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Sample records for giovanna scarel claudia

  1. Interview with Claudia Roden

    OpenAIRE

    Mac Con Iomaire, Máirtín

    2016-01-01

    Claudia Roden is an award winning cookbook writer and cultural anthropologist based in the United Kingdom. She is co-chair with Paul Levy of the Oxford Symposium on Food and Cookery. She was born in 1936 in Cairo, Egypt. After completing her formal education in Paris, she moved to London to study at Saint Martin's School of Art. She began her career as a painter, but soon realised following the Suez Crisis that the Jewish food culture of Egypt was disappearing which led her to begin her study...

  2. I dolori di Claudia Seeliger

    Directory of Open Access Journals (Sweden)

    Uta Treder

    2015-01-01

    Full Text Available La protagonista di questo romanzo dice “io”, si confida con noi, ci conduce attraverso la sua rocambolesca vicenda tenendoci avvinti e costringendoci ad esserle complici. Più di una volta restiamo col fiato sospeso, ci sentiamo a tratti confusi e smarriti, scuotiamo la testa disapprovando le sue scelte avventate, ma non ce la sentiremmo mai di abbandonarla al suo destino. Troppo forte è la sua personalità, perfino laddove scopre il suo lato fragile, troppo coinvolgente la sua passione, troppo disarmante la sua intelligenza. Non c’è niente da fare: Claudia Seeliger ci tiene in pugno. Claudia Seeliger, o chi per lei, bisognerebbe dire… In questo romanzo poliziesco, psicologico, erotico, politico, interculturale e intertestuale, Uta Treder si rivela narratrice sapiente, colta, ma anche ironica e assai irriverente. Profilo biograficoUta Treder (Amburgo 1943 – Firenze 2013 è stata professore ordinario di Storia della cultura tedesca a Firenze e di Letteratura tedesca a Trieste e a Perugia. Da germanista si è occupata di autori quali Goethe, Schiller, Hölderlin, Novalis, Heine, Droste-Hülshoff, Fontane, Keller, Lasker-Schüler, Kafka, Bachmann, Mayröcker. Il suo principale interesse ha riguardato la letteratura delle donne che sono state "dimenticate" dal Canone. Come autrice di narrativa ha pubblicato la raccolta di racconti Luna Aelion (München 1989 e i romanzi Die Alchemistin (Frankfurt a.M. 1993, Die Bäume von Babelsberg (Pfalzfeld 2005, audiolibro letto da Petra Pawel, 2007; anticipazione italiana in "LEA", 1-2004, Der Schwarze König (Pfalzfeld 2007. È stata socia fondatrice della Società Italiana delle Letterate. I dolori di Claudia Seeliger è la prima traduzione italiana dell'opera narrativa di Uta Treder.

  3. Developmental hip dysplasia in the Medici family: Giovanna from Austria (1548-1578) and her daughter Anna (1569-1584).

    Science.gov (United States)

    Giuffra, Valentina; Fornaciari, Gino

    2013-01-01

    The skeletal remains of Giovanna from Austria (1548-1578), first wife of the Grand Duke of Tuscany Francesco I (1541-1587), and their daughter Anna (1569-1584) were exhumed from the Medici Chapels in the Basilica of S. Lorenzo in Florence and submitted to anthropological and paleopathological study. The superior portion of the acetabulum of Giovanna is sloping, and reveals bilateral acetabular dysplasia. The same defect is also present in Anna, together with sacral spina bifida occulta. In both women the anatomical abnormality is limited to a deformation in the roof of both acetabulae and the femoral heads continued to articulate normally within the hip joint. The presence of bilateral acetabular dysplasia in the skeletal remains of Giovanna and her daughter Anna can be explained by a series of risk factors to which the two Medici women were exposed: female sex, practice of swaddling in the first months of life, as well as scoliosis and pelvic deformity for Giovanna and family history for Anna.

  4. Enrico Biasin - Giovanna Maina - Federico Zecca (Eds., Porn After Porn. Contemporary Alternative Pornographies

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    Mirko Lino

    2015-05-01

    Full Text Available Dopo Il Porno Espanso, recensito a suo tempo su Between, il nuovo libro a cura di Enrico Biasin, Giovanna Maina e Federico Zecca, Porn After Porn, è il primo tassello di un'interessante collana, “Mapping Pornographies: Histories, Geographies, Cultures”, che ha l'obiettivo di fornire materiali e strumenti metodologici al dibattito scientifico sulla pornografia contemporanea.I contributi che compongono il volume, dai saggi prettamente accademici alle testimonianze di artisti, produttori e registi del porno, creano tra loro fitte geometrie tematiche che illustrano i corpi, gli usi dei new media, gli sguardi e i consumi delle pornografie alternative, dalla loro proliferazione in Rete alla democratizzazione dell'accesso ai piaceri visivi inscritti nella fruizione di contenuti hard-core a pubblici non esclusivamente maschili ed eterosessuali.

  5. Claudia Quinta (Pro Caelio 34 and an altar to Magna Mater

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    Eleanor Winsor Leach

    2010-11-01

    Full Text Available Among the items of sculpture from the Capitoline collection now housed in the Museum of the Power Station Montemartini is a marble relief altar of the Claudian Period (E. Simon's dating dedicated to the mater deorum and the navis salvia and depicting the arrival of the goddess Cybele at Rome by ship. The dedicator is one Claudia Syntyche and the sculpture alludes to the legends attached to a much honored woman of the Claudian family whom Cicero, in his oration pro Caelio brought on stage in a cameo appearance to bolster his case against the controversial contemporary woman Clodia Metelli as one of the accusers of his client M. Caelius Rufus. This paper will consider questions raised by the iconography of the altar with reference to the development of Claudia's legend in Roman mythology and subsequently ask who was this Claudia the dedicator and why did she choose Magna Mater for her vow?

  6. "Maailma naised" on humanistlik kunstiprojekt / Claudia DeMonte ; interv. Reet Varblane

    Index Scriptorium Estoniae

    DeMonte, Claudia

    2004-01-01

    Ameerika kunstnik Claudia DeMonte, kelle kuraatoriprojekt "Maailma naised" ja isiknäitus "Retrospektiiv" on 23. I-22. II avatud Tallinna Kunstihoones. Kunstnikust, loomingust ja kuraatoriprojektist, feministlikust kunstist, naiste positsioonist USA-s, rahvusvahelisest naiste muuseumist San Franciscos, Katrin Pere tööst jm.

  7. Rupture on the Brazilian documentary photography: Claudia Andujar and the poetry of the (invisible

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    Rafael Castanheira Pedroso de Moraes

    2014-07-01

    Full Text Available This article aims to analyse Claudia Andujar’s photographies from her books Yanomami and The vulnerability of being not only to reflect about their conceptual characteristics that mix social engagement and personal expression, but also to identify the photographer’s technical and aesthetic choices to document the invisible phenomenons of the Yanomami’s culture. Using innovatives strategies of representation, Andujar reached inedited results from the political and aesthetic points of view, which marked a break with the Brazilian documentary photography history.

  8. Loomepõhine uurimistöö - mida see tähendab? / Claudia Pasquero ; intervjueerinud Veronika Valk

    Index Scriptorium Estoniae

    Pasquero, Claudia, 1974-

    2016-01-01

    Aprilli alguses peeti Eesti Kunstiakadeemia Arhitektuuriteaduskonnas ADAPT-r päeva, kus arutleti loomepõhise uurimistöö metodoloogia üle. Esinejate seas oli ka Londoni Ülikooli kolledži Bartlett`i Arhitektuurikooli õppejõud Claudia Pasquero. Intervjuus ta selgitab oma seisukohti loomepõhise doktorantuuri kohta linnaehituses ja arhitektuuris

  9. The Art of ATLAS; multimedia installation by Neal Hartman and Claudia Marcelloni at Thinktank science museum in Birmingham, UK.

    CERN Multimedia

    Claudia Marcelloni

    2010-01-01

    The Art of ATLAS is an multimedia installation, developed by Neal Hartman and Claudia Marcelloni about the physicists, engineers and technicians behind the ATLAS Experiment. The installation will been shown at Planetarium entrance of the Thinktank science museum in Birmingham, UK from October 2010 until January 2011.

  10. O JARDIM DE SI: o imaginário de CLAUDIA ROQUETTE-PINTO

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    Antonio Rediver Guizzo

    2014-12-01

    Full Text Available A lírica de Claudia Roquette-Pinto encontra no ambiente do jardim, simulacro miniaturizado do mundo natural, as imagens que compõem a representação simbólica do conflito surgido entre o eu e o mundo, e intensa reflexão metapoética. As imagens recorrentes da queda, da flor, da escuridão e do corpo que enformam a materialidade simbólica de Roquette-Pinto revelam uma lírica constituída em uma zona de transição, estabelecida entre saturação da ordem social orientada pelo aproveitamento racional do mundo e pela dominação da natureza, e a insurgência pós-moderna de uma ordem ecológica, na qual se privilegia a fruição mais livre do presente. A abordagem metodológica escolhida para adentrar a lírica de Claudia Roquette-Pinto orienta-se a partir da teoria das estruturas antropológicas do imaginário proposta por Gilbert Durand conjuntamente com as reflexões sobre a sociedade contemporânea presentes na obra do sociólogo Michel Maffesoli. Na primeira e segunda seção do artigo, apresentam-se brevemente considerações sobre o imaginário e o estruturalismo figurativo de Gilbert Durand; na terceira seção analisa-se um pequeno recorte da lírica de Roquette-Pinto.

  11. House, a feminine noun: representating architectural spaces in Casa e Jardim and Casa Claudia in age the great magazines

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    Rafael Alves Pinto Junior

    2011-12-01

    Full Text Available The emergence of magazines focusing on architecture and aimed at the general public, such as Casa e jardim in the 1950s and Casa Claudia in the 1970s, represented the creation of a culture of living associated with domestic spaces and the values this space represents as a typological object after the second half of the 20th century. Among other things, it affirmed the values of the social roles of women and architecture as the depository of the attributes of privacy and intimacy: the locus of family, memory and affection. The magazines set the tone for representing the architectural space as an area for living, legitimizing behaviors while exercising an aesthetic pedagogy, ushering in a culture associated with living and establishing a source for imagined ways of building in Brazil. By affirming an image of civilization, both Casa e jardim and Casa Claudia became a benchmark for other periodicals devoted to this theme.

  12. Infrared Power Generation: Study in an Insulated Compartment

    Science.gov (United States)

    2015-08-17

    Utter, and G. Scarel, "Determining a mathematical model for a voltage-induced, exclusively temporal soliton ". (Oral) 2015 Undergraduate Research...33) JMU Technical point of contact: Dr. Giovanna Scarel (Principal Investigator - PI) - Dr. Brian C. Utter (Co-PI) JMU, Department of Physics and... physics , astronomy and geology, biology and medicine and art, are discussed. Technolosically. 1 the primary objective of this Project is to

  13. La ri-codificazione corporea nella Commedia dell'Arte di Claudia Contin

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    Riccardo Benfatto

    2010-12-01

    Full Text Available Abstract – IT Questo articolo è il frutto di una tesi di Laurea triennale in Antropologia dello Spettacolo. In particolare viene analizzato il percorso che Claudia Contin e Ferruccio Merisi hanno compiuto per giungere ad una ricodificazione corporea delle Maschere della Commedia dell'Arte. Attraverso lo studio dei documenti disponibili, sia scritti che di tipo iconografico, i due artisti si soffermano dapprima sul personaggio di Arlecchino per poi espandere la ricerca a tutti i restanti Caratteri. Lo scopo è quello di ritrovare la struttura archetipica di ogni personaggio della Commedia dell'Arte, cioè di trasformare ogni atteggiamento psicologico, e quindi soggettivo, in atteggiamento corporeo, più universale. Diventa quindi fondamentale la costruzione di una maschera corporea che possa tradurre in deformazioni fisiche quelle caratteristiche che i personaggi di Commedia dell'Arte si trascinano da secoli. Ciò richiede un enorme lavoro sul corpo dell'attore, il quale deve letteralmente indossare questa maschera corporea prima ancora della maschera di cuoio. Il viaggio nel mondo di Arlecchino si compone di molteplici tappe che arricchiscono ciascuna la qualità del lavoro, così ché si evidenzieranno in alcuni personaggi tratti di codificazioni provenienti da altre culture. Ecco che, per esempio, elementi del Kathakali e delle Tarante del “nostro” Sud possono convivere con sereno conflitto all'interno di uno stesso Carattere. Si tratta di acquisire precisione da chimico affinché si renda possibile la reazione tra sostanze profondamente diverse. Il lavoro più che ventennale dell'attrice friulana ha portato alla costituzione di un linguaggio diverso per ogni Carattere, linguaggio insegnabile, trasmissibile e codificato. In una parola: duraturo. Abstract – EN This article is the result of an undergraduate thesis in Anthropology of the Show. Particularly, it analyzes the path covered by Claudia Contin and Ferruccio Merisi to reach a

  14. Goldin ja Katz meeste ning naiste palgalõhest / Claudia Goldin, Lawrence Katz ; toimetanud Steven D. Levitt, Stephen Dubner

    Index Scriptorium Estoniae

    Goldin, Claudia

    2010-01-01

    Harvardi ülikooli tööturu uurimisele spetsialiseerunud majandusteadlased ning meeste ja naiste palgalõhe teema spetsialistid Claudia Goldin ja Lawrence Katz vastavad küsimustele, mis puudutavad võrdse haridusega meeste ja naiste tegelikku palgaerinevust, palgalõhet meeste ja naiste vahel siis, kui mitte arvestada tööaega, naiste suutlikkust pidada palgaläbirääkimisi ning tegevusalasi, kuhu peaksid mehed ja naised pürgima või mida vältima

  15. Stuccos and roman concretes of the Baelo Claudia city (Cádiz: Characterization and causes of decay

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    Puertas, Francisca

    1994-12-01

    Full Text Available This paper presents the study of the nature and conservation state of different stuccos and Roman concretes from the Roman city of Baelo Claudia (Cádiz. The chemical, mineralogical and microstructural compositions of the said materials have been established. Different causes of their decay have been found, among which we should emphasize the loss of the binding material (lime, basically due to the processes of partial solubilization; the lack of bond between the stuccos and the support stone, due to the different characteristics and properties of these two materials; and finally, the biological-type attack with the proliferation and colonization of different organisms in the said materials.

    Se ha estudiado la naturaleza y estado de conservación de distintos estucos y hormigones romanos procedentes de la ciudad romana de Baelo Claudia (Cádiz. Se ha establecido la composición química, mineralógica y microestructural de dichos materiales. Se han encontrado diferentes causas de su deterioro. Entre ellas, cabe destacar la pérdida del material ligante (cal, fundamentalmente motivado por procesos de solubilización parcial; la falta de adherencia entre los estucos y la piedra soporte, debido a las diferentes características y propiedades de ambos materiales; y finalmente, también al ataque de tipo biológico, con la proliferización y colonización de distintos organismos en dichos materiales.

  16. Ancient earthquakes in the Roman city of Baelo Claudia (Cadiz, South of Spain): Fifteen years of archaeosimology research

    Energy Technology Data Exchange (ETDEWEB)

    Silva, P.G.; Giner-Robles, J.L.; Reicherter, K.; Rodriguez-Pascua, J.L.; Gruetzner, C.; Garcia-Jimenez, I.; Carrasco Garcia, P.; Bardaji, T.; Santos, G.; Roquero, E.; Roez, J.; Perucha, M.A.; Perez-Lopez, R.; Fernandez Macarro, B.; Martinez-Grana, A.; Goy, J.L.; Zazo, C.

    2016-07-01

    This work illustrates the state of the art on archaeoseismology of the ancient Roman city of Baelo Claudia (Tarifa, Cádiz) after nearly fifteen years of research. This ancient Roman site was affected by two earthquakes in the years AD 40–60 and AD 260–290 which promoted important urban and architectural changes and eventually the destruction and further abandonment of the city in AD 365–390. Earthquake Archaeoseismological Effects (EAEs) are catalogued, described and mapped in the entire monumental sector of the city mainly witnessing the last earthquake which occurred in AD 260–290. Mapping of oriented EAEs illustrate damage distribution all over the lower sector of the city, as well as the occurrence of suspect coseismic landslide and tsunami events. The structural analysis of oriented EAEs throughout the entire mapped sector suggests that the intervening ground motion was preferentially oriented in a SW to NE direction. The geoarchaeological analysis and some relevant archaeological anomalies, strongly suggest the occurrence of coeval tsunami events during both ancient earthquakes, pointing to the occurrence of an offshore seismic source SSW of the city. Several N-S normal faults have been identified around the Bolonia Bay area and some of them continue offshore SSW of Baelo Claudia. These faults with clear Quaternary activity can be considered as the more probable seismic sources for the events affecting the ancient Roman site and they are consistent with the mapped damage orientation displayed by the structural analysis of EAEs within the old Roman city. (Author)

  17. O trabalho de Claudia Andujar a partir de uma história da fotografia engendrada por meandros discursivos institucionais

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    Carolina Soares

    Full Text Available resumo Este texto resgata a produção fotográfica de Claudia Andujar do final dos anos de 1950 e início de 1960 - ainda anterior ao trabalho que viria a desenvolver com os Yanomami - para uma análise que leve em consideração a dimensão do assunto escolhido; o resultado visual de sua representação e a forma de circulação do trabalho. Ao enfatizar esses aspectos, o objetivo é entender de que modo a estética desenvolvida pela artista em questão é contaminada e assim constituída por critérios discursivos alinhados a uma história da fotografia forjada por mecanismos institucionais.

  18. Towards a reconstruction of the contributions of the Argentine experience to the development of International Human Rights Law: the voices of Claudia Fontes and Paula Bombara

    OpenAIRE

    Estefanía Giaccone; Viviana Kühne; Agustina Vázquez

    2017-01-01

    In the present dissertation, we intend to relate and contrast the representations that emerge from legal and political-institutional discourses on the crime of forced disappearance of persons in the Argentinian historical experience. In this sense, we will analyze the representations of the crime of forced disappearance of persons in two artistic works: The Reconstruction of Pablo Miguez Portrait, Claudia Fontes’ sculpture, and The Sea and the Serpent, a novel by Paula Bombara, in order to re...

  19. Towards a reconstruction of the contributions of the Argentine experience to the development of International Human Rights Law: the voices of Claudia Fontes and Paula Bombara

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    Estefanía Giaccone

    2017-12-01

    Full Text Available In the present dissertation, we intend to relate and contrast the representations that emerge from legal and political-institutional discourses on the crime of forced disappearance of persons in the Argentinian historical experience. In this sense, we will analyze the representations of the crime of forced disappearance of persons in two artistic works: The Reconstruction of Pablo Miguez Portrait, Claudia Fontes’ sculpture, and The Sea and the Serpent, a novel by Paula Bombara, in order to read them into the perspective of law, with the jurisprudence and communications of international organizations that shape our unit of study.

  20. Elements of Yanomami identity in the photographs of Cláudia Andujar Elementos de identidade cultural Yanomami nas fotografias de Claudia Andujar

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    Miguel Luiz Contani

    2006-12-01

    Full Text Available Considering that it is through the concept of index, that plastic and meaningful characteristics of certain issues are revealed, it is assumed that approaching photography to cultural identity matters might be a wise procedure. This paper is aimed at analyzing pictures shot by photographer Claudia Andujar among the Yanomami, in the 1970’s to find out, through semiotic aesthetic approaches, how such images convey some elements of those Indians’ cultural identity. Tendo em conta o conceito de índice, em que características plásticas e significativas de um determinado recorte se revelam, parte-se do pressuposto de que aproximar fotografia e questões de identidade cultural pode tornar-se um rico procedimento. Este artigo se propõe analisar fotografias realizadas junto aos Yanomami, na década de 1970 pela fotógrafa Claudia Andujar, a fim de compreender, por meio da abordagem estética da semiótica, a presença, nessas imagens, de elementos de identidade cultural daqueles índios.

  1. Culto a los ancestros en época romana: los cipos funerarios de las necrópolis de Baelo Claudia (Bolonia, Cádiz

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    Jiménez Díez, Alicia

    2007-12-01

    Full Text Available A quite large number of proposals have been published about the meaning of a singular group of pieces (termed ‘dolls’ at the beginning of the twentieth century found in association with different tombs in the necropoleis of Baelo Claudia. In this paper I suggest we can only understand the funerary cippi of Bolonia within a wider ritual context that places these sculptures in relation with cult to ancestors (that are seen and represented as a community where individuals can not be differentiated not only in the tomb, but also in domestic and sanctuary contexts.Se han publicado propuestas muy diversas para explicar la función de un singular conjunto de piezas (bautizadas como “muñecos” a principios del siglo XX que se hallaron asociadas a distintos enterramientos de las necrópolis de Baelo Claudia. En el presente estudio se propone entender los cipos funerarios de Bolonia dentro de un contexto ritual más amplio que permite relacionarlos con el culto a los ancestros (concebidos y representados como una comunidad de carácter indiferenciado, no sólo en la tumba, sino también en ambientes domésticos y en santuarios.

  2. From “Modern Woman” to “Liberated Woman.” An Analysis of the Magazine Claudia de México (1965-1977

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    Karina Felitti

    2017-12-01

    Full Text Available This article analyzes the women’s magazine Claudia de México from its first appearance in 1965 up until 1977, when the National Family Planning Program was launched. Claudia presented itself as a magazine for the “modern woman,” with fashion tips, recipes and articles that addressed sexual and reproductive issues such as sexual pleasure, birth control and abortion. Starting in the 1970s, slogans of “women’s liberation” made their appearance and, though they were criticized, they nevertheless marked the beginning of a new era in which demographic policy began to uphold the rights of women to make decisions on reproductive issues and in which “machismo” became something to be eliminated. This article examines this transition, combining an in-depth analysis of the magazine’s contents (articles, photographs, advertising with other sources, such as contemporary films, Second Wave feminist writings, interviews with women who came of age in those years and secondary literature examining the period.

  3. FONSECA, Claudia; ROHDEN, Fabiola & MACHADO, Paula Sandrine (orgs.). 2012. Ciências na vida: antropologia da ciência em perspectiva

    OpenAIRE

    Castro, Rosana

    2018-01-01

    O livro Ciências na vida: antropologia da ciência em perspectiva, organizado por Claudia Fonseca, Fabiola Rohden e Paula Sandrine Machado, é resultante de seminário homônimo, realizado em agosto de 2011, na Universidade Federal do Rio Grande do Sul. Além de antropólogas(os) brasileiras(os), pesquisadoras(es) oriundos da França, da Inglaterra, da Alemanha, da Grécia e de Portugal assinam a autoria dos quatorze capítulos que compõem a coletânea, denotando, já de início, tanto a abrangência do i...

  4. Espejel Carvajal Claudia, La justicia y el fuego. Dos claves para leer la Relación de Michoacán

    OpenAIRE

    Michelet, Dominique

    2014-01-01

    Il est des ouvrages sur lesquels il n’est jamais trop tard pour attirer l’attention des lecteurs, au-delà des cercles des spécialistes qui, eux, en connaissent ou, au moins, en supputent les mérites dès avant leur parution. Tel est le cas de cette somme que Claudia Espejel a su tirer de sa thèse de doctorat, soutenue en 2004 au Centre d’études historiques du Colegio de Michoacán. La Relación de Michoacán – ou, plus exactement, la Relación de las cerimonias y rictos y población y gobernación d...

  5. Formas de ocio en la antigua Roma: desde la dinastía Julio-Claudia (Octavio Augusto hasta la Flavia (Tito Flavio Domiciano

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    Maximiliano Korstanje

    2008-01-01

    Full Text Available Basados en una mitología netamente política (helénica y poseedores de recursos estratégicos favorables, los romanos se convirtieron en una de las civilizaciones dominantes de su tiempo. En este sentido, muchos investigadores dedicados al turismo, actualmente, han investigado los orígenes y las formas de ocio en la antigua Roma, aunque de manera superficial y muy general. El objetivo del presente trabajo es profundizar sobre las formas de ocio en la Roma Imperial durante las dinastías Julio-Claudia y Flavia, para así poder explicar cuál era la relación del ocio, como institución, con el poder político de la época.

  6. Imágenes de sobrevivencia: del realismo urbano del Grupo Chaski al Perú contemporáneo de Claudia Llosa

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    Jorge Zavaleta Balarezo

    2018-01-01

    Full Text Available El artículo analiza los trabajos iniciales del Grupo Chaski y de Claudia Llosa, dos puntos de referencia en el cine peruano contemporáneo. A través de la crítica al argumento y las características de las películas de estos cineastas, se construye una imagen del Perú, un país que volvió a la democracia en 1980 y, desde entonces, ha sido gobernado por presidentes posteriormente acusados de corrupción y abuso de poder como Alan García, Alberto Fujimori, Alejandro Toledo y Ollanta Humala. Las películas de Chaski inciden en la pobreza y vulnerabilidad de niños enfrentados a la gran ciudad, Lima, y se anticipan a ese cine de la marginalidad que en los años 90 produjo cintas tan logradas como Pizza, birra, faso, La vendedora de rosas, Ciudad de Dios o Ratas, ratones, rateros. La obra de Claudia Llosa, por su parte, llamó la atención internacional por el triunfo de su segunda película, La teta asustada, en el Festival de Berlín. Esta película, que marca una continuidad respecto de la primera, Madeinusa, es un retrato de los años posteriores a la guerra interna, los de la barbarie de Sendero Luminoso y la respuesta de las Fuerzas Armadas. El artículo aspira a ofrecer una mirada global de la sociedad peruana de los últimos treinta años, marcados por la pobreza estructural, el terrorismo, la aplicación de reformas neoliberales y la corrupción a todo nivel del estado.

  7. BAELO CLAUDIA Y POLLENTIA: NUEVAS EVIDENCIAS SOBRE LAS FLUCTUACIONES ECONÓMICAS EN LA HISPANIA ROMANA DE LOS SIGLOS I-II D. C. (Baelo Claudia and Pollentia: new evidence on the economic fluctuations in Roman Spain during the first and second centuries AD

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    Pascual Izquierdo-Egea

    2012-06-01

    Full Text Available La revisión cronológica de la necrópolis sureste de Baelo Claudia (Bolonia-Tarifa, Cádiz y la de Can Fanals, en Pollentia (Alcudia, Mallorca, ha permitido ampliar el conocimiento sobre las fluctuaciones económicas en la Hispania romana de los siglos I y II de nuestra era y los cambios sociales asociados a las mismas. Se ha obtenido una nueva confirmación del impacto de la gran crisis de tiempos de Tiberio en los registros funerarios de Baelo Claudia y Pollentia, detectada previamente en Ampurias o Emporiae (Gerona. La bonanza de la época de Claudio se puede comprobar en Baelo Claudia de forma más elocuente que en Emporiae. Ahora bien, esta coincidencia en el devenir económico se rompe a lo largo de la segunda mitad del siglo I d. C., en concreto durante el periodo comprendido entre Nerón y principios de los Flavios. Es entonces cuando, frente a la decadente Ampurias, una pujante Pollentia sigue los pasos de la opulenta Baelo mostrando su mayor prosperidad. Sin embargo, esas tres ciudades romanas de Hispania mantienen un claro nexo basado en la exhibición durante ese periodo de su máxima complejidad social. Siempre se da una proporción directa entre la acumulación económica amortizada en los ajuares y la diferenciación entre los individuos, salvo en dos casos excepcionales. Uno, ya conocido, se refiere a la Ampurias de la segunda mitad del siglo I d. C., donde el empobrecimiento que la caracteriza se asocia con un incremento de la distancia social. Y, el otro, corresponde al extraño fenómeno documentado en la Pollentia del siglo II d. C. En esta sigue creciendo el gasto funerario, pero la diferenciación social medida desciende durante la primera mitad hasta caer abruptamente a lo largo de la segunda parte de dicha centuria. No obstante, lo más importante es que, por ahora, se detecta la misma evolución de la diferenciación social en Emporiae, Baelo Claudia y Pollentia desde la época de Tiberio hasta la primera mitad del

  8. AS REPRESENTAÇÕES DO CORPO NA LÍRICA DE CLAUDIA ROQUETTE-PINTO SOB O OLHAR DE ZYGMUNT BAUMAN E MICHEL MAFFESOLI

    Directory of Open Access Journals (Sweden)

    Antonio Rediver Guizzo

    2014-12-01

    Full Text Available Neste trabalho, analisamos a representação da sociedade contemporânea através das relações entre corpo, ser e sociedade presentes na lírica de Claudia Roquette-Pinto, obra constituída em uma zona de fronteira entre saturação da ordem social moderna econômica, orientada pelo aproveitamento planejado dos recursos e pela dominação da natureza, e a insurgência pós-moderna de uma ordem ecológica, na qual se privilegia a fruição destes recursos no presente. Para tal fim, orientamo-nos através do diálogo entre dois horizontes teóricos distintos: a contraposição entre o corpo moderno e o corpo pós-moderno, investigada na obra do sociólogo polonês Zygmunt Bauman; e a associação entre ética e estética característica da pós-modernidade e seus desdobramentos sobre as relações com o corpo, analisada na obra do sociólogo francês Michel Maffesoli.

  9. I dolori di Claudia Seeliger

    OpenAIRE

    Uta Treder

    2015-01-01

    La protagonista di questo romanzo dice “io”, si confida con noi, ci conduce attraverso la sua rocambolesca vicenda tenendoci avvinti e costringendoci ad esserle complici. Più di una volta restiamo col fiato sospeso, ci sentiamo a tratti confusi e smarriti, scuotiamo la testa disapprovando le sue scelte avventate, ma non ce la sentiremmo mai di abbandonarla al suo destino. Troppo forte è la sua personalità, perfino laddove scopre il suo lato fragile, troppo coinvolgente la sua passione, troppo...

  10. Unustatud katakombid / Claudia Haj Ali

    Index Scriptorium Estoniae

    Haj Ali, Claudia

    1999-01-01

    Arheoloog Jean-Yves Empereur leidis Egiptuse Aleksandria linna lähedal asuvasse kaljusse rajatud katakombid, mis on osa hellenistlikul perioodil rajatud ning pikka aega unustuse hõlmas olnud surnute linnast. Leidude seas on kipsist Meduusa pea nind leide Rooma perioodist.

  11. Crescere errando: minori immigrati non accompagnati" (Clara Silva - Giovanna Campani

    Directory of Open Access Journals (Sweden)

    Olivia Salimbeni

    2005-12-01

    Full Text Available La presenza in Italia di minori immigrati non accompagnati è un fenomeno recente e tuttavia in forte crescita. Questo testo raccoglie i risultati di quella che potremmo definire la seconda di tre tappe di una ricerca europea incentrata sullo studio del fenomeno dei minori immigrati non accompagnati, avviata nel 2000 e da poco terminata. L’indagine è stata svolta nel quadro di finanziamento del 'Programma Daphne' della Commissione Europea e ha riguardato nelle prime due fasi tre realtà europee, Italia, Germania e Finlandia e nella terza altre realtà quali il Portogallo, la Spagna, la Francia e la Grecia.

  12. ¿Nuevos sujetos subalternos? ¡No en la nación cercada! Del “Informe sobre Uchuraccay” de Mario Vargas Llosa a Madeinusa de Claudia Llosa

    Directory of Open Access Journals (Sweden)

    Juan Carlos Ubilluz Raygada

    2014-06-01

    Full Text Available Madeinusa (2006, la ópera prima de Claudia Llosa, es una de las películas peruanas más exitosas en el exterior; ha ganado festivales de cine en Europa y Estados Unidos. Pero también es la película que ha suscitado uno de los debates más candentes en el medio nacional. El debate gira en torno a la representación del mundo andino y de sus habitantes. A fin de entender el porqué de su carácter encendido, dediquemos de entrada algunas líneas al espacio y al tiempo de la película.

  13. Claudia Demattè and Alberto del Río, Parodia de la materia caballeresca y teatro áureo. Edición de Las aventuras de Grecia y su modelo serio, el «Don Florisel de Niquea» de Montalbán

    Directory of Open Access Journals (Sweden)

    Javier Guijarro Ceballos

    2015-01-01

    Full Text Available Review of Claudia Demattè and Alberto del Río, Parodia de la materia caballeresca y teatro áureo. Edición de Las aventuras de Grecia y su modelo serio, el «Don Florisel de Niquea» de Montalbán, Servicio de Publicaciones de la Universidad de Navarra (Publicaciones digitales del GRISO, Pamplona, 2012, 247 pp. ISBN: 9788480813365.

  14. Rezension von: Thomas Martinec, Claudia Nitschke (Hg.: Familie und Identität in der deutschen Literatur. Frankfurt am Main u.a.: Peter Lang Verlag 2009. — Ariane Eichenberg: Familie – Ich – Nation. Göttingen: V&R unipress 2009.

    Directory of Open Access Journals (Sweden)

    Christine Kanz

    2010-06-01

    Full Text Available Die Themen Generation und Familie gehören zu den wichtigsten Sujets literarischer Texte, insbesondere wenn diese die Herausbildung oder die Zerstörung von Identität problematisieren. Ein neuer, von Claudia Nitschke und Thomas Martinec herausgegebener Tagungsband ist der literatur- und kulturwissenschaftlichen Auseinandersetzung mit diesen Themen gewidmet. Sechs Jahrzehnte nach dem Ende des Zweiten Weltkrieges hat vor allem das Genre des Generationenromans Hochkonjunktur, insbesondere Texte der dritten Generation zum Umgang der Großeltern-Generation mit dem Nationalsozialismus. Den Verfasser/-innen dieses neuen, in sich heterogenen Genres wird in der Studie von Ariane Eichenberg allerdings keine allzu große Wirkmächtigkeit bescheinigt. Im Gegenteil nährten die modischen Texte mit den Funden aus der Vergangenheit vor allem das Ich der Erzähler/-innen, deren eigene Gefühle und Selbstvergewisserung in einer von Unsicherheiten geprägten Gegenwart.

  15. [Ressenya del llibre Landscape indicators: Assessing and monitoring landscape quality, de Claudia Cassatella, Attilia Peano (eds.)

    OpenAIRE

    Llausàs i Pascual, Albert

    2012-01-01

    Ressenya de 'Landscape indicators: assessing and monitoring landscape quality', un llibre que fa un repàs de l'estat de la qüestió dels indicadors del paisatge i formula propostes a partir d’experiències d’aplicació a la regió italiana del Piemonte

  16. Andrea Fleschenberg, Claudia Derichs: Handbuch Spitzenpolitikerinnen. Wiesbaden: VS Verlag für Sozialwissenschaften 2008

    Directory of Open Access Journals (Sweden)

    Christiane Lemke

    2009-07-01

    Full Text Available „Frauen an die Macht“ – diese schon vor Jahrzehnten erhobene Forderung ist heute immer noch aktuell. Die politische Partizipation von Frauen hat sich zwar deutlich verbessert, aber in Führungspositionen sind sie immer noch selten anzutreffen. Das anschauliche Handbuch führt für alle Erdteile detailliert aus, unter welchen sozioökonomischen, institutionellen und kulturellen Einflussfaktoren Frauen zu Staats- und/oder Regierungschefinnen werden. Zahlreiche Einzelbiographien beleuchten die persönlichen Hintergründe.“Women in positions of power” – This centuries-old demand is still pertinent today. Women’s participation in politics has admittedly gotten much better, but they are still rarely seen in positions of leadership. The descriptive handbook provides details for each continent, illustrating under which socioeconomic, institutional, and cultural influential factors women become heads of state or government. Numerous individual biographies illuminate the personal histories.

  17. Porträtmedaillons aus Wachs Claudias de’ Medici und Federicos Ubaldo della Rovere

    Czech Academy of Sciences Publication Activity Database

    Vácha, Štěpán

    -, č. 9 (2009), s. 133-137 ISSN 1213-5372 Institutional research plan: CEZ:AV0Z80330511 Keywords : wax plastic * wax portrait medallion * artistic craft Subject RIV: AL - Art, Architecture, Cultural Heritage

  18. Informe científico de investigador: Natalucci, Claudia Luisa (2011-2012)

    OpenAIRE

    Natalucci, Claudia Luisa

    2012-01-01

    Durante el presente período he dado continuidad al proyecto de investigación vinculado a la aplicación de endopeptidasas y de sus inhibidores así como de péptidos obtenidos por hidrólisis con dichas proteasas. El mencionado proyecto de investigación tiene como objetivo implementar -con la participación de otros grupos de investigación del país y del exterior- el estudio de las posibles aplicaciones industriales y farmacológicas de las fitoproteasas purificadas en el LIProVe, de sus inhibidore...

  19. Alimentación del adulto mayor según lugar de residencia Claudia

    OpenAIRE

    Troncoso Pantoja, Claudia; Universidad Católica de la Santísima Concepción. Chile.

    2017-01-01

    El crecimiento exponencial en los últimos tiempos de la población adulta mayor hace necesario el profundizar en la alimentación y las conductas alimentarias que presentan estas personas, como una forma de mejorar su calidad de vida y salud, en el que influye, entre otros factores, el lugar donde habitan. Este artículo profundiza en la alimentación que presentan los adultos mayores, según su lugar de residencia: centros de larga estadía u otro tipo de domicilio. El comportamiento alimentario d...

  20. Review: Claudia Bruns & Tilmann Walter (Hsg.) (2004). Von Lust und Schmerz. Eine Historische Anthropologie der Sexualität

    OpenAIRE

    Barth, Volker

    2005-01-01

    Der Sammelband enthält elf Aufsätze, die sich um die Darstellung sozialer Praktiken von Sexualität bemühen. Sexualität wird aus einer spezifisch historisch-anthropologischen Sichtweise als etwas Gelebtes, als menschliche Alltagserfahrung aufgefasst. Der Schwerpunkt liegt im 19. Jahrhundert, wobei sich drei Artikel der Sexualität in der Frühen Neuzeit widmen. Anhand von Beispielen wie Hysterie, Homosexualität, Rassenhygiene, Familienplanung, jüdische Sexualität und Verjüngungskuren werden Selb...

  1. Claudia Vorheyer: Prostitution und Menschenhandel als Verwaltungsproblem. Eine qualitative Untersuchung über den beruflichen Habitus. Bielefeld: transcript Verlag 2010.

    Directory of Open Access Journals (Sweden)

    Eva Buchholz

    2012-02-01

    Full Text Available Die wissenssoziologische Arbeit untersucht die beruflichen Habitusformationen von sozialen Akteur/-innen in deutschen, polnischen und tschechischen Kommunen, die in ihrem beruflichen Alltag an der Regulierung von Prostitution beteiligt sind und/oder sich der Bekämpfung und Prävention von Menschenhandel zum Zweck der sexuellen Ausbeutung bzw. der Betreuung von Betroffenen widmen. Anhand 45 Expert/-inneninterviews wurden die Wahrnehmungs-, Denk- und Handlungsmuster von Verwaltungsakteur/-innen aus Polizeibehörden, Ordnungs- und Gesundheitsämtern sowie von Praktiker/-innen aus der Sozialen Arbeit rekonstruiert. Die Untersuchung liefert wertvolle Einblicke in die Verwaltungspraxis und in die sie konstituierenden Faktoren, die in der Analyse von Prostitutionspolitiken sonst häufig unbeachtet bleiben.This study, located in the field of sociology of knowledge, analyzes the professional habitus formations of social workers in German, Polish, and Czech municipalities, who are concerned with the regulation of prostitution in their daily work routine and/or who are dedicated to fighting and preventing human trafficking for the purpose of sexual exploitation or to the care of victims. Based on forty-five expert interviews, the perceptual, thought, and action patterns of administrative agents in police departments, regulatory authorities, and health authorities as well as of social work practitioners are reconstructed. The study offers valuable insights into the administrative practice and its constituting factors that otherwise frequently remain unnoticed in the analysis of prostitution politics.

  2. Die Reichweite der Haftungsprivilegien nach dem SGB VII außerhalb des klassischen Arbeitsunfalls / Tobias Matz ; Claudia Baumann

    Index Scriptorium Estoniae

    Matz, Tobias

    2016-01-01

    Ettevõtte ja kollektiivi vastutusest sotsiaalseadustiku § 104 jj tähenduses ebatraditsiooniliste tööõnnetuste korral (nt koolides õpilaste/õpetajate vigastused; praktikandid kutseõppes; loomade tekitatud vigastused jms)

  3. Review: Ingrid Miethe, Claudia Kajatin & Jana Pohl (Eds. (2004. Geschlechterkonstruktionen in Ost und West. Biografische Perspektiven [Gender Constructions in East and West. Biographical Perspectives

    Directory of Open Access Journals (Sweden)

    Nicola Döring

    2006-03-01

    Full Text Available This reader contains analyses of gender constructions in East and West Germany from biographical perspectives. It is based on narrative interviews with women and men living in the former East and West. By means of case reconstructions and case comparisons the authors reveal how individuals deal actively with specific societal gender roles. Historical differences between women's movement and feminism in East Germany versus West Germany are knowledgeably described. The book offers a very complex and multilayered theoretical and empirical construction of gender in its diverse dimensions, but men's biographies and men's studies remain marginalized. Men's movements as well as the gay rights movement are blind spots. The gendering of work and the context of European unification are emphasized. URN: urn:nbn:de:0114-fqs0602353

  4. Claudia Soria, Paola Cortés Rocca & Edgardo Dieleke (Eds.), Políticas del sentimiento. El peronismo y la construcción de la Argentina Moderna, Buenos Aires, Editorial Prometeo, 2010, 287 p.

    OpenAIRE

    Cristiá, Moira

    2011-01-01

    La recurrente e incansable pregunta por la esencia del peronismo se plasma en este libro en una pléyade de reflexiones sobre productos artísticos, sociales y culturales que se desarrollaron desde los años cuarenta alrededor del mismo. Encontramos allí interpretaciones,  explicaciones, cuestionamientos e inspiraciones en torno a este fenómeno típicamente argentino. A partir de esa gesta romántica en la que las masas inundaron como marea el centro de la ciudad capital y sus puntos más simbólico...

  5. Antineoplastic-related cardiotoxicity, morphofunctional aspects in a murine model: contribution of the new tool 2D-speckle tracking

    Directory of Open Access Journals (Sweden)

    Coppola C

    2016-11-01

    Full Text Available Carmela Coppola,1 Gennaro Riccio,1 Antonio Barbieri,2 Maria Gaia Monti,3 Giovanna Piscopo,1 Domenica Rea,2 Claudio Arra,2 Carlo Maurea,1 Claudia De Lorenzo,4,5 Nicola Maurea1 1Division of Cardiology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 2Animal Facility Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 3Department of Translational Medical Sciences, University Federico II, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology, University Federico II, Naples, Italy; 5CEINGE Biotecnologie Avanzate, Naples, Italy Objective: Considering that global left ventricular systolic radial strain is a sensitive technique for the early detection of left ventricular dysfunction due to antineoplastics and the analysis of segmental myocardial contractility, we evaluated this technique for early detection of trastuzumab-related cardiotoxicity by comparing it with cardiac structural damage.Methods: Groups of six mice were injected with trastuzumab or doxorubicin, used either as single agents or in combination. Cardiac function was evaluated by transthoracic echocardiography measurements before and after treatment for 2 or 7 days, by using a Vevo 2100 high-resolution imaging system. After echocardiography, mice were euthanized, and hearts were processed for histological evaluations, such as cardiac fibrosis, apoptosis, capillary density, and inflammatory response.Results: Trastuzumab-related cardiotoxicity was detected early by 2D strain imaging. Radial strain was reduced after 2 days in mice treated with trastuzumab alone (21.2%±8.0% vs 40.5%±4.8% sham; P<0.01. Similarly, trastuzumab was found to induce apoptosis, capillary density reduction, and inflammatory response in cardiac tissue after 2 days of treatment, in a fashion similar to doxorubicin. On the contrary, fractional

  6. Indian Academy of Sciences Conference Series | Indian Academy of ...

    Indian Academy of Sciences (India)

    RQA correlations on real business cycles time series. GIUSEPPE ORLANDO GIOVANNA ... Determinism; numerical chaos; applications to economics; economic dynamics. Abstract. Trade cycles are complex phenomena which oscillate because of economic downturns and expansions. Recurrence quantification analysis ...

  7. Fulltext PDF

    Indian Academy of Sciences (India)

    Unknown

    Daniel R Brooks, Toronto. Masha Brown, Toronto. Terry Brown, Manchester. Janusz M Bujnicki, Warsaw. Giovanna Caderni, Firenze. Chris Carlton, Baton Rouge. Dipankar Chatterji, Bangalore. Joydev Chattopadhyay, Kolkata. Amit Chattopadhyay, Hyderabad. Arabinda Chaudhuri, Hyderabad. Michael Cherry, Matieland.

  8. Carbon stocks in a 50-year-old Eucalyptus camaldulensis stand in ...

    African Journals Online (AJOL)

    Carbon stocks in a 50-year-old Eucalyptus camaldulensis stand in Sicily, Italy. Riccardo Scalenghe, Luisella Celi, Giovanna Costa, V Armando Laudicina, Stefania Santoni, Dario Vespertino, Tommaso La Mantia ...

  9. “They All Lived Happily Ever After. Obviously” : Realism and Utopia in Game of Thrones-Based Alternate Universe Fairy Tale Fan Fiction, Special Issue “Fairy Tale and its Uses in Contemporary New Media and Popular Culture,” Ed Claudia Schwabe

    NARCIS (Netherlands)

    Kustritz, A.M.

    2016-01-01

    Fan fiction alternate universe stories (AUs) that combine Game of Thrones characters and settings with fairy tale elements construct a dialogue between realism and wonder. Realism performs a number of functions in various genres, but becomes a particularly tricky concept to tie down in fantasy.

  10. Introduction: Information and Musings

    Science.gov (United States)

    Shifman, M.

    The following sections are included: * Victor Frenkel * Background * The Accused * Alexander Leipunsky * Alexander Weissberg * Holodomor * The beginning of the Great Purge * Other foreigners at UPTI * The Ruhemanns * Tisza * Lange * Weisselberg * A detective story * Stalin's order * Yuri Raniuk * Giovanna Fjelstad * Giovanna's story * First time in the USSR * Fisl's humor * Houtermans and Pomeranchuk * Choices to make * Closing gaps * Houtermans and the Communist Party of Germany * Houtermans and von Ardenne * Houtermans' trip to Russia in 1941 * Why Houtermans had to flee from Berlin in 1945 * Houtermans in Göttingen in the 1940's * Denazification * Moving to Bern * Yuri Golfand, the discoverer of supersymmetry * Bolotovsky's and Eskin's essays * Moisei Koretz * FIAN * Additional recommended literature * References

  11. Tematiche, generi, ideologie nella costruzione cinematografica del mito johannique

    OpenAIRE

    Nastri, Manuela

    2011-01-01

    Con il termine francese “johannique”, ci si riferisce di solito agli studi su Giovanna d’Arco. Infatti, La Pulzella d’Orléans è un soggetto ideale per molte aree scientifiche (storia, psicologia, studi di genere…). Allo stesso modo, anche arte e letteratura prendono spesso ispirazione dalla sua leggenda. Così, attraverso i secoli, il suo ruolo è stato sempre oggetto di dibattito ideologico. Giovanna è una Santa per la Chiesa Cattolica, un simbolo nazionalista per gli estremisti di destra, una...

  12. Masculinidades subversivas nos romances de Manuel Puig, Caio Fernando Abreu e Jaime Bayly

    Directory of Open Access Journals (Sweden)

    Oswaldo Alves Lara Neto

    2014-05-01

    Full Text Available Produção: Claudia Priscilla e Pedro Marques. Vestido de Laerte. São Paulo: Paleo TV, 2012. 1 HDCAM.   Produção: Claudia Priscilla e Kiko Goifman. Olhe para mim de novo. São Paulo: Paleo TV, 2011. 1 HDCAM

  13. On Framing

    DEFF Research Database (Denmark)

    Peder Pedersen, Claus

    2018-01-01

    On framing as artistic and conceptual tool in the works of Claudia Carbone. Contribution to exhibition at the Aarhus School of Architecture.......On framing as artistic and conceptual tool in the works of Claudia Carbone. Contribution to exhibition at the Aarhus School of Architecture....

  14. Browse Title Index - African Journals Online

    African Journals Online (AJOL)

    Jefferson Rocha A. Silva, Claudia M. Rezende, Angelo C. Pinto, Ana Claudia F. Amaral. Vol 6, No 11 (2007), Cytotoxicity and antimicrobial studies of 1,6,8- trihydroxy-3-methyl-anthraquinone (emodin) isolated from the leaves of Cassia nigricans Vahl, Abstract PDF. RG Ayo, JO Amupitan, Y Zhao. Vol 9, No 5 (2010) ...

  15. Veneetsia filmifestival ilmutas auhindu jagades tolerantsi / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2005-01-01

    62. Veneetsia filmifestivali auhinnasaajad. Parima filmi Kuldlõvi sai Ang Lee "Brokebacki mägi", žürii eripreemia Abel Ferrara (artiklis "Ferrera") "Mary", parimaks naisnäitlejaks tituleeriti Giovanna Mezzogiorno, Marcello Mastroianni nimelise noore näitleja preemia sai Menothy Cesar

  16. Understanding Girls' Circle as an Intervention on Perceived Social Support, Body Image, Self-Efficacy, Locus of Control, and Self-Esteem

    Science.gov (United States)

    Steese, Stephanie; Dollette, Maya; Phillips, William; Hossfeld, Elizabeth; Matthews, Gail; Taormina, Giovanna

    2006-01-01

    The Girls' Circle is a support group for adolescent girls developed by Beth Hossfeld and Giovanna Taormina as a unique program that addresses the needs of girls by focusing on increasing connections, building empathic skills, and developing resiliency. The present study evaluates the effectiveness of the Girls' Circle intervention on improving…

  17. Indian Academy of Sciences Conference Series | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Indian Academy of Sciences Conference Series. GIOVANNA ZIMATORE. Articles written in Indian Academy of Sciences Conference Series. Volume 1 Issue 1 December 2017 pp 35-41 Proceedings of the Conference on Perspectives in Nonlinear Dynamics - 2016. RQA correlations on real business cycles ...

  18. Utilizing an Energy Management System with Distributed Resources to Manage Critical Loads and Reduce Energy Costs

    Science.gov (United States)

    2014-09-01

    refers both to nonrenewable generation systems such as microturbines, gas turbines, internal combustion generators and renewable generation systems...natural gas, methanol , propane, and gasoline [13]. Although fuel cells are generally categorized as a generation system and not a storage device...ELECTRICAL ENGINEERING from the NAVAL POSTGRADUATE SCHOOL September 2014 Author: David J. Gustafson Approved by: Giovanna Oriti

  19. Integration and Control of a Battery Balancing System

    Science.gov (United States)

    2013-12-01

    battery charger topologies, charging power levels, and infrastructure for plug-in electric and hybrid vehicles ,” in IEEE Trans. Edu., vol. 28, no. 5...MASTER OF SCIENCE IN ELECTRICAL ENGINEERING from the NAVAL POSTGRADUATE SCHOOL December 2013 Author: Peter L. Norgaard...Approved by: Alexander L. Julian Thesis Advisor Giovanna Oriti Second Reader R. Clark Robertson Chairman, Department of Electrical

  20. Author Details

    African Journals Online (AJOL)

    Sansalvadore, Giovanna. Vol 29, No 1 (2016) - Articles The zombie and his italian half brother: the satiric use of the zombie myth in the short story Zoologo by Niccolò Ammaniti Abstract. ISSN: 2225-7039. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  1. Indian Academy of Sciences Conference Series | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Indian Academy of Sciences Conference Series; Volume 1; Issue 1. RQA correlations on real business cycles time series. GIUSEPPE ORLANDO GIOVANNA ZIMATORE. Proceedings of the Conference on Perspectives in Nonlinear Dynamics - 2016 Volume 1 Issue 1 December 2017 pp 35-41 ...

  2. Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial.

    Science.gov (United States)

    Alvarez, Ofelia; Yovetich, Nancy A; Scott, J Paul; Owen, William; Miller, Scott T; Schultz, William; Lockhart, Alexandre; Aygun, Banu; Flanagan, Jonathan; Bonner, Melanie; Mueller, Brigitta U; Ware, Russell E

    2013-11-01

    To compare the non-neurological events in children with sickle cell anemia (SCA) and previous stroke enrolled in SWiTCH. The NHLBI-sponsored Phase III multicenter randomized clinical trial stroke with transfusions changing to hydroxyurea (SWiTCH) (ClinicalTrials.gov NCT00122980) compared continuation of chronic blood transfusion/iron chelation to switching to hydroxyurea/phlebotomy for secondary stroke prevention and management of iron overload. All randomized children were included in the analysis (intention to treat). The Fisher's Exact test was used to compare the frequency of subjects who experienced at least one SCA-related adverse event (AE) or serious adverse event (SAE) in each arm and to compare event rates. One hundred and thirty three subjects, mean age 13 ± 3.9 years (range 5.2-19.0 years) and mean time of 7 years on chronic transfusion at study entry, were randomized and treated. Numbers of subjects experiencing non-neurological AEs were similar in the two treatment arms, including SCA-related events, SCA pain events, and low rates of acute chest syndrome and infection. However, fewer children continuing transfusion/chelation experienced SAEs (P = 0.012), SCA-related SAEs (P = 0.003), and SCA pain SAEs (P = 0.016) as compared to children on the hydroxyurea/phlebotomy arm. The timing of phlebotomy did not influence SAEs. Older age at baseline predicted having at least 1 SCA pain event. Patients with recurrent neurological events during SWiTCH were not more likely to experience pain. In children with SCA and prior stroke, monthly transfusions and daily iron chelation provided superior protection against acute vaso-occlusive pain SAEs when compared to hydroxyurea and monthly phlebotomy. Copyright © 2013 Wiley Periodicals, Inc.

  3. Tants ei küsi vanust / Ille Grün-Ots, Siiri Rebane

    Index Scriptorium Estoniae

    Grün-Ots, Ille, 1960-2016

    2007-01-01

    Kanal 2 menusaate "Tantsud tähtedega" järellainetuses vesteldakse artiklis seltskonnatantsust Revalia tantsukooli juhataja Merle Klandorfiga, bailatinost Dance Act direktori Georg Kodusaarega, kõhutantsust tantsuõpetaja Diana Otsinguga ja flamenkost Claudia Shevsthenkoga

  4. Zur historischen Aufarbeitung und medialen Vermittlung der Shoah in Italien und Deutschland

    Directory of Open Access Journals (Sweden)

    Peter Kuon

    2016-03-01

    Full Text Available Claudia Müller, Patrick Ostermann und Karl-Siegbert Rehberg, Hrsg., Die Shoah in Geschichte und Erinnerung: Perspektiven medialer Vermittlung in Italien und Deutschland (Bielefeld: transcript, 2015.

  5. Eesti turvafirmade vappe

    Index Scriptorium Estoniae

    1998-01-01

    Firmad: AS ESS, Viking Valve, Barracuda Turvakaitse AS, Barbaros, Akropol A AS, AS Claudia Turvasüsteemid, ESSEC Security, AS Tammiskilp, Eesti Turvateenistuse AS (ESC), Scorpioni Julgestusteenistuse AS

  6. The CMS Collaboration Board (CB) chairperson, deputy and secretary, with the CMS Spokesperson and deputies

    CERN Multimedia

    Lapka, M

    2012-01-01

    From left to right: Jorgen D'Hondt (CB Secretary), Claudia Wulz (CB Deputy Chair), Tiziano Camporesi (Deputy Spokesperson), Ian Shipsey (new CB Chair 2013-2014), Joe Incandela (CMS Spokesperson), Joao Varela (Deputy Spokesperson)

  7. Ladina-Ameerika filme saadab edu / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2009-01-01

    Berliini 59. rahvusvahelise filmifestivali peaauhinna Kuldkaru saanud peruulanna Claudia Llosa mängufilmist "Kurbuse piim" ("La teta asustada"). Põgusalt ka Mehhiko rahvusvahelisest filmifestivalist FICCO ja juudi filmide festivalist Uruguais

  8. Modelliagentuurid toodavad Carmen Kassile tasemel järglasi / Kerli Nõu

    Index Scriptorium Estoniae

    Nõu, Kerli

    2006-01-01

    Eestis tegutsevatest modelliagentuuridest Beatrice Mass Modelnet, Baltic Models OÜ ja Eesti Modelliagentuuri OÜ. Kommentaarid: Tasane algus kulisside taga, Edukad Eesti modellid (Annika Vohta), Eesti uus Carmen Kass (Claudia Meriküla)

  9. 78 FR 76160 - Public Housing Assessment System (PHAS) Capital Fund Interim Scoring Notice: Reinstitution of...

    Science.gov (United States)

    2013-12-16

    ... www.regulations.gov . FOR FURTHER INFORMATION CONTACT: Claudia J. Yarus, Real Estate Assessment Center... comment on this interim notice, and will consider all significant and relevant issues raised in issuing a...

  10. In vivo NMR study of yeast fermentative metabolism in the presence ...

    Indian Academy of Sciences (India)

    2011-03-14

    . MASO RICCI. 1,2,*, SILVIA MARTINI. 1,2. , CLAUDIA BONECHI. 1,2. , DANIELA BRACONI. 3. , ANNALISA SANTUCCI. 3 and CLAUDIO ROSSI. 1,2. 1Department of Pharmaceutical and Applied Chemistry, University of Siena ...

  11. Storia, precariato e criminalità. La narrativa italiana racconta la politica contemporanea

    Directory of Open Access Journals (Sweden)

    Paolo Chirumbolo

    2015-07-01

    Full Text Available Recensione di: Claudia Boscolo e Stefano Jossa (a cura di, Scritture di resistenza. Sguardi politici dalla narrativa italiana contemporanea, Roma, Carocci Editore, 2014, 204 p. ISBN: 9788843074143, € 16,00.

  12. Linna luksuslik liider / Lea Veelma

    Index Scriptorium Estoniae

    Veelma, Lea, 1947-2007

    2006-01-01

    Tallinna vanalinnas asuv Schlössle Hotell arvati ametlikult ülemaailmse luksushotellide keti The Leading Hotels of the World (LHW) liikmeks. Sündmuse puhul viibis Tallinnas LHW asepresident Claudia Roth

  13. Life's crucible.

    Science.gov (United States)

    Radetsky, P

    1998-02-01

    Research by German chemists Gunter Wachtershauser and Claudia Huber about the origins of life is reviewed. Other theories about the beginning of life on Earth are examined with comments by noted researchers.

  14. Kunstnikud käivad katuseid mööda / Hanno Soans

    Index Scriptorium Estoniae

    Soans, Hanno, 1974-

    2010-01-01

    Näitus "Linna kohal" Tallinna Linnagaleriis 19. septembrini 2010. Osalevad Anu Vahtra, Johnson & Johnson, Timo Toots, Claudia Doms, Mikk Heinsoo, Urmo Mets, Marit Ilison. Kuraatorid Kadri Klementi ja Helis Teiter. Näituse teemaks on linnamajade kasutamata katusepinnad

  15. Modern Milano. A survey about transformation of architectural and urban heritage

    Directory of Open Access Journals (Sweden)

    Giovanna D’Amia

    2009-12-01

    Full Text Available The XX Century Milan estate of buildings records the renovation of the culture and the predominance of the Rationalism between the World Wars and the Second postwar. Nevertheless, it is still unknown and poorly documented and it has often suffered radical transformations. Giovanna D’Amia and Luca Tamini formulated an hypothesis of an observatory of the Modern Milan as an interdisciplinary research to deeply know and valorise this estate of buildings, to survey their conditions and to propose guidelines for future interventions. An archive of data and graphic documents of 45 selected buildings has been created by Giovanna D’Amia Course of Contemporary History of Architecture (year 2008/2009 in order to verify the fairness of this approach. Nowadays it is possible to drew up a first balance of the research.

  16. Reducing Electromagnetic Interference in a Grid Tied Single Phase Power Inverter

    Science.gov (United States)

    2016-09-01

    ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER INVERTER by Jason Hassan Valiani September 2016 Thesis Advisor: Giovanna Oriti...3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE REDUCING ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER...The addition of a passive filter proved to minimize the conducted EMI for a single -phase grid-tied inverter. 14. SUBJECT TERMS single -phase

  17. Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia.

    Science.gov (United States)

    Opoka, Robert O; Ndugwa, Christopher M; Latham, Teresa S; Lane, Adam; Hume, Heather A; Kasirye, Phillip; Hodges, James S; Ware, Russell E; John, Chandy C

    2017-12-14

    Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown. In vitro studies suggest hydroxyurea could increase malaria severity, and hydroxyurea-associated neutropenia could worsen infections. NOHARM (Novel use Of Hydroxyurea in an African Region with Malaria) was a randomized, double-blinded, placebo-controlled trial conducted in malaria-endemic Uganda, comparing hydroxyurea to placebo at 20 ± 2.5 mg/kg per day for 12 months. The primary outcome was incidence of clinical malaria. Secondary outcomes included SCA-related adverse events (AEs), clinical and laboratory effects, and hematological toxicities. Children received either hydroxyurea (N = 104) or placebo (N = 103). Malaria incidence did not differ between children on hydroxyurea (0.05 episodes per child per year; 95% confidence interval [0.02, 0.13]) vs placebo (0.07 episodes per child per year [0.03, 0.16]); the hydroxyurea/placebo malaria incidence rate ratio was 0.7 ([0.2, 2.7]; P = .61). Time to infection also did not differ significantly between treatment arms. A composite SCA-related clinical outcome (vaso-occlusive painful crisis, dactylitis, acute chest syndrome, splenic sequestration, or blood transfusion) was less frequent with hydroxyurea (45%) than placebo (69%; P = .001). Children receiving hydroxyurea had significantly increased hemoglobin concentration and fetal hemoglobin, with decreased leukocytes and reticulocytes. Serious AEs, sepsis episodes, and dose-limiting toxicities were similar between treatment arms. Three deaths occurred (2 hydroxyurea, 1 placebo, and none from malaria). Hydroxyurea treatment appears safe for children with SCA living in malaria-endemic sub-Saharan Africa, without increased severe malaria, infections, or AEs. Hydroxyurea provides SCA-related laboratory and clinical

  18. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... el Comportamiento, Parte 1 CareMAP: Medicamentos y la Salud en General, Parte 1 Expert Briefings: Apathy or ... Disease? Hallucinations and Delusions CareMAP: Medicamentos y la Salud en General, Parte 2 Dra. Claudia Martinez, MAPC - ...

  19. Globally threatened biodiversity of the Eastern Arc Mountains and ...

    African Journals Online (AJOL)

    Globally threatened biodiversity of the Eastern Arc Mountains and Coastal Forests of Kenya and Tanzania. Roy E. Gereau, Neil Cumberlidge, Claudia Hemp, Axel Hochkirch, Trevor Jones, Mercy Kariuki, Charles N. Lange, Simon P. Loader, Patrick K. Malonza, Michele Menegon, P. Kariuki Ndang'ang'a, Francesco Rovero, ...

  20. Autonomous Military Robotics: Risk, Ethics, and Design

    Science.gov (United States)

    2008-12-20

    Engineering the Total Ship (ETS) Symposium, September 23-25. 2008, Falls Church, VA. Čapek , Karel (1921). R.U.R. (2004 edition, trans. Claudia...the popular play R.U.R. (or Rossum’s Universal Robots) by Czech author Karel Čapek . The dystopian play featured factory-built, artificial people

  1. Response to June Boyce-Tillman, "Towards an Ecology of Music Education"

    Science.gov (United States)

    Gluschankof, Claudia

    2004-01-01

    Claudia Gluschankof begins this article with two confessions. First, music was not her favorite class at school. She cannot even recall what was done there. It did not at all connect with the powerful, meaningful place that music had in her private life, where she loved to sing with family, and play and sing in ensembles in classes at a private…

  2. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... el Comportamiento, Parte 1 CareMAP: Medicamentos y la Salud en General, Parte 1 Expert Briefings: Apathy or ... CareMAP: Caring from Afar CareMAP: Medicamentos y la Salud en General, Parte 2 Dra. Claudia Martinez, MAPC - ...

  3. Por lo menos quedó la historia

    Directory of Open Access Journals (Sweden)

    Jimena Montaña Cuéllar

    2007-10-01

    Full Text Available Historia del Hospital San Juan de Dios de Bogotá. María Claudia Romero lsaza, Mónica Zambrano Caicedo, Miguel Darío Cárdenas. Alcaldía Mayor de Bogotá, Instituto de Patrimonio Cultural, Universidad Nacional de Colombia, Bogotá, 2008, 149 págs.

