatology Section, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy Introduction/objectives: To prospectively assess the quality of life (QoL of patients affected by undifferentiated connective tissue diseases (UCTDs and to identify factors associated with changes over time.Patients and methods: A total of 46 consecutive UCTD patients completed the Short-Form 36 (SF-36 questionnaire at presentation and then yearly. At each 6-month visit, all patients underwent a detailed history taking and a laboratory and physical assessment, in order to follow the evolution of the disease over time and to assess the the co-existence of fibromyalgia.Results: At presentation, scores lower than the average of the general population were detected in 34 (74% and 41 (89% patients in the physical and mental domains, respectively. No difference between patients with and without Raynaud’s phenomenon was detected. Fibromyalgia was the only independent variable associated with an impaired physical component summary score (p = 0.0009. No patient feature was found to be associated with the basal mental component summary score. During 24 months of follow-up, a significant improvement (ie, a change ≥5 from baseline in physical component summary and mental component summary scores was observed in 14 (33.3% and 20 (43.4% patients, respectively. Patients who significantly improved in the physical domain more frequently had a history of glucocorticoids intake (p < 0.001, while those who improved in the mental component more frequently had a history of either glucocorticoids (p = 0.043 or immunosuppressors (p = 0.037 intake during follow-up.Conclusion: UCTD patients perceive a worse QoL, regardless of Raynaud’s phenomenon Fibromyalgia is one of the major contributors of physical QoL, whereas no factor influencing

  18. New strategies to ensure good patient–physician communication when treating adolescents and young adults with cancer: the proposed model of the Milan Youth Project

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    Magni MC

    2015-08-01

    Full Text Available Maria Chiara Magni,1 Laura Veneroni,1 Carlo Alfredo Clerici,2 Tullio Proserpio,3 Giovanna Sironi,1 Michela Casanova,1 Stefano Chiaravalli,1 Maura Massimino,1 Andrea Ferrari1 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; 2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 3Pastoral Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Abstract: Adolescence is a particularly complex time of life, entailing physiological, psychological, and social changes that further the individual's cognitive, emotional, and social growth. Being diagnosed with cancer at this time can have important consequences on an individual's emotional and physical development, and adolescent and young adult cancer patients have particular medical and psychosocial needs. Patient–physician communications are important in any clinical relationship, but fundamental in the oncological sphere because their quality can affect the patient–physician relationship, the therapeutic alliance, and patient compliance. A major challenge when dealing with adolescent and young adult patients lies in striking the right balance between their need and right to understand their disease, treatment, and prognosis, and the need for them to remain hopeful and to protect their emotional sensitivity. We herein describe the activities of the Youth Project of the Istituto Nazionale Tumori in Milan, Italy in order to share a possible model of interaction with these special patients and the tactics our group has identified to help them communicate and share their thoughts. This model implies not only the involvement of a multidisciplinary team, including psychologists and spirituality experts, but also the constitution of dedicated creative activities to give patients the opportunity to express feelings they would otherwise never feel at ease putting into words. These efforts seek the goal to minimize the potentially

  19. [Challenges in the context of medical care during a naval research expedition. A case report].

    Science.gov (United States)

    Schröter, C; Schwarz-Schampera, U; Mommsen, P; Krettek, C

    2014-05-01

    Exploration for natural resources in the seabed of the Indian Ocean was undertaken by the German government institution of earth sciences and resources ("Bundesanstalt für Geowissenschaften und Rohstoffe", BGR) in November 2012. To provide for the medical safety of crew and scientists, a cooperation between the BGR and the trauma department of the Hannover Medical School was established. Research by physicians accompanying the naval expedition revealed that medical consultations mainly occur because of respiratory infections, abdominal discomfort, genitourinary discomfort and seasickness, with the rate of traumas being between 31% and 41%. Di Giovanna et al. stated that 97% of all emergencies on cruise ships are not critical and only 3% need an immediate emergency medical intervention. Consultations were already performed on the mainland prior to departure and included minor traumas due to non-appropriate footwear, otitis and respiratory infections. Seasickness was the main reason for consultation during the first days at sea. Strong seas resulted in some bruises. Minor injuries and foreign body injuries to the hands and feet also required consultation. First-degree sunburns resulted from exposure to the sun, while air-conditioning caused rhinosinusitis and conjunctivitis. A special consultation was a buccal splitting of tooth 36. An immediate emergency medical intervention was not necessary due to the relative low level of pain for the patient; however, due to the risk of further damage caused by nocturnal bruxism, a protective splint was formed using a small syringe. Other reasons for consultation were similar to those reported in the general literature. Medical activities at exotic locations may create the vision of a holiday character at first; however, intensive planning and preparation are needed. We recommend contacting police, customs, the federal institute for drugs and medical devices as well as the labour inspectorate, preferably in both the originating

  20. Revista de Libros. Books Review

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    Camarero, Hernán

    2012-09-01

    Full Text Available ARICÓ, José M.; Marx y América Latina, Fondo de Cultura Económica, Buenos Aires, 2010, 304 pp. COSSE, Isabella; Pareja, sexualidad y familia en los años sesenta, Buenos Aires, Siglo XXI, 2010, 257 páginas. BASUALDO, Eduardo; Sistema político y modelo de acumulación. Tres ensayos sobre la argentina actual, Cara o Ceca, Buenos Aires, 2011, 220 p. POJASI, Alejandro Ubaldo; Cabildos y Revoluciones. 1809 Chuquisaca y La Paz 1810. Buenos Aires y Salta del Tucumán, Hanne Editorial, Salta, 2010, 200 pp. KAPLÁN, Marta, Judíos en Formosa. Una historia centenaria (1909-2009, Subsecretaría de Cultura de la Provincia de Formosa, Formosa, Colección Cultura Nº 8, 2009, 396 pp. TORRE, Claudia, El otro desierto de la nación argentina. Antología de narrativa expedicionaria, Editorial Universidad de Quilmes, Bernal, 2011, pp. 387. MAN, Ronen; Rosario en el Centenario. Movilizaciones sociales, conflictividad, ciudadanía política y opinión pública en torno a 1910, Rosario, Quinta Pata y Camino Ediciones, Año 2011, 118 pp. MATA, Sara y PALERMO, Zulma (comps.; Travesía discursiva: representaciones identitarias en Salta (siglos XVIII-XXI, Prohistoria, Rosario, 2011, 207 pp. TARRAGÓ, Griselda; De la orilla del mar a la vera del río: migrantes y comerciantes genoveses en el Plata y el Paraná (1820-1860, Prohistoria, Rosario, 2011, pp. 240, ISBN 978-987- 1304-65-3

  1. A clinical and radiological objective tumor response with somatostatin analogs (SSA in well-differentiated neuroendocrine metastatic tumor of the ileum: a case report

    Directory of Open Access Journals (Sweden)

    De Divitiis C

    2015-03-01

    Full Text Available Chiara De Divitiis,1 Claudia von Arx,2 Roberto Carbone,3 Fabiana Tatangelo,4 Elena di Girolamo,5 Giovanni Maria Romano,1 Alessandro Ottaiano,1 Elisabetta de Lutio di Castelguidone,3 Rosario Vincenzo Iaffaioli,1 Salvatore Tafuto1 On behalf of the European Neuroendocrine Tumor Society (ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy 1Department of Abdominal Oncology, National Cancer Institute “Fondazione G. Pascale”, Naples, Italy; 2Department of Clinical Medicine and Surgery, “Federico II” University, Naples, Italy; 3Department of Radiology, 4Department of Pathology, 5Department of Endoscopy, National Cancer Institute “Fondazione G Pascale”, Naples, Italy Abstract: Somatostatin analogs (SSAs are typically used to treat the symptoms caused by neuroendocrine tumors (NETs, but they are not used as the primary treatment to induce tumor shrinkage. We report a case of a 63-year-old woman with a symptomatic metastatic NET of the ileum. Complete symptomatic response was achieved after 1 month of treatment with SSAs. In addition, there was an objective response in the liver, with the disappearance of secondary lesions noted on computed tomography scan after 3 months of octreotide treatment. Our experience suggests that SSAs could be useful for downstaging and/or downsizing well-differentiated NETs, and they could allow surgery to be performed. Such presurgery therapy could be a promising tool in the management of patients with initially inoperable NETs. Keywords: neuroendocrine tumor, somatostatin analogs, octreotide, metastatic tumor of the ileum, radiological tumor response

  2. Emerging targets in cancer management: role of the CXCL12/CXCR4 axis

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    Cojoc M

    2013-09-01

    Full Text Available Monica Cojoc,1 Claudia Peitzsch,1 Franziska Trautmann,1 Leo Polishchuk,2 Gennady D Telegeev,2 Anna Dubrovska11OncoRay National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; 2Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, UkraineAbstract: The chemokine CXCL12 (SDF-1 and its cell surface receptor CXCR4 were first identified as regulators of lymphocyte trafficking to the bone marrow. Soon after, the CXCL12/CXCR4 axis was proposed to regulate the trafficking of breast cancer cells to sites of metastasis. More recently, it was established that CXCR4 plays a central role in cancer cell proliferation, invasion, and dissemination in the majority of malignant diseases. The stem cell concept of cancer has revolutionized the understanding of tumorigenesis and cancer treatment. A growing body of evidence indicates that a subset of cancer cells, referred to as cancer stem cells (CSCs, plays a critical role in tumor initiation, metastatic colonization, and resistance to therapy. Although the signals generated by the metastatic niche that regulate CSCs are not yet fully understood, accumulating evidence suggests a key role of the CXCL12/CXCR4 axis. In this review we focus on physiological functions of the CXCL12/CXCR4 signaling pathway and its role in cancer and CSCs, and we discuss the potential for targeting this pathway in cancer management.Keywords: epithelial-to-mesenchymal transition, cancer stem cells, metastasis

  3. Bevacizumab treatment in the elderly patient with metastatic colorectal cancer

    Directory of Open Access Journals (Sweden)

    Di Bartolomeo M

    2015-01-01

    Full Text Available Maria Di Bartolomeo,1 Claudia Maggi,1 Francesca Ricchini,1 Filippo Pietrantonio,1 Roberto Iacovelli,1 Filippo de Braud,1 Alessandro Inno2 1Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 2Department of Medical Oncology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy Abstract: Metastatic colorectal cancer (mCRC, like many cancers, is primarily a disease of elderly people. Despite this prevalence, such patients are often excluded from randomized trials or represent a minority of enrolled patients. Moreover, the criteria for establishing benefit or side effects of treatment strategies in this population are uncertain and not well recognized. Bevacizumab improves the outcome of mCRC when used in combination with standard first-line and second-line chemotherapy and beyond the first disease progression when given with a chemotherapy backbone different from that used in the precedent line. The particular toxicity profile of this antiangiogenesis agent (in particular hypertension, thromboembolic events, hemorrhage, and renal failure may discourage its use in elderly patients with comorbidities. Data from subgroup analyses of randomized trials and the results of recent cohort studies suggest a significant benefit from the addition of bevacizumab to standard chemotherapy for elderly patients comparable with that observed in younger patients, except for the increased risk for thromboembolic events. Age alone should not be a barrier to use of bevacizumab, and further research with a more complete geriatric assessment should investigate the role of bevacizumab in elderly patients with mCRC to avoid undertreatment of this patient population due to a ­historical conservative approach. Keywords: bevacizumab, elderly, metastatic colorectal cancer, antivascular treatment, review

  4. Architettura e arte pubblica in Italia dopo il 1945. About and Context

    Directory of Open Access Journals (Sweden)

    Paola Valenti

    2017-05-01

    - Lisa Parola, storica dell’arte, curatrice, membro dell’Associazione culturale a.titolo, Arte e sfera pubblica: l’esperienza di Nuovi Committenti in Italia. - Cesare Viel, artista, docente presso l’Accademia Ligustica di Belle Arti di Genova, Spazi di pubblica riflessione. I mutevoli confini della relazione tra intimo e collettivo, provvisorio e durevole, latente e manifesto nella pratica artistica contemporanea. Al fine di restituire la complessità dei temi affrontati e la ricchezza del dibattito che ha accompagnato le relazioni, per il numero della rivista “on the w@terfront” si è deciso di operare una selezione degli interventi presentati al convegno riferiti al contesto italiano (Claudia Collina, Alessandra Barbuto, Lisa Parola, Cesare Viel e di integrarla con alcuni saggi, affidati ai giovani studiosi che hanno collaborato alla redazione del volume Arte negli edifici pubblici. L’applicazione della “legge del 2%” in Liguria dal 1949 ad oggi, che illustrano la metodologia seguita nell’ambito della ricerca sulla applicazione della legge del 2% in Liguria (Rocco Spigno, che presentano i più importanti interventi e progetti culturali che hanno interessato la città di Genova dal 1992, anno dell’Esposizione Colombiana che ha segnato una inversione di rotta per il capoluogo ligure, ad oggi (Alessandra Piatti, che riflettono su come l’arte pubblica abbia trovato, in Italia, un terreno di controcultura nel World Wide Web (Francesca Bulian. Il contributo di Paola Valenti, che apre la raccolta di saggi, si propone di presentare al lettore la realtà del capoluogo ligure da un punto di vista storico, architettonico, urbanistico e culturale, evidenziando soprattutto la sua peculiare condizione di città policentrica e in costante evoluzione.

  5. Neoadjuvant treatments in triple-negative breast cancer patients: where we are now and where we are going

    Directory of Open Access Journals (Sweden)

    Omarini C

    2018-01-01

    Full Text Available Claudia Omarini, Giorgia Guaitoli, Stefania Pipitone, Luca Moscetti, Laura Cortesi, Stefano Cascinu, Federico Piacentini Department of Medical and Surgical Sciences for Children & Adults, Division of Medical Oncology, University Hospital of Modena, Modena, Italy Abstract: Triple-negative breast cancer (TNBC remains the poorest-prognosis breast cancer (BC subtype. Gene expression profiling has identified at least six different triple-negative subtypes with different biology and sensitivity to therapies. The heterogeneous nature of TN tumors may justify the difficulty in treating this BC subtype. Several targeted agents have been investigated in clinical trials without demonstrating a clear survival benefit. Therefore, systemic chemotherapy remains the cornerstone of current clinical practice. Improving the knowledge of tumor biology is mandatory for patient management. In stages II and III, neoadjuvant systemic treatment is an effective option of care. The achievement of a pathological complete response represents an optimal surrogate for survival outcome as well as a test for tumor drug sensitivity. In this review, we provide a brief description of the main predictive biomarkers for tumor response to systemic treatment. Moreover, we review the treatment strategies investigated for TNBCs in neoadjuvant settings focusing on experimental drugs such as immunotherapy and poly [ADP-ribose] polymerase inhibitors that hold promise in the treatment of this aggressive disease. Therefore, the management of TNBC represents an urgent, current, unmet need in daily clinical practice. A key recommendation is to design biology-driven clinical trials wherein TNBC patients may be treated on the basis of tumor molecular profile. Keywords: triple-negative breast cancer, neoadjuvant chemotherapy, BRCA, platinum, immunotherapy, PARP-1 inhibitors

  6. New developments in the management of relapsed/refractory multiple myeloma – the role of ixazomib

    Directory of Open Access Journals (Sweden)

    Richardson PG

    2017-08-01

    Full Text Available Paul G Richardson,1 Shaji Kumar,2 Jacob P Laubach,1 Claudia Paba-Prada,1 Neeraj Gupta,3 Deborah Berg,3 Helgi van de Velde,3 Philippe Moreau4 1Division of Hematologic Malignancy, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA, USA; 2Division of Hematology, Mayo Clinic, Rochester, MN, USA; 3Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA; 4Hematology Department, University Hospital Hotel-Dieu, Nantes, France Abstract: Ixazomib is the first oral proteasome inhibitor to be approved, in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was on the basis of results from the phase 3, double-blind, placebo-controlled TOURMALINE-MM1 study, which demonstrated a 35% improvement in progression-free survival with the all-oral combination of ixazomib plus lenalidomide–dexamethasone versus lenalidomide–dexamethasone alone (median: 20.6 vs 14.7 months; hazard ratio: 0.74, p=0.012; median follow-up 14.7 months. The addition of ixazomib to the lenalidomide–dexamethasone regimen was associated with limited additional toxicity and had no adverse impact on patient-reported quality of life. Common grade ≥3 adverse events with ixazomib include gastrointestinal adverse events, rash, and thrombocytopenia. Here, we review the efficacy, safety, pharmacokinetics, and patient-reported quality of life data seen with ixazomib, and discuss the role of this oral agent in the treatment of patients with relapsed/refractory multiple myeloma, including in patients with high-risk cytogenetic abnormalities and those with multiple prior therapies. Keywords: ixazomib, multiple myeloma, proteasome inhibitor, clinical, efficacy, tolerability, pharmacokinetics 

  7. ENSI Approach to Oversight of Safety Culture

    International Nuclear Information System (INIS)

    Humbel Haag, Claudia

    2012-01-01

    Claudia Humbel Haag presented developments in ENSI approach to safety culture oversight. ENSI has developed a definition/understanding of Safety Culture and a concept of how to perform oversight of Safety Culture. ENSI defines safety culture in the following way: Safety Culture comprises the behaviour, world views (in the sense of conceptualisations of reality and explanation models), values (in the sense of aims and evaluation scales), and features of the physical environment (specifically, the nuclear power plant and the documents used) which are shared by many members of an organization, in as much as these are of significance to nuclear safety. A model of the accessibility of safety culture was presented ranging from the observable (external aspects of safety culture), to aspects that are accessible by asking questions, through to aspects that are not accessible (internal part of safety culture). ENSI considers observable aspects through the existing systematic safety assessment compliance program. Aspects that are observable by asking questions will be addressed by additional oversight activities outside the systematic assessment program. Aspects that are not accessible are addressed by helping the licensee to re-think its safety culture through proactive discussions on safety culture. Reports are issued to the licensee on assumptions and observations identified through the discussions. The conclusions of the presentation emphasised the importance of basing any interventions in this area on a solid understanding of the concept of safety culture. ENSI safety culture oversight principles were also described. These include licensee responsibility for safety, and the need for the regulator to critically review their own activities to ensure a positive influence on the licensee

  8. O gigante adormecido vem pra rua: construções enunciativas de Johnnie Walker e Fiat durante as manifestações brasileiras de 2013

    Directory of Open Access Journals (Sweden)

    Carolina Fernandes da Silva Mandaji

    2014-04-01

    Full Text Available O tema deste trabalho são as manifestações ocorridas nos meses de junho e julho de 2013 em todo o Brasil. Trata-se de uma reflexão sobre as construções enunciativas de discursos midiáticos no cenário nacional e internacional.  Esta investigação se propõe a entender os processos enunciativos, e portanto, discursivos e interacionais no uso da materialidade sincrética e audiovisual de anúncios publicitários das marcas Johnnie Walker e Fiat. Tanto a campanha “Keep walking, Brazil” como  a “Vem pra rua” da Fiat foram (re contextualizadas em outros processos enunciativos durante as manifestações brasileiras. Será possível identificar que tipo de interação discursiva ocorre entre marcas e público a partir de tal (re contextualização? Qual relação enunciativa existe entre as marcas e as manifestações e quais são os papeis enunciativos e discursivos propostos por tal relação?  Tais perguntas irão nos levar ao contexto de produção das campanhas, mas também a uma nova apreensão de sentido pautada por processos enunciativos que não os das próprias marcas, mas sim, de novas posições enunciativas. A base metodológica guia-se pelos estudos da Semiótica Discursiva de A. J. Greimas e pelos pressupostos teóricos da Sociossemiótica proposto por Eric Landowski e nas pesquisas de Ana Claudia de Oliveira.

  9. In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

    Directory of Open Access Journals (Sweden)

    Baldi G

    2014-06-01

    Full Text Available Giovanni Baldi,1 Costanza Ravagli,1 Filippo Mazzantini,1 George Loudos,2 Jaume Adan,3 Marc Masa,3 Dimitrios Psimadas,2 Eirini A Fragogeorgi,2 Erica Locatelli,4 Claudia Innocenti,5,6 Claudio Sangregorio,5,7 Mauro Comes Franchini4 1CERICOL, Sovigliana-Vinci, Italy; 2Technological Educational Institute of Athens, Athens, Greece; 3Leitat Technological Center, Barcelona, Spain; 4Department of Industrial Chemistry Toso Montanari, University of Bologna, Bologna, 5Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM, 6Dipartimento di Chimica U Schiff, Università di Firenze, Firenze, 7Centro Nazionale delle Ricerche (ICCOM – CNR, Firenze, Italy Abstract: Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide-co-glycolide-b-poly(ethylene glycol-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99mTc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99mTc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma. Keywords: magnetic nanoparticles, polymeric nanocarriers, skin cancer, hyperthermia, single-photon emission computed tomography, imaging

  10. An interactive modelling tool for understanding hydrological processes in lowland catchments

    Science.gov (United States)

    Brauer, Claudia; Torfs, Paul; Uijlenhoet, Remko

    2016-04-01

    Recently, we developed the Wageningen Lowland Runoff Simulator (WALRUS), a rainfall-runoff model for catchments with shallow groundwater (Brauer et al., 2014ab). WALRUS explicitly simulates processes which are important in lowland catchments, such as feedbacks between saturated and unsaturated zone and between groundwater and surface water. WALRUS has a simple model structure and few parameters with physical connotations. Some default functions (which can be changed easily for research purposes) are implemented to facilitate application by practitioners and students. The effect of water management on hydrological variables can be simulated explicitly. The model description and applications are published in open access journals (Brauer et al, 2014). The open source code (provided as R package) and manual can be downloaded freely (www.github.com/ClaudiaBrauer/WALRUS). We organised a short course for Dutch water managers and consultants to become acquainted with WALRUS. We are now adapting this course as a stand-alone tutorial suitable for a varied, international audience. In addition, simple models can aid teachers to explain hydrological principles effectively. We used WALRUS to generate examples for simple interactive tools, which we will present at the EGU General Assembly. C.C. Brauer, A.J. Teuling, P.J.J.F. Torfs, R. Uijlenhoet (2014a): The Wageningen Lowland Runoff Simulator (WALRUS): a lumped rainfall-runoff model for catchments with shallow groundwater, Geosci. Model Dev., 7, 2313-2332. C.C. Brauer, P.J.J.F. Torfs, A.J. Teuling, R. Uijlenhoet (2014b): The Wageningen Lowland Runoff Simulator (WALRUS): application to the Hupsel Brook catchment and Cabauw polder, Hydrol. Earth Syst. Sci., 18, 4007-4028.

  11. A gagueira sob diferentes olhares: análise comparativa das abordagens de quatro autoras Stuttering under different prisms: the comparative analysis based on four specialists

    Directory of Open Access Journals (Sweden)

    Rosivânia de Almeida Moraes

    2007-09-01

    Full Text Available OBJETIVO: analisar comparativamente quatro abordagens em gagueira quanto aos aspectos definição, etiologia, avaliação, terapia; demonstrar justificativas para a ausência de disfluências gagas no monólogo. MÉTODOS: revisão bibliográfica sistemática das publicações das autoras: Ana Maria Schiefer, Claudia Regina Furquim de Andrade, Silvia Friedman e Isis Meira, designadas como abordagens 1, 2, 3, 4. RESULTADOS: assemelham-se em: Definição - 1 e 2 quanto ao caráter descritivo, 2 e 3 quanto a auto-avaliação; Etiologia: 1, 2 e 4 quanto ao fator orgânico, 2, 3 e 4 quanto a implicação psicológica, 2 e 3 quanto a ambiental; Avaliação - 1 e 2 quanto ao critério quantitativo, 1, 2, 3 e 4 quanto ao qualitativo; Terapia - 1 e 2. A ausência de disfluências gagas se justificou pelas perspectivas: em 1, pressão do tempo e pragmática; em 2, ajuste neurolinguístico e motor; em 3, paradoxo básico, em 4, antecipação, ansiedade e medo. CONCLUSÃO: 1 e 2 se assemelham quanto definição, etiologia, avaliação, terapia; 1 e 3 quanto avaliação; 2 e 3 quanto definição, etiologia, avaliação; 1 e 4, 2 e 4, 3 e 4 quanto etiologia, avaliação, terapia. As semelhanças mostraram-se parciais, dada a especificidade do referencial teórico de cada abordagem. A ausência de disfluências gagas justificou-se pela inexistência da necessidade de ajuste ao interlocutor e de intenção comunicativa em 1, de ajuste na formulação lingüística e temporal em 2, pela ausência de receio de julgamento em 3, de antecipação, ansiedade e medo em 4.PURPOSE: this research is a comparative analysis between four different approaches on stuttering, by investigating the line of scientific thought of each author, definition, etiology, evaluation, therapy and raises some hypothesis to justify the absence of dysfluency in a monologue. METHODS: a systematic bibliographic revision of the authors' publications: Ana Maria Schiefer, Claudia Regina Furquim de

  12. Five-year review of an international clinical research-training program

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    Suemoto CK

    2015-04-01

    Full Text Available Claudia Kimie Suemoto,1,2 Sherine Ismail,1,3 Paulo César Rodrigues Pinto Corrêa,1,4,5 Faiza Khawaja,1,6 Teodoro Jerves,1 Laura Pesantez,1 Ana Claudia Camargo Gonçalves Germani,1,7 Fabio Zaina,1,8 Augusto Cesar Soares dos Santos Junior,1,9,10 Ricardo Jorge de Oliveira Ferreira,1,11 Priyamvada Singh,1,12 Judy Vicente Paulo,1,13 Suely Reiko Matsubayashi,1,14 Liliane Pinto Vidor,1,15 Guilherme Andretta,1,16 Rita Tomás,1,17 Ben MW Illigens,1,18 Felipe Fregni1,18,19 1Collaborative Learning in Clinical Research Program, Principles and Practice of Clinical Research (PPCR, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 2Discipline of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil; 3King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Pharmaceutical Care Department, King Khalid Hospital, NGHA, Jeddah, Saudi Arabia; 4Discipline of Internal Medicine and Medical Semiology, Department of Internal Medicine, Federal University of Ouro Preto (UFOP Medical School, Ouro Preto, Brazil; 5Discipline of Pneumology, Department of Internal Medicine, Centro Universitário de Belo Horizonte (Uni-BH, Belo Horizonte, Brazil; 6Canadian Centre for Advanced Eye Therapeutics, Mississauga, ON, Canada; 7Department of Preventive Medicine, University of São Paulo Medical School, São Paulo, Brazil; 8Italian Scientific Spine Institute (ISICO, Milan, Italy; 9Hospital Osvaldo Rezende Franco, Betim, Brazil; 10Nucleo de Avaliação de Tecnologia em Saude, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; 11Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 12Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA; 13Portuguese Institute of Oncology, Coimbra, Portugal; 14Acupuncture

  13. Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo®

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    Paolo Solla

    2010-08-01

    Full Text Available Paolo Solla, Antonino Cannas, Francesco Marrosu, Maria Giovanna MarrosuMovement Disorders Center, Institute of Neurology, University of Cagliari, Cagliari, ItalyAbstract: Parkinson disease (PD is a neurodegenerative disorder characterized by 3 cardinal motor symptoms: resting tremor, rigidity, and bradykinesia. Since its introduction 40 years ago, levodopa has represented the gold standard for dopaminergic stimulation therapy in patients with PD. Levodopa is routinely combined with a dopa-decarboxylase inhibitor (DDCI to prevent the conversion of levodopa into dopamine in peripheral circulation. However, up to 80% of patients treated with continuous levodopa manifest the onset of disabling motor complications capable of producing an adverse effect on quality of life as the disease progresses. In recent years, a new, safe, and efficacious armamentarium of treatment options has been provided by the marketing of the catechol-O-methyltransferase (COMT inhibitor, entacapone, a peripheral blocker of dopa to 3-0-methyldopa metabolism, which increments levodopa brain availability. When administered with levodopa, entacapone conjugates the rapid onset of levodopa-induced effects with a protracted efficiency, thus providing additional benefits to classic levodopa treatment by increasing “on” time in fluctuating PD patients, and theoretically providing a more continuous and physiological-like stimulation of dopamine receptors implying a reduced risk of motor complications. In this context, the use of a single administration of combined ­carbidopa/levodopa/entacapone (Stalevo® in the treatment of PD affords clinical improvements similar to those obtained by 2 separate tablets (ie, levodopa/DDCI and entacapone, although the former produces a more positive effect on quality of life than the latter. Additionally, the STalevo Reduction In Dyskinesia Evaluation (STRIDE-PD study was designed with the aim of demonstrating that the combination of levodopa

  14. Proceedings of the 20th ASPA Congress, Bologna, June 11-13, 2013

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    Guest Editors: A. Piva, P. Bosi, A. Bonaldo, F. Sirri, A. Badiani, G. Biagi, R. Davoli, G. Martelli, A. Meluzzi, P. Trevisi

    2013-06-01

    Full Text Available The 20th Congress of the Animal Science and Production Association (ASPA, is held in the prestigious home of the oldest university of the world: Bologna. The anniversary also celebrates the 40th year of the founding of the Society and is an occasion to remember the past and plan for the future of Animal Sciences in Italy. In this Congress, 137 oral presentations and 155 posters are presented, for a total of 292 scientific contributions. The Congress sessions with their relative number of papers are listed as follows: Animal breeding and genetics 109, Nutrition and feeding 45, Dairy production 42, Animal welfare, health and behaviour 39, Meat quality 35, Poultry and rabbit production 11 and Aquaculture 11. I would like to point out that 3 main lectures will be presented in the Animal breeding and genetics, Nutrition and feeding and Animal welfare, health and behaviour sessions, respectively. I would thank, first of all, Prof. Vincenzo Russo, Honorary President of the Congress and Emeritus of ASPA, for the contribution of the University of Bologna in organizing this event. I would also thank all the members of the Scientific Committee, Prof. Andrea Piva (Chairperson, Prof. Anna Badiani, Prof. Giacomo Biagi, Dr. Alessio Bonaldo, Prof. Paolo Bosi, Prof. Roberta Davoli, Prof. Luca Fontanesi, Prof. Giovanna Martelli, Prof. Adele Meluzzi, Dr. Attilio Mordenti, Prof. Luca Sardi, Dr. Federico Sirri, Dr. Paolo Trevisi, and of the Organizing Committee, Prof. Claudio Cavani (Chairperson, Prof. Stefania Dall’Olio, Prof. Andrea Formigoni, Prof. Pier Giorgio Monetti, Prof. Leonardo Nanni Costa, Dr. Massimiliano Petracci, Prof. Giuliano Zaghini, Dr. Paolo Zambonelli. A special thanks to the secretary of the Congress, MV Congressi. Indeed, I would like to congratulate and thank all those who have organized the meeting and have collaborated in reviewing the summaries for what they have done for ASPA and the Italian Animal Science. A special thanks to Prof

  15. Incidence and costs of hip fractures vs strokes and acute myocardial infarction in Italy: comparative analysis based on national hospitalization records

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    Piscitelli P

    2012-12-01

    Full Text Available Prisco Piscitelli,1,2 Giovanni Iolascon,3 Alberto Argentiero,2 Giovanna Chitano,2 Cosimo Neglia,2 Gemma Marcucci,1 Manuela Pulimeno,2 Marco Benvenuto,2 Santa Mundi,2 Valentina Marzo,2 Daniela Donato,4 Angelo Baggiani,4 Alberto Migliore,5 Mauro Granata,6 Francesca Gimigliano,3 Raffaele Di Blasio,7 Alessandra Gimigliano,3 Lorenzo Renzulli,7 Maria Luisa Brandi,1 Alessandro Distante,2,4 Raffaele Gimigliano3,71University of Florence, Florence Italy; 2ISBEM Research Centre, Brindisi, Italy; 3Second University of Naples, Naples, Italy; 4University of Pisa, Pisa, Italy; 5Fatebenefratelli St Peter’s Hospital, Rome, Italy; 6St Filippo Neri Hospital, Rome, Italy; 7Casa di Cura Santa Maria del Pozzo, Somma Vesuviana, ItalyObjectives: As osteoporotic fractures are becoming a major health care problem in countries characterized by an increasing number of older adults, in this study we aimed to compare the incidence and costs of hip fragility fractures in Italian elderly people versus those of major cardiovascular diseases (strokes and acute myocardial infarctions [AMI] occurring in the whole adult population.Methods: We analyzed hospitalization records maintained at the national level by the Italian Ministry of Health for the diagnosis of hip fractures (ICD-9-CM codes 820–821, AMI (code 410, hemorrhagic (codes 430, 431, 432 and ischemic strokes (codes 433–434, and TIA (code 435 between 2001–2005. Cost analyses were based on diagnosis-related groups.Results: The incidence of hip fractures in elderly people has increased (+12.9% between 2001 and 2005, as well as that of AMI (+20.2% and strokes (hemorrhagic: +9.6%; ischemic: +14.7 occurring in the whole adult population; conversely, hospitalization due to TIA decreased by a rate of 13.6% between 2001 and 2005. In 2005, the hospital costs across the national health care system that were associated with hip fragility fractures in the elderly were comparable to those of strokes (both hemorrhagic and

  16. Microparticles in sputum of COPD patients: a potential biomarker of the disease?

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    Lacedonia D

    2016-03-01

    Full Text Available Donato Lacedonia,1,* Giovanna Elisiana Carpagnano,1,* Teresa Trotta,2 Grazia Pia Palladino,1 Maria Antonietta Panaro,3 Liugi Davide Zoppo,1 Maria Pia Foschino Barbaro,1 Chiara Porro21Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 3Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy*These authors contributed equally to this workBackground: Microparticles (MPs are small membrane vesicles of 0.1–1 µm which are released by cells following chemical, physical, and apoptotic stimuli. MPs represent more than a miniature version of the cell. Their composition and function depend not only on cellular origin, but also on stimuli. Chronic obstructive pulmonary disease (COPD is a lung disease characterized by nearly irreversible lung destruction which results in airway limitation.Purpose: We investigated the presence and source of MPs in sputum of COPD patients to evaluate if changes in MP number and origin may reflect the pathophysiological conditions of disease and may serve as potential biomarkers for diagnostic and prognostic use.Methods: Induced sputum samples were collected from 18 male subjects and liquefied with Sputasol. MPs obtained were immunolabeled for leukocyte (CD11a, granulocyte (CD66b, monocyte-macrophage (CD11b, platelets and megakaryocytic cells (CD41, endothelial cells (CD31, and red blood cells (CD235ab and analyzed by cytofluorimetry.Results: There was a negative correlation between CD31-MPs and forced expiratory volume in 1 second (R=−53, P<0.05 and CD66b-MP level was correlated with worse performance index of COPD such as the Body mass index airflow Obstruction, Dyspnea, and Exercise capacity (BODE; they were negatively correlated with 6-minute walking test: 0.65 and −0.64, respectively (P<0.05. CD235ab-MPs showed a negative correlation with body mass index (R=−0.86, P

  17. A performance da voz e a subjetividade na poesia contemporânea

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    Olliver Mariano Rosa e Goiandira Ortiz de Camargo

    2013-10-01

    Full Text Available http://dx.doi.org/10.5007/2176-8552.2013n15p205 Neste artigo, tratamos da relação que se estabelece entre o sujeito leitor e a subjetividade configurada no poema contemporâneo. Para isso, consideramos a performance vocal como instrumento de compreensão do texto poético, a despeito de hoje preponderar o uso do suporte impresso para sua publicação. Acreditamos que, na medida em que a feitura do poema implica a manipulação da materialidade sonora da palavra, a sua leitura precisa recorrer à escuta de uma voz, ainda que apenas como virtualidade. Constatamos, no entanto, que a realização vocal não dá a conhecer apenas o ritmo, o andamento e a entoação do verso; por meio dela, evidencia-se a presença da subjetividade que se manifesta na composição lírica. Nesse ponto, torna-se importante a observação de que a poesia abriga no mundo contemporâneo uma diversidade de configurações dadas por um sujeito criador múltiplo. Considerando isso, tomamos para estudo poemas de poetas contemporâneos, três portugueses, Fiama Hasse Pais Brandão, Ana Luísa Amaral e Manuel de Freitas, e três brasileiros, Francisco Alvim, Neide Archanjo e Claudia Roquette-Pinto. Com base na leitura desses poemas, propomos uma classificação das diferentes ocorrências do princípio subjetivo. Verificamos, por fim, de que forma a performance da voz entra em jogo com essas ocorrências. OBS: Olliver Mariano Rosa é bolsista do CNPq.