  4. An Update to the Budget and Economic Outlook: 2014 to 2024

    Science.gov (United States)

    2014-08-01

    Davis, Roger W. Ferguson, Jr., Claudia Goldin, Robert E. Hall, Jan Hatzius, Simon Johnson , Anil Kashyap, Lawrence Katz, Donald Kohn, N. Gregory Mankiw...occupational illness, other programs) Dwayne Wright Veterans’ compensation and pensions Health Kirstin Blom Medicaid, Children’s Health Insurance Program

  5. 78 FR 21603 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2013-04-11

    ...; Inversiones Plano, LP, Claudia Esteve Vila, and Maria Esteve Vila, all of Dallas, Texas: Double B. Holdings..., and Carlos Francisco Prieto Sierro, all of Mexico City, Mexico; Mata Martin, S.A.P.I. de C.V. and... Reserve Bank of St. Louis (Yvonne Sparks, Community Development Officer) P.O. Box 442, St. Louis, Missouri...

  6. African Journal of Health Professions Education: Contact

    African Journals Online (AJOL)

    Principal Contact. Claudia Naidu Managing Editor Health and Medical Publishing Group Private Bag X1 Pinelands 7430 Cape Town South Africa Phone: + 27 (21) 532 1281. Email: claudian@hmpg.co.za. Support Contact. Getrude Fani Phone: +27 (21) 532 1281. Email: publishing@hmpg.co.za · AJOL African Journals ...

  7. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... el Comportamiento, Parte 1 CareMAP: Medicamentos y la Salud en General, Parte 1 Expert Briefings: Apathy or ... and Rewards of Caregiving CareMAP: Medicamentos y la Salud en General, Parte 2 Dra. Claudia Martinez, MAPC - ...

  8. African Journal of Biotechnology - Vol 15, No 25 (2016)

    African Journals Online (AJOL)

    Micropropagation of Handroanthus heptaphyllus (Vell.) Mattos from seedling explants · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Evelyn Duarte, Pedro Sansberro, Claudia Luna, 1292-1298. http://dx.doi.org/10.5897/AJB2015.15194 ...

  9. Micropropagation of Handroanthus heptaphyllus (Vell.) Mattos from ...

    African Journals Online (AJOL)

    Micropropagation of Handroanthus heptaphyllus (Vell.) Mattos from seedling explants. Evelyn Duarte, Pedro Sansberro, Claudia Luna. Abstract. Handroanthus heptaphyllus (Vell.) Mattos (Bignoniaceae), a tropical forest tree, is a source of wood suitable for the manufacture of fine furniture and chemical compounds with ...

  10. On Consumerism, Collective Action, and Whether Art Teaches Anything

    Science.gov (United States)

    Ruitenberg, Claudia W.

    2014-01-01

    In this review essay, Claudia Ruitenberg discusses Trevor Norris's "Consuming Schools," René Arcilla's "Mediumism," and Martha Nussbaum's "Not for Profit." While the primary focus of each book is different--with Norris concentrating on the pressures of consumerism and commercialism on K-12 schooling,…

  11. Journal of East African Natural History - Vol 105, No 1 (2016)

    African Journals Online (AJOL)

    ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Roy E. Gereau, Neil Cumberlidge, Claudia Hemp, Axel Hochkirch, Trevor Jones, Mercy Kariuki, Charles N. Lange, Simon P. Loader, Patrick K. Malonza, Michele Menegon, P. Kariuki Ndang'ang'a, Francesco Rovero, ...

  12. Installation Service - Changes in opening hours

    CERN Multimedia

    GS Department

    2010-01-01

    For organizational matters, please note that, as from 15 March 2010, the Installation Service will have wen opening hours. The new schedule will be from 14:00 to 17:00 (Monday to Friday). Contact persons are: Martine Briant, Karine Robert and Claudia Bruggmann. The office address remains 73-3-014. Installation Service

  13. Alkaline pretreatment of Mexican pine residues for bioethanol ...

    African Journals Online (AJOL)

    Alkaline pretreatment of Mexican pine residues for bioethanol production. Claudia Elena Soto Alvarez, Javier López Miranda, Gustavo Pérez Verdín, Mario A. Rodríguez Pérez, Isaías Chairez Hernández ...

  14. Sexual and reproductive health risk behaviours among South ...

    African Journals Online (AJOL)

    Sexual and reproductive health risk behaviours among South African university students: results from a representative campus-wide survey. Susie Hoffman, Michael Levasseur, Joanne E. Mantell, Mags Beksinska, Zonke Mabude, Claudia Ngoloyi, Elizabeth A. Kelvin, Theresa Exner, Cheng-Shiun Leu, Lavanya Pillay, ...

  15. INTRODUCTION/ BACKGROUND OF STUDY

    African Journals Online (AJOL)

    user

    processed, can provide balanced diet protecting millions of African children against malnutrition. Cassava is the most important root crop grown in Nigeria. Its potentials in the fight against hunger and food insecurity is documented (Gregory J. Scott, Mark. W. Rose grant and Claudia Kingler (2000). Cassava ranks among the ...

  16. Reseñas

    Directory of Open Access Journals (Sweden)

    Claudia Nora Laudano

    2013-04-01

    Full Text Available Tecnología y cambio social: El impacto del acceso público a las computadoras e internet en Argentina, Chile y Perú de Francisco J. Proenza (ed. por Claudia N. LaudanoEl dédalo y su ovillo: ensayos sobre la palpitante cultura impresa en la Argentina de Alejandro E. Parada por Marcela Coria

  17. 75 FR 42981 - Concept Release on the U.S. Proxy System

    Science.gov (United States)

    2010-07-22

    ... of Trading & Markets, at (202) 551- 5777, Holly L. Hunter-Ceci or Brian P. Murphy, Division of... developments, such as the revisions to Rule 452 of the New York Stock Exchange (``NYSE'') limiting the ability... tender their resignation to the board, which resignation the board may or may not accept. See Claudia H...

  18. 21. sajandi organisatsioon / Vello Rääk

    Index Scriptorium Estoniae

    Rääk, Vello

    2006-01-01

    Mõtteid McKinsey konsultantide Lowell L. Bryan ja Claudia Joyce väljaandes McKinsey Quarterly, 2005, nr. 3 ilmunud artiklist "The 21st Century Organization", mis käsitleb teadmustöötajate produktiivsuse olukorda ning selle tõstmist

  19. CCR researchers show that blocking the estrogen receptor restores the sensitivity of lung cancer cells to therapy | Center for Cancer Research

    Science.gov (United States)

    Claudia Palena, Ph.D., of CCR’s Laboratory of Tumor Immunology and Biology, and her colleagues wondered if it would be possible to identify compounds that could reverse the therapy resistance imparted by the process called epithelial-mesenchymal transition (EMT) in lung cancer.

  20. Metabolic response to exogenous ethanol in yeast: An in vivo ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 37; Issue 4. Metabolic response to exogenous ethanol in yeast: An in vivo statistical total correlation NMR spectroscopy approach. Maso Ricci Marianna Aggravi Claudia Bonechi Silvia Martini Anna Maria Claudio Rossi. Articles Volume 37 Issue 4 September 2012 pp 749- ...

  1. African Journal of Biotechnology - Vol 15, No 36 (2016)

    African Journals Online (AJOL)

    Optimization of somatic embryogenesis procedure for commercial clones of Theobroma cacao L. EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Claudia Garcia, Fabio Corrêa, Seth Findley, Alex-Alan Almeida, Marcio Costa, Juan Carlos Motamayor, Ray Schnell, ...

  2. How Brazil joined the quest for a yellow fever vaccine

    OpenAIRE

    2013-01-01

    Brazil recently announced an agreement between its Bio-Manguinhos vaccine unit and two US companies to research and develop a new yellow fever vaccine. Claudia Jurberg and Julia D’Aloisio talk to Jaime Benchimol about the controversial history of the development of the vaccine that benefits millions of people today.

  3. Scham im Kino : Kleine Phänomenologie eines peinlichen Gefühls

    NARCIS (Netherlands)

    Hanich, Julian

    Wer ans Kino denkt, denkt nicht an Scham. Die Emotionsmaschine „Kino“ rührt das Publikum zu Tränen, versetzt es in Angst und Schrecken oder zwingt es zum Lachen. Zuschauer reagieren wütend, erfreut, angeekelt, sie staunen und bewundern. Vielleicht sind sie sogar heimlich in Cary Grant oder Claudia

  4. Neue Generation, neue Medien und eine neue Bildung?

    NARCIS (Netherlands)

    Bastiaens, Theo; Schrader, Claudia

    2018-01-01

    Extract Neue Generation, neue Medien und eine neue Bildung? Theo Bastiaens & Claudia Schrader Abstract This chapter focuses on the question of what influence societal changes have on learners, their learning behavior and the curriculum. Fact is that there has been one major change with an

  5. The Political as Presence: On Agonism in Citizenship Education

    Science.gov (United States)

    Tryggvason, Ásgeir

    2017-01-01

    In recent years, an agonistic approach to citizenship education has been put forward as a way of educating democratic citizens. Claudia W. Ruitenberg (2009) has developed such an approach and takes her starting point in Chantal Mouffe's agonistic theory. Ruitenberg highlights how political emotions and political disputes can be seen as central for…

  6. Muslims ritualising death in the Netherlands: Death rites in a small town context

    NARCIS (Netherlands)

    Venhorst, C.J.H.

    2013-01-01

    Muslims ritualising death in the Netherlands. Death rites in a small town context. Claudia Venhorst This study on the common practice of Islamic death rites in the Netherlands affords valuable insights in the lived religion of Muslims. Particularly in a small town context, marked by migration and

  7. Traditsioonilise kujundkõne nüüdisaegsest uurimisest / Anneli Baran

    Index Scriptorium Estoniae

    Baran, Anneli, 1970-

    2015-01-01

    Tutvustus: Phraseologie und Parömiologie (sari ilmub aastast 1999; http://www.phraseologie.net ) ; Claudia Aurich. Proverb Structure in the History of English: Stability and Change. Schneider Verlag Hohengehren, 2012 ; Urška Valenčič Arh. "Ein Prinz auf der Erbse". Phraseologie und Übersetzung. Schneider Verlag GmbH, 2014

  8. Characterizing Treatable Causes of Small-Fiber Polyneuropathy in Gulf War Veterans

    Science.gov (United States)

    2017-10-01

    of these long axons easily malfunction and degenerate if their oxygen, nutrient, or energy supply is compromised, which results in small-fiber... Brazil ) Claudia Sommer, MD (University of Würzburg, Würzburg, Germany) Judith Spies, MBBS, FRACP, PhD (University of Sydney, Camperdown, Australia

  9. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... el Comportamiento, Parte 1 CareMAP: Medicamentos y la Salud en General, Parte 1 Expert Briefings: Apathy or ... Caregiving Hallucinations and Delusions CareMAP: Medicamentos y la Salud en General, Parte 2 Dra. Claudia Martinez, MAPC - ...

  10. a space of political engagement between realism and postmodernism

    African Journals Online (AJOL)

    User

    REALISM AND POSTMODERNISM. CLAUDIA BERNARDI. (Victoria University of Wellington). Sommario. L'opera di Silvia Ballestra è emblematica della transizione dei cosiddetti scrittori 'pulp' dalla produzione giovanile dei primi anni Novanta, di taglio esplicitamente sperimentale, ironico ed auto-riflessivo, a generi e stili ...

  11. 75 FR 65213 - Removal of Varietal Restrictions on Apples From Japan

    Science.gov (United States)

    2010-10-22

    .... Claudia Ferguson, M.S., Regulatory Policy Specialist, PPQ, APHIS, 4700 River Road, Unit 39, Riverdale, MD... stated that the varietal testing requirements constitute a trade barrier and suggested that, if Japan is... 1995 (44 U.S.C. 3501 et seq.). List of Subjects in 7 CFR Part 319 Coffee, Cotton, Fruits, Imports, Logs...

  12. Browse Title Index

    African Journals Online (AJOL)

    Items 101 - 150 of 250 ... Roy E. Gereau, Neil Cumberlidge, Claudia Hemp, Axel Hochkirch, Trevor Jones, Mercy Kariuki, Charles N. Lange, Simon P. Loader, Patrick K. Malonza, Michele Menegon, P. Kariuki Ndang'ang'a, Francesco Rovero, Philip Shirk. Vol 100, No 1&2 (2011), Globally threatened dragonflies (Odonata) in ...

  13. Художники ходят по крышам домов / Ханно Соанс

    Index Scriptorium Estoniae

    Соанс, Ханно, 1974-

    2010-01-01

    Näitusest "Linna kohal" Tallinna Linnagaleriis. Teemaks on linnamajade katusepindade kasutuselevõtt. Kuraatorid Kadri Klementi ja Helis Heiter. Töödest näitusel. Osalevad: Anu Vahtra — Tallinna Kunstihoone, Claudia Doms ja Mikk Heinsoo — Saku Suurhall, Timo Toots — Lennujaam, Marit Ilison — Telliskivi Loomelinnak, Johnson & Johnson — Postimaja

  14. Comentarios sobre las atribuciones a Sofonisba Anguissola por el Doctor Alfio Nicotra

    Directory of Open Access Journals (Sweden)

    Kusche, Maria

    2009-09-01

    Full Text Available At a meeting concerning Sofonisba Anguissola in Palermo (February 2008, the physician and art collector Dr. Alfio Nicotra (Catania, Sicily proposed several new attributions to the artist. Four of them are totally convincing and they are here integrated into Sofonisba’s oeuvre: La Madonna dell’ Itría, an image dedicated to the memory of Fabricio de Moncada, Anguissola’s husband; and portraits of Giovanna de Austria (daughter of Don Juan de Austria; Margarita de Saboya; and a Lateran Canon.

    El médico y coleccionista siciliano Dr. Alfio Nicotra, residente en Catania, Sicilia, presentó en un acto en honor a Sofonisba Anguissola, en Palermo en 2008, una serie de atribuciones a la pintora. Al parecerme acertadas las siguientes, aquí se intenta situarlas en su obra, que de este modo se ve considerablemente ampliada. Se trata de una imagen en memoria del marido de la pintora, Don Fabricio de Monacada, un retrato de Giovanna de Austria –hija de Don Juan de Austria–, uno de Margarita de Saboya y uno de un Canónigo Lateranense.

  15. Multinational Experiment 7. Outcome 3 - Cyber Domain, Objective 3.1: Threats and Vulnernability Methodology Version 1.0

    Science.gov (United States)

    2013-07-08

    and ruptures in trends are common.  David   Hume  described this as the problem  of induction – that we can never infer from the past to predict the...2 Moteff, John, Claudia Copeland, and John Fischer (2003);  Cornish, Paul,  David ...Claudia Copeland, and John Fischer (2003);   Moteff, John and Paul Parfomak (2004);  Cornish, Paul,  David  Livingstone, Dave Clemente and Claire Yorke

  16. INOPS Fire internationale casestudier

    DEFF Research Database (Denmark)

    , LONDON, UK: MANAGING THE PARK BY LONG TERM CONTRACTS Authors: Dr Nicola Dempsey, Dr Claudia Martinez Velarde, Mel Burton. University of Sheffield, UK QUEEN ELIZABETH OLYMPIC PARK, LONDON, UK: EXPERIENCES WITH LONG TERM PARTNERSHIP BASED CONTRACTING Authors: Dr Nicola Dempsey, Dr Claudia Martinez Velarde......This case report is a part of a series of case studies in the INOPS project which study experiences with different approaches to contracting out of park and road services in the four countries. The purpose of the case reports is to provide a series of reference cases for comparisons and development...... across the four countries. The reports has been written with the purpose in mind to allow a reader to get detailed insights in the background for decisions, processes and outcomes when park and road services are contracted out by Local Governments. The report contains four case studies: BURGESS PARK...

  17. Verfestigung asymmetrischer Beziehungsstrukturen mittels Gewalt

    Directory of Open Access Journals (Sweden)

    Daniel Osterwalder

    2004-07-01

    Full Text Available Die Arbeit der Historikerin Claudia Töngi dreht sich um verschiedene Formen von Gewalt wie Tötungsdelikte, häusliche und sexuelle Gewalt. Auf der Basis einer umfangreichen Daten- und Quellensammlung aus dem Gerichtsarchiv des Schweizer Kantons Uri (die zudem im Anhang aufgeführt wird zeigt sie, wie sich im 19. Jahrhundert Frauen und Männer zur Anwendung von Gewalt stellten und wie sich Gewaltpraktiken und deren Wahrnehmung im besprochenen Zeitraum verändert haben. Einerseits bringt Claudia Töngi noch unpublizierte Archivakten vor dem Hintergrund sozialgeschichtlicher Fragestellungen zum Sprechen, andererseits ermöglicht sie interessierten Forscher/-innen, die vergleichend zu Gewalt und Delinquenz arbeiten, raschen Zugriff auf die urnerischen Daten. Die Untersuchung wurde als Projekt Nr. 15 im Rahmen des Nationalfondsprogramms „Gewalt im Alltag und organisierte Kriminalität“ (NFP 40; URL: http://www.nfp40.ch, 20.04.2004 durchgeführt.

  18. Resource-Bounded Information Acquisition and Learning

    Science.gov (United States)

    2012-05-01

    sincerely thank Avrim Blum, Sridhar Mahadevan, Arnold Rosen- berg, Richard Lawrence, Claudia Perlich, Andrew McGregor, Gideon Mann, Gerald Tesauro, Laura...entities from the web using unsupervised information extraction. In Web Search and Data Mining. [20] Daskalakis, Constantinos, Karp , Richard M., Mossel...extraction in knowitall. In Proceedings of the International WWW Conference, New York (May 2004), ACM. [29] Etzioni, O., Hanks, S., Jiang, T., Karp , R. M

  19. Goldin and Katz and Education Policy Failings in Historical Perspective

    OpenAIRE

    Arnold Kling; John Merrifield

    2009-01-01

    In The Race Between Education and Technology, Claudia Goldin and Lawrence Katz employ a powerful theoretical framework to investigate how inequality is affected by the interrelation between changes in technology and changes in job-market skills. The investigation is carried out with great vision and a combination of scholarly methods. In this review essay, we embrace the theoretical core of the book, but find a number of problems in the execution. We see a need to distinguish between attendin...

  20. Reducing Uncertainties in Future Climate Projections by Quantifying Human COntributions to 20th Century Climate Change

    Energy Technology Data Exchange (ETDEWEB)

    Gabriele Hegerl and IDAG members

    2011-07-31

    This report focuses on the period to 2010 including, after which the new round of the International Detection and Attribution group, led by Claudia Tebaldi, started. In 2011, some final work on report has been done, and outstanding tasks completed. However, most participants are now working on the new grant and hence the citations and work reported is focusing largely on the regular grant period.

  1. Revivamos nuestra historia

    Directory of Open Access Journals (Sweden)

    Myriam Bautista

    2015-12-01

    Full Text Available El paraíso del diablo. Roger Casement y el informe del Putumayo, un siglo después. Claudia Steiner Sampedro, Carlos Páramo Bonilla, Roberto Pineda Camacho (Compiladores. Universidad de los Andes, Facultad de Ciencias Sociales, Departamento de Antropología; Universidad Nacional de Colombia, Facultad de Ciencias Humanas, Departamento de Antropología, Bogotá, 2014, 462 págs., il.

  2. Ilhas: o começo e o fim do mundo

    Directory of Open Access Journals (Sweden)

    Marilia Teresinha de Sousa Machado

    2015-12-01

    Full Text Available Steven Roger Fischer. Ilhas: de Atlântida a Zanzibar. São Paulo: Editora Unesp, 2014. 432p. [Tradução de Claudia Freire]. ISBN 978-85-393-0550-6. Preço: R$ 65,00. Inclui bibliografia, imagens e índice remissivo. Traduzido do original: Islands: From Atlantis to Zanzibar (London: Reaktion Books, 2012.

  3. Berlinale Kuldkaru jagunes kahe filmi vahel / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2002-01-01

    Berliini 52. filmifestivali tulemustest. Festivali "Panorama Special" kavas olnud Peeter Simmi "Head käed" saavutas hea publikuedu ning jagas sloveenlase Maja Weiss'i filmiga "Piirivalvur" Manfred Salzgeberi auhinda, mis on mõeldud subtiitrite tegemiseks filmi levitamisel euroopa ekraanidele. Kuldkaru jagasid briti Paul Greengrassi "Verine pühapäev" ja jaapanlase Hayao Miyazaki animafilm "Vaimudest viidud". Elutöö-Kuldkarud said Claudia Cardinale ja Robert Altman

  4. formationer

    DEFF Research Database (Denmark)

    Carbone, Claudia

    2009-01-01

    baggrund: Projektets tidslinje: 1. Observerede formationer / fastholdt i fotografier 2. Formuleret projektramme: Beskrivelse til projektet med arbejdstitlen Mellem scape og serialitet. Projektet bliver udført i forlængelse af en langvarig interesse for forholdet mellem kontekst, kortlægning og de...... oprettet et team, der bestod af arkitektstuderende Berith Skinhøj Pedersen, Louise Haugaard Nielsen Torben Lauritsen og Claudia Carbone....

  5. Historical evolution of the concept of anorexia nervosa and relationships with orthorexia nervosa, autism, and obsessive-compulsive spectrum

    OpenAIRE

    Pini, Stefano; Abelli,Marianna; Carpita,Barbara; Dell'Osso,Liliana; Castellini,Giovanni; Carmassi,Claudia; Ricca,Valdo

    2016-01-01

    Liliana Dell’Osso,1 Marianna Abelli,1 Barbara Carpita,1 Stefano Pini,1 Giovanni Castellini,2 Claudia Carmassi,1 Valdo Ricca2 1Psychiatry Section, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 2Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy Abstract: Eating disorders have been defined as “characterized by persistence disturbance of eating or eating-related behavior ...

  6. Peering Through The Surface of a Water War Between China and India

    Science.gov (United States)

    2016-04-04

    human misery. As David Grey , a former senior water advisor for the World Bank, and Clauda Sadoff, a lead economic advisor for the World Bank, put it...1 David Grey and Claudia W. Sadoff, "Sink Or Swim? Water Security for Growth and Development," Water Policy Vol. 9, no. 6...sparked riots. As cited in Rebecca Lowe and Emily Silvester’s report on water shortages that threaten global security, Grey claimed that although

  7. Project for a New Classification of Musical Instruments

    Directory of Open Access Journals (Sweden)

    André Schaeffner

    2017-08-01

    Full Text Available This is an English translation of an article originally published as “Projet d'une classification nouvelle des instruments de musique.” Bulletin du Musée d'Ethnographie du Trocadéro 1, 1931, 21–25. Draft translation: Claudia Riehl and Gerd Grupe, with advice on terminology by Susanne Fürniß, copy-editing: Jessica Sloan-Leitner.

  8. Journal of Mormon History Vol. 38, No. 3, Summer 2012

    OpenAIRE

    2012-01-01

    CONTENTS LETTER --Fitz John Porter’s Letter William P. MacKinnon, vii ARTICLES --Mormonism in Cultural Context: Guest Editors’ Introduction J. Spencer Fluhman, Steven C. Harper, and Jed Woodworth, 1 --A Charmed Life Claudia L. Bushman, 5 --The Hermeneutics of Generosity: A Critical Approach to the Scholarship of Richard Bushman Stuart Parker, 12 --To Mend a Fractured Reality: Joseph Smith’s Project Philip L. Barlow, 28 --The Language of Heaven: Prolegomenon to the Stud...

  9. Vivencias de opresión de mujeres en una cárcel municipal /

    OpenAIRE

    Salinas Boldo, Claudia

    2012-01-01

     tesis que para optar al grado de Doctora en Antropología presenta Claudia Salinas Boldo ; tutora de tesis Dra. Martha Patricia Castañeda Salgado, asesoras Dra. Norma Blazquez Graff, Dra. María Eugenia D’Aubeterre Buznego326 páginasDoctorado en Antropología UNAM, Facultad de Filosofía y Letras, 2012

  10. Il fascismo e gli Italian Studies in Gran Bretagna: Le strategie e i risultati della propaganda (1921–40)

    OpenAIRE

    Colacicco, Tamara

    2016-01-01

    Questo intervento si inserisce nel solco di esplorazioni storiografiche promosse ad esempio da Aldo Berselli, Roberta Suzzi Valli e Claudia Baldoli. Questi studiosi si sono soffermati sui temi della propaganda fascista in area britannica oppure sulle visioni sviluppate dall'Inghilterra nei confronti di Benito Mussolini. Questo saggio intende principalmente offrire un contributo per colmare una lacuna storiografica. Infatti, gli sporadici volumi della letteratura secondaria reperibili su quest...

  11. Women’s Peace Movements and Pioneers of Social Work at the Dawn of World War I

    Directory of Open Access Journals (Sweden)

    Daniela Joya Valbuena

    2017-01-01

    Full Text Available Reseña del capítulo “Women’s Peace Movements and Pioneers of Social Work at the Dawn of World War I” de Gaby Franger en Peacebuilding-Gender-Social Work: International Human rights Dialogue: Celebrating the 100th Anniversary of the Women’s Peace Congress. Gaby Franger y Claudia Lohrenscheit (Editoras. Oldenburg: Paulo Freire Verlag. 2015, 31-48 pp.

  12. Verfestigung asymmetrischer Beziehungsstrukturen mittels Gewalt The Solidification of Asymetrical Structures of Relationships through Violence

    Directory of Open Access Journals (Sweden)

    Daniel Osterwalder

    2004-07-01

    Full Text Available Die Arbeit der Historikerin Claudia Töngi dreht sich um verschiedene Formen von Gewalt wie Tötungsdelikte, häusliche und sexuelle Gewalt. Auf der Basis einer umfangreichen Daten- und Quellensammlung aus dem Gerichtsarchiv des Schweizer Kantons Uri (die zudem im Anhang aufgeführt wird zeigt sie, wie sich im 19. Jahrhundert Frauen und Männer zur Anwendung von Gewalt stellten und wie sich Gewaltpraktiken und deren Wahrnehmung im besprochenen Zeitraum verändert haben. Einerseits bringt Claudia Töngi noch unpublizierte Archivakten vor dem Hintergrund sozialgeschichtlicher Fragestellungen zum Sprechen, andererseits ermöglicht sie interessierten Forscher/-innen, die vergleichend zu Gewalt und Delinquenz arbeiten, raschen Zugriff auf die urnerischen Daten. Die Untersuchung wurde als Projekt Nr. 15 im Rahmen des Nationalfondsprogramms „Gewalt im Alltag und organisierte Kriminalität“ (NFP 40; URL: http://www.nfp40.ch, 20.04.2004 durchgeführt.The work of the historian Claudia Töngi focuses on different forms of violence such as killing crimes and domestic and sexual violence. Based on a broad collection of data and primary documents from the court archive of the Swiss canton of Uri (which is provided in the appendix, she illustrates how women and men viewed the use of violence in the 19th century and how practices of violence and their perceptions were transformed in the time-period considered. On the one hand, Claudia Töngi brings the still unpublished archival documents against the backdrop of social-historical questions to light. On the other hand, she allows interested researchers who work comparatively on violence and delinquency quick access to data. The study was carried out as project number 15 within the framework of the National Fonds Program “Violence in Everyday Life and Organized Criminality" (NFP 40; http://www.nfp40.ch, 20.04.2004.

  13. Debates en torno de la anticoncepción de emergencia en Chile

    OpenAIRE

    Brown, Josefina Leonor

    2007-01-01

    El artículo trata del libro Voces en Emergencia: el discurso conservador y la píldora del día después, escrito por la investigadora de FLACSO, Claudia Dides, da cuenta del recorrido de los debates en la prensa escrita de su país, Chile, en relación con la política de anticoncepción de emergencia allí implementada.

  14. Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation

    OpenAIRE

    Di Marco, Maria

    2009-01-01

    Mariagrazia Di Marco1, Shaharum Shamsuddin2, Khairunisak Abdul Razak3, Azlan Abdul Aziz4, Corinne Devaux1, Elsa Borghi1, Laurent Levy1, Claudia Sadun51Nanobiotix, Paris, France; 2School of Health Sciences, Health Campus Universiti Sains Malaysia, Kelantan, Malaysia; 3School of Materials and Mineral Resources Engineering, Engineering Campus, 4School of Physics, Universiti Sains Malaysia, Penang, Malaysia; 5Department of Chemistry, Sapienza, University of Rome, Rome, ItalyAbstract: The latest d...

  15. High frequency equipment promotes antibacterial effects dependent on intensity and exposure time

    OpenAIRE

    Wietzikoski Lovato,Evellyn Claudia; Gurgel Velasquez,Patrícia Amaral; Dos Santos Oliveira,Cristiana; Baruffi,Camila; Anghinoni,Thais; Machado,Raquel Costa; Lívero,Francislaine Aparecida dos Reis; Sato,Samantha Wietzikoski; Martins,Lisiane de Almeida

    2018-01-01

    Evellyn Claudia Wietzikoski Lovato,1 Patrícia Amaral Gurgel Velasquez,1 Cristiana dos Santos Oliveira,1 Camila Baruffi,1 Thais Anghinoni,1 Raquel Costa Machado,1 Francislaine Aparecida dos Reis Lívero,2 Samantha Wietzikoski Sato,1 Lisiane de Almeida Martins1 1Laboratory of Microbiology of Natural Products, Paranaense University, Umuarama, Brazil; 2Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil Background: The indiscriminat...

  16. Los trabajos domésticos y la proveeduría: entre permanencias, conflictos y cambios

    OpenAIRE

    Puyana Villamizar, Yolanda; Mosquera Rosero, Claudia

    2002-01-01

    El texto de Yolanda Puyana y Claudia Mosquera hace parte de una amplia investigación sobre cambios en las representaciones sociales de la maternidad y la paternidad; devela mayores permanencias que cambios alrededor de los repartos entre hombres y mujeres en las prácticas relacionadas con el trabajo doméstico y la proveeduría, aún en estos comienzos del Siglo XXI.

  17. Abnormalities in Human Brain Creatine Metabolism in Gulf War Illness Probed with MRS

    Science.gov (United States)

    2013-10-01

    and Brain Sciences Board Chair Debbie Francis Board Vice Chair Bob Wilbur Founding Chair Shelia Schlosberg Leadership Council Sallie and...Frederic Asche, Jr. Claud ia and Dennis Berman Toni C. Brinker Jean Ann Brock Dianne Cash Cullum Clark Mary Anne Cree Teresa and David Disiere...Boone Pickens Terry and Bob Rowling Annette and Harold Simmons Jane and Bud Smith Jill Smith Claudia and Gerald Stool Dee and Charles Wyly The

  18. Lift the quilt in case of atrial fibrillation and disc prolapse

    OpenAIRE

    Bastovansky, Adam; Ziegler, Kathrin; Stöllberger, Claudia; Finsterer, Josef

    2012-01-01

    Adam Bastovansky,1 Kathrin Ziegler,2 Claudia Stöllberger,2 Josef Finsterer31Department of Radiology, 2Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria; 3Danube University Krems, Krems, AustriaBackground: Peripheral embolism to the lower extremities may mimic disc prolapse with severe consequences.Case report:  A 71-year-old male with a history of chronic alcoholism developed low back pain radiating to both lower extremities in a nonradicular distribution an...

  19. Escalonando la agroecologia : Procesos y aprendizajes de cuatro ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    1 janv. 2007 ... Claudia Ranaboldo est chercheure principale au Centro Latinoamericano para el Desarrollo Rural (Rimisp) et coordonne le projet de développement territorial rural à l'aide de services et de produits ayant une identité. Carlos Venegas est directeur régional pour le Centro de Educación y Tecnología (CET) ...

  20. Browse Author Index

    African Journals Online (AJOL)

    Items 51 - 100 of 110 ... Ferdausi, D · Fernandes, George Pimentel · Fernandes, Sara · Fernandez-Arche, MA · Fernando, WS · Fernández-Martín, Karla · Fernández-Zuñiga, Eunice A. Fett, Carlos Alexandre · Fett, Waléria Christiane Rezende · Fidahusein, DS · Figueiredo, Claudia · Filali, Ayoub · Fleischer, TC · Fleischer, TC

  1. The Journal of Healthcare, Science and the Humanities. Volume 2, Number 2, 2012

    Science.gov (United States)

    2012-01-01

    Sandra Titus, PhD, Vice-Chair Members Tim Atkinson, EdD Jere M. Boyer, PhD Philip A. Cola , MA Kendall Egan, MD Mark Flores, MBA Darlene Gilson Mary I...Health Advisors as Research Partners: Utilizing Community- Based Participatory Research to Address Cancer Prevention and Control in African American...and submariners. Claudia M. Hardy, BA, MPA is the Program Director for the Deep South Network for Cancer Control; a five-year National Cancer

  2. Invertebrate neuroscience and CephsInAction at the Mediterranean Society for Neuroscience Meeting Cagliari 2015.

    Science.gov (United States)

    Holden-Dye, Lindy; Fiorito, Graziano; Ponte, Giovanna

    2015-12-01

    Invertebrate neuroscience, and in particular cephalopod research, is well represented in the Mediterranean region. Therefore, the recent meeting of the Mediterranean Society for Neuroscience in Santa Margherita di Pula, Sardinia (12-15 June 2015) provided an excellent opportunity for invertebrate contributions. Furthermore, the Chair of an EU COST Action for cephalopod research (FA1301; www.cephsinaction.org ), Giovanna Ponte, together with Graziano Fiorito from the Stazione Zoologica, Naples, aligned a meeting of research groups working in the field of cephalopod neurophysiology from across Europe to coincide with the neuroscience meeting. This provided an exciting forum for exchange of ideas. Here we provide brief highlights of both events and an explanation of the activities of the COST Action for the broader invertebrate neuroscience community.

  3. Marco Benoît Carbone, Tentacle erotica. Orrore, seduzione, immaginari pornografici

    Directory of Open Access Journals (Sweden)

    Luca Zenobi

    2015-05-01

    Full Text Available “Mimesis Media/Eros. Sessualità, tecnologia, rappresentazioni” è la collana diretta da Giovanna Maina e Federico Zecca, due giovani studiosi che, assieme ad Enrico Biasin (Porno espanso, Mimesis, 2011, Porn after Porn, Mimesis International, 2014, hanno avuto il merito di “sdoganare” i porn studies in Italia e, soprattutto, di averlo fatto in una maniera tale da renderli un componente di primo livello del dibattito scientifico, grazie alla collaborazione con studiosi internazionali e a un attento e competente lavoro su categorie che fanno parte oramai da qualche anno del panorama culturale contemporaneo. I workshop sulla pornografia organizzati all’interno delle attività del FilmForum di Udine e Gorizia sono parte integrante e creativa di un laboratorio che in breve tempo ha scalfito le rigide barriere disciplinari dell’accademia italiana coinvolgendo studiosi di discipline e campi diversi.

  4. Survivability Mode and Extreme Loads on the Mooring Lines of the Wave Dragon Wave Energy Converter

    DEFF Research Database (Denmark)

    Parmeggiani, Stefano; Kofoed, Jens Peter

    This report is a product of the cooperation agreement between Wave Dragon and Aalborg University regarding phase 2 of the development of the Wave Dragon Wave Energy Converter. The research is carried out by testing the 1:51.8 scale model of the Wave Dragon, aiming at the assessment...... of the survivability of the device in extreme waves and evaluation of the design loads for the mooring component. The testing has been carried out in October 2010 by PhD student Stefano Parmeggiani and Master students Giovanna Bevilacqua and Giacomo Girardi Ferruzza at the Hydraulic and Coastal Laboratories...... of the department of Civil Engineering at Aalborg University. The outcome of the research will be used as input for future research work aimed at the design of the mooring system and the certification of the structural design for the full scale Wave Dragon demonstrator....

  5. Clinical validity of MR based program for analysis of fluid/brain index of posterior cranial fossa structures in patients with spinocerebellar ataxia

    International Nuclear Information System (INIS)

    Boguslawska, R.; Lechowicz, W.

    2008-01-01

    Spinocerebellar ataxia type 1 (SCA1) and type 2 (SCA2) belong to the group of neurodegenerative disorders of autosomal dominant inheritance, genetically and clinically heterogeneous, caused by CAG trinucleotide repeat expansion, which leads to productions of protein carrying the abnormal polyglutamine chain (polyQ). Molecular abnormalities cause degenerative changes - atrophy of posterior cranial fossa structures. The clinical symptoms typical of this disorder include progressive gait and limb ataxia, dysarthria, occulomotor disturbances, pyramidal tract and peripheral nerves involvement. The aim of the study is to evaluate the usefulness of a computer program prepared in our department for volumetric measurements of posterior cranial fossa structures (the pons, vermis and cerebellar hemispheres) in a group of SCA patients. MR examinations of 22 patients suffering from SCA were used to calculate the value of fluid/brain index of posterior cranial fossa structures and compared with the results of group of 10 healthy volunteers. The degree of atrophy of posterior cranial fossa structures can be objectively evaluated by special volumetric measurements. We found fluid/brain index (FBI) of posterior cranial fossa structures in group of SCA patients to vary from 0.1411 to 0.3929 (mean 0.2456 SD±0.601). 1. MR-based calculation of fluid/brain index of posterior fossa structures is a valuable tool for morphological assessment of SCA-related changes in brain structures. 2. The presented software enables objective evaluation of the course and stage of posterior fossa structures atrophy. 3. Our self-made computer program to calculate the fluid/brain index of posterior cranial fossa structures is easy to use on a personal computer- it is a good tool in everyday radiological practice. (author)

  6. Obraz dospívání a rané dospělosti v současném románu a povídkách pro mládež a mladé dospělé Ivy Procházkové, Gudrun Pausewangové a Claudie Ruschové (komparace vybraných děl české a německé literatury)

    OpenAIRE

    Babíčková, Karolína

    2017-01-01

    The master thesis focuses on the literary analysis and comparison of four books for young adults written by different authors. Two of the compared works are novels Eulengesang and Carolina: Ein knapper Lebenslauf by Iva Procházková, originally a Czech author and representative of a so called migrant literature. The thesis deals also with the novel Die Wolke by Gudrun Pausewang and the short story collection Meine freie deutsche Jugend written by Claudia Rusch. The main aim of the thesis is to...

  7. Um fim à negligência em relação aos problemas da mulher negra!

    Directory of Open Access Journals (Sweden)

    Claudia Jones

    2017-10-01

    Full Text Available O artigo é a tradução de um ensaio publicado originalmente em 1949, pela intelectual e ativista negra Claudia Jones na revista Political Affairs. No ensaio, Jones demonstra as origens e as múltipmas dimensões da dinâmica do sistema de opressão a que eram submetidas mulheres negras e critica a inabilidade dos comunistas estadunidenses em mobilizá-las. Ao argumentar que as mulheres negras compunham a fração superexplorada da classe trabalhadora, a autora as posiciona como parecela central da militância internacional contra o fascismo e o imperialismo.

  8. Browse Author Index

    African Journals Online (AJOL)

    A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. A. Amalu, SN · Amambua, Alfred N. Aman, A · Amanchi, NR · Amani, N'Guessan Georges · Amanke, G · Amanlou, H · Amanullah, Malik · Amao, O A · Amao, OA · Amar, Amouri Adel · Amar, Raja Ben · Amara, Amro A · Amara, Slim H. Amarachi, S · Amaral, Ana Claudia ...

  9. Progress in biogas II - Biogas production from agricultural biomass and organic residues. Pt. 2. Proceedings; Progress in Biogas II - Biogasproduktion aus landwirtschaftlicher Biomasse und organischen Reststoffen. T. 2. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-08-12

    Within the International Congress at the University of Hohenheim (Stuttgart, Federal Republic of Germany) from 29th March to 1st April, 2011, beside numerous poster presentations the following lectures were held: (1) Coverage of digestate storage tanks: why it is necessary and technical solutions (Paolo Balsari); (2) Digestate Standard in the United Kingdom (David Collins); (3) Unraveling the causes of nitrogen losses from the bioslurry and strategies for value addition (Steven Nyanzi); (4) Biological nitrogen removal from the liquid phase of anaerobic digestate of livestock effluents and energy crops (Francesco Fatone); (5) Ammonium loss of digestate during drying (Claudia Maurer); (6) Innovative process of gaining efficient fertilizers from digestates (Daniel Schloz).

  10. Book review: Euro-Latin American cooperation and relations and South-South cooperation

    Directory of Open Access Journals (Sweden)

    Jairo Agudelo Taborda

    2014-09-01

    Full Text Available Reviewed books: Tassara, Carlo Cooperación para el desarrollo, relaciones internacionales y políticas públicas: Teorías y prácticas del diálogo euro-latinoamericano. Ediciones UNAULA, 2013. 302 págs. Marín Aranguren, Erli Margarita y Ro­mero Amaya, María Claudia (eds. Cuando el Sur piensa el Sur: Los giros de la cooperación al desarrollo. Univ. Externado de Colombia, 2013. 362 págs.

  11. Experimental Design for CMIP6: Aerosol, Land Use, and Future Scenarios Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Arnott, James [AGCI

    2015-10-30

    The Aspen Global Change Institute hosted a technical science workshop entitled, “Experimental design for CMIP6: Aerosol, Land Use, and Future Scenarios,” on August 3-8, 2014 in Aspen, CO. Claudia Tebaldi (NCAR) and Brian O’Neill (NCAR) served as co-chairs for the workshop. The Organizing committee also included Dave Lawrence (NCAR), Jean-Francois Lamarque (NCAR), George Hurtt (University of Maryland), & Detlef van Vuuren (PBL Netherlands Environmental Change). The meeting included the participation of 22 scientists representing many of the major climate modeling centers for a total of 110 participant days.

  12. Agroecología : Bases teóricas para el diseño y manejo de agroecosistemas sustentables

    OpenAIRE

    Sarandón, Santiago Javier; Flores, Claudia Cecilia

    2014-01-01

    El libro Agroecología y Desarrollo Sustentable, editado por Santiago J. Sarandon y Claudia Cecilia Flores de La Facultad de Ciencias Agrarias y Forestales de la UNLP, viene a llenar un gran vacío en nuestra literatura agroecológica al entregarnos un libro adaptado a las necesidades del currículo agronómico que se desarrolla en la mayoría de las Universidades e Instituciones de Educación Agropecuaria en América Latina. El libro se suma a la escuela de pensamiento que define a la Agroecología c...

  13. Reseñas de Libros

    Directory of Open Access Journals (Sweden)

    Doctora Claudia Cabrera

    2009-10-01

    Full Text Available Reseñas de los siguientes libros:Desarrollo: Crónica de un desafío permanente Víctor Bretón Solo de ZaldívarEl pueblo de Quito. 1690-1810. Demografía, dinámica sociorracial y protesta popular. Sofía LuzuriagaOtras naciones. Jóvenes, transnacionalismo y exclusión. Isabel RamosProfesora-investigadora de FLACSO-EcuadorLo público de la educación pública: la reforma educativa de los noventa en Argentina. Doctora Claudia Cabrera

  14. Mussolini Person of Letters

    Directory of Open Access Journals (Sweden)

    Roberto Zapperi

    2013-07-01

    Full Text Available The essay reconstructs Mussolini's passion for literature. In 1909 he published a serial novel entitled “The Cardinal's lover. Claudia Particle”. After the Mussolini's rise to power, Giovacchino Forzano acted as a ghostwriter for him in the writing of three dramas. Mussolini’s knowledge of more or less classic authors in literature becomes an essential part in the construction of the rhetoric of the leader both in public discourses and in his well-known slogans. At the same time, Mussolini’s attempt to become a renowned author was functional to the construction of the character of the Duce.

  15. Publicidade e ética: um estudo da construção da imagem da mulher

    Directory of Open Access Journals (Sweden)

    Elizabeth Moraes Gonçalves

    2010-02-01

    Full Text Available O texto propõe uma reflexão sobre a ética da responsabilidade na publicidade veiculada nas revistas Claudia e Nova. Trata-se de uma pesquisa descritiva, resultante da leitura dos anúncios selecionados, subsidiada por teóricos da Análise do Discurso da linha francesa, que busca averiguar como a mulher é representada. Constatou-se que no contexto da sociedade contemporânea o retrato da mulher como sedutora ainda está presente, mesmo que em vários momentos ela apareça como protagonista de sua própria vida.

  16. Social media fundamentals, models, and ranking of user-generated content

    CERN Document Server

    Wyrwoll, Claudia

    2014-01-01

    The increasing amount of user-generated content available on social media platforms requires new methods to find, evaluate, and to compare. To this day, existing ranking approaches to user-generated content do not allow for evaluation across platforms by exploiting its metadata. User-generated content, such as blog postings, forum discussions, shared videos etc. does however contain information that can be used for its evaluation independent of specific search interests. Claudia Wyrwoll presents a query- and language-independent ranking approach that allows for global evaluation of user-genera

  17. Análise de influências ambientais na calibração de antenas de receptores GPS

    OpenAIRE

    Movio Huinca, Suelen Cristina

    2014-01-01

    Coorientador: Prof. Dr. Wilson Alcântara Soares Orientadores : Profª Drª Claudia Pereira Krueger Tese (doutorado) - Universidade Federal do Paraná, Setor de Ciências da Terra, Programa de Pós-Graduação em Ciências Geodésicas. Defesa: Curitiba, 31/07/2014 Inclui referências Resumo: As variações do centro de fase das antenas receptoras dos sinais GPS são uma das fontes de erro atuantes no posicionamento por satélites GPS com acurácia. Esse erro pode ser minimizado realizando calibra...

  18. Legacy Clinical Data from the Mission Connect Mild TBI Translational Research Consortium

    Science.gov (United States)

    2017-10-01

    INVESTIGATOR: Claudia Robertson, MD CONTRACTING ORGANIZATION: Baylor College of Medicine Houston, TX 77024 REPORT DATE: October 2017 TYPE OF REPORT...WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Baylor College of Medicine One Baylor...DATA UPLOADED TO FITBIR  Totals to date in Project  35,351   1,413     7  ROWS  EXISTING     NEW  UDE  1st Quarter Sep‐Dec 2016  4,511  154  7   GCS

  19. Tonemic Substitution

    African Journals Online (AJOL)

    Ezenwafor

    15 févr. 2006 ... l'amour de Bianca (16ans), la sœur cadette d'Olga. Au début des années 1980 aux Etats-Unis, quelques philosophes féministes telles, Anne Ferguson, Claudia Gard et Marilyn. Frye dans leurs études critiques sur Le deuxième sexe avaient reproché à Simone de Beauvoir d'avoir nié son identité lesbienne ...

  20. Identidade e subjetividade: uma reflexão sobre o que é ser mulher

    OpenAIRE

    Menezes, Tayana Dias

    2016-01-01

    Através de uma análise sóciopragmática do discurso, observo como a identidade da mulher é (re)construída pelas revistas que são direcionadas para o público feminino. O corpus da pesquisa foi composto pelas revistas Claudia, Gloss, ambas do ano de 2009 e 2010. A pesquisa trabalha com o conceito de identidade não como essência ou um fato da natureza, mas como construções sociais compostas por elementos diversos ou atributos emergentes da interação social entre o sujeito e o mundo, incluem dimen...

  1. El impacto de las redes sociales virtuales en la identidad y subjetividad de los adolescentes /

    OpenAIRE

    Correa González, Eleazar

    2011-01-01

     tesis que para obtener el grado de Doctor en Pedagogía, presenta Eleazar Correa González ; asesor Concepción Barrón Tirado, Guillermo González Rivera, Marco Antonio Jiménez García, Patricia Mar Velasco, Claudia Pontón Ramos. vii, 355 páginas : ilustraciones, diagramas, fotografías. Doctorado en Pedagogía UNAM, Facultad de Filosofía y Letras, 2011

  2. VI Actas Congreso. Miedos, culpas, violencias invisibles y su impacto en la vida de las mujeres: ¡A vueltas con el amor!

    OpenAIRE

    Gil Gómez, Alicia; Escrig Gil, Gemma; Forcada Martínez, Águeda

    2010-01-01

    ÍNDICE. Presentación,ESPERANZA BOSCH FIOL. Introducción poética, PACA GABALDÓN, CLAUDIA GRAVI Y Mª LUISA SAN JOSÉ. Justo el amor, MARÍA XOSÉ AGRA ROMERO. I. CONFERENCIAS El género en cuestión. Modelos imposibles y modelos perversos,DOLORES JULIANO CORREGIDO. La propia identidad y las relaciones de amor en la adolescencia, AURORA LEAL GARCÍA Feelings of fear and guilt among women in conflicts and wars.Miedos y culpas de mujeres en situaciones de conflictos y de guerra, RAN...

  3. [Eesti Kunstiakadeemia uue hoone rahvusvaheline arhitektuurivõistlus] : EKA maja

    Index Scriptorium Estoniae

    2008-01-01

    Žürii hääletustulemused ja hinnangud. I preemia - "Art Plaza", taani arhitektid Uffe Leth Laursen, Tue Hesselberg Foged, Karsten Gori, Sinus Lynge, Greta Tedje, Simon Sorensen, Lawrence Aeberhard, Lyndal Brown, Morgan Jacobsen (AB Sea + Effekt). II - "TLN 247", Hollandi AB NAT Architecten bv, M. van Zijl, V. van der Klei, F. A. van Manen, B. de Graaf, T. M. van Dijkhuizen, S. van der Meer, D. Awe, N. Limburg, J. Kuilman. III - "Arts Factory", Portugali AB Neralp-Arquitectura Engenharia e Construcoes Lda, Paulo Sergio Goncalves Teixeira de Sousa. Ergutuspreemia - "Publicsection", Hollandi AB BOARD, Bernd Upmeyer, kaastöö: Claudia Hess ja "Sashimi", jaapani arhitekt Francois Blanciak

  4. Erratum to: Tomotherapy PET-guided dose escalation--A dosimetric feasibility study for patients with malignant pleural mesothelioma.

    Science.gov (United States)

    Maggio, Angelo; Cutaia, Claudia; Di Dia, Amalia; Bresciani, Sara; Miranti, Anna; Poli, Matteo; Delmastro, Elena; Garibaldi, Elisabetta; Gabriele, Pietro; Stasi, Michele

    2015-12-01

    Unfortunately, erroneous author affiliations were published in the article "Tomotherapy PET-guided dose escalation – A dosimetric feasibility study for patients with malignant pleural mesothelioma". The correct list of author affiliations reads as follows: Angelo Maggio 1, Claudia Cutaia 1, Amalia Di Dia 1, Sara Bresciani 1, Anna Miranti 1, Matteo Poli 1, Elena Delmastro 2, Elisabetta Garibaldi 2, Pietro Gabriele 2 and Michele Stasi 1. 1: Medical Physics Department, Candiolo Cancer Institute – FPO, IRCCS, Turin, Italy. 2: Radiotherapy Department, Candiolo Cancer Institute – FPO, IRCCS, Turin, Italy. We apologize for any inconveniences caused.

  5. Pomological Traits, Sensory Profile and Nutraceutical Properties of Nine Cultivars of Loquat (Eriobotrya japonica Lindl.) Fruits Grown in Mediterranean Area.

    Science.gov (United States)

    Gentile, C; Reig, C; Corona, O; Todaro, A; Mazzaglia, A; Perrone, A; Gianguzzi, G; Agusti, M; Farina, V

    2016-09-01

    In this paper the diversity of fruit quality within nine loquat cultivars, including five international affirmed cultivars (Algerie, Golden Nugget, Peluche, Bueno, El Buenet) and four local cultivars (Sanfilippara, Nespolone di Trabia, BRT20 and Claudia), were investigated in order to discriminate the variation in pomological characteristics, sensory profile, and antioxidant properties. Finally, to evaluate potential bioactivity, antiproliferative activity of hydrophilic extracts from loquat fruits was assessed, at dietary relevant concentrations, against three human epithelial cell lines. Even though the international cultivars confirmed an appropriate level of commercial qualities in association to high levels in antioxidant compounds, the local cultivars revealed the best performances in a wide range of chemical-physical and sensory characteristics. Concerning bioactivity, our results indicate that hydrophilic extracts from all tested cultivars showed concentration-dependent antiproliferative activity with a significant variability of effects between different cell lines and between different cultivars. HeLa cells, the most sensitive and hydrophilic extracts from Peluche, showed the highest inhibitory effect followed by Nespolone di Trabia and Claudia. The results of this trial provide useful information on the pomological traits and the not yet known specific nutritional and functional properties of loquat fruits. Our data, besides helping to promote specific local cultivars, could serve to establish a database that will permit to improve the utilization of specific genetic resources in breeding programs.

  6. Entre dos exilios: Cesare Civita, un editor italiano en Buenos Aires, desde la guerra mundial hasta la dictadura militar (1941- 1976

    Directory of Open Access Journals (Sweden)

    Scarzanella, Eugenia

    2009-04-01

    Full Text Available This paper deals with the history of an Argentinian publishing house called Editorial Abril, which was founded in 1941 by Cesare Civita, a Jewish immigrant who left Italy after the «race laws» approval. Abril published cartoons (Donald Duck, photo novels (Idilio, women’s magazines (Claudia and news magazines (Panorama. Abril was a family business which knew how to use a wide relation network in Argentina, Italy and the United States. The history of this publishing house ends with Cesare Civita’s new exile in 1976. The material used includes file sources, testimonies, journals and books.

    El artículo trata de la historia de una editorial argentina, la Editorial Abril creada en 1941 por Cesare Civita, un inmigrante judío que abandonó Italia después de la aprobación de las «leyes raciales». Abril publicaba historietas (El Pato Donald, fotonovelas (Idilio, revistas Femeninas (Claudia y de actualidad (Panorama. Abril era una empresa familiar que supo utilizar una vasta red de relaciones en la Argentina, Italia y los Estados Unidos. La historia de la Editorial termina con un nuevo exilio de Cesare Civita en 1976. Se utilizan: fuentes de archivo, testimonios, revistas y libros.

  7. Elusive Justice, Changing Memories and the Recent Past of Dictatorship and Violence in Uruguay: An Analysis of the 2012 Public Act in the Gelman Case

    Directory of Open Access Journals (Sweden)

    Francesca Lessa

    2014-09-01

    Full Text Available This article examines the Public Act of Acknowledgment of International Responsibility and Recovery of the Memory of María Claudia García de Gelman held in the Uruguayan parliament on 21 March 2012 through a theoretical framework of memory narratives. The Inter-American Court of Human Rights ordered Uruguay to hold the Public Act as part of its February 2011 ruling in the Gelman v. Uruguaycase, which condemned its failure to investigate and prosecute individuals responsible for disappearing María Claudia García de Gelman and illegally adopting her baby daughter Macarena, while denying her knowledge of her true identity for over two decades. The Public Act was a memorialising event intended as an act of reparation, which also triggered irruptions of memory in Uruguay, resurfacing memory debates and discussions about the recent past of dictatorship and violence. The Public Act exposed once again the continued antagonisms between memory narratives of violence and justice that have existed in the Uruguayan political and social landscape since 1985. While the Act was an expression of the “state terrorism” narrative, its unfolding resulted in the resurfacing of narratives of “war” and “two demons” in the social and political arenas and of new interpretations of these narratives in light of events and politics in 2012.

  8. Homenagem a colette pétonnet

    Directory of Open Access Journals (Sweden)

    Claudia Fonseca

    2014-06-01

    Full Text Available O seminário "Les sentiers de l'ethnologie urbaine, avec Colette Pétonnet" ("Pistas da etnologia urbana, com Colette Petonnet", realizado entre 3 e 4 de outubro de 2013, no Muséum National d'Histoire Naturelle - Paris, reuniu diversos pesquisadores para uma homenagem póstuma a esta precursora da etnologia em meio urbano, fundadora, com Jacques Gutwirth, do Laboratoire d'Anthropologie Urbaine do Centre National de Recherche Scientifique (LAU/CNRS. Este artigo é uma tradução do paper enviado por Claudia Fonseca, ex-orientanda da homenageada, apresentado, na ocasião, em forma de um vídeo, produzido em conjunto com Claudia Turra Magni e Mauro Bruschi, sob o título Colette Pétonnet au Brésil: les effets pédagogiques d'un exercice ethnographique. Aqui, as autoras evocam as marcas e repercussões dos ensinamentos da mestra, a partir de sua estada no Brasil, na última década do século passado.

  9. A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts

    Directory of Open Access Journals (Sweden)

    Dell’Osso L

    2016-07-01

    Full Text Available Liliana Dell’Osso, Claudia Del Grande, Camilla Gesi, Claudia Carmassi, Laura Musetti Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: Increasing evidence highlights bipolar disorder as being associated with impaired neurogenesis, cellular plasticity, and resiliency, as well as with cell atrophy or loss in specific brain regions. This has led most recent research to focus on the possible neuroprotective effects of medications, and particularly interesting findings have emerged for lithium. A growing body of evidence from preclinical in vitro and in vivo studies has in fact documented its neuroprotective effects from different insults acting on cellular signaling pathways, both preventing apoptosis and increasing neurotrophins and cell-survival molecules. Furthermore, positive effects of lithium on neurogenesis, brain remodeling, angiogenesis, mesenchymal stem cells functioning, and inflammation have been revealed, with a key role played through the inhibition of the glycogen synthase kinase-3, a serine/threonine kinase implicated in the pathogenesis of many neuropsychiatric disorders. These recent evidences suggest the potential utility of lithium in the treatment of neurodegenerative diseases, neurodevelopmental disorders, and hypoxic–ischemic/traumatic brain injury, with positive results at even lower lithium doses than those traditionally considered to be antimanic. The aim of this review is to briefly summarize the potential benefits of lithium salts on neuroprotection and neuroregeneration, emphasizing preclinical and clinical evidence suggesting new therapeutic potentials of this drug beyond its mood stabilizing properties. Keywords: bipolar disorder, GSK-3, neurodegeneration, neurogenesis, neurodevelopmental disorders

  10. IDENTIFICATION OF Acacia mangium PROVENANCES FOR SOLID-WOOD FOREST PLANTATIONS

    Directory of Open Access Journals (Sweden)

    Nurhasybi Nurhasybi

    2009-06-01

    Full Text Available Provenance trial is a planting test aimed at fi nding the best provenance for establishing forest plantations. Such best provenance depends on the type of fi nal harvest or yield expected.  The objective of this research was to identify A. mangium provenances that were suitable for forest plantation producing solid woods for construction and furniture. A total of 225 samples of 15 provenances from Papua New Guinea and Australia were planted in three blocks in Parungpanjang, Bogor, West Java. The measured parameters included tree height, clear bole height, stem diameter, tree volume, stem form, branching habit, and crown form. Bi-plot analysis indicated that Kini WP, Keru Village WP, Derideri R. Morehead, and Claudia River were the best provenances in terms of productivity. Correspondence analysis showed that almost all provenances were equally good in stem form, but they varied in branching system as well as crown form.  Provenances Kini WP, Keru Village WP, Kiriwo/Serisa WP, and Bimadebun Village possessed the better branching habit.  In terms of crown form provenances Dimisi Village WP, Kiriwo/Serisa WP, and Derideri R. Morehead exhibited a good performance. In general, fi ve provenances, i.e. Kini WP, Keru Village WP, Derideri R. Morehead, Kiriwo/Serisa WP, and Claudia River were considered appropriate for seed sources supplying seeds for industrial plantation development intended to produce construction and furniture material.

  11. Emerging perspectives on laminopathies

    Directory of Open Access Journals (Sweden)

    Lattanzi G

    2016-04-01

    Full Text Available Giovanna Lattanzi,1,2 Sara Benedetti,3 Maria Rosaria D’Apice,4 Lorenzo Maggi,5 Nicola Carboni,6 Emanuela Scarano,7 Luisa Politano8 1National Research Council of Italy, Institute for Molecular Genetics (CNR-IGM, Unit of Bologna, 2Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, 3Laboratory of Clinical Molecular Biology and Cytogenetics, San Raffaele Scientific Institute, Milan, 4Fondazione Policlinico Tor Vergata, Rome, 5Neuromuscular Diseases and Neuroimmunology Unit, IRCCS Neurological Institute C Besta, Milan, 6Division of Neurology, Hospital San Francesco, Nuoro, 7Pediatric Endocrinology and Rare Diseases Unit, Department of Pediatrics, S Orsola-Malpighi University Hospital, University of Bologna, Bologna, 8Department of Experimental Medicine, Cardiomyology and Medical Genetics, Second University of Naples, Naples, Italy Abstract: Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches. Keywords: lamin A/C, emerin, laminopathies, Emery–Dreifuss muscular dystrophy, Hutchinson–Gilford progeria

  12. Ciné Club

    CERN Multimedia

    Ciné Club

    2010-01-01

    Thursday 23 September 2010 at 20:30 CERN Main Auditorium Lock, Stock and Two Smoking Barrels By: Guy Ritchie (UK, 1998) 107 min With/avec: Jason Flemyng, Dexter Fletcher, Nick Moran, Jason Statham   Four London working class stiffs pool their money to put one in a high stakes card game, but things go wrong and they end up owing half a million pounds and having one week to come up with the cash. Overhearing their neighbours in the next flat plotting to hold up a group of out-of-their-depth drug growers, our heros decide to stitch up the robbers in turn. In a way the confusion really starts when a pair of antique double-barrelled shotguns go missing in a completely different scam.   Original version english with english subtitles Entrance : 2 CHF Projection from DVD http://cineclub.web.cern.ch/Cineclub/   Thursday 30 September 2010 at 20:30 CERN Main Auditorium Facing Windows / La finestra di fronte By/de : Ferzan Ozpetek (Italy, 2003) 106 min With/avec: Giovanna Mezz...

  13. [The guiacum barrels between science and esoterism: Tommaso Campailla genius loci].

    Science.gov (United States)

    Buscemi, Maria

    2007-01-01

    Tommaso Campailla, as a typical man of his time, had a good humanistic and scientific education. He was born in Modica in 1668 [corrected] from an aristocratic family. When he was sixteen years old he moved to Catania to study law, but in a short time he came back to his native town where he preferred to study as an autodidact. He got married and had children and was elected senator seven times. In spite of his particular look, he was appreciated for his vast culture and his great sensibility. Giovanna Finocchiaro Chimirri noticed his very kind soul and called him: "the christian and Italian Lucretio". In addition, he was a friend of the Arcadian poet Girolama Lorefice Grimaldi. Campailla was a very good medical doctor, although he was an autodidact, and he was very able to inculcate love for medical studies in many students. He fought syphilis rheumatism in a "modern" way, using the "guaiacum barrels" or "vapour stovens" that he had invented. He died in 1740 in Modica.

  14. Accountability, Italian style: how to reply to government pressure?

    Directory of Open Access Journals (Sweden)

    Mauro M

    2015-09-01

    Full Text Available Marianna Mauro, Giovanna TalaricoDepartment of Clinical and Experimental Medicine, Magna Græcia University of Catanzaro, Catanzaro, ItalyAbstract: The current paper addresses the complex issue of accountability by focusing on Italian public hospitals and teaching hospitals; it aims to analyze Italian health care organizations' strategies for responding to the pressure generated by regulations. In particular, in the last few years, Italian hospitals and teaching hospitals have been obliged to implement or improve their accountability instruments in response to a new regulation (known as the Brunetta reform, Legislative Decree number 150/2009. The Legislative Decree aims to measure and assess the results of each public administration unit in terms of efficiency of the human resources, satisfaction level of the final users, and transparency of its action. Despite the initial consensus on the necessity to make the decision process in health care visible and transparent, health care organizations find it difficult to demonstrate accountability. The present paper summarizes the evidence on the degree of compliance to the reform requirements and will allow an in-depth understanding of Italian health organizations' attitudes toward accountability. This study will help policymakers understand the degree of acceptance and application of the new reforms and assess whether the law/regulations may be effective drivers for disseminating a culture of transparency and accountability.Keywords: transparency, Italian health care, law/regulations, compliance

  15. Os Meios de Comunicação e a Figura da Mulher: uma reflexão sobre a personagem Clara da telenovela Em Família

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Baccega

    2016-06-01

    Full Text Available O presente artigo tem por objetivo refletir acerca da construção da figura da mulher operada pelos meios de comunicação, através de um dos seus produtos culturais, a telenovela brasileira. Para tanto, propõe uma investigação que aborda a visibilidade da mulher na mídia, trazendo como arcabouço teórico Baccega (1994; 1999, Escosteguy (2011 e Hall (2013, no que tange aos discursos midiáticos; Lippmann (1966, Bourdieu (2002, Scott (1995, Butler (2015 e Louro (2000 para refletir sobre a figura da mulher. Levando em conta o contexto hegemônico, o presente artigo propõe discutir a ideologia bem como a indústria cultural a fim de analisar, como objeto empírico, a personagem Clara, protagonizada pela atriz Giovanna Antonelli, na telenovela brasileira Em Família, da TV Globo.

  16. Filosofía Criminológica. Dos respuestas críticas al crimen/Criminological philosophy. Two critical responses to crime

    Directory of Open Access Journals (Sweden)

    Mario Antonio Vásquez Cohello

    2017-08-01

    Full Text Available El objetivo de este artículo es presentar una reflexión filosófica sobre el crimen, desde el punto de vista de dos filósofos contemporáneos y vigentes: Jurgen Habermas y Jaques Derrida. Ambos presenciaron con horror el ataque a las Torres Gemelas en la ciudad de New York. Es conocido, por ejemplo, que Habermas se encontraba en los Estados Unidos en el momento del atentado en 2001, y que, como otros ciudadanos en dicho país, no pudo abordar un avión hasta que las autoridades permitiesen despegar vuelos. La realidad de Derrida, sin embargo, no lo excluye, junto a Habermas, de llevar a cabo una reflexión obligada y necesaria desde la filosofía que nos permite repensar nuestra modernidad tomando como punto de referencia un acto terrorífico y monstruoso. Es por ello que Giovanna Borradori, aborda a ambos filósofos que proponen reconsiderar el valor y papel de la comunicación y la necesidad de incluir al otro en la formación de mi identidad. Las intervenciones de ambos filósofos están complementadas por el académico norteamericano Roy Brand y su discurso filosófico sobre el terror, tomando como eje central las propias reflexiones de los dos filósofos arriba mencionados.

  17. Update on critical evidence for use of carnitine analogs in clinical practice in CNS disorders

    Directory of Open Access Journals (Sweden)

    Traina G

    2011-04-01

    Full Text Available Giovanna TrainaDepartment of Economics and Food Sciences, University of Perugia, Perugia, ItalyAbstract: L-carnitine (LC is part of the carnitine shuttle system at the mitochondrial inner membrane (MIM and transports long chain fatty acids over the MIM route. Acetyl-L -carnitine (ALC, the acetyl ester of LC, plays an essential role in intermediary metabolism. To ALC are ascribed neurotrophic actions, antioxidant and antiapoptotic activity, positive effects on mitochondrial metabolism, and stabilization of intracellular membranes. Acylcarnitine and LC supplementation have shown beneficial effects in the treatment of aging, chronic degenerative pathologies and the slowing of the progression of mental deterioration in neurodegenerative diseases, and painful neuropathies. ALC is reported to affect brain energy and phospholipid metabolism and to interact with cell membranes, proteins, and enzymes. It also shows a neuromodulatory effect on synaptic morphology and neurotransmitter synaptic transmission, including that of acetylcholine and dopamine. All these data suggest that ALC can affect several targets in the central nervous system. The roles and effects of LC and ALC have led researchers to investigate carnitine's involvement in a variety of neuropathological states and treatments, including autism, Parkinson's disease, Alzheimer's disease, Down's syndrome, Huntington's disease, cerebellar ataxia, age-associated mental decline, hepatic encephalopathy, and ammonia neurotoxicity. This review summarizes evidence that carnitine analogs play many roles in serious neurological pathologies.Keywords: L-carnitine, acetyl-L-carnitine, brain, neural disorders

  18. Real-time tests of multiple genome alterations take the first steps into the clinic: a learning example

    Directory of Open Access Journals (Sweden)

    Gerratana L

    2016-08-01

    Full Text Available Lorenzo Gerratana,1,2 Giovanna De Maglio,3 Alessandro De Pellegrin,3 Alessandro Follador,1 Karim Rihawi,1,2 Stefano Pizzolitto,3 Fabio Puglisi,1,2 Gianpiero Fasola1 1Department of Oncology, University Hospital of Udine, 2Department of Medical and Biological Sciences, University of Udine, 3Department of Pathology, University Hospital of Udine, Udine, Italy Abstract: Molecular characterization is increasingly changing clinical practice, in both diagnosis and treatment. BRAF is a proto-oncogene that is mutated in ~2%–4% of lung cancers, but the incidence rises to 40%–45% among papillary thyroid cancers. Furthermore, BRAF is a promising target in lung cancer treatment. The present case study covers both the challenges of molecular differential diagnosis and the perspectives opened by targeted therapy by discussing the history of a 78-year-old female affected by a papillary histotype carcinoma with BRAF mutation associated with both thyroid and lung localizations. A differential diagnosis was possible as a consequence of a multidisciplinary approach including an in-depth molecular characterization. Based on this molecular feature, the patient was successfully treated with the BRAF inhibitor dabrafenib after the failure of treatment with standard regimen. To the best of our knowledge, this is the first published case of non-small-cell lung cancer with metastasis to thyroid and with BRAF V600E mutation. Keywords: BRAF mutation, molecular diagnosis, target therapy

  19. El Parque Nacional del Café

    Directory of Open Access Journals (Sweden)

    Ernesto Barrera Duque

    2013-03-01

    Full Text Available Claudia Guevara, gerente de mercadeo, enfrenta la meta de 520.000 visitas para el año 2006, y por este motivo debe presentar un plan comercial para lograr este objetivo. Se presenta información relevante sobre la historia del Parque Nacional del Café (PNC, el producto, mercado, precios, canales y acciones de comercialización, comunicación comercial que permitirá discutir qué estrategias y tácticas emprender para la temporada de diciembre y para el siguiente año de operaciones. Entre los objetivos a lograr está potenciar la diferenciación, aumentar la base de visitantes y atraer turistas extranjeros.

  20. O outro avança sobre mim: dimensões da vida anônima e impessoal na cultura latino-americana

    Directory of Open Access Journals (Sweden)

    Florencia Garramuño

    2016-01-01

    Full Text Available El trabajo explora la hipótesis de que varias transformaciones sobre los modos de concebir la subjetividad, la escritura y la comunidad pueden ser aprehendidos a través de prácticas culturales cada vez más numerosas que registran la transformación de un paisaje social donde los desplazamientos, el nomadismo y la contingencia de las relaciones personales son cada vez más numerosas. Algunas intervenciones radicales en la cultura latinoamericana señalan una deconstrucción de la categoría de persona y exploran formas de lo impersonal o anónimo que insisten en interrogar la intensidad de una experiencia que es irreductible a un yo o un individuo. Se analizan textos y prácticas de Diamela Eltit, Claudia Andújar, Gian Paolo Minelli y Patricio Guzmán.

  1. Multinational Experiment 7. Outcome 3 - Cyber Domain Objective 3.1: Threats and Vulnerability Methodology Version 1.0

    Science.gov (United States)

    2014-02-09

    based on past experience, and if there is one lesson to draw from history it is that  strategic shocks and ruptures in trends are common.  David   Hume ...2 Moteff, John, Claudia Copeland, and John Fischer (2003);  Cornish, Paul,  David  Livingstone, Dave Clemente and Claire Yorke (2011...Moteff, John and Paul Parfomak (2004);  Cornish, Paul,  David  Livingstone, Dave Clemente and Claire Yorke (2011)  UNCLASSIFIED  UNCLASSIFIED  26    down

  2. TEDx Organisers meet at CERN

    CERN Multimedia

    Abha Eli Phoboo

    2013-01-01

    CERN hosted the second TEDx European Organisers meeting last week with around 80 organisers attending from all over Europe. They were given an introduction to CERN and a tour of the LHC experiments.   The participants of the TEDx European Organisers meeting held at CERN last week. Among the attendees was Bruno Giussani, European director of TED, who delivered the welcome address. The TEDx European organisers shared their experiences in workshops and brainstormed about how to work on different aspects of organising a TEDx event, and about improving the relationship between TEDx and TED. “The goal of this meeting was for veteran TEDx organisers to help younger ones, help each other, bring the community together and have better quality events,” said Claudia Marcelloni, head of TEDxCERN. TEDx is an independently organised TED (Technology, Entertainment, Design) talk event, which has grown exponentially all over the world. There are hundreds of TEDx events every day and it n...

  3. Hollywood’s Terror Industry: Idealized beauty and The Bluest Eye

    Directory of Open Access Journals (Sweden)

    E C Koch

    2014-07-01

    Full Text Available Toni Morrison’s novel The Bluest Eye (1970 examines the effects of 1940s American white cultural hegemony on her black characters: Claudia, Pauline, and Pecola. The dominant influence of white society, specifically white ideals of beauty, are perpetuated through film, and exemplified by such actresses as Shirley Temple and Greta Garbo. The terrifying nature of the Hollywood ideal is borne from its influence and ubiquity, and is highlighted by Pecola’s deranged pursuit of this impossible standard of beauty. Ultimately by attempting to realize this paradigm, blacks are disenfranchised while the ideal is recharged with the power of those who continue to pursue it. Keywords:The Bluest Eye, Racial Hegemony, Film Studies, Terror, Ideals of Beauty.

  4. A corporeidad energized Notes on corporeity, territories and current Argentine literature

    Directory of Open Access Journals (Sweden)

    Alejandro Fabián Gasel

    2017-03-01

    Full Text Available The purpose of this paper is to board the relationship among embodiment, territories and the current Argentinean literature. To that end is that a revision, carried out through certain theoretical approaches of some conceptualizations coming from the Merleau-Ponty, Jean-Luc Nancy y Gilles Deleuze philosophy is proposed. The paper is concerned with the validity of the body and literature study, starting by the revision of the usage of the body category in Argentinean literary critic, focusing its interest in Gabriel Giorgi and Claudia Coria. It also attempts to find a relationship between corporeity and territory in current texts such as Fabio Martínez's Los pibes suicidas (2013, Samanta Schweblin's En la estepa, (2010 and La Siberia by Cristina Siscar (2007.

  5. Ethics, design and planning of the built environment

    CERN Document Server

    Moroni, Stefano

    2013-01-01

    The book proposes a set of original contributions in research areas shared by planning theory, architectural research, design and ethical inquiry. The contributors gathered in 2010 at the Ethics of the Built Environment seminar organized by the editors at Delft University of Technology. Both prominent and emerging scholars presented their researches in the areas of aesthetics, technological risks, planning theory and architecture. The scope of the seminar was highlighting shared lines of ethical inquiry among the themes discussed, in order to identify perspectives of innovative interdisciplinary research. After the seminar all seminar participants have elaborated their proposed contributions. Some of the most prominent international authors in the field were subsequently invited to join in with this inquiry. Claudia Basta teaches "Network Infrastructures and Mobility" at Wageningen University. Between 2009 and 2011 she worked as Coordinator of the 3TU Centre of Excellence for Ethics and Technology of Delft Un...

  6. The pedagogy and aesthetic representations of ambience: architecture magazines in the late 20th century in Brazil

    Directory of Open Access Journals (Sweden)

    Rafael Alves Pinto Júnior

    2013-06-01

    Full Text Available La preocupación por mantener a los consumidores bien informados sobre los modelos de buen gusto imperantes ha estado presente en prácticamente todo el periodismo temático, y siguió así de manera inalterable en la “condición” post-moderna de la década de 1980. Para las revistas dedicadas a la arquitectura y dirigidas al público en general - como Casa e Jardim, Casa Claudia y Arquitetura & Construção -, ese fenómeno adquirió peculiaridades de un eclecticismo enciclopédico, a fines del siglo 20 en Brasil. Con esto, lograron mantenerse en el selecto grupo de publicaciones clasificadas como “dictadoras del gusto”, producidas en São Paulo, y que irradiaban para todo el País.

  7. Making of... Construcciones etnográficas de la educación

    OpenAIRE

    Cárcamo Vásquez, Héctor

    2014-01-01

    Cárcamo Vásquez, Héctor (Ed.); Autores: Gloria Mª Abarca Obregón, Paula Escobedo Peiro, Auxiliadora Sales Ciges, Noelia Alcaraz Salarirche, Manuel Fernández Navas, Manuel J. Cotrina García, Judith Arrazola Carballo, Leticia Fraga Colman, Eva Escutia Alatorre, Claudia Francom, Bárbara Gamiño Alvarado, Mayka García García, Fernando Hernández-Hernández, María Domingo Coscollola, Raquel Miño Puigcercós, Sandra Martínez Pérez, Alejandra Montané Lóez, Roxana Hormazábal Fajardo, Emma Qui...

  8. Geschlechtertektonik – Hollywoodkino um 2000 Gender Tectonics in Contemporary Hollywood

    Directory of Open Access Journals (Sweden)

    Sylvia Mieszkowski

    2003-11-01

    Full Text Available Auch im zeitgenössischen Hollywood-Film sind narrative Muster und visuelle Repräsentationen maßgeblich entlang der ‚gender‘-Achse organisiert. In sechs Lektüren untersucht Claudia Liebrand konzeptuelle Verschiebungen und Verwerfungen, die entstehen, wenn sich die Spannung der Geschlechterdifferenz unter dem Druck konfligierender Differenzkonstrukte entlädt.Contemporary Hollywood Cinema organises its narrative patterns and visual representations along an axis that is determined by gender. Liebrand’s readings of six films investigate conceptual displacements and faults which arise when tensions built up by gender difference discharge, sometimes with unexpected results, under the extra pressure of conflicting constructs such as race or sexuality.

  9. Reseñas. Books Review

    Directory of Open Access Journals (Sweden)

    Díaz, Liliana

    2014-10-01

    Full Text Available TORRE, Claudia, El otro desierto de la nación argentina. Antología de narrativa expedicionaria, Bernal, Argentina, Editorial Universidad de Quilmes, 2011, 387 pp. MAURO, Diego y LICHTMAJER, Leandro (compiladores, Los costos de la política. Del Centenario al primer peronismo, Imago Mundi, Buenos Aires, 2014, 130 pp. DE MARCO; Miguel Ángel (h. Ciudad Puerto, Universidad y Desarrollo Regional, Rosario, 1919-1968. CEHDRE, Rosario, 2013, 542 pp. GUARDIA, Sara Beatriz. Primer Congreso Internacional. Las mujeres en los procesos de Independencia de América Latina. Lima, Perú. Sara Beatriz Guardia Edición, CEMHAL, UNESCO, USMP, 2014. 495 pp

  10. Notes on the Dolichenian monument from Pincum/Veliko Gradište

    Directory of Open Access Journals (Sweden)

    Timoc Cãlin

    2016-01-01

    Full Text Available A small inscribed statuette base, found in Pincum (Veliko Gradište, and belonging to the antiquities collector Imre Pongrácz, was rediscovered recently in the deposits of the Banat Museum. This fact put in a new light all that we have known so far about this object, which was thought to be lost. The inscription is dedicated to Dulcenus, a form of the name of the deity Iuppiter Dolichenus, by two standard-bearers of the legio VII Claudia. In the upper part of the stone can be seen traces of the four hooves of an ox and the central quadrangular support by which the animal’s body was sustained. The ex voto can be determined chronologically, by the style of the letters and the form of the message, to the 3rd century AD.

  11. Pictures of the month

    CERN Multimedia

    Claudia Marcelloni de Oliveira

    Starting with this issue, we will publish special pictures illustrating the ongoing construction and commissioning efforts. If you wish to have a professionnal photographer immortalize your detector before it disappears in the heart of ATLAS or for a special event, don't hesitate to contact Claudia Marcelloni de Oliveira (16-3687) from the CERN photo service. Members of the pixel team preparing to insert the outermost layer (the outer of the three barrel pixel layers) into the Global Support Frame for the Pixel Detector in SR1. Ongoing work on the first Big Wheel on the C side. Exploded view of the side-C Big Wheel and the barrel cryostat. The TRT Barrel services (HV, LV, cooling liquid, active gas, flushing gas) are now completely connected and tested. Hats off to Kirill Egorov, Mike Reilly, Ben Legeyt and Godwin Mayers who managed to fit everything within the small clearance margin!

  12. Reconsidering Poe's Readership:A Comparative Study of two translations of The Fall of the House of Usher

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    Aline Evers

    2010-09-01

    Full Text Available This investigation compares two translations from English into Portuguese of Poe’s The Fall of the House of Usher. The corpus comprises a translation/adaptation for young readers, translated by Claudia Ortiz (2005, and a translation for a general audience (i.e. experienced readers, published by Oscar Mendes (1981. We investigate textual aspects such as lexical choices, omissions, and explicitations in order to compare and contrast source and target texts. Guided by this analysis, we discuss the possibility of enlarging Poe’s readership. This discussion is grounded on the Scope Theory (Vermeer and Reiss, 2002 and the Interpretive Community Theory (Fish, 1990. The comparison of the translations indicates that the adaptation seems to respect the intended audience’s reading experiences and to be consistent with social practices, other than translation, which usually take children and youngsters as primary audience.

  13. Padrões de beleza na publicidade das revistas femininas (dos anos 1960 aos dias atuais)

    OpenAIRE

    Gentil, Gisele Mello

    2009-01-01

    Este projeto tem como objetivo pesquisar a influência das revistas femininas na formação do padrão de beleza. Para tanto, parte de uma análise dos padrões de beleza das décadas de 1960, 1970, 1980, 1990 e 2000 veiculados nos anúncios publicitários das revistas CLAUDIA e NOVA, publicadas pela Editora Abril, que constituem o corpus da pesquisa. Destaque especial é dado ao uso de softwares de edição de imagem, como o Photoshop, em virtude da recorrência de seu uso na pós-produção ...

  14. Algunas particularidades socioculturales y lingüísticas del proceso de enseñanza – aprendizaje de ELE a inmigrantes rusohablantes en España

    Directory of Open Access Journals (Sweden)

    Kunetsov, Georgy

    2010-09-01

    Full Text Available El presente artículo basado en la memoria final del Máster en Enseñanza de Español como Lengua Extranjera (UIMP, 2007-2008, tutora Claudia Fernández Silva trata algunos aspectos socioculturales y lingüísticos del alumnado inmigrante procedente de los países de la extinta URSS y las particularidades del proceso enseñanza – aprendizaje que influyen en el trabajo de un profesor de ELE en España. Se da un breve análisis de las principales dificultades morfológicas, sintácticas y otras, al igual que del bagaje sociocultural y emocional del inmigrante rusohablante y el papel del profesor en el proceso de integración.

  15. Entrevista con Yvan Comeau

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    Gloria Leal Leal

    2010-03-01

    Full Text Available Entrevista realizada por Gloria E. Leal Leal, profesora del Departamento de Trabajo Social, a nombre del Comité Editorial. Bogotá, 28 de octubre de 2008. Traducción a cargo de Claudia Mosquera, profesora del Departamento de Trabajo Social de la Universidad Nacional de Colombia. En el marco de la celebración del día de trabajo social, el Departamento de Trabajo Social lo invitó como conferencista del “Seminario de Investigación: la investigación contemporánea de Trabajo Social en Canadá y Quebec” y de la “Conferencia Trabajo Social Colectivo: prácticas y conocimientos. Avances recientes”

  16. Visit of UK firms at CERN

    CERN Multimedia

    FP Department

    2011-01-01

    24 – 25 NOVEMBER 2011 09h00 to 17h00 Thursday 24 November 09h00 to 17h00 Friday 25 November Individual interviews will take place in technicians’ offices. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details which are available from each secretariat of department or from the GS Department web pages at the following URL: http://gs-dep.web.cern.ch/en/content/Industrial-Exhibitions List of Companies: • AWS Electronics • Cryogenic • Hytec Electronics • Industrial Electronic Wiring • M G Sanders • MDC Vacuum • MM Microwave • Premier Building and Engineering • Russel Ductile Castings • Tadley Engineering • NDSL For further information please contact Claudia Bruggmann Furlan GS-IS-LS 73312 or Caroline Laignel GS-DI 73722.

  17. War rape, natality and genocide.

    Science.gov (United States)

    Schott, Robin May

    2011-01-01

    Feminist philosophy can make an important contribution to the field of genocide studies, and issues relating to gender and war are gaining new attention. In this article I trace legal and philosophical analyses of sexual violence against women in war. I analyze the strengths and limitations of the concept of social death—introduced into this field by Claudia Card—for understanding the genocidal features of war rape, and draw on the work of Hannah Arendt to understand the central harm of genocide as an assault on natality. The threat to natality posed by the harms of rape, forced pregnancy and forced maternity lie in the potential expulsion from the public world of certain groups—including women who are victims, members of the 'enemy' group, and children born of forced birth.

  18. Blog y ciberidentidad. El caso de Séptima madrugada (2007

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    Wladimir Chávez Vaca

    2013-05-01

    Full Text Available Séptima Madrugada [Seventh Sunrise], a book written by Claudia Donoso Ulloa, was the first text in Peru which took the leap from cyberspace to the traditional book. The work was printed by publication house Estruendomudo. Despite it being a blog, Ulloa Donoso has insisted that the "main character" represented cannot be identified with herself and that the two personalities have notable differences. At the same time, Ulloa Donoso has also dismissed criticism that her work is an example of "chick lit". The present study evaluates both statements from two theoretical frameworks: Vivian Gornick proposals in "Truth in personal narrative" (2008 and "Women Writers and the Restive Text" (1999 by Barbara Page.

  19. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  20. Ricerca, tutela e valorizzazione del patrimonio archeologico: opinioni a confronto / Research, protection and enhancement of archaeological heritage: comparing different point of views

    Directory of Open Access Journals (Sweden)

    Carmelo Grasso

    2016-12-01

    We publish here the speeches, reviewed by the authors, presented on the 7th of April 2016 at the workshop in honor of Claudia Giontella, dedicated to the social, cultural, political and economic challenges that archeology is called to face in this new century. The first two speeches examine the Italian protection system in the light of some recent innovations: after showing the activity of the “Comando Carabinieri per la Tutela del Patrimonio Culturale”, Carmelo Grasso illustrates the creation in 2015 of a new national task force, operating in situations of natural disasters and wars (“Caschi Blu della Cultura”, while Mario Pagano evaluates the Reform of MiBACT. Then, Paolo Güll discusses theoretical and methodological issues concerning preventive archeology, and Francesca Sogliani focuses on activities that have been promoted to enhance archeological heritage in Basilicata, also in sight of Matera European Cultural Capital 2019.

  1. chromswitch: A flexible method to detect chromatin state switches.

    Science.gov (United States)

    Jessa, Selin; Kleinman, Claudia L

    2018-02-09

    Chromatin state plays a major role in controlling gene expression, and comparative analysis of ChIP-seq data is key to understanding epigenetic regulation. We present chromswitch, an R/Bioconductor package to integrate epigenomic data in a defined window of interest to detect an overall switch in chromatin state. Chromswitch accurately classifies a benchmarking dataset, and when applied genome-wide, the tool successfully detects chromatin changes that result in brain-specific expression. Chromswitch is implemented as an R package available from Bioconductor at https://bioconductor.org/packages/chromswitch. claudia.kleinman@mcgill.ca. Supplementary material are available online. All data and code for the analysis presented in this paper are available at https://doi.org/10.5281/zenodo.1101260.

  2. The coordination office at SIREME 2008 exhibition

    International Nuclear Information System (INIS)

    Grotz, Claudia; Cassin, Fabrice; Evrard, Aurelien; Froeding, Veronique; Galaup, Serge; Kaelble, Laure; Persem, Melanie; Regnier, Yannick; )

    2008-01-01

    The French-German office for Renewable energies (OFAEnR) organised several presentations at the occasion of the SIREME International exhibition of renewable energies and energy management. This document brings together these presentations (slides) dealing with: 1 - The new German Renewable Energy Sources Act (EEG) and its impact on wind energy (Claudia Grotz); 2 - Consequences of the July 10, 2006 wind energy tariff bylaw cancelling (Fabrice Cassin); 3 - Wind energy trajectory in France and Germany: a political perspective (Aurelien Evrard); 4 - The wind energy development areas (Veronique Froeding); 5 - A commitment at the heart of our business: renewable energy sources (Serge Galaup); 6 - The wind energy coordination office (Laure Kaelble); 7 - New challenges of the German wind energy market (Melanie Persem); 8 - An industry - a qualification standard (Yannick Regnier)

  3. Expresividad, creatividad y disfrute como enigma de lo social

    OpenAIRE

    Diego Quattrini

    2015-01-01

    El libro compilado por Graciela Magallanes, Claudia Gandía y Gabriela Vergara conforma una propuesta de análisis teórico y metodológico que vehiculiza la relación entre los procesos de expresividad, creatividad y disfrute con las prácticas marcadas por la estructuración social. El contenido del mismo, logrado a partir de un conjunto de trabajos producidos en el marco de una investigación de más de dos años, da cuenta específicamente de las formas de sensibilidad y la acción colectiva que se d...

  4. CERN inspires 2011 edition of the ARS Electronica Digital Arts Festival

    CERN Multimedia

    Jordan Juras

    2011-01-01

    This year’s annual ARS Electronica Digital Arts Festival featured CERN as the springboard for its theme, ORIGIN – How it All Begins. The prestigious digital arts festival also served as the perfect venue to launch the Collide@CERN project.   Colours and Lights at the ARS Electronica Digital Arts Festival in Linz (Austria). (Photo by Claudia Marcelloni) The CERN cultural policy project, announced at the beginning of 2011 has started to gain momentum. Ariane Koek, art specialist for the Communication Group, received confirmation in May that ARS Electronica had chosen her proposal to use CERN as the primary source of inspiration for their annual ARS Electronica Festival. This marks the first of the cultural policy’s arts partnerships. The world-renowned celebration for the digital arts is held annually in Linz, Austria, where, amongst the incredible collection of displays and productions, the Prix ARS Electronica – the Oscars of the digital arts world -&...

  5. O SUJEITO FEMINISTA PELA NARRADORA DE LYA LUFT

    Directory of Open Access Journals (Sweden)

    Marlene Rodrigues Brandolt

    2015-02-01

    Full Text Available The Lya Luft’s masterpice “O rio do meio” (1996 is discussed through the revealing narrative of the feminist subject transformations and of act’s creation. A perspective of the construction of the self in feminism is drawn, which can be identified by the reader through the narrator’s voice and his relationship with the possible selves. After analyzing several nuances as sumed by self of the narrator, the way how it is told was discussed, in a dialectical relationship, based on Hegel and the reception of Wolfgang Iser and Paul Ricoeur. The problem approach, made by a narrative characterized by the choice of a woman’s view, related to the women's studies critical and linked to Claudia de Lima Costa, Rita Terezinha Schmidt, Vera Queiroz and Maria Célia Detoni, among others.

  6. Transcranial direct current stimulation improves the QT variability index and autonomic cardiac control in healthy subjects older than 60 years

    Directory of Open Access Journals (Sweden)

    Piccirillo G

    2016-11-01

    Full Text Available Gianfranco Piccirillo,1 Cristina Ottaviani,2 Claudia Fiorucci,1 Nicola Petrocchi,2 Federica Moscucci,1 Claudia Di Iorio,1 Fabiola Mastropietri,1 Ilaria Parrotta,1 Matteo Pascucci,1 Damiano Magrì3 1Department of Cardiovascular, Respiratory, Nephrological, Anestesiological and Geriatric Sciences, “Sapienza” University, 2Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, 3Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, Rome, Italy Background: Noninvasive brain stimulation technique is an interesting tool to investigate the causal relation between cortical functioning and autonomic nervous system (ANS responses. Objective: The objective of this report is to evaluate whether anodal transcranial direct current stimulation (tDCS over the temporal cortex influences short-period temporal ventricular repolarization dispersion and cardiovascular ANS control in elderly subjects. Subjects and methods: In 50 healthy subjects (29 subjects younger than 60 years and 21 subjects older than 60 years matched for gender, short-period RR and systolic blood pressure spectral variability, QT variability index (QTVI, and noninvasive hemodynamic data were obtained during anodal tDCS or sham stimulation. Results: In the older group, the QTVI, low-frequency (LF power expressed in normalized units, the ratio between LF and high-frequency (HF power, and systemic peripheral resistances decreased, whereas HF power expressed in normalized units and α HF power increased during the active compared to the sham condition (P<0.05. Conclusion: In healthy subjects older than 60 years, tDCS elicits cardiovascular and autonomic changes. Particularly, it improves temporal ventricular repolarization dispersion, reduces sinus sympathetic activity and systemic peripheral resistance, and increases vagal sinus activity and baroreflex sensitivity. Keywords: transcranial direct current stimulation, QT variability, heart rate variability

  7. Neoadjuvant therapy for locally advanced melanoma: new strategies with targeted therapies

    Directory of Open Access Journals (Sweden)

    La Greca M

    2014-06-01

    Full Text Available Michele La Greca,1 Giuseppe Grasso,2 Giovanna Antonelli,1 Alessia Erika Russo,1 Salvatore Bartolotta,3 Alessandro D’Angelo,1 Felice Vito Vitale,1 Francesco Ferraù1 1Medical Oncology Department, San Vincenzo Hospital, Taormina, Messina, Italy; 2Pathology Department, San Vincenzo Hospital, Taormina, Messina, Italy; 3Surgical Unit, Casa di Cura Gretter-Lucina, Catania, Catania, Italy Abstract: Neoadjuvant chemotherapy has been successfully tested in several bulky solid tumors, but it has not been utilized in advanced cutaneous melanoma, primarily because effective medical treatments for this disease have been lacking. However, with the development of new immunotherapies (monoclonal antibodies specific for cytotoxic T lymphocyte-associated antigen 4 [anti-CTLA-4] and programmed death protein-1 [anti-PD1] and small molecules interfering with intracellular pathways (anti-BRAF and mitogen-activated protein kinase kinase [anti- MEK] the use of this approach is becoming a viable treatment strategy for locally advanced melanoma. The neoadjuvant setting provides a double opportunity for a better knowledge of these drugs: a short-term evaluation of their intrinsic activity, and a deeper analysis of their action and resistance-induction mechanisms. BRAF inhibitors seem to be ideal candidates for the neoadjuvant setting, because of their prompt, repeatedly confirmed response in V600E BRAF-mutant metastatic melanoma. In this report we summarize studies focused on the neoadjuvant use of traditional medical treatments in advanced melanoma and anecdotal cases of this approach with the use of biologic therapies. Moreover, we discuss our experience with neoadjuvant targeted therapy as a priming for radical surgery in a patient with BRAF V600E mutation-positive advanced melanoma. Keywords: neoadjuvant setting, biologic, targeted therapy, vemurafenib, advanced melanoma

  8. Characterization of esterase activity in the Bianchetta trevigiana grape variety under reducing conditions

    Directory of Open Access Journals (Sweden)

    Lomolino G

    2012-10-01

    Full Text Available Giovanna Lomolino, Anna LanteDepartment of Agronomy Food Natural Resources Animals and Environment, Agripolis, Università di Padova Viale dell'Università, Padova, ItalyBackground and methods: While extensive research has been carried out on the enzymes responsible for ester synthesis and hydrolysis by wine strains of Saccharomyces cerevisiae, grape esterase activity is limited. In this study, the autochthonous grape variety, Bianchetta trevigiana, widespread in the Prosecco wine production area of Treviso, Conegliano, and Asolo, Italy, was characterized according to its esterase activity. Because grape skin is very rich in compounds which impart qualitative characteristics to wine, the study of esterase was carried out on this part of the fruit.Results: During enzyme extraction from grape skin, the presence of the reducing agent, β-mercaptoethanol, allowed a better protein yield but reduced esterase activity. Further addition of increasing doses of reducing agents to grape skin protein extract, such as of K2S2O5 (used in winemaking and DTT, reduced or inhibited esterase activity. Even though the zymographic profiles of the extracts obtained with and without β-mercaptoethanol were qualitatively equal, the intensity of enzymatic bands, measured by densitometry, was different.Conclusion: The presence of reducing agents affected the activity of grape skin esterase, and given that this enzyme is involved in the hydrolysis and synthesis of esters, which are important compounds responsible for the flavor of wine, addition of reducing agents could affect the aromatic profile of wine.Keywords: esterase, grape, reducing agent, wine

  9. Water erosion and climate change in a small alpine catchment

    Science.gov (United States)

    Berteni, Francesca; Grossi, Giovanna

    2017-04-01

    WATER EROSION AND CLIMATE CHANGE IN A SMALL ALPINE CATCHMENT Francesca Berteni, Giovanna Grossi A change in the mean and variability of some variables of the climate system is expected to affect the sediment yield of mountainous areas in several ways: for example through soil temperature and precipitation peak intensity change, permafrost thawing, snow- and ice-melt time shifting. Water erosion, sediment transport and yield and the effects of climate change on these physical phenomena are the focus of this work. The study area is a small mountainous basin, the Guerna creek watershed, located in the Central Southern Alps. The sensitivity of sediment yield estimates to a change of condition of the climate system may be investigated through the application of different models, each characterized by its own features and limits. In this preliminary analysis two different empirical mathematical models are considered: RUSLE (Revised Universal Soil Loss Equation; Renard et al., 1991) and EPM (Erosion Potential Method; Gavrilovic, 1988). These models are implemented in a Geographical Information System (GIS) supporting the management of the territorial database used to estimate relevant geomorphological parameters and to create different thematic maps. From one side the geographical and geomorphological information is required (land use, slope and hydrogeological instability, resistance to erosion, lithological characterization and granulometric composition). On the other side the knowledge of the weather-climate parameters (precipitation and temperature data) is fundamental as well to evaluate the intensity and variability of the erosive processes and estimate the sediment yield at the basin outlet. Therefore different climate change scenarios were considered in order to tentatively assess the impact on the water erosion and sediment yield at the small basin scale. Keywords: water erosion, sediment yield, climate change, empirical mathematical models, EPM, RUSLE, GIS

  10. RICKETS AT THE MEDICI COURT OF FLORENCE: THE CASE OF DON FILIPPINO (1577-1582).

    Science.gov (United States)

    Castagna, Maura; Giuffra, Valentina; Fattori, Silvia; Vitiello, Angelica; Caramella, Davide; Giustini, Davide; Fornaciari, Gino

    2014-01-01

    Among the children found in the crypt of the Grand Duke Giangastone in S. Lorenzo Basilica (Florence), the skeletal remains of a 5-year-old child still wearing his fine high social status clothing were recovered. This child of the Medici family was identified as Don Filippino (1577-1582), son of the Grand Duke Francesco I (1541-1587) and Giovanna from Austria (1547 - 1578). The prince showed several pathological deformities of the cranial and post-cranial skeleton, including enlargement of the cranium, thinning of the cranial vault bones (craniotabes), platybasia and marked bending of femora, tibiae and fibulae. Differential diagnosis suggests that Don Filippino was affected by rickets. The occurrence of this metabolic disease related to vitamin D deficiency in a Renaissance high social class individual can be explained by the practice of very prolonged breast-feeding, up until two years of age. Maternal milk contains insufficient vitamin D ratios and retarded weaning severely exposes children to a higher risk of developing rickets, especially if dietary habits are combined with inadequate exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal remains of Don Filippino are compatible with a diagnosis of rickets, caused by the custom of prolonged breast-feeding associated with inadequate sunlight exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal

  11. Effects of combined training vs aerobic training on cognitive functions in COPD: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Aquino G

    2016-04-01

    Full Text Available Giovanna Aquino,1 Enzo Iuliano,1 Alessandra di Cagno,2 Angela Vardaro,3 Giovanni Fiorilli,1 Stefano Moffa,1 Alfonso Di Costanzo,1 Giuseppe De Simone,3 Giuseppe Calcagno1 1Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, 2Department of Health Science, University ForoItalico, Rome, 3“Villa Margherita”, Benevento, Italy Aim: The aim of this study was to investigate the effects of high-intensity aerobic training (AT and high-intensity aerobic training combined with resistance training (ie, combined training [CT] on cognitive function in patients with COPD. Methods: Twenty-eight Caucasian male patients (68.35±9.64 years; mean ± SD with COPD were recruited and randomized into two groups, AT and CT. Both groups performed physical reconditioning for 4 weeks, with a frequency of five training sessions per week. The CT group completed two daily sessions of 30 minutes: one aerobic session and one strength session, respectively; The AT group performed two 30-minute aerobic endurance exercise sessions on treadmill. Physical and cognitive function tests were performed before and after the training intervention performances. Results: Exercise training improved the following cognitive functions: long-term memory, verbal fluency, attentional capacity, apraxia, and reasoning skills (P<0.01. Moreover, the improvements in the CT group were significantly greater than those in the AT group in long-term memory, apraxia, and reasoning skills (P<0.05. Conclusion: CT may be a possible strategy to prevent cognitive decline and associated comorbidities in male patients with COPD. Keywords: physical training, cognition, resistance training, rehabilitation, respiratory disease

  12. Lomi And Totò : An Ethiopian-Italian Colonial or Postcolonial “Love Story”?

    Directory of Open Access Journals (Sweden)

    Giovanna Trento

    2007-01-01

    Full Text Available Lomi and Totò. An Ethiopian-Italian Colonial or Postcolonial “Love Story”? introduces various and still open questions related to the current necessity of a deeper study of the Italian colonial presence in the African Horn. The source of this article is the relationship between Lomi and Totò, an Ethiopian woman and an Italian man who are not alive anymore, as it is seen and told by their five children (with some additional illuminating interviews. This story started during the Italian colonial fascist period, continued in the Fifties and Sixties in postcolonial East Africa, ended up in Italy in the Eighties, and is still alive in the memory of Lomi and Totò descendents. This “love story” has different shades and can be read from several points of view: personal, sentimental, familiar, social, anthropological, and historical. For some aspects it is unique, but for others it is exemplary of its time and allows us to look into important dynamics during wide and complex periods. Giovanna Trento in this article, thanks to the observation of this “private history”, highlights a certain controversial and unstable degree of fluidity between colonial and postcolonial periods, also questioning the degree of freedom individuals might have within a given social framework, thus suggesting some crucial and sometimes ambiguous issues related to: the use of racial laws in the fascist period; notions of concubinage, marriage and citizenship; gender and power relations; subaltern conditions and marginality within Italian colonialism; discrepancies between portraying African women and relating to them; new African-Italian identities; building collective memory and family storytelling; reproducing, suffering, or overcoming the “colony” today.

  13. Daphnia magna and Xenopus laevis as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625

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    Galdiero E

    2017-04-01

    Full Text Available Emilia Galdiero,1 Annarita Falanga,2 Antonietta Siciliano,1 Valeria Maselli,1 Marco Guida,1 Rosa Carotenuto,1 Margherita Tussellino,1 Lucia Lombardi,3 Giovanna Benvenuto,4 Stefania Galdiero2 1Department of Biology, 2Department of Pharmacy and CiRPEB, University of Naples Federico II, 3Department of Experimental Medicine, Second University of Naples, 4Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy Abstract: The use of quantum dots (QDs for nanomedicine is hampered by their potential toxicologic effects and difficulties with delivery into the cell interior. We accomplished an in vivo study exploiting Daphnia magna and Xenopus laevis to evaluate both toxicity and uptake of QDs coated with the membranotropic peptide gH625 derived from the glycoprotein H of herpes simplex virus and widely used for drug delivery studies. We evaluated and compared the effects of QDs and gH625-QDs on the survival, uptake, induction of several responsive pathways and genotoxicity in D. magna, and we found that QDs coating plays a key role. Moreover, studies on X. laevis embryos allowed to better understand their cell/tissue localization and delivery efficacy. X. laevis embryos raised in Frog Embryo Teratogenesis Assay-Xenopus containing QDs or gH625-QDs showed that both nanoparticles localized in the gills, lung and intestine, but they showed different distributions, indicating that the uptake of gH625-QDs was enhanced; the functionalized QDs had a significantly lower toxic effect on embryos’ survival and phenotypes. We observed that D. magna and X. laevis are useful in vivo models for toxicity and drug delivery studies. Keywords: membranotropic peptide, delivery, blood–brain barrier, nanoparticles, genotoxicity

  14. Bedside teaching and the acquisition of practical skills in mid-sixteenth-century Padua.

    Science.gov (United States)

    Stolberg, Michael

    2014-10-01

    Very little is known to this point about the practical skills which sixteenth-century physicians needed and applied at the bedside and even less about how these skills were taught to students. Drawing on student notebooks and on printed collections of consilia by Padua professors, this paper outlines the different settings in which case-centered and, more specifically, bedside teaching was imparted in mid-sixteenth-century Padua. It describes the range of diagnostic and therapeutic skills that students acquired thanks to this hands-on training at the patient's bedside, from uroscopy and feeling the pulse to the manual exploration of the patient's abdomen, which, historians have wrongly believed, physicians performed very rarely or not at all, and surgical skills. Taking a closer look, more specifically, at the role of teaching in the Hospital of San Francesco in Padua, the paper provides evidence that not only Giovanna Battista da Monte but also at least one other mid-sixteenth-century professor, Antonio Fracanzani, made systematic use of the teaching opportunities which the hospital offered. Ultimately, the paper will argue that clinical teaching in the hospital did not differ fundamentally from forms of bedside teaching in the patients' homes, however. Both became increasingly popular in Padua and elsewhere at the time, reflecting a growing appreciation for the practical and sensory skills which future physicians needed in addition to theoretical learning if they hoped to be successful in the highly contested early modern medical marketplace. © The Author 2013. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. PREFACE: Emerging non-volatile memories: magnetic and resistive technologies Emerging non-volatile memories: magnetic and resistive technologies

    Science.gov (United States)

    Dieny, B.; Jagadish, Chennupati

    2013-02-01

    Giovanna Lani and Mr Colin Adcock, Publishing Editors of the journal, for their help with this cluster issue.

  16. Galáxia forma mosaico digital com artistas e teóricos das novas mí­dias

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    Mirna Feitoza Pereira

    2008-11-01

    Full Text Available Em que medida a artemí­dia da América Latina é diferente da produzida no primeiro mundo? É necessário ter alta tecnologia para fazer artemí­dia? Qual é a ética que subjaz a estética dessa arte emergente? Estes são alguns aspectos contemplados nesta entrevista realizada com artistas e pesquisadores que exploram as relações da arte com a tecnologia e a ciência em diferentes paí­ses do mundo, entre eles, Claudia Gianetti (Mecad/Espanha, Monika Fleischmann (Mars/Alemanha, Silvia Laurentiz (PUC-SP/Brasil, Shuddhabrata Sengupta (Sarai/Ándia e Eduardo Kac (The School of the Art Institute of Chicago. Eles falaram com Galáxia nos intervalos de suas apresentações em dois importantes eventos internacionais de artemí­dia realizados em São Paulo em 2002, o File (Festival Internacional de Linguagem Eletrônica e o Emoção Art.ficial. Palavras-chave novas mí­dias, cibercultura, arte, ciência, tecnologia Abstract At what extent is media art in Latin America different from the one made in the First World? Is it necessary to have high technology to make media art? What are the ethics underneath the esthetics of this emerging form of art? These are some of the aspects contemplated in this interview made with artists and researchers that explore the connections between art, technology and science in different countries around the world. Some of them are: Claudia Gianetti (Mecad/Spain, Monika Fleischmann (Mars/ Germany, Silvia Laurentiz (PUC-SP/Brazil, Shuddhabrata Sengupta (Sarai/India and Eduardo Kac (The School of the Art Institute of Chicago. They have spoken to Galáxia during the breaks of their presentations in two important international events about media art which took place in the city of São Paulo last year, File (Electronic Language International Festival and Emoção Art.ficial. Key words new media, cyberculture, art, science, technology

  17. New strategies to ensure good patient–physician communication when treating adolescents and young adults with cancer: the proposed model of the Milan Youth Project

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    Magni MC

    2015-08-01

    Full Text Available Maria Chiara Magni,1 Laura Veneroni,1 Carlo Alfredo Clerici,2 Tullio Proserpio,3 Giovanna Sironi,1 Michela Casanova,1 Stefano Chiaravalli,1 Maura Massimino,1 Andrea Ferrari1 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; 2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 3Pastoral Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Abstract: Adolescence is a particularly complex time of life, entailing physiological, psychological, and social changes that further the individual's cognitive, emotional, and social growth. Being diagnosed with cancer at this time can have important consequences on an individual's emotional and physical development, and adolescent and young adult cancer patients have particular medical and psychosocial needs. Patient–physician communications are important in any clinical relationship, but fundamental in the oncological sphere because their quality can affect the patient–physician relationship, the therapeutic alliance, and patient compliance. A major challenge when dealing with adolescent and young adult patients lies in striking the right balance between their need and right to understand their disease, treatment, and prognosis, and the need for them to remain hopeful and to protect their emotional sensitivity. We herein describe the activities of the Youth Project of the Istituto Nazionale Tumori in Milan, Italy in order to share a possible model of interaction with these special patients and the tactics our group has identified to help them communicate and share their thoughts. This model implies not only the involvement of a multidisciplinary team, including psychologists and spirituality experts, but also the constitution of dedicated creative activities to give patients the opportunity to express feelings they would otherwise never feel at ease putting into words. These efforts seek the goal to minimize the potentially

  18. Proceedings of the 20th ASPA Congress, Bologna, June 11-13, 2013

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    Guest Editors: A. Piva, P. Bosi, A. Bonaldo, F. Sirri, A. Badiani, G. Biagi, R. Davoli, G. Martelli, A. Meluzzi, P. Trevisi

    2013-06-01

    Full Text Available The 20th Congress of the Animal Science and Production Association (ASPA, is held in the prestigious home of the oldest university of the world: Bologna. The anniversary also celebrates the 40th year of the founding of the Society and is an occasion to remember the past and plan for the future of Animal Sciences in Italy. In this Congress, 137 oral presentations and 155 posters are presented, for a total of 292 scientific contributions. The Congress sessions with their relative number of papers are listed as follows: Animal breeding and genetics 109, Nutrition and feeding 45, Dairy production 42, Animal welfare, health and behaviour 39, Meat quality 35, Poultry and rabbit production 11 and Aquaculture 11. I would like to point out that 3 main lectures will be presented in the Animal breeding and genetics, Nutrition and feeding and Animal welfare, health and behaviour sessions, respectively. I would thank, first of all, Prof. Vincenzo Russo, Honorary President of the Congress and Emeritus of ASPA, for the contribution of the University of Bologna in organizing this event. I would also thank all the members of the Scientific Committee, Prof. Andrea Piva (Chairperson, Prof. Anna Badiani, Prof. Giacomo Biagi, Dr. Alessio Bonaldo, Prof. Paolo Bosi, Prof. Roberta Davoli, Prof. Luca Fontanesi, Prof. Giovanna Martelli, Prof. Adele Meluzzi, Dr. Attilio Mordenti, Prof. Luca Sardi, Dr. Federico Sirri, Dr. Paolo Trevisi, and of the Organizing Committee, Prof. Claudio Cavani (Chairperson, Prof. Stefania Dall’Olio, Prof. Andrea Formigoni, Prof. Pier Giorgio Monetti, Prof. Leonardo Nanni Costa, Dr. Massimiliano Petracci, Prof. Giuliano Zaghini, Dr. Paolo Zambonelli. A special thanks to the secretary of the Congress, MV Congressi. Indeed, I would like to congratulate and thank all those who have organized the meeting and have collaborated in reviewing the summaries for what they have done for ASPA and the Italian Animal Science. A special thanks to Prof

  19. Hollow viscus injuries: predictors of outcome and role of diagnostic delay

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    Mingoli A

    2017-08-01

    Full Text Available Andrea Mingoli,1,2 Marco La Torre,1,2 Gioia Brachini,1,2 Gianluca Costa,3 Genoveffa Balducci,3 Barbara Frezza,3 Giovanna Sgarzini,4 Bruno Cirillo1,2 1Emergency Department, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy; 2Department of Surgery P Valdoni, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy; 3Surgical Department of Clinical Sciences, Biomedical Technologies and Translational Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 4Department of Surgery, S Giovanni Addolorata Hospital, Rome, Italy Introduction: Hollow viscus injuries (HVIs are uncommon but potentially catastrophic condi­tions with high mortality and morbidity rates. The aim of this study was to analyze our 16-year experience with patients undergoing surgery for blunt or penetrating bowel trauma to identify prognostic factors with particular attention to the influence of diagnostic delay on outcome. Methods: From our multicenter trauma registry, we selected 169 consecutive patients with an HVI, enrolled from 2000 to 2016. Preoperative, intraoperative, and postoperative data were analyzed to assess determinants of mortality, morbidity, and length of stay by univariate and multivariate analysis models. Results: Overall mortality and morbidity rates were 15.9% and 36.1%, respectively. The mean length of hospital stay was 23±7 days. Morbidity was independently related to an increase of white blood cells (P=0.01, and to delay of treatment >6 hours (P=0.033, while Injury Severity Score (ISS (P=0.01, presence of shock (P=0.01, and a low diastolic arterial pressure registered at emergency room admission (P=0.02 significantly affected postoperative mortality. Conclusion: There is evidence that patients with clinical signs of shock, low diastolic pressure at admission, and high ISS are at increased risk of postoperative mortality. Leukocytosis and delayed treatment (>6 hours were independent predictors of postoperative

  20. Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo®

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    Paolo Solla

    2010-08-01

    Full Text Available Paolo Solla, Antonino Cannas, Francesco Marrosu, Maria Giovanna MarrosuMovement Disorders Center, Institute of Neurology, University of Cagliari, Cagliari, ItalyAbstract: Parkinson disease (PD is a neurodegenerative disorder characterized by 3 cardinal motor symptoms: resting tremor, rigidity, and bradykinesia. Since its introduction 40 years ago, levodopa has represented the gold standard for dopaminergic stimulation therapy in patients with PD. Levodopa is routinely combined with a dopa-decarboxylase inhibitor (DDCI to prevent the conversion of levodopa into dopamine in peripheral circulation. However, up to 80% of patients treated with continuous levodopa manifest the onset of disabling motor complications capable of producing an adverse effect on quality of life as the disease progresses. In recent years, a new, safe, and efficacious armamentarium of treatment options has been provided by the marketing of the catechol-O-methyltransferase (COMT inhibitor, entacapone, a peripheral blocker of dopa to 3-0-methyldopa metabolism, which increments levodopa brain availability. When administered with levodopa, entacapone conjugates the rapid onset of levodopa-induced effects with a protracted efficiency, thus providing additional benefits to classic levodopa treatment by increasing “on” time in fluctuating PD patients, and theoretically providing a more continuous and physiological-like stimulation of dopamine receptors implying a reduced risk of motor complications. In this context, the use of a single administration of combined ­carbidopa/levodopa/entacapone (Stalevo® in the treatment of PD affords clinical improvements similar to those obtained by 2 separate tablets (ie, levodopa/DDCI and entacapone, although the former produces a more positive effect on quality of life than the latter. Additionally, the STalevo Reduction In Dyskinesia Evaluation (STRIDE-PD study was designed with the aim of demonstrating that the combination of levodopa

  1. Left ventricular structure and remodeling in patients with COPD

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    Pelà G

    2016-05-01

    Full Text Available Giovanna Pelà,1 Mauro Li Calzi,1 Silvana Pinelli,1 Roberta Andreoli,1 Nicola Sverzellati,2 Giuseppina Bertorelli,1 Matteo Goldoni,1 Alfredo Chetta11Department of Clinical and Experimental Medicine, 2Department of Surgery, University Medical School, University Hospital Parma, Parma, ItalyBackground: Data on cardiac alterations such as left ventricular (LV hypertrophy, diastolic dysfunction, and lower stroke volume in patients with COPD are discordant. In this study, we investigated whether early structural and functional cardiac changes occur in patients with COPD devoid of manifest cardiovascular disease, and we assessed their associations with clinical and functional features.Methods: Forty-nine patients with COPD belonging to all Global Initiative for Chronic Obstructive Lung Disease (GOLD classes were enrolled and compared with 36 controls. All subjects underwent clinical history assessment, lung function testing, blood pressure measurement, electrocardiography, and conventional and Doppler tissue echocardiography. Patients were also subjected to computed tomography to quantify emphysema score.Results: Patients with COPD had lower LV cavity associated with a marked increase in relative wall thickness (RWT, suggesting concentric remodeling without significant changes in LV mass. RWT was significantly associated with ratio of the forced expiratory volume in 1 second to the forced vital capacity and emphysema score and was the only cardiac parameter that – after multivariate analysis – significantly correlated with COPD conditions in all individuals. Receiver operating characteristic curve analysis showed that RWT (with a cutoff point of 0.42 predicted the severity of COPD with 83% specificity and 56% sensitivity (area under the curve =0.69, 95% confidence interval =0.59–0.81. Patients with COPD showed right ventricular to be functional but no structural changes.Conclusion: Patients with COPD without evident cardiovascular disease

  2. Profile of PEGylated interferon beta in the treatment of relapsing-remitting multiple sclerosis

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    Cocco E

    2015-05-01

    Full Text Available Eleonora Cocco, Maria Giovanna Marrosu Multiple Sclerosis Center, Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy Abstract: Several treatments are currently available for relapsing-remitting multiple sclerosis. Among them, interferon (IFN beta remains a valid treatment approach because of its good benefit/risk profile. Due to the need for frequent administration (weekly, at a minimum, the use of IFN beta is limited by uncomfortable side effects that could reduce adherence to and persistence with the treatment. The use of subcutaneous polyethylene glycol (PEGylated interferon beta-1a (PEG-IFN has been proposed to offer a better combination of pharmacokinetic and pharmacodynamic profiles and therapy-related side effects. A 125 µg dose of PEG-IFN given every 2 or 4 weeks was tested in two Phase I studies and shown to be as safe and efficient as IFN beta-1a but with a longer half-life. A Phase III trial (ADVANCE comparing 125 µg of PEG-IFN given every 2 or 4 weeks with placebo in 1,512 patients with relapsing-remitting multiple sclerosis showed significant reductions in both the annualized relapse rate (ARR and the occurrence of new or newly enlarged T2 brain lesions in both experimental groups versus placebo after the first year. Moreover, 38% fewer patients showed progression of disability (P=0.04 in the PEG-IFN groups. During the second year, the ARR was further reduced in the PEG-IFN 2-week treatment group (0.230 at 1 year versus 0.178 at 2 years and was maintained in the 4-week treatment group. Patients who received immediate PEG-IFN treatment showed improved clinical efficacy (ARR, risk of relapse, 12-week disability progression and magnetic resonance imaging parameters (new T2 and newly enlarging lesions, gadolinium-positive lesions compared with those with delayed treatment. The effects were more evident with the 2-week dose for all endpoints considered. Furthermore, PEG-IFN was

  3. Generation of RNA in abiotic conditions.

    Science.gov (United States)

    di Mauro, Ernesto

    . Ciciriello, S. Pino, G. Costanzo, E. Di Mauro. From formamide to RNA: the roles of formamide and water in the evolution of chemical information. Research In Microbiology, Special Issue on The Origin of life and Microbiology (2009) 160:441-448. (2) Costanzo, G., Saladino, R., Crestini, C., Ciciriello, F., and Di Mauro, E. Nucleoside phos-phorylation by phosphate minerals. J. Biol. Chem. (2007) 282: 16729-16735. (3) Samanta Pino, Fabiana Ciciriello, Giovanna Costanzo and E. Di Mauro, Nonenzymatic RNA Ligation in Water J. Biol. Chem. (2008), 283: 36494-36503 (4) Costanzo, G., Pino, S., Ciciriello, F., and Di Mauro, E. Generation of long RNA chains in water. J Biol Chem. (2009) 284:33206-33216.

  4. 454 next generation-sequencing outperforms allele-specific PCR, Sanger sequencing, and pyrosequencing for routine KRAS mutation analysis of formalin-fixed, paraffin-embedded samples

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    Altimari A

    2013-08-01

    Full Text Available Annalisa Altimari,1,* Dario de Biase,2,* Giovanna De Maglio,3 Elisa Gruppioni,1 Elisa Capizzi,1 Alessio Degiovanni,1 Antonia D'Errico,1 Annalisa Pession,2 Stefano Pizzolitto,3 Michelangelo Fiorentino,1,# Giovanni Tallini2,#1Laboratory of Molecular Oncologic and Transplantation Pathology, S. Orsola-Malpighi Hospital, Bologna, 2Laboratory of Molecular Pathology, Anatomic Pathology, Bellaria Hospital, Bologna, 3Department of Pathology, S. Maria della Misericordia Hospital, Udine, Italy*These authors contributed equally to this work #These authors share senior authorshipAbstract: Detection of KRAS mutations in archival pathology samples is critical for therapeutic appropriateness of anti-EGFR monoclonal antibodies in colorectal cancer. We compared the sensitivity, specificity, and accuracy of Sanger sequencing, ARMS-Scorpion (TheraScreen® real-time polymerase chain reaction (PCR, pyrosequencing, chip array hybridization, and 454 next-generation sequencing to assess KRAS codon 12 and 13 mutations in 60 nonconsecutive selected cases of colorectal cancer. Twenty of the 60 cases were detected as wild-type KRAS by all methods with 100% specificity. Among the 40 mutated cases, 13 were discrepant with at least one method. The sensitivity was 85%, 90%, 93%, and 92%, and the accuracy was 90%, 93%, 95%, and 95% for Sanger sequencing, TheraScreen real-time PCR, pyrosequencing, and chip array hybridization, respectively. The main limitation of Sanger sequencing was its low analytical sensitivity, whereas TheraScreen real-time PCR, pyrosequencing, and chip array hybridization showed higher sensitivity but suffered from the limitations of predesigned assays. Concordance between the methods was k = 0.79 for Sanger sequencing and k > 0.85 for the other techniques. Tumor cell enrichment correlated significantly with the abundance of KRAS-mutated deoxyribonucleic acid (DNA, evaluated as ΔCt for TheraScreen real-time PCR (P = 0.03, percentage of mutation for

  5. Bevacizumab in the treatment of NSCLC: patient selection and perspectives

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    Russo AE

    2017-12-01

    Full Text Available Alessia E Russo,1 Domenico Priolo,1 Giovanna Antonelli,1 Massimo Libra,2 James A McCubrey,3 Francesco Ferraù1 1Medical Oncology Department, San Vincenzo Hospital, Taormina (Messina, Italy; 2Laboratory of Translational Oncology & Functional Genomics, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; 3Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA Abstract: Non-small-cell lung cancer (NSCLC represents about 85% of all lung cancers, and more than half of NSCLCs are diagnosed at an advanced stage. Chemotherapy has reached a plateau in the overall survival curve of about 10 months. Therefore, in last decade novel targeted approaches have been developed to extend survival of these patients, including antiangiogenic treatment. Vascular endothelial growth factor (VEGF signaling pathway plays a dominant role in stimulating angiogenesis, which is the main process promoting tumor growth and metastasis. Bevacizumab (bev; Avastin® is a recombinant humanized monoclonal antibody that neutralizes VEGF’s biologic activity through a steric blocking of its binding with VEGF receptor. Currently, bev is the only antiangiogenic agent approved for the first-line treatment of advanced or recurrent nonsquamous NSCLC in “bev-eligible” patients. The ineligibility to receive bev is related to its toxicity. In the pivotal trials of bev in NSCLC, fatal bleeding events including pulmonary hemorrhage were observed with rates higher in the chemotherapy-plus-bev group. Therefore, in order to reduce the incidence of severe pulmonary hemorrhage, numerous exclusion criteria have been characteristically applied for bev such as central tumor localization or tumor cavitation, use of anticoagulant therapy, presence of brain metastases, age of patients (elderly. Subsequent studies designed to evaluate the safety of bev have demonstrated that this agent is safe and

  6. Illness denial questionnaire for patients and caregivers

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    Rossi Ferrario S

    2017-03-01

    Full Text Available Silvia Rossi Ferrario,1 Ines Giorgi,2 Paola Baiardi,3 Laura Giuntoli,4 Gianluigi Balestroni,1 Paola Cerutti,1 Marina Manera,2 Paola Gabanelli,2 Valentina Solara,5 Roberta Fornara,6 Michela Luisetti,1 Pierangela Omarini,1 Giovanna Omarini,1 Giulio Vidotto4 1Psychology Unit, Istituti Clinici Scientifici Maugeri SpA SB, Veruno, NO, Italy; 2Psychology Unit, 3Scientific Direction, Istituti Clinici Scientifici Maugeri SpA SB, Pavia, Italy; 4Department of General Psychology, University of Padova, Padova, Italy; 5Department of Neurology, ALS Centre, “Maggiore della Carita`” University Hospital, Novara, Italy; 6Psychology Unit, SS Trinità Hospital, Borgomanero, NO, Italy Purpose: Interest in assessing denial is still present, despite the criticisms concerning its definition and measurement. We tried to develop a questionnaire (Illness Denial Questionnaire, IDQ assessing patients’ and caregivers’ denial in relation to their illness/disturbance. Patients and methods: After a preliminary study, a final version of 24 dichotomous items (true/false was selected. We hypothesized a theoretical model with three dimensions: denial of negative emotions, resistance to change, and conscious avoidance, the first two composing the actual Denial and the last representing an independent component of the illness denial behavior. The IDQ was administered to 400 subjects (219 patients and 181 caregivers together with the Anxiety–Depression Questionnaire – Reduced form (AD-R, in order to assess concurrent validity. Confirmatory factor analysis (CFA, internal consistency indices (Cronbach’s α and McDonald’s ω, and test–retest analysis were performed. Results: CFA and internal consistency indices (Cronbach’s α: 0.87–0.96 indicated a clear and meaningful three-factor structure of IDQ, for both patients and caregivers. Further analyses showed good concurrent validity, with Denial and its subscale negatively associated with anxiety and depression and

  7. Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases

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    Iudici M

    2017-02-01

    Full Text Available Michele Iudici, Rosaria Irace, Antonella Riccardi, Giovanna Cuomo, Serena Vettori, Gabriele Valentini Rheumatology Section, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy Introduction/objectives: To prospectively assess the quality of life (QoL of patients affected by undifferentiated connective tissue diseases (UCTDs and to identify factors associated with changes over time.Patients and methods: A total of 46 consecutive UCTD patients completed the Short-Form 36 (SF-36 questionnaire at presentation and then yearly. At each 6-month visit, all patients underwent a detailed history taking and a laboratory and physical assessment, in order to follow the evolution of the disease over time and to assess the the co-existence of fibromyalgia.Results: At presentation, scores lower than the average of the general population were detected in 34 (74% and 41 (89% patients in the physical and mental domains, respectively. No difference between patients with and without Raynaud’s phenomenon was detected. Fibromyalgia was the only independent variable associated with an impaired physical component summary score (p = 0.0009. No patient feature was found to be associated with the basal mental component summary score. During 24 months of follow-up, a significant improvement (ie, a change ≥5 from baseline in physical component summary and mental component summary scores was observed in 14 (33.3% and 20 (43.4% patients, respectively. Patients who significantly improved in the physical domain more frequently had a history of glucocorticoids intake (p < 0.001, while those who improved in the mental component more frequently had a history of either glucocorticoids (p = 0.043 or immunosuppressors (p = 0.037 intake during follow-up.Conclusion: UCTD patients perceive a worse QoL, regardless of Raynaud’s phenomenon Fibromyalgia is one of the major contributors of physical QoL, whereas no factor influencing

  8. [Challenges in the context of medical care during a naval research expedition. A case report].