  18. The merits and problems of Neuropsychiatric Inventory as an assessment tool in people with dementia and other neurological disorders

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    Lai CKY

    2014-07-01

    Full Text Available Claudia KY LaiSchool of Nursing, The Hong Kong Polytechnic University, Special Administrative Region of the People’s Republic of China Objective: The Neuropsychiatric Inventory (NPI is one of the most commonly used ­assessment scales for assessing symptoms in people with dementia and other neurological disorders. This paper analyzes its conceptual framework, measurement mode, psychometric properties, and merits and problems.Method: All articles discussing the psychometric properties and factor structure of the NPI were searched for in Medline via Ovid. The abstracts of these papers were read to determine their relevance to the purpose of this paper. If deemed appropriate, a full paper was then obtained and read. Results: The NPI has reasonably good content validity and internal consistency, and good test–retest and interrater reliability. There is limited information about its sensitivity, specificity, positive and negative predictive values, and, in particular, responsiveness. Merits of the NPI include being comprehensive, avoiding symptom overlap, ease of use, and flexibility. It has problems in scoring (no multiples of 5, 7, and 11 and, therefore, analysis using parametric tests may not be appropriate. The use of individual subscales also warrants further investigation.Conclusion: In terms of its content and concurrent validity, intra- and interrater reliability, test–retest reliability, and internal consistency, the NPI can be considered as valid and reliable, and can be used across different ethnic groups. The tool is most likely unable to deliver as good a performance in terms of discriminating between different disorders. More studies are required to further evaluate its psychometric properties, particularly in the areas of factor structure and responsiveness. The clinical utility of the NPI also needs to be further explored. Keywords: measurement, neuropsychiatric symptoms, outcome assessment

  19. オースティン作品の女友達：Northanger Abbey を中心に

    OpenAIRE

    ブラウン馬本, 鈴子

    2017-01-01

    フェミニズムでは、女友達の存在は、女性が自立を図る上で重要であると考えられている。作家ジェイン・オースティンの作品では女性同士の“ real friendship”は存在するのであろうか。本稿では初期の作品であるNorthanger Abbey（1818）の女主人公Catherine Morland とその友人Isabella Thorpe やTilney 兄妹との友情を中心に、オースティン作品の中で女友達を登場させる意義の解読を試みた。Isabella との浅はかな友情を通して、彼女の狡猾で浮気性な本性が露呈されると同時に、主人公の〈単純〉〈純粋〉〈未熟〉な性格が強調される現象を確認した。また精読によってIsabella の友情の動機が、Catherine を利用して結婚相手を獲得することであることを明らかにした。やがてCatherineの友情は、IsabellaからTilney兄妹へと舵を切るが、Claudia L. Johnsonの指摘“ The band of good friends is all related by marriage in the end”にあるよう...

  20. DSM-5 PTSD and posttraumatic stress spectrum in Italian emergency personnel: correlations with work and social adjustment

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    Carmassi C

    2016-02-01

    Full Text Available Claudia Carmassi,1 Camilla Gesi,1 Marly Simoncini,1 Luca Favilla,1 Gabriele Massimetti,1 Maria Cristina Olivieri,1 Ciro Conversano,2 Massimo Santini,2 Liliana Dell’Osso1 1Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy; 2Emergency Medicine and Emergency Room Unit, Azienda Ospedaliero-Universitaria Pisana (AOUP, Pisa, Italy Abstract: The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5 has recently recognized a particular risk for posttraumatic stress disorder (PTSD among first responders (criterion A4, acknowledging emergency units as stressful places of employment. Little data is yet available on DSM-5 among emergency health operators. The aim of this study was to assess DSM-5 symptomatological PTSD and posttraumatic stress spectrum, as well as their impact on work and social functioning, in the emergency staff of a major university hospital in Italy. One hundred and ten subjects (doctors, nurses, and health-care assistants were recruited at the Emergency Unit of the Azienda Ospedaliero-Universitaria Pisana (Italy and assessed by the Trauma and Loss Spectrum-Self Report (TALS-SR and Work and Social Adjustment Scale (WSAS. A 15.7% DSM-5 symptomatological PTSD prevalence rate was found. Nongraduated persons reported significantly higher TALS-SR Domain IV (reaction to loss or traumatic events scores and a significantly higher proportion of individuals presenting at least one maladaptive behavior (TALS-SR Domain VII, with respect to graduate ones. Women reported significantly higher WSAS scores. Significant correlations emerged between PTSD symptoms and WSAS total scores among health-care assistants, nongraduates and women. Our results showed emergency workers to be at risk for posttraumatic stress spectrum and related work and social impairment, particularly among women and nongraduated subjects. Keywords: posttraumatic stress disorder (PTSD, emergency, emergency

  1. Development of a Healthy Lifestyle Mobile App for Overweight Pregnant Women: Qualitative Study.

    Science.gov (United States)

    Lau, Ying; Cheng, Ling Jie; Chi, Claudia; Tsai, Cammy; Ong, Kai Wen; Ho-Lim, Sarah Su Tin; Wang, Wei; Tan, Kian-Lee

    2018-04-23

    Mobile apps are becoming an increasingly ubiquitous platform for delivery of health behavior interventions among overweight and obese perinatal women. However, only a few methodological guidelines on integrating theory, evidence, and qualitative research for their designs are available. The aim of this study was to develop a theory-based, evidence-driven, and user-centered healthy lifestyle app targeting overweight and obese multiethnic pregnant women. This paper illustrates how intervention development may be enriched with theoretical basis, systematic review, and qualitative study. An individual face-to-face interview was performed to incorporate the user's involvement in the design. These interviews were audiotaped and transcribed. Thematic analysis technique was used for emerging themes. Integrated concepts of social cognitive theory of self-regulation, self-regulation model, and strength model of self-control were selected as bases of the intervention. Evidence from our systematic review and meta-analysis provided the strongest evidence for the development of intervention. We invited 16 obese or overweight pregnant women to participate in a semistructured interview . The following key themes emerged: content, platform, interactivity, format, and functionality. Apps are a favorable technology platform for healthy diet advice, appropriate physical exercise, and weight management because they are user-friendly and convenient. The app used in this study contains culture-specific, pregnancy-related, and credible contents, including educational, professional and peer support, and self-monitoring domains. The design should include aesthetic appeal, visualized features, and interactive multimedia. A 3-step process integrating theoretical basis, evidence from systematic review, and research findings from target users can be considered a guide for future app development. ©Ying Lau, Ling Jie Cheng, Claudia Chi, Cammy Tsai, Kai Wen Ong, Sarah Su Tin Ho-Lim, Wei Wang

  2. Rosetta at Perihelion: The Journey Continues

    Science.gov (United States)

    Weissman, Paul R.; Taylor, Matthew; Alexander, Claudia J.

    2015-11-01

    ESA’s Rosetta spacecraft, with participation by NASA, has been in orbit around the nucleus of comet 67P/Churyumov-Gerasimenko for over one year. It has been a year of great discoveries and accomplishments, including the first successful spacecraft landing on the surface of a cometary nucleus (and the second and the third landings). The discoveries include 1) the unusual shape of the bi-lobed nucleus, 2) the substantial change of the nucleus rotation period (which continues to evolve), 3) the high dust-to-gas ratio, 4 ± 1 (by mass), 4) the low bulk density of the nucleus, 0.50 g/cm3, 5) the high deuterium/hydrogen ratio of the coma water molecules, 5.3 x 10-4, more than 3 times the terrestrial value, 6) the highly complex and different terrains on the nucleus surface, 7) the lack of any intrinsic magnetic field, 8) the existence of cylindrical pits in the nucleus surface, typically ~200 m in diameter and ~180 m deep, 9) the existence of “goose bump” terrain, which may provide clues to the accretion of the comet nucleus, 10) the existence of many similarly-sized boulders on the nucleus surface, and much more. The spacecraft and comet passed through perihelion on August 13, 2015, which has been marked by substantial, volatile-rich outbursts from the cometary nucleus. The Rosetta mission has now been extended to September, 2016, when the comet and spacecraft will be approaching 4 AU, outbound from the Sun. This talk is dedicated to the memory of Dr. Claudia J. Alexander, U.S. Rosetta Project Scientist, who passed away in July of this year. Her tireless efforts and tremendous enthusiasm on behalf of Rosetta contributed greatly to the success of the mission.

  3. Apresentação do Dossiê

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    Maria Cecília Coelho

    2013-12-01

    Full Text Available Este dossiê reúne textos apresentados, em sua maioria, durante o XIX Congresso da Sociedade Brasileira de Estudos Clássicos e no decorrer do I Simpósio Luso-Brasileiro de Estudos Clássicos – O Futuro do Passado, que aconteceu em julho de 2013, em Brasília/Distrito Federal. O dossiê contém quatro artigos e um ensaio, lido em uma palestra, ao qual segue anexo um comentário de seu moderador. Três dos artigos são frutos do painel proposto e organizado, durante o XIX Congresso, pelo Núcleo de Estudos Antigos e Medievais da Faculdade de Letras da Universidade Federal de Minas Gerais (NEAM/FALE/UFMG, do qual sou membro. No painel, intitulado “Recepção da cultura greco-romana no cinema, no teatro e na literatura”, foram apresentados textos de autoria de professores da área de língua e literatura gregas, que trabalham na Argentina, nos Estados Unidos e na Polônia: Claudia Fernández (Universidade de La Plata, Eric Dugdale (Gustavus Adolphus College e Ewa Skwara (Adam-Mickiewicz University, respectivamente. Quanto ao ensaio, trata-se do texto do cineasta português João Canijo, em cuja obra se destaca a adaptação de tragédias gregas para o cinema. O ensaio é seguido do comentário de Christian Werner (Universidade de São Paulo, tradutor e professor de língua e literatura gregas. O quarto artigo, de minha autoria, apesar de ter sido resultado, em parte, de uma palestra que apresentei em outro momento (no VI Colóquio Filosofia e Ficção – Phantasia e Phantasmas, foi, pela proximidade com o tema do painel que coordenei nesse XIX Congresso, inserido neste dossiê.

  4. Role of etelcalcetide in the management of secondary hyperparathyroidism in hemodialysis patients: a review on current data and place in therapy

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    Friedl C

    2018-06-01

    Full Text Available Claudia Friedl,1 Emanuel Zitt2 1Department of Internal Medicine, Clinical Division of Nephrology, Medical University of Graz, Graz, 2Department of Internal Medicine III, Nephrology and Dialysis, Feldkirch Academic Teaching Hospital, Feldkirch, Austria Abstract: Secondary hyperparathyroidism (sHPT is a frequently occurring severe complication of advanced kidney disease. Its clinical consequences include extraskeletal vascular and valvular calcifications, changes in bone metabolism resulting in renal osteodystrophy, and an increased risk of cardiovascular morbidity and mortality. Calcimimetics are a cornerstone of parathyroid hormone (PTH-lowering therapy, as confirmed by the recently updated 2017 Kidney Disease: Improving Global Outcomes chronic kidney disease – mineral and bone disorder clinical practice guidelines. Contrary to calcitriol or other vitamin D-receptor activators, calcimimetics reduce PTH without increasing serum-calcium, phosphorus, or FGF23 levels. Etelcalcetide is a new second-generation calcimimetic that has been approved for the treatment of sHPT in adult hemodialysis patients. Whereas the first-generation calcimimetic cinacalcet is taken orally once daily, etelcalcetide is given intravenously thrice weekly at the end of the hemodialysis session. Apart from improving drug adherence, etelcalcetide has proven to be more effective in lowering PTH when compared to cinacalcet, with an acceptable and comparable safety profile. The hope for better gastrointestinal tolerance with intravenous administration did not come true, as etelcalcetide did not significantly mitigate the adverse gastrointestinal effects associated with cinacalcet. Enhanced adherence and strong reductions in PTH, phosphorus, and FGF23 could set the stage for a future large randomized controlled trial to demonstrate that improved biochemical control of mineral metabolism with etelcalcetide in hemodialysis patients translates into cardiovascular and survival

  5. Tolerability and camouflaging effect of corrective make-up for acne: results of a clinical study of a novel face compact cream

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    Monfrecola G

    2016-10-01

    Full Text Available Giuseppe Monfrecola, Sara Cacciapuoti, Claudia Capasso, Mario Delfino, Gabriella Fabbrocini Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy Background: A novel face compact cream (FCC containing a new patented formulation was recently developed to provide acne patients with cosmetic camouflage for their lesions and to have beneficial effects on the multifactorial components of the disease. This pilot investigation aimed to evaluate the real-life tolerability, potential for comedogenicity and covering effect provided by this FCC.Methods: This single-center study evaluated the FCC applied once daily for 28 days in 20 females with facial acne. Tolerability was assessed by rating skin reactions on a scale from 1 =absent to 4 =evident. Comedogenicity potential was evaluated by determining the number of facial acne lesions before and after use of the FCC. The covering effect was rated in ten patients 30 minutes after application on a scale from 1 =none to 5 =excellent. Patients rated their opinions on the FCC on day 28 using a questionnaire.Results: Assessment of tolerability on days 0, 14, and 28 showed that skin reactions, including erythema, edema, dryness, desquamation, tight feeling, itching, and burning, were absent in all patients. The FCC was noncomedogenic and provided a significant 15.8% reduction in facial acne lesions after 28 days (P<0.001. The FCC provided a good covering effect 30 minutes after application in 80% of patients. All patients (100% were satisfied with the FCC, with 90% agreeing that the FCC was effective and 80% stating that the FCC improved their skin.Conclusion: The FCC was positively perceived, well tolerated, noncomedogenic, and provided an effective covering of acne in this small group of female patients with 1 month of follow-up. Keywords: acne, comedones, dermatocosmetic, tolerability

  6. O índio na fotografia brasileira: incursões sobre a imagem e o meio The Indian in Brazilian photography: incursions into image and medium

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    Fernando de Tacca

    2011-03-01

    Full Text Available Pretende-se explorar contradições e confluências entre o meio (fotográfico e a imagem do índio brasileiro sob uma perspectiva histórica da fotografia brasileira. A imagem do índio nessa fotografia manifesta-se em três momentos distintos. Na fase inicial, no lugar do exótico, contraditório ao sentido moderno da fotografia durante o Segundo Império. Na segunda fase, as fronteiras entre o etnográfico e o nacional se diluem, nos primeiros cinquenta anos do século XX, a exemplo da Comissão Rondon/Seção de Estudos do SPI e do fotojornalismo moderno no Brasil da revista O Cruzeiro. No terceiro momento, as manifestações de uma etnopoética das fotografias de Claudia Andujar fazem meio e imagem se fundirem como lugar etnográfico na arte contemporânea.The article explores contradictions and convergences between a medium (photography and the image of the Brazilian Indian from the perspective of the history of Brazilian photography. During the first of three distinct moments, the image of the Indian was of someone exotic, in contradiction with the modern meaning of photography under the Second Empire. During the second moment, in the first fifty years of the twentieth century, the boundaries between ethnography and Brazil as a nation were blurred, as exemplified by the Rondon Commission/Indian Protection Bureau's Research Section (Serviço de Proteção ao Índio and Brazil's modern photojournalism, as found in the magazine Cruzeiro. During the third moment, the expressions of an ethno-poetry present in the photographs of Cláudia Andujar can be seen to blend medium and image as an ethnographic space in contemporary art.

  7. Courage as a skill.

    Science.gov (United States)

    Reardon, Kathleen K

    2007-01-01

    A division vice president blows the whistle on corruption at the highest levels of his company. A young manager refuses to work on her boss's pet project because she fears it will discredit the organization. A CEO urges his board, despite push back from powerful, hostile members, to invest in environmentally sustainable technology. What is behind such high-risk, often courageous acts? Courage in business, the author has found, seldom resembles the heroic impulsiveness that sometimes surfaces in life-or-death situations. Rather, it is a special kind of calculated risk taking, learned and refined over time. Taking an intelligent gamble requires an understanding of what she calls the "courage calculation": six discrete decision-making processes that make success more likely while averting rash or unproductive behavior. These include setting attainable goals, tipping the power balance in your favor, weighing risks against benefits, and developing contingency plans. Goals may be organizational or personal. Tania Modic had both types in mind when, as a young bank manager, she overstepped her role by traveling to NewYork--on vacation time and on her own money--to revitalize some accounts that her senior colleagues had allowed to languish. Her high-risk maneuver benefited the bank and gained her a promotion. Lieutenant General Claudia J. Kennedy weighed the risks and benefits before deciding to report a fellow officer who had plagiarized a research paper at a professional army school. In her difficult courage calculation, loyalty to army standards proved stronger than the potential discomfort and embarrassment of "snitching" on a fellow officer. When the skills behind courageous decision making align with a personal, organizational, or societal philosophy, managers are empowered to make bold moves that lead to success for their companies and their careers.

  8. New treatment options for fibromyalgia: critical appraisal of duloxetine

    Directory of Open Access Journals (Sweden)

    Nurcan Üçeyler

    2008-06-01

    Full Text Available Nurcan Üçeyler1, Martin Offenbächer2, Frank Petzke3, Winfried Häuser4, Claudia Sommer11Department of Neurology, University of Würzburg, Germany; 2GRP – Generation Research Program, Human Science Center, University of Munich, Germany; 3Department of Anesthesiology, University of Cologne, Germany; 4Center of Pain Therapy, Klinikum Saarbrücken gGmbH, Winterberg 1, Saarbrücken, GermanyAbstract: Fibromyalgia syndrome (FMS is a chronic condition characterized by widespread pain, tender points, fatigue, and sleep disturbance. FMS leads to high disability levels, poor quality of life, and extensive use of medical care. Effective pharmacological treatment options are rare, and treatment effects are often of limited duration. Duloxetine is a new selective serotonin and norepinephrine reuptake inhibitor that is licensed for the treatment of pain in diabetic neuropathy. So far two randomized, placebo-controlled trials have investigated the short-term safety and efficacy of duloxetine 60 mg/day and 120 mg/day in patients suffering from FMS over a period of 12 weeks. Both dosages were superior to placebo in pain relief, and improvement in quality of life and depressive symptoms. The analgesic effect was largely independent of the antidepressant action of duloxetine. The higher dose of 120 mg/day further reduced the tender point count and elevated the tender point pain thresholds. Only mild to moderate adverse effects were reported. Duloxetine 60 mg/day and 120 mg/day has proven to be beneficial in the treatment of FMS symptoms. As true for other antidepressants further studies are needed to assess the long-term efficacy and safety of duloxetine as an additional pharmacological treatment option in FMS.Keywords: fibromyalgia syndrome, duloxetine, antidepressant, review, SNRI

  9. PDGF-metronidazole-encapsulated nanofibrous functional layers on collagen membrane promote alveolar ridge regeneration

    Directory of Open Access Journals (Sweden)

    Ho MH

    2017-08-01

    Full Text Available Ming-Hua Ho,1 Hao-Chieh Chang,2,3 Yu-Chia Chang,3 Jeiannete Claudia,1 Tzu-Chiao Lin,2 Po-Chun Chang2,3 1Department of Chemical Engineering, College of Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 2Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; 3Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan Abstract: This study aimed to develop a functionally graded membrane (FGM to prevent infection and promote tissue regeneration. Poly(L-lactide-co-D,L-lactide encapsulating platelet-derived growth factor (PDLLA-PDGF or metronidazole (PDLLA-MTZ was electrospun to form a nanofibrous layer on the inner or outer surface of a clinically available collagen membrane, respectively. The membrane was characterized for the morphology, molecule release profile, in vitro and in vivo biocompatibility, and preclinical efficiency for alveolar ridge regeneration. The PDLLA-MTZ and PDLLA-PDGF nanofibers were 800–900 nm in diameter, and the thicknesses of the functional layers were 20–30 µm, with sustained molecule release over 28 days. All of the membranes tested were compatible with cell survival in vitro and showed good tissue integration with minimal fibrous capsule formation or inflammation. Cell proliferation was especially prominent on the PDLLA-PDGF layer in vivo. On the alveolar ridge, all FGMs reduced wound dehiscence compared with the control collagen membrane, and the FGM with PDLLA-PDGF promoted osteogenesis significantly. In conclusion, the FGMs with PDLLA-PDGF and PDLLA-MTZ showed high biocompatibility and facilitated wound healing compared with conventional membrane, and the FGM with PDLLA-PDGF enhanced alveolar ridge regeneration in vivo. The design represents a beneficial modification, which may be easily adapted for future clinical use. Keywords: tissue engineering, platelet-derived growth factor, metronidazole, alveolar process

  10. Isothermal multiple displacement amplification: a methodical approach enhancing molecular routine diagnostics of microcarcinomas and small biopsies

    Directory of Open Access Journals (Sweden)

    Mairinger FD

    2014-08-01

    Full Text Available Fabian D Mairinger,1 Robert FH Walter,2 Claudia Vollbrecht,3 Thomas Hager,1 Karl Worm,1 Saskia Ting,1 Jeremias Wohlschläger,1 Paul Zarogoulidis,4 Konstantinos Zarogoulidis,4 Kurt W Schmid1 1Institute of Pathology, 2Ruhrlandklinik, West German Lung Center, University Hospital Essen, Essen, 3Institute of Pathology, University Hospital Cologne, Cologne, Germany; 4Pulmonary Department, Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece Background and methods: Isothermal multiple displacement amplification (IMDA can be a powerful tool in molecular routine diagnostics for homogeneous and sequence-independent whole-genome amplification of notably small tumor samples, eg, microcarcinomas and biopsies containing a small amount of tumor. Currently, this method is not well established in pathology laboratories. We designed a study to confirm the feasibility and convenience of this method for routine diagnostics with formalin-fixed, paraffin-embedded samples prepared by laser-capture microdissection. Results: A total of 250 µg DNA (concentration 5 µg/µL was generated by amplification over a period of 8 hours with a material input of approximately 25 cells, approximately equivalent to 175 pg of genomic DNA. In the generated DNA, a representation of all chromosomes could be shown and the presence of elected genes relevant for diagnosis in clinical samples could be proven. Mutational analysis of clinical samples could be performed without any difficulty and showed concordance with earlier diagnostic findings. Conclusion: We established the feasibility and convenience of IMDA for routine diagnostics. We also showed that small amounts of DNA, which were not analyzable with current molecular methods, could be sufficient for a wide field of applications in molecular routine diagnostics when they are preamplified with IMDA. Keywords: isothermal multiple displacement amplification, isothermal, whole

  11. C-fiber-related EEG-oscillations induced by laser radiant heat stimulation of capsaicin-treated skin

    Directory of Open Access Journals (Sweden)

    Claudia Domnick

    2009-03-01

    Full Text Available Claudia Domnick1, Michael Hauck1,2,3, Kenneth L Casey3, Andreas K Engel1, Jürgen Lorenz1,3,41Department of Neurophysiology and Pathophysiology; 2Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 3Department of Neurology, University of Michigan, Ann Arbor, MI, USA; 4Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, GermanyAbstract: Nociceptive input reaches the brain via two different types of nerve fibers, moderately fast A-delta and slowly conducting C-fibers, respectively. To explore their distinct roles in normal and inflammatory pain we used laser stimulation of normal and capsaicin treated skin at proximal and distal arm sites in combination with time frequency transformation of electroencephalography (EEG data. Comparison of phase-locked (evoked and non-phase-locked (total EEG to laser stimuli revealed three significant pain-related oscillatory responses. First, an evoked response in the delta-theta band, mediated by A-fibers, was reduced by topical capsaicin treatment. Second, a decrease of total power in the alpha-to-gamma band reflected both an A- and C-nociceptor-mediated response with only the latter being reduced by capsaicin treatment. Finally, an enhancement of total power in the upper beta band was mediated exclusively by C-nociceptors and appeared strongly augmented by capsaicin treatment. These findings suggest that phase-locking of brain activity to stimulus onset is a critical feature of A-delta nociceptive input, allowing rapid orientation to salient and potentially threatening events. In contrast, the subsequent C-nociceptive input exhibits clearly less phase coupling to the stimulus. It may primarily signal the tissue status allowing more long-term behavioral adaptations during ongoing inflammatory events that accompany tissue damage.Keywords: C-fibers, oscillations, EEG, laser, capsaicin, inflammatory pain

  12. User Acceptance of Computerized Cognitive Behavioral Therapy for Depression: Systematic Review.

    Science.gov (United States)

    Rost, Theresia; Stein, Janine; Löbner, Margrit; Kersting, Anette; Luck-Sikorski, Claudia; Riedel-Heller, Steffi G

    2017-09-13

    Computerized cognitive behavioral therapy (cCBT) has been proven to be effective in depression care. Moreover, cCBT packages are becoming increasingly popular. A central aspect concerning the take-up and success of any treatment is its user acceptance. The aim of this study was to update and expand on earlier work on user acceptance of cCBT for depression. This paper systematically reviewed quantitative and qualitative studies regarding the user acceptance of cCBT for depression. The initial search was conducted in January 2016 and involved the following databases: Web of Science, PubMed, the Cochrane Library, and PsycINFO. Studies were retained if they described the explicit examination of the user acceptance, experiences, or satisfaction related to a cCBT intervention, if they reported depression as a primary outcome, and if they were published in German or English from July 2007 onward. A total of 1736 studies were identified, of which 29 studies were eligible for review. User acceptance was operationalized and analyzed very heterogeneously. Eight studies reported a very high level of acceptance, 17 indicated a high level of acceptance, and one study showed a moderate level of acceptance. Two qualitative studies considered the positive and negative aspects concerning the user acceptance of cCBT. However, a substantial proportion of reviewed studies revealed several methodical shortcomings. In general, people experience cCBT for depression as predominantly positive, which supports the potential role of these innovative treatments. However, methodological challenges do exist in terms of defining user acceptance, clear operationalization of concepts, and measurement. ©Theresia Rost, Janine Stein, Margrit Löbner, Anette Kersting, Claudia Luck-Sikorski, Steffi G Riedel-Heller. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.09.2017.

  13. Targeted treatments for cervical cancer: a review

    Directory of Open Access Journals (Sweden)

    Peralta-Zaragoza O

    2012-11-01

    Full Text Available Oscar Peralta-Zaragoza,1 Víctor Hugo Bermúdez-Morales,1 Carlos Pérez-Plasencia,2,3 Jonathan Salazar-León,1 Claudia Gómez-Cerón,1 Vicente Madrid-Marina11Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Cuernavaca, Morelos, México; 2Oncogenomics Laboratory, National Cancer Institute of Mexico, Tlalpan, México; 3Biomedicine Unit, FES-Iztacala UNAM, México City, MéxicoAbstract: Cervical cancer is the second most common cause of cancer death in women worldwide and the development of new diagnosis, prognostic, and treatment strategies merits special attention. Although surgery and chemoradiotherapy can cure 80%–95% of women with early stage cancer, the recurrent and metastatic disease remains a major cause of cancer death. Many efforts have been made to design new drugs and develop gene therapies to treat cervical cancer. In recent decades, research on treatment strategies has proposed several options, including the role of HPV E6 and E7 oncogenes, which are retained and expressed in most cervical cancers and whose respective oncoproteins are critical to the induction and maintenance of the malignant phenotype. Other efforts have been focused on antitumor immunotherapy strategies. It is known that during the development of cervical cancer, a cascade of abnormal events is induced, including disruption of cellular cycle control, perturbation of antitumor immune response, alteration of gene expression, and deregulation of microRNA expression. Thus, in this review article we discuss potential targets for the treatment of cervical cancer associated with HPV infection, with special attention to immunotherapy approaches, clinical trials, siRNA molecules, and their implications as gene therapy strategies against cervical cancer development.Keywords: Cervical cancer, clinical trials, gene therapy, HPV E6 and E7 oncogenes, siRNAs

  14. Tinnitus: clinical experience of the psychosomatic connection

    Directory of Open Access Journals (Sweden)

    Salviati M

    2014-02-01

    Full Text Available Massimo Salviati,1 Francesco Saverio Bersani,1 Samira Terlizzi,1 Claudia Melcore,1 Roberta Panico,1 Graziella Francesca Romano,1 Guiseppe Valeriani,1 Francesco Macrì,1 Giancarlo Altissimi,2 Filippo Mazzei,2 Valeria Testugini,2 Luca Latini,1 Roberto Delle Chiaie,1 Massimo Biondi,1 Giancarlo Cianfrone21Department of Neurology and Psychiatry, Acute Psychiatric Ward (Servizio Psichiatrico di Diagnosi e Cura - SPDC, Sapienza University of Rome, Rome, Italy, 2Department of Sense Organs, Sapienza University of Rome, Rome, ItalyBackground: The connection between psychopathology and tinnitus is complex and not adequately studied. The aim of this study is to investigate the relationship between tinnitus and psychiatric comorbidities from different points of view: categorical, dimensional, temperamental, and perceived stress level.Methods: Two hundred and thirty-nine patients affected by tinnitus were recruited between January and October 2012. Patients underwent a preliminary battery of tests including the Tinnitus Handicap Inventory (THI, Symptom Check List (SCL90-R, Temperament and Character Inventory (TCI, and Stress-Related Vulnerability Scale (VRS, and eventually a full psychiatric evaluation. Results: One hundred and fourteen patients (48% of the total sample presented psychiatric comorbidity. Among these, a higher prevalence of depression, somatization, obsession, and anxiety was found. More than 41% of patients affected by decompensated tinnitus reported a family history of psychiatric disorders. Significant positive correlations between the psychopathological screening tools (SCL90-R and VRS and THI were found. Patients affected by comorbid psychiatric disorder showed specific temperamental and characterial predispositions.Conclusion: Psychiatric comorbidity in subjects affected by tinnitus is frequent. Stress can be considered as a factor leading to damage and dysfunction of the auditory apparatus. The vulnerability to neurotic disorders and

  15. Review: Manuela Boatca, Claudia Neudecker & Stefan Rinke (Eds. (2006. Des Fremden Freund, des Fremden Feind: Fremdverstehen in interdisziplinärer Perspektive [The Stranger's Friend, the Stranger's Enemy: Conceiving Foreignness in an Interdisciplinary Perspective

    Directory of Open Access Journals (Sweden)

    Claudia Brunner

    2007-09-01

    Full Text Available This book comprises the papers of a multidisciplinary workshop on the topic of foreignness/strangeness held at the Catholic University of Eichstätt, Germany, in July 2004. Seven authors try to critically question ways of conceiving foreignness instead of understanding or explaining it in the first place, doing so as a means of changing perspectives. The papers deal with the self-evidence of presumed Otherness and with aspects of constructing Otherness that appear to be strange indeed. A lengthy essay written by two of the editors rounds up the collection. The book is theoretically profound and politically ambitious, since both the workshop and the publication of its proceedings have an important aim: to develop an international and transcultural horizon of values for a common political and social agency based on multi- or interdisciplinary debates. The latter are conceived of as not only dealing with the objects of research, but with its subjects and with the multiple proceedings that lie behind the ways of getting to know the Other by constructing it. URN: urn:nbn:de:0114-fqs0703238

  16. Polymeric nanoparticles enhance the sonodynamic activity of meso-tetrakis (4-sulfonatophenyl porphyrin in an in vitro neuroblastoma model

    Directory of Open Access Journals (Sweden)

    Canaparo R

    2013-11-01

    Full Text Available Roberto Canaparo,1,* Greta Varchi,2,* Marco Ballestri,2 Federica Foglietta,1 Giovanna Sotgiu,2 Andrea Guerrini,2 Andrea Francovich,3 Pierluigi Civera,3 Roberto Frairia,4 Loredana Serpe1 1Department of Drug Science and Technology, University of Torino, Torino, Italy; 2Institute of the Organic Synthesis and Photoreactivity, National Research Council, Bologna, Italy; 3Departments of Electronics, Politecnico of Torino, Torino, Italy; 4Department of Medical Science, University of Torino, Torino, Italy *These authors contributed equally to this work Purpose: Sonodynamic therapy is a developing noninvasive modality for cancer treatment, based on the selective activation of a sonosensitizer agent by acoustic cavitation. The activated sonosensitizer agent might generate reactive oxygen species leading to cancer cell death. We investigated the potential poly-methyl methacrylate core-shell nanoparticles (NPs loaded with meso-tetrakis (4-sulfonatophenyl porphyrin (TPPS have to function as an innovative sonosensitizing system, ie, TPPS-NPs. Methods: Shockwaves (SWs generated by a piezoelectric device were used to induce acoustic cavitation. The cytotoxic effect of the sonodynamic treatment with TPPS-NPs and SWs was investigated on the human neuroblastoma cell line, SH-SY5Y. Cells were exposed for 12 hours to TPPS-NPs (100 µg/mL and then to SWs (0.43 mJ/mm2 for 500 impulses, 4 impulses/second. Treatment with SWs, TPPS and NPs alone or in combination was carried out as control. Results: There was a statistically significant decrease in SH-SY5Y cell proliferation after the sonodynamic treatment with TPPS-NPs and SWs. Indeed, there was a significant increase in necrotic (16.91% ± 3.89% and apoptotic (27.45% ± 3.03% cells at 48 hours. Moreover, a 15-fold increase in reactive oxygen species production for cells exposed to TPPS-NPs and SWs was observed at 1 hour compared with untreated cells. A statistically significant enhanced mRNA (messenger ribonucleic acid

  17. Generation of RNA in abiotic conditions.

    Science.gov (United States)

    di Mauro, Ernesto

    . Ciciriello, S. Pino, G. Costanzo, E. Di Mauro. From formamide to RNA: the roles of formamide and water in the evolution of chemical information. Research In Microbiology, Special Issue on The Origin of life and Microbiology (2009) 160:441-448. (2) Costanzo, G., Saladino, R., Crestini, C., Ciciriello, F., and Di Mauro, E. Nucleoside phos-phorylation by phosphate minerals. J. Biol. Chem. (2007) 282: 16729-16735. (3) Samanta Pino, Fabiana Ciciriello, Giovanna Costanzo and E. Di Mauro, Nonenzymatic RNA Ligation in Water J. Biol. Chem. (2008), 283: 36494-36503 (4) Costanzo, G., Pino, S., Ciciriello, F., and Di Mauro, E. Generation of long RNA chains in water. J Biol Chem. (2009) 284:33206-33216.

  18. INOVAÇÕES EM ALIMENTAÇÃO: AS PERCEPÇÕES DOS CONSUMIDORES SOBRE PRODUTOS ENRIQUECIDOS E TRANSGÊNICOS RESUMO

    Directory of Open Access Journals (Sweden)

    Thelma Lucchese Cheung

    2015-12-01

    Full Text Available Logo do cabeçalho da página AJUDA DO SISTEMA USUÁRIO Logado como: elvis MEUS PERIÓDICOS PERFIL SAIR DO SISTEMA CONTEÚDO DA REVISTA Pesquisa Escopo da Busca Pesquisar Procurar POR EDIÇÃO POR AUTOR POR TÍTULO OUTRAS REVISTAS TAMANHO DE FONTE MAKE FONT SIZE SMALLERMAKE FONT SIZE DEFAULTMAKE FONT SIZE LARGER INFORMAÇÕES PARA LEITORES PARA AUTORES PARA BIBLIOTECÁRIOS OPEN JOURNAL SYSTEMS CAPA SOBRE PÁGINA DO USUÁRIO PESQUISA ATUAL ANTERIORES NOTÍCIAS MESTRADO EM DESENVOLVIMENTO TERRITORIAL E SISTEMAS AGROINDUSTRIAIS BOAS PRÁTICAS DA PUBLICAÇÃO - ANPAD AVALIADORES 2012 AVALIADORES 2013 AVALIADORES 2014 AVALIADORES 2015 CAPA > V. 7, N. 4 (2015 >\tCHEUNG INOVAÇÕES EM ALIMENTAÇÃO: AS PERCEPÇÕES DOS CONSUMIDORES SOBRE PRODUTOS ENRIQUECIDOS E TRANSGÊNICOS RESUMO Thelma Lucchese Cheung, Claudia Macedo, Thiago Neves, Wellington da Silva Rodrigues Resumo Pretendeu-se neste artigo apresentar as percepções de um grupo de consumidores brasileiros em relação às inovações no setor de alimentos. Questionados sobre os alimentos transformados, geneticamente modificados e transgênicos que estão no mercado as opiniões dos indivíduos, cheias de valores e atitudes, permitiram a este estudo observar suas representações dessas inovações. O estudo que deu origem a este artigo é exploratório e qualitativo. Questões abertas de um questionário foram utilizadas para compreender as percepções da amostra sobre as inovações estudadas. As declarações de indivíduos adultos, de 20 a 40 anos, de ambos os gêneros e com alto nível de escolaridade e habitantes de diferentes estados brasileiros revelaram reações positivas quanto aos produtos modificados e transgênicos, associando-os com avanços da ciência e benefícios das descobertas científicas como alternativas de consumo conveniente e mais saudável.