    Science.gov (United States)

    Schröter, C; Schwarz-Schampera, U; Mommsen, P; Krettek, C

    2014-05-01

    Exploration for natural resources in the seabed of the Indian Ocean was undertaken by the German government institution of earth sciences and resources ("Bundesanstalt für Geowissenschaften und Rohstoffe", BGR) in November 2012. To provide for the medical safety of crew and scientists, a cooperation between the BGR and the trauma department of the Hannover Medical School was established. Research by physicians accompanying the naval expedition revealed that medical consultations mainly occur because of respiratory infections, abdominal discomfort, genitourinary discomfort and seasickness, with the rate of traumas being between 31% and 41%. Di Giovanna et al. stated that 97% of all emergencies on cruise ships are not critical and only 3% need an immediate emergency medical intervention. Consultations were already performed on the mainland prior to departure and included minor traumas due to non-appropriate footwear, otitis and respiratory infections. Seasickness was the main reason for consultation during the first days at sea. Strong seas resulted in some bruises. Minor injuries and foreign body injuries to the hands and feet also required consultation. First-degree sunburns resulted from exposure to the sun, while air-conditioning caused rhinosinusitis and conjunctivitis. A special consultation was a buccal splitting of tooth 36. An immediate emergency medical intervention was not necessary due to the relative low level of pain for the patient; however, due to the risk of further damage caused by nocturnal bruxism, a protective splint was formed using a small syringe. Other reasons for consultation were similar to those reported in the general literature. Medical activities at exotic locations may create the vision of a holiday character at first; however, intensive planning and preparation are needed. We recommend contacting police, customs, the federal institute for drugs and medical devices as well as the labour inspectorate, preferably in both the originating

  9. Electricity and the Technology–Skill Complementarity: Evidence from the Swedish Industrial Census of 1931

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    Svante Prado

    2017-04-01

    Full Text Available Notwithstanding the popularity among economists of attributing the surging inequality of recent decades to technology–skill complementarity, researchers with a keen eye on history have been reluctant to pick up this thread. This paper joins Claudia Goldin and Lawrence Katz’s attempt to examine the role of electrification as an example of a technology that is complementary to workers’ rising skill levels. Sweden electrified manufacturing processes rapidly in the first quarter of the twentieth century, while the supply of skills through secondary education only increased significantly in the 1950s. We use industry-specific information from the Swedish Industrial Census of 1931 to establish whether electricity and the use of white-collar workers correlated positively. The results indicate that the correlation was positive, but the estimated effect was rather small. Moreover, the available evidence for skill ratios does not suggest that inequality, thus measured, increased. We conclude that labor market institutions prevented—and also overturned—the inequality push emanating from technology.

  10. Historical evolution of the concept of anorexia nervosa and relationships with orthorexia nervosa, autism, and obsessive-compulsive spectrum

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    Dell'Osso L

    2016-07-01

    Full Text Available Liliana Dell’Osso,1 Marianna Abelli,1 Barbara Carpita,1 Stefano Pini,1 Giovanni Castellini,2 Claudia Carmassi,1 Valdo Ricca2 1Psychiatry Section, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 2Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA, University of Florence, Florence, Italy Abstract: Eating disorders have been defined as “characterized by persistence disturbance of eating or eating-related behavior that results in the altered consumption or absorption of food and that significantly impairs health or psychosocial functioning”. The psychopathology of eating disorders changed across time under the influence of environmental factors, determining the emergence of new phenotypes. Some of these conditions are still under investigation and are not clearly identified as independent diagnostic entities. In this review, the historic evolution of the eating disorder concept up to the recent Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, has been evaluated. We also examined literature supporting the inclusion of new emergent eating behaviors within the eating disorder spectrum, and their relationship with anorexia, autism, and obsessive–compulsive disorder. In particular, we focused on what is known about the symptoms, epidemiology, assessment, and diagnostic boundaries of a new problematic eating pattern called orthorexia nervosa that could be accepted as a new psychological syndrome, as emphasized by an increasing number of scientific articles in the last few years. Keywords: anorexia nervosa, autism spectrum disorders, eating disorders spectrum, obsessive–compulsive spectrum, orthorexia nervosa, DSM-5

  11. Soldados astures en las legiones romanas

    Directory of Open Access Journals (Sweden)

    Narciso Vicente Santos Yanguas

    2003-01-01

    Full Text Available Los astures tomarían parte en el ejército romano primero como tropas auxiliares (época de Augusto y dinastía julio-claudia y a continuación como legionarios (dinastías de los Flavios y Antoninos. Esta gradación temporal se corresponde con las diversas fases del proceso de asimilación de las formas de vida romana por parte de las comunidades indígenas. La promoción social constituiría uno de los privilegios derivados de su participación en la milicia, tal vez más acusada en el caso de las tropas auxiliares.The Asturian troops in the roman army were in origin auxiliary troops (during the Augustuan and Julian-Claudian ages and later on regular legionary troops (during the Flavian and Antoninian ages. This temporal gradation runs parallel to the process of assimilation of roman life by native communities. Social promotion would become a privilege directly derived from the enrolment in the army, this being a more visible fact perhaps in the case of the auxiliary troops.

  12. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Switzerland (please sp...

  13. TECHNICAL TRAINING SEMINAR: National Instruments

    CERN Multimedia

    Monique Duval

    2004-01-01

    From 9:30 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Data acquisition systems on PCs, industrial measurement and control techniques, advanced LabVIEW software and PXI instrumentation, and system components for tests and automation will be presented. Walk-in courses will address DIAdem, LabVIEW and data acquisition. Language: English and French Free seminars and courses, no registration Organisers: Rolf Stampfli / IT-CO / 78102 & 160367 / Rolf.Stampfli@cern.ch Davide Vitè / HR-PMD-ATT / 75141 Davide.Vite@cern.ch For more information and the complete event programme, please visit the...

  14. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrates unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) 10:30 -...

  15. Technical Training: Technical Training Seminar

    CERN Multimedia

    2004-01-01

    Tuesday 30 March TECHNICAL TRAINING SEMINAR From 9:00 to 12:00 and from 13:00 to 16:00 hrs - Council Chamber, Salle B, Salle des Pas Perdus National Instruments (NI) on Tour 2004 Claudia Jüngel, Evrem Yarkin, Joel Clerc, Hervé Baour / NATIONAL INSTRUMENTS The special event NI on Tour 2004, run in Germany, Austria and Switzerland, will be at CERN on March 30. Technical seminars and free introductory courses will be offered all day long in the Council Chamber, Salle B, and Salle des Pas Perdus (buildings 61 and 503). Technical conferences: 09:00 - 12:00 Data acquisition systems on PCs. Industrial measurement and control techniques. 13:00 - 16:00 Advanced LabVIEW software and PXI instrumentation. Measuring instruments and system components for teststand automation. Introductory courses: 09:00 - 12:00 DIAdem: Data analysis and presentation 13:00 - 16:00 Data acquisition with LabVIEW Language: English and French Free special seminar. Registration is recommended with National Instruments Swi...

  16. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    2004-01-01

    Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrate unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). • 9:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) • 10:30 - 10:45 coffee • 10:45 - 13:00 (second part)...

  17. TECHNICAL TRAINING SEMINAR

    CERN Multimedia

    2004-01-01

    Tuesday 3 February 2004 From 09:00 to 13:30 - Training Centre Auditorium - bldg. 593, room 11 USB (Universal Serial Bus) CYPRESS Seminar Claudia Colombini, Field Application Engineer CYPRESS ActiveComp Electronic GmbH D-85077 MANCHING, Germany As a pioneer in USB, CYPRESS sets the standard for cost-effective solutions without sacrificing functionality, performance or reliability. Having shipped over 200 million USB devices, Cypress is the undisputed market leader and demonstrate unmatched USB expertise. With the industry's broadest selection of USB solutions, Cypress has the right silicon, software and support for every USB application, from Low-speed to High-Speed and USB On-The-Go (OTG). • 09:00 - 10:30 Overview of USB systems. USB CYPRESS product overview. Peripherals: Low Speed, Full Speed, High Speed (1.1 and 2.0). Hub Solutions, Embedded Host Solutions, On-The-Go (OTG) and wireless USB. USB Development Tools (first part) • 10:30 - 10:45 coffee • 10:45 - 13:00 (second part)...

  18. Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency

    Directory of Open Access Journals (Sweden)

    Danilo Fintini

    2009-07-01

    Full Text Available Danilo Fintini, Claudia Brufani, Marco CappaEndocrinology Unit, “Bambino Gesù” Children’s Hospital-IRCCS, Rome, ItalyAbstract: Growth hormone insensitivity syndrome (GHI or insulin-like growth factor-1 (IGF-1 deficiency (IGFD is characterized by deficit of IGF-1 production due to alteration of response of growth hormone (GH receptor to GH. This syndrome is due to mutation of GH receptor or IGF-1 gene and patients affected showed no response to GH therapy. The only treatment is recombinant IGF-1 (mecasermin, which has been available since 1986, but approved in the United States by the US Food and Drug Administration only in 2005 and in Europe by the European Medicines Agency in 2007. To date, few studies are available on long-term treatment with mecasermin in IGFD patients and some of them have a very small number of subjects. In this review we discuss briefly clinical features of severe primary IGFD, laboratory findings, and indications for treatment. Results of long-term therapy with rhIGF1 (mecasermin in patients affected by severe primary IGFD and possible side effects are explained.Keywords: mecasermin, therapy, Laron syndrome, IGF-1

  19. A Bayesian Framework for Multiple Trait Colo-calization from Summary Association Statistics.

    Science.gov (United States)

    Giambartolomei, Claudia; Zhenli Liu, Jimmy; Zhang, Wen; Hauberg, Mads; Shi, Huwenbo; Boocock, James; Pickrell, Joe; Jaffe, Andrew E; Pasaniuc, Bogdan; Roussos, Panos

    2018-03-19

    Most genetic variants implicated in complex diseases by genome-wide association studies (GWAS) are non-coding, making it challenging to understand the causative genes involved in disease. Integrating external information such as quantitative trait locus (QTL) mapping of molecular traits (e.g., expression, methylation) is a powerful approach to identify the subset of GWAS signals explained by regulatory effects. In particular, expression QTLs (eQTLs) help pinpoint the responsible gene among the GWAS regions that harbor many genes, while methylation QTLs (mQTLs) help identify the epigenetic mechanisms that impact gene expression which in turn affect disease risk. In this work we propose multiple-trait-coloc (moloc), a Bayesian statistical framework that integrates GWAS summary data with multiple molecular QTL data to identify regulatory effects at GWAS risk loci. We applied moloc to schizophrenia (SCZ) and eQTL/mQTL data derived from human brain tissue and identified 52 candidate genes that influence SCZ through methylation. Our method can be applied to any GWAS and relevant functional data to help prioritize disease associated genes. moloc is available for download as an R package (https://github.com/clagiamba/moloc). We also developed a web site to visualize the biological findings (icahn.mssm.edu/moloc). The browser allows searches by gene, methylation probe, and scenario of interest. claudia.giambartolomei@gmail.com. Supplementary data are available at Bioinformatics online.

  20. Golimumab in unresponsive ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Lippert E

    2014-05-01

    Full Text Available Elisabeth Lippert, Martina Müller, Claudia Ott University Hospital Regensburg, Department of Internal Medicine I, Regensburg, Germany Abstract: Ulcerative colitis (UC is a chronic inflammation mainly affecting the colon mucosa. It predominantly occurs in younger patients. Until recently, the main goals in the treatment of UC were to temper the symptoms, such as diarrhea, pain, and weight loss, by using mesalazine and steroids. With newer medications, such as immunomodulators (thiopurines and the biologics providing blockade of tumor necrosis factor (TNF, the goals of the therapy in UC have changed to long-term remission and mucosal healing. The first available anti-TNF therapy in UC included infusion therapy with infliximab every few weeks. In 2012, subcutaneously administered adalimumab gained approval for the treatment of UC in Germany. In patients with a mild disease, therapy with mesalazine, orally or topically, can be sufficient. In patients with moderate to severe disease, therapy with azathioprine or anti-TNF is often required to reach disease control; however, this is only efficient in about two-thirds of patients. Some patients either show no response or a lost response while on treatment. So, further medical options are warranted in the treatment of UC. With golimumab, a new approach in the treatment of mild to moderate UC recently became available in Germany and is a promising new option in the therapy regimen for patients with UC. Keywords: anti-TNF, biological therapy, inflammatory bowel disease

  1. Teaching Library: Vermittlung von Informationskompetenz an medizinischen Bibliotheken

    Directory of Open Access Journals (Sweden)

    Bauer, Bruno

    2014-08-01

    Full Text Available [english] The focus of the current issue 1-2/2014 of GMS Medizin – Bibliothek – Information is on “Teaching Library: information literacy instruction at medical libraries”. The authors in this issue are Marina Betker & Annette Kustos (Literature research training in health sciences in a new academic library – straight through and strategic planning: the concept of the “hsg Bochum”, Simone Waldboth (Integration of e-learning in the lecture “Information Literacy” at the Provincial College for Health-Care Professions „Claudiana“, Michaele Adam & Jens Mittelbach (Shaping the Future at the SLUB Dresden with Information Literacy in the Research Cycle, Gregor Steinrisser (Sucessfully failing – Fiction and Friction of a teaching library in university and clinical daily routine, Melanie Kintzel & Norbert Sunderbrink (Information literacy classes at the Medical Library of the University Medical Center Hamburg-Eppendorf, Markus Schmiel (The teaching and learning concept of the Library of the Hannover Medical School, Jutta Matrisciano & Martina Semmler-Schmetz (Teaching Library – Realization of a concept with many facets at the Library for the Medical Faculty of Mannheim, Karin Cepicka („Teaching Library“ at the Library oft the Medical University Vienna, Helmut Dollfuß (Library user education for the new curriculum at the Medical University Vienna, Manuela Rohrmoser & Irene Schachl (The cooperations of teaching librarians at Vienna University Library und Claudia Hausberger & David Frank (Curriculum reform – a work report from the Library of the University of Veterinary Medicine Vienna.

  2. Imitation and communication skills development in children with pervasive developmental disorders

    Directory of Open Access Journals (Sweden)

    Andrea De Giacomo

    2009-06-01

    Full Text Available Andrea De Giacomo1, Claudia Portoghese1, Domenico Martinelli2, Isabella Fanizza1, Luciano L’Abate3, Lucia Margari11Child Neurological and Psychiatric Unit, Department of Neurological and Psychiatric sciences, University of Bari, Italy; 2Department of Biomedical science and Oncology, University of Bari, Italy; 3Department of Psychology, Georgia State University Abstract: This study evaluates the correlation between failure to develop spontaneous imitation and language skills in pervasive developmental disorders. Sixty-four children between the age of 3 and 8 years were assessed using the Autism Diagnostic Interview-Revised (ADI-R, the Childhood Autism Rating Scale (CARS, and the Autism Diagnostic Observation Schedule (ADOS, as well as direct observation of imitation. The sample was subdivided into a verbal and a nonverbal group. Analysis of mean scores on the CARS “imitation” items and of ADI-R “spontaneous imitation” and “pointing to express interest” revealed a statistically significant difference between verbal and nonverbal groups, with more severe impairment/higher scores in the nonverbal than the verbal group. These results suggest that nonverbal children have specifically impaired imitation and pointing skills.Keywords: autism, imitation, communication, language, pointing

  3. The National Acupuncture Detoxification Association protocol, auricular acupuncture to support patients with substance abuse and behavioral health disorders: current perspectives

    Directory of Open Access Journals (Sweden)

    Stuyt EB

    2016-12-01

    Full Text Available Elizabeth B Stuyt,1 Claudia A Voyles2 1Department of Psychiatry, University of Colorado Health Sciences Center, Pueblo, CO, 2Department of Clinical Studies, AOMA Graduate School of Integrative Medicine, Austin, TX, USA Abstract: The National Acupuncture Detoxification Association (NADA-standardized 3- to 5-point ear acupuncture protocol, born of a community-minded response to turbulent times not unlike today, has evolved into the most widely implemented acupuncture-assisted protocol, not only for substance abuse, but also for broad behavioral health applications. This evolution happened despite inconsistent research support. This review highlights the history of the protocol and the research that followed its development. Promising, early randomized-controlled trials were followed by a mixed field of positive and negative studies that may serve as a whole to prove that NADA, despite its apparent simplicity, is neither a reductive nor an independent treatment, and the need to refine the research approaches. Particularly focusing on the last decade and its array of trials that elucidate aspects of NADA application and effects, the authors recommend that, going forward, research continues to explore the comparison of the NADA protocol added to accepted treatments to those treatments alone, recognizing that it is not a stand-alone procedure but a psychosocial intervention that affects the whole person and can augment outcomes from other treatment modalities. Keywords: National Acupuncture Detoxification Association (NADA, ear acupuncture, acudetox, addiction, mental health, trauma

  4. Defective DNA repair mechanisms in prostate cancer: impact of olaparib

    Directory of Open Access Journals (Sweden)

    De Felice F

    2017-03-01

    Full Text Available Francesca De Felice,1 Vincenzo Tombolini,1 Francesco Marampon,2 Angela Musella,3 Claudia Marchetti3 1Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, 2Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L’Aquila, L’Aquila, 3Department of Gynecological and Obstetrical Sciences and Urological Sciences, “Sapienza” University of Rome, Rome, Italy Abstract: The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1 and breast cancer 2 gene (BRCA2 mutations are implicated in the highest risk of prostate cancer (PC predisposition and aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP proteins play a key role in DNA repair mechanisms and represent a valid target for new therapies. Olaparib is an oral PARP inhibitor that blocks DNA repair pathway and coupled with BRCA mutated-disease results in tumor cell death. In phase II clinical trials, including patients with advanced castration-resistant PC, olaparib seems to be efficacious and well tolerated. Waiting for randomized phase III trials, olaparib should be considered as a promising treatment option for PC. Keywords: prostate cancer, metastatic disease, castration resistant, BRCA, DNA-repair, PARP, olaparib

  5. A negra que não está na capa de revista: debates sobre raça e gênero

    Directory of Open Access Journals (Sweden)

    Gabrielle Vivian Bittelbrun

    2016-06-01

    Full Text Available As capas das revistas femininas são conhecidas por destacar personalidades que sejam referenciais de beleza, ícones de estilo de vida e reconhecidas pelo grande público. Mas, no que se refere à aparência, nota-se a seleção quase absoluta de personagens brancas, o que pode servir como pano de fundo para se analisar a temática racial no Brasil. Afinal, enquanto contribuem para a manutenção do corpo branco em um lugar privilegiado, revistas consolidadas no mercado editorial brasileiro, como é o caso dos títulos Claudia e TPM, não deixam de reforçar a invisibilização das negras. Nesse espaço, pretende-se discutir tais questões, admitindo-se ainda que são resultado de um processo histórico, remetendo à ideologia de branqueamento, ao mesmo tempo em que escondendo discriminações por baixo da problemática máxima de “democracia racial”. Faz-se indispensável também debater como o quesito “raça” se delineou no contexto brasileiro e levantar possibilidades de subversão a partir do uso político do termo, defendido por Guimarães (2002 e Schwarcz (2012.

  6. An approach to "The Milk of Sorrow" as a hispanic intercultural narrative film

    Directory of Open Access Journals (Sweden)

    Italo Oscar Riccardi León

    2015-09-01

    Full Text Available The following article aims to develop a Hispanic intercultural cinematic study of the film “The Milk of Sorrow,” written and directed by the Peruvian filmmaker Claudia Llosa that was awarded the Golden Bear at the Berlin Film Festival in 2009. The plot of the movie tells the story of Fausta, a young girl descendant of Amerindians who suffers from a rare disease called “milk of sorrow” or “shock syndrome”, the name given to a supposed disease transmitted by fear and suffering of the mother for her child through breast milk reaching the daughters of women who were raped by terrorists or the Peruvian army soldiers in the decade of the eighties, a time of social and political instability in recent history of Peru. The connection between cinema, society and culture emerged significant and close relations from the perspective of an intercultural film that, according Hudson (2010, attempts to translate into images the experience of living between two or more different cultures and societies that view new ways of thinking and knowledge and can be considered a shared movie for people who have suffered displacement and who lived hybrid modes, as the case of the film “the Milk of Sorrow”.

  7. Development of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency

    Directory of Open Access Journals (Sweden)

    Claudia A Montiel-Equihua

    2009-12-01

    Full Text Available Claudia A Montiel-Equihua, Adrian J Thrasher, H Bobby GasparCentre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, UKAbstract: The history of stem cell gene therapy is strongly linked to the development of gene therapy for severe combined immunodeficiencies (SCID and especially adenosine deaminase (ADA-deficient SCID. Here we discuss the developments achieved in over two decades of clinical and laboratory research that led to the establishment of a protocol for the autologous transplant of retroviral vector-mediated gene-modified hematopoietic stem cells, which has proved to be both successful and, to date, safe. Patients in trials in three different countries have shown long-term immunological and metabolic correction. Nevertheless, improvements to the safety profile of viral vectors are underway and will undoubtedly reinforce the position of stem cell gene therapy as a treatment option for ADA-SCID.Keywords: adenosine deaminase, severe combined immunodeficiency, gene therapy, hematopoietic stem cell, retrovirus, clinical trial

  8. Lóxoro, traces of a contemporary Peruvian genderlect

    Directory of Open Access Journals (Sweden)

    Luis Miguel Rojas-Berscia

    2016-06-01

    Full Text Available Not long after the premiere of Loxoro in 2011, a short-film by Claudia Llosa which presents the problems the transgender community faces in the capital of Peru, a new language variety became visible for the first time to the Lima society. Lóxoro [‘lok.so.ɾo] or Húngaro [‘uŋ.ga.ɾo], as its speakers call it, is a language spoken by transsexuals and the gay community of Peru. The first clues about its existence were given by a comedian, Fernando Armas, in the mid 90’s, however it is said to have appeared not before the 60’s. Following some previous work on gay languages by Baker (2002 and languages and society (cf. Halliday 1978, the main aim of the present article is to provide a primary sketch of this language in its phonological, morphological, lexical and sociological aspects, based on a small corpus extracted from the film of Llosa and natural dialogues from Peruvian TV-journals, in order to classify this variety within modern sociolinguistic models (cf. Muysken 2010 and argue for the “anti-language” (cf. Halliday 1978 nature of it.

  9. The midwife figure: a historiographical inquiry

    Directory of Open Access Journals (Sweden)

    Clotilde Cicatiello

    2013-10-01

    Full Text Available The history of midwifery, fairly disregarded by Italian historiography, results crucial in order to fully understand both the role of women and of the foundation of the family in post-unification Italy. It firmly highlights the complexity, the undertones and, sometimes, the contradictions of the female models. The historical research, mainly in the English area, has fully recognized the indisputable significance of the midwives’ role. As a matter of fact, they emerge as representatives of medical professions in the volume by Willem Tousijn, Il sistema delle occupazioni sanitarie (2000, which combines both historical reconstruction and sociological survey. If, on the one hand, the history of midwifery is quite acquainted for the 17th and 18th centuries, thanks to the works by Mireill Laget (1982, and by Jacques Gélis (1988, on the other hand, however, the 19th century still remains to be written for the great part. In Italy, Laura Guidi, Claudia Pancino and Alessandra Gissi have traced an outline of the midwives’ path for their professional achievement throughout the 19th and the 20th centuries. This article briefly reviews these themes, rereading the texts and focusing, in particular, on the question of the professionalization of the midwife and on its actual recognition as a professional figure.

  10. Osteoporosis in men: its pathophysiology and the role of teriparatide in its treatment

    Directory of Open Access Journals (Sweden)

    Claudia Gagnon

    2008-12-01

    Full Text Available Claudia Gagnon, Vivien Li, Peter R EbelingDepartment of Medicine, University of Melbourne, Melbourne, AustraliaAbstract: As the population ages, the burden of osteoporosis in men is expected to rise. Implementation of preventive measures such as falls prevention strategies, exercise and adequate calcium and vitamin D intake is recommended. However, when the diagnosis of osteoporosis is made, effective treatments need to be initiated to prevent fractures. As opposed to postmenopausal women, reduced bone formation is the predominant mechanism of age-related bone loss in men, making anabolic agents a logical treatment option for men with osteoporosis. Teriparatide is the only anabolic agent currently approved for treatment of osteoporosis in men. This paper summarizes the mechanism of action of teriparatide, as well as its tolerability and safety. Furthermore, the evidence supporting the efficacy of teriparatide treatment in men with osteoporosis is reviewed and its current role in the management of osteoporosis in men is discussed.Keywords: osteoporosis, pathophysiology, treatment, parathyroid hormone, men

  11. Behind the machines

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    One of the first things we think about when someone mentions physics is the machines. But behind the machines, there are the men and women who design, build and operate them. In an exhibition at the Thinktank planetarium’s art gallery in Birmingham (UK), Claudia Marcelloni and her husband Neal Hartman—she is a photographer and Outreach Officer for ATLAS, while he is an engineer working on the ATLAS pixel detector—explore the human side of scientists.   The exhibition at the Thinktank Planetarium art gallery, Birmingham (UK). It all began two years ago with the publication of Exploring the mystery of matter, a book about ATLAS. “A Norwegian physicist friend, Heidi Sandaker, saw my photographs and suggested that I display them in a museum. I thought this was an interesting idea, except that the photos consisted entirely of depictions of machinery, with human beings completely absent. For me, showing the people who are behind the machines and the fascination ...

  12. Breast cancer in Mongolia: an increasingly important health policy issue

    Directory of Open Access Journals (Sweden)

    Demchig D

    2017-01-01

    Full Text Available Delgermaa Demchig, Claudia Mello-Thoms, Patrick C Brennan Medical Image Optimization and Perception Group (MIOPeG, Faculty of Health Science, The University of Sydney, Sydney, NSW, Australia Abstract: Breast cancer is a leading cause of cancer-related death for women in both developed and developing countries. The incidence and mortality of breast cancer in Mongolia, while low compared with other counties, has been increasing on an annual basis. In addition, in Mongolia, approximately 90% of the patients are diagnosed at a late stage, resulting in high mortality, with the majority of individuals diagnosed with breast cancer dying within 5 years of diagnosis. Breast cancer screening plays an important role in reducing mortality in Western countries and has been adopted by a number of Asian countries; however, no such approach exists in Mongolia. In a country of limited resources, implementation of expensive health strategies such as screening requires effective allocations of resources and the identification of the most effective imaging methods. This requirement relies on recent accurate data; however, at this time, there is a paucity of information around breast cancer in Mongolia. Until data around features of the disease are available, effective strategies to diagnose breast cancer that recognize the economic climate in Mongolia cannot be implemented and the impact of breast cancer is likely to increase. Keywords: incidence, mortality, breast screening, Mongolia

  13. Preparing a new book on ATLAS

    CERN Multimedia

    Claudia Marcelloni de Oliveira

    A book about the ATLAS project and the ATLAS collaboration is going to be published and available for sale in mid 2008. The book is intended to be a symbol of appreciation for all the people from ATLAS institutes, triggering fond memories through photos, interviews, short commentaries and anecdotes about the daily life and milestones encountered while designing, constructing and completing ATLAS. We would like to give you the opportunity to collaborate with this project in two different ways: Firstly, please send us the best anecdotes related to ATLAS that you remember. To submit anecdotes, send an email to Claudia.Marcelloni@cern.ch. Secondly, you are invited to participate in our PHOTO COMPETITION. Please send the best photos you have of ATLAS attached with a description, the location, and date taken. The categories are: Milestones in the process of designing and building the detector, People at work and Important gatherings. To submit photos you should go to the CDS page and select ATLAS Photo Competi...

  14. Behind every great detector, there are lots of great people!

    CERN Multimedia

    Pauline Gagnon

    Remember all these pictures you sent out last year for a poster project? At last, after a few unsuccessful attempts, the "ATLAS People poster" is out. This mosaic picture was built out of the 600 or so photos collected for the poster, including the 120 or so portraits taken by Claudia Marcelloni di Oliveira. Each photo appears roughly 15 times to fill the 9000 pixels of the poster. Sorry: there is no key to help you locate your photo but you can buy a copy of the poster at the ATLAS secretariat to stare at it as much as you like. They are on sale for only 4 CHF (or 3 CHF a piece for 10 or more copies). I hope many of you will display it in your office and at your home institute to give a sense of the size of the human effort involved to build this experiment and make it a bit less anonymous. The new poster showing the faces of many of those who have contributed to the making of the ATLAS detector.

  15. „Geschlechter-Dialoge?“ “Gender-Dialogues?”

    Directory of Open Access Journals (Sweden)

    Regina Frey

    2000-07-01

    Full Text Available Der Band ist das Ergebnis einer Vorlesungsreihe an der Freien Universität. Sieben (männliche Wissenschaftler unterschiedlicher Fachrichtungen stellen dabei Impulse feministischer Theorien für ihre Disziplin vor. Claudia von Braunmühl greift also eine alte Frage der Frauen- und Geschlechterforschung auf: Inwieweit wirken die Arbeiten feministischer Wissenschaften in den ‚Malestream‘ zurück? Die Einzelbeiträge stellen sich auf sehr unterschiedliche Weise der feministischen Herausforderung.In ‘The Blocked Dialogue’ seven (male professors deal with the impact of feminist theory on their academic disciplines. It shows that the authors, covering a range of subjects (for example International Relations, Education, and Landscape Planning, react very differently on the feminist challenge. Some of them are in line with late debates and manage to discuss feminist impulses in a fruitful and constructive way, others seem to be far from the state-of-the-art of feminist theory within their discourses.

  16. Captivity mark as Foundation of Civil Liability for Risk in Prol Consumer

    Directory of Open Access Journals (Sweden)

    Fernando Antônio de Vasconcelos

    2016-06-01

    Full Text Available The postmodern society can be seen as risk society. From the Ulrich Beck’s idea that the acquired knowledge allows the current development model, but its generates uncontrollable risks, this study attempts to make a validation of trademark captivity theory as the basis for civil liability for risk. The strength of the brands as fundamental goals in today’s economic process is seen as a vector of liability for consumers as a vulnerable class. The difficulty of consumers in the process of accountability for damages suffered in their relations is still present. The supply process is complex and is formed by a network arrangements which stresses the consumer’s vulnerability. The trademark captivity allows the identification of an economic group participants by sharing the brand. The proposal in this article, is to strengthen the idea of   captivity mark as accountability paradigm from the brand with the theory of risk, examining its feasibility framing the sole paragraph of Article 927 of the Brazilian Civil Code.The methodology will be based on a legal-economic aspect and depart from an inductive analysis and bibliographic surveys, with the theoretical framework of Ulrich Beck, Antonny Giddens and Claudia Lima Marques.

  17. Rational and Emotional Communication in Advertising in Women's Magazines in Brazil

    Directory of Open Access Journals (Sweden)

    Edward Robinson Marin

    2014-01-01

    Full Text Available This article investigated the incidence of rational and emotional arguments in messages from 5.536 advertisements of six women's magazines in Brazil (Claudia, Nova, Estilo, Marie Claire, Elle and Gloss, published between May / 2008 and August / 2009. The methodology was based on an exploratory study, supported on a scale of 14 items, by Resnik and Stern (1977, which recommend matching appeals to attitude toward the product, that is, use informative advertising, based on rational appeals for products in which the consumer attitude is predominantly cognitive. To assess the emotional content, we used the scale of eight items of Plutchik (1980, represented by the primary emotions - Anger, Fear, Sadness, Disgust, Surprise, Curiosity, Acceptance and Joy. Data analysis included the frequency of the two appeals in the general category (durables, non-durables and services, product, and correspondence analyzes were used to identify the prevalence of two types of arguments in selected magazines. The results show the concentration of ads on non-durable goods, followed by the category of services, that overcomes the advertisings on durables. The study also analyzes the incidence of emotional and rational arguments by product category and by magazine.

  18. Getting Lost in Tokyo

    Directory of Open Access Journals (Sweden)

    Raymond Lucas

    2014-07-01

    Full Text Available This paper explores the potential for using alternative forms of inscriptive practice to describe the urban space of the Tokyo Subway. I begin with an account of the process of getting lost in Shinjuku Subway Station in the heart of Tokyo. This station represents a limit condition of place, being dense and complex beyond the powers of traditional architectural representation. The station is explored through serial translations, beginning with narrative, moving to a flowchart diagram, Laban dance notation, recurring motifs and archetypes, architectural drawing, photography, and cartography. As Claudia Brodsky Lacour and Tim Ingold describe, the form our inscriptive practices take are crucial to the ways in which we conceptualise those places. How much of the experience of a place is lost in the traditional inscriptive practices of the architect? This description of the urban space of the Tokyo subway forms the basis for an extended study exploring the description of this experience of place, and the power of such description to theorise space. The ultimate aim of this is to shift the focus of urban design away from geometric principles and towards the experiences that might be enjoyed in such places.

  19. Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation

    Directory of Open Access Journals (Sweden)

    Mariagrazia Di Marco

    2009-12-01

    Full Text Available Mariagrazia Di Marco1, Shaharum Shamsuddin2, Khairunisak Abdul Razak3, Azlan Abdul Aziz4, Corinne Devaux1, Elsa Borghi1, Laurent Levy1, Claudia Sadun51Nanobiotix, Paris, France; 2School of Health Sciences, Health Campus Universiti Sains Malaysia, Kelantan, Malaysia; 3School of Materials and Mineral Resources Engineering, Engineering Campus, 4School of Physics, Universiti Sains Malaysia, Penang, Malaysia; 5Department of Chemistry, Sapienza, University of Rome, Rome, ItalyAbstract: The latest development of protein engineering allows the production of proteins having desired properties and large potential markets, but the clinical advances of therapeutical proteins are still limited by their fragility. Nanotechnology could provide optimal vectors able to protect from degradation therapeutical biomolecules such as proteins, enzymes or specific polypeptides. On the other hand, some proteins can be also used as active ligands to help nanoparticles loaded with chemotherapeutic or other drugs to reach particular sites in the body. The aim of this review is to provide an overall picture of the general aspects of the most successful approaches used to combine proteins with nanosystems. This combination is mainly achieved by absorption, bioconjugation and encapsulation. Interactions of nanoparticles with biomolecules and caveats related to protein denaturation are also pointed out. A clear understanding of nanoparticle-protein interactions could make possible the design of precise and versatile hybrid nanosystems. This could further allow control of their pharmacokinetics as well as activity, and safety.Keywords: nanoparticles, drug delivery, proteins, polypeptides, absorption, bioconjugation, encapsulation

  20. ATLAS book wins the IPPY awards

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    Hunting the Higgs, published by Papadakis Publishers in collaboration with the ATLAS experiment has won the Bronze prize in the Science category of the Independent Publisher Book Awards (see here). The Award ceremony will be held on 28 May in New York on the eve of the BookExpo America (see here).   “Ours is a souvenir book that gives viewers a glimpse of the discovery of the Higgs boson and the collaborative effort behind it of thousands of scientists in ATLAS,” says Claudia Marcelloni, communications officer of the ATLAS Experiment, who worked on the book with freelance science writer Colin Barras. “The science is noble and the collaboration heartwarming, and the IPPY Award is a great way to celebrate the mind-blowing story of human achievement.” Hunting the Higgs is the inside story of the ATLAS experiment at the Large Hadron Collider. It tells the journey of the experiment, from before the detector was born to the announcement of the discovery of t...

  1. Smart Energy 2012. How smart is the way towards the turnaround in the energy policy; Smart Energy 2012. Wie smart ist der Weg zur Energiewende?

    Energy Technology Data Exchange (ETDEWEB)

    Grossmann, Uwe; Kunold, Ingo (eds.)

    2012-07-01

    The contribution under consideration contains fifteen contributions of well-known authors from commercial enterprises, public institutions and universities on smart energy: (1) Smart grids, but surely (Claudia Eckert); (2) Requirements concerning the further development of data protection and data security as part of the technological change (Reinhold Harnisch); (3) Standardization in the smart grid (Harald Orlamuender); (4) IEC 61850 - The standard for energy automation (Georg Harnischmacher); (5) Smart City, the intelligent grid in the city (Michael Laskowski); (6) IKT is a basis for a real smart power distribution system (Justus Bross); (7) Power transparency and optimized building optimization by means of a holistic automation concepts (Joerg Wollert); (8) Distributed architecture for a balancing aggregation of consumption and generation of power in private households (Kilian Hemmeboehle); (9) Development of an e-energy market place and first experiences from the field test in the E-DeMa project (Bernd Werner); (10) Smart metering rollout pilot ''30,000er'' (Axel Lauterkorn); (11) Experiences with the connexion and communication to smart meters in the project eTelligence (Guenter Pistoor); (12) Smart Phoenix - Intelligent energy networks in Dortmund (Roland Brueggemann); (13) Smart planning (C. Engels); Intelligent house control by means of smart metering (Sabine Wieland); (14) Dynamic billing of energy and value-added service in the networked home (Frank C. Bormann).

  2. Lift the quilt in case of atrial fibrillation and disc prolapse

    Directory of Open Access Journals (Sweden)

    Bastovansky A

    2012-06-01

    Full Text Available Adam Bastovansky,1 Kathrin Ziegler,2 Claudia Stöllberger,2 Josef Finsterer31Department of Radiology, 2Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria; 3Danube University Krems, Krems, AustriaBackground: Peripheral embolism to the lower extremities may mimic disc prolapse with severe consequences.Case report:  A 71-year-old male with a history of chronic alcoholism developed low back pain radiating to both lower extremities in a nonradicular distribution and bilateral dysesthesias of the distal lower legs after lifting a heavy weight. Given that magnetic resonance imaging (MRI of the lumbar spine showed disc herniation in L3/4 and L4/5, he was scheduled for laminectomy but was unable to undergo surgery due to thrombocytopenia. After transfer to another hospital, persistence of symptoms and signs, absent pulses on the distal lower legs, and rhabdomyolysis with temporary renal insufficiency, peripheral embolism with compartment syndrome was suspected. Magnetic resonance angiography revealed occlusion of the right superficial femoral artery and long high-grade stenosis of the left superficial and profound femoral arteries and distal arteries. He successfully underwent embolectomy and fasciotomy.Conclusions: If lumbar pain is not radicular, peripheral pulses are minimally palpable, and distal limbs are cold and show livid decolorization, peripheral embolism is much more likely than disc herniation, particularly if the patient's history is positive for atrial fibrillation. MRI of the lumbar spine must be interpreted in conjunction with clinical presentation.Keywords: embolism, compartment syndrome, neurosurgery, embolectomy, fasciotomy, rhabdomyolysis

  3. Drug abuse in athletes

    Directory of Open Access Journals (Sweden)

    Reardon CL

    2014-08-01

    Full Text Available Claudia L Reardon, Shane Creado Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Abstract: Drug abuse occurs in all sports and at most levels of competition. Athletic life may lead to drug abuse for a number of reasons, including for performance enhancement, to self-treat otherwise untreated mental illness, and to deal with stressors, such as pressure to perform, injuries, physical pain, and retirement from sport. This review examines the history of doping in athletes, the effects of different classes of substances used for doping, side effects of doping, the role of anti-doping organizations, and treatment of affected athletes. Doping goes back to ancient times, prior to the development of organized sports. Performance-enhancing drugs have continued to evolve, with “advances” in doping strategies driven by improved drug testing detection methods and advances in scientific research that can lead to the discovery and use of substances that may later be banned. Many sports organizations have come to ban the use of performance-enhancing drugs and have very strict consequences for people caught using them. There is variable evidence for the performance-enhancing effects and side effects of the various substances that are used for doping. Drug abuse in athletes should be addressed with preventive measures, education, motivational interviewing, and, when indicated, pharmacologic interventions. Keywords: doping, athletes, steroids, drug abuse, mental illness

  4. Persuasive Strategies towards Racial Appeal in Tony Morrison’s The Bluest Eye

    Directory of Open Access Journals (Sweden)

    Somayeh Shabani

    2017-12-01

    Full Text Available Racism is the main theme in Toni Morisson’s The Bluest Eye. The little black girl’s long lasting yearn for blue eyes has been linked to the standards of America’s society in 1940’s which associated beauty to being white. Although instances of racism are rampant throughout the story, previous studies have not attempted to determine the type of persuasive strategies used by Toni Morrison to justify racism in the novel. In this paper, the author made use of Aristotle’s concepts of ethos, logos, and pathos, as 3 main dimensions of persuasion to determine the strategies used in the novel by the narrator-Claudia. Descriptive qualitative analysis of the novel’s text revealed that the author has made use of all these strategies. Pathos was observed in form of feelings of fear, anger and hatred. Logos was observed in the logic of the grown up society of America about being white and ethos was found among the black who themselves credited the whites over their own race.

  5. Happy birthday, Jack Steinberger

    CERN Multimedia

    CERN Bulletin

    2016-01-01

    Even if he’s recently stopped coming to CERN on his bike, Jack Steinberger and his piercing blue eyes are still regular visitors to our corridors. As he celebrates his 95th birthday, we pay tribute to one of CERN’s greatest scientists.   Jack Steinberger in 2008, pictured on the occasion of the "Accelerating Nobel" exhibition. (Image: Claudia Marcelloni/CERN) Jack emigrated from Germany to the United States in 1934 to escape the persecution of the Jews. He later went on to study under Enrico Fermi in Chicago and in the 1950s, he contributed to the development of bubble chambers. Using this new detection apparatus, he was involved in the myriad discoveries and results that led to the construction of the Standard Model. In 1961, while at Columbia University (New York), he took part in the first experiment with a high-energy neutrino beam, which gave rise to the discovery of the muon neutrino. This discovery was awarded the&a...

  6. Gastrointestinal obstruction caused by solidification and coagulation of enteral nutrition: pathogenetic mechanisms and potential risk factors

    Directory of Open Access Journals (Sweden)

    Leonello G

    2018-04-01

    Full Text Available Grazia Leonello,1 Antonio Giacomo Rizzo,1 Viviane Di Dio,2 Antonio Soriano,3 Claudia Previti,3 Grazia Giulia Pantè,3 Claudio Mastrojeni,1 Sebastiano Pantè1 1Department of Human Pathology of Adults and Evolutive Era “Gaetano Barresi”, University of Messina, Messina, Italy; 2Health Research Institute Bonino Pulejo, Piemonte Hospital, Messina, Italy; 3Department of Medical and Surgery Science, University of Messina, Messina, Italy Abstract: Enteral nutrition (EN is preferred in order to provide nutrition and reduce catabolism in critically ill patients. Recent studies suggest that the use of EN is successful and complications are rare. However, an underestimated mechanical complication of tube feedings seen in critically ill patients is the coagulation and solidification of the EN causing gastrointestinal obstruction. This report describes two clinical cases (1.23% of all cases seen at our clinic of obstruction and perforation of the small bowel secondary to the solidification of EN. The understanding and early recognition of this potential complication are essential for the prevention and successful treatment of this condition. Keywords: enteral nutrition, gastrointestinal contents, intestinal obstruction, small-bowel bezoar

  7. Annual review of energy and the environment. Volume 23

    Energy Technology Data Exchange (ETDEWEB)

    Socolow, R.H. [ed.] [Princeton Univ., NJ (United States); Anderson, D. [ed.] [Imperial College of Science, Technology, and Medicine, London (United Kingdom); Harte, J. [ed.] [Univ. of California, Berkeley, CA (United States)

    1998-12-31

    Thirteen papers are included in this volume. The titles and authors are: From Physics to Development Strategies by Jose Goldemberg; Rewards and Penalties of Monitoring the Earth by Charles D. Keeling; Science and Nonscience Concerning Human-Caused Climate Warming by J. D. Mahlman; Consumption of Materials in the United States, 1990--1995 by Grecia Matos and Lorie Wagner; Future Technologies for Energy-Efficient Iron and Steel Making by Jeroen de Beer, Ernst Worrell, and Kornelis Blok; The O{sub 2} Balance of the Atmosphere: A Tool for Studying the Fate of Fossil Fuel CO{sub 2} by Michael L. Bender, Mark Battle, and Ralph F. Keeling; Mexican Electric End-Use Efficiency: Experiences to Date by Rafael Friedmann and Claudia Sheinbaum; Drinking Water in Developing Countries by Ashok Gadgil; Engineering-Economic Studies of Energy Technologies to Reduce Greenhouse Gas Emissions: Opportunities and Challenges by Marilyn A. Brown, Mark D. Levine, Joseph P. Romm, Arthur H. Rosenfeld, and Jonathan G. Koomey; Climate Change Mitigation in the Energy and Forestry Sectors of Developing Countries by Jayant A. Sathaye and N. H. Ravindranath; Toward a Productive Divorce: Separating DOE Cleanups from Transition Assistance by M. Russell; Recycling Metals for the Environment by Iddo K. Wernick and Nickolas J. Themelis; and Environmentally Conscious Chemical Process Design by J. A. Cano-Ruiz and G. J. McRae.

  8. Speaking to the Masses – Hybrid Poetics and Marshall McLuhan’s “Newspaper Landscape”

    Directory of Open Access Journals (Sweden)

    Morrissy, Julie

    2016-12-01

    Full Text Available This essay points to structural and formal techniques in the hybrid poetries of current female North American poets writing in the book-length form. The author suggests that in their hybrid poetries, M. NourbeSe Philip, Claudia Rankine and C.D. Wright engage with Marshall McLuhan’s 1954 concept of the “newspaper landscape”. The author further argues that through such formal invention, these poets create identification points in their respective works for both traditional poetry readers and non-specialised readers. As such, the above poets encourage a hybrid audience for their hybrid poetries. Using theories by rhetoricians Kenneth Burke, and Jeffrey Walker in relation to the hybrid poetries of the above poets, this paper highlights the ability of language to direct our attention to different worldviews and the role of language in impacting audience. The author argues that the “newspaper landscape”, as seen in poetries of NourbeSe Philip, Rankine and Wright discussed herein, broadens the traditional audiences for poetry by appealing to both specialised and non-specialised readers. In making this claim, the author outlines the formal and structural elements of contemporary hybrid poetries and the ways in which such elements culminate in broader audiences and more accessible poetries. Further, and consequentially, the paper concludes by making a link between the hybrid techniques of the newspaper landscape and possible impact in the public sphere that these hybrid poetries may encourage.

  9. Visit of Danish firms at CERN

    CERN Document Server

    GS Department

    2012-01-01

    30 – 31 JANUARY 2012 09h00 to 17h00 Monday 30 January 09h00 to 17h00 Tuesday 31 January Individual interviews will take place in technicians’ offices. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details which are available from each secretariat of department or from the GS Department web pages at the following URL http://gs-dep.web.cern.ch/en/content/Industrial-Exhibitions List of Companies: Axcon APS BB Electronics A/S B.Rustfrit Stal A/S CIM Industrial Systems A/S Danfysik A/S Develco A/S Eletronic A/S GPV Group Innoware A/S JLI Vision A/S NECAS A/S NKT Cables A/S Noliac A/S Röttger’s Vaerktoj A/S   For further information please contact Claudia Bruggmann Furlan  GS-IS-LS 73312 or Caroline Laignel GS-DI 73722.

  10. Danish firms visit CERN

    CERN Multimedia

    FP Department

    2011-01-01

    30 – 31 JANUARY 2012 09:00 to 17:00 Monday 30 January 09:00 to 17:00 Tuesday 31 January Individual interviews will take place in technicians’ offices. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details available from the secretariat of their department or from the GS Department web page. List of Companies: · Axcon APS · BB Electronics A/S · B.Rustfrit Stal A/S · CIM Industrial Systems A/S · Danfysik A/S · Develco A/S · Eletronic A/S · GPV Group · Innoware A/S · JLI Vision A/S · NECAS A/S· NKT Cables A/S · Noliac A/S · Prodan A/S · Röttger’s Vaerktoj A/S · Vengcon APS For further information please contact Claudia Bruggmann Furlan  GS-IS-LS 73312 or Caroline Laignel GS-DI 73722.

  11. Expresividad, creatividad y disfrute como enigma de lo social

    Directory of Open Access Journals (Sweden)

    Diego Quattrini

    2015-05-01

    Full Text Available El libro compilado por Graciela Magallanes, Claudia Gandía y Gabriela Vergara conforma una propuesta de análisis teórico y metodológico que vehiculiza la relación entre los procesos de expresividad, creatividad y disfrute con las prácticas marcadas por la estructuración social. El contenido del mismo, logrado a partir de un conjunto de trabajos producidos en el marco de una investigación de más de dos años, da cuenta específicamente de las formas de sensibilidad y la acción colectiva que se desprenden de las experiencias de los sujetos en el carnaval en la ciudad de Villa Nueva y Villa María (Córdoba Argentina. La apuesta de los doce artículos que convoca la obra es analizar distintas formas de festividad que provocan procesos intempestivos (e inestables que se van actualizando en los intersticios y des-ajustando de las lógicas de estructuración, contribuyendo así en última instancia a visibilizar otras sensibilidades, que sin llegar a ser completamente insurgentes, hacen presentes vínculos más humanos y menos instrumentales a la lógica mercantil.

  12. Emerging targets in cancer management: role of the CXCL12/CXCR4 axis

    Directory of Open Access Journals (Sweden)

    Cojoc M

    2013-09-01

    Full Text Available Monica Cojoc,1 Claudia Peitzsch,1 Franziska Trautmann,1 Leo Polishchuk,2 Gennady D Telegeev,2 Anna Dubrovska11OncoRay National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; 2Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, UkraineAbstract: The chemokine CXCL12 (SDF-1 and its cell surface receptor CXCR4 were first identified as regulators of lymphocyte trafficking to the bone marrow. Soon after, the CXCL12/CXCR4 axis was proposed to regulate the trafficking of breast cancer cells to sites of metastasis. More recently, it was established that CXCR4 plays a central role in cancer cell proliferation, invasion, and dissemination in the majority of malignant diseases. The stem cell concept of cancer has revolutionized the understanding of tumorigenesis and cancer treatment. A growing body of evidence indicates that a subset of cancer cells, referred to as cancer stem cells (CSCs, plays a critical role in tumor initiation, metastatic colonization, and resistance to therapy. Although the signals generated by the metastatic niche that regulate CSCs are not yet fully understood, accumulating evidence suggests a key role of the CXCL12/CXCR4 axis. In this review we focus on physiological functions of the CXCL12/CXCR4 signaling pathway and its role in cancer and CSCs, and we discuss the potential for targeting this pathway in cancer management.Keywords: epithelial-to-mesenchymal transition, cancer stem cells, metastasis

  13. A viagem como experiência traumática na ficção Paisagem de Porcelana de Cláudia NIna

    Directory of Open Access Journals (Sweden)

    Bruno Cardoso

    2017-10-01

    Full Text Available O artigo analisa a representação da experiência de deslocamento no romance Paisagem de Porcelana da escritora carioca Claudia Nina. A leitura da obra focaliza os expedientes narrativos empregados pela autora no objetivo de figurar a viagem da protagonista-narradora a Holanda sob uma moldura traumática e dramática. Assim, o enredo se constrói sob uma perspectiva memorialista, conforme Cury( 2016, comumente utilizada em narrativas de viagem. A hipótese de leitura assume que a narradora, ao passo que rememora os acontecimentos traumáticos ocorridos em sua experiência de viagem a Amsterdã, produz um discurso de ficção reparando as arestas deixadas pela experiência traumática. Em consequência disso,, a possibilidade de superar a experiência traumática de viagem se viabiliza, no romance, por intermédio da criação de uma escrita ficcional sobre ela,o que se  revela como estratégia narrativa crucial para a construção do enredo.

  14. PREFACE: Young Researcher Meeting, Trieste 2013

    Science.gov (United States)

    Agostini, F.; Antolini, C.; Aversa, R.; Cattani, G.; Martinelli, M.; Mazzaferro, L.; Migliaccio, M.; Paci, F.; Pietrobon, D.; Ricci Pacifici, D.; Stellato, F.; Veneziani, M.

    2013-12-01

    YRM logo The Young Researcher Meeting (www.yrmr.it) has been a rapidly growing event for the last few years. Together with other initiatives which have emerged in several research areas, the young researcher meeting marks the awareness and the desire of PhD students, postdoctoral fellows and young researchers to play a major role in scientific progress. Devoted to the discussion and the interchange of new developments and ideas in physics, the meeting is primarily aimed at graduate students and postdoctoral researchers, who are encouraged to present their work in an informal atmosphere. One of the main purposes of the conference is to create an international network of young researchers, both experimentalists and theorists, and fruitful collaborations across the different branches of physics. Born in Rome in 2009, after three editions that strengthened it, the Young Researcher Meeting 2013 was held in Trieste. Propelled by the past success, the fourth meeting was a two-day conference on 3-4June. It was sponsored by the International School for Advanced Studies - SISSA - and the University of Padova, thus acquiring an even further international drive. In this volume, we collect some of the contributions that were presented at the conference. They cover topics in astrophysics and cosmology, particle and theoretical physics, soft and condensed matter, biophysics and medical physics. YRM Organising and Editorial Committee Fabio Agostini (fabio.agostini@roma2.infn.it) Dipartimento di Fisica, Università di Roma 'Tor Vergata' Via della Ricerca Scientifica 1, 00133 Roma, Italy Claudia Antolini (claudia.antolini@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Via Bonomea 265, 34136 Trieste, Italy Rossella Aversa (raversa@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Via Bonomea 265, 34136 Trieste, Italy Giordano Cattani (giordano.cattani@gmail.com) Matteo Martinelli (mmartin@sissa.it) SISSA - Scuola Internazionale Superiore di

  15. Apresentação Workshop Baía de Guanabara

    Directory of Open Access Journals (Sweden)

    Claudia Gutteres Vilela

    2003-01-01

    Full Text Available Ano 2003 Volume 26 - Workshop Baía de Guanabara Editor: Ismar de Souza Carvalho Coordenadora: Claudia Gutteres Vilela: Apresentação ISSN: 0101-9759 É com grande prazer que participo da edição do Anuário de 2003 do Instituto de Geociências, que inclui os trabalhos apresentados no Workshop Baía, realizado nos dias 12 e 13 de novembro de 2002, nesta instituição. O sucesso desse evento deve-se em grande parte aos trabalhos, apresentados sob a forma de palestras em mesas redondas ou painéis, por pesquisadores consagrados no Brasil e no exterior. O conteúdo dos trabalhos possui uma abrangência que se estende desde a Geologia até a Biologia, passando pela Oceanografia e Geografia, sempre com o objetivo comum de reunir dados sobre a Baía de Guanabara visando o diagnóstico ambiental. O Workshop Baía congregou diversas linhas de pesquisa desenvolvidas na Baía de Guanabara e regiões adjacentes, procurando uma integração das mesmas. Deste modo alguns trabalhos caracterizaram, em um contexto mais geral, a evolução do nível do mar na região sudeste durante o Holoceno, bem como apresentaram a neotectônica da região. Geoquímica orgânica de hidrocarbonetos e de metais pesados, sedimentologia e hidrogeologia integraram-se à distribuição de microorganismos nos sedimentos e na água, analisando diversas respostas a diferentes graus de poluição em regiões distintas. Um zoneamento ambiental ofereceu uma visão dinâmica das condições naturais e sociais do conjunto da Baía de Guanabara. A importância do workshop deve-se à busca de uma integração maior dos trabalhos acadêmicos para aplicação à gestão do desenvolvimento sustentável da Baía de Guanabara e seu entorno, que abriga a cidade do Rio de Janeiro e se constitui em uma das regiões com maior índice demográfico do Brasil. Seu impacto pode se avaliado pela presença de representantes de órgãos públicos como a SERLA, a Prefeitura de Niterói e ONGs ligadas a

  16. Conflitos socioeconômicos-ambientais relativos ao avanço do cultivo da soja em áreas de influência dos eixos de integração e desenvolvimento no Estado de Mato Grosso = The research environmental and socio-economical conflicts relative to the advance of the soybean growth in areas of influence of the integration and development axis in the state of Mato Grosso

    Directory of Open Access Journals (Sweden)

    Lunalva Moura Schwenk

    2008-10-01

    Full Text Available A pesquisa trata da espacialização da ocupação da soja, levantada por imagens de satélite, em duas áreas no Planalto e Chapada dos Parecis, estando a Área I sob influência do eixo da BR-364 e a área II da BR-163. Estudaram-se os municípios consolidados, expandindo-se ou projetando-se no cultivo da soja, motivados pela implantação de rodovias. Na Área I, estão: Brasnorte, Campos de Júlio, Sapezal e Campo Novo dos Parecis e, na Área II: Sorriso, Lucas do Rio Verde, Nova Mutum, Vera, Nova Ubiratã, Santa Carmem e Claudia. Embora a soja possibilite o crescimento econômico, contribuindo para melhorar opadrão e qualidade de vida, concomitantemente, desencadeia inúmeros conflitos ambientais, ecológicos e sociais, pois, à medida que a fronteira agrícola avança e inovações são introduzidas, mudanças radicais são provocadas na estrutura da região gerenciada pelosatores hegemônicos. A vegetação natural torna-se fragmentada e simplificada no domínio de uma monocultura cultivada com presença de tecnologia de ponta, para maior produtividade voltada à exportação. Também, assoreamento e contaminação dos rios, mudanças no regimehidrológico, processos erosivos, pressões dentro e em torno das reservas indígenas, além da incorporação desta economia pelos índios, resultando em grandes desmatamentos nas reservas, desigualdades sociais e prostituição.Addresses the spread of soybean occupation, surveyed by satellite images in two areas in the Planalto and Chapada dos Parecis. Area I is located under the influence of highway BR-364, and Area II is within the area of BR-163. The study analyzed districts that are consolidated or in the process of expanding soybean growing, motivated by highway construction. In Area I we have themunicipalities of: Brasnorte, Campos de Júlio, Sapezal and Campo Novo dos Parecis, and in Area II we have Sorriso, Lucas do Rio Verde, Nova Mutum, Vera, Nova Ubiratã, Santa Carmen and Claudia

  17. Revistas y políticas de traducción del feminismo mexicano contemporáneo Journals and translation policies of contemporary mexican feminism

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    Márgara Millán

    2009-12-01

    Full Text Available En este ensayo me centraré en el análisis de tres importantes revistas y circuitos editoriales que constituyen, desde mi perspectiva, una parte importante de la política y la visibilidad feminista en el México contemporáneo: Debate Feminista, 1990, Fem, 1976 y La Correa Feminista, 1991. Voy a analizar estas publicaciones enfatizando lo que denominaré sus "políticas de traducción", aludiendo a los conceptos de feminismo y/o de género que promueven según las autoras y críticas que traducen. La noción de "traducción" significa, en este contexto, dos cosas: la traducción de ciertos autores y teorías y la manera en que estas traducciones se alinean con el contexto político local. Leeré estas traducciones entonces, de acuerdo a cómo se incorporan y participan de un panorama político más amplio, de cómo se presentan en un marco editorial determinado y del momento en que se hacen las publicaciones, entendiendo todo esto como maneras de intervenir en la arena política local. Al entender las traducciones como políticas de intervención, asumimos que esta es una de las formas en las que los grupos feministas establecen sus vínculos, sus alianzas, y sus plataformas para relacionarse con los movimientos sociales y los actores políticos nacionales. Me referiré al espacio de diálogo entre mujeres como un espacio problemático donde participan los grupos feministas y sus agendas, y las mujeres de diversos movimientos sociales y sus agendas. El texto de Rebecca E. Biron "Feminist periodicals and political crisis in Mexico"1 fue la inspiración central de este trabajo, así como el marco propuesto por Claudia de Lima Costa2 sobre transnacionalizacióntraducción como conceptos que necesitan ser clarificados desde sus significados locales y globalesThis essay focuses on the analysis of three important journals and editorial circuits which constitute, from this perspective, a significant part of feminist policy and visibility in

  18. In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

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    Baldi G

    2014-06-01

    Full Text Available Giovanni Baldi,1 Costanza Ravagli,1 Filippo Mazzantini,1 George Loudos,2 Jaume Adan,3 Marc Masa,3 Dimitrios Psimadas,2 Eirini A Fragogeorgi,2 Erica Locatelli,4 Claudia Innocenti,5,6 Claudio Sangregorio,5,7 Mauro Comes Franchini4 1CERICOL, Sovigliana-Vinci, Italy; 2Technological Educational Institute of Athens, Athens, Greece; 3Leitat Technological Center, Barcelona, Spain; 4Department of Industrial Chemistry Toso Montanari, University of Bologna, Bologna, 5Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM, 6Dipartimento di Chimica U Schiff, Università di Firenze, Firenze, 7Centro Nazionale delle Ricerche (ICCOM – CNR, Firenze, Italy Abstract: Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide-co-glycolide-b-poly(ethylene glycol-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99mTc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99mTc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma. Keywords: magnetic nanoparticles, polymeric nanocarriers, skin cancer, hyperthermia, single-photon emission computed tomography, imaging

  19. Tinnitus: clinical experience of the psychosomatic connection

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    Salviati M

    2014-02-01

    Full Text Available Massimo Salviati,1 Francesco Saverio Bersani,1 Samira Terlizzi,1 Claudia Melcore,1 Roberta Panico,1 Graziella Francesca Romano,1 Guiseppe Valeriani,1 Francesco Macrì,1 Giancarlo Altissimi,2 Filippo Mazzei,2 Valeria Testugini,2 Luca Latini,1 Roberto Delle Chiaie,1 Massimo Biondi,1 Giancarlo Cianfrone21Department of Neurology and Psychiatry, Acute Psychiatric Ward (Servizio Psichiatrico di Diagnosi e Cura - SPDC, Sapienza University of Rome, Rome, Italy, 2Department of Sense Organs, Sapienza University of Rome, Rome, ItalyBackground: The connection between psychopathology and tinnitus is complex and not adequately studied. The aim of this study is to investigate the relationship between tinnitus and psychiatric comorbidities from different points of view: categorical, dimensional, temperamental, and perceived stress level.Methods: Two hundred and thirty-nine patients affected by tinnitus were recruited between January and October 2012. Patients underwent a preliminary battery of tests including the Tinnitus Handicap Inventory (THI, Symptom Check List (SCL90-R, Temperament and Character Inventory (TCI, and Stress-Related Vulnerability Scale (VRS, and eventually a full psychiatric evaluation. Results: One hundred and fourteen patients (48% of the total sample presented psychiatric comorbidity. Among these, a higher prevalence of depression, somatization, obsession, and anxiety was found. More than 41% of patients affected by decompensated tinnitus reported a family history of psychiatric disorders. Significant positive correlations between the psychopathological screening tools (SCL90-R and VRS and THI were found. Patients affected by comorbid psychiatric disorder showed specific temperamental and characterial predispositions.Conclusion: Psychiatric comorbidity in subjects affected by tinnitus is frequent. Stress can be considered as a factor leading to damage and dysfunction of the auditory apparatus. The vulnerability to neurotic disorders and

  20. PDGF-metronidazole-encapsulated nanofibrous functional layers on collagen membrane promote alveolar ridge regeneration

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    Ho MH

    2017-08-01

    Full Text Available Ming-Hua Ho,1 Hao-Chieh Chang,2,3 Yu-Chia Chang,3 Jeiannete Claudia,1 Tzu-Chiao Lin,2 Po-Chun Chang2,3 1Department of Chemical Engineering, College of Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 2Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; 3Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan Abstract: This study aimed to develop a functionally graded membrane (FGM to prevent infection and promote tissue regeneration. Poly(L-lactide-co-D,L-lactide encapsulating platelet-derived growth factor (PDLLA-PDGF or metronidazole (PDLLA-MTZ was electrospun to form a nanofibrous layer on the inner or outer surface of a clinically available collagen membrane, respectively. The membrane was characterized for the morphology, molecule release profile, in vitro and in vivo biocompatibility, and preclinical efficiency for alveolar ridge regeneration. The PDLLA-MTZ and PDLLA-PDGF nanofibers were 800–900 nm in diameter, and the thicknesses of the functional layers were 20–30 µm, with sustained molecule release over 28 days. All of the membranes tested were compatible with cell survival in vitro and showed good tissue integration with minimal fibrous capsule formation or inflammation. Cell proliferation was especially prominent on the PDLLA-PDGF layer in vivo. On the alveolar ridge, all FGMs reduced wound dehiscence compared with the control collagen membrane, and the FGM with PDLLA-PDGF promoted osteogenesis significantly. In conclusion, the FGMs with PDLLA-PDGF and PDLLA-MTZ showed high biocompatibility and facilitated wound healing compared with conventional membrane, and the FGM with PDLLA-PDGF enhanced alveolar ridge regeneration in vivo. The design represents a beneficial modification, which may be easily adapted for future clinical use. Keywords: tissue engineering, platelet-derived growth factor, metronidazole, alveolar process

  1. DSM-5 PTSD and posttraumatic stress spectrum in Italian emergency personnel: correlations with work and social adjustment

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    Carmassi C

    2016-02-01

    Full Text Available Claudia Carmassi,1 Camilla Gesi,1 Marly Simoncini,1 Luca Favilla,1 Gabriele Massimetti,1 Maria Cristina Olivieri,1 Ciro Conversano,2 Massimo Santini,2 Liliana Dell’Osso1 1Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy; 2Emergency Medicine and Emergency Room Unit, Azienda Ospedaliero-Universitaria Pisana (AOUP, Pisa, Italy Abstract: The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5 has recently recognized a particular risk for posttraumatic stress disorder (PTSD among first responders (criterion A4, acknowledging emergency units as stressful places of employment. Little data is yet available on DSM-5 among emergency health operators. The aim of this study was to assess DSM-5 symptomatological PTSD and posttraumatic stress spectrum, as well as their impact on work and social functioning, in the emergency staff of a major university hospital in Italy. One hundred and ten subjects (doctors, nurses, and health-care assistants were recruited at the Emergency Unit of the Azienda Ospedaliero-Universitaria Pisana (Italy and assessed by the Trauma and Loss Spectrum-Self Report (TALS-SR and Work and Social Adjustment Scale (WSAS. A 15.7% DSM-5 symptomatological PTSD prevalence rate was found. Nongraduated persons reported significantly higher TALS-SR Domain IV (reaction to loss or traumatic events scores and a significantly higher proportion of individuals presenting at least one maladaptive behavior (TALS-SR Domain VII, with respect to graduate ones. Women reported significantly higher WSAS scores. Significant correlations emerged between PTSD symptoms and WSAS total scores among health-care assistants, nongraduates and women. Our results showed emergency workers to be at risk for posttraumatic stress spectrum and related work and social impairment, particularly among women and nongraduated subjects. Keywords: posttraumatic stress disorder (PTSD, emergency, emergency

  2. Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review

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    Gabriele Di Lorenzo

    2008-12-01

    Full Text Available Gabriele Di Lorenzo1, Alberto D’Alcamo1, Manfredi Rizzo1, Maria Stefania Leto-Barone1, Claudia Lo Bianco1, Vito Ditta1, Donatella Politi1, Francesco Castello1, Ilenia Pepe1, Gaetana Di Fede2, GiovamBattista Rini11Dipartimento di Medicina clinica e delle Patologie Emergenti; 2Dipartimento di Discipline Chirurgiche ed Oncologiche, Università degli Studi di Palermo, ItalyAbstract: In vitro and in vivo clinical and experimental data have suggested that leukotrienes play a key role in inflammatory reactions of the skin. Antileukotriene drugs, ie, leukotriene receptor antagonists and synthesis inhibitors, are a class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma and in rhinitis with asthma. We searched MEDLINE database and carried out a manual search on journals specializing in allergy and dermatology for the use of antileukotriene drugs in urticaria. Montelukast might be effective in chronic urticaria associated with aspirin (ASA or food additive hypersensitivity or with autoreactivity to intradermal serum injection (ASST when taken with an antihistamine but not in mild or moderate chronic idiopathic urticaria [urticaria without any possible secondary causes (ie, food additive or ASA and other NSAID hypersensitivity, or ASST]. Evidence for the effectiveness of zafirlukast and the 5-lipoxygenase inhibitor, zileuton, in chronic urticaria is mainly anecdotal. In addition, there is anecdotal evidence of effectiveness of antileukotrienes in primary cold urticaria, delayed pressure urticaria and dermographism. No evidence exists for other physical urticarias, including cholinergic, solar and aquagenic urticarias, vibratory angioedema, and exercise-induced anaphylaxis.Keywords: chronic idiopathic urticaria, leukotriene receptor antagonists, montelukast, zafirlukast, antihistamine

  3. S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis

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    Mazo DF

    2013-06-01

    Full Text Available Daniel FC Mazo,1 Marcelo G de Oliveira,2 Isabel VA Pereira,1 Bruno Cogliati,3 José T Stefano,1 Gabriela FP de Souza,2 Fabíola Rabelo,1 Fabiana R Lima,4 Venâncio A Ferreira Alves,4 Flair J Carrilho,1 Claudia PMS de Oliveira1 1University of São Paulo School of Medicine, Department of Gastroenterology, Clinical Division, Hepatology Branch (LIM-07, Sao Paulo, Brazil; 2Institute of Chemistry, University of Campinas, Campinas, Sao Paulo, Brazil; 3University of Sao Paulo School of Veterinary Medicine and Animal Science, Department of Pathology, Sao Paulo, Brazil; 4University of São Paulo School of Medicine, Department of Pathology (LIM14, São Paulo, Brazil Abstract: S-Nitroso-N-acetylcysteine (SNAC is a water soluble primary S-nitrosothiol capable of transferring and releasing nitric oxide and inducing several biochemical activities, including modulation of hepatic stellate cell activation. In this study, we evaluated the antifibrotic activity of SNAC in an animal model of nonalcoholic steatohepatitis (NASH induced in Sprague-Dawley rats fed with a choline-deficient, high trans fat diet and exposed to diethylnitrosamine for 8 weeks. The rats were divided into three groups: SNAC, which received oral SNAC solution daily; NASH, which received the vehicle; and control, which received standard diet and vehicle. Genes related to fibrosis (matrix metalloproteinases [MMP]-13, -9, and -2, transforming growth factor ß-1 [TGFß-1], collagen-1a, and tissue inhibitors of metalloproteinase [TIMP-1 and -2] and oxidative stress (heat-shock proteins [HSP]-60 and -90 were evaluated. SNAC led to a 34.4% reduction in the collagen occupied area associated with upregulation of MMP-13 and -9 and downregulation of HSP-60, TIMP-2, TGFß-1, and collagen-1α. These results indicate that oral SNAC administration may represent a potential antifibrotic treatment for NASH. Keywords: nitric oxide, S-nitroso-N-acetylcysteine, fibrogenesis, NASH, diethylnitrosamine

  4. O índio na fotografia brasileira: incursões sobre a imagem e o meio The Indian in Brazilian photography: incursions into image and medium

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    Fernando de Tacca

    2011-03-01

    Full Text Available Pretende-se explorar contradições e confluências entre o meio (fotográfico e a imagem do índio brasileiro sob uma perspectiva histórica da fotografia brasileira. A imagem do índio nessa fotografia manifesta-se em três momentos distintos. Na fase inicial, no lugar do exótico, contraditório ao sentido moderno da fotografia durante o Segundo Império. Na segunda fase, as fronteiras entre o etnográfico e o nacional se diluem, nos primeiros cinquenta anos do século XX, a exemplo da Comissão Rondon/Seção de Estudos do SPI e do fotojornalismo moderno no Brasil da revista O Cruzeiro. No terceiro momento, as manifestações de uma etnopoética das fotografias de Claudia Andujar fazem meio e imagem se fundirem como lugar etnográfico na arte contemporânea.The article explores contradictions and convergences between a medium (photography and the image of the Brazilian Indian from the perspective of the history of Brazilian photography. During the first of three distinct moments, the image of the Indian was of someone exotic, in contradiction with the modern meaning of photography under the Second Empire. During the second moment, in the first fifty years of the twentieth century, the boundaries between ethnography and Brazil as a nation were blurred, as exemplified by the Rondon Commission/Indian Protection Bureau's Research Section (Serviço de Proteção ao Índio and Brazil's modern photojournalism, as found in the magazine Cruzeiro. During the third moment, the expressions of an ethno-poetry present in the photographs of Cláudia Andujar can be seen to blend medium and image as an ethnographic space in contemporary art.