  19. Multimetallic Systems for the Photocatalytic Production of Fuels from Abundant Sources

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, Kim; Turro, Claudia [The Ohio State University

    2018-04-01

    The reported findings herein are a result of a collaboration between the groups of Claudia Turro at The Ohio State University (DE-SC0010542) and Kim R. Dunbar at Texas A&M University (DE-SC0010721). The Turro and Dunbar groups jointly discovered that cationic d7–d7 Rh2(II,II) complexes bridged by electron-donating formamidinate (form) ligands possess redox-active excited states that are relatively long-lived and can engage in charge transfer reactions. As part of the present grant we designed new complexes that exhibit strong absorption from the UV to ~800 nm. The Rh2(II,II) complexes under investigation are poised to undergo catalytic reduction of substrates because they are robust to changes in metal oxidation state, the two metals and the two diimine ligands, together with the non-innocent bridges, can be used to store redox equivalents, making these complexes capable of coupling one-electron events with multi-electron transformations. We discovered the electrocatalytic reduction of H+ and CO2 by complexes that are able to electrocatalytically reduce H+ to H2 with high turnover frequencies (TOFs) and overpotentials, η, of ~0.5 V,8 as well as to reduce CO2 to HCOOH. We now have experimental evidence that both the production of H2 from H+ and HCOOH. The molecular catalysts are stable after the acid and/or CO2 is consumed since electrocatalysis is restored at the same rate upon the addition of substrate to the cell.8,9 Moreover, we showed that the catalysis is not a result of a decomposition product deposited on the electrode, since placing an electrode from an active electrocatalytic solution into one that does not contain catalyst completely shuts down the reactivity. We are currently exploring the reactivity of these complexes in hydride transfer reactions with other substrates and in the presence of CO2 and reducing agents, as well as attempting to grow single crystals for x-ray diffraction.

  20. Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

    Directory of Open Access Journals (Sweden)

    Tobar-Grande B

    2013-05-01

    Full Text Available Blanca Tobar-Grande,1 Ricardo Godoy,1 Paulina Bustos,2 Carlos von Plessing,1 Elias Fattal,3,4 Nicolas Tsapis,3,4 Claudia Olave,1 Carolina Gómez-Gaete11Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile; 2Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile; 3Univ Paris-Sud, Institut Galien Paris-Sud, Faculté de Pharmacie, Châtenay-Malabry, France; 4CNRS, UMR 8612, Faculté de Pharmacie, Châtenay-Malabry, FranceAbstract: In this work, microparticles were prepared by spray-drying using albumin, chondroitin sulfate, and hyaluronic acid as excipients to create a controlled-release methylprednisolone system for use in inflammatory disorders such as arthritis. Scanning electron microscopy demonstrated that these microparticles were almost spherical, with development of surface wrinkling as the methylprednisolone load in the formulation was increased. The methylprednisolone load also had a direct influence on the mean diameter and zeta potential of the microparticles. Interactions between formulation excipients and the active drug were evaluated by x-ray diffraction, differential scanning calorimetry, and thermal gravimetric analysis, showing limited amounts of methylprednisolone in a crystalline state in the loaded microparticles. The encapsulation efficiency of methylprednisolone was approximately 89% in all formulations. The rate of methylprednisolone release from the microparticles depended on the initial drug load in the formulation. In vitro cytotoxic evaluation using THP-1 cells showed that none of the formulations prepared triggered an inflammatory response on release of interleukin-1ß, nor did they affect cellular viability, except for the 9.1% methylprednisolone formulation, which was the maximum test concentration used. The microparticles developed in this study have characteristics amenable to a therapeutic role in

  1. Propagation Diagnostic Simulations Using High-Resolution Equatorial Plasma Bubble Simulations

    Science.gov (United States)

    Rino, C. L.; Carrano, C. S.; Yokoyama, T.

    2017-12-01

    In a recent paper, under review, equatorial-plasma-bubble (EPB) simulations were used to conduct a comparative analysis of the EPB spectra characteristics with high-resolution in-situ measurements from the C/NOFS satellite. EPB realizations sampled in planes perpendicular to magnetic field lines provided well-defined EPB structure at altitudes penetrating both high and low-density regions. The average C/NOFS structure in highly disturbed regions showed nearly identical two-component inverse-power-law spectral characteristics as the measured EPB structure. This paper describes the results of PWE simulations using the same two-dimensional cross-field EPB realizations. New Irregularity Parameter Estimation (IPE) diagnostics, which are based on two-dimensional equivalent-phase-screen theory [A theory of scintillation for two-component power law irregularity spectra: Overview and numerical results, by Charles Carrano and Charles Rino, DOI: 10.1002/2015RS005903], have been successfully applied to extract two-component inverse-power-law parameters from measured intensity spectra. The EPB simulations [Low and Midlatitude Ionospheric Plasma DensityIrregularities and Their Effects on Geomagnetic Field, by Tatsuhiro Yokoyama and Claudia Stolle, DOI 10.1007/s11214-016-0295-7] have sufficient resolution to populate the structure scales (tens of km to hundreds of meters) that cause strong scintillation at GPS frequencies. The simulations provide an ideal geometry whereby the ramifications of varying structure along the propagation path can be investigated. It is well known path-integrated one-dimensional spectra increase the one-dimensional index by one. The relation requires decorrelation along the propagation path. Correlated structure would be interpreted as stochastic total-electron-content (TEC). The simulations are performed with unmodified structure. Because the EPB structure is confined to the central region of the sample planes, edge effects are minimized. Consequently

  2. Vitamin D status and cholecalciferol supplementation in chronic kidney disease patients: an Italian cohort report

    Directory of Open Access Journals (Sweden)

    Cupisti A

    2015-11-01

    Full Text Available Adamasco Cupisti, Valentina Vigo, Maria Enrica Baronti, Claudia D'Alessandro, Lorenzo Ghiadoni, Maria Francesca Egidi Nephrology, Transplant and Dialysis Division, AOUP, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: This study investigated the factors associated with hypovitaminosis D, in a cohort of 405 prevalent patients with chronic kidney disease (CKD stages 2–4, living in Italy and followed-up in tertiary care. The effect of cholecalciferol 10,000 IU once-a-week for 12 months was evaluated in a subgroup of 100 consecutive patients with hypovitaminosis D. Vitamin D deficiency was observed in 269 patients (66.4% whereas vitamin D insufficiency was found in 67 patients (16.5%. In diabetic patients, 25-hydroxyvitamin D deficiency was detected in 80% of cases. In patients older than 65 years, the prevalence of hypovitaminosis D was 89%. In the univariate analysis, 25-hydroxyvitamin D was negatively related to age, parathyroid hormone (PTH, proteinuria, and Charlson index, while a positive relationship has emerged with hemoglobin level. On multiple regression analysis, only age and PTH levels were independently associated with 25-hydroxyvitamin D levels. No relationship emerged between vitamin D deficiency and renal function. Serum levels of 25-hydroxyvitamin D or prevalence of hypovitaminosis D did not differ between patients on a free-choice diet and on a renal diet, including low-protein, low-phosphorus regimens. Twelve-month oral cholecalciferol administration increased 25-hydroxyvitamin D and reduced PTH serum levels. In summary, hypovitaminosis D is very prevalent in CKD patients (83% in Italy, and it is similar to other locations. PTH serum levels and age, but not renal function, are the major correlates of hypovitaminosis D. Implementation of renal diets is not associated with higher risk of vitamin D depletion. Oral cholecalciferol administration increased 25-hydroxyvitamin D and mildly

  3. Holocene climate change in North Africa and the end of the African humid period - results of new high-resolution transient simulations with the MPI-ESM 1.3

    Science.gov (United States)

    Dallmeyer, Anne; Claussen, Martin; Lorenz, Stephan

    2017-04-01

    The Max-Planck-Institute for Meteorology has recently undertaken high-resolution transient Holocene simulations using the fully-coupled Earth System Model MPI-ESM 1.3. The simulations cover the last 8000 years and are forced not only by reconstructed Holocene orbital variations and atmospheric greenhouse gas concentrations, but also by recent compilations of Holocene volcanic aerosol distributions, variations in spectral solar irradiance, stratospheric ozone and land-use change. The simulations reveal the ubiquitous "Holocene conundrum": simulated global mean temperatures increase during the mid-Holocene and stay constant during the late Holocene. Simulated mid-Holocene near-surface temperatures are too cold in large parts of the world. Simulated precipitation, however, agrees much better with reconstruction than temperatures do. Likewise simulated global biome pattern fit reconstructions nicely, except for North Western America. First results of these simulations are presented with the main focus on the North African monsoon region. The amplitude of the mid-Holocene African Humid Period (AHP) is well captured in terms of precipitation and vegetation cover, so is the south-ward transgression of the termination of the AHP seen in reconstructions. The Holocene weakening and southward retreat of the North African monsoon as well as changes in the monsoon dynamic including shifts in the seasonal cycle and their relation to the locally varying termination of the AHP are discussed in detail. Members of the Hamburg Holocene Team: Jürgen Bader (1), Sebastian Bathiany (2), Victor Brovkin (1), Martin Claussen (1,3), Traute Crüger (1), Roberta D'agostino (1), Anne Dallmeyer (1), Sabine Egerer (1), Vivienne Groner (1), Matthias Heinze (1), Tatiana Ilyina (1), Johann Jungclaus (1), Thomas Kleinen (1), Alexander Lemburg (1), Stephan Lorenz (1), Thomas Raddatz (1), Hauke Schmidt (1), Gerhard Schmiedl (3), Bjorn Stevens (1), Claudia Timmreck (1), Matthew Toohey (4) (1) Max

  4. The StratusLab cloud distribution: Use-cases and support for scientific applications

    Science.gov (United States)

    Floros, E.

    2012-04-01

    The StratusLab project is integrating an open cloud software distribution that enables organizations to setup and provide their own private or public IaaS (Infrastructure as a Service) computing clouds. StratusLab distribution capitalizes on popular infrastructure virtualization solutions like KVM, the OpenNebula virtual machine manager, Claudia service manager and SlipStream deployment platform, which are further enhanced and expanded with additional components developed within the project. The StratusLab distribution covers the core aspects of a cloud IaaS architecture, namely Computing (life-cycle management of virtual machines), Storage, Appliance management and Networking. The resulting software stack provides a packaged turn-key solution for deploying cloud computing services. The cloud computing infrastructures deployed using StratusLab can support a wide range of scientific and business use cases. Grid computing has been the primary use case pursued by the project and for this reason the initial priority has been the support for the deployment and operation of fully virtualized production-level grid sites; a goal that has already been achieved by operating such a site as part of EGI's (European Grid Initiative) pan-european grid infrastructure. In this area the project is currently working to provide non-trivial capabilities like elastic and autonomic management of grid site resources. Although grid computing has been the motivating paradigm, StratusLab's cloud distribution can support a wider range of use cases. Towards this direction, we have developed and currently provide support for setting up general purpose computing solutions like Hadoop, MPI and Torque clusters. For what concerns scientific applications the project is collaborating closely with the Bioinformatics community in order to prepare VM appliances and deploy optimized services for bioinformatics applications. In a similar manner additional scientific disciplines like Earth Science can take

  5. “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD

    Directory of Open Access Journals (Sweden)

    Vogelmeier C

    2017-02-01

    Full Text Available Claus Vogelmeier,1 Heinrich Worth,2 Roland Buhl,3 Carl-Peter Criée,4 Nadine S Lossi,5 Claudia Mailänder,5 Peter Kardos6 1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL, Marburg, 2Facharzt Forum Fürth, Fürth, 3Pulmonary Department, Mainz University Hospital, Mainz, 4Department of Sleep and Respiratory Medicine, Evangelical Hospital Göttingen-Weende, Bovenden, 5Clinical Research, Respiratory, Novartis Pharma GmbH, Nürnberg, 6Group Practice and Centre for Allergy, Respiratory and Sleep Medicine, Red Cross Maingau Hospital, Frankfurt am Main, Germany Abstract: Many patients with chronic obstructive pulmonary disease (COPD receive inhaled corticosteroids (ICSs without a clear indication, and thus, the impact of ICS withdrawal on disease control is of great interest. DACCORD is a prospective, noninterventional 2-year study in the primary and secondary care throughout Germany. A subgroup of patients were taking ICS prior to entry – 1,022 patients continued to receive ICS for 2 years; physicians withdrew ICS on entry in 236 patients. Data from these two subgroups were analyzed to evaluate the impact of ICS withdrawal. Patients aged ≥40 years with COPD, initiating or changing COPD maintenance medication were recruited, excluding patients with asthma. Demographic and disease characteristics, prescribed COPD medication, COPD Assessment Test, exacerbations, and lung function were recorded. There were few differences in baseline characteristics; ICS withdrawn patients had shorter disease duration and better lung function, with 74.2% of ICS withdrawn patients not exacerbating, compared with 70.7% ICS-continued patients. During Year 1, exacerbation rates were 0.414 in the withdrawn group and 0.433 in the continued group. COPD Assessment Test total score improved from baseline in both groups. These data suggest

  6. Systemic effects of chronic obstructive pulmonary disease in young-old adults’ life-space mobility

    Directory of Open Access Journals (Sweden)

    Garcia IFF

    2017-09-01

    Full Text Available Isabel Fialho Fontenele Garcia,1 Carina Tiemi Tiuganji,1 Maria do Socorro Morais Pereira Simões,2 Ilka Lopes Santoro,3 Adriana Claudia Lunardi1,2 1Master’s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, 2Department of Physical Therapy, School of Medicine, University of Sao Paulo, 3Respiratory Division, Pulmonary Rehabilitation Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil Purpose: The objective was to assess whether dyspnea, peripheral muscle strength and the level of physical activity are correlated with life-space mobility of older adults with COPD.Patients and methods: Sixty patients over 60 years of age (40 in the COPD group and 20 in the control group were included. All patients were evaluated for lung function (spirometry, life-space mobility (University of Alabama at Birmingham Study of Aging Life-Space Assessment, dyspnea severity (Modified Dyspnea Index, peripheral muscle strength (handgrip dynamometer, level of physical activity and number of daily steps (accelerometry. Groups were compared using unpaired t-test. Pearson’s correlation was used to test the association between variables.Results: Life-space mobility (60.41±16.93 vs 71.07±16.28 points, dyspnea (8 [7–9] vs 11 [10–11] points, peripheral muscle strength (75.16±14.89 vs 75.50±15.13 mmHg, number of daily steps (4,865.4±2,193.3 vs 6,146.8±2,376.4 steps, and time spent in moderate to vigorous activity (197.27±146.47 vs 280.05±168.95 minutes were lower among COPD group compared to control group (p<0.05. The difference was associated with the lower mobility of COPD group in the neighborhood.Conclusion: Life-space mobility is decreased in young-old adults with COPD, especially at the neighborhood level. This impairment is associated to higher dyspnea, peripheral muscle weakness and the reduced level of physical activity. Keywords: COPD, elderly, mobility limitation, dyspnea, muscular

  7. Role of XPC, XPD, XRCC1, GSTP genetic polymorphisms and Barrett’s esophagus in a cohort of Italian subjects. A neural network analysis

    Directory of Open Access Journals (Sweden)

    Tarlarini C

    2012-08-01

    Full Text Available Claudia Tarlarini,1 Silvana Penco,1 Massimo Conio,2 Enzo Grossi3 On behalf of the Barrett Italian Study Group 1Department of Laboratory Medicine, Medical Genetics, Niguarda Ca’ Granda Hospital, Milan, Italy; 2Department of Gastroenterology, General Hospital, San Remo, Italy; 3Medical Department, Bracco Imaging SpA, Milan, ItalyBackground: Barrett’s esophagus (BE, a metaplastic premalignant disorder, represents the primary risk factor for the development of esophageal adenocarcinoma. Chronic gastroesophageal reflux disease and central obesity have been associated with BE and esophageal adenocarcinoma, but relatively little is known about the specific genes that confer susceptibility to BE carcinogenesis.Methods: A total of 74 patients with BE and 67 controls coming from six gastrointestinal Italian units were evaluated for six polymorphisms in four genes: XPC, XPD nucleotide excision repair (NER genes, XRCC1 (BER gene, and glutathione S-transferase P1. Smoking status was analyzed together with the genetic data. Statistical analysis was performed through Artificial Neural Networks.Results: Distributions of sex, smoking history, and polymorphisms among BE cases and controls did not show statistically significant differences. The r-value from linear correlation allowed us to identify possible protective factors as well as possible risk factors. The application of advanced intelligent systems allowed for the selection of a subgroup of nine variables. Artificial Neural Networks applied on the final data set reached mean global accuracy of 60%, reaching as high as 65.88%.Conclusion: We report here results from an exploratory study. Results from this study failed to find an association among the tested single nucleotide polymorphisms and BE phenotype through classical statistical methods. On the contrary, advanced intelligent systems are really able to handle the disease complexity, not treating the data with reductionist approaches unable to detect

  8. FAIRNESS 2016 [4. workshop for young scientists with research interests focused on physics at FAIR (Facility for Antiproton and Ion Research), Garmisch-Partenkirchen (Germany), 14-19 Feb 2016

    International Nuclear Information System (INIS)

    2016-01-01

    physics at FAIR. June 2016, Organizers of FAIRNESS 2016: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Claudia Ratti, and Laura Tolos. (paper)

  9. El subsuelo de la Torre del Pretorio: substructiones de tradición helenística bajo la sede del Concilium Prouinciae Hispaniae Citerioris (Tarraco

    Directory of Open Access Journals (Sweden)

    Serena Vinci, M.

    2014-12-01

    Full Text Available This paper presents the study of a complex architectonical area within the so-called provincial forum of Tarraco. The analysis of the architectonical stratigraphy and of the construction processes has been a fundamental tool to understand an area characterized by a complicated urban evolution, showing the development of the building project of such a vast construction as it is the provincial forum. Unfortunately, the absence of data provided by archaeological excavations limits the definition of a precise absolute chronology. The process of transforming the top of Tarraco’s hill into a monumental area started, according to historical and numismatic sources, during the Julio-Claudian era was completed in the Flavian one by ending this monumental complex distributed in three platforms. The area here analysed, placed close to the circus, belongs to a system of substructiones which commonly features those forum and sacred complexes organized in platforms at different levels.El artículo presenta el estudio de un área arquitectónicamente compleja, integrada dentro del denominado Foro Provincial de Tarraco. El análisis de la estratigrafía arquitectónica y de los procesos de construcción, ha representado un instrumento fundamental para la interpretación de un área caracterizada por una compleja evolución urbanística, poniendo en evidencia el desarrollo del proyecto constructivo de una obra de gran envergadura como la del Foro Provincial. Desafortunadamente, la ausencia de datos procedentes de las excavaciones arqueológicas, ha limitado la definición de una cronología absoluta exacta. El proceso de monumentalización de la cima de la colina tarraconense iniciado, según las fuentes históricas y numismáticas, en época julio-claudia, culminó en época Flavia con la finalización del complejo monumental distribuido en tres terrazas. El sector que se examina, situado junto al circo, se encuadra dentro de un sistema de substructiones que a

  10. Randomized controlled trial of a water-soluble nail lacquer based on hydroxypropyl-chitosan (HPCH, in the management of nail psoriasis

    Directory of Open Access Journals (Sweden)

    Cantoresi F

    2014-05-01

    Full Text Available Franca Cantoresi,1 Maurizio Caserini,2 Antonella Bidoli,1 Francesca Maggio,1 Raffaella Marino,1 Claudia Carnevale,1 Paola Sorgi,1 Renata Palmieri21Department of Dermatology, Sapienza University, Rome, Italy; 2Scientific Department, Polichem SA, Lugano, Switzerland Background: Nail psoriasis occurs in up to 50% of patients affected by psoriasis, with a significant impact on quality of life that leads to a real clinical need for new therapeutic options. Aim: To confirm whether the strengthening and hardening properties of the hydroxypropyl-chitosan (HPCH nail lacquer could improve the structure of the nail plates on psoriatic nails. Materials and methods: A randomized, double-blind, placebo controlled, parallel-group trial was carried out to evaluate the efficacy and tolerability of a hydrosoluble nail lacquer containing HPCH, Equisetum arvense, and methylsulfonylmethane on nail psoriasis. The test product or a placebo was applied once daily for 24 weeks to all fingernails. Efficacy assessments were performed on the target fingernail by means of the modified Nail Psoriasis Severity Index score. A cut-off score of 4 was considered to define the clinical cure rate (ie, Cure ≤4, Failure >4. Results: After 24 weeks, the clinical cure rate showed the statistically significant superiority of the HPCH nail lacquer compared to placebo in both the intention-to-treat (Fisher's exact test, P=0.0445 and the per protocol population (Fisher's exact test, P=0.0437. This superiority was already present after 16 weeks of treatment. Moreover, the analysis of the modified Nail Psoriasis Severity Index-50 showed a statistically significant clinical improvement after 12 weeks of treatment in comparison to the results obtained after 8 weeks (Fisher's exact test, P<0.05. Conclusion: The trial showed that HPCH nail lacquer could be a new, valid, effective, and safe option for decreasing the signs of nail dystrophy in psoriatic patients. Keywords: nail psoriasis

  11. Synthesis, characterization, and in vitro activity against Candida spp. of fluconazole encapsulated on cationic and conventional nanoparticles of poly(lactic-co-glycolic acid

    Directory of Open Access Journals (Sweden)

    Gómez-Sequeda N

    2017-05-01

    Full Text Available Nicolás Gómez-Sequeda,1 Rodrigo Torres,2 Claudia Ortiz3 1School of Biology, 2School of Chemistry, Faculty of Sciences, 3School of Microbiology, Faculty of Health, Universidad Industrial de Santander, Bucaramanga, Santander, Colombia Abstract: In this study, nanoparticles (NPs of poly(lactic-co-glycolic acid (PLGA loaded with fluconazole (FLZ and FLZ-NPs coated with the cationic polymer polyethylenimine (PEI (FLZ-NP-PEI were synthetized in order to improve antimycotic activity against four strains of Candida spp. of clinical relevance. FLZ-NPs and FLZ-NP-PEI were synthesized by double emulsion solvent-diffusion (DES-D and characterized. Minimum inhibitory concentration (MIC50 and minimum fungicide concentration (MFC were determined in vitro by culturing Candida strains in the presence of these nanocompounds. FLZ-NPs were spherical in shape with hydrodynamic sizes of ~222 nm and surface charge of -11.6 mV. The surface charges of these NPs were successfully modified using PEI (FLZ-NP-PEI with mean hydrodynamic sizes of 281 nm and surface charge of 23.5 mV. The efficiency of encapsulation (~53% and a quick release of FLZ (≥90% after 3 h were obtained. Cytotoxicity assay showed a good cell viability for FLZ-NPs (≥86%, and PEI-modified NPs presented a decrease in cell viability (~38%. FLZ-NPs showed an increasing antifungal activity of FLZ for sensitive (Candida parapsilosis ATCC22019 and Candida albicans ATCC10231, MIC50 =0.5 and 0.1 µg/mL, respectively and resistant strains (Candida glabrata EMLM14 and Candida krusei ATCC6258, MIC50 =0.1 and 0.5 µg/mL, respectively. FLZ-NP-PEI showed fungicidal activity even against C. glabrata and C. krusei (MFC =4 and 8 µg/mL, respectively. MIC50 values showed best results for FLZ-NPs and FLZ-NP-PEI. Nevertheless, only FLZ-NP-PEI displayed fungicidal activity against the studied strains. Keywords: drug delivery systems, double emulsion diffusion, nanoparticles, minimal inhibitory concentration

  12. Resenha do Livro: “Etnomatemática em movimento”-Gelsa Knijnik Fernanda Wanderer-Ieda M. Giongo- Claudia G. Duarte- Ed. Autêntica-Coleção Tendências em Educação Matemática, 2012

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Kistemann Jr.

    2013-03-01

    Full Text Available Nesta resenha apresentamos o mais novo livro da Coleção Tendências em Educação Matemática no qual as autoras retomam questões do pensamento etnomatemático, colocando-o em movimento, apoiando-se nos pensamentos dos filósofos Michel Foucault e Ludwig Wittgenstein para propor ideias e valorizar novas formulações visando à gênese de distintos modos de escolarização, além dos já reificados nas práticas escolares e curriculares, com base numa perspectiva etnomatemática abordada em diversos contextos, identificando os jogos de linguagem matemáticos, muitas vezes secundarizados ou marginalizados nas práticas pedagógicas em curso.

  13. Original article Unfulfilled parenthood in the eyes of young adults

    Directory of Open Access Journals (Sweden)

    Alicja Kalus

    2014-09-01

    Full Text Available Background The goal of the study was to present young adults’ perceptions of the experience of loss of a child at different stages of its prenatal development, as well as the level of declared support for couples after the loss. Participants and procedure The study used a scenario method based on the method by Claudia Lapman and Seana Dowling-Guyer (1995, translated into Polish by Joanna Szymańska (2013. One of the Berlin Social Support Scales (BSSS, Łyszczyńska, Kowalska, Mazurkiewicz, & Schwarzer, 2006 was also used. One hundred ninety two young adults (mean age = 26.76, SD = 4.64 took part in the research, mainly university students of technical subjects and humanities. Results The study showed that couples who lost their child, regardless of the stage at which it occurred (miscarriage or fetal death, were assessed more frequently as caring, loving, tender and sensitive, in comparison to couples for whom there was no mention of a child at all. Women who lost their child at a later stage (after the 22nd week of pregnancy were assessed significantly more frequently as relaxed, less lonely, calm and more self-confident than women who miscarried. The results were similar to those for women from the control scenario, where there was no mention of a child at all. In terms of declared support, the subjects declared significantly higher emotional support (expressing empathy, care, trust, intimacy, allowing for self-expression, etc. for couples who experienced the loss at a later stage of pregnancy than in the control scenario, as well as a higher level of instrumental support (providing material goods, solving difficult tasks together for couples who experienced miscarriage than the controls. Conclusions The experience of miscarriage and dealing with the loss is met with lower levels of empathy from the social environment, and, presumably, lower acceptance for grief. It seems important to sensitize people to the experiences of couples who

  14. SFEN Annual Convention 2012 - The nuclear energy one year after Fukushima. Proceedings; Convention SFEN 2012 - Le nucleaire un an apres Fukushima. Recueil des presentations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-03-15

    industry in France (Philippe Girault, PricewaterhouseCoopers); 21 - Public acceptance, different sectors, identical behaviours (Claudia Gross, Resosens); 22 - Conclusion (Dominique Miniere, SFEN); Additional presentations: 23 - The Fukushima Daichi accident (Peter Volkholz, Areva NP GmbH); 24 - Impact on the public and on the environment (Philippe Renaud, IRSN)

  15. Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients

    Directory of Open Access Journals (Sweden)

    Salgado PC

    2017-03-01

    Full Text Available Patricia C Salgado,1 Fabiana DV Genvigir,1 Claudia R Felipe,2 Helio Tedesco-Silva Jr,2 Jose O Medina-Pestana,2 Sonia Q Doi,3 Mario H Hirata,1 Rosario DC Hirata1 1Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, 2Division of Nephrology, Hospital do Rim, Federal University of Sao Paulo, Sao Paulo, Brazil; 3School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Background: The effects of genetic variants related to the pharmacodynamic mechanisms of immunosuppressive drugs on their therapeutic efficacy and safety have been poorly explored. This study was performed to investigate the influence of the PPP3CA c.249G>A variant on the clinical outcomes of kidney transplant recipients. Patients and methods: A total of 148 Brazilian patients received tacrolimus (TAC-based immunosuppressive therapy for 90 days post-kidney transplantation. The PPP3CA rs3730251 (c.249G>A polymorphism was determined by real-time polymerase chain reaction. Single-nucleotide polymorphism (SNP data for CYP3A5 rs776746 (CYP3A5*3C; g.6986A>G were used to eliminate the confounding effects of this variant. Results: The PPP3CA c.249G>A SNP did not influence early TAC exposure, renal function, or other laboratory parameters, including levels of urea, creatinine, glucose, and lipids, and blood counts. This variant also did not account for the cumulative incidence of biopsy-confirmed acute rejection or delayed graft function. Regarding adverse events, PPP3CA c.249A allele carriers initially had a 3.05-fold increased probability of treatment-induced blood and lymphatic system disorders compared with c.249GG genotype individuals (95% confidence interval: 1.10–8.48, p=0.032. However, this result was not maintained after adjusting for body weight and CYP3A5*3C SNP status (p=0.086. Conclusion: The PPP3CA c.249G>A variant does not influence the clinical outcomes of Brazilian patients in the

  16. Highly efficient and compatible shampoo for use after hair transplant

    Directory of Open Access Journals (Sweden)

    Schweiger D

    2015-07-01

    Full Text Available Dorothea Schweiger,1 Andrea M Schoelermann,1 Alexander Filbry,1 Tina Hamann,1 Claudia Moser,2 Frank Rippke1 1Research and Development, Beiersdorf AG, Hamburg, Germany; 2Moser Medical, Clinics for Aesthetic Plastic Surgery, Vienna, Austria Background: Sensitive or hyperreactive skin is a common condition defined by prickling, burning, pain, and pruritus. Although this skin problem was initially described on the face, the scalp is often affected. A sensitive scalp can react with irritation to harsh surfactants or other additives which are often present in shampoos. For this reason, we developed a new rinse-off hypertolerant shampoo specifically designed for the hypersensitive and problematic scalp.Methods: The shampoo formulation is based on an extremely mild surfactant system and contains bisabolol, an anti-irritant and anti-inflammatory ingredient of chamomile. The shampoo is free of additives such as perfumes, silicones, colorants, parabens, paraffins, and betaine. Since skin can remain in a hyperreactive state after wounding, the status after hair transplantation was chosen as a model system to test the shampoo. Scalp condition and compatibility of each volunteer were analyzed by a plastic surgeon directly after hair transplant and after stitch removal. The plastic surgeons also rated whether they would recommend the further use of the test shampoo. Additionally, volunteers completed a self-assessment questionnaire.Results: Following hair transplantation, regular use of the shampoo resulted in a significant reduction in the extent of scabbing and erythema. This was confirmed by dermatological scalp examinations performed by the plastic surgeon as well as in volunteers' self-assessments. The plastic surgeon highly recommended the further use of the test shampoo after hair transplant to all study participants.Conclusion: Application of the test shampoo demonstrated excellent skin compatibility and product efficacy after hair transplant. The test

  17. Nicoboxil/nonivamide cream effectively and safely reduces acute nonspecific low back pain – a randomized, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    Blahova Z

    2016-12-01

    Full Text Available Zuzana Blahova,1 Janina Claudia Holm,1 Thomas Weiser,2 Erika Richter,2 Matthias Trampisch,2 Elena Akarachkova3 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; 2Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; 3I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation Background/objective: Low back pain affects many patients and has a high socioeconomic impact. Topical capsaicinoids have been used for decades to treat musculoskeletal pain. This study investigated the effects of the fixed dose combination (FDC of nonivamide (a capsaicinoid and nicoboxil (a nicotinic acid ester cream in the treatment of acute nonspecific low back pain.Materials and methods: This phase III randomized, double-blind, placebo-controlled, multinational, multi-center trial investigated efficacy, safety, and tolerability of topical nicoboxil 1.08%/nonivamide 0.17% (Finalgon® cream in treatment of acute nonspecific low back pain with the endpoints: pain intensity (PI difference between pre-dose baseline and 8 hours after first application and the end of treatment, mobility score, and efficacy score.Results: Patients (n=138, 21–65 years of age, were treated for up to 4 days with FDC or placebo cream. Mean baseline PI was 6.8 on a 0–10 point numerical rating scale. After 8 hours, pain was more reduced with the FDC than with placebo (adjusted means: 2.824 vs. 0.975 points; p<0.0001. On the last treatment day, mean pain reduction by the FDC was stronger than with placebo (adjusted means: 5.132 vs. 2.174 points; p<0.0001. Mobility on Day 1 was in favor of the FDC when compared to placebo (odds ratio [95% confidence interval {CI}]: 7.200 [3.609, 14.363], p<0.0001. At the end of treatment, patients treated with the FDC rated efficacy significantly higher than placebo (odds ratio [95% CI]: 11.370 [5.342, 24.199], p<0.0001. Both treatments were tolerated well. No serious adverse events were reported.Conclusion: Nicoboxil

  18. Update on the role of eslicarbazepine acetate in the treatment of partial-onset epilepsy

    Directory of Open Access Journals (Sweden)

    Tambucci R

    2016-05-01

    Full Text Available Renato Tambucci,1 Claudia Basti,1 Maria Maresca,1 Giangennaro Coppola,2 Alberto Verrotti11Department of Pediatrics, University of L’Aquila, L’Aquila, Italy; 2Child and Adolescent Neuropsychiatry Unit, University of Salerno, Salerno, ItalyAbstract: Eslicarbazepine acetate (ESL is a once daily new third generation antiepileptic drug that shares the basic chemical structure of carbamazepine and oxcarbazepine – a dibenzazepine nucleus with the 5-carboxamide substituent, but is structurally different at the 10,11-position. ESL is a pro-drug metabolized to its major active metabolite eslicarbazepine. Despite the fact that the exact mechanism of action has not been fully elucidated, it is thought to involve inhibition of voltage-gated sodium channels (VGSC. ESL inhibits sodium currents in a voltage-dependent way by an interaction predominantly with the inactivated state of the VGSC, thus selectively reducing the activity of rapidly firing (epileptic neurons. ESL reduces VGSC availability through enhancement of slow inactivation. In Phase III studies, adjunctive therapy with ESL 800 or 1,200 mg/day leads to a significant decrease in the seizure frequency in adults with refractory partial onset epilepsy. Based on these results, ESL has been approved in Europe (by the European Medicines Agency and in the United States (by the US Food and Drug Administration as add-on therapy. Data on efficacy and safety have been confirmed by 1-year extension and real life observational studies. Recently, based on results from two randomized, double-blind, historical control Phase III trials, ESL received US Food and Drug Administration approval also as a monotherapy for patients with partial onset epilepsy. In the pediatric setting, encouraging results have been obtained suggesting its potential role in the management of epileptic children. Overall ESL was generally well tolerated. The most common adverse events were dizziness, somnolence, headache, nausea

  19. Contrast media-induced nephropathy: how has Italy contributed in the past 30 years? A systematic review

    Directory of Open Access Journals (Sweden)