  5. New developments in the management of relapsed/refractory multiple myeloma – the role of ixazomib

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    Richardson PG

    2017-08-01

    Full Text Available Paul G Richardson,1 Shaji Kumar,2 Jacob P Laubach,1 Claudia Paba-Prada,1 Neeraj Gupta,3 Deborah Berg,3 Helgi van de Velde,3 Philippe Moreau4 1Division of Hematologic Malignancy, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA, USA; 2Division of Hematology, Mayo Clinic, Rochester, MN, USA; 3Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA; 4Hematology Department, University Hospital Hotel-Dieu, Nantes, France Abstract: Ixazomib is the first oral proteasome inhibitor to be approved, in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was on the basis of results from the phase 3, double-blind, placebo-controlled TOURMALINE-MM1 study, which demonstrated a 35% improvement in progression-free survival with the all-oral combination of ixazomib plus lenalidomide–dexamethasone versus lenalidomide–dexamethasone alone (median: 20.6 vs 14.7 months; hazard ratio: 0.74, p=0.012; median follow-up 14.7 months. The addition of ixazomib to the lenalidomide–dexamethasone regimen was associated with limited additional toxicity and had no adverse impact on patient-reported quality of life. Common grade ≥3 adverse events with ixazomib include gastrointestinal adverse events, rash, and thrombocytopenia. Here, we review the efficacy, safety, pharmacokinetics, and patient-reported quality of life data seen with ixazomib, and discuss the role of this oral agent in the treatment of patients with relapsed/refractory multiple myeloma, including in patients with high-risk cytogenetic abnormalities and those with multiple prior therapies. Keywords: ixazomib, multiple myeloma, proteasome inhibitor, clinical, efficacy, tolerability, pharmacokinetics 

  6. Editorial

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    Salomón Kalmanovitz

    2015-06-01

    Full Text Available En este segundo número de tiempo&economía presentamos dos ensayos sobre temas fiscales en diferentes períodos y regiones. Salomón Kalmanovitz alarga su análisis sobre las cuentas fiscales del Estado Soberano de Panamá (Revista de Economía Institucional, No 27, 2012 a la nueva nación que surge de su separación de Colombia, auspiciada no sólo por el imperio norteamericano sino resentida por el maltrato que recibió del centro político colombiano. Su aporte es mirar con detenimiento las cuentas fiscales de Panamá en medio de un difícil proceso de construcción de Estado sin contar con el monopolio de los medios de violencia y sin disponer de su territorio más valioso. Junto con Giuseppe De Corso se estima el PIB de Panamá entre 1906 y 1945, que es el primer intento que se hace en este sentido y permite completar la serie que la Cepal hizo desde 1945 para todo el siglo XX. Claudia Chaves, por su parte, examina los conflictos fronterizos entre las provincias de Minas Gerais y Sao Paolo entre 1780 y 1815 en torno a la jurisdicción y administración financiera con el cambio que significó pasar de las juntas de hacienda real del Brasil colonial, a la creación del Erario Real del Imperio Portugués que se trasladó al Brasil tras la invasión de Napoleón a la península ibérica.

  7. Development of a Healthy Lifestyle Mobile App for Overweight Pregnant Women: Qualitative Study.

    Science.gov (United States)

    Lau, Ying; Cheng, Ling Jie; Chi, Claudia; Tsai, Cammy; Ong, Kai Wen; Ho-Lim, Sarah Su Tin; Wang, Wei; Tan, Kian-Lee

    2018-04-23

    Mobile apps are becoming an increasingly ubiquitous platform for delivery of health behavior interventions among overweight and obese perinatal women. However, only a few methodological guidelines on integrating theory, evidence, and qualitative research for their designs are available. The aim of this study was to develop a theory-based, evidence-driven, and user-centered healthy lifestyle app targeting overweight and obese multiethnic pregnant women. This paper illustrates how intervention development may be enriched with theoretical basis, systematic review, and qualitative study. An individual face-to-face interview was performed to incorporate the user's involvement in the design. These interviews were audiotaped and transcribed. Thematic analysis technique was used for emerging themes. Integrated concepts of social cognitive theory of self-regulation, self-regulation model, and strength model of self-control were selected as bases of the intervention. Evidence from our systematic review and meta-analysis provided the strongest evidence for the development of intervention. We invited 16 obese or overweight pregnant women to participate in a semistructured interview . The following key themes emerged: content, platform, interactivity, format, and functionality. Apps are a favorable technology platform for healthy diet advice, appropriate physical exercise, and weight management because they are user-friendly and convenient. The app used in this study contains culture-specific, pregnancy-related, and credible contents, including educational, professional and peer support, and self-monitoring domains. The design should include aesthetic appeal, visualized features, and interactive multimedia. A 3-step process integrating theoretical basis, evidence from systematic review, and research findings from target users can be considered a guide for future app development. ©Ying Lau, Ling Jie Cheng, Claudia Chi, Cammy Tsai, Kai Wen Ong, Sarah Su Tin Ho-Lim, Wei Wang

  8. Innovative treatments for severe refractory asthma: how to choose the right option for the right patient?

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    Menzella F

    2017-08-01

    Full Text Available Francesco Menzella,1 Carla Galeone,1 Francesca Bertolini,2 Claudia Castagnetti,1 Nicola Facciolongo1 1Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 2Department of Animal Science, Iowa State University, Ames, IA, USA Abstract: The increasing understanding of the molecular biology and the etiopathogenetic mechanisms of asthma helps in identification of numerous phenotypes and endotypes, particularly for severe refractory asthma. For a decade, the only available biologic therapy that met the unmet needs of a specific group of patients with severe uncontrolled allergic asthma has been omalizumab. Recently, new biologic therapies with different mechanisms of action and targets have been approved for marketing, such as mepolizumab. Other promising drugs will be available in the coming years, such as reslizumab, benralizumab, dupilumab and lebrikizumab. Moreover, since 2010, bronchial thermoplasty has been successfully introduced for a limited number of patients. This is a nonpharmacologic endoscopic procedure which is considered a promising therapy, even though several aspects still need to be clarified. Despite the increasing availability of new therapies, one of the major problems of each treatment is still the identification of the most suitable patients. This sudden abundance of therapeutic options, sometimes partially overlapping with each other, increases the importance to identify new biomarkers useful to guide the clinician in selecting the most appropriate patients and treatments, without forgetting the drug-economic aspects seen in elevated direct cost of new therapies. The aim of this review is, therefore, to update the clinician on the state of the art of therapies available for refractory asthma and, above all, to give useful directions that will help understand the different choices that sometimes partially overlap and to dispel the possible doubts that still exist

  9. オースティン作品の女友達:Northanger Abbey を中心に

    OpenAIRE

    ブラウン馬本, 鈴子

    2017-01-01

    フェミニズムでは、女友達の存在は、女性が自立を図る上で重要であると考えられている。作家ジェイン・オースティンの作品では女性同士の“ real friendship”は存在するのであろうか。本稿では初期の作品であるNorthanger Abbey(1818)の女主人公Catherine Morland とその友人Isabella Thorpe やTilney 兄妹との友情を中心に、オースティン作品の中で女友達を登場させる意義の解読を試みた。Isabella との浅はかな友情を通して、彼女の狡猾で浮気性な本性が露呈されると同時に、主人公の〈単純〉〈純粋〉〈未熟〉な性格が強調される現象を確認した。また精読によってIsabella の友情の動機が、Catherine を利用して結婚相手を獲得することであることを明らかにした。やがてCatherineの友情は、IsabellaからTilney兄妹へと舵を切るが、Claudia L. Johnsonの指摘“ The band of good friends is all related by marriage in the end”にあるよう...

  10. Neoadjuvant treatments in triple-negative breast cancer patients: where we are now and where we are going

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    Omarini C

    2018-01-01

    Full Text Available Claudia Omarini, Giorgia Guaitoli, Stefania Pipitone, Luca Moscetti, Laura Cortesi, Stefano Cascinu, Federico Piacentini Department of Medical and Surgical Sciences for Children & Adults, Division of Medical Oncology, University Hospital of Modena, Modena, Italy Abstract: Triple-negative breast cancer (TNBC remains the poorest-prognosis breast cancer (BC subtype. Gene expression profiling has identified at least six different triple-negative subtypes with different biology and sensitivity to therapies. The heterogeneous nature of TN tumors may justify the difficulty in treating this BC subtype. Several targeted agents have been investigated in clinical trials without demonstrating a clear survival benefit. Therefore, systemic chemotherapy remains the cornerstone of current clinical practice. Improving the knowledge of tumor biology is mandatory for patient management. In stages II and III, neoadjuvant systemic treatment is an effective option of care. The achievement of a pathological complete response represents an optimal surrogate for survival outcome as well as a test for tumor drug sensitivity. In this review, we provide a brief description of the main predictive biomarkers for tumor response to systemic treatment. Moreover, we review the treatment strategies investigated for TNBCs in neoadjuvant settings focusing on experimental drugs such as immunotherapy and poly [ADP-ribose] polymerase inhibitors that hold promise in the treatment of this aggressive disease. Therefore, the management of TNBC represents an urgent, current, unmet need in daily clinical practice. A key recommendation is to design biology-driven clinical trials wherein TNBC patients may be treated on the basis of tumor molecular profile. Keywords: triple-negative breast cancer, neoadjuvant chemotherapy, BRCA, platinum, immunotherapy, PARP-1 inhibitors

  11. User Acceptance of Computerized Cognitive Behavioral Therapy for Depression: Systematic Review.

    Science.gov (United States)

    Rost, Theresia; Stein, Janine; Löbner, Margrit; Kersting, Anette; Luck-Sikorski, Claudia; Riedel-Heller, Steffi G

    2017-09-13

    Computerized cognitive behavioral therapy (cCBT) has been proven to be effective in depression care. Moreover, cCBT packages are becoming increasingly popular. A central aspect concerning the take-up and success of any treatment is its user acceptance. The aim of this study was to update and expand on earlier work on user acceptance of cCBT for depression. This paper systematically reviewed quantitative and qualitative studies regarding the user acceptance of cCBT for depression. The initial search was conducted in January 2016 and involved the following databases: Web of Science, PubMed, the Cochrane Library, and PsycINFO. Studies were retained if they described the explicit examination of the user acceptance, experiences, or satisfaction related to a cCBT intervention, if they reported depression as a primary outcome, and if they were published in German or English from July 2007 onward. A total of 1736 studies were identified, of which 29 studies were eligible for review. User acceptance was operationalized and analyzed very heterogeneously. Eight studies reported a very high level of acceptance, 17 indicated a high level of acceptance, and one study showed a moderate level of acceptance. Two qualitative studies considered the positive and negative aspects concerning the user acceptance of cCBT. However, a substantial proportion of reviewed studies revealed several methodical shortcomings. In general, people experience cCBT for depression as predominantly positive, which supports the potential role of these innovative treatments. However, methodological challenges do exist in terms of defining user acceptance, clear operationalization of concepts, and measurement. ©Theresia Rost, Janine Stein, Margrit Löbner, Anette Kersting, Claudia Luck-Sikorski, Steffi G Riedel-Heller. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.09.2017.

  12. Architettura e arte pubblica in Italia dopo il 1945. About and Context

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    Paola Valenti

    2017-05-01

    - Lisa Parola, storica dell’arte, curatrice, membro dell’Associazione culturale a.titolo, Arte e sfera pubblica: l’esperienza di Nuovi Committenti in Italia. - Cesare Viel, artista, docente presso l’Accademia Ligustica di Belle Arti di Genova, Spazi di pubblica riflessione. I mutevoli confini della relazione tra intimo e collettivo, provvisorio e durevole, latente e manifesto nella pratica artistica contemporanea. Al fine di restituire la complessità dei temi affrontati e la ricchezza del dibattito che ha accompagnato le relazioni, per il numero della rivista “on the w@terfront” si è deciso di operare una selezione degli interventi presentati al convegno riferiti al contesto italiano (Claudia Collina, Alessandra Barbuto, Lisa Parola, Cesare Viel e di integrarla con alcuni saggi, affidati ai giovani studiosi che hanno collaborato alla redazione del volume Arte negli edifici pubblici. L’applicazione della “legge del 2%” in Liguria dal 1949 ad oggi, che illustrano la metodologia seguita nell’ambito della ricerca sulla applicazione della legge del 2% in Liguria (Rocco Spigno, che presentano i più importanti interventi e progetti culturali che hanno interessato la città di Genova dal 1992, anno dell’Esposizione Colombiana che ha segnato una inversione di rotta per il capoluogo ligure, ad oggi (Alessandra Piatti, che riflettono su come l’arte pubblica abbia trovato, in Italia, un terreno di controcultura nel World Wide Web (Francesca Bulian. Il contributo di Paola Valenti, che apre la raccolta di saggi, si propone di presentare al lettore la realtà del capoluogo ligure da un punto di vista storico, architettonico, urbanistico e culturale, evidenziando soprattutto la sua peculiare condizione di città policentrica e in costante evoluzione.

  13. Rosetta at Perihelion: The Journey Continues

    Science.gov (United States)

    Weissman, Paul R.; Taylor, Matthew; Alexander, Claudia J.

    2015-11-01

    ESA’s Rosetta spacecraft, with participation by NASA, has been in orbit around the nucleus of comet 67P/Churyumov-Gerasimenko for over one year. It has been a year of great discoveries and accomplishments, including the first successful spacecraft landing on the surface of a cometary nucleus (and the second and the third landings). The discoveries include 1) the unusual shape of the bi-lobed nucleus, 2) the substantial change of the nucleus rotation period (which continues to evolve), 3) the high dust-to-gas ratio, 4 ± 1 (by mass), 4) the low bulk density of the nucleus, 0.50 g/cm3, 5) the high deuterium/hydrogen ratio of the coma water molecules, 5.3 x 10-4, more than 3 times the terrestrial value, 6) the highly complex and different terrains on the nucleus surface, 7) the lack of any intrinsic magnetic field, 8) the existence of cylindrical pits in the nucleus surface, typically ~200 m in diameter and ~180 m deep, 9) the existence of “goose bump” terrain, which may provide clues to the accretion of the comet nucleus, 10) the existence of many similarly-sized boulders on the nucleus surface, and much more. The spacecraft and comet passed through perihelion on August 13, 2015, which has been marked by substantial, volatile-rich outbursts from the cometary nucleus. The Rosetta mission has now been extended to September, 2016, when the comet and spacecraft will be approaching 4 AU, outbound from the Sun. This talk is dedicated to the memory of Dr. Claudia J. Alexander, U.S. Rosetta Project Scientist, who passed away in July of this year. Her tireless efforts and tremendous enthusiasm on behalf of Rosetta contributed greatly to the success of the mission.

  14. Bevacizumab treatment in the elderly patient with metastatic colorectal cancer

    Directory of Open Access Journals (Sweden)

    Di Bartolomeo M

    2015-01-01

    Full Text Available Maria Di Bartolomeo,1 Claudia Maggi,1 Francesca Ricchini,1 Filippo Pietrantonio,1 Roberto Iacovelli,1 Filippo de Braud,1 Alessandro Inno2 1Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 2Department of Medical Oncology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy Abstract: Metastatic colorectal cancer (mCRC, like many cancers, is primarily a disease of elderly people. Despite this prevalence, such patients are often excluded from randomized trials or represent a minority of enrolled patients. Moreover, the criteria for establishing benefit or side effects of treatment strategies in this population are uncertain and not well recognized. Bevacizumab improves the outcome of mCRC when used in combination with standard first-line and second-line chemotherapy and beyond the first disease progression when given with a chemotherapy backbone different from that used in the precedent line. The particular toxicity profile of this antiangiogenesis agent (in particular hypertension, thromboembolic events, hemorrhage, and renal failure may discourage its use in elderly patients with comorbidities. Data from subgroup analyses of randomized trials and the results of recent cohort studies suggest a significant benefit from the addition of bevacizumab to standard chemotherapy for elderly patients comparable with that observed in younger patients, except for the increased risk for thromboembolic events. Age alone should not be a barrier to use of bevacizumab, and further research with a more complete geriatric assessment should investigate the role of bevacizumab in elderly patients with mCRC to avoid undertreatment of this patient population due to a ­historical conservative approach. Keywords: bevacizumab, elderly, metastatic colorectal cancer, antivascular treatment, review

  15. ENSI Approach to Oversight of Safety Culture

    International Nuclear Information System (INIS)

    Humbel Haag, Claudia

    2012-01-01

    Claudia Humbel Haag presented developments in ENSI approach to safety culture oversight. ENSI has developed a definition/understanding of Safety Culture and a concept of how to perform oversight of Safety Culture. ENSI defines safety culture in the following way: Safety Culture comprises the behaviour, world views (in the sense of conceptualisations of reality and explanation models), values (in the sense of aims and evaluation scales), and features of the physical environment (specifically, the nuclear power plant and the documents used) which are shared by many members of an organization, in as much as these are of significance to nuclear safety. A model of the accessibility of safety culture was presented ranging from the observable (external aspects of safety culture), to aspects that are accessible by asking questions, through to aspects that are not accessible (internal part of safety culture). ENSI considers observable aspects through the existing systematic safety assessment compliance program. Aspects that are observable by asking questions will be addressed by additional oversight activities outside the systematic assessment program. Aspects that are not accessible are addressed by helping the licensee to re-think its safety culture through proactive discussions on safety culture. Reports are issued to the licensee on assumptions and observations identified through the discussions. The conclusions of the presentation emphasised the importance of basing any interventions in this area on a solid understanding of the concept of safety culture. ENSI safety culture oversight principles were also described. These include licensee responsibility for safety, and the need for the regulator to critically review their own activities to ensure a positive influence on the licensee

  16. Targeted treatments for cervical cancer: a review

    Directory of Open Access Journals (Sweden)

    Peralta-Zaragoza O

    2012-11-01

    Full Text Available Oscar Peralta-Zaragoza,1 Víctor Hugo Bermúdez-Morales,1 Carlos Pérez-Plasencia,2,3 Jonathan Salazar-León,1 Claudia Gómez-Cerón,1 Vicente Madrid-Marina11Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Cuernavaca, Morelos, México; 2Oncogenomics Laboratory, National Cancer Institute of Mexico, Tlalpan, México; 3Biomedicine Unit, FES-Iztacala UNAM, México City, MéxicoAbstract: Cervical cancer is the second most common cause of cancer death in women worldwide and the development of new diagnosis, prognostic, and treatment strategies merits special attention. Although surgery and chemoradiotherapy can cure 80%–95% of women with early stage cancer, the recurrent and metastatic disease remains a major cause of cancer death. Many efforts have been made to design new drugs and develop gene therapies to treat cervical cancer. In recent decades, research on treatment strategies has proposed several options, including the role of HPV E6 and E7 oncogenes, which are retained and expressed in most cervical cancers and whose respective oncoproteins are critical to the induction and maintenance of the malignant phenotype. Other efforts have been focused on antitumor immunotherapy strategies. It is known that during the development of cervical cancer, a cascade of abnormal events is induced, including disruption of cellular cycle control, perturbation of antitumor immune response, alteration of gene expression, and deregulation of microRNA expression. Thus, in this review article we discuss potential targets for the treatment of cervical cancer associated with HPV infection, with special attention to immunotherapy approaches, clinical trials, siRNA molecules, and their implications as gene therapy strategies against cervical cancer development.Keywords: Cervical cancer, clinical trials, gene therapy, HPV E6 and E7 oncogenes, siRNAs

  17. An interactive modelling tool for understanding hydrological processes in lowland catchments

    Science.gov (United States)

    Brauer, Claudia; Torfs, Paul; Uijlenhoet, Remko

    2016-04-01

    Recently, we developed the Wageningen Lowland Runoff Simulator (WALRUS), a rainfall-runoff model for catchments with shallow groundwater (Brauer et al., 2014ab). WALRUS explicitly simulates processes which are important in lowland catchments, such as feedbacks between saturated and unsaturated zone and between groundwater and surface water. WALRUS has a simple model structure and few parameters with physical connotations. Some default functions (which can be changed easily for research purposes) are implemented to facilitate application by practitioners and students. The effect of water management on hydrological variables can be simulated explicitly. The model description and applications are published in open access journals (Brauer et al, 2014). The open source code (provided as R package) and manual can be downloaded freely (www.github.com/ClaudiaBrauer/WALRUS). We organised a short course for Dutch water managers and consultants to become acquainted with WALRUS. We are now adapting this course as a stand-alone tutorial suitable for a varied, international audience. In addition, simple models can aid teachers to explain hydrological principles effectively. We used WALRUS to generate examples for simple interactive tools, which we will present at the EGU General Assembly. C.C. Brauer, A.J. Teuling, P.J.J.F. Torfs, R. Uijlenhoet (2014a): The Wageningen Lowland Runoff Simulator (WALRUS): a lumped rainfall-runoff model for catchments with shallow groundwater, Geosci. Model Dev., 7, 2313-2332. C.C. Brauer, P.J.J.F. Torfs, A.J. Teuling, R. Uijlenhoet (2014b): The Wageningen Lowland Runoff Simulator (WALRUS): application to the Hupsel Brook catchment and Cabauw polder, Hydrol. Earth Syst. Sci., 18, 4007-4028.

  18. Courage as a skill.

    Science.gov (United States)

    Reardon, Kathleen K

    2007-01-01

    A division vice president blows the whistle on corruption at the highest levels of his company. A young manager refuses to work on her boss's pet project because she fears it will discredit the organization. A CEO urges his board, despite push back from powerful, hostile members, to invest in environmentally sustainable technology. What is behind such high-risk, often courageous acts? Courage in business, the author has found, seldom resembles the heroic impulsiveness that sometimes surfaces in life-or-death situations. Rather, it is a special kind of calculated risk taking, learned and refined over time. Taking an intelligent gamble requires an understanding of what she calls the "courage calculation": six discrete decision-making processes that make success more likely while averting rash or unproductive behavior. These include setting attainable goals, tipping the power balance in your favor, weighing risks against benefits, and developing contingency plans. Goals may be organizational or personal. Tania Modic had both types in mind when, as a young bank manager, she overstepped her role by traveling to NewYork--on vacation time and on her own money--to revitalize some accounts that her senior colleagues had allowed to languish. Her high-risk maneuver benefited the bank and gained her a promotion. Lieutenant General Claudia J. Kennedy weighed the risks and benefits before deciding to report a fellow officer who had plagiarized a research paper at a professional army school. In her difficult courage calculation, loyalty to army standards proved stronger than the potential discomfort and embarrassment of "snitching" on a fellow officer. When the skills behind courageous decision making align with a personal, organizational, or societal philosophy, managers are empowered to make bold moves that lead to success for their companies and their careers.

  19. O gigante adormecido vem pra rua: construções enunciativas de Johnnie Walker e Fiat durante as manifestações brasileiras de 2013

    Directory of Open Access Journals (Sweden)

    Carolina Fernandes da Silva Mandaji

    2014-04-01

    Full Text Available O tema deste trabalho são as manifestações ocorridas nos meses de junho e julho de 2013 em todo o Brasil. Trata-se de uma reflexão sobre as construções enunciativas de discursos midiáticos no cenário nacional e internacional.  Esta investigação se propõe a entender os processos enunciativos, e portanto, discursivos e interacionais no uso da materialidade sincrética e audiovisual de anúncios publicitários das marcas Johnnie Walker e Fiat. Tanto a campanha “Keep walking, Brazil” como  a “Vem pra rua” da Fiat foram (re contextualizadas em outros processos enunciativos durante as manifestações brasileiras. Será possível identificar que tipo de interação discursiva ocorre entre marcas e público a partir de tal (re contextualização? Qual relação enunciativa existe entre as marcas e as manifestações e quais são os papeis enunciativos e discursivos propostos por tal relação?  Tais perguntas irão nos levar ao contexto de produção das campanhas, mas também a uma nova apreensão de sentido pautada por processos enunciativos que não os das próprias marcas, mas sim, de novas posições enunciativas. A base metodológica guia-se pelos estudos da Semiótica Discursiva de A. J. Greimas e pelos pressupostos teóricos da Sociossemiótica proposto por Eric Landowski e nas pesquisas de Ana Claudia de Oliveira.

  20. Acute exacerbated COPD: room for improvement in key elements of care

    Directory of Open Access Journals (Sweden)

    Markun S

    2017-10-01

    Full Text Available Stefan Markun,1,* Daniel P Franzen,2,* Kaba Dalla Lana,1 Swantje Beyer,3 Stephan Wieser,4 Thomas Hess,3 Malcolm Kohler,2 Thomas Rosemann,1 Oliver Senn,1 Claudia Steurer-Stey1,5 1Institute of Primary Care, 2Department of Pneumology, University Hospital Zurich, University of Zurich, Zurich, 3Department of Pneumology, Cantonal Hospital of Winterthur, Winterthur, 4Department of Pneumology, City Hospital Waid, 5MediX Group Practice Ltd, Zurich, Switzerland *These authors contributed equally to this work Introduction: Hospitalizations because of acute exacerbated COPD (AECOPD are a major burden to patients and the health care system. Interventions during acute and post-acute hospital care exist not only to improve short-term outcomes but also to prevent future exacerbations and disease progression. We aimed at measuring the implementation rates of acute and post-acute hospital care interventions for AECOPD.Methods: We performed 24 months (January 1, 2012, to December 31, 2013 retrospective medical chart review of consecutive cases hospitalized to one of three public hospitals in the canton of Zurich due to AECOPD. Implementation rates of five acute care and seven post-acute care interventions were assessed.Results: Data from 263 hospitalizations (61% male, mean age 68.5 years, 47% active smokers were analyzed. The median length of stay was 9 days (interquartile range [IQR] 6–12 days. In all, 32% of hospitalizations were caused by individuals with previous hospitalizations because of AECOPD. Implementation rates of four acute care interventions were >75% (lowest was appropriate antibiotic therapy with 56%. Compared to this, implementation rates of five post-acute care interventions were <25% (lowest was patient education and self-management advice with 2%.Conclusion: The results of this audit revealed room for improvement mainly in post-acute care interventions for AECOPD. Keywords: audit, COPD, exacerbation, guideline adherence, hospital

  1. Tolerability and camouflaging effect of corrective make-up for acne: results of a clinical study of a novel face compact cream

    Directory of Open Access Journals (Sweden)

    Monfrecola G

    2016-10-01

    Full Text Available Giuseppe Monfrecola, Sara Cacciapuoti, Claudia Capasso, Mario Delfino, Gabriella Fabbrocini Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy Background: A novel face compact cream (FCC containing a new patented formulation was recently developed to provide acne patients with cosmetic camouflage for their lesions and to have beneficial effects on the multifactorial components of the disease. This pilot investigation aimed to evaluate the real-life tolerability, potential for comedogenicity and covering effect provided by this FCC.Methods: This single-center study evaluated the FCC applied once daily for 28 days in 20 females with facial acne. Tolerability was assessed by rating skin reactions on a scale from 1 =absent to 4 =evident. Comedogenicity potential was evaluated by determining the number of facial acne lesions before and after use of the FCC. The covering effect was rated in ten patients 30 minutes after application on a scale from 1 =none to 5 =excellent. Patients rated their opinions on the FCC on day 28 using a questionnaire.Results: Assessment of tolerability on days 0, 14, and 28 showed that skin reactions, including erythema, edema, dryness, desquamation, tight feeling, itching, and burning, were absent in all patients. The FCC was noncomedogenic and provided a significant 15.8% reduction in facial acne lesions after 28 days (P<0.001. The FCC provided a good covering effect 30 minutes after application in 80% of patients. All patients (100% were satisfied with the FCC, with 90% agreeing that the FCC was effective and 80% stating that the FCC improved their skin.Conclusion: The FCC was positively perceived, well tolerated, noncomedogenic, and provided an effective covering of acne in this small group of female patients with 1 month of follow-up. Keywords: acne, comedones, dermatocosmetic, tolerability

  2. Randomized controlled trial of a water-soluble nail lacquer based on hydroxypropyl-chitosan (HPCH, in the management of nail psoriasis

    Directory of Open Access Journals (Sweden)

    Cantoresi F

    2014-05-01

    Full Text Available Franca Cantoresi,1 Maurizio Caserini,2 Antonella Bidoli,1 Francesca Maggio,1 Raffaella Marino,1 Claudia Carnevale,1 Paola Sorgi,1 Renata Palmieri21Department of Dermatology, Sapienza University, Rome, Italy; 2Scientific Department, Polichem SA, Lugano, Switzerland Background: Nail psoriasis occurs in up to 50% of patients affected by psoriasis, with a significant impact on quality of life that leads to a real clinical need for new therapeutic options. Aim: To confirm whether the strengthening and hardening properties of the hydroxypropyl-chitosan (HPCH nail lacquer could improve the structure of the nail plates on psoriatic nails. Materials and methods: A randomized, double-blind, placebo controlled, parallel-group trial was carried out to evaluate the efficacy and tolerability of a hydrosoluble nail lacquer containing HPCH, Equisetum arvense, and methylsulfonylmethane on nail psoriasis. The test product or a placebo was applied once daily for 24 weeks to all fingernails. Efficacy assessments were performed on the target fingernail by means of the modified Nail Psoriasis Severity Index score. A cut-off score of 4 was considered to define the clinical cure rate (ie, Cure ≤4, Failure >4. Results: After 24 weeks, the clinical cure rate showed the statistically significant superiority of the HPCH nail lacquer compared to placebo in both the intention-to-treat (Fisher's exact test, P=0.0445 and the per protocol population (Fisher's exact test, P=0.0437. This superiority was already present after 16 weeks of treatment. Moreover, the analysis of the modified Nail Psoriasis Severity Index-50 showed a statistically significant clinical improvement after 12 weeks of treatment in comparison to the results obtained after 8 weeks (Fisher's exact test, P<0.05. Conclusion: The trial showed that HPCH nail lacquer could be a new, valid, effective, and safe option for decreasing the signs of nail dystrophy in psoriatic patients. Keywords: nail psoriasis

  3. Romanian Association of Balneology Conference – 2015, 28 – 31 May, Băile Tuşnad

    Directory of Open Access Journals (Sweden)

    MUNTEANU Constantin

    2015-05-01

    Full Text Available 1.\tProf. Onose G, MD, PhD, MSc, Univ. Assist. Haras MA, MD, PhD, Prof. Sinescu CJ, MD, PhD1,2, Univ. Assist. Daia CO, MD, PhD1,2, RDI Assist. Andone I, MD, Postgrad2, Onose VL, MD,3, Assist. Prof. Capisizu A, MD, PhD1,4, Prof. Grigorean VT, MD, PhD1,2, Assoc. Prof. Ciobotaru C, MD, PhD5,6, Sandu AM, MD, Postgrad.2, Assist. Prof. Blendea CD, MD, PhD7, 8 - BASIC WELLNESS FEATURES AND SOME RELATED ACTIONS, PROPENSIVE INCLUDING FOR ACTIVE AND HEALTHY AGEING - 2.\tOlga SURDU, T.V. SURDU, Monica SURDU - STATE OF ART of balneotherapy/thermalisme in Romania 3.\tIliuta Maria Alexandra - THE IMPORTANCE OF NUTRITION IN HEALTH PROGRAMS 4.\tDr. Dogaru Gabriela - THERAPEUTIC EFFECTS OF MINERAL WATERS IN RENAL DISEASES 5.\tVeryho N.S. - THERAPEUTIC EFFECT OF MINERAL WATER WITH DIFFERENT CONCENTRATIONS OF HUMIC ACIDS IN EXPERIMENTAL HEPATITIS INDUCED BY ACETAMINOPHEN 6.\tIoana Marian - SPA SEEN AS AN EXTENSION OF A HEALTH RESORT - A NECESSARY CONDITION FOR INTEGRATING ROMANIA IN THE LIST OF GLOBAL WELLNESS TOURISM DESTINATIONS 7.\tBilha Neli-Claudia, Bilha Stefan - THE BALNEARY TREATMENT COURSE – A BREATH OF LIFE 8.\tBilha Neli-Claudia, Bilha Stefan - WICH SALT MINE DO YOU RECOMMEND FOR SPELEOTHERAPY? Interdisciplinary project proposal. 9.\tGáspár Boróka, Gabriela Dogaru - BALNEOTHERAPY IN THE BOGHIŞ RESORT 10.\tDr. Luminita Aurelia Pasca - REHABILITATION OF ELDERLY PATIENTS WITH CARDIOVASCULAR DISEASE 11.\tDr. Luminita Aurelia Pasca, Dr. Valer Donca - GEROVITAL – PROPHYLAXIS OF AGING AND GERIATRIC TREATMENT 12.\tAndronache Cristina - IMPORTANCE OF REHABILITATION TREATMENT IN HEMOPHILIC ARTHROPATHY – A CASE REPORT 13.\tDr. Motricala Marieta, Molnar Akos - BALNEOTHERAPY IN BAILE TUSNAD 14.\tIoana Pop, Bianca Pop - MEDICAL REHABILITATION IN NEUROPATHIC PAIN 15.\tAmalia Salca¹, Nicoleta Stoica1, Gabriela Dogaru¹,² - BALNEOTHERAPY IN GONARTHROSIS 16.\tAlexandru Bogdan-Cătălin, Toşa Edith-Éva - USING PULSED SHORT WAVE (DIAPULSE COMPLEMENTARY TO

  4. PREFACE: IUPAP C20 Conference on Computational Physics (CCP 2011)

    Science.gov (United States)

    Troparevsky, Claudia; Stocks, George Malcolm

    2012-12-01

    . We are grateful to the committees that helped put the conference together, especially the local organizing committee. Particular thanks are also due to a number of ORNL staff who spent long hours with the administrative details. We are pleased to express our thanks to the conference administrator Ann Strange (ORNL/CDP) for her responsive and efficient day-to-day handling of this event, Sherry Samples, Assistant Conference Administrator (ORNL), Angie Beach and the ORNL Conference Office, and Shirley Shugart (ORNL) and Fern Stooksbury (ORNL) who created and maintained the conference website. Editors: G Malcolm Stocks (ORNL) and M Claudia Troparevsky (UT) http://ccp2011.ornl.gov Chair: Dr Malcolm Stocks (ORNL) Vice Chairs: Adriana Moreo (ORNL/UT) James Guberrnatis (LANL) Local Program Committee: Don Batchelor (ORNL) Jack Dongarra (UTK/ORNL) James Hack (ORNL) Robert Harrison (ORNL) Paul Kent (ORNL) Anthony Mezzacappa (ORNL) Adriana Moreo (ORNL) Witold Nazarewicz (UT) Loukas Petridis (ORNL) David Schultz (ORNL) Bill Shelton (ORNL) Claudia Troparevsky (ORNL) Mina Yoon (ORNL) International Advisory Board Members: Joan Adler (Israel Institute of Technology, Israel) Constantia Alexandrou (University of Cyprus, Cyprus) Claudia Ambrosch-Draxl (University of Leoben, Austria) Amanda Barnard (CSIRO, Australia) Peter Borcherds (University of Birmingham, UK) Klaus Cappelle (UFABC, Brazil) Giovanni Ciccotti (Università degli Studi di Roma 'La Sapienza', Italy) Nithaya Chetty (University of Pretoria, South Africa) Charlotte Froese-Fischer (NIST, US) Giulia A. Galli (University of California, Davis, US) Gillian Gehring (University of Sheffield, UK) Guang-Yu Guo (National Taiwan University, Taiwan) Sharon Hammes-Schiffer (Penn State, US) Alex Hansen (Norweigan UST) Duane D. Johnson (University of Illinois at Urbana-Champaign, US) David Landau (University of Georgia, US) Joaquin Marro (University of Granada, Spain) Richard Martin (UIUC, US) Todd Martinez (Stanford University, US) Bill

  5. The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

    Directory of Open Access Journals (Sweden)

    Serra R

    2014-05-01

    Full Text Available Raffaele Serra,1,2,* Luca Gallelli,3,* Angela Conti,1 Giovanni De Caridi,4 Mafalda Massara,4 Francesco Spinelli,4 Gianluca Buffone,1 Francesco Giuseppe Caliò,5 Bruno Amato,6 Simona Ceglia,7 Giuseppe Spaziano,8 Luca Scaramuzzino,9 Alessia Giovanna Ferrarese,10 Raffaele Grande,1 Stefano de Franciscis1,2 1Interuniversity Center of Phlebolymphology (CIFL, International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy; 2Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy; 3Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy; 4Cardiovascular and Thoracic Department, University of Messina, Messina, Italy; 5Unit of Vascular Surgery, S Anna Hospital, Catanzaro, Italy; 6Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy; 7Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; 8Department of Experimental Medicine, Second University of Naples, Naples, Italy; 9University Campus BioMedico of Rome, Rome, Italy; 10Department of General Surgery, University of Turin, Turin, Italy *These authors contributed equally to this work Background: Mixed venous and arterial ulcers account for approximately 15%–30% of all venous leg ulcerations. Several studies have shown that matrix metalloproteinases (MMPs and neutrophil gelatinase-associated lipocalin (NGAL play a central role in the pathophysiology of venous and arterial diseases. Some studies have shown the efficacy of glycosaminoglycans, such as sulodexide (SDX, in treating patients with leg ulcers. The aim of this study was to evaluate clinical effects of SDX and its correlation with MMPs and NGAL expression in patients with mixed arterial and venous leg ulcers. Methods: Patients eligible for this study were of both sexes, older than 20 years, and with a

  6. Life sketch of martyred Meena, founding leader of RAWA

    Directory of Open Access Journals (Sweden)

    Friba of RAWA

    2009-04-01

    Full Text Available In questo contributo di Friba, una donna afghana membro di RAWA (The Revolutionary Association of the Women of Afghanistan, si ricostruiscono la vita e le lotte di Meena, la fondatrice dell’associazione. Fin dal 1973 Meena aveva maturato la decisione di battersi per i diritti delle donne e contro ogni forma di tirannia. Influenzata da autori come Ashraf Dihquany e da personaggi di donne resistenti come Jamila Bopasha e Giovanna d’Arco, ma soprattutto dalle resistenti afghane Malalai Maiwand e Rabia Balkhi, dal 1976 studia alla Facoltà di Legge Islamica della Università di Kabul. Nello stesso 1976 sposa un leader di un’ala clandestina di sinistra della Afghanistan Liberation Organization, che verrà imprigionato nel 1979. Nel 1977 pone le basi di RAWA, con lo scopo di dare finalmente voce alle donne afghane, di lottare per i loro diritti all’educazione, alla tutela legale, alla salute e alla libertà, liberandole dalla violenza e dalla povertà, e al tempo stesso per la democrazia, l’eguaglianza, la giustizia sociale e la laicità. Attraverso le varie fasi del calvario afghano, Meena si batte per diffondere RAWA fra le donne. La sua personalità forte e determinata le conquista molte simpatie e adesioni, ma la repressione del regime è durissima. Meena porta avanti la sua attività politica, affrontando duri sacrifici, soprattutto per le ripetute e prolungate separazioni dalla figlia. Nel 1981 fonda un giornale in Persiano e Pashtu «Payman e zan» (Messaggio della donna. Intanto Meena riceve riconoscimenti a livello internazionale e partecipa a incontri in varie città europee. Nonostante le gravi minacce rivoltele dai fondamentalisti islamici, rientra in patria, ma sarà poi costretta a rifugiarsi in Pakistan (prima a Peshawar poi a Quetta per l’intensificarsi del pericolo di essere arrestata dal regime. Anche dall’esilio Meena continua il suo lavoro per RAWA, raggiungendo importanti risultati sia nelle relazioni con

  7. Life sketch of martyred Meena, founding leader of RAWA

    Directory of Open Access Journals (Sweden)

    Friba of RAWA

    2008-12-01

    Full Text Available In questo contributo di Friba, una donna afghana membro di RAWA (The Revolutionary Association of the Women of Afghanistan, si ricostruiscono la vita e le lotte di Meena, la fondatrice dell’associazione. Fin dal 1973 Meena aveva maturato la decisione di battersi per i diritti delle donne e contro ogni forma di tirannia. Influenzata da autori come Ashraf Dihquany e da personaggi di donne resistenti come Jamila Bopasha e Giovanna d’Arco, ma soprattutto dalle resistenti afghane Malalai Maiwand e Rabia Balkhi, dal 1976 studia alla Facoltà di Legge Islamica della Università di Kabul. Nello stesso 1976 sposa un leader di un’ala clandestina di sinistra della Afghanistan Liberation Organization, che verrà imprigionato nel 1979. Nel 1977 pone le basi di RAWA, con lo scopo di dare finalmente voce alle donne afghane, di lottare per i loro diritti all’educazione, alla tutela legale, alla salute e alla libertà, liberandole dalla violenza e dalla povertà, e al tempo stesso per la democrazia, l’eguaglianza, la giustizia sociale e la laicità. Attraverso le varie fasi del calvario afghano, Meena si batte per diffondere RAWA fra le donne. La sua personalità forte e determinata le conquista molte simpatie e adesioni, ma la repressione del regime è durissima. Meena porta avanti la sua attività politica, affrontando duri sacrifici, soprattutto per le ripetute e prolungate separazioni dalla figlia. Nel 1981 fonda un giornale in Persiano e Pashtu «Payman e zan» (Messaggio della donna. Intanto Meena riceve riconoscimenti a livello internazionale e partecipa a incontri in varie città europee. Nonostante le gravi minacce rivoltele dai fondamentalisti islamici, rientra in patria, ma sarà poi costretta a rifugiarsi in Pakistan (prima a Peshawar poi a Quetta per l’intensificarsi del pericolo di essere arrestata dal regime. Anche dall’esilio Meena continua il suo lavoro per RAWA, raggiungendo importanti risultati sia nelle relazioni con altri

  8. Original article Unfulfilled parenthood in the eyes of young adults

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    Alicja Kalus

    2014-09-01

    Full Text Available Background The goal of the study was to present young adults’ perceptions of the experience of loss of a child at different stages of its prenatal development, as well as the level of declared support for couples after the loss. Participants and procedure The study used a scenario method based on the method by Claudia Lapman and Seana Dowling-Guyer (1995, translated into Polish by Joanna Szymańska (2013. One of the Berlin Social Support Scales (BSSS, Łyszczyńska, Kowalska, Mazurkiewicz, & Schwarzer, 2006 was also used. One hundred ninety two young adults (mean age = 26.76, SD = 4.64 took part in the research, mainly university students of technical subjects and humanities. Results The study showed that couples who lost their child, regardless of the stage at which it occurred (miscarriage or fetal death, were assessed more frequently as caring, loving, tender and sensitive, in comparison to couples for whom there was no mention of a child at all. Women who lost their child at a later stage (after the 22nd week of pregnancy were assessed significantly more frequently as relaxed, less lonely, calm and more self-confident than women who miscarried. The results were similar to those for women from the control scenario, where there was no mention of a child at all. In terms of declared support, the subjects declared significantly higher emotional support (expressing empathy, care, trust, intimacy, allowing for self-expression, etc. for couples who experienced the loss at a later stage of pregnancy than in the control scenario, as well as a higher level of instrumental support (providing material goods, solving difficult tasks together for couples who experienced miscarriage than the controls. Conclusions The experience of miscarriage and dealing with the loss is met with lower levels of empathy from the social environment, and, presumably, lower acceptance for grief. It seems important to sensitize people to the experiences of couples who

  9. Preferences of patients undergoing hemodialysis – results from a questionnaire-based study with 4,518 patients

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    Janssen IM

    2015-06-01

    Full Text Available Inger Miriam Janssen,1 Ansgar Gerhardus,2,3 Gero D von Gersdorff,4 Conrad August Baldamus,4 Mathias Schaller,4 Claudia Barth,5 Fueloep Scheibler6 1Department of Epidemiology and International Public Health, Bielefeld University, Bielefeld, Germany; 2Department for Health Services Research, University of Bremen, Bremen, Germany; 3Health Sciences Bremen, University of Bremen, Bremen, Germany; 4Department of Internal Medicine II, University Hospital of Cologne, Cologne, Germany; 5KfH Kuratorium fuer Dialyse und Nierentransplantation e.V., Neu-Isenburg, Germany; 6Department of Non-Drug Interventions, Institute for Quality and Efficiency in Health Care, Cologne, Germany Background: Chronic kidney disease is an increasing health problem worldwide and in its final stage (stage V can only be treated by renal replacement therapy, mostly hemodialysis. Hemodialysis has a major influence on the everyday life of patients and many patients report dissatisfaction with treatment. Little is known about which aspects of treatment are considered important by hemodialysis patients. The objective of this study was to rate the relative importance of different outcomes for hemodialysis patients and to analyze whether the relative importance differed among subgroups of patients.Patients and methods: Within the framework of a yearly questionnaire which is distributed among patients receiving hemodialysis by the largest hemodialysis provider in Germany, we assessed the relative importance of 23 outcomes as rated on a discrete visual analog scale. Descriptive statistics were used to rank the outcomes. Subgroup analyses were performed using Mann–Whitney U or Kruskal–Wallis tests.Results: Questionnaires of 4,518 hemodialysis patients were included in the analysis. The three most important outcomes were safety of treatment, health-related quality of life, and satisfaction with care. Further important outcomes were hospital stays, accompanying symptoms, hemodialysis

  10. Towards a Representation of Flexible Canopy N Stiochiometry for Land-surface Models Based on Optimality Concepts

    Science.gov (United States)

    Zaehle, S.; Caldararu, S.

    2015-12-01

    Foliar nitrogen (N) is know to acclimate to environmental conditions. One particular pertinent response is the general decline in foliar N following exposure to elevated levels of atmospheric CO2 (eCO2). Associated with reduced foliar N is an increased plant nitrogen-use efficiency, which contributes to the plants' sustained growth response to eCO2 in the absence of any counteracting litter N feedbacks. Flexible leaf N thus has important consequences for the mid- to long-term response of terrestrial ecosystems to eCO2. The current generation of land-surface models including a prognostic N cycle generally employ heuristic, and simply mass-balancing parameterisations to estimate changes in stoichiometry given altered N and carbon (C) availability. This generation generally and substantially overestimates the decline of foliar N (and thus the increase in plant nitrogen use efficiency) observed in Free Air CO2 Enrichment Experiments (FACE; Zaehle et al. 2014). In this presentation, I develop a simple, prognostic and dynamic representation of flexible foliar N for use in land-surface models by maximising the marginal gain of net assimilation with respect to the energy investment to generate foliar area and foliar N. I elucidate the underlying assumptions required to simulate the commonly observed decline in foliar N with eCO2 under different scenarios of N availability (Feng et al. 2015). References: Zaehle, Sönke, Belinda E Medlyn, Martin G De Kauwe, Anthony P Walker, Michael C Dietze, Hickler Thomas, Yiqi Luo, et al. 2014. "Evaluation of 11 Terrestrial Carbon-Nitrogen Cycle Models Against Observations From Two Temperate Free-Air CO2 Enrichment Studies." New Phytologist 202 (3): 803-22. doi:10.1111/nph.12697. Feng, Zhaozhong, Tobias RUtting, Håkan Pleijel, GORAN WALLIN, Peter B Reich, Claudia I Kammann, Paul C D Newton, Kazuhiko Kobayashi, Yunjian Luo, and Johan Uddling. 2015. "Constraints to Nitrogen Acquisition of Terrestrial Plants Under Elevated CO 2." Global

  11. Vegetation and land carbon feedbacks in the high-resolution transient Holocene simulations using the MPI Earth system model

    Science.gov (United States)

    Brovkin, Victor; Lorenz, Stephan; Raddatz, Thomas

    2017-04-01

    üger1, Roberta D'agostino1, Anne Dallmeyer1, Sabine Egerer1, Vivienne Groner1, Matthias Heinze1, Tatiana Ilyina1, Johann Jungclaus1, Thomas Kleinen1, Alexander Lemburg1, Stephan Lorenz1, Thomas Raddatz1, Hauke Schmidt1, Gerhard Schmiedl3, Bjorn Stevens1, Claudia Timmreck1, Matthew Toohey4 1Max-Planck-Institut für Meteorologie, D 2Wageningen University, NL 3CEN, Universität Hamburg, D 4GEOMAR Helmholtz Zentrum für Ozeanforschung Kiel, D

  12. Wearable cardioverter defibrillators for the prevention of sudden cardiac arrest: a health technology assessment and patient focus group study

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    Ettinger S

    2017-11-01

    Full Text Available Sabine Ettinger,1 Michal Stanak,1 Piotr Szymański,2 Claudia Wild,1 Romana Tandara Haček,3 Darija Erčević,3 Renata Grenković,3 Mirjana Huić3 1Ludwig Boltzmann Institute for Health Technology Assessment, Vienna, Austria; 2Institute of Cardiology, Warsaw, Poland; 3Department for Development, Research and Health Technology Assessment, Agency for Quality and Accreditation in Health Care and Social Welfare, Zagreb, Croatia Aim: To summarize the evidence on clinical effectiveness and safety of wearable cardioverter defibrillator (WCD therapy for primary and secondary prevention of sudden cardiac arrest in patients at risk. Methods: We performed a systematic literature search in databases including MEDLINE via OVID, Embase, the Cochrane Library, and CRD (DARE, NHS-EED, HTA. The evidence obtained was summarized according to GRADE methodology. A health technology assessment (HTA was conducted using the HTA Core Model® for rapid relative effectiveness assessment. Primary outcomes for the clinical effectiveness domain were all-cause and disease-specific mortality. Outcomes for the safety domain were adverse events (AEs and serious adverse events (SAEs. A focus group with cardiac disease patients was conducted to evaluate ethical, organizational, patient, social, and legal aspects of the WCD use. Results: No randomized- or non-randomized controlled trials were identified. Non-comparative studies (n=5 reported AEs including skin rash/itching (6%, false alarms (14%, and palpitations/light-headedness/fainting (9% and discontinuation due to comfort/lifestyle issues (16–22%, and SAEs including inappropriate shocks (0–2%, unsuccessful shocks (0–0.7%, and death (0–0.3%. The focus group results reported that experiencing a sense of security is crucial to patients and that the WCD is not considered an option for weeks or even months due to expected restrictions in living a “normal” life. Conclusion: The WCD appears to be relatively safe for short

  13. INOVAÇÕES EM ALIMENTAÇÃO: AS PERCEPÇÕES DOS CONSUMIDORES SOBRE PRODUTOS ENRIQUECIDOS E TRANSGÊNICOS RESUMO

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    Thelma Lucchese Cheung

    2015-12-01

    Full Text Available Logo do cabeçalho da página AJUDA DO SISTEMA USUÁRIO Logado como: elvis MEUS PERIÓDICOS PERFIL SAIR DO SISTEMA CONTEÚDO DA REVISTA Pesquisa Escopo da Busca Pesquisar Procurar POR EDIÇÃO POR AUTOR POR TÍTULO OUTRAS REVISTAS TAMANHO DE FONTE MAKE FONT SIZE SMALLERMAKE FONT SIZE DEFAULTMAKE FONT SIZE LARGER INFORMAÇÕES PARA LEITORES PARA AUTORES PARA BIBLIOTECÁRIOS OPEN JOURNAL SYSTEMS CAPA SOBRE PÁGINA DO USUÁRIO PESQUISA ATUAL ANTERIORES NOTÍCIAS MESTRADO EM DESENVOLVIMENTO TERRITORIAL E SISTEMAS AGROINDUSTRIAIS BOAS PRÁTICAS DA PUBLICAÇÃO - ANPAD AVALIADORES 2012 AVALIADORES 2013 AVALIADORES 2014 AVALIADORES 2015 CAPA > V. 7, N. 4 (2015 >\tCHEUNG INOVAÇÕES EM ALIMENTAÇÃO: AS PERCEPÇÕES DOS CONSUMIDORES SOBRE PRODUTOS ENRIQUECIDOS E TRANSGÊNICOS RESUMO Thelma Lucchese Cheung, Claudia Macedo, Thiago Neves, Wellington da Silva Rodrigues Resumo Pretendeu-se neste artigo apresentar as percepções de um grupo de consumidores brasileiros em relação às inovações no setor de alimentos. Questionados sobre os alimentos transformados, geneticamente modificados e transgênicos que estão no mercado as opiniões dos indivíduos, cheias de valores e atitudes, permitiram a este estudo observar suas representações dessas inovações. O estudo que deu origem a este artigo é exploratório e qualitativo. Questões abertas de um questionário foram utilizadas para compreender as percepções da amostra sobre as inovações estudadas. As declarações de indivíduos adultos, de 20 a 40 anos, de ambos os gêneros e com alto nível de escolaridade e habitantes de diferentes estados brasileiros revelaram reações positivas quanto aos produtos modificados e transgênicos, associando-os com avanços da ciência e benefícios das descobertas científicas como alternativas de consumo conveniente e mais saudável.

  14. Extreme QCD 2012 (xQCD)

    Science.gov (United States)

    2013-04-01

    Acknowledgements This conference would not have been possible without the generous support from Brookhaven National Laboratory and the George Washington University INS and IMPACT institutes, Columbian College of Arts and Sciences, the Office of Vice-President for Research, and the Department of Physics. We thank them wholeheartedly. We are also very grateful for the support of our colleagues on the local organizing committee, Walter Freeman and Frank Lee, and on the International Advisory Committee: Simon Hands, Tetsuo Hatsuda, Frithjof Karsch, Maria Paola Lombardo, Tereza Mendes, Atsushi Nakamura, Owe Philipsen, Claudia Ratti, Paul Romatschke, Misha Stephanov, and Nu Xu. List of participants Alexandru, Andrei George Washington University Bazavov, Alexei Brookhaven National Laboratory Bloch, Jacques University of Regensburg Braun-Munzinger, Peter EMMI, GSI Breto Rangel, Guillermo CMS/UC Davis D'Elia, Massimo University of Pisa, INFN Dexheimer, Veronica UFSC - Federal University of Santa Catarina Ding, Heng-Tong Brookhaven National Laboratory Dion, Alan Stony Brook University Dumitru, Adrian RBRC and Baruch College, CUNY Freeman, Walter George Washington University Gavai, Rajiv Tata Institute (TIFR), Mumbai Hanada, Masanori KEK Theory Center Hands, Simon Swansea University Hegde, Prasad Brookhaven National Laboratory Heinke, Craig University of Alberta Horvath, Ivan University of Kentucky Karsch, Frithjof Brookhaven National Laboratory Krieg, Stefan Wuppertal University Lattimer, James Stony Brook University Lee, Frank George Washington University Li, Anyi Institute for Nuclear Theory Liu, Keh-Fei University of Kentucky Lombardo, Maria Paola INFN - LNF Lottini, Stefano Goethe University, Frankfurt am Main Maezawa, Yu Brookhaven National Laboratory Miura, Kohtaroh Laboratori Nazionali di Frascati - INFN Monnai, Akihiko The University of Tokyo Mukherjee, Swagato Brookhaven National Laboratory Myers, Joyce University of Groningen Nakamura, Atsushi RIISE, Hiroshima

  15. Extubation process in bed-ridden elderly intensive care patients receiving inspiratory muscle training: a randomized clinical trial

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    Cader SA

    2012-10-01

    Full Text Available Samária Ali Cader,1 Rodrigo Gomes de Souza Vale,1 Victor Emmanuel Zamora,2 Claudia Henrique Costa,2 Estélio Henrique Martin Dantas11Laboratory of Human Kinetics Bioscience, Federal University of Rio de Janeiro State, 2Pedro Ernesto University Hospital, School of Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilBackground: The purpose of this study was to evaluate the extubation process in bed-ridden elderly intensive care patients receiving inspiratory muscle training (IMT and identify predictors of successful weaning.Methods: Twenty-eight elderly intubated patients in an intensive care unit were randomly assigned to an experimental group (n = 14 that received conventional physiotherapy plus IMT with a Threshold IMT® device or to a control group (n = 14 that received only conventional physiotherapy. The experimental protocol for muscle training consisted of an initial load of 30% maximum inspiratory pressure, which was increased by 10% daily. The training was administered for 5 minutes, twice daily, 7 days a week, with supplemental oxygen from the beginning of weaning until extubation. Successful extubation was defined by the ventilation time measurement with noninvasive positive pressure. A vacuum manometer was used for measurement of maximum inspiratory pressure, and the patients' Tobin index values were measured using a ventilometer.Results: The maximum inspiratory pressure increased significantly (by 7 cm H2O, 95% confidence interval [CI] 4–10, and the Tobin index decreased significantly (by 16 breaths/min/L, 95% CI −26 to 6 in the experimental group compared with the control group. The Chi-squared distribution did not indicate a significant difference in weaning success between the groups (Χ2 = 1.47; P = 0.20. However, a comparison of noninvasive positive pressure time dependence indicated a significantly lower value for the experimental group (P = 0.0001; 95% CI 13.08–18.06. The receiver

  16. The perspectives of older women with chronic neck pain on perceived effects of qigong and exercise therapy on aging: a qualitative interview study

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    Holmberg C

    2014-03-01

    Full Text Available Christine Holmberg,1,2 Julia Rappenecker,1 Julia J Karner,1 Claudia M Witt1,3 1Institute for Social Medicine, Epidemiology, and Health Economics, 2Berlin School of Public Health, Charité – Universitätsmedizin Berlin, Berlin, Germany; 3Center for Complementary and Integrative Medicine, University Hospital Zurich, Zurich, Switzerland Abstract: Chronic pain is prevalent in elderly populations. The goals of this study were 1 to understand the results of a randomized clinical trial – Qigong and Exercise Therapy for Elderly Patients with Chronic Neck Pain (QIBANE – that showed no difference between qigong, exercise therapy, and no-treatment on quality of life, and 2 to understand how elderly individuals with chronic pain experience interventions of qigong and exercise therapy. A qualitative interview study was conducted with 20 QIBANE participants. Interviews asked about motivation for and expectations of trial participation, experiences with the exercise classes (qigong or exercise therapy, and changes in pain experience. Interviews were transcribed, entered into the software program ATLAS.ti, and coded thematically by two coders. Content analysis was performed. All interviewees reflected positively on their QIBANE experience and described their participation in QIBANE as helpful. However, what was discussed in both groups when they talked about “positive experiences” in the study differed between the two groups. For example, themes that emerged in the exercise-therapy group related to difficulties associated with aging and staying physically active. In the interviews with qigong group members, emergent themes related to qigong as a method that improved bodily experiences and influenced daily activities. The effects that exercise therapy and qigong have on an elderly population cannot be captured by health-related quality-of-life measurements, such as the Short Form (36 Health Survey. Broader concepts of quality of life that include the

  17. Implementation of the Blended Care Self-Management Program for Caregivers of People With Early-Stage Dementia (Partner in Balance): Process Evaluation of a Randomized Controlled Trial.