    Sessa M

    2017-10-01

    Full Text Available Maurizio Sessa,1,* Claudia Rossi,2,* Annamaria Mascolo,1 Cristina Scavone,1 Gabriella di Mauro,1 Roberto Grassi,2 Liberata Sportiello,1 Salvatore Cappabianca,2 Concetta Rafaniello1 1Section of Pharmacology “L Donatelli”, Department of Experimental Medicine, University of Campania “L Vanvitelli”, Naples, Italy; 2Section of Radiology and Radiotherapy, Department of Clinical and Experimental Medicine “Magrassi-Lanzara”, University of Campania “L Vanvitelli”, Naples, Italy *These authors contributed equally to this work Background and objective: The use of contrast media in Italy has exponentially increased in the past 3 decades. However, it is unknown whether there has been an increase in clinical research evaluating the risks associated with contrast media usage, especially regarding contrast-induced nephropathy. To fill this gap in knowledge, we performed a systematic review.Study eligibility criteria: Meta-analyses, observational studies, and clinical trials assessing contrast media-induced nephropathy as the safety outcome, in which at least one author was affiliated with an Italian university/health care structure, were eligble.Data sources: Ovid MEDLINE, Ovid Embase, Cochrane Methodology Register, and Web of Science were screened.Participants: Men and women exposed to contrast media.Results: In total, 60 original articles were retrieved with an incremental trend between 1990 and 2017. Cohort studies were the most common study design represented. In total, 45 of 60 (75.0% studies were monocenter studies and 41 of 60 (68.3% received no funding. In all, 91.7% of studies disclosed no conflicts of interest and 81.7% had no external collaboration. Most of the studies provided a level of evidence of III-2 (32/60; 53.3% and II (23/60; 38.3%. In total, 50 of 60 studies (83.3% were published in a scientific journal ranked in the first quartile of their subject area.Conclusion: There was an increased number of studies evaluating

  20. The impact of anxiety and catastrophizing on interleukin-6 responses to acute painful stress

    Directory of Open Access Journals (Sweden)

    Lazaridou A

    2018-03-01

    Full Text Available Asimina Lazaridou,1 Marc O Martel,1 Christine M Cahalan,1 Marise C Cornelius,1 Olivia Franceschelli,1 Claudia M Campbell,2 Jennifer A Haythornthwaite,2 Michael Smith,2 Joseph Riley,3 Robert R Edwards1 1Department of Anesthesiology, Harvard Medical School, Brigham & Women’s Hospital, Boston, MA, USA; 2Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; 3Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL, USA Objective: To examine the influence of anxiety and pain-related catastrophizing on the time course of acute interleukin-6 (IL-6 responses to standardized noxious stimulation among patients with chronic pain.Methods: Data were collected from 48 participants in the following demographically matched groups: patients with chronic pain (n=36 and healthy controls (n=12. Participants underwent a series of Quantitative Sensory Testing (QST procedures assessing responses to mechanical and thermal stimuli during two separate visits, in a randomized order. One visit consisted of standard, moderately painful QST procedures, while the other visit involved nonpainful analogs to these testing procedures. Blood samples were taken at baseline, and then for up to 2 hours after QST in order to study the time course of IL-6 responses.Results: Results of multilevel analyses revealed that IL-6 responses increased across assessment time points in both visits (p<0.001. While patients with chronic pain and healthy controls did not differ in the magnitude of IL-6 responses, psychological factors influenced IL-6 trajectories only in the chronic pain group. Among patients, increases in catastrophizing over the course of the QST session were associated with elevated IL-6 responses only during the painful QST session (p<0.05. When controlling for anxiety, results indicated that the main multilevel model among patients remained significant

  1. Nanotechnology versus stem cell engineering: in vitro comparison of neurite inductive potentials

    Directory of Open Access Journals (Sweden)

    Morano M

    2014-11-01

    Full Text Available Michela Morano,1,* Sandra Wrobel,2,3,* Federica Fregnan,1 Ofra Ziv-Polat,4 Abraham Shahar,4 Andreas Ratzka,2 Claudia Grothe,2,3 Stefano Geuna,1 Kirsten Haastert-Talini2,3 1Department of Clinical and Biological Sciences, Università Degli Studi di Torino, Orbassano, Piemonte, Italy; 2Institute of Neuroanatomy, Hannover Medical School, Hannover, Lower-Saxony, Germany; 3Center for Systems Neuroscience (ZSN, Hannover, Lower-Saxony, Germany; 4NVR Research Ltd, Ness-Ziona, Israel *These authors contributed equally to this work and share first authorship Purpose: Innovative nerve conduits for peripheral nerve reconstruction are needed in order to specifically support peripheral nerve regeneration (PNR whenever nerve autotransplantation is not an option. Specific support of PNR could be achieved by neurotrophic factor delivery within the nerve conduits via nanotechnology or stem cell engineering and transplantation.Methods: Here, we comparatively investigated the bioactivity of selected neurotrophic factors conjugated to iron oxide nanoparticles (np-NTFs and of bone marrow-derived stem cells genetically engineered to overexpress those neurotrophic factors (NTF-BMSCs. The neurite outgrowth inductive activity was monitored in culture systems of adult and neonatal rat sensory dorsal root ganglion neurons as well as in the cell line from rat pheochromocytoma (PC-12 cell sympathetic culture model system.Results: We demonstrate that np-NTFs reliably support numeric neurite outgrowth in all utilized culture models. In some aspects, especially with regard to their long-term bioactivity, np-NTFs are even superior to free NTFs. Engineered NTF-BMSCs proved to be less effective in induction of sensory neurite outgrowth but demonstrated an increased bioactivity in the PC-12 cell culture system. In contrast, primary nontransfected BMSCs were as effective as np-NTFs in sensory neurite induction and demonstrated an impairment of neuronal differentiation in the PC-12

  2. Extreme QCD 2012 (xQCD)

    Science.gov (United States)

    2013-04-01

    Acknowledgements This conference would not have been possible without the generous support from Brookhaven National Laboratory and the George Washington University INS and IMPACT institutes, Columbian College of Arts and Sciences, the Office of Vice-President for Research, and the Department of Physics. We thank them wholeheartedly. We are also very grateful for the support of our colleagues on the local organizing committee, Walter Freeman and Frank Lee, and on the International Advisory Committee: Simon Hands, Tetsuo Hatsuda, Frithjof Karsch, Maria Paola Lombardo, Tereza Mendes, Atsushi Nakamura, Owe Philipsen, Claudia Ratti, Paul Romatschke, Misha Stephanov, and Nu Xu. List of participants Alexandru, Andrei George Washington University Bazavov, Alexei Brookhaven National Laboratory Bloch, Jacques University of Regensburg Braun-Munzinger, Peter EMMI, GSI Breto Rangel, Guillermo CMS/UC Davis D'Elia, Massimo University of Pisa, INFN Dexheimer, Veronica UFSC - Federal University of Santa Catarina Ding, Heng-Tong Brookhaven National Laboratory Dion, Alan Stony Brook University Dumitru, Adrian RBRC and Baruch College, CUNY Freeman, Walter George Washington University Gavai, Rajiv Tata Institute (TIFR), Mumbai Hanada, Masanori KEK Theory Center Hands, Simon Swansea University Hegde, Prasad Brookhaven National Laboratory Heinke, Craig University of Alberta Horvath, Ivan University of Kentucky Karsch, Frithjof Brookhaven National Laboratory Krieg, Stefan Wuppertal University Lattimer, James Stony Brook University Lee, Frank George Washington University Li, Anyi Institute for Nuclear Theory Liu, Keh-Fei University of Kentucky Lombardo, Maria Paola INFN - LNF Lottini, Stefano Goethe University, Frankfurt am Main Maezawa, Yu Brookhaven National Laboratory Miura, Kohtaroh Laboratori Nazionali di Frascati - INFN Monnai, Akihiko The University of Tokyo Mukherjee, Swagato Brookhaven National Laboratory Myers, Joyce University of Groningen Nakamura, Atsushi RIISE, Hiroshima

  3. The perspectives of older women with chronic neck pain on perceived effects of qigong and exercise therapy on aging: a qualitative interview study

    Directory of Open Access Journals (Sweden)

    Holmberg C

    2014-03-01

    Full Text Available Christine Holmberg,1,2 Julia Rappenecker,1 Julia J Karner,1 Claudia M Witt1,3 1Institute for Social Medicine, Epidemiology, and Health Economics, 2Berlin School of Public Health, Charité – Universitätsmedizin Berlin, Berlin, Germany; 3Center for Complementary and Integrative Medicine, University Hospital Zurich, Zurich, Switzerland Abstract: Chronic pain is prevalent in elderly populations. The goals of this study were 1 to understand the results of a randomized clinical trial – Qigong and Exercise Therapy for Elderly Patients with Chronic Neck Pain (QIBANE – that showed no difference between qigong, exercise therapy, and no-treatment on quality of life, and 2 to understand how elderly individuals with chronic pain experience interventions of qigong and exercise therapy. A qualitative interview study was conducted with 20 QIBANE participants. Interviews asked about motivation for and expectations of trial participation, experiences with the exercise classes (qigong or exercise therapy, and changes in pain experience. Interviews were transcribed, entered into the software program ATLAS.ti, and coded thematically by two coders. Content analysis was performed. All interviewees reflected positively on their QIBANE experience and described their participation in QIBANE as helpful. However, what was discussed in both groups when they talked about “positive experiences” in the study differed between the two groups. For example, themes that emerged in the exercise-therapy group related to difficulties associated with aging and staying physically active. In the interviews with qigong group members, emergent themes related to qigong as a method that improved bodily experiences and influenced daily activities. The effects that exercise therapy and qigong have on an elderly population cannot be captured by health-related quality-of-life measurements, such as the Short Form (36 Health Survey. Broader concepts of quality of life that include the

  4. For-profit colleges.

    Science.gov (United States)

    Deming, David; Goldin, Claudia; Katz, Lawrence

    2013-01-01

    For-profit, or proprietary, colleges are the fastest-growing postsecondary schools in the nation, enrolling a disproportionately high share of disadvantaged and minority students and those ill-prepared for college. Because these schools, many of them big national chains, derive most of their revenue from taxpayer-funded student financial aid, they are of interest to policy makers not only for the role they play in the higher education spectrum but also for the value they provide their students. In this article, David Deming, Claudia Goldin, and Lawrence Katz look at the students who attend for-profits, the reasons they choose these schools, and student outcomes on a number of broad measures and draw several conclusions. First, the authors write, the evidence shows that public community colleges may provide an equal or better education at lower cost than for-profits. But budget pressures mean that community colleges and other nonselective public institutions may not be able to meet the demand for higher education. Some students unable to get into desired courses and programs at public institutions may face only two alternatives: attendance at a for-profit or no postsecondary education at all. Second, for-profits appear to be at their best with well-defined programs of short duration that prepare students for a specific occupation. But for-profit completion rates, default rates, and labor market outcomes for students seeking associate's or higher degrees compare unfavorably with those of public postsecondary institutions. In principle, taxpayer investment in student aid should be accompanied by scrutiny concerning whether students complete their course of study and subsequently earn enough to justify the investment and pay back their student loans. Designing appropriate regulations to help students navigate the market for higher education has proven to be a challenge because of the great variation in student goals and types of programs. Ensuring that potential

  5. PREFACE: FAIRNESS 2014: FAIR Next Generation ScientistS 2014

    Science.gov (United States)

    2015-04-01

    is dedicated to the physics at FAIR. February 2015, Organizers of FAIRNESS 2014: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Conference photograph

  6. PREFACE: FAIRNESS 2013: FAIR NExt generation of ScientistS 2013

    Science.gov (United States)

    Petersen, Hannah; Destefanis, Marco; Galatyuk, Tetyana; Montes, Fernando; Nicmorus, Diana; Ratti, Claudia; Tolos, Laura; Vogel, Sascha

    2014-04-01

    research that is dedicated to the physics of FAIR. February 2014. Organizers of FAIRNESS 2013: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Hannah Petersen, Claudia Ratti, Laura Tolos, and Sascha Vogel. Support for holding the conference was provided by: Logos

  7. Bronchial hyperresponsiveness in women with chronic obstructive pulmonary disease related to wood smoke

    Directory of Open Access Journals (Sweden)

    Jaramillo C

    2012-06-01

    Full Text Available Mauricio González-García,1,2 Carlos A Torres-Duque,1,2 Adriana Bustos,1 Claudia Jaramillo,1 Darío Maldonado1,21Fundación Neumológica Colombiana, 2Universidad de la Sabana, Bogotá, ColombiaPurpose: Chronic obstructive pulmonary disease (COPD related to wood smoke exposure is characterized by important inflammation of the central and peripheral airways without significant emphysema. The objective of this study is to describe the bronchial hyperresponsiveness (BHR level in women with COPD related to wood smoke exposure and to compare it with the BHR in women with COPD related to tobacco smoking.Materials and methods: Two groups of women with stable COPD were studied: (1 wood smoke exposed (WS-COPD; and (2 tobacco smoke exposed (TS-COPD. A methacholine challenge test (MCT was performed in all patients according to American Thoracic Society criteria. BHR levels were compared using the methacholine concentration, which caused a 20% fall in the FEV1 (PC20.Results: Thirty-one patients, 19 with WS-COPD and 12 with TS-COPD, were included. There were no significant differences between the groups in baseline FVC, FEV1, IC, FEF25–75, and FEF25–75/FVC. All 31 patients had a positive MCT (PC20 , <16 mg/mL and the fall in the FEV1 and IC was similar in both groups. The severity of BHR was significantly higher in the WS-COPD patients (PC20: 0.39 mg/mL than in the TS-COPD patients (PC20: 1.24 mg/mL (P = 0.028. The presence of cough, phlegm, and dyspnea during the test were similar in both groups.Conclusion: We found moderate to severe BHR in women with WS-COPD, which was more severe than in the TS-COPD women with similar age and airflow obstruction. This paper suggests that the structural and inflammatory changes induced by the chronic exposure to wood smoke, described in other studies, can explain the differences with TS-COPD patients. Future studies may clarify our understanding of the impact of BHR on COPD physiopathology, phenotypes, and treatment

  8. SFEN Annual Convention 2012 - The nuclear energy one year after Fukushima. Proceedings

    International Nuclear Information System (INIS)

    2012-03-01

    France (Philippe Girault, PricewaterhouseCoopers); 21 - Public acceptance, different sectors, identical behaviours (Claudia Gross, Resosens); 22 - Conclusion (Dominique Miniere, SFEN); Additional presentations: 23 - The Fukushima Daichi accident (Peter Volkholz, Areva NP GmbH); 24 - Impact on the public and on the environment (Philippe Renaud, IRSN)

  9. "A combined experimental and individual-differences investigation into mind wandering during a video lecture": Correction to Kane et al. (2017).

    Science.gov (United States)

    2018-04-01

    Reports an error in "A combined experimental and individual-differences investigation into mind wandering during a video lecture" by Michael J. Kane, Bridget A. Smeekens, Claudia C. von Bastian, John H. Lurquin, Nicholas P. Carruth and Akira Miyake ( Journal of Experimental Psychology: General , 2017[Nov], Vol 146[11], 1649-1674). In the article, the legends for Figure 2 and Figure 4 were erroneous. The correct figures are included in the errata. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2017-48585-001.) A combined experimental-correlational study with a diverse sample (N = 182) from 2 research sites tested a set of 5 a priori hypotheses about mind wandering and learning, using a realistic video lecture on introductory statistics. Specifically, the study examined whether students' vulnerability to mind wandering during the lecture would predict learning from, and situational interest in, the video and also whether longhand note-taking would help reduce mind wandering, at least for some students. One half of the participants took notes during the video, and all were subsequently tested on lecture content without notes. Regression and mediation analyses indicated that (a) several individual-differences variables (e.g., pretest score, prior math interest, classroom media multitasking habits) uniquely predicted in-lecture mind wandering frequency; (b) although the note-taking manipulation did not reduce mind wandering at the group level, note-taking still reduced mind wandering for some individuals (i.e., those with lower prior knowledge and those who took notes of high quality and quantity); (c) mind wandering uniquely predicted both learning (posttest) and situational interest outcomes above and beyond all other individual-differences variables; (d) moreover, mind wandering significantly mediated the effects of several individual differences; and, finally, (e) not all types of mind

  10. Primera Jornada de Actualización en Patología Oral y Maxilofacial

    Directory of Open Access Journals (Sweden)

    Claudia Patricia Peña Vega

    2017-01-01

    Full Text Available Dedicamos las Lecturas recobradas a las memorias de la “Primera Jornada de Actualización en Patología Oral Y Maxilofacial” de las Facultades de Odontología y Medicina de la Universidad Nacional de Colombia, realizado en septiembre 30 al 01 de octubre del año 2016, bajo la coordinación de la profesora asociada del Departamento de Salud Oral de la universidad Nacional de Colombia, Claudia Patricia Peña Vega. El objetivo general del encuentro fue realizar una jornada académica integral de actualización en el campo de la Patología Oral y Maxilofacial dirigida a los estudiantes, residentes, egresados, profesores, y profesionales odontólogos, médicos, de las diferentes especialidades de interés en el área de la Patología General y Oral que fortalezcan la interdisciplinariedad del diagnóstico en un contexto clínico, académico e investigativo. Con el propósito de actualizar a los odontólogos y médicos en el estado del arte, avances tecnológicos y científicos en los diferentes campos de la Patología Oral y Maxilofacial, fortaleciendo académica y científicamente el campo de la Patología Oral y Maxilofacial, enmarcado como ámbito importante del conocimiento de la Patología General. Proporciona y difunde el Servicio de diagnóstico histopatológico en la Facultad de Odontología de la Universidad Nacional de Colombia. Todo esto, con el objetivo de crear un espacio académico para la presentación de casos clínicos y discusión de temas de interés, con la participación de diferentes expertos Patólogos de diferentes instituciones y creando nexos y vínculos académicos, hospitalarios y científicos con el Departamento de Patología de la Universidad Nacional de Colombia y la Sección Académica de Patología de la Faculta de Odontología de la Universidad Nacional de Colombia.

  11. Lymphangiopathy in neurofibromatosis 1 manifesting with chylothorax, pericardial effusion, and leg edema

    Directory of Open Access Journals (Sweden)

    Finsterer J

    2013-09-01

    Full Text Available Josef Finsterer,1 Claudia Stollberger,2 Elisabeth Stubenberger,3 Sasan Tschakoschian4 1Krankenanstalt Rudolfstiftung, Vienna, Austria; 2Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria; 3Thoracic Surgery Department, Vienna, Austria; 4Interne Lungenabt, Vienna, Austria Background: This case report documents the affliction of the lymph vessels as a phenotypic feature of neurofibromatosis-1 (NF-1. Methodology: Routine transthoracic echocardiography, computed tomography scan of the thorax, magnetic resonance angiography of the renal arteries, and conventional digital subtraction angiography were applied. Comprehensive NF-1 mutation analysis was carried out by fluorescence in situ hybridization analysis, long-range reverse transcriptase polymerase chain reaction, and multiple-ligation probe assay. All other investigations were performed using routine, well-established techniques. Results: The subject is a 34-year-old, half-Chinese male; NF-1 was suspected at age 15 years for the first time. His medical history included preterm birth, mild facial dysmorphism, "café au lait" spots, subcutaneous and paravertebral fibromas, multifocal tachycardia, atrial fibrillation, and heart failure in early infancy. Noncalcified bone fibromas in the femur and tibia were detected at age 8 years. Surgical right leg lengthening was carried out at age 11 years. Bilateral renal artery stenosis, stenosis and aneurysm of the superior mesenteric artery, and an infrarenal aortic stenosis were detected at age 15 years. Leg edema and ectasia of the basilar artery were diagnosed at age 18 years. After an episode with an erysipela at age 34 years, he developed pericardial and pleural effusion during a 4-month period. Stenosis of the left subclavian vein at the level of thoracic duct insertion was detected. After repeated pleural punctures, pleural effusion was interpreted as chylothorax. Reduction of lymph fluid production by diet and injection of talcum into

  12. An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial.

    Science.gov (United States)

    Raso, Giovanna; Essé, Clémence; Dongo, Kouassi; Ouattara, Mamadou; Zouzou, Fabien; Hürlimann, Eveline; Koffi, Veronique A; Coulibaly, Gaoussou; Mahan, Virginie; Yapi, Richard B; Koné, Siaka; Coulibaly, Jean Tenena; Meïté, Aboulaye; Guéhi-Kabran, Marie-Claire; Bonfoh, Bassirou; N'Goran, Eliézer Kouakou; Utzinger, Jürg

    2018-06-12

    chemotherapy, community-led total sanitation, and health education against infections with soil-transmitted helminths, schistosomes, an intestinal protozoa and prevention of diarrhea in a rural part of Côte d'Ivoire. The research provided new insights into the acceptability, strengths, and limitations of an integrated community-based control package targeting helminthiases, intestinal protozoa infections, and diarrhea in rural communities of Côte d'Ivoire. In the longer term, the study will allow determining the effect of the integrated control approach on infection patterns with parasitic worms and intestinal protozoa, diarrheal incidence, anthropometric measures, and hygiene-related knowledge, attitudes, practices, and beliefs. International Standard Randomized Controlled Trial Number (ISRCTN): 53102033; http://www.isrctn.com/ISRCTN53102033 (Archived by WebCite at http://www.webcitation.org/6wpnXEiHo). RR1-10.2196/9166. ©Giovanna Raso, Clémence Essé, Kouassi Dongo, Mamadou Ouattara, Fabien Zouzou, Eveline Hürlimann, Veronique A Koffi, Gaoussou Coulibaly, Virginie Mahan, Richard B Yapi, Siaka Koné, Jean Tenena Coulibaly, Aboulaye Meïté, Marie-Claire Guéhi-Kabran, Bassirou Bonfoh, Eliézer Kouakou N'Goran, Jürg Utzinger. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 12.06.2018.

  13. “They All Lived Happily Ever After. Obviously” : Realism and Utopia in Game of Thrones-Based Alternate Universe Fairy Tale Fan Fiction, Special Issue “Fairy Tale and its Uses in Contemporary New Media and Popular Culture,” Ed Claudia Schwabe

    NARCIS (Netherlands)

    Kustritz, A.M.

    2016-01-01

    Fan fiction alternate universe stories (AUs) that combine Game of Thrones characters and settings with fairy tale elements construct a dialogue between realism and wonder. Realism performs a number of functions in various genres, but becomes a particularly tricky concept to tie down in fantasy.

  14. Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: role of multimodal analysis

    Directory of Open Access Journals (Sweden)

    Bruè C

    2013-01-01

    Full Text Available Claudia Bruè, Andrea Saitta, Michele Nicolai, Cesare Mariotti, Alfonso GiovanniniOphthalmology, Department of Neuroscience, Marche Polytechnic University, Ancona, ItalyBackground: The purpose of this study was to evaluate the role of spectral domain optical coherence tomography (SD-OCT, MP-1 microperimetry, and fundus autofluorescence imaging for planning surgical procedures in combined hamartomas of the retina and retinal pigment epithelium (CHR-RPE and following epiretinal membrane removal.Methods: In an interventional retrospective case series, six consecutive subjects with CHR-RPE underwent vitrectomy and epiretinal membrane peeling, with 4 years of follow-up. Each underwent complete ophthalmic examination, including best corrected visual acuity, fundus examination, fundus fluorescein angiography, SD-OCT, MP-1, and fundus autofluorescence at one, 6, 12, and 48 months.Results: Six eyes from six subjects with CHR-RPE were studied (mean age 31 ± 14 years. All patients were phakic and five were male (83.3%. Lesions were unilateral, ie, three macular, two juxtapapillary and macular, and one pericentral. Preoperative best corrected visual acuity was 0.3 ± 0.08 Snellen, with significant improvement to 0.9 ± 0.17 Snellen (P = 0.001 at 4 years of follow-up. Mean retinal sensitivity within the central 20° field improved from 16.6 ± 1.84 dB to 18.8 ± 0.96 dB (P = 0.07. There was also a statistically significant reduction in the visual defect (P = 0.04. SD-OCT demonstrated that the epiretinal membranes were completely removed in all but one patient, with significantly decreased macular edema on follow-up at one, 6, 12, and 48 months (P = 0.001. A positive correlation was shown between preoperative macular sensitivity and postoperative best corrected visual acuity. Fundus autofluorescence demonstrated a block in background autofluorescence at the site of the lesion, and hyperautofluorescsence at the edematous retina overlain by the epiretinal

  15. Examining Motivations to Play Pokémon GO and Their Influence on Perceived Outcomes and Physical Activity.

    Science.gov (United States)

    Marquet, Oriol; Alberico, Claudia; Adlakha, Deepti; Hipp, J Aaron

    2017-10-24

    personal motivations and expectations when joining the game. These results highlight the importance of taking motivation into account when attempting to extract conclusions from the Pokémon GO phenomenon to enhance future exergames' designs or health interventions. ©Oriol Marquet, Claudia Alberico, Deepti Adlakha, J Aaron Hipp. Originally published in JMIR Serious Games (http://games.jmir.org), 24.10.2017.

  16. The Handbook of Medical Image Perception and Techniques

    Science.gov (United States)

    Samei, Ehsan; Krupinski, Elizabeth

    2014-07-01

    1. Medical image perception Ehsan Samei and Elizabeth Krupinski; Part I. Historical Reflections and Theoretical Foundations: 2. A short history of image perception in medical radiology Harold Kundel and Calvin Nodine; 3. Spatial vision research without noise Arthur Burgess; 4. Signal detection theory, a brief history Arthur Burgess; 5. Signal detection in radiology Arthur Burgess; 6. Lessons from dinners with the giants of modern image science Robert Wagner; Part II. Science of Image Perception: 7. Perceptual factors in reading medical images Elizabeth Krupinski; 8. Cognitive factors in reading medical images David Manning; 9. Satisfaction of search in traditional radiographic imaging Kevin Berbaum, Edmund Franken, Robert Caldwell and Kevin Schartz; 10. The role of expertise in radiologic image interpretation Calvin Nodine and Claudia Mello-Thoms; 11. A primer of image quality and its perceptual relevance Robert Saunders and Ehsan Samei; 12. Beyond the limitations of human vision Maria Petrou; Part III. Perception Metrology: 13. Logistical issues in designing perception experiments Ehsan Samei and Xiang Li; 14. ROC analysis: basic concepts and practical applications Georgia Tourassi; 15. Multi-reader ROC Steve Hillis; 16. Recent developments in FROC methodology Dev Chakraborty; 17. Observer models as a surrogate to perception experiments Craig Abbey and Miguel Eckstein; 18. Implementation of observer models Matthew Kupinski; Part IV. Decision Support and Computer Aided Detection: 19. CAD: an image perception perspective Maryellen Giger and Weijie Chen; 20. Common designs of CAD studies Yulei Jiang; 21. Perceptual effect of CAD in reading chest images Matthew Freedman and Teresa Osicka; 22. Perceptual issues in mammography and CAD Michael Ulissey; 23. How perceptual factors affect the use and accuracy of CAD for interpretation of CT images Ronald Summers; 24. CAD: risks and benefits for radiologists' decisions Eugenio Alberdi, Andrey Povyakalo, Lorenzo Strigini and

  17. Proceedings of the 19th ASPA Congress, Cremona, June 7-10, 2011

    Directory of Open Access Journals (Sweden)

    Guest Editor: Giacomo Pirlo

    2011-06-01

    Full Text Available The 19th Congress of the Animal Science and Production Association (ASPA, is held in the capital of one of the main European regions for animal production: Cremona. Despite its Gallic origin (Carra = rock, the name Cremona means big cream in modern Italian, in a clear allusion to milk. In this Congress, 153 oral presentations and 165 posters are presented, for a total of 318 scientific contributions. The Congress sessions with their relative number of papers are listed as follows: Animal breeding and genetics 87, Nutrition and feeding 57, Dairy production 40, Meat production 46, Animal welfare, Health and behaviour 37, Poultry and rabbit production 28 and Aquaculture 23. I would like to point out that 4 main lectures will be presented in the Animal breeding and genetics and Nutrition and feeding sessions (two in each, and that the Consiglio per la Ricerca in Agricoltura (Agricultural Research Council, the Agricultural Ministery research agency, which took charge of organizing the Congress, will award a prize for the best work here presented by young researchers. I would thank, first of all, Prof. Paolo Cescon, President of the Congress, for the contribution of all the CRA in organizing this event. I would also thank all the members of the Scientific Committee, dr. Riccardo Aleandri (President, dr. Fabio Abeni, dr. Fabiola Canavesi, dr. Giacinto Della Casa and dr. Marisanna Speroni, and of the Organizing Committee, dr. Giovanni Lo Piparo (President, dr. Stefania Barzaghi, dr. Maurizio Capelletti, dr. Giorgio Giraffa and dr. Luciano Migliorati. A special thanks to the secretary components, Maria Dissegna and Patrizia Re, assisted by Claudia Federici, Francesca Petrera, Miriam Odoardi, Maddalena Carli, Caterina Sanna, Stefania Marruso, Leonardo Boselli, Milena Rosi and Aldo Dal Prà. A special acknowlegment to Giacomo Pirlo, the real driving force organizing the Congress, a tireless and enthusiastic embroiderer of opportunities in scientific and

  18. Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury

    Directory of Open Access Journals (Sweden)

    Menk M

    2018-05-01

    Full Text Available Mario Menk, Jan Adriaan Graw, Clarissa von Haefen, Hendrik Steinkraus, Burkhard Lachmann, Claudia D Spies, David Schwaiberger Department of Anesthesiology and Operative Intensive Care Medicine, Charité – University Medicine Berlin, FreieUniversität Berlin, Humboldt-Universitätzu Berlin, and Berlin Institute of Health, Germany Purpose: Although the role of the angiotensin II type 2 (AT2 receptor in acute lung injury is not yet completely understood, a protective role of this receptor subtype has been suggested. We hypothesized that, in a rodent model of acute lung injury, stimulation of the AT2 receptor with the direct agonist Compound 21 (C21 might have a beneficial effect on pulmonary inflammation and might improve pulmonary gas exchange. Materials and methods: Male adult rats were divided into a treatment group that received pulmonary lavage followed by mechanical ventilation (LAV, n=9, a group receiving pulmonary lavage, mechanical ventilation, and direct stimulation of the AT2 receptor with C21 (LAV+C21, n=9, and a control group that received mechanical ventilation only (control, n=9. Arterial blood gas analysis was performed every 30 min throughout the 240-min observation period. Lung tissue and plasma samples were obtained at 240 min after the start of mechanical ventilation. Protein content and surface activity of bronchoalveolar lavage fluid were assessed and the wet/dry-weight ratio of lungs was determined. Transcriptional and translational regulation of pro- and antiinflammatory cytokines IL-1β, tumor necrosis factor-alpha, IL-6, IL-10, and IL-4 was determined in lungs and in plasma. Results: Pulmonary lavage led to a significant impairment of gas exchange, the formation of lung edema, and the induction of pulmonary inflammation. Protein content of lavage fluid was increased and contained washed-out surfactant. Direct AT2 receptor stimulation with C21 led to a significant inhibition of tumor necrosis factor-alpha and IL-6

  19. Ver, Compreender e Aprender: estudo comparado com guias de uso de apps editoriais para dispositivos móveis

    Directory of Open Access Journals (Sweden)

    Ana Claudia Dalagnoli

    2016-12-01

    Full Text Available Este estudo foi construído a partir da percepção de que a evolução das tecnologias e, sobretudo, o aprimoramento da comunicação em dispositivos móveis, impacta diretamente no processo de desenvolvimento de aplicativos (apps e softwares e na relação do ser humano com as novas interfaces. A pesquisa apresenta uma análise comparativa entre os aplicativos para iPad das revistas de decoração e design de interiores Casa Claudia (Editora Abril e Casa e Jardim (Editora Globo, a partir de testes de usabilidade dos mesmos em tablets Apple. O objetivo foi verificar se os guias de uso disponíveis em aplicativos (apps de revistas para dispositivos móveis, construídos por textos e imagens, estão cumprindo a função de comunicar, efetivamente, o modo de uso desses apps. As informações foram coletadas junto a mulheres com idade entre 25 e 54 anos que testaram e comentaram o funcionamento das versões atuais dos apps. Foram selecionadas 24 mulheres para fazerem atividades individuais monitoradas em ambos os apps, com dados coletados por meio de observações e think aloud. Os dados obtidos foram analisados, e com base nos resultados foi proposto um ajuste nos requisitos para o desenvolvimento de interfaces de guias para aplicativos com vistas à maior satisfação das usuárias. Foram percebidas falhas severas na apreensão e aplicação das orientações disponíveis nos guias de uso. Os pesquisadores verificaram que os requisitos básicos para aumentar a satisfação e melhorar a usabilidade estão relacionados à facilidade de compreensão e à simplicidade no uso, o que pode ser obtido por meio de melhorias relacionadas à aplicação da tecnologia, ao conhecimento dos processos cognitivos dos usuários e à aplicação de conceitos semióticos de comunicação. O estudo pode servir de base para o desenvolvimento e análise de guias de uso de outros apps com características similares, em diversos sistemas operacionais.