    Science.gov (United States)

    Boots, Lizzy Mm; de Vugt, Marjolein E; Smeets, Claudia Mj; Kempen, Gertrudis Ijm; Verhey, Frans Rj

    2017-12-19

    , time, and deviating target population. Participants and coaches were satisfied with the intervention, but adapting the content to specific subgroups, for example, younger caregivers, was recommended. Implementation of the program requires more awareness of the benefits of blended care self-management programs and training in tailored self-management skills. Dutch Trial Register (NTR): NTR4748; http://www.trialregister.nl (Archived by WebCite at http://www.webcitation.org/6vSb2t9Mg). ©Lizzy MM Boots, Marjolein E de Vugt, Claudia MJ Smeets, Gertrudis IJM Kempen, Frans RJ Verhey. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.12.2017.

  18. Short-Term Efficacy of an Innovative Mobile Phone Technology-Based Intervention for Weight Management for Overweight and Obese Adolescents: Pilot Study.

    Science.gov (United States)

    Chen, Jyu-Lin; Guedes, Claudia M; Cooper, Bruce A; Lung, Audrey E

    2017-08-02

    .75, P=.006), and dietary self-efficacy (z=5.05, P=.001). Medium to large effect sizes were found in these outcome variables. The use of mobile technologies may offer a practical, reliable adjunct to weight management for overweight and obese adolescents in busy primary care clinics serving adolescents. Clinicaltrials.gov NCT 01693250; https://clinicaltrials.gov/ct2/show/NCT01693250? term=Adolescent+ obesity+AND+mhealth&rank=5 (Archived by WebCite at ). ©Jyu-Lin Chen, Claudia M Guedes, Bruce A Cooper, Audrey E Lung. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 02.08.2017.

  19. Proceedings of the 19th ASPA Congress, Cremona, June 7-10, 2011

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    Guest Editor: Giacomo Pirlo

    2011-06-01

    Full Text Available The 19th Congress of the Animal Science and Production Association (ASPA, is held in the capital of one of the main European regions for animal production: Cremona. Despite its Gallic origin (Carra = rock, the name Cremona means big cream in modern Italian, in a clear allusion to milk. In this Congress, 153 oral presentations and 165 posters are presented, for a total of 318 scientific contributions. The Congress sessions with their relative number of papers are listed as follows: Animal breeding and genetics 87, Nutrition and feeding 57, Dairy production 40, Meat production 46, Animal welfare, Health and behaviour 37, Poultry and rabbit production 28 and Aquaculture 23. I would like to point out that 4 main lectures will be presented in the Animal breeding and genetics and Nutrition and feeding sessions (two in each, and that the Consiglio per la Ricerca in Agricoltura (Agricultural Research Council, the Agricultural Ministery research agency, which took charge of organizing the Congress, will award a prize for the best work here presented by young researchers. I would thank, first of all, Prof. Paolo Cescon, President of the Congress, for the contribution of all the CRA in organizing this event. I would also thank all the members of the Scientific Committee, dr. Riccardo Aleandri (President, dr. Fabio Abeni, dr. Fabiola Canavesi, dr. Giacinto Della Casa and dr. Marisanna Speroni, and of the Organizing Committee, dr. Giovanni Lo Piparo (President, dr. Stefania Barzaghi, dr. Maurizio Capelletti, dr. Giorgio Giraffa and dr. Luciano Migliorati. A special thanks to the secretary components, Maria Dissegna and Patrizia Re, assisted by Claudia Federici, Francesca Petrera, Miriam Odoardi, Maddalena Carli, Caterina Sanna, Stefania Marruso, Leonardo Boselli, Milena Rosi and Aldo Dal Prà. A special acknowlegment to Giacomo Pirlo, the real driving force organizing the Congress, a tireless and enthusiastic embroiderer of opportunities in scientific and

  20. Systemic effects of chronic obstructive pulmonary disease in young-old adults’ life-space mobility

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    Garcia IFF

    2017-09-01

    Full Text Available Isabel Fialho Fontenele Garcia,1 Carina Tiemi Tiuganji,1 Maria do Socorro Morais Pereira Simões,2 Ilka Lopes Santoro,3 Adriana Claudia Lunardi1,2 1Master’s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, 2Department of Physical Therapy, School of Medicine, University of Sao Paulo, 3Respiratory Division, Pulmonary Rehabilitation Center, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil Purpose: The objective was to assess whether dyspnea, peripheral muscle strength and the level of physical activity are correlated with life-space mobility of older adults with COPD.Patients and methods: Sixty patients over 60 years of age (40 in the COPD group and 20 in the control group were included. All patients were evaluated for lung function (spirometry, life-space mobility (University of Alabama at Birmingham Study of Aging Life-Space Assessment, dyspnea severity (Modified Dyspnea Index, peripheral muscle strength (handgrip dynamometer, level of physical activity and number of daily steps (accelerometry. Groups were compared using unpaired t-test. Pearson’s correlation was used to test the association between variables.Results: Life-space mobility (60.41±16.93 vs 71.07±16.28 points, dyspnea (8 [7–9] vs 11 [10–11] points, peripheral muscle strength (75.16±14.89 vs 75.50±15.13 mmHg, number of daily steps (4,865.4±2,193.3 vs 6,146.8±2,376.4 steps, and time spent in moderate to vigorous activity (197.27±146.47 vs 280.05±168.95 minutes were lower among COPD group compared to control group (p<0.05. The difference was associated with the lower mobility of COPD group in the neighborhood.Conclusion: Life-space mobility is decreased in young-old adults with COPD, especially at the neighborhood level. This impairment is associated to higher dyspnea, peripheral muscle weakness and the reduced level of physical activity. Keywords: COPD, elderly, mobility limitation, dyspnea, muscular

  1. Near-fatal asthma responsive to mepolizumab after failure of omalizumab and bronchial thermoplasty

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    Menzella F

    2017-11-01

    Full Text Available Francesco Menzella,1 Carla Galeone,1 Mirco Lusuardi,2 Anna Simonazzi,1 Claudia Castagnetti,1 Patrizia Ruggiero,1 Nicola Facciolongo1 1Department of Medical Specialties, Pneumology Unit, Arcispedale Santa Maria Nuova – IRCCS, Azienda USL di Reggio Emilia, Reggio Emilia, 2Unit of Respiratory Rehabilitation, Azienda USL di Reggio Emilia, S. Sebastiano Hospital, Correggio, Italy Abstract: Severe asthma affects between 5% and 10% of patients with asthma worldwide and requires best standard therapies at maximal doses, but there is a subgroup of patients refractory to all treatments. We share a case report of a 53-year-old woman with a history of severe allergic asthma that progressively worsened over the years despite the best therapy. She had been hospitalized 35 times, including nine admissions to the respiratory intensive care unit due to severe exacerbations. To rule out other possible diagnoses, several investigations were performed, such as computed tomography scan of the chest and neck, fiberoptic laryngoscopy, antineutrophil cytoplasmic antibodies, and complete blood cell count. The patient was first treated with omalizumab, which was completely ineffective, and then with bronchial thermoplasty (BT, again without clinical benefit. The situation remained critical for about 3 months during the last hospitalization, but in February 2017, the Italian Medicines Agency approved the treatment of severe refractory eosinophilic asthma with mepolizumab (Nucala®. Given a blood eosinophil count of 300 cells/µL, our patient was started on 100 mg mepolizumab treatment. After the second administration, symptoms improved progressively, with a reduction in the number and severity of exacerbations, so the patient could finally be discharged from hospital. At follow-up, it was possible to reduce and then suspend oral corticosteroids by continuing only with inhaled corticosteroids/long-acting beta-agonists and montelukast. No further asthmatic exacerbations

  2. The StratusLab cloud distribution: Use-cases and support for scientific applications

    Science.gov (United States)

    Floros, E.

    2012-04-01

    The StratusLab project is integrating an open cloud software distribution that enables organizations to setup and provide their own private or public IaaS (Infrastructure as a Service) computing clouds. StratusLab distribution capitalizes on popular infrastructure virtualization solutions like KVM, the OpenNebula virtual machine manager, Claudia service manager and SlipStream deployment platform, which are further enhanced and expanded with additional components developed within the project. The StratusLab distribution covers the core aspects of a cloud IaaS architecture, namely Computing (life-cycle management of virtual machines), Storage, Appliance management and Networking. The resulting software stack provides a packaged turn-key solution for deploying cloud computing services. The cloud computing infrastructures deployed using StratusLab can support a wide range of scientific and business use cases. Grid computing has been the primary use case pursued by the project and for this reason the initial priority has been the support for the deployment and operation of fully virtualized production-level grid sites; a goal that has already been achieved by operating such a site as part of EGI's (European Grid Initiative) pan-european grid infrastructure. In this area the project is currently working to provide non-trivial capabilities like elastic and autonomic management of grid site resources. Although grid computing has been the motivating paradigm, StratusLab's cloud distribution can support a wider range of use cases. Towards this direction, we have developed and currently provide support for setting up general purpose computing solutions like Hadoop, MPI and Torque clusters. For what concerns scientific applications the project is collaborating closely with the Bioinformatics community in order to prepare VM appliances and deploy optimized services for bioinformatics applications. In a similar manner additional scientific disciplines like Earth Science can take

  3. Apresentação do Dossiê

    Directory of Open Access Journals (Sweden)

    Maria Cecília Coelho

    2013-12-01

    Full Text Available Este dossiê reúne textos apresentados, em sua maioria, durante o XIX Congresso da Sociedade Brasileira de Estudos Clássicos e no decorrer do I Simpósio Luso-Brasileiro de Estudos Clássicos – O Futuro do Passado, que aconteceu em julho de 2013, em Brasília/Distrito Federal. O dossiê contém quatro artigos e um ensaio, lido em uma palestra, ao qual segue anexo um comentário de seu moderador. Três dos artigos são frutos do painel proposto e organizado, durante o XIX Congresso, pelo Núcleo de Estudos Antigos e Medievais da Faculdade de Letras da Universidade Federal de Minas Gerais (NEAM/FALE/UFMG, do qual sou membro. No painel, intitulado “Recepção da cultura greco-romana no cinema, no teatro e na literatura”, foram apresentados textos de autoria de professores da área de língua e literatura gregas, que trabalham na Argentina, nos Estados Unidos e na Polônia: Claudia Fernández (Universidade de La Plata, Eric Dugdale (Gustavus Adolphus College e Ewa Skwara (Adam-Mickiewicz University, respectivamente. Quanto ao ensaio, trata-se do texto do cineasta português João Canijo, em cuja obra se destaca a adaptação de tragédias gregas para o cinema. O ensaio é seguido do comentário de Christian Werner (Universidade de São Paulo, tradutor e professor de língua e literatura gregas. O quarto artigo, de minha autoria, apesar de ter sido resultado, em parte, de uma palestra que apresentei em outro momento (no VI Colóquio Filosofia e Ficção – Phantasia e Phantasmas, foi, pela proximidade com o tema do painel que coordenei nesse XIX Congresso, inserido neste dossiê.

  4. Nicoboxil/nonivamide cream effectively and safely reduces acute nonspecific low back pain – a randomized, placebo-controlled trial

    Directory of Open Access Journals (Sweden)

    Blahova Z

    2016-12-01

    Full Text Available Zuzana Blahova,1 Janina Claudia Holm,1 Thomas Weiser,2 Erika Richter,2 Matthias Trampisch,2 Elena Akarachkova3 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria; 2Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; 3I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation Background/objective: Low back pain affects many patients and has a high socioeconomic impact. Topical capsaicinoids have been used for decades to treat musculoskeletal pain. This study investigated the effects of the fixed dose combination (FDC of nonivamide (a capsaicinoid and nicoboxil (a nicotinic acid ester cream in the treatment of acute nonspecific low back pain.Materials and methods: This phase III randomized, double-blind, placebo-controlled, multinational, multi-center trial investigated efficacy, safety, and tolerability of topical nicoboxil 1.08%/nonivamide 0.17% (Finalgon® cream in treatment of acute nonspecific low back pain with the endpoints: pain intensity (PI difference between pre-dose baseline and 8 hours after first application and the end of treatment, mobility score, and efficacy score.Results: Patients (n=138, 21–65 years of age, were treated for up to 4 days with FDC or placebo cream. Mean baseline PI was 6.8 on a 0–10 point numerical rating scale. After 8 hours, pain was more reduced with the FDC than with placebo (adjusted means: 2.824 vs. 0.975 points; p<0.0001. On the last treatment day, mean pain reduction by the FDC was stronger than with placebo (adjusted means: 5.132 vs. 2.174 points; p<0.0001. Mobility on Day 1 was in favor of the FDC when compared to placebo (odds ratio [95% confidence interval {CI}]: 7.200 [3.609, 14.363], p<0.0001. At the end of treatment, patients treated with the FDC rated efficacy significantly higher than placebo (odds ratio [95% CI]: 11.370 [5.342, 24.199], p<0.0001. Both treatments were tolerated well. No serious adverse events were reported.Conclusion: Nicoboxil

  5. For-profit colleges.

    Science.gov (United States)

    Deming, David; Goldin, Claudia; Katz, Lawrence

    2013-01-01

    For-profit, or proprietary, colleges are the fastest-growing postsecondary schools in the nation, enrolling a disproportionately high share of disadvantaged and minority students and those ill-prepared for college. Because these schools, many of them big national chains, derive most of their revenue from taxpayer-funded student financial aid, they are of interest to policy makers not only for the role they play in the higher education spectrum but also for the value they provide their students. In this article, David Deming, Claudia Goldin, and Lawrence Katz look at the students who attend for-profits, the reasons they choose these schools, and student outcomes on a number of broad measures and draw several conclusions. First, the authors write, the evidence shows that public community colleges may provide an equal or better education at lower cost than for-profits. But budget pressures mean that community colleges and other nonselective public institutions may not be able to meet the demand for higher education. Some students unable to get into desired courses and programs at public institutions may face only two alternatives: attendance at a for-profit or no postsecondary education at all. Second, for-profits appear to be at their best with well-defined programs of short duration that prepare students for a specific occupation. But for-profit completion rates, default rates, and labor market outcomes for students seeking associate's or higher degrees compare unfavorably with those of public postsecondary institutions. In principle, taxpayer investment in student aid should be accompanied by scrutiny concerning whether students complete their course of study and subsequently earn enough to justify the investment and pay back their student loans. Designing appropriate regulations to help students navigate the market for higher education has proven to be a challenge because of the great variation in student goals and types of programs. Ensuring that potential

  6. Preliminary pediatric clinical evaluation of the oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes and recurrent acute otitis media

    Directory of Open Access Journals (Sweden)

    Di Pierro F

    2012-11-01

    Full Text Available Francesco Di Pierro,1 Guido Donato,2 Federico Fomia,3 Teresa Adami,4 Domenico Careddu,5 Claudia Cassandro,6 Roberto Albera61Scientific Department, Velleja Research, Milano, 2ASL 1, Cuneo, 3ASL 3, Brescia, 4Infective Diseases, Verona, 5ASL 13, Novara, 6Surgical Science Department, Università degli Studi, Torino, ItalyBackground: The oral probiotic Streptococcus salivarius K12 has been shown clearly to antagonize the growth of Streptococcus pyogenes, the most important bacterial cause of pharyngeal infections in humans, by releasing two bacteriocins named salivaricin A2 and salivaricin B. Unpublished observations indicate that it can also antagonize the growth of other bacteria involved in acute otitis media. Because of its ability to colonize the oral cavity and its safety profile, we have tested its efficacy in reducing the incidence of streptococcal pharyngitis and/or tonsillitis and episodes of acute otitis media.Methods: We enrolled 82 children, including 65 with and 17 without a recent diagnosis of recurrent oral streptococcal pathology. Of those with recurrent pathology, 45 were treated daily for 90 days with an oral slow-release tablet containing five billion colony-forming units of S. salivarius K12 (Bactoblis®, and the remaining 20 served as an untreated control group. The 17 children without a recent diagnosis of recurrent oral pathology were used as an additional control group. After 90 days of treatment, a 6-month follow-up period without treatment was included to evaluate a possible persistent protective role for the previously administered product.Results: The 41 children who completed the 90-day course of Bactoblis showed a reduction in their episodes of streptococcal pharyngeal infection (about 90% and/or acute otitis media (about 40%, calculated by comparing infection rates in the previous year. The 90-day treatment also reduced the reported incidence of pharyngeal and ear infections by about 65% in the 6-month follow-up period

  7. Ver, Compreender e Aprender: estudo comparado com guias de uso de apps editoriais para dispositivos móveis

    Directory of Open Access Journals (Sweden)

    Ana Claudia Dalagnoli

    2016-12-01

    Full Text Available Este estudo foi construído a partir da percepção de que a evolução das tecnologias e, sobretudo, o aprimoramento da comunicação em dispositivos móveis, impacta diretamente no processo de desenvolvimento de aplicativos (apps e softwares e na relação do ser humano com as novas interfaces. A pesquisa apresenta uma análise comparativa entre os aplicativos para iPad das revistas de decoração e design de interiores Casa Claudia (Editora Abril e Casa e Jardim (Editora Globo, a partir de testes de usabilidade dos mesmos em tablets Apple. O objetivo foi verificar se os guias de uso disponíveis em aplicativos (apps de revistas para dispositivos móveis, construídos por textos e imagens, estão cumprindo a função de comunicar, efetivamente, o modo de uso desses apps. As informações foram coletadas junto a mulheres com idade entre 25 e 54 anos que testaram e comentaram o funcionamento das versões atuais dos apps. Foram selecionadas 24 mulheres para fazerem atividades individuais monitoradas em ambos os apps, com dados coletados por meio de observações e think aloud. Os dados obtidos foram analisados, e com base nos resultados foi proposto um ajuste nos requisitos para o desenvolvimento de interfaces de guias para aplicativos com vistas à maior satisfação das usuárias. Foram percebidas falhas severas na apreensão e aplicação das orientações disponíveis nos guias de uso. Os pesquisadores verificaram que os requisitos básicos para aumentar a satisfação e melhorar a usabilidade estão relacionados à facilidade de compreensão e à simplicidade no uso, o que pode ser obtido por meio de melhorias relacionadas à aplicação da tecnologia, ao conhecimento dos processos cognitivos dos usuários e à aplicação de conceitos semióticos de comunicação. O estudo pode servir de base para o desenvolvimento e análise de guias de uso de outros apps com características similares, em diversos sistemas operacionais.

  8. Estimating the real world daily usage and cost for exenatide twice daily and liraglutide in Germany, the Netherlands, and the UK based on volumes dispensed by pharmacies

    Directory of Open Access Journals (Sweden)

    McDonell AL

    2015-01-01

    Full Text Available Amanda L McDonell,1 Urpo Kiiskinen,2 Danielle C Zammit,3 Robert W Kotchie,1 Per-Olof Thuresson,3 Claudia Nicolay,4 Thomas Haslam,1 Michiel Bruinsma,5 Anne-Jeanine Janszen-Van Oosterhout,6 Thorsten Otto41IMS Health, London, UK; 2Eli Lilly and Company, Helsinki, Finland; 3IMS Health, Basel, Switzerland; 4Eli Lilly and Company, Bad Homburg, Germany; 5IMS Health, Rotterdam, the Netherlands; 6Eli Lilly Nederland, Houten, the NetherlandsBackground: Glucagon-like peptide-1 (GLP-1 receptor agonists are indicated for improvement of glycemic control in adults with type 2 diabetes. Cost is one aspect of treatment to be considered, in addition to clinical benefits, when selecting optimal therapy for a patient. The objective of this study was to estimate the average dose usage and real world daily cost of the GLP-1 receptor agonists, exenatide twice daily and liraglutide once daily, in Germany, the Netherlands, and the UK.Methods: Administrative databases were used to source the data from longitudinal records of dispensed prescriptions. Data were extracted from the IMS Longitudinal Prescription database which captures details of prescriptions dispensed in pharmacies. Information on the dispensed quantity of each product was used to estimate average daily usage per patient. Daily dose usage was multiplied by the public price per unit to estimate daily cost.Results: The dispensed volume in Germany corresponded to a mean dispensed daily dose of 16.81 µg for exenatide twice daily and 1.37 mg for liraglutide (mean daily cost €4.02 and €4.54, respectively. In the Netherlands, average dispensed daily doses of 17.07 µg and 1.49 mg were observed for exenatide twice daily and liraglutide (mean daily cost €3.05 and €3.97, respectively. In the UK, the mean dispensed volume corresponded to a daily usage of 20.49 µg for exenatide twice daily and 1.50 mg for liraglutide (mean daily cost £2.53 and £3.28, respectively.Conclusion: Estimates of average daily

  9. Baseline blood immunological profiling differentiates between Her2– breast cancer molecular subtypes: implications for immunomediated mechanisms of treatment response

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    Tudoran O

    2015-11-01

    Full Text Available Oana Tudoran,1,2,* Oana Virtic,2,* Loredana Balacescu,1,2 Carmen Lisencu,3 Bogdan Fetica,4 Claudia Gherman,1 Ovidiu Balacescu,1 Ioana Berindan-Neagoe1,2,5 1Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof Dr Ion Chiricuţă”, 2Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 3Department of Radiotherapy I, 4Department of Pathology, The Oncology Institute “Prof Dr Ion Chiricuţă”, 5Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania *These authors contributed equally to this work Purpose: Breast cancer patients’ response to treatment is highly dependent on the primary tumor molecular features, with triple-negative breast tumors having the worst prognosis of all subtypes. According to the molecular features, tumors stimulate the microenvironment to induce distinct immune responses, baseline immune activation being associated with higher likelihood of pathologic response. In this study, we investigated the deconvolution of the immunological status of triple-negative tumors in comparison with luminal tumors and the association with patients’ clinicopathological characteristics.Patients and methods: Gene expression of 84 inflammatory molecules and their receptors were analyzed in 40 peripheral blood samples from patients with Her2- primary breast cancer tumors. We studied the association of triple-negative phenotype with age, clinical stage, tumor size, lymph nodes, and menopausal status.Results: We observed that more patients with estrogen (ER/progesterone (PR-negative tumors had grade III, while more patients with ER/PR-positive tumors had grade II tumors. Gene expression analysis revealed a panel of 14 genes to have differential expression between the two groups: several interleukins: IL13, IL16, IL17C and IL17F, IL1A, IL3; interleukin receptors: IL10RB, IL5RA; chemokines: CXCL13 and CCL

  10. Seal boxes from the Viminacium site

    Directory of Open Access Journals (Sweden)

    Milovanović Bebina

    2013-01-01

    Full Text Available Bronze seal boxes that had the function of holding the wax seal on the Viminacium site - Upper Moesia (Stari Kostolac, Serbia, mainly from the area of the necropolis (ten were found in the graves and ten at the cemetery between the graves. Six are from buildings that had a storage function, five are from public facilities - an amphitheatre, and only one find is from the military fort of the legion VII Claudia, which was stationed in Viminacium in the second half of the 1st century. Thirty-two seal boxes have been processed: nine whole, six with fragmented upper and lower parts, seven bases and ten covers. Seal boxes consist of two parts: the cover and the base. The cover is decorated with figural images, concentric rings and especially with applied ornaments. Some of the motifs are filled with enamel. The base always has three to five circular perforations at the bottom, the side walls are a height of 4 to 5 mm with two opposed notches or slots which are thought to have facilitated the tying of the seal box to a package or a document. The lock mechanism is operated using the hinges principle. Some specimens have a circular extension on the cover with a thorn on the bottom. This fits the hollow in the base, through which passes a thorn for the additional fixing of the cover. Based on shape and decoration, seal boxes were classified into five types: I - elliptical or oval shaped with a figural representation on the cover derived in relief; II/1 - leaf or heart-shaped with a special, riveted ornament; II/2 - leaf or heart-shaped with enamel on the cover; III/1 - circular showing a form in relief; III/2 - circular with cast concentric rings, with no enamel; III/3 - circular with concentric rings with enamel on the cover; IV - diamond shaped with enamel on the cover and V - square with enamel on the cover. The seal boxes dominate chronologically from the first half of the 2nd and throughout the 3rd century.

  11. Anthroposophic therapy for attention deficit hyperactivity: A two-year prospective study in outpatients

    Directory of Open Access Journals (Sweden)

    Harald J Hamre

    2010-08-01

    Full Text Available Harald J Hamre1, Claudia M Witt2, Gunver S Kienle1, Christoph Meinecke3, Anja Glockmann1, Renatus Ziegler4, Stefan N Willich2, Helmut Kiene11Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany; 2Institute of Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, Germany; 3Pediatric Consultant, Community Hospital Havelhöhe, Berlin, Germany; 4Society for Cancer Research, Arlesheim, SwitzerlandBackground: Anthroposophic treatment for attention deficit hyperactivity disorder (ADHD includes special artistic and physical therapies and special medications.Methods: We studied 61 consecutive children starting anthroposophic treatment for ADHD symptoms under routine outpatient conditions. Primary outcome was FBB-HKS (a parents’ questionnaire for ADHD core symptoms, 0–3, and secondary outcomes were disease and symptom scores (physicians’ and parents’ assessment, 0–10 and quality of life (KINDL® total score, 0–100.Results: A total of 67% of patients fulfilled the DSM-IV criteria for ADHD, 15% had an exclusion diagnosis such as pervasive developmental disorders, while 18% did not fulfill ADHD criteria for another reason. Anthroposophic treatment modalities used were eurythmy therapy (in 56% of patients, art therapy (20%, rhythmical massage therapy (8%, and medications (51%. From baseline to six-month follow-up, all outcomes improved significantly; average improvements were FBB-HKS total score 0.30 points (95% confidence interval [CI]: 0.18–0.43; P < 0.001, FBB-HKS inattention 0.36 (95% CI: 0.21–0.50; P < 0.001, FBB-HKS hyperactivity 0.29 (95% CI: 0.14–0.44; P < 0.001, FBB-HKS impulsivity 0.22 (95% CI: 0.03–0.40; P < 0.001, disease score 2.33 (95% CI: 1.84–2.82; P < 0.001, symptom score 1.66 (95% CI: 1.17–2.16; P < 0.001, and KINDL 5.37 (95% CI: 2.27–8.47; P = 0.001. Improvements were similar in patients not using stimulants (90% of patients at months 0–6 and

  12. “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD

    Directory of Open Access Journals (Sweden)

    Vogelmeier C

    2017-02-01

    Full Text Available Claus Vogelmeier,1 Heinrich Worth,2 Roland Buhl,3 Carl-Peter Criée,4 Nadine S Lossi,5 Claudia Mailänder,5 Peter Kardos6 1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL, Marburg, 2Facharzt Forum Fürth, Fürth, 3Pulmonary Department, Mainz University Hospital, Mainz, 4Department of Sleep and Respiratory Medicine, Evangelical Hospital Göttingen-Weende, Bovenden, 5Clinical Research, Respiratory, Novartis Pharma GmbH, Nürnberg, 6Group Practice and Centre for Allergy, Respiratory and Sleep Medicine, Red Cross Maingau Hospital, Frankfurt am Main, Germany Abstract: Many patients with chronic obstructive pulmonary disease (COPD receive inhaled corticosteroids (ICSs without a clear indication, and thus, the impact of ICS withdrawal on disease control is of great interest. DACCORD is a prospective, noninterventional 2-year study in the primary and secondary care throughout Germany. A subgroup of patients were taking ICS prior to entry – 1,022 patients continued to receive ICS for 2 years; physicians withdrew ICS on entry in 236 patients. Data from these two subgroups were analyzed to evaluate the impact of ICS withdrawal. Patients aged ≥40 years with COPD, initiating or changing COPD maintenance medication were recruited, excluding patients with asthma. Demographic and disease characteristics, prescribed COPD medication, COPD Assessment Test, exacerbations, and lung function were recorded. There were few differences in baseline characteristics; ICS withdrawn patients had shorter disease duration and better lung function, with 74.2% of ICS withdrawn patients not exacerbating, compared with 70.7% ICS-continued patients. During Year 1, exacerbation rates were 0.414 in the withdrawn group and 0.433 in the continued group. COPD Assessment Test total score improved from baseline in both groups. These data suggest

  13. High frequency equipment promotes antibacterial effects dependent on intensity and exposure time

    Directory of Open Access Journals (Sweden)

    Wietzikoski Lovato EC

    2018-03-01

    Full Text Available Evellyn Claudia Wietzikoski Lovato,1 Patrícia Amaral Gurgel Velasquez,1 Cristiana dos Santos Oliveira,1 Camila Baruffi,1 Thais Anghinoni,1 Raquel Costa Machado,1 Francislaine Aparecida dos Reis Lívero,2 Samantha Wietzikoski Sato,1 Lisiane de Almeida Martins1 1Laboratory of Microbiology of Natural Products, Paranaense University, Umuarama, Brazil; 2Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil Background: The indiscriminate use of antibiotics has caused bacteria to develop mechanisms of resistance to antibacterial agents, limiting treatment options. Therefore, there is a great need for alternative methods to control infections, especially those related to skin. One of the alternative methods is the high frequency equipment (HFE, which is used on skin conditions as an analgesic, an anti-inflammatory, and mainly to accelerate cicatricial processes and have a bactericidal effect through the formation of ozone. This research investigated the antibacterial effect of HFE on standard cultures of bacteria.Materials and methods: Dilutions (104 colony forming unit mL−1 were performed for Enterobacter aerogenes and Staphylococcus aureus with 24-hour growth bacteria. Then, 1 μL of each dilution was pipetted into suitable medium and the HFE flashing technique was used at intensities of 6, 8 and 10 mA for 30, 60, 90, 120 and 180 seconds. The control group received no treatment. Plates were incubated at 37°C for 24 hours and then read.Results: The spark at intensity of 6 mA had no bactericidal effect on the E. aerogenes; however, a significant bacterial growth reduction occurred at intensity of 8 mA after 120 and 180 seconds, and at 10 mA, reduction in bacterial growth could already be verified at 30 seconds and total bacterial growth inhibition occurred in 180 seconds. For S. aureus, there was a strong bacterial growth inhibition at all intensities used; however, at 6 mA, absence of bacterium growth after

  14. El subsuelo de la Torre del Pretorio: substructiones de tradición helenística bajo la sede del Concilium Prouinciae Hispaniae Citerioris (Tarraco

    Directory of Open Access Journals (Sweden)

    Serena Vinci, M.

    2014-12-01

    Full Text Available This paper presents the study of a complex architectonical area within the so-called provincial forum of Tarraco. The analysis of the architectonical stratigraphy and of the construction processes has been a fundamental tool to understand an area characterized by a complicated urban evolution, showing the development of the building project of such a vast construction as it is the provincial forum. Unfortunately, the absence of data provided by archaeological excavations limits the definition of a precise absolute chronology. The process of transforming the top of Tarraco’s hill into a monumental area started, according to historical and numismatic sources, during the Julio-Claudian era was completed in the Flavian one by ending this monumental complex distributed in three platforms. The area here analysed, placed close to the circus, belongs to a system of substructiones which commonly features those forum and sacred complexes organized in platforms at different levels.El artículo presenta el estudio de un área arquitectónicamente compleja, integrada dentro del denominado Foro Provincial de Tarraco. El análisis de la estratigrafía arquitectónica y de los procesos de construcción, ha representado un instrumento fundamental para la interpretación de un área caracterizada por una compleja evolución urbanística, poniendo en evidencia el desarrollo del proyecto constructivo de una obra de gran envergadura como la del Foro Provincial. Desafortunadamente, la ausencia de datos procedentes de las excavaciones arqueológicas, ha limitado la definición de una cronología absoluta exacta. El proceso de monumentalización de la cima de la colina tarraconense iniciado, según las fuentes históricas y numismáticas, en época julio-claudia, culminó en época Flavia con la finalización del complejo monumental distribuido en tres terrazas. El sector que se examina, situado junto al circo, se encuadra dentro de un sistema de substructiones que a

  15. Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients

    Directory of Open Access Journals (Sweden)

    Salgado PC

    2017-03-01

    Full Text Available Patricia C Salgado,1 Fabiana DV Genvigir,1 Claudia R Felipe,2 Helio Tedesco-Silva Jr,2 Jose O Medina-Pestana,2 Sonia Q Doi,3 Mario H Hirata,1 Rosario DC Hirata1 1Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, 2Division of Nephrology, Hospital do Rim, Federal University of Sao Paulo, Sao Paulo, Brazil; 3School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Background: The effects of genetic variants related to the pharmacodynamic mechanisms of immunosuppressive drugs on their therapeutic efficacy and safety have been poorly explored. This study was performed to investigate the influence of the PPP3CA c.249G>A variant on the clinical outcomes of kidney transplant recipients. Patients and methods: A total of 148 Brazilian patients received tacrolimus (TAC-based immunosuppressive therapy for 90 days post-kidney transplantation. The PPP3CA rs3730251 (c.249G>A polymorphism was determined by real-time polymerase chain reaction. Single-nucleotide polymorphism (SNP data for CYP3A5 rs776746 (CYP3A5*3C; g.6986A>G were used to eliminate the confounding effects of this variant. Results: The PPP3CA c.249G>A SNP did not influence early TAC exposure, renal function, or other laboratory parameters, including levels of urea, creatinine, glucose, and lipids, and blood counts. This variant also did not account for the cumulative incidence of biopsy-confirmed acute rejection or delayed graft function. Regarding adverse events, PPP3CA c.249A allele carriers initially had a 3.05-fold increased probability of treatment-induced blood and lymphatic system disorders compared with c.249GG genotype individuals (95% confidence interval: 1.10–8.48, p=0.032. However, this result was not maintained after adjusting for body weight and CYP3A5*3C SNP status (p=0.086. Conclusion: The PPP3CA c.249G>A variant does not influence the clinical outcomes of Brazilian patients in the

  16. CIL, II²/5, 316 (Igabrum y la cronología de los primeros flamines provinciales de la Bética

    Directory of Open Access Journals (Sweden)

    Goffaux, Bertrand

    2013-12-01

    Full Text Available A new reading is given for the CIL, II²/5, 316 inscription, from Igabrum (Cabra, Córdoba, based on a revision of the manuscript tradition. This manuscript gave the curriculum of a knight from Baetica, who had been praefectus fabrum, then military tribune in the legio VI Victrix, and then magistrate in the colonia Patricia, finally reaching the provincial flaminate. Such a career, including local honores after the sequence praefectura fabrum – military tribunate, is typical of the Augustan and Julio-Claudian period, which leads to a revision of the chronology of the document which could date back to the end of the Julio-Claudians, or the very beginning of the Flavian dynasty. Such a chronology raises questions about the origins of the provincial flaminate of Baetica, and about the commonly-accepted assumption that it was a Flavian creation.A partir de una revisión de la tradición manuscrita, se propone una nueva lectura de la inscripción CIL, II²/5, 316, de Igabrum (Cabra, Córdoba, que se refiere a la carrera de un caballero de la Bética. Su cursus hubiera incluido un nivel local, como magistrado de la colonia Patricia, después del ejercicio de la praefectura fabrum y del tribunado militar de la legio VI Victrix, y antes de su elección al flaminado provincial. La presencia de una función a nivel local, después de la sucesión praefectus fabrum – tribuno militar, es típica de los tiempos de Augusto o de los Julio-Claudios, y lleva a una revisión de la fecha del documento que podría colocarse al final de la época Julio-Claudia, o muy temprano en la época Flavia. Esta nueva cronología requiere interrogarse acerca de los orígenes del flaminado provincial de la Bética, y volver a examinar los criterios que llevaron a situar su creación bajo los emperadores Flavios.

  17. Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: role of multimodal analysis

    Directory of Open Access Journals (Sweden)

    Bruè C

    2013-01-01

    Full Text Available Claudia Bruè, Andrea Saitta, Michele Nicolai, Cesare Mariotti, Alfonso GiovanniniOphthalmology, Department of Neuroscience, Marche Polytechnic University, Ancona, ItalyBackground: The purpose of this study was to evaluate the role of spectral domain optical coherence tomography (SD-OCT, MP-1 microperimetry, and fundus autofluorescence imaging for planning surgical procedures in combined hamartomas of the retina and retinal pigment epithelium (CHR-RPE and following epiretinal membrane removal.Methods: In an interventional retrospective case series, six consecutive subjects with CHR-RPE underwent vitrectomy and epiretinal membrane peeling, with 4 years of follow-up. Each underwent complete ophthalmic examination, including best corrected visual acuity, fundus examination, fundus fluorescein angiography, SD-OCT, MP-1, and fundus autofluorescence at one, 6, 12, and 48 months.Results: Six eyes from six subjects with CHR-RPE were studied (mean age 31 ± 14 years. All patients were phakic and five were male (83.3%. Lesions were unilateral, ie, three macular, two juxtapapillary and macular, and one pericentral. Preoperative best corrected visual acuity was 0.3 ± 0.08 Snellen, with significant improvement to 0.9 ± 0.17 Snellen (P = 0.001 at 4 years of follow-up. Mean retinal sensitivity within the central 20° field improved from 16.6 ± 1.84 dB to 18.8 ± 0.96 dB (P = 0.07. There was also a statistically significant reduction in the visual defect (P = 0.04. SD-OCT demonstrated that the epiretinal membranes were completely removed in all but one patient, with significantly decreased macular edema on follow-up at one, 6, 12, and 48 months (P = 0.001. A positive correlation was shown between preoperative macular sensitivity and postoperative best corrected visual acuity. Fundus autofluorescence demonstrated a block in background autofluorescence at the site of the lesion, and hyperautofluorescsence at the edematous retina overlain by the epiretinal

  18. "A combined experimental and individual-differences investigation into mind wandering during a video lecture": Correction to Kane et al. (2017).

    Science.gov (United States)

    2018-04-01

    Reports an error in "A combined experimental and individual-differences investigation into mind wandering during a video lecture" by Michael J. Kane, Bridget A. Smeekens, Claudia C. von Bastian, John H. Lurquin, Nicholas P. Carruth and Akira Miyake ( Journal of Experimental Psychology: General , 2017[Nov], Vol 146[11], 1649-1674). In the article, the legends for Figure 2 and Figure 4 were erroneous. The correct figures are included in the errata. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2017-48585-001.) A combined experimental-correlational study with a diverse sample (N = 182) from 2 research sites tested a set of 5 a priori hypotheses about mind wandering and learning, using a realistic video lecture on introductory statistics. Specifically, the study examined whether students' vulnerability to mind wandering during the lecture would predict learning from, and situational interest in, the video and also whether longhand note-taking would help reduce mind wandering, at least for some students. One half of the participants took notes during the video, and all were subsequently tested on lecture content without notes. Regression and mediation analyses indicated that (a) several individual-differences variables (e.g., pretest score, prior math interest, classroom media multitasking habits) uniquely predicted in-lecture mind wandering frequency; (b) although the note-taking manipulation did not reduce mind wandering at the group level, note-taking still reduced mind wandering for some individuals (i.e., those with lower prior knowledge and those who took notes of high quality and quantity); (c) mind wandering uniquely predicted both learning (posttest) and situational interest outcomes above and beyond all other individual-differences variables; (d) moreover, mind wandering significantly mediated the effects of several individual differences; and, finally, (e) not all types of mind

  19. The impact of anesthesia providers on major morbidity following screening colonoscopies

    Directory of Open Access Journals (Sweden)

    Lubarsky DA

    2015-05-01

    Full Text Available David A Lubarsky,1 Jason R Guercio,2 John W Hanna,3,4 Maria T Abreu,5 Qianli Ma,3 Claudia Uribe,3 David J Birnbach,1,6 David R Sinclair,1 Keith A Candiotti1 1Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami – Miller School of Medicine, Miami, FL, USA; 2Department of Anesthesiology, Duke University, Durham, NC, USA; 3Humana, Comprehensive Health Insights, Miami, FL, USA; 4University of Miami – Miller School of Medicine, Miami, FL, USA; 5Department of Medicine, Division of Gastroenterology, University of Miami – Miller School of Medicine, Miami, FL, USA; 6Department of Public Health Sciences, University of Miami – Miller School of Medicine, Miami, FL, USA Background and aims: Few studies evaluate the impact of anesthesia providers during procedures, such as colonoscopy, on low-risk patients. The objective of this study was to compare the effect of anesthesia providers on several outcome variables, including major morbidity, following screening colonoscopies. Methods: A propensity-matched cohort study of 14,006 patients who enrolled with a national insurer offering health maintenance organization (HMO, preferred provider organization (PPO, and Medicare Advantage plans for a screening colonoscopy between July 1, 2005 and June 30, 2007 were studied. Records were evaluated for completion of the colonoscopy, new cancer diagnosis (colon, anal, rectal within 6 months of the colonoscopy, new primary diagnosis of myocardial infarction (MI, new primary diagnosis of stroke, hospital admission within 7 days of the colonoscopy, and adherence to guidelines for use of anesthesia providers. Results: The presence of an anesthesia provider did not affect major morbidity or the percent of completed exams. Overall morbidity within 7 days was very low. When an anesthesia provider was present, a nonsignificant trend toward greater cancer detection within 6 months of the procedure was observed. Adherence to national

  20. Management of Huntington’s disease: role of tetrabenazine

    Directory of Open Access Journals (Sweden)

    Marina de Tommaso

    2011-03-01

    Full Text Available Marina de Tommaso, Claudia Serpino, Vittorio SciruicchioNeurological and Psychiatric Sciences Department, University of Bari Aldo Moro, Bari, ItalyAbstract: Huntington’s disease (HD is an autosomal dominant neurodegenerative disorder characterized by progressive involuntary movements, neuropsychiatric disturbances, and cognitive impairment. The use of tetrabenazine (TBZ, a specific inhibitor of vesicular monoamine transporter, is approved for chorea in HD patients. We aimed to review the medical literature concerning the efficacy and tolerability of TBZ in the treatment of HD patients and to report our personal experience about TBZ use in a cohort of HD patients. We searched PubMed (1960 to July 2010 using the following keywords: “tetrabenazine” + “huntington’s disease + chorea”. We included randomized controlled trials, open-label trials, and retrospective studies. We excluded case reports and studies conducted on fewer than 20 patients. In addition, we retrospectively evaluated 2 years’ follow-up of TBZ treatment on motor and cognitive performances and functional abilities in 28 HD patients, compared with 10 patients treated by other neuroleptics (clotiapine. Only four papers fulfilled the requested criteria. In the first study, which included 84 randomized outpatients, TBZ showed a significant improvement of chorea compared with placebo. In the open-label study extension, TBZ confirmed its efficacy on chorea, with a frequent occurrence of withdrawals due to side effects. In a retrospective study of long-term efficacy, 63 patients under TBZ therapy for an average period of 34 months showed a stable effect on chorea, despite a slight reduction of effect over time. In a telephone survey conducted on a total of 118 patients affected by different movement disorders, TBZ showed the most favorable effect for the 28 included HD patients. Our HD patients showed a slight deterioration of motor performances over time that was

  1. Primera Jornada de Actualización en Patología Oral y Maxilofacial

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    Claudia Patricia Peña Vega

    2017-01-01

    Full Text Available Dedicamos las Lecturas recobradas a las memorias de la “Primera Jornada de Actualización en Patología Oral Y Maxilofacial” de las Facultades de Odontología y Medicina de la Universidad Nacional de Colombia, realizado en septiembre 30 al 01 de octubre del año 2016, bajo la coordinación de la profesora asociada del Departamento de Salud Oral de la universidad Nacional de Colombia, Claudia Patricia Peña Vega. El objetivo general del encuentro fue realizar una jornada académica integral de actualización en el campo de la Patología Oral y Maxilofacial dirigida a los estudiantes, residentes, egresados, profesores, y profesionales odontólogos, médicos, de las diferentes especialidades de interés en el área de la Patología General y Oral que fortalezcan la interdisciplinariedad del diagnóstico en un contexto clínico, académico e investigativo. Con el propósito de actualizar a los odontólogos y médicos en el estado del arte, avances tecnológicos y científicos en los diferentes campos de la Patología Oral y Maxilofacial, fortaleciendo académica y científicamente el campo de la Patología Oral y Maxilofacial, enmarcado como ámbito importante del conocimiento de la Patología General. Proporciona y difunde el Servicio de diagnóstico histopatológico en la Facultad de Odontología de la Universidad Nacional de Colombia. Todo esto, con el objetivo de crear un espacio académico para la presentación de casos clínicos y discusión de temas de interés, con la participación de diferentes expertos Patólogos de diferentes instituciones y creando nexos y vínculos académicos, hospitalarios y científicos con el Departamento de Patología de la Universidad Nacional de Colombia y la Sección Académica de Patología de la Faculta de Odontología de la Universidad Nacional de Colombia.

  2. Update on the role of eslicarbazepine acetate in the treatment of partial-onset epilepsy

    Directory of Open Access Journals (Sweden)

    Tambucci R

    2016-05-01

    Full Text Available Renato Tambucci,1 Claudia Basti,1 Maria Maresca,1 Giangennaro Coppola,2 Alberto Verrotti11Department of Pediatrics, University of L’Aquila, L’Aquila, Italy; 2Child and Adolescent Neuropsychiatry Unit, University of Salerno, Salerno, ItalyAbstract: Eslicarbazepine acetate (ESL is a once daily new third generation antiepileptic drug that shares the basic chemical structure of carbamazepine and oxcarbazepine – a dibenzazepine nucleus with the 5-carboxamide substituent, but is structurally different at the 10,11-position. ESL is a pro-drug metabolized to its major active metabolite eslicarbazepine. Despite the fact that the exact mechanism of action has not been fully elucidated, it is thought to involve inhibition of voltage-gated sodium channels (VGSC. ESL inhibits sodium currents in a voltage-dependent way by an interaction predominantly with the inactivated state of the VGSC, thus selectively reducing the activity of rapidly firing (epileptic neurons. ESL reduces VGSC availability through enhancement of slow inactivation. In Phase III studies, adjunctive therapy with ESL 800 or 1,200 mg/day leads to a significant decrease in the seizure frequency in adults with refractory partial onset epilepsy. Based on these results, ESL has been approved in Europe (by the European Medicines Agency and in the United States (by the US Food and Drug Administration as add-on therapy. Data on efficacy and safety have been confirmed by 1-year extension and real life observational studies. Recently, based on results from two randomized, double-blind, historical control Phase III trials, ESL received US Food and Drug Administration approval also as a monotherapy for patients with partial onset epilepsy. In the pediatric setting, encouraging results have been obtained suggesting its potential role in the management of epileptic children. Overall ESL was generally well tolerated. The most common adverse events were dizziness, somnolence, headache, nausea

  3. Anthroposophic therapy for asthma: A two-year prospective cohort study in routine outpatient settings

    Directory of Open Access Journals (Sweden)

    Harald J Hamre

    2009-11-01

    Full Text Available Harald J Hamre1, Claudia M Witt2, Gunver S Kienle1, Christof Schnürer3, Anja Glockmann1, Renatus Ziegler4, Stefan N Willich2, Helmut Kiene11Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany; 2Institute of Social Medicine, Epidemiology, and Health Economics, Charité University Medical Center, Berlin, Germany; 3Internal Medicine Practice, A Fraenkel Centrum, Badenweiler, Germany; 4Society for Cancer Research, Arlesheim, SwitzerlandBackground: Anthroposophic treatment for asthma includes special artistic and physical therapies and special medications.Methods: We studied consecutive outpatients starting anthroposophic treatment for asthma under routine conditions in Germany. Main outcomes were average asthma severity (0–10, primary outcome; symptoms (1–4; and asthma-related quality of life at 12-month follow-up (Asthma Quality of Life Questionnaire [AQLQ] overall score, 1–7, for adults; KINDL Questionnaire for Measuring Health-Related Quality of Life in Children and Adolescents, asthma module, 0–100, for children at 12-month follow-up.Results: Ninety patients (54 adults, 36 children were included. Anthroposophic treatment modalities used were medications (88% of patients, n = 79/90; eurythmy therapy (22%; art therapy (10%; and rhythmical massage therapy (1%. Median number of eurythmy/art/massage sessions was 12 (interquartile range 10–20, median therapy duration was 120 days (84–184. From baseline to 12-month follow-up, all outcomes improved significantly (P < 0.001 for all comparisons. Average improvements were: average asthma severity 2.61 points (95% confidence interval CI: 1.90–3.32; cough 0.93 (95% CI: 0.60–1.25; dyspnea 0.92 (95% CI: 0.56–1.28; exertion-induced symptoms 0.95 (95% CI: 0.64–1.25; frequency of asthma attacks 0.78 (95% CI:0.41–1.14; awakening from asthma 0.90 (95% CI: 0.58–1.21; AQLQ overall score 1.44 (95% CI:0.97–1.92; and KINDL asthma module 14.74 (95% CI: 9.70–19

  4. SFEN Annual Convention 2012 - The nuclear energy one year after Fukushima. Proceedings

    International Nuclear Information System (INIS)

    2012-03-01

    France (Philippe Girault, PricewaterhouseCoopers); 21 - Public acceptance, different sectors, identical behaviours (Claudia Gross, Resosens); 22 - Conclusion (Dominique Miniere, SFEN); Additional presentations: 23 - The Fukushima Daichi accident (Peter Volkholz, Areva NP GmbH); 24 - Impact on the public and on the environment (Philippe Renaud, IRSN)

  5. Early exposure to distinct sources of lipids affects differently the development and hepatic inflammatory profiles of 21-day-old rat offspring

    Directory of Open Access Journals (Sweden)

    Mennitti LV

    2018-01-01

    Full Text Available Laís Vales Mennitti,1 Lila Missae Oyama,2 Aline Boveto Santamarina,1 Claudia Maria da Penha Oller do Nascimento,2 Luciana Pellegrini Pisani3 1PhD Program ‘Interdisciplinar in Health Sciences’, Federal University of São Paulo (UNIFESP, Santos, SP, Brazil; 2Department of Physiology, Discipline of Nutrition Physiology, Federal University of São Paulo (UNIFESP, São Paulo, SP, Brazil; 3Department of Biosciences, Institute of Health and Society, Federal University of São Paulo (UNIFESP, Santos, SP, Brazil Introduction: Maternal diet composition of fatty acids during pregnancy and lactation seems to modify the fetal programming, epigenetic pattern and offspring phenotype. Aim: Herein, we investigated the effects of maternal consumption of normal-fat diets with distinct lipid sources during pregnancy and lactation on the somatic development and proinflammatory status of 21-day-old rat offspring. Materials and Methods: On the first day of pregnancy, female Wistar rats were divided into four groups as follows: soybean oil (M-SO, lard (M-L, hydrogenated vegetable fat (M-HVF and fish oil (M-FO. Diets were maintained during pregnancy and lactation. Male offspring constituted the SO, L, HVF and FO groups. Pups were weighed and measured weekly. Lipopolysaccharide serum concentration was determined. Tumor necrosis factor alpha, interleukin (IL-6 and IL-10 in the liver were evaluated by enzyme-linked immunosorbent assay. Liver gene expressions were determined by real-time polymerase chain reaction. Protein expressions in the liver were analyzed by Western blotting. Results: We observed an increase in body weight and adiposity in L and HVF groups. Moreover, HVF group showed an increase in the toll-like receptor 4 mRNA levels, IL10Rα and phosphorylated form of IκB kinase (IKK; p-IKKα+β protein expression. The FO group presented a decrease in body weight, relative weight of retroperitoneal adipose tissue, ADIPOR2 gene expression, lipopolysaccharide

  6. Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan–thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers

    Directory of Open Access Journals (Sweden)

    Ay Şenyiğit Z

    2015-10-01

    Full Text Available Zeynep Ay Şenyiğit,1 Sinem Yaprak Karavana,1 Derya İlem-Özdemir,2 Çağrı Çalışkan,2 Claudia Waldner,3 Sait Şen,4 Andreas Bernkop-Schnürch,5 Esra Baloğlu1 1Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Bornova, İzmir, Turkey; 2Faculty of Pharmacy, Department of Radiopharmacy, Ege University, Bornova, İzmir, Turkey; 3ThioMatrix, Forschungs-Beratungs GmbH, Innsbruck, Austria; 4Faculty of Medicine, Department of Pathology, Ege University, Bornova, İzmir, Turkey; 5Institute of Pharmacy, Department of Pharmaceutical Technology, University of Innsbruck, Innsbruck, AustriaAbstract: This study aimed to develop an intravesical delivery system of gemcitabine HCl for superficial bladder cancer in order to provide a controlled release profile, to prolong the residence time, and to avoid drug elimination via urination. For this aim, bioadhesive nanoparticles were prepared with thiolated chitosan (chitosan–thioglycolic acid conjugate and were dispersed in bioadhesive chitosan gel or in an in situ gelling poloxamer formulation in order to improve intravesical residence time. In addition, nanoparticle-loaded gels were diluted with artificial urine to mimic in vivo conditions in the bladder and were characterized regarding changes in gel structure. The obtained results showed that chitosan-thioglycolic acid nanoparticles with a mean diameter of 174.5±3.762 nm and zeta potential of 32.100±0.575 mV were successfully developed via ionotropic gelation and that the encapsulation efficiency of gemcitabine HCl was nearly 20%. In vitro/ex vivo characterization studies demonstrated that both nanoparticles and nanoparticle-loaded chitosan and poloxamer gels might be alternative carriers for intravesical administration of gemcitabine HCl, prolonging its residence time in the bladder and hence improving treatment efficacy. However, when the gel formulations were diluted with artificial urine, poloxamer gels lost their in

  7. Propagation Diagnostic Simulations Using High-Resolution Equatorial Plasma Bubble Simulations

    Science.gov (United States)

    Rino, C. L.; Carrano, C. S.; Yokoyama, T.

    2017-12-01

    In a recent paper, under review, equatorial-plasma-bubble (EPB) simulations were used to conduct a comparative analysis of the EPB spectra characteristics with high-resolution in-situ measurements from the C/NOFS satellite. EPB realizations sampled in planes perpendicular to magnetic field lines provided well-defined EPB structure at altitudes penetrating both high and low-density regions. The average C/NOFS structure in highly disturbed regions showed nearly identical two-component inverse-power-law spectral characteristics as the measured EPB structure. This paper describes the results of PWE simulations using the same two-dimensional cross-field EPB realizations. New Irregularity Parameter Estimation (IPE) diagnostics, which are based on two-dimensional equivalent-phase-screen theory [A theory of scintillation for two-component power law irregularity spectra: Overview and numerical results, by Charles Carrano and Charles Rino, DOI: 10.1002/2015RS005903], have been successfully applied to extract two-component inverse-power-law parameters from measured intensity spectra. The EPB simulations [Low and Midlatitude Ionospheric Plasma DensityIrregularities and Their Effects on Geomagnetic Field, by Tatsuhiro Yokoyama and Claudia Stolle, DOI 10.1007/s11214-016-0295-7] have sufficient resolution to populate the structure scales (tens of km to hundreds of meters) that cause strong scintillation at GPS frequencies. The simulations provide an ideal geometry whereby the ramifications of varying structure along the propagation path can be investigated. It is well known path-integrated one-dimensional spectra increase the one-dimensional index by one. The relation requires decorrelation along the propagation path. Correlated structure would be interpreted as stochastic total-electron-content (TEC). The simulations are performed with unmodified structure. Because the EPB structure is confined to the central region of the sample planes, edge effects are minimized. Consequently

  8. The Handbook of Medical Image Perception and Techniques

    Science.gov (United States)

    Samei, Ehsan; Krupinski, Elizabeth

    2014-07-01

    1. Medical image perception Ehsan Samei and Elizabeth Krupinski; Part I. Historical Reflections and Theoretical Foundations: 2. A short history of image perception in medical radiology Harold Kundel and Calvin Nodine; 3. Spatial vision research without noise Arthur Burgess; 4. Signal detection theory, a brief history Arthur Burgess; 5. Signal detection in radiology Arthur Burgess; 6. Lessons from dinners with the giants of modern image science Robert Wagner; Part II. Science of Image Perception: 7. Perceptual factors in reading medical images Elizabeth Krupinski; 8. Cognitive factors in reading medical images David Manning; 9. Satisfaction of search in traditional radiographic imaging Kevin Berbaum, Edmund Franken, Robert Caldwell and Kevin Schartz; 10. The role of expertise in radiologic image interpretation Calvin Nodine and Claudia Mello-Thoms; 11. A primer of image quality and its perceptual relevance Robert Saunders and Ehsan Samei; 12. Beyond the limitations of human vision Maria Petrou; Part III. Perception Metrology: 13. Logistical issues in designing perception experiments Ehsan Samei and Xiang Li; 14. ROC analysis: basic concepts and practical applications Georgia Tourassi; 15. Multi-reader ROC Steve Hillis; 16. Recent developments in FROC methodology Dev Chakraborty; 17. Observer models as a surrogate to perception experiments Craig Abbey and Miguel Eckstein; 18. Implementation of observer models Matthew Kupinski; Part IV. Decision Support and Computer Aided Detection: 19. CAD: an image perception perspective Maryellen Giger and Weijie Chen; 20. Common designs of CAD studies Yulei Jiang; 21. Perceptual effect of CAD in reading chest images Matthew Freedman and Teresa Osicka; 22. Perceptual issues in mammography and CAD Michael Ulissey; 23. How perceptual factors affect the use and accuracy of CAD for interpretation of CT images Ronald Summers; 24. CAD: risks and benefits for radiologists' decisions Eugenio Alberdi, Andrey Povyakalo, Lorenzo Strigini and

  9. FAIRNESS 2016 [4. workshop for young scientists with research interests focused on physics at FAIR (Facility for Antiproton and Ion Research), Garmisch-Partenkirchen (Germany), 14-19 Feb 2016

    International Nuclear Information System (INIS)

    2016-01-01

    physics at FAIR. June 2016, Organizers of FAIRNESS 2016: Marco Destefanis, Tetyana Galatyuk, Fernando Montes, Diana Nicmorus, Claudia Ratti, and Laura Tolos. (paper)

  10. Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury

    Directory of Open Access Journals (Sweden)

    Menk M

    2018-05-01

    Full Text Available Mario Menk, Jan Adriaan Graw, Clarissa von Haefen, Hendrik Steinkraus, Burkhard Lachmann, Claudia D Spies, David Schwaiberger Department of Anesthesiology and Operative Intensive Care Medicine, Charité – University Medicine Berlin, FreieUniversität Berlin, Humboldt-Universitätzu Berlin, and Berlin Institute of Health, Germany Purpose: Although the role of the angiotensin II type 2 (AT2 receptor in acute lung injury is not yet completely understood, a protective role of this receptor subtype has been suggested. We hypothesized that, in a rodent model of acute lung injury, stimulation of the AT2 receptor with the direct agonist Compound 21 (C21 might have a beneficial effect on pulmonary inflammation and might improve pulmonary gas exchange. Materials and methods: Male adult rats were divided into a treatment group that received pulmonary lavage followed by mechanical ventilation (LAV, n=9, a group receiving pulmonary lavage, mechanical ventilation, and direct stimulation of the AT2 receptor with C21 (LAV+C21, n=9, and a control group that received mechanical ventilation only (control, n=9. Arterial blood gas analysis was performed every 30 min throughout the 240-min observation period. Lung tissue and plasma samples were obtained at 240 min after the start of mechanical ventilation. Protein content and surface activity of bronchoalveolar lavage fluid were assessed and the wet/dry-weight ratio of lungs was determined. Transcriptional and translational regulation of pro- and antiinflammatory cytokines IL-1β, tumor necrosis factor-alpha, IL-6, IL-10, and IL-4 was determined in lungs and in plasma. Results: Pulmonary lavage led to a significant impairment of gas exchange, the formation of lung edema, and the induction of pulmonary inflammation. Protein content of lavage fluid was increased and contained washed-out surfactant. Direct AT2 receptor stimulation with C21 led to a significant inhibition of tumor necrosis factor-alpha and IL-6

  11. Lymphangiopathy in neurofibromatosis 1 manifesting with chylothorax, pericardial effusion, and leg edema

    Directory of Open Access Journals (Sweden)

    Finsterer J

    2013-09-01

    Full Text Available Josef Finsterer,1 Claudia Stollberger,2 Elisabeth Stubenberger,3 Sasan Tschakoschian4 1Krankenanstalt Rudolfstiftung, Vienna, Austria; 2Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria; 3Thoracic Surgery Department, Vienna, Austria; 4Interne Lungenabt, Vienna, Austria Background: This case report documents the affliction of the lymph vessels as a phenotypic feature of neurofibromatosis-1 (NF-1. Methodology: Routine transthoracic echocardiography, computed tomography scan of the thorax, magnetic resonance angiography of the renal arteries, and conventional digital subtraction angiography were applied. Comprehensive NF-1 mutation analysis was carried out by fluorescence in situ hybridization analysis, long-range reverse transcriptase polymerase chain reaction, and multiple-ligation probe assay. All other investigations were performed using routine, well-established techniques. Results: The subject is a 34-year-old, half-Chinese male; NF-1 was suspected at age 15 years for the first time. His medical history included preterm birth, mild facial dysmorphism, "café au lait" spots, subcutaneous and paravertebral fibromas, multifocal tachycardia, atrial fibrillation, and heart failure in early infancy. Noncalcified bone fibromas in the femur and tibia were detected at age 8 years. Surgical right leg lengthening was carried out at age 11 years. Bilateral renal artery stenosis, stenosis and aneurysm of the superior mesenteric artery, and an infrarenal aortic stenosis were detected at age 15 years. Leg edema and ectasia of the basilar artery were diagnosed at age 18 years. After an episode with an erysipela at age 34 years, he developed pericardial and pleural effusion during a 4-month period. Stenosis of the left subclavian vein at the level of thoracic duct insertion was detected. After repeated pleural punctures, pleural effusion was interpreted as chylothorax. Reduction of lymph fluid production by diet and injection of talcum into

  12. Targeting and treatment of glioblastomas with human mesenchymal stem cells carrying ferrociphenol lipid nanocapsules

    Directory of Open Access Journals (Sweden)

    Clavreul A

    2015-02-01

    Full Text Available Anne Clavreul,1 Angélique Montagu,2 Anne-Laure Lainé,2 Clément Tétaud,2 Nolwenn Lautram,2 Florence Franconi,3 Catherine Passirani,2 Anne Vessières,4 Claudia N Montero-Menei,2 Philippe Menei1 1Département de Neurochirurgie, Centre Hospitalier Universitaire, Angers, France; 2INSERM UMR-S 1066, Université d’Angers, LUNAM Université, Angers, France; 3CIFAB-PRIMEX, Université d’Angers, LUNAM Université, Angers, France; 4CNRS-UMR 7223, ENSCP, Paris, France Abstract: Recently developed drug delivery nanosystems, such as lipid nanocapsules (LNCs, hold great promise for the treatment of glioblastomas (GBs. In this study, we used a subpopulation of human mesenchymal stem cells, “marrow-isolated adult multilineage inducible” (MIAMI cells, which have endogenous tumor-homing activity, to deliver LNCs containing an organometallic complex (ferrociphenol or Fc-diOH, in the orthotopic U87MG GB model. We determined the optimal dose of Fc-diOH-LNCs that can be carried by MIAMI cells and compared the efficacy of Fc-diOH-LNC-loaded MIAMI cells with that of the free-standing Fc-diOH-LNC system. We showed that MIAMI cells entrapped an optimal dose of about 20 pg Fc-diOH per cell, with no effect on cell viability or migration capacity. The survival of U87MG-bearing mice was longer after the intratumoral injection of Fc-diOH-LNC-loaded MIAMI cells than after the injection of Fc-diOH-LNCs alone. The greater effect of the Fc-diOH-LNC-loaded MIAMI cells may be accounted for by their peritumoral distribution and a longer residence time of the drug within the tumor. These results confirm the potential of combinations of stem cell therapy and nanotechnology to improve the local tissue distribution of anticancer drugs in GB.Keywords: glioblastoma, mesenchymal stem cells, nanoparticle, drug delivery, targeting 

  13. Examining Motivations to Play Pokémon GO and Their Influence on Perceived Outcomes and Physical Activity.

    Science.gov (United States)

    Marquet, Oriol; Alberico, Claudia; Adlakha, Deepti; Hipp, J Aaron

    2017-10-24

    personal motivations and expectations when joining the game. These results highlight the importance of taking motivation into account when attempting to extract conclusions from the Pokémon GO phenomenon to enhance future exergames' designs or health interventions. ©Oriol Marquet, Claudia Alberico, Deepti Adlakha, J Aaron Hipp. Originally published in JMIR Serious Games (http://games.jmir.org), 24.10.2017.