  20. Effects and feasibility of an Integrative Medicine program for geriatric patients– a cluster-randomized pilot study

    Directory of Open Access Journals (Sweden)

    Teut M

    2013-07-01

    Full Text Available Michael Teut, Katharina Schnabel, Roland Baur, Annette Kerckhoff, Frauke Reese, Niels Pilgram, Franziska Berger, Rainer Luedtke, Claudia M Witt Institute for Social Medicine, Epidemiology and Health Economics, Charité – Universitätsmedizin Berlin, Berlin, Germany Background: Older adults often use complementary medicine; however, very few interventional studies have focused on them. The aim of this study was to evaluate the feasibility and to obtain preliminary data on effectiveness of an Integrative Medicine (IM program compared to usual medical care. Methods: The study consisted of older adults living in shared apartment communities including caregiving. The shared apartments were cluster-randomized to the IM program or Usual Care (UC. IM consisted of additional lifestyle modification (exercise and diet, external naturopathic applications, homeopathic treatment, and modification of conventional drug therapy for 12 months. The UC group received conventional care alone. The following outcomes were used: Nurses Observation Scale for Geriatric Patients (NOSGER; Assessment of Motor and Process Skills; Barthel Index; Qualidem; Profile of Wellbeing; and Mini-mental State Examination. Exploratory effect sizes (Cohen’s d, means adjusted for differences of baseline values were calculated to analyze group differences. Results: A total of eight shared apartment communities were included; four were allocated to IM (29 patients, median seven patients; [mean ± standard deviation] 82.7 ± 8.6 years and four to UC (29 patients, median eight patients; 76.0 ± 12.8 years of age. After 12 months, effect sizes ≥0.3 were observed for activities of daily living on the NOSGER-Activities of Daily Living subscale (0.53, Barthel Index (0.30, Qualidem total sum score (0.39, Profile of Wellbeing (0.36, NOSGER-Impaired Social Behavior (0.47, and NOSGER-Depressed Mood subscales (0.40. Smaller or no effects were observed for all other outcomes. The intervention

  1. Wearable cardioverter defibrillators for the prevention of sudden cardiac arrest: a health technology assessment and patient focus group study

    Directory of Open Access Journals (Sweden)

    Ettinger S

    2017-11-01

    Full Text Available Sabine Ettinger,1 Michal Stanak,1 Piotr Szymański,2 Claudia Wild,1 Romana Tandara Haček,3 Darija Erčević,3 Renata Grenković,3 Mirjana Huić3 1Ludwig Boltzmann Institute for Health Technology Assessment, Vienna, Austria; 2Institute of Cardiology, Warsaw, Poland; 3Department for Development, Research and Health Technology Assessment, Agency for Quality and Accreditation in Health Care and Social Welfare, Zagreb, Croatia Aim: To summarize the evidence on clinical effectiveness and safety of wearable cardioverter defibrillator (WCD therapy for primary and secondary prevention of sudden cardiac arrest in patients at risk. Methods: We performed a systematic literature search in databases including MEDLINE via OVID, Embase, the Cochrane Library, and CRD (DARE, NHS-EED, HTA. The evidence obtained was summarized according to GRADE methodology. A health technology assessment (HTA was conducted using the HTA Core Model® for rapid relative effectiveness assessment. Primary outcomes for the clinical effectiveness domain were all-cause and disease-specific mortality. Outcomes for the safety domain were adverse events (AEs and serious adverse events (SAEs. A focus group with cardiac disease patients was conducted to evaluate ethical, organizational, patient, social, and legal aspects of the WCD use. Results: No randomized- or non-randomized controlled trials were identified. Non-comparative studies (n=5 reported AEs including skin rash/itching (6%, false alarms (14%, and palpitations/light-headedness/fainting (9% and discontinuation due to comfort/lifestyle issues (16–22%, and SAEs including inappropriate shocks (0–2%, unsuccessful shocks (0–0.7%, and death (0–0.3%. The focus group results reported that experiencing a sense of security is crucial to patients and that the WCD is not considered an option for weeks or even months due to expected restrictions in living a “normal” life. Conclusion: The WCD appears to be relatively safe for short

  2. Preferences of patients undergoing hemodialysis – results from a questionnaire-based study with 4,518 patients

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    Janssen IM

    2015-06-01

    Full Text Available Inger Miriam Janssen,1 Ansgar Gerhardus,2,3 Gero D von Gersdorff,4 Conrad August Baldamus,4 Mathias Schaller,4 Claudia Barth,5 Fueloep Scheibler6 1Department of Epidemiology and International Public Health, Bielefeld University, Bielefeld, Germany; 2Department for Health Services Research, University of Bremen, Bremen, Germany; 3Health Sciences Bremen, University of Bremen, Bremen, Germany; 4Department of Internal Medicine II, University Hospital of Cologne, Cologne, Germany; 5KfH Kuratorium fuer Dialyse und Nierentransplantation e.V., Neu-Isenburg, Germany; 6Department of Non-Drug Interventions, Institute for Quality and Efficiency in Health Care, Cologne, Germany Background: Chronic kidney disease is an increasing health problem worldwide and in its final stage (stage V can only be treated by renal replacement therapy, mostly hemodialysis. Hemodialysis has a major influence on the everyday life of patients and many patients report dissatisfaction with treatment. Little is known about which aspects of treatment are considered important by hemodialysis patients. The objective of this study was to rate the relative importance of different outcomes for hemodialysis patients and to analyze whether the relative importance differed among subgroups of patients.Patients and methods: Within the framework of a yearly questionnaire which is distributed among patients receiving hemodialysis by the largest hemodialysis provider in Germany, we assessed the relative importance of 23 outcomes as rated on a discrete visual analog scale. Descriptive statistics were used to rank the outcomes. Subgroup analyses were performed using Mann–Whitney U or Kruskal–Wallis tests.Results: Questionnaires of 4,518 hemodialysis patients were included in the analysis. The three most important outcomes were safety of treatment, health-related quality of life, and satisfaction with care. Further important outcomes were hospital stays, accompanying symptoms, hemodialysis

  3. Extubation process in bed-ridden elderly intensive care patients receiving inspiratory muscle training: a randomized clinical trial

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    Cader SA

    2012-10-01

    Full Text Available Samária Ali Cader,1 Rodrigo Gomes de Souza Vale,1 Victor Emmanuel Zamora,2 Claudia Henrique Costa,2 Estélio Henrique Martin Dantas11Laboratory of Human Kinetics Bioscience, Federal University of Rio de Janeiro State, 2Pedro Ernesto University Hospital, School of Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilBackground: The purpose of this study was to evaluate the extubation process in bed-ridden elderly intensive care patients receiving inspiratory muscle training (IMT and identify predictors of successful weaning.Methods: Twenty-eight elderly intubated patients in an intensive care unit were randomly assigned to an experimental group (n = 14 that received conventional physiotherapy plus IMT with a Threshold IMT® device or to a control group (n = 14 that received only conventional physiotherapy. The experimental protocol for muscle training consisted of an initial load of 30% maximum inspiratory pressure, which was increased by 10% daily. The training was administered for 5 minutes, twice daily, 7 days a week, with supplemental oxygen from the beginning of weaning until extubation. Successful extubation was defined by the ventilation time measurement with noninvasive positive pressure. A vacuum manometer was used for measurement of maximum inspiratory pressure, and the patients' Tobin index values were measured using a ventilometer.Results: The maximum inspiratory pressure increased significantly (by 7 cm H2O, 95% confidence interval [CI] 4–10, and the Tobin index decreased significantly (by 16 breaths/min/L, 95% CI −26 to 6 in the experimental group compared with the control group. The Chi-squared distribution did not indicate a significant difference in weaning success between the groups (Χ2 = 1.47; P = 0.20. However, a comparison of noninvasive positive pressure time dependence indicated a significantly lower value for the experimental group (P = 0.0001; 95% CI 13.08–18.06. The receiver

  4. Anthroposophic therapy for attention deficit hyperactivity: A two-year prospective study in outpatients

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    Harald J Hamre

    2010-08-01

    Full Text Available Harald J Hamre1, Claudia M Witt2, Gunver S Kienle1, Christoph Meinecke3, Anja Glockmann1, Renatus Ziegler4, Stefan N Willich2, Helmut Kiene11Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany; 2Institute of Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, Germany; 3Pediatric Consultant, Community Hospital Havelhöhe, Berlin, Germany; 4Society for Cancer Research, Arlesheim, SwitzerlandBackground: Anthroposophic treatment for attention deficit hyperactivity disorder (ADHD includes special artistic and physical therapies and special medications.Methods: We studied 61 consecutive children starting anthroposophic treatment for ADHD symptoms under routine outpatient conditions. Primary outcome was FBB-HKS (a parents’ questionnaire for ADHD core symptoms, 0–3, and secondary outcomes were disease and symptom scores (physicians’ and parents’ assessment, 0–10 and quality of life (KINDL® total score, 0–100.Results: A total of 67% of patients fulfilled the DSM-IV criteria for ADHD, 15% had an exclusion diagnosis such as pervasive developmental disorders, while 18% did not fulfill ADHD criteria for another reason. Anthroposophic treatment modalities used were eurythmy therapy (in 56% of patients, art therapy (20%, rhythmical massage therapy (8%, and medications (51%. From baseline to six-month follow-up, all outcomes improved significantly; average improvements were FBB-HKS total score 0.30 points (95% confidence interval [CI]: 0.18–0.43; P < 0.001, FBB-HKS inattention 0.36 (95% CI: 0.21–0.50; P < 0.001, FBB-HKS hyperactivity 0.29 (95% CI: 0.14–0.44; P < 0.001, FBB-HKS impulsivity 0.22 (95% CI: 0.03–0.40; P < 0.001, disease score 2.33 (95% CI: 1.84–2.82; P < 0.001, symptom score 1.66 (95% CI: 1.17–2.16; P < 0.001, and KINDL 5.37 (95% CI: 2.27–8.47; P = 0.001. Improvements were similar in patients not using stimulants (90% of patients at months 0–6 and

  5. Cardiotoxic effects of the novel approved anti-ErbB2 agents and reverse cardioprotective effects of ranolazine

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    De Lorenzo C

    2018-04-01

    Full Text Available Claudia De Lorenzo,1,2,* Rolando Paciello,1,2,* Gennaro Riccio,3 Domenica Rea,4 Antonio Barbieri,4 Carmela Coppola,4 Nicola Maurea4 1Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Naples, Italy; 2Ceinge, Biotecnologie Avanzate s.c.a.r.l., Naples, Italy; 3Department of Pharmacy, Federico II University, Naples, Italy; 4Division of Cardiology, Istituto Nazionale Tumori – Irccs Fondazione G. Pascale, Naples, Italy *These authors contributed equally to this work Purpose: Pertuzumab, a novel anti-epidermal growth factor receptor 2 humanized monoclonal antibody, and trastuzumab-emtansine (TDM1, a novel antibody–drug conjugate made up of trastuzumab covalently linked to the highly potent microtubule inhibitory agent DM1, have been recently approved by the US Food and Drug Administration for increasing the efficiency and safety of breast cancer therapy with trastuzumab. We investigated for the first time the potential cardiotoxic effects of pertuzumab and TDM1, which are not yet fully elucidated, and we tested whether ranolazine could blunt their cardiotoxicity.Methods: The cardiotoxic effects were tested in vitro on rat cardiomyoblasts, human fetal cardiomyocytes, adult-like cardiomyocytes, and in vivo on a mouse model.Results: All the treated cardiac cell lines were significantly affected by treatment with the tested drugs. Surprisingly, TDM1 showed stronger inhibitory effects on cardiac cells with respect to trastuzumab and pertuzumab by more significantly reducing the cell viability and by changing the morphology of these cells. TDM1 also affected the beating phenotype of adult-like cardiomyocytes in vitro and reduced fractional shortening and ejection fraction in vivo in a mouse model. We also found that ranolazine attenuated not only the cardiotoxic side effects of trastuzumab but also those of pertuzumab and TDM1, when used in combinatorial treatments both in vitro and in vivo, as

  6. Implementation of the Blended Care Self-Management Program for Caregivers of People With Early-Stage Dementia (Partner in Balance): Process Evaluation of a Randomized Controlled Trial.

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    Boots, Lizzy Mm; de Vugt, Marjolein E; Smeets, Claudia Mj; Kempen, Gertrudis Ijm; Verhey, Frans Rj

    2017-12-19

    , time, and deviating target population. Participants and coaches were satisfied with the intervention, but adapting the content to specific subgroups, for example, younger caregivers, was recommended. Implementation of the program requires more awareness of the benefits of blended care self-management programs and training in tailored self-management skills. Dutch Trial Register (NTR): NTR4748; http://www.trialregister.nl (Archived by WebCite at http://www.webcitation.org/6vSb2t9Mg). ©Lizzy MM Boots, Marjolein E de Vugt, Claudia MJ Smeets, Gertrudis IJM Kempen, Frans RJ Verhey. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.12.2017.

  7. Preliminary pediatric clinical evaluation of the oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes and recurrent acute otitis media

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    Di Pierro F

    2012-11-01

    Full Text Available Francesco Di Pierro,1 Guido Donato,2 Federico Fomia,3 Teresa Adami,4 Domenico Careddu,5 Claudia Cassandro,6 Roberto Albera61Scientific Department, Velleja Research, Milano, 2ASL 1, Cuneo, 3ASL 3, Brescia, 4Infective Diseases, Verona, 5ASL 13, Novara, 6Surgical Science Department, Università degli Studi, Torino, ItalyBackground: The oral probiotic Streptococcus salivarius K12 has been shown clearly to antagonize the growth of Streptococcus pyogenes, the most important bacterial cause of pharyngeal infections in humans, by releasing two bacteriocins named salivaricin A2 and salivaricin B. Unpublished observations indicate that it can also antagonize the growth of other bacteria involved in acute otitis media. Because of its ability to colonize the oral cavity and its safety profile, we have tested its efficacy in reducing the incidence of streptococcal pharyngitis and/or tonsillitis and episodes of acute otitis media.Methods: We enrolled 82 children, including 65 with and 17 without a recent diagnosis of recurrent oral streptococcal pathology. Of those with recurrent pathology, 45 were treated daily for 90 days with an oral slow-release tablet containing five billion colony-forming units of S. salivarius K12 (Bactoblis®, and the remaining 20 served as an untreated control group. The 17 children without a recent diagnosis of recurrent oral pathology were used as an additional control group. After 90 days of treatment, a 6-month follow-up period without treatment was included to evaluate a possible persistent protective role for the previously administered product.Results: The 41 children who completed the 90-day course of Bactoblis showed a reduction in their episodes of streptococcal pharyngeal infection (about 90% and/or acute otitis media (about 40%, calculated by comparing infection rates in the previous year. The 90-day treatment also reduced the reported incidence of pharyngeal and ear infections by about 65% in the 6-month follow-up period

  8. Spreading improvements for advanced COPD care through a Canadian Collaborative

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    Rocker GM

    2017-07-01

    Full Text Available Graeme M Rocker,1 Claudia Amar,2 Wendy L Laframboise,3 Jane Burns,4 Jennifer Y Verma2 1Division of Respirology, Nova Scotia Health Authority/Dalhousie University, Halifax, NS, 2Canadian Foundation for Healthcare Improvement, 3The Ottawa Hospital COPD Outreach Program, Ottawa, ON, 4Providence COPD Outreach Program, Vancouver, BC, Canada Background: A year-long pan-Canadian quality improvement collaborative (QIC led by the Canadian Foundation for Healthcare Improvement (CFHI supported the spread of the successful Halifax, Nova Scotia-based INSPIRED COPD Outreach Program™ to 19 teams in the 10 Canadian provinces. We describe QIC results, addressing two main questions: 1 Can the results of the Nova Scotia INSPIRED model be replicated elsewhere in Canada? 2 How did the teams implement and evaluate their versions of the INSPIRED program?Methods: Collaborative faculty selected measures that were evidence-based, relatively simple to collect, and relevant to local context. Chosen process and outcome measures are related to four quality domains: 1 patient- and family-centeredness, 2 coordination, 3 efficiency, and 4 appropriateness. Evaluation of a complex intervention followed a mixed-methods approach.Results: Most participants were nurse managers and/or COPD educators. Only 8% were physicians. Fifteen teams incorporated all core INSPIRED interventions. All teams carried out evaluation. Thirteen teams actively involved patients and families in customized, direct care planning, eg, asking them to complete evaluative surveys and/or conducting interviews. Patients consistently reported greater self-confidence in symptom management, a return to daily activities, and improvements to quality of life. Twelve teams collected data on care transitions using the validated three-item Care Transitions Measure (CTM-3. Twelve teams used the Lung Information Needs Questionnaire (LINQ. Admissions, emergency room visits, and patient-related costs fell substantially for

  9. High frequency equipment promotes antibacterial effects dependent on intensity and exposure time

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    Wietzikoski Lovato EC

    2018-03-01

    Full Text Available Evellyn Claudia Wietzikoski Lovato,1 Patrícia Amaral Gurgel Velasquez,1 Cristiana dos Santos Oliveira,1 Camila Baruffi,1 Thais Anghinoni,1 Raquel Costa Machado,1 Francislaine Aparecida dos Reis Lívero,2 Samantha Wietzikoski Sato,1 Lisiane de Almeida Martins1 1Laboratory of Microbiology of Natural Products, Paranaense University, Umuarama, Brazil; 2Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil Background: The indiscriminate use of antibiotics has caused bacteria to develop mechanisms of resistance to antibacterial agents, limiting treatment options. Therefore, there is a great need for alternative methods to control infections, especially those related to skin. One of the alternative methods is the high frequency equipment (HFE, which is used on skin conditions as an analgesic, an anti-inflammatory, and mainly to accelerate cicatricial processes and have a bactericidal effect through the formation of ozone. This research investigated the antibacterial effect of HFE on standard cultures of bacteria.Materials and methods: Dilutions (104 colony forming unit mL−1 were performed for Enterobacter aerogenes and Staphylococcus aureus with 24-hour growth bacteria. Then, 1 μL of each dilution was pipetted into suitable medium and the HFE flashing technique was used at intensities of 6, 8 and 10 mA for 30, 60, 90, 120 and 180 seconds. The control group received no treatment. Plates were incubated at 37°C for 24 hours and then read.Results: The spark at intensity of 6 mA had no bactericidal effect on the E. aerogenes; however, a significant bacterial growth reduction occurred at intensity of 8 mA after 120 and 180 seconds, and at 10 mA, reduction in bacterial growth could already be verified at 30 seconds and total bacterial growth inhibition occurred in 180 seconds. For S. aureus, there was a strong bacterial growth inhibition at all intensities used; however, at 6 mA, absence of bacterium growth after

  10. PREFACE: Young Researcher Meeting, Trieste 2014

    Science.gov (United States)

    Agostini, F.; Antolini, C.; Aversa, R.; Cattani, G.; Di Stefano, M.; Longobardi, M.; Martinelli, M.; Miceli, A.; Migliaccio, M.; Paci, F.; Pietrobon, D.; Pusceddu, E.; Stellato, F.

    2014-12-01

    skills. Engaging the public and finding unconventional ways to communicate results turn out to be real assets in improving the quality of presentation of current research to peers, as well as to the general public. In this volume, we collect part of the contributions that have been presented at the conference. They cover topics in astrophysics and cosmology, particle and theoretical physics, soft and condensed matter, medical physics and applied physics. Given the recent experimental achievements in particle physics and cosmology, several contributions were focused on the latest results obtained in these fields, presenting the impact of experiments such as LHC and Planck to the community of young researchers and forecasting the future goals in these areas of research. Particular interest was aroused by the session fully dedicated to applied Physics and conservation of cultural assets. Besides the intrinsic scientific value of the discussed topics, the increasing relative weight of the applied Physics session is a demonstration of the benefits that fundamental science brings to the community. YRM Organising and Editorial Committee Fabio Agostini (fabio.agostini31@gmail.com) Telespazio A Finmeccanica Thales Company Claudia Antolini (claudia.antolini@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati and Fudan University Rossella Aversa (raversa@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Giordano Cattani (giordano.cattani@gmail.com) Marco Di Stefano (distefan@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Maria Longobardi (marialongobardi@gmail.com) Department of Condensed Matter Physics, University of Geneva Matteo Martinelli (martinelli@thphys.uni-heidelberg.de) SISSA - Scuola Internazionale Superiore di Studi Avanzati and Institut fur Theoretische Physik Alice Miceli (alice.miceli@uniroma2.it) Physics Department, University of Rome Tor Vergata Marina Migliaccio (mm858@ast.cam.ac.uk) Institute of Astronomy and

  11. The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

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    Serra R

    2014-05-01

    Full Text Available Raffaele Serra,1,2,* Luca Gallelli,3,* Angela Conti,1 Giovanni De Caridi,4 Mafalda Massara,4 Francesco Spinelli,4 Gianluca Buffone,1 Francesco Giuseppe Caliò,5 Bruno Amato,6 Simona Ceglia,7 Giuseppe Spaziano,8 Luca Scaramuzzino,9 Alessia Giovanna Ferrarese,10 Raffaele Grande,1 Stefano de Franciscis1,2 1Interuniversity Center of Phlebolymphology (CIFL, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy; 2Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy; 3Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy; 4Cardiovascular and Thoracic Department, University of Messina, Messina, Italy; 5Unit of Vascular Surgery, S Anna Hospital, Catanzaro, Italy; 6Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; 7Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; 8Department of Experimental Medicine, Second University of Naples, Naples, Italy; 9University Campus BioMedico of Rome, Rome, Italy; 10Department of General Surgery, University of Turin, Turin, Italy *These authors contributed equally to this work Background: Mixed venous and arterial ulcers account for approximately 15%–30% of all venous leg ulcerations. Several studies have shown that matrix metalloproteinases (MMPs and neutrophil gelatinase-associated lipocalin (NGAL play a central role in the pathophysiology of venous and arterial diseases. Some studies have shown the efficacy of glycosaminoglycans, such as sulodexide (SDX, in treating patients with leg ulcers. The aim of this study was to evaluate clinical effects of SDX and its correlation with MMPs and NGAL expression in patients with mixed arterial and venous leg ulcers. Methods: Patients eligible for this study were of both sexes, older than 20 years, and with a

  12. Short-Term Efficacy of an Innovative Mobile Phone Technology-Based Intervention for Weight Management for Overweight and Obese Adolescents: Pilot Study.

    Science.gov (United States)

    Chen, Jyu-Lin; Guedes, Claudia M; Cooper, Bruce A; Lung, Audrey E

    2017-08-02

    .75, P=.006), and dietary self-efficacy (z=5.05, P=.001). Medium to large effect sizes were found in these outcome variables. The use of mobile technologies may offer a practical, reliable adjunct to weight management for overweight and obese adolescents in busy primary care clinics serving adolescents. Clinicaltrials.gov NCT 01693250; https://clinicaltrials.gov/ct2/show/NCT01693250? term=Adolescent+ obesity+AND+mhealth&rank=5 (Archived by WebCite at ). ©Jyu-Lin Chen, Claudia M Guedes, Bruce A Cooper, Audrey E Lung. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 02.08.2017.

  13. Towards development of novel immunization strategies against leishmaniasis using PLGA nanoparticles loaded with kinetoplastid membrane protein-11

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    Santos DM

    2012-04-01

    Full Text Available Diego M Santos1, Marcia W Carneiro1, Tatiana R de Moura1, Kiyoshi Fukutani1, Jorge Clarencio1, Manuel Soto2, Socorro Espuelas3,4, Claudia Brodskyn1,5, Aldina Barral1,5, Manoel Barral-Netto1,5, Camila I de Oliveira1,51Centro de Pesquisas Gonçalo Moniz, FIOCRUZ, Salvador, BA, Brazil; 2Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Madrid; 3Departamento de Farmacia y Tecnología Farmacéutica, 4Instituto de Salud Tropical, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain; 5Instituto de Investigação em Imunologia, Salvador, BA, BrazilBackground: Vaccine development has been a priority in the fight against leishmaniases, which are vector-borne diseases caused by Leishmania protozoa. Among the different immunization strategies employed to date is inoculation of plasmid DNA coding for parasite antigens, which has a demonstrated ability to induce humoral and cellular immune responses. In this sense, inoculation of plasmid DNA encoding Leishmania kinetoplasmid membrane protein-11 (KMP-11 was able to confer protection against visceral leishmaniasis. However, recently the use of antigen delivery systems such as poly(lactic-co-glycolic acid (PLGA nanoparticles has also proven effective for eliciting protective immune responses.Methods: In the present work, we tested two immunization strategies with the goal of obtaining protection, in terms of lesion development and parasite load, against cutaneous leishmaniasis caused by L. braziliensis. One strategy involved immunization with plasmid DNA encoding L. infantum chagasi KMP-11. Alternatively, mice were primed with PLGA nanoparticles loaded with the recombinant plasmid DNA and boosted using PLGA nanoparticles loaded with recombinant KMP-11.Results: Both immunization strategies elicited detectable cellular immune responses with the presence of both proinflammatory and anti

  14. Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

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    Saúde ACM

    2014-10-01

    Full Text Available Amanda CM Saúde,1 Alicia S Ombredane,1 Osmar N Silva,1 João ARG Barbosa,1,2 Susana E Moreno,3 Ana Claudia Guerra Araujo,4 Rosana Falcão,4 Luciano P Silva,4 Simoni C Dias,1 Octávio L Franco1,3 1Programa de Pós Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brasília, FD, Brazil; 2Laboratório de Biofísica-Departamento de Biologia Celular-IB, Universidade de Brasília – UNB, DF, Brazil; 3Universidade Católica Dom Bosco – UCDB, Campo Grande, MS, Brazil; 4Empresa Brasileira de Pesquisa Agropecuária – EMBRAPA – Recursos Genéticos e Biotecnologia, Brasília, DF, Brazil Abstract: Controlling human pathogenic bacteria is a worldwide problem due to increasing bacterial resistance. This has prompted a number of studies investigating peptides isolated from marine animals as a possible alternative for control of human pathogen infections. Clavanins are antimicrobial peptides isolated from the marine tunicate Styela clava, showing 23 amino acid residues in length, cationic properties, and also high bactericidal activity. In spite of clear benefits from the use of peptides, currently 95% of peptide properties have limited pharmaceutical applicability, such as low solubility and short half-life in the circulatory system. Here, nanobiotechnology was used to encapsulate clavanin A in order to develop nanoantibiotics against bacterial sepsis. Clavanin was nanostructured using EUDRAGIT® L 100-55 and RS 30 D solution (3:1 w:w. Atomic force, scanning electron microscopy and dynamic light scattering showed nanoparticles ranging from 120 to 372 nm in diameter, with a zeta potential of -7.16 mV and a polydispersity index of 0.123. Encapsulation rate of 98% was assessed by reversed-phase chromatography. In vitro bioassays showed that the nanostructured clavanin was partially able to control development of Staphylococcus aureus, Klebsiella pneumoniae, and

  15. Long-term outcome of laparoscopic and open surgery in patients with Crohn’s disease

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    Hoffmann M

    2017-11-01

    Full Text Available Martin Hoffmann,1 Dina Siebrasse,1 Erik Schlöricke,2 Ralf Bouchard,1 Tobias Keck,1 Claudia Benecke1 1Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, 2Department of Surgery, Westküstenklinikum Heide, Heide, Germany Aim: To investigate, via data analysis, the long-term outcome of patients who underwent either laparoscopic or open surgery for Crohn’s disease.Methods: A total of 113 patients who had undergone first abdominal surgery due to Crohn’s disease between January 2000 and December 2010 in a maximum care provider facility, were included in the statistical analysis. All patients provided their informed consent prior to inclusion. Data were collected from a database. Follow-up data included data from central mortality registries, general practitioners and a specialized clinic. Statistical analysis of the general patient data and the different operations and approaches were performed with the use of chi-square test, Fisher’s exact test, and the Mann–Whitney U test.Results: The median follow-up period in case of open and laparoscopic surgery was found to be 9 and 6 years, respectively. Statistically significant differences were observed for the following parameters in case of open and laparoscopic surgery, respectively: age (median=44 vs. 36 years, range=15–76 vs. 15–72 years; p=0.007, urgency of operation (23 out of 34 planned vs. 6 out of 70 planned; p<0.001, year of resection (median=2003 vs. 2006, range=2000–2010 vs. 2000–2010; p=0.001. The length of stay in hospital was significantly shorter in the laparoscopic group than that of open surgery group (8 vs. 11 days, respectively; p<0.0001. We did not control for factors such as age and comorbidities in our statistical analysis. We also did not find any differences with regard to perioperative and 90-day mortality, surgical complications, length of specimen, stoma, surgical recurrence rate (10% in both groups and number of re

  16. Nurse home visits with or without alert buttons versus usual care in the frail elderly: a randomized controlled trial

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    Favela J

    2013-01-01

    Full Text Available Jesús Favela,1 Luis A Castro,2 Francisco Franco-Marina,3 Sergio Sánchez-García,4 Teresa Juárez-Cedillo,4 Claudia Espinel Bermudez,4 Julia Mora-Altamirano,4 Marcela D Rodriguez,5 Carmen García-Peña41Center for Scientific Research and Higher Education of Ensenada, Ensenada, Baja California, Mexico; 2Sonora Institute of Technology, Ciudad Obregon, Mexico; 3National Institute of Respiratory Diseases, Mexican Ministry of Health, Mexico City, Mexico; 4Epidemiologic and Health Service Research Unit, Aging Area, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; 5School of Engineering, MyDCI, Autonomous University of Baja California, Mexicali, MexicoObjective: To assess whether an intervention based on nurse home visits including alert buttons (NV+AB is effective in reducing frailty compared to nurse home visits alone (NV-only and usual care (control group for older adults.Design: Unblinded, randomized, controlled trial.Setting: Insured population covered by the Mexican Social Security Institute living in the city of Ensenada, Baja California, Mexico.Participants: Patients were aged over 60 years with a frailty index score higher than 0.14.Intervention: After screening and informed consent, participants were allocated randomly to the control, NV+AB, or NV-only groups.Measurements: The primary outcome was the frailty score 9 months later. Quality of life, depression, comorbidities, health status, and health service utilization were also considered.Results: The framing sample included 819 patients. Of those, 591 were not located because they did not have a landline/telephone (341 patients, they had died (107, they were ill (50, or they were not currently living in the city (28. A screening interview was applied to 228 participants, and 57 had a score ≤0.14, 171 had ≥0.14, and 16 refused to complete the baseline questionnaire. A home visit was scheduled for 155 patients. However, 22 did not complete

  17. CoCo trial: Color-coded blood pressure Control, a randomized controlled study

    Directory of Open Access Journals (Sweden)

    Chmiel C

    2014-10-01

    Full Text Available Corinne Chmiel, Oliver Senn, Thomas Rosemann, Valerio Del Prete, Claudia Steurer-Stey Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland Background: Inadequate blood pressure (BP control is a frequent challenge in general practice. The objective of this study was to determine whether a color-coded BP booklet using a traffic light scheme (red, >180 mmHg systolic BP and/or >110 mmHg diastolic BP; yellow, >140–180 mmHg systolic BP or >90–110 mmHg diastolic BP; green, ≤140 mmHg systolic BP and ≤90 mmHg diastolic BP improves BP control and adherence with home BP measurement.Methods: In this two-group, randomized controlled trial, general practitioners recruited adult patients with a BP >140 mmHg systolic and/or >90 mmHg diastolic. Patients in the control group received a standard BP booklet and the intervention group used a color-coded booklet for daily home BP measurement. The main outcomes were changes in BP, BP control (treatment goal <140/90 mmHg, and adherence with home BP measurement after 6 months.Results: One hundred and twenty-one of 137 included patients qualified for analysis. After 6 months, a significant decrease in systolic and diastolic BP was achieved in both groups, with no significant difference between the groups (16.1/7.9 mmHg in the intervention group versus 13.1/8.6 mmHg in the control group, P=0.3/0.7. BP control (treatment target <140/90 mmHg was achieved significantly more often in the intervention group (43% versus 25%; P=0.037; number needed to treat of 5. Adherence with home BP measurement overall was high, with a trend in favor of the intervention group (98.6% versus 96.2%; P=0.1Conclusion: Color-coded BP self-monitoring significantly improved BP control (number needed to treat of 5, meaning that every fifth patient utilizing color-coded self-monitoring achieved better BP control after 6 months, but no significant between-group difference was

  18. Bromfenac 0.09% bioavailability in aqueous humor, prophylactic effect on cystoid macular edema, and clinical signs of ocular inflammation after phacoemulsification in a Mexican population

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    Palacio C

    2016-01-01

    Full Text Available Claudia Palacio,1 Lourdes Fernández De Ortega,2 Francisco R Bustos,3 Eduardo Chávez,4 Aldo A Oregon-Miranda,5 Arieh R Mercado-Sesma5 1Anterior Segment Department, Fundación Hospital Nuestra Señora de la Luz, México City, México; 2Anterior Segment Department, Asociación Para Evitar la Ceguera en México, Hospital Dr Luis Sánchez Bulnes, México; 3Anterior Segment Department, Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México; 4Anterior Segment Department, Instituto de Oftalmología, Fundación de Asistencia Privada Conde de Valenciana, IAP, México; 5Clinical Research Department, Laboratorios Sophia, SA de CV, Zapopan, Jalisco, México Purpose: The purpose of this study was to evaluate the aqueous humor bioavailability and clinical efficacy of bromfenac 0.09% vs nepafenac on the presence of cystoid macular edema (CME after phacoemulsification.Material and methods: A Phase II, double-blind, masked, active-controlled, multicenter, clinical trial of 139 subjects, randomized to either a bromfenac 0.09% ophthalmic solution (n=69 or nepafenac 0.1% (n=70. Subjects instilled a drop three times a day for a period of 30 days. Follow-up visits were on days 2, 7, 15, 30, and 60. Biomicroscopy, clinical ocular signs, and assessment of posterior segment were performed. The primary efficacy endpoints included the presence of CME evaluated by optical coherence tomography. Safety evaluation included intraocular pressure, transaminase enzymes, lissamine green, and fluorescein stain.Results: The demographic and efficacy variables were similar between groups at baseline. The presence of pain, photophobia, conjunctival hyperemia, chemosis, cellularity, and corneal edema disappeared by day 30 in both groups. The central retinal thickness did not show significant changes after treatment when compared to baseline as follows: in the bromfenac group (247.2±32.9 vs 252.0±24.9 µm; P=0.958 and in nepafenac group (250.8±34

  19. Impact of everolimus: update on immunosuppressive therapy strategies and patient outcomes after renal transplantation

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    Helio Tedesco-Silva Jr

    2011-01-01

    Full Text Available Helio Tedesco-Silva Jr, Claudia Rosso Felipe, Tainá Veras de Sandes Freitas, Marina Pontello Cristeli, Carolina Araújo Rodrigues, José Osmar Medina PestanaNephrology Division, Hospital do Rim e Hipertensão, Universidade Federal de São Paulo, BrazilAbstract: Everolimus is an immunosuppressive agent used for the prophylaxis of acute rejection after kidney transplantation. Everolimus inhibits the activity of the serine/threonine kinase mammalian target of rapamycin (mTOR, a key enzyme that controls cell growth and metabolism, producing cell cycle arrest from the G1 to S phase. As a consequence, everolimus has antiproliferative and antineoplastic effects. Everolimus is a drug with a narrow therapeutic index. The pharmacokinetics of everolimus indicates a need for twice-daily dosing. Intra- and interindividual variability and drug–drug interactions suggest the need for therapeutic drug monitoring to maximize the efficacy/toxicity ratio. The good correlation between exposure (area under the concentration–time curve and trough concentration indicates that monitoring of everolimus trough concentrations is an adequate strategy after kidney transplantation. Everolimus is indicated for low- to moderate-risk de novo kidney transplant candidates. There are no conclusive studies thus far indicating that everolimus can be used in high-risk patients, such as sensitized patients, retransplants, and African Americans. In de novo kidney transplant recipients, the recommended initial dose of everolimus is 0.75 mg twice daily, adjusted to maintain blood trough concentrations of 3–8 ng/mL, in combination with progressive reduction in blood trough cyclosporine concentrations to 25–50 ng/mL. In combination with reduced trough blood tacrolimus concentrations of 4–7 ng/mL the recommended initial dose of everolimus is 1.5 mg twice daily, adjusted to maintain trough blood concentrations of 3–8 ng/mL. Everolimus can also be used as a conversion strategy

  20. Vegetation and land carbon feedbacks in the high-resolution transient Holocene simulations using the MPI Earth system model

    Science.gov (United States)

    Brovkin, Victor; Lorenz, Stephan; Raddatz, Thomas

    2017-04-01

    üger1, Roberta D'agostino1, Anne Dallmeyer1, Sabine Egerer1, Vivienne Groner1, Matthias Heinze1, Tatiana Ilyina1, Johann Jungclaus1, Thomas Kleinen1, Alexander Lemburg1, Stephan Lorenz1, Thomas Raddatz1, Hauke Schmidt1, Gerhard Schmiedl3, Bjorn Stevens1, Claudia Timmreck1, Matthew Toohey4 1Max-Planck-Institut für Meteorologie, D 2Wageningen University, NL 3CEN, Universität Hamburg, D 4GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, D

  1. Adaptation, Implementation Plan, and Evaluation of an Online Tobacco Cessation Training Program for Health Care Professionals in Three Spanish-Speaking Latin American Countries: Protocol of the Fruitful Study.

    Science.gov (United States)

    Martínez, Cristina; Company, Assumpta; Guillen, Olga; Margalef, Mercè; Arrien, Martha Alicia; Sánchez, Claudia; Cáceres de León, Paula; Fernández, Esteve

    2017-01-27

    evaluation. There is a need to learn more about the cultural and content elements that should be modified when an online tobacco cessation training program is adapted to new contexts. Special attention should be given to the personal and material resources that could make the implementation possible. Results from the Fruitful Study may offer a new approach to adapting programs to LMICs in order to offer education solutions with the use of emerging and growing communication technologies. Clinicaltrials.gov NCT02718872; https://clinicaltrials.gov/ct2/show/NCT02718872 (Archived by WebCite at http://www.webcitation.org/6mjihsgE2). ©Cristina Martínez, Assumpta Company, Olga Guillen, Mercè Margalef, Martha Alicia Arrien, Claudia Sánchez, Paula Cáceres de León, Esteve Fernández, Group of Hospital Coordinators in the Fruitful Project. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 27.01.2017.

  2. Novedades bibliográficas

    Directory of Open Access Journals (Sweden)

    Anuario Colombiano de Historia Social y de la Cultura

    2002-01-01

    . Pennsylvania:  Pennsylvania  Press University, 2000.  388, pp., ilustraciones, índices. /  Afrodesccndientes en las Américas: Travectorias sociales e identitarias. 150 años de la abolición de la esclavitud en Colombia. Claudia Mosquera, Mauricio Pardo y Odile Hüñmant (editores. Bogotá: UNAL-ICANH-IRD-ILSA, 2002. 61O pp .. gráficas e ilustraciones.

  3. Blood pressure reactivity to mental stress is attenuated following resistance exercise in older hypertensive women

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    Gauche R

    2017-05-01

    Full Text Available Rafael Gauche,1 Ricardo M Lima,1,2 Jonathan Myers,2 André B Gadelha,1 Silvia GR Neri,1 Claudia LM Forjaz,3 Lauro C Vianna1 1Faculty of Physical Education, University of Brasília, Brasília, Brazil; 2Cardiology Division, Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, CA, USA; 3School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil Purpose: This study aimed to investigate the effects of resistance exercise (RE on autonomic control and blood pressure (BP reactivity during mental stress (MS in treated older hypertensive women. Methods: Ten older hypertensive women (age =71.1±5.5 years; body mass index =24.2±3.9; mean BP [MBP] =85.4±3.5 underwent a protocol consisting of BP and heart rate variability (HRV output assessments at baseline and during MS, and these measurements were taken before and 60 minutes after two bouts of RE (traditional and circuit. MS was induced through a computerized 3-minute Stroop color–word test before and 1 hour after each exercise session; BP was measured every minute during MS, and HRV was monitored as a measure of cardiac autonomic control. Results: A significant effect of time on systolic BP (∆pre =17.4±12.8 versus ∆post =12.5±9.6; P=0.01, diastolic BP (∆pre =13.7±7.1 versus ∆post =8.8±4.5; P=0.01, and MBP (∆pre =14.0±7.7 versus ∆post =9.3±5.4; P<0.01 after RE was observed, with no differences between the two sessions. In addition, a significant effect of time on log-normalized low-frequency component of HRV (ms2; 5.3±0.8 pre-exercise MS versus 4.8±1.0 baseline value; P=0.023 was also observed, showing a significant change from baseline to MS before RE, but not after RE sessions. These results may be related to a lessened RE-mediated cardiac sympathetic activity during MS. Conclusion: RE is an effective tool to reduce BP reactivity to MS, which could therefore be associated with an acute reduction in cardiovascular risk. This

  4. Estimating the real world daily usage and cost for exenatide twice daily and liraglutide in Germany, the Netherlands, and the UK based on volumes dispensed by pharmacies

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    McDonell AL

    2015-01-01

    Full Text Available Amanda L McDonell,1 Urpo Kiiskinen,2 Danielle C Zammit,3 Robert W Kotchie,1 Per-Olof Thuresson,3 Claudia Nicolay,4 Thomas Haslam,1 Michiel Bruinsma,5 Anne-Jeanine Janszen-Van Oosterhout,6 Thorsten Otto41IMS Health, London, UK; 2Eli Lilly and Company, Helsinki, Finland; 3IMS Health, Basel, Switzerland; 4Eli Lilly and Company, Bad Homburg, Germany; 5IMS Health, Rotterdam, the Netherlands; 6Eli Lilly Nederland, Houten, the NetherlandsBackground: Glucagon-like peptide-1 (GLP-1 receptor agonists are indicated for improvement of glycemic control in adults with type 2 diabetes. Cost is one aspect of treatment to be considered, in addition to clinical benefits, when selecting optimal therapy for a patient. The objective of this study was to estimate the average dose usage and real world daily cost of the GLP-1 receptor agonists, exenatide twice daily and liraglutide once daily, in Germany, the Netherlands, and the UK.Methods: Administrative databases were used to source the data from longitudinal records of dispensed prescriptions. Data were extracted from the IMS Longitudinal Prescription database which captures details of prescriptions dispensed in pharmacies. Information on the dispensed quantity of each product was used to estimate average daily usage per patient. Daily dose usage was multiplied by the public price per unit to estimate daily cost.Results: The dispensed volume in Germany corresponded to a mean dispensed daily dose of 16.81 µg for exenatide twice daily and 1.37 mg for liraglutide (mean daily cost €4.02 and €4.54, respectively. In the Netherlands, average dispensed daily doses of 17.07 µg and 1.49 mg were observed for exenatide twice daily and liraglutide (mean daily cost €3.05 and €3.97, respectively. In the UK, the mean dispensed volume corresponded to a daily usage of 20.49 µg for exenatide twice daily and 1.50 mg for liraglutide (mean daily cost £2.53 and £3.28, respectively.Conclusion: Estimates of average daily

  5. Preventing Depression in Adults With Subthreshold Depression: Health-Economic Evaluation Alongside a Pragmatic Randomized Controlled Trial of a Web-Based Intervention.

    Science.gov (United States)

    Buntrock, Claudia; Berking, Matthias; Smit, Filip; Lehr, Dirk; Nobis, Stephanie; Riper, Heleen; Cuijpers, Pim; Ebert, David

    2017-01-04

    D and adds that this not only restores health in people with sD, but additionally reduces the risk of developing a MDD. Offering the intervention has an acceptable likelihood of being more cost-effective than enhanced usual care and could therefore reach community members on a wider scale. German Clinical Trials Register: DRKS00004709; http://www.drks.de/DRKS00004709 (Archived by WebCite at http://www.webcitation.org/6kAZVUxy9). ©Claudia Buntrock, Matthias Berking, Filip Smit, Dirk Lehr, Stephanie Nobis, Heleen Riper, Pim Cuijpers, David Ebert. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 04.01.2017.

  6. The role of the arginine metabolome in pain: implications for sickle cell disease

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    Bakshi N

    2016-03-01

    Full Text Available Nitya Bakshi,1–2 Claudia R Morris3–6 1Division of Pediatric Hematology-Oncology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; 2Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA, USA; 3Division of Pediatric Emergency Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; 4Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA; 5Emory-Children’s Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine, Atlanta, GA, USA; 6Pediatric Emergency Medicine, Children’s Healthcare of Atlanta, Atlanta, GA, USA Abstract: Sickle cell disease (SCD is the most common hemoglobinopathy in the US, affecting approximately 100,000 individuals in the US and millions worldwide. Pain is the hallmark of SCD, and a subset of patients experience pain virtually all of the time. Of interest, the arginine metabolome is associated with several pain mechanisms highlighted in this review. Since SCD is an arginine deficiency syndrome, the contribution of the arginine metabolome to acute and chronic pain in SCD is a topic in need of further attention. Normal arginine metabolism is impaired in SCD through various mechanisms that contribute to endothelial dysfunction, vaso-occlusion, pulmonary complications, risk of leg ulcers, and early mortality. Arginine is a semiessential amino acid that serves as a substrate for protein synthesis and is the precursor to nitric oxide (NO, polyamines, proline, glutamate, creatine, and agmatine. Since arginine is involved in multiple metabolic processes, a deficiency of this amino acid has the potential to disrupt many cellular and organ functions. NO is a potent vasodilator that is depleted in SCD and may contribute to vaso-occlusive pain. As the obligate substrate for NO production, arginine also plays a mechanistic role in SCD-related pain, although its

  7. Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation

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    Di Bonito P

    2017-06-01

    Full Text Available Paola Di Bonito,1 Chiara Chiozzini,2 Claudia Arenaccio,2 Simona Anticoli,2 Francesco Manfredi,2 Eleonora Olivetta,2 Flavia Ferrantelli,2 Emiliana Falcone,3 Anna Ruggieri,3 Maurizio Federico2 1Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy; 2National AIDS Center, Istituto Superiore di Sanità, Rome, Italy; 3Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy Abstract: We recently proved that exosomes engineered in vitro to deliver high amounts of HPV E7 upon fusion with the Nefmut exosome-anchoring protein elicit an efficient anti-E7 cytotoxic T lymphocyte immune response. However, in view of a potential clinic application of this finding, our exosome-based immunization strategy was faced with possible technical difficulties including industrial manufacturing, cost of production, and storage. To overcome these hurdles, we designed an as yet unproven exosome-based immunization strategy relying on delivery by intramuscular inoculation of a DNA vector expressing Nefmut fused with HPV E7. In this way, we predicted that the expression of the Nefmut/E7 vector in muscle cells would result in a continuous source of endogenous (ie, produced by the inoculated host engineered exosomes able to induce an E7-specific immune response. To assess this hypothesis, we first demonstrated that the injection of a Nefmut/green fluorescent protein-expressing vector led to the release of fluorescent exosomes, as detected in plasma of inoculated mice. Then, we observed that mice inoculated intramuscularly with a vector expressing Nefmut/E7 developed a CD8+ T-cell immune response against both Nef and E7. Conversely, no CD8+ T-cell responses were detected upon injection of vectors expressing either the wild-type Nef isoform of E7 alone, most likely a consequence of their inefficient exosome incorporation. The production of immunogenic exosomes in the DNA

  8. Characterizing Active Ingredients of eHealth Interventions Targeting Persons With Poorly Controlled Type 2 Diabetes Mellitus Using the Behavior Change Techniques Taxonomy: Scoping Review.

    Science.gov (United States)

    Kebede, Mihiretu M; Liedtke, Tatjana P; Möllers, Tobias; Pischke, Claudia R

    2017-10-12

    explicit to avoid ambiguity. Response: Checked and avoided of a certain behavior Author: Please note that the journal discourages the use of parenthesis to denote either and/or and prefers to be explicit to avoid ambiguity. Response: Checked and avoided "and/or" and prefers to be explicit to avoid ambiguity. Response: Checked and avoided, and feedback on outcomes of behavior. Our results suggest that the majority of BCTs employed in interventions targeting persons with T2DM revolve around the promotion of self-regulatory behavior to manage the disease or to assist patients in performing health behaviors necessary to prevent further complications of the disease. Detailed reporting of the BCTs included in interventions targeting this population may facilitate the replication and further investigation of such interventions. ©Mihiretu M Kebede, Tatjana P Liedtke, Tobias Möllers, Claudia R Pischke. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 12.10.2017.

  9. O Ethos do dicionarista, um olhar sobre o prefácio

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    Silvia Oliveira Rosa Fernandes

    2013-08-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2013v2n32p227 As ideias que habitam este texto tiveram como primeira morada a tese Vozes na colônia, um estudo discursivo sobre os dicionários gerais de língua, recentemente defendida. A pesquisa buscava trilhar, pelo viés da modalização nas acepções dos verbetes, os caminhos pelos quais diferentes vozes atravessam a trama discursiva dos dicionários gerais de língua no corpus constituído pelos dicionários Houaiss (2009 e Aurélio (2010, em suas edições mais recentes, já adequadas ao novo acordo. Ao buscar essas vozes, tentamos entender o dicionário como um gênero que é múltiplo mesmo em sua essência, posto que agrega outros gêneros, como verbetes, prefácio, bibliografia, apresentação. Também nos serviu de norte o conceito de que, como todo gênero, o dicionário é um construto social, que se ergue na confluência das necessidades de comunicação e possui regras de um contrato, que se estabelece, no seu caso, entre autor (dicionarista e leitor (consulente. As duas obras que serviram de corpus para pesquisa, e cujos prefácios observaremos aqui, são resultado de um trabalho forjado em equipe, de modo que o nome dos autores constitui uma chancela de qualidade em vez de marcar a autoria do produto. Assim, entendendo que o sujeito produtor do enunciado não é único, estabelecemos o dicionarista como uma entidade discursiva e delineamos seu ethos por meio das características da obra lexicográfica e do seu produtor pinceladas em diferentes textos metalexicográficos, como os de Margarita Correia (2009, Francisco da Silva Borba (2003, Maria Teresa C. Biderman (1984, 1998, José Horta Nunes (2002, Claudia Xatara (2011 e Hebert Welker (2004, 2006. Além da metalexicografia, nos guiaram os estudos de Dominique Maingueneau (1997, 2000, Patrick Charaudeau e Maingueneau (2006 e Ruth Amossy (2005 sobre polifonia e ethos discursivo. Partindo do que se diz do dicionário para dentro dele, no

  10. Clinical correlates of complicated grief among individuals with acute coronary syndromes

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    Pini S

    2015-10-01

    Full Text Available Stefano Pini,1 Camilla Gesi,1 Marianna Abelli,1 Alessandra Cardini,1 Lisa Lari,1 Francesca Felice,2 Rossella Di Stefano,2 Gianfranco Mazzotta,3 Francesco Bovenzi,4 Daniele Bertoli,5 Lucia Borelli,4 Paola Michi,1 Claudia Oligeri,3 Alberto Balbarini,2 Vijaya Manicavasagar6 1Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, 2Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, 3Unit of Cardiology, Ospedale Sant’Andrea, La Spezia, 4Cardio-Respiratory Department, Ospedale Campo di Marte, Lucca, 5Unit of Cardiology, Ospedale San Bartolomeo, Sarzana (SP, Italy; 6Black Dog Institute, University of New South Wales, Sydney, NSW, Australia Objective: The study aimed at exploring bereavement and complicated grief (CG symptoms among subjects without a history of coronary heart disease (CHD at the time of a first acute coronary syndrome (ACS and to evaluate the relationship of CG symptoms and ACS. Method: Overall, 149 subjects with ACS (namely, acute myocardial infarct with or without ST-segment elevation or unstable angina, with no previous history of CHD, admitted to three cardiac intensive care units were included and evaluated by the Structured Clinical Interview for Complicated Grief (SCI-CG, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and the 36-item Short-Form Health Survey (MOS-SF-36. Results: Of the total sample of 149 subjects with ACS, 118 (79.2% met criteria for DSM-5 persistent complex bereavement disorder. Among these, subjects who lost a partner, child, or sibling were older (P=0.008, less likely to be working (P=0.032, and more likely to be suffering from hypertension (P=0.021, returned higher scores on the SCI-CG (P=0.001 and developed the index ACS more frequently between 12 and 48 months after the death than those who lost a parent or another relative (P≤0.0001. The occurrence of ACS 12–48 months (P=0.019 after the loss was

  11. Safety, tolerability, and efficacy of a fixed-dose combination of olmesartan 40 mg and hydrochlorothiazide 12.5/25 mg in daily practice

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    Bramlage P

    2013-08-01

    Full Text Available Peter Bramlage,1 Claudia Zemmrich,1 Reinhard Ketelhut,2 Wolf-Peter Wolf,3 Eva-Maria Fronk,4 Roland E Schmieder5 1Institut für Pharmakologie und Präventive Medizin, Mahlow, Germany; 2Institut für Sportmedizin, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Berlin, Germany; 3Daiichi Sankyo Deutschland GmbH, Munich, Germany; 4Daiichi Sankyo Europe GmbH, Munich, Germany; 5Universitätsklinikum Erlangen, Klinik für Nephrologie und Hypertensiologie, Erlangen, Germany Background: The safety and efficacy of olmesartan 40 mg and hydrochlorothiazide (HCTZ as a fixed-dose combination has been investigated in clinical trials leading to its approval. The aims of the present study were to confirm these data in an unselected patient population in daily practice and to determine the impact of physical activity on blood pressure control. Methods: In a multicenter, noninterventional study, 3,333 patients with either insufficient blood pressure control on olmesartan 40 mg alone or on a fixed/free combination of olmesartan 40 mg and HCTZ 12.5/25 mg were primarily assessed for safety and tolerability of the fixed-dose combination of olmesartan 40 mg and HCTZ 12.5/25 mg at 24 ± 2 weeks. Secondary objectives were blood pressure reduction, treatment compliance, and impact of physical activity as measured by the sum of weekly energy costs. Results: The mean patient age was 63.2 ± 11.46 years, mean baseline blood pressure was 159.6 ± 15.28/93.5 ± 9.52 mmHg, and 70.9% had at least one additional cardiovascular risk factor. Adverse drug reactions were rare (n = 19, and no serious adverse drug reactions occurred. Compliance with drug therapy was at least sufficient in more than 99% of patients at the end of the study. Blood pressure at the last available visit was reduced by 26.1 ± 15.5/13.0 ± 10.1 mmHg versus baseline (P < 0.0001, but had reduced effectiveness in patients ≥75 years with diabetes or impaired renal function. In 69% of patients

  12. Detecting Novel and Emerging Drug Terms Using Natural Language Processing: A Social Media Corpus Study.

    Science.gov (United States)

    Simpson, Sean S; Adams, Nikki; Brugman, Claudia M; Conners, Thomas J

    2018-01-08

    therefore considered to be successful cases of uncovering novel drug terminology. Several of these novel terms appear to have been introduced as recently as 1 or 2 months before the corpus time slice used to train the word embeddings. Though the precision of the method described here is low enough as to still necessitate human review of any candidate term lists generated in such a manner, the fact that this process was able to detect 30 novel terms for the target substance based only on one month's worth of Twitter data is highly promising. We see this pilot study as an important proof of concept and a first step toward producing a fully automated drug term discovery system capable of tracking emerging NPS terms in real time. ©Sean S Simpson, Nikki Adams, Claudia M Brugman, Thomas J Conners. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 08.01.2018.

  13. El foro romano de Termes (Hispania Citerior. Síntesis histórica, arqueológica y topográfica. S. I a. C.- s. II d. C.

    Directory of Open Access Journals (Sweden)

    Martínez Caballero, Santiago

    2010-12-01

    progresiva superposición de estructuras en la zona. Durante la etapa Julio Claudia (14-37 d. C. se creó una nueva área pública, junto a la anterior, conformada por un recinto porticado con un templo. Este conjunto formaba parte de un espacio público principal, bien un Foro Julio Claudio, bien simplemente un santuario urbano. Finalmente, en época flavia, a partir de 75 d. C., el sitio del foro augusteo será transformado con la construcción de un gran cuadripórtico monumental y escenográfico, el Foro Flavio, complejo que se constituirá, al mismo tiempo, como un foro y un Augusteum, espacio de representación y santuario de culto dinástico.

  14. Anaerobic digestion of solid biomass and biowaste

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Within the International Trade Fair for Biogas Plant Technology from 23rd to 24th February, 2012 in Berlin, the following lectures were held: (1) Presentation and results of the EU project 24biomass'' (Claudia Lutsyuk); (2) The Polish biogas market (Tomasz Surowiec); (3) Presence and future of the biogas sector in Poland - EBE project (Eugeniusz Jedrysik); (4) Modern biogas generation in Poland - Case studies of the company Poldanor (Jens Bo Holm-Nielsen); (5) Low space requirement - The challenge in the integration of biogas plants in existing composting facilities - examples from real life (Michael Oertig); (6) Integration of biogas plants in composting facilities by partial-flow fermentation (Bruno Mattheeuws); (7) The significance of an efficient removal of foreign matter from biomass before fermentation in a waste incinerator for municipal wastes (Stephan Schulte); (8) Sustainable enhancement of the anaerobic degradation and increase of the biogas production by means of ultrasonic treatment - examples from real life (Silvana Velten); (9) Cultivation of energy plants on sandy soils in the northeastern part of Germany (Gunter Ebel); (10) Topinambur, a new sustainable energy crop for biogas generation (Vito Pignatelli); (11) Potential of biogas generation from reed (Vilis Dubrovskis); (12) Biogas generation from maize straw - a new procedure of harvesting and processing (Thomas Amon); (13) Generation of biogas by cofermentation of pig manure and grass silage: a pilot study (Ximmin Zhan); (14) Thermophilic dry fermentation of poultry litter and energy crops for the generation of biogas, organic fertilizer and protection of water resources from environmental damages in the Mid-Atlantic region of the USA (John Intersoll); (15) Energetic utilisation of horse manure (Saskia Oldenburg); (16) Realization of the greatest and most modern Hungarian biogas plant in Szarvas (Ludwig Dinkloh); (16) Biogas in Russia - The investment program of the cooperation &apos

  15. Committees and organizers

    Science.gov (United States)

    2011-07-01

    (Orsay) S Hamann (Bochum)R Varga (Košice) U Hannemann (Dresden)P Vavassori (San Sebastian) L Havela (Prague)W Wulfhekel (Karlsruhe) O Heczko (Prague)M Yamashita (Sendai) B Hernando (Oviedo)R Zdyb (Lublin) O Isnard (Grenoble)A Zhukov (San Sebastián) Z Kąkol (Kraków)A K Zvezdin (Moscow) N-T H Kim-Ngan (Kraków) International Advisory Committee (2011): Dominique Givord, President (Grenoble)Ludwig Schultz, Former President (Dresden) Manfred Albrecht (Chemnitz)Burkard Hillebrands (Kaiserslautern) Agnés Barthélémy (Paris)Andrei Kirilyuk (Nijmegen) Roy Chantrell (York)Ron Jansen (Tsukuba) Russell Cowburn (London)Nicoleta Lupu (Iasi) Tomasz Dietl (Warszawa)Caroline A Ross (Cambridge, MA) Claudia Felser (Mainz)Stefano Sanvito (Dublin) Josef Fidler (Wien)Vladimir Sechovsky (Praha) Dino Fiorani (Roma)Roberta Sessoli (Firenze) Pietro Gambardella (Bellaterra)Jozef Spałek (Kraków) Alberto Guimarães (Rio de Janeiro)

  16. Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities

    Directory of Open Access Journals (Sweden)

    Sanna V

    2014-10-01

    Full Text Available Vanna Sanna,1,2 Nicolino Pala,1 Giuseppina Dessì,1 Paola Manconi,1 Alberto Mariani,1 Sonia Dedola,3 Mauro Rassu,3 Claudia Crosio,3 Ciro Iaccarino,3 Mario Sechi1,2 1Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy; 2Laboratory of Nanomedicine, Department of Chemistry and Pharmacy, University of Sassari, c/o Porto Conte Ricerche, Tramariglio, Alghero, Italy; 3Department of Biomedical Sciences, University of Sassari, Sassari, Italy Background: Gold nanoparticles (GNPs are likely to provide an attractive platform for combining a variety of biophysicochemical properties into a unified nanodevice with great therapeutic potential. In this study we investigated the capabilities of three different natural polyphenols, epigallocatechin-3-gallate (EGCG, resveratrol (RSV, and fisetin (FS, to allow synergistic chemical reduction of gold salts to GNPs and stabilization in a single-step green process. Moreover, antioxidant properties of the nanosystems, as well as preliminary antiproliferative activity and apoptotic process investigation of model EGCG-GNPs on stable clones of neuroblastoma SH-SY5Y cells expressing CFP-DEVD-YFP reporter, were examined. Methods: The GNPs were characterized by physicochemical techniques, polyphenol content, and in vitro stability. The antioxidant activity of the GNPs was also determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid cation (ABTS radical-scavenging assays. Stable clones of neuronal SH-SY5Y-CFP-DEVD-YFP were generated and characterized, and cell viability after treatment with EGCG-GNPs was assessed after 72 hours through a 3(4,5-dimethylthiazol-2yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2H-tetrazolium assay. Activation of the apoptotic pathways was also investigated by Western blot analysis. Results: With a diameter in the size range of 10–25 nm, the obtained nanoparticles (NPs were found to contain 2.71%, 3.23%, and 5.47% of EGCG

  17. PASCOS 2012 - 18th International Symposium on Particles Strings and Cosmology

    Science.gov (United States)

    2014-03-01

    (Sociedad Mexicana de Física), ICTP (International Centre for Theoretical Physics), BUAP (Benemérita Universidad Autónoma de Puebla), the Government of the State of Yucatán, the University of Hamburg, and Telmex. We also want to acknowledge the invaluable help of the staff of the Mexican Physical Society, in particular Lic. Santos Zúñniga Sánchez and Ms. Claudia Velasco Marín, and of the conference secretaries, Ms. Lizette Ramírez Bermúdez (UNAM) and Ms. Mariana del Castillo Sánchez (Cinvestav), for their support before, during and after the organization of PASCOS 2012. Last but not least, we would like to thank all the PASCOS 2012 participants for their attendance and for contributing to make the conference an engaging and stimulating event. The organizers, Myriam Mondragón, Adnan Bashir, David Delepine, Francisco Larios, Oscar Loaiza, Axel de la Macorra, Lukas Nellen, Sarira Sahu, Humberto Salazar and Liliana Velasco-Sevilla.

  18. Anaerobic digestion of solid biomass and biowaste

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Within the International Trade Fair for Biogas Plant Technology from 23rd to 24th February, 2012 in Berlin, the following lectures were held: (1) Presentation and results of the EU project 24biomass'' (Claudia Lutsyuk); (2) The Polish biogas market (Tomasz Surowiec); (3) Presence and future of the biogas sector in Poland - EBE project (Eugeniusz Jedrysik); (4) Modern biogas generation in Poland - Case studies of the company Poldanor (Jens Bo Holm-Nielsen); (5) Low space requirement - The challenge in the integration of biogas plants in existing composting facilities - examples from real life (Michael Oertig); (6) Integration of biogas plants in composting facilities by partial-flow fermentation (Bruno Mattheeuws); (7) The significance of an efficient removal of foreign matter from biomass before fermentation in a waste incinerator for municipal wastes (Stephan Schulte); (8) Sustainable enhancement of the anaerobic degradation and increase of the biogas production by means of ultrasonic treatment - examples from real life (Silvana Velten); (9) Cultivation of energy plants on sandy soils in the northeastern part of Germany (Gunter Ebel); (10) Topinambur, a new sustainable energy crop for biogas generation (Vito Pignatelli); (11) Potential of biogas generation from reed (Vilis Dubrovskis); (12) Biogas generation from maize straw - a new procedure of harvesting and processing (Thomas Amon); (13) Generation of biogas by cofermentation of pig manure and grass silage: a pilot study (Ximmin Zhan); (14) Thermophilic dry fermentation of poultry litter and energy crops for the generation of biogas, organic fertilizer and protection of water resources from environmental damages in the Mid-Atlantic region of the USA (John Intersoll); (15) Energetic utilisation of horse manure (Saskia Oldenburg); (16) Realization of the greatest and most modern Hungarian biogas plant in Szarvas (Ludwig Dinkloh); (16) Biogas in Russia - The investment program of the cooperation ''Bio

  19. Using the framework of corporate culture in “mergers” to support the development of a cultural basis for integrative medicine – guidance for building an integrative medicine department or service

    Directory of Open Access Journals (Sweden)

    Witt CM

    2015-01-01

    Full Text Available Claudia M Witt,1–3 Marion Pérard,2 Brian Berman,3,4 Susan Berman,4 Timothy C Birdsall,5 Horst Defren,6 Sherko Kümmel,7 Gary Deng,8 Gustav Dobos,9 Atje Drexler,10 Christine Holmberg,2 Markus Horneber,11 Robert Jütte,9 Lori Knutson,12 Christopher Kummer,13 Susanne Volpers,14 David Schweiger15 1University Hospital Zurich, Institute for Complementary and Integrative Medicine, Zurich, Switzerland; 2Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin, Berlin, Germany; 3University of Maryland School of Medicine, Center for Integrative Medicine, Baltimore, Maryland, USA; 4The Institute for Integrative Health, Baltimore, USA; 5Cancer Treatment Centers of America, Goodyear, Arizona, USA, 6Kliniken Essen Mitte, Evang, Huyssen-Stiftung/Knappschaft GmbH Patientenmanagement, Essen, Germany; 7Department of Senology, Breast Center, Kliniken Essen-Mitte, Evang. Huyssens Stiftung, Knappschaft GmbH, Essen, Germany; 8Memorial Sloan-Kettering Cancer Center, New York, USA; 9Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Academic Teaching Hospital of the University of Duisburg-Essen, Germany; 10Robert Bosch Foundation GmbH, Stuttgart, Germany; 11Department of Internal Medicine, Division of Oncology and Hematology, Paracelsus Medical University, Klinikum Nürnberg, Germany; 12Integrative Healthcare Solutions, Minneapolis, Minnesota, USA; 13Institute of Mergers, Acquisitions and Alliances (IMAA, Zurich, Switzerland; 14Frauenselbsthilfe nach Krebs, Bonn, Germany; 15Schweiger, Schweiger & Associates, Hilton Head Island, South Carolina, USA Background: An increasing number of clinics offer complementary or integrative medicine services; however, clear guidance about how complementary medicine could be successfully and efficiently integrated into conventional health care settings is still lacking. Combining conventional and complementary medicine into integrative medicine can be regarded as a kind of

  20. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2010-12-01

    Full Text Available The Atlantic World, 1450-2000, edited by Toyin Falola & Kevin D. Roberts (reviewed by Aaron Spencer Fogleman The Slave Ship: A Human History, by Marcus Rediker (reviewed by Justin Roberts Extending the Frontiers: Essays on the New Transatlantic Slave Trade Database, edited by David Eltis & David Richardson (reviewed by Joseph C. Miller "New Negroes from Africa": Slave Trade Abolition and Free African Settlement in the Nineteenth-Century Caribbean, by Rosanne Marion Adderley (reviewed by Nicolette Bethel Atlantic Diasporas: Jews, Conversos, and Crypto-Jews in the Age of Mercantilism, 1500-1800, edited by Richard L. Kagan & Philip D. Morgan (reviewed by Jonathan Schorsch Brother’s Keeper: The United States, Race, and Empire in the British Caribbean, 1937-1962, by Jason C. Parker (reviewed by Charlie Whitham Labour and the Multiracial Project in the Caribbean: Its History and Promise, by Sara Abraham (reviewed by Douglas Midgett Envisioning Caribbean Futures: Jamaican Perspectives, by Brian Meeks (reviewed by Gina Athena Ulysse Archibald Monteath: Igbo, Jamaican, Moravian, by Maureen Warner-Lewis (reviewed by Jon Sensbach Left of Karl Marx: The Political Life of Black Communist Claudia Jones, by Carole Boyce Davies (reviewed by Linden Lewis Displacements and Transformations in Caribbean Cultures, edited by Lizabeth Paravisini-Gebert & Ivette Romero-Cesareo (reviewed by Bill Maurer Caribbean Migration to Western Europe and the United States: Essays on Incorporation, Identity, and Citizenship, edited by Margarita Cervantes-Rodríguez, Ramón Grosfoguel & Eric Mielants (reviewed by Gert Oostindie Home Cooking in the Global Village: Caribbean Food from Buccaneers to Ecotourists, by Richard Wilk (reviewed by William H. Fisher Dead Man in Paradise: Unraveling a Murder from a Time of Revolution, by J.B. MacKinnon (reviewed by Edward Paulino Tropical Zion: General Trujillo, FDR, and the Jews of Sos

  1. Environmental politics. Actual research projects in the area of sectional themes of renewable energies; Umweltpolitik. Aktuelle Forschungsvorhaben im Bereich Querschnittsthemen der erneuerbaren Energien

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, Gisela; Boehme, Dieter; Nikol, Claudia (comps.)

    2006-08-15

    Within the meeting of the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (Berlin, Federal Republic of Germany) at 23rd to 24th February, 2006 in Berlin the following lectures were held: (1) Reaching the targets of development for renewable energies up to the year 2020 (Joachim Nitsch); (2) Introduction to the topics of cross-section projects in the area of renewable energy (Wolfhart Duerrschmidt); (3) Preparation and accompanying of the preparation of a report of experience according to paragraph 20 EEG (Frithjof Staiss); (4) Analysis and evaluation for the further EEG from total economic view (Claudia Kemfert); (5) Monitoring for the efficiency of the amended EEG and the development of the power generation from biomass (Daniela Thraen); (6) Monitoring for the efficiency of the amended EEG and the development of power generation from solar energy (Dieer Guennewig); (7) Market penetration of renewable energies in the German and European power market (Mario Ragwitz); (8) Ecologically optimized expansion of the renewable energy revisited: the sectorial challenges (Martin Pehnt); (9) Key issues for the development and introduction of budget independent instruments for the market penetration in the heating market (Michael Nast); (10) Material flow analysis of sustainable mobility in the context of the renewable energies till to 2030 (Uwe Fritsche); (11) Optimization for a sustainable expansion of the generation and utilization of biogas in Germany - Electricity, thermal energy, fuels (Guido Reinhardt); (12) A structural-economical-ecological comparison of regenerative energy technologies (RE) with Carbon Capture and Capture (CCS) (Manfred Fischedick); (13) Monitoring of support instruments for renewable energies in the power supply sector in the EU and scientific accompanying of the Feed-in-Cooperation (Mario Ragwitz); (14) Further development of the EU politics for the promotion of renewable energies in the European power supply single

  2. Nanoscaled hydrated antimony (V oxide as a new approach to first-line antileishmanial drugs

    Directory of Open Access Journals (Sweden)

    Franco AMR

    2016-12-01

    Full Text Available Antonia MR Franco,1 Iryna Grafova,2 Fabiane V Soares,1,3 Gennaro Gentile,4 Claudia DC Wyrepkowski,1,3 Marcos A Bolson,5 Ézio Sargentini Jr,5 Cosimo Carfagna,4 Markku Leskelä,2 Andriy Grafov2 1Laboratory of Leishmaniasis and Chagas Disease, National Institute of Amazonian Research (INPA, Manaus, Amazonas, Brazil; 2Department of Chemistry, University of Helsinki, Helsinki, Finland; 3Multi-Institutional Post-Graduate Program in Biotechnology, Federal University of Amazonas, Manaus, Amazonas, Brazil; 4Institute for Polymers, Composites, and Biomaterials, National Research Council, Pozzuoli, Naples Province, Italy; 5Laboratory of Environmental Chemistry, National Institute of Amazonian Research (INPA, Manaus, Amazonas, Brazil Background: Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V complexes are commercialized as sodium stibogluconate (Pentostam® and meglumine antimoniate (MA (Glucantime®. Ever-increasing drug resistance in the parasites limits the use of antimonials, due to the low drug concentrations being administered against high parasitic counts. Sb5+ toxicity provokes severe side effects during treatment. To enhance therapeutic potency and to increase Sb (V concentration within the target cells, we decided to try a new active substance form, a hydrosol of Sb2O5⋅nH2O nanoparticles (NPs, instead of molecular drugs. Methodology/principal findings: Sb2O5⋅nH2O NPs were synthesized by controlled SbCl5 hydrolysis in a great excess of water. Sb2O5⋅nH2O phase formation was confirmed by X-ray diffraction. The surface of Sb (V NPs was treated with ligands with a high affinity for target cell membrane receptors. The mean particle size determined by dynamic light scattering and transmission electron microscopy was ~35–45 nm. In vitro tests demonstrated a 2.5–3 times higher antiparasitic activity of Sb (V nanohybrid hydrosols

  3. Sustentabilidade e Gestão de Empreendimentos Hoteleiros: Analisando Hotéis de Campo Grande, Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Maria Claudia Mancuelho Malta

    2015-10-01

    intensification of the diffusion of the concept, and the effective promotion of its implementation as a method of organizational management - helping in the process of encouraging the establishment of harmonious relations between the different economic activities, the environment, the culture and the other socio-spatial characteristics of the territories. Keywords: Tourism. Hotel Enterprises. Sustainability. Campo Grande, MS, Brazil. Maria Claudia Mancuelho Malta – Mestre. Professor da Escola Superior de Administração e Negócios da Universidade Federal de Mato Grosso de Sul, Campo Grande, MS, Curriclo Lattes: http://lattes.cnpq.br/6276197262789514. E-mail: minimalta@hotmail.com Milton Augusto Pasquotto Mariani – Doutor. Professor nos Programa de Mestrado em Administração e no Mestrado Profissional em Estudos Fronteiriços, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul. Currículo Lattes: http://lattes.cnpq.br/0935409945176042. E-mail: miltmari@terra.com.br Dyego de Oliveira Arruda – Mestre. É Professor do Centro Federal de Educação Tecnológica Celso Suckow da Fonseca (CEFET-RJ, Campus Valença, RJ. Currículo Lattes: http://lattes.cnpq.br/5222976964204691. E-mail: dyego.arruda@gmail.com

  4. A dupla expressão da identidade do jornal The double expression of the newspaper's identity

    Directory of Open Access Journals (Sweden)

    Ana Claudia Mei Alves Oliveira

    2008-11-01

    plastic semiotics of J.-M. Floch. Two types of identity processing stand out in the esthetic arrangement of the newspaper's expression. The first is based on the name of the newspaper by an invariable esthetic of the arrangement of its distinctive peculiarities. Distinguishing it from up the other communications media, this difference makes up its nominal identity. The second type of identity is structured on the first page by variations in the arrangement of the elements that 64 Oliveira , Ana Claudia de. A dupla expressão da identidade do jornal. Revista Galáxia, São Paulo, n. 14, p. 63-80, dez. 2007. constitute the syntagm, revealing the multiple modernization of the identity esthetic. The most meaningful effect of the variability is to demonstrate the newspaper's competence in reporting news. Taken together, these two syntagmatic and paradigmatic mechanisms define the essence of the newspaper's identity.