  14. Highly efficient and compatible shampoo for use after hair transplant

    Directory of Open Access Journals (Sweden)

    Schweiger D

    2015-07-01

    Full Text Available Dorothea Schweiger,1 Andrea M Schoelermann,1 Alexander Filbry,1 Tina Hamann,1 Claudia Moser,2 Frank Rippke1 1Research and Development, Beiersdorf AG, Hamburg, Germany; 2Moser Medical, Clinics for Aesthetic Plastic Surgery, Vienna, Austria Background: Sensitive or hyperreactive skin is a common condition defined by prickling, burning, pain, and pruritus. Although this skin problem was initially described on the face, the scalp is often affected. A sensitive scalp can react with irritation to harsh surfactants or other additives which are often present in shampoos. For this reason, we developed a new rinse-off hypertolerant shampoo specifically designed for the hypersensitive and problematic scalp.Methods: The shampoo formulation is based on an extremely mild surfactant system and contains bisabolol, an anti-irritant and anti-inflammatory ingredient of chamomile. The shampoo is free of additives such as perfumes, silicones, colorants, parabens, paraffins, and betaine. Since skin can remain in a hyperreactive state after wounding, the status after hair transplantation was chosen as a model system to test the shampoo. Scalp condition and compatibility of each volunteer were analyzed by a plastic surgeon directly after hair transplant and after stitch removal. The plastic surgeons also rated whether they would recommend the further use of the test shampoo. Additionally, volunteers completed a self-assessment questionnaire.Results: Following hair transplantation, regular use of the shampoo resulted in a significant reduction in the extent of scabbing and erythema. This was confirmed by dermatological scalp examinations performed by the plastic surgeon as well as in volunteers' self-assessments. The plastic surgeon highly recommended the further use of the test shampoo after hair transplant to all study participants.Conclusion: Application of the test shampoo demonstrated excellent skin compatibility and product efficacy after hair transplant. The test

  15. Multimetallic Systems for the Photocatalytic Production of Fuels from Abundant Sources

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, Kim; Turro, Claudia [The Ohio State University

    2018-04-01

    The reported findings herein are a result of a collaboration between the groups of Claudia Turro at The Ohio State University (DE-SC0010542) and Kim R. Dunbar at Texas A&M University (DE-SC0010721). The Turro and Dunbar groups jointly discovered that cationic d7–d7 Rh2(II,II) complexes bridged by electron-donating formamidinate (form) ligands possess redox-active excited states that are relatively long-lived and can engage in charge transfer reactions. As part of the present grant we designed new complexes that exhibit strong absorption from the UV to ~800 nm. The Rh2(II,II) complexes under investigation are poised to undergo catalytic reduction of substrates because they are robust to changes in metal oxidation state, the two metals and the two diimine ligands, together with the non-innocent bridges, can be used to store redox equivalents, making these complexes capable of coupling one-electron events with multi-electron transformations. We discovered the electrocatalytic reduction of H+ and CO2 by complexes that are able to electrocatalytically reduce H+ to H2 with high turnover frequencies (TOFs) and overpotentials, η, of ~0.5 V,8 as well as to reduce CO2 to HCOOH. We now have experimental evidence that both the production of H2 from H+ and HCOOH. The molecular catalysts are stable after the acid and/or CO2 is consumed since electrocatalysis is restored at the same rate upon the addition of substrate to the cell.8,9 Moreover, we showed that the catalysis is not a result of a decomposition product deposited on the electrode, since placing an electrode from an active electrocatalytic solution into one that does not contain catalyst completely shuts down the reactivity. We are currently exploring the reactivity of these complexes in hydride transfer reactions with other substrates and in the presence of CO2 and reducing agents, as well as attempting to grow single crystals for x-ray diffraction.

  16. Synthesis, characterization, and in vitro activity against Candida spp. of fluconazole encapsulated on cationic and conventional nanoparticles of poly(lactic-co-glycolic acid

    Directory of Open Access Journals (Sweden)

    Gómez-Sequeda N

    2017-05-01

    Full Text Available Nicolás Gómez-Sequeda,1 Rodrigo Torres,2 Claudia Ortiz3 1School of Biology, 2School of Chemistry, Faculty of Sciences, 3School of Microbiology, Faculty of Health, Universidad Industrial de Santander, Bucaramanga, Santander, Colombia Abstract: In this study, nanoparticles (NPs of poly(lactic-co-glycolic acid (PLGA loaded with fluconazole (FLZ and FLZ-NPs coated with the cationic polymer polyethylenimine (PEI (FLZ-NP-PEI were synthetized in order to improve antimycotic activity against four strains of Candida spp. of clinical relevance. FLZ-NPs and FLZ-NP-PEI were synthesized by double emulsion solvent-diffusion (DES-D and characterized. Minimum inhibitory concentration (MIC50 and minimum fungicide concentration (MFC were determined in vitro by culturing Candida strains in the presence of these nanocompounds. FLZ-NPs were spherical in shape with hydrodynamic sizes of ~222 nm and surface charge of -11.6 mV. The surface charges of these NPs were successfully modified using PEI (FLZ-NP-PEI with mean hydrodynamic sizes of 281 nm and surface charge of 23.5 mV. The efficiency of encapsulation (~53% and a quick release of FLZ (≥90% after 3 h were obtained. Cytotoxicity assay showed a good cell viability for FLZ-NPs (≥86%, and PEI-modified NPs presented a decrease in cell viability (~38%. FLZ-NPs showed an increasing antifungal activity of FLZ for sensitive (Candida parapsilosis ATCC22019 and Candida albicans ATCC10231, MIC50 =0.5 and 0.1 µg/mL, respectively and resistant strains (Candida glabrata EMLM14 and Candida krusei ATCC6258, MIC50 =0.1 and 0.5 µg/mL, respectively. FLZ-NP-PEI showed fungicidal activity even against C. glabrata and C. krusei (MFC =4 and 8 µg/mL, respectively. MIC50 values showed best results for FLZ-NPs and FLZ-NP-PEI. Nevertheless, only FLZ-NP-PEI displayed fungicidal activity against the studied strains. Keywords: drug delivery systems, double emulsion diffusion, nanoparticles, minimal inhibitory concentration

  17. Revista História da Educação, v. 14, n. 30, 2010

    Directory of Open Access Journals (Sweden)

    RHE Asphe

    2011-03-01

    Full Text Available

    É com enorme satisfação que a revista História da Educação publicada pela Associação Sul Rio-Grandense de História da Educação - Asphe - trás á público mais um número de seu periódico. Sempre com a missão de divulgar trabalhos de investigadores nacionais e internacionais de renome na área de história da educação a comissão editorial deste número tem a certeza que mais uma vez tem o prazer de apresentar textos de excepcional qualidade.

    Abre este número o trabalho da professora Carlota Josefina Malta Cardozo dos Reis Boto: Compêndios pedagógicos de augusto coelho (1850-1925: a arte de tornar ciência o ofício de ensinar, no qual com brilhantismo a autora analisa a obra pedagógica deste renomado autor.

    A seguir, a professora Beatriz T. Daudt Fischer com o artigo Revista do Ensino/RS e Maria de Lourdes Gastal: duas histórias em conexão, analisa a revista mais consagrada da historiografia sobre educação do Rio Grande do Sul: a Revista do Ensino e a história de vida de Maria de Lourdes Gastal.

    Os dois textos seguintes decorrem da participação das professoras Ana Chrystina Venâncio Mignot e Claudia Alves no 14° Encontro de Pesquisadores de História da Educação do Rio Grande do Sul, realizado em 2009 no qual as referidas professoras participaram como conferencistas respectivamente com os trabalhos: Sobre coisas de outros tempos: rastros biográficos nas crônicas de Cecília Meireles na “página de educação” e Educação, memória e identidade: dimensões imateriais da cultura material escolar.

    A consagrada pesquisadora em História da Educação Mirian Jorge Warde juntamente com Claudia Panizzolo nos brindam com o texto as fontes do método analítico de leitura de João Köpke (1896-1917. Trabalho de altíssima qualidade e deve constituir de referência na área.

    Os professores portugueses Maria João Mogarro Fernanda Gon

  18. PREFACE: Young Researcher Meeting, Trieste 2014

    Science.gov (United States)

    Agostini, F.; Antolini, C.; Aversa, R.; Cattani, G.; Di Stefano, M.; Longobardi, M.; Martinelli, M.; Miceli, A.; Migliaccio, M.; Paci, F.; Pietrobon, D.; Pusceddu, E.; Stellato, F.

    2014-12-01

    skills. Engaging the public and finding unconventional ways to communicate results turn out to be real assets in improving the quality of presentation of current research to peers, as well as to the general public. In this volume, we collect part of the contributions that have been presented at the conference. They cover topics in astrophysics and cosmology, particle and theoretical physics, soft and condensed matter, medical physics and applied physics. Given the recent experimental achievements in particle physics and cosmology, several contributions were focused on the latest results obtained in these fields, presenting the impact of experiments such as LHC and Planck to the community of young researchers and forecasting the future goals in these areas of research. Particular interest was aroused by the session fully dedicated to applied Physics and conservation of cultural assets. Besides the intrinsic scientific value of the discussed topics, the increasing relative weight of the applied Physics session is a demonstration of the benefits that fundamental science brings to the community. YRM Organising and Editorial Committee Fabio Agostini (fabio.agostini31@gmail.com) Telespazio A Finmeccanica Thales Company Claudia Antolini (claudia.antolini@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati and Fudan University Rossella Aversa (raversa@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Giordano Cattani (giordano.cattani@gmail.com) Marco Di Stefano (distefan@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Maria Longobardi (marialongobardi@gmail.com) Department of Condensed Matter Physics, University of Geneva Matteo Martinelli (martinelli@thphys.uni-heidelberg.de) SISSA - Scuola Internazionale Superiore di Studi Avanzati and Institut fur Theoretische Physik Alice Miceli (alice.miceli@uniroma2.it) Physics Department, University of Rome Tor Vergata Marina Migliaccio (mm858@ast.cam.ac.uk) Institute of Astronomy and

  19. Five-year review of an international clinical research-training program

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    Suemoto CK

    2015-04-01

    Full Text Available Claudia Kimie Suemoto,1,2 Sherine Ismail,1,3 Paulo César Rodrigues Pinto Corrêa,1,4,5 Faiza Khawaja,1,6 Teodoro Jerves,1 Laura Pesantez,1 Ana Claudia Camargo Gonçalves Germani,1,7 Fabio Zaina,1,8 Augusto Cesar Soares dos Santos Junior,1,9,10 Ricardo Jorge de Oliveira Ferreira,1,11 Priyamvada Singh,1,12 Judy Vicente Paulo,1,13 Suely Reiko Matsubayashi,1,14 Liliane Pinto Vidor,1,15 Guilherme Andretta,1,16 Rita Tomás,1,17 Ben MW Illigens,1,18 Felipe Fregni1,18,19 1Collaborative Learning in Clinical Research Program, Principles and Practice of Clinical Research (PPCR, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 2Discipline of Geriatrics, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil; 3King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Pharmaceutical Care Department, King Khalid Hospital, NGHA, Jeddah, Saudi Arabia; 4Discipline of Internal Medicine and Medical Semiology, Department of Internal Medicine, Federal University of Ouro Preto (UFOP Medical School, Ouro Preto, Brazil; 5Discipline of Pneumology, Department of Internal Medicine, Centro Universitário de Belo Horizonte (Uni-BH, Belo Horizonte, Brazil; 6Canadian Centre for Advanced Eye Therapeutics, Mississauga, ON, Canada; 7Department of Preventive Medicine, University of São Paulo Medical School, São Paulo, Brazil; 8Italian Scientific Spine Institute (ISICO, Milan, Italy; 9Hospital Osvaldo Rezende Franco, Betim, Brazil; 10Nucleo de Avaliação de Tecnologia em Saude, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; 11Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 12Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA; 13Portuguese Institute of Oncology, Coimbra, Portugal; 14Acupuncture

  20. A gagueira sob diferentes olhares: análise comparativa das abordagens de quatro autoras Stuttering under different prisms: the comparative analysis based on four specialists

    Directory of Open Access Journals (Sweden)

    Rosivânia de Almeida Moraes

    2007-09-01

    Full Text Available OBJETIVO: analisar comparativamente quatro abordagens em gagueira quanto aos aspectos definição, etiologia, avaliação, terapia; demonstrar justificativas para a ausência de disfluências gagas no monólogo. MÉTODOS: revisão bibliográfica sistemática das publicações das autoras: Ana Maria Schiefer, Claudia Regina Furquim de Andrade, Silvia Friedman e Isis Meira, designadas como abordagens 1, 2, 3, 4. RESULTADOS: assemelham-se em: Definição - 1 e 2 quanto ao caráter descritivo, 2 e 3 quanto a auto-avaliação; Etiologia: 1, 2 e 4 quanto ao fator orgânico, 2, 3 e 4 quanto a implicação psicológica, 2 e 3 quanto a ambiental; Avaliação - 1 e 2 quanto ao critério quantitativo, 1, 2, 3 e 4 quanto ao qualitativo; Terapia - 1 e 2. A ausência de disfluências gagas se justificou pelas perspectivas: em 1, pressão do tempo e pragmática; em 2, ajuste neurolinguístico e motor; em 3, paradoxo básico, em 4, antecipação, ansiedade e medo. CONCLUSÃO: 1 e 2 se assemelham quanto definição, etiologia, avaliação, terapia; 1 e 3 quanto avaliação; 2 e 3 quanto definição, etiologia, avaliação; 1 e 4, 2 e 4, 3 e 4 quanto etiologia, avaliação, terapia. As semelhanças mostraram-se parciais, dada a especificidade do referencial teórico de cada abordagem. A ausência de disfluências gagas justificou-se pela inexistência da necessidade de ajuste ao interlocutor e de intenção comunicativa em 1, de ajuste na formulação lingüística e temporal em 2, pela ausência de receio de julgamento em 3, de antecipação, ansiedade e medo em 4.PURPOSE: this research is a comparative analysis between four different approaches on stuttering, by investigating the line of scientific thought of each author, definition, etiology, evaluation, therapy and raises some hypothesis to justify the absence of dysfluency in a monologue. METHODS: a systematic bibliographic revision of the authors' publications: Ana Maria Schiefer, Claudia Regina Furquim de

  1. Structure, function, and evolution of bacterial ATP-binding cassette systems

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, A.L.; Dassa, E.; Orelle, C.; Chen, J. (Purdue)

    2010-07-27

    The ATP-binding cassette (ABC) systems constitute one of the largest superfamilies of paralogous sequences. All ABC systems share a highly conserved ATP-hydrolyzing domain or protein (the ABC; also referred to as a nucleotide-binding domain [NBD]) that is unequivocally characterized by three short sequence motifs (Fig. 1): these are the Walker A and Walker B motifs, indicative of the presence of a nucleotide-binding site, and the signature motif, unique to ABC proteins, located upstream of the Walker B motif (426). Other motifs diagnostic of ABC proteins are also indicated in Fig. 1. The biological significance of these motifs is discussed in Structure, Function, and Dynamics of the ABC. ABC systems are widespread among living organisms and have been detected in all genera of the three kingdoms of life, with remarkable conservation in the primary sequence of the cassette and in the organization of the constitutive domains or subunits (203, 420). ABC systems couple the energy of ATP hydrolysis to an impressively large variety of essential biological phenomena, comprising not only transmembrane (TM) transport, for which they are best known, but also several non-transport-related processes, such as translation elongation (62) and DNA repair (174). Although ABC systems deserve much attention because they are involved in severe human inherited diseases (107), they were first discovered and characterized in detail in prokaryotes, as early as the 1970s (13, 148, 238, 468). The most extensively analyzed systems were the high-affinity histidine and maltose uptake systems of Salmonella enterica serovar Typhimurium and Escherichia coli. Over 2 decades ago, after the completion of the nucleotide sequences encoding these transporters in the respective laboratories of Giovanna Ames and Maurice Hofnung, Hiroshi Nikaido and colleagues noticed that the two systems displayed a global similarity in the nature of their components and, moreover, that the primary sequences of MalK and

  2. Nanoscaled hydrated antimony (V oxide as a new approach to first-line antileishmanial drugs

    Directory of Open Access Journals (Sweden)

    Franco AMR

    2016-12-01

    Full Text Available Antonia MR Franco,1 Iryna Grafova,2 Fabiane V Soares,1,3 Gennaro Gentile,4 Claudia DC Wyrepkowski,1,3 Marcos A Bolson,5 Ézio Sargentini Jr,5 Cosimo Carfagna,4 Markku Leskelä,2 Andriy Grafov2 1Laboratory of Leishmaniasis and Chagas Disease, National Institute of Amazonian Research (INPA, Manaus, Amazonas, Brazil; 2Department of Chemistry, University of Helsinki, Helsinki, Finland; 3Multi-Institutional Post-Graduate Program in Biotechnology, Federal University of Amazonas, Manaus, Amazonas, Brazil; 4Institute for Polymers, Composites, and Biomaterials, National Research Council, Pozzuoli, Naples Province, Italy; 5Laboratory of Environmental Chemistry, National Institute of Amazonian Research (INPA, Manaus, Amazonas, Brazil Background: Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V complexes are commercialized as sodium stibogluconate (Pentostam® and meglumine antimoniate (MA (Glucantime®. Ever-increasing drug resistance in the parasites limits the use of antimonials, due to the low drug concentrations being administered against high parasitic counts. Sb5+ toxicity provokes severe side effects during treatment. To enhance therapeutic potency and to increase Sb (V concentration within the target cells, we decided to try a new active substance form, a hydrosol of Sb2O5⋅nH2O nanoparticles (NPs, instead of molecular drugs. Methodology/principal findings: Sb2O5⋅nH2O NPs were synthesized by controlled SbCl5 hydrolysis in a great excess of water. Sb2O5⋅nH2O phase formation was confirmed by X-ray diffraction. The surface of Sb (V NPs was treated with ligands with a high affinity for target cell membrane receptors. The mean particle size determined by dynamic light scattering and transmission electron microscopy was ~35–45 nm. In vitro tests demonstrated a 2.5–3 times higher antiparasitic activity of Sb (V nanohybrid hydrosols

  3. Safety, tolerability, and efficacy of a fixed-dose combination of olmesartan 40 mg and hydrochlorothiazide 12.5/25 mg in daily practice

    Directory of Open Access Journals (Sweden)

    Bramlage P

    2013-08-01

    Full Text Available Peter Bramlage,1 Claudia Zemmrich,1 Reinhard Ketelhut,2 Wolf-Peter Wolf,3 Eva-Maria Fronk,4 Roland E Schmieder5 1Institut für Pharmakologie und Präventive Medizin, Mahlow, Germany; 2Institut für Sportmedizin, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Berlin, Germany; 3Daiichi Sankyo Deutschland GmbH, Munich, Germany; 4Daiichi Sankyo Europe GmbH, Munich, Germany; 5Universitätsklinikum Erlangen, Klinik für Nephrologie und Hypertensiologie, Erlangen, Germany Background: The safety and efficacy of olmesartan 40 mg and hydrochlorothiazide (HCTZ as a fixed-dose combination has been investigated in clinical trials leading to its approval. The aims of the present study were to confirm these data in an unselected patient population in daily practice and to determine the impact of physical activity on blood pressure control. Methods: In a multicenter, noninterventional study, 3,333 patients with either insufficient blood pressure control on olmesartan 40 mg alone or on a fixed/free combination of olmesartan 40 mg and HCTZ 12.5/25 mg were primarily assessed for safety and tolerability of the fixed-dose combination of olmesartan 40 mg and HCTZ 12.5/25 mg at 24 ± 2 weeks. Secondary objectives were blood pressure reduction, treatment compliance, and impact of physical activity as measured by the sum of weekly energy costs. Results: The mean patient age was 63.2 ± 11.46 years, mean baseline blood pressure was 159.6 ± 15.28/93.5 ± 9.52 mmHg, and 70.9% had at least one additional cardiovascular risk factor. Adverse drug reactions were rare (n = 19, and no serious adverse drug reactions occurred. Compliance with drug therapy was at least sufficient in more than 99% of patients at the end of the study. Blood pressure at the last available visit was reduced by 26.1 ± 15.5/13.0 ± 10.1 mmHg versus baseline (P < 0.0001, but had reduced effectiveness in patients ≥75 years with diabetes or impaired renal function. In 69% of patients

  4. Ruptured Pebbles - a coseismic and paleoseismic indicator?

    Science.gov (United States)

    Weismüller, Christopher; Reicherter, Klaus

    2017-04-01

    To increase the understanding of paleo-earthquakes and deformation patterns, and the propagation of surface waves in the proximity of active faults, we use the mainly disregarded features of ruptured or broken pebbles within in a clayey matrix. Deformation of unconsolidated sediments (alluvium, colluvium) due to earthquake ruptures is a long investigated topic, including the degradation of the fault scarp. However, during many trenching studies aligned pebbles along the fault planes have been described, and attributed to coseismic deformation. Over the last decades, we have found many ruptured pebbles in trenches at active faults with historic earthquakes, but also aligned (rotated?) pebbles. Here, we describe ruptured pebbles from a Pleistocene debris flow near the coastline between the towns Carboneras and Mojácar (SE Spain), East of the Sierra Cabrera. The outcrop is on-fault at the transition of the active Carboneras and Palomares faults (major historical earthquakes with M 7 in 1518 and 1522), implying proximity to the earthquakes epicenters. The Carboneras (NE-SW), Gafarillos (E-W) and Palomares (NNE-SSW) faults form major faults in eastern Andalucia. The outcrop contains ruptured pebbles in an only slightly consolidated, Pleistocene debris flow with 50 % matrix content. Similar near-fault ruptured pebbles have already been observed in the Carrizales quarry near Baelo Claudia, S Spain, and many other sites (e.g., Italy, Greece, Russia), but always in the proximity of active faults. We measured the fractures of 100 pebbles as planes, if possible, or trend, in case no measureable plane was accessible. Complementary 3D-models of the outcrop and each ruptured pebble were created using Structure from Motion, allowing us to further study the pebbles morphology and geometry. Mode II and conjugate fractures are prevailing in the pebbles and the lack of surface-loading such as striations and dissolution pits neglects clast-interaction. Un-cemented shear planes

  5. Blood pressure reactivity to mental stress is attenuated following resistance exercise in older hypertensive women

    Directory of Open Access Journals (Sweden)

    Gauche R

    2017-05-01

    Full Text Available Rafael Gauche,1 Ricardo M Lima,1,2 Jonathan Myers,2 André B Gadelha,1 Silvia GR Neri,1 Claudia LM Forjaz,3 Lauro C Vianna1 1Faculty of Physical Education, University of Brasília, Brasília, Brazil; 2Cardiology Division, Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, CA, USA; 3School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil Purpose: This study aimed to investigate the effects of resistance exercise (RE on autonomic control and blood pressure (BP reactivity during mental stress (MS in treated older hypertensive women. Methods: Ten older hypertensive women (age =71.1±5.5 years; body mass index =24.2±3.9; mean BP [MBP] =85.4±3.5 underwent a protocol consisting of BP and heart rate variability (HRV output assessments at baseline and during MS, and these measurements were taken before and 60 minutes after two bouts of RE (traditional and circuit. MS was induced through a computerized 3-minute Stroop color–word test before and 1 hour after each exercise session; BP was measured every minute during MS, and HRV was monitored as a measure of cardiac autonomic control. Results: A significant effect of time on systolic BP (∆pre =17.4±12.8 versus ∆post =12.5±9.6; P=0.01, diastolic BP (∆pre =13.7±7.1 versus ∆post =8.8±4.5; P=0.01, and MBP (∆pre =14.0±7.7 versus ∆post =9.3±5.4; P<0.01 after RE was observed, with no differences between the two sessions. In addition, a significant effect of time on log-normalized low-frequency component of HRV (ms2; 5.3±0.8 pre-exercise MS versus 4.8±1.0 baseline value; P=0.023 was also observed, showing a significant change from baseline to MS before RE, but not after RE sessions. These results may be related to a lessened RE-mediated cardiac sympathetic activity during MS. Conclusion: RE is an effective tool to reduce BP reactivity to MS, which could therefore be associated with an acute reduction in cardiovascular risk. This

  6. Novedades bibliográficas

    Directory of Open Access Journals (Sweden)

    Anuario Colombiano de Historia Social y de la Cultura

    2002-01-01

    . Pennsylvania:  Pennsylvania  Press University, 2000.  388, pp., ilustraciones, índices. /  Afrodesccndientes en las Américas: Travectorias sociales e identitarias. 150 años de la abolición de la esclavitud en Colombia. Claudia Mosquera, Mauricio Pardo y Odile Hüñmant (editores. Bogotá: UNAL-ICANH-IRD-ILSA, 2002. 61O pp .. gráficas e ilustraciones.

  7. Environmental Challenges Related to the Acquisition of the Trans Carpathian Wide Angle Reflection and Refraction Line

    Science.gov (United States)

    Dragut, Dorina-Alina; Schultz, Gehrig; Mocanu, Victor; Stephenson, Randell; Janik, Tomasz; Starostenko, Vitaly

    2015-04-01

    technological targets while managing to obey all legal rules and regulations imposed by the decision makers. We finally demonstrate that there is no danger for the environment by this classic form of seismic wave generation if all restrictions, health and safety rules are strictly complied with and are continuously monitored. This project could not be carried out successfully without significant support from: Mark Sturgess and Mark Wigley of Hunt Oil of Romania; Alex Stefan and Radita Bandrabur of Prospectiuni; Vasile Ionel Catana and Albert Ion Ranete of Maxam Romania; Alissa Ionescu of Lukoil Romania; Gheorghe Dutu, Claudia Raileanu and Elena Caramalau of the National Agency of Mineral Resources of Romania; Laszlo Klarick of the Romanian Senate. This work has been supported from the strategic grant POSDRU/159/1.5/S/133391, Project "Doctoral and Post-doctoral programs of excellence for highly qualified human resources training for research in the field of Life sciences, Environment and Earth Science" cofinanced by the European Social Fund within the Sectorial Operational Program Human Resources Development 2007 - 2013.

  8. Quality of life of young Chinese breast cancer patients after adjuvant chemotherapy

    Directory of Open Access Journals (Sweden)

    Yeo W

    2018-02-01

    Full Text Available Winnie Yeo,1,2 Frankie KF Mo,1,2 Elizabeth Pang,1,2 Joyce JS Suen,1 Jane Koh,1,2 Claudia HW Yip,1 Christopher CH Yip,1 Leung Li,1 Herbert HF Loong,1,2 Giok S Liem1 1Department of Clinical Oncology, Sir YK Pao Centre for Cancer, Prince of Wales Hospital, 2Hong Kong Cancer Institute, State Key Laboratory of Oncology in South China, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Introduction: Understanding of quality of life (QoL of young Chinese breast cancer patients after adjuvant cytotoxic chemotherapy is limited. This study aims to assess the QoL of premenopausal Chinese breast cancer women after receiving adjuvant chemotherapy.Patients and methods: Eligibility criteria included stage I–III breast cancer, premenopausal and age ≤45 years at cancer diagnosis and having received adjuvant chemotherapy within 3–10 years before entry to the present study. Patients’ background demographics at the time of breast cancer diagnosis, together with tumor characteristics and anticancer treatments, were collected. At the time of study entry, the menopausal status based on menstrual history, body mass index, and QoL (assessed using Functional Assessment of Cancer Therapy-Breast +4 were recorded.Results: Two hundred and eighty patients were recruited. Ninety-five patients (33.9% underwent breast-conserving surgery, and nearly all (98.6% underwent axillary dissection. For adjuvant therapies, 249 patients (88.9% received anthracycline-containing chemotherapy and 79 (28.2% received taxane-containing chemotherapy, while 68 (24.3% received both. One hundred and eighty six patients (66.4% received adjuvant radiotherapy, and 214 (76.4% received adjuvant tamoxifen. The median time from breast cancer diagnosis to study entry was 5.01 years. QoL assessment at study entry revealed that older patients had worse social well-being (SWB; mean scores for age ≤40, 41–45, 46–50 and >50 years were 22.0, 19.3, 19.1 and 18.1, respectively

  9. L-Moments Regional Frequency Analysis Methodology Application in maximum rainfall values over the Bogota River's basin

    Science.gov (United States)

    Romero, Claudia; Mesa, Duvan

    2015-04-01

    L-Moments Regional Frequency Analysis Methodology Application in maximum rainfall values over the Bogota River's basin 1°Claudia Patricia Romero Hernández; 2°Duvan Javier Mesa Fernández Universidad Santo Tomas; Colombia The application area of this methodology is the Bogota River's basin, which is located in Cundinamarca; a Colombian department with a total surface area of 589.143 hectares. This basin includes 19 sub-basins, and it is the most densely urbanized of the country. Including its metropolitan area, this region boasts a population of 9.000.000 inhabitants; which composes approximately 23% of Colombia's population and possesses around 19% of the country's industries. This basin has shown a notorious increase of complicated floods frequency in the last few years due to climatic variations. These climatic periods correspond to a weather pattern called Niña Phenomenon (2010-2011), which affected 57.000 citizens in this department and 4,900 people directly in Bogota city, with an estimated economic damage of 277'121,052 USD. The Regional Frequency Analysis methodology is a statistics procedure that consists in adding information from multiple samples in a single large sample, assuming previously that all of these come from the same probability model, except for a difference between them due to a scale factor. These samples are defined by a "regionalization" procedure known as the "Avenue Index" or "Flood Index". This procedure groups several kinds of information that comes from a common probability model, such as temperature, rainfall, and water flow. This model must be similar for all of the weather stations located in a homogeneous region. Maps for each of 4 return periods (5, 10, 50 and 100 years) were developed based on 120 weather stations located on this basin. The information used in this process comes from median monthly rainfall data, based on historical series between 30 and 40 years average. An increase in the annual median rainfall was

  10. Nurse home visits with or without alert buttons versus usual care in the frail elderly: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Favela J

    2013-01-01

    Full Text Available Jesús Favela,1 Luis A Castro,2 Francisco Franco-Marina,3 Sergio Sánchez-García,4 Teresa Juárez-Cedillo,4 Claudia Espinel Bermudez,4 Julia Mora-Altamirano,4 Marcela D Rodriguez,5 Carmen García-Peña41Center for Scientific Research and Higher Education of Ensenada, Ensenada, Baja California, Mexico; 2Sonora Institute of Technology, Ciudad Obregon, Mexico; 3National Institute of Respiratory Diseases, Mexican Ministry of Health, Mexico City, Mexico; 4Epidemiologic and Health Service Research Unit, Aging Area, XXI Century National Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; 5School of Engineering, MyDCI, Autonomous University of Baja California, Mexicali, MexicoObjective: To assess whether an intervention based on nurse home visits including alert buttons (NV+AB is effective in reducing frailty compared to nurse home visits alone (NV-only and usual care (control group for older adults.Design: Unblinded, randomized, controlled trial.Setting: Insured population covered by the Mexican Social Security Institute living in the city of Ensenada, Baja California, Mexico.Participants: Patients were aged over 60 years with a frailty index score higher than 0.14.Intervention: After screening and informed consent, participants were allocated randomly to the control, NV+AB, or NV-only groups.Measurements: The primary outcome was the frailty score 9 months later. Quality of life, depression, comorbidities, health status, and health service utilization were also considered.Results: The framing sample included 819 patients. Of those, 591 were not located because they did not have a landline/telephone (341 patients, they had died (107, they were ill (50, or they were not currently living in the city (28. A screening interview was applied to 228 participants, and 57 had a score ≤0.14, 171 had ≥0.14, and 16 refused to complete the baseline questionnaire. A home visit was scheduled for 155 patients. However, 22 did not complete

  11. Characterizing Active Ingredients of eHealth Interventions Targeting Persons With Poorly Controlled Type 2 Diabetes Mellitus Using the Behavior Change Techniques Taxonomy: Scoping Review.

    Science.gov (United States)

    Kebede, Mihiretu M; Liedtke, Tatjana P; Möllers, Tobias; Pischke, Claudia R

    2017-10-12

    explicit to avoid ambiguity. Response: Checked and avoided of a certain behavior Author: Please note that the journal discourages the use of parenthesis to denote either and/or and prefers to be explicit to avoid ambiguity. Response: Checked and avoided "and/or" and prefers to be explicit to avoid ambiguity. Response: Checked and avoided, and feedback on outcomes of behavior. Our results suggest that the majority of BCTs employed in interventions targeting persons with T2DM revolve around the promotion of self-regulatory behavior to manage the disease or to assist patients in performing health behaviors necessary to prevent further complications of the disease. Detailed reporting of the BCTs included in interventions targeting this population may facilitate the replication and further investigation of such interventions. ©Mihiretu M Kebede, Tatjana P Liedtke, Tobias Möllers, Claudia R Pischke. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 12.10.2017.

  12. Information and Communication Technologies in the Care of the Elderly: Systematic Review of Applications Aimed at Patients With Dementia and Caregivers.

    Science.gov (United States)

    Martínez-Alcalá, Claudia I; Pliego-Pastrana, Patricia; Rosales-Lagarde, Alejandra; Lopez-Noguerola, J S; Molina-Trinidad, Eva M

    2016-05-02

    applications through carrying out tests with patients with dementia and caregivers. The key finding of this systematic review revealed that the use of ICT tools can be strongly recommended to be used as a lifestyle in the elderly in order to improve the quality of life for the elderly and their primary caregivers. Since patients with AD are completely dependent in most activities, it is necessary to give attention to their primary caregivers to avoid stress and depression. In addition, the use of ICT in the daily life of caregivers can help them understand the disease process and manage situations in a way that is beneficial for both parties. It is expected that future developments concerning technological projects can support this group of people. ©Claudia I Martínez-Alcalá, Patricia Pliego-Pastrana, Alejandra Rosales-Lagarde, JS Lopez-Noguerola, Eva M Molina-Trinidad. Originally published in JMIR Rehabilitation and Assistive Technology (http://rehab.jmir.org), 02.05.2016.

  13. Bromfenac 0.09% bioavailability in aqueous humor, prophylactic effect on cystoid macular edema, and clinical signs of ocular inflammation after phacoemulsification in a Mexican population

    Directory of Open Access Journals (Sweden)

    Palacio C

    2016-01-01

    Full Text Available Claudia Palacio,1 Lourdes Fernández De Ortega,2 Francisco R Bustos,3 Eduardo Chávez,4 Aldo A Oregon-Miranda,5 Arieh R Mercado-Sesma5 1Anterior Segment Department, Fundación Hospital Nuestra Señora de la Luz, México City, México; 2Anterior Segment Department, Asociación Para Evitar la Ceguera en México, Hospital Dr Luis Sánchez Bulnes, México; 3Anterior Segment Department, Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México; 4Anterior Segment Department, Instituto de Oftalmología, Fundación de Asistencia Privada Conde de Valenciana, IAP, México; 5Clinical Research Department, Laboratorios Sophia, SA de CV, Zapopan, Jalisco, México Purpose: The purpose of this study was to evaluate the aqueous humor bioavailability and clinical efficacy of bromfenac 0.09% vs nepafenac on the presence of cystoid macular edema (CME after phacoemulsification.Material and methods: A Phase II, double-blind, masked, active-controlled, multicenter, clinical trial of 139 subjects, randomized to either a bromfenac 0.09% ophthalmic solution (n=69 or nepafenac 0.1% (n=70. Subjects instilled a drop three times a day for a period of 30 days. Follow-up visits were on days 2, 7, 15, 30, and 60. Biomicroscopy, clinical ocular signs, and assessment of posterior segment were performed. The primary efficacy endpoints included the presence of CME evaluated by optical coherence tomography. Safety evaluation included intraocular pressure, transaminase enzymes, lissamine green, and fluorescein stain.Results: The demographic and efficacy variables were similar between groups at baseline. The presence of pain, photophobia, conjunctival hyperemia, chemosis, cellularity, and corneal edema disappeared by day 30 in both groups. The central retinal thickness did not show significant changes after treatment when compared to baseline as follows: in the bromfenac group (247.2±32.9 vs 252.0±24.9 µm; P=0.958 and in nepafenac group (250.8±34

  14. Book reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2010-12-01

    Full Text Available The Atlantic World, 1450-2000, edited by Toyin Falola & Kevin D. Roberts (reviewed by Aaron Spencer Fogleman The Slave Ship: A Human History, by Marcus Rediker (reviewed by Justin Roberts Extending the Frontiers: Essays on the New Transatlantic Slave Trade Database, edited by David Eltis & David Richardson (reviewed by Joseph C. Miller "New Negroes from Africa": Slave Trade Abolition and Free African Settlement in the Nineteenth-Century Caribbean, by Rosanne Marion Adderley (reviewed by Nicolette Bethel Atlantic Diasporas: Jews, Conversos, and Crypto-Jews in the Age of Mercantilism, 1500-1800, edited by Richard L. Kagan & Philip D. Morgan (reviewed by Jonathan Schorsch Brother’s Keeper: The United States, Race, and Empire in the British Caribbean, 1937-1962, by Jason C. Parker (reviewed by Charlie Whitham Labour and the Multiracial Project in the Caribbean: Its History and Promise, by Sara Abraham (reviewed by Douglas Midgett Envisioning Caribbean Futures: Jamaican Perspectives, by Brian Meeks (reviewed by Gina Athena Ulysse Archibald Monteath: Igbo, Jamaican, Moravian, by Maureen Warner-Lewis (reviewed by Jon Sensbach Left of Karl Marx: The Political Life of Black Communist Claudia Jones, by Carole Boyce Davies (reviewed by Linden Lewis Displacements and Transformations in Caribbean Cultures, edited by Lizabeth Paravisini-Gebert & Ivette Romero-Cesareo (reviewed by Bill Maurer Caribbean Migration to Western Europe and the United States: Essays on Incorporation, Identity, and Citizenship, edited by Margarita Cervantes-Rodríguez, Ramón Grosfoguel & Eric Mielants (reviewed by Gert Oostindie Home Cooking in the Global Village: Caribbean Food from Buccaneers to Ecotourists, by Richard Wilk (reviewed by William H. Fisher Dead Man in Paradise: Unraveling a Murder from a Time of Revolution, by J.B. MacKinnon (reviewed by Edward Paulino Tropical Zion: General Trujillo, FDR, and the Jews of Sos

  15. Long-term outcome of laparoscopic and open surgery in patients with Crohn’s disease

    Directory of Open Access Journals (Sweden)

    Hoffmann M

    2017-11-01

    Full Text Available Martin Hoffmann,1 Dina Siebrasse,1 Erik Schlöricke,2 Ralf Bouchard,1 Tobias Keck,1 Claudia Benecke1 1Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, 2Department of Surgery, Westküstenklinikum Heide, Heide, Germany Aim: To investigate, via data analysis, the long-term outcome of patients who underwent either laparoscopic or open surgery for Crohn’s disease.Methods: A total of 113 patients who had undergone first abdominal surgery due to Crohn’s disease between January 2000 and December 2010 in a maximum care provider facility, were included in the statistical analysis. All patients provided their informed consent prior to inclusion. Data were collected from a database. Follow-up data included data from central mortality registries, general practitioners and a specialized clinic. Statistical analysis of the general patient data and the different operations and approaches were performed with the use of chi-square test, Fisher’s exact test, and the Mann–Whitney U test.Results: The median follow-up period in case of open and laparoscopic surgery was found to be 9 and 6 years, respectively. Statistically significant differences were observed for the following parameters in case of open and laparoscopic surgery, respectively: age (median=44 vs. 36 years, range=15–76 vs. 15–72 years; p=0.007, urgency of operation (23 out of 34 planned vs. 6 out of 70 planned; p<0.001, year of resection (median=2003 vs. 2006, range=2000–2010 vs. 2000–2010; p=0.001. The length of stay in hospital was significantly shorter in the laparoscopic group than that of open surgery group (8 vs. 11 days, respectively; p<0.0001. We did not control for factors such as age and comorbidities in our statistical analysis. We also did not find any differences with regard to perioperative and 90-day mortality, surgical complications, length of specimen, stoma, surgical recurrence rate (10% in both groups and number of re

  16. CoCo trial: Color-coded blood pressure Control, a randomized controlled study

    Directory of Open Access Journals (Sweden)

    Chmiel C

    2014-10-01

    Full Text Available Corinne Chmiel, Oliver Senn, Thomas Rosemann, Valerio Del Prete, Claudia Steurer-Stey Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland Background: Inadequate blood pressure (BP control is a frequent challenge in general practice. The objective of this study was to determine whether a color-coded BP booklet using a traffic light scheme (red, >180 mmHg systolic BP and/or >110 mmHg diastolic BP; yellow, >140–180 mmHg systolic BP or >90–110 mmHg diastolic BP; green, ≤140 mmHg systolic BP and ≤90 mmHg diastolic BP improves BP control and adherence with home BP measurement.Methods: In this two-group, randomized controlled trial, general practitioners recruited adult patients with a BP >140 mmHg systolic and/or >90 mmHg diastolic. Patients in the control group received a standard BP booklet and the intervention group used a color-coded booklet for daily home BP measurement. The main outcomes were changes in BP, BP control (treatment goal <140/90 mmHg, and adherence with home BP measurement after 6 months.Results: One hundred and twenty-one of 137 included patients qualified for analysis. After 6 months, a significant decrease in systolic and diastolic BP was achieved in both groups, with no significant difference between the groups (16.1/7.9 mmHg in the intervention group versus 13.1/8.6 mmHg in the control group, P=0.3/0.7. BP control (treatment target <140/90 mmHg was achieved significantly more often in the intervention group (43% versus 25%; P=0.037; number needed to treat of 5. Adherence with home BP measurement overall was high, with a trend in favor of the intervention group (98.6% versus 96.2%; P=0.1Conclusion: Color-coded BP self-monitoring significantly improved BP control (number needed to treat of 5, meaning that every fifth patient utilizing color-coded self-monitoring achieved better BP control after 6 months, but no significant between-group difference was

  17. Radiation Physics for Personnel and Environmental Protection

    International Nuclear Information System (INIS)

    Cossairt, J.D.

    1999-01-01

    The Fermi National Accelerator Laboratory FERMILAB- TM- 1834 Fermi National Accelerator Laboratory This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. This manuscript has been authored by Universities Research Association, Inc. under con- tract No. DE- ACO% 76CH03000 with the U. S. Department of Energy. The United States Government and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a nonexclusive, paid- up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for This text is dedicated to my wife Claudia, and our children, Joe and Sally, who provided me with love, cheerfulness, and their support during the long hours spent in the preparation of various versions of this text. I acknowledge the opportunity provided by the Fermilab Director, John Peoples, Jr., to be a part of the U. S. Particle Accelerator School. Also, the encouragement of Mel Month and A. Lincoln Read to teach in the USPAS has been sincerely appreciated. Several members of the Fermilab Environment, Safety and Health Section have greatly assisted me during the

  18. Clinical correlates of complicated grief among individuals with acute coronary syndromes

    Directory of Open Access Journals (Sweden)

    Pini S

    2015-10-01

    Full Text Available Stefano Pini,1 Camilla Gesi,1 Marianna Abelli,1 Alessandra Cardini,1 Lisa Lari,1 Francesca Felice,2 Rossella Di Stefano,2 Gianfranco Mazzotta,3 Francesco Bovenzi,4 Daniele Bertoli,5 Lucia Borelli,4 Paola Michi,1 Claudia Oligeri,3 Alberto Balbarini,2 Vijaya Manicavasagar6 1Department of Clinical and Experimental Medicine, Psychiatry Sector, University of Pisa, Pisa, 2Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, 3Unit of Cardiology, Ospedale Sant’Andrea, La Spezia, 4Cardio-Respiratory Department, Ospedale Campo di Marte, Lucca, 5Unit of Cardiology, Ospedale San Bartolomeo, Sarzana (SP, Italy; 6Black Dog Institute, University of New South Wales, Sydney, NSW, Australia Objective: The study aimed at exploring bereavement and complicated grief (CG symptoms among subjects without a history of coronary heart disease (CHD at the time of a first acute coronary syndrome (ACS and to evaluate the relationship of CG symptoms and ACS. Method: Overall, 149 subjects with ACS (namely, acute myocardial infarct with or without ST-segment elevation or unstable angina, with no previous history of CHD, admitted to three cardiac intensive care units were included and evaluated by the Structured Clinical Interview for Complicated Grief (SCI-CG, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and the 36-item Short-Form Health Survey (MOS-SF-36. Results: Of the total sample of 149 subjects with ACS, 118 (79.2% met criteria for DSM-5 persistent complex bereavement disorder. Among these, subjects who lost a partner, child, or sibling were older (P=0.008, less likely to be working (P=0.032, and more likely to be suffering from hypertension (P=0.021, returned higher scores on the SCI-CG (P=0.001 and developed the index ACS more frequently between 12 and 48 months after the death than those who lost a parent or another relative (P≤0.0001. The occurrence of ACS 12–48 months (P=0.019 after the loss was

  19. A cost-of-illness study of spina bifida in Italy

    Directory of Open Access Journals (Sweden)

    Colombo GL

    2013-07-01

    Full Text Available Giorgio L Colombo,1,2 Sergio Di Matteo,2 Marta Vinci,3 Claudia Gatti,4 Maria Paola Pascali,5 Mario De Gennaro,6 Elena Macrellino,7 Giovanni Mosiello,5 Tiziana Redaelli,7 Francesca Schioppa,7 Cristina Dieci8 1University of Pavia, Department of Drug Sciences, School of Pharmacy, Pavia, Italy; 2S.A.V.E. Studi Analisi Valutazioni Economiche, Milan, Italy; 3Associazione Walter Vinci Onlus, Milan, Italy; 4Centro Spina Bifida, Azienda Ospedaliera di Parma, Parma, Italy; 5Centro Spina Bifida, Ospedale Pediatrico Bambino Gesù, Rome, Italy; 6Ospedale Pediatrico Bambino Gesù, O.C. di Urodinamica, Rome, Italy; 7Centro Spina Bifida, Ospedale Niguarda Milan, Italy; 8ASBI Associazione Spina Bifida Italia, Piacenza, Italy Introduction: Spina bifida (SB is a congenital malformation of the spinal cord, nerves, and adjacent covering structures, with different levels of severity and functional disability. The economic cost of spina bifida and its prevention using folic acid have never been estimated in Italy. This study was conducted to define the cost of illness of SB in Italy. Methods: A retrospective multicenter observational study on the social cost of patients with SB was carried out in three SB centers in Italy. Cost data were collected relating to the 12 months preceding the enrollment time (T0, and subsequently 3 months after the T0 time (±20 days through a case report form designed to collect the relevant information on the costs incurred during the period considered. The data for all patients were analyzed through multivariate analysis on the main parameters. Results: We enrolled 128 patients equally divided between males and females, with a mean age of 13 years (minimum, 0; maximum, 29. Diagnosis was mostly postnatal, with 64 cases diagnosed at birth and 33 cases diagnosed subsequently. The lesion severity levels, as defined in the inclusion criteria, were walking (52 patients; walking with simple orthoses (33 patients; walking with complex orthoses

  20. Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities

    Directory of Open Access Journals (Sweden)

    Sanna V

    2014-10-01

    Full Text Available Vanna Sanna,1,2 Nicolino Pala,1 Giuseppina Dessì,1 Paola Manconi,1 Alberto Mariani,1 Sonia Dedola,3 Mauro Rassu,3 Claudia Crosio,3 Ciro Iaccarino,3 Mario Sechi1,2 1Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy; 2Laboratory of Nanomedicine, Department of Chemistry and Pharmacy, University of Sassari, c/o Porto Conte Ricerche, Tramariglio, Alghero, Italy; 3Department of Biomedical Sciences, University of Sassari, Sassari, Italy Background: Gold nanoparticles (GNPs are likely to provide an attractive platform for combining a variety of biophysicochemical properties into a unified nanodevice with great therapeutic potential. In this study we investigated the capabilities of three different natural polyphenols, epigallocatechin-3-gallate (EGCG, resveratrol (RSV, and fisetin (FS, to allow synergistic chemical reduction of gold salts to GNPs and stabilization in a single-step green process. Moreover, antioxidant properties of the nanosystems, as well as preliminary antiproliferative activity and apoptotic process investigation of model EGCG-GNPs on stable clones of neuroblastoma SH-SY5Y cells expressing CFP-DEVD-YFP reporter, were examined. Methods: The GNPs were characterized by physicochemical techniques, polyphenol content, and in vitro stability. The antioxidant activity of the GNPs was also determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid cation (ABTS radical-scavenging assays. Stable clones of neuronal SH-SY5Y-CFP-DEVD-YFP were generated and characterized, and cell viability after treatment with EGCG-GNPs was assessed after 72 hours through a 3(4,5-dimethylthiazol-2yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2H-tetrazolium assay. Activation of the apoptotic pathways was also investigated by Western blot analysis. Results: With a diameter in the size range of 10–25 nm, the obtained nanoparticles (NPs were found to contain 2.71%, 3.23%, and 5.47% of EGCG

  1. Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice

    Directory of Open Access Journals (Sweden)

    Dell’Osso B

    2015-07-01

    Full Text Available Bernardo Dell’Osso,1,2,* Umberto Albert,3,* Anna Rita Atti,4 Claudia Carmassi,5 Giuseppe Carrà,6 Fiammetta Cosci,7 Valeria Del Vecchio,8 Marco Di Nicola,9 Silvia Ferrari,10 Arianna Goracci,11 Felice Iasevoli,12 Mario Luciano,8 Giovanni Martinotti,13 Maria Giulia Nanni,14 Alessandra Nivoli,15,16 Federica Pinna,17 Nicola Poloni,18 Maurizio Pompili,19 Gaia Sampogna,8 Ilaria Tarricone,20 Sarah Tosato,21 Umberto Volpe,8 Andrea Fiorillo8 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Bipolar Disorders Clinic, Stanford Medical School, Stanford University, CA, USA; 3Rita Levi Montalcini Department of Neuroscience, University of Turin, Torino, 4Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK; 7Department of Health Sciences, University of Florence, Florence, 8Department of Psychiatry, University of Naples SUN, Naples, 9Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, 10Department of Diagnostic-Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Modena, 11Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, 12Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Federico II of Naples, Naples, 13Department of Neuroscience, Imaging, and Clinical Science, University G.d Annunzio, Chieti-Pescara, 14Section of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 15Psychiatric Institute, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy; 16Bipolar Disorder Unit, CIBERSAM, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain; 17Department of

  2. Committees and organizers

    Science.gov (United States)

    2011-07-01

    (Orsay) S Hamann (Bochum)R Varga (Košice) U Hannemann (Dresden)P Vavassori (San Sebastian) L Havela (Prague)W Wulfhekel (Karlsruhe) O Heczko (Prague)M Yamashita (Sendai) B Hernando (Oviedo)R Zdyb (Lublin) O Isnard (Grenoble)A Zhukov (San Sebastián) Z Kąkol (Kraków)A K Zvezdin (Moscow) N-T H Kim-Ngan (Kraków) International Advisory Committee (2011): Dominique Givord, President (Grenoble)Ludwig Schultz, Former President (Dresden) Manfred Albrecht (Chemnitz)Burkard Hillebrands (Kaiserslautern) Agnés Barthélémy (Paris)Andrei Kirilyuk (Nijmegen) Roy Chantrell (York)Ron Jansen (Tsukuba) Russell Cowburn (London)Nicoleta Lupu (Iasi) Tomasz Dietl (Warszawa)Caroline A Ross (Cambridge, MA) Claudia Felser (Mainz)Stefano Sanvito (Dublin) Josef Fidler (Wien)Vladimir Sechovsky (Praha) Dino Fiorani (Roma)Roberta Sessoli (Firenze) Pietro Gambardella (Bellaterra)Jozef Spałek (Kraków) Alberto Guimarães (Rio de Janeiro)

  3. PASCOS 2012 - 18th International Symposium on Particles Strings and Cosmology

    Science.gov (United States)

    2014-03-01

    (Sociedad Mexicana de Física), ICTP (International Centre for Theoretical Physics), BUAP (Benemérita Universidad Autónoma de Puebla), the Government of the State of Yucatán, the University of Hamburg, and Telmex. We also want to acknowledge the invaluable help of the staff of the Mexican Physical Society, in particular Lic. Santos Zúñniga Sánchez and Ms. Claudia Velasco Marín, and of the conference secretaries, Ms. Lizette Ramírez Bermúdez (UNAM) and Ms. Mariana del Castillo Sánchez (Cinvestav), for their support before, during and after the organization of PASCOS 2012. Last but not least, we would like to thank all the PASCOS 2012 participants for their attendance and for contributing to make the conference an engaging and stimulating event. The organizers, Myriam Mondragón, Adnan Bashir, David Delepine, Francisco Larios, Oscar Loaiza, Axel de la Macorra, Lukas Nellen, Sarira Sahu, Humberto Salazar and Liliana Velasco-Sevilla.

  4. Knowledge, Attitude, Behavior, and Practices Regarding HIV, Viral Hepatitis, and Sexually Transmitted Infections Among Migrants From Sub-Saharan Africa Living in Germany: A Multicenter Survey Protocol.

    Science.gov (United States)

    Santos-Hövener, Claudia; Koschollek, Carmen; Kuehne, Anna; Thorlie, Adama; Bremer, Viviane

    2017-05-02

    cities and to evaluate the application of participatory health research in epidemiological studies. First results are expected by the end of 2017. Working with peer researchers to collect data allowed accessibility to a diverse sample of MisSA and, particularly, allowed us to reach vulnerable subgroups, such as MisSA without legal status. The ability to access hard-to-reach groups is one of the big advantages of CBPHR. The active inclusion of the persons under study in the design of the study resulted in higher acceptance and ownership of the research project in the target community; this ultimately lead to better quality of collected data. Furthermore, the participation of MisSA in the development of study design and data collection assures a better understanding of the interests, needs, and living conditions of this group. ©Claudia Santos-Hövener, Carmen Koschollek, Anna Kuehne, Adama Thorlie, Viviane Bremer. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 02.05.2017.