  5. Radiation Physics for Personnel and Environmental Protection

    International Nuclear Information System (INIS)

    Cossairt, J.D.

    1999-01-01

    The Fermi National Accelerator Laboratory FERMILAB- TM- 1834 Fermi National Accelerator Laboratory This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. This manuscript has been authored by Universities Research Association, Inc. under con- tract No. DE- ACO% 76CH03000 with the U. S. Department of Energy. The United States Government and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a nonexclusive, paid- up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for This text is dedicated to my wife Claudia, and our children, Joe and Sally, who provided me with love, cheerfulness, and their support during the long hours spent in the preparation of various versions of this text. I acknowledge the opportunity provided by the Fermilab Director, John Peoples, Jr., to be a part of the U. S. Particle Accelerator School. Also, the encouragement of Mel Month and A. Lincoln Read to teach in the USPAS has been sincerely appreciated. Several members of the Fermilab Environment, Safety and Health Section have greatly assisted me during the

  6. Homenaje al Profesor Académico Juan Di Doménico.

    Directory of Open Access Journals (Sweden)

    Roberto Vergara Támara

    2004-03-01


    Nápoles en 1924 donde completó su bachillerato Académico en el Liceo Umberto 1. Estudió medicina desde 1931 y se graduó en 1937. En 1938 aprobó los exámenes estatales para ejercer la medicina en Italia.

    Casado con Carmen Buraglia Stella (1947-1992. Sus hijos: Juan Francisco, Cirujano y Claudio Maurizio, Arquitecto, constructor. Sus nietos: Stefano, Eric, Claudia y Valeria.
    Viajó a Estados Unidos, se especializó en Cirugía General. Internado Rotatorio en el Merey Hospital Davenport, lowa, 1939-1940. Se matriculó en un Curso de Cirugía General en el Cook County Graduate School of Medicine, 1939-1941 Yen la Mayo Clinic de Rochester, Minnesota. Asistió además al Columbus Hospital de New York y al Charity Hospital de New Orleans...


  7. 6th International Symposium on Molecular Allergology (ISMA

    Directory of Open Access Journals (Sweden)

    Christiane Hilger

    2016-10-01

    -patient quantification of allergen-specific IgE Petra Zavadakova, Aurélie Buchwalder, Fabien Rebeaud, Iwan Märki Symposium 4: Relevance of molecular diagnostics for intervention and treatment O7 Longitudinal analysis of Bet v 1-specific epitope repertoires during birch pollen immunotherapy Barbara Gepp, Nina Lengger, Christian Möbs, Wolfgang Pfützner, Christian Radauer, Barbara Bohle O8 A natural CCD-free tool: is polistes sp. venom suitable for polybia paulista diagnosis and therapy? Karine Marafigo De Amicis, Alexandra Sayuri Watanabe, Clovis Eduardo Galvao, Daniele Danella Figo, Jose Roberto Aparecido Santos-Pinto, Mario Sergio Palma, Fabio Fernandes Morato Castro, Jorge Kalil, Fatima Ferreira, Gabriele Gadermaier, Keity Souza Santos Symposium 5: The advent of molecular allergology in epidemiology O9 Peanut oleosins: from identification to diagnostic testing Christian Schwager, Skadi Kull, Frauke Schocker, Jochen Behrends, Wolf-Meinhard Becker, Uta Jappe O10 Endotypes of oral allergy syndrome in childhood: a molecular diagnostic approach Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Riccardo Asero, Arianna Dondi, Giampaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Andrea Di Rienzo Businco, Annamaria Bianchi, Tullio Frediani, Carmen Verga, Iride Dello Iacono, Diego Peroni, Giuseppe Pingitore, Roberto Bernardini, Paolo Maria Matricardi Symposium 6: Molecular AIT: which approaches will make it to market? O11 Mbc4: an innovative molecule to tackle birch pollen and concomitant food allergies Heidi Hofer, Claudia Asam, Michael Hauser, Peter Briza, Martin Himly, Christof Ebner, Fatima Ferreira O12 Challenges and solutions associated with the production of recombinant Bet v 1 allergen as a therapeutic protein Emmanuel Nony, Maxime Le Mignon, Pierrick Lemoine, Karine Jain, Kathy Abiteboul, Monica Arvidsson, Sabina Rak, Philippe Moingeon Clinical Cases: Breakthroughs and headaches from CRD: interactive session CC1 Anaphylaxis caused by lipid transfer proteins: a

  8. Editorial Editorial

    Directory of Open Access Journals (Sweden)

    José Luiz Aidar Prado

    2008-11-01

    Janotti e Thiago Soares desdobram a metodologia de análise midiática publicidade dita "contra-intuitiva" numa peça publicitária da Fiat. Carolina Sá-Carvalho e Maurício Lissovsky examinam em fotografias as transformações do sofrimento e da dor. Adriana Stürmer e Ada Machado abordam uma série televisiva para estudar produções de sentido identitário de narrativas sobre imigrantes. Maria Lucia Vissoto encara o acontecimento na reportagem jornalística, considerando a questão da tensividade, a partir da semiótica greimasiana. As resenhas desvendam três livros: Cintia dal Bello apresenta O show do eu: a intimidade como espetáculo, de Paula Sibilia, que deve sair em breve, para explicitar a espetacularização do eu em rede; Fernando Resende explica os rumos da coletânea metodologia da pesquisa em jornalismo, organizada por Claudia Lago e Marcia Benetti, que acaba de sair em segunda edição, nem um ano depois de seu lançamento; Laurindo Lalo Leal Filho destrincha políticas de comunicação: buscas teóricas e práticas, coletânea organizada por Murilo Ramos e Suzy dos Santos sobre as políticas de comunicação no país. José luiz Aidar Prado Editor

  9. Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice

    Directory of Open Access Journals (Sweden)

    Dell’Osso B

    2015-07-01

    Full Text Available Bernardo Dell’Osso,1,2,* Umberto Albert,3,* Anna Rita Atti,4 Claudia Carmassi,5 Giuseppe Carrà,6 Fiammetta Cosci,7 Valeria Del Vecchio,8 Marco Di Nicola,9 Silvia Ferrari,10 Arianna Goracci,11 Felice Iasevoli,12 Mario Luciano,8 Giovanni Martinotti,13 Maria Giulia Nanni,14 Alessandra Nivoli,15,16 Federica Pinna,17 Nicola Poloni,18 Maurizio Pompili,19 Gaia Sampogna,8 Ilaria Tarricone,20 Sarah Tosato,21 Umberto Volpe,8 Andrea Fiorillo8 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Bipolar Disorders Clinic, Stanford Medical School, Stanford University, CA, USA; 3Rita Levi Montalcini Department of Neuroscience, University of Turin, Torino, 4Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK; 7Department of Health Sciences, University of Florence, Florence, 8Department of Psychiatry, University of Naples SUN, Naples, 9Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, 10Department of Diagnostic-Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Modena, 11Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, 12Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Federico II of Naples, Naples, 13Department of Neuroscience, Imaging, and Clinical Science, University G.d Annunzio, Chieti-Pescara, 14Section of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 15Psychiatric Institute, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy; 16Bipolar Disorder Unit, CIBERSAM, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain; 17Department of

  10. A contribution to the findings on Hispania Ulterior's coastal societies during the republican and Julio-Claudian period. The log δ in the Tituli Picti of the salsamentum amphorae of Castra Praetoria | Aportación al conocimiento de la sociedad de la costa de la Ulterior en época republicana y Julio-Claudia. El registro ? en los Tituli Picti de las ánforas salsarias de Castra Praetoria

    Directory of Open Access Journals (Sweden)

    Lázaro Lagóstena Barrios

    2005-12-01

    Full Text Available The analysis of several inscriptions preserved on Baetican amphorae of salted fish and fish sauce, which came from the find documented by Dressel in pits of Castra Praetoria, provides an insight into the composition and function of certain sectors of society on the Baetican coast in the first half of the 1st century A.D., and their Republican precedents. The onomastic elements analyzed are characterized by being connected to an activity that was very important for the communities of that time and place: producing and selling processed seafood. | El análisis de ciertos registros epigráficos conservados sobre ánforas béticas de salazones, procedentes del depósito documentado por Dressel en los fosos de los Castra Praetoria, nos permite plantear algunas reflexiones relativas a la composición y función de determinados sectores de la sociedad del litoral bético en la primera mitad del siglo I d.C. y sus precedentes republicanos. Los elementos onomásticos que se analizan tienen la particularidad de hallarse conectados a una actividad de gran importancia en las comunidades de esa época y espacio: la producción y el comercio de alimentos derivados del mar.

  11. Editorial: Qualitative Forschung in der Medienpädagogik

    Directory of Open Access Journals (Sweden)

    Horst Niesyto

    2008-01-01

    Darstellung von Surfwegen im Internet» ein methodisches Instrument vor, das die Autorin nicht als ein technisch komplexes und ‹objektive› Daten lieferndes Methodeninstrumentarium, sondern als eine ergänzende Methode versteht. Gegenstand ihres Forschungsprojekts ist der medienkonvergente Umgang von Jugendlichen mit in Deutschland empfangbaren Musikkanälen und den dazugehörigen Internetseiten. In der Verknüpfung von thematisch fokussierten Interviews (mit erzählgenerierenden Eingangsfragen und gemeinsamen Surfen im Internet (in Verbindung mit der Methode des «lauten Denkens» werden Daten erhoben und anschliessend im Rahmen einer «doppelten Rekonstruktion» ausgewertet. Diese Rekonstruktion umfasst die grafische Visualisierung des Surfwegs der befragten Nutzer/innen. Der Beitrag illustriert das methodische Vorgehen anhand von zwei Beispielen. An der Schnittstelle zwischen mediendidaktischen und schulbezogenen Beiträgen argumentieren die drei Beiträge von Kerstin Mayrberger, Renate Schulz-Zander und Birgit Eickelmann und Claudia Zentgraf u. a. Sie zeigen ein breites Spektrum von möglichen Zugängen zum Schulfeld bzw. zur Erforschung von Schulentwicklungsprozessen aus der Perspektive qualitativer Forschung auf. Renate Schulz-Zander und Birgit Eickelmann gehen von den Ergebnissen der internationalen und nationalen qualitativen IEA-Studie SITES Modul 2 aus und beschreiben nach einem ausführlichen Projektaufriss die Folgeuntersuchung zu SITES M2 eine qualitative und quantitative Studie auf der Basis von Fallstudien. Ziel der Studie ist es, mit den Erhebungsinstrumenten sowohl den Entwicklungsprozess zu rekonstruieren wie die erforderlichen Informationen über den Grad der Nachhaltigkeit der Implementierung zu liefern. In der Anlage verbindet das Projekt quantitative und qualitative Methoden, indem leitfadengestützte Interviews, problemzentrierte Interviews und standardisierte Befragungen mit Fragebögen kombiniert werden. Claudia Zentgraf u. a. fordern in ihrem

  12. Editorial: Theoriebildung in Mediendidaktik und Wissensmanagement

    Directory of Open Access Journals (Sweden)

    Michael Kerres

    2002-10-01

    Full Text Available Das Internet trägt massgeblich zur Entstehung einer neuen Lern- und Wissenskultur bei und ist mittlerweile Gegenstand einer ganzen Reihe von Projekten in der Erziehungswissenschaft. So wird zum Beispiel der Frage nachgegangen, welche Möglichkeiten der Strukturierung und Gestaltung von Lernmaterialien am besten geeignet sind, um Lernprozesse anzuregen, wie die interpersonale Kommunikation im Internet durch didaktische Gestaltungsmassnahmen gefördert werden können oder wie die entfernte Betreuung von Lernenden über das Netz funktioniert. Zunehmend wird dabei auch der Übergang bedeutsam zwischen didaktisch aufbereiteten Lernangeboten, wie sie die Mediendidaktik traditionell beschäftigt, und dem Austausch von nicht didaktisch aufbereiteten Informationen in Organisationen, wie es im Bereich des Wissensmanagements diskutiert wird. In diesen Projekten werden vielfach Detailfragen behandelt, und isoliert, ohne Bezug zu grundlegenden Theoriefragen untersucht. Es mangelt an einer genuin mediendidaktischen Theoriediskussion, die einen übergreifenden Bezugsrahmen aus erziehungswissenschaftlicher Perspektive liefert. In der Vergangenheit ist die Mediendidaktik von Seiten einer «kritischen» Medienpädagogik zeitweise skeptisch beäugt und in ihrer Existenz grundlegend infrage gestellt worden. In der aktuellen Diskussion wird gerne auf lerntheoretische Ansätze zurückgegriffen, die Lernen als aktiven Vorgang der individuellen und kooperativen Wissenskonstruktion begreifen. Doch Wissens- und Lerntheorien ersetzen keine mediendidaktische Modell- und Theoriebildung, die Perspektiven für eine Gestaltung zukünftiger Lernwelten liefert und dabei zum Beispiel sowohl bildungstheoretische Überlegungen als auch Konzepte des instructional design einbezieht. In dem ersten Teil dieser Ausgabe geht es um theoretische Perspektiven der Mediendidaktik. So diskutiert der Artikel von Michael Kerres und Claudia de Witt den Beitrag der Positionen von Behaviorismus

  13. Editorial

    Directory of Open Access Journals (Sweden)

    Irene Machado

    2008-11-01

    Full Text Available As preocupações teóricas que, há dois anos, deflagraram o projeto editorial de Galáxia foram tematizados sob vários pontos de vista nesse número. Desde sua primeira edição, a revista vem defendendo a noção de transdisciplinaridade, seja como forma de abordagem dos diferentes fenômenos da cultura, seja como tema mesmo de várias das intervenções teóricas nela abrigadas. Privilegiar o trânsito entre disciplinas e abordagens, porém, não é um exercí­cio acadêmico. Traduz a compreensão que orienta a abordagem semiótica no tratamento dos produtos da cultura planetária, de suas formas comunicacionais e artí­sticas totalmente mergulhadas nas chamadas novas tecnologias (sistemas digitais, ambientes de rede, realidade virtual, bem como de suas comunidades multiculturais. O exercí­cio transdisciplinar pareceu-nos uma estratégia fundamental para o tratamento de problemas postos na cultura graças ao arrefecimento entre dicotomias ou campos tidos como oponentes. A discussão sobre as relações entre mí­dia e arte inserem-se, com ênfase, nesse novo contexto. Esse é um dos temas inquietantes que está na mente dos pesquisadores e, por isso mesmo, organizou a pauta de discussão deste quarto número de Galáxia. Alguns enfrentamentos sobre o encontro entre arte e mí­dia foram apresentados nos ensaios que compõem o fórum. A intervenção de Arlindo Machado convida o leitor a desfazer equí­vocos: não existe arte que possa prescindir dos meios de seu tempo. Evidentemente sua fala traduz uma linha vigorosa de seu pensamento: a impossibilidade de se pensar comunicação fora do diálogo com as artes e suas linguagens. Ana Claudia de Oliveira enfrentou a tarefa de análise de produções artí­sticas realizadas com os meios e mí­dias de seu tempo para dar conta de um problema caro à comunicação: as estratégias de interação. Embora o foco de seu interesse seja a arte contemporânea, suas idéias confrontam

  14. Book Reviews

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    Redactie KITLV

    2002-01-01

    geschiedenis van de Indisch-Nederlandse dagbladpers, 1744-1905. Amsterdam: Nijgh en Van Ditmar, Leiden: KITLV Uitgeverij, 2001, 862 pp. -Edwin Wieringa, Marijke J. Klokke, Narrative sculpture and literary traditions in South and Southeast Asia. Leiden: Brill, 2000, xiv + 127 pp. [Studies in Asian Art and Archaeology (continuation of: Studies in South Asian Culture 23.] -Catharina Williams-van Klinken, Mark Donohue, A grammar of Tukang Besi. Berlin: Mouton de Gruyter, 1999, xxvi + 576 pp. [Mouton Grammar Library 20.] -Kees Zandvliet, Thomas Suárez, Early mapping of Southeast Asia. Singapore: Periplus Editions, 1999, 280 pp. -Claudia Zingerli, Bernhard Dahm ,Vietnamese villages in transition; Background and consequences of reform policies in rural Vietnam. Passau: Department of Southeast Asian Studies, University of Passau, 1999, xiv + 224 pp. [Passau Contributions to Southeast Asian Studies 7.], Vincent J.H. Houben (eds

  15. Editorial

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    Márcio Matias

    2012-01-01

    Garcia Rosa. Além disto, esta edição também apresenta trabalhos sobre diversos aspectos ligados à comunicação científica, tais como qualidade, visibilidade, indicadores de gestão de fluxo editorial, curadoria digital, repositórios e preservação digital, que são listados a seguir: Metadados de qualidade e visibilidade na comunicação científica, de Silvia Maria Puentes Bentancourt e Rafael Port da Rocha; Indicadores de gestão do fluxo editorial dos periódicos científicos: uma reflexão teórico-metodológica, deElisabete Werlang, Daniela Spudeit e Nadi Helena Presser; O impacto da curadoria digital dos dados de pesquisa na Comunicação Científica de Luana Farias Sales e Luís Fernando Sayão; Análise da dinâmica de evolução das revistas científicas e bibliotecas digitais de teses e dissertações em acesso livre na área de Ciências da Comunicação: o caso do repositório Univerciencia.org, deDalton Lopes Martins e Sueli Mara Soares Pinto Ferreira; Acesso livre via repositórios: politicas de instituições brasileiras, de Tania Chalhub , Alegria Benchimol e Claudia Guerra; O papel das bibliotecas universitárias na comunicação científica: um estudo sobre os repositórios institucionais, de Patrícia dos Santos Caldas Marra; Acesso Livre à Informação Científica em Países em Desenvolvimento: o caso dos Repositórios “Saber” (Moçambique e Digital da UFMG (Brasil, de Ranito Zambo Waete, Maria Aparecida Moura, e Manuel Valente Mangue; SEER e PDF/A na preservação de revistas científicas: relato de experiência, de Ana Paula Araújo Cabral da Silva; Ontologia de dependência tecnológica de documentos digitais: Instrumento de Apoio à Preservação Digital, de Eloi Juniti Yamaoka e Fernando Ostuni Gauthier. Vale também destacar a nossa bela capa gentilmente elaborada pelo professor Adilson Luiz Pinto. Ótima leitura! Márcio Matias e Moisés Lima Dutra Editores – Edição Especial – 3º SBCC – Perspectivas em Acesso Aberto

  16. Editorial

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    Revista Psicoperspectivas

    2008-12-01

    cercano pertenezca a las bases de datos de indexación de revistas académicas, sino que sea reconocida como un referente de publicación de investigaciones y reflexiones teóricas y metodológicas. Agradecemos al Director del Sistema de Biblioteca de la PUCV, Dr. Atilio Bustos González, por su valiosa asesoría.

    Los años de trabajo de los anteriores Editores de la Revista, Sr. Luis Bertoglia (Q.E.P.D. y Dr. Luis Ahumada, nos permiten plantearnos estos nuevos desafíos. En sus inicios, la revista PSICOPERSPECTIVAS fue creada y gestionada como plataforma para mostrar el trabajo de los docentes de la Escuela de Psicología de la Pontificia Universidad Católica de Valparaíso. Hoy, deseamos abrir las puertas y ofrecer un espacio de intercambio de ideas, de producciones y de colaboracio-nes mutuas y lejanas. Por ello, invitamos a la comunidad científica nacional e internacional a presentar sus trabajos en nuestra plataforma.

    El espíritu de lo que REVISTA PSICOPERSPECTIVAS busca está reflejado en esta edición. Los artículos de Luisa Castaldi, de Claudia Perlo, María del Rosario de la Riestra y Leticia Costa, así como el de Paula Ascorra Costa, nos ofrecen perspectivas particulares de posiciona-miento e intervención en temáticas relacionadas con los ámbitos de la Psicología Clínica y Organizacional. El artículo de Nicole Schmal y Pilar Camps es un informe de investigación en el ámbito de la psico-logía jurídica. Por su parte, los artículos de Raquel Ribeiro y de Vicen-te Sisto entregan reflexiones maduradas acerca de los retos de los paradigmas contemporáneos para la Psicología y las Ciencias Sociales en cuanto a la producción de conocimientos y sus consecuencias metodológicas.

    Invitamos, entonces, a los antiguos y futuros lectores a compartir con nosotros este desafío en que hoy nos embarcamos. Bienvenidos a la nueva edición de la REVISTA PSICOPERSPECTIVAS.

    Dra. Verónica López Leiva

  17. Missing links in the root-soil organic matter continuum

    Energy Technology Data Exchange (ETDEWEB)

    O' Brien, Sarah L. [Argonne National Laboratory (ANL); Iversen, Colleen M [ORNL

    2009-01-01

    }]. Rising atmospheric [CO{sub 2}] and other changing environmental factors add a layer of complexity to the quest to understand microbial process. For example, Claudia Boot demonstrated that microbially mediated C and N cycling in Mediterranean California grasslands is intricately linked with summer drought. Ongoing research across subdisciplines seeks to uncover the many complex links between soil organisms of all sizes and the root-SOM continuum. While the role that living organisms play in the transformation of root detritus to SOM is disproportionate to their body size, the nonliving soil environment also influences SOM cycling. However, destructive sampling can obscure feedbacks between abiotic and biotic processes, making it difficult to quantify the role of edaphic factors in the root-SOM continuum.

  18. Editorial L&E, v.7, n.4, 2013

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    Rede Conpadre

    2013-12-01

    cetaceans’ conservation and to the fishers' economic stability as well. In the second article, by Alessandra Carvalho, José Neto, Luciana Moura, Gisele Fernandes, Marilu Figueiredo and Elaine Faria, it is regarded to perform a diagnosis of the soil usage as well as the state of preservation of the water resources of Juqueriquerê River’s watershed, in Caraguatatuba, Estate of Sao Paulo. The analysis of the data allowed the contrast between the degradation areas and the quality of the water resources.  They have stated that safety policies, respect of the soil usage and the proper application of environmental management plans are essential to achieve the sustainable use of the natural resources. Vassiliki Boulomytis and Claudia Alves present in the third article a proper methodology for the assessment of potato plantation areas, taking the short time of procedure into consideration, as the period between the plantation and the harvest occurs in six months the furthest. Considering the availability of LANDSAT medium resolution images, methods for their appropriate classification were used to provide effective target detection for potato plantation areas in the city of Bueno Brandão, Estate of Minas Gerais. The fourth article written by Dante Junior, Geraldo Filho and Maria Seydell presents the potential for wind power generation in the town of Caraguatatuba, Estate of Sao Paulo. The statistical analysis of wind speed has contributed to this evaluation. The authors stated that the average power of the wind speed is favorable to the installation of wind turbines in all seasons. The fifth article presents the research conducted by Beatriz Antoniassi, Nathalie Miranda, Raúl Uribe and Márcia Chaves. They show the analyzes of water from the streams Água Comprida, Vargem Limpa, Ribeirão Vargem Limpa and Bauru River between the center and the industrial district of the city of Bauru, Estate of Sao Paulo. For this comparative analysis, they have conducted a quantitative and

  19. Editorial

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    Adilson Luiz Pinto

    2012-01-01

    agentes maliciosos, com vista a avaliar do uso do sistema em cenários simulados, verificando o potencial de ferramentas e funcionamento autonômico nestas atividades.Na seção de Dissertações e Teses, este número volta a resgatar os esforços dos nossos discentes e de seus respectivos orientadores, que por anos vem recorrendo um caminho promissor, em especial de suas premiações em âmbito nacional, como o estudo de Ana Claudia Perpétuo de Oliveira da Silva, sob a orientação do Professor Dr. Francisco das Chagas de Souza na última edição do ENANCIB/2012.Boa leitura!Adilson Luiz Pinto

  20. EDITORIAL - ARQUIVOLOGIA

    Directory of Open Access Journals (Sweden)

    José Maria Jardim

    2011-01-01

    artigos para este número especial. Convidamos um conjunto de autores que, pela sua diversidade de interesses e inserção institucional, poderiam oferecer ao público interessado reflexões sobre alguns temas de interesse arquivístico. Ao lado de profissionais com carreira consolidada no campo, buscamos viabilizar a participação de arquivistas que estão em construção do seu percurso profissional, aventurando-se pela pós-graduação.A Profa. Angélica Marques, do Curso de Arquivologia da Universidade de Brasília (UnB, oferece-nos um rico estudo sobre temáticas arquivísticas na Ciência da Informação. Diretora do TEAM Brasil no Projeto de pesquisa internacional InterPARES 3, Claudia Lacombe, do Arquivo Nacional, apresenta-nos reflexões sobre a complexa tarefa de tradução do Glossário multilíngue do Projeto InterPARES 3. A Profa. Anna Carla Almeida Mariz, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO, convida-nos ao debate sobre parâmetros para análise de sites de instituições arquivísticas sob a perspectiva da transferência da informação no ambiente da internet e suas demandas ao arquivista. Claudio Muniz Viana, arquivista da Universidade Federal do Estado do Rio de Janeiro (UFRJ, aborda um tema de interesse crescente, os arquivos de arquitetura, a partir da experiência do Núcleo de Pesquisa e Documentação da Faculdade de Arquitetura e Urbanismo da UFRJ. Arquivista da FIOCRUZ, Rose Tenório de Oliveira, apresenta-nos várias correlações entre a inexistência de políticas arquivísticas e a preservação de acervos documentais. O uso da microfilmagem e da digitalização para a preservação e acesso de documentos arquivísticos num contexto de opções tecnológicas à disposição dos arquivistas é contemplado com profundidade pelo Prof. Sérgio Conde de Albite Silva, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO. As professoras Eliana Maria dos Santos Bahia e

  1. Editorial - Arquivologia 10.5007/1518-2924.2011v16nesp1pi

    Directory of Open Access Journals (Sweden)

    José Maria Jardim

    2011-06-01

    contribuíram com artigos para este número especial.Convidamos um conjunto de autores que, pela sua diversidade de interesses e inserção institucional, poderiam oferecer ao público interessado reflexões sobre alguns temas de interesse arquivístico. Ao lado de profissionais com carreira consolidada no campo, buscamos viabilizar a participação de arquivistas que estão em construção do seu percurso profissional, aventurando-se pela pós-graduação. A Profa. Angélica Marques, do Curso de Arquivologia da Universidade de Brasília (UnB, oferece-nos um rico estudo sobre temáticas arquivísticas na Ciência da Informação. Diretora do TEAM Brasil no Projeto de pesquisa internacional InterPARES 3, Claudia Lacombe, do Arquivo Nacional, apresenta-nos reflexões sobre a complexa tarefa de tradução do Glossário multilíngue do Projeto InterPARES 3. A Profa. Anna Carla Almeida Mariz, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO, convida-nos ao debate sobre parâmetros para análise de sites de instituições arquivísticas sob a perspectiva da transferência da informação no ambiente da internet e suas demandas ao arquivista. Claudio Muniz Viana, arquivista da Universidade Federal do Estado do Rio de Janeiro (UFRJ, aborda um tema de interesse crescente, os arquivos de arquitetura, a partir da experiência do Núcleo de Pesquisa e Documentação da Faculdade de Arquitetura e Urbanismo da UFRJ. Arquivista da FIOCRUZ, Rose Tenório de Oliveira, apresenta-nos várias correlações entre a inexistência de políticas arquivísticas e a preservação de acervos documentais. O uso da microfilmagem e da digitalização para a preservação e acesso de documentos arquivísticos num contexto de opções tecnológicas à disposição dos arquivistas é contemplado com profundidade pelo Prof. Sérgio Conde de Albite Silva, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO. As professoras Eliana Maria dos

  2. Sumário/Editorial

    Directory of Open Access Journals (Sweden)

    Comissão Editorial

    2008-11-01

    Full Text Available A revista Galáxia surgiu no cenário intelectual nacional para atestar que a vitalidade das múltiplas confluências entre Comunicação e Semiótica delimitava um campo de conhecimento maduro capaz de produzir a sua própria revista cientí­fica. Fiel ao seu nome - homenagem a Haroldo de Campos, que, em poema homônimo, sinalizava para o conví­vio entre fronteiras -, a revista assumiu sua vocação transdisciplinar. O Programa de Estudos Pós-Graduados em Comunicação e Semiótica da PUC/SP confiou o projeto inicial do periódico a Irene Machado, que respondeu, de forma notável, pela editoria cientí­fica dos sete primeiros números. A dedicação de Irene Machado contribuiu para consolidar a proposta dos trânsitos e fluxos de idéias como fatores de fomento da diversidade que marca a Comunicação como campo cientí­fico. Sem esse competente trabalho, a revista não teria alcançado o significativo patamar Nacional A na escala de avaliação do sistema Qualis/CAPES. Nessa esteira, feita em nome do Programa, os rigores de edição do presente volume ficaram a cargo de uma comissão composta por Lucrécia D'Aléssio Ferrara, Ana Claudia de Oliveira, Eugênio Trivinho e Helena Katz. Galáxia 8 apresenta uma dupla articulação na seção "Fórum". José Luiz Fiorin mostra as contribuições de uma teoria da significação para a compreensão dos fenômenos comunicacionais, que não se restringem ao âmbito da produção de massa. Eric Landowski, por sua vez, chama a atenção para um outro regime de interpretação das encenações do corpo numa detalhada análise ancorada em quatro dimensões especí­ficas do retrato (mimética, hermenêutica, cosmética e estética, na qual a fotografia dos homens polí­ticos na imprensa é tratada como componente de uma estratégia discursiva midiática global. A problematização dessas dimensões possibilita ao autor desenvolver uma teoria semiótica da visualidade midiática. Com essas duas

  3. Clínica de Marly 90 Años de su Fundación

    Directory of Open Access Journals (Sweden)

    Jorge Cavelier Gaviria

    1994-12-01

    . Nacido en el ilustre hogar de Don Nicolás Esguerra Ortiz “El ciudadano perfecto de una era de hombres eximios” al decir del profesor Luis López de Mesa, pertenece así a la llamada generación del 70 que dio brillo sin par a nuestra patria con hombres de la altura de Manuel Murillo Toro, Santiago Pérez, Aquilea Parra, Francisco Javier Zaldúa, Eustorgio Salgar, Salvador Camacho Roldán, Rafael Núñez, Miguel Antonio Caro.

    En 1884, a los 21 años, Carlos Esguerra se gradúa de médico y cirujano para comenzar en el indómito valle del Río Magdalena su ejercicio profesional y continuar estudios de la fiebre amarilla ya iniciados por su tío el Dr. Domingo Esguerra. Pero pronto, a causa de razones políticas abandona el país en unión de su padre con destino a Caracas, donde se recibió de médico de la Universidad Central.

    Luego, cuando los dos viajeros optaron por trasladarse a París, llega a la mitad del tan fecundo decenio de 1880 a 1890, época gloriosa de la medicina francesa. Repasa allí su currículum y observa cómo la medicina hipocrática, llena de imaginación, se despedía para siempre al dar paso a la nueva etapa técnica desarrollada gracias a Luis Pasteur, Roberto Koch, Rodolfo Wirchow, Gregario Mendel, Segismundo Freud, Santiago Ramón y Cajal y Claudia Bernard. Tal vez allí, ideó establecer una casa de salud para pacientes pensionados, cercana a Bogotá y similar a las que funcionaban en las grandes naciones europeas y en los Estados Unidos.

    Por todos los aspectos, la casaquinta Marly, era el sitio ideal para establecer la casa de salud y en esto estuvieron de acuerdo los hermanos Guillermo y Carlos Esguerra, quienes confiaron en el éxito del proyecto.

    Hasta ese momento los enfermos capitalinos eran tratados e intervenidos quirúrgicamente bajo el denominador común de la caridad pública en el vetusto hospital de San Juan de Dios, el cual ocupaba un deteriorado caserón colonial, carente de las indispensables

  4. Obituary: Hugo Schwarz, 1953-2006

    Science.gov (United States)

    Krisciunas, Kevin

    2007-12-01

    , p. 430, 2006). One of the projects well along at the time of his death was a collaboration with David Spergel and a number of REU summer students on the measurement of the polarization of 2,000 stars evenly distributed around this sky. This simple set of data being obtained with the NOT, a telescope Hugo helped make fully functional, will, by a factor of two, improve the sensitivity of experiments such as WMAP and Planck to the detection of gravity waves, one of the holy grails of experimental physics. Because of Hugo's sense of humor, enthusiasm, and perspective, he achieved a good balance between work and play. He could play the diplomat and hobnob with politicians and royalty. He also was proud of the fact that his native language, Dutch, is probably the best language for swearing. He often adopted a Glaswegian accent from his time at university, and would ask you a common question of bartenders there: "So, Jimmy, what's yer name?" He loved fine cigars, particularly the flojos (not-so-tightly rolled ones) from his cigar maker in La Palma, which he generously shared with friends. He loved having people over for barbecues, and would often make paella. Which newspaper was used to cover the large pan was important. It had to be left of center politically, but not too far left. On Hugo's fiftieth birthday a temporary addition was built onto the house, carpeting was laid out on the lawn, and there ensued a sit down dinner for 107 people, complete with live musicians, and many broken glasses. Hugo is survived by his wife Claudia Sanhueza, his two children Tamar and Jouke Schwarz, his step-children Maria Josefina and Diego Gomez, and his half-brother James Schwarz. More than anyone I can think of, he also leaves behind many friends who considered him their best friend.

  5. 7th Young Researcher Meeting

    International Nuclear Information System (INIS)

    2017-01-01

    in an online/offline shared area and exploit the best of both sides” adding a bottom-up approach where “young researchers can now submit their own ideas and research/application projects directly to possible interested companies” . It is mainly based on the Elevator Pitch paradigm, complementary to the traditional top-down approach where companies advertise their openings/research challenges and the interested candidates submit their proposals. This volume consists in a selection of the contributions presented at the conference as either talks or posters. These cover topics in astrophysics and cosmology, particle and theoretical physics, soft and condensed matter, medical physics, quantum information and quantum technologies, and of course metrology. Organising and Editorial Committee Fabio Agostini (fabioagostini31@gmail.com) NAIS Alessio Avella (a.avella@inrim.it) INRiM Rugiada Cuccaro (r.cuccaro@inrim.it) INRiM Marco Di Stefano (marco.distefano@cnag.crg.eu) Centre Nacional d’Anàlisi Genòmica - Centre de Regulació Genòmica (CNAG-CRG) Lapo Lolli (l.lolli@inrim.it) INRiM Lorenzo Pagnanini (lorenzo.pagnanini@gssi.infn.it) Gran Sasso Science Institute Fabrizio Piacentini (f.piacentini@inrim.it) INRiM Emanuela Pusceddu (emanuela.pusceddu@gmail.com) National Research Council-CNR Matteo Serra (matteoserra83@gmail.com) Claudia Antolini (cla.antolini@gmail.com) Giordano Cattani (giordano.cattani@gmail.com) Alessandro Cultrera (a.cultrera@inrim.it) INRiM Giacomo Fragione (giacomo.fragione90@gmail.com) Hebrew University of Jerusalem Marina Migliaccio (migliaccio@asdc.asi.it) ASDC – ASI Science Data Center Enrica Pessana (e.pessana@inrim.it) INRiM Davide Pietrobon (daddeptr@gmail.com) Raffaella Romeo (r.romeo@inrim.it) INRiM Enrico Simonetto (e.simonetto@inrim.it) INRiM Francesco Stellato (francesco.stellato@roma2.infn.it) INFN Roma Tor Vergata Silvia Cavallero (Local Organising Committee) (s.cavallero@inrim.it) INRiM Acknowledgements The organisers of the 7 th

  6. Thousand years of epigraphic culture in Roman Hispania: inscriptions, self-representation and social order | Tausend Jahre epigraphische Kultur im römischen Hispanien: Inschriften, Selbstdarstellung und Sozialordnung

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    Géza Alföldy

    2011-12-01

    representantes del gobierno romano y de los miembros de las élites locales. Con frecuencia se pusieron monumentos sepulcrales, no sólo de los miembros de las capas superiores, sino también de los estratos sociales dependientes de la aristocracia, incluso de sus libertos y esclavos que, como los estratos inferiores de la sociedad romana en general, imitaban los métodos de la autorepresentación de sus dueños. La cultura epigráfica se difundió en época augustea y julio-claudia no solamente en la parte oriental de la Hispania citerior y en la Baetica, es decir, en las zonas de fuerte romanización de la Península Ibérica, sino también en el interior y en el noroeste de Hispania. En época flavia y trajanea tuvo lugar en Hispania una verdadera „explosión epigráfica«: en esta época el número de inscripciones aumentó en muchas ciudades y en sus territorios de un modo sorprendente, y aparecieron nuevos tipos de monumentos epigráficos. En Tarraco, por ejemplo, de las aproximadamente 1.600 inscripciones de la ciudad, sólo unas 100 se fechan en época republicana, augustea y julio-claudia; el resto es posterior, y la mayor parte pertenece a la época flavia y antonina; desde el reinado de Vespasiano se observa, entre otras cosas, la producción en masa de pedestales para estatuas con inscripciones honorarias, anteriormente desconocidas. Se puede hablar casi de una „revolución cultural«. El motivo para este cambio radical del epigraphic habit fue el cambio en la mentalidad de las élites y, siguiendo los comportamientos de ellas, también de grandes masas de las capas inferiores. Para Tácito, Hispania fue ya en época de Tiberio in omnes provincias exemplum; con la proclamación de Galba como emperador se cumplió la antigua profecía de que un día Hispania presentaría al dominus rerum; la extensión del ius Latii a todas las comunidades de Hispania por Vespasiano significó que el país llegó a ser una región casi como Italia; y el ascenso de muchos hispanos

  7. Editorial: Computerspiele und Videogames in formellen und informellen Bildungskontexten

    Directory of Open Access Journals (Sweden)

    Johannes Fromme

    2008-01-01

    zu erproben, wie Computerspiele in den Bereich der aktiven, projektorientierten Medienarbeit eingebunden werden können, die sich dieser neuen Medien – im Unterschied zu Radio, Presse oder Film – bisher kaum angenommen hat. Das Konzept des Video Game Essays knüpft an der Film- und Videoarbeit an, erweitert es aber um einige neue Elemente, die mit den technischen Besonderheiten der Spiele zu tun haben. Der Ansatz kann als innovative Form der Medienanalyse angesehen werden, bleibt aber bei der Analyse nicht stehen, sondern eröffnet auch weitergehende Handlungs- und Lernpotenziale. Als Einsatzgebiete des Video Game Essays werden die ausserschulische Medienarbeit, die Schul- und die Hochschulausbildung genauer betrachtet. Claudia Lampert, Christiane Schwinge und Daniel Tolks zeichnen in ihrem Beitrag die bisherigen Entwicklungen im Bereich der Serious Games nach, die von anderen Ansätzen des mediengestützten Lernens wie E-Learning, Edutainment und Game-Based Learning abgegrenzt werden, und arbeiten den aktuellen Diskussions- und Forschungsstand auf. Die Potenziale und Grenzen werden am Beispiel zweier Spiele aus dem Gesundheitsbereich (Games for Health detaillierter diskutiert, für die auch erste empirische Befunde vorliegen. Serious Games gewinnen zwar – nach Ansicht der Autoren/innen vor allem aus Marketinggründen – zunehmend an Bedeutung, allerdings bestehe noch ein erheblicher Forschungs- und Evaluationsbedarf. Sabrina Schrammel und Konstantin Mitgutsch kritisieren, dass im medienpädagogischen Diskurs über Computerspiele der Umstand vernachlässigt werde, dass Spielen eine kulturell geprägte, aktive Auseinandersetzung mit einem Spielgegenstand sei. Ihnen geht es im vorliegenden Beitrag daher darum, die spezifische medial- kulturelle Praktik des Computerspielens zu erfassen bzw. dafür einen geeigneten methodischen und theoretischen Zugang zu entwickeln und vorzustellen. Das Spielen von Computerspielen wird in Anlehnung an den internationalen Diskurs

  8. Certain Verbs Are Syntactically Explicit Quantifiers

    Directory of Open Access Journals (Sweden)

    Anna Szabolcsi

    2010-12-01

    .Stechow, A. von. 2009. ‘Syntax and semantics: an overview’. To appear in: Maienborn, Claudia et al. (eds., Semantics: An International Handbook of Natural Language Meaning. Berlin: Mouton de Gruyter.Steedman, M. 1988. ‘Combinators and Grammars’. In R. Oehrle, E. Bach & D. Wheeler (eds. ‘Categorical Grammars and Natural Language Structures’, 417–442. Dordrecht.Steedman, M. 2000. The Syntactic Process. Cambridge, MA: The MIT Press.Stowell, T. 1995a. ‘The Phrase Structure of Tense’. In J. Rooryck & L. Zaring (eds. ‘Phrase Structure and Lexicon’, 277–291. Dordrecht: Kluwer.Stowell, T. 1995b. ‘What Do the Present and Past Tenses Mean?’ In P. Bertinetto et. al. (ed. ‘Temporal Reference, Aspect, and Actionality. Vol. 1: Semantics and Syntactic Perspectives’, 381–396. Torino: Rosenberg and Sellier.Szabó, Z. G. 2011. ‘Bare quantifiers’. Philosophical Review 120: 247–283.Szabolcsi, A. 1987. ‘Bound variables in syntax (are there any?’. In J. Groenendijk et. al. (ed. ‘Sixth Amsterdam Colloquium’, 331–351. Amsterdam: Institute for Language,Logic, and Information.Szabolcsi, A. 1992. ‘Combinatory grammar and projection from the lexicon’. In I. A. Sag & A. Szabolcsi (eds. ‘Lexical Matters. CSLI Lecture Notes 24’, 241–269. Stanford, CSLI Publications.Szabolcsi, A. 2009a. ‘Overt nominative subjects in infinitival complements cross-linguistically’.http://www.nyu.edu/gsas/dept/lingu/nyuwpl/.Szabolcsi, A. 2009b. ‘Overt nominative subjects in infinitival complements in Hungarian’. In M. den Dikken & V. Robert (eds. ‘Approaches to Hungarian 11’, 251–276. Amsterdam: John Benjamins.Szabolcsi, A. 2010. Quantification. Cambridge: Cambridge University Press.Yanovich, I. 2009b. ‘How Much Expressive Power Is Needed For Natural Language Temporal Indexicality?’ In L. D. Beklemishev & R. de Quieroz (eds. ‘Proceedings of Logic,Language, Information and Computation’, 293–309. 18th International Workshop, WoLLIC 2011

  9. Digital Storytelling – Special issue

    Directory of Open Access Journals (Sweden)

    Yngve Nordkvelle

    2010-11-01

    Full Text Available Since the inception of Seminar.net the phenomenon of Digital Storytelling has often been suggested as a promising genre for teaching and learning in a variety of areas. Academically, the genre has attracted interest from scholars in media studies, political science, social work, health and education. In this issue we have sought attention from a huge number of academically inclined persons who either use the genre to teach with media, for teaching and learning about media, or studying how this specific way of working with media offers new possibilities for the articulation of the voice of the common people.When we invited authors for this special issue we did so expecting – and hoping for – contributions from a wide field of interests. We have landed 11 different manuscripts and have organised them according to a tentative order of themes they address: “Teaching and learning with Digital Storytelling”, “Community building”, “Genres of communication” and “Practical papers”.  Being a journal for lifelong learning, the educational use has gained the most interest. But also emerging new areas of use related to health, leisure, recreation, activism, community building, planning, professional communication, and reflection are reflected in the papers. We think the contributions together support our efforts for building the knowledge about digital storytelling as a genre and its potential in the media society. Scholarly publications in this field are generally mediated on paper. And there has been no shortage of superb exemplars of scholarly work these last couple of years: Story Circle: Digital Storytelling around the World, edited by John Hartley and Kelly McWilliams and Digital Storytelling, Mediatized Stories: Self-representations in New Media, edited by Knut Lundby, as well as a conference report, “Storytelling – Reflections in the Age of Digitalization” edited by Yvonne Gächter, Heike Ortner, Claudia Scwartz, Andreas

  10. 32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016.

    Science.gov (United States)

    Langsteger, W; Rezaee, A; Loidl, W; Geinitz, H S; Fitz, F; Steinmair, M; Broinger, G; Pallwien-Prettner, L; Beheshti, M; Imamovic, L; Beheshti, M; Rendl, G; Hackl, D; Tsybrovsky, O; Steinmair, M; Emmanuel, K; Moinfar, F; Pirich, C; Langsteger, W; Bytyqi, A; Karanikas, G; Mayerhöfer, M; Koperek, O; Niederle, B; Hartenbach, M; Beyer, T; Herrmann, K; Czernin, J; Rausch, I; Rust, P; DiFranco, M D; Lassen, M; Stadlbauer, A; Mayerhöfer, M E; Hartenbach, M; Hacker, M; Beyer, T; Binzel, K; Magnussen, R; Wei, W; Knopp, M U; Flanigan, D C; Kaeding, C; Knopp, M V; Leisser, A; Nejabat, M; Hartenbach, M; Kramer, G; Krainer, M; Hacker, M; Haug, A; Lehnert, Wencke; Schmidt, Karl; Kimiaei, Sharok; Bronzel, Marcus; Kluge, Andreas; Wright, C L; Binzel, K; Zhang, J; Wuthrick, Evan; Maniawski, Piotr; Knopp, M V; Blaickner, M; Rados, E; Huber, A; Dulovits, M; Kulkarni, H; Wiessalla, S; Schuchardt, C; Baum, R P; Knäusl, B; Georg, D; Bauer, M; Wulkersdorfer, B; Wadsak, W; Philippe, C; Haslacher, H; Zeitlinger, M; Langer, O; Bauer, M; Feldmann, M; Karch, R; Wadsak, W; Zeitlinger, M; Koepp, M J; Asselin, M-C; Pataraia, E; Langer, O; Zeilinger, M; Philippe, C; Dumanic, M; Pichler, F; Pilz, J; Hacker, M; Wadsak, W; Mitterhauser, M; Nics, L; Steiner, B; Hacker, M; Mitterhauser, M; Wadsak, W; Traxl, A; Wanek, Thomas; Kryeziu, Kushtrim; Mairinger, Severin; Stanek, Johann; Berger, Walter; Kuntner, Claudia; Langer, Oliver; Mairinger, S; Wanek, T; Traxl, A; Krohn, M; Stanek, J; Filip, T; Sauberer, M; Kuntner, C; Pahnke, J; Langer, O; Svatunek, D; Denk, C; Wilkovitsch, M; Wanek, T; Filip, T; Kuntner-Hannes, C; Fröhlich, J; Mikula, H; Denk, C; Svatunek, D; Wanek, T; Mairinger, S; Stanek, J; Filip, T; Fröhlich, J; Mikula, H; Kuntner-Hannes, C; Balber, T; Singer, J; Fazekas, J; Rami-Mark, C; Berroterán-Infante, N; Jensen-Jarolim, E; Wadsak, W; Hacker, M; Viernstein, H; Mitterhauser, M; Denk, C; Svatunek, D; Sohr, B; Mikula, H; Fröhlich, J; Wanek, T; Kuntner-Hannes, C; Filip, T; Pfaff, S; Philippe, C; Mitterhauser, M; Hartenbach, M; Hacker, M; Wadsak, W; Wanek, T; Halilbasic, E; Visentin, M; Mairinger, S; Stieger, B; Kuntner, C; Trauner, M; Langer, O; Lam, P; Aistleitner, M; Eichinger, R; Artner, C; Eidherr, H; Vraka, C; Haug, A; Mitterhauser, M; Nics, L; Hartenbach, M; Hacker, M; Wadsak, W; Kvaternik, H; Müller, R; Hausberger, D; Zink, C; Aigner, R M; Cossío, U; Asensio, M; Montes, A; Akhtar, S; Te Welscher, Y; van Nostrum, R; Gómez-Vallejo, V; Llop, J; VandeVyver, F; Barclay, T; Lippens, N; Troch, M; Hehenwarter, L; Egger, B; Holzmannhofer, J; Rodrigues-Radischat, M; Pirich, C; Pötsch, N; Rausch, I; Wilhelm, D; Weber, M; Furtner, J; Karanikas, G; Wöhrer, A; Mitterhauser, M; Hacker, M; Traub-Weidinger, T; Cassou-Mounat, T; Balogova, S; Nataf, V; Calzada, M; Huchet, V; Kerrou, K; Devaux, J-Y; Mohty, M; Garderet, L; Talbot, J-N; Stanzel, S; Pregartner, G; Schwarz, T; Bjelic-Radisic, V; Liegl-Atzwanger, B; Aigner, R; Stanzel, S; Quehenberger, F; Aigner, R M; Marković, A Koljević; Janković, Milica; Jerković, V Miler; Paskaš, M; Pupić, G; Džodić, R; Popović, D; Fornito, M C; Familiari, D; Koranda, P; Polzerová, H; Metelková, I; Henzlová, L; Formánek, R; Buriánková, E; Kamínek, M; Thomson, W H; Lewis, C; Thomson, W H; O'Brien, J; James, G; Notghi, A; Huber, H; Stelzmüller, I; Wunn, R; Mandl, M; Fellner, F; Lamprecht, B; Gabriel, M; Fornito, M C; Leonardi, G; Thomson, W H; O'Brien, J; James, G; Hudzietzová, J; Sabol, J; Fülöp, M

    2016-04-01

    Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O LangerA12 Outcome prediction of temporal lobe epilepsy surgery from P-glycoprotein activity. Pooled analysis of (R)-[11C]-verapamil PET data from two European centresM Bauer, M Feldmann, R Karch, W Wadsak, M Zeitlinger, MJ Koepp, M-C Asselin, E Pataraia, O LangerA13 In-vitro and in-vivo characterization of [18F]FE@SNAP and derivatives for the visualization of the melanin concentrating hormone receptor 1M Zeilinger, C Philippe, M Dumanic, F Pichler, J Pilz, M Hacker, W Wadsak, M MitterhauserA14 Reducing time in quality control leads to higher specific radioactivity of short-lived radiotracersL Nics, B Steiner, M Hacker, M Mitterhauser, W WadsakA15 In vitro 11C-erlotinib binding experiments in cancer cell lines with epidermal growth factor receptor mutationsA Traxl, Thomas Wanek, Kushtrim Kryeziu, Severin Mairinger, Johann Stanek, Walter Berger, Claudia Kuntner, Oliver LangerA16 7-[11C]methyl-6-bromopurine, a PET tracer to measure brain Mrp1 function: radiosynthesis and first PET evaluation in miceS Mairinger, T Wanek, A Traxl, M Krohn, J Stanek, T Filip, M Sauberer, C Kuntner, J Pahnke, O LangerA17 18F labeled azidoglucose derivatives as "click" agents for pretargeted PET imagingD Svatunek, C Denk, M Wilkovitsch, T Wanek, T Filip, C Kuntner-Hannes, J Fröhlich, H MikulaA18 Bioorthogonal tools for PET imaging: development of radiolabeled 1,2,4,5-TetrazinesC Denk, D Svatunek, T Wanek, S Mairinger, J Stanek, T Filip, J Fröhlich, H Mikula, C Kuntner-HannesA19 Preclinical evaluation of [18F]FE@SUPPY- a new PET-tracer for oncologyT Balber, J Singer, J Fazekas, C Rami-Mark, N Berroterán-Infante, E Jensen-Jarolim, W Wadsak, M Hacker, H Viernstein, M MitterhauserA20 Investigation of Small [18F]-Fluoroalkylazides for Rapid Radiolabeling and In Vivo Click ChemistryC Denk, D Svatunek, B Sohr, H Mikula, J Fröhlich, T Wanek, C Kuntner-Hannes, T FilipA21 Microfluidic 68Ga-radiolabeling of PSMA-HBED-CC using a flow

  11. EDITORIAL: Student undergraduate laboratory and project work

    Science.gov (United States)

    Schumacher, Dieter

    2007-05-01

    will be the typical learning environment for physics students in the future. However, the details of this change should be based on a better understanding of the learning process in a students' lab. A deeper insight is given by the contribution of Claudia von Aufschnaiter and Stefan von Aufschnaiter in 'University students' activities, thinking and learning during laboratory work'. A second important alteration has taken place in physics education during the last decade. The so-called new media have changed the world of learning and teaching to an unprecedented extent. Learning with new media is often much more related to physics labwork than to traditional lectures or seminars (e.g. small learning groups, problem based learning, a high level of interactivity). We need to take these new tools into consideration as suitable amendment (blended learning) or substitution (e-learning, distance learning) of labwork courses. The developments with presumably the highest impact on physics education are modelling tools, interactive screen experiments and remote labs. Under 'modelling tools', all computer programs are summarized which enable the simulation of a physical process based on an explicit or implicit given formula. Many commercial program packages are available. The application of modelling tools in labwork courses permits a tight binding of theory and experiment. This is particularly valid and necessary in the case of project work. An interactive screen experiment (ISE) is a computer assisted representation of a physical experiment. When watching a video clip of an experiment students are forced to be passive observers. In the case of an ISE they can manipulate the setup on the screen with the help of a hand-like mouse pointer and the computer will show the appropriate result. The ISE consists of a large number of digital photos taken from the real experiment. From an epistemological point of view an ISE has the character of an experiment and can be used to discover or

  12. Resumos dos Trabalhos Apresentados em Painéis no Workshop Baía de Guanabara, IGEO/UFRJ - 2002

    Directory of Open Access Journals (Sweden)

    2003-01-01

    matéria orgânica, estando a mesma, intercalada por lentes de areia, sobre um solo residual sobreposto ao embasamento cristalino. Conclui-se então, que os solos estudados, constitui-se de uma argila orgânica que apresenta um alto poder de sorção, o que viabiliza o processo de remediação natural. Agradecimentos: Petroflex Ind. & Com. S.A. Registros Palinológicos em Depósitos Quaternários da Praia Vermelha, Urca-RJ Robson Lucas Bartholomeu, Dept. Geologia UFRJ Ortrud Monika Barth, FIOCRUZ Marcia Aguiar de Barros, Dept. Geologia UFRJ Claudia Gutteres Vilela, Dept. Geologia UFRJ Laboratório de Palinologia, Departamento de Geologia, IGEO/UFRJ. Prédio CCMN, Bloco J, Sala J2-019, Cidade Universitária, Ilha do Fundão, CEP 21.949-900. Rio de Janeiro, RJ. E-mail: rlucasbr@yahoo.com.br O presente trabalho tem como objetivo conhecer a evolução da vegetação e do meio ambiente na Praia Vermelha, Urca, Rio de Janeiro, evidenciando as modificações na paisagem através da identificação de tipos polínicos caracterizadores de formações vegetais e ambientes. 144 Anuário do Instituto de Geociências - UFRJ Volume 26 / 2003 Foram selecionados sedimentos provenientes de um perfil estratigráfico obtido através de uma trincheira aberta no pós-praia, em trecho da Praia Vermelha, Urca, RJ, datados na base em 4520 +/- 80 anos antes do presente (A.P. Os sedimentos foram coletados com o auxílio de canaletas, com 45 cm de comprimento, 2,5 cm de largura e 2 cm de profundidade e blocos indeformados, utilizados nas análises sedimentológicas. Os resultados das análises palinológicas indicam na base do depósito o domínio da vegetação de Mata Atlântica, que gradualmente foi substituída por uma vegetação mais aberta, de campo. Os níveis da turfa inferior apresentam o predomínio dos tipos polínicos Schinus e Alchornea, característicos de Mata Atlântica e/ou de várzeas úmidas de formações secundárias. Os níveis da areia lamosa apresentam o domínio de

  13. Editorial

    Directory of Open Access Journals (Sweden)

    Gildenir Carolino Santos

    2012-12-01

    , RS, brings attention to a conceptual overview that emphasizes the importance of knowing the school reality as an element for school reorganization. Also, points out the use of institutional assessment as a subsidy for this reflexivity and for rearticulating actions. It situates public policies in different contexts, highlighting the practice as a locus of bureaucratic insubordination, in which counter regulation processes emerge, while the efforts of different actors of educational setting are articulated.A contribution from Mercosur, the third article, by Ana Maria Fernández Caraballo (Faculty of Psychology UdelaR, with the title "The academic tutorial in higher education: the case of UdelaR" deals with the ‘tutorial’ as it is classically used in university contexts - which is different from other tutorials of a pedagogical nature. This "academic tutorial" results from the knowledge production, unique effect of wisdom and ties between the tutor and the pupil. The focus is the tutoring at the University of the Republic (UdelaR.The following article, "Special education: distance pedagogical practices in teacher’s formation for Specialized Education Services (SES", where Ana Claudia Pavão Siluk and Sílvia Maria de Oliveira Pavão, both from the Federal University of Santa Maria, analyze the dimensions of teaching methodology, evaluative criteria and the theoretical assumptions from which a Course of Specialized Educational Services-SES, is structured."Printed Instructional materials for distance education: interfaces with the language practices", the fifth article, written by Michele Rodrigues de Albuquerque and Ivanda Maria Martins Silva, teachers of Federal Rural University of Pernambuco, analyzes the production of printed educational material for distance education (EAD - understanding distance education as a model in which students and teachers are physically separated, but joined together virtually through technological and pedagogical resources. It also

  14. 5th National Congress of the Italian Society of Physiotherapy

    Directory of Open Access Journals (Sweden)

    Alessandro Aina

    2016-10-01

    controlled pilot trial of hand robotic training compared with a sensory-motor training program in post stroke patients Violini Claudia, Cenci Marco Joseph, Delconte Carmen, Pisano Fabrizio P48 Critical Illness PolyNeuroMyopathy (CIPNM: chance for a good prognosis Youssef S, Montesano M, Picardi M, De Giampaulis P, Corbo M, Pisani L. P49 The EdUReP approach plus manual therapy for the management of insertional Achilles tendinopathy: a case study Zanetta Anna, Garzonio Fabiola, Ruella Carolina, Sartorio Francesco

  15. El proyecto “Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease” (CHICAMOCHA: 15 años construyendo un activo institucional de la Universidad Autónoma de Bucaramanga-UNAB / Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas Disease Project. CHICAMOCHA: 15 Years Building an Asset for The Universidad Autónoma de Bucaramanga-UNAB / O Projeto Cardiovascular Investigação de Saúde e colaboração para avaliar os marcadores e resultados da doença de Chagas CHICAMOCHA: 15 anos construindo um ativo institucional na Universidade Autônoma de Bucaramanga-UNAB

    Directory of Open Access Journals (Sweden)

    Juan Carlos Villar-Centeno, MD., Esp., MSc., PhD

    2015-07-01

    Full Text Available El 3 de mayo del año 2000 asistió a una oficina de la entonces naciente Facultad de Medicina de la Universidad Autónoma de Bucaramanga (UNAB, quien fuera el primer participante de un proyecto llamado “Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease” (CHICAMOCHA. Su estudio piloto, planeado para un año, fue financiado por el departamento de ayudas a la comunidad de ECOPETROL (a través de un convenio con el ISABU, firmado por el entonces director, el actual decano de la facultad, Dr. Juan José Rey. El apoyo dado por el director de investigaciones de la UNAB, Dr. Germán Oliveros, y el decano en la época, Dr. Juan Carlos Mantilla encontró un rector dispuesto, el Dr. Gabriel Burgos Mantilla, que equiparó el apoyo económico con el del patrocinador externo. Con ese soporte, bajo la coordinación del Dr. Luis Ángel Villar, el equipo de trabajo inicial (Víctor Mauricio Herrera, médico, Martha Vásquez, enfermera y Claudia Ríos, secretaria inició este proyecto. CHICAMOCHA fue concebido para que – estudiando donantes de sangre con pruebas de tamización positivas o negativas para Trypanosoma cruzi en una relación 1:4 – se sirvieran dos propósitos: El primero era facilitar el estudio del diagnóstico temprano de la cardiomiopatía de Chagas, por comparación con su contraparte de seronegativos; el segundo, a mayor plazo, era construir una cohorte de adultos jóvenes clínicamente sanos. Esto permitiría, luego de varios años de observación, contribuir al estudio de la enfermedad cardiovascular de origen aterosclerótico y sus factores de riesgo, como aporte al conocimiento de las enfermedades crónicas no transmisibles (ECNT en nuestro medio. En esta editorial haremos énfasis en la segunda meta, cumplida más de una década después. Luego de varios intentos por superar las dificultades logísticas, se logra conseguir financiación de Colciencias para reevaluar los

  16. only: A Case Study In Projective Meaning

    Directory of Open Access Journals (Sweden)

    Craige Roberts

    2010-12-01

    and Semantics, Vol. 11, Academic Press, NY.Kratzer, A. 1980. ‘The notional category of modality’. In H. J. Eikmeyer & H. Reiser (eds. ‘Words, Worlds and Contexts’, 38–74. de Gruyter, Berlin.Kratzer, A. 1989. ‘An investigation of the lumps of thought’. Linguistics and Philosophy 12, no. 5: 607–653.http://dx.doi.org/10.1007/BF00627775Lewis, D. 1969. Convention: A philosophical study. Harvard University Press.Lewis, D. 1973. Counterfactuals. Blackwell Publishers, Oxford.McCawley, J. D. 1981. Everything that Linguists Have Always Wanted to Know about Logic But Were Ashamed to Ask. University of Chicago Press.Partee, B. H. 1996. ‘Allegation and Local Accommodation’. In B. H. Partee & P. Sgall (eds. ‘Discourse and Meaning: Papers in Honor of Eva Hajicová’, 38–74. John Benjamins, Amsterdam.Potts, C. 2005. The Logic of Conventional Implicatures. Oxford University Press.Potts, C. to appear. ‘Conventional implicature’. In Claudia Maienborn, Klaus von Heusinger & Paul Portner (eds., Semantics: An international handbook of natural language meaning. Berlin, New York: Mouton de Gruyter.Roberts, C. 1987. Modal Subordination, Anaphora, and Distributivity. Ph.D. thesis, University of Massachusetts at Amherst.Roberts, C. 1989. ‘Modal Subordination and Pronominal Anaphora in Discourse’. Linguistics and Philosophy 12: 683–721.http://dx.doi.org/10.1007/BF00632602Roberts, C. 1996a. ‘Information Structure: Towards an integrated theory of formal pragmatics’. In H. Yoon & A. Kathol (eds. ‘OSU Working Papers in Linguistics 48’, 91–136. The Ohio State University. To appear with a new Afterword in Semantics and Pragmatics.Roberts, C. 1996b. ‘Anaphora in intensional contexts’. In Shalom Lappin (ed. ‘Handbook of Semantics’, 215–246. Blackwell.Roberts, C. 2004. ‘Discourse context in dynamic interpretation’. In Laurence Horn & Gregory Ward (eds. ‘Handbook of Contemporary Pragmatic Theory’, 197–220. Blackwell.Roberts, C. 2006.

  17. Editorial 32

    Directory of Open Access Journals (Sweden)

    Nylza Offir García Vera

    2011-12-01

    ón educativa para personas con discapacidad desde una posición que vincula tales procesos a las condiciones de posibilidad para una vida digna y con justicia social.De otra parte, las investigaciones acerca de los procesosde inclusión de estudiantes sordos a una institución educativa ofrecen también un panorama diverso de las condiciones no sólo físicas y materiales sino también pedagógicas, didácticas, disciplinares y contextuales que requiere esta educación inclusiva. Así lo reconocen tanto Pablo Salazar, Rita Flórez y Clemencia Cuervo ?a partir de las estructuras y prácticas organizacionales escolares que nos presentan? como el grupo Conocimiento profesionaldel profesor de Ciencias, que analiza estas mismas condiciones de inclusión en la educación superior, de manera específica en la Licenciatura en Biología de la Universidad Pedagógica Nacional.Desde la línea de las mediaciones e incorporación de las TIC en educación, dos reflexiones interpelan los ámbitos pedagógico y político de la educación virtual en nuestro país: la dimensión pedagógica como una reflexiónpendiente –tesis de Claudia Rozo– y la pregunta por las políticas que subyacen a este tipo de educación, aunada a la esfera política del ser humano –planteamientocentral del artículo de Diana Sáenz–. Por su parte, Myriam Leguízamo y Omar López examinan la relación existente entre el logro académico obtenido, por estudiantes de secundaria, en la interacción con un ambiente hipermedia sobre operadores tecnológicos y la formulación de metas de aprendizaje auto-impuestas y metas de aprendizaje asignadas.Conforman también este número un avance de la investigaciónen torno a la didáctica de la imagen ofrecida por Rafael Barragán y Wilson Gómez y una investigación culminada acerca del éxito en la Enseñanza de las CienciasBasada en Indagación (ECBI, un modelo aplicado en el marco del Programa Pequeños Científicos en la ciudad de Ibagué; el grupo de investigaci

  18. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

    Directory of Open Access Journals (Sweden)

    Cristian-Mihail Niculae

    2016-11-01

    ța in the period 01 January 2014–30 June 2016. Epidemiological considerations. Iulia Gabriela Șerban, Ghiulendan Resul, Consuela Marcaș A47 Acute liver failure with favorable evolution in an HIV-HBV coinfected patient Iosif Marincu, Patricia Poptelecan, Bogdan Trincă, Sorina Mitrescu, Anca Tudor, Daliborca Vlad, Livius Tirnea A48 Lifestyle impact on HIV management Nurcan Baydaroglu, Alina Cristina Neguț, Oana Săndulescu, Daniela Manolache, Gabriela Ceapraga, Monica Andreea Stoica, Anca Streinu-Cercel, Adrian Streinu-Cercel 49. HIV positive mothers newborns - clinical experience from January 2012 to June 2016 Carmen Manciuc, Mariana Pagute, Cristina Nicolau, Carmen Dorobăț, Alexandra Largu A50 Rediscovering HIV-associated progressive multifocal leukoencephalopathy and HIV encephalopathy: clinical suspicion and subsequent brain autopsies Ioan-Alexandru Diaconu, Laurențiu Stratan, Daniela Ion, Luciana Nichita, Cristina Popescu, Raluca Năstase, Daniela Munteanu, Violeta Molagic, Cătălin Tilișcan, Mihaela Rădulescu, Alexandra Diaconu, Anca Negru, Alina Orfanu, Cristina Dragomirescu, Remulus Catană, Anca Leuștean, Irina Duport-Dodot, Cristina Murariu, Iulia Bodoșca, Violeta Niță, Alexandra Badea, Victoria Aramă A51 Antenatal surveillance of pregnant women with risk behavior and its impact on mother-to-child HIV transmission in Romania Mariana Mărdărescu, Cristina Petre, Marieta Iancu, Rodica Ungurianu, Alina Cibea, Ruxandra Drăghicenoiu, Ana Maria Tudor, Delia Vlad, Sorin Petrea, Carina Matei, Dan Oțelea, Carmen Crăciun, Cristian Anghelina, Alexandra Mărdărescu A52 Noninvasive assessments (APRI, Fib-4, transient elastography of fibrosis in patients with HIV and HIV/HBV infection Elena Dumea, Adrian Streinu-Cercel, Sorin Rugină, Lucian Cristian Petcu, Stela Halichidis, Simona Claudia Cambrea A53 Undetectable HIV viral load – the main goal in the management of HIV-infected patients Carmen Chiriac, Nina-Ioana Bodnar, Iringo-Erzsebet Zaharia

  19. Programa de Pós-Graduação em Geologia - Teses Defendidas 1998 - Doutorado - Instituto de Geociências - Universidade Federal do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    1998-01-01

    distância, no Morro da Fome. No estado do Rio de Janeiro, temos o sítio arqueológico de Itaboraí, no município do mesmo nome. O sítio está inserido em uma rampa de colúvio situada nos bordos da Bacia Calcária de São José de Itaboraí. 123 Anuário do Instituto de Geociências - UFRJ Volume 21 / 1998 A partir da década de 70 foram utilizados os métodos da relação silte-argila, ferro (Fe livre - ferro (Fe cristalizado, estratigráfico, tipológico e o da correlação geomorfológica (manchas climáticas. O método tipológico revelou uma cadeia tecnológica na confecção dos artefatos cobrindo as técnicas usadas em outras partes do mundo, indo do Pleistoceno Inferior ao Superior, reforçando os resultados obtidos pelos outros métodos relativos. O método absoluto do C14 foi usado à superfície do sítio. Apresentaram-se, também, as vantagens do estudo das manchas climáticas sobre os artefatos para avaliação cronológica. Finalmente, procurou-se através da apresentação dos três casos acima expostos, evidenciar a contribuição do arqueólogo aos estudos do Quaternário. Quanto às pinturas rupestres, sublinhou-se sua validade na interpretação paleoambiental a partir de representações pictóricas de animais pleistocênicos, especialmente em canhões. Utilizou-se o método etnológico-etnográfico para o reconhecimento - a partir de pinturas sobre rochas - de antigas migrações, tomando-se por base mitos, planos cosmológicos, uso de alucinógenos, etc., próprios do grupo lingüístico Tukâno. Essas conclusões foram reforçadas por registros históricos e por estudos no campo da Paleontologia Humana. Finalmente, apresentaram-se dois casos em que o homem préhistórico utilizou extensamente rochas para deixar registrado seu conhecimento astronômico e sua maneira particular de tentar uma integração com o cosmos. Nome: Claudia Guterres Vilela Título: Foraminíferos Quaternários da Plataforma Continental Norte Brasileira e do Leque do

  20. SINFONI Opens with Upbeat Chords

    Science.gov (United States)

    2004-08-01

    the development of SINFONI for nearly 7 years. Some of the members of the Commissioning Teams are depicted in PR Photos 24g/04 and 24h/04; in addition to the SPIFFI team members present on the second photo, Walter Bornemann, Reinhard Genzel, Hans Gemperlein, Stefan Huber have also been working on the reintegration/commissioning in Paranal. Notes [1] This press release is issued in coordination between ESO, the Max-Planck-Institute for Extraterrestrial Physics (MPE) in Garching, Germany, and the Nederlandse Onderzoekschool Voor Astronomie in Leiden, The Netherlands. A German version is available at http://www.mpg.de/bilderBerichteDokumente/dokumentation/pressemitteilungen/2004/pressemitteilung20040824/index.html and a Dutch version at http://www.astronomy.nl/inhoud/pers/persberichten/30_08_04.html. [2] The SINFONI team consists of Roberto Abuter, Andrew Baker, Walter Bornemann, Ric Davies, Frank Eisenhauer (SPIFFI Principal Investigator), Hans Gemperlein, Reinhard Genzel (MPE Director), Andrea Gilbert, Armin Goldbrunner, Matthew Horrobin, Stefan Huber, Christof Iserlohe, Matthew Lehnert, Werner Lieb, Dieter Lutz, Nicole Nesvadba, Claudia Röhrle, Jürgen Schreiber, Linda Tacconi, Matthias Tecza, Niranjan Thatte, Harald Weisz (Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany), Anthony Brown, Paul van der Werf (NOVA, Leiden, The Netherlands), Eddy Elswijk, Johan Pragt, Jan Kragt, Gabby Kroes, Ton Schoenmaker, Rik ter Horst (ASTRON, Dwingeloo, The Netherlands), Henri Bonnet (SINFONI Project Manager), Roberto Castillo, Ralf Conzelmann, Romuald Damster, Bernard Delabre, Christophe Dupuy, Robert Donaldson, Christophe Dumas, Enrico Fedrigo, Gert Finger, Gordon Gillet, Norbert Hubin (Head of Adaptive Optics Dept.), Andreas Kaufer, Franz Koch, Johann Kolb, Andrea Modigliani, Guy Monnet (Head of Telescope Systems Division), Chris Lidman, Jochen Liske, Jean Louis Lizon, Markus Kissler-Patig (SINFONI Instrument Scientist), Jerome Paufique, Juha Reunanen

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