  5. Sustentabilidade e Gestão de Empreendimentos Hoteleiros: Analisando Hotéis de Campo Grande, Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Maria Claudia Mancuelho Malta

    2015-10-01

    intensification of the diffusion of the concept, and the effective promotion of its implementation as a method of organizational management - helping in the process of encouraging the establishment of harmonious relations between the different economic activities, the environment, the culture and the other socio-spatial characteristics of the territories. Keywords: Tourism. Hotel Enterprises. Sustainability. Campo Grande, MS, Brazil. Maria Claudia Mancuelho Malta – Mestre. Professor da Escola Superior de Administração e Negócios da Universidade Federal de Mato Grosso de Sul, Campo Grande, MS, Curriclo Lattes: http://lattes.cnpq.br/6276197262789514. E-mail: minimalta@hotmail.com Milton Augusto Pasquotto Mariani – Doutor. Professor nos Programa de Mestrado em Administração e no Mestrado Profissional em Estudos Fronteiriços, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul. Currículo Lattes: http://lattes.cnpq.br/0935409945176042. E-mail: miltmari@terra.com.br Dyego de Oliveira Arruda – Mestre. É Professor do Centro Federal de Educação Tecnológica Celso Suckow da Fonseca (CEFET-RJ, Campus Valença, RJ. Currículo Lattes: http://lattes.cnpq.br/5222976964204691. E-mail: dyego.arruda@gmail.com

  6. Using the framework of corporate culture in “mergers” to support the development of a cultural basis for integrative medicine – guidance for building an integrative medicine department or service

    Directory of Open Access Journals (Sweden)

    Witt CM

    2015-01-01

    Full Text Available Claudia M Witt,1–3 Marion Pérard,2 Brian Berman,3,4 Susan Berman,4 Timothy C Birdsall,5 Horst Defren,6 Sherko Kümmel,7 Gary Deng,8 Gustav Dobos,9 Atje Drexler,10 Christine Holmberg,2 Markus Horneber,11 Robert Jütte,9 Lori Knutson,12 Christopher Kummer,13 Susanne Volpers,14 David Schweiger15 1University Hospital Zurich, Institute for Complementary and Integrative Medicine, Zurich, Switzerland; 2Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin, Berlin, Germany; 3University of Maryland School of Medicine, Center for Integrative Medicine, Baltimore, Maryland, USA; 4The Institute for Integrative Health, Baltimore, USA; 5Cancer Treatment Centers of America, Goodyear, Arizona, USA, 6Kliniken Essen Mitte, Evang, Huyssen-Stiftung/Knappschaft GmbH Patientenmanagement, Essen, Germany; 7Department of Senology, Breast Center, Kliniken Essen-Mitte, Evang. Huyssens Stiftung, Knappschaft GmbH, Essen, Germany; 8Memorial Sloan-Kettering Cancer Center, New York, USA; 9Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Academic Teaching Hospital of the University of Duisburg-Essen, Germany; 10Robert Bosch Foundation GmbH, Stuttgart, Germany; 11Department of Internal Medicine, Division of Oncology and Hematology, Paracelsus Medical University, Klinikum Nürnberg, Germany; 12Integrative Healthcare Solutions, Minneapolis, Minnesota, USA; 13Institute of Mergers, Acquisitions and Alliances (IMAA, Zurich, Switzerland; 14Frauenselbsthilfe nach Krebs, Bonn, Germany; 15Schweiger, Schweiger & Associates, Hilton Head Island, South Carolina, USA Background: An increasing number of clinics offer complementary or integrative medicine services; however, clear guidance about how complementary medicine could be successfully and efficiently integrated into conventional health care settings is still lacking. Combining conventional and complementary medicine into integrative medicine can be regarded as a kind of

  7. Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

    Directory of Open Access Journals (Sweden)

    Saúde ACM

    2014-10-01

    Full Text Available Amanda CM Saúde,1 Alicia S Ombredane,1 Osmar N Silva,1 João ARG Barbosa,1,2 Susana E Moreno,3 Ana Claudia Guerra Araujo,4 Rosana Falcão,4 Luciano P Silva,4 Simoni C Dias,1 Octávio L Franco1,3 1Programa de Pós Graduação em Ciências Genômicas e Biotecnologia, Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brasília, FD, Brazil; 2Laboratório de Biofísica-Departamento de Biologia Celular-IB, Universidade de Brasília – UNB, DF, Brazil; 3Universidade Católica Dom Bosco – UCDB, Campo Grande, MS, Brazil; 4Empresa Brasileira de Pesquisa Agropecuária – EMBRAPA – Recursos Genéticos e Biotecnologia, Brasília, DF, Brazil Abstract: Controlling human pathogenic bacteria is a worldwide problem due to increasing bacterial resistance. This has prompted a number of studies investigating peptides isolated from marine animals as a possible alternative for control of human pathogen infections. Clavanins are antimicrobial peptides isolated from the marine tunicate Styela clava, showing 23 amino acid residues in length, cationic properties, and also high bactericidal activity. In spite of clear benefits from the use of peptides, currently 95% of peptide properties have limited pharmaceutical applicability, such as low solubility and short half-life in the circulatory system. Here, nanobiotechnology was used to encapsulate clavanin A in order to develop nanoantibiotics against bacterial sepsis. Clavanin was nanostructured using EUDRAGIT® L 100-55 and RS 30 D solution (3:1 w:w. Atomic force, scanning electron microscopy and dynamic light scattering showed nanoparticles ranging from 120 to 372 nm in diameter, with a zeta potential of -7.16 mV and a polydispersity index of 0.123. Encapsulation rate of 98% was assessed by reversed-phase chromatography. In vitro bioassays showed that the nanostructured clavanin was partially able to control development of Staphylococcus aureus, Klebsiella pneumoniae, and

  8. La política en los intelectuales, retrospectiva crítica

    Directory of Open Access Journals (Sweden)

    Leonardo Martín Candiano

    2015-06-01

    Full Text Available El artículo "La política en los intelectuales, retrospectiva crítica" pretende relevar el largo recorrido de la crítica nacional respecto de los debates en torno al rol del intelectual durante los rebeldes años sesenta en la Argentina en particular y en América Latina en general, a partir del análisis y puesta en diálogo de una serie de estudios focalizados en dicha problemática. De los múltiples trabajos existentes al respecto, retomo los libros Nuestros años sesenta (1991, de Oscar Terán; Intelectuales y poder en la década del sesenta (1991, de Silvia Sigal; Entre la pluma y el fusil, debates y dilemas del intelectual revolucionario en América Latina (2003, de Claudia Gilman; e Intelectuales y violencia política. 1955-1973 (2010, de Pablo Ponza. A su vez, rescato los artículos “El boom en perspectiva” (1979, de Ángel Rama, “Pareceres y disgresiones en torno a la nueva narrativa latinoamericana” (1984, de David Viñas,  “Intelectuales: ¿escisión o mímesis?” (1985, de Beatriz Sarlo y “La irrupción de la crítica. Introducción” (1999, de Susana Cella. A pesar de no focalizarse en la politización del intelectual, el trabajo de Victoria Cohen Imach De utopías y desencantos. Campo intelectual y periferia en la Argentina de los sesenta (1994 funciona como complemento que permite enriquecer la mirada sobre las características peculiares del problema. Asimismo,  los estudios que se articulan alrededor de las distintas vertientes del desarrollo del marxismo en el país y en el continente, como La cola del diablo, itinerario de Gramsci en América Latina (1988, de José Aricó, “El corpus marxista” (1999, de Horacio Tarcus y los artículos de Néstor Kohan “La rosa blindada, una pasión de los ´60. Estudio introductorio” (1999 y “Pensamiento Crítico y el debate por las ciencias sociales en el seno de la revolución cubana” (2006, nos orientan en los debates y las influencias fundamentales de la

  9. Anaerobic digestion of solid biomass and biowaste

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Within the International Trade Fair for Biogas Plant Technology from 23rd to 24th February, 2012 in Berlin, the following lectures were held: (1) Presentation and results of the EU project 24biomass'' (Claudia Lutsyuk); (2) The Polish biogas market (Tomasz Surowiec); (3) Presence and future of the biogas sector in Poland - EBE project (Eugeniusz Jedrysik); (4) Modern biogas generation in Poland - Case studies of the company Poldanor (Jens Bo Holm-Nielsen); (5) Low space requirement - The challenge in the integration of biogas plants in existing composting facilities - examples from real life (Michael Oertig); (6) Integration of biogas plants in composting facilities by partial-flow fermentation (Bruno Mattheeuws); (7) The significance of an efficient removal of foreign matter from biomass before fermentation in a waste incinerator for municipal wastes (Stephan Schulte); (8) Sustainable enhancement of the anaerobic degradation and increase of the biogas production by means of ultrasonic treatment - examples from real life (Silvana Velten); (9) Cultivation of energy plants on sandy soils in the northeastern part of Germany (Gunter Ebel); (10) Topinambur, a new sustainable energy crop for biogas generation (Vito Pignatelli); (11) Potential of biogas generation from reed (Vilis Dubrovskis); (12) Biogas generation from maize straw - a new procedure of harvesting and processing (Thomas Amon); (13) Generation of biogas by cofermentation of pig manure and grass silage: a pilot study (Ximmin Zhan); (14) Thermophilic dry fermentation of poultry litter and energy crops for the generation of biogas, organic fertilizer and protection of water resources from environmental damages in the Mid-Atlantic region of the USA (John Intersoll); (15) Energetic utilisation of horse manure (Saskia Oldenburg); (16) Realization of the greatest and most modern Hungarian biogas plant in Szarvas (Ludwig Dinkloh); (16) Biogas in Russia - The investment program of the cooperation &apos

  10. 6th International Symposium on Molecular Allergology (ISMA

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    Christiane Hilger

    2016-10-01

    -patient quantification of allergen-specific IgE Petra Zavadakova, Aurélie Buchwalder, Fabien Rebeaud, Iwan Märki Symposium 4: Relevance of molecular diagnostics for intervention and treatment O7 Longitudinal analysis of Bet v 1-specific epitope repertoires during birch pollen immunotherapy Barbara Gepp, Nina Lengger, Christian Möbs, Wolfgang Pfützner, Christian Radauer, Barbara Bohle O8 A natural CCD-free tool: is polistes sp. venom suitable for polybia paulista diagnosis and therapy? Karine Marafigo De Amicis, Alexandra Sayuri Watanabe, Clovis Eduardo Galvao, Daniele Danella Figo, Jose Roberto Aparecido Santos-Pinto, Mario Sergio Palma, Fabio Fernandes Morato Castro, Jorge Kalil, Fatima Ferreira, Gabriele Gadermaier, Keity Souza Santos Symposium 5: The advent of molecular allergology in epidemiology O9 Peanut oleosins: from identification to diagnostic testing Christian Schwager, Skadi Kull, Frauke Schocker, Jochen Behrends, Wolf-Meinhard Becker, Uta Jappe O10 Endotypes of oral allergy syndrome in childhood: a molecular diagnostic approach Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Riccardo Asero, Arianna Dondi, Giampaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Andrea Di Rienzo Businco, Annamaria Bianchi, Tullio Frediani, Carmen Verga, Iride Dello Iacono, Diego Peroni, Giuseppe Pingitore, Roberto Bernardini, Paolo Maria Matricardi Symposium 6: Molecular AIT: which approaches will make it to market? O11 Mbc4: an innovative molecule to tackle birch pollen and concomitant food allergies Heidi Hofer, Claudia Asam, Michael Hauser, Peter Briza, Martin Himly, Christof Ebner, Fatima Ferreira O12 Challenges and solutions associated with the production of recombinant Bet v 1 allergen as a therapeutic protein Emmanuel Nony, Maxime Le Mignon, Pierrick Lemoine, Karine Jain, Kathy Abiteboul, Monica Arvidsson, Sabina Rak, Philippe Moingeon Clinical Cases: Breakthroughs and headaches from CRD: interactive session CC1 Anaphylaxis caused by lipid transfer proteins: a

  11. Editorial

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    Irene Machado

    2008-11-01

    Full Text Available As preocupações teóricas que, há dois anos, deflagraram o projeto editorial de Galáxia foram tematizados sob vários pontos de vista nesse número. Desde sua primeira edição, a revista vem defendendo a noção de transdisciplinaridade, seja como forma de abordagem dos diferentes fenômenos da cultura, seja como tema mesmo de várias das intervenções teóricas nela abrigadas. Privilegiar o trânsito entre disciplinas e abordagens, porém, não é um exercí­cio acadêmico. Traduz a compreensão que orienta a abordagem semiótica no tratamento dos produtos da cultura planetária, de suas formas comunicacionais e artí­sticas totalmente mergulhadas nas chamadas novas tecnologias (sistemas digitais, ambientes de rede, realidade virtual, bem como de suas comunidades multiculturais. O exercí­cio transdisciplinar pareceu-nos uma estratégia fundamental para o tratamento de problemas postos na cultura graças ao arrefecimento entre dicotomias ou campos tidos como oponentes. A discussão sobre as relações entre mí­dia e arte inserem-se, com ênfase, nesse novo contexto. Esse é um dos temas inquietantes que está na mente dos pesquisadores e, por isso mesmo, organizou a pauta de discussão deste quarto número de Galáxia. Alguns enfrentamentos sobre o encontro entre arte e mí­dia foram apresentados nos ensaios que compõem o fórum. A intervenção de Arlindo Machado convida o leitor a desfazer equí­vocos: não existe arte que possa prescindir dos meios de seu tempo. Evidentemente sua fala traduz uma linha vigorosa de seu pensamento: a impossibilidade de se pensar comunicação fora do diálogo com as artes e suas linguagens. Ana Claudia de Oliveira enfrentou a tarefa de análise de produções artí­sticas realizadas com os meios e mí­dias de seu tempo para dar conta de um problema caro à comunicação: as estratégias de interação. Embora o foco de seu interesse seja a arte contemporânea, suas idéias confrontam

  12. Editorial: Qualitative Forschung in der Medienpädagogik

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    Horst Niesyto

    2008-01-01

    Darstellung von Surfwegen im Internet» ein methodisches Instrument vor, das die Autorin nicht als ein technisch komplexes und ‹objektive› Daten lieferndes Methodeninstrumentarium, sondern als eine ergänzende Methode versteht. Gegenstand ihres Forschungsprojekts ist der medienkonvergente Umgang von Jugendlichen mit in Deutschland empfangbaren Musikkanälen und den dazugehörigen Internetseiten. In der Verknüpfung von thematisch fokussierten Interviews (mit erzählgenerierenden Eingangsfragen und gemeinsamen Surfen im Internet (in Verbindung mit der Methode des «lauten Denkens» werden Daten erhoben und anschliessend im Rahmen einer «doppelten Rekonstruktion» ausgewertet. Diese Rekonstruktion umfasst die grafische Visualisierung des Surfwegs der befragten Nutzer/innen. Der Beitrag illustriert das methodische Vorgehen anhand von zwei Beispielen. An der Schnittstelle zwischen mediendidaktischen und schulbezogenen Beiträgen argumentieren die drei Beiträge von Kerstin Mayrberger, Renate Schulz-Zander und Birgit Eickelmann und Claudia Zentgraf u. a. Sie zeigen ein breites Spektrum von möglichen Zugängen zum Schulfeld bzw. zur Erforschung von Schulentwicklungsprozessen aus der Perspektive qualitativer Forschung auf. Renate Schulz-Zander und Birgit Eickelmann gehen von den Ergebnissen der internationalen und nationalen qualitativen IEA-Studie SITES Modul 2 aus und beschreiben nach einem ausführlichen Projektaufriss die Folgeuntersuchung zu SITES M2 eine qualitative und quantitative Studie auf der Basis von Fallstudien. Ziel der Studie ist es, mit den Erhebungsinstrumenten sowohl den Entwicklungsprozess zu rekonstruieren wie die erforderlichen Informationen über den Grad der Nachhaltigkeit der Implementierung zu liefern. In der Anlage verbindet das Projekt quantitative und qualitative Methoden, indem leitfadengestützte Interviews, problemzentrierte Interviews und standardisierte Befragungen mit Fragebögen kombiniert werden. Claudia Zentgraf u. a. fordern in ihrem

  13. Editorial

    Directory of Open Access Journals (Sweden)

    Márcio Matias

    2012-01-01

    Garcia Rosa. Além disto, esta edição também apresenta trabalhos sobre diversos aspectos ligados à comunicação científica, tais como qualidade, visibilidade, indicadores de gestão de fluxo editorial, curadoria digital, repositórios e preservação digital, que são listados a seguir: Metadados de qualidade e visibilidade na comunicação científica, de Silvia Maria Puentes Bentancourt e Rafael Port da Rocha; Indicadores de gestão do fluxo editorial dos periódicos científicos: uma reflexão teórico-metodológica, deElisabete Werlang, Daniela Spudeit e Nadi Helena Presser; O impacto da curadoria digital dos dados de pesquisa na Comunicação Científica de Luana Farias Sales e Luís Fernando Sayão; Análise da dinâmica de evolução das revistas científicas e bibliotecas digitais de teses e dissertações em acesso livre na área de Ciências da Comunicação: o caso do repositório Univerciencia.org, deDalton Lopes Martins e Sueli Mara Soares Pinto Ferreira; Acesso livre via repositórios: politicas de instituições brasileiras, de Tania Chalhub , Alegria Benchimol e Claudia Guerra; O papel das bibliotecas universitárias na comunicação científica: um estudo sobre os repositórios institucionais, de Patrícia dos Santos Caldas Marra; Acesso Livre à Informação Científica em Países em Desenvolvimento: o caso dos Repositórios “Saber” (Moçambique e Digital da UFMG (Brasil, de Ranito Zambo Waete, Maria Aparecida Moura, e Manuel Valente Mangue; SEER e PDF/A na preservação de revistas científicas: relato de experiência, de Ana Paula Araújo Cabral da Silva; Ontologia de dependência tecnológica de documentos digitais: Instrumento de Apoio à Preservação Digital, de Eloi Juniti Yamaoka e Fernando Ostuni Gauthier. Vale também destacar a nossa bela capa gentilmente elaborada pelo professor Adilson Luiz Pinto. Ótima leitura! Márcio Matias e Moisés Lima Dutra Editores – Edição Especial – 3º SBCC – Perspectivas em Acesso Aberto

  14. Editorial Editorial

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    José Luiz Aidar Prado

    2008-11-01

    Janotti e Thiago Soares desdobram a metodologia de análise midiática publicidade dita "contra-intuitiva" numa peça publicitária da Fiat. Carolina Sá-Carvalho e Maurício Lissovsky examinam em fotografias as transformações do sofrimento e da dor. Adriana Stürmer e Ada Machado abordam uma série televisiva para estudar produções de sentido identitário de narrativas sobre imigrantes. Maria Lucia Vissoto encara o acontecimento na reportagem jornalística, considerando a questão da tensividade, a partir da semiótica greimasiana. As resenhas desvendam três livros: Cintia dal Bello apresenta O show do eu: a intimidade como espetáculo, de Paula Sibilia, que deve sair em breve, para explicitar a espetacularização do eu em rede; Fernando Resende explica os rumos da coletânea metodologia da pesquisa em jornalismo, organizada por Claudia Lago e Marcia Benetti, que acaba de sair em segunda edição, nem um ano depois de seu lançamento; Laurindo Lalo Leal Filho destrincha políticas de comunicação: buscas teóricas e práticas, coletânea organizada por Murilo Ramos e Suzy dos Santos sobre as políticas de comunicação no país. José luiz Aidar Prado Editor

  15. Editorial

    Directory of Open Access Journals (Sweden)

    Márcio Matias

    2012-12-01

    . Susane Santos Barros, Flávia Goulart Mota Garcia Rosa. Além disto, esta edição também apresenta trabalhos sobre diversos aspectos ligados à comunicação científica, tais como qualidade, visibilidade, indicadores de gestão de fluxo editorial, curadoria digital, repositórios e preservação digital, que são listados a seguir: Metadados de qualidade e visibilidade na comunicação científica, de Silvia Maria PuentesBentancourt e Rafael Port da Rocha; Indicadores de gestão do fluxo editorial dos periódicos científicos: uma reflexão teórico-metodológica, deElisabete Werlang, Daniela Spudeit e Nadi Helena Presser; O impacto da curadoria digital dos dados de pesquisa na Comunicação Científica de Luana Farias Sales e Luís Fernando Sayão; Análise da dinâmica de evolução das revistas científicas e bibliotecas digitais de teses e dissertações em acesso livre na área de Ciências da Comunicação: o caso do repositório Univerciencia.org, deDalton Lopes Martins e Sueli Mara Soares Pinto Ferreira; Acesso livre via repositórios: politicas de instituições brasileiras, de Tania Chalhub , Alegria Benchimol e Claudia Guerra; O papel das bibliotecas universitárias na comunicação científica: um estudo sobre os repositórios institucionais, de Patrícia dos Santos Caldas Marra; Acesso Livre à Informação Científica em Países em Desenvolvimento: o caso dos Repositórios “Saber” (Moçambique e Digital da UFMG (Brasil, de Ranito Zambo Waete, Maria Aparecida Moura, e Manuel Valente Mangue; SEER e PDF/A na preservação de revistas científicas: relato de experiência, de Ana Paula Araújo Cabral da Silva; Ontologia de dependência tecnológica de documentos digitais: Instrumento de Apoio à Preservação Digital, de EloiJunitiYamaoka e Fernando OstuniGauthier. Vale também destacar a nossa bela capa gentilmente elaborada pelo professor Adilson Luiz Pinto. Ótima leitura! Márcio Matias e Moisés Lima Dutra Editores – EdiçãoEspecial – 3º SBCC

  16. Editorial Editorial

    Directory of Open Access Journals (Sweden)

    Amálio Pinheiro

    2008-11-01

    Full Text Available

    O dossiê do presente volume, "Expressão visual e audiovisual nas mídias", apresenta três leituras sobre as relações de proximidade e diferença entre a criação de signos visuais e/ou audiovisuais e o mundo a que se referem.

    Marcius Freire discute, no documentário contemporâneo, as variações da alteridade das pessoas filmadas diante dos possíveis movimentos de câmera, próprios da história do gênero, das quais decorrem problemas éticos e estéticos. Ronaldo Entler desdobra uma espécie de classificação das possibilidades de representação do tempo na imagem fotográfica, dada a obviedade técnica do enquadramento espacial feito pelo corte.

    Regina Rossetti e João Batista Freitas Cardoso mostram, a partir das noções de "imagem" em Bergson e de "movimento" em Platão, como todo processo cinematográfico de produção e recepção audiovisual quer tornar estável a instabilidade móvel das coisas da chamada realidade. Os artigos estão aqui alinhados segundo sua proximidade temática.

    Ana Claudia de Oliveira e Fernando Resende tratam, respectivamente, da identidade e da diferença na produção jornalística, a primeira fazendo uso de uma "semiótica das situações", que evidencia a categoria do sensível na mídia impressa, o segundo considerando as modificações do discurso do jornal diante das novas tecnologias das ditas sociedades globalizadas.

    Fabrício Silveira, Lourdes Gabrielli, Tânia Hoff e Mayra Rodrigues Gomes examinam nexos distintos entre corpo, mídia e espaços urbanos: Fabrício discorre sobre as extensões tecnológicas do grafite; Lourdes e Tânia, sobre as imagens do corpo no esporte; e Mayra, sobre as linguagens censuradas no teatro.

    Seguem-se dois textos de aprofundamento teórico sobre autores espec

  17. On predicting future economic losses from tropical cyclones: Comparing damage functions for the Eastern USA

    Science.gov (United States)

    Geiger, Tobias; Levermann, Anders; Frieler, Katja

    2015-04-01

    for the Eastern USA until the year 2100. The projection is based on downscaling five different GCM model runs for the RCP8.5 scenario, as conducted by Emanuel et al. [7], and accounts for population and GDP changes relying on the newly developed Shared Socioenonomic Pathways (SSPs) [8]. We hereby contribute valuable input to the scientific community as well as the societies at risk. The possibility of extending this work to different regions in order to access the future impact of tropical cyclones on a global scale will also be discussed. References [1] Thomas R. Knutson, John L. McBride, Johnny Chan, Kerry Emanuel, Greg Holland, Chris Landsea, Isaac Held, James P. Kossin, A. K. Srivastava, and Masato Sugi. Tropical cyclones and climate change. Nature Geoscience, 3(3):157-163, 2010. [2] Robert Mendelsohn, Kerry Emanuel, Shun Chonabayashi, and Laura Bakkensen. The impact of climate change on global tropical cyclone damage. Nature Climate Change, 2(3):205-209, 2012. [3] Silvio Schmidt, Claudia Kemfert, and Peter Höppe. The impact of socio-economics and climate change on tropical cyclone losses in the USA. Regional Environmental Change, 10(1):13-26, 2009. [4] William D. Nordhaus. The Economics of Hurricanes and Implications of Global Warming. Climate Change Economics, 01(01):1-20, 2010. [5] Kerry Emanuel. Global Warming Effects on U.S. Hurricane Damage. Weather, Climate, and Society, 3(4):261-268, 2011. [6] Richard J. Murnane and James B. Elsner. Maximum wind speeds and US hurricane losses. Geophysical Research Letters, 39(16):707, 2012. [7] Kerry Emanuel. Downscaling CMIP5 climate models shows increased tropical cyclone activity over the 21st century. Proceedings of the National Academy of Sciences of the United States of America, 110(30):12219-24, 2013. [8] Detlef P. van Vuuren, Keywan Riahi, and Richard Moss. A proposal for a new scenario framework to support research and assessment in different climate research communities. Global Environmental Change, 22

  18. The impact of overlapping processes on rockfall hazard analysis - the Bolonia Bay study (southern Spain)

    Science.gov (United States)

    Fernandez-Steeger, T.; Grützner, C.; Reicherter, K.; Braun, A.; Höbig, N.

    2009-04-01

    from the described investigation show that on a screening and planning level the results of the empirical methods are quite good. Especially for numerical simulation, where back analysis is common to parameterize the models, the identification of "ideal" rockfalls is essential for a good simulation performance and subsequently for an appropriate planning of protection measures. References Corominas, J. 1996. The angle of reach as a mobility index for small and large landslides. Canadian Geotechnical Journal, 33, 260 - 271. Dorren, L.K. 2003. A review of rockfall mechanics and modeling approaches. Progress in Physical Geography, 27 (1), 69 - 87. Evans, S. & Hungr, O. 1993. The assessment of rockfall hazard at the base of talus slopes. Canadian Geotechnical Journal, 30, 620 - 636. Heim, A. 1932. Bergsturz und Menschenleben. Vjschr. d. Naturforsch Ges. Zürich, 216 pp. Silva P.G., Reicherter K., Grützner C., Bardají T., Lario J., Goy J.L., Zazo C., & Becker-Heidmann P. 2009. Surface and subsurface paleoseismic records at the ancient Roman city of Baelo Claudia and the Bolonia Bay area, Cádiz (South Spain). Geol Soc of London Spec. Vol.: Paleoseismology: Historical and prehistorical records of earthquake ground effects for seismic hazard assessment. In press. Spang, R. M. & Sonser, Th. 1995. Optimized rockfall protection by "ROCKFALL". Proc 8th Int Congress Rock Mechanics, 3, 1233-1242.

  19. Editorial

    Directory of Open Access Journals (Sweden)

    Revista Psicoperspectivas

    2008-12-01

    cercano pertenezca a las bases de datos de indexación de revistas académicas, sino que sea reconocida como un referente de publicación de investigaciones y reflexiones teóricas y metodológicas. Agradecemos al Director del Sistema de Biblioteca de la PUCV, Dr. Atilio Bustos González, por su valiosa asesoría.

    Los años de trabajo de los anteriores Editores de la Revista, Sr. Luis Bertoglia (Q.E.P.D. y Dr. Luis Ahumada, nos permiten plantearnos estos nuevos desafíos. En sus inicios, la revista PSICOPERSPECTIVAS fue creada y gestionada como plataforma para mostrar el trabajo de los docentes de la Escuela de Psicología de la Pontificia Universidad Católica de Valparaíso. Hoy, deseamos abrir las puertas y ofrecer un espacio de intercambio de ideas, de producciones y de colaboracio-nes mutuas y lejanas. Por ello, invitamos a la comunidad científica nacional e internacional a presentar sus trabajos en nuestra plataforma.

    El espíritu de lo que REVISTA PSICOPERSPECTIVAS busca está reflejado en esta edición. Los artículos de Luisa Castaldi, de Claudia Perlo, María del Rosario de la Riestra y Leticia Costa, así como el de Paula Ascorra Costa, nos ofrecen perspectivas particulares de posiciona-miento e intervención en temáticas relacionadas con los ámbitos de la Psicología Clínica y Organizacional. El artículo de Nicole Schmal y Pilar Camps es un informe de investigación en el ámbito de la psico-logía jurídica. Por su parte, los artículos de Raquel Ribeiro y de Vicen-te Sisto entregan reflexiones maduradas acerca de los retos de los paradigmas contemporáneos para la Psicología y las Ciencias Sociales en cuanto a la producción de conocimientos y sus consecuencias metodológicas.

    Invitamos, entonces, a los antiguos y futuros lectores a compartir con nosotros este desafío en que hoy nos embarcamos. Bienvenidos a la nueva edición de la REVISTA PSICOPERSPECTIVAS.

    Dra. Verónica López Leiva

  20. Homenaje al Profesor Académico Juan Di Doménico.

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    Roberto Vergara Támara

    2004-03-01


    Nápoles en 1924 donde completó su bachillerato Académico en el Liceo Umberto 1. Estudió medicina desde 1931 y se graduó en 1937. En 1938 aprobó los exámenes estatales para ejercer la medicina en Italia.

    Casado con Carmen Buraglia Stella (1947-1992. Sus hijos: Juan Francisco, Cirujano y Claudio Maurizio, Arquitecto, constructor. Sus nietos: Stefano, Eric, Claudia y Valeria.
    Viajó a Estados Unidos, se especializó en Cirugía General. Internado Rotatorio en el Merey Hospital Davenport, lowa, 1939-1940. Se matriculó en un Curso de Cirugía General en el Cook County Graduate School of Medicine, 1939-1941 Yen la Mayo Clinic de Rochester, Minnesota. Asistió además al Columbus Hospital de New York y al Charity Hospital de New Orleans...


  1. Editorial - Arquivologia 10.5007/1518-2924.2011v16nesp1pi

    Directory of Open Access Journals (Sweden)

    José Maria Jardim

    2011-06-01

    contribuíram com artigos para este número especial.Convidamos um conjunto de autores que, pela sua diversidade de interesses e inserção institucional, poderiam oferecer ao público interessado reflexões sobre alguns temas de interesse arquivístico. Ao lado de profissionais com carreira consolidada no campo, buscamos viabilizar a participação de arquivistas que estão em construção do seu percurso profissional, aventurando-se pela pós-graduação. A Profa. Angélica Marques, do Curso de Arquivologia da Universidade de Brasília (UnB, oferece-nos um rico estudo sobre temáticas arquivísticas na Ciência da Informação. Diretora do TEAM Brasil no Projeto de pesquisa internacional InterPARES 3, Claudia Lacombe, do Arquivo Nacional, apresenta-nos reflexões sobre a complexa tarefa de tradução do Glossário multilíngue do Projeto InterPARES 3. A Profa. Anna Carla Almeida Mariz, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO, convida-nos ao debate sobre parâmetros para análise de sites de instituições arquivísticas sob a perspectiva da transferência da informação no ambiente da internet e suas demandas ao arquivista. Claudio Muniz Viana, arquivista da Universidade Federal do Estado do Rio de Janeiro (UFRJ, aborda um tema de interesse crescente, os arquivos de arquitetura, a partir da experiência do Núcleo de Pesquisa e Documentação da Faculdade de Arquitetura e Urbanismo da UFRJ. Arquivista da FIOCRUZ, Rose Tenório de Oliveira, apresenta-nos várias correlações entre a inexistência de políticas arquivísticas e a preservação de acervos documentais. O uso da microfilmagem e da digitalização para a preservação e acesso de documentos arquivísticos num contexto de opções tecnológicas à disposição dos arquivistas é contemplado com profundidade pelo Prof. Sérgio Conde de Albite Silva, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO. As professoras Eliana Maria dos

  2. EDITORIAL - ARQUIVOLOGIA

    Directory of Open Access Journals (Sweden)

    José Maria Jardim

    2011-01-01

    artigos para este número especial. Convidamos um conjunto de autores que, pela sua diversidade de interesses e inserção institucional, poderiam oferecer ao público interessado reflexões sobre alguns temas de interesse arquivístico. Ao lado de profissionais com carreira consolidada no campo, buscamos viabilizar a participação de arquivistas que estão em construção do seu percurso profissional, aventurando-se pela pós-graduação.A Profa. Angélica Marques, do Curso de Arquivologia da Universidade de Brasília (UnB, oferece-nos um rico estudo sobre temáticas arquivísticas na Ciência da Informação. Diretora do TEAM Brasil no Projeto de pesquisa internacional InterPARES 3, Claudia Lacombe, do Arquivo Nacional, apresenta-nos reflexões sobre a complexa tarefa de tradução do Glossário multilíngue do Projeto InterPARES 3. A Profa. Anna Carla Almeida Mariz, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO, convida-nos ao debate sobre parâmetros para análise de sites de instituições arquivísticas sob a perspectiva da transferência da informação no ambiente da internet e suas demandas ao arquivista. Claudio Muniz Viana, arquivista da Universidade Federal do Estado do Rio de Janeiro (UFRJ, aborda um tema de interesse crescente, os arquivos de arquitetura, a partir da experiência do Núcleo de Pesquisa e Documentação da Faculdade de Arquitetura e Urbanismo da UFRJ. Arquivista da FIOCRUZ, Rose Tenório de Oliveira, apresenta-nos várias correlações entre a inexistência de políticas arquivísticas e a preservação de acervos documentais. O uso da microfilmagem e da digitalização para a preservação e acesso de documentos arquivísticos num contexto de opções tecnológicas à disposição dos arquivistas é contemplado com profundidade pelo Prof. Sérgio Conde de Albite Silva, do Curso de Arquivologia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO. As professoras Eliana Maria dos Santos Bahia e

  3. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-01-01

    geschiedenis van de Indisch-Nederlandse dagbladpers, 1744-1905. Amsterdam: Nijgh en Van Ditmar, Leiden: KITLV Uitgeverij, 2001, 862 pp. -Edwin Wieringa, Marijke J. Klokke, Narrative sculpture and literary traditions in South and Southeast Asia. Leiden: Brill, 2000, xiv + 127 pp. [Studies in Asian Art and Archaeology (continuation of: Studies in South Asian Culture 23.] -Catharina Williams-van Klinken, Mark Donohue, A grammar of Tukang Besi. Berlin: Mouton de Gruyter, 1999, xxvi + 576 pp. [Mouton Grammar Library 20.] -Kees Zandvliet, Thomas Suárez, Early mapping of Southeast Asia. Singapore: Periplus Editions, 1999, 280 pp. -Claudia Zingerli, Bernhard Dahm ,Vietnamese villages in transition; Background and consequences of reform policies in rural Vietnam. Passau: Department of Southeast Asian Studies, University of Passau, 1999, xiv + 224 pp. [Passau Contributions to Southeast Asian Studies 7.], Vincent J.H. Houben (eds

  4. Obituary: Hugo Schwarz, 1953-2006

    Science.gov (United States)

    Krisciunas, Kevin

    2007-12-01

    , p. 430, 2006). One of the projects well along at the time of his death was a collaboration with David Spergel and a number of REU summer students on the measurement of the polarization of 2,000 stars evenly distributed around this sky. This simple set of data being obtained with the NOT, a telescope Hugo helped make fully functional, will, by a factor of two, improve the sensitivity of experiments such as WMAP and Planck to the detection of gravity waves, one of the holy grails of experimental physics. Because of Hugo's sense of humor, enthusiasm, and perspective, he achieved a good balance between work and play. He could play the diplomat and hobnob with politicians and royalty. He also was proud of the fact that his native language, Dutch, is probably the best language for swearing. He often adopted a Glaswegian accent from his time at university, and would ask you a common question of bartenders there: "So, Jimmy, what's yer name?" He loved fine cigars, particularly the flojos (not-so-tightly rolled ones) from his cigar maker in La Palma, which he generously shared with friends. He loved having people over for barbecues, and would often make paella. Which newspaper was used to cover the large pan was important. It had to be left of center politically, but not too far left. On Hugo's fiftieth birthday a temporary addition was built onto the house, carpeting was laid out on the lawn, and there ensued a sit down dinner for 107 people, complete with live musicians, and many broken glasses. Hugo is survived by his wife Claudia Sanhueza, his two children Tamar and Jouke Schwarz, his step-children Maria Josefina and Diego Gomez, and his half-brother James Schwarz. More than anyone I can think of, he also leaves behind many friends who considered him their best friend.

  5. Missing links in the root-soil organic matter continuum

    Energy Technology Data Exchange (ETDEWEB)

    O' Brien, Sarah L. [Argonne National Laboratory (ANL); Iversen, Colleen M [ORNL

    2009-01-01

    }]. Rising atmospheric [CO{sub 2}] and other changing environmental factors add a layer of complexity to the quest to understand microbial process. For example, Claudia Boot demonstrated that microbially mediated C and N cycling in Mediterranean California grasslands is intricately linked with summer drought. Ongoing research across subdisciplines seeks to uncover the many complex links between soil organisms of all sizes and the root-SOM continuum. While the role that living organisms play in the transformation of root detritus to SOM is disproportionate to their body size, the nonliving soil environment also influences SOM cycling. However, destructive sampling can obscure feedbacks between abiotic and biotic processes, making it difficult to quantify the role of edaphic factors in the root-SOM continuum.

  6. Editorial: Theoriebildung in Mediendidaktik und Wissensmanagement

    Directory of Open Access Journals (Sweden)

    Michael Kerres

    2002-10-01

    Full Text Available Das Internet trägt massgeblich zur Entstehung einer neuen Lern- und Wissenskultur bei und ist mittlerweile Gegenstand einer ganzen Reihe von Projekten in der Erziehungswissenschaft. So wird zum Beispiel der Frage nachgegangen, welche Möglichkeiten der Strukturierung und Gestaltung von Lernmaterialien am besten geeignet sind, um Lernprozesse anzuregen, wie die interpersonale Kommunikation im Internet durch didaktische Gestaltungsmassnahmen gefördert werden können oder wie die entfernte Betreuung von Lernenden über das Netz funktioniert. Zunehmend wird dabei auch der Übergang bedeutsam zwischen didaktisch aufbereiteten Lernangeboten, wie sie die Mediendidaktik traditionell beschäftigt, und dem Austausch von nicht didaktisch aufbereiteten Informationen in Organisationen, wie es im Bereich des Wissensmanagements diskutiert wird. In diesen Projekten werden vielfach Detailfragen behandelt, und isoliert, ohne Bezug zu grundlegenden Theoriefragen untersucht. Es mangelt an einer genuin mediendidaktischen Theoriediskussion, die einen übergreifenden Bezugsrahmen aus erziehungswissenschaftlicher Perspektive liefert. In der Vergangenheit ist die Mediendidaktik von Seiten einer «kritischen» Medienpädagogik zeitweise skeptisch beäugt und in ihrer Existenz grundlegend infrage gestellt worden. In der aktuellen Diskussion wird gerne auf lerntheoretische Ansätze zurückgegriffen, die Lernen als aktiven Vorgang der individuellen und kooperativen Wissenskonstruktion begreifen. Doch Wissens- und Lerntheorien ersetzen keine mediendidaktische Modell- und Theoriebildung, die Perspektiven für eine Gestaltung zukünftiger Lernwelten liefert und dabei zum Beispiel sowohl bildungstheoretische Überlegungen als auch Konzepte des instructional design einbezieht. In dem ersten Teil dieser Ausgabe geht es um theoretische Perspektiven der Mediendidaktik. So diskutiert der Artikel von Michael Kerres und Claudia de Witt den Beitrag der Positionen von Behaviorismus

  7. PREFACE: XIV International Conference on Calorimetry in High Energy Physics

    Science.gov (United States)

    Wang, Yifang

    2011-03-01

    (Texas Tech University), Weidong Li (IHEP) 3) Readout techniques - Gerald Eigen (University of Bergen), Zheng Wang (IHEP) 4) Operating calorimeters and calibration - Marat Gataullin (CERN), Francesco Lanni (BNL) 5) Future calorimetry - Tohru Takeshita (Shinshu University), Lei Xia (Argonne National Laboratory) 6) Astrophysics and neutrino calorimetry - Giuliana Fiorillo (INFN), Hiro Tajima (SLAC) List of Participants AKCHURIN, NuralTexas Tech University AN, ZhenghuaIHEP AUFFRAY, EtiennetteCERN BANFI, DaniloUniversità degli Studi di Milano, INFN BASHARINA-FRESHVILLE, AnastasiaUniversity College London BEAUCHEMIN, Pierre-HuguesUniversity of Oxford BENAGLIA, Andrea DavideUniversity of Milano - Bicocca and INFN BIAN, JianminIHEP BIINO, CristinaINFN BILKI, BurakUniversity of Iowa BLAHA, JanLAPP BOUDRY, VincentLLR / CNRS-IN2P3 CAI, XiaoIHEP CAPONE, AntonioPhysics Department University "La Sapienza" and INFN CAVALLARI, FrancescaCERN and INFN Rome CECCHI, ClaudiaUniversity di Perugia e INFN CHANG, JinfanIHEP CHEN, HuchengBrookhaven National Laboratory CHILDERS, TaylorUniversität Heidelberg - Kirchhoff-Institut für Physik DAO, ValerioGeneva University - DPNC DE LA TAILLE, ChristopheIN2P3/OMEGA-LAL DIEMOZ, MarcellaINFN Roma DOTTI, AndreaCERN EIGEN, GeraldUniversity of Bergen EPIFANOV, DenisBudker Institute of Nuclear Physics FAIVRE, JulienLPSC Grenoble France FANG, JianIHEP FANG, ShuangshiIHEP FANTONI, AlessandraINFN - LNF FERRI, FedericoCEA/Saclay Irfu/SPP FERRONI, FernandoSapienza University & INFN Roma FISK, Henry EugeneFermilab GABALDON, CarolinaCERN GARUTTI, ErikaDESY GAUDIO, GabriellaIstituto Nazionale di Fisica Nucleare - Sezione di Pavia GILLBERG, DagCarleton University GIOVANNINI, PaolaMax-Planck-Institut für Physik GLAZOV, AlexanderDESY GRACHOV, OlegUniversity of Kansas HAPPACHER, FabioINFN HE, MiaoIHEP HORI, YasutoUniversity of Tokyo, CNS HU, TaoIHEP HULTH, Per-OlofStockholm University JUN, Soon YungCarnegie Mellon University JURK, StefanISEG Spezialelektronik gmb

  8. Clínica de Marly 90 Años de su Fundación

    Directory of Open Access Journals (Sweden)

    Jorge Cavelier Gaviria

    1994-12-01

    . Nacido en el ilustre hogar de Don Nicolás Esguerra Ortiz “El ciudadano perfecto de una era de hombres eximios” al decir del profesor Luis López de Mesa, pertenece así a la llamada generación del 70 que dio brillo sin par a nuestra patria con hombres de la altura de Manuel Murillo Toro, Santiago Pérez, Aquilea Parra, Francisco Javier Zaldúa, Eustorgio Salgar, Salvador Camacho Roldán, Rafael Núñez, Miguel Antonio Caro.

    En 1884, a los 21 años, Carlos Esguerra se gradúa de médico y cirujano para comenzar en el indómito valle del Río Magdalena su ejercicio profesional y continuar estudios de la fiebre amarilla ya iniciados por su tío el Dr. Domingo Esguerra. Pero pronto, a causa de razones políticas abandona el país en unión de su padre con destino a Caracas, donde se recibió de médico de la Universidad Central.

    Luego, cuando los dos viajeros optaron por trasladarse a París, llega a la mitad del tan fecundo decenio de 1880 a 1890, época gloriosa de la medicina francesa. Repasa allí su currículum y observa cómo la medicina hipocrática, llena de imaginación, se despedía para siempre al dar paso a la nueva etapa técnica desarrollada gracias a Luis Pasteur, Roberto Koch, Rodolfo Wirchow, Gregario Mendel, Segismundo Freud, Santiago Ramón y Cajal y Claudia Bernard. Tal vez allí, ideó establecer una casa de salud para pacientes pensionados, cercana a Bogotá y similar a las que funcionaban en las grandes naciones europeas y en los Estados Unidos.

    Por todos los aspectos, la casaquinta Marly, era el sitio ideal para establecer la casa de salud y en esto estuvieron de acuerdo los hermanos Guillermo y Carlos Esguerra, quienes confiaron en el éxito del proyecto.

    Hasta ese momento los enfermos capitalinos eran tratados e intervenidos quirúrgicamente bajo el denominador común de la caridad pública en el vetusto hospital de San Juan de Dios, el cual ocupaba un deteriorado caserón colonial, carente de las indispensables

  9. Editorial

    Directory of Open Access Journals (Sweden)

    Adilson Luiz Pinto

    2012-01-01

    agentes maliciosos, com vista a avaliar do uso do sistema em cenários simulados, verificando o potencial de ferramentas e funcionamento autonômico nestas atividades.Na seção de Dissertações e Teses, este número volta a resgatar os esforços dos nossos discentes e de seus respectivos orientadores, que por anos vem recorrendo um caminho promissor, em especial de suas premiações em âmbito nacional, como o estudo de Ana Claudia Perpétuo de Oliveira da Silva, sob a orientação do Professor Dr. Francisco das Chagas de Souza na última edição do ENANCIB/2012.Boa leitura!Adilson Luiz Pinto

  10. Sumário/Editorial

    Directory of Open Access Journals (Sweden)

    Comissão Editorial

    2008-11-01

    Full Text Available A revista Galáxia surgiu no cenário intelectual nacional para atestar que a vitalidade das múltiplas confluências entre Comunicação e Semiótica delimitava um campo de conhecimento maduro capaz de produzir a sua própria revista cientí­fica. Fiel ao seu nome - homenagem a Haroldo de Campos, que, em poema homônimo, sinalizava para o conví­vio entre fronteiras -, a revista assumiu sua vocação transdisciplinar. O Programa de Estudos Pós-Graduados em Comunicação e Semiótica da PUC/SP confiou o projeto inicial do periódico a Irene Machado, que respondeu, de forma notável, pela editoria cientí­fica dos sete primeiros números. A dedicação de Irene Machado contribuiu para consolidar a proposta dos trânsitos e fluxos de idéias como fatores de fomento da diversidade que marca a Comunicação como campo cientí­fico. Sem esse competente trabalho, a revista não teria alcançado o significativo patamar Nacional A na escala de avaliação do sistema Qualis/CAPES. Nessa esteira, feita em nome do Programa, os rigores de edição do presente volume ficaram a cargo de uma comissão composta por Lucrécia D'Aléssio Ferrara, Ana Claudia de Oliveira, Eugênio Trivinho e Helena Katz. Galáxia 8 apresenta uma dupla articulação na seção "Fórum". José Luiz Fiorin mostra as contribuições de uma teoria da significação para a compreensão dos fenômenos comunicacionais, que não se restringem ao âmbito da produção de massa. Eric Landowski, por sua vez, chama a atenção para um outro regime de interpretação das encenações do corpo numa detalhada análise ancorada em quatro dimensões especí­ficas do retrato (mimética, hermenêutica, cosmética e estética, na qual a fotografia dos homens polí­ticos na imprensa é tratada como componente de uma estratégia discursiva midiática global. A problematização dessas dimensões possibilita ao autor desenvolver uma teoria semiótica da visualidade midiática. Com essas duas

  11. 7th Young Researcher Meeting

    International Nuclear Information System (INIS)

    2017-01-01

    in an online/offline shared area and exploit the best of both sides” adding a bottom-up approach where “young researchers can now submit their own ideas and research/application projects directly to possible interested companies” . It is mainly based on the Elevator Pitch paradigm, complementary to the traditional top-down approach where companies advertise their openings/research challenges and the interested candidates submit their proposals. This volume consists in a selection of the contributions presented at the conference as either talks or posters. These cover topics in astrophysics and cosmology, particle and theoretical physics, soft and condensed matter, medical physics, quantum information and quantum technologies, and of course metrology. Organising and Editorial Committee Fabio Agostini (fabioagostini31@gmail.com) NAIS Alessio Avella (a.avella@inrim.it) INRiM Rugiada Cuccaro (r.cuccaro@inrim.it) INRiM Marco Di Stefano (marco.distefano@cnag.crg.eu) Centre Nacional d’Anàlisi Genòmica - Centre de Regulació Genòmica (CNAG-CRG) Lapo Lolli (l.lolli@inrim.it) INRiM Lorenzo Pagnanini (lorenzo.pagnanini@gssi.infn.it) Gran Sasso Science Institute Fabrizio Piacentini (f.piacentini@inrim.it) INRiM Emanuela Pusceddu (emanuela.pusceddu@gmail.com) National Research Council-CNR Matteo Serra (matteoserra83@gmail.com) Claudia Antolini (cla.antolini@gmail.com) Giordano Cattani (giordano.cattani@gmail.com) Alessandro Cultrera (a.cultrera@inrim.it) INRiM Giacomo Fragione (giacomo.fragione90@gmail.com) Hebrew University of Jerusalem Marina Migliaccio (migliaccio@asdc.asi.it) ASDC – ASI Science Data Center Enrica Pessana (e.pessana@inrim.it) INRiM Davide Pietrobon (daddeptr@gmail.com) Raffaella Romeo (r.romeo@inrim.it) INRiM Enrico Simonetto (e.simonetto@inrim.it) INRiM Francesco Stellato (francesco.stellato@roma2.infn.it) INFN Roma Tor Vergata Silvia Cavallero (Local Organising Committee) (s.cavallero@inrim.it) INRiM Acknowledgements The organisers of the 7 th

  12. Certain Verbs Are Syntactically Explicit Quantifiers

    Directory of Open Access Journals (Sweden)

    Anna Szabolcsi

    2010-12-01

    .Stechow, A. von. 2009. ‘Syntax and semantics: an overview’. To appear in: Maienborn, Claudia et al. (eds., Semantics: An International Handbook of Natural Language Meaning. Berlin: Mouton de Gruyter.Steedman, M. 1988. ‘Combinators and Grammars’. In R. Oehrle, E. Bach & D. Wheeler (eds. ‘Categorical Grammars and Natural Language Structures’, 417–442. Dordrecht.Steedman, M. 2000. The Syntactic Process. Cambridge, MA: The MIT Press.Stowell, T. 1995a. ‘The Phrase Structure of Tense’. In J. Rooryck & L. Zaring (eds. ‘Phrase Structure and Lexicon’, 277–291. Dordrecht: Kluwer.Stowell, T. 1995b. ‘What Do the Present and Past Tenses Mean?’ In P. Bertinetto et. al. (ed. ‘Temporal Reference, Aspect, and Actionality. Vol. 1: Semantics and Syntactic Perspectives’, 381–396. Torino: Rosenberg and Sellier.Szabó, Z. G. 2011. ‘Bare quantifiers’. Philosophical Review 120: 247–283.Szabolcsi, A. 1987. ‘Bound variables in syntax (are there any?’. In J. Groenendijk et. al. (ed. ‘Sixth Amsterdam Colloquium’, 331–351. Amsterdam: Institute for Language,Logic, and Information.Szabolcsi, A. 1992. ‘Combinatory grammar and projection from the lexicon’. In I. A. Sag & A. Szabolcsi (eds. ‘Lexical Matters. CSLI Lecture Notes 24’, 241–269. Stanford, CSLI Publications.Szabolcsi, A. 2009a. ‘Overt nominative subjects in infinitival complements cross-linguistically’.http://www.nyu.edu/gsas/dept/lingu/nyuwpl/.Szabolcsi, A. 2009b. ‘Overt nominative subjects in infinitival complements in Hungarian’. In M. den Dikken & V. Robert (eds. ‘Approaches to Hungarian 11’, 251–276. Amsterdam: John Benjamins.Szabolcsi, A. 2010. Quantification. Cambridge: Cambridge University Press.Yanovich, I. 2009b. ‘How Much Expressive Power Is Needed For Natural Language Temporal Indexicality?’ In L. D. Beklemishev & R. de Quieroz (eds. ‘Proceedings of Logic,Language, Information and Computation’, 293–309. 18th International Workshop, WoLLIC 2011

  13. Editorial

    Directory of Open Access Journals (Sweden)

    Gildenir Carolino Santos

    2012-12-01

    , RS, brings attention to a conceptual overview that emphasizes the importance of knowing the school reality as an element for school reorganization. Also, points out the use of institutional assessment as a subsidy for this reflexivity and for rearticulating actions. It situates public policies in different contexts, highlighting the practice as a locus of bureaucratic insubordination, in which counter regulation processes emerge, while the efforts of different actors of educational setting are articulated.A contribution from Mercosur, the third article, by Ana Maria Fernández Caraballo (Faculty of Psychology UdelaR, with the title "The academic tutorial in higher education: the case of UdelaR" deals with the ‘tutorial’ as it is classically used in university contexts - which is different from other tutorials of a pedagogical nature. This "academic tutorial" results from the knowledge production, unique effect of wisdom and ties between the tutor and the pupil. The focus is the tutoring at the University of the Republic (UdelaR.The following article, "Special education: distance pedagogical practices in teacher’s formation for Specialized Education Services (SES", where Ana Claudia Pavão Siluk and Sílvia Maria de Oliveira Pavão, both from the Federal University of Santa Maria, analyze the dimensions of teaching methodology, evaluative criteria and the theoretical assumptions from which a Course of Specialized Educational Services-SES, is structured."Printed Instructional materials for distance education: interfaces with the language practices", the fifth article, written by Michele Rodrigues de Albuquerque and Ivanda Maria Martins Silva, teachers of Federal Rural University of Pernambuco, analyzes the production of printed educational material for distance education (EAD - understanding distance education as a model in which students and teachers are physically separated, but joined together virtually through technological and pedagogical resources. It also

  14. 5th National Congress of the Italian Society of Physiotherapy

    Directory of Open Access Journals (Sweden)

    Alessandro Aina

    2016-10-01

    controlled pilot trial of hand robotic training compared with a sensory-motor training program in post stroke patients Violini Claudia, Cenci Marco Joseph, Delconte Carmen, Pisano Fabrizio P48 Critical Illness PolyNeuroMyopathy (CIPNM: chance for a good prognosis Youssef S, Montesano M, Picardi M, De Giampaulis P, Corbo M, Pisani L. P49 The EdUReP approach plus manual therapy for the management of insertional Achilles tendinopathy: a case study Zanetta Anna, Garzonio Fabiola, Ruella Carolina, Sartorio Francesco

  15. EDITORIAL: Student undergraduate laboratory and project work

    Science.gov (United States)

    Schumacher, Dieter

    2007-05-01

    will be the typical learning environment for physics students in the future. However, the details of this change should be based on a better understanding of the learning process in a students' lab. A deeper insight is given by the contribution of Claudia von Aufschnaiter and Stefan von Aufschnaiter in 'University students' activities, thinking and learning during laboratory work'. A second important alteration has taken place in physics education during the last decade. The so-called new media have changed the world of learning and teaching to an unprecedented extent. Learning with new media is often much more related to physics labwork than to traditional lectures or seminars (e.g. small learning groups, problem based learning, a high level of interactivity). We need to take these new tools into consideration as suitable amendment (blended learning) or substitution (e-learning, distance learning) of labwork courses. The developments with presumably the highest impact on physics education are modelling tools, interactive screen experiments and remote labs. Under 'modelling tools', all computer programs are summarized which enable the simulation of a physical process based on an explicit or implicit given formula. Many commercial program packages are available. The application of modelling tools in labwork courses permits a tight binding of theory and experiment. This is particularly valid and necessary in the case of project work. An interactive screen experiment (ISE) is a computer assisted representation of a physical experiment. When watching a video clip of an experiment students are forced to be passive observers. In the case of an ISE they can manipulate the setup on the screen with the help of a hand-like mouse pointer and the computer will show the appropriate result. The ISE consists of a large number of digital photos taken from the real experiment. From an epistemological point of view an ISE has the character of an experiment and can be used to discover or

  16. Digital Storytelling – Special issue

    Directory of Open Access Journals (Sweden)

    Yngve Nordkvelle

    2010-11-01

    Full Text Available Since the inception of Seminar.net the phenomenon of Digital Storytelling has often been suggested as a promising genre for teaching and learning in a variety of areas. Academically, the genre has attracted interest from scholars in media studies, political science, social work, health and education. In this issue we have sought attention from a huge number of academically inclined persons who either use the genre to teach with media, for teaching and learning about media, or studying how this specific way of working with media offers new possibilities for the articulation of the voice of the common people.When we invited authors for this special issue we did so expecting – and hoping for – contributions from a wide field of interests. We have landed 11 different manuscripts and have organised them according to a tentative order of themes they address: “Teaching and learning with Digital Storytelling”, “Community building”, “Genres of communication” and “Practical papers”.  Being a journal for lifelong learning, the educational use has gained the most interest. But also emerging new areas of use related to health, leisure, recreation, activism, community building, planning, professional communication, and reflection are reflected in the papers. We think the contributions together support our efforts for building the knowledge about digital storytelling as a genre and its potential in the media society. Scholarly publications in this field are generally mediated on paper. And there has been no shortage of superb exemplars of scholarly work these last couple of years: Story Circle: Digital Storytelling around the World, edited by John Hartley and Kelly McWilliams and Digital Storytelling, Mediatized Stories: Self-representations in New Media, edited by Knut Lundby, as well as a conference report, “Storytelling – Reflections in the Age of Digitalization” edited by Yvonne Gächter, Heike Ortner, Claudia Scwartz, Andreas

  17. Resumos dos Trabalhos Apresentados em Painéis no Workshop Baía de Guanabara, IGEO/UFRJ - 2002

    Directory of Open Access Journals (Sweden)

    2003-01-01

    matéria orgânica, estando a mesma, intercalada por lentes de areia, sobre um solo residual sobreposto ao embasamento cristalino. Conclui-se então, que os solos estudados, constitui-se de uma argila orgânica que apresenta um alto poder de sorção, o que viabiliza o processo de remediação natural. Agradecimentos: Petroflex Ind. & Com. S.A. Registros Palinológicos em Depósitos Quaternários da Praia Vermelha, Urca-RJ Robson Lucas Bartholomeu, Dept. Geologia UFRJ Ortrud Monika Barth, FIOCRUZ Marcia Aguiar de Barros, Dept. Geologia UFRJ Claudia Gutteres Vilela, Dept. Geologia UFRJ Laboratório de Palinologia, Departamento de Geologia, IGEO/UFRJ. Prédio CCMN, Bloco J, Sala J2-019, Cidade Universitária, Ilha do Fundão, CEP 21.949-900. Rio de Janeiro, RJ. E-mail: rlucasbr@yahoo.com.br O presente trabalho tem como objetivo conhecer a evolução da vegetação e do meio ambiente na Praia Vermelha, Urca, Rio de Janeiro, evidenciando as modificações na paisagem através da identificação de tipos polínicos caracterizadores de formações vegetais e ambientes. 144 Anuário do Instituto de Geociências - UFRJ Volume 26 / 2003 Foram selecionados sedimentos provenientes de um perfil estratigráfico obtido através de uma trincheira aberta no pós-praia, em trecho da Praia Vermelha, Urca, RJ, datados na base em 4520 +/- 80 anos antes do presente (A.P. Os sedimentos foram coletados com o auxílio de canaletas, com 45 cm de comprimento, 2,5 cm de largura e 2 cm de profundidade e blocos indeformados, utilizados nas análises sedimentológicas. Os resultados das análises palinológicas indicam na base do depósito o domínio da vegetação de Mata Atlântica, que gradualmente foi substituída por uma vegetação mais aberta, de campo. Os níveis da turfa inferior apresentam o predomínio dos tipos polínicos Schinus e Alchornea, característicos de Mata Atlântica e/ou de várzeas úmidas de formações secundárias. Os níveis da areia lamosa apresentam o domínio de

  18. Editorial: Computerspiele und Videogames in formellen und informellen Bildungskontexten

    Directory of Open Access Journals (Sweden)

    Johannes Fromme

    2008-01-01

    zu erproben, wie Computerspiele in den Bereich der aktiven, projektorientierten Medienarbeit eingebunden werden können, die sich dieser neuen Medien – im Unterschied zu Radio, Presse oder Film – bisher kaum angenommen hat. Das Konzept des Video Game Essays knüpft an der Film- und Videoarbeit an, erweitert es aber um einige neue Elemente, die mit den technischen Besonderheiten der Spiele zu tun haben. Der Ansatz kann als innovative Form der Medienanalyse angesehen werden, bleibt aber bei der Analyse nicht stehen, sondern eröffnet auch weitergehende Handlungs- und Lernpotenziale. Als Einsatzgebiete des Video Game Essays werden die ausserschulische Medienarbeit, die Schul- und die Hochschulausbildung genauer betrachtet. Claudia Lampert, Christiane Schwinge und Daniel Tolks zeichnen in ihrem Beitrag die bisherigen Entwicklungen im Bereich der Serious Games nach, die von anderen Ansätzen des mediengestützten Lernens wie E-Learning, Edutainment und Game-Based Learning abgegrenzt werden, und arbeiten den aktuellen Diskussions- und Forschungsstand auf. Die Potenziale und Grenzen werden am Beispiel zweier Spiele aus dem Gesundheitsbereich (Games for Health detaillierter diskutiert, für die auch erste empirische Befunde vorliegen. Serious Games gewinnen zwar – nach Ansicht der Autoren/innen vor allem aus Marketinggründen – zunehmend an Bedeutung, allerdings bestehe noch ein erheblicher Forschungs- und Evaluationsbedarf. Sabrina Schrammel und Konstantin Mitgutsch kritisieren, dass im medienpädagogischen Diskurs über Computerspiele der Umstand vernachlässigt werde, dass Spielen eine kulturell geprägte, aktive Auseinandersetzung mit einem Spielgegenstand sei. Ihnen geht es im vorliegenden Beitrag daher darum, die spezifische medial- kulturelle Praktik des Computerspielens zu erfassen bzw. dafür einen geeigneten methodischen und theoretischen Zugang zu entwickeln und vorzustellen. Das Spielen von Computerspielen wird in Anlehnung an den internationalen Diskurs

  19. El proyecto “Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease” (CHICAMOCHA: 15 años construyendo un activo institucional de la Universidad Autónoma de Bucaramanga-UNAB / Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas Disease Project. CHICAMOCHA: 15 Years Building an Asset for The Universidad Autónoma de Bucaramanga-UNAB / O Projeto Cardiovascular Investigação de Saúde e colaboração para avaliar os marcadores e resultados da doença de Chagas CHICAMOCHA: 15 anos construindo um ativo institucional na Universidade Autônoma de Bucaramanga-UNAB

    Directory of Open Access Journals (Sweden)

    Juan Carlos Villar-Centeno, MD., Esp., MSc., PhD

    2015-07-01

    Full Text Available El 3 de mayo del año 2000 asistió a una oficina de la entonces naciente Facultad de Medicina de la Universidad Autónoma de Bucaramanga (UNAB, quien fuera el primer participante de un proyecto llamado “Cardiovascular Health Investigation and Collaboration to Assess the Markers and Outcomes of Chagas disease” (CHICAMOCHA. Su estudio piloto, planeado para un año, fue financiado por el departamento de ayudas a la comunidad de ECOPETROL (a través de un convenio con el ISABU, firmado por el entonces director, el actual decano de la facultad, Dr. Juan José Rey. El apoyo dado por el director de investigaciones de la UNAB, Dr. Germán Oliveros, y el decano en la época, Dr. Juan Carlos Mantilla encontró un rector dispuesto, el Dr. Gabriel Burgos Mantilla, que equiparó el apoyo económico con el del patrocinador externo. Con ese soporte, bajo la coordinación del Dr. Luis Ángel Villar, el equipo de trabajo inicial (Víctor Mauricio Herrera, médico, Martha Vásquez, enfermera y Claudia Ríos, secretaria inició este proyecto. CHICAMOCHA fue concebido para que – estudiando donantes de sangre con pruebas de tamización positivas o negativas para Trypanosoma cruzi en una relación 1:4 – se sirvieran dos propósitos: El primero era facilitar el estudio del diagnóstico temprano de la cardiomiopatía de Chagas, por comparación con su contraparte de seronegativos; el segundo, a mayor plazo, era construir una cohorte de adultos jóvenes clínicamente sanos. Esto permitiría, luego de varios años de observación, contribuir al estudio de la enfermedad cardiovascular de origen aterosclerótico y sus factores de riesgo, como aporte al conocimiento de las enfermedades crónicas no transmisibles (ECNT en nuestro medio. En esta editorial haremos énfasis en la segunda meta, cumplida más de una década después. Luego de varios intentos por superar las dificultades logísticas, se logra conseguir financiación de Colciencias para reevaluar los

  20. Editorial 32

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    Nylza Offir García Vera

    2011-12-01

    ón educativa para personas con discapacidad desde una posición que vincula tales procesos a las condiciones de posibilidad para una vida digna y con justicia social.De otra parte, las investigaciones acerca de los procesosde inclusión de estudiantes sordos a una institución educativa ofrecen también un panorama diverso de las condiciones no sólo físicas y materiales sino también pedagógicas, didácticas, disciplinares y contextuales que requiere esta educación inclusiva. Así lo reconocen tanto Pablo Salazar, Rita Flórez y Clemencia Cuervo ?a partir de las estructuras y prácticas organizacionales escolares que nos presentan? como el grupo Conocimiento profesionaldel profesor de Ciencias, que analiza estas mismas condiciones de inclusión en la educación superior, de manera específica en la Licenciatura en Biología de la Universidad Pedagógica Nacional.Desde la línea de las mediaciones e incorporación de las TIC en educación, dos reflexiones interpelan los ámbitos pedagógico y político de la educación virtual en nuestro país: la dimensión pedagógica como una reflexiónpendiente –tesis de Claudia Rozo– y la pregunta por las políticas que subyacen a este tipo de educación, aunada a la esfera política del ser humano –planteamientocentral del artículo de Diana Sáenz–. Por su parte, Myriam Leguízamo y Omar López examinan la relación existente entre el logro académico obtenido, por estudiantes de secundaria, en la interacción con un ambiente hipermedia sobre operadores tecnológicos y la formulación de metas de aprendizaje auto-impuestas y metas de aprendizaje asignadas.Conforman también este número un avance de la investigaciónen torno a la didáctica de la imagen ofrecida por Rafael Barragán y Wilson Gómez y una investigación culminada acerca del éxito en la Enseñanza de las CienciasBasada en Indagación (ECBI, un modelo aplicado en el marco del Programa Pequeños Científicos en la ciudad de Ibagué; el grupo de investigaci

  1. only: A Case Study In Projective Meaning

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    Craige Roberts

    2010-12-01

    and Semantics, Vol. 11, Academic Press, NY.Kratzer, A. 1980. ‘The notional category of modality’. In H. J. Eikmeyer & H. Reiser (eds. ‘Words, Worlds and Contexts’, 38–74. de Gruyter, Berlin.Kratzer, A. 1989. ‘An investigation of the lumps of thought’. Linguistics and Philosophy 12, no. 5: 607–653.http://dx.doi.org/10.1007/BF00627775Lewis, D. 1969. Convention: A philosophical study. Harvard University Press.Lewis, D. 1973. Counterfactuals. Blackwell Publishers, Oxford.McCawley, J. D. 1981. Everything that Linguists Have Always Wanted to Know about Logic But Were Ashamed to Ask. University of Chicago Press.Partee, B. H. 1996. ‘Allegation and Local Accommodation’. In B. H. Partee & P. Sgall (eds. ‘Discourse and Meaning: Papers in Honor of Eva Hajicová’, 38–74. John Benjamins, Amsterdam.Potts, C. 2005. The Logic of Conventional Implicatures. Oxford University Press.Potts, C. to appear. ‘Conventional implicature’. In Claudia Maienborn, Klaus von Heusinger & Paul Portner (eds., Semantics: An international handbook of natural language meaning. Berlin, New York: Mouton de Gruyter.Roberts, C. 1987. Modal Subordination, Anaphora, and Distributivity. Ph.D. thesis, University of Massachusetts at Amherst.Roberts, C. 1989. ‘Modal Subordination and Pronominal Anaphora in Discourse’. Linguistics and Philosophy 12: 683–721.http://dx.doi.org/10.1007/BF00632602Roberts, C. 1996a. ‘Information Structure: Towards an integrated theory of formal pragmatics’. In H. Yoon & A. Kathol (eds. ‘OSU Working Papers in Linguistics 48’, 91–136. The Ohio State University. To appear with a new Afterword in Semantics and Pragmatics.Roberts, C. 1996b. ‘Anaphora in intensional contexts’. In Shalom Lappin (ed. ‘Handbook of Semantics’, 215–246. Blackwell.Roberts, C. 2004. ‘Discourse context in dynamic interpretation’. In Laurence Horn & Gregory Ward (eds. ‘Handbook of Contemporary Pragmatic Theory’, 197–220. Blackwell.Roberts, C. 2006.

  2. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference

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    Cristian-Mihail Niculae

    2016-11-01

    ța in the period 01 January 2014–30 June 2016. Epidemiological considerations. Iulia Gabriela Șerban, Ghiulendan Resul, Consuela Marcaș A47 Acute liver failure with favorable evolution in an HIV-HBV coinfected patient Iosif Marincu, Patricia Poptelecan, Bogdan Trincă, Sorina Mitrescu, Anca Tudor, Daliborca Vlad, Livius Tirnea A48 Lifestyle impact on HIV management Nurcan Baydaroglu, Alina Cristina Neguț, Oana Săndulescu, Daniela Manolache, Gabriela Ceapraga, Monica Andreea Stoica, Anca Streinu-Cercel, Adrian Streinu-Cercel 49. HIV positive mothers newborns - clinical experience from January 2012 to June 2016 Carmen Manciuc, Mariana Pagute, Cristina Nicolau, Carmen Dorobăț, Alexandra Largu A50 Rediscovering HIV-associated progressive multifocal leukoencephalopathy and HIV encephalopathy: clinical suspicion and subsequent brain autopsies Ioan-Alexandru Diaconu, Laurențiu Stratan, Daniela Ion, Luciana Nichita, Cristina Popescu, Raluca Năstase, Daniela Munteanu, Violeta Molagic, Cătălin Tilișcan, Mihaela Rădulescu, Alexandra Diaconu, Anca Negru, Alina Orfanu, Cristina Dragomirescu, Remulus Catană, Anca Leuștean, Irina Duport-Dodot, Cristina Murariu, Iulia Bodoșca, Violeta Niță, Alexandra Badea, Victoria Aramă A51 Antenatal surveillance of pregnant women with risk behavior and its impact on mother-to-child HIV transmission in Romania Mariana Mărdărescu, Cristina Petre, Marieta Iancu, Rodica Ungurianu, Alina Cibea, Ruxandra Drăghicenoiu, Ana Maria Tudor, Delia Vlad, Sorin Petrea, Carina Matei, Dan Oțelea, Carmen Crăciun, Cristian Anghelina, Alexandra Mărdărescu A52 Noninvasive assessments (APRI, Fib-4, transient elastography of fibrosis in patients with HIV and HIV/HBV infection Elena Dumea, Adrian Streinu-Cercel, Sorin Rugină, Lucian Cristian Petcu, Stela Halichidis, Simona Claudia Cambrea A53 Undetectable HIV viral load – the main goal in the management of HIV-infected patients Carmen Chiriac, Nina-Ioana Bodnar, Iringo-Erzsebet Zaharia

  3. Programa de Pós-Graduação em Geologia - Teses Defendidas 1998 - Doutorado - Instituto de Geociências - Universidade Federal do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    1998-01-01

    distância, no Morro da Fome. No estado do Rio de Janeiro, temos o sítio arqueológico de Itaboraí, no município do mesmo nome. O sítio está inserido em uma rampa de colúvio situada nos bordos da Bacia Calcária de São José de Itaboraí. 123 Anuário do Instituto de Geociências - UFRJ Volume 21 / 1998 A partir da década de 70 foram utilizados os métodos da relação silte-argila, ferro (Fe livre - ferro (Fe cristalizado, estratigráfico, tipológico e o da correlação geomorfológica (manchas climáticas. O método tipológico revelou uma cadeia tecnológica na confecção dos artefatos cobrindo as técnicas usadas em outras partes do mundo, indo do Pleistoceno Inferior ao Superior, reforçando os resultados obtidos pelos outros métodos relativos. O método absoluto do C14 foi usado à superfície do sítio. Apresentaram-se, também, as vantagens do estudo das manchas climáticas sobre os artefatos para avaliação cronológica. Finalmente, procurou-se através da apresentação dos três casos acima expostos, evidenciar a contribuição do arqueólogo aos estudos do Quaternário. Quanto às pinturas rupestres, sublinhou-se sua validade na interpretação paleoambiental a partir de representações pictóricas de animais pleistocênicos, especialmente em canhões. Utilizou-se o método etnológico-etnográfico para o reconhecimento - a partir de pinturas sobre rochas - de antigas migrações, tomando-se por base mitos, planos cosmológicos, uso de alucinógenos, etc., próprios do grupo lingüístico Tukâno. Essas conclusões foram reforçadas por registros históricos e por estudos no campo da Paleontologia Humana. Finalmente, apresentaram-se dois casos em que o homem préhistórico utilizou extensamente rochas para deixar registrado seu conhecimento astronômico e sua maneira particular de tentar uma integração com o cosmos. Nome: Claudia Guterres Vilela Título: Foraminíferos Quaternários da Plataforma Continental Norte Brasileira e do Leque